title: PcMtr, an aromatic and neutral aliphatic amino acid permease of Penicillium chrysogenum.
abstract: The gene encoding an aromatic and neutral aliphatic amino acid permease of Penicillium chrysogenum was cloned, functionally expressed and characterized in Saccharomyces cerevisiae M4276. The permease, designated PcMtr, is structurally and functionally homologous to Mtr of Neurospora crassa, and unrelated to the Amino Acid Permease (AAP) family which includes most amino acid permeases in fungi. Database searches of completed fungal genome sequences reveal that Mtr type permeases are not widely distributed among fungi, suggesting a specialized function.
authors.affiliation: Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands.
authors.forename: Hein
authors.initials: H
authors.lastname: Trip
authors.forename: Melchior E
authors.initials: ME
authors.lastname: Evers
authors.forename: Arnold J M
authors.initials: AJ
authors.lastname: Driessen
mesh_terms: D026905:Amino Acid Transport Systems / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D024322:Amino Acids, Aromatic / Q000378:metabolism; D002244:Carbon / Q000378:metabolism; D002250:Carbon Radioisotopes; D003001:Cloning, Molecular; D005800:Genes, Fungal; D005816:Genetic Complementation Test; D007700:Kinetics; D008969:Molecular Sequence Data; D010408:Penicillium chrysogenum / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D010802:Phylogeny; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013379:Substrate Specificity
chemical_list: D026905:Amino Acid Transport Systems; D000596:Amino Acids; D024322:Amino Acids, Aromatic; D002250:Carbon Radioisotopes; D002244:Carbon