title: Psychosocial factors and the response to influenza vaccination in older adults.
abstract: OBJECTIVE
  We examined the influence of psychological state (depression, negative affect, perceived stress) and social support on pre- and post-vaccination response to influenza vaccine.
  
  
  METHODS
  Venous blood was drawn from 37 nursing home residents before and following injection of the trivalent influenza vaccine (comprised of the New Caledonia (NC), Hong Kong (HK), and Panama (Pan) strains of flu). The Geriatric Depression Scale, Perceived Stress Scale, Positive and Negative Affect Schedule, and Multidimensional Scale of Perceived Social Support were completed following the initial blood draw.
  
  
  RESULTS
  Social support and perceived stress were correlated with pre-vaccine antibody responses to two of the three vaccine components (HK and NC). Social support was negatively correlated with both pre- and post-vaccine titers to Pan. Depression, positive affect, and negative affect were not related to vaccine response.
  
  
  CONCLUSIONS
  Perceived stress and social support influence the rate of decline of antibody titers to previous exposures to some strains of influenza occurring either naturally or via deliberate vaccination.
authors.affiliation: Department of Psychiatry, University of Rochester Medical Center, Box PSYCH, 300 Crittenden Blvd., Rochester, NY 14642, USA. jan_moynihan@urmc.rochester.edu
authors.forename: Jan A
authors.initials: JA
authors.lastname: Moynihan
authors.forename: Mark R
authors.initials: MR
authors.lastname: Larson
authors.forename: John
authors.initials: J
authors.lastname: Treanor
authors.forename: Paul R
authors.initials: PR
authors.lastname: Duberstein
authors.forename: Alan
authors.initials: A
authors.lastname: Power
authors.forename: Bernard
authors.initials: B
authors.lastname: Shore
authors.forename: Robert
authors.initials: R
authors.lastname: Ader
mesh_terms: D000339:Affect; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology*; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology* / Q000627:therapeutic use; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D032541:Mass Vaccination / Q000379:methods; D009735:Nursing Homes; D009975:Orthomyxoviridae / Q000276:immunology; D011569:Psychiatric Status Rating Scales; D012944:Social Support; D013315:Stress, Psychological / Q000175:diagnosis* / Q000523:psychology; D014611:Vaccination / Q000379:methods
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines