Thymopoiesis in 4 dimensions.
Developing T cells undergo long-range migrations in the thymus that are tightly linked to their developmental program. In this review, we discuss the anatomical positioning of developing T cells in the thymus, review what we know about how cells move in the thymus, and point out unresolved questions. We also discuss new imaging technologies and interdisciplinary approaches and discuss how the promise they offer to addressing these questions.
Witt
Colleen M
CM
Division of Immunology, Department of Molecular and Cell Biology, 479 Life Sciences Addition, University of California, Berkeley, CA 94720, USA. cwitt@uclink.berkeley.edu
Robey
Ellen A
EA
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000276:immunology* / Q000502:physiology; D019070:Cell Lineage / Q000276:immunology* / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D018925:Chemokines / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology* / Q000502:physiology
D018925:Chemokines