title: Unusual skin reactions after mosquito bites and Epstein-Barr virus reactivation in a patient with mantle cell lymphoma.
abstract: We detected Epstein-Barr virus (EBV) reactivation in a patient with mantle cell lymphoma (MCL). The patient, a 53-year-old Japanese man, had been referred to our hospital because of generalized lymphadenopathy, hepatosplenomegaly and lymphocytosis and gave a history of intense skin reactions to mosquito bites. The biopsied lymph node contained a monotonous proliferation of medium-sized lymphocytes with scant cytoplasm and slightly irregular nuclei that were CD5+, CD20+ and CD23-. Antibody titers of IgG against EBV viral capsid antigen and early antigen were increased, and EBV was detected in the lymphoma cells. This case may suggest a relationship between EBV and MCL.
authors.affiliation: Department of Internal Medicine, Tokushima Prefectural Central Hospital, 1-10-3 Kuramoto-cho, Tokushima 770-0042.
authors.forename: Toshio
authors.initials: T
authors.lastname: Shigekiyo
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ohmori
authors.forename: Masahito
authors.initials: M
authors.lastname: Chohraku
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Ohtsuka
authors.forename: Kazue
authors.initials: K
authors.lastname: Yamabe
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takishita
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Takai
authors.forename: Masanori
authors.initials: M
authors.lastname: Takahashi
authors.forename: Shingo
authors.initials: S
authors.lastname: Wakatsuki
mesh_terms: D000818:Animals; D009033:Culicidae / Q000276:immunology; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007299:Insect Bites and Stings / Q000276:immunology; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000209:etiology; D008218:Lymphocytosis / Q000209:etiology; D020522:Lymphoma, Mantle-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology