title: [Postvaccinal antidiphtheria and antitetanus immunity in patients with systemic connective tissue diseases].
abstract: The retrospective evaluation of the intensity of postvaccinal immunity at different periods after the primary course of immunization against diphtheria and tetanus was made. In the sera taken from 130 children with systemic connective tissue diseases the content of antibodies to diphtheria and tetanus was determined. As revealed in this study, the protective levels of antibodies to diphtheria and tetanus toxoids were retained by both sick and healthy children for 5 years and longer. Significantly lower titers of antibodies to diphtheria and tetanus toxoids were registered in children undergoing therapy with glucocorticosteroids and cytostatics at the time of the study.
authors.forename: G V
authors.initials: GV
authors.lastname: Vasil'eva
authors.forename: M P
authors.initials: MP
authors.lastname: Kostinov
authors.forename: G A
authors.initials: GA
authors.lastname: Lyskina
authors.forename: O O
authors.initials: OO
authors.lastname: Magarshak
authors.forename: O V
authors.initials: OV
authors.lastname: Slatinova
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003240:Connective Tissue Diseases / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D004165:Diphtheria / Q000517:prevention & control; D004168:Diphtheria Toxoid / Q000276:immunology; D022422:Diphtheria-Tetanus Vaccine / Q000008:administration & dosage / Q000276:immunology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013742:Tetanus / Q000517:prevention & control; D013745:Tetanus Toxoid / Q000276:immunology; D013997:Time Factors; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D000970:Antineoplastic Agents; D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D005938:Glucocorticoids; D013745:Tetanus Toxoid