Second-generation dimeric inhibitors of chitin synthase.
Chitin synthase (CS) is essential for fungal cell wall biosynthesis and is an attractive medicinal target. Expanded results from our efforts to develop mechanism based inhibitors of CS are presented here. Specifically, we describe uridine dimers linked by tartrate amides as potential pyrophosphate mimics.
Yeager
Adam R
AR
University of California, San Diego, Department of Chemistry and Biochemistry, 9500 Gilman Dr., La Jolla, CA 92093-0358, USA.
Finney
Nathaniel S
NS
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002687:Chitin Synthase / Q000037:antagonists & inhibitors*; D003432:Cross-Linking Reagents; D019281:Dimerization; D004791:Enzyme Inhibitors / Q000737:chemistry; D013329:Structure-Activity Relationship; D013644:Tartrates; D014529:Uridine
D000935:Antifungal Agents; D003432:Cross-Linking Reagents; D004791:Enzyme Inhibitors; D013644:Tartrates; D002687:Chitin Synthase; C029768:tartaric acid; D014529:Uridine