[Comparison of hepatic protein synthesis function between Banna Minipig Inbred Line and human].
OBJECTIVE
This is a research aimed at comparing the hepatic protein synthesis function of Banna Minipig Inbred Line (BMI) with that of human so as to evaluate the possibility of porcine liver replacement of human counterpart.


METHODS
The venous blood samples from BMI and volunteer participants were collected. The albumin and total protein in the separated sera were tested using Beckman delta CX7 autoanalyzer, and serum protein electrophoresis was performed.


RESULTS
No significant differences in albumin and in the percentage and concentration of globulins synthesized in liver (alpha1-, alpha2- and beta-globulin) between BMI and human were observed. The percentage and concentration of gamma-globulin synthesized in the lymphocytes of BMI were significantly higher than those of human.


CONCLUSIONS
The above findings suggested the similarity between BMI liver and human liver in respect to albumin and alpha, beta-globulin synthesis.
Zhang
Lin
L
Lab of Transplant Engineering and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Li
You-ping
YP
Cheng
Jing-qiu
JQ
Peng
Zhi-ying
ZY
Li
Sheng-fu
SF
Zeng
Yang-zhi
YZ
D000510:Alpha-Globulins / Q000032:analysis / Q000302:isolation & purification; D000818:Animals; D017849:Animals, Inbred Strains; D001609:Beta-Globulins / Q000032:analysis / Q000302:isolation & purification; D001798:Blood Proteins / Q000032:analysis*; D004586:Electrophoresis / Q000379:methods; D006801:Humans; D008099:Liver / Q000378:metabolism*; D016031:Liver Transplantation; D008297:Male; D014176:Protein Biosynthesis; D013552:Swine; D013556:Swine, Miniature; D014183:Transplantation, Heterologous; D005719:gamma-Globulins / Q000032:analysis / Q000302:isolation & purification
D000510:Alpha-Globulins; D001609:Beta-Globulins; D001798:Blood Proteins; D005719:gamma-Globulins