title: Aminophylline as an adjunct diuretic for neonates--a case series.
abstract: Aminophylline is an adenosine receptor antagonist. Adult and paediatric studies have demonstrated a diuretic effect of aminophylline due to increased renal blood flow and the inhibition of solute reabsorption in various segments of the nephron. We report a case series of five infants with volume overload despite frusemide treatment. Aminophylline was successfully used as an adjunct diuretic with increased urine output and effective weight loss occurring in all five neonates following its introduction.
authors.affiliation: Department of Neonatology, Neonatal Intensive Care Unit, St George's Hospital, Blackshaw Road, Tooting, London SW17 0RE, UK. drgytng@aol.com
authors.forename: Geraldine Yin Taeng
authors.initials: GY
authors.lastname: Ng
authors.forename: Emma Harriet
authors.initials: EH
authors.lastname: Baker
authors.forename: Katharine Florence Mary
authors.initials: KF
authors.lastname: Farrer
mesh_terms: D000628:Aminophylline / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012189:Retrospective Studies; D014883:Water-Electrolyte Imbalance / Q000188:drug therapy*
chemical_list: D004232:Diuretics; D000628:Aminophylline