title: New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin.
abstract: Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 microM (1), 1.7 microM (2) and 1.7 microM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 microM).
authors.affiliation: Tsukuba Medicinal Plant Research Station, National Institute of Health Sciences, Hachiman-dai, Tsukuba, Japan.
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Kiuchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsuo
authors.forename: Michiho
authors.initials: M
authors.lastname: Ito
authors.forename: Tran Kim
authors.initials: TK
authors.lastname: Qui
authors.forename: Gisho
authors.initials: G
authors.lastname: Honda
mesh_terms: D000818:Animals; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D021241:Spectrometry, Mass, Electrospray Ionization; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D014344:Trypanocidal Agents