Paraventricular nucleus neurons producing neurotensin after lipopolysaccharide treatment project to the median eminence.
Inflammation consists in secretion of cytokines that stimulate the hypothalamo-pituitary-adrenal (HPA) axis to release the anti-inflammatory corticosterone. Upstream in this axis are corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) whose multipeptidergic phenotype changes: both corticotropin-releasing hormone mRNAs and neurotensin mRNAs are up-regulated. Combining in situ hybridization with a retrograde neuronal marker, we demonstrated that neurotensin-containing neurons in the paraventricular nucleus project to the median eminence.
Loum-Ribot
Elodie
E
Laboratoire des Régulations Neuroendocriniennes, EA2972, Université Bordeaux 1, avenue des Facultés, 33405 Talence, France. loumelodie@yahoo.fr
Lafon
Pierrette
P
Chaigniau
Michel
M
Pape
Jean-Rémi
JR
Tramu
Gérard
G
Corio
Marc
M
D000210:Acute-Phase Reaction / Q000139:chemically induced / Q000378:metabolism; D000578:Amidines / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D005456:Fluorescent Dyes / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism; D008070:Lipopolysaccharides; D008297:Male; D008473:Median Eminence / Q000166:cytology / Q000502:physiology*; D009434:Neural Pathways / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D015213:Neuroimmunomodulation / Q000502:physiology; D009474:Neurons / Q000276:immunology / Q000378:metabolism*; D009496:Neurotensin / Q000276:immunology / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation
D000578:Amidines; D005456:Fluorescent Dyes; D008070:Lipopolysaccharides; C031455:diamidino compound 253-50; D009496:Neurotensin