title: Seronegative alpha-fetoprotein-producing early gastric cancer treated with endoscopic mucosal resection and additional surgery.
abstract: A 67-year-old man visited our hospital for the treatment of gastric carcinoma. Endoscopic mucosal resection was performed, however, histological examination of the resected specimen revealed tumor invasion to the submucosal layer with vessel invasion. Immunohistological studies were carried out on resected specimens and part of the cancerous lesion showed a positive reaction for alpha-fetoprotein (AFP), but the serum AFP level was normal. Additional distal gastrectomy with lymph node dissection revealed lymph node metastasis although there was no apparent finding of lymph node swelling by preoperative diagnostic imaging. This patient remains alive without disease for 3 years after surgery.
authors.affiliation: Department of Internal Medicine, Shikoku Cancer Center, 13 Horino-uchi, Matsuyama 790-0007.
authors.forename: Shoji
authors.initials: S
authors.lastname: Hirasaki
authors.forename: Masahito
authors.initials: M
authors.lastname: Tanimizu
authors.forename: Takao
authors.initials: T
authors.lastname: Tsuzuki
authors.forename: Eiji
authors.initials: E
authors.lastname: Tsubouchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hidaka
authors.forename: Ichinosuke
authors.initials: I
authors.lastname: Hyodo
authors.forename: Hisao
authors.initials: H
authors.lastname: Tajiri
mesh_terms: D000368:Aged; D020776:Endoscopes, Gastrointestinal; D016099:Endoscopy, Gastrointestinal; D006801:Humans; D007564:Japan; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008297:Male; D011379:Prognosis; D013270:Stomach / Q000473:pathology / Q000601:surgery; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D000509:alpha-Fetoproteins