title: Spina bifida.
abstract: Spina bifida results from failure of fusion of the caudal neural tube, and is one of the most common malformations of human structure. The causes of this disorder are heterogeneous and include chromosome abnormalities, single gene disorders, and teratogenic exposures. However, the cause is not known in most cases. Up to 70% of spina bifida cases can be prevented by maternal, periconceptional folic acid supplementation. The mechanism underlying this protective effect is unknown, but it is likely to include genes that regulate folate transport and metabolism. Individuals with spina bifida need both surgical and medical management. Although surgical closure of the malformation is generally done in the neonatal period, a randomised clinical trial to assess in utero closure of spina bifida has been initiated in the USA. Medical management is a lifelong necessity for individuals with spina bifida, and should be provided by a multidisciplinary team.
authors.affiliation: Institute of Bioscience and Technology, The Texas A&M University System Health Science Center, TX 77030-3303, USA. lmitchell@ibt.tamhsc.edu
authors.forename: Laura E
authors.initials: LE
authors.lastname: Mitchell
authors.forename: N Scott
authors.initials: NS
authors.lastname: Adzick
authors.forename: Jeanne
authors.initials: J
authors.lastname: Melchionne
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Pasquariello
authors.forename: Leslie N
authors.initials: LN
authors.lastname: Sutton
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Whitehead
mesh_terms: D000818:Animals; D005260:Female; D046128:Fetal Therapies; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012307:Risk Factors; D016135:Spinal Dysraphism / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000517:prevention & control