HIV-1 Env-specific cytotoxic T-lymphocyte responses in exposed, uninfected Kenyan sex workers: a prospective analysis.
The prospective significance of HIV-specific cytotoxic T lymphocyte (CTL) responses in highly exposed, persistently seronegative populations is unknown. In 1996-1997 we screened for CTL responses against HIV clade B Env in 39 recently enrolled Kenyan female sex workers, and followed these women prospectively. Annual HIV incidence was 5.8%. CTL were independently associated with age and recent HIV-1 exposure,but were not prospectively associated with protection in a multivariable model that included HIV-1 exposure and duration of sex work.
Kaul
Rupert
R
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya.
Rutherford
John
J
Rowland-Jones
Sarah L
SL
Kimani
Joshua
J
Onyango
James Isaiah
JI
Fowke
Keith
K
MacDonald
Kelly
K
Bwayo
Job J
JJ
McMichael
Andrew J
AJ
Plummer
Francis A
FA
D000328:Adult; D015331:Cohort Studies; D005260:Female; D015752:Genes, env / Q000276:immunology*; D018023:HIV Seronegativity / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007630:Kenya; D011446:Prospective Studies; D011477:Sex Work / Q000706:statistics & numerical data*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*