title: Dynamics of accommodative fatigue in rhesus monkeys and humans.
abstract: Changes in accommodative dynamics with repeated accommodation were studied in three anesthetized rhesus monkeys and two conscious humans. Maximum accommodation was centrally stimulated via the Edinger-Westphal nucleus in monkeys with a 4 s on, 4 s off paradigm (4 x 4) for 17 min, 4 x 1.5 for 27 min and 2 x 1 for 16 min. Humans accommodated repeatedly to visual targets (5 x 5; 5D and 2 x 2; 6D) for 30 min. In all cases, accommodation was sustained throughout. The anesthetized monkeys showed inter-individual variability in the extent of changes in accommodative dynamics over time while no systematic changes were detected in the human accommodative responses. Little accommodative fatigue was found compared to previous studies which have reported a complete loss of accommodation after 5 min of repeated stimulation in monkeys.
authors.affiliation: College of Optometry, University of Houston, 505 J Davis Armistead Bldg, 4901 Calhoun Rd, Houston, TX 77004, USA.
authors.forename: Abhiram S
authors.initials: AS
authors.lastname: Vilupuru
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Kasthurirangan
authors.forename: Adrian
authors.initials: A
authors.lastname: Glasser
mesh_terms: D000065:Accommodation, Ocular / Q000502:physiology*; D000328:Adult; D000818:Animals; D002924:Ciliary Body / Q000502:physiology; D004558:Electric Stimulation / Q000379:methods; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology; D008253:Macaca mulatta; D018763:Muscle Fatigue / Q000502:physiology*; D013045:Species Specificity; D013997:Time Factors