[Radiation modulating properties of derivates of 1,4-dihydropyridine and 1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8 dione].
First attempt to analyse radiation modifying action of 52 compounds--derivatives of 1,4-dihydropyridine is presented. Many of these compounds have electrodonating and antioxidative activities. Local radioprotective effects of the substances has been studied using experimental model with partial beta- and X-rays exposure of sole skin in rats to doses of 40 and 30 Gy. Comparison of drug effectiveness and chemical structure revealed the changes of activity dependence due to modification of peripheral radicals of 1,4-dihydropyridine ring. Radioprotective and radiosensitizing compounds with general low toxicity have been found. It is suggested to use the most active compounds for the development of medicinal forms for prevention of local skin and mucosal radiation injuries. Positive results have been obtained with dieton a radioprotective compound of the same type, in radiotherapy.
Ivanov
E V
EV
Ponomareva
T V
TV
Merkushev
G N
GN
Romanovich
I K
IK
Dubur
G Ia
GIa
Bisenieks
E A
EA
Uldrikis
Ia R
IaR
Poĭkans
Ia Ia
IaIa
D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D004095:Dihydropyridines / Q000494:pharmacology*; D005260:Female; D008297:Male; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats
C496875:1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione; D000166:Acridines; D004095:Dihydropyridines; D011837:Radiation-Protective Agents; C038806:1,4-dihydropyridine