Effects of hormone replacement therapy or raloxifene on ambulatory blood pressure and arterial stiffness in treated hypertensive postmenopausal women.
The administration of oral raloxifene in 30 postmenopausal hypertensive women was evaluated to demonstrate its effect on arterial stiffness. Casual and ambulatory blood pressure (BP) and pulse-wave velocity (PWV) data were obtained before and after patients received raloxifene, estrogen-progestin replacement therapy, or placebo in a randomized crossover study. It was shown that the 2 therapies decreased BP and carotid-femoral PWV, and the effect of raloxifene on vascular compliance was independent of the effects on BP.
da Costa
Lílian Soares
LS
General Hospital, Santa Casa Misericórdia of Rio de Janeiro, Rio de Janeiro, Brazil.
de Oliveira
Monica Amorim
MA
Rubim
Valéria Siqueira Martins
VS
Wajngarten
Maurício
M
Aldrighi
José Mendes
JM
Rosano
Giuseppe M
GM
Neto
Cantidio Drumond
CD
Gebara
Otavio Celso Eluf
OC
D000284:Administration, Oral; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D018592:Cross-Over Studies; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017698:Postmenopause; D020849:Raloxifene Hydrochloride / Q000494:pharmacology* / Q000627:therapeutic use*; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology* / Q000627:therapeutic use*; D014655:Vascular Resistance
D020845:Selective Estrogen Receptor Modulators; D020849:Raloxifene Hydrochloride