[Medical-prophylactic properties of the low-molecular-weight chitosan at environmental radiation injury].
The possibility of the successful modification of radiation injury by chitosan with low molecular weight (10 kDa) has been established under experimental conditions. The survival of mice increased up to 72.7 and 44.7% respectively at intravenous and intramuscular injection 30 min before gamma-irradiation with a dose 8 Gy (LD97). In guinea pigs the effect was 50-52.6% at intravenous and 40% at intramuscular administration 1-3 h after irradiation with a dose 5 Gy (LD90). Radioprotective efficiency of 10 kDa chitosan is close to that of high-molecular-weight (65-70 kDa) preceding (medicine RS-10 and RS-11).
Il'in
L A
LA
Andrianova
I E
IE
Glushkov
V A
VA
Bannikova
G E
GE
Varlamov
V P
VP
D000818:Animals; D048271:Chitosan / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008970:Molecular Weight; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*
D011837:Radiation-Protective Agents; D048271:Chitosan