title: An unusual pyridine nucleotide accumulating in erythrocytes: its identity and positive correlation with degree of renal failure.
abstract: We have investigated an unusual nucleotide that accumulates, with precursors, in the erythrocytes of patients in uraemia. This nucleotide is related chemically to the NAD breakdown product, N1-methyl-2-pyridone-5-carboxamide (Me2Py), found in high concentrations in the plasma of uraemic patients. Both Me2Py and the nucleotide accumulate to high concentrations in the blood during uraemia: our investigations of samples from renal out-patients have provided information on a plausible link between the two compounds.
authors.affiliation: University College London, Institute of Child Health, London, UK. e.carrey@ich.ucl.ac.uk
authors.forename: E A
authors.initials: EA
authors.lastname: Carrey
authors.forename: R T
authors.initials: RT
authors.lastname: Smolenski
authors.forename: S M
authors.initials: SM
authors.lastname: Edbury
authors.forename: A
authors.initials: A
authors.lastname: Laurence
authors.forename: A M
authors.initials: AM
authors.lastname: Marinaki
authors.forename: J A
authors.initials: JA
authors.lastname: Duley
authors.forename: L M
authors.initials: LM
authors.lastname: Zhu
authors.forename: D J A
authors.initials: DJ
authors.lastname: Goldsmith
authors.forename: H A
authors.initials: HA
authors.lastname: Simmonds
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D013058:Mass Spectrometry; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D009711:Nucleotides / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D011742:Pyrimidine Nucleotides / Q000378:metabolism; D051437:Renal Insufficiency / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D013997:Time Factors; D014466:Ultraviolet Rays; D014511:Uremia / Q000097:blood
chemical_list: D009711:Nucleotides; D011725:Pyridines; D011742:Pyrimidine Nucleotides; D009536:Niacinamide; C005211:N'-methyl-2-pyridone-5-carboxamide; C023666:pyridine