title: Peptide nucleic acids with a flexible secondary amine in the backbone maintain oligonucleotide binding affinity.
abstract: [structure: see text] Replacing a secondary amide in a peptide nucleic acid backbone with a more flexible secondary amine affords an oligomer that surprisingly maintains the same binding affinity to complementary oligonucleotides as the unmodified polyamide oligomer.
authors.affiliation: Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Myers
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Pokorski
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Appella
mesh_terms: D000588:Amines / Q000737:chemistry*; D018076:DNA, Complementary / Q000378:metabolism*; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D018075:RNA, Complementary / Q000378:metabolism*; D013696:Temperature
chemical_list: D000588:Amines; D018076:DNA, Complementary; D020135:Peptide Nucleic Acids; D018075:RNA, Complementary