Update on human alpha1-adrenoceptor subtype signaling and genomic organization.
Alpha1-adrenoceptors are G-protein-coupled receptors that bind catecholamines. Sixteen distinct human alpha1A-adrenoceptor isoforms have been identified from human tissues, including five full-length and 11 truncated versions. An updated scheme for the identification of alpha1A-adrenoceptor splice variants is proposed. Given the established roles of alpha1-adrenoceptors in benign prostatic hyperplasia, myocardial hypertrophy and other cardiovascular disorders, elucidation of the biological significance of the signaling diversity and potential pharmacological roles of alpha1A-adrenoceptor splice variants are important areas of future research.
Hawrylyshyn
K Ashley
KA
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Michelotti
Gregory A
GA
Cogé
Francis
F
Guénin
Sophie-Pénélope
SP
Schwinn
Debra A
DA
D000818:Animals; D002874:Chromosome Mapping; D006801:Humans; D020033:Protein Isoforms / Q000145:classification / Q000235:genetics / Q000502:physiology; D018340:Receptors, Adrenergic, alpha-1 / Q000145:classification / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction; D009626:Terminology as Topic
D020033:Protein Isoforms; D018340:Receptors, Adrenergic, alpha-1