The DNA-polymerase-X family: controllers of DNA quality?
Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.
Ramadan
Kristijan
K
Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich, Winterthurerstrasse 190, CH 8057 Zürich, Switzerland.
Shevelev
Igor
I
Hübscher
Ulrich
U
D000818:Animals; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D005810:Multigene Family; D009690:Nucleic Acid Conformation; D011487:Protein Conformation
D004247:DNA; C109534:DNA polymerase X; D004259:DNA-Directed DNA Polymerase