title: [Sevelamer hydrochloride prevents ectopic calcification of blood vessels].
abstract: Sevelamer hydrochloride is a non-absorbed calcium- and metal-free phosphate binder that lowers the serum phosphorus levels in hemodialysis patients. Sevelamer contains multiple amines, which are partially protonated and interact with phosphate molecules through ionic and hydrogen bonding. We show the in vitro phosphate binding assay data and the efficacy of sevelamer to lower the serum phosphorus and calcium phosphorus product in several animal models. Furthermore, we indicate the vivid data that sevelamer prevented the ectopic calcification of aorta in adenine induced renal failure model, which represent severe hyperphosphatemia and the related dialysis complications.
authors.affiliation: Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.
authors.forename: Naoshi
authors.initials: N
authors.lastname: Fukushima
authors.forename: Nobuo
authors.initials: N
authors.lastname: Nagano
mesh_terms: D000327:Adsorption; D000818:Animals; D001011:Aorta; D002118:Calcium / Q000097:blood; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004852:Epoxy Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006860:Hydrogen Bonding; D007477:Ions; D007676:Kidney Failure, Chronic / Q000150:complications; D009999:Ossification, Heterotopic / Q000209:etiology / Q000517:prevention & control*; D010758:Phosphorus / Q000097:blood; D010760:Phosphorus Metabolism Disorders / Q000209:etiology / Q000517:prevention & control; D011073:Polyamines; D011095:Polyethylenes / Q000494:pharmacology / Q000627:therapeutic use*; D006435:Renal Dialysis / Q000009:adverse effects; D012307:Risk Factors; D000069603:Sevelamer
chemical_list: D004852:Epoxy Compounds; D007477:Ions; D011073:Polyamines; D011095:Polyethylenes; D010758:Phosphorus; D000069603:Sevelamer; D002118:Calcium