title: A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells.
abstract: Modified thymidine analogues have been highlighted as useful agents for the treatment of cancer and viral diseases due to their potent biological activities. In the present study, we synthesized a new thymidine analogue, 7-(3-bromo-phenoxy)-thymidine (4a), as a potential lead for anti-tumor agent. Compound 4a potently inhibits HeLa cell proliferation with an IC(50) of 15 microM.
authors.affiliation: Chemical Genomics National Research Laboratory, Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.
authors.forename: Kyung Noo
authors.initials: KN
authors.lastname: Kim
authors.forename: Jiyong
authors.initials: J
authors.lastname: Lee
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: Jong-Shin
authors.initials: JS
authors.lastname: Yoo
authors.forename: Ho Jeong
authors.initials: HJ
authors.lastname: Kwon
mesh_terms: D002455:Cell Division / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C500015:7-(3-bromo-phenoxy)-thymidine; D013936:Thymidine