Anti-coxsackievirus B3 activity of 2-amino-3-nitropyrazolo[1,5-a]pyrimidines and their analogs.
A novel class of 2-amino-4-nitropyrazolo[1,5-a]pyrimidines has been identified as potent inhibitors of coxsackievirus B3 replication. The synthesis of these compounds is based on the regioselective reaction of 3,5-diamino-5-nitropyrazole with unsymmetrical beta-diketones at catalysis by hydrochloric acid leading to 2-amino-4-nitropyrazolo[1,5-a]pyrimidines as key steps.
Makarov
Vadim A
VA
Department of Medicinal Chemistry, Research Center for Antibiotics, 3a Nagatinskaya str., Moscow 117105, Russia.
Riabova
Olga B
OB
Granik
Vladimir G
VG
Dahse
Hans-Martin
HM
Stelzner
Axel
A
Wutzler
Peter
P
Schmidtke
Michaela
M
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D002460:Cell Line; D029822:Enterovirus B, Human / Q000187:drug effects*; D006801:Humans; D051379:Mice; D011720:Pyrazoles / Q000737:chemistry*; D011743:Pyrimidines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D011720:Pyrazoles; D011743:Pyrimidines