GTP concentrations are elevated in erythrocytes of renal transplant recipients when conventional immunosuppression is replaced by the inosine monophosphate dehydrogenase inhibitor mycophenolic acid mofetil (MMF).
We show that GTP concentrations rise in the erythrocytes of renal transplant recipients receiving the immunosuppressant MMF, and demonstrate that this effect is not caused by poor renal function after engraftment. We propose a model that is consistent with our observations.
Goldsmith
D J A
DJ
Purine Research Unit, Department of Renal Medicine, Thomas Guy House, Guy's Hospital, London, UK.
Carrey
E A
EA
Edbury
S M
SM
Marinaki
A M
AM
Simmonds
H A
HA
D001379:Azathioprine / Q000494:pharmacology*; D001665:Binding Sites; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000097:blood; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism*; D006084:Graft Rejection; D006160:Guanosine Triphosphate / Q000378:metabolism*; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016030:Kidney Transplantation; D013997:Time Factors; D015854:Up-Regulation
D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D006160:Guanosine Triphosphate; D003404:Creatinine; D007168:IMP Dehydrogenase; D001379:Azathioprine