title: [Functional and morphological characterization of rat thyroid gland at remote periods following single high and low dose radiation exposure].
abstract: A study of the morphological structure and functional activity of the rat thyroid gland was carried out after 22 months following a single exposure to external radiation. The 3-month-old animals were irradiated with doses of 0.25, 0.5, 1.0, 2.0 and 5.0 Gy. Blood was assayed for thyroxin (T4) and triiodothyronine (T3) levels, while liver tissue--for NADP-MDH activity and thyroid tissue--for thyroperoxidase activity. The thyroid was studied histologically, morphometrically and by electron microscope. The decreased T4 concentrations 2.59-fold in the 5.0 Gy group, the increased T3/T4 in the 2.0 and 0.25 Gy groups, the reduced diameter of cellular nuclei and follicles, the flat follicular epithelium and diminished number of thyrocyte ultrastructures indicate thyroid hypofunction in the irradiated animals. The morphological changes are characterized by enhanced diffuse and focal sclerotic changes in thyroid, most pronounced at high irradiation doses (1.0-5.0 Gy), whereas the hemosiderosis foci suggest that the structural changes are consequences of radiation-induced destructive injuries in the gland parenchyma. Two of the thyroids (0.5 Gy) demonstrate foci with pronounced lymphoid infiltration, while follicular carcinomas were detected in 4 thyroids (2.0 Gy), and in one thyroid (0.5 Gy) in one thyroid (5.0 Gy). The remote effects of radiation were dose-dependent destructive, sclerotic and atrophic processes, decreased functional activity, stimulation of development of autoimmune aggression and carcinogenesis in thyroid.
authors.forename: L I
authors.initials: LI
authors.lastname: Nadol'nik
authors.forename: Z V
authors.initials: ZV
authors.lastname: Netsetskaia
authors.forename: N A
authors.initials: NA
authors.lastname: Kardash
authors.forename: D I
authors.initials: DI
authors.lastname: Martynchik
authors.forename: R I
authors.initials: RI
authors.lastname: Kravchuk
authors.forename: V A
authors.initials: VA
authors.lastname: Basinskiĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Vinogradov
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007453:Iodide Peroxidase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000473:pathology / Q000502:physiology / Q000528:radiation effects* / Q000648:ultrastructure; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000378:metabolism
chemical_list: D014284:Triiodothyronine; D007453:Iodide Peroxidase; D013974:Thyroxine