title: Homeostatic model assessment and risk for hypertension during pregnancy: a longitudinal prospective study.
abstract: The purpose of this study was to determine the association between insulin resistance and hypertension during pregnancy with the homeostatic model assessment (HOMA-IR). A longitudinal prospective study was carried out. One hundred sixty normotensive pregnant women were followed from the first trimester until delivery. HOMA-IR levels were determined each trimester. Statistical analysis included one-way analysis of variance and multivariate logistic regression. At follow-up, 134 women (83.8%) remained normotensive, 18 (11.2%) developed gestational hypertension, and 8 (5%) developed preeclampsia. At first trimester, HOMA-IR levels were higher in women who developed gestational hypertension (2.1 +/- 0.2) than in women who developed preeclampsia (1.2 +/- 0.0), or remained normotensive (1.2 +/- 0.3); p < 0.01. In the logistic regression analysis, HOMA-IR levels at first trimester were statistically significant ( p = 0.03) to predict development of gestational hypertension. Our results support the use of the HOMA-IR as an alternative index for the assessment of the risk for hypertension during pregnancy.
authors.affiliation: Unit of Clinical Epidemiological Research, Department of Obstetrics and Gynecology, Mexican Institute of Social Security, Leon, Mexico.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Romero-Gutiérrez
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Malacara
authors.forename: Norma
authors.initials: N
authors.lastname: Amador
authors.forename: César
authors.initials: C
authors.lastname: Fierro-Martínez
authors.forename: Luis Manuel
authors.initials: LM
authors.lastname: Muñoz-Guevara
authors.forename: Roberto
authors.initials: R
authors.lastname: Molina-Rodríguez
mesh_terms: D000328:Adult; D003661:Decision Support Techniques; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D008137:Longitudinal Studies; D008800:Mexico; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011264:Pregnancy Trimesters; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index