title: Construction of optically active CF3-containing quaternary carbon centers via stereospecific S(N)2' reaction.
abstract: [reaction: see text] Phosphates from 3-substituted 4,4,4-trifluorobut-2-en-1-ols were found to be effective for construction of CF3-containing quaternary carbon centers by way of Cu(I)-catalyzed Grignard reactions in the presence of catalytic amounts of CuCN and trimethylsilyl chloride (TMSCl) in an anti S(N)2' manner.
authors.affiliation: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kitazume
authors.forename: Toshio
authors.initials: T
authors.lastname: Kubota