[Role of aggrecanase and MMP in cartilage degradation].
Aritcular cartilage damage results in degradation of macromolecular in cartilage tissue such as aggrecan and type II collagen that are mediated with aggrecanases and matrix metalloproteinases. As the activity of MMP-13 against Type II collagen is very strong, so it plays significant role in cartilage collagen degradation. However, it is noteworthy that the inhibition of both aggrecanse-1. 2 can prevent cartilage degradation. Aggrecan hydrates the collagen network and provides the cartilage tissue with its characteristic pressibility and elasticity. It become now clear that aggrecan plays protective role in preventing degradation of collagen fibrils. Aggrecan and type II collagen molecules cooperatively maintain the cartilage integrity and function.
Ishiguro
Naoki
N
Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine.
Kojima
Toshihisa
T
D051722:ADAM Proteins; D000071121:ADAMTS4 Protein; D000071116:ADAMTS5 Protein; D053674:Aggrecans; D000818:Animals; D002357:Cartilage Diseases / Q000209:etiology / Q000517:prevention & control; D002358:Cartilage, Articular / Q000378:metabolism*; D019902:Chondrocytes / Q000201:enzymology; D024043:Collagen Type II / Q000378:metabolism* / Q000502:physiology; D017364:Collagenases / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D037181:Lectins, C-Type; D053509:Matrix Metalloproteinase 13; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000502:physiology*; D011348:Procollagen N-Endopeptidase; D011509:Proteoglycans / Q000378:metabolism* / Q000502:physiology; D013314:Stress, Mechanical
D053674:Aggrecans; D024043:Collagen Type II; D016326:Extracellular Matrix Proteins; D037181:Lectins, C-Type; D061965:Matrix Metalloproteinase Inhibitors; D011509:Proteoglycans; D051722:ADAM Proteins; D000071116:ADAMTS5 Protein; C121532:ADAMTS5 protein, human; D017364:Collagenases; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13; D008666:Metalloendopeptidases; D011348:Procollagen N-Endopeptidase; D000071121:ADAMTS4 Protein