title: Earlier recurrence of esophageal varices, following therapy, in patients with primary biliary cirrhosis (PBC) compared with non-PBC patients.
abstract: BACKGROUND
  Variceal bleeding is a common, life-threatening complication of primary biliary cirrhosis (PBC). Recently, several reports have suggested that the existence of esophageal varices in patients with PBC is a significant factor in the assessment of disease prognosis. However, there have been no reports on the recurrence of esophageal varices following treatment in patients with PBC. In this study, we investigated the recurrence of esophageal varices in PBC patients and attempted to identify predictive factors for the recurrence of esophageal varices.
  
  
  METHODS
  Between April 1993 and August 2003, 138 patients with esophageal varices who had been treated by endoscopic variceal ligation (EVL; 96 men and 42 women; age, 33-83 years; mean, 62.6 +/- 10.1 years), were enrolled in the present study. The diagnosis of esophageal varices was made by upper gastrointestinal endoscopy, and the varices were graded according to the criteria of the Japanese Research Society for Portal Hypertension. The relationship between the recurrence of esophageal varices and factors such as biochemical and hematological parameters, as well as the etiology of the liver disease, was analyzed using the Kaplan-Meier method and the multivariate Weibull regression model.
  
  
  RESULTS
  PBC patients had an earlier recurrence of esophageal varices compared to non-PBC patients, and two factors, prothrombin time and etiology (PBC/non-PBC), were indicative of significantly earlier recurrence of esophageal varices.
  
  
  CONCLUSIONS
  We should be extra careful in the follow-up of patients with PBC after therapy for esophageal varices.
authors.affiliation: Third Department of Internal Medicine, Ehime University School of Medicine, 791-0295, Ehime, Shigenobu-Cho, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Takeshita
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Matsui
authors.forename: Naozumi
authors.initials: N
authors.lastname: Shibata
authors.forename: Shinya
authors.initials: S
authors.lastname: Furukawa
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yokota
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Murakami
authors.forename: Yoshiou
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Bunzo
authors.initials: B
authors.lastname: Matsuura
authors.forename: Kojiro
authors.initials: K
authors.lastname: Michitaka
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji
mesh_terms: D016022:Case-Control Studies; D016099:Endoscopy, Gastrointestinal; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D004945:Esophagoscopy; D005260:Female; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000601:surgery; D006801:Humans; D008026:Ligation; D008105:Liver Cirrhosis, Biliary / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D012008:Recurrence; D013997:Time Factors