title: Pediatric Vision Screener 2: pilot study in adults.
abstract: Amblyopia is a form of visual impairment caused by ocular misalignment (strabismus) or defocus in an otherwise healthy eye. If detected early, the condition can be fully treated, yet over half of all children with amblyopia under age 5 escape detection. We developed a Pediatric Vision Screener (PVS) to detect amblyopia risk factors. This instrument produces a binocularity score to indicate alignment and a focus score to indicate focus. The purpose of this study is to assess the performance of the PVS by testing adults who were fully cooperative for testing. The study group includes 40 subjects (20 controls, 20 patients) aged 22 to 79 years. 12 patients had constant strabismus (8 to 50Delta), and eight had variable strabismus (12 to 55Delta). All controls had binocularity scores >50%. Binocularity was <50% in 11/12 patients. The patient with binocularity >50% had a well-controlled intermittent exotropia and was not at risk for amblyopia. Focus scores were highly sensitive for good focus but not specific. The PVS shows high sensitivity and specificity for detection of strabismus in adults. Future studies will determine whether this performance can be achieved in preschool children, who are at greatest risk for vision loss.
authors.affiliation: Harvard Medical School, Children's Hospital Boston, Department of Ophthalmology, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
authors.forename: Deborah S
authors.initials: DS
authors.lastname: Nassif
authors.forename: Nadya V
authors.initials: NV
authors.lastname: Piskun
authors.forename: Boris I
authors.initials: BI
authors.lastname: Gramatikov
authors.forename: David L
authors.initials: DL
authors.lastname: Guyton
authors.forename: David G
authors.initials: DG
authors.lastname: Hunter
mesh_terms: D000328:Adult; D000368:Aged; D000550:Amblyopia / Q000175:diagnosis* / Q000209:etiology; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055095:Optics and Photonics / Q000295:instrumentation*; D010372:Pediatrics / Q000295:instrumentation* / Q000379:methods; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013285:Strabismus / Q000150:complications / Q000175:diagnosis*; D014584:User-Computer Interface; D014787:Vision Tests / Q000295:instrumentation* / Q000379:methods