[Regulation of bone mineralization by parathyroid hormone].
In randomized clinical trials, parathyroid hormone (PTH) showed potent anabolic effects on the lumbar spine and decreased the risk of incident vertebral fractures dramatically. Although the anabolic effect of PTH on cortical bone in the femoral neck is still unclear, it should be demonstrated in further clinical studies. Concurrent or sequential therapies of PTH and anti-resorptive agents will be one of the major issues of treatment for osteoporosis in the future.
Shimizu
Masaru
M
Pharmaceutical Research Department II, Chugai Pharmaceutical Co., Ltd.
Tamura
Tatsuya
T
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism; D002113:Calcification, Physiologic / Q000187:drug effects; D002116:Calcitonin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006023:Glycoproteins / Q000008:administration & dosage; D006801:Humans; D008159:Lumbar Vertebrae; D015675:Osteocalcin / Q000008:administration & dosage; D010024:Osteoporosis / Q000188:drug therapy / Q000517:prevention & control; D053244:Osteoprotegerin; D010281:Parathyroid Hormone / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D044162:Parathyroid Hormone-Related Protein / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic; D018160:Receptors, Cytoplasmic and Nuclear / Q000008:administration & dosage; D018124:Receptors, Tumor Necrosis Factor; D016103:Spinal Fractures / Q000517:prevention & control; D013268:Stimulation, Chemical; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives*
D006023:Glycoproteins; D053244:Osteoprotegerin; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; C506030:TNFRSF11B protein, human; D015675:Osteocalcin; D013739:Testosterone; D002116:Calcitonin; C016131:testosterone 17 beta-cypionate