Defining target volumes for non-small cell lung carcinoma.
The definition of target volumes for non-small cell lung carcinoma (NSCLC) remains a controversial topic as tradition-based approaches of the past are being critically re-evaluated in the light of the advent of three-dimensional treatment techniques, by the awareness of the poor local control achieved using current treatment fields and radiation doses, and by the major improvements in noninvasive staging that enable the gross tumor volume to be established with greater accuracy. This article reviews the current knowledge and remaining uncertainties in defining target volumes for NSCLC. The use of these new approaches may allow for improvements in the therapeutic ratio of radiotherapy in NSCLC.
Senan
Suresh
S
Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands.
Chapet
Olivier
O
Lagerwaard
Frank J
FJ
Ten Haken
Randall K
RK
D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D008207:Lymphatic Metastasis / Q000532:radiotherapy; D009367:Neoplasm Staging; D019275:Radiopharmaceuticals; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods*; D014055:Tomography, Emission-Computed
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18