The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid.
Because monocyte chemotactic protein (MCP)-1 is an important cofactor in HIV neuropathogenesis, we investigated the relationship between MCP-1 genotype and expression in cerebrospinal fluid (CSF). We evaluated a genetic polymorphism in the MCP-1 promoter at position -2578 (alternatively designated -2518) in 98 HIV-infected subjects who had contemporaneously collected plasma and CSF. CSF MCP-1 levels were highest in the G/G genotype group, intermediate in the G/A group, and lowest in the A/A group. MCP-1 levels in plasma only differed by genotype after adjusting for HIV-related factors. Our findings suggest that this MCP-1 promoter polymorphism influences HIV neuropathogenesis by regulating MCP-1 protein expression in the central nervous system (CNS).
Letendre
Scott
S
Department of Medicine, The HIV Neurobehavioral Research Center, 150 West Washington Street, San Diego, CA 92103, USA. sletendre@ucsd.edu
Marquie-Beck
Jennifer
J
Singh
Kumud K
KK
de Almeida
Sergio
S
Zimmerman
Joshua
J
Spector
Stephen A
SA
Grant
Igor
I
Ellis
Ronald
R
D000328:Adult; D000483:Alleles; D018932:Chemokine CCL2 / Q000097:blood / Q000134:cerebrospinal fluid* / Q000235:genetics / Q000378:metabolism*; D003710:Demography; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D012333:RNA, Messenger