title: [Effects of Xiaochaihu Tang, a traditional Chinese medicinal preparation, on ectopic endometrium in rats].
abstract: OBJECTIVE
  To investigate the effects of Xiaochaihu Tang (XCHT), a traditional Chinese medicinal preparation, on ectopic endometrium in rats.
  
  
  METHODS
  In rat models of endometriosis, the effect of XCHT of ultrastructure of the ectopic endometrium was observed by transmission electron microscopy.
  
  
  RESULTS
  After treatment with XCHT at moderate (500 g/L) or high dose (750 g/L), ectopic endometrial growth was significantly inhibited (P<0.01); small-dose XCHT (250 g/L) was less effective (P<0.05). The volume of endometrium implant in the control group remained unchanged (P>0.05). The glandular cells in the endometrial implant after therapy with moderate- or high-dose XCHT showed characteristic features of apoptosis, presented by decreased cell size, karyopyknosis, cytoplasm and nuclear chromatin condensation, increased density and presence of apoptotic bodies. Some stromal cells displayed degenerative and necrotic changes.
  
  
  CONCLUSIONS
  XCHT may inhibit the growth of ectopic endometrium by inducing cell death in the form of apoptosis and necrosis.
authors.affiliation: Department of Physiology, Medical College of Jinan University, Guangzhou 510632, China. lihzh@jnu.edu.cn
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.forename: Lian-dong
authors.initials: LD
authors.lastname: Zuo
authors.forename: Hong-yi
authors.initials: HY
authors.lastname: Li
authors.forename: Wen-ju
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Zi-nen
authors.initials: ZN
authors.lastname: Wang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology; D004717:Endometrium / Q000648:ultrastructure*; D005260:Female; D009336:Necrosis; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; C461320:shosaiko-to