title: [Antitumor effect of natural avermectins].
abstract: The effects of the natural avermectin complex, aversectin C and individual avermectin B1 on the growth of ascitic and solid transplantable tumors in animals were studied. The results showed for the first time that both aversectin C and avermectin B1 possessed marked antitumor activity. In subtoxic doses aversectin C significantly inhibited the growth of P388 lymphoid leukemia and Ehrlich carcinoma, both ascitic and solid ones. In some administration regimens aversectin C inhibited the tumor growth by 70 to 80%. The highest effect of aversectin C was observed after its intraperitoneal administration. Avermectin B1 inhibited the growth of solid Ehrlich carcinoma and carcinoma 755.
authors.forename: V A
authors.initials: VA
authors.lastname: Driniaev
authors.forename: V A
authors.initials: VA
authors.lastname: Mosin
authors.forename: E B
authors.initials: EB
authors.lastname: Krugliak
authors.forename: T S
authors.initials: TS
authors.lastname: Sterlina
authors.forename: T S
authors.initials: TS
authors.lastname: Novik
authors.forename: N V
authors.initials: NV
authors.lastname: Ermakova
authors.forename: L N
authors.initials: LN
authors.lastname: Kublik
authors.forename: M Kh
authors.initials: MKh
authors.lastname: Levitman
authors.forename: V V
authors.initials: VV
authors.lastname: Shaposhnikova
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Korystov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice
chemical_list: D000970:Antineoplastic Agents; C048324:abamectin; D007559:Ivermectin; C019264:avermectin