Epstein-Barr virus lymphoproliferative disorders after liver transplantation.
Post-transplant lymphoproliferative disorders (PTLD) represent a spectrum of histological and immunological abnormalities, ranging from benign polyclonal B-cell hyperplasia to monoclonal malignant lymphoma. The important role of Epstein-Barr virus (EBV) in PTLD in liver transplant patients, particularly in pediatric recipients, is reviewed. Understanding the risks of EBV infection, the clinical presentations and diagnosis of PTLD, and its pathophysiology are crucial to the management of these disorders. Current treatment methods have resulted in better outcomes of these disorders, which in the past were uniformly fatal.
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Multi-Organ Transplant Center, Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
Cox
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D000328:Adult; D000367:Age Factors; D002648:Child; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D004854:Herpesvirus 4, Human; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000628:therapy* / Q000821:virology*; D016896:Treatment Outcome