[Effects of treatments on serum vitamin E levels in lung cancer].
Previous evidence suggests that malignant tumours cause an decrease in the serum vitamin E level. We followed the serum alpha tocopherol in 55 lung cancer patients. The objective of the study was to evaluate the effects of treatments of lung cancer on serum vitamin E evolution. The vitamin E of patients symptomatically treated decreases from the first month and this decrease is significant (p < 0.001) in patients affected by SCLC and in those with NSCLC classified stage III and IV. The reduction of the vitamin E is also noted in the patients treated with chemotherapy (p < 0.001). Vitamin E levels improve gradually to reach standard values in the patients who followed a curative radiotherapy or benefited from the surgical ablation of the tumour. At 4 months after the surgical removal of the tumour, there was an increase in serum vitamin E concentrations and reached the normal values. This data indicates that surgical removal of lung cancer increases serum vitamin E concentrations compared to the baseline values possibly reflecting the relief of oxidative stress caused by malignant tumours.
Trabelsi Alouane
Leïla
L
Ecole supérieure des sciences et techniques de la santé de Tunis, Université El Mannar, Département de nutrition, BP176, Bab Suika, 1006 Tunis, Tunisie.
Ghawar
Chekib
C
Tritar Cherif
Fatma
F
Belhabib
Dalenda
D
Maalej
Mohsen
M
D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000473:pathology / Q000628:therapy; D018288:Carcinoma, Small Cell / Q000097:blood / Q000473:pathology / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology / Q000628:therapy; D014810:Vitamin E / Q000097:blood*
D014810:Vitamin E