Tegaserod (HTF 919) stimulates gut motility in normal horses.
BACKGROUND
It has been shown that the selective 5-HT4 receptor agonist tegaserod induces an increase in frequency and amplitude of contractions in isolated muscle preparations of equine ileum and pelvic flexure.


OBJECTIVE
To investigate the effects of tegaserod on gut motility and transit of spheres in normal horses.


METHODS
Six mature Freiberger horses were kept under standardised conditions. Effects of tegaserod (0.02 mg/kg bwt i.v. b.i.d. for 2 days) or vehicle on intestinal transit of barium-filled spheres, defaecation and gut sounds were studied in a cross-over design. Spheres were given via stomach tube prior to the first dosing of tegaserod or vehicle. Faeces were collected every 3 h and spheres eliminated were identified radiologically in the faeces.


RESULTS
Tegaserod significantly accelerated the gastrointestinal (GI) transit time of spheres and increased the frequency of defaecation and scores of gut sounds compared to vehicle. The compound was well tolerated; no effects on behaviour, body temperature, heart rate, respiratory rate and clinical laboratory data were observed.


CONCLUSIONS
Tegaserod efficaciously stimulated motility and accelerate GI transit in healthy horses.


CONCLUSIONS
Tegaserod may offer therapeutic potential in horses suffering from impaction or paralytic ileus.
Lippold
B S
BS
Equine Clinic, Department of Clinical Veterinary Medicine, University of Berne, Laenggassstrasse 124, 3012 Berne, Switzerland.
Hildebrand
J
J
Straub
R
R
D000818:Animals; D018592:Cross-Over Studies; D003672:Defecation / Q000187:drug effects; D005244:Fecal Impaction / Q000188:drug therapy / Q000662:veterinary; D005243:Feces; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006734:Horse Diseases / Q000188:drug therapy; D006736:Horses; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D005765:Gastrointestinal Agents; D007211:Indoles; D017366:Serotonin Receptor Agonists; C105050:tegaserod