title: Flexible automation of cell culture and tissue engineering tasks.
abstract: Until now, the predominant use cases of industrial robots have been routine handling tasks in the automotive industry. In biotechnology and tissue engineering, in contrast, only very few tasks have been automated with robots. New developments in robot platform and robot sensor technology, however, make it possible to automate plants that largely depend on human interaction with the production process, e.g., for material and cell culture fluid handling, transportation, operation of equipment, and maintenance. In this paper we present a robot system that lends itself to automating routine tasks in biotechnology but also has the potential to automate other production facilities that are similar in process structure. After motivating the design goals, we describe the system and its operation, illustrate sample runs, and give an assessment of the advantages. We conclude this paper by giving an outlook on possible further developments.
authors.affiliation: Department of Informatics, Technische Universität München, Boltzmannstrasse 3, 85748 Garching, Germany. knoll@in.tum.de
authors.forename: Alois
authors.initials: A
authors.lastname: Knoll
authors.forename: Torsten
authors.initials: T
authors.lastname: Scherer
authors.forename: Iris
authors.initials: I
authors.lastname: Poggendorf
authors.forename: Dirk
authors.initials: D
authors.lastname: Lütkemeyer
authors.forename: Jürgen
authors.initials: J
authors.lastname: Lehmann
mesh_terms: D001185:Artificial Intelligence; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008846:Micromanipulation / Q000295:instrumentation* / Q000379:methods; D012371:Robotics / Q000295:instrumentation* / Q000379:methods; D013048:Specimen Handling / Q000295:instrumentation* / Q000379:methods; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods