title: [Metabolic adaptation to hypoxia: chronic obstructive pulmonary disease and high altitude].
abstract: The effect of oxygen in modulating metabolism has been largely investigated in vitro and in animal studies, but very little in humans. Body weight loss and muscle fatigability is a common finding in chronic obstructive pulmonary diseases, often difficult to reverse despite an optimal nutritional intake. The aim of this paper is to review recent literature regarding pathological and physiological situations characterized by hypoxia exposure, particularly chronic obstructive pulmonary diseases and high altitude staying.
authors.affiliation: Unité de Nutrition, Hôpitaux Universitaires de Genève.
authors.forename: Sofia L
authors.initials: SL
authors.lastname: Guinot-Bourquin
authors.forename: Comasia A
authors.initials: CA
authors.lastname: Raguso
authors.forename: Claude
authors.initials: C
authors.lastname: Pichard
mesh_terms: D000222:Adaptation, Physiological; D000531:Altitude; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D018763:Muscle Fatigue; D009752:Nutritional Status; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D015431:Weight Loss