title: The SIS extracellular matrix scaffold-preliminary results of use in congenital diaphragmatic hernia (CDH) repair.
abstract: There is no ideal bio-tensile material for tissue replacement in paediatric surgical conditions. A variety of materials have been described to replace or reinforce tissue deficits in congenital diaphragmatic hernia (CDH). The problems with these materials range from extensive surgery to body wall deformity and hernia recurrence. The ideal graft would be safe, strong, have the potential to grow and not require replacement, not affect chest wall development or produce deformity, and have minimal risk of recurrence. Surgisis is a biomaterial composed of porcine intestinal submucosa that provides inherent tensile strength as a collagen lattice and is ultimately replaced by native collagen tissue. Our objective was to prospectively assess the utility of Surgisis as a replacement graft in a cohort of 10 children undergoing primary or recurrent CDH repair. The graft was well tolerated, and there was no recurrence of herniation. We conclude that Surgisis collagen mesh may be a useful alternative for tissue replacement or reinforcement in difficult cases of CDH and diaphragmatic agenesis. The biological framework of Surgisis may also prove useful in other situations of complex tissue loss in children.
authors.affiliation: Department of Paediatric Surgery, Our Lady's Hospital for Sick Children, 12 Crumlin, Dublin, Ireland. mylessmith@iolfree.ie
authors.forename: M J
authors.initials: MJ
authors.lastname: Smith
authors.forename: T S
authors.initials: TS
authors.lastname: Paran
authors.forename: F
authors.initials: F
authors.lastname: Quinn
authors.forename: M T
authors.initials: MT
authors.lastname: Corbally
mesh_terms: D005109:Extracellular Matrix; D005260:Female; D006548:Hernia, Diaphragmatic / Q000601:surgery*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008567:Membranes, Artificial; D011446:Prospective Studies
chemical_list: D008567:Membranes, Artificial