title: Clinically evident venous thromboembolic events in children with brain tumors.
abstract: We evaluated the incidence and significance of central venous access device dysfunction and symptomatic major thrombosis in 253 pediatric patients with brain tumors. Central venous access device dysfunction was a common complication (28.4%) and was associated with major thrombosis development and a reduced overall survival rate. Major thrombosis was relatively uncommon (2.8%).
authors.affiliation: Section of Hematology and Coagulation Medicine, Department of Hematology-Medical Oncology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA. sdeitcher@nuvelo.com
authors.forename: Steven R
authors.initials: SR
authors.lastname: Deitcher
authors.forename: Amar
authors.initials: A
authors.lastname: Gajjar
authors.forename: Larry
authors.initials: L
authors.lastname: Kun
authors.forename: Richard L
authors.initials: RL
authors.lastname: Heideman
mesh_terms: D001932:Brain Neoplasms / Q000150:complications* / Q000401:mortality / Q000473:pathology; D002405:Catheterization, Central Venous / Q000295:instrumentation / Q000379:methods*; D002648:Child; D004868:Equipment Failure; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D020246:Venous Thrombosis / Q000209:etiology*