title: Quantitative analysis of intraprocedural myocardial contrast echocardiography during percutaneous septal ablation for hypertrophic obstructive cardiomyopathy.
abstract: OBJECTIVE
  We tested whether procedural success of percutaneous septal ablation for hypertrophic obstructive cardiomyopathy is related to quantitative measurements of intraprocedural myocardial contrast echocardiography.
  
  
  RESULTS
  In a study group of 34 patients, the mean area of the contrast depot was 8.5+/-2.5 cm2, its length along the left ventricular endocardial border 3.0+/-0.7 cm and its proximal edge 2.0+/-0.6 cm upstream the point of mitral-septal contact. Clinical and hemodynamic success was achieved in all but one patient 3 months following percutaneous septal ablation. The proximal edge of the ablation lesion correlated weakly (r=0.5) with the proximal edge of the contrast depot with respect to their distance from the mitral valve leaflet tips. No other correlations were found between the efficacy of percutaneous septal ablation and various quantitative measurements of intraprocedural contrast echocardiography.
  
  
  CONCLUSIONS
  The localization of the ablation lesion 3 months after percutaneous septal ablation is predicted by the localization of the contrast depot with respect to the point of mitral-septal contact. The final hemodynamic effect of the ablation lesion, however, does not correlate with quantitative parameters of intraprocedural contrast echocardiography, but appears to be the result of an individual remodeling process.
authors.affiliation: Department of Cardiology, Heart Center North Rhine-Westphalia, Ruhr University, Georgstrasse 11, 32545 Bad Oeynhausen, Germany. akohlstaedt@hdz-nrw.de
authors.forename: Detlef
authors.initials: D
authors.lastname: Hering
authors.forename: Dirk
authors.initials: D
authors.lastname: Welge
authors.forename: Dieter
authors.initials: D
authors.lastname: Fassbender
authors.forename: Dieter
authors.initials: D
authors.lastname: Horstkotte
authors.forename: Lothar
authors.initials: L
authors.lastname: Faber
mesh_terms: D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000601:surgery; D017115:Catheter Ablation / Q000379:methods*; D016009:Chi-Square Distribution; D004452:Echocardiography / Q000379:methods; D006801:Humans; D018709:Statistics, Nonparametric; D018084:Ultrasonography, Interventional / Q000379:methods*