Correlation of entorhinal amyloid with memory in Alzheimer's and vascular but not Lewy body dementia.
OBJECTIVE
To examine the relationship of the anatomic distribution of amyloid deposition to focal and global cognitive dysfunction in different subtypes of dementia.


METHODS
We quantified AB40 and AB42 in the temporal lobe and entorhinal cortex and examined their relationship to cognitive functions in Alzheimer's disease (AD), vascular dementia (VaD) and dementia with Lewy bodies (DLB).


RESULTS
We found a correlation between memory impairment, but not global cognitive impairment, and amyloid load in these areas in AD and VaD but not in DLB. This relationship was stronger for AB42 and in the entorhinal cortex.


CONCLUSIONS
The anatomic location of amyloid deposition is an important factor-specific factor in memory impairment in AD and VaD.
Thomas
Alan
A
Institute for Ageing and Health, Newcastle, UK.
Ballard
Clive
C
Kenny
Rose Anne
RA
O'Brien
John
J
Oakley
Arthur
A
Kalaria
Raj
R
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology; D000682:Amyloid / Q000032:analysis*; D002540:Cerebral Cortex / Q000473:pathology; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000473:pathology; D018728:Entorhinal Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008568:Memory / Q000502:physiology*; D008609:Mental Status Schedule; D008853:Microscopy; D009483:Neuropsychological Tests; D013223:Statistics as Topic; D013702:Temporal Lobe / Q000473:pathology
D000682:Amyloid