[Control of calcification by extracellular matrix].
Physiological calcification begins from crystallization of hydroxyapatite in extracellular matrix of both bones and teeth. Because calcification is exactly the extracellular event, organic components of extracellular matrix play important roles in control of calcification. The authors discuss the molecular regulation of calcification by organic components of extracellular matrix, focusing on the mineral/organic interaction.
Hoshi
Kazuto
K
Department of MENICON cartilage and Bone Regeneration, Graduate School of Medicine, The University of Tokyo.
Ozawa
Hidehiro
H
D015055:1-Carboxyglutamic Acid / Q000502:physiology; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002113:Calcification, Physiologic / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D003460:Crystallization; D017886:Durapatite / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D015675:Osteocalcin / Q000502:physiology; D015676:Osteonectin / Q000502:physiology; D053495:Osteopontin; D010743:Phospholipids / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D011509:Proteoglycans / Q000502:physiology; D012795:Sialoglycoproteins / Q000502:physiology; D014070:Tooth / Q000378:metabolism
D015676:Osteonectin; D010743:Phospholipids; D011509:Proteoglycans; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D015675:Osteocalcin; D053495:Osteopontin; D010758:Phosphorus; D015055:1-Carboxyglutamic Acid; D003094:Collagen; D017886:Durapatite; D002118:Calcium