[Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth].
OBJECTIVE
To study the chemical constituents of Evodia rutaecarpa (Juss.) Benth.


METHODS
The crude total alkaloids were enriched by acid-base treatment and solvent extraction. Isolation and purification were carried out by silica gel column chromatography and recrystallization etc. Structural determination of the pure compounds were based on physico-chemical properties and various spectral data analysis (1HNMR, 13CNMR, UV, IR, 1H-1H COSY, HMQC, HMBC, ESIMS, HREIMS, NOESY).


RESULTS
Fourteen compounds were obtained from Evodia rutaecarpa, ten of them were identified as evodianinine (1), rutaecarpine (2), evodiamine (3), wuchuyuamide I (4), hydroxyevodiamine (5), limonin (6), daucosterol (7), triacontanoic acid (8), nonacosane (9) and beta-sitosterol (10).


CONCLUSIONS
Compound 1 is a new alkaloid named evodianinine.
Wang
Qi-zhi
QZ
Department of Natural Products Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Liang
Jing-yu
JY
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification*; D032086:Evodia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D026121:Indole Alkaloids; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry*; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification*; D052999:Quinazolinones
D000470:Alkaloids; D002243:Carbolines; D026121:Indole Alkaloids; D010936:Plant Extracts; D011799:Quinazolines; C496396:evodianinine; C028632:rutecarpine; D052999:Quinazolinones; C049639:evodiamine