[Thrombocytic dysfunctions and potentialities of their differential correction in chronic viral hepatitis].
The paper presents the results of examination in 88 patients with chronic viral hepatitis (CVH), the parameters of spontaneous and induced platelet aggregation (IPA), cyclic nucleotides (cAMP and cHMP) in the platelets, and the plasma levels of thrombocyte-specific peptides--beta-thromboglobulin and thrombocytic factor IV in dynamics of the first administration of alpha-interferon (alpha-IFN) and 24-week interferon therapy. According to the values of IPA, the patients with CVH are a heterogeneous group with a predominance of cases of diminished aggregation. The first administration of alpha-IFN causes heterodirectional changes in the functional activity of platelets with a general tendency for their normalization. Supplementation of curantyl in case of increased IPA leads to a more rapid and profound normalization of platelet activity, which is of value in cases at risk for thrombotic complications.
Iagoda
A V
AV
Koroĭ
P V
PV
D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002908:Chronic Disease; D004176:Dipyridamole / Q000494:pharmacology*; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood*; D019698:Hepatitis C, Chronic / Q000097:blood*; D019701:Hepatitis D, Chronic / Q000097:blood*; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D012307:Risk Factors; D013927:Thrombosis / Q000517:prevention & control
D000998:Antiviral Agents; D016898:Interferon-alpha; D010975:Platelet Aggregation Inhibitors; D004176:Dipyridamole