[Penetration of microparticles into human skin].
The efficacy of the penetration of microparticles into the human skin depends on the size and the type of the formulation with which they are topically applied. Microparticles with a diameter of >1 microm barely penetrate into the human skin. They are located on the skin surface and form a film which, for instance, can be used for camouflage or protection against UV radiation in sunscreens. While the penetration of the microparticles in the lipid layers of the stratum corneum is limited, they penetrate efficiently into the hair follicles up to a depth >2 mm, providing their diameter is <1.5 microm. Thus, microparticles can be used for drug delivery into the hair follicles.
Lademann
J
J
Bereich Hautphysiologie der Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Berlin, Charité. juergen.lademann@charite.de
Schaefer
H
H
Otberg
N
N
Teichmann
A
A
Blume-Peytavi
U
U
Sterry
W
W
D004337:Drug Carriers / Q000493:pharmacokinetics*; D006801:Humans; D008863:Microspheres; D043942:Nanotubes; D010316:Particle Size; D012867:Skin / Q000378:metabolism*; D014025:Titanium / Q000493:pharmacokinetics*
D004337:Drug Carriers; D014025:Titanium