title: Pharmacokinetics of telithromycin in plasma and soft tissues after single-dose administration to healthy volunteers.
abstract: By use of microdialysis we assessed the concentrations of telithromycin in muscle and adipose tissue to test its ability to penetrate soft tissues. The ratios of the area under the concentration-versus-time curve from 0 to 24 h to the MIC indicated that free concentrations of telithromycin in tissue and plasma might be effective against Streptococcus pyogenes but not against staphylococci and human and animal bite pathogens.
authors.affiliation: Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Medical University of Vienna, Vienna, Austria.
authors.forename: Rainer
authors.initials: R
authors.lastname: Gattringer
authors.forename: Eleonora
authors.initials: E
authors.lastname: Urbauer
authors.forename: Friederike
authors.initials: F
authors.lastname: Traunmüller
authors.forename: Markus
authors.initials: M
authors.lastname: Zeitlinger
authors.forename: Pejman
authors.initials: P
authors.lastname: Dehghanyar
authors.forename: Petra
authors.initials: P
authors.lastname: Zeleny
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Graninger
authors.forename: Markus
authors.initials: M
authors.lastname: Müller
authors.forename: Christian
authors.initials: C
authors.lastname: Joukhadar
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001798:Blood Proteins / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D006801:Humans; D007202:Indicators and Reagents; D048628:Ketolides / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D017551:Microdialysis; D018482:Muscle, Skeletal / Q000378:metabolism; D011485:Protein Binding; D012015:Reference Standards; D012867:Skin / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D007202:Indicators and Reagents; D048628:Ketolides; C106791:telithromycin