title: Successful liver transplantation in a patient with severe haemophilia A and a high-titre factor VIII inhibitor.
abstract: We present the case of a 61-year-old man with severe haemophilia A and a high-titre factor VIII inhibitor who underwent successful orthotopic liver transplantation (OLT) for hepatocellular carcinoma. Postoperatively, a modest early anamnestic response to FVIII was followed by immunological tolerance to FVIII. This case illustrates the technical feasibility of OLT in some patients with high-titre inhibitors to FVIII, and suggests that immune tolerance may be induced by endogenously produced FVIII from the transplanted organ.
authors.affiliation: Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Ashrani
authors.forename: M T
authors.initials: MT
authors.lastname: Reding
authors.forename: A
authors.initials: A
authors.lastname: Shet
authors.forename: J
authors.initials: J
authors.lastname: Osip
authors.forename: A
authors.initials: A
authors.lastname: Humar
authors.forename: J R
authors.initials: JR
authors.lastname: Lake
authors.forename: N S
authors.initials: NS
authors.lastname: Key
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D005240:Feasibility Studies; D006467:Hemophilia A / Q000628:therapy*; D019698:Hepatitis C, Chronic / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged
chemical_list: D005169:Factor VIII