Uncoupling protein-2/uncoupling protein-3 gene polymorphism is not associated with anorexia nervosa.
Energy expenditure abnormalities have been observed in anorexia nervosa (AN). The uncoupling proteins (UCPs) have been implicated as having a role in energy metabolism and thermogenesis, and an association between a marker flanking the UCP-2/UCP-3 gene cluster and AN has been reported. Also known are insertion/deletion and -866G/A polymorphisms in the UCP-2 gene, and the -55C/T polymorphism in the UCP-3 gene. Differences in these alleles are reportedly related to changes in energy expenditure, body mass index, fat tissue accumulation and obesity. Therefore, this case-control association analysis was done to determine whether any of these UCP-2/3 gene polymorphisms are related to a predisposition to AN. In analysis of a cohort of 106 female Japanese AN sufferers and 126 normal female controls, we found no between-group differences in the polymorphism frequencies of these groups. The hypothesis that differences in the UCP-2/3 gene influence the susceptibility to AN was not supported.
Ando
Tetsuya
T
Division of Psychosomatic Research, National Institute of Mental Health, Kohnodai Hospital, National Center of Neurology and Psychiatry, Ichikawa, Chiba, Japan. ando@ncnp-k.go.jp
Kodama
Naoki
N
Ishikawa
Toshio
T
Naruo
Tetsuro
T
Tachikawa
Naoko
N
Nozaki
Takehiro
T
Okabe
Kenjiro
K
Takeuchi
Kaori
K
Masuda
Akinori
A
Kawamura
Noriyuki
N
Komaki
Gen
G
D000328:Adult; D000856:Anorexia Nervosa / Q000235:genetics*; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D017931:DNA Primers; D005260:Female; D006801:Humans; D007297:Inpatients; D007473:Ion Channels; D026901:Membrane Transport Proteins / Q000235:genetics*; D024101:Mitochondrial Proteins / Q000235:genetics*; D005810:Multigene Family; D010045:Outpatients; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D017384:Sequence Deletion; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3
D002352:Carrier Proteins; D017931:DNA Primers; D007473:Ion Channels; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; C000604389:UCP2 protein, human; C000604392:UCP3 protein, human; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3