title: Peptidergic and non-peptidergic innervation and vasomotor responses of human lenticulostriate and posterior cerebral arteries.
abstract: The aim of the present study was to compare in man the innervation pattern and the functional responses to neuronal messengers in medium sized lenticulostriate and branches of the posterior cerebral arteries (PCA). The majority of the nerve fibers found were sympathetic and displayed specific immunoreactivity for tyrosine hydroxylase (TH) and neuropeptide Y (NPY). Only few nerve fibers displayed vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity. In both arteries, the contractions induced by noradrenaline (NA), NPY and 5-hydroxytryptamine (5-HT) and the relaxant responses induced by acetylcholine (ACh), VIP and pituitary adenylate cyclase activating peptide-27 (PACAP) as well as CGRP and SP were compared in vitro. In conclusion, there was no major difference in innervation pattern or vasomotor sensitivity (pEC50 and pIC50 values) between the two vessels. However, the general pattern indicates stronger vasomotor responses (Emax and Imax) in the PCA branches as compared to the lenticulostriate arteries which may lend support for the clinical observation of a difference in stroke expression between the two vascular areas.
authors.affiliation: Department of Neurology, Copenhagen University, Glostrup Hospital, 2600 Copenhagen, Denmark. ijo@tdcadsl.dk
authors.forename: Inger
authors.initials: I
authors.lastname: Jansen-Olesen
authors.forename: Sergio
authors.initials: S
authors.lastname: Gulbenkian
authors.forename: Ulla
authors.initials: U
authors.lastname: Engel
authors.forename: Manuel
authors.initials: M
authors.lastname: Cunha e Sá
authors.forename: Lars
authors.initials: L
authors.lastname: Edvinsson
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D001479:Basal Ganglia / Q000098:blood supply*; D002536:Cerebral Arteries / Q000294:innervation*; D006801:Humans; D007150:Immunohistochemistry; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009414:Nerve Growth Factors / Q000494:pharmacology; D009478:Neuropeptide Y / Q000494:pharmacology; D009479:Neuropeptides / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000502:physiology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D020769:Posterior Cerebral Artery / Q000294:innervation*; D012701:Serotonin / Q000494:pharmacology; D020521:Stroke / Q000503:physiopathology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology; D014666:Vasomotor System / Q000502:physiology*
chemical_list: C495401:ADCYAP1 protein, human; D009414:Nerve Growth Factors; D009478:Neuropeptide Y; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D012701:Serotonin; D014660:Vasoactive Intestinal Peptide; D000109:Acetylcholine; D009638:Norepinephrine