title: Farinosones A-C, neurotrophic alkaloidal metabolites from the entomogenous deuteromycete Paecilomyces farinosus.
abstract: Two new yellow pigments, farinosones A (1) and B (2), were isolated from the mycelial extract of the entomogenous fungal strain Paecilomyces farinosus RCEF 0101, together with farinosone C (3), a new metabolite derived from an early step of pyridone alkaloid biosynthesis. The structures were determined by spectroscopic means, in particular by extensive NMR experiments. Compounds 1 and 3 induced neurite outgrowth in the PC-12 cell line at concentrations of 50 microM, while compound 2 was inactive. No cytotoxicity was observed for compounds 1-3 in PC-12 cells when tested at 50 microM concentration in the MTT assay.
authors.affiliation: Institute of Pharmacy, Friedrich-Schiller-University Jena, Semmelweisstrasse 10, D-07743 Jena, Germany.
authors.forename: Yongxian
authors.initials: Y
authors.lastname: Cheng
authors.forename: Bernd
authors.initials: B
authors.lastname: Schneider
authors.forename: Ulrike
authors.initials: U
authors.lastname: Riese
authors.forename: Barbara
authors.initials: B
authors.lastname: Schubert
authors.forename: Zengzhi
authors.initials: Z
authors.lastname: Li
authors.forename: Matthias
authors.initials: M
authors.lastname: Hamburger
mesh_terms: D000818:Animals; D002681:China; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D010143:Paecilomyces / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
chemical_list: D009414:Nerve Growth Factors; D010636:Phenols; D010860:Pigments, Biological; D011728:Pyridones; C495160:farinosone A; C495161:farinosone B; C495162:farinosone C