Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy.
Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue swelling occurred in a patient during antiretroviral treatment, despite an increased CD4(+) lymphocyte count and decreased HIV-1 level and KS-associated herpesvirus replication, suggesting immune reconstitution inflammatory syndrome. Inflammation resolved coincident with decreases in the CD4(+) lymphocyte count during paclitaxel treatment, whereas KS cleared only after prolonged antiretroviral therapy and chemotherapy.
Connick
Elizabeth
E
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA. liz.connick@uchsc.edu
Kane
Madeleine A
MA
White
Irene E
IE
Ryder
John
J
Campbell
Thomas B
TB
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1 / Q000276:immunology / Q000502:physiology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007154:Immune System Diseases / Q000097:blood / Q000209:etiology* / Q000276:immunology; D007249:Inflammation; D008297:Male; D017239:Paclitaxel / Q000627:therapeutic use; D012514:Sarcoma, Kaposi / Q000097:blood / Q000209:etiology* / Q000276:immunology / Q000821:virology; D013577:Syndrome; D019562:Viral Load
D004279:DNA, Viral; D017239:Paclitaxel