title: Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects.
abstract: Adiponectin is an adipocyte-secreted protein that is known to modulate insulin sensitivity and glucose homeostasis. A number of genetic variations have been studied. Among them, two single-nucleotide polymorphisms (SNP45T>G, SNP276G>T) showed an association with type 2 diabetes in the Japanese population. In this study, we examined the association between these SNPs and risk factors of type 2 diabetes in 194 non-diabetic Japanese subjects. SNP45 was associated with insulin sensitivity (determined by HOMA-IR, p=0.046) and obesity (body mass index; BMI, p=0.043). SNP276 showed a stronger association with HOMA-IR (p=0.018) and BMI (p=0.017). However, neither SNP had an association with insulin secretion (insulinogenic index) and plasma lipid levels. Moreover, a linkage dis-equilibrium was observed between SNP45 and SNP276. Carriers with SNP45G-SNP276G haplotype had higher BMI (p=0.034) and carriers with SNP45T-SNP276T haplotype had lower BMI (p=0.005) and HOMA-IR (p=0.037). Adiponectin gene variations showed an association with obesity and insulin sensitivity, and adiponectin genotypes may predict the increasing risk for type 2 diabetes in non-diabetic subjects.
authors.affiliation: Department of Laboratory Medicine, Mie University School of Medicine, Edobashi 2-174, Tsu, Mie 514-8507, Japan. nakatani@clin.medic.mie-u.ac.jp
authors.forename: Kaname
authors.initials: K
authors.lastname: Nakatani
authors.forename: Katsura
authors.initials: K
authors.lastname: Noma
authors.forename: Junji
authors.initials: J
authors.lastname: Nishioka
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Kasai
authors.forename: Kohei
authors.initials: K
authors.lastname: Morioka
authors.forename: Akira
authors.initials: A
authors.lastname: Katsuki
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Hori
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yano
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Sumida
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nobori
mesh_terms: D052242:Adiponectin; D044466:Asian People / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins