[Non-histaminic angiodema management: diagnostic and therapeutic interest of tranexamic acid].
BACKGROUND
The diagnosis of chronic angioedema (localised and reversible oedema) is sometimes very difficult when there is no efficiency of anti-histaminics and corticosteroids. In these cases, bradykinin angioedema must be mentioned. Tranexamic acid is efficient and must be proposed.


METHODS
We reported seven patients who have a non-histaminergic angioedema since an average of 8 years. Corticosteroids and histamine-1 blockers were not efficient. Daily tranexamic acid treatment (1 g x 3 per day) controlled the disease. Three patients had no more attack. The C1Inh antigen and function levels were normal. No secondary effect was described and all patients are still being treated (average of 20 months).


CONCLUSIONS
When a non-histaminergic angioedema is suspected, tranexamic acid must be proposed as attack's treatment and as prophylactic treatment.
Bouillet
L
L
Service de médecine interne, département pluridisciplinaire de médecine, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France. lbouilletclaveyrolas@chu-grenoble.fr
Ponard
D
D
Drouet
C
C
Massot
C
C
D000293:Adolescent; D000328:Adult; D000799:Angioedema / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D014148:Tranexamic Acid / Q000627:therapeutic use*
D014148:Tranexamic Acid