The polymorphisms of Tim-1 promoter region are associated with rheumatoid arthritis in a Korean population.
It has been determined that the family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is expressed on T cells. A member of the TIM family, TIM-1, is considered to be a membrane protein associated with the development of Th2-biased immune responses and selectively expressed on Th2 cells. We previously showed that the exon 4 variations of Tim-1 are associated with susceptibility to allergic diseases, as well as autoimmune diseases such as rheumatoid arthritis (RA). In this study, we assessed the association between genotype and allele frequencies of the Tim-1 gene promoter region, in both RA patients and the controls without RA, using polymerase chain reaction-restriction fragment length polymorphism and single-base extension methods. We further investigated the relationships among the genotypes of each polymorphism and C-reactive protein or rheumatoid factor levels in RA patients. The genotype and allele frequencies of the -1637A>G polymorphism in RA patients are significantly different from those in the non-RA controls (P=0.0004 and P=0.001, respectively). Our results strongly suggest that polymorphism in the Tim-1 promoter region might be associated with susceptibility to RA.
Chae
Soo-Cheon
SC
Genome Research Center for Immune Disorders, Wonkwang University School of Medicine, Iksan, Chonbuk, 570-749, Korea.
Park
Young-Ran
YR
Song
Ju-Hee
JH
Shim
Seung-Cheol
SC
Yoon
Kyung-Sik
KS
Chung
Hun-Taeg
HT
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D044466:Asian People; D005260:Female; D005786:Gene Expression Regulation; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011991:Receptors, Virus / Q000235:genetics*
C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus