Peptide self-assembly as a model of proteins in the pre-genomic world.
Excellent catalytic efficiency has been obtained within a series of self replicating peptides, and nucleobase inclusion into a salt-switchable self replicating peptide is found to override the switch. Interestingly, cross-catalytic formation of an RNA aptamer is reported with a cationic peptide, and novel, amide-based biopolymers have been designed to self assemble.
Ghosh
Indraneel
I
Department of Chemistry, University of Arizona, 1306 E. University Blvd, Tuscon, AZ 85721, USA. ghosh@email.arizona.edu
Chmielewski
Jean
J
D000595:Amino Acid Sequence; D005075:Biological Evolution; D002384:Catalysis; D008956:Models, Chemical; D008969:Molecular Sequence Data; D000069497:Origin of Life; D010455:Peptides / Q000737:chemistry*; D014176:Protein Biosynthesis
D010455:Peptides