title: Dietary fiber suppresses elevation of uric acid and urea nitrogen concentrations in serum of rats with renal dysfunction induced by dietary adenine.
abstract: This study was conducted to examine the effects of several kinds of dietary fiber (DF) with different physical properties on the elevation of uric acid and urea nitrogen concentrations in serum of rats induced by dietary adenine. DF decreased an uptake of 14C-labeled adenine in the rat jejunum in vitro, but the reduction varied with the physical property of DF. Male Wistar rats (3 weeks old) were fed a diet with or without a 0.4% adenine and a 5% DF (cellulose, chitin, chitosan, or xanthan gum) for 20 days. Feeding of adenine in the fiber-free group elevated the concentrations of uric acid, creatinine, and urea nitrogen in serum, but decreased the excretions of these compounds into urine and increased the amounts of 2,8-dihydroxyadenine (2,8-DHA) in kidney and urine. The test DF was found to suppress the elevation of uric acid, creatinine, and urea nitrogen concentrations in serum induced by dietary adenine, and to mitigate the decreased excretions of these compounds into urine and the increased retention of 2,8-DHA in kidney and urine. This phenomenon was remarkable in the xanthan gum group. These results suggest that DF suppresses the elevation of uric acid and urea nitrogen concentrations in serum by attenuating the absorption of dietary adenine.
authors.affiliation: Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Koguchi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Koguchi
authors.forename: Hisao
authors.initials: H
authors.lastname: Nakajima
authors.forename: Saburo
authors.initials: S
authors.lastname: Takano
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Innami
authors.forename: Akio
authors.initials: A
authors.lastname: Maekawa
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Tadokoro
mesh_terms: D000225:Adenine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics / Q000652:urine; D000818:Animals; D001806:Blood Urea Nitrogen; D002482:Cellulose / Q000008:administration & dosage / Q000737:chemistry; D002686:Chitin / Q000008:administration & dosage / Q000737:chemistry; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry; D003404:Creatinine / Q000097:blood; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage* / Q000032:analysis; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism; D007668:Kidney / Q000737:chemistry; D007674:Kidney Diseases / Q000097:blood* / Q000139:chemically induced; D007958:Leukocyte Count; D008297:Male; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D014527:Uric Acid / Q000097:blood*; D015430:Weight Gain
chemical_list: D004043:Dietary Fiber; D002686:Chitin; D014527:Uric Acid; C002993:2,8-dihydroxyadenine; D002482:Cellulose; D048271:Chitosan; D003404:Creatinine; D000225:Adenine