[Comparison of pelvic transarterial chemoembolization with lipiodol ultra-fluid carboplatin and transarterial carboplatin through experiment in dogs].
OBJECTIVE
Transarterial chemoembolization, based on transarterial chemotherapy, is a new treatment for malignant neoplasms. This study was to investigate distribution of platinum (Pt) in blood and uterine tissue after infusing different carboplatin arterially.


METHODS
Fourteen female dogs were randomly divided into 2 groups: embolizational group (group A, 7 dogs),and chemotherapy group (group B, 7 dogs). In group A, carboplatin (12 mg/kg), mingled with lipidol ultra-fluid (0.2 ml/kg), was injected into dogs' iliac arteries. In group B, carboplatin (12 mg/kg), dissolved in 5% glucose, was injected into the same arteries. The uterine tissues and blood samples were collected at different time points, concentrations of Pt in samples were measured by atomic absorption method.


RESULTS
Peak concentration of Pt in uterine tissues of group A was (215.0+/-17.6) microg/g, that of group B was (211.3+/-40.1) microg/g (P >0.05), the peak appeared at 0 min in both groups. Area under concentration-time curve (AUC) of Pt in tissues of group A was (13.9+/-3.9) mg x min x g(-1), significantly larger than that of group B (5.9+/-0.6) mg x min x g(-1). Peak concentration of Pt in plasma of group A was (8.7+/-12.5) microg/g, that of group B was (16.7+/-3.6) microg/g. AUC(0-240 min) was (0.5+/-0.1) mg x min x g(-1) in group A,and (1.2+/-0.4) mg x min x g(-1) in group B (P< 0.05).


CONCLUSIONS
Compared with arterial chemotherapy, arterial chemo- embolization may result in higher Pt concentration in local area, and lower Pt concentration in plasma, it may reduce the systemic toxicities, and enhance local effect on tumor.
Chen
Chun-Lin
CL
Department of Obstetrics and Gynecology, The First Municipal People's Hospital of Guangzhou City, Guangzhou,Guangdong, 510180, P.R.China. jieru@163.com
Sun
Ming-Hui
MH
Tan
Dao-Cai
DC
Liang
Li-Zhi
LZ
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D016190:Carboplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016461:Chemoembolization, Therapeutic; D004285:Dogs; D005260:Female; D007083:Iliac Artery; D007261:Infusions, Intra-Arterial; D007459:Iodized Oil; D010984:Platinum / Q000097:blood / Q000378:metabolism; D011897:Random Allocation; D014599:Uterus / Q000378:metabolism
D000970:Antineoplastic Agents; D010984:Platinum; D007459:Iodized Oil; D016190:Carboplatin