title: Finding their groove; bifunctional molecules arrest growth of cancer cells.
abstract: In this issue, Dickinson et al. describe an exciting advance in the search for inhibitors of transcription that function well in cells . The authors screen for small molecules that selectively damage DNA and identify a histone gene as a potential new target for cancer therapeutic development.
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, MI 48104, USA.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Mapp
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D015972:Gene Expression Regulation, Neoplastic; D006657:Histones / Q000235:genetics*; D006801:Humans; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D006657:Histones; D009363:Neoplasm Proteins; D004247:DNA