title: Improvement of insulin resistance and insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized rats.
abstract: The effect of supplementation with Phellinus linteus (P. linteus), Paecilomyces tenuipes (P. tenuipes), and Cordyceps militaris (C. militaris) mushroom water extracts on the insulin secretion and insulin resistance of 90% pancreatectomized (Px) male Sprague Dawley rats was investigated. Px rats were daily administered 0.5 g of P. linteus, P. tenuipes, and C. militaris aqueous extracts or a placebo per 1 kg body weight with a 40% fat diet for 8 weeks. Fasting serum glucose levels were lower in rats receiving C. militaris than in the control group. Insulin secretion at the elevated serum glucose levels was lowest in rats that consumed P. tenuipes in hyperglycemic clamp. Whole body glucose disposal rates increased in C. militaris but decreased in P. tenuipes compared to those in the control group in euglycemic hyperinsulinemic clamp. The GLUT4 content and fraction velocity of glycogen synthase in the soleus and quadriceps muscles increased in the rats treated with C. militaris, but P. tenuipes decreased both. In sum, a water extract of C. militaris ameliorates insulin resistance by enhancing glucose utilization in skeletal muscles.
authors.affiliation: Internal Medicine, KonKuk University, ChungBuk-Do, Korea.
authors.forename: Soo Bong
authors.initials: SB
authors.lastname: Choi
authors.forename: Chun Hee
authors.initials: CH
authors.lastname: Park
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Choi
authors.forename: Dong Wha
authors.initials: DW
authors.lastname: Jun
authors.forename: Sunmin
authors.initials: S
authors.lastname: Park
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D032661:Cordyceps / Q000737:chemistry*; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology; D004326:Drinking; D004435:Eating; D015309:Glucose Clamp Technique; D006006:Glycogen Synthase / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D000078790:Insulin Secretion; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D010143:Paecilomyces / Q000737:chemistry*; D010180:Pancreatectomy; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D010936:Plant Extracts; D006006:Glycogen Synthase