title: [Clinical analyses of Aspergillus infections in patients with underlying pulmonary disease].
abstract: To elucidate the clinical features of Aspergillus infections with underlying pulmonary disease, we analyzed 79 cases with positive results for anti-aspergillus antibody. The patients were 69 men and 10 women. Mean age at diagnosis was 68.0. Positive rates for isolation of Aspergillus spp. from the airways, and of galactomannan antigen and 1, 3-beta-D glucan in the serum were 44.3, 21.8, 26.5%, respectively. These findings did not show any differences according to underlying pulmonary disease. Twenty-nine patients died of the disease. Body mass indices, serum albumin levels and red blood cell counts were significantly lower in the patients who died. Extension of the lesion to the lower lobes or to 3 or more lobes was correlated significantly with poor survival. A specific diagnostic tool was required for early detection of the disease.
authors.affiliation: Department of Clinical Research, Dohoku National Hospital, National Hospital Organization.
authors.forename: Satoru
authors.initials: S
authors.lastname: Fujiuchi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Akinori
authors.initials: A
authors.lastname: Takeda
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nishigaki
authors.forename: Yuka
authors.initials: Y
authors.lastname: Fujita
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Fujikane
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000368:Aged; D000908:Antibodies, Fungal / Q000097:blood*; D001228:Aspergillosis / Q000209:etiology* / Q000401:mortality; D001230:Aspergillus / Q000276:immunology*; D003560:Cysts / Q000150:complications; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications; D008172:Lung Diseases, Fungal / Q000209:etiology* / Q000401:mortality; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000150:complications*; D015996:Survival Rate; D014397:Tuberculosis, Pulmonary / Q000150:complications*
chemical_list: D000908:Antibodies, Fungal