title: A new cytotoxic naphthoquinone from Paepalanthus latipes.
abstract: Quinones constitute an important class of naturally occurring compounds. They are found in plants, fungi and bacteria. Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the isolation, structure determination and the cytotoxic index of a new 1,4-naphthoquinone isolated from the capitula of Paepalanthus latipes.
authors.affiliation: Instituto de Química de Araraquara, Universidade Estadual Paulista Júlio de Mesquita Filho, Rua Prof. Francisco Degni, Araraquara, SP, Brazil.
authors.forename: Rodrigo Rezende
authors.initials: RR
authors.lastname: Kitagawa
authors.forename: Maria Stella Gonçalves
authors.initials: MS
authors.lastname: Raddi
authors.forename: Lourdes Campaner Dos
authors.initials: LC
authors.lastname: Santos
authors.forename: Wagner
authors.initials: W
authors.lastname: Vilegas
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D039262:Eriocaulaceae / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D017382:Reactive Oxygen Species; D021241:Spectrometry, Mass, Electrospray Ionization; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009285:Naphthoquinones; D017382:Reactive Oxygen Species; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue