Select forms of tumor cell apoptosis induce dendritic cell maturation.
Dendritic cells (DC) play a crucial role in initiating immune responses to tumors. DC can efficiently present antigens from apoptotic tumor cells, but apoptotic cells are thought to lack the inflammatory signals required to induce DC maturation. Here, we show that apoptosis of 67NR mouse carcinoma cells via the Fas (CD95) pathway or induced by the anticancer drug bortezomib (PS-341) but not by ultraviolet irradiation is associated with the production of maturation signals for DC. These data have important implications for the effects of chemotherapy on antitumor immunity in solid and hematologic malignancies.
Demaria
Sandra
S
MSB-563, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. demars01@med.nyu.edu
Santori
Fabio R
FR
Ng
Bruce
B
Liebes
Leonard
L
Formenti
Silvia C
SC
Vukmanovic
Stanislav
S
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D001897:Boronic Acids / Q000494:pharmacology; D000069286:Bortezomib; D045744:Cell Line, Tumor; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D011719:Pyrazines / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology; D019014:fas Receptor / Q000378:metabolism
D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D019014:fas Receptor; D013629:Tamoxifen; C016601:afimoxifene; D000069286:Bortezomib