Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic.
The role of immunity in blinding trachoma is unclear. Conjunctival gene expression was measured in a population where trachoma is endemic. Proinflammatory (tumor necrosis factor alpha and interleukin-1beta [IL-1beta]), anti-inflammatory (IL-10), and fibrogenic (matrix metalloprotease 9) gene expression was increased in active trachoma. Markers indicative of T-cell response (gamma interferon, IL-4, IL-12p40, and perforin) were increased when chlamydial infection was present.
Burton
Matthew J
MJ
International Centre for Eye Health, London School of Hygiene and Tropical Medicine, Keppel St., London WC1E 7HT, United Kingdom. matthew.burton@lshtm.ac.uk
Bailey
Robin L
RL
Jeffries
David
D
Mabey
David C W
DC
Holland
Martin J
MJ
D002648:Child; D024042:Collagen Type I / Q000235:genetics; D003228:Conjunctiva / Q000378:metabolism*; D016207:Cytokines / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014141:Trachoma / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000235:genetics; D053781:Transforming Growth Factor beta2
D024042:Collagen Type I; D016207:Cytokines; D012333:RNA, Messenger; C509041:TGFB2 protein, human; D016212:Transforming Growth Factor beta; D053781:Transforming Growth Factor beta2; D020780:Matrix Metalloproteinase 9; D020781:Matrix Metalloproteinase 1