A new cytoskeletal connection for APC: linked to actin through IQGAP.
Migrating cells reorganize their actin and microtubule cytoskeletons in response to external cues. In this issue of Developmental Cell, Watanabe et al. now show a molecular connection between the actin crosslinking protein IQGAP1 and the microtubule-stabilizing protein APC that impacts cells' ability to migrate into a wound.
Tirnauer
Jennifer S
JS
Center for Molecular Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
D000199:Actins / Q000378:metabolism*; D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism*; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D011485:Protein Binding; D034741:RNA, Small Interfering / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology*; D014945:Wound Healing; D020703:ras GTPase-Activating Proteins / Q000737:chemistry* / Q000378:metabolism
D000199:Actins; C101203:IQ motif containing GTPase activating protein 1; D034741:RNA, Small Interfering; D020703:ras GTPase-Activating Proteins; D049452:Green Fluorescent Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome