Urate oxidation in CSF and blood of patients with inflammatory disorders of the nervous system.
Urate is largely excluded from the brain under non-inflammatory conditions (concentration gradient serum:CSF about 10:1), but increases markedly in Guillain-Barré Syndrome and bacterial meningitis. The oxidation product allantoin is normally not passively distributed between blood and cerebrospinal fluid (gradient 3:1) and increases 5-fold in CSF of patients with meningitis. Patients with multiple sclerosis had normal levels of urate and allantoin in blood and CSF.
Becker
B F
BF
Department of Physiology, University of Munich, Munich, Germany.
Kastenbauer
S
S
Ködel
U
U
Kiesl
D
D
Pfister
H W
HW
D000481:Allantoin / Q000378:metabolism; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000473:pathology*; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D007249:Inflammation / Q000134:cerebrospinal fluid*; D008581:Meningitis / Q000097:blood / Q000134:cerebrospinal fluid; D016920:Meningitis, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid; D010100:Oxygen / Q000378:metabolism*; D014527:Uric Acid / Q000378:metabolism*
D014527:Uric Acid; D000481:Allantoin; D010100:Oxygen