[Toxicological characterization of calcium ketopantoylaminobutyrate].
The investigation of toxicity of calcium ketopantoylaminobutyrate (Ca-KPAB) showed that this newly synthesized compound belongs to the class of low-toxicity substances. The LD 50 of Ca-KPAB for oral administration is lower than that of pantogam. No toxicity manifestations and local irritant activity was observed upon chronic administration of Ca-KPAB. The therapeutic index of Ca-KPAB is more than 17 times that of pantogam.
Karaev
A L
AL
Kozlova
G S
GS
Smirnova
T N
TN
Gunar
V I
VI
D000284:Administration, Oral; D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000633:toxicity
C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid