Circulating tenascin-C levels in patients with idiopathic dilated cardiomyopathy.
Circulating serum tenascin-C (an extracellular matrix glycoprotein) levels in patients with idiopathic dilated cardiomyopathy (IDC) were measured. Serum tenascin-C levels were increased in proportion to the severity of left ventricular dysfunction in patients with IDC. The associations of serum tenascin-C levels with serum troponin T and procollagen type III aminoterminal peptide levels suggest that increased levels of serum tenascin-C indicate ongoing replacement fibrosis after myocardial damage in IDC.
Aso
Nobuko
N
Second Department of Internal Medicine, Oita University, Oita, Japan.
Tamura
Akira
A
Nasu
Masaru
M
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D002311:Cardiomyopathy, Dilated / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D019063:Tenascin / Q000097:blood*; D018487:Ventricular Dysfunction, Left
D015415:Biomarkers; D019063:Tenascin