Extracellular circulating nucleic acids in human plasma in health and disease.
The concentration of extracellular DNA and RNA in blood plasma of healthy donors, trauma patients, patients with breast and lung cancer, nonmalignant breast tumors and nonmalignant lung diseases were estimated. Significant amounts of extracellular RNA were found in plasma of trauma patients. The concentration of DNA and RNA in plasma of trauma patients correlates with the extent of posttraumatic organ failure. Extracellular RNA was not found in the plasma of breast cancer patients and patients with nonmalignant breast tumors, whereas a very high concentration of extracellular RNA was found in patients with malignant and nonmalignant diseases of lung.
Laktionov
Pavel P
PP
Institute of Bioorganic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. lakt@niboch.nsc.ru
Tamkovich
Svetlana N
SN
Rykova
Elena Yu
EY
Bryzgunova
Olga E
OE
Starikov
Andrey V
AV
Kuznetsova
Nina P
NP
Sumarokov
Sergey V
SV
Kolomiets
Sergey A
SA
Sevostianova
Natalya V
NV
Vlassov
Valentin V
VV
D001943:Breast Neoplasms / Q000097:blood*; D016022:Case-Control Studies; D004247:DNA / Q000097:blood*; D006801:Humans; D008171:Lung Diseases / Q000097:blood*; D012313:RNA / Q000097:blood*; D014947:Wounds and Injuries / Q000097:blood*
D012313:RNA; D004247:DNA