title: Monte carlo simulation of the Leksell Gamma Knife: II. Effects of heterogeneous versus homogeneous media for stereotactic radiosurgery.
abstract: The absence of electronic equilibrium in the vicinity of bone-tissue or air-tissue heterogeneity in the head can misrepresent deposited dose with treatment planning algorithms that assume all treatment volume as homogeneous media. In this paper, Monte Carlo simulation (PENELOPE) and measurements with a specially designed heterogeneous phantom were applied to investigate the effect of air-tissue and bone-tissue heterogeneity on dose perturbation with the Leksell Gamma Knife. The dose fall-off near the air-tissue interface caused by secondary electron disequilibrium leads to overestimation of dose by the vendor supplied treatment planning software (GammaPlan) at up to 4 mm from an interface. The dose delivered to the target area away from an air-tissue interface may be underestimated by up to 7% by GammaPlan due to overestimation of attenuation of photon beams passing through air cavities. While the underdosing near the air-tissue interface cannot be eliminated with any plug pattern, the overdosage due to under-attenuation of the photon beams in air cavities can be eliminated by plugging the sources whose beams intersect the air cavity. Little perturbation was observed next to bone-tissue interfaces. Monte Carlo results were confirmed by measurements. This study shows that the employed Monte Carlo treatment planning is more accurate for precise dosimetry of stereotactic radiosurgery with the Leksell Gamma Knife for targets in the vicinity of air-filled cavities.
authors.affiliation: Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202-5289, USA. vmoskvin@iupui.edu
authors.forename: Vadim
authors.initials: V
authors.lastname: Moskvin
authors.forename: Robert
authors.initials: R
authors.lastname: Timmerman
authors.forename: Colleen
authors.initials: C
authors.lastname: DesRosiers
authors.forename: Marcus
authors.initials: M
authors.lastname: Randall
authors.forename: Paul
authors.initials: P
authors.lastname: DesRosiers
authors.forename: Phil
authors.initials: P
authors.lastname: Dittmer
authors.forename: Lech
authors.initials: L
authors.lastname: Papiez
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D001921:Brain / Q000503:physiopathology / Q000528:radiation effects; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D011785:Quality Assurance, Health Care / Q000379:methods*; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods*; D011874:Radiometry / Q000379:methods*; D016634:Radiosurgery / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012886:Skull / Q000503:physiopathology / Q000528:radiation effects