Synthesis and in vitro cytotoxicity of- 1,3-dioxoindan-2-carboxylic acid arylamides.
A series of 1,3-dioxoindan-2-carboxylic acid arylamides were synthesized and evaluated for in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T-47D). The most active was compound 3e (1.2 microM against SK-OV-3 cell line) bearing a 4-methyl substituent.
Jung
Jae-Kyung
JK
College of Pharmacy, Chungbuk National University, Cheongju, 361-763, Korea.
Ryu
Jinhyeong
J
Yang
Sung-Il
SI
Cho
Jungsook
J
Lee
Heesoon
H
D000577:Amides / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000577:Amides; D000970:Antineoplastic Agents; D007189:Indans