title: 5'-Homoaristeromycin. Synthesis and antiviral activity against orthopox viruses.
abstract: An efficient synthesis of 5'-homoaristeromycin has been developed. This permitted an extensive antiviral analysis, which found potent activity toward vaccinia, cowpox, and monkeypox viruses. For comparative purposes, 5'-homoadenosine was made available by a newly designed route and found to be inactive.
authors.affiliation: Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA.
authors.forename: Minmin
authors.initials: M
authors.lastname: Yang
authors.forename: Stewart W
authors.initials: SW
authors.lastname: Schneller
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D018155:Orthopoxvirus / Q000187:drug effects*
chemical_list: C500020:5'-homoaristeromycin; D000998:Antiviral Agents; D000241:Adenosine