Regulation of growth signalling and cell cycle by Kaposi's sarcoma-associated herpesvirus genes.
Kaposi's sarcoma-associated herpesvirus (KSHV) is the primary aetiological agent of at least three malignancies associated with HIV infection and immunosuppression: Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease. KSHV encodes proteins that deregulate key checkpoints in the signalling pathways governing cell proliferation, which may ultimately contribute to the virus' oncogenic potential. To alter cellular signalling associated with proliferation, these viral proteins function like growth factor ligands/receptors, signal transduction proteins, transcription factors and cell cycle regulators. This review focuses on the mechanisms by which some KSHV-encoded proteins activate signalling pathways and cell proliferation and their role in the pathogenesis of KSHV-driven mechanisms.
Direkze
Shamindra
S
Cancer Research UK, Viral Oncology Laboratory, Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
Laman
Heike
H
D002453:Cell Cycle / Q000235:genetics*; D049109:Cell Proliferation; D015967:Gene Expression Regulation, Viral / Q000235:genetics; D005814:Genes, Viral / Q000235:genetics; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D017978:Receptors, Growth Factor / Q000235:genetics; D012514:Sarcoma, Kaposi / Q000235:genetics / Q000821:virology; D015398:Signal Transduction / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics*; D054334:Viral Regulatory and Accessory Proteins / Q000235:genetics
D017978:Receptors, Growth Factor; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins