Animal models of ischemic stroke: balancing experimental aims and animal care.
Animal models of ischemic stroke are examples of an induced model that can present challenges from the perspectives of protocol review and animal management. The review presented here will include a brief summary of the current state of knowledge about clinical stroke; a general synopsis of important unanswered research questions that justify use of animal stroke models; an overview of various animal models of ischemic stroke, including strengths and limitations; and a discussion of animal care issues relative to ischemic stroke models. Good communication and interactive education among primary investigators, laboratory animal veterinarians and caretakers, and institutional animal care and use committee members are critical in achieving a balance between research objectives and animal care issues when using animal stroke models.
Graham
Sharon M
SM
Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.
McCullough
Louise D
LD
Murphy
Stephanie J
SJ
D000822:Animal Husbandry; D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D007756:Laboratory Animal Science / Q000379:methods*; D012107:Research Design; D020521:Stroke / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D014730:Veterinary Medicine / Q000379:methods*