[The distribution of HLA alleles class I and class II among patientes with psoriatic arthritis in Croatia].
The aim of the present study was to analyze the distribution of HLA-A, -B, -Cw, and -DRB1 alleles among patients with psoriatic arthritis (PsA) in Croatia. DNA was isolated from peripheral blood of 58 PsA patients (28 male and 30 female) and tested by PCR-SSP (Polymerase Chain Reaction - Sequence Specific Primers) method for polymorphism of the above mentioned HLA loci. The strongest association between psoriatic arthritis and HLA in the Croatian population was observed for alleles at HLA-B locus (B*39 and B*57), while the association of B*27 and B* 13 alleles with PsA reached significance only before correction of p value with the number of tested alleles. Higher frequency of Cw*02 and DRB1*16 alleles is a result of linkage disequilibrium between these alleles and HLA-B alleles associated with PsA in Croatia. We also observed lower frequency of B*0702, B*18 and B*38 alleles in our group of patients.
Grubić
Zorana
Z
Zavod za tipizaciju tkiva, Zagreb. zgrubic@kbc-zagreb.hr
Perić
Porin
P
Cecuk-Jelicić
Esma
E
Zunec
Renata
R
Curković
Bozidar
B
Kerhin-Brkljacić
Vesna
V
D000483:Alleles; D015535:Arthritis, Psoriatic / Q000235:genetics* / Q000276:immunology; D017523:Croatia; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II