Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.
Blizzard
Timothy A
TA
Merck Research Laboratories, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com
Dininno
Frank
F
Morgan
Jerry D
JD
Chen
Helen Y
HY
Wu
Jane Y
JY
Kim
Seongkon
S
Chan
Wanda
W
Birzin
Elizabeth T
ET
Yang
Yi Tien
YT
Pai
Lee-Yuh
LY
Fitzgerald
Paula M D
PM
Sharma
Nandini
N
Li
Ying
Y
Zhang
Zhoupeng
Z
Hayes
Edward C
EC
Dasilva
Carolyn A
CA
Tang
Wei
W
Rohrer
Susan P
SP
Schaeffer
James M
JM
Hammond
Milton L
ML
D008024:Ligands; D008958:Models, Molecular; D010075:Oxathiins / Q000737:chemistry / Q000494:pharmacology*; D011759:Pyrrolidines / Q000737:chemistry*; D011960:Receptors, Estrogen / Q000187:drug effects* / Q000378:metabolism; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology*
D008024:Ligands; D010075:Oxathiins; D011759:Pyrrolidines; D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators; C500019:dihydrobenzoxathiin; C032519:pyrrolidine