title: Expanding the scope of C-H amination through catalyst design.
abstract: Analysis of the mechanism for Rh-mediated C-H amination has led to the development of a remarkably effective dinuclear Rh catalyst derived from 1,3-benzenedipropionic acid. This unique complex, Rh2(esp)2, is capable of promoting both intra- and intermolecular C-H oxidation reactions, and in all cases is superior to Rh2(O2CtBu)4. For the first time, C-H insertion is described with urea and sulfamide substrates to give 1,2- and 1,3-diamine derivatives, respectively. In addition, intermolecular amination of benzylic and secondary C-H bonds is shown to proceed efficiently even under conditions in which the starting alkane is employed as the limiting reagent.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
authors.forename: Christine G
authors.initials: CG
authors.lastname: Espino
authors.forename: Kristin Williams
authors.initials: KW
authors.lastname: Fiori
authors.forename: Mihyong
authors.initials: M
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Du Bois