title: Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase.
abstract: A novel series of heterocyclic sulfoxides and sulfones was prepared and examined as potential inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for inactivation of neuromodulating fatty acid amides including anandamide and oleamide.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Wu
authors.initials: W
authors.lastname: Du
authors.forename: Christophe
authors.initials: C
authors.lastname: Hardouin
authors.forename: Heng
authors.initials: H
authors.lastname: Cheng
authors.forename: Inkyu
authors.initials: I
authors.lastname: Hwang
authors.forename: Dale L
authors.initials: DL
authors.lastname: Boger
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*; D013454:Sulfoxides / Q000737:chemistry*; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D013450:Sulfones; D013454:Sulfoxides; D000099252:Fatty Acid Amide Hydrolases