[Direct effects of vitamin D on bone].
Many investigators used to believe that active vitamin D is a promotive factor for bone resorption. However, active vitamin D shows an osteoprotective action when administrated as an anti-osteoporotic agent. Recently, active vitamin D agents are considered as an inhibitor for bone resorption. However, it is difficult to evaluate if it is also the case in chronic renal failure, since high-turnovered osteopenia found in uremic patients are brought about by secondary hyperparathyroidism.
Kazama
Junichiro James
JJ
Division of Intensive Care Medicine, Niigata University Medical and Dental Hospital.
D000818:Animals; D001851:Bone Diseases, Metabolic / Q000188:drug therapy / Q000209:etiology; D001862:Bone Resorption / Q000188:drug therapy; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000188:drug therapy; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000188:drug therapy / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism; D010010:Osteoclasts / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy; D010281:Parathyroid Hormone / Q000378:metabolism; D014807:Vitamin D / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use*
D010281:Parathyroid Hormone; D014807:Vitamin D; D002118:Calcium