title: Renal transplant recipient with chronic hepatitis C who obtained sustained viral response after interferon-beta therapy.
abstract: A 44-year-old Japanese woman with a history of living-related renal transplantation was treated with interferon-beta (IFN-beta) for chronic infection with sero-group 2 hepatitis C virus (HCV). Serum HCV-RNA titer was 160 kilo-international units/ml. Treatment with intravenous IFN-beta daily was given for 6 weeks. Serum HCV-RNA was undetectable at 3 weeks after initiating therapy. Renal graft rejection did not occur. Six months after completing therapy, she obtained sustained viral response. This case demonstrates that IFN-beta therapy safely induced clearance of HCV in a renal transplant recipient with stable renal function, low viral load and/or HCV sero-group 2.
authors.affiliation: Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobucho, Onsen-gun, Ehime 791-0295.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Konishi
authors.forename: Norio
authors.initials: N
authors.lastname: Horiike
authors.forename: Kojiro
authors.initials: K
authors.lastname: Michitaka
authors.forename: Nobuko
authors.initials: N
authors.lastname: Ochi
authors.forename: Shinya
authors.initials: S
authors.lastname: Furukawa
authors.forename: Hisaka
authors.initials: H
authors.lastname: Minami
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D007564:Japan; D016030:Kidney Transplantation; D012367:RNA, Viral / Q000097:blood; D014180:Transplantation; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D016899:Interferon-beta