[Significance of p53 gene mutation and P53 protein expression abnormality on the prognosis of esophageal cancer: a meta-analysis study].
OBJECTIVE
To evaluate the prognostic significance of p53 mutation and P53 protein expression abnormality among esophageal cancer.


METHODS
The results of 27 random controlled trials from 1990 to 2003 were analyzed by meta-analysis method. The overall positive rate of p53 was 52.9% among the cumulative 2174 cases. Relative hazard (RH) was applied to evaluate the risk of disease and all data were analyzed by Dersimonian-Laird method.


RESULTS
The analysis for homogeneity (q statistics test) showed that all eligible studies were with heterogeneity (q = 59.88, P < 0.005). The combined RH was 2.07 and 95% confidence interval was 1.58-2.70.


CONCLUSIONS
Findings showed that p53 was a poor prognosis biomarker for esophageal cancer gene diagnosis but might benefit to the strategy of treatment.
Wang
Xiao-li
XL
Institute of Environment Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhang
Chun-mei
CM
Shi
Lü-yuan
LY
Yu
Hong-ping
HP
Xu
Shun-Qing
SQ
D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000378:metabolism; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis* / Q000235:genetics
D016159:Tumor Suppressor Protein p53