Nanomanipulation of extended single-DNA molecules on modified mica surfaces using the atomic force microscopy.
The technique of nanometer scale manipulation is very important in constructing nano-structures and nano-devices. By using atomic force microscope, three kinds of controllable manipulation on single-DNA molecules were introduced in the paper. DNA molecules deposited and extended on modified mica surface were first imaged by tapping mode, then cutting, bending, and pushing were respectively performed on single-DNA molecules. The results of the manipulation depend on the interaction between tip and DNA as well as between substrate and DNA.
Lü
Jun Hong
JH
Nanobiology and Nanomedicine Laboratory, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China. Junhonglv@hotmail.com
D000538:Aluminum Silicates / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure; D018625:Microscopy, Atomic Force / Q000379:methods; D036103:Nanotechnology
D000538:Aluminum Silicates; D004247:DNA; C011934:mica