DFNB44, a novel autosomal recessive non-syndromic hearing impairment locus, maps to chromosome 7p14.1-q11.22.
The genetic etiology for many forms of hearing impairment (HI) is very diverse. Non-syndromic HI (NSHI) is one of the most heterogeneous traits known. Autosomal recessive forms of prelingual HI account for approximately 75% of hereditary cases. A novel autosomal recessive NSHI locus, DFNB44, was mapped to a 20.9 cM genetic interval on chromosome 7p14.1-q11.22, according to the Marshfield genetic map, in a consanguineous Pakistani family. Multipoint linkage analysis resulted in a maximum LOD score of 5.0 at marker D7S1818. The 3-unit support interval ranged from marker D7S2209 to marker D7S2435, spanning a 30.1 Mb region on the sequence-based physical map.
Ansar
Muhammad
M
Department of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan.
Chahrour
Maria H
MH
Amin Ud Din
Mohammad
M
Arshad
Muhammad
M
Haque
Sayedul
S
Pham
Thanh L
TL
Yan
Kai
K
Ahmad
Wasim
W
Leal
Suzanne M
SM
D002897:Chromosomes, Human, Pair 7; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D034381:Hearing Loss / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree