title: [Application of Mesim Forte 10000 at chronic pancreatitis].
abstract: There was a study of 30 patients with chronic pancreatitis (CP) to study the efficiency of action of Mesim Forte 10000 on the functional state of the pancreas and liver at chronic pancreatitis. Patients were given two pills of the drug three times a day during three weeks. The pancreatic elastase and contents of short chain fatty acids in excrements as well as blood concentration of individual fractions of bile acids were investigated before and after the treatment. According to this research, such clinical presentations of CP as pain syndrome, meteorism and stool frequency were greatly reduced as a result of the therapy with the enzymatic drug Mesim Forte 10000. The increase of the level of the pancreatic elastase depending on the severity of exocrine pancreatic deficiency was determined. At the same time, it was possible to observe the correction of a number of biochemical processes in the gastrointestinal tract related to the exocrine deficiency. In particular, the treatment of the greater part of steatorrhea patients with Mesim Forte 10000 led to apparent changes in the metabolic activity of bacterial microflora resulting in the improvement of the quantity and quality of fatty acids.
authors.forename: L V
authors.initials: LV
authors.lastname: Vinokurova
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Sil'vestrova
authors.forename: O V
authors.initials: OV
authors.lastname: Astaf'eva
authors.forename: S G
authors.initials: SG
authors.lastname: Shustova
mesh_terms: D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000097:blood; D002908:Chronic Disease; D005227:Fatty Acids / Q000032:analysis; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects; D010196:Pancreatic Elastase / Q000032:analysis; D010195:Pancreatitis / Q000188:drug therapy*
chemical_list: D001647:Bile Acids and Salts; D005227:Fatty Acids; D010196:Pancreatic Elastase