RNA expression analysis of a congenital intracranial teratoma.
Congenital intracranial tumors are extremely rare and account only for 0.5%-1.5% of brain tumors in children. We report a large intrauterine congenital teratoma in a female fetus at gestation weeks 37, which was diagnosed by detecting the tumor and associated craniomegaly with ultrasonography (US) and magnetic resonance (MR) imaging. The tumor had replaced the cerebral hemispheres and produced prenatal manifestations. Pathologic examination showed an immature teratoma, which was differentiated from all three germ layers. Microarray analysis revealed upregulation of ten genes and downregulation of three genes, as well as upregulation of 41 genes of ribosomal proteins in teratoma cells, compared to normal brain tissue of the patient. The data from the microarray analysis offer not only the potential to help define disease pathogenesis but may also provide clues to identify potential molecular therapeutic targets.
Yokoi
Kentaro
K
Department of Pediatrics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan.
Akiyama
Masaharu
M
Yanagisawa
Takaaki
T
Yoshino
Masami
M
Nakazaki
Hiromichi
H
Takahashi
Koichi
K
Takahashi-Fujigasaki
Junko
J
Kanetsuna
Yukiko
Y
Yamada
Hisashi
H
Oi
Shizuo
S
Eto
Yoshikatsu
Y
D000328:Adult; D001932:Brain Neoplasms / Q000151:congenital / Q000175:diagnosis* / Q000235:genetics; D003952:Diagnostic Imaging; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D005333:Fetus; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011247:Pregnancy; D012334:RNA, Neoplasm / Q000032:analysis; D013724:Teratoma / Q000151:congenital / Q000175:diagnosis* / Q000235:genetics
D012334:RNA, Neoplasm