Significance of enzyme degradation rate and enzyme inhibition in targeted chemotherapy.
Weber
George
G
Laboratory for Experimental Oncology, Indiana University School of Medicine, 699 West Drive, RR 337, Indianapolis, IN 46202-5119, USA. geoweber@iupui.edu
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000633:toxicity*; D004798:Enzymes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D011687:Purines / Q000096:biosynthesis; D011743:Pyrimidines / Q000096:biosynthesis
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D004798:Enzymes; D011687:Purines; D011743:Pyrimidines