[Influence of He-Ne laser irradiation and local anesthetics on potassium channels in the snail neurons].
Using clamp method it had been shown that He-Ne laser irradiation of the snail neurons increases the amplitude of voltage-gated slow potassium currents in dose of 0.7 x 10(-4) (fluence 1.5 x 10(2) Wt/m2) and decreases it in dose 0.7 x 10(-3). Bupivacaine and lidocaine suppressed potassium currents. Laser irradiation in dose 0.7 x 10(-3) enhanced the inhibitory effect of bupivacaine (10 mcM) and in dose 0.7 x 10(-4) it decreased the inhibitory effect of bupivacaine. The results of the study suggest mechanisms of the He-Ne laser irradiation effect in combination with pharmacological substances on ion channels of electrically excitable cells.
Ignatov
Iu D
IuD
Vislobokov
A I
AI
Vlasov
T D
TD
Kolpakova
M E
ME
Mel'nikov
K N
KN
Petrishchev
I N
IN
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002045:Bupivacaine / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000528:radiation effects; D006371:Helium; D007834:Lasers; D008012:Lidocaine / Q000494:pharmacology; D008195:Lymnaea / Q000502:physiology; D009356:Neon; D009474:Neurons / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D018408:Patch-Clamp Techniques; D024642:Potassium Channels, Voltage-Gated / Q000037:antagonists & inhibitors* / Q000528:radiation effects*
D000779:Anesthetics, Local; D024642:Potassium Channels, Voltage-Gated; D006371:Helium; D009356:Neon; D008012:Lidocaine; D002045:Bupivacaine