[Afobazole increases cerebral blood flow in rats with global brain ischemia].
The selective anxiolytic drug afobazole administered in a dose of 5 mg/kg increased the cerebral blood flow in rats. The effect was more pronounced in rats with global reversible cerebral ischemia than in intact animals. The ischemia model was caused by occlusion of both common carotid arteries for 120 min with simultaneous reduction of the arterial pressure to 40-50 mm Hg through blood-letting. Afobazole also significantly increased the survival of rats with cerebral ischemia model caused by ligation of both common carotid arteries, which was evidence of the neuroprotector activity. Apparently, the ability of afobazole to improve the cerebral blood flow in ischemized rat brain is an important factor in realization of the neuroprotector activity.
Silkina
I V
IV
Aleksandrin
V V
VV
Gan'shina
T C
TC
Seredin
S B
SB
Mirzoian
R S
RS
D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000401:mortality; D017536:Carotid Artery, Common; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D008026:Ligation; D009025:Morpholines / Q000008:administration & dosage*; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D051381:Rats
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D009025:Morpholines; D018696:Neuroprotective Agents