title: Virucidal activity presence in Trichilia glabra leaves.
abstract: Different immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were investigated. Methanolic fraction extracts were active against herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV), while no activity against poliovirus type 3 was observed. VSV was slightly more affected than HSV-1: 2.8 log10 reduction in VSV titer against 2.4 log10 reduction in HSV-1 titer when 0.25 mg/ml F2 fraction was tested and a reduction of 2.7 log10 in VSV virus titer and of 1.5 log10 in HSV-1 virus titer was observed when 0.25 mg/ml F3 fraction was tested. Results obtained in this work suggest a potential pharmaceutical use of TG extract components.
authors.affiliation: CEFYBO, Serrano 669, 1414, Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Cella
authors.forename: D A
authors.initials: DA
authors.lastname: Riva
authors.forename: F C
authors.initials: FC
authors.lastname: Coulombié
authors.forename: S E
authors.initials: SE
authors.lastname: Mersich
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005591:Chemical Fractionation; D002522:Chlorocebus aethiops; D002725:Chloroform; D018259:Herpesvirus 1, Human / Q000187:drug effects; D029582:Meliaceae / Q000737:chemistry*; D000432:Methanol; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D017955:Poliovirus / Q000187:drug effects; D014709:Vero Cells; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts; D002725:Chloroform; D000432:Methanol