title: Beta-lactam susceptibilities and prevalence of ESBL-producing isolates among more than 5000 European Enterobacteriaceae isolates.
abstract: In vitro susceptibility to 15 beta-lactam antibiotics was evaluated using Enterobacteriaceae isolated during the SENTRY Antimicrobial Surveillance Program. Piperacillin/tazobactam was the most active penicillin against Escherichia coli, Proteus mirabilis, Klebsiella oxytoca and Klebsiella pneumoniae (94.9%, 98.3%, 87.4% and 82.9% of isolates susceptible). Of the cephalosporins, cefepime was most effective against Escherichia coli, Proteus mirabilis and Enterobacter cloacae (99.2%, 96.3% and 95.2% of isolates susceptible, respectively) and cefoxitin against Klebsiella oxytoca and Klebsiella pneumoniae (98.6% and 95.6% of isolates susceptible). Carbapenems had excellent activity (> or =99.5% of all isolates). ESBL-production was confirmed with the ESBL-Etest and disk diffusion test in 1.3% of Escherichia coli isolates, 18.4% of Klebsiella pneumoniae, 12.6% of Klebsiella oxytoca and 5.3% of Proteus mirabilis isolates.
authors.affiliation: Department of Internal Medicine, Division of Emergency Medicine and Infectious Diseases, F.02.126, University Medical Center Utrecht, P.O. Box 85000, 3508 GA Utrecht, The Netherlands. s.nijssen@digd.azu.nl
authors.forename: S
authors.initials: S
authors.lastname: Nijssen
authors.forename: A
authors.initials: A
authors.lastname: Florijn
authors.forename: M J M
authors.initials: MJ
authors.lastname: Bonten
authors.forename: F J
authors.initials: FJ
authors.lastname: Schmitz
authors.forename: J
authors.initials: J
authors.lastname: Verhoef
authors.forename: A C
authors.initials: AC
authors.lastname: Fluit
mesh_terms: D001398:Aztreonam / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D005060:Europe; D006801:Humans; D007709:Klebsiella / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D007710:Klebsiella Infections / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D018440:beta-Lactam Resistance; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000096:biosynthesis / Q000378:metabolism*; D047090:beta-Lactams / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D002511:Cephalosporins; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams; D002939:Ciprofloxacin; D001618:beta-Lactamases; D001398:Aztreonam