Potential candidates for cardiac resynchronization therapy in Japanese patients with idiopathic dilated cardiomyopathy--a Niigata multicenter study of DCM--.
BACKGROUND
The purpose of this study was to assess the candidates suitable for cardiac resynchronization therapy (CRT) and to examine the significance of the QRS duration in Japanese patients with idiopathic dilated cardiomyopathy (DCM).


RESULTS
The study population consisted of 357 patients. The selection criteria for candidates suitable for CRT were QRS duration =130 ms, left ventricular ejection fraction (LVEF) =35% and New York Heart Association (NYHA) functional class III or IV by ACC/AHA/NASPE 2002 guidelines. We divided the study population into 2 groups: group A with a QRS duration <130 ms, and group B with a QRS duration =130 ms. In 25 of the 375 patients (7.0%), all the criteria were fulfilled. Group B had a significantly larger left ventricular diameter end-diastole and end-systole than group A (P<0.0001). Group B had a lower LVEF (P<0.0001). There was a fair inverse correlation (r=-0.58, P<0.0001) between the length of the QRS duration and LVEF.


CONCLUSIONS
Approximately 7% of the Japanese patients with DCM are CRT candidates. In the present study, we found that prolonged QRS duration was associated with poor systolic function.
Komura
Satoru
S
First Department of Internal Medicine, Division of Cardiology, Niigata University School of Medicine, Asahimachi, Niigata, Japan. k1satoru@sweet.ocn.ne.jp
Chinushi
Masaomi
M
Kudo
Michiko
M
Saikawa
Takashi
T
Tanabe
Yasutaka
Y
Furushima
Hiroshi
H
Washizuka
Takashi
T
Kodama
Makoto
M
Oda
Hirotaka
H
Miyajima
Seiichi
S
Masani
Fumiaki
F
Igarashi
Yutaka
Y
Murata
Minoru
M
Aizawa
Yoshifusa
Y
D000368:Aged; D002304:Cardiac Pacing, Artificial; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D013318:Stroke Volume; D013997:Time Factors