title: In vivo quantification of T1rho using a multislice spin-lock pulse sequence.
abstract: A multislice spin-lock (MS-SL) pulse sequence is implemented on a clinical scanner to acquire multiple images with spin-lock-generated contrast of the knee joints of six healthy human subjects. The MS-SL sequence produces images with T1rho contrast with an additional factor of intrinsic T2rho weighting, which hinders direct measurement of T1rho. A method is presented to compensate the MS-SL-generated data with regard to T2rho in an effort to accurately calculate multislice T1rho maps in a feasible experimental time. The T2rho-compensated multislice T1rho maps produced errors in the measurement of T1rho in healthy patellar cartilage of approximately 5% compared to the gold standard measurement of T1rho acquired with single-slice spin-lock pulse sequence. The MS-SL sequence has potential as an important clinical tool for the acquisition of multislice T1rho-weighted images and/or quantitative multislice T1rho maps.
authors.affiliation: Department of Radiology, University of Pennsylvania, Philadelphia 19104-6100, USA. wheaton@seas.upenn.edu
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Wheaton
authors.forename: Arijitt
authors.initials: A
authors.lastname: Borthakur
authors.forename: J Bruce
authors.initials: JB
authors.lastname: Kneeland
authors.forename: Ravinder R
authors.initials: RR
authors.lastname: Regatte
authors.forename: Sarma V S
authors.initials: SV
authors.lastname: Akella
authors.forename: Ravinder
authors.initials: R
authors.lastname: Reddy
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007719:Knee Joint / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male