Relationship between hemostatic markers and circulating biochemical markers of collagen metabolism in patients with aortic aneurysm.
Our objective was to determine the relationship between plasma levels of hemostatic molecular markers--D-dimer and thrombin-antithrombin III complex (TAT)--and circulating biochemical markers of collagen metabolism--aminoterminal propeptide of type III procollagen (PIIIP) and carboxyterminal propeptide of type I procollagen (PICP)--in patients with aortic aneurysm. The subjects were 43 patients with aortic aneurysm (AA; mean age 71 years) and 26 age-matched controls (mean age 75 years). The mean D-dimer, TAT and PIIIP levels were higher in the patients than in the controls (p < 0.0001, 0.0001 and 0.012, respectively), while the mean PICP level was similar to that in the controls. Increased D-dimer had a significant correlation with PIIIP (r = 0.412, p = 0.006) and PICP (r = 0.342, p = 0.0246), while TAT correlated with PIIIP (r = 0.3194, p = 0.0374), but not with PICP. There was also a significant correlation (r = 0.306, p = 0.0463) between PIIIP and PICP. As shown by the significant positive correlations among D-dimer, TAT and PIIIP, accelerated fibrinolysis and thrombogenesis induce an increase of collagen degradation and procollagen synthesis in atherosclerotic lesions. These findings show that D-dimer and TAT, especially the former, may be useful markers to monitor the progression and predict the prognosis of AA.
Ihara
Akihiro
A
Department of Hematology, National Hospital Organization Kure Medical Center, Kure, Hiroshima, Japan. a-ihara@kure-nh.go.jp
Kawamoto
Toshiharu
T
Matsumoto
Kengo
K
Kawamoto
Jun
J
Katayama
Akira
A
Yoshitatsu
Masao
M
Izutani
Hironori
H
Ihara
Katsuhiko
K
D000368:Aged; D000369:Aged, 80 and over; D000990:Antithrombin III; D001014:Aortic Aneurysm / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003094:Collagen / Q000378:metabolism*; D024061:Collagen Type III / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000097:blood
D015415:Biomarkers; D024061:Collagen Type III; D005338:Fibrin Fibrinogen Degradation Products; C046193:antithrombin III-protease complex; C036309:fibrin fragment D; D000990:Antithrombin III; D003094:Collagen; D010447:Peptide Hydrolases