title: The involvement of the interstitial Cajal cells and the enteric nervous system in bowel endometriosis.
abstract: BACKGROUND
  Our aim was to investigate the relationships between gastrointestinal symptoms and histological findings in women with bowel endometriosis.
  
  
  METHODS
  The gastrointestinal symptoms of 362 women with endometriosis were classified according to the subgroups of the Rome II criteria. All visible endometriotic lesions of the bowel were removed; the patients were prospectively followed up for 2 years. The interstitial Cajal cells (ICC) and the enteric nervous system were immunohistochemically evaluated.
  
  
  RESULTS
  Sixty-eight (18.8%, 95% CI 14.9-23.2) women had bowel lesions. The endometriotic lesions infiltrated the serosal layer and surrounding connective tissue in 45 cases; the subserous plexus in 11 cases; the Auerbach plexus in eight cases; the Meissner plexus in four cases. Whenever the subserous plexus was interrupted by the endometriotic lesions, the ICC were damaged. All women with endometriotic lesions reaching at least the subserous plexus reported bowel complaints. The level of infiltration into the bowel wall was correlated with severity of symptoms. Removal of lesions resulted in improvement of symptoms.
  
  
  CONCLUSIONS
  Endometriosis-induced damage of ICC, even before muscular infiltration, may cause bowel symptoms.
authors.affiliation: Department of Obstetrics and Gynaecology, Department of General Surgery and Transplant, San Martino Hospital, University of Genoa, Largo R.Benzi 1, 16132 Genoa, Italy. vremorgida@yahoo.it
authors.forename: V
authors.initials: V
authors.lastname: Remorgida
authors.forename: N
authors.initials: N
authors.lastname: Ragni
authors.forename: S
authors.initials: S
authors.lastname: Ferrero
authors.forename: P
authors.initials: P
authors.lastname: Anserini
authors.forename: P
authors.initials: P
authors.lastname: Torelli
authors.forename: E
authors.initials: E
authors.lastname: Fulcheri
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D017615:Enteric Nervous System / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009197:Myenteric Plexus / Q000473:pathology / Q000503:physiopathology; D010146:Pain / Q000503:physiopathology; D011446:Prospective Studies; D013368:Submucous Plexus / Q000473:pathology / Q000503:physiopathology