Misfolded proteins and human diseases.
Though protein folding is a regular phenomenon inside the cellular milieu, slight differences in the folding pattern of proteins may lead to disease-causing forms. Many diseases have been identified that are caused by these misfolded macromolecules and a considerable amount of focus is still directed towards better understanding of the processes that lead to these misfolded structures. Further progress in the field of how soluble proteins begin to misfold and how resultant oligomers begin dysfunction offers exciting prospects for specific molecular intervention.
Nayeem
M S
MS
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.
Khan
Rizwan H
RH
D000682:Amyloid / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D000686:Amyloidosis / Q000378:metabolism*; D006801:Humans; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity
D000682:Amyloid; D011506:Proteins