IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains.
IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates. The NUMEROTATION concept of IMGT-ONTOLOGY has allowed to define a unique numbering for the variable domains (V-DOMAINs) and for the V-LIKE-DOMAINs. In this paper, this standardized characterization is extended to the constant domains (C-DOMAINs), and to the C-LIKE-DOMAINs, leading, for the first time, to their standardized description of mutations, allelic polymorphisms, two-dimensional (2D) representations and tridimensional (3D) structures. The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains, V-DOMAINs and C-DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMAINs and C-LIKE-DOMAINs of proteins other than IG and TR, in any species.
Lefranc
Marie-Paule
MP
IMGT, the International ImMunoGeneTics Information System, LIGM, Laboratoire d'ImmunoGénétique Moléculaire, Université Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier cedex 5, France. lefranc@ligm.igh.cnrs.fr
Pommié
Christelle
C
Kaas
Quentin
Q
Duprat
Elodie
E
Bosc
Nathalie
N
Guiraudou
Delphine
D
Jean
Christelle
C
Ruiz
Manuel
M
Da Piédade
Isabelle
I
Rouard
Mathieu
M
Foulquier
Elodie
E
Thouvenin
Valérie
V
Lefranc
Gérard
G
D000595:Amino Acid Sequence; D006801:Humans; D007136:Immunoglobulins; D020407:Internet; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011948:Receptors, Antigen, T-Cell; D017422:Sequence Analysis, DNA; D020539:Sequence Analysis, Protein; D009626:Terminology as Topic
D007136:Immunoglobulins; D011948:Receptors, Antigen, T-Cell