title: Synthesis and in vitro cytostatic activity of some new 1,3-(oxytetraethylenoxy)-cyclotriphosphazatriene derivatives.
abstract: A series of cyclophosphazene crown ether derivatives bearing aziridinyl (ethylene imine) units and also 2-naphthyl or anthraquinone groups as co-substituents has been synthesized and their cytostatic activity against the panel of eight cancer cells in vitro has been studied. The substituents used exhibit different activities: alkylation (aziridinyl groups) and intercalation (naphtyl, anthraquinone groups) against DNA. These both interactions are supposed to enhance the efficiency of the cyclophosphazene crown ether derivatives studied as cytotoxic agents.
authors.affiliation: Center of Polymer Chemistry, PAS, 34 M. Curie-Skłodowska Str., 41-800 Zabrze, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Porwolik-Czomperlik
authors.forename: Mariola
authors.initials: M
authors.lastname: Siwy
authors.forename: Danuta
authors.initials: D
authors.lastname: Sek
authors.forename: Bozena
authors.initials: B
authors.lastname: Kaczmarczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Nasulewicz
authors.forename: Iwona
authors.initials: I
authors.lastname: Jaroszewicz
authors.forename: Marzena
authors.initials: M
authors.lastname: Pełczyńska
authors.forename: Adam
authors.initials: A
authors.lastname: Opolski
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009943:Organophosphorus Compounds