[Transport of Mg2+ by Na+-Mg2+ exchange].
Intracellular free Mg(2+) concentration is maintained at low levels by active extrusion from the cells. One of postulated mechanisms is the Na(+)-Mg(2+) exchange, which extrudes Mg(2+) in exchange with Na(+) influx. Although the Na(+)-Mg(2+) exchange activity has been reported in many types of cell, including neurons, details of molecular mechanisms are only poorly understood. In this chapter, we briefly will review our current knowledge on [1] stoichiometry of the Na(+)-Mg(2+) exchange, [2] interaction between the Na(+)-Ca(2+) exchange and the Na(+)-Mg(2+) exchange, [3] molecular biology of the Na(+)-Mg(2+) exchanger.
Konishi
Masato
M
Department of Physiology, Tokyo Medical University.
D000818:Animals; D001692:Biological Transport / Q000502:physiology*; D002413:Cations, Divalent; D017136:Ion Transport / Q000502:physiology*; D007477:Ions; D008274:Magnesium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D002413:Cations, Divalent; D007477:Ions; D012964:Sodium; D008274:Magnesium