title: Emerging technologies for the identification of therapeutic targets for the management of pre-eclampsia.
abstract: Pre-eclampsia is a common and serious complication of pregnancy characterised by hypertension and proteinuria. Genetic and environmental factors influence the occurrence and progression of the disease. Emerging experimental systems and increasingly specific analytical methods for the study of differences between normal and pre-eclamptic placentae are close to identifying specific indicators of disease, which may allow early diagnosis and intervention and reveal targets against which therapeutic agents can be developed.
authors.forename: D C
authors.initials: DC
authors.lastname: Pritlove
authors.forename: B K
authors.initials: BK
authors.lastname: Tan
authors.forename: N C J
authors.initials: NC
authors.lastname: de Wit
authors.forename: M
authors.initials: M
authors.lastname: Vatish
mesh_terms: D000328:Adult; D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000235:genetics; D019090:Case Management; D002458:Cell Fractionation / Q000295:instrumentation / Q000379:methods; D019295:Computational Biology; D050761:Cyclin-Dependent Kinase Inhibitor p57; D005260:Female; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics; D007335:Insulin-Like Growth Factor II / Q000172:deficiency / Q000235:genetics; D007511:Ischemia / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D009687:Nuclear Proteins / Q000172:deficiency / Q000235:genetics; D010920:Placenta / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D011247:Pregnancy; D040901:Proteomics; D012084:Renin-Angiotensin System / Q000502:physiology; D012307:Risk Factors; D014661:Vasoconstriction
chemical_list: D001798:Blood Proteins; C493964:CDKN1C protein, human; C493965:Cdkn1c protein, mouse; D050761:Cyclin-Dependent Kinase Inhibitor p57; D009687:Nuclear Proteins; D007335:Insulin-Like Growth Factor II