Nacre/bone interface changes in durable nacre endosseous implants in sheep.
Raw nacre implants persist even after 9 months of implantation into bone tissue in sheep. However the nacre surface undergoes a limited biodegradation process. Smooth-surfaced nacre implants were seen to become microporous after implantation. The results of these long-term, in vivo studies show that the overall process involves bone-resorbing cells, relies on a two-phase mechanism and may correspond to a regulation process. The rate of surface change depends on the bone implantation site and the nacre/bone interaction. The in vivo biodegradability of nacre is a highly variable parameter. The size and shape of the implanted nacre and the cellular environment of the implant are key factors in determining the biodegradation kinetics of the nacre in a living system.
Berland
S
S
Museum National d'Histoire Naturelle, Département des Milieux et Peuplements Aquatiques, 7, rue Cuvier, USM 401, UMR CNRS 5178, 75231 Paris cedex 05, France. berland@mnhn.fr
Delattre
O
O
Borzeix
S
S
Catonné
Y
Y
Lopez
E
E
D000818:Animals; D001672:Biocompatible Materials; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods* / Q000473:pathology* / Q000502:physiology; D005260:Female; D005269:Femur / Q000473:pathology* / Q000601:surgery*; D020007:Implants, Experimental; D008422:Materials Testing; D008974:Mollusca / Q000502:physiology* / Q000648:ultrastructure; D016348:Osseointegration / Q000502:physiology; D012756:Sheep
D001672:Biocompatible Materials; D018786:Bone Substitutes