GUD1 (YDL238c) encodes Saccharomyces cerevisiae guanine deaminase, an enzyme expressed during post-diauxic growth.
Purine salvage is a complex pathway allowing a correct balance between adenylic and guanylic derivatives. In this paper, we show that GUD1 (YDL238c) encodes guanine deaminase, a catabolic enzyme producing xanthine and ammonia from guanine. Importantly, Gud1p activity was higher during post-diauxic growth, suggesting that a decrease of the guanylic nucleotide pool could be required when cells shift from proliferation to quiescence.
Saint-Marc
Christelle
C
Institut de Biochimie et Génétique Cellulaires, Université Bordeaux 2 CNRS UMR 5095, 33077 Bordeaux Cedex, France.
Daignan-Fornier
Bertrand
B
D000595:Amino Acid Sequence; D005800:Genes, Fungal; D006148:Guanine Deaminase / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development; D029701:Saccharomyces cerevisiae Proteins / Q000096:biosynthesis / Q000235:genetics*; D016415:Sequence Alignment
D029701:Saccharomyces cerevisiae Proteins; C496279:GUD1 protein, S cerevisiae; D006148:Guanine Deaminase