10-membered macrolides from the insect pathogenic fungus Cordyceps militaris BCC 2816.
Three new 10-membered macrolides (1-3) have been isolated from the entomopathogenic fungus Cordyceps militaris BCC 2816, together with six known compounds, cepharosporolides C (4), E (5), and F (6), 2-carboxymethyl-4-(3'-hydroxybutyl)furan (7), cordycepin (8), and pyridine-2,6-dicarboxylic acid. The structures were determined by analysis of NMR data, and an X-ray analysis was performed to confirm the structure of 1. The antimalarial activity of 1-4 and 8 against Plasmodium falciparum K1 was evaluated.
Rukachaisirikul
Vatcharin
V
Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand. vatcharin.r@psu.ac.th
Pramjit
Songyos
S
Pakawatchai
Chaveng
C
Isaka
Masahiko
M
Supothina
Sumalee
S
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032661:Cordyceps / Q000737:chemistry*; D018360:Crystallography, X-Ray; D018432:Drug Resistance, Multiple; D020128:Inhibitory Concentration 50; D007313:Insecta; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects*; D013785:Thailand
D000962:Antimalarials; D018942:Macrolides