title: Regulation of dendritic growth by calcium and neurotrophin signaling.
abstract: The development of cortical dendrites is regulated by both activity-dependent and activity-independent signaling. Activity-dependent dendritic growth involves calcium-dependent gene expression. Both CREB and CREST are transactivators that contribute to calcium-dependent dendritic growth. Dendritic development is also regulated by extracellular factors such as neurotrophins. Neurotrophin-dependent dendritic growth is mediated by the MAP kinase and PI 3-kinase pathways. Selective responsiveness to activity cues and neurotrophins may contribute to morphological diversity in the nervous system.
authors.affiliation: Amsterdam Molecular Therapeutics, Amsterdam, The Netherlands.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Dijkhuizen
authors.forename: Anirvan
authors.initials: A
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D003712:Dendrites / Q000502:physiology*; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D009414:Nerve Growth Factors