title: (2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga.
abstract: A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 mug/mL and against Candida glabrata with a MIC of 30 microg/mL.
authors.affiliation: Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil.
authors.forename: Miriam H
authors.initials: MH
authors.lastname: Kossuga
authors.forename: John B
authors.initials: JB
authors.lastname: MacMillan
authors.forename: Evan W
authors.initials: EW
authors.lastname: Rogers
authors.forename: Tadeusz F
authors.initials: TF
authors.lastname: Molinski
authors.forename: Gislene G F
authors.initials: GG
authors.lastname: Nascimento
authors.forename: Rosana M
authors.initials: RM
authors.lastname: Rocha
authors.forename: Roberto G S
authors.initials: RG
authors.lastname: Berlinck
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D002175:Candida / Q000187:drug effects*; D002942:Circular Dichroism; D007851:Dodecanol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D013237:Stereoisomerism; D014561:Urochordata / Q000737:chemistry*
chemical_list: C495165:2-aminododecan-3-ol; D000935:Antifungal Agents; D007851:Dodecanol