Intralesional interferon alfa-2b treatment of keratoacanthomas.
BACKGROUND
Complete excision is not always easy when a keratoacanthoma is large or located in certain anatomic areas. An effective nonsurgical treatment would be desirable in such cases.


OBJECTIVE
This was a pilot study of the effects of intralesional interferon alfa-2b in the treatment of rapidly growing keratoacanthomas.


METHODS
A total of 4 large, rapidly growing keratoacanthomas, which were located on the lower lip, neck, and cheeks of the 4 different patients, were treated with intralesional interferon alfa-2b injection weekly. Serial photographs were taken to observe the course of responses.


RESULTS
All lesions resolved completely in 5 to 7 weeks with acceptable cosmetic results.


CONCLUSIONS
Intralesional interferon alfa-2b can be a treatment modality of these difficult lesions.
Oh
Chang-Keun
CK
Department of Dermatology, Pusan National University College of Medicine, Busan, Korea. ckoh@pusan.ac.kr
Son
Hyo-Sung
HS
Lee
Jae-Bong
JB
Jang
Ho-Sun
HS
Kwon
Kyung-Sool
KS
D000368:Aged; D002610:Cheek; D023341:Chills / Q000139:chemically induced; D005260:Female; D005334:Fever / Q000139:chemically induced; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional / Q000009:adverse effects; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000009:adverse effects; D007636:Keratoacanthoma / Q000188:drug therapy*; D008047:Lip Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009333:Neck; D010146:Pain / Q000209:etiology; D010865:Pilot Projects; D011994:Recombinant Proteins
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins