title: Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people.
abstract: OBJECTIVE
  To investigate the relation between cannabis use and psychotic symptoms in individuals with above average predisposition for psychosis who first used cannabis during adolescence.
  
  
  METHODS
  Analysis of prospective data from a population based sample. Assessment of substance use, predisposition for psychosis, and psychotic symptoms was based on standardised personal interviews at baseline and at follow up four years later.
  
  
  METHODS
  2437 young people (aged 14 to 24 years) with and without predisposition for psychosis.
  
  
  METHODS
  Psychotic symptoms at follow up as a function of cannabis use and predisposition for psychosis at baseline.
  
  
  RESULTS
  After adjustment for age, sex, socioeconomic status, urbanicity, childhood trauma, predisposition for psychosis at baseline, and use of other drugs, tobacco, and alcohol, cannabis use at baseline increased the cumulative incidence of psychotic symptoms at follow up four years later (adjusted odds ratio 1.67, 95% confidence interval 1.13 to 2.46). The effect of cannabis use was much stronger in those with any predisposition for psychosis at baseline (23.8% adjusted difference in risk, 95% confidence interval 7.9 to 39.7, P = 0.003) than in those without (5.6%, 0.4 to 10.8, P = 0.033). The risk difference in the "predisposition" group was significantly greater than the risk difference in the "no predisposition" group (test for interaction 18.2%, 1.6 to 34.8, P = 0.032). There was a dose-response relation with increasing frequency of cannabis use. Predisposition for psychosis at baseline did not significantly predict cannabis use four years later (adjusted odds ratio 1.42, 95% confidence interval 0.88 to 2.31).
  
  
  CONCLUSIONS
  Cannabis use moderately increases the risk of psychotic symptoms in young people but has a much stronger effect in those with evidence of predisposition for psychosis.
authors.affiliation: Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO BOX 616, 6200 MD Maastricht, Netherlands.
authors.forename: Cécile
authors.initials: C
authors.lastname: Henquet
authors.forename: Lydia
authors.initials: L
authors.lastname: Krabbendam
authors.forename: Janneke
authors.initials: J
authors.lastname: Spauwen
authors.forename: Charles
authors.initials: C
authors.lastname: Kaplan
authors.forename: Roselind
authors.initials: R
authors.lastname: Lieb
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Wittchen
authors.forename: Jim
authors.initials: J
authors.lastname: van Os
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D004198:Disease Susceptibility; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000523:psychology*; D011446:Prospective Studies; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D012307:Risk Factors