Vessel size imaging using low intravascular contrast agent concentrations.
Vessel size index (VSI) measurements have been validated on rats bearing a glioma with high doses of contrast agent. The aim of this study was to evaluate the impact of using a reduced dose of contrast agent, necessary for clinical trials. Experiments were performed on rats at three doses of AMI-227 and clearly show higher VSI values at lower doses, whatever the region of interest (contralateral, peritumoral and intratumoral tissue). These results are in good correlation with Monte-Carlo simulations on healthy brain and suggest that only relative values can be obtained at clinical contrast agent doses and magnetic fields.
Troprès
I
I
IFR1, Unité IRM 3T, Centre Hospitalier Universitaire, 38043, Grenoble CEDEX 9, France. Irene.Tropres@ujf-grenoble.fr
Lamalle
L
L
Farion
R
R
Segebarth
C
C
Rémy
C
C
D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology*; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000008:administration & dosage; D003342:Corpus Striatum / Q000098:blood supply / Q000473:pathology; D003911:Dextrans; D004305:Dose-Response Relationship, Drug; D052203:Ferrosoferric Oxide; D005910:Glioma / Q000098:blood supply / Q000473:pathology; D007089:Image Enhancement / Q000379:methods; D007501:Iron / Q000008:administration & dosage*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D008833:Microcirculation / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010087:Oxides / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide