title: Molluscicidal activity of synthetic lapachol amino and hydrogenated derivatives.
abstract: A series of new amino derivatives and a new partially hydrogenated derivative of the natural naphthoquinone lapachol were assayed for molluscicidal activity against Biomphalaria glabrata. These derivatives showed low to medium LC(50) values, and a 3.1 microg/mL value for the most potent derivative of the series. The toxicity is in agreement with the decrease of polar character of the tested compounds.
authors.affiliation: Laboratório de Tecnologia Farmacêutica, LTF-UFPB, Campus I, Cidade Universitária, 58051-970 João Pessoa, PB, CP 5009, Brazil. sarmento@ltf.ufpb.br
authors.forename: Tania M S
authors.initials: TM
authors.lastname: Silva
authors.forename: Celso A
authors.initials: CA
authors.lastname: Camara
authors.forename: Ticiano P
authors.initials: TP
authors.lastname: Barbosa
authors.forename: André Z
authors.initials: AZ
authors.lastname: Soares
authors.forename: Luciana C
authors.initials: LC
authors.lastname: da Cunha
authors.forename: Angelo C
authors.initials: AC
authors.lastname: Pinto
authors.forename: Maria D
authors.initials: MD
authors.lastname: Vargas
mesh_terms: D000588:Amines / Q000737:chemistry; D000818:Animals; D006859:Hydrogen / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008974:Mollusca / Q000187:drug effects*; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000588:Amines; D009285:Naphthoquinones; D006859:Hydrogen; C008252:lapachol