title: Simulation modeling of change to breast cancer detection age eligibility recommendations in Ontario, 2002-2021.
abstract: OBJECTIVE
  The purpose of this project was to demonstrate the development and use of a decision support tool based on simulation modeling of breast cancer screening to evaluate the implications for the provision of health services and the economic impact of extending routine radiographic screening for breast cancer to women in the 40-49 age group between 2002 and 2021.
  
  
  METHODS
  The main method was computer simulation with a Markov model that used published estimates of population size by age group, breast cancer prevalence and incidence, screening program participation rate, sensitivity and specificity of the screening test and diagnostic test, stage transition probabilities, directed diagnosis rates and costs.
  
  
  RESULTS
  The model predicted that changes to age eligibility requirements would result in the detection of an additional 6610 women with breast cancer in Ontario requiring treatment, at an additional cost of 795 Canadian per case. These costs include those related to screening, diagnosis and initial treatment and apply to the 20-year period.
  
  
  CONCLUSIONS
  The model provided a useful decision support tool for those planning and implementing breast cancer screening programs.
authors.affiliation: Center for Health Services and Policy Research, Department of Community Health and Epidemiology, Abramsky Hall, Queen's University, Kingston, Ontario, Canada K7L 3A6. hunter@post.queensu.ca
authors.forename: Duncan J W
authors.initials: DJ
authors.lastname: Hunter
authors.forename: Sean M
authors.initials: SM
authors.lastname: Drake
authors.forename: Samuel E D
authors.initials: SE
authors.lastname: Shortt
authors.forename: John L
authors.initials: JL
authors.lastname: Dorland
authors.forename: Ninh
authors.initials: N
authors.lastname: Tran
mesh_terms: D000367:Age Factors; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000191:economics; D003198:Computer Simulation; D003661:Decision Support Techniques; D005260:Female; D017048:Health Care Costs; D006287:Health Planning Guidelines; D006801:Humans; D008390:Markov Chains; D008403:Mass Screening; D008875:Middle Aged; D009864:Ontario