title: Sex and ceruloplasmin modulate the response to copper exposure in healthy individuals.
abstract: Previous studies indicated that sex might influence the response to copper exposure. Ceruloplasmin (Cp) is an indicator of Cu status, but it is not clear whether and how it reflects changes of Cu status among healthy individuals. In this study, 82 apparently healthy women and men were chosen from 800 individuals because their Cp values belonged to the higher and lower 10% of the group Cp distribution curve. Before and after receiving a supplement of 10mg Cu/day (upper limit of daily intake) for 2 months, we performed blood and urinary biochemical measurement of potential Cu markers. We used principal component analysis and linear discriminant analysis to identify blood and/or urinary Cu indicators that showed a differential response to copper. Results showed that Cp values in serum represent a reliable indicator to differentiate subgroups within the normal population in their response to Cu exposure. The response depends on Cp values and on sex, such that women with higher and men with lower Cp values exhibit the greatest response.
authors.affiliation: Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile. mmendez@inta.cl
authors.forename: Marco A
authors.initials: MA
authors.lastname: Méndez
authors.forename: Magdalena
authors.initials: M
authors.lastname: Araya
authors.forename: Manuel
authors.initials: M
authors.lastname: Olivares
authors.forename: Fernando
authors.initials: F
authors.lastname: Pizarro
authors.forename: Mauricio
authors.initials: M
authors.lastname: González
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002570:Ceruloplasmin / Q000494:pharmacology*; D003300:Copper / Q000008:administration & dosage / Q000097:blood* / Q000652:urine*; D004032:Diet; D004785:Environmental Pollutants / Q000097:blood* / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D025341:Principal Component Analysis; D011446:Prospective Studies; D012737:Sex Factors
chemical_list: D004785:Environmental Pollutants; D003300:Copper; D002570:Ceruloplasmin