title: Peptide self-assembly as a model of proteins in the pre-genomic world.
abstract: Excellent catalytic efficiency has been obtained within a series of self replicating peptides, and nucleobase inclusion into a salt-switchable self replicating peptide is found to override the switch. Interestingly, cross-catalytic formation of an RNA aptamer is reported with a cationic peptide, and novel, amide-based biopolymers have been designed to self assemble.
authors.affiliation: Department of Chemistry, University of Arizona, 1306 E. University Blvd, Tuscon, AZ 85721, USA. ghosh@email.arizona.edu
authors.forename: Indraneel
authors.initials: I
authors.lastname: Ghosh
authors.forename: Jean
authors.initials: J
authors.lastname: Chmielewski
mesh_terms: D000595:Amino Acid Sequence; D005075:Biological Evolution; D002384:Catalysis; D008956:Models, Chemical; D008969:Molecular Sequence Data; D000069497:Origin of Life; D010455:Peptides / Q000737:chemistry*; D014176:Protein Biosynthesis
chemical_list: D010455:Peptides