title: Review article: orofacial granulomatosis.
abstract: Orofacial granulomatosis is an uncommon clinicopathological entity describing patients who have oral lesions characterized by persistent and/or recurrent labial enlargement, oral ulcers and a variety of other orofacial features, who on lesional biopsy have lymphoedema and non-caseating granulomas. The aetiology of oral lesions with non-caseating granulomas includes oral Crohn's disease (some patients with oral lesions will develop typical bowel symptoms of Crohn's disease in ensuing months to years), tooth-associated infections, sarcoidosis and food or contact allergies. Treatment of orofacial granulomatosis is not reliably effective and may not be always necessary, although most patients do require some medical intervention.
authors.affiliation: Departamento de Clinica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, PE, Brazil.
authors.forename: J C
authors.initials: JC
authors.lastname: Leão
authors.forename: T
authors.initials: T
authors.lastname: Hodgson
authors.forename: C
authors.initials: C
authors.lastname: Scully
authors.forename: S
authors.initials: S
authors.lastname: Porter
mesh_terms: D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D006099:Granuloma / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D006801:Humans; D009059:Mouth Diseases / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D012008:Recurrence