title: [Pharmacokinetics of m-nifedipine in Beagle dogs].
abstract: OBJECTIVE
  To study the pharmacokinetics of m-nifedipine (m-Nif) in Beagle dogs.
  
  
  METHODS
  The Beagle dogs were divided into two groups. m-Nif was intravenously administered to the Beagle dogs in group 1 at the dose of 0. 288 mg x kg(-1), and it was orally administered to the Beagle dogs in group 2, 3 and 4 at the dose of 1.152, 3.456 and 10.370 mg x kg(-1), respectively. m-Nif in plasma was detected by reversed phase high performance liquid chromatography. The pharmacokinetic parameters were calculated by 3P97 software.
  
  
  RESULTS
  When m-Nif was intravenously administered, the plasma concentration-time curve was fit to a two-compartment model and T1/2beta was 117 min. When m-Nif was orally administered, the plasma concentration-time curve was fit to a one-compartment model. T1/2 (Ke) and Cmax were 147 min and 20 microg x L(-1); at the low dose of 1.152 mg x kg(-1). T1/2 (Ke) was 122 min and Cmax was 36 microg x L(-1) at the middle dose of 3.456 mg x kg(-1). T1/2 (Ke) was 144 min and Cmax was 69 microg x L(-1) at the high dose of 10.37 mg x kg(-1), respectively.
  
  
  CONCLUSIONS
  It was showed that the speed of elimination of m-Nif was high in Beagle dogs. The absolute bioavailability of m-Nif given orally was very low.
authors.affiliation: Department of Pharmacology, The Fourth Military Medical University, Xi'an 710032, China. yang_zf@hotmail.com
authors.forename: Zhi-fu
authors.initials: ZF
authors.lastname: Yang
authors.forename: Si-yuan
authors.initials: SY
authors.lastname: Zhou
authors.forename: Tie-hong
authors.initials: TH
authors.lastname: Yang
authors.forename: Qi-bing
authors.initials: QB
authors.lastname: Mei
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004285:Dogs; D007275:Injections, Intravenous; D007536:Isomerism; D009543:Nifedipine / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D002121:Calcium Channel Blockers; D009543:Nifedipine