title: Common genetic basis between type 1 and type 2 diabetes mellitus indicated by interview-based assessment of family history.
abstract: To investigate the intrafamilial clustering of type 1 and type 2 diabetes, an interview-based assessment of family history of diabetes was conducted. Outpatients with either type 1 (n = 23) or type 2 diabetes (n = 124), and non-diabetic subjects (n = 118) received an interview regarding the diabetic status of each of their family members. In patients with type 1 diabetes, 22% (5 out of 23) had a parental history of diabetes, and diabetes in these 5 parents was assessed as type 2 diabetes mellitus. The prevalence of parental diabetes in the type 1 diabetic probands (22%) was significantly higher (P < 0.05) than that in non-diabetic probands (7%, 8 out of 118). In probands with type 2 diabetes, the prevalence of parental diabetes was 39% (48 out of 124), which was significantly higher (P < 0.0005) than that in the non-diabetic probands (7%). In the type 2 diabetic probands, no significant difference was noted in the prevalence between paternal (19%, 23 out of 124) and maternal diabetes (23%, 28 out of 124), suggesting no preferential inheritance of maternal diabetes in this population. The present interview-based assessment of family history of diabetes suggested a common genetic basis between type 1 and type 2 diabetes.
authors.affiliation: Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikegami
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Koji
authors.initials: K
authors.lastname: Nojima
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kawabata
authors.forename: Masaya
authors.initials: M
authors.lastname: Ono
authors.forename: Masanori
authors.initials: M
authors.lastname: Nishino
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Noso
authors.forename: Hidenori
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Mayumi
authors.initials: M
authors.lastname: Horiki
authors.forename: Michiko
authors.initials: M
authors.lastname: Itoi-Babaya
authors.forename: Naru
authors.initials: N
authors.lastname: Babaya
authors.forename: Kaori
authors.initials: K
authors.lastname: Inoue
authors.forename: Toshio
authors.initials: T
authors.lastname: Ogihara
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005190:Family; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D007564:Japan / Q000453:epidemiology; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D009679:Nuclear Family; D015995:Prevalence; D012016:Reference Values