title: Correlation of entorhinal amyloid with memory in Alzheimer's and vascular but not Lewy body dementia.
abstract: OBJECTIVE
  To examine the relationship of the anatomic distribution of amyloid deposition to focal and global cognitive dysfunction in different subtypes of dementia.
  
  
  METHODS
  We quantified AB40 and AB42 in the temporal lobe and entorhinal cortex and examined their relationship to cognitive functions in Alzheimer's disease (AD), vascular dementia (VaD) and dementia with Lewy bodies (DLB).
  
  
  RESULTS
  We found a correlation between memory impairment, but not global cognitive impairment, and amyloid load in these areas in AD and VaD but not in DLB. This relationship was stronger for AB42 and in the entorhinal cortex.
  
  
  CONCLUSIONS
  The anatomic location of amyloid deposition is an important factor-specific factor in memory impairment in AD and VaD.
authors.affiliation: Institute for Ageing and Health, Newcastle, UK.
authors.forename: Alan
authors.initials: A
authors.lastname: Thomas
authors.forename: Clive
authors.initials: C
authors.lastname: Ballard
authors.forename: Rose Anne
authors.initials: RA
authors.lastname: Kenny
authors.forename: John
authors.initials: J
authors.lastname: O'Brien
authors.forename: Arthur
authors.initials: A
authors.lastname: Oakley
authors.forename: Raj
authors.initials: R
authors.lastname: Kalaria
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology; D000682:Amyloid / Q000032:analysis*; D002540:Cerebral Cortex / Q000473:pathology; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000473:pathology; D018728:Entorhinal Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008568:Memory / Q000502:physiology*; D008609:Mental Status Schedule; D008853:Microscopy; D009483:Neuropsychological Tests; D013223:Statistics as Topic; D013702:Temporal Lobe / Q000473:pathology
chemical_list: D000682:Amyloid