[Mechanism and therapy of vascular calcification].
Vascular calcification is clinically important, because it predicts a higher risk of cardiovascular event. Its pathogenesis involve atherosclerosis and regulated by mechanism which like bone metabolism. In dialysis patients, there is excess oxidative stress, shortage of scavenger, metabolic abnormality of calcium and phosphate. These factors may accelerate vascular calcification in dialysis patient. K/DOQI guideline shows the therapeutic strategy for calcium and phosphate metabolic abnormality. It is expected more progression in therapy for vascular calcification.
Hara
Shino
S
Division of kidney and hypertension, Department of Internal Medicine, Jikei University School of Medicine.
Yokoyama
Keitaro
K
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002114:Calcinosis / Q000209:etiology* / Q000378:metabolism / Q000628:therapy*; D002118:Calcium / Q000378:metabolism; D004852:Epoxy Compounds / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress; D010710:Phosphates / Q000378:metabolism; D011073:Polyamines; D011095:Polyethylenes / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D006435:Renal Dialysis / Q000009:adverse effects; D000069603:Sevelamer; D020521:Stroke / Q000209:etiology; D014652:Vascular Diseases / Q000209:etiology* / Q000378:metabolism / Q000628:therapy*
D000975:Antioxidants; D004852:Epoxy Compounds; D016166:Free Radical Scavengers; D010710:Phosphates; D011073:Polyamines; D011095:Polyethylenes; D000069603:Sevelamer; D002118:Calcium