The transcription machinery in mammalian mitochondria.
Initiation of transcription at mitochondrial promoters in mammalian cells requires the simultaneous presence of a monomeric mitochondrial RNA polymerase, mitochondrial transcription factor A, and either transcription factor B1 or B2. We here review recent progress in our understanding of how these basal factors cooperate in the initiation and regulation of mitochondrial transcription. We describe the evolutionary origin of individual transcription factors and discuss how these phylogenetic relationships may facilitate a molecular understanding of the mitochondrial transcription machinery.
Gaspari
Martina
M
Department of Medical Nutrition, Karolinska Institute, Novum, SE-141 86 Stockholm, Sweden.
Larsson
Nils-Göran
NG
Gustafsson
Claes M
CM
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D006801:Humans; D008322:Mammals / Q000235:genetics*; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D024101:Mitochondrial Proteins; D009687:Nuclear Proteins; C499631:TFAM protein, human; C499632:TFB1M protein, human; C462442:Tfb2m protein, mouse; D014157:Transcription Factors; C422562:mitochondrial transcription factor A; D012321:DNA-Directed RNA Polymerases