title: Superior long-term results of simultaneous pancreas-kidney transplantation from pediatric donors.
abstract: The shortage of cadaveric donors for simultaneous pancreas-kidney transplantation has prompted the use of cadaveric organs from pediatric donors. The long-term outcome and its impact on overall long-term survival are unknown. A total of 680 recipients receiving cadaver Simultaneous pancreas-kidney (SPK) transplantation from pediatric and adult donors between July 1986 and September 2001 were analyzed and compared. Ten-year kidney and pancreas graft survival for SPK transplantation from donors aged <18 years (n = 142) were 80% and 72%, respectively, compared to 61% pancreas and kidney graft survival from donors > or =18 years of age (n = 538; p = 0.03 and 0.05, respectively). Five years post-transplant, blood glucose, HbA1c and creatinine clearance were significantly better in recipients from pediatric donors (85.3 +/- 13 mg/dL, 5.5 +/- 3.5% and 65.6 +/- 16 mL/min, respectively), compared to recipients from adult donors (95.1 +/- 29 mg/dL, 5.9 +/- 3.5% and 58.3 +/- 17 mL/min; p = 0.001, 0.01 and 0.002, respectively). Causes of graft failure for kidney and pancreas transplants were similar between the two groups. No statistically significant difference was observed in patient survival between recipients from pediatric donors compared to adult donors (85% vs. 76%, p = 0.29). When recipients of SPK from pediatric donors were stratified according to age (3-11 years and 12-17 years) and compared, no difference in kidney or pancreas graft survival was observed (kidney 76.4% vs. 81.3%, p = 0.15; pancreas 75% vs. 76%, p = 0.10, respectively). Pediatric donors represent a valuable source of organs, providing excellent short- and long-term outcomes. Wide utilization of pediatric organs will substantially increase the donor pool.
authors.affiliation: Division of Transplantation, Department of Medicine, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792-7375, USA. luisf@surgery.wisc.edu
authors.forename: Luis A
authors.initials: LA
authors.lastname: Fernandez
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Turgeon
authors.forename: Jon S
authors.initials: JS
authors.lastname: Odorico
authors.forename: Glen
authors.initials: G
authors.lastname: Leverson
authors.forename: John D
authors.initials: JD
authors.lastname: Pirsch
authors.forename: Bryan N
authors.initials: BN
authors.lastname: Becker
authors.forename: L Thomas
authors.initials: LT
authors.lastname: Chin
authors.forename: Yolanda T
authors.initials: YT
authors.lastname: Becker
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Knechtle
authors.forename: David P
authors.initials: DP
authors.lastname: Foley
authors.forename: Brian D
authors.initials: BD
authors.lastname: Shames
authors.forename: Munci
authors.initials: M
authors.lastname: Kalayoglu
authors.forename: Anthony M
authors.initials: AM
authors.lastname: D'Alessandro
authors.forename: Hans W
authors.initials: HW
authors.lastname: Sollinger
mesh_terms: D000293:Adolescent; D000328:Adult; D002102:Cadaver; D002648:Child; D005260:Female; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology*; D008297:Male; D016035:Pancreas Transplantation / Q000502:physiology*; D016019:Survival Analysis; D013997:Time Factors; D014019:Tissue Donors / Q000706:statistics & numerical data* / Q000600:supply & distribution; D016896:Treatment Outcome