Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase.
Digalactosyl and monogalactocyl diacylglycerols (DGDG and MGDG), which were identified as anti-hyperlipemia active components in Colocasia esculenta (Taro), were synthesized. The inhibitory activity of DGDG, MGDG and related compounds on human lanosterol synthase was evaluated as anti-hyperlipemic activity. DGDG with two myristoyl groups at both sn-1 and sn-2 positions and with an oleoyl group at the sn-1 position showed the most potent activity.
Tanaka
Rie
R
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-Ku, Tokyo 158-8501, Japan.
Sakano
Yuichi
Y
Nagatsu
Akito
A
Shibuya
Masaaki
M
Ebizuka
Yutaka
Y
Goda
Yukihiro
Y
D002240:Carbohydrate Sequence; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D038983:Galactolipids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D019751:Intramolecular Transferases / Q000037:antagonists & inhibitors*; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D038983:Galactolipids; C007388:digalactosyldiacylglycerol; D019751:Intramolecular Transferases; C021924:lanosterol synthase