title: Genetic polymorphisms in glutathione-S-transferase genes (GSTM1, GSTT1, GSTP1) and survival after chemotherapy for invasive breast carcinoma.
abstract: BACKGROUND
  It has been suggested that genetic polymorphisms in certain glutathione-S-transferase (GST) genes reduce the effectiveness of detoxifying cytotoxins generated by chemotherapeutic agents, potentially resulting in enhanced clinical responses to chemotherapy.
  
  
  METHODS
  The authors evaluated common polymorphisms in the GSTM1, GSTT1, and GSTP1 genes for associations with overall survival in 1034 patients with invasive breast carcinoma who were recruited into the Shanghai Breast Cancer Study between 1996 and 1998, treated with chemotherapy, and followed for a median of 5.3 years.
  
  
  RESULTS
  After adjusting for age, tumor stage, and the use of radiotherapy and tamoxifen, women who were homozygous for the variant GSTP1 105Val allele had a 60% reduction in mortality risk compared with women who were homozygous for the Ile allele (hazard ratio, 0.4; 95% confidence interval, 0.2-0.8). No association was found with respect to any of the GSTM1 or GSTT1 genotypes.
  
  
  CONCLUSIONS
  The results of the current study indicate a potential role for GSTP1 polymorphism in predicting the clinical outcomes of patients with breast carcinoma who are treated with chemotherapy.
authors.affiliation: Vanderbilt Center for Health Services Research, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-8300, USA. gong.yang@vanderbilt.edu
authors.forename: Gong
authors.initials: G
authors.lastname: Yang
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.forename: Zhi-Xian
authors.initials: ZX
authors.lastname: Ruan
authors.forename: Qiu-Yin
authors.initials: QY
authors.lastname: Cai
authors.forename: Fan
authors.initials: F
authors.lastname: Jin
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000217:Acyltransferases / Q000235:genetics*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D002277:Carcinoma / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011110:Polymorphism, Genetic; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000217:Acyltransferases; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C043403:fatty acyl ethyl ester synthase