Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase.
An HTS campaign aimed at the identification of inhibitors of HIV integrase showed that the methanol extract from the buds of a Eucalyptus globoidea was active. Bioassay guided fractionation of this extract resulted in the purification and structural elucidation of the lignan, globoidnan A (1) as the only compound in the extract responsible for the inhibition of HIV integrase. The compound was found to inhibit the combined 3' processing and strand transfer activity of HIV integrase with an IC50=0.64 microM.
Ovenden
Simon P B
SP
Cerylid Biosciences Ltd., 576 Swan Street, Richmond, Vic. 3121, Australia.
Yu
Jin
J
Wan
Soo San
SS
Sberna
Gian
G
Tait
R Murray
RM
Rhodes
David
D
Cox
Susan
S
Coates
Jonathan
J
Walsh
Neville G
NG
Meurer-Grimes
Barbara M
BM
D005052:Eucalyptus / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D019428:HIV Integrase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000201:enzymology; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure
D019428:HIV Integrase Inhibitors; D017705:Lignans; C496759:globoidnan A