Oral cancer risk and molecular markers.
The clinical appearance and, especially, the degree of dysplasia that may be shown by pre-cancerous lesions in the oral cavity suggest a potential for malignisation. An increasing number of studies are seeking new, more specific markers that would help to determine the degree of cell alteration and enable a better understanding of the degree of malignant degeneration of these cells. The present review considers the most recent findings for these markers, grouping them into families: tumour growth markers; markers of tumour suppression and anti-tumour response; angiogenesis markers; markers of tumour invasion and metastatic potential; cell surface markers; intracellular markers; markers derived from arachidonic acid; and enzymatic markers.
Chimenos-Küstner
Eduardo
E
Facultad de Odontología, Universidad de Barcelona. 13598eck@comb.es
Font-Costa
Imma
I
López-López
José
J
D014408:Biomarkers, Tumor / Q000032:analysis* / Q000096:biosynthesis; D006801:Humans; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D012307:Risk Factors
D014408:Biomarkers, Tumor