Proinflammatory parameters as CRP and IL-6 do not discriminate between post-PCI cardiac patients with and without exercise-induced ischemia as indicated by Tl-201 myocardial scintigraphy.
BACKGROUND
Atherosclerosis is looked upon as an inflammatory disease. The production of proinflammatory markers may indicate activity in this inflammatory state.


METHODS
We prospectively evaluated a range of proinflammatory serum parameters in 136 cardiac patients who had previously undergone percutaneous coronary intervention (PCI).


RESULTS
By means of myocardial scintigraphy, an ischemia group (A; n=49) and a group with stable cardiovascular disease without exercise induced ischemia (B; n=87) were distinguished. Risk factors and lipoprotein profile of both groups were comparable. Serum levels of serum C-reactive protein (CRP), IL-6, sTNF-RI, IGF-I, neopterin, serotonin and prolactin did not present any significant difference between the two groups.


CONCLUSIONS
We conclude that measurement of these (inflammatory) parameters does not help to delineate post-PCI cardiac patients with and without exercise-induced ischemia.
Pichler
Robert
R
Institute of Nuclear Medicine and Endocrinology, General Hospital Linz, Linz, Austria. robert.pichler@gespag.at
Berg
Jörg
J
Maschek
Wilhelmine
W
Schimetta
Wolfgang
W
Steinwender
Clemens
C
Hofmann
Robert
R
Leisch
Franz
F
D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein / Q000032:analysis*; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012307:Risk Factors; D013794:Thallium Radioisotopes
D015850:Interleukin-6; D013794:Thallium Radioisotopes; D002097:C-Reactive Protein