Molecular design of synthetic receptors with dynamic, imprinting, and allosteric functions.
Sugar recognition in an aqueous system has been achieved using a boronic acid-diol interaction. Combination with an intramolecular amino group has enabled us to read out the binding process as a change in the fluorescence intensity. The novel interaction has been extended to dynamic sugar sensing utilizing an allosteric effect, molecular imprinting, and control of molecular assemblies.
Shinkai
Seiji
S
Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka, Japan. seijitcm@mbox.nc.kyushu-u.ac.jp
Takeuchi
Masayuki
M
D032701:Biomimetics / Q000379:methods*; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D001897:Boronic Acids / Q000737:chemistry*; D015195:Drug Design; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004579:Electron Transport; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D007700:Kinetics; D010777:Photochemistry / Q000295:instrumentation / Q000379:methods*; D011956:Receptors, Cell Surface / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013237:Stereoisomerism; D013499:Surface Properties
D001897:Boronic Acids; D011956:Receptors, Cell Surface; D005947:Glucose