title: [Incidence of rigor during treatment with flupentixol decanoate in comparison to risperidone].
abstract: OBJECTIVE
  We investigated as to whether dosedependent extrapyramidal tolerance of Flupentixol decanoate is inferior to that of Risperidone.
  
  
  METHODS
  143 Risperidone and 177 Flupentixol decanoate treated patients were consecutively entered into this non - randomized open study and assessed with the Simpson-Angus-Scale regarding presence of rigor. Treatment comparisons of rigor frequency was done by Kaplan-Meier analysis.
  
  
  RESULTS
  The risk of rigor increased with dose on both treatments. EPMS-risk was not increased under treatment with Flupentixol decanoate (mean dose 35.06 +/- 19.7 mg/2 weeks) compared to Risperidone (mean daily dose: 5.2 +/- 2.5 mg/kg) when comparable weight standardized Haloperidol equivalence doses (WHE) were used.
  
  
  CONCLUSIONS
  This study offers limited evidence for methodological reasons. Yet, results do not support the view that EPS are more frequent on Flupentixol decanoate than on Risperidone when doses are comparable.
authors.affiliation: Klinik des Bezirks Oberbayern am Klinikum Garmisch-Partenkirchen. josef.scherer@psychiatrie-gap.de
authors.forename: Josef
authors.initials: J
authors.lastname: Scherer
authors.forename: Peter
authors.initials: P
authors.lastname: Dobmeier
authors.forename: Karin
authors.initials: K
authors.lastname: Kuhn
authors.forename: Werner
authors.initials: W
authors.lastname: Schmaus
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D001835:Body Weight; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D005475:Flupenthixol / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D009460:Neurologic Examination / Q000187:drug effects; D011446:Prospective Studies; D018967:Risperidone / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; C007761:flupenthixol decanoate; D005475:Flupenthixol; D006220:Haloperidol; D018967:Risperidone