title: Is the nocturnal fall in blood pressure reduced in essential hypertensive patients with metabolic syndrome?
abstract: OBJECTIVE
  The aim of this study was to examine whether an impaired reduction in nocturnal blood pressure (BP), defined on the basis of two periods of ambulatory BP monitoring (ABPM), is present in hypertensive patients with metabolic syndrome, as defined by the NCEP criteria.
  
  
  METHODS
  460 grade 1 and 2 untreated essential hypertensives (mean age 45.9 +/- 11.9 years) referred for the first time to our outpatient hospital clinic underwent the following procedures: 1) medical history and physical examination; 2) repeated clinic BP measurements; 3) routine examinations; 4) ABPM over two 24-hour periods within 4 weeks. Metabolic syndrome was defined as at least three of the following alterations: increased waist circumference, increased triglycerides, decreased HDL-cholesterol, increased BP, or high fasting glucose. Nocturnal dipping was defined as a night-time reduction in average SBP and DBP >10% compared to average daytime values.
  
  
  RESULTS
  The 135 patients with metabolic syndrome (group I) were similar for age, gender and known duration of hypertension to the 325 patients without it (group II). There were no significant differences between the two groups in average 48-hour, daytime, night-time SBP/DBP values and the percentage nocturnal SBP and DBP decrease (-17.7 / -15.7 vs. -18.4 / -16.2, p = ns). A reproducible nocturnal dipping (decrease in BP >10% from mean daytime in both ABPM periods) and non-dipping profile (decrease in BP < or =10% in both ABPM periods) was found in 74 (54.8%) and 29 (21.4%) in group I and in 169 (52.1%) and 73 (22.4%) in group II, respectively (p = ns); 32 patients (23.7%) in group I and 83 patients (25.5%) in group II had a variable dipping profile (p = ns).
  
  
  CONCLUSIONS
  This study shows that no significant difference exists in nocturnal BP patterns, assessed by two ABPMs, in untreated essential hypertensive patients with metabolic syndrome compared to those without it.
authors.affiliation: Istituto di Medicina Cardiovascolare, Centro di Fisiologia Clinica e Ipertensione, Università degli Studi di Milano, Ospedale Maggiore Policlinico, IRCCS, Milano, Italy, Università degli Studi di Milano, Italy. dhipertensione@libero.it
authors.forename: Cesare
authors.initials: C
authors.lastname: Cuspidi
authors.forename: Stefano
authors.initials: S
authors.lastname: Meani
authors.forename: Veronica
authors.initials: V
authors.lastname: Fusi
authors.forename: Barbara
authors.initials: B
authors.lastname: Severgnini
authors.forename: Cristiana
authors.initials: C
authors.lastname: Valerio
authors.forename: Eleonora
authors.initials: E
authors.lastname: Catini
authors.forename: Carla
authors.initials: C
authors.lastname: Sala
authors.forename: Fabio
authors.initials: F
authors.lastname: Magrini
authors.forename: Alberto
authors.initials: A
authors.lastname: Zanchetti
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000503:physiopathology*; D008875:Middle Aged