[Extracorporeal membrane oxygenation treatment with high-volume hemofiltration in patients with multiple organ dysfunction syndrome].
OBJECTIVE
To evaluate whether extracorporeal membrane oxygenation (ECMO) with high-volume hemofiltration (HVHF) improves hypoxemia and renal function in patients with multiple organ dysfunction syndrome (MODS).


METHODS
The study was executed in 8 MODS patients with acute respiratory distress syndrome (ARDS) and acute renal failure (ARF). They were randomly assigned to either 8 hours of HVHF combined with ECMO or HVHF alone in random order. The changes in arterial oxygen pressure(PO(2)), pulse oxygen saturation (SpO(2)), arterial carbon dioxide pressure (PCO(2)), serum creatinine (SCr) and blood urea nitrogen (BUN) levels were measured.


RESULTS
Compared with that of before the treatment, PO(2) was increased significantly at 1, 4, 8 hours, and SpO(2) was increased significantly at 4, 8 hours after ECMO with HVHF in MODS patients, the changes of PO(2), SpO(2)and PCO(2)were not significantly during HVHF (all P>0.05). The average concentrations of BUN and SCr were decreased significantly after HVHF or HVHF with ECMO therapy in MODS patients.


CONCLUSIONS
HVHF with ECMO, which can improve hypoxemia significantly, may be a better option for the treatment of MODS patients.
Tao
Li-jian
LJ
Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
Zhang
Jun
J
Ai
Hang-yu
HY
Zhao
Shuang-ping
SP
Cai
Hong-wen
HW
Ning
Jian-ping
JP
Xu
Hui
H
D000328:Adult; D001806:Blood Urea Nitrogen; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006440:Hemofiltration; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000628:therapy*; D010100:Oxygen / Q000097:blood
D010100:Oxygen