title: Neurocomputational models of the remote effects of focal brain damage.
abstract: Sudden localized brain damage, such as occurs in stroke, produces neurological deficits directly attributable to the damaged site. In addition, other clinical deficits occur due to secondary "remote" effects that functionally impair the remaining intact brain regions (e.g., due to their sudden disconnection from the damaged area), a phenomenon known as diaschisis. The underlying mechanisms of these remote effects, particularly those involving interactions between the left and right cerebral hemispheres, have proven somewhat difficult to understand in the context of current theories of hemispheric specialization. This article describes some recent neurocomputational models done in the author's research group that try to explain diaschisis qualitatively. These studies show that both specialization and diaschisis can be accounted for with a single model of hemispheric interactions. Further, the results suggest that left-right subcortical influences may be much more important in influencing hemispheric specialization than is generally recognized.
authors.affiliation: Departments of Computer Science and Neurology, UMIACS, A.V. Williams Building, University of Maryland, College Park, MD 20742, USA. reggia@cs.umd.edu
authors.forename: James A
authors.initials: JA
authors.lastname: Reggia
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology; D001925:Brain Damage, Chronic / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D003198:Computer Simulation; D003337:Corpus Callosum / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D009474:Neurons