Effect of alpha-tocopherol supplementation on blood pressure and lipidic profile in streptozotocin-induced diabetes mellitus in spontaneously hypertensive rats.
BACKGROUND
Antioxidants has been utilized to prevent oxidative damage in diabetes and hypertensive diseases. The current study evaluated the effect of alpha-tocopherol supplementation on blood pressure and the lipid profile in streptozotocin-induced diabetes mellitus in spontaneously hypertensive rats (SHR).


METHODS
The systolic blood pressure and total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were measured in SHR-diabetes induced.


RESULTS
Treatment with alpha-tocopherol (vitamin E) led to a decrease on systolic blood pressure and showed an increase of HDL-cholesterol and a decrease of LDL-cholesterol, but the concentrations of triglycerides and total cholesterol were not changed.


CONCLUSIONS
The vitamin E was able to modulate the blood pressure and the lipidic profile as well, and therefore can be considered as an alternative treatment of lipid disorder found on diabetes and hypertension diseases.
Vieira da Costa
Virginia Alice
VA
Laboratory of Nutritional Investigation and Degenerative-Chronic Diseases, Federal University of Rio de Janeiro State, Brazil.
Vianna
Lucia Marques
LM
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000503:physiopathology*; D004032:Diet; D019587:Dietary Supplements; D006973:Hypertension / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D008055:Lipids / Q000097:blood*; D051381:Rats; D011918:Rats, Inbred SHR; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D014810:Vitamin E; D002784:Cholesterol