Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia.
A case of de novo acute myeloblastic leukemia (AML) M2, with trisomy 4 and double minute (dmin) chromosomes is reported. Amplification of the MYC gene ascertained by FISH was associated with dmin. A review of the literature of trisomy 4-dmin-associated AML shows that this entity preferentially occurs in elderly women and is not always associated with previously identified exposition to mutagens.
Receveur
Aline
A
Groupe Hospitalier Pitié-Salpêtrière, Service d'Hématologie Biologique, Paris, France.
Ong
Jeanne
J
Merlin
Laurent
L
Azgui
Zahia
Z
Merle-Béral
Hélène
H
Berger
Roland
R
Nguyen-Khac
Florence
F
D000367:Age Factors; D000368:Aged; D001247:Asthenia; D002894:Chromosomes, Human, Pair 4; D005260:Female; D005784:Gene Amplification; D016259:Genes, myc; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D012737:Sex Factors; D014314:Trisomy / Q000235:genetics*