title: Long-term treatment of menorrhagia with levonorgestrel intrauterine system versus endometrial resection.
abstract: OBJECTIVE
  The purpose of this study was to compare the long-term efficacy of the levonorgestrel intrauterine system and transcervical resection of the endometrium in the treatment of menorrhagia.
  
  
  METHODS
  This study was an open, randomized 3-year trial. Patients with menorrhagia were assigned randomly to either the levonorgestrel intrauterine system (n = 30) or endometrial resection (n = 29). Pictorial blood loss assessment charts were used to measure menstrual blood loss. A pictorial blood-loss assessment chart score exceeding 75 (representing menstrual blood loss >/=60 mL) was used to diagnosis the patient as having menorrhagia. Discontinuations and cases requiring repeat operations were evaluated.
  
  
  RESULTS
  Pictorial blood loss scores decreased from a baseline median of 261.5 (range, 60-1503) to 7 (range, 0-101; P < .001) for the levonorgestrel intrauterine system and from 311 (range, 81-2506) to 4 (range, 0-182; P < .001) for transcervical resection of the endometrium. Nineteen women of 30 using the levonorgestrel intrauterine system completed the 3-year follow-up compared with 22 of 29 for transcervical resection of the endometrium.
  
  
  CONCLUSIONS
  Both treatments efficiently reduced menstrual bleeding. The high continuation rate suggests that the levonorgestrel intrauterine system is comparable with transcervical resection of the endometrium.
authors.affiliation: The Finnish Medical Society Duodecim, Helsinki, Finland. ilkka.rauramo@duodecim.fi
authors.forename: Ilkka
authors.initials: I
authors.lastname: Rauramo
authors.forename: Iina
authors.initials: I
authors.lastname: Elo
authors.forename: Olav
authors.initials: O
authors.lastname: Istre
mesh_terms: D000328:Adult; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000627:therapeutic use*; D004717:Endometrium / Q000601:surgery*; D005260:Female; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage / Q000627:therapeutic use*; D008595:Menorrhagia / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D008875:Middle Aged; D013997:Time Factors
chemical_list: D003271:Contraceptive Agents, Female; D006454:Hemoglobins; D016912:Levonorgestrel; D005293:Ferritins