title: Mycobactericidal and tuberculocidal activity of Korsolex AF, an amine detergent/disinfectant product.
abstract: The mycobactericidal and tuberculocidal activities of Korsolex AF against Mycobacterium tuberculosis, Mycobacterium avium-Mycobacterium intracellulare (MAI), Mycobacterium kansasii and Mycobacterium chelonae were determined using quantitative suspension and carrier tests. The effects of organic load and hard water were also considered. A clinical isolate of MAI was the most resistant of the four test organisms. A 2% solution had good mycobactericidal and tuberculocidal activities after 30 min of exposure. Although further evaluation using European standard tests is necessary, we conclude that Korsolex AF appears to be a promising product for the disinfection of hospital instruments contaminated with mycobacteria.
authors.affiliation: Servicio de Microbiología, Hospital Universitario Germans Trias i Pujol, Departamento de Genética y Microbiología, Facultad de Medicina, Universidad Autónoma de Barcelona, 08916 Badalona, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Hernández
authors.forename: E
authors.initials: E
authors.lastname: Martró
authors.forename: L
authors.initials: L
authors.lastname: Matas
authors.forename: A
authors.initials: A
authors.lastname: Jiménez
authors.forename: V
authors.initials: V
authors.lastname: Ausina
mesh_terms: D000588:Amines / Q000737:chemistry / Q000592:standards*; D002099:Cacao; D000074263:Coconut Oil; D015169:Colony Count, Microbial; D003902:Detergents / Q000737:chemistry / Q000592:standards*; D003959:Diamines / Q000737:chemistry / Q000592:standards*; D004202:Disinfectants / Q000737:chemistry / Q000592:standards*; D004203:Disinfection / Q000379:methods / Q000592:standards; D004353:Drug Evaluation, Preclinical; D024881:Drug Resistance, Bacterial; D004866:Equipment Contamination / Q000517:prevention & control*; D005060:Europe; D006801:Humans; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D015269:Mycobacterium avium Complex / Q000187:drug effects; D016926:Mycobacterium chelonae / Q000187:drug effects; D019909:Mycobacterium kansasii / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010938:Plant Oils / Q000737:chemistry; D012996:Solutions; D013535:Suspensions; D013997:Time Factors
chemical_list: D000588:Amines; D003902:Detergents; D003959:Diamines; D004202:Disinfectants; C498336:Korsolex AF; D010938:Plant Oils; D012996:Solutions; D013535:Suspensions; C034233:laurylpropylenediamine; D000074263:Coconut Oil