title: [Familial multiple sclerosis in Canary Islands].
abstract: BACKGROUND
  Multiple sclerosis (MS) is an autoimmune disease that occurs in genetically predisposed individuals. Its inheritance is polygenic. Genetic epidemiology studies have shown an increased familial aggregation. AIM. To determine the prevalence of familial MS (fMS) in a series of patients from the Canary Islands.
  
  
  METHODS
  From a cohort of 266 patients with defined MS, during a 6-year period, we investigated prospectively by personal interviews the presence of MS on first and second degree relatives. We analysed as well the presence of HLA DRB1 in affected families, and also clinical and demographic characteristics in fMS and compared them with sporadic MS (sMS).
  
  
  RESULTS
  fMS prevalence was 13.9% (27 non-related families with 50 affected individuals). The HLA DRB01*1501 allele were present in 51,8% of familial cases. We could not found either intrafamilial concordance in clinically affected regions and age of onset or clinical evolution. We have not found any phenotypic differences between familial and sMS.
  
  
  CONCLUSIONS
  The prevalence of fMS in our series is comparable to that in other Mediterranean populations. Our results do not support that fMS was a different clinical entity of sMS and intrafamilial concordance in its clinical expression.
authors.affiliation: Servicio de Neurología, Hospital de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Amela-Peris
authors.forename: Y
authors.initials: Y
authors.lastname: Aladro
authors.forename: M A
authors.initials: MA
authors.lastname: Conde-Sendín
authors.forename: M J
authors.initials: MJ
authors.lastname: Alemany-Rodríguez
authors.forename: C
authors.initials: C
authors.lastname: Muñoz-Fernández
authors.forename: M P
authors.initials: MP
authors.lastname: Reyes-Yáñez
authors.forename: M C
authors.initials: MC
authors.lastname: Déniz-Naranjo
authors.forename: F
authors.initials: F
authors.lastname: Sánchez-García
mesh_terms: D000293:Adolescent; D000328:Adult; D001266:Atlantic Islands / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C489631:HLA-DRB1*15:01 antigen