Farinosones A-C, neurotrophic alkaloidal metabolites from the entomogenous deuteromycete Paecilomyces farinosus.
Two new yellow pigments, farinosones A (1) and B (2), were isolated from the mycelial extract of the entomogenous fungal strain Paecilomyces farinosus RCEF 0101, together with farinosone C (3), a new metabolite derived from an early step of pyridone alkaloid biosynthesis. The structures were determined by spectroscopic means, in particular by extensive NMR experiments. Compounds 1 and 3 induced neurite outgrowth in the PC-12 cell line at concentrations of 50 microM, while compound 2 was inactive. No cytotoxicity was observed for compounds 1-3 in PC-12 cells when tested at 50 microM concentration in the MTT assay.
Cheng
Yongxian
Y
Institute of Pharmacy, Friedrich-Schiller-University Jena, Semmelweisstrasse 10, D-07743 Jena, Germany.
Schneider
Bernd
B
Riese
Ulrike
U
Schubert
Barbara
B
Li
Zengzhi
Z
Hamburger
Matthias
M
D000818:Animals; D002681:China; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D010143:Paecilomyces / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
D009414:Nerve Growth Factors; D010636:Phenols; D010860:Pigments, Biological; D011728:Pyridones; C495160:farinosone A; C495161:farinosone B; C495162:farinosone C