[Effect of combined continued hormone replacement therapy on knee osteoarthritis symptom of postmenopausal women].
OBJECTIVE
To study the effect of combined continued estrogen and progestin replacement therapy on knee osteoarthritis (OA) symptoms of postmenopausal women.


METHODS
Sixty-four postmenopausal women with radiological knee OA and symptoms aged 45-75 were divided into treatment group and control group. They were given estradiol velerate (E2V) 1.0 mg/d and medroxyprogestetone acetate (MPA) 2 mg/d (treatment group) or placebo (control group) for 6 months. Calcium 400 mg/d were given to all cases. Then 0-100 mm visual analon scale (VAS) was used to evaluate the severity of knee pain at baseline and after 1, 3, 6 month of treatment.


RESULTS
Significant differences on pain at night and tenderness around knee were seen in the treatment group compared with the control group after 1 months of treatment (P = 0.036 and 0.035, respectively). The improvement of pain at night, during walk and morning stiffness between the two groups showed significant difference after 6 months (P = 0.026, 0.027, and 0.011, respectively).


CONCLUSIONS
Combined estrogen and progestin replacement therapy can relieve the knee OA symptoms of postmenopausal women.
Song
Yi-jun
YJ
Department of Obstetrics and Gynecology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. sunny_syj@yahoo.com.cn
Lin
Shou-qing
SQ
Wu
Zhi-hong
ZH
Weng
Xi-sheng
XS
Qiu
Gui-xing
GX
Chen
Feng-ling
FL
D000368:Aged; D004311:Double-Blind Method; D004958:Estradiol / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy*; D017698:Postmenopause; D011446:Prospective Studies
D004958:Estradiol; D017258:Medroxyprogesterone Acetate