Value of Hu antibody determinations in the follow-up of paraneoplastic neurologic syndromes.
The long-term evolution of Hu antibody (Hu-Ab) titers in patients with paraneoplastic neurologic syndromes (PNSs) is not known. Described is the evolution of Hu-Ab titers in 35 patients with PNS with a median follow-up of 32 months (range 6 to 108 months). No correlation was observed between Hu-Ab titers and neurologic outcome, tumor evolution, or type of treatment. Serial Hu-Ab determinations are not useful for monitoring the clinical outcome of patients with PNS.
Lladó
A
A
Service of Neurology, Hospital Clínic, Universitat de Barcelona, and Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona. Spain.
Mannucci
P
P
Carpentier
A F
AF
Paris
S
S
Blanco
Y
Y
Saiz
A
A
Delattre
J Y
JY
Graus
F
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D002276:Carcinoid Tumor / Q000150:complications / Q000276:immunology / Q000628:therapy; D018288:Carcinoma, Small Cell / Q000150:complications / Q000276:immunology / Q000628:therapy; D018450:Disease Progression; D051959:ELAV Proteins; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D020361:Paraneoplastic Syndromes, Nervous System / Q000097:blood / Q000276:immunology*; D011237:Predictive Value of Tests; D016601:RNA-Binding Proteins / Q000276:immunology*; D012189:Retrospective Studies; D016896:Treatment Outcome
D001323:Autoantibodies; D001324:Autoantigens; D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins