[PPARgamma and bone metabolism].
PPARgamma is a ligand-dependent nuclear receptor and regulates adipogenesis and associates with diabetes, obesity. Recently, relationship between PPARgamma and bone metabolism was investigated. Here, we report the molecular mechanism of PPARgamma transcriptional activity and the suppression of PPARgamma activity by cytokines in bone marrow-derived mesenchymal stem cells.
Takada
Ichiro
I
The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan.
Kato
Shigeaki
S
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D051379:Mice; D047495:PPAR gamma / Q000235:genetics / Q000502:physiology*; D015533:Transcriptional Activation / Q000502:physiology
D016207:Cytokines; D047495:PPAR gamma