title: Effect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR rats.
abstract: We studied the effects of spontaneous high blood pressure and the captopril treatment on the subfornical organ (SFO) of rats. The brains of control Wistar-Kyoto rats (WKY), WKY rats treated with captopril (WKY-T), spontaneously hypertensive rats (SHR) and SHR rats treated with captopril (SHR-T) were processed immunohistochemically using anti-angiotensin II as primary antibody. Immunorective material (IRM) for angiotensin II was observed in a group of neurons and some cells of the ependymal layer of the SFO in WKY rats. The angiotensin II immunoreactive (AGII-ir) in the SHR rats was decreased, showing positive reaction only in a few neurons, while captopril treatment induced an increase in immunoreactive material in hypertensive rats, but contrarily, the expression of AGII-ir in the WKY-T group was scarce. The variations of the angiotensin II observed in the SFO could be owing to an interaction between the hypertension and its captopril treatment.
authors.affiliation: Departamento de Anatomía, Facultad de Medicina, Universidad de La Laguna, Tenerife, Spain. ecarmona@ull.es
authors.forename: E M
authors.initials: EM
authors.lastname: Carmona-Calero
authors.forename: H
authors.initials: H
authors.lastname: Perez-Gonzalez
authors.forename: I
authors.initials: I
authors.lastname: Martinez-Peña Y Valenzuela
authors.forename: I
authors.initials: I
authors.lastname: Gonzalez-Marrero
authors.forename: C G
authors.initials: CG
authors.lastname: Perez-Garcia
authors.forename: N
authors.initials: N
authors.lastname: Marrero-Gordillo
authors.forename: C
authors.initials: C
authors.lastname: Ormazabal-Ramos
authors.forename: A
authors.initials: A
authors.lastname: Castañeyra-Perdomo
authors.forename: R
authors.initials: R
authors.lastname: Ferres-Torres
mesh_terms: D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002216:Captopril / Q000494:pharmacology*; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D013356:Subfornical Organ / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D000804:Angiotensin II; D002216:Captopril