Neurofilament proteins in neurodegenerative diseases.
The function of neurofilaments, the major component in large myelinated neurons, is not well understood even though they were discovered as structures over 100 years ago. Recent studies have suggested that neuro-filaments are closely related to many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson disease Alzheimer disease, and diabetes. Using in vitro assays, cultures and transgenic mice, these studies provided new insights into neurofilament function. The function of each subunit, the relationship of neurofilaments with other cytoskeletal elements and their clinical significance are topics of increasing attention.
Liu
Q
Q
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA. quan.liu@case.edu
Xie
F
F
Siedlak
S L
SL
Nunomura
A
A
Honda
K
K
Moreira
P I
PI
Zhua
X
X
Smith
M A
MA
Perry
G
G
D000818:Animals; D001692:Biological Transport; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D016900:Neurofilament Proteins / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
D016900:Neurofilament Proteins