title: Challenging conventional wisdom: the etiologic role of dopamine oxidative stress in Parkinson's disease.
abstract: Oxidative stress is well documented in Parkinson's disease (PD) and has been attributed to dopamine oxidative metabolism. However, evidence of oxidative stress is found in a variety of neurodegenerative disorders, suggesting that more general factors are responsible or that cytodestructive processes secondarily generate oxyradical products. Increasing evidence points away from dopamine metabolism as an important contributor to PD neurodegeneration. Predictions from the dopamine oxidative stress hypothesis of PD reveal multiple inconsistencies. Although the clinical and therapeutic importance of the nigrostriatal dopaminergic system is undeniable, PD neuropathology is much more widespread.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. eahlskog@mayo.edu
authors.forename: J Eric
authors.initials: JE
authors.lastname: Ahlskog
mesh_terms: D001933:Brain Stem / Q000378:metabolism; D003704:Dementia / Q000150:complications; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D016631:Lewy Bodies / Q000378:metabolism; D009410:Nerve Degeneration / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D000857:Olfaction Disorders / Q000150:complications; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000150:complications / Q000209:etiology / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D020187:REM Sleep Behavior Disorder / Q000150:complications; D051843:Synucleins; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D051843:Synucleins; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex; D004298:Dopamine