[Effect of 3-dimensional conformal hypofractionated high-dose radiotherapy combined with chemotherapy for non-small-cell lung cancer: a clinical observation].
OBJECTIVE
To evaluate the clinical therapeutic effect of three-dimensional conformal hypofractionated high-dose radiotherapy combined with chemotherapy for non-small-cell lung cancer (NSCLC).


METHODS
The combined treatment was carried out in 63 cases of NSCLC and the short-term effects, the patients' survival rate and complications were observed.


RESULTS
Local control of tumor growth was achieved in 79.1% of the patients and the survival rates of 1, 3, and 5 years were 65.2%, 23.2%, and 10.4%, respectively. The median actual survival of the patients was 14 months. Late radiation pneumonitis (grade 3 or 4) and oesophagitis occurred in 9.5% and 4.8% of the patients, respectively.


CONCLUSIONS
Three-dimensional conformal hypofractionated high-dose radiotherapy combined with chemotherapy can be an effective and practical approach to treat NSCLC, but local recurrence remains the major factor of treatment failure.
Jiang
Hua-yong
HY
Department of Radiation Oncology, 148 th Hospital of PLA, Zibo 255300, China. huayong-1@hotmail.com
Wu
De-hua
DH
Chen
Long-hua
LH
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome