title: Preparation of poly(epsilon-caprolactone)/continuous bioglass fibre composite using monomer transfer moulding for bone implant.
abstract: Poly(epsilon-caprolactone) (PCL)/continuous bioglass fibre composite was prepared using the monomer transfer moulding technique coupled with a surface initiated polymerisation. The bioglass fibres were surface treated with an amine ended silane in order to initiate polymerisation of epsilon-caprolactone from the fibre surface. Surface initiated polymerisation significantly improved the Young's modulus and flexural strength and water resistance of the composite. Initial in vitro biocompatibility assessment suggests that amine ended silane treatment of bioglass fibres before their inclusion in the composite does not have a negative effect on the biological responses in terms of macrophage activation as measured by IL-1beta release and craniofacial osteoblast attachment.
authors.affiliation: School of Mechanical, Materials, Manufacturing Engineering and Management, The University of Nottingham, University Park, Nottingham NG7 2RD, UK.
authors.forename: G
authors.initials: G
authors.lastname: Jiang
authors.forename: M E
authors.initials: ME
authors.lastname: Evans
authors.forename: I A
authors.initials: IA
authors.lastname: Jones
authors.forename: C D
authors.initials: CD
authors.lastname: Rudd
authors.forename: C A
authors.initials: CA
authors.lastname: Scotchford
authors.forename: G S
authors.initials: GS
authors.lastname: Walker
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D018786:Bone Substitutes / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology; D049109:Cell Proliferation; D002470:Cell Survival; D002478:Cells, Cultured; D002516:Ceramics / Q000737:chemistry*; D004548:Elasticity; D005898:Glass; D006801:Humans; D008264:Macrophages / Q000166:cytology* / Q000502:physiology*; D008422:Materials Testing; D051379:Mice; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D011091:Polyesters; C425330:bioactive glass 45S5; C016240:polycaprolactone