title: 5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa.
abstract: Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa activity and equal or slightly better selectivity relative to factor Xa.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA. jennifer.qiao@bms.com
authors.forename: Jennifer X
authors.initials: JX
authors.lastname: Qiao
authors.forename: Xuhong
authors.initials: X
authors.lastname: Cheng
authors.forename: Dilip P
authors.initials: DP
authors.lastname: Modi
authors.forename: Karen A
authors.initials: KA
authors.lastname: Rossi
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Luettgen
authors.forename: Robert M
authors.initials: RM
authors.lastname: Knabb
authors.forename: Prabhakar K
authors.initials: PK
authors.lastname: Jadhav
authors.forename: Ruth R
authors.initials: RR
authors.lastname: Wexler
mesh_terms: D015949:Factor IXa / Q000037:antagonists & inhibitors*; D065427:Factor Xa Inhibitors; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D065427:Factor Xa Inhibitors; D015842:Serine Proteinase Inhibitors; D013876:Thiophenes; D015949:Factor IXa