title: Epidemiology, pathogenesis and prevention of congenital cytomegalovirus infection.
abstract: Cytomegalovirus is the most common cause of congenital infection. Congenital cytomegalovirus infection can follow both primary and recurrent maternal infections. It is associated with a significant burden of disease and death. The determinants of mother-to-child transmission and the pathogenesis of symptomatic fetal infection remain poorly understood. For a long time, congenital cytomegalovirus infection has been a neglected disease. Recently, the Institute of Medicine has recognized that the development of a vaccine against congenital cytomegalovirus infection is a public health priority, which should stimulate research in this area. The development of antiviral therapies to prevent symptoms in infected newborns also represents an important area of research.
authors.affiliation: Laboratory of Experimental Immunology, Université Libre de Bruxelles, Belgium. wburny@ulb.ac.be
authors.forename: Wivine
authors.initials: W
authors.lastname: Burny
authors.forename: Corinne
authors.initials: C
authors.lastname: Liesnard
authors.forename: Catherine
authors.initials: C
authors.lastname: Donner
authors.forename: Arnaud
authors.initials: A
authors.lastname: Marchant
mesh_terms: D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D022482:Cytomegalovirus Vaccines / Q000008:administration & dosage / Q000276:immunology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D022482:Cytomegalovirus Vaccines