title: Gamma-lactone-tethered ring-closing metathesis. A route to enantiomerically enriched gamma-lactones alpha,beta-fused to medium-sized rings.
abstract: [reaction: see text] The stereoselective alkylation of alpha-(phenylsulfonyl)-beta-[(methoxycarbonyl)methyl]-gamma-lactones obtained by the base-induced cyclization of enantiomerically enriched alpha-[(phenylthio)acyl]-alpha,beta-unsaturated esters and ring-closing olefin metathesis (RCM) are the basis of a new approach for gaining access to gamma-lactones that are alpha,beta-fused to medium-sized carbocycles and cyclic ethers.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, C/Astrofísico Francisco Sánchez, 2, 38206 La Laguna, Tenerife, Spain.
authors.forename: Carmen M
authors.initials: CM
authors.lastname: Rodríguez
authors.forename: José Luis
authors.initials: JL
authors.lastname: Ravelo
authors.forename: Víctor S
authors.initials: VS
authors.lastname: Martín