title: Relationship of serum osteoprotegerin levels with coronary artery disease severity, left ventricular hypertrophy and C-reactive protein.
abstract: OPG (osteoprotegerin) is an inhibitor of osteoclastogenesis and recent work suggests it has a role in atherosclerosis. Therefore we measured serum OPG levels in patients with coronary artery disease, compared the serum OPG levels among the different groups according to the number of stenotic vessels and determined whether there was any correlation with aortic calcification, LV (left ventricular) mass index and serum CRP (C-reactive protein) levels. Subjects (n=100; mean age, 57 years) who underwent coronary angiograms were enrolled. Blood pressure, body mass index, fasting blood glucose, lipid profiles and CRP levels were measured and the LV mass indices were calculated using ECGs. Serum OPG levels were measured by ELISA. The presence of calcification in the aortic notch was checked by a chest X-ray. The subjects were divided into four groups according to the number of stenotic vessels. The mean serum OPG levels increased significantly as the number of stenotic vessels increased, and the mean serum OPG levels were higher in the group with three-vessel disease compared with the groups with no- or one-vessel disease. The mean serum CRP level was significantly higher in the group with three-vessel disease compared with the groups with no-, one- and two-vessel disease. Age and LV mass index showed significant positive correlations with serum OPG levels, although significance was lost after an adjustment for age. Serum CRP levels were positively correlated with serum OPG levels even after an adjustment for age. There were no differences in serum OPG levels according to the presence of fasting hyperglycaemia or aortic calcification. In conclusion, serum OPG level was related to the severity of stenotic coronary arteries and serum CRP levels. LV mass indices showed no significant correlation with OPG levels. The precise mechanism for the role of OPG in atherosclerosis needs to be investigated further.
authors.affiliation: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Pyung-dong, Seoul 110-746, South Korea.
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Rhee
authors.forename: Won-Young
authors.initials: WY
authors.lastname: Lee
authors.forename: Se-Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Byung-Jin
authors.initials: BJ
authors.lastname: Kim
authors.forename: Ki-Chul
authors.initials: KC
authors.lastname: Sung
authors.forename: Bum-Su
authors.initials: BS
authors.lastname: Kim
authors.forename: Jin-Ho
authors.initials: JH
authors.lastname: Kang
authors.forename: Ki-Won
authors.initials: KW
authors.lastname: Oh
authors.forename: Eun-Sook
authors.initials: ES
authors.lastname: Oh
authors.forename: Ki-Hyun
authors.initials: KH
authors.lastname: Baek
authors.forename: Moo-Ii
authors.initials: MI
authors.lastname: Kang
authors.forename: Hee-Yeon
authors.initials: HY
authors.lastname: Woo
authors.forename: Hyo-Soon
authors.initials: HS
authors.lastname: Park
authors.forename: Sun-Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Man-Ho
authors.initials: MH
authors.lastname: Lee
authors.forename: Jung-Roe
authors.initials: JR
authors.lastname: Park
mesh_terms: D000368:Aged; D001027:Aortography; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002114:Calcinosis / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D018450:Disease Progression; D004562:Electrocardiography; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D008875:Middle Aged; D053244:Osteoprotegerin; D018160:Receptors, Cytoplasmic and Nuclear / Q000097:blood*; D018124:Receptors, Tumor Necrosis Factor
chemical_list: D015415:Biomarkers; D006023:Glycoproteins; D053244:Osteoprotegerin; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; C506030:TNFRSF11B protein, human; D002097:C-Reactive Protein