Liver transplantation for acute hepatic failure.
BACKGROUND
The mortality rate of acute hepatic failure (AHF) with conservative treatment is 40% to 90%, depending on the etiology. Hepatitis B infection is the major cause of AHF in Asia. In this study, we examined the role of liver transplantation for adult patients with AHF.


METHODS
Sixteen patients with AHF received liver transplants in the past 6 years. Eight patients received cadaveric donor and another 8 living-related donor grafts. Fifteen patients suffered from hepatitis B-related disease and 1 had drug-induced AHF. Extracorporeal charcoal hemoperfusion was used as a bridge to liver transplantation in the first 2 patients and plasma exchange was used in the following patients.


RESULTS
One patient died 1 month after the operation due to primary nonfunction. The other 15 patients are alive with good graft function at 2 months to 6 years follow-up. The success rate is 94%. Postoperative complications included infection in 10 patients (62.5%), acute rejection in 4 patients (25%), and biliary complication in 2 patients (12.5%). No neurological complications were noted.


CONCLUSIONS
Liver transplantation is the most effective treatment for patients with AHF. Living donors may be considered due to the organ shortage and the critical patient disease.
Wu
Y-M
YM
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Ho
M-C
MC
Hu
R-H
RH
Ko
W-J
WJ
Yang
P-M
PM
Lai
M-Y
MY
Lee
P-H
PH
D002102:Cadaver; D005190:Family; D005705:Gallbladder Diseases / Q000453:epidemiology; D006801:Humans; D007239:Infections / Q000453:epidemiology; D017114:Liver Failure, Acute / Q000601:surgery*; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D019520:Living Donors; D011183:Postoperative Complications / Q000145:classification; D012189:Retrospective Studies; D014019:Tissue Donors; D016896:Treatment Outcome