title: MIC quality control guidelines for doxycycline when testing gram-positive control strains by the reference methods.
abstract: With emerging resistance to fluoroquinolones, there arises a need to establish quality control (QC) guidelines for doxycycline, an effective alternative for treating various community-acquired respiratory tract infections. This multicenter study was performed to establish QC guidelines for susceptibility testing those Gram-positive QC organisms against doxycycline. The proposed three or four log2 dilution MIC ranges included 100.0% of the doxycycline MIC values reported.
authors.affiliation: The JONES Group/JMI Laboratories, North Liberty, IA, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Ross
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004318:Doxycycline / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D013293:Enterococcus faecalis / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011786:Quality Control; D012015:Reference Standards; D013211:Staphylococcus aureus / Q000187:drug effects*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline