[Olfactory function and olfactory marker protein in patients with chronic sinusitis].
OBJECTIVE
To study the pathogenesis of dysosphresia in patients with chronic sinusitis, to discuss the expression and significance of olfaction marker protein in olfactory mucosa.


METHODS
There were 55 cases with chronic sinusitis in the experimental group, and 11 cases in the control. All of them were first tested by subjective method, and then the olfactory marker protein in olfactory mucosa was examined by the method of immunohistochemistry. Tissue sections were observed under optical microscope.


RESULTS
The ratio of dysosphresia in patients with chronic sinusitis was 50.9% (28/55), while by subjective olfactory test, it was 85.5% (47/55). The ratio of dysosphresia in control patients was 9.09% (1/11), by subjective olfactory test, it was 18.2% (2/11). Olfactory marker protein was identified in the olfactory cells and microvillar cells by histochemical and immunohistochemical technique (S-P method).


CONCLUSIONS
The main cause of dysosphresia in patients with chronic sinusitis is the decrease, atrophy and degeneration of the olfactory cells, which lead to the failure of olfactus perception and recognition.
Gao
Hai-yan
HY
Department of Otorhinolaryngology, First Hospital of Inner Mongolia Medical Academy, Huhhot 010050, China. hygao@yahoo.com
Zhu
Xiao-nong
XN
Peng
Shi-dong
SD
Zhang
Hu-he
HH
Fan
Er-zhong
EZ
Wang
Hong
H
Han
De-min
DM
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D051842:Olfactory Marker Protein / Q000378:metabolism*; D009831:Olfactory Mucosa / Q000503:physiopathology*; D012852:Sinusitis / Q000150:complications / Q000378:metabolism*; D055815:Young Adult
D051842:Olfactory Marker Protein