title: Presence of autoantibodies to apolipoprotein A-1 in patients with acute coronary syndrome further links autoimmunity to cardiovascular disease.
abstract: Anti-apolipoprotein A-1 (Apo A-1) autoantibodies were described in autoimmune disorders such as systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) and might be involved in the genesis of arterial and venous thrombotic events. To investigate the presence of these autoantibodies in patients with acute coronary syndrome (ACS) without other features of autoimmunity, we set up an enzyme-linked immunosorbent assay (ELISA) for anti-Apo A-1 antibodies. We used it to investigate their prevalence in ACS as compared to SLE and APS and correlated them to plasma Apo A-1 and serum amyloid A protein (SAA) concentrations. The prevalence of anti-Apo A-1 autoantibodies in the healthy control group was 1% (1/92), but was significantly higher in other groups: 21% (11/53) in ACS group (P=0.001), 13% (12/92) in SLE and/or APS group (P=0.005). Multiple linear regression revealed a significant correlation between plasma Apo A-1 (r=-0.72, P=0.013), plasma SAA concentration (r=0.76, P=0.0066) and anti-Apo A-1 IgG titre in ACS patients. The presence of anti-Apo A-1 autoantibodies in patients with ACS highlights an additional link between autoimmunity, inflammation and atherosclerosis.
authors.affiliation: Division of Immunology and Allergy and Department of Internal Medicine, Geneva University Hospital, 24 Micheli-Du-Crest, 1211 Geneva 14, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vuilleumier
authors.forename: Guido
authors.initials: G
authors.lastname: Reber
authors.forename: Richard
authors.initials: R
authors.lastname: James
authors.forename: Danielle
authors.initials: D
authors.lastname: Burger
authors.forename: Philippe
authors.initials: P
authors.lastname: de Moerloose
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Dayer
authors.forename: Pascale
authors.initials: P
authors.lastname: Roux-Lombard
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016632:Apolipoprotein A-I / Q000097:blood / Q000276:immunology*; D015551:Autoimmunity; D003324:Coronary Artery Disease / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: D017152:Antibodies, Antiphospholipid; D016632:Apolipoprotein A-I; D007074:Immunoglobulin G