Effect of inactivation of the HtrA-like serine protease DegQ on the virulence of Salmonella enterica serovar Typhimurium in mice.
DegQ is a serine protease that is highly homologous to HtrA, an important virulence determinant of Salmonella enterica serovar Typhimurium. We examined if DegQ is involved in serovar Typhimurium pathogenesis. A serovar Typhimurium degQ mutant was as virulent as the wild-type strain in mice. However, a serovar Typhimurium htrA degQ mutant survived less well in murine organs, particularly in the liver, than a serovar Typhimurium htrA mutant. DegQ is not essential for serovar Typhimurium pathogenesis but may play a small role during salmonella growth at systemic sites.
Farn
Jacinta
J
Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, United Kingdom.
Roberts
Mark
M
D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D012486:Salmonella typhimurium / Q000472:pathogenicity*; D012697:Serine Endopeptidases / Q000502:physiology*; D014774:Virulence
D001426:Bacterial Proteins; D012697:Serine Endopeptidases