[The role of insulin receptor substrates in bone metabolism].
IRSs (insulin receptor substrates) are substrates for both insulin and IGF-I receptors. Insulin and IGF-I are known to be bone anabolic factors. IRS-1 deficient mice exhibited severe low turnover osteopenia with decreased bone anabolic and catabolic action, while IRS-2 deficient mice showed osteopenia with decreased anabolic and increased catabolic action. IRS-1 signaling plays an important role for maintaining bone turnover while IRS-2 signaling maintains anabolic balance in osteoblasts.
Akune
Toru
T
Department of Orthopaedic Surgery, Kanto Medical Center NTT E.C.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D055504:Insulin Receptor Substrate Proteins; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D010750:Phosphoproteins / Q000502:physiology*
D055504:Insulin Receptor Substrate Proteins; D047908:Intracellular Signaling Peptides and Proteins; C526295:Irs1 protein, mouse; C526298:Irs2 protein, mouse; D010750:Phosphoproteins