title: Prevalence of multiple sclerosis in a residential area bordering an oil refinery.
abstract: BACKGROUND
  Community concerns about a potential excess of multiple sclerosis (MS) prompted this study.
  
  
  OBJECTIVE
  To determine the period prevalence of MS in a community bordering a closed oil refinery and a control community.
  
  
  METHODS
  Cases seen by a neurologist during 1998 to 2001 were obtained from area neurologists and hospital discharge data. Population data were obtained from the year 2000 US Census. Patient data were abstracted by a trained abstractor onto a standardized report form. A consulting neurologist reviewed the form and made a final diagnosis using the Poser criteria plus the category of presumed. Age-adjusted prevalence rates and rates of agreement were calculated.
  
  
  RESULTS
  The direct age-adjusted period prevalence for both sexes and all races for the entire study area was 113 per 100,000 (95% CI = 93 to 136). For white subjects only, the prevalence was 123 per 100,000 (95% CI = 102 to 147). With use of an indirect method of age adjustment, the number of observed cases in the community bordering the refinery was similar to the number of cases expected (standardized morbidity ratio = 130.8, 95% CI = 62.3 to 199.3), based on rates from the comparison area. The agreement between the treating neurologist (for definite plus probable cases) and the consulting neurologist (for definite plus probable plus presumed cases) was good (kappa = 0.5733).
  
  
  CONCLUSIONS
  The prevalence of multiple sclerosis (MS) for this area was generally consistent with prevalence estimates calculated in previous studies in other areas. No significant excess was seen in the exposed area. MS was more prevalent in females than in males. The overall agreement between the consulting and treating neurologist was good.
authors.affiliation: Department of Preventive Medicine and Public Health, University of Kansas School of Medicine, Mail Stop 1008, 3901 Rainbow Blvd., Kansas City, KS 66160, USA. jneuberg@kumc.edu
authors.forename: J S
authors.initials: JS
authors.lastname: Neuberger
authors.forename: S G
authors.initials: SG
authors.lastname: Lynch
authors.forename: M L
authors.initials: ML
authors.lastname: Sutton
authors.forename: S B
authors.initials: SB
authors.lastname: Hall
authors.forename: C
authors.initials: C
authors.lastname: Feng
authors.forename: W R
authors.initials: WR
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D000368:Aged; D002617:Chemical Industry; D004781:Environmental Exposure; D005260:Female; D015386:Hazardous Substances; D006801:Humans; D008297:Male; D008875:Middle Aged; D008923:Missouri / Q000453:epidemiology; D009103:Multiple Sclerosis / Q000453:epidemiology*; D010578:Petroleum / Q000009:adverse effects*; D015995:Prevalence; D012989:Soil Pollutants / Q000009:adverse effects; D014874:Water Pollutants, Chemical / Q000009:adverse effects
chemical_list: D015386:Hazardous Substances; D010578:Petroleum; D012989:Soil Pollutants; D014874:Water Pollutants, Chemical