[Experimental study on guiding bone regeneration with bovine pericardium membrane].
OBJECTIVE
To explore the feasibility of bovine pericardium used as a material for guiding bone regeneration.


METHODS
1 cm x 1 cm x 0.5 cm defects were created on both buccal sides of the mandibles of 11 dogs. One side was covered with Glutaraldehyde (GA) cross-linking bovine pericardium; no membrane covered side was used as control. The animals were sacrificed in 2 weeks, 4 weeks, 8 weeks and 16 weeks after operation to observe the repair of the bone defects.


RESULTS
(1) Wounds healed well in 10 dogs. Meanwhile, wounds in dogs of 16 weeks group healed badly and severe inflammatory response was found in bovine pericardium treated area. (2) The pericardium can be maintained in vivo for 16 weeks without absorption, there were only mild inflammatory cells invading. (3) The bone defects covered with bovine pericardium repaired better than control groups significantly.


CONCLUSIONS
(1) GA bovine pericardium have the effect on guiding bone regeneration in the repair of dog experimental bone defects and it is possible that the bovine pericardium will be used as a new kind of GBR material; (2) GA bovine pericardium has good biocompatibility.
Zhou
Yi-qun
YQ
Dept. of Stomatology, The Second Hospital of Xiangya Medical College, Central South University, Changsha 410011, China.
Wu
Han-jiang
HJ
D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration / Q000502:physiology*; D002417:Cattle; D004285:Dogs; D005240:Feasibility Studies; D008297:Male; D008338:Mandibular Injuries / Q000601:surgery*; D010496:Pericardium / Q000502:physiology*
D001672:Biocompatible Materials