[Analysis of expression of estrogen (ER) and progesterone receptors (PR) in brain glial tumors and its correlation with expression of p53 protein and proliferating cell nuclear antigen (PCNA)].
OBJECTIVE
All the types of the glial cells contain estrogen (ER) and progesterone receptors (PR) but their occurrence in glial tumors of the brain is still controversial. The aim of this research was the clinical analysis of ER and PR expression in correlation with histological malignancy and expression of p53 and PCNA.


METHODS
The investigation was carried out on a group of 56 patients operated on at the Neurosurgical Department of Wroclaw Medical University. The percentage of tumors containing ER and PR was assessed and mean receptor expressions were compared. Classical histological tests, immunohistochemical tests for ER, PR, p53 and PCNA with monoclonal antibodies (DACO) were performed for every specimen of tumor tissue.


RESULTS
ER occurred in 24 cases (42.9%), PR in 10 cases (17.9%). 49% of highly malignant gliomas (WHO III and IV) were ER positive, whereas 29% of tumors grade I and II were ER positive. Frequencies of PR positive tumors were similar in both groups. Mean PR expression in p53 positive group was 8% and in p53 negative group 1.5% (p=0.017). Mean ER expression in PCNA positive group was 7.4%, whereas in PCNA negative group 2.7% (p<0.01).


CONCLUSIONS
Frequency of ER occurrence is higher in highly malignant tumors. ER expression is correlated with proliferative activity (PCNA). PR expression is positively correlated with intensity of mutant p53 protein.
Berny
Władysław
W
Katedra i Klinika Neurochirurgii, Akademia Medyczna we Wrocławiu, Wrocław, Poland.
Weiser
Artur
A
Jarmundowicz
Włodzimierz
W
Markowska-Woyciechowska
Alicja
A
Załuski
Rafał
R
Zub
Wojciech
W
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D001932:Brain Neoplasms / Q000276:immunology / Q000378:metabolism*; D005260:Female; D005910:Glioma / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018809:Proliferating Cell Nuclear Antigen / Q000276:immunology / Q000378:metabolism*; D011959:Receptors, Estradiol / Q000276:immunology / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000276:immunology / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000276:immunology
D000911:Antibodies, Monoclonal; D018809:Proliferating Cell Nuclear Antigen; D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D016159:Tumor Suppressor Protein p53