title: [The trend of childhood bacterial meningitis in Japan (2000-2002)].
abstract: We surveyed the epidemiology of bacterial meningitis in pediatrics between July 2000 and December 2002 in Japan and obtained the following results.: The number of cases of bacterial meningitis was 316 (182 boys and 134 girls), which was equivalent to 1.1-1.7 children out of 1,000 hospitalized those in pediatrics per year. The age-distribution for the infections was the highest under 1 year of age and it decreased as the age increased. Haemophilus influenzae was the most common pathogen causing the infections, followed by Streptococcus pneumoniae, group B streptococcus, and Escherichia coli. Relationship between causing pathogens and age-distribution was as follows: group B streptococcus and E. coli were major pathogens under 4 months of age and H. influenzae and S. pneumoniae were major pathogens over 4 months of age. Susceptibility tests performed at each facility demonstrated that 53.7% of H. influenzae isolates and 67.7% of S. pneumoniae isolates in 2003 were drug-resistant. As ampicillin and cephem antibiotics are effective against GBS, E. coli and Listeria at present, then the combination of ampicillin and cephem antibiotics was used as first line antibiotics in many facilities under 4 month of age and a combination of carbapenem which showed effective against PRSP and cephem which showed effective against H. influenzae is first choice against childhood bacterial meningitis over 4 month of age.
authors.affiliation: Department of Infectious Diseases, Kitasato University School of Medicine.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sunakawa
authors.forename: Masato
authors.initials: M
authors.lastname: Nonoyama
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ooishi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwata
authors.forename: Hironobu
authors.initials: H
authors.lastname: Akita
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Sato
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ubukata
authors.forename: Nahoko
authors.initials: N
authors.lastname: Chiba
authors.forename: Keiko
authors.initials: K
authors.lastname: Hasegawa
mesh_terms: D017677:Age Distribution; D000667:Ampicillin / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D020814:Meningitis, Escherichia coli / Q000453:epidemiology; D008583:Meningitis, Haemophilus / Q000453:epidemiology; D008586:Meningitis, Pneumococcal / Q000453:epidemiology; D005464:Fluorobenzenes; D005466:Fluorocarbons
chemical_list: D000667:Ampicillin; D002511:Cephalosporins; C483605:7-(1-pentafluorophenoxyacetamido)-3-(2-(5-methyl-1,3,4-thiodiazolyl)thiomethyl)-delta(3)-cephem-4-carboxylic acid; D005464:Fluorobenzenes; D005466:Fluorocarbons