Milia in regressing plaques of mycosis fungoides: provoked by topical nitrogen mustard or not?
OBJECTIVE
To report three cases of mycosis fungoides with milia formation in the regressing lesions.


METHODS
Dermatology clinic of a university hospital (referral center). Three patients with mycosis fungoides with body surface involvement of 10% in one case (stage IIb) and exceeding 30% in two cases (stages IIb and III). All patients were treated with photochemotherapy and topical nitrogen mustard ointment in a concentration of 0.01%. After approximately 3 months multiple milia erupted on regressing plaques.


RESULTS
The presence of milia was evident and was confirmed by histopathology. Regression of mycosis fungoides was noted in these plaques both clinically and in comparison with the pretreatment histologic appearance. Two of the patients showed a histological picture of follicular mucinosis.


CONCLUSIONS
We do not know the significance of milia in mycosis fungoides (MF). However, we suggest that follicular rupture or a degenerative process might result in milia formation.
Kalayciyan
Aylin
A
Department of Dermatology, University of Istanbul, Istanbul, Turkey. drkalayciyan@yahoo.com
Oguz
Oya
O
Demirkesen
Cuyan
C
Serdaroglu
Server
S
Kotogyan
Agop
A
D000279:Administration, Cutaneous; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D004814:Epidermal Cyst / Q000209:etiology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000627:therapeutic use*; D008875:Middle Aged; D000507:Mucinosis, Follicular / Q000209:etiology / Q000473:pathology; D009182:Mycosis Fungoides / Q000188:drug therapy*; D010778:Photochemotherapy; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
D018906:Antineoplastic Agents, Alkylating; D008466:Mechlorethamine