Parallel supported synthesis of polyamine-imidazole conjugates.
[reaction: see text] A small collection of nine polyamine-imidazole conjugates, potentially acting as RNases A mimics, has been synthesized on SynPhase lanterns using amino alcohols and diamines as building blocks. Couplings were performed via S(N)2 alkylation of methanesulfonates with amines. The final introduction of N-4-nitrobenzyloxycarbonyldiamines allowed easy purification of the cleaved compounds.
Picard
Sylvie
S
Université Rennes 1, Institut de Chimie de Rennes, Synthèse et Extraction de Molécules à Visée Thérapeutique, Faculté des Sciences Biologiques et Médicales, 2 avenue du professeur Léon Bernard, 35043 Rennes, France.
Le Roch
Myriam
M
Renault
Jacques
J
Uriac
Philippe
P