Effect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR rats.
We studied the effects of spontaneous high blood pressure and the captopril treatment on the subfornical organ (SFO) of rats. The brains of control Wistar-Kyoto rats (WKY), WKY rats treated with captopril (WKY-T), spontaneously hypertensive rats (SHR) and SHR rats treated with captopril (SHR-T) were processed immunohistochemically using anti-angiotensin II as primary antibody. Immunorective material (IRM) for angiotensin II was observed in a group of neurons and some cells of the ependymal layer of the SFO in WKY rats. The angiotensin II immunoreactive (AGII-ir) in the SHR rats was decreased, showing positive reaction only in a few neurons, while captopril treatment induced an increase in immunoreactive material in hypertensive rats, but contrarily, the expression of AGII-ir in the WKY-T group was scarce. The variations of the angiotensin II observed in the SFO could be owing to an interaction between the hypertension and its captopril treatment.
Carmona-Calero
E M
EM
Departamento de Anatomía, Facultad de Medicina, Universidad de La Laguna, Tenerife, Spain. ecarmona@ull.es
Perez-Gonzalez
H
H
Martinez-Peña Y Valenzuela
I
I
Gonzalez-Marrero
I
I
Perez-Garcia
C G
CG
Marrero-Gordillo
N
N
Ormazabal-Ramos
C
C
Castañeyra-Perdomo
A
A
Ferres-Torres
R
R
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002216:Captopril / Q000494:pharmacology*; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D013356:Subfornical Organ / Q000187:drug effects* / Q000378:metabolism
D000959:Antihypertensive Agents; D000804:Angiotensin II; D002216:Captopril