title: Pathway analysis for population-total health impacts of toxic metal emissions.
abstract: This article describes a simple model for quantifying the health impacts of toxic metal emissions. In contrast to most traditional models it calculates the expectation value of the total damage (summed over the total population and over all time) for typical emission sites, rather than "worst-case" estimates for specific sites or episodes. Such a model is needed for the evaluation of many environmental policy measures, e.g., the optimal level of pollution taxes or emission limits. Based on the methodology that has been developed by USEPA for the assessment of multimedia pathways, the equations and parameters are assembled for the assessment of As, Cd, Cr, Hg, Ni, and Pb, and some typical results are presented (the dose from seafood is not included and for Hg the results are extremely uncertain); the model is freely available on the web. The structure of the model is very simple because, as we show, if the parameters can be approximated by time-independent constants (the case for the USEPA methodology), the total impacts can be calculated with steady-state models even though the environment is never in steady state. The collective ingestion dose is found to be roughly 2 orders of magnitude larger than the collective dose via inhalation. The uncertainties are large, easily an order of magnitude, the main uncertainties arising from the parameter values of the model, in particular the transfer factors. Using linearized dose-response functions, estimates are provided for cancers due to As, Cd, Cr, and Ni as well as IQ loss due to Pb emissions in Europe.
authors.affiliation: Centre d'Energétique, Ecole des Mines, Paris, Cedex 06, France.
authors.forename: Joseph V
authors.initials: JV
authors.lastname: Spadaro
authors.forename: Ari
authors.initials: A
authors.lastname: Rabl
mesh_terms: D000393:Air Pollutants / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000633:toxicity*; D005506:Food Contamination; D006801:Humans; D019216:Metals, Heavy / Q000008:administration & dosage / Q000633:toxicity*; D008954:Models, Biological; D009369:Neoplasms / Q000139:chemically induced; D011634:Public Health; D018570:Risk Assessment; D012989:Soil Pollutants / Q000008:administration & dosage / Q000633:toxicity; D014874:Water Pollutants, Chemical / Q000008:administration & dosage / Q000633:toxicity
chemical_list: D000393:Air Pollutants; D004785:Environmental Pollutants; D019216:Metals, Heavy; D012989:Soil Pollutants; D014874:Water Pollutants, Chemical