Listeria monocytogenes sigmaB contributes to invasion of human intestinal epithelial cells.
The role of sigma(B) in Listeria monocytogenes infection of human intestinal epithelial cells was investigated. Invasion defects associated with loss of sigma(B) paralleled those of a DeltainlA strain independently of the sigma(B)-dependent P2(prfA) promoter. Concomitantly, amounts of inlA transcript and InlA protein were significantly decreased in the DeltasigB strain.
Kim
Heesun
H
Department of Microbiology and Immunology, VMC 5-169, Cornell University, Ithaca, NY 14853, USA.
Boor
Kathryn J
KJ
Marquis
Hélène
H
D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology*; D008089:Listeria monocytogenes / Q000472:pathogenicity*; D012333:RNA, Messenger / Q000032:analysis; D012808:Sigma Factor / Q000502:physiology*
D001426:Bacterial Proteins; D012333:RNA, Messenger; C079011:SigB protein, Bacteria; D012808:Sigma Factor; C069761:internalin protein, Bacteria