title: [Undifferentiated, overlapping and mixed connective tissue diseases].
abstract: Mixed connective tissue disease (MCTD), undifferentiated connective tissue disease and overlap syndromes are autoimmune systemic diseases that must be differentiated. Antibodies against the U1-ribonucleoprotein complex --spliceosome-- allows the diagnosis of mixed connective tissue disease. Links between the immunologic and clinical phenomena are emerging. Longitudinal studies of patients with MCTD highlight the impact of pulmonary hypertension and contribute to define the disease. Immunogenetic studies hold MCTD as an independent disease.
authors.affiliation: Servicio de Medicina Interna, Hospital General Vall d'Hebron, Barcelona, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: Ruiz Pombo
authors.forename: Moisés
authors.initials: M
authors.lastname: Labrador Horrillo
authors.forename: Albert
authors.initials: A
authors.lastname: Selva O'Callaghan
mesh_terms: D000906:Antibodies / Q000276:immunology; D006801:Humans; D008947:Mixed Connective Tissue Disease / Q000145:classification* / Q000175:diagnosis / Q000276:immunology; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000276:immunology
chemical_list: D000906:Antibodies; D017412:Ribonucleoprotein, U1 Small Nuclear