title: Chemical constituents from the Colombian medicinal plant Maytenus laevis.
abstract: The methanol extract of the bark of the Colombian medicinal plant Maytenus laevis gave six new compounds and 28 known compounds. The structures of the new and known compounds were elucidated on the basis of spectroscopic evidence. Several of these compounds were screened for cytokine-inducing activity on human PBMCs to investigate antitumor effects, and canophyllol (12) demonstrated the most effective induction of the cytokines.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi, Tokushima 770-8505, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Carmenza
authors.initials: C
authors.lastname: Duque
authors.forename: Cristina
authors.initials: C
authors.lastname: Garzon
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Sato
authors.forename: Masato
authors.initials: M
authors.lastname: Okamoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Oshikawa
authors.forename: Sharif Uddin
authors.initials: SU
authors.lastname: Ahmed
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003105:Colombia; D016207:Cytokines / Q000096:biosynthesis; D004354:Drug Screening Assays, Antitumor; D006680:HLA Antigens; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D029755:Maytenus / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D016207:Cytokines; D006680:HLA Antigens