Ortho alkylation of aromatic ketimine with functionalized alkene by Rh(I) catalyst.
[reaction: see text] The reaction of the imine of aromatic ketones with functionalized alkenes was performed under a catalytic amount of (PPh3)3RhCl, and corresponding ortho-alkylated ketones were obtained after hydrolysis. A variety of functional groups in the alkene were tolerated in this ortho alkylation. This procedure expands the scope of ortho alkylation to the direct ortho functionalization of aromatic ketones.
Lim
Sung-Gon
SG
Center for Bioactive Molecular Hybrid (CBMH), Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
Ahn
Jeong-Ae
JA
Jun
Chul-Ho
CH