Acellular pertussis vaccines and complement killing of Bordetella pertussis.
Antibody-dependent complement killing of Bordetella pertussis after immunization with a three-component acellular pertussis vaccine was characterized. Postimmunization activity was unchanged for about half of the adult vaccine recipients. The responses of the other individuals were complex, with evidence of both beneficial and antagonistic responses occurring, sometimes in the same individual.
Weiss
Alison A
AA
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267-0524, USA. Alison.Weiss@uc.edu
Patton
Angela K
AK
Millen
Scott H
SH
Chang
Swei-Ju
SJ
Ward
Joel I
JI
Bernstein
David I
DI
D000907:Antibodies, Bacterial / Q000097:blood; D001770:Blood Bactericidal Activity; D001886:Bordetella pertussis / Q000276:immunology*; D003165:Complement System Proteins / Q000502:physiology*; D004311:Double-Blind Method; D006801:Humans; D007114:Immunization; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D010567:Pertussis Vaccine / Q000276:immunology*; D011446:Prospective Studies; D022282:Vaccines, Acellular / Q000276:immunology
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D010567:Pertussis Vaccine; D022282:Vaccines, Acellular; D003165:Complement System Proteins