DEDB: a database of Drosophila melanogaster exons in splicing graph form.
BACKGROUND
A wealth of quality genomic and mRNA/EST sequences in recent years has provided the data required for large-scale genome-wide analysis of alternative splicing. We have capitalized on this by constructing a database that contains alternative splicing information organized as splicing graphs, where all transcripts arising from a single gene are collected, organized and classified. The splicing graph then serves as the basis for the classification of the various types of alternative splicing events.


METHODS
DEDB http://proline.bic.nus.edu.sg/dedb/index.html is a database of Drosophila melanogaster exons obtained from FlyBase arranged in a splicing graph form that permits the creation of simple rules allowing for the classification of alternative splicing events. Pfam domains were also mapped onto the protein sequences allowing users to access the impact of alternative splicing events on domain organization.


CONCLUSIONS
DEDB's catalogue of splicing graphs facilitates genome-wide classification of alternative splicing events for genome analysis. The splicing graph viewer brings together genome, transcript, protein and domain information to facilitate biologists in understanding the implications of alternative splicing.
Lee
Bernett T K
BT
Department of Biochemistry, National University of Singapore, Singapore. bernett@bic.nus.edu.sg <bernett@bic.nus.edu.sg>
Tan
Tin Wee
TW
Ranganathan
Shoba
S
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D002965:Classification / Q000379:methods; D003196:Computer Graphics; D030541:Databases, Genetic; D004331:Drosophila melanogaster / Q000235:genetics*; D005091:Exons / Q000235:genetics*; D005544:Forecasting; D016678:Genome