title: A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice.
abstract: The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods termed Odsm1(A). Here we show that phenotypic sex depends on a complex interaction between the suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo.
authors.affiliation: Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Christophe
authors.initials: C
authors.lastname: Poirier
authors.forename: Yangjun
authors.initials: Y
authors.lastname: Qin
authors.forename: Carolyn P
authors.initials: CP
authors.lastname: Adams
authors.forename: Yanett
authors.initials: Y
authors.lastname: Anaya
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Singer
authors.forename: Annie E
authors.initials: AE
authors.lastname: Hill
authors.forename: Eric S
authors.initials: ES
authors.lastname: Lander
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Nadeau
authors.forename: Colin E
authors.initials: CE
authors.lastname: Bishop
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D018392:Genomic Imprinting; D007178:Inbreeding; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010375:Pedigree; D019849:Sex Determination Processes