[Monoclonal antibodies CD95 in an acute period of ishemic stroke in arterial hypertension].
The data on examination of 83 patients in acute period of cerebral stroke caused by arterial hypertension and 30 healthy controls are presented. In all the patients, content of Fas expressed lymphocytes (CD95), indirectly suggesting apoptosis, has been determined. The level of Fas/Apo-1+ lymphocytes was significantly higher comparing to the control group. Cerebral stroke severity positively correlated with Fas/Apo-1+ lymphocytes. The higher was a level of monoclonal antibodies CD95, the poorer was the course and prognosis both for recovering and for life. This correlation argues for a role of Fas/Apo-1+ lymphocytes in the apoptotic process, and the level of their expression reflects that of apoptosis in damaged brain tissue and serves as a sign of immune inflammation in response to acute cerebral disaster.
Gerasimova
M M
MM
Medvedeva
S L
SL
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000097:blood* / Q000276:immunology; D017209:Apoptosis / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000150:complications / Q000276:immunology* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000276:immunology; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index; D019014:fas Receptor / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D019014:fas Receptor