title: Azithromycin retards Pseudomonas aeruginosa biofilm formation.
abstract: Using a flow cell biofilm model, we showed that a sub-MIC of azithromycin (AZM) can delay but not inhibit Pseudomonas aeruginosa biofilm formation and results in the development of a stable AZM resistance phenotype. Furthermore, mature biofilms were not affected by AZM.
authors.affiliation: Department of Microbiology and Immunology, Box 672, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Gillis
authors.forename: Barbara H
authors.initials: BH
authors.lastname: Iglewski
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D024881:Drug Resistance, Bacterial; D008826:Microbial Sensitivity Tests; D018613:Microscopy, Confocal; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin