title: Multi-scale methodology: a key to deciphering systems biology.
abstract: Presently, it is widely accepted complex systems couldn't be comprehended by studying parts in isolation without examining integrative and emergent properties, and system-level understanding thus has become the focus in biological science. However, it should also be noted that common systematic analysis was restricted to large-scale analysis at a certain level, while the facts that the nature of complex systems is their multi-scale structures was usually neglected or ignored. Therefore, this paper described a multi-scale methodology to investigate the nature of biological complexity and prospected this methodology could lead to a promising revolution in current system-level understanding and the integration of molecular biology databases.
authors.affiliation: State Key Laboratory of Bioreactor Engineering, National Engineer Research Center for Biotechnology, Department of Biochemical Engineering, East China University of Science and Technology, Shanghai 200237, China PR. siliangz@163.net <siliangz@163.net>
authors.forename: Xinhao
authors.initials: X
authors.lastname: Ye
authors.forename: Ju
authors.initials: J
authors.lastname: Chu
authors.forename: Yinping
authors.initials: Y
authors.lastname: Zhuang
authors.forename: Siliang
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001695:Biology / Q000379:methods; D019295:Computational Biology / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D008967:Molecular Biology; D049490:Systems Biology / Q000379:methods*; D018511:Systems Integration