title: Pemphigus foliaceus with neutrophilic spongiosis evolving to an atypical pemphigus phenotype.
abstract: A 46-year-old Brazilian man, with initial pustular lesions, neutrophilic spongiosis and subcorneal cleavage evolved to an atypical pemphigus phenotype, with suprabasal acantholysis. Interestingly, his autoantibody profile, tested by immunofluorescence, immunoblotting, enzyme-linked immunosorbent assay, and immunoprecipitation revealed exclusive IgG anti-desmoglein 1 antibodies in all phases of the disease.
authors.affiliation: Department of Dermatology, University of São Paulo, São Paulo, Brazil.
authors.forename: Tatiana Villas Boas
authors.initials: TV
authors.lastname: Gabbi
authors.forename: Isabela M
authors.initials: IM
authors.lastname: Bernardelli
authors.forename: Cláudia G
authors.initials: CG
authors.lastname: Santi
authors.forename: Celina W
authors.initials: CW
authors.lastname: Maruta
authors.forename: Vanessa
authors.initials: V
authors.lastname: Kodani
authors.forename: Mirian N
authors.initials: MN
authors.lastname: Sotto
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Julio
authors.initials: J
authors.lastname: Hilario-Vargas
authors.forename: Luis A
authors.initials: LA
authors.lastname: Diaz
authors.forename: Evandro A
authors.initials: EA
authors.lastname: Rivitti
authors.forename: Valéria
authors.initials: V
authors.lastname: Aoki
mesh_terms: D000051:Acantholysis; D001323:Autoantibodies / Q000032:analysis; D015820:Cadherins / Q000276:immunology; D051183:Desmoglein 1; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D004817:Epidermis / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D020556:Neutrophil Infiltration; D010392:Pemphigus / Q000276:immunology*; D010641:Phenotype; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D015820:Cadherins; D051183:Desmoglein 1; D007074:Immunoglobulin G