Progressive prosopagnosia: clinical and neuroimaging results.
The authors report the longitudinal case study of a patient with the right temporal variant of frontotemporal lobar degeneration. His deficit, initially limited to visuoperceptual disturbances, progressed 2 years later to a severe semantic breakdown. Neuroimaging data indicate that the underlying degenerative process, initially confined to unimodal visual associative cortices, progressed along the ventral pathways to multimodal areas in charge of integrating knowledge from various modalities (the anterior temporal lobes).
Joubert
S
S
Service de Neurologie et de Neuropsychologie, AP-HM Timone, Marseille, France. sven.joubert@medecine.univ-mrs.fr
Felician
O
O
Barbeau
E
E
Sontheimer
A
A
Guedj
E
E
Ceccaldi
M
M
Poncet
M
M
D000368:Aged; D001284:Atrophy; D002540:Cerebral Cortex / Q000473:pathology*; D018450:Disease Progression; D005190:Family; D005197:Famous Persons; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000523:psychology; D009483:Neuropsychological Tests; D020238:Prosopagnosia / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology* / Q000523:psychology; D013702:Temporal Lobe / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon