title: [Polymorphism of angiotensin converting enzyme gene and natural longevity in the Xinjiang Uygur people: an association study].
abstract: OBJECTIVE
  To explore the distribution of I/D polymorphisms of angiotensin converting enzyme (ACE) gene and its relation to natural longevity in the Xinjiang Uygur people.
  
  
  METHODS
  Polymerize chain reaction, single strand conformation polymorphism, and direct sequencing technique were used to test the I/D polymorphisms of ACE gene in 42 centenarians, 102 people aged 90-99, 70 people aged 65-70, 53 cases of natural death aged 65-70 were used as controls.
  
  
  RESULTS
  The frequencies of ACE genotypes DD, DI, and II were 28.6%, 30.9%, and 40.5% respectively in the centenarian group, the frequency rates of D and I alleles were 0.44 and 0.56. The frequency rate of D/D genotype of the centenarian group was significantly higher than that of the group aged 65-70 (28.6% vs. 12.9%, chi2 = 4.25, P < 0.05), however, not significantly different from that of the group aged 90 (P > 0.05). The frequency rate of D allele of the group of centenarian was significantly higher than that of the group aged 65-70 (44.0% vs. 36.4%, chi2 = 4.47, P < 0.05). The frequency rates of genotype D/D and D alleles were significantly higher in the centenarian group than in the controls (both P < 0.01).
  
  
  CONCLUSIONS
  ACE gene polymorphism is closely correlated with life span of individuals. Longevity is the result of pleiotropic age-dependent influence of multiple factors.
authors.affiliation: Cardiology Department of Internal Medicine, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Mayila
authors.initials: M
authors.lastname: Wufuer
authors.forename: Ming-wu
authors.initials: MW
authors.lastname: Fang
authors.forename: Zu-heng
authors.initials: ZH
authors.lastname: Cheng
authors.forename: Chang-chun
authors.initials: CC
authors.lastname: Qiu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000208:ethnology; D002886:Chromosomes, Human, Pair 17; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational
chemical_list: D007703:Peptidyl-Dipeptidase A