Evaluation of transdermal morphine and fentanyl pluronic lecithin organogel administration in dogs.
Transdermal administration of morphine and fentanyl using a pluronic lecithin organogel was evaluated in dogs. IV administration of morphine and fentanyl resulted in therapeutic serum drug concentrations. Following transdermal administration, however, median serum drug concentrations were never above the limit of quantitation for morphine or fentanyl. These findings indicate that use ofa pluronic lecithin organogel for transdermal administration of morphine or fentanyl cannot be justified.
Krotscheck
Ursula
U
Department of Clinical Sciences, Cornell University, Ithaca, NY 14853, USA.
Boothe
Dawn M
DM
Boothe
Harry W
HW
D000279:Administration, Cutaneous; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D004285:Dogs; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D005782:Gels; D007275:Injections, Intravenous / Q000662:veterinary; D008081:Liposomes; D008297:Male; D009020:Morphine / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D011897:Random Allocation; D016896:Treatment Outcome
D000701:Analgesics, Opioid; D005782:Gels; D008081:Liposomes; D009020:Morphine; D005283:Fentanyl