title: Update on human alpha1-adrenoceptor subtype signaling and genomic organization.
abstract: Alpha1-adrenoceptors are G-protein-coupled receptors that bind catecholamines. Sixteen distinct human alpha1A-adrenoceptor isoforms have been identified from human tissues, including five full-length and 11 truncated versions. An updated scheme for the identification of alpha1A-adrenoceptor splice variants is proposed. Given the established roles of alpha1-adrenoceptors in benign prostatic hyperplasia, myocardial hypertrophy and other cardiovascular disorders, elucidation of the biological significance of the signaling diversity and potential pharmacological roles of alpha1A-adrenoceptor splice variants are important areas of future research.
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: K Ashley
authors.initials: KA
authors.lastname: Hawrylyshyn
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Michelotti
authors.forename: Francis
authors.initials: F
authors.lastname: Cogé
authors.forename: Sophie-Pénélope
authors.initials: SP
authors.lastname: Guénin
authors.forename: Debra A
authors.initials: DA
authors.lastname: Schwinn
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D006801:Humans; D020033:Protein Isoforms / Q000145:classification / Q000235:genetics / Q000502:physiology; D018340:Receptors, Adrenergic, alpha-1 / Q000145:classification / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction; D009626:Terminology as Topic
chemical_list: D020033:Protein Isoforms; D018340:Receptors, Adrenergic, alpha-1