Late-onset optic pathway tumors in children with neurofibromatosis 1.
Identification of new optic pathway tumors (OPTs) and progression of pre-existing OPTs in children with neurofibromatosis 1 (NF1) have been reported infrequently after age 6. The authors present eight children with NF1 (mean age 12.2 years) seen in three NF1 centers who had either late-onset (four of eight) or late-progressive (seven of eight) OPT. Continued monitoring of individuals with NF1 into adulthood for the development of OPTs and for progression of known OPTs is warranted.
Listernick
R
R
Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. boblist@northwestern.edu
Ferner
R E
RE
Piersall
L
L
Sharif
S
S
Gutmann
D H
DH
Charrow
J
J
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001254:Astrocytoma / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy; D019090:Case Management; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D018450:Disease Progression; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000453:epidemiology / Q000235:genetics; D009456:Neurofibromatosis 1 / Q000175:diagnosis / Q000453:epidemiology*; D020339:Optic Nerve Glioma / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy; D019574:Optic Nerve Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy; D012189:Retrospective Studies