Stability of two new anticonvulsants in body fluids and tissues.
Stability of two compounds with established anticonvulsant activity, picolinic acid benzylamide (Pic-BZA) and nicotinic acid benzylamide (Nic-BZA), incubated in homogenates of body organs and in body fluids was determined at different time points. Pic-BZA was found to decompose fairly rapidly in the liver and the kidney, while Nic-BZA demonstrated stability against enzymes present in these organs and fluids.
Goldnik
Anna
A
Department of Drug Chemistry, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
Marszałek
Dorota
D
Paruszewski
Ryszard
R
Stables
James P
JP
D000818:Animals; D000927:Anticonvulsants / Q000302:isolation & purification / Q000493:pharmacokinetics* / Q000494:pharmacology; D001593:Benzyl Compounds / Q000302:isolation & purification / Q000493:pharmacokinetics* / Q000494:pharmacology; D001826:Body Fluids / Q000737:chemistry / Q000378:metabolism*; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007668:Kidney / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009525:Niacin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000493:pharmacokinetics* / Q000494:pharmacology; D010848:Picolinic Acids / Q000302:isolation & purification / Q000493:pharmacokinetics* / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D000927:Anticonvulsants; D001593:Benzyl Compounds; D010848:Picolinic Acids; C484800:nicotinic acid benzylamide; C484799:picolinic acid benzylamide; D009525:Niacin