title: Non-invasive detection of prostate cancer by electromagnetic interaction.
abstract: OBJECTIVE
  Malignant and normal tissues are known to have different electromagnetic properties, and various attempts have been made to use these information for diagnostic purposes. A nonlinear tuneable oscillator (Trimprob) generating extremely low energy multiple electromagnetic fields has been developed for non-invasive analysis of electromagnetic anisotropy in humans. Objective of this study was to evaluate the feasibility of prostate cancer detection using the TRIMprob and to evaluate its diagnostic accuracy.
  
  
  METHODS
  757 men were evaluated with the TRIMprob between July 2002 and May 2003 in a prostate unit. The TRIMprob was moved over the surface of the patient's perineum while standing, normally dressed, in front of the system receiver. A single operator, blinded to the patient status, conducted the tests. Nonlinear resonance was analysed at 465, 930 and 1395 MHz.
  
  
  RESULTS
  Analysis of resonance values at 465 MHz showed a significant difference between controls, patients with benign prostatic hyperplasia and patients with prostate cancer. In our study population, a sensitivity of 95.5% and specificity of 42.7% for the diagnosis of prostate cancer with a positive and negative predictive value of 63.6% and 89.8% was found.
  
  
  CONCLUSIONS
  The results of this study confirm the possibility of electromagnetic detection of cancer. An extracorporeal scan by the TRIMprob can identify patients at risk for prostate cancer, and recognise those in whom the risk is extremely low. The results of the present study represent a proof-of-concept, which may open a new field of medicine.
authors.affiliation: Department of Urology, S. Carlo Borromeo Hospital, Milan, Italy. carlo.bellorofonte@fastwebnet.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Bellorofonte
authors.forename: Clarbruno
authors.initials: C
authors.lastname: Vedruccio
authors.forename: Pietro
authors.initials: P
authors.lastname: Tombolini
authors.forename: Michele
authors.initials: M
authors.lastname: Ruoppolo
authors.forename: Andrea
authors.initials: A
authors.lastname: Tubaro
mesh_terms: D055590:Electromagnetic Phenomena / Q000295:instrumentation; D004867:Equipment Design; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis*