Entorhinal cortex contributes to object-in-place scene memory.
Four rhesus monkeys (Macaca mulatta) were trained preoperatively in a test of object-in-place scene memory. They were presented daily with lists of unique computer-generated scenes each containing a spatial array of multiple individual objects. Within each scene, objects to be discriminated appeared in the foreground, each occupying a unique location, and monkeys were required to correctly discriminate the rewarded object to receive a food reward. Once this preoperative criterion was attained, the monkeys received bilateral entorhinal cortex ablation performed as either one or two surgical operations with a period of testing following each. Postoperatively, they were significantly impaired in learning new object-in-place scene problems. These results show that the entorhinal cortex, like anatomically related structures including the perirhinal cortex and the fornix, contributes to object-in-place scene learning.
Charles
David P
DP
Department of Experimental Psychology, Oxford University, South Parks Road, Oxford OX1 3UD, UK. david.charles@psy.ox.ac.uk
Browning
Philip G F
PG
Gaffan
David
D
D000818:Animals; D001522:Behavior, Animal; D001931:Brain Mapping; D017115:Catheter Ablation / Q000379:methods; D003216:Conditioning, Operant / Q000502:physiology; D004193:Discrimination Learning / Q000502:physiology; D018728:Entorhinal Cortex / Q000502:physiology*; D020712:Fornix, Brain / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D008253:Macaca mulatta; D008297:Male; D008568:Memory / Q000502:physiology*; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D012201:Reward