Expression of bmp2a and bmp2b in late-stage zebrafish median fin development.
Zebrafish bmp2a and bmp2b mRNA expression in the developing median fins (caudal, anal, and dorsal) of late-stage larvae (>5 days post-fertilization) was analyzed by reverse transcriptase-PCR (RT-PCR) and in situ hybridization. bmp2a is expressed in developing fin rays, while bmp2b is expressed in developing fin rays, hypertrophic chondrocytes, and in the zone of segmentation (ZS) in developing anal and dorsal fin radials. This latter pattern of bmp2b expression in the ZS mirrors tetrapod bmp2 expression in developing joints. Additionally, both genes are expressed in neural and hemal arches and spines. bmp2a is strongly expressed in the lens; lens bmp2b expression is detected only weakly via RT-PCR.
Crotwell
Patricia L
PL
Department of Biology, University of South Dakota, 414 East Clark Street, CL-191, Vermillion, SD 57069, USA.
Sommervold
Amber R
AR
Mabee
Paula M
PM
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D019902:Chondrocytes / Q000378:metabolism; D005121:Extremities / Q000254:growth & development; D018507:Gene Expression Regulation, Developmental; D007814:Larva / Q000254:growth & development / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D015027:Zebrafish / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000096:biosynthesis* / Q000378:metabolism
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D012333:RNA, Messenger; D029961:Zebrafish Proteins; C405936:bmp2b protein, zebrafish