A new ene-triyne antibiotic from the fungus Baeospora myosura.
The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active against Gram-negative bacteria and a yeast. MICs against several strains of Staphylococcus aureus were as low as 0.001 microg/mL. Analogues of 1 that did not contain the ene-triyne moiety were inactive against all microorganisms tested. The isolation of this new natural product was complicated by the highly reactive nature of the conjugated terminal polyacetylene.
Parish
Craig A
CA
Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065-0900, USA. craig_parish@merck.com
Huber
Joann
J
Baxter
Jenny
J
González
Antonio
A
Collado
Javier
J
Platas
Gonzalo
G
Diez
Maria Teresa
MT
Vicente
Francisca
F
Dorso
Karen
K
Abruzzo
George
G
Wilson
Kenneth
K
D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053279:Polyynes; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D011108:Polymers; D053279:Polyynes; D000114:Acetylene