[Changes in the emotional processing in depressive patients: a study with functional magnetoresonance tomography under the employment of pictures with affective contents].
OBJECTIVE
The influence of emotional contents on brain activation was examined using functional magnetic resonance tomography (fMRT).


METHODS
Aquiring 100 EPI-measurements of the whole brain, series of positive and negative pictures from the International Affective Picture System (IAPS) were shown to eight depressed males and to healthy controls.


RESULTS
In depression, there was an overactivation in hippocampal area during positive stimulation, whereas an overactivation of amygdala, orbital and prefrontal regions was seen during negative stimulation.


CONCLUSIONS
These results emphasize the importance of functional interaction between the neural network associated with emotion. We could show that depression is connected to dysregulation and disturbed functional connectivity during emotional processing.
Wagner
Verena
V
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg am Bezirksklinikum Regensburg. wagnerova@web.de
Müller
Jürgen L
JL
Sommer
Monika
M
Klein
Helmfried E
HE
Hajak
Göran
G
D000328:Adult; D000339:Affect / Q000502:physiology*; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D004193:Discrimination Learning / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology; D010364:Pattern Recognition, Visual / Q000502:physiology; D012016:Reference Values