Malignant rhabdoid tumor of the kidney in a child: report of a case with recurrence in the contralateral kidney.
BACKGROUND
Malignant rhabdoid tumor (MRT) of the kidney is a rare and aggressive neoplasm with a controversial histogenesis. Although their immunohistochemistry may be diverse, the rhabdoid phenotype and mutations of the INI1 gene are consistently exhibited by MRTs regardless of their location.


METHODS
MRT recurred in the contralateral kidney in a 12-month-old child within 6 months after the initial histologic diagnosis, nephrectomy and autologous stem cell transplant. The presence of widespread metastases at the time of the recurrence precluded any further chemical and surgical diagnostic or therapeutic intervention.


CONCLUSIONS
To the best of our knowledge, only a few cases describing the cytologic diagnosis of MRT of the kidney in a child have been reported. This case illustrates the usefulness of cytologic diagnosis in an MRT recurrence.
Cocker
Rubina S
RS
Department of Pathology, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA.
Sharaan
Mona
M
Wasserman
Patricia
P
D014408:Biomarkers, Tumor; D044963:Biopsy, Fine-Needle; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D018450:Disease Progression; D017809:Fatal Outcome; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007633:Keratins / Q000378:metabolism; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging / Q000473:pathology; D009392:Nephrectomy; D011859:Radiography; D012008:Recurrence; D018335:Rhabdoid Tumor / Q000000981:diagnostic imaging / Q000473:pathology* / Q000556:secondary; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous; D014746:Vimentin / Q000378:metabolism
D014408:Biomarkers, Tumor; D014746:Vimentin; D007633:Keratins