[Value of transvaginal color Doppler flow imaging conjugated with multiple serum tumor markers in diagnosis of ovarian tumors].
OBJECTIVE
To investigate the value of trasvaginal color Doppler flow imaging (TV-CDFI ) in combination with multiple serum tumor markers in the diagnosis of ovarian tumors.


METHODS
A total of 74 patients with pelvic masses ( 30 cases with benign tumors, 44 cases with malignant tumors) were examined by TV-CDFI and the level of 7 serum tumor markers was also measured at same time. The above results were compared with the pathologic findings.


RESULTS
The diagnostic accuracy for the TV-CDFI only, and 7 serum tumor markers measured were 90.5% and 59.5% respectively. If TV-CDFI combined with multiple serum tumor marker measurements, the diagnostic accuracy of 98.6% was achieved, whereby it was 97.7% for malignant tumors.


CONCLUSIONS
TV-CDFI allows the diagnosis and differential diagnosis of the majority of ovarian tumors, particularly in part of ovarian carcinoma at early stage. Combined with multiple serum tumor marker measurements, this method can improve diagnostic sensitivity and specificity,hence it facilitates the early diagnosis and differential diagnosis.
Wang
Yue
Y
Department of Ultrasound, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060 P.R.China. gz-wangyue@yahoo.com.cn
Liu
Long-Zhong
LZ
Zhou
Jian-Hua
JH
Pei
Xiao-Qing
XQ
Chen
Xiao-Yue
XY
D000230:Adenocarcinoma / Q000097:blood / Q000000981:diagnostic imaging; D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018284:Cystadenocarcinoma, Serous / Q000097:blood / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000000981:diagnostic imaging*; D013724:Teratoma / Q000097:blood / Q000000981:diagnostic imaging*; D018615:Ultrasonography, Doppler, Color
D014408:Biomarkers, Tumor