(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga.
A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 mug/mL and against Candida glabrata with a MIC of 30 microg/mL.
Kossuga
Miriam H
MH
Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil.
MacMillan
John B
JB
Rogers
Evan W
EW
Molinski
Tadeusz F
TF
Nascimento
Gislene G F
GG
Rocha
Rosana M
RM
Berlinck
Roberto G S
RG
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D002175:Candida / Q000187:drug effects*; D002942:Circular Dichroism; D007851:Dodecanol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D013237:Stereoisomerism; D014561:Urochordata / Q000737:chemistry*
C495165:2-aminododecan-3-ol; D000935:Antifungal Agents; D007851:Dodecanol