title: [The role of caveolin-1 gene in carcinogenesis].
abstract: Caveolin-1 is responsible for the development of caveolae, which are vesicular invaginations of the plasma membrane, and plays a key role in membrane traffic and signal transduction. The role of caveolin-1 in carcinogenesis has been a subject to numerous investigations, however, the expression pattern and the function of caveolin-1 are rather controversial both in gastrointestinal and extraintestinal cancers. The vast majority of results based on cancer cell line experiments indicate that caveolin-1 might act as a tumor suppressor gene. In tumor tissues, however, caveolin-1 seem to fulfill a tumor promoting role, since the expression of caveolin-1 is increased when compared to normal tissue counterparts. In this review, the authors summarize the results of caveolin-1 expression in gastrointestinal and extraintestinal cancer emphasizing possible future therapeutic implications.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belgyógyászati Klinika, Budapest.
authors.forename: Márk
authors.initials: M
authors.lastname: Juhász
authors.forename: Márton
authors.initials: M
authors.lastname: Vértesaljai
authors.forename: László
authors.initials: L
authors.lastname: Herszényi
authors.forename: Peter
authors.initials: P
authors.lastname: Malfertheiner
authors.forename: Matthias P A
authors.initials: MP
authors.lastname: Ebert
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Tulassay
mesh_terms: D000818:Animals; D051242:Caveolin 1; D022461:Caveolins / Q000235:genetics*; D002462:Cell Membrane / Q000378:metabolism; D005770:Gastrointestinal Neoplasms / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D015398:Signal Transduction
chemical_list: C495540:CAV1 protein, human; D051242:Caveolin 1; D022461:Caveolins