Laboratory animal models of temporal lobe epilepsy.
Temporal lobe epilepsy is a common human disease that is difficult to treat. The pathogenesis of temporal lobe epilepsy, which holds many unresolved questions, and opportunities for creating more effective treatments and preventative strategies are reviewed herein. Laboratory animal models are essential to meet these challenges. How models are created, how they compare with each other and with the disease in human patients, and how they advance our understanding of temporal lobe epilepsy are described.
Buckmaster
Paul S
PS
Department of Comparative Medicine, Stanford University, 300 Pasteur Drive, R321 Edwards Building, Stanford, California 94305-5342, USA.
D000818:Animals; D000830:Animals, Laboratory; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008992:Monkey Diseases / Q000209:etiology / Q000473:pathology; D011323:Primates; D051381:Rats; D013045:Species Specificity