[An experimental study on PLGA carrier for oral tissue engineered mucosa by subcutaneous implantation in rabbits].
OBJECTIVE
To look for the best carrier for cultivating oral tissue engineered mucosa.


METHODS
A series of membrane of scaffold materials of polycleclide-co-plycoclide (PLGA) were studied on their weight and biocompatibility after they had been implanted subcutaneously in rabbits for 1, 2, 3, 4 weeks respectively.


RESULTS
PLGA I , II, III degraded completely in rabbits after 2, 3, 4 weeks respectively. The other PLGA membrane degraded about 50% after 4 weeks. Histologically, the reactions of PLGA I, II, III with surrounding tissues were normal and membranes had a good biocompatibility.


CONCLUSIONS
The biodegrading rate of PLGA II is suitable for clinic practice. PLGA II was a promising carrier for oral tissue-engineered mucosa due to its excellent biocompatibility and biodegrading rate.
Qi
Bing
B
Dept. of Oral Pathology, Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China.
Li
Hong-wei
HW
Wen
Yu-ming
YM
Wang
Chang-mei
CM
Li
Long-jiang
LJ
Song
Xiao-ling
XL
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials; D002478:Cells, Cultured; D005260:Female; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D009061:Mouth Mucosa / Q000166:cytology* / Q000378:metabolism; D011100:Polyglycolic Acid / Q000378:metabolism*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000378:metabolism*; D011817:Rabbits; D023822:Tissue Engineering
D001672:Biocompatible Materials; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid