title: Acellular pertussis vaccines and complement killing of Bordetella pertussis.
abstract: Antibody-dependent complement killing of Bordetella pertussis after immunization with a three-component acellular pertussis vaccine was characterized. Postimmunization activity was unchanged for about half of the adult vaccine recipients. The responses of the other individuals were complex, with evidence of both beneficial and antagonistic responses occurring, sometimes in the same individual.
authors.affiliation: Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267-0524, USA. Alison.Weiss@uc.edu
authors.forename: Alison A
authors.initials: AA
authors.lastname: Weiss
authors.forename: Angela K
authors.initials: AK
authors.lastname: Patton
authors.forename: Scott H
authors.initials: SH
authors.lastname: Millen
authors.forename: Swei-Ju
authors.initials: SJ
authors.lastname: Chang
authors.forename: Joel I
authors.initials: JI
authors.lastname: Ward
authors.forename: David I
authors.initials: DI
authors.lastname: Bernstein
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D001770:Blood Bactericidal Activity; D001886:Bordetella pertussis / Q000276:immunology*; D003165:Complement System Proteins / Q000502:physiology*; D004311:Double-Blind Method; D006801:Humans; D007114:Immunization; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D010567:Pertussis Vaccine / Q000276:immunology*; D011446:Prospective Studies; D022282:Vaccines, Acellular / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D010567:Pertussis Vaccine; D022282:Vaccines, Acellular; D003165:Complement System Proteins