title: Endophytic naphthopyrone metabolites are co-inhibitors of xanthine oxidase, SW1116 cell and some microbial growths.
abstract: Fractionation of the extract of Aspergillus niger. IFB-E003, an endophyte in Cyndon dactylon, gave four known compounds naphtho-gamma-pyrones rubrofusarin B, fonsecinone A, asperpyrone B and aurasperone A, which were further investigated biologically. Rubrofusarin B was shown to be cytotoxic to the colon cancer cell line SW1116 (IC50: 4.5 microgml-1), and aurasperone A inhibitory on XO (xanthine oxidase) (IC50: 10.9 micromoll-1). Moreover, the four naphtho-gamma-pyrones exhibited growth inhibitions against the five test microbes with MICs ranging in between 1.9 and 31.2 microgml(-1). The present recognition of rubrofusarin B and aurasperone A as strong co-inhibitors on XO, colon cancer cell and some microbial pathogens is of significance for the imperative discovery of new relevant therapeutic agents.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
authors.forename: Y C
authors.initials: YC
authors.lastname: Song
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: Y H
authors.initials: YH
authors.lastname: Ye
authors.forename: C Y
authors.initials: CY
authors.lastname: Shan
authors.forename: Y M
authors.initials: YM
authors.lastname: Yang
authors.forename: R X
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001234:Aspergillus niger / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D011753:Pyrones / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D011753:Pyrones; C015497:rubrofusarin; D014969:Xanthine Oxidase