title: Adaptive optics simulation of intraocular lenses with modified spherical aberration.
abstract: OBJECTIVE
  Adaptive optics systems can be used to investigate the potential visual benefit associated with correcting ocular wave-front aberration. In this study, adaptive optics techniques were used to evaluate the potential advantages and disadvantages associated with intraocular lenses (IOLs) with modified spherical aberration profiles.
  
  
  METHODS
  An adaptive optics vision simulator was constructed that allows psychophysical tests to be performed while viewing targets through any desired ocular wave-front profile. With this simulator, the subjective visual performance of four subjects was assessed by letter acuity and contrast sensitivity (at 3, 6, and 15 cyc/deg) for two different values of induced spherical aberration. The values of spherical aberration were chosen to reproduce two conditions: the average amount measured in pseudophakic patients with implanted IOLs having spherical surfaces and the complete correction of the individual's spherical aberration. Visual performance was assessed in both white and green light, at best focus and for defocus of +/-0.5 and +/-1.0 D.
  
  
  RESULTS
  There was an average improvement in visual acuity associated with the correction of spherical aberration of 10% and 38% measured in white and green light, respectively. Similarly, average contrast sensitivity measurements improved 32% and 57% in white and green light. When spherical aberration was corrected, visual performance was as good as or better than for the normal spherical aberration case for defocus as large as +/-1 D.
  
  
  CONCLUSIONS
  Correcting ocular spherical aberration improves spatial vision in the best-focus position without compromising the subjective tolerance to defocus.
authors.affiliation: AMO Groningen, Groningen, P.O. Box 901, 9700 AX Groningen, The Netherlands. patricia.piers@amo-inc.com
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Piers
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: Fernandez
authors.forename: Silvestre
authors.initials: S
authors.lastname: Manzanera
authors.forename: Sverker
authors.initials: S
authors.lastname: Norrby
authors.forename: Pablo
authors.initials: P
authors.lastname: Artal
mesh_terms: D000328:Adult; D003198:Computer Simulation; D015350:Contrast Sensitivity; D019781:Corneal Topography; D004867:Equipment Design; D006801:Humans; D007910:Lenses, Intraocular; D008962:Models, Theoretical; D055095:Optics and Photonics / Q000295:instrumentation; D019591:Pseudophakia / Q000503:physiopathology; D014792:Visual Acuity