Allergy to cocamidopropyl betaine and amidoamine in North America.
BACKGROUND
The prevalence of allergy to cocamidopropyl betaine (CAPB) in North America has not been previously reported.


OBJECTIVE
The aim of this study was to report on the most recent data on allergy to CAPB and a related allergen, amidoamine (AA).


METHODS
Data was collected by the North American Contact Dermatitis Group from consecutive patients presenting for patch testing for diagnosis of presumed allergic contact dermatitis (ACD) from January 1, 2001, through December 31, 2001.


RESULTS
Of 975 patients tested, 15 were patch-test positive to CAPB, 25 had positive reactions to AA, and 18 had positive reactions to both CAPB and AA. The most frequent site of dermatitis from CAPB was the head and neck region.


CONCLUSIONS
In North America, both CAPB and AA are useful allergens for detecting ACD.
Fowler
Joseph F
JF
North American Contact Dermatitis Group, USA.
Zug
Kathryn M
KM
Taylor
James S
JS
Storrs
Frances J
FJ
Sherertz
Elizabeth A
EA
Sasseville
Denis A
DA
Rietschel
Robert L
RL
Pratt
Melanie D
MD
Mathias
C G Toby
CG
Marks
James G
JG
Maibach
Howard I
HI
Fransway
Anthony F
AF
Deleo
Vincent A
VA
Belsito
Donald V
DV
D000485:Allergens / Q000009:adverse effects*; D000588:Amines / Q000009:adverse effects*; D001622:Betaine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D005148:Facial Dermatoses / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008499:Medical Records; D010328:Patch Tests; D015995:Prevalence; D012189:Retrospective Studies; D013501:Surface-Active Agents / Q000009:adverse effects*; D014481:United States / Q000453:epidemiology
D000485:Allergens; D000588:Amines; D013501:Surface-Active Agents; D001622:Betaine; C077055:cocamidopropyl betaine