title: A systems view of mRNP biology.
abstract: Gene expression occurs through a complex mRNA-protein (mRNP) system that stretches from transcription to translation. Gene expression processes are increasingly studied from global perspectives in order to understand their pathways, properties, and behaviors as a system. Here we review these beginnings of mRNP systems biology, as they have emerged from recent large-scale investigation of mRNP components, interactions, and dynamics. Such work has begun to lay the foundation for a broader, integrated view of mRNP organization in gene expression.
authors.affiliation: Department of Systems Biology, Harvard Medical School and the Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: Haley
authors.initials: H
authors.lastname: Hieronymus
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Silver
mesh_terms: D014176:Protein Biosynthesis / Q000502:physiology; D012333:RNA, Messenger / Q000502:physiology*; D012261:Ribonucleoproteins / Q000502:physiology*; D049490:Systems Biology; D014158:Transcription, Genetic / Q000502:physiology
chemical_list: D012333:RNA, Messenger; D012261:Ribonucleoproteins