title: Improving the course of illness and promoting continuation of treatment of bipolar disorder.
abstract: The course and characteristics of the different types of bipolar disorder have profound implications for its long-term prognosis and treatment. Patients with bipolar I disorder are symptomatically ill nearly half the time and have a high probability of relapse. Bipolar II disorder is more chronic, more depressive, and associated with more neuroticism and emotional instability between episodes than bipolar I. Impaired psychosocial functioning and a high risk for suicide are common to all types of bipolar disorder. The illness can be stabilized through pharmacotherapy and by patients maintaining orderly patterns of life activities and using psychotherapy, psychoeducation, and mood charting. Adherence to pharmacotherapy increases the duration of remission. Physicians can help improve adherence by selecting medications with simple dosage regimens and educating patients and families about the disorder and what to expect from medications.
authors.affiliation: Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, RI 02906, USA. martin_keller@brown.edu
authors.forename: Martin B
authors.initials: MB
authors.lastname: Keller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use; D001521:Behavior Therapy / Q000379:methods; D001714:Bipolar Disorder / Q000188:drug therapy / Q000523:psychology* / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D019260:Expressed Emotion; D005192:Family Health; D005196:Family Therapy / Q000379:methods; D006266:Health Education / Q000379:methods; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D010349:Patient Compliance; D010353:Patient Education as Topic; D011379:Prognosis; D011613:Psychotherapy; D011619:Psychotropic Drugs / Q000627:therapeutic use; D055502:Secondary Prevention; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D011619:Psychotropic Drugs; D008094:Lithium