N-phosphoryl amino acids and biomolecular origins.
The possible role of phosphoryl amino acids for biomolecular origins is briefly reviewed. Peptide formation, ester formation, ester exchange on phosphorus and N to O migration occurred when the N-phosphoryl amino acid was incubated at room temperature. Short nucleotides and peptides were formed when nucleoside was reacted with N-phosphoryl amino acid at room temperature. Serine and threonine residues in their conjugate with different nucleosides (mediated with phosphorus) showed different self-cleavage activities. N-phosphoryl Histine and Ser-His dipeptide could cleave nucleic acids, proteins and esters in neutral medium. Based on a simple model, a pathway of 'co-evolution of protein and nucleic acid' was proposed.
Cheng
C M
CM
The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, PR China.
Liu
X H
XH
Li
Y M
YM
Ma
Y
Y
Tan
B
B
Wan
R
R
Zhao
Y F
YF
D000596:Amino Acids / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D010758:Phosphorus
D000596:Amino Acids; D004952:Esters; D009705:Nucleosides; D009711:Nucleotides; D010455:Peptides; D010758:Phosphorus