Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology.
Tremorine-induced tremors model is used to evaluate antiparkinsonian drugs because rest tremor is a sign that distinguishes Parkinson's disease (PD) from other diseases. The effects of crude ethanolic extract (CEE) and total acetate fraction (TAF) of Plumbago scandens were investigated at several doses. These extracts at doses of 125 and 250 mg/kg i.p. failed to reduce tremors in tremorine-treated mice. TAF showed significant effects only at a dose of 500 mg/kg. Both CEE and TAF at doses of 1000 and 2000 mg/kg i.p. suppressed the tremors in a dose-dependent fashion for 60 min. Biperiden, an anticholinergic drug, was used as standard at a dose of 3 mg/kg i.p. This study suggests that P. scandens is a plant with possible therapeutic value for PD.
Morais
L C S L
LC
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, CP 5009, CEP 58051-970 João Pessoa, PB, Brazil. liana@ltf.ufpb.br
Quintans-Júnior
L J
LJ
Franco
C I F
CI
Almeida
J R G S
JR
Almeida
R N
RN
D000818:Animals; D000978:Antiparkinson Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D018514:Plant Structures; D029606:Plumbaginaceae; D014202:Tremor / Q000139:chemically induced / Q000188:drug therapy*; D014203:Tremorine / Q000633:toxicity*
D000978:Antiparkinson Agents; D010936:Plant Extracts; D014203:Tremorine