title: Effect of azithromycin therapy on coronary circulation in patients with coronary artery disease.
abstract: This study examined the effect of azithromycin therapy on the coronary microcirculation using measurement of coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography in 35 patients with coronary artery disease. CFVR increased significantly after azithromycin therapy (3.0 +/- 0.7 vs 3.5 +/- 0.7, p <0.001). The changes in CFVR were negatively correlated with changes in high-sensitivity C-reactive protein levels in patients receiving azithromycin.
authors.affiliation: Department of Internal Medicine and Cardiology, Osaka City University School of Medicine, Osaka, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Hyodo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hozumi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Kohei
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Muro
authors.forename: Kenei
authors.initials: K
authors.lastname: Shimada
authors.forename: Kaname
authors.initials: K
authors.lastname: Akioka
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshiyama
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoshikawa
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D017963:Azithromycin / Q000494:pharmacology* / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000150:complications* / Q000188:drug therapy*; D003331:Coronary Vessels / Q000502:physiology; D004311:Double-Blind Method; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium; D011446:Prospective Studies; D012039:Regional Blood Flow
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin; D002097:C-Reactive Protein