title: Restoration of antioxidants by ethanolic Tinospora cordifolia in alloxan-induced diabetic Wistar rats.
abstract: The present study investigates the effect of oral administration of an alcoholic extract of Tinospora cordifolia roots on antioxidant defence in alloxan-induced diabetes in rats. A significant increase in the concentration of thiobarbituric acid reactive substances (TBARS) in brain along with a decrease in heart was observed in diabetic rats. Decreased concentration of glutathione (GSH) and decreased activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in heart and brain of diabetic rats were also noted. Alcoholic Tinospora cordifolia root extract (TCREt) administered at a dose of 100 mg/kg to diabetic rats orally for six weeks normalized the antioxidant status of heart and brain. The effect of T. cordifolia root extract was more prominent than glibenclamide (600 microg/kg). Insulin (6 units/kg) restored all the parameters to normal status.
authors.affiliation: Department of Biochemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India.
authors.forename: Ponnaian Stanely Mainzen
authors.initials: PS
authors.lastname: Prince
authors.forename: Narasimhanaidu
authors.initials: N
authors.lastname: Kamalakkannan
authors.forename: Venugopal Padmanabhan
authors.initials: VP
authors.lastname: Menon
mesh_terms: D000496:Alloxan; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D000431:Ethanol; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005905:Glyburide / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D009206:Myocardium / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D031610:Tinospora / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D000431:Ethanol; D000496:Alloxan; D005979:Glutathione Peroxidase; D005978:Glutathione; D005905:Glyburide