Versatile synthesis of Boc protected hydrazinoacetic acid and its application to the chemoselective ligation of TASP molecules.
This paper describes a convenient synthesis of protected hydrazine derivatives, i.e. 1,2-bis-Boc-hydrazinoacetic acid, and its application for hydrazone ligation techniques in convergent template assembled synthetic protein (TASP) synthesis.
Banfi
Damiano
D
Institute of Chemical Sciences and Engineering, Federal Institute of Technology Lausanne, CH-1015 Lausanne, Switzerland.
Mutter
Manfred
M
Patiny
Luc
L
D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000378:metabolism; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000378:metabolism
D010446:Peptide Fragments; C063864:hydrazinoacetic acid; D005998:Glycine