Inhibition of sarcoplasmic Ca2+ adenosine triphosphatase in porcine skeletal muscle samples with cyclopiazonic acid enables in vitro malignant hyperthermia discrimination.
Gerbershagen
Mark Ulrich
MU
Department of Anesthesiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany. gerbershagen@uke.uni-hamburg.de
Wappler
Frank
F
Fiege
Marko
M
Weihorn
Ralf
R
Kolodzie
Kerstin
K
Schulte Esch
Jochen
J
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis*; D009119:Muscle Contraction / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology*; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*; D013552:Swine
D004791:Enzyme Inhibitors; D007211:Indoles; D019837:Ryanodine Receptor Calcium Release Channel; D000252:Calcium-Transporting ATPases; C000543:cyclopiazonic acid