Meiotic recombination: sealing the partnership at the junction.
Crossovers ensure proper chromosome segregation in meiosis. A heterodimer of MutS proteins, hMSH4-hMSH5, has recently been found to interact with recombination intermediates in a manner that suggests a mechanism for directing meiotic DNA double strand break repair towards a crossover pathway.
Kunz
Christophe
C
Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, University of Basel, Switzerland.
Schär
Primo
P
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism; D020090:Chromosome Segregation / Q000502:physiology*; D003434:Crossing Over, Genetic / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D045566:DNA, Cruciform / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism*; D008540:Meiosis / Q000502:physiology*; D051719:MutS DNA Mismatch-Binding Protein; D011506:Proteins / Q000378:metabolism
D001426:Bacterial Proteins; D018797:Cell Cycle Proteins; D045566:DNA, Cruciform; D004268:DNA-Binding Proteins; C409221:MSH4 protein, human; D011506:Proteins; D000251:Adenosine Triphosphatases; D051719:MutS DNA Mismatch-Binding Protein