Aminophylline as an adjunct diuretic for neonates--a case series.
Aminophylline is an adenosine receptor antagonist. Adult and paediatric studies have demonstrated a diuretic effect of aminophylline due to increased renal blood flow and the inhibition of solute reabsorption in various segments of the nephron. We report a case series of five infants with volume overload despite frusemide treatment. Aminophylline was successfully used as an adjunct diuretic with increased urine output and effective weight loss occurring in all five neonates following its introduction.
Ng
Geraldine Yin Taeng
GY
Department of Neonatology, Neonatal Intensive Care Unit, St George's Hospital, Blackshaw Road, Tooting, London SW17 0RE, UK. drgytng@aol.com
Baker
Emma Harriet
EH
Farrer
Katharine Florence Mary
KF
D000628:Aminophylline / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012189:Retrospective Studies; D014883:Water-Electrolyte Imbalance / Q000188:drug therapy*
D004232:Diuretics; D000628:Aminophylline