title: Management of leishmanial osteolytic lesions in a hypothyroid dog by partial tarsal arthrodesis.
abstract: A five-year-old male boxer, previously diagnosed with leishmaniasis and hypothyroidism, had gradually become unable to bear weight on its left hindlimb. Physical examination revealed a left popliteal lymphadenopathy, mild crepitus, and severe swelling of the left tarsal joint, a radiographic examination of which revealed severe bone destruction of the talus and a periosteal reaction of the calcaneus. Laboratory findings and serological tests suggested an active leishmanial infection, and a Leishmania species was identified by direct cytology of a sample from the osteolytic area and by indirect immunohistochemistry of a bone biopsy. The dog's condition improved when it was treated with meglumine antimonate and allopurinol. Because of the large osteolytic area and the increased use of the affected leg, a partial tarsal arthrodesis was performed to prevent a fracture. Five months after the surgery, the osteolytic area had healed completely and the calcaneus periosteal reaction had disappeared.
authors.affiliation: Department of Surgery, Veterinary School, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Franch
authors.forename: J
authors.initials: J
authors.lastname: Pastor
authors.forename: E
authors.initials: E
authors.lastname: Torrent
authors.forename: P
authors.initials: P
authors.lastname: Lafuente
authors.forename: M C
authors.initials: MC
authors.lastname: Diaz-Bertrana
authors.forename: A
authors.initials: A
authors.lastname: Munilla
authors.forename: I
authors.initials: I
authors.lastname: Durall
mesh_terms: D000493:Allopurinol / Q000627:therapeutic use*; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D001174:Arthrodesis / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery; D004285:Dogs; D006614:Hindlimb / Q000469:parasitology / Q000473:pathology; D007891:Leishmania / Q000302:isolation & purification; D007896:Leishmaniasis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D008297:Male; D008536:Meglumine / Q000627:therapeutic use*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000627:therapeutic use*; D013640:Tarsal Joints / Q000469:parasitology / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D000493:Allopurinol; D008536:Meglumine; D000077485:Meglumine Antimoniate