The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii.
The lactoferrin-derived peptide hLF(1-11), but not its control peptide, was highly effective against five multidrug-resistant Acinetobacter baumannii strains in vitro (3 to 4 log reduction) and against four of these strains in an experimental infection in mice (2 to 3 log reduction). Therefore, this peptide is a promising candidate as a novel agent against infections with multidrug-resistant A. baumannii.
Dijkshoorn
Lenie
L
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. l.dijkshoorn@lumc.nl
Brouwer
Carlo P J M
CP
Bogaards
Sylvia J P
SJ
Nemec
Alexandr
A
van den Broek
Peterhans J
PJ
Nibbering
Peter H
PH
D000151:Acinetobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects*; D000595:Amino Acid Sequence; D000818:Animals; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D024901:Drug Resistance, Multiple, Bacterial; D007781:Lactoferrin; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000627:therapeutic use*
D010446:Peptide Fragments; C466658:lactoferrin (1-11), human; D007781:Lactoferrin