Low-grade endometrial stromal sarcoma treated with the aromatase inhibitor letrozole.
BACKGROUND
Low-grade endometrial stromal sarcoma is an indolent steroid responsive tumor. Successful hormonal treatment, most commonly with megestrol acetate, has been reported.


METHODS
A 76-year-old woman underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy 25 years earlier allegedly for a benign condition. She presented to us with postrenal kidney failure and a huge pelvic mass compressing both ureters. After transvaginal trough-cut biopsy of the mass, the diagnosis of low-grade endometrial stromal sarcoma with a high expression of alpha-estrogen receptor was made. The patient was treated with letrozole only with a spectacular response.


CONCLUSIONS
To the best of our knowledge, this is the first case for which letrozole was used on long-term basis as first-line hormonal treatment for a recurrent low-grade stromal sarcoma.
Leunen
M
M
Department of Gynecology, Andrology and Obstetrics, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium. michele.leunen@az.vub.ac.be
Breugelmans
M
M
De Sutter
Ph
P
Bourgain
C
C
Amy
J J
JJ
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D000077289:Letrozole; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D009570:Nitriles / Q000627:therapeutic use*; D018203:Sarcoma, Endometrial Stromal / Q000188:drug therapy* / Q000473:pathology; D014230:Triazoles / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole