title: [Argyrophilic proteins of nucleolar organizers regions as markers of malignancy grade of anaplastic large-cell lymphoma and Hodgkin's lymphoma].
abstract: Expression of argyrophilic proteins of nucleolar organizers regions (Ag-NOR-proteins) was studied in tumor cells from 17 patients with a classic variant of anaplastic large-cell lymphoma (ALCL) and 22 patients with Hodgkin's lymphoma (HL). Eight cases of p80+ and nine cases of p80-ALCL were studied. HL was represented by 13 cases with lymphoid depletion by a reticular type and 9 cases with nodular sclerosis with a syncytial growth. Ag-NOR-proteins were identified using histochemical method with silver nitrate. The expression of Ag-NOR-proteins in tumor cells of ALCL and HL appeared intensive, being highest in ALCL cells, in p80+ cells of ALCL there was superexpression. The differences in expression of Ag-NOR-proteins point to different proliferative activity and growth of the above variants of ALCL and HL. The test for Ag-NOR-proteins expression can be recommended as an additional tool in differential diagnosis, determination of malignancy grade, assesssment of prognosis and sensitivity to chemotherapy.
authors.forename: N T
authors.initials: NT
authors.lastname: Raĭkhlin
authors.forename: I A
authors.initials: IA
authors.lastname: Bukaeva
authors.forename: N A
authors.initials: NA
authors.lastname: Probatova
authors.forename: E A
authors.initials: EA
authors.lastname: Smirnova
authors.forename: A I
authors.initials: AI
authors.lastname: Pavlovskaia
authors.forename: N N
authors.initials: NN
authors.lastname: Tupitsin
authors.forename: E N
authors.initials: EN
authors.lastname: Sholokhova
authors.forename: Sh Sh
authors.initials: ShSh
authors.lastname: Osmanov
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D034961:Antigens, Nuclear / Q000096:biosynthesis; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002455:Cell Division; D003937:Diagnosis, Differential; D006689:Hodgkin Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000096:biosynthesis; D009697:Nucleolus Organizer Region / Q000378:metabolism* / Q000473:pathology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; C051963:nucleolar organizer region associated proteins; C107023:p80(NPM-ALK) protein; D011505:Protein-Tyrosine Kinases