title: Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant Erythrina crista-galli.
abstract: Phomol (1), a novel antibiotic, was isolated from fermentations of a Phomopsis species in the course of a screening of endophytic fungi from the medicinal plant Erythrina crista-galli. For this Argentinean leguminosa antiinflammatory and neuroleptic activities have been described. The compound exhibits antifungal, antibacterial and weak cytotoxic acticity. The antiinflammatory activity was tested in different reporter gene assays (TNF-alpha, STAT1/STAT2 and NF-kappaB) and in an ear edema model in mice. In the reporter gene assays 1 exhibited no activity, whereas 1 showed interesting antiinflammatory activity in the mouse ear assay. The compound is a polyketide lactone and its structure was elucidated by spectroscopic methods.
authors.affiliation: Institute of Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Weber
authors.forename: Olov
authors.initials: O
authors.lastname: Sterner
authors.forename: Timm
authors.initials: T
authors.lastname: Anke
authors.forename: Susanna
authors.initials: S
authors.lastname: Gorzalczancy
authors.forename: Virginia
authors.initials: V
authors.lastname: Martino
authors.forename: Christina
authors.initials: C
authors.lastname: Acevedo
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001203:Ascomycota / Q000145:classification / Q000302:isolation & purification* / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004895:Erythrina / Q000382:microbiology*; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000382:microbiology*; D013755:Tetradecanoylphorbol Acetate / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D007783:Lactones; C494513:phomol; D013755:Tetradecanoylphorbol Acetate