title: [NO, a major regulator of metabolic and cardiovascular homeostasis].
abstract: Obesity and insulin resistance are reaching epidemic proportions worldwide. Over the past decade, nitric oxide (NO) has emerged as a key player in the regulation of the metabolic and cardiovascular homeostasis. Here we will review recent data obtained in mice with disruption of the genes encoding for each of the three nitric oxide synthase isoforms. These data demonstrate that both defective and augmented NO synthesis have detrimental effects on the regulation of the metabolic and cardiovascular system. These observations provide the rationale for the use of NO-donors and/or inhibitors of NO overproduction in the treatment of insulin resistance.
authors.affiliation: Département de médecine interne et Botnar Center.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Thalmann
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Jayet
authors.forename: Hervé
authors.initials: H
authors.lastname: Duplain
authors.forename: Pierre
authors.initials: P
authors.lastname: Turini
authors.forename: Claudio
authors.initials: C
authors.lastname: Sartori
authors.forename: Peter
authors.initials: P
authors.lastname: Vollenweider
authors.forename: Urs
authors.initials: U
authors.lastname: Scherrer
mesh_terms: D002320:Cardiovascular Physiological Phenomena; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000503:physiopathology; D009569:Nitric Oxide / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000494:pharmacology*; D010641:Phenotype
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase