Synthesis of a tripeptide derivative containing the gln-arg hydroxyethylene dipeptide isostere.
[structure: see text] The protected hydroxyethylene dipeptide isostere of Gln-Arg and the tripeptide derivative 1 were synthesized as components of potential peptidase inhibitors.
Brewer
Matthias
M
Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
James
Clint A
CA
Rich
Daniel H
DH
D001120:Arginine / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry; D005030:Ethylenes / Q000737:chemistry*; D005973:Glutamine / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D004151:Dipeptides; D005030:Ethylenes; D007783:Lactones; D009842:Oligopeptides; D005973:Glutamine; C067254:hydroxyethylene; D001120:Arginine