CSF characteristics in early-onset multiple sclerosis.
The authors studied CSF characteristics in 136 patients with multiple sclerosis (MS) with a disease onset before age 16. In the initial diagnostic lumbar puncture, CSF-pleocytosis was observed in 66%, blood-CSF barrier dysfunction in 13%, and oligoclonal IgG in 92% of the early-onset MS (EOMS) patients. CSF oligoclonal IgG supports the early diagnosis of MS in childhood with a sensitivity similar to adult-onset MS.
Pohl
D
D
Department of Pediatrics and Pediatric Neurology, Georg-August-University Goettingen, Robert-Koch-Strasse 40, 37075 Goettingen, Germany. dpohl@med.uni-goettingen.de
Rostasy
K
K
Reiber
H
H
Hanefeld
F
F
D000293:Adolescent; D017668:Age of Onset; D000418:Albumins / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003937:Diagnosis, Differential; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D007964:Leukocytosis / Q000209:etiology; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000453:epidemiology; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid; D011446:Prospective Studies; D012709:Serum Albumin / Q000032:analysis; D013129:Spinal Puncture
D000418:Albumins; D002556:Cerebrospinal Fluid Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D043025:Oligoclonal Bands; D012709:Serum Albumin