title: Novel intramolecular rearrangement leading to the synthesis of biheterocyclic indole-benzoimidazole derivatives on solid phase.
abstract: [reaction: see text] A novel intramolecular SNAr rearrangement observed during the S-alkylation of benzoimidazole-2-thione with alpha-haloacetophenone is reported. The rearrangement led to the formation of a new benzoimidazole-based intermediate, which is further utilized for the generation of a new biheterocyclic indole-benzimidazole derivatives with a two-point diversity.
authors.affiliation: Division of SAIF, Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Abhijeet Deb
authors.initials: AD
authors.lastname: Roy
authors.forename: Sunil
authors.initials: S
authors.lastname: Sharma
authors.forename: Rajesh Kumar
authors.initials: RK
authors.lastname: Grover
authors.forename: Bijoy
authors.initials: B
authors.lastname: Kundu
authors.forename: Raja
authors.initials: R
authors.lastname: Roy