title: The pathophysiology of hyperuricemia in essential hypertension: a pilot study.
abstract: We have examined whether hyperuricemia in essential hypertension may be related to an increased insulin secretion thereby enhancing the tubular reabsorption of sodium and thus uric acid. Insulin hypersecretion, as elicited by the oral glucose tolerance test (OGTT), increased a mean of 5-fold in 12 essential hypertensive patients. Urinary uric acid to creatinine ratio significantly diminished by a mean of 62% after the OGTT. Simultaneously, urinary sodium to creatinine ratio decreased by a mean of 54%. These results suggest that insulin may mediate uric acid underexcretion due to its tubular sodium retaining effect in essential hypertensive patients.
authors.affiliation: Division of Internal Medicine, Hospital La Paz, Madrid, Spain.
authors.forename: Juan G
authors.initials: JG
authors.lastname: Puig
authors.forename: Rosa J
authors.initials: RJ
authors.lastname: Torres
authors.forename: Luis M
authors.initials: LM
authors.lastname: Ruilope
authors.forename: C
authors.initials: C
authors.lastname: Campo
authors.forename: Cristina
authors.initials: C
authors.lastname: Grande
authors.forename: Teresa
authors.initials: T
authors.lastname: Sancho
authors.forename: José I
authors.initials: JI
authors.lastname: Bernardino
mesh_terms: D000328:Adult; D000368:Aged; D003404:Creatinine / Q000652:urine; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D033461:Hyperuricemia / Q000150:complications / Q000503:physiopathology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008875:Middle Aged; D010865:Pilot Projects; D012964:Sodium / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism / Q000652:urine
chemical_list: D007328:Insulin; D014527:Uric Acid; D012964:Sodium; D003404:Creatinine