title: [Additional effect of SERM: central nervous system].
abstract: Raloxifene is a selective estrogen-receptor modulator recently launched in Japan as a new medicine for treatment of postmenopausal osteoporosis. Raloxifene stimulates neurite outgrowth in cultured cells and increases hippocampal cholineacethyl trasferase activity and serotonin receptor in the brain of ovariectomized rats. As a part of the Multiple Outcomes of Raloxifene Evaluation trial, 7,478 postmenopausal women with osteoporosis were studied by using six tests of cognitive function. There was some evidence that Raloxifene may lower the risk of a decline in memory and attention. It is expected that novel SERM, which has more specific efficacy improving cognitive function will be developed.
authors.affiliation: Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science.
authors.forename: Hideo
authors.initials: H
authors.lastname: Honjo
mesh_terms: D001288:Attention / Q000187:drug effects; D002478:Cells, Cultured; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003071:Cognition / Q000187:drug effects*; D005260:Female; D006624:Hippocampus / Q000201:enzymology; D006801:Humans; D008568:Memory / Q000187:drug effects*; D016501:Neurites / Q000187:drug effects; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy / Q000523:psychology; D020849:Raloxifene Hydrochloride / Q000494:pharmacology* / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D011985:Receptors, Serotonin / Q000378:metabolism; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology* / Q000627:therapeutic use*; D013268:Stimulation, Chemical
chemical_list: D011985:Receptors, Serotonin; D020845:Selective Estrogen Receptor Modulators; D020849:Raloxifene Hydrochloride; D002795:Choline O-Acetyltransferase