High-fat corn oil diet promotes the development of high histologic grade rat DMBA-induced mammary adenocarcinomas, while high olive oil diet does not.
Effects of a high corn oil and a high olive oil diet on the histopathologic characteristics of rat dimethylbenz(alpha)anthracene-induced mammary adenocarcinomas were investigated in comparison with those of a control low-fat diet. Two experimental series (A and B) studied the influence of a high corn oil diet on the initiation and the promotion of mammary carcinogenesis, while another one (C) assessed the effects of the two dietary lipids on the promotion. Nine parameters have been analyzed and a new histologic grading method, adapted to rat tumors, has been applied in each carcinoma. High corn oil diets, particularly when acting as promoters, associated with higher-grade carcinomas than control (p < 0.05) and high olive oil groups. Stromal invasion and tumoral necrosis were more prominent and a prevailing cribriform pattern was observed (p < 0.05). High olive oil diet adenocarcinomas exhibited a predominantly low histologic grade and few necrotic and invasive areas, similar to the control, and they presented the highest percentage of papillary areas. Lymphoplasmacytic and mast cell infiltration were also influenced by the dietary lipids. Thus, high corn oil diet adenocarcinomas presented a higher degree of morphological malignancy than control and high olive oil tumors, which is in line with the greater clinical malignancy described in rats from the former group and the non-promoting effect of the high olive oil diet. As far as we are concerned, a similar histopathologic approach of the effects of the dietary lipids on experimental breast cancer has not been carried out up to now.
Costa
Irmgard
I
Department of Cell Biology, Physiology and Immunology, Physiology Unit, Medical School, Universitat Autònoma de Barcelona, Barcelona, Spain.
Moral
Raquel
R
Solanas
Montserrat
M
Escrich
Eduard
E
D000230:Adenocarcinoma / Q000503:physiopathology*; D000821:Animal Feed; D000818:Animals; D001943:Breast Neoplasms / Q000503:physiopathology*; D002471:Cell Transformation, Neoplastic; D003314:Corn Oil / Q000009:adverse effects*; D004041:Dietary Fats / Q000009:adverse effects*; D004195:Disease Models, Animal; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000503:physiopathology*; D009374:Neoplasms, Experimental; D000069463:Olive Oil; D010938:Plant Oils / Q000494:pharmacology*; D011379:Prognosis; D051381:Rats; D017207:Rats, Sprague-Dawley
D004041:Dietary Fats; D000069463:Olive Oil; D010938:Plant Oils; D003314:Corn Oil