Productive RUPture: activation of transcription factors by proteasomal processing.
Proteasomes usually degrade proteins completely into small peptides. In a few cases, however, proteasomal degradation rather results in protein processing, thereby yielding proteins of different biological activity. This process, termed "regulated ubiquitin/proteasome-dependent processing" or RUP, is essential for the function of certain transcription factors and crucial for their regulation. Examples are proteins of the mammalian NF-kappaB family and the yeast proteins SPT23 and MGA2. In this review, we summarize the available data and suggest a mechanistic model for proteasomal processing.
Rape
Michael
M
Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Jentsch
Stefan
S
D000818:Animals; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000502:physiology*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D025801:Ubiquitin / Q000502:physiology*
D014157:Transcription Factors; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex