title: [Antiaggregant and antioxidant activity of estradiol and tamoxifen].
abstract: Tamoxifen did not influence the human platelet aggregation in vitro, while estradiol at a concentration of 10(-6) M inhibited the aggregation of human thrombocytes induced by ADP, serotonin + adrenaline, and adrenaline (epinephrine) by 14.7, 12.5, and 16.6%, respectively. Estradiol introduced in the range of effective concentrations from 10(-8) to 10(-4) M inhibited lipid peroxidation, while tamoxifen produced this effect only at a concentration of 10(-4) M. There was a correlation between the antiaggregant activity and antioxidant properties of estradiol.
authors.forename: A I
authors.initials: AI
authors.lastname: Matiushin
authors.forename: N L
authors.initials: NL
authors.lastname: Shimanovskiĭ
authors.forename: A B
authors.initials: AB
authors.lastname: Chekalov
mesh_terms: D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D013629:Tamoxifen / Q000494:pharmacology*
chemical_list: D004965:Estrogen Antagonists; D013629:Tamoxifen; D004958:Estradiol