Adenylosuccinate lyase deficiency: study of physiopathologic mechanism(s).
Nucleotide concentrations were normal in adenylosuccinate lyase-deficient fibroblasts, and the succinylpurines were not toxic for cultured neuronal cells.
Race
V
V
Laboratory of Physiological Chemistry, C de Duve Institute of Cellular Pathology, Brussels, Belgium.
Marie
S
S
Kienlen-Campard
P
P
Hermans
E
E
Octave
J N
JN
Van den Berghe
G
G
Vincent
M F
MF
D000264:Adenylosuccinate Lyase / Q000172:deficiency* / Q000235:genetics*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D005347:Fibroblasts / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000378:metabolism; D011686:Purine-Pyrimidine Metabolism, Inborn Errors / Q000175:diagnosis / Q000235:genetics; D011687:Purines / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000378:metabolism; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D013997:Time Factors
D011687:Purines; D013778:Tetrazolium Salts; D013844:Thiazoles; D000264:Adenylosuccinate Lyase; C022616:thiazolyl blue; D002118:Calcium