Consequences of regulated pre-mRNA splicing in the immune system.
Alternative splicing is widely recognized to be a ubiquitous and crucial mechanism for generating protein diversity and regulating protein expression. Numerous immunologically relevant genes have been found to undergo alternative splicing; however, there has been little effort to develop a coherent picture of how alternative splicing might be used as a general mechanism to regulate the function of the immune system. In this review, I summarize the mechanisms by which splicing is controlled in T cells, and discuss the role of alternative splicing and alternative isoform expression in the regulation of T-cell activation and function.
Lynch
Kristen W
KW
Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines boulevard, Dallas, Texas 75390-9038, USA. klynch@biochem.swmed.edu
D017398:Alternative Splicing / Q000276:immunology*; D018960:Hyaluronan Receptors / Q000235:genetics; D007107:Immune System / Q000502:physiology*; D017493:Leukocyte Common Antigens / Q000235:genetics; D008213:Lymphocyte Activation / Q000235:genetics; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*
D018960:Hyaluronan Receptors; D017493:Leukocyte Common Antigens