title: Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
abstract: A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.
authors.affiliation: Merck Research Laboratories, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Blizzard
authors.forename: Frank
authors.initials: F
authors.lastname: Dininno
authors.forename: Jerry D
authors.initials: JD
authors.lastname: Morgan
authors.forename: Helen Y
authors.initials: HY
authors.lastname: Chen
authors.forename: Jane Y
authors.initials: JY
authors.lastname: Wu
authors.forename: Seongkon
authors.initials: S
authors.lastname: Kim
authors.forename: Wanda
authors.initials: W
authors.lastname: Chan
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Birzin
authors.forename: Yi Tien
authors.initials: YT
authors.lastname: Yang
authors.forename: Lee-Yuh
authors.initials: LY
authors.lastname: Pai
authors.forename: Paula M D
authors.initials: PM
authors.lastname: Fitzgerald
authors.forename: Nandini
authors.initials: N
authors.lastname: Sharma
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Zhoupeng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Edward C
authors.initials: EC
authors.lastname: Hayes
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Dasilva
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Susan P
authors.initials: SP
authors.lastname: Rohrer
authors.forename: James M
authors.initials: JM
authors.lastname: Schaeffer
authors.forename: Milton L
authors.initials: ML
authors.lastname: Hammond
mesh_terms: D008024:Ligands; D008958:Models, Molecular; D010075:Oxathiins / Q000737:chemistry / Q000494:pharmacology*; D011759:Pyrrolidines / Q000737:chemistry*; D011960:Receptors, Estrogen / Q000187:drug effects* / Q000378:metabolism; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology*
chemical_list: D008024:Ligands; D010075:Oxathiins; D011759:Pyrrolidines; D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators; C500019:dihydrobenzoxathiin; C032519:pyrrolidine