[Synthesis from tigogenin and antituberculosis activity of some of the derivatives of 5alpha-ketosteroid hydrazones].
Isonicotinoylhydrazones and thiosemicarbazones of some 5alpha-ketosteroids were synthesized from tigogenin, and their structures were confirmed by NMR and IR spectroscopy and mass spectrometry. Their antimycobacterial activities were studied, and it was shown that some of the synthesized isonicotinoylhydrazones exhibit a high antituberculosis activity. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // www.maik.ru.
Merlani
M I
MI
Kemertelidze
E P
EP
Popandopoulos
K
K
Men'shova
N I
NI
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry*; D007664:Ketosteroids / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects; D013150:Spirostans / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000995:Antitubercular Agents; D006835:Hydrazones; D007664:Ketosteroids; D013150:Spirostans; C046297:sarsasapogenin