The effect of erroneous responses on response monitoring in patients with major depressive disorder: a study with event-related potentials.
Perceived failure is reported to have detrimental effects on subsequent performance in patients with major depressive disorder. We investigated the error-related negativity (ERN)/error negativity (Ne), an electrophysiological correlate of response monitoring, using a 64-channel EEG. Sixteen patients with DSM-IV major depressive disorder and 16 matched controls participated in an Eriksen flanker task with continuous performance feedback that signaled monetary reward. Compared to controls, patients with major depressive disorder showed a less negative ERN/Ne in error trials following error trials. This result might reflect impaired response monitoring processes in major depressive disorder resulting from an underactivity in a central reward pathway and/or a deficit in strategic reasoning.
Ruchsow
Martin
M
Department of Psychiatry, University of Ulm, Ulm, Germany. martin.ruchsow@medizin.uni-ulm.de
Herrnberger
Bärbel
B
Wiesend
Christiane
C
Grön
Georg
G
Spitzer
Manfred
M
Kiefer
Markus
M
D000328:Adult; D003072:Cognition Disorders / Q000503:physiopathology / Q000523:psychology; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology*; D012201:Reward