[Effect of tongbiling on the expression of MCP-1 mRNA of synovial cells in rats with adjuvant arthritis].
OBJECTIVE
To study the effect of tongbiling, a complex preparation of Chinese traditional medicine, on the expression of MCP-1 mRNA of synovial cells in rats with adjuvant arthritis.


METHODS
The expression level of MCP-1 mRNA in synoviocytes from rats with adjuvant arthritis was assayed by the method of RT-PCR.


RESULTS
The amounts of MCP-1 mRNA expression in synoviocytes from rats with adjuvant arthritis were distinctly decreased by tongbiling. It suggested that tongbiling had inhibition effect on rheumatoid arthritis by a down regulation for the expression of MCP-1 mRNA in the inflamed synoviocytes.
Xiong
Maolin
M
Sun Yat-sen Medical College, Sun Yat-sen University, Guangzhou 510080.
Song
Chang
C
Lin
Jingming
J
Song
Liechang
L
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000378:metabolism / Q000473:pathology*; D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000473:pathology*; D002478:Cells, Cultured; D018932:Chemokine CCL2 / Q000096:biosynthesis* / Q000235:genetics; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005786:Gene Expression Regulation; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013583:Synovial Membrane / Q000166:cytology / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018932:Chemokine CCL2; D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger