title: Electroosmotic guiding of sample flows in a laminar flow chamber.
abstract: The so-called address-flow principle is described: a valveless, electroosmotically driven technology used for controlling the stream profile in a laminar flow chamber. The method is explained, and a theoretical description and experimental verification are presented. Adjustment of the flow of two electroosmotically controlled guiding streams, running parallel to a central sample stream, can be used for positioning the sample stream in the dimension perpendicular to the flow direction. The results presented show that address-flow microfluidics allow easy and accurate control of sample stream position and width. The electroosmotic flow (EOF)-controlled guiding of microfluidic flows described in this paper, is a new unit operation that might aid in separation and collection in microfluidic devices. One possible application of address-flow microfluidics is guiding of capillary electrophoresis-separated components over a multisensor array, in order to perform affinity assays.
authors.affiliation: Biochip Group, MESA+ Research Institute, University of Twente, Enschede, The Netherlands.
authors.forename: Geert A J
authors.initials: GA
authors.lastname: Besselink
authors.forename: Paul
authors.initials: P
authors.lastname: Vulto
authors.forename: Rob G H
authors.initials: RG
authors.lastname: Lammertink
authors.forename: Stefan
authors.initials: S
authors.lastname: Schlautmann
authors.forename: Albert
authors.initials: A
authors.lastname: van den Berg
authors.forename: Wouter
authors.initials: W
authors.lastname: Olthuis
authors.forename: Gerard H M
authors.initials: GH
authors.lastname: Engbers
authors.forename: Richard B M
authors.initials: RB
authors.lastname: Schasfoort
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004867:Equipment Design; D046210:Microfluidic Analytical Techniques; D044085:Microfluidics / Q000295:instrumentation / Q000379:methods*; D008962:Models, Theoretical; D011506:Proteins / Q000032:analysis; D012212:Rheology; D012710:Serum Albumin, Bovine / Q000032:analysis
chemical_list: D011506:Proteins; D012710:Serum Albumin, Bovine