title: In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.
abstract: We performed in vitro antifungal checkerboard testing on 12 Aspergillus fumigatus clinical isolates (6 transplant recipients and 6 nontransplant patients) with three antifungal agents (amphotericin B, voriconazole, and caspofungin) and three immunosuppressants (FK506, cyclosporine, and rapamycin). We were not able to detect a difference in calcineurin inhibitor antifungal activity against isolates from transplant recipients and nontransplant patients.
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA. stein022@mc.duke.edu
authors.forename: William J
authors.initials: WJ
authors.lastname: Steinbach
authors.forename: Nina
authors.initials: N
authors.lastname: Singh
authors.forename: Jackie L
authors.initials: JL
authors.lastname: Miller
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Benjamin
authors.forename: Wiley A
authors.initials: WA
authors.lastname: Schell
authors.forename: Joseph
authors.initials: J
authors.lastname: Heitman
authors.forename: John R
authors.initials: JR
authors.lastname: Perfect
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects*; D065095:Calcineurin Inhibitors; D000077336:Caspofungin; D016572:Cyclosporine / Q000494:pharmacology; D054714:Echinocandins; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D055666:Lipopeptides; D016377:Organ Transplantation; D010456:Peptides, Cyclic / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D016559:Tacrolimus / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D065095:Calcineurin Inhibitors; D054714:Echinocandins; D007166:Immunosuppressive Agents; D055666:Lipopeptides; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D016572:Cyclosporine; D000077336:Caspofungin; D065819:Voriconazole; D016559:Tacrolimus