title: Rapid analysis of total plasma homocysteine by tandem mass spectrometry.
abstract: Elevated plasma homocysteine levels may be an independent risk factor for premature vascular disease. Early detection and population screening are warranted to recognise hyperhomocysteinemia and initiate homocysteine lowering therapy. Current methods for homocysteine analysis are time consuming, labor intensive and/or expensive. We developed a sensitive and fast method for homocysteine analysis based on tandem mass spectrometry that avoids the need for derivatization and preanalytical chromatography.
authors.affiliation: Unit of Biochemical Genetics, University Children's Hospital of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
authors.forename: Karin
authors.initials: K
authors.lastname: Tuschl
authors.forename: Olaf A
authors.initials: OA
authors.lastname: Bodamer
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Erwa
authors.forename: Adolf
authors.initials: A
authors.lastname: Mühl
mesh_terms: D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D013058:Mass Spectrometry; D012015:Reference Standards; D013048:Specimen Handling
chemical_list: D006710:Homocysteine