Xanthorrhizol has a potential to attenuate the high dose cisplatin-induced nephrotoxicity in mice.
Cisplatin is a widely used anticancer drug, but it can produce undesirable side effects such as nephrotoxicity. The present study investigated the effect of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. (Zingiberaceae) on cisplatin-induced nephrotoxicity in mice. A single dose of cisplatin (45 mg/kg, i.p.) significantly elevated the levels of blood urea nitrogen, serum creatinine, and the kidney to body weight ratio, but the pretreatment of xanthorrhizol (200 mg/kg/day, per os) for 4 days significantly attenuated the cisplatin-induced nephrotoxicity. The preventive effect of xanthorrhizol was more efficacious than that of curcumin with the same amount (200 mg/kg). However, this effect seemed not to be related with the ability of xanthorrhizol to regulate the DNA-binding activities of transcription factors such as nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1). This is first time the preventive effect of xanthorrhizol on cisplatin-induced nephrotoxicity has been demonstrated, and these data suggest that the administration of xanthorrhizol is a promising approach in the treatment of nephrotoxicity caused by cisplatin.
Kim
Seong Hwan
SH
Brain Korea 21 project for Medical Science, Yonsei University, 134 Shinchon-Dong, Seodaemun-Gu, Seoul 120-752, South Korea. kim_akh@hotmail.com
Hong
Kyoung Ok
KO
Hwang
Jae Kwan
JK
Park
Kwang-Kyun
KK
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001806:Blood Urea Nitrogen; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D003474:Curcumin / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology*; D011897:Random Allocation; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
D000970:Antineoplastic Agents; D010636:Phenols; D014157:Transcription Factors; C120248:xanthorrhizol; D008315:Malondialdehyde; D003404:Creatinine; D003474:Curcumin; D002945:Cisplatin