title: Influence of diabetes on long-term outcome among unselected patients with acute coronary events.
abstract: OBJECTIVE
  The aims of this study were to investigate the prognostic influence of diabetes after an episode of unstable angina pectoris or non-Q-wave myocardial infarction (MI) and to investigate whether diabetes is independently associated with increased short- and long-term mortality risk following these episodes.
  
  
  METHODS
  Consecutive patients with a diagnosis of unstable angina pectoris or non-Q-wave MI, admitted to the Coronary Care Unit at Ostra Hospital, Göteborg, Sweden during 1988-1998 were included. The primary endpoint was 2-year mortality collected from the Swedish cause-specific mortality register.
  
  
  RESULTS
  The study included 4341 patients, 722 (17%) had diabetes. Diabetes was associated with increased mortality during initial hospitalization (10.2% vs 5.7%, p < 0.0001), after 30 days (13% vs 7.5%, p < 0.0001), and at 2 years (33.7% vs 20.2%, p < 0.0001). After adjustment for potentially confounding factors, diabetes remained an independent predictor of 2-year mortality following unstable coronary syndromes, the hazard ratio (HR) of death (HR = 1.6; 95% CI 1.4-1.9).
  
  
  CONCLUSIONS
  Among patients with unstable coronary syndromes, diabetes is an independent risk factor associated with increased mortality during hospitalization, short- and long-term follow-up.
authors.affiliation: Clinical Experimental Research Laboratory, Sahlgrenska University Hospital/Ostra, Göteborg, Sweden. ann-marie.svensson@hjl.gu.se
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Svensson
authors.forename: Putte
authors.initials: P
authors.lastname: Abrahamsson
authors.forename: Darren K
authors.initials: DK
authors.lastname: McGuire
authors.forename: Mikael
authors.initials: M
authors.lastname: Dellborg
mesh_terms: D017677:Age Distribution; D000368:Aged; D000789:Angina, Unstable / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D015331:Cohort Studies; D003131:Combined Modality Therapy; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D018579:Patient Selection; D011336:Probability; D011379:Prognosis; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D016019:Survival Analysis; D013548:Sweden / Q000453:epidemiology; D015912:Thrombolytic Therapy / Q000379:methods; D016896:Treatment Outcome