title: The promise of minocycline in neurology.
abstract: The capacity of minocycline to alleviate disease for several neurological disorders in animals is increasingly being recognised. Indeed, that one drug alone can attenuate the severity of disease in stroke, multiple sclerosis, spinal-cord injury, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis is astounding. In this review, we describe the evidence for the efficacy of minocycline in several animal models of neurological disease, discuss the mechanisms by which minocycline affects a range of neurological diseases with diverse causes, and introduce the emerging investigation of minocycline in clinical neurology. The encouraging results of minocycline in experimental neurology bode well for its therapeutic use in human neurological diseases.
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada. vyong@ucalgary.ca
authors.forename: V Wee
authors.initials: VW
authors.lastname: Yong
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wells
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Giuliani
authors.forename: Steven
authors.initials: S
authors.lastname: Casha
authors.forename: Christopher
authors.initials: C
authors.lastname: Power
authors.forename: Luanne M
authors.initials: LM
authors.lastname: Metz
mesh_terms: D000818:Animals; D006801:Humans; D008911:Minocycline / Q000627:therapeutic use*; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D008911:Minocycline