Black pigmentation of bone due to long-term minocycline use.
Minocycline-induced dark pigmentation has been described affecting the oral cavity (teeth, mucosa, alveolar bone), skin, nails, eyes and thyroid. To date, there is no report of other bones being affected. We report a case of black pigmentation of the acromian in a patient who had used minocycline on a long-term basis for acne rosecea. Biopsy of the iliac crest revealed that the pelvis was also affected.
Pandit
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Perth Royal Infirmary, Perth PH1 1NX, UK. drswapnilp@yahoo.com
Hadden
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D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001847:Bone Diseases / Q000139:chemically induced*; D003937:Diagnosis, Differential; D006801:Humans; D006811:Humerus; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use; D010859:Pigmentation Disorders / Q000139:chemically induced*; D012393:Rosacea / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D008911:Minocycline