title: Prevalence of human papillomavirus in Mazandaran Province, Islamic Republic of Iran.
abstract: We report the prevalence of human papillomavirus (HPV) types in 100 cervical biopsy specimens in Mazandaran province. HPV DNA was detected in 78.6% of cervical carcinoma cases, 64.3% of dys/ metaplasia and 9% of normal cases. Significant correlation was found between the presence of HPV DNA and development of cervical carcinoma. HPV types 16 and 18 were detected in 60.6% of HPV-positive cervical carcinoma cases, whereas HPV31 and 33 were found in 21.2%, and HPV6 and 11 in 18.2%. Among HPV-positive dys/metaplasia cases, 55.6% were positive for HPV16 and 18, 22.3% for HPV6 and 11, and 11.1% for HPV31 and 33. Only HPV6 and 11 were detected in 4 (100%) normal biopsy specimens.
authors.affiliation: Division of Virology, Department of Pathobiology, School of Public Health, Institute of Public Health Research, Teheran University of Medical Sciences, Teheran, Islamic Republic of Iran.
authors.forename: R
authors.initials: R
authors.lastname: Hamkar
authors.forename: T Mokhtari
authors.initials: TM
authors.lastname: Azad
authors.forename: M
authors.initials: M
authors.lastname: Mahmoodi
authors.forename: S
authors.initials: S
authors.lastname: Seyedirashti
authors.forename: A
authors.initials: A
authors.lastname: Severini
authors.forename: R
authors.initials: R
authors.lastname: Nategh
mesh_terms: D001706:Biopsy; D016022:Case-Control Studies; D003043:Cocarcinogenesis; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D007492:Iran / Q000453:epidemiology; D017720:Molecular Epidemiology; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction / Q000379:methods; D011159:Population Surveillance; D015995:Prevalence; D013997:Time Factors; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*
chemical_list: D004279:DNA, Viral