title: Synthesis and antifungal activity of cholesterol-hydrazone derivatives.
abstract: A series of hydrazones synthesized from various cholesterol derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. The activity was highly dependent on the structure of the different compounds involved. The best results have been obtained with tosylhydrazone cholesterol derivatives 8 and 9 exhibiting activities against Candida albicans (CIP 1663-80) at a concentration of 1.5 microg/ml.
authors.affiliation: Laboratoire synthèse et étude de substances naturelles à activités biologiques (SESNAB), IMRN INRA 1111, faculté des sciences et techniques de St Jérôme, université Paul Cézanne, Aix-Marseille III, 13397 Marseille 20, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Loncle
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Brunel
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vidal
authors.forename: Michel
authors.initials: M
authors.lastname: Dherbomez
authors.forename: Yves
authors.initials: Y
authors.lastname: Letourneux
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006835:Hydrazones; D002784:Cholesterol