A transcriptional profile of aging in the human kidney.
In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age.
Rodwell
Graham E J
GE
Division of Nephrology, Stanford University Medical Center Stanford, California, USA.
Sonu
Rebecca
R
Zahn
Jacob M
JM
Lund
James
J
Wilhelmy
Julie
J
Wang
Lingli
L
Xiao
Wenzhong
W
Mindrinos
Michael
M
Crane
Emily
E
Segal
Eran
E
Myers
Bryan D
BD
Brooks
James D
JD
Davis
Ronald W
RW
Higgins
John
J
Owen
Art B
AB
Kim
Stuart K
SK
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000818:Animals; D001706:Biopsy; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007107:Immune System / Q000473:pathology; D007249:Inflammation; D007668:Kidney / Q000378:metabolism* / Q000473:pathology*; D007672:Kidney Cortex / Q000473:pathology; D007678:Kidney Glomerulus / Q000378:metabolism; D007679:Kidney Medulla / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009132:Muscles / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000378:metabolism; D012044:Regression Analysis; D012737:Sex Factors; D013997:Time Factors; D014158:Transcription, Genetic
D012313:RNA