[Nucleotide-dependent degradation of nucleic acids by DNA and RNA polymerases].
In this review we summarize the current knowledge about recently discovered reactions of nucleotide-dependent nucleic acid degradation catalyzed by DNA and RNA polymerases. These reactions consist in the excision of the 3'-nucleotide of nascent DNA or RNA chain in the presence of non-complementary r/dNTPs. In the case of DNA polymerases the dinucleoside-5',5"-tetraphosphate as a product of the reaction is formed. In contrast, in the case of RNA polymerases non-complementary r/dNTPs stimulate 3'-->5' exonuclease degradation of RNA transcript. The possible role of these reactions in fidelity of DNA and RNA synthesis, in resistance of HIV reverse transcriptase towards nucleoside inhibitors is discussed.
Sosunov
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Viktorova
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D002384:Catalysis; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000502:physiology*; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000502:physiology*; D024882:Drug Resistance, Viral / Q000235:genetics / Q000502:physiology; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000502:physiology; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D006801:Humans; D009711:Nucleotides / Q000378:metabolism*; D012313:RNA / Q000737:chemistry / Q000378:metabolism*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology
D009711:Nucleotides; D018894:Reverse Transcriptase Inhibitors; D012313:RNA; D004247:DNA; D054303:HIV Reverse Transcriptase; D012321:DNA-Directed RNA Polymerases; D004259:DNA-Directed DNA Polymerase