title: Molecular characterization of HIV type 1 isolates from untreated patients of Mumbai (Bombay), India, and detection of rare resistance mutations.
abstract: The molecular characterization of HIV-1 isolates in drug-naive cases in the early stages of HIV disease was studied in 128 cases from Mumbai (Bombay), India. Subtype C was largely predominant followed by A-C intersubtype recombinants, one subtype A and one CRF01 AE. Compared to subtype B, subtype C exhibited an important polymorphism; the percentages of substitutions could reach more than 90%. Two isolates showed M184V substitution the reverse transcriptase indicating resistance to 3TC.
authors.affiliation: Grant Medical College and Sir JJ Hospital, Byculla, Mumbai, India.
authors.forename: Alaka
authors.initials: A
authors.lastname: Deshpande
authors.forename: Patricia
authors.initials: P
authors.lastname: Recordon-Pinson
authors.forename: Ranjana
authors.initials: R
authors.lastname: Deshmukh
authors.forename: Muriel
authors.initials: M
authors.lastname: Faure
authors.forename: Valérie
authors.initials: V
authors.lastname: Jauvin
authors.forename: Isabelle
authors.initials: I
authors.lastname: Garrigue
authors.forename: Marie-Edith
authors.initials: ME
authors.lastname: Lafon
authors.forename: Hervé J
authors.initials: HJ
authors.lastname: Fleury
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000145:classification* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007194:India; D008969:Molecular Sequence Data; D009154:Mutation; D017422:Sequence Analysis, DNA
chemical_list: D019380:Anti-HIV Agents; D054303:HIV Reverse Transcriptase; D016333:HIV Protease