[Effect of glutamine on the non-steroidal anti-inflammatory drug-induced bacterial translocation].
OBJECTIVE
NSAIDs induce gut damage throughout the entire gastrointestinal tract and bacterial translocation. The aim of this study was to examine if administration of glutamine was able to prevent the NSAID-induced gut damages and bacterial translocation in the animal models.


METHODS
Rats were utilized into 5 groups; control group, diclofenac group, and diclofenac with glutamine 0.8, 1.6, and 3.2 g/kg/day group. The animals with glutamine were fed with L-glutamine for 4 days before diclofenac administration. Gut injury was induced by administration of a single dose of diclofenac (80 mg/kg orally). Intestinal permeability (24 hour urinary excretion of phenolsulfonphthalein), enteric aerobic bacterial counts, serum biochemical profiles and bacterial translocation to mesenteric lymph nodes, liver and spleen were measured.


RESULTS
Diclofenac caused the increase in intestinal permeability, enteric bacterial count, enteric protein and albumin loss and bacterial translocation. Administration of glutamine reduced the increase in intestinal permeability, protein losing enteropathy, enteric bacterial overgrowth and bacterial translocation induced by diclofenac.


CONCLUSIONS
Glutamine may have beneficial effects on NSAID-induced gut damage and bacterial translocation.
Ann
Ji Yong
JY
Department of Internal Medicine, Chungang University College of Medicine, Seoul, Korea.
Kim
Sang Jung
SJ
Han
Sang Pyo
SP
Kim
Jeong Wook
JW
Kim
Hyung Joon
HJ
Do
Jae Hyuk
JH
Kim
Jae Gyu
JG
Chang
Sae Kyung
SK
Jeon
Woo Kyu
WK
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D018988:Bacterial Translocation / Q000187:drug effects*; D004008:Diclofenac / Q000494:pharmacology* / Q000633:toxicity; D005973:Glutamine / Q000494:pharmacology*; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*; D008297:Male; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005973:Glutamine; D004008:Diclofenac