title: Biological activities of pyridoacridines.
abstract: This review consolidates biological activity data reported for pyridoacridine 1 molecules in the literature from 1983-2003 into several tables with brief discussions of assays used and results obtained. This review summarizes recent progress in structure activity relationships for analogues of amphimedine 2 and ascididemin 3 classes of pyridoacridines and correlates reported molecular mechanisms of action with biological activities.
authors.affiliation: Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Marshall
authors.forename: Louis R
authors.initials: LR
authors.lastname: Barrows
mesh_terms: D000166:Acridines / Q000737:chemistry / Q000494:pharmacology*; D000470:Alkaloids / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D000977:Antiparasitic Agents / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D010618:Phenanthrolines / Q000737:chemistry / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology
chemical_list: D000166:Acridines; D000470:Alkaloids; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000977:Antiparasitic Agents; D000998:Antiviral Agents; D010618:Phenanthrolines; D011804:Quinolines; C475900:pyridoacridine; C412046:ascididemin; C475901:amphimedine; D004247:DNA