title: Self-navigated interleaved spiral (SNAILS): application to high-resolution diffusion tensor imaging.
abstract: A fat-saturated twice-refocused spin echo sequence was implemented on a GE Signa 1.5-T whole-body system for diffusion-weighted imaging. Data were acquired using an analytically designed interleaved variable-density (VD) spiral readout trajectory. This flexible design algorithm allowed real-time prescription on the scanner. Each interleaf of the VD spiral oversampled the center of k-space. The oversampling provided an inherent motion compensation capability. The resultant diffusion-weighted images showed good quality without any retrospective motion correction. An iterated motion correction algorithm was developed to further reduce the signal cancellation artifact caused by motion-induced phase error. In this algorithm, a low-resolution phase map was estimated using the oversampled data in the center of k-space in order to correct for phase error in image space. In vivo diffusion tensor imaging (DTI) studies were performed on the brains of healthy volunteers. High-quality isotropic diffusion-weighted images, trace maps, and FA maps from axial, sagittal, and coronal slices were obtained using a VD spiral readout trajectory with matrix size 256 x 256. To our knowledge, this was also the first time in vivo 512 x 512 DTI results were reported.
authors.affiliation: Lucas MRS/I Center, Department of Radiology, Stanford University, California 94305-5488, USA.
authors.forename: Chunlei
authors.initials: C
authors.lastname: Liu
authors.forename: Roland
authors.initials: R
authors.lastname: Bammer
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Michael E
authors.initials: ME
authors.lastname: Moseley
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009038:Motion