title: [A role of depression in chronic dorsalgia: approaches to therapeutic correction].
abstract: An impact of depression on general clinical picture was studied in 20 patients with chronic dorsalgia, who were treated with coaxil. Along with complaints to prolonged back pains, patients featured by high depression and anxiety, sleep disturbances, autonomic dysfunction and marked decrease of quality of life. Psychometric tests revealed a presence of depressive symptoms in 90% of the cases. All patients were treated with coaxil in dosage 12.5 mg 3 times daily during 6 weeks. The treatment allowed a reduction of depression and anxiety symptoms, along with muscle dysfunction and pain syndrome. Positive dynamics of autonomic dysfunction, sleep disturbances and quality of life was observed already at the initial treatment stage. The results of the study confirm the fact that depression develops in patients with chronic dorsalgia, influencing negatively on the course of pain syndrome. Coaxil was shown to have high efficacy and safety in the treatment of depression caused by chronic back pain and positively influence on the main syndrome.
authors.forename: O V
authors.initials: OV
authors.lastname: Vorob'eva
authors.forename: E S
authors.initials: ES
authors.lastname: Akarachkova
mesh_terms: D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D001416:Back Pain / Q000175:diagnosis / Q000523:psychology*; D002908:Chronic Disease; D003863:Depression / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011594:Psychometrics; D013841:Thiazepines / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine