title: Anatomically shaped internal carotid artery aneurysm in vitro model for flow analysis to evaluate stent effect.
abstract: OBJECTIVE
  Stent implantation alone might not be sufficient to produce definitive treatment of cerebral aneurysms. Therefore, extended experimental work is needed to improve results. We show the feasibility of using an in vitro anatomically shaped elastic model for flow evaluation before and after stent implantation.
  
  
  METHODS
  Based on human vascular casting, an anatomic elastic internal carotid artery model, including an aneurysm on the supraclinoid portion, was manufactured. The model was connected to a circulatory loop to simulate physiological flow. After visualization of the flow by using glass particles and laser sheet translumination, the digitally recorded data were transferred for computer analysis. Intra-saccular flow pattern changes and the vortex velocity reduction induced by the stent were investigated qualitatively and quantitatively.
  
  
  RESULTS
  The distal neck of the aneurysm behaved as a flow divider. Therefore, it was directly exposed to the hemodynamic stress. Inside the sac, a well-defined vortex formed and progressed along the wall toward the proximal neck. After stent implantation this pattern changed significantly; the vortex appeared more dispersed and its residence time increased. The velocity reduction was 32%. Velocity peak was observed close to the distal neck in both cases.
  
  
  CONCLUSIONS
  In vitro anatomic elastic models are feasible for flow evaluation with laser sheet translumination. In our model, stent implantation resulted in hemodynamic changes that might favor the exclusion of the aneurysm from the circulation and can prevent regrowth of the aneurysmal sac.
authors.affiliation: Department of Radiology, University Hospital of Geneva, Rue Micheli-du-Crest 24, CH-1211 Geneva 14, Switzerland.
authors.forename: Krisztina
authors.initials: K
authors.lastname: Baráth
authors.forename: Francis
authors.initials: F
authors.lastname: Cassot
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Rüfenacht
authors.forename: Jean H D
authors.initials: JH
authors.lastname: Fasel
mesh_terms: D002340:Carotid Artery Diseases / Q000503:physiopathology* / Q000628:therapy*; D002343:Carotid Artery, Internal; D004548:Elasticity; D004867:Equipment Design; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology* / Q000628:therapy*; D008955:Models, Cardiovascular; D012039:Regional Blood Flow; D015607:Stents