Successful treatment of pure red cell aplasia associated with systemic lupus erythematosus with oral danazol and steroid.
We describe a middle-aged Chinese systemic lupus erythematosus (SLE) patient developing steroid refractory and transfusion dependent red cell aplasia. Oral danazol 200 mg twice per day was started together with low-dose prednisolone therapy. There was no further recurrence of anemia 1 month after this combined therapy.
Chan
Alice Y K
AY
Rheumatology Unit, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. alice_ykchan@yahoo.com
Li
Edmund K
EK
Tam
L S
LS
Cheng
Gregory
G
Choi
Paul C L
PC
D000284:Administration, Oral; D003613:Danazol / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*; D012010:Red-Cell Aplasia, Pure / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
D004965:Estrogen Antagonists; D005938:Glucocorticoids; D011239:Prednisolone; D003613:Danazol