Epstein-Barr virus positivity in primary vaginal lymphoma.
BACKGROUND
Primary non-Hodgkin lymphoma (NHL) of the vagina is a rare location. Its association with the Epstein-Barr virus (EBV) has been only reported in another case. We present a new case, emphasizing the oncogenetic relevance of EBV.


METHODS
A 45-year-old woman with a pelvic pain revealed in her vaginal inspection a thick and hard vaginal plug with a "paving stone" appearance. The biopsy reported a vaginal non-Hodgkin lymphoma type B of intermediate cell, with positive result for EBV. After treatment, a complete remission was obtained.


CONCLUSIONS
The EBV is the main responsible for the non-Hodgkin lymphoma; classified as a group I carcinogen, it has been associated with a variety of neoplastic tumors, although it is unusual with extranodal type B diffuse lymphoma.
Domingo
S
S
Department of Obstetrics and Gynaecology, Hospital Universitario Dr. Peset, Avda. Gaspar Aguilar 90, Valencia 46017, Spain. Santiago.Domingo@ono.com
Perales
A
A
Torres
V
V
Alcaraz
M J
MJ
Pellicer
A
A
D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D016393:Lymphoma, B-Cell / Q000821:virology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000821:virology*; D008875:Middle Aged; D014625:Vaginal Neoplasms / Q000821:virology*