title: Risk factors and mortality associated with Clostridium difficile-associated diarrhoea at a VA hospital.
abstract: The objective of this study was to evaluate the risk of certain patient co-morbidities and antibiotics in the development of Clostridium difficile-associated diarrhoea (CDAD). Hospitalized patients developing CDAD during a specified period were compared with a cohort of patients, matched by age, without a diagnosis of CDAD, who were hospitalized during the same time period. Data collection included demographics, hospital ward, co-morbid conditions, antibiotics received, and mortality. Gender and age were similar in both groups. Co-morbid conditions significantly associated with the case group included cancer and COPD. The most commonly prescribed antibiotics in the case versus control group included levofloxacin, intravenous vancomycin, clindamycin, and piperacillin/tazobactam. The case group was associated with a higher mortality rate.
authors.affiliation: Pharmacy Services, Edward Hines Jr. VA Hospital, Fifth Avenue and Roosevelt Road, Building 200, Room 1243, Hines, IL 60141, USA.
authors.forename: Ursula
authors.initials: U
authors.lastname: Changela
authors.forename: Joan P
authors.initials: JP
authors.lastname: Cannon
authors.forename: Chinyere
authors.initials: C
authors.lastname: Aneziokoro
authors.forename: Palak S
authors.initials: PS
authors.lastname: Shah
authors.forename: Lizy
authors.initials: L
authors.lastname: Thottapurathu
authors.forename: Joseph
authors.initials: J
authors.lastname: Lentino
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents; D016022:Case-Control Studies; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality*; D003428:Cross Infection / Q000209:etiology; D003967:Diarrhea / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality*; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006760:Hospitalization; D006787:Hospitals, Veterans; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents