Corymbiferan lactones from Penicillium hordei: stimulation of novel phenolic metabolites using plant tissue media.
Cultivation of a strain of Penicillium hordei on macerated tulip tissue agar resulted in the stimulated production of a series of four novel hydroxymethyl naphthalene carboxylic acid lactones from the fungus. The naphthalene derivatives were isolated using a combination of vacuum liquid chromatography and preparative HPLC. Their structures were determined by 1D and 2D NMR techniques in conjunction with high-resolution electrospray mass spectrometry (HRESIMS). These metabolites were given the trivial names corymbiferan lactones A-D (1-4).
Overy
David P
DP
Center for Microbial Biotechnology, Biocentrum-DTU, Building 221, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. do@biocentrum.dtu.dk
Blunt
John W
JW
D002851:Chromatography, High Pressure Liquid; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D010636:Phenols / Q000378:metabolism
D007783:Lactones; D010636:Phenols