Topical treatment strategies for non-melanoma skin cancer and precursor lesions.
The ability to manage non-melanoma skin cancers and pre-malignant lesions with topical pharmacologic agents is highly compelling. This article examines currently available products and discusses their emerging roles and limitations. These include fluorouracil, diclofenac sodium, imiquimod, and photodynamic therapy.
McGillis
S Teri
ST
Department of Dermatology, Section of Dermatologic Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. mcgillt@ccf.org
Fein
Howard
H
D000287:Administration, Topical; D000634:Aminoquinolines / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D004008:Diclofenac / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077271:Imiquimod; D007642:Keratosis / Q000188:drug therapy / Q000209:etiology; D010778:Photochemotherapy; D011230:Precancerous Conditions / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D013472:Sunlight / Q000009:adverse effects
D000634:Aminoquinolines; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D004008:Diclofenac; D000077271:Imiquimod; D005472:Fluorouracil