Organogenesis: cutting to the chase.
Gonad morphogenesis in Caenorhabditis elegans requires two secreted proteases. Recent studies show that alterations of the extracellular matrix component fibulin-1 rescue gonadogenesis in the absence of these proteases. This finding is a critical step toward understanding the role of extracellular matrix in organogenesis.
Meighan
Christopher M
CM
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Cram
Erin J
EJ
Schwarzbauer
Jean E
JE
D000818:Animals; D017173:Caenorhabditis elegans / Q000254:growth & development*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism*; D006066:Gonads / Q000254:growth & development*; D008666:Metalloendopeptidases / Q000378:metabolism; D038081:Organogenesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D029742:Caenorhabditis elegans Proteins; D002135:Calcium-Binding Proteins; C060820:fibulin; C119674:GON-1 protein, C elegans; D008666:Metalloendopeptidases