[Correlation between some stress-realizing and stress-limiting systems in an acute period of ischemic stroke].
Concentrations of stimulating (glutamate, aspartate) and inhibitory (GAMK, glycin) amino acids were measured in cerebrospinal liquid of 67 patients with ischemic stroke. The condition of stress-realising and stress-limiting systems (SRS and SLS) was assessed by dynamics of stimulating and inhibitory amino acids. High and rapidly increasing concentration of glutamate within the first 24 h of the disease predicts a poor prognosis. Early rise of GAMK concentration is a favourable and reliable prognostic sign. Hyperactivation of glutamatergic system and deficiency of inhibitory GAMK-ergic system cause imbalance between mediators and metabolites of SRS and SLS. The severity and duration of this imbalance determine severity of clinical symptoms and outcome of the disease.
Matsko
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MA
Ivanova
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D000208:Acute Disease; D000328:Adult; D001224:Aspartic Acid / Q000134:cerebrospinal fluid*; D002545:Brain Ischemia / Q000134:cerebrospinal fluid* / Q000523:psychology; D005260:Female; D018698:Glutamic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000134:cerebrospinal fluid* / Q000523:psychology; D020521:Stroke / Q000134:cerebrospinal fluid* / Q000523:psychology; D013997:Time Factors
D001224:Aspartic Acid; D018698:Glutamic Acid