A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction.
A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The MIP was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the MIP was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.
Caro
Ester
E
Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, Imperial Tarraco 1, 43005 Tarragona, Spain.
Marcé
Rosa M
RM
Cormack
Peter A G
PA
Sherrington
David C
DC
Borrull
Francesc
F
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000652:urine*; D002853:Chromatography, Liquid; D009288:Naproxen / Q000652:urine*; D011108:Polymers / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011108:Polymers; D009288:Naproxen