The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice.
Neurotensin (NT), a tridecapeptide found in the mammalian brain and peripheral tissues, induces a decrease in food intake after central administration. In this investigation, we examine whether the histaminergic system is involved in NT-induced suppression of feeding. Intracerebroventricular injection of NT (0.1-1 nmol/mouse) led to dose-dependent inhibition of food intake in fasted ddY mice. The anorectic effect induced by NT (0.1 nmol/mouse) was ameliorated upon co-administration of pyrilamine (3 nmol/mouse), an antagonist for histomine H1 receptor. The NT-induced anorectic effect was partially ameliorated in H1 knockout mice. The findings suggest that the H1 receptor in part mediates the NT-induced suppression of food intake.
Ohinata
Kousaku
K
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto 611-0011, Japan.
Shimano
Tomoko
T
Yamauchi
Rena
R
Sakurada
Shinobu
S
Yanai
Kazuhiko
K
Yoshikawa
Masaaki
M
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009496:Neurotensin / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000502:physiology*
D001067:Appetite Depressants; D011969:Receptors, Histamine H1; D009496:Neurotensin