Hepatic vein anastomotic stricture after living donor liver transplantation.
This report discusses the pathophysiology of and therapeutic methods to address hepatic vein anastomotic stricture after living donor liver transplantation (LDLT). From 1994 to 2002, our 15 LDLTs using the lateral segments or left lobes included four recipients who experienced 28 occurrences of this complication after the operation. The period between LDLT and the first stricture was 4.0 +/- 1.2 months. The age of the affected recipients (31.0 +/- 8.2 years) was significantly higher than that of the nonaffected patients (7.0 +/- 4.1 years, P < .05). Graft liver/standard liver volume ratio was 39.1% +/- 3.8% in the former and 77.9% +/- 12.7% in the latter cases (P < .05). Initial symptoms of stricture were ascites (42.9%), abdominal distention (42.9%), liver enzyme elevation (10.7%), and gastrointestinal bleeding (3.6%). In addition, 14 of 28 stricture cases (50%) showed increased blood trough levels of tacrolimus. Doppler ultrasonography was used for diagnosis, and balloon dilatations performed in all stricture patients, thereby hepatic significantly reducing venous blood pressure from 33.5 +/- 1.7 to 20.3 +/- 1.5 cmH2O. All patients finally resolved the strictures after several treatments. The stricture after LDLT was associated with small-for-size grafts, suggesting that liver regeneration may lead to anatomical changes and strictures. Since tacrolimus is metabolized by the liver, its blood trough level is one initial symptoms of stricture. Balloon dilatation was useful and safe as the treatment, while problems have been reported after stent insertion in the hepatic vein.
Totsuka
E
E
Second Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Japan. etotsuka@cc.hirosaki-u.ac.jp
Hakamada
K
K
Narumi
S
S
Toyoki
Y
Y
Umehara
Y
Y
Okawa
H
H
Tsubo
T
T
Ishihara
H
H
Yoshihara
S
S
Eondoh
M
M
Morita
T
T
Sasaki
M
M
D000328:Adult; D000714:Anastomosis, Surgical; D002404:Catheterization / Q000379:methods; D002648:Child; D005260:Female; D006503:Hepatic Veins / Q000473:pathology*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D013997:Time Factors; D014652:Vascular Diseases / Q000209:etiology* / Q000628:therapy