title: Voriconazole-induced retinoid-like photosensitivity in children.
abstract: Voriconazole is a new triazole antifungal agent with activity against a wide range of systemic fungal pathogens, including Aspergillus spp. Photosensitivity is a rarely reported side effect of voriconazole, hypothesized to be a result of retinoid-like effects. We report two children with chronic granulomatous disease to whom voriconazole was administered for chronic invasive aspergillosis. Severe photosensitivity occurred in both patients, one of whom had striking photodamage at the 5-month follow-up.
authors.affiliation: Department of Dermatology, Texas Children's Hospital, Baylor College of Medicine, 6621 Fannin St., Houston, TX 77030-2399, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Rubenstein
authors.forename: Moise L
authors.initials: ML
authors.lastname: Levy
authors.forename: Denise
authors.initials: D
authors.lastname: Metry
mesh_terms: D000293:Adolescent; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D006105:Granulomatous Disease, Chronic / Q000188:drug therapy; D006801:Humans; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D011379:Prognosis; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D012176:Retinoids / Q000494:pharmacology; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D012176:Retinoids; D014230:Triazoles; D065819:Voriconazole