Value of albumin dialysis therapy in severe liver insufficiency.
A blood purification system, molecular adsorbents re-circulating system (MARS), is based on the removal of both protein-bound and water-soluble substances and toxins in the liver. We treated a total of 88 patients within 2 years. Of these patients, 45 had acute liver failure (ALF), 31 had acute decompensation of chronic liver disease, eight had graft failure and four had miscellaneous conditions. Of the patients with ALF, 80% survived; in 23 patients their own liver recovered and 13 patients underwent successful transplantation. Only 23% of patients with acute-on-chronic liver failure survived. Most of them were not considered for transplantation due to their having liver failure from alcoholism and from not abstaining from drinking. MARS is a promising therapy for ALF, allowing the patient's own liver to recover or allowing enough time to find a liver graft. Best results were achieved in patients who had been intoxicated with a lethal dose of toxin. On the other hand, we did not observe much benefit in patients with severe acute-on-chronic liver failure (AcoChr) who did not undergo liver transplantation.
Lahdenperä
Arttu
A
Department of Anaesthesiology and Intensive Care, Helsinki University Hospital, Helsinki, Finland.
Koivusalo
Anna-Maria
AM
Vakkuri
Anne
A
Höckerstedt
Krister
K
Isoniemi
Helena
H
D000208:Acute Disease; D000328:Adult; D000418:Albumins / Q000627:therapeutic use*; D002908:Chronic Disease; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000503:physiopathology / Q000628:therapy; D017093:Liver Failure / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation; D008875:Middle Aged; D020127:Recovery of Function; D012189:Retrospective Studies; D016060:Sorption Detoxification; D016019:Survival Analysis
D000418:Albumins