title: Pro12Ala substitution in peroxisome proliferator-activated receptor gamma 2 is associated with low adiponectin concentrations in young Japanese men.
abstract: Peroxisome proliferator-activated receptor gamma (PPAR gamma) has been shown to play an important role in adipocyte differentiation. A Pro12Ala substitution in PPAR gamma 2 has been reported to decrease receptor activity in vitro and to be associated with a decreased risk of type 2 diabetes in the general population. Recently, a PPAR response element (PPRE) was identified in the adiponectin promoter, suggesting that decreased PPAR gamma activity may lead to lower adiponectin levels. In the present study, serum adiponectin concentrations and the PPAR gamma Pro12Ala polymorphism were analyzed to determine whether this polymorphism is associated with lower serum adiponectin concentrations in young healthy Japanese subjects. Serum adiponectin concentrations were significantly lower in men with than in those without the Ala12 allele, whereas body mass index (BMI), homeostasis model assessment (HOMA)-beta, HOMA-IR, the insulin sensitivity index during oral glucose tolerance test (ISI [composite]), and serum leptin did not differ significantly between subjects with and without the Ala12 allele. Stepwise regression demonstrated BMI and the Ala12 allele to be independent predictors of serum adiponectin concentrations in men. In conclusion, the Pro12Ala substitution in PPAR gamma 2 may reduce serum adiponectin concentrations in young Japanese men.
authors.affiliation: Division of Endocrinoloy and Diabetes, Department of Medicine, Saitama Medical School, Saitama 350-0495, Japan.
authors.forename: Nobuki
authors.initials: N
authors.lastname: Takata
authors.forename: Takuya
authors.initials: T
authors.lastname: Awata
authors.forename: Kouichi
authors.initials: K
authors.lastname: Inukai
authors.forename: Masaki
authors.initials: M
authors.lastname: Watanabe
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ohkubo
authors.forename: Susumu
authors.initials: S
authors.lastname: Kurihara
authors.forename: Munemichi
authors.initials: M
authors.lastname: Inaba
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Katayama
mesh_terms: D052242:Adiponectin; D000328:Adult; D019943:Amino Acid Substitution; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D005838:Genotype; D005951:Glucose Tolerance Test; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D020738:Leptin / Q000097:blood; D008297:Male; D015999:Multivariate Analysis; D047495:PPAR gamma / Q000235:genetics*; D012044:Regression Analysis
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D047495:PPAR gamma