Mph2 expression in germinal zones of the mouse brain.
The telencephalon develops from a seemingly homogeneous population of precursor cells that generates neurons with divergent properties and cell fates. An important question concerns the genetic control of cell states belonging to different generations. Mph2 was identified by serial analysis of gene expression as a differentially expressed gene during cortical development. Belonging to the Polycomb group, Mph2 may be involved in transcriptional repression of cell states from one generation to the next. Here, we use in situ hybridization to determine the spatial localization of Mph2 expression in the developing nervous system. Mph2 expression evident in proliferating precursor cell populations in the developing mouse brain such as the ventricular zones of the cortex and ganglionic eminences as well as in mature structures such as the granule cell layer of the adult dentate gyrus and cerebellum indicates a role for Mph2 in both the developing and adult brain.
Kim
Mary H
MH
Brain Development Laboratory, Howard Florey Institute, The University of Melbourne, Parkville, Victoria, Australia.
Gunnersen
Jenny M
JM
Tan
Seong-Seng
SS
D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000196:embryology*; D019070:Cell Lineage; D049109:Cell Proliferation; D002531:Cerebellum / Q000196:embryology; D018891:Dentate Gyrus / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000096:biosynthesis* / Q000235:genetics* / Q000502:physiology; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D051379:Mice; D008810:Mice, Inbred C57BL; D009420:Nervous System / Q000196:embryology; D009474:Neurons / Q000378:metabolism; D009687:Nuclear Proteins / Q000502:physiology*; D063151:Polycomb Repressive Complex 2; D016548:Prosencephalon / Q000196:embryology; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics* / Q000502:physiology*; D014158:Transcription, Genetic
D018398:Homeodomain Proteins; D009687:Nuclear Proteins; C485977:PHC2 protein, human; C501292:Phc2 protein, mouse; D014157:Transcription Factors; D063151:Polycomb Repressive Complex 2