B-cell antigen receptor-induced apoptosis: looking for clues.
Triggering of the B cell antigen receptor (BCR) can initiate divergent responses ranging from activation and cell division to apoptosis, depending on the differentiation stage and additional signals the cell receives. Despite considerable progress in unraveling general apoptosis pathways, the route from the BCR to apoptosis execution is still quite obscure, and there is no consensus yet concerning the mechanism or the players involved. Here, we will summarize current developments in this field and will attempt to pinpoint key questions and perspectives for future research.
Eldering
Eric
E
Department of Experimental Immunology, Academical Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. e.eldering@amc.uva.nl
VanLier
René A W
RA
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins; D020169:Caspases / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D011947:Receptors, Antigen, B-Cell / Q000502:physiology*; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D051017:Apoptosis Regulatory Proteins; D008562:Membrane Glycoproteins; D011947:Receptors, Antigen, B-Cell; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha; D020169:Caspases