title: Effect of chamber capacitance on Doppler flow pattern across restrictive defects in obligatory atrial-level shunts.
abstract: The right atrium has a significantly higher capacitance than the left atrium, and this may affect the Doppler flow pattern across an atrial septal defect (ASD) in unilateral atrioventricular (AV) valve atresia. This Doppler flow pattern is often used to assess ASD adequacy in this setting. We studied the effect of atrial capacitance and ASD size on the trans-ASD Doppler flow pattern in an in vivo flow model of alternate left or right AV valve atresia (LAVVA and RAVVA). We assessed trans-ASD Doppler flow patterns using the max/min velocity ratio and mean interatrial pressure gradients (PGs). In both models, ASD flow rate correlated with mean trans-ASD PG, but for similar flow rates the slope was higher in the LAVVA model. In LAVVA, a persistent PG was consistently observed, with low max/min ratio (median, 1.46; range, 1.03-3.13), whereas in RAVVA, phasic flow was common (median, 8.0; range, 2.8-20). Because atrial capacitance affects mean PG and Doppler flow pattern across the ASD, we propose that the assessment of ASD adequacy in RAVVA should not rely on Doppler findings.
authors.affiliation: Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giardini
authors.forename: Boris
authors.initials: B
authors.lastname: Schmitt
authors.forename: Anthony
authors.initials: A
authors.lastname: Azakie
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Tacy
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D002302:Cardiac Output / Q000502:physiology*; D003326:Coronary Circulation / Q000502:physiology*; D015150:Echocardiography, Doppler; D006325:Heart Atria / Q000000981:diagnostic imaging*; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging*; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging*; D066298:In Vitro Techniques; D023421:Models, Animal; D012756:Sheep