title: Ensemble hybridisation--a new method for exploring sequence dependent fluorescence of dye-nucleic acid conjugates.
abstract: The fluorescence of thiazole orange as artificial base in PNA was investigated in a nearest neighbour analysis; library-to-library hybridisation allowed the identification of probe sequences suitable for homogeneous DNA detection.
authors.affiliation: Institut für Chemie, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, D-12489 Berlin, Germany.
authors.forename: Olaf
authors.initials: O
authors.lastname: Köhler
authors.forename: Dilip Venkatrao
authors.initials: DV
authors.lastname: Jarikote
authors.forename: Oliver
authors.initials: O
authors.lastname: Seitz
mesh_terms: D052160:Benzothiazoles; D005456:Fluorescent Dyes / Q000737:chemistry*; D015723:Gene Library; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D011804:Quinolines; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D052160:Benzothiazoles; D005456:Fluorescent Dyes; D020135:Peptide Nucleic Acids; D011804:Quinolines; D013844:Thiazoles; C051000:thiazole orange