The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.
In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae. However, the in vitro phenotypes of C. albicans crz1/crz1 and calcineurin mutants differ and Crz1 is not required for virulence.
Onyewu
Chiatogu
C
Department of Molecular Genetics and Microbiology, 322 Carl Building, Box 3546, Research Drive, Duke University Medical Center, Durham, NC 27710, USA.
Wormley
Floyd L
FL
Perfect
John R
JR
Heitman
Joseph
J
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D019703:Calcineurin / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000472:pathogenicity*; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D016559:Tacrolimus / Q000494:pharmacology
D000935:Antifungal Agents; D015725:Fluconazole; D019703:Calcineurin; D016559:Tacrolimus