title: Primary vaginal adenosarcoma with sarcomatous overgrowth.
abstract: BACKGROUND
  Primary vaginal adenosarcomas are extremely rare, and typical adenosarcomas are of low malignancy. However, aggressive forms with sarcomatous overgrowth have been reported, those appear to have a poor prognosis.
  
  
  METHODS
  A 52-year-old woman who had undergone prior surgery for uterine leiomyoma and an ovarian cyst (total abdominal hysterectomy and left salpingo-oophorectomy) presented 10 years later with a rapidly enlarging tumor arising from the vaginal cuff. Repetitive biopsy samples revealed a mixture of benign epithelial gland and malignant stromal components with periglandular stromal hypercellularity and sarcomatous overgrowth. A histological diagnosis of mullerian adenocarcinoma was made. The patient died from recurrent disease 9 months after surgery.
  
  
  CONCLUSIONS
  Regardless of primary focus, adenosarcoma with sarcomatous overgrowth is associated with postoperative recurrence and a fatal outcome.
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba, Sendai 980-8574, Japan. m-toyo@mail.tains.tohoku.ac.jp
authors.forename: Masafumi
authors.initials: M
authors.lastname: Toyoshima
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Akahira
authors.forename: Takuya
authors.initials: T
authors.lastname: Moriya
authors.forename: Seiichirou
authors.initials: S
authors.lastname: Hayakawa
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
mesh_terms: D018195:Adenosarcoma / Q000188:drug therapy / Q000473:pathology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology*; D010052:Ovariectomy; D014594:Uterine Neoplasms / Q000601:surgery; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000473:pathology*