Clinically evident venous thromboembolic events in children with brain tumors.
We evaluated the incidence and significance of central venous access device dysfunction and symptomatic major thrombosis in 253 pediatric patients with brain tumors. Central venous access device dysfunction was a common complication (28.4%) and was associated with major thrombosis development and a reduced overall survival rate. Major thrombosis was relatively uncommon (2.8%).
Deitcher
Steven R
SR
Section of Hematology and Coagulation Medicine, Department of Hematology-Medical Oncology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA. sdeitcher@nuvelo.com
Gajjar
Amar
A
Kun
Larry
L
Heideman
Richard L
RL
D001932:Brain Neoplasms / Q000150:complications* / Q000401:mortality / Q000473:pathology; D002405:Catheterization, Central Venous / Q000295:instrumentation / Q000379:methods*; D002648:Child; D004868:Equipment Failure; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D020246:Venous Thrombosis / Q000209:etiology*