Family history of primary movement disorders as a predictor for neuroleptic-induced extrapyramidal symptoms.
BACKGROUND
A genetic susceptibility to extrapyramidal symptoms caused by treatment with neuroleptic medication has been suggested.


OBJECTIVE
To identify predictor variables for neuroleptic-induced extrapyramidal symptoms, particularly considering family history of primary movement disorders.


METHODS
We investigated 100 in-patients receiving a stable neuroleptic medication with regard to occurrence of extrapyramidal symptoms, drug history and detailed family history of primary movement disorders.


RESULTS
Step-wise logistic regression analysis revealed that a positive family history was a significant predictor for lifetime prevalence of extrapyramidal symptoms, including reported and currently observed symptoms. The duration of exposure to neuroleptic medication and age were further predictors.


CONCLUSIONS
Our findings underline the notion of genetic susceptibility for secondary extrapyramidal symptoms and suggest possible shared genetic factors in primary and secondary movement disorders as well as psychotic disorders.
Lencer
Rebekka
R
Department of Psychiatry and Psychotherapy, University of Lübeck, Germany. lencer.r@psychiatry.uni-luebeck.de
Eismann
Gunnar
G
Kasten
Meike
M
Kabakci
Kemal
K
Geithe
Verena
V
Grimm
Jenny
J
Klein
Christine
C
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000235:genetics*; D010375:Pedigree; D015995:Prevalence; D012559:Schizophrenia / Q000188:drug therapy
D014150:Antipsychotic Agents