COMT Val(158)Met and BDNF C(270)T polymorphisms in schizophrenia: a case-control study.
In a multicenter study involving 217 subjects of European ancestry [106 patients with schizophrenia and 111 healthy subjects], we tested the hypothesis that the catechol-O-methyl transferase (COMT) Val(158)Met and/or the brain-derived neurotrophic factor (BDNF) C(270)T gene polymorphisms are associated with schizophrenia. The COMT and BDNF genotype and their allele distribution did not differ between patients with schizophrenia and healthy comparison subjects. These results do not support the hypothesis that the COMT Val(158)Met or BDNF C(270)T gene polymorphisms are associated with liability to schizophrenia.
Galderisi
Silvana
S
Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie 1, 80138 Naples, Italy. sgalderi@tin.it
Maj
Mario
M
Kirkpatrick
Brian
B
Piccardi
Paola
P
Mucci
Armida
A
Invernizzi
Giordano
G
Rossi
Alessandro
A
Pini
Stefano
S
Vita
Antonio
A
Cassano
Paolo
P
Stratta
Paolo
P
Severino
Giovanni
G
Del Zompo
Maria
M
D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D008040:Genetic Linkage / Q000235:genetics; D005838:Genotype; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
D019208:Brain-Derived Neurotrophic Factor; D009419:Nerve Tissue Proteins; D002394:Catechol O-Methyltransferase