[Evaluation of lipoperoxidation in hemodialysis patients with a simple test using the "Free Oxygen Radical Monitor"].
Incidence of cardiovascular events is higher in hemodialysis (HD) patients than in general population. Oxidative stress represents a major specific risk factor of accelerated atheroma particularly in association with inflammation and malnutrition. The aim of our study is to evaluate a simple test of lipid peroxidation measurement using the "Free Oxygen Radical Monitor" (FORM) (Callegari, Italy). The results obtained in HD patients were compared to standard oxidative stress markers, such as thiobarbituric acid reacting substances, carbonyls and vitamin E in plasma, and glutathione, oxidized to reduced form ratio, in erythrocytes. In conclusion, the FORM system presents no sufficient sensibility and specificity to determine oxidative stress in HD patients.
Dortet
L
L
Laboratoire de biochimie A, Hôpital Necker-Enfants Malades, Paris.
Nguyen-Khoa
T
T
Kebede
M
M
Coulloc'h
J
J
Massy
Z
Z
Lacour
B
B
D005260:Female; D005609:Free Radicals / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010100:Oxygen / Q000097:blood*; D006435:Renal Dialysis; D013997:Time Factors
D005609:Free Radicals; D010100:Oxygen