Pore formation in and enlargement of phospholipid liposomes by synthetic models of ceramides and sphingomyelin.
A family of compounds having twin octadecyl anchor chains and various polar headgroups were designed to be ceramide mimics. The compounds prepared increase the apparent permeability of phospholipid vesicles to chloride and carboxyfluorescein anions. In addition, significantly larger vesicles are observed after exposure to these compounds suggesting the possibility of vesicular fusion.
Pajewski
Robert
R
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
Djedovic
Natasha
N
Harder
Egan
E
Ferdani
Riccardo
R
Schlesinger
Paul H
PH
Gokel
George W
GW
D002518:Ceramides / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry; D005452:Fluoresceins / Q000737:chemistry; D008081:Liposomes; D010743:Phospholipids / Q000737:chemistry*; D013109:Sphingomyelins / Q000737:chemistry*
D002518:Ceramides; D002712:Chlorides; D005452:Fluoresceins; D008081:Liposomes; D010743:Phospholipids; D013109:Sphingomyelins; C024098:6-carboxyfluorescein