Molecular aspects of vascular tissue engineering.
Cardiovascular disease remains the number one cause of death in the United States. Most current surgical procedures to alleviate this disease rely on the availability of suitable small diameter vascular grafts, which are constrained by several limitations. Tissue engineering brings new hope to this field, but still faces many challenges. This review focuses on the molecular aspects of the different components of vascular tissue engineering. The topics addressed include the cell type, extracellular matrix, and physical and biochemical stimulation with respect to their role in the development of a tissue engineered vascular graft.
Vorp
David A
DA
University of Pittsburgh, Department of Surgery, McGowan Institute for Regenerative Medicine, 100 Technology Drive, Pittsburgh, PA 15219, USA. vorpda@upmc.edu <vorpda@upmc.edu>
Maul
Timothy
T
Nieponice
Alejandro
A
D000818:Animals; D001671:Biochemistry / Q000379:methods; D004730:Endothelium, Vascular / Q000473:pathology*; D005347:Fibroblasts / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D009130:Muscle, Smooth / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000379:methods*
D006133:Growth Substances