title: Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy.
abstract: Twenty-six infants with hypoxic-ischemic encephalopathy (HIE) were randomized to normothermia or to systemic hypothermia. The hypothermia group had less cortical gray matter signal abnormality on magnetic resonance imaging (MRI) (1/12 vs 7/14 infants in the normothermic group; P = .036), which may indicate differing regional benefit from systemic hypothermia.
authors.affiliation: Division of Newborn Services, Royal Women's Hospital, Neonatal Neurology, Royal Children's Hospital, Melbourne, Australia. terrie.inder@rch.org.au
authors.forename: Terrie E
authors.initials: TE
authors.lastname: Inder
authors.forename: Rod W
authors.initials: RW
authors.lastname: Hunt
authors.forename: Colin J
authors.initials: CJ
authors.lastname: Morley
authors.forename: Lee
authors.initials: L
authors.lastname: Coleman
authors.forename: Michael
authors.initials: M
authors.lastname: Stewart
authors.forename: Lex W
authors.initials: LW
authors.lastname: Doyle
authors.forename: Susan E
authors.initials: SE
authors.lastname: Jacobs
mesh_terms: D004569:Electroencephalography; D005865:Gestational Age; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000628:therapy*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging