title: Lymphadenopathy after BCG vaccination in a child with chronic granulomatous disease.
abstract: We report a 15-month-old boy who developed an ulcer in the left axillary fold following bacillus Calmette-Guerin vaccination. Subsequent immunologic and genetic studies led to the diagnosis of chronic granulomatous disease. His mother had "lupus-like" lesions, described in some carriers of this disease, that were thus related to her son's diagnosis. Although in healthy subjects this vaccination is usually harmless, in instances of impaired immunity it may cause adverse reactions. When a vaccine-related complication occurs, an underlying immunodeficiency should be sought.
authors.affiliation: Department of Dermatology, S. Marcos Hospital, Apartado 2242, 4701-965 Braga, Portugal. dermato@hsmbraga.min-saude.pt
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Vieira
authors.forename: Júlia
authors.initials: J
authors.lastname: Vasconcelos
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Fernandes
authors.forename: Henedina
authors.initials: H
authors.lastname: Antunes
authors.forename: A Sousa
authors.initials: AS
authors.lastname: Basto
authors.forename: Cristiana
authors.initials: C
authors.lastname: Macedo
authors.forename: Afsana
authors.initials: A
authors.lastname: Zaman
authors.forename: Eugénia
authors.initials: E
authors.lastname: Santos
authors.forename: J Castro
authors.initials: JC
authors.lastname: Melo
authors.forename: Dirk
authors.initials: D
authors.lastname: Roos
mesh_terms: D001500:BCG Vaccine / Q000009:adverse effects / Q000276:immunology*; D006098:Granulocytes / Q000276:immunology / Q000378:metabolism; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D007223:Infant; D008206:Lymphatic Diseases / Q000209:etiology*; D008297:Male; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D011379:Prognosis; D012883:Skin Ulcer / Q000209:etiology
chemical_list: D001500:BCG Vaccine