title: Allergy to cocamidopropyl betaine and amidoamine in North America.
abstract: BACKGROUND
  The prevalence of allergy to cocamidopropyl betaine (CAPB) in North America has not been previously reported.
  
  
  OBJECTIVE
  The aim of this study was to report on the most recent data on allergy to CAPB and a related allergen, amidoamine (AA).
  
  
  METHODS
  Data was collected by the North American Contact Dermatitis Group from consecutive patients presenting for patch testing for diagnosis of presumed allergic contact dermatitis (ACD) from January 1, 2001, through December 31, 2001.
  
  
  RESULTS
  Of 975 patients tested, 15 were patch-test positive to CAPB, 25 had positive reactions to AA, and 18 had positive reactions to both CAPB and AA. The most frequent site of dermatitis from CAPB was the head and neck region.
  
  
  CONCLUSIONS
  In North America, both CAPB and AA are useful allergens for detecting ACD.
authors.affiliation: North American Contact Dermatitis Group, USA.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Fowler
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Zug
authors.forename: James S
authors.initials: JS
authors.lastname: Taylor
authors.forename: Frances J
authors.initials: FJ
authors.lastname: Storrs
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Sherertz
authors.forename: Denis A
authors.initials: DA
authors.lastname: Sasseville
authors.forename: Robert L
authors.initials: RL
authors.lastname: Rietschel
authors.forename: Melanie D
authors.initials: MD
authors.lastname: Pratt
authors.forename: C G Toby
authors.initials: CG
authors.lastname: Mathias
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.forename: Howard I
authors.initials: HI
authors.lastname: Maibach
authors.forename: Anthony F
authors.initials: AF
authors.lastname: Fransway
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Deleo
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
mesh_terms: D000485:Allergens / Q000009:adverse effects*; D000588:Amines / Q000009:adverse effects*; D001622:Betaine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D005148:Facial Dermatoses / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008499:Medical Records; D010328:Patch Tests; D015995:Prevalence; D012189:Retrospective Studies; D013501:Surface-Active Agents / Q000009:adverse effects*; D014481:United States / Q000453:epidemiology
chemical_list: D000485:Allergens; D000588:Amines; D013501:Surface-Active Agents; D001622:Betaine; C077055:cocamidopropyl betaine