title: [The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats].
abstract: OBJECTIVE
  To investigate the effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats.
  
  
  METHODS
  Thirty male SD rats were randomly divided into three groups: control group, hypoxic group and therapeutic group. The animal model of pulmonary hypertension was established by exposing the rats to normabaric hypoxic conditions for three weeks. Then, the therapeutic group was given losartan for two weeks. We measured the expression of Collagen I, III and AT1 in arterioles by means of immunohistochemistry.
  
  
  RESULTS
  The positive degree of Collagen I in pulmonary arterioles in the hypoxic group was higher than that in the control group [(1.5202+/-0.069) vs (1.1324+/-0.071), P<0.01]; but in the therapeutic group it was lower than that in the hypoxic group [(1.1637+/-0.062) vs (1.5202+/-0.069), P<0.01]. There was no significant difference in collagen III and AT1 among the three groups (P>0.05).
  
  
  CONCLUSIONS
  Losartan could reduce pulmonary arterial collagen I expression, it may be one of the therapeutic mechanisms on hypoxic pulmonary hypertension of losartan.
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Guan
authors.forename: De-yun
authors.initials: DY
authors.lastname: Cheng
authors.forename: Xiao-ju
authors.initials: XJ
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Qiao-li
authors.initials: QL
authors.lastname: Su
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000818:Animals; D002908:Chronic Disease; D003094:Collagen / Q000096:biosynthesis* / Q000235:genetics; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D000860:Hypoxia / Q000150:complications / Q000378:metabolism*; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D011651:Pulmonary Artery / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D044140:Receptor, Angiotensin, Type 1 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D044140:Receptor, Angiotensin, Type 1; D003094:Collagen; D019808:Losartan