[Significance of Toll-like receptors in the pathophysiology of surgical sepsis].
The discovery of Toll-like receptors has substantially changed our knowledge of pathogen recognition. 11 Toll-like receptors have so far been described in humans. These recognize distinct pathogen associated molecular patterns, as well as endogenous ligands and small molecular synthetic compounds. TLRs have a multifunctional role in pathogen-triggered immune responses and represent an important connection between the "innate" and "adaptive" immunity. The role of the TLRs in the recognition of pathogens renders them a key figure in the activation of the immune response during surgical sepsis. However, emerging evidence points to a fundamental role in tumorigenesis, transplantation, wound healing, atherogenesis and inflammatory bowel disease. The aim hence was to review experimental data pertaining to the activation of TLR signalling pathways in conditions associated with surgical sepsis. A systematic review of the literature was undertaken by searching the MEDLINE database for the period 1966-2004 without language restriction. The paper also analyses the possible therapeutic utilization of the TLR signalling pathways in surgical sepsis.
Romics
László
L
Department of Surgery, Cork University Hospital, National University of Ireland, Cork, Ireland. Laszlo.Romics@umassmed.edu
Coffey
John Calvin
JC
Wang
Jiang Huai
JH
Redmond
Henry Paul
HP
Szabó
Gyöngyi
G
D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018805:Sepsis / Q000209:etiology / Q000378:metabolism*; D015398:Signal Transduction; D013530:Surgical Wound Infection / Q000378:metabolism*; D051193:Toll-Like Receptors
D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors