title: Controlled porosity osmotic pumps of highly aqueous soluble drug containing hydrophilic polymers as release retardants.
abstract: Controlled porosity osmotic pumps (CPOPs) are devoid of delivery orifice to release core contents and essentially possess pore-forming agent(s) in coating composition. When the pump comes in contact with aqueous media, pore-forming agent(s) generate pores through which core contents are delivered. Diltiazem hydrochloride (DLTZ) is a freely water-soluble drug and the release rates of DLTZ are higher from oral osmotic pumps including CPOPs, in which the drug release is controlled by concentration of pore-forming agents. The effect of appropriate concentration of hydroxypropyl methyl cellulose and sodium carboxy methyl cellulose mixture on the release of DLTZ from CPOPs was studied. In vitro drug release profiles were compared with that of different marketed controlled release formulations and statistically analysed to examine the suitability of CPOP for twice or once daily administration. Dissolution models were applied to drug release data in order to establish the mechanism of drug release and kinetics. Drug release from the CPOPs was effectively modified with the concentration of pore-forming agent in membrane and concentration of hydrophilic polymers in the core. CPOPs showed minimum 65% of consistent DLTZ release at 16 h. Statistical analysis confirmed that with an increase in the amount of hydrophilic polymers release rate decreased. Drug release from the systems follows Hixson-Crowell cube root model and mechanism of release follow non-Fickian diffusion.
authors.affiliation: Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr Harisingh Gour University, Sagar [MP], India.
authors.forename: D
authors.initials: D
authors.lastname: Prabakaran
authors.forename: Paramjit
authors.initials: P
authors.lastname: Singh
authors.forename: Parijat
authors.initials: P
authors.lastname: Kanaujia
authors.forename: Vivek
authors.initials: V
authors.lastname: Mishra
authors.forename: K S
authors.initials: KS
authors.lastname: Jaganathan
authors.forename: Suresh P
authors.initials: SP
authors.lastname: Vyas
mesh_terms: D002266:Carboxymethylcellulose Sodium / Q000737:chemistry / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003627:Data Interpretation, Statistical; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics*; D004110:Diltiazem / Q000032:analysis / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000138:chemical synthesis / Q000493:pharmacokinetics; D004355:Drug Stability; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D009995:Osmosis; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics*; D016062:Porosity; D012995:Solubility / Q000187:drug effects*; D014867:Water
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011108:Polymers; D014867:Water; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D004110:Diltiazem; D002266:Carboxymethylcellulose Sodium