ACR classification criteria for systemic lupus erythematosus: complement components.
Complement is involved in the pathogenesis of systemic lupus erythematosus (SLE) and has also a seemingly paradoxical protective role in the development of the disease. Low levels of components within the classical pathway of complement especially C1q, C4 and C3 have a high specificity for SLE diagnosis and should be considered as promising for inclusion in classification criteria of SLE.
Nived
O
O
Department of Rheumatology, University Hospital, Sweden.
Sturfelt
G
G
D015415:Biomarkers / Q000032:analysis; D015922:Complement C1q / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000145:classification / Q000175:diagnosis*
D015415:Biomarkers; D015922:Complement C1q; D003165:Complement System Proteins