Adipose tissue concentrations of p,p'-DDE and the risk for endometrial cancer.
OBJECTIVE
To evaluate in a case-control study possible risk of endometrial cancer associated with environmental endocrine disruptors.


METHODS
We analyzed the adipose tissue concentrations of polychlorinated biphenyls, hexachlorobenzene (HCB), p,p'-dichlorodiphenyl-dichloroethylene (p,p'-DDE), chlordanes, and polybrominated biphenyls in 76 cases with endometrial cancer and 39 controls with benign endometrial hyperplasia.


RESULTS
For the different chemicals, odds ratios (ORs) and 95% confidence intervals (CI) were close to unity taking the median concentration among the controls as cutoff value. However, for p,p'-DDE OR = 1.9, 95% CI = 0.8-4.8 was obtained. Additional estrogen replacement therapy yielded in this category OR = 2.3, 95% CI = 0.6-8.6.


CONCLUSIONS
The results suggest an interaction between p,p'-DDE and estrogen replacement drugs in the etiology of endometrial cancer, although no significant associations were found.
Hardell
Lennart
L
Department of Oncology, University Hospital, SE-701 85 Orebro, Sweden. lennart.hardell@orebol.se
van Bavel
Bert
B
Lindström
Gunilla
G
Björnfoth
Helén
H
Orgum
Petter
P
Carlberg
Michael
M
Sörensen
Claus Smed
CS
Graflund
Marianne
M
D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002706:Chlordan / Q000493:pharmacokinetics / Q000506:poisoning; D003633:Dichlorodiphenyl Dichloroethylene / Q000493:pharmacokinetics* / Q000506:poisoning; D004347:Drug Interactions; D004714:Endometrial Hyperplasia / Q000139:chemically induced / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000139:chemically induced* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D004967:Estrogens / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006581:Hexachlorobenzene / Q000493:pharmacokinetics / Q000506:poisoning; D020249:Hormone Replacement Therapy; D006801:Humans; D007306:Insecticides / Q000493:pharmacokinetics* / Q000506:poisoning; D008875:Middle Aged; D009367:Neoplasm Staging; D011075:Polybrominated Biphenyls / Q000493:pharmacokinetics / Q000506:poisoning; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics / Q000506:poisoning; D012307:Risk Factors
D004967:Estrogens; D007306:Insecticides; D011075:Polybrominated Biphenyls; D002706:Chlordan; D003633:Dichlorodiphenyl Dichloroethylene; D006581:Hexachlorobenzene; D011078:Polychlorinated Biphenyls