Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice.
Odor discrimination times and their dependence on stimulus similarity were evaluated to test temporal and spatial models of odor representation in mice. In a go/no-go operant conditioning paradigm, discrimination accuracy and time were determined for simple monomolecular odors and binary mixtures of odors. Mice discriminated simple odors with an accuracy exceeding 95%. Binary mixtures evoking highly overlapping spatiotemporal patterns of activity in the olfactory bulb were discriminated equally well. However, while discriminating simple odors in less than 200 ms, mice required 70-100 ms more time to discriminate highly similar binary mixtures. We conclude that odor discrimination in mice is fast and stimulus dependent. Thus, the underlying neuronal mechanisms act on a fast timescale, requiring only a brief epoch of odor-specific spatiotemporal representations to achieve rapid discrimination of dissimilar odors. The fine discrimination of highly similar stimuli, however, requires temporal integration of activity, suggesting a tradeoff between accuracy and speed.
Abraham
Nixon M
NM
WIN Group of Olfactory Dynamics, Heidelberger Akademie der Wissenschaften and Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg, Germany.
Spors
Hartwig
H
Carleton
Alan
A
Margrie
Troy W
TW
Kuner
Thomas
T
Schaefer
Andreas T
AT
D000818:Animals; D001931:Brain Mapping; D003216:Conditioning, Operant; D004192:Discrimination, Psychological / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009812:Odorants; D009830:Olfactory Bulb / Q000502:physiology*; D011930:Reaction Time; D012903:Smell / Q000502:physiology*; D013268:Stimulation, Chemical