title: Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase.
abstract: An HTS campaign aimed at the identification of inhibitors of HIV integrase showed that the methanol extract from the buds of a Eucalyptus globoidea was active. Bioassay guided fractionation of this extract resulted in the purification and structural elucidation of the lignan, globoidnan A (1) as the only compound in the extract responsible for the inhibition of HIV integrase. The compound was found to inhibit the combined 3' processing and strand transfer activity of HIV integrase with an IC50=0.64 microM.
authors.affiliation: Cerylid Biosciences Ltd., 576 Swan Street, Richmond, Vic. 3121, Australia.
authors.forename: Simon P B
authors.initials: SP
authors.lastname: Ovenden
authors.forename: Jin
authors.initials: J
authors.lastname: Yu
authors.forename: Soo San
authors.initials: SS
authors.lastname: Wan
authors.forename: Gian
authors.initials: G
authors.lastname: Sberna
authors.forename: R Murray
authors.initials: RM
authors.lastname: Tait
authors.forename: David
authors.initials: D
authors.lastname: Rhodes
authors.forename: Susan
authors.initials: S
authors.lastname: Cox
authors.forename: Jonathan
authors.initials: J
authors.lastname: Coates
authors.forename: Neville G
authors.initials: NG
authors.lastname: Walsh
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Meurer-Grimes
mesh_terms: D005052:Eucalyptus / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D019428:HIV Integrase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000201:enzymology; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure
chemical_list: D019428:HIV Integrase Inhibitors; D017705:Lignans; C496759:globoidnan A