title: Perforation of the terminal ileum: a possible complication of nicorandil therapy.
abstract: Recent reports have implicated nicorandil as a possible causative agent in the pathogenesis of anal and oral ulceration. We report a case of ulceration and perforation of the terminal ileum in a patient taking nicorandil. The possibility of an association between nicorandil therapy and gastrointestinal ulceration is discussed.
authors.affiliation: Department of Surgery, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, AB25 2ZN, UK. P.M.King@arh.grampian.scot.nhs.uk
authors.forename: P M
authors.initials: PM
authors.lastname: King
authors.forename: S A
authors.initials: SA
authors.lastname: Suttie
authors.forename: J O
authors.initials: JO
authors.lastname: Jansen
authors.forename: A J M
authors.initials: AJ
authors.lastname: Watson
mesh_terms: D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007077:Ileal Diseases / Q000473:pathology; D007416:Intestinal Perforation / Q000139:chemically induced* / Q000601:surgery*; D007813:Laparotomy / Q000379:methods; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000188:drug therapy*; D020108:Nicorandil / Q000009:adverse effects* / Q000627:therapeutic use; D018570:Risk Assessment; D016896:Treatment Outcome; D014456:Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery
chemical_list: D020108:Nicorandil