Topical PDGF-BB results in limited healing in a patient with Werner's syndrome and chronic leg ulcers.
Impaired wound healing is a feature of Werner's syndrome. Treatment of one such patient with painful chronic leg ulcers included topical application of PDGF-BB. Granulation increased slightly, enabling full-thickness skin grafting to take place.
Wollina
U
U
Department of Dermatology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany. wollina-uw@khdf.de
Gruner
M
M
Koch
A
A
Köstler
E
E
Hubl
W
W
Hanson
N B
NB
Oshima
J
J
D000279:Administration, Cutaneous; D000077214:Becaplermin; D003094:Collagen / Q000235:genetics; D017364:Collagenases / Q000235:genetics; D006801:Humans; D007871:Leg Ulcer / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology / Q000627:therapeutic use*; D020574:Proto-Oncogene Proteins c-sis; D017592:Skin Care / Q000379:methods; D016896:Treatment Outcome; D014898:Werner Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D014945:Wound Healing / Q000187:drug effects
D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin; D003094:Collagen; D017364:Collagenases