title: High molecular weight form insulin-like growth factor II-producing mesenteric sarcoma causing hypoglycemia.
abstract: An 81-year-old woman presented with frequent episodes of hypoglycemia. Her serum level of insulin was normal, but her serum insulin-like growth factor (IGF)-II level was high. She was found to have a spindle cell sarcoma originated from the mesentery of the sigmoid colon, which was completely resected. Postoperatively, hypoglycemia ameliorated with concomitant reduction in serum IGF-II levels. Immunohistochemical study revealed positive immunostaining for IGF-II in tumor cells, and the abundant expression of IGF-II mRNA was demonstrated by RT-PCR. The presence of high molecular weight (HMW) form IGF-II in patient's serum was confirmed by immunoblotting. This is the first report of a patient with HMW form IGF-II-producing mesenteric sarcoma causing hypoglycemia.
authors.affiliation: Division of Internal Medicine and Surgery, Tokyo Metropolitan Fuchu Hospital, Tokyo.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Sato
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Tsujino
authors.forename: Kenji
authors.initials: K
authors.lastname: Nishida
authors.forename: Yasukazu
authors.initials: Y
authors.lastname: Otani
authors.forename: Tomohito
authors.initials: T
authors.lastname: Minami
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Shichiri
authors.forename: Naomi
authors.initials: N
authors.lastname: Hizuka
authors.forename: Motohiko
authors.initials: M
authors.lastname: Aiba
authors.forename: Yukio
authors.initials: Y
authors.lastname: Hitara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007150:Immunohistochemistry; D007335:Insulin-Like Growth Factor II / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D008643:Mesentery / Q000473:pathology*; D008970:Molecular Weight; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012509:Sarcoma / Q000150:complications* / Q000556:secondary / Q000601:surgery; D012811:Sigmoid Neoplasms / Q000473:pathology
chemical_list: D012333:RNA, Messenger; D007335:Insulin-Like Growth Factor II