Haemostatic alterations in colorectal cancer: perspectives for future treatment.
The role of the haemostatic system in colorectal cancer (CRC) is reviewed. Correlations between the activation of the haemostatic system and overall survival have been suggested. Experimental studies indicate that the haemostatic system plays a key role in growth, invasion and dissemination of tumour cells, and in tumour related angiogenesis. Additional activation by the surgical trauma and postoperative infections are discussed. Finally, anti-cancer modalities directed against regulation of the haemostatic system in CRC are considered.
Lykke
Jakob
J
Surgical Immunology Laboratory, Department of Surgical Gastroenterology, Hvidovre University Hospital, Copenhagen, Denmark. jly@dadlnet.dk
Nielsen
Hans Jørgen
HJ
D000818:Animals; D001777:Blood Coagulation; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D007239:Infections / Q000209:etiology; D010447:Peptide Hydrolases / Q000502:physiology; D011183:Postoperative Complications; D013925:Thromboplastin / Q000378:metabolism; D020246:Venous Thrombosis / Q000209:etiology
D013925:Thromboplastin; D010447:Peptide Hydrolases