title: RNA expression analysis of a congenital intracranial teratoma.
abstract: Congenital intracranial tumors are extremely rare and account only for 0.5%-1.5% of brain tumors in children. We report a large intrauterine congenital teratoma in a female fetus at gestation weeks 37, which was diagnosed by detecting the tumor and associated craniomegaly with ultrasonography (US) and magnetic resonance (MR) imaging. The tumor had replaced the cerebral hemispheres and produced prenatal manifestations. Pathologic examination showed an immature teratoma, which was differentiated from all three germ layers. Microarray analysis revealed upregulation of ten genes and downregulation of three genes, as well as upregulation of 41 genes of ribosomal proteins in teratoma cells, compared to normal brain tissue of the patient. The data from the microarray analysis offer not only the potential to help define disease pathogenesis but may also provide clues to identify potential molecular therapeutic targets.
authors.affiliation: Department of Pediatrics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yokoi
authors.forename: Masaharu
authors.initials: M
authors.lastname: Akiyama
authors.forename: Takaaki
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: Masami
authors.initials: M
authors.lastname: Yoshino
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Nakazaki
authors.forename: Koichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Junko
authors.initials: J
authors.lastname: Takahashi-Fujigasaki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kanetsuna
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamada
authors.forename: Shizuo
authors.initials: S
authors.lastname: Oi
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Eto
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000151:congenital / Q000175:diagnosis* / Q000235:genetics; D003952:Diagnostic Imaging; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D005333:Fetus; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011247:Pregnancy; D012334:RNA, Neoplasm / Q000032:analysis; D013724:Teratoma / Q000151:congenital / Q000175:diagnosis* / Q000235:genetics
chemical_list: D012334:RNA, Neoplasm