title: Morbidity and mortality associated with pharmacotherapy. Evolution and current concept of drug-related problems.
abstract: Medicines are a great contribution to the rising life expectancy in XX century. But a lot of drug safety problems were reported since 1960's. More recently, ineffectiveness is also being considered as a problem. Since 1975, the term 'drug-related problem' (DRP) is being used for several definition and purposes. This has led to a number of different DRP classifications. The aim of the present review is to gather different positions, definitions and classifications of DRP. And to present a more modern concept, which is also named as pharmacotherapy failure, corresponding to negative clinical outcomes resulting from the use or the lack of use of medicines. Those pharmacotherapy failures include necessity, effectiveness and safety problems.
authors.affiliation: Research Group on Pharmaceutical Care, University of Granada, Spain. f_llimos@medynet.com
authors.forename: F
authors.initials: F
authors.lastname: Fernández-Llimós
authors.forename: L
authors.initials: L
authors.lastname: Tuneu
authors.forename: M I
authors.initials: MI
authors.lastname: Baena
authors.forename: A
authors.initials: A
authors.lastname: Garcia-Delgado
authors.forename: M J
authors.initials: MJ
authors.lastname: Faus
mesh_terms: D004358:Drug Therapy / Q000145:classification / Q000401:mortality*; D064420:Drug-Related Side Effects and Adverse Reactions; D015991:Epidemiologic Measurements; D006801:Humans; D008508:Medication Errors / Q000145:classification / Q000706:statistics & numerical data; D009017:Morbidity / Q000639:trends*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000145:classification; D013030:Spain; D017211:Treatment Failure
chemical_list: D004364:Pharmaceutical Preparations