title: Benzoic acid derivatives from Piper species and their fungitoxic activity against Cladosporium cladosporioides and C. sphaerospermum.
abstract: Piper crassinervium, P. aduncum, P. hostmannianum, and P. gaudichaudianum contain the new benzoic acid derivatives crassinervic acid (1), aduncumene (8), hostmaniane (18), and gaudichaudianic acid (20), respectively, as major secondary metabolites. Additionally, 19 known compounds such as benzoic acids, chromenes, and flavonoids were isolated and identified. The antifungal activity of these compounds was evaluated by bioautographic TLC assay against Cladosporium cladosporioides and C. sphaerospermum.
authors.affiliation: Instituto de Química, Universidade de São Paulo, C.P. 26077-05599-970, São Paulo, SP, Brazil.
authors.forename: João Henrique G
authors.initials: JH
authors.lastname: Lago
authors.forename: Clécio Sousa
authors.initials: CS
authors.lastname: Ramos
authors.forename: Diego Campos C
authors.initials: DC
authors.lastname: Casanova
authors.forename: Andreia de A
authors.initials: Ade A
authors.lastname: Morandim
authors.forename: Debora Cristina B
authors.initials: DC
authors.lastname: Bergamo
authors.forename: Alberto J
authors.initials: AJ
authors.lastname: Cavalheiro
authors.forename: Vanderlan da S
authors.initials: Vda S
authors.lastname: Bolzani
authors.forename: Maysa
authors.initials: M
authors.lastname: Furlan
authors.forename: Elsie F
authors.initials: EF
authors.lastname: Guimarães
authors.forename: Maria Claudia M
authors.initials: MC
authors.lastname: Young
authors.forename: Massuo J
authors.initials: MJ
authors.lastname: Kato
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D002855:Chromatography, Thin Layer; D002963:Cladosporium / Q000187:drug effects*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031701:Piper / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D001565:Benzoates; C494627:aduncumene; C494626:crassinervic acid; C494629:gaudichaudianic acid; C494628:hostmaniane