[Efficiency of voriconazole in fungal keratitis caused by candida albicans].
METHODS
A 70-year-old woman, with a history of diabetes and persistent corneal ulceration, developed a severe keratitis caused by Candida albicans. It evolved rapidly to corneal perforation in spite of treatment with topical amphotericin B and oral itraconazole. An amniotic membrane transplant was performed as an emergency, associated with systemic administration of voriconazole. The infection was solved successfully, although the patient needed a penetrating keratoplasty to restore the corneal transparency.


CONCLUSIONS
Fungal keratitis caused by Candida albicans usually follows an aggressive course and may simulate a bacterial aetiology. Voriconazole is a new antifungal drug that appears to be very effective in the management of ocular infections caused by many filamentous and levaduriform fungi.
Granados
J M
JM
Servicio de Oftalmología, Complejo Hospitalario Universitario de Albacete (SESCAM), Spain. jgranadosm@ono.com
Puerto
N
N
Carrilero
M J
MJ
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007634:Keratitis / Q000188:drug therapy* / Q000382:microbiology*; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole