[Significance of a new PTH assay (the comparison between whole-PTH and intact-PTH assay)].
It has been shown that intact-PTH assay measures not only full-length biologically active PTH with 84 amino acids, but also some PTH fragments such as (7-84) PTH. Whole-PTH assay is a new method believed to react only with (1-84) PTH. Because circulatory concentrations of various fragments of PTH are very high especially in patients with secondary hyperparathyroidism associated with renal failure, evaluation of PTH levels by whole-PTH assay seems to be useful for accurate assessment of parathyroid function in these patients.
Ito
Nobuaki
N
Division of Nephrology and Endocrinology, Department of Internal Medicine, University of Tokyo.
Fukumoto
Seiji
S
D015415:Biomarkers / Q000097:blood; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000175:diagnosis* / Q000209:etiology; D015592:Immunoradiometric Assay / Q000379:methods; D010281:Parathyroid Hormone / Q000097:blood*; D051437:Renal Insufficiency / Q000150:complications
D015415:Biomarkers; D010281:Parathyroid Hormone