Peptide nucleic acids with a flexible secondary amine in the backbone maintain oligonucleotide binding affinity.
[structure: see text] Replacing a secondary amide in a peptide nucleic acid backbone with a more flexible secondary amine affords an oligomer that surprisingly maintains the same binding affinity to complementary oligonucleotides as the unmodified polyamide oligomer.
Myers
Michael C
MC
Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA.
Pokorski
Jonathan K
JK
Appella
Daniel H
DH
D000588:Amines / Q000737:chemistry*; D018076:DNA, Complementary / Q000378:metabolism*; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D018075:RNA, Complementary / Q000378:metabolism*; D013696:Temperature
D000588:Amines; D018076:DNA, Complementary; D020135:Peptide Nucleic Acids; D018075:RNA, Complementary