title: Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based study.
abstract: OBJECTIVE
  Quality of life (QOL) has become an important outcome measure for patients with cancer, but long-term results from population-based studies are rare. The objective of our study was to identify specific limitations of QOL in survivors of colorectal cancer in comparison with men and women from the general population 1 year after diagnosis when acute treatment effects are expected to have declined.
  
  
  METHODS
  QOL was assessed 1 year after diagnosis in a population-based cohort of 439 patients with colorectal cancer from Saarland (Germany) using the EORTC-QLC30 questionnaire. Specific functional and symptom QOL scores were compared with published reference data from the general population.
  
  
  RESULTS
  Of 439 patients, 378 of them survived the first year after tumor diagnosis (86.1%). Of these, 309 returned the questionnaire (response rate, 81.7%). Compared with the general population, colorectal cancer patients scored their physical, role, cognitive, and global health functioning only slightly worse. More severe limitations were observed for the emotional and social functioning scales and for the symptom subscales of fatigue, dyspnea, insomnia, constipation, diarrhea, and financial difficulties. The differences regarding functional and symptom scores were predominantly found in younger age groups whereas older cancer patients and controls rated their health and QOL similarly.
  
  
  CONCLUSIONS
  Deficits in emotional and social functioning and specific limitations like fatigue, dyspnea, insomnia, constipation, diarrhea, and financial difficulties are main factors hampering the QOL among colorectal cancer patients and seem to affect predominantly younger patients.
authors.affiliation: Department of Epidemiology, German Centre for Research on Aging, Heidelberg, Germany. arndt@dzfa.uni-heidelberg.de
authors.forename: Volker
authors.initials: V
authors.lastname: Arndt
authors.forename: Henrike
authors.initials: H
authors.lastname: Merx
authors.forename: Christa
authors.initials: C
authors.lastname: Stegmaier
authors.forename: Hartwig
authors.initials: H
authors.lastname: Ziegler
authors.forename: Hermann
authors.initials: H
authors.lastname: Brenner
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D003082:Colectomy / Q000379:methods; D015179:Colorectal Neoplasms / Q000473:pathology / Q000523:psychology* / Q000628:therapy*; D003131:Combined Modality Therapy; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011788:Quality of Life; D018570:Risk Assessment; D012737:Sex Factors; D018434:Sickness Impact Profile; D012917:Social Adjustment; D011795:Surveys and Questionnaires; D013997:Time Factors