title: Lipid peroxidation and antioxidants status in patients with papillary thyroid carcinoma in India.
abstract: The levels of lipid peroxidation products (TBARS), non-enzymatic antioxidants and enzymatic antioxidants activity were investigated in plasma and erythrocytes of twenty clinically diagnosed stage II papillary thyroid cancer patients and an equal number of age and sex matched healthy subjects. An increase in the levels of lipid peroxidation products, decrease in non-enzymatic antioxidants levels and enzymatic antioxidant activities in plasma and erythrocytes were detected in papillary thyroid cancer patients as compared to healthy subjects. Impairment in antioxidant defence mechanisms are responsible for enhanced lipid peroxidation observed in plasma and erythrocytes of papillary thyroid cancer patients.
authors.affiliation: Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar-608 002, Tamilnadu, India.
authors.forename: Namasivayam
authors.initials: N
authors.lastname: Senthil
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Manoharan
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000097:blood* / Q000201:enzymology / Q000473:pathology; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007194:India / Q000453:epidemiology; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009752:Nutritional Status; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000097:blood* / Q000201:enzymology / Q000473:pathology; D014810:Vitamin E / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D001205:Ascorbic Acid