Liver transplant: adenosine metabolism and apoptosis.
Apoptosis and necrosis coexist in ischemia-reperfusion (I/R) injury following organ transplant. During experimental liver transplant we evidenced a deep alteration in energy and antioxidant status. The activity of purine catabolic enzymes was also altered. Caspase-3 (C-3), protein tyrosine phosphatase (PTP) showed significative alterations that lead to DNA fragmentation. These findings could be of interest in new potential strategy to prevent and treat I/R injury.
Carlucci
F
F
Dipartimento di Medicina Interna, Sci. Endocrino-Metaboliche e Biochimica, Università di Siena, Italy.
Marinello
E
E
Gerunda
G
G
Neri
D
D
Rosi
F
F
Floccari
F
F
Tabucchi
A
A
D000241:Adenosine / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis; D001706:Biopsy; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D053938:DNA Fragmentation; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation; D009336:Necrosis; D010455:Peptides / Q000737:chemistry; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011687:Purines / Q000737:chemistry; D015427:Reperfusion Injury; D013552:Swine
D000975:Antioxidants; D010455:Peptides; D011687:Purines; D000255:Adenosine Triphosphate; D004247:DNA; D017027:Protein Tyrosine Phosphatases; D053148:Caspase 3; D020169:Caspases; D005978:Glutathione; D000241:Adenosine