title: A new glucosyl feruloyl quinic acid as a potential marker for roots and rhizomes of goldenseal, Hydrastis canadensis.
abstract: A new compound, 5-O-(4'-[beta-d-glucopyranosyl]-trans-feruloyl)quinic acid (GPFQ, 10), is reported from the medicinal plant goldenseal (Hydrastis canadensis). A new HPLC method is described and used to show that GPFQ is a potential marker for goldenseal roots (1.0% w/w) and rhizomes (2.3%). GPFQ was found at much lower levels in stems (<0.1%) and could not be detected in leaves. Neochlorogenic acid (9), which has not previously been reported from goldenseal, and chlorogenic acid (6) reached their highest levels in leaves (0.9% 9 and 0.5% 6). The main alkaloids, hydrastine (1) and berberine (2), were highest in rhizomes (2.8% 1 and 4.6% 2), but palmatine (5) was not found in genuine goldenseal.
authors.affiliation: New Zealand Institute for Crop & Food Research Limited, Plant Extracts Research Unit, Department of Chemistry, University of Otago, Box 56, Dunedin, New Zealand.
authors.forename: Catherine E
authors.initials: CE
authors.lastname: McNamara
authors.forename: Nigel B
authors.initials: NB
authors.lastname: Perry
authors.forename: John M
authors.initials: JM
authors.lastname: Follett
authors.forename: Graeme A
authors.initials: GA
authors.lastname: Parmenter
authors.forename: James A
authors.initials: JA
authors.lastname: Douglas
mesh_terms: D000465:Algorithms; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D044182:Benzylisoquinolines; D001600:Berberine Alkaloids / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D015415:Biomarkers / Q000032:analysis; D002726:Chlorogenic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D039321:Hydrastis / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009520:New Zealand; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: C495044:5-O-(4'-(beta-D-glucopyranosyl)-trans-feruloyl)quinic acid; D000470:Alkaloids; D044182:Benzylisoquinolines; D001600:Berberine Alkaloids; D015415:Biomarkers; D002726:Chlorogenic Acid; C013024:hydrastine