Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone.
Biotransformation of nobiletin (1) by Aspergillus niger has been investigated, and the product obtained was determined as 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone (2). Antimutagenic activity of compound 2 was found, which showed suppressive effects on umu gene expression of the SOS response to DNA damage in Salmonella typhimurium TA1535/pSK1002, induced by the chemical mutagens furylfuramide, MeIQ, and Trp-P-1.
Okuno
Yoshiharu
Y
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan.
Miyazawa
Mitsuo
M
D001234:Aspergillus niger / Q000378:metabolism*; D001711:Biotransformation; D002957:Citrus / Q000737:chemistry; D047309:Flavones / Q000378:metabolism*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005668:Furylfuramide / Q000494:pharmacology*; D015394:Molecular Structure; D009152:Mutagenicity Tests; D010946:Plants, Medicinal / Q000737:chemistry / Q000378:metabolism*; D013014:SOS Response, Genetics; D012486:Salmonella typhimurium / Q000235:genetics* / Q000528:radiation effects
C495163:4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone; D047309:Flavones; D005419:Flavonoids; D005668:Furylfuramide; C008661:nobiletin