title: Localised vulva Langerhans cell histiocytosis.
abstract: A cutaneous lesion as sole manifestation of adult Langerhans cell histiocytosis is rare. We report a 65-year old female who presented with vulvar ulcers. Histological examination of the ulcer showed diffuse proliferation of histiocytic cells with large bright cytoplasm that were positively stained for anti-S-100 protein and anti-CD1a antibodies by immunohistochemistry. Electron microscopy demonstrated Birbeck granules in the cytoplasm of the cells. Since there was no other organ involvement, the patient was treated by complete surgical excision without recurrence or other-organ involvement in the 1-year follow-up period.
authors.affiliation: Department of Dermatology, Kanazawa University School of Medicine, 13-1 Takaramachi, Kanazawa, 920-8641 Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Ishigaki
authors.forename: Naohito
authors.initials: N
authors.lastname: Hatta
authors.forename: Mizuki
authors.initials: M
authors.lastname: Yamada
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Orito
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Takehara
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D014845:Vulvar Diseases / Q000175:diagnosis* / Q000473:pathology