Oral vaccination with recombinant Yersinia enterocolitica expressing hybrid type III proteins protects gerbils from amebic liver abscess.
Protection against invasive amebiasis was achieved in the gerbil model for amebic liver abscess by oral immunization with live attenuated Yersinia enterocolitica expressing the Entamoeba histolytica galactose-inhibitable lectin that has been fused to the Yersinia outer protein E (YopE). Protection was dependent on the presence of the YopE translocation domain but was independent from the antibody response to the ameba lectin.
Lotter
Hannelore
H
Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany.
Rüssmann
Holger
H
Heesemann
Jürgen
J
Tannich
Egbert
E
D000284:Administration, Oral; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D004748:Entamoeba histolytica / Q000276:immunology*; D005849:Gerbillinae; D006801:Humans; D037102:Lectins / Q000276:immunology*; D008101:Liver Abscess, Amebic / Q000517:prevention & control*; D011993:Recombinant Fusion Proteins / Q000276:immunology*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology*; D015008:Yersinia enterocolitica / Q000235:genetics*
D001425:Bacterial Outer Membrane Proteins; D037102:Lectins; D011993:Recombinant Fusion Proteins; D014614:Vaccines, Synthetic; C063239:yopE protein, Yersinia