[Determining serum concentrations of the modern antipsychotic quetiapin: clinical relevance in therapeutic drug monitoring].
OBJECTIVE
The results concerning therapeutic drug monitoring of Quetiapin concentration in 152 in-patients will be presented.


METHODS
In addition to measuring the serum concentration of Quetiapin standardized patient data were collected and the clinical history assessed by the Brief Psychiatric Rating Scale (BPRS).


RESULTS
A significant positive correlation of the serum concentration and the daily dosage was found. Co-medication with the CYP 3A4 inhibitor Nefazodon was associated with an increase in the serum concentration without any adverse interactions occurring.


CONCLUSIONS
While a correlation of dosage and effect could be shown with Quetiapin, inter- and intraindividual differences could be observed. Drug monitoring therefore seems useful in clinical setting and is recommended.
Köhnlein
Oliver
O
Bezirkskrankenhaus Augsburg. oliver.koehnlein@bkh-augsburg.de
Lutz
Rita
R
Schmauss
Max
M
Messer
Thomas
T
D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D010054:Brief Psychiatric Rating Scale; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D003987:Dibenzothiazepines / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines; D011618:Psychotic Disorders / Q000097:blood* / Q000188:drug therapy; D000069348:Quetiapine Fumarate; D013223:Statistics as Topic; D014230:Triazoles / Q000008:administration & dosage / Q000009:adverse effects
D014150:Antipsychotic Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D003987:Dibenzothiazepines; D010879:Piperazines; D014230:Triazoles; D000069348:Quetiapine Fumarate; C051752:nefazodone; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A