Evaluation of a hydrogen laser vacuum ultraviolet source for photoionization mass spectrometry of pharmaceuticals.
A photoionization hydrogen laser time-of-flight mass spectrometer system (H2-TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H2-TOFMS showed primarily intact molecular ions (M+*) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid-phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents.
Finch
Jeffrey W
JW
Waters Corp., 34 Maple Street, Milford, MA 01757, USA.
Toerne
Kevin A
KA
Schram
Karl H
KH
Denton
M Bonner
MB
D000082:Acetaminophen / Q000652:urine*; D006801:Humans; D007834:Lasers; D013058:Mass Spectrometry / Q000379:methods; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D019966:Substance-Related Disorders
D004364:Pharmaceutical Preparations; D000082:Acetaminophen