Glucocorticoids increase in vitro and in vivo activities of antibiotics against Chlamydophila pneumoniae.
The in vitro and in vivo antichlamydial activities of dexamethasone and beclomethasone alone and in combination with an antibiotic were tested. In vitro, dexamethasone and beclomethasone decreased the number of inclusion-forming units versus the control number (P < 0.001). The combination of glucocorticoids with azithromycin, telithromycin, or levofloxacin was more active than antibiotics used alone (P < 0.001). The combination, tested in a murine Chlamydophila pneumoniae infection model, produced similar results.
Caronzolo
Dario
D
Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Milan, Italy.
Lucini
Valeria
V
Pannacci
Marilou
M
Grosso
Silvia
S
Colleoni
Federica
F
Fraschini
Franco
F
Scaglione
Francesco
F
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D017963:Azithromycin / Q000494:pharmacology / Q000627:therapeutic use; D002460:Cell Line; D023521:Chlamydophila Infections / Q000188:drug therapy* / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use; D004357:Drug Synergism; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D048628:Ketolides / Q000494:pharmacology / Q000627:therapeutic use; D064704:Levofloxacin; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D048628:Ketolides; D064704:Levofloxacin; D003907:Dexamethasone; D017963:Azithromycin; D015242:Ofloxacin; C106791:telithromycin