[Correlation between DNA load of human papillomavirus and recurrence of condyloma acuminata].
OBJECTIVE
To determine the correlation between DNA load of human papillomavirus (HPV) and recurrence of condyloma acuminata (CA).


METHODS
The HPV6/11 and HPV16/18 DNA load of 31 cases of primary CA and 32 cases of recurrent CA were detected by real-time fluorogenic quantitative PCR.


RESULTS
Among the 63 CA patients, 62 cases were HPV6/11 DNA positive. The positive rate was 98.4%. The ranges of HPV6/11 DNA load in primary and recurrent CA were 1.4x10(3)-6.7x10(7) copies/ml and 1.2x10(4)-3.6x10(8) copies/ml respectively. Of 62 cases with HPV6/11 DNA positive, 7 cases were HPV16/18 DNA positive (11.3%). The ranges of HPV16/18 DNA load in primary and recurrent CA were 1.9x10(3)-1.6x10(4) copies/ml and 1.4x10(5)-1.7x10(7) copies/ml respectively. The HPV6/11 and HPV16/18 DNA load in recurrent CA were higher than in primary CA (P < 0.05). The DNA load of HPV6/11 was positively correlated with times of recurrence and course of disease (r=0.37 and 0.30 respectively).


CONCLUSIONS
Certain correlation exists between DNA load of HPV and recurrence of CA.
Che
Ya-min
YM
Department of Dermatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Wang
Jia-bi
JB
Zuo
Ya-gang
YG
Liu
Yue-hua
YH
D000328:Adult; D003218:Condylomata Acuminata / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000821:virology*; D012008:Recurrence; D017422:Sequence Analysis, DNA; D019562:Viral Load
D004279:DNA, Viral