title: [Anticancer drugs off label used of: what do the experts think about?].
abstract: Anticancer drugs off label used in Tenon hospital were analysed by a panel of 12 experts not working at Tenon hospital. They distinguished 3 groups of off-label prescribing according to scientific evidence, labelling anticancer drugs alternative in presence and patient's characteristics: justified off label used (62%), unjustified off label used (26%) and prescriptions for which no consensus had been reached between the experts (12%). Nineteen per cent of unjustified off label used had labelling alternative and 7% did not have anticancer drugs labelling alternative. Questions who experts had to answer to analyse drugs prescribing could be systematically asked when a chemotherapy is prescribed. It could allowed to take into account scientific, economic and ethical requirements. This method proposed by the local drug committee could be used to regulate economic resources and to justify financing of some expensive anticancer drugs.
authors.affiliation: Pharmacie, Hôpital Tenon, Paris. isabelle.debris@tnn.ap-hop-paris.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Debrix
authors.forename: Thierry
authors.initials: T
authors.lastname: André
authors.forename: Annie
authors.initials: A
authors.lastname: Becker
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Lotz
authors.forename: Joseph
authors.initials: J
authors.lastname: Gligorov
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Boukari
authors.forename: Bernard
authors.initials: B
authors.lastname: Milleron
authors.forename: Françoise
authors.initials: F
authors.lastname: Pene
authors.forename: Antoine
authors.initials: A
authors.lastname: Flahault
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004348:Drug Labeling; D011307:Drug Prescriptions; D006801:Humans; D008485:Medical Audit; D009369:Neoplasms / Q000188:drug therapy*; D010606:Pharmacy and Therapeutics Committee
chemical_list: D000970:Antineoplastic Agents