title: Gut transit in celiac disease: delay of small bowel transit and acceleration after dietary treatment.
abstract: OBJECTIVE
  New studies indicate that body mass index (BMI) may influence gut transit. We studied gut transit and BMI in patients with celiac disease before and after treatment.
  
  
  METHODS
  Twenty-seven (16 female) patients with untreated celiac disease were included for detailed gastrointestinal transit measurement and calculation of BMI. Ten patients (5 female) were also studied after dietary treatment. A newly developed radiological transit procedure was used. Eighty-three healthy subjects were used as controls.
  
  
  RESULTS
  In untreated male patients BMI was significantly reduced compared to healthy males, and small bowel transit time (SBTT) was significantly longer compared with healthy males, 3.9 (1.2-5.5) versus 2.5 h (1.4-4.3), median and percentile 10 and 90, respectively, and p= 0.04. In the 10 men and women with repeated measurements, BMI increased significantly and small bowel transit accelerated after treatment and was 3.6 h (1.7-5.5) before treatment and 2.3 h (0.7-4.0) after treatment, and p= 0.007. In women, BMI did not differ significantly between untreated patients and healthy subjects, and 31% of the female patients were overweight. Small bowel transit was significantly faster in untreated female patients who were overweight compared with lean female patients.
  
  
  CONCLUSIONS
  Small bowel transit seems to be delayed in lean patients with untreated celiac disease. BMI may have some influence on the variations of small bowel transit before and after treatment.
authors.affiliation: Section of Gastroenterology, Institute of Internal Medicine, Sahlgrenska University Hospital, University of Göteborg, 413045 Göteborg, Sweden.
authors.forename: Riadh
authors.initials: R
authors.lastname: Sadik
authors.forename: Hasse
authors.initials: H
authors.lastname: Abrahamsson
authors.forename: Anders
authors.initials: A
authors.lastname: Kilander
authors.forename: Per-Ove
authors.initials: PO
authors.lastname: Stotzer
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D002446:Celiac Disease / Q000178:diet therapy / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D018709:Statistics, Nonparametric