title: [Significance of Toll-like receptors in the pathophysiology of surgical sepsis].
abstract: The discovery of Toll-like receptors has substantially changed our knowledge of pathogen recognition. 11 Toll-like receptors have so far been described in humans. These recognize distinct pathogen associated molecular patterns, as well as endogenous ligands and small molecular synthetic compounds. TLRs have a multifunctional role in pathogen-triggered immune responses and represent an important connection between the "innate" and "adaptive" immunity. The role of the TLRs in the recognition of pathogens renders them a key figure in the activation of the immune response during surgical sepsis. However, emerging evidence points to a fundamental role in tumorigenesis, transplantation, wound healing, atherogenesis and inflammatory bowel disease. The aim hence was to review experimental data pertaining to the activation of TLR signalling pathways in conditions associated with surgical sepsis. A systematic review of the literature was undertaken by searching the MEDLINE database for the period 1966-2004 without language restriction. The paper also analyses the possible therapeutic utilization of the TLR signalling pathways in surgical sepsis.
authors.affiliation: Department of Surgery, Cork University Hospital, National University of Ireland, Cork, Ireland. Laszlo.Romics@umassmed.edu
authors.forename: László
authors.initials: L
authors.lastname: Romics
authors.forename: John Calvin
authors.initials: JC
authors.lastname: Coffey
authors.forename: Jiang Huai
authors.initials: JH
authors.lastname: Wang
authors.forename: Henry Paul
authors.initials: HP
authors.lastname: Redmond
authors.forename: Gyöngyi
authors.initials: G
authors.lastname: Szabó
mesh_terms: D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018805:Sepsis / Q000209:etiology / Q000378:metabolism*; D015398:Signal Transduction; D013530:Surgical Wound Infection / Q000378:metabolism*; D051193:Toll-Like Receptors
chemical_list: D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors