title: Photoacoustic determination of blood vessel diameter.
abstract: A double-ring sensor was applied in photoacoustic tomographic imaging of artificial blood vessels as well as blood vessels in a rabbit ear. The peak-to-peak time (tau(pp)) of the laser (1064 nm) induced pressure transient was used to estimate the axial vessel diameter. Comparison with the actual vessel diameter showed that the diameter could be approximated by 2ctau(pp), with c the speed of sound in blood. Using this relation, the lateral diameter could also precisely be determined. In vivo imaging and monitoring of changes in vessel diameters was feasible. Finally, acoustic time traces were recorded while flushing a vessel in the rabbit ear with saline, which proved that the main contribution to the laser-induced pressure transient is caused by blood inside the vessel and that the vessel wall gives only a minor contribution.
authors.affiliation: Biophysical Engineering, Faculty of Science and Technology, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands. r.g.m.kolkman@utwente.nl
authors.forename: Roy G M
authors.initials: RG
authors.lastname: Kolkman
authors.forename: John H G M
authors.initials: JH
authors.lastname: Klaessens
authors.forename: Erwin
authors.initials: E
authors.lastname: Hondebrink
authors.forename: Jeroen C W
authors.initials: JC
authors.lastname: Hopman
authors.forename: Frits F M
authors.initials: FF
authors.lastname: de Mul
authors.forename: Wiendelt
authors.initials: W
authors.lastname: Steenbergen
authors.forename: Johan M
authors.initials: JM
authors.lastname: Thijssen
authors.forename: Ton G
authors.initials: TG
authors.lastname: van Leeuwen
mesh_terms: D000162:Acoustics; D000465:Algorithms; D000818:Animals; D001808:Blood Vessels / Q000033:anatomy & histology*; D004423:Ear / Q000033:anatomy & histology / Q000098:blood supply; D005240:Feasibility Studies; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007834:Lasers; D019047:Phantoms, Imaging; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014054:Tomography / Q000295:instrumentation / Q000379:methods*; D014732:Vibration