[Neuroprotective effects of magnesium on cerebral ischemia and cerebral contusion].
Neuroprotective effects of magnesium (Mg(2+)) have been shown in experimental studies by using animal models of the cerebral ischemia and cerebral contusion. We review the neuroprotective effects of Mg(2+) in the histological and behavioral studies. In the animal models of cerebral ischemia, Mg(2+) treatment reduces the infarct volume, inhibits the neuronal death, and attenuates the motor impairments. In the animal models of cerebral contusion, Mg(2+) treatment inhibits the neuronal death and edema, and attenuates not only the motor impairments but also cognitive dysfunction.
Enomoto
Takeshi
T
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine.
Noda
Yukihiro
Y
Nabeshima
Toshitaka
T
D000818:Animals; D001921:Brain / Q000473:pathology; D001930:Brain Injuries / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D002413:Cations, Divalent; D016923:Cell Death; D003071:Cognition; D004195:Disease Models, Animal; D006801:Humans; D007858:Learning; D008274:Magnesium / Q000008:administration & dosage / Q000627:therapeutic use*; D008568:Memory; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011597:Psychomotor Performance
D002413:Cations, Divalent; D018696:Neuroprotective Agents; D008274:Magnesium