title: Use of imidacloprid-permethrin to prevent transmission of Anaplasma phagocytophilum from naturally infected Ixodes scapularis ticks to dogs.
abstract: One group of eight beagles was treated with a combination of imidacloprid and permethrin 7 days before exposure to Ixodes scapularis ticks that were naturally infected with Anaplasma phagocytophilum. A second group of eight beagles was not treated and was also exposed to infected ticks. Seven of eight non-treated dogs--but none of the treated dogs--developed specific antibodies to A. phagocytophilum. Results of this study indicate that a combination of imidacloprid and permethrin can prevent transmission of A. phagocytophilum to dogs if administered before exposure to infected ticks.
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849, USA.
authors.forename: Byron L
authors.initials: BL
authors.lastname: Blagburn
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Spencer
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Billeter
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Drazenovich
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Butler
authors.forename: Tracey M
authors.initials: TM
authors.lastname: Land
authors.forename: Christine C
authors.initials: CC
authors.lastname: Dykstra
authors.forename: Kirby C
authors.initials: KC
authors.lastname: Stafford
authors.forename: Margaret B
authors.initials: MB
authors.lastname: Pough
authors.forename: Steven A
authors.initials: SA
authors.lastname: Levy
authors.forename: David L
authors.initials: DL
authors.lastname: Bledsoe
mesh_terms: D041081:Anaplasma phagocytophilum; D000818:Animals; D001096:Arachnid Vectors / Q000382:microbiology*; D004283:Dog Diseases / Q000517:prevention & control* / Q000635:transmission; D004285:Dogs; D016873:Ehrlichiosis / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D005260:Female; D007093:Imidazoles / Q000627:therapeutic use; D007306:Insecticides / Q000627:therapeutic use*; D018884:Ixodes / Q000382:microbiology*; D008297:Male; D000073943:Neonicotinoids; D009574:Nitro Compounds; D026023:Permethrin / Q000627:therapeutic use; D011897:Random Allocation; D013984:Tick Infestations / Q000517:prevention & control / Q000662:veterinary*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007093:Imidazoles; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; C082359:imidacloprid; D026023:Permethrin