Serum nutrient markers and skin prick testing using data from the Third National Health and Nutrition Examination Survey.
BACKGROUND
Diet nutrients and allergic sensitization both affect the development and severity of asthma, but the interrelationship between oral intake and allergic sensitization is not well characterized, although previous work suggests that a higher vitamin E intake may be protective against allergic sensitization.


OBJECTIVE
To determine whether serum levels of dietary antioxidants, lipids, and other nutrients are associated with the presence of allergen skin sensitization.


METHODS
Cross-sectional logistic regression analysis of 30 serum nutrient levels in relation to 10 skin test allergens in adults and children in the Third National Health and Nutrition Survey.


RESULTS
In adults, allergic skin sensitization was less common in participants with higher serum levels of vitamin E: the adjusted odds ratio (OR) per SD difference in vitamin E level was 0.93 (95% CI, 0.87-0.99). Two of the carotenoids, beta-cryptoxanthin and alpha-carotene, were also inversely associated with allergic skin sensitization (OR, 0.89; 95% CI, 0.83-0.95; and OR, 0.95; 95% CI, 0.91-0.99, respectively). Among adults, serum lycopene had a positive association with allergen sensitization. In youths, however, vitamin A was associated with an increased risk, and high-density lipoprotein cholesterol was associated with a decreased risk of allergic sensitization. The use of vitamin or mineral supplements had little effect on the magnitude of all reported associations.


CONCLUSIONS
Overall, there were no strong or consistent associations between serum levels of potentially antiallergic nutrients, and the occurrence of allergic skin sensitization in these data. However limited, findings suggest that increases in vitamin E, carotenoids, and high-density lipoprotein cholesterol may reduce the risk of allergic skin sensitization.
McKeever
Tricia M
TM
National Institute of Allergies and Infectious Diseaases, NIH, Bethesda, MD 20892, USA. Tricia.McKeever@nottingham.ac.uk
Lewis
Sarah A
SA
Smit
Henriette
H
Burney
Peter
P
Britton
John
J
Cassano
Patricia A
PA
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D002338:Carotenoids / Q000097:blood; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D006801:Humans; D008055:Lipids / Q000097:blood*; D016015:Logistic Models; D008875:Middle Aged; D008903:Minerals / Q000097:blood*; D012882:Skin Tests; D014815:Vitamins / Q000097:blood*
D000485:Allergens; D008076:Cholesterol, HDL; D008055:Lipids; D008903:Minerals; D014815:Vitamins; D002338:Carotenoids