title: [Differences in cerebral glucose metabolism between frontotemporal lobar degeneration and Alzheimer's disease].
abstract: OBJECTIVE
  To describe differences in cerebral glucose metabolism between frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD).
  
  
  METHODS
  14 patients with FTLD (7 f/7 m, mean age 60.1 years) and 14 patients with AD (7 f/7 m, mean age 59.5 years) were examined. [18F]FDG positron emission tomography (PET) scans were analysed with statistical nonparametric mapping (SnPM) and statistical parametric mapping (SPM99).
  
  
  RESULTS
  Significant decreases in glucose metabolism in FTLD compared to AD were detected in the left insula/left inferior frontal gyrus (Brodman area [BA]13, 45 and 47) and in the medial frontal gyrus bilaterally (BA10). A significant decrease in AD compared to FTLD was identified in the right middle temporal gyrus (BA39).
  
  
  CONCLUSIONS
  Cerebral PET could be a promising tool to discriminate FTLD from AD.
authors.affiliation: Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg am Bezirksklinikum. stefan.poljansky@medbo.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Poljansky
authors.forename: Bernd
authors.initials: B
authors.lastname: Ibach
authors.forename: Matthias
authors.initials: M
authors.lastname: Vogel
authors.forename: Peter
authors.initials: P
authors.lastname: Männer
authors.forename: Jörg
authors.initials: J
authors.lastname: Marienhagen
authors.forename: Göran
authors.initials: G
authors.lastname: Hajak
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001786:Blood Glucose / Q000378:metabolism*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D003704:Dementia / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18