title: [Evaluation of the reactogenicity and immunogenic potency of combined vaccine "Bubo-Kok" in the immunization of children against diphtheria, tetanus, pertussis and viral hepatitis B].
abstract: Combined vaccine "Bubo-Kok" is characterized by safety and high immunological activity. The number of postvaccinal reactions in children aged 1 and 2 years, immunized with vaccine "Bubo-Kok", was not statistically different from those in groups of children immunized with adsorbed DPT vaccine, as well with such vaccine in combination with vaccine against hepatitis B. After the completion of the primary course of immunization 100% of children had protective antibody titers against diphtheria, tetanus and hepatitis B. Antibody titers against pertussis, equal to or exceeding protective titers, were found in more than 70% of immunized children. The immunogenic potency of vaccine "Bubo-Kok" with respect to all its components was not inferior to that of adsorbed DPT vaccine and vaccine against hepatitis B, when introduced simultaneously in different areas of the body. Vaccine "Bubo-Kok" successfully passed state trials and was recommended for registration.
authors.forename: I V
authors.initials: IV
authors.lastname: Fel'dblium
authors.forename: A M
authors.initials: AM
authors.lastname: Nikolaeva
authors.forename: A V
authors.initials: AV
authors.lastname: Kuz'ianin
authors.forename: V N
authors.initials: VN
authors.lastname: Borisova
authors.forename: V A
authors.initials: VA
authors.lastname: Mel'nikov
authors.forename: R P
authors.initials: RP
authors.lastname: Chuprinina
authors.forename: O V
authors.initials: OV
authors.lastname: Perelygina
authors.forename: N V
authors.initials: NV
authors.lastname: Shalunova
authors.forename: V D
authors.initials: VD
authors.lastname: Semenova
authors.forename: D V
authors.initials: DV
authors.lastname: Griaznova
authors.forename: E V
authors.initials: EV
authors.lastname: Pushkareva
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Uvitskiĭ
authors.forename: I A
authors.initials: IA
authors.lastname: Alekseeva
authors.forename: O A
authors.initials: OA
authors.lastname: Konopleva
authors.forename: M V
authors.initials: MV
authors.lastname: Budanov
authors.forename: I M
authors.initials: IM
authors.lastname: Iakovleva
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D001886:Bordetella pertussis / Q000276:immunology; D002675:Child, Preschool; D003017:Clostridium tetani / Q000276:immunology; D003353:Corynebacterium diphtheriae / Q000276:immunology; D004165:Diphtheria / Q000517:prevention & control*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D013742:Tetanus / Q000517:prevention & control*; D014611:Vaccination; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology; D014917:Whooping Cough / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D017778:Vaccines, Combined