title: Cup inclination and serum concentration of cobalt and chromium after metal-on-metal total hip arthroplasty.
abstract: We investigated whether cup inclination influences serum levels of cobalt and chromium after metal-on-metal total hip arthroplasty. Out of a consecutive series, 3 groups of 20 patients each were established according to their cup inclination: greatest inclination (55 degrees -63 degrees, mean 58 degrees), intermediate inclination (44 degrees -46 degrees, mean 45 degrees), and smallest inclination (23 degrees -37 degrees, mean 33 degrees). We did not detect any statistically significant difference of serum cobalt (P = .23) or serum chromium (P = .13) levels between the 3 groups applying the Kruskal Wallis test. However, 3 patients with cup inclinations of 58 degrees , 63 degrees , and 61 degrees exhibited 9.8-53.6-fold elevated cobalt and 9.5-30.5-fold elevated chromium levels when compared with the median concentrations of this trial. We therefore recommend accurate cup placement also for metal-on-metal articulations.
authors.affiliation: Department of Orthopaedics, Vienna General Hospital, Vienna, Austria.
authors.forename: Wolfram
authors.initials: W
authors.lastname: Brodner
authors.forename: Alexander
authors.initials: A
authors.lastname: Grübl
authors.forename: Rafael
authors.initials: R
authors.lastname: Jankovsky
authors.forename: Vanee
authors.initials: V
authors.lastname: Meisinger
authors.forename: Stephan
authors.initials: S
authors.lastname: Lehr
authors.forename: Florian
authors.initials: F
authors.lastname: Gottsauner-Wolf
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D002857:Chromium / Q000097:blood*; D003035:Cobalt / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D011474:Prosthesis Design
chemical_list: D002857:Chromium; D003035:Cobalt