Effects of zolpidem and zopiclone on cognitive and attentional function in young healthy volunteers: an event-related potential study.
The effects of zolpidem and zopiclone, non-benzodiazepine ultra-short-acting hypnotics, on cognitive function and vigilance level were investigated in the morning following nocturnal administration using event-related potentials (ERP) and a sleep latency test (SLT). Zopiclone significantly shortened the sleep latency the following morning, whereas zolpidem did not, perhaps due to the difference in the elimination half-lives between the compounds. No significant effect was observed for either drug on the ERP indices, including the P3, mismatch negativity and negative difference components. At a clinically prescribed dosage these sleep inducers have no remarkable effect on cognitive or attentional functions but increase sleepiness of the subjects.
Nakajima
T
T
Department of Psychiatry, School of Medicine, Teikyo University Mizonokuchi Hospital, Kanagawa, Japan.
Takazawa
S
S
Hayashida
S
S
Nakagome
K
K
Sasaki
T
T
Kanno
O
O
D000328:Adult; D001288:Attention / Q000187:drug effects*; D053961:Azabicyclo Compounds; D003071:Cognition / Q000187:drug effects*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D018913:Event-Related Potentials, P300 / Q000187:drug effects; D005260:Female; D006207:Half-Life; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D010919:Placebos; D011725:Pyridines / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000077334:Zolpidem
D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; D010919:Placebos; D011725:Pyridines; C515050:zopiclone; D000077334:Zolpidem