Single-fiber EMG in familial hemiplegic migraine.
Twelve familial hemiplegic migraine (FHM) patients (6 with the I1811L mutation in CACNA1A, 3 with M731T mutation in ATP1A2, and 3 without known mutations) and 10 control subjects underwent single-fiber EMG. Mean jitter did not differ significantly between patients and control subjects or among patients. No blocking was found. The results suggest that neuromuscular function is normal in FHM.
Terwindt
G M
GM
Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands. G.M.Terwindt@lumc.nl
Kors
E E
EE
Vein
A A
AA
Ferrari
M D
MD
van Dijk
J G
JG
D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution; D015220:Calcium Channels / Q000235:genetics; D004576:Electromyography / Q000379:methods*; D005138:Eyebrows; D005260:Female; D006429:Hemiplegia / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D020125:Mutation, Missense; D017354:Point Mutation; D016037:Single-Blind Method; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics; D020864:Calcium Channels, N-Type
D015220:Calcium Channels; D000254:Sodium-Potassium-Exchanging ATPase; C105656:CACNA1A protein, human; D020864:Calcium Channels, N-Type; C498531:ATP1A2 protein, human