title: [Pathological development of researches on intervertebral disc degeneration].
abstract: This article reviews the literature about the etiology and pathology of intervertebral disc degeneration. The degeneration of intervertebral disc is associated with certain biomechanical factor. Stress can directly lead to the rupture of intervertebral disc and, more importantly, change its biological properties. And then, it can trigger the process of degeneration via inflammatory mechanism which may include autoimmunity.
authors.affiliation: Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Feng
authors.forename: Yueming
authors.initials: Y
authors.lastname: Song
mesh_terms: D001696:Biomechanical Phenomena; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology*; D007405:Intervertebral Disc Displacement / Q000209:etiology* / Q000473:pathology