[Essentiale and riboxin induce immunomodulant activity of erythrocyte stroma in rats with toxic anemia and in intact animals].
The stroma of red blood cells in rats injected with riboxin after extracorporal treatment with essentiale acquired immunomodulant properties, with a significant increase in Mg2+ -ATPase activity. Light erythrocytes producing immunosuppressing action appeared in the blood of animals poisoned with phenylhydrazine or sodium nitrite. Introduction of hemotropic poisons reduced the activity of Mg2+ -ATPase in the stroma. Riboxin injections in poisoned animals, followed by essentiale treatment of the stroma induced immunostimulating properties and normalized Mg2+ -ATPase activity of erythrocyte membranes.
Lzareva
G A
GA
Brovkina
I L
IL
Prokopenko
L G
LG
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000494:pharmacology; D000740:Anemia / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004912:Erythrocytes / Q000276:immunology*; D007290:Inosine Diphosphate / Q000008:administration & dosage* / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep
D000276:Adjuvants, Immunologic; D010713:Phosphatidylcholines; C011246:essential 303 forte; D007290:Inosine Diphosphate