Common genetic basis between type 1 and type 2 diabetes mellitus indicated by interview-based assessment of family history.
To investigate the intrafamilial clustering of type 1 and type 2 diabetes, an interview-based assessment of family history of diabetes was conducted. Outpatients with either type 1 (n = 23) or type 2 diabetes (n = 124), and non-diabetic subjects (n = 118) received an interview regarding the diabetic status of each of their family members. In patients with type 1 diabetes, 22% (5 out of 23) had a parental history of diabetes, and diabetes in these 5 parents was assessed as type 2 diabetes mellitus. The prevalence of parental diabetes in the type 1 diabetic probands (22%) was significantly higher (P < 0.05) than that in non-diabetic probands (7%, 8 out of 118). In probands with type 2 diabetes, the prevalence of parental diabetes was 39% (48 out of 124), which was significantly higher (P < 0.0005) than that in the non-diabetic probands (7%). In the type 2 diabetic probands, no significant difference was noted in the prevalence between paternal (19%, 23 out of 124) and maternal diabetes (23%, 28 out of 124), suggesting no preferential inheritance of maternal diabetes in this population. The present interview-based assessment of family history of diabetes suggested a common genetic basis between type 1 and type 2 diabetes.
Fujisawa
Tomomi
T
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan.
Ikegami
Hiroshi
H
Kawaguchi
Yoshihiko
Y
Nojima
Koji
K
Kawabata
Yumiko
Y
Ono
Masaya
M
Nishino
Masanori
M
Noso
Shinsuke
S
Taniguchi
Hidenori
H
Horiki
Mayumi
M
Itoi-Babaya
Michiko
M
Babaya
Naru
N
Inoue
Kaori
K
Ogihara
Toshio
T
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005190:Family; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D007564:Japan / Q000453:epidemiology; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D009679:Nuclear Family; D015995:Prevalence; D012016:Reference Values