title: Synthesis and urease enzyme inhibitory effects of some dicoumarols.
abstract: Dicoumarols 1-10 with substituted phenyl residues at C-11 were synthesized and screened for their urease inhibition effects. All synthesized compounds showed varying degree of urease inhibitory activity ranging from IC50 = 74.30-91.35 microM.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan. hassaan2@super.net.pk
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Khan
authors.forename: Sajid
authors.initials: S
authors.lastname: Iqbal
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Lodhi
authors.forename: Ghulam M
authors.initials: GM
authors.lastname: Maharvi
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: M I
authors.initials: MI
authors.lastname: Choudhary
authors.lastname: Atta-Ur-Rahman
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D001728:Dicumarol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007887:Fabaceae / Q000201:enzymology; D015394:Molecular Structure; D014510:Urease / Q000037:antagonists & inhibitors* / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D001728:Dicumarol; D014510:Urease