133Xe for the in vivo X-ray fluorescence measurement of platinum.
In vivo measurements of platinum are important for studying the pharmacokinetics of platinum-based cytotoxic drugs. The technique of in vivo X-ray fluorescence can be utilized for such measurements. The feasibility of using 133Xe in near-backscatter (almost 180 degrees ) geometry has been investigated and results compared to phantom measurements made using 99Tcm in the same experimental set-up. An improvement in minimum detection limits is observed for all phantom depths less than 25 mm.
Ogg
C A
CA
Department of Medical Physics and Clinical Engineering, Singleton Hospital, Swansea SA2 8QA, UK.
Ali
P A
PA
El-Sharkawi
A M
AM
Hancock
D A
DA
D005240:Feasibility Studies; D005453:Fluorescence; D006801:Humans; D019047:Phantoms, Imaging; D010984:Platinum / Q000493:pharmacokinetics*; D013052:Spectrometry, X-Ray Emission / Q000379:methods*; D014965:X-Rays; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D010984:Platinum