[Proteinkinase MAK-V/Hunk as a possible dianostic and prognostic marker of human breast carcinoma].
We propose a system for detection of overproduction of protein kinase MAK-V/Hunk in tumours. MAK-V/ Hunk overproduction is observed in about 50% breast carcinomas. Positive staining is obseved in tumour cells only and has mainly cytoplasmic characteristics. Increased production of MAK-V/Hunk does not correlate with histological type of carcinoma, metastasizing, steroid receptor status (estrogen and progesterone), proliferative activity. Tumours positive for MAK-V/ Hunk were more frequently observed in c-erbB2-positive (3+) tumours than in c-erbB2-negative ones. Overproduction of MAK-V/Hunk in human breast cancer may be used fore more precise molecular typing of this tumour, in particular in case of c-erbB2-positive tumors, however, diagnostic-prognostic value of this new molecular marker needs further studies.
Korobko
I V
IV
Zavalishina
L E
LE
Kiselev
S L
SL
Raĭkhlin
N T
NT
Frank
G A
GA
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D011494:Protein Kinases / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism
D014408:Biomarkers, Tumor; D011494:Protein Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen