title: [The use of clomiphene citrate in ambulatory medicine practice in the Midi-Pyrénées area: compliance to national guidelines applicable to infertility diagnosis and to prescription and monitoring rules applicable to clomiphene citrate treatments].
abstract: OBJECTIVE
  Evaluate the compliance to the national guidelines from ANDEM (1996) and AFSSAPS (2003) concerning the diagnosis of infertility, the prescription of clomiphene and the monitoring of these treatments.
  
  
  METHODS
  Retrospective study of female patients from 16 to 50 y.o. having benefited from reimbursement of clomiphene citrate treatment between 1st April 2002 and 30th June 2002. After random sampling stratified on age, data on diagnosis procedures and treatments were extracted from the Social Security reimbursement database. These data were validated and completed by patients' interviews.
  
  
  RESULTS
  A total of 283 women were included. 30% were subject to the basic hormonal tests (FSH, LH, estradiol). The proportion of patients explored by hysterosalpingogram, post-coital test and echography were respectively 50%, 35% and 68%. A semen analysis was found in 60% of the partners. The complete set of recommended tests before start of treatment was realised in 1.5% of women. In 7% of cases, women were treated without prior exploration. The proportion of tests performed was comparable below and above the age of 35. 77% of treatments were initiated after at least one year of waiting for a spontaneous conception. 69% of women were monitored during treatment by other methods than clinical follow-up.
  
  
  CONCLUSIONS
  Prescription of clomifene citrate is too frequently realised without compliance to guidelines applicable to infertility investigations and therefore without persuasive diagnosis. These practices can lead to loss of childbearing opportunities and complications.
authors.affiliation: Direction régionale du service médical de Midi-Pyrénées (DRSM), CNAMTS, 2, rue Georges-Vivent, 31082 Toulouse, France. valerie.bigouroux@ersm-midipyr.cnamts.fr
authors.forename: V
authors.initials: V
authors.lastname: Bigouroux
authors.forename: H
authors.initials: H
authors.lastname: Roussel
authors.forename: A
authors.initials: A
authors.lastname: Souche
authors.forename: R
authors.initials: R
authors.lastname: Bourrel
authors.forename: V
authors.initials: V
authors.lastname: Sciortino
mesh_terms: D000328:Adult; D000553:Ambulatory Care / Q000592:standards*; D002996:Clomiphene / Q000008:administration & dosage*; D005260:Female; D005602:France; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D012661:Semen / Q000502:physiology
chemical_list: D002996:Clomiphene