title: [Distribution of E-selectin gene polymorphism in the Zhuangs and Hans of Guangxi province in China].
abstract: OBJECTIVE
  To unveil the distribution of E-selectin G98T polymorphism in exon 2 and the S128R polymorphism in exon 4 of the Chinese Zhuang and Han ethnic groups in Guangxi province.
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), gene sequencing and DNA sequencing were performed on 162 healthy Zhuangs and 170 healthy Hans.
  
  
  RESULTS
  The allele frequencies of G, T for E-selectin polymorphism in the exon 2 were 94.8% and 5.2% in Zhuangs, 95.3% and 4.7% in Hans, respectively; The allele frequencies of S, R for E-selectin polymorphism in the exon 4 were 92.0% and 8.0% in Zhuangs, 95.9% and 4.1% in Hans, respectively. There was significant difference in frequencies of genotype and allele in E-selectin S128R polymorphism between Zhuangs and Hans(chi-square test=4.482, P=0.034).
  
  
  CONCLUSIONS
  There was significant difference in the E-selectin S128R polymorphism between Zhuangs and Hans. There was no significant difference in the E-selectin G98T polymorphism between Zhuangs and Hans.
authors.affiliation: Department of Laboratory Science, Affiliated Hospital of Youjiang Medical College, Baise, Guangxi, 533000 P. R. China.
authors.forename: Ye-sheng
authors.initials: YS
authors.lastname: Wei
authors.forename: Yan
authors.initials: Y
authors.lastname: Lan
authors.forename: Shi-ku
authors.initials: SK
authors.lastname: Du
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D019040:E-Selectin / Q000235:genetics*; D005091:Exons; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D019040:E-Selectin