Magnesium therapy and recovery of function in experimental models of brain injury and neurodegenerative disease.
The role of magnesium (Mg(2+)) in brain injury has been well established. The present paper reviews the use of Mg(2+) therapy to facilitate recovery of function in a focal model of brain injury. Specifically a summary of the ability of magnesium chloride (MgCl(2)) to induce recovery of chronic behavioral impairments and the establishment of MgCl(2)'s wide therapeutic window is presented. These results suggest that Mg(2+) therapy is effective in facilitating recovery of function and exhibits very robust and unique effects.
Hoane
Michael R
MR
Restorative Neuroscience Laboratory, Brain and Cognitive Science Program, Department of Psychology, Southern Illinois University, USA.
D000818:Animals; D001522:Behavior, Animal; D001930:Brain Injuries / Q000188:drug therapy*; D002413:Cations, Divalent; D004195:Disease Models, Animal; D008274:Magnesium / Q000502:physiology*; D015636:Magnesium Chloride / Q000008:administration & dosage*; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000523:psychology; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D011597:Psychomotor Performance; D051381:Rats; D013997:Time Factors
D002413:Cations, Divalent; D018696:Neuroprotective Agents; D015636:Magnesium Chloride; D008274:Magnesium