Neurosurgical access to cortical areas in the lateral fissure of primates.
In this report, a method is presented for gaining direct access to cortical areas within the lateral fissure of primates for neuroanatomical tracer injections and electrode array implantation. Compared to areas on the surface of the brain, the anatomical and physiological properties of areas within the fissure are poorly understood. Typically, access to these areas is indirectly achieved by ablating or passing through intervening areas. To enable direct experimental access, a neurosurgical technique was developed in primates whereby the banks of the lateral fissure were retracted with sparing of the vascular network and intervening areas. In some animals, anatomical tracers were directly injected into target fields without contamination of other areas. In others, multichannel electrode arrays were implanted into target areas for chronic recording of neural activity. Since, these techniques could be adapted for exploration of areas within other sulci, the approach represents an important advance in efforts to elucidate the functional organization of the primate cerebral cortex.
Hackett
Troy A
TA
Department of Hearing and Speech Sciences, Vanderbilt University, 301 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA. troy.a.hackett@vanderbilt.edu
Karmos
George
G
Schroeder
Charles E
CE
Ulbert
Istvan
I
Sterbing-D'Angelo
Susanne J
SJ
D'Angelo
William R
WR
Kajikawa
Yoshinao
Y
Blumell
Suzanne
S
de la Mothe
Lisa
L
D000818:Animals; D016477:Artifacts; D002144:Callithrix; D002540:Cerebral Cortex / Q000098:blood supply / Q000601:surgery*; D004396:Coloring Agents; D004210:Dissection / Q000295:instrumentation / Q000379:methods; D004566:Electrodes / Q000592:standards; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods; D005701:Galago; D008253:Macaca mulatta; D008255:Macaca radiata; D020768:Middle Cerebral Artery / Q000033:anatomy & histology / Q000293:injuries / Q000601:surgery; D009482:Neurophysiology / Q000295:instrumentation / Q000379:methods; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control; D011323:Primates / Q000033:anatomy & histology* / Q000601:surgery*; D013194:Staining and Labeling
D004396:Coloring Agents