Chromatin modifiers and carcinogenesis.
Access of gene regulatory factors to the eukaryotic genome is modulated by chromatin. The organization of this nucleoprotein complex is highly dynamic and tightly regulated. The control of wide-ranging nuclear processes through the configuration of chromatin is achieved by the concerted actions of ATP-dependent chromatin-remodeling complexes and histone-modifying enzymes, and by the incorporation of specialized histone variants. It is becoming clear that perturbation of these chromatin modifiers can lead to cancer. Recent findings illustrate the mechanisms by which chromatin influences cancer development, and aid understanding of the regulation of chromatin organization, cellular transformation and the connections between tumor suppressor and oncogene function.
Gregory
Richard I
RI
Gene Expression and Regulation Program, and Molecular and Cellular Oncogenesis Program, Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
Shiekhattar
Ramin
R
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009362:Neoplasm Metastasis; D009687:Nuclear Proteins / Q000378:metabolism*
D002843:Chromatin; D006657:Histones; D009687:Nuclear Proteins