title: Virilisation in a case of transitional cell carcinoma of the ovary.
abstract: A 52 year old woman presented with a five month history of emotional changes, voice changes, and of abdominal discomfort. Clinical, biochemical, and radiological examinations showed evidence of virilisation, raised testosterone, and a complex ovarian mass. Microscopy of the resection specimen showed the tumour to be a transitional cell carcinoma of the ovary with luteinisation and hyperplasia of the intervening stromal cells. This is a unique case of virilisation caused by transitional cell carcinoma of the ovary. Theories as to the origin of testosterone production in non-functioning ovarian tumours are discussed.
authors.affiliation: Southampton General Hospital, Southampton University Hospital NHS Trust, Southampton, Hampshire SO16 6YD, UK. ljbaldwin@doctors.org.uk
authors.forename: L J
authors.initials: LJ
authors.lastname: Baldwin
authors.forename: N
authors.initials: N
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Tiltman
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology*; D013739:Testosterone / Q000032:analysis; D014770:Virilism / Q000209:etiology / Q000473:pathology*
chemical_list: D013739:Testosterone