Mitochondrial permeability transition triggers the release of mtDNA fragments.
Fragments of mitochondrial DNA are released from mitochondria upon opening of the mitochondrial permeability transition pore. Cyclosporin A, an inhibitor of pore opening, completely prevented the release of mitochondrial fragments. Induction of mitochondrial permeability transition and subsequent release of the fragments of mitochondrial DNA could be one cause of genomic instability in the cell.
Patrushev
M
M
Institute of Theoretical and Experimental Biophysics, Pushchino 142290, Russia.
Kasymov
V
V
Patrusheva
V
V
Ushakova
T
T
Gogvadze
V
V
Gaziev
A
A
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology; D004272:DNA, Mitochondrial / Q000378:metabolism*; D007473:Ion Channels / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008930:Mitochondria, Liver / Q000187:drug effects / Q000502:physiology*; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D010539:Permeability
D004272:DNA, Mitochondrial; D007473:Ion Channels; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D016572:Cyclosporine