[The expression and interaction of cyclin D1 and p16 in fibroblasts of pathologic scars].
OBJECTIVE
To investigate the expression of cyclin D1, p16, AR and ER in fibroblasts of scars for further understanding the interaction of these factors and the roles that they play in scar development.


METHODS
Thirty samples of mature scar, hypertrophic scar and keloid were detected with immunohistochemical method (SP technique) and compared with normal skin.


RESULTS
There were on positive results in normal skin and mature scars. The expression of cyclin D1, p16 and AR was higher in hypertrophic scars and keloids than in normal skin with significant difference (P < 0.05). The expression of cyclin D1 in keloids was higher than in hypertrophic scars (P < 0.05). Though the expression of p16 was higher in keloids than in hypertrophic scars, the difference was not significant. There was significant correlation between the expression of cyclin D1 and AR in the pathologic scar.


CONCLUSIONS
The AR played an important role in scar formation and displayed its function through cyclin D1. The expression of p16 could suppress the excessive proliferation of cells to some extent. If the effect was not enough to resist the function of cyclin D1, long-term proliferation of cells would occur and lead to keloid formation. As the expression of cyclin D1 and p16 in hypertrophic scars was in a state of relative equilibrium, the cell proliferation showed a tendency of self-restriction.
Liu
Jia-Feng
JF
Department of Plastic Surgery, Union Hospital of Tongji Medical College Huazhong Science and Technical University, Wuhan 430022, China.
Zhang
Yi-Ming
YM
Yi
Chuan-Xun
CX
Sun
Jia-Ming
JM
Li
Wei-Wei
WW
D002921:Cicatrix / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000032:analysis / Q000378:metabolism*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000032:analysis / Q000378:metabolism*; D005347:Fibroblasts / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D011944:Receptors, Androgen / Q000032:analysis / Q000378:metabolism; D011960:Receptors, Estrogen / Q000032:analysis / Q000378:metabolism; D012867:Skin / Q000737:chemistry / Q000378:metabolism / Q000473:pathology
D019941:Cyclin-Dependent Kinase Inhibitor p16; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D019938:Cyclin D1