Bacterial ghosts--biological particles as delivery systems for antigens, nucleic acids and drugs.
Despite the exponential rate of discovery of new antigens and DNA vaccines resulting from modern molecular biology and proteomics, the lack of effective delivery technology is a major limiting factor in their application. The bacterial ghost system represents a platform technology for antigen, nucleic acid and drug delivery. Bacterial ghosts have significant advantages over other engineered biological delivery particles, owing to their intrinsic cellular and tissue tropic abilities, ease of production and the fact that they can be stored and processed without the need for refrigeration. These particles have found both veterinary and medical applications for the vaccination and treatment of tumors and various infectious diseases.
Tabrizi
Chakameh Azimpour
CA
Institute of Microbiology and Genetics, Section Microbiology and Biotechnology, University of Vienna, Althanstrasse 14, UZAII, 2B 522, A-1090 Vienna, Austria.
Walcher
Petra
P
Mayr
Ulrike Beate
UB
Stiedl
Thomas
T
Binder
Matthias
M
McGrath
John
J
Lubitz
Werner
W
D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D001419:Bacteria; D016503:Drug Delivery Systems; D006801:Humans; D009696:Nucleic Acids / Q000008:administration & dosage*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
D000941:Antigens; D009696:Nucleic Acids; D004364:Pharmaceutical Preparations