title: Co-occurrence of Wilson's disease and glioblastoma multiforme--is it a chance association?
abstract: We report a patient with glioblastoma multiforme who was subsequently diagnosed to have Wilson's disease. Immunohistochemical studies of the tumor revealed high (> 60%) labeling index for p53 and Rb retinoblastoma protein. Whether this association is like the co-occurrence of retinoblastoma and Wilson's disease due to possible somatic mutation in chromosome 13 needs to be explored.
authors.affiliation: Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: L K
authors.initials: LK
authors.lastname: Prashanth
authors.forename: A
authors.initials: A
authors.lastname: Mahadevan
authors.forename: S
authors.initials: S
authors.lastname: Satish
authors.forename: S
authors.initials: S
authors.lastname: Ravishankar
authors.forename: G R
authors.initials: GR
authors.lastname: Arunodaya
authors.forename: A B
authors.initials: AB
authors.lastname: Taly
authors.forename: S K
authors.initials: SK
authors.lastname: Shankar
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D005909:Glioblastoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006527:Hepatolenticular Degeneration / Q000150:complications*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D016160:Retinoblastoma Protein / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53