Cyclic guanosine monophosphate role in human carcinoma pathogenesis.
In order to examine the cyclic nucleotides (cGMP) role in carcinoma growth and invasivity. We analyzed two cell lines, LSHT29 and 17GT, and tissues in patients with carcinoma and malignant tissues with (N+) and without (N-) lymph node metastases. Higher cGMP levels in pathological samples suggest a strong correlation between intracellular cGMP concentration and carcinoma progression.
Di Nicola
Maurizio
M
Department of Applied Sciences of Oral and Dental Diseases, G. D'Annunzio University, Chieti, Italy.
Santoleri
Fiorenzo
F
Soscia
Stefano
S
Fioroni
Massimiliano
M
Rubini
Corrado
C
Piattelli
Adriano
A
Spoto
Giuseppe
G
D002277:Carcinoma / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D006152:Cyclic GMP / Q000378:metabolism; D018450:Disease Progression; D005887:Gingival Neoplasms / Q000473:pathology*; D006157:Guanosine Monophosphate / Q000502:physiology*; D006801:Humans; D007202:Indicators and Reagents / Q000494:pharmacology; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000473:pathology; D011804:Quinolines / Q000737:chemistry
D007202:Indicators and Reagents; D011804:Quinolines; D006157:Guanosine Monophosphate; C047117:bicinchoninic acid; D006152:Cyclic GMP