[Some pathophysiological mechanisms of muscular tone impairment].
Pathophysiological mechanisms of the muscular tone was studied clinicoelectrophysiologically (the method of stimulating electromyography with evoked H-reflex) in 130 healthy subjects and 63 patients with dystonia musculorum deformans (23 patients of the latter were examined before and after intake of a therapeutic dose of L-DOPA). It was found that patients with impaired muscular tone have low activity of spinal motoneurons on both sides of the body especially the activity of phasic motoneurons and on the right side of the body. L-DOPA activates motoneurons, higher activation seen for the phasic motoneurons and on the right side of the body.
Bogdanova
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D000293:Adolescent; D000328:Adult; D001921:Brain / Q000187:drug effects / Q000502:physiology; D004422:Dystonia Musculorum Deformans / Q000188:drug therapy / Q000503:physiopathology*; D004558:Electric Stimulation; D004576:Electromyography; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D009129:Muscle Tonus / Q000187:drug effects / Q000502:physiology*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000503:physiopathology*
D007980:Levodopa