title: In vitro effects of four tropical plants on three life-cycle stages of the parasitic nematode, Haemonchus contortus.
abstract: Alcoholic extracts of four tropical plants (Zanthoxylum zanthoxyloides, Newbouldia laevis, Morinda lucida and Carica papaya) were screened in vitro for potential anti-parasitic effects against eggs, infective larvae and adult Haemonchus contortus. Significant effects were obtained with all four plants but differences were observed depending on the parasitic stage. The effects of the four plant extracts were similar on egg hatching and were dose dependent. In contrast, no dose-response relationship was found for infective larvae and adult worms, although more potent effects were usually observed with the highest concentrations. Using a larval inhibition migration test, extracts of fagara (Z. zanthoxyloides) were found to be less active against Haemonchus infective larvae than were the other plants. N. laevis was found to be highly and rapidly effective against adult worms. Overall, these in vitro results suggest that these four plants, traditionally used by small farmers in Western Africa, do possess anti-parasitic properties. These effects remain to be confirmed through in vivo studies.
authors.affiliation: Faculté des Sciences Agronomiques, Université d'Abomey-Calavi, 01 BP 526 Cotonou, Benin.
authors.forename: M S
authors.initials: MS
authors.lastname: Hounzangbe-Adote
authors.forename: V
authors.initials: V
authors.lastname: Paolini
authors.forename: I
authors.initials: I
authors.lastname: Fouraste
authors.forename: K
authors.initials: K
authors.lastname: Moutairou
authors.forename: H
authors.initials: H
authors.lastname: Hoste
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology*; D029402:Bignoniaceae / Q000378:metabolism*; D029441:Carica / Q000737:chemistry*; D006189:Haemonchus / Q000187:drug effects* / Q000254:growth & development; D008018:Life Cycle Stages; D032066:Morinda / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000977:Antiparasitic Agents; D010936:Plant Extracts