Synthesis of trehalose-based compounds and their inhibitory activities against Mycobacterium smegmatis.
The synthesis of a library of trehalose-based compounds has been accomplished, and their activities against Mycobacterium smegmatis have been determined. A preliminary structure-activity relationship (SAR) is reported. Despite not having a potent lead, one of the trehalose derivatives displays strong activity when applied with isoniazid (INH), which is known to have low sterilizing activity. The bacteriocidal nature of our compounds against Mycobacterium may be significant for the development of new therapies against tuberculosis.
Wang
Jinhua
J
Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA.
Elchert
Bryan
B
Hui
Yu
Y
Takemoto
Jon Y
JY
Bensaci
Mekki
M
Wennergren
John
J
Chang
Huiwen
H
Rai
Ravi
R
Chang
Cheng-Wei Tom
CW
D020650:Combinatorial Chemistry Techniques; D004305:Dose-Response Relationship, Drug; D007538:Isoniazid; D008826:Microbial Sensitivity Tests; D020102:Mycobacterium smegmatis / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014199:Trehalose / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D014199:Trehalose; D007538:Isoniazid