Successful liver transplantation in a patient with severe haemophilia A and a high-titre factor VIII inhibitor.
We present the case of a 61-year-old man with severe haemophilia A and a high-titre factor VIII inhibitor who underwent successful orthotopic liver transplantation (OLT) for hepatocellular carcinoma. Postoperatively, a modest early anamnestic response to FVIII was followed by immunological tolerance to FVIII. This case illustrates the technical feasibility of OLT in some patients with high-titre inhibitors to FVIII, and suggests that immune tolerance may be induced by endogenously produced FVIII from the transplanted organ.
Ashrani
A A
AA
Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Reding
M T
MT
Shet
A
A
Osip
J
J
Humar
A
A
Lake
J R
JR
Key
N S
NS
D016063:Blood Loss, Surgical / Q000517:prevention & control; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D005240:Feasibility Studies; D006467:Hemophilia A / Q000628:therapy*; D019698:Hepatitis C, Chronic / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged
D005169:Factor VIII