[Association between the expression of estrogen receptor subunit in endometrial carcinoma and the prognostic factors of endometrial carcinoma].
OBJECTIVE
To study the relationship between the expression of ERalpha and ERbeta mRNA in the fresh tissue from patients with endometrial carcinoma and to evaluate the association between the ratio of ERalpha/ERbeta and the prognostic factors of endometrial carcinoma.


METHODS
Multiplex RT-PCR was used to study the expression of ERalpha and ERbeta mRNA in the fresh endometrial tissue from 41 cases of endometrial carcinoma. The association between the expression of ERalpha/ERbeta mRNA and the prognostic factors of endometrial carcinoma was evaluated.


RESULTS
ERalpha mRNA and ERbeta mRNA were detected in 95% and 90.2% of the 41 cases of endometrial carcinoma, respectively. ERalpha/ERbeta > 1 was detected in 21 cases and ERalpha/ERbeta < 1 was detected in 14 cases. Analysis revealed an association between the ratio of ERalpha/ERbeta mRNA and the prognostic factors of endometrial carcinoma.


CONCLUSIONS
In this study, ERalpha mRNA overexpression (ERalpha/ERbeta > 1) was found associated with good prognostic factors of endometrial carcinoma, whereas ERbeta mRNA overexpression (ERalpha/ERbeta < 1) was found associated with poor prognostic factors of endometrial carcinoma.
Zhang
Jia-wen
JW
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Peng
Zhi-lan
ZL
D000230:Adenocarcinoma / Q000737:chemistry* / Q000235:genetics; D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000235:genetics; D004717:Endometrium / Q000737:chemistry; D047628:Estrogen Receptor alpha / Q000032:analysis* / Q000235:genetics; D047629:Estrogen Receptor beta / Q000032:analysis* / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D012333:RNA, Messenger