Cerebrospinal fluid markers that predict SIV CNS disease.
Predictive cerebrospinal fluid markers would provide valuable tools for tracking the development and progression of HIV CNS disease. In this study, expression of IL-6, MCP-1, and viral RNA in cerebrospinal fluid collected from SIV-inoculated macaques during acute, asymptomatic, and terminal stages of infection was quantitated to determine whether one or several of these parameters paralleled the severity of SIV encephalitis. Animals that developed moderate to severe SIV encephalitis had significantly elevated levels of CSF IL-6, MCP-1, and SIV RNA during asymptomatic infection and persisting through terminal disease as compared to animals developing mild or no CNS disease.
Mankowski
J L
JL
Department of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jmankows@jhmi.edu
Queen
S E
SE
Clements
J E
JE
Zink
M C
MC
D000818:Animals; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000209:etiology / Q000821:virology; D018932:Chemokine CCL2 / Q000134:cerebrospinal fluid* / Q000235:genetics; D004195:Disease Models, Animal; D015850:Interleukin-6 / Q000134:cerebrospinal fluid* / Q000235:genetics; D008254:Macaca nemestrina; D012313:RNA / Q000134:cerebrospinal fluid / Q000378:metabolism; D016097:Simian Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid / Q000150:complications* / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000378:metabolism; D013997:Time Factors
D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D015850:Interleukin-6; D012313:RNA