Polymerizable ion-pair amphiphile that has a polymerizable group at cationic ammonium chain.
Polymerizable ion-pair amphiphile (PIPA) that has a polymerizable lipoyl group on cationic ammonium chain was prepared to compare the advantage of ion-pair form with the conventional polymerizable ammonium surfactant in the points of stability of vesicle and permeation properties. PIPA introduced in this paper, compared to previously reported one with polymerizable group on anionic chain side, showed similar vesicle stability in addition to high encapsulation efficiency and resistance to disruption by SDS or Triton X-100. Reasons for such high encapsulation and low permeability of the PIPA vesicle are investigated and the possible applications are briefly discussed.
Chung
Myung-Hoon
MH
Department of Chemistry, Center for Smart Biomaterial, The University of Suwon, Suwon 445-743, Korea.
Park
Jung-Hwan
JH
Chun
Byoung Chul
BC
Chung
Yong-Chan
YC
D000838:Anions; D002412:Cations; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008567:Membranes, Artificial; D017830:Octoxynol / Q000737:chemistry; D010539:Permeability; D011108:Polymers / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D013997:Time Factors
D000838:Anions; D002412:Cations; D008055:Lipids; D008567:Membranes, Artificial; D011108:Polymers; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D017830:Octoxynol; D016650:Fluorescein-5-isothiocyanate