Biosynthesis of pantothenate.
Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea. This suggests that the pathway is a strong candidate for the discovery of novel antibiotic and herbicidal compounds. The enzymology of this short pathway in both bacteria and plants is discussed in detail. In addition a short survey of studies of the whole pathway, and a discussion of both the metabolism and the transport of pantothenate are included.
Webb
Michael E
ME
University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. mew23@cantab.net
Smith
Alison G
AG
Abell
Chris
C
D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D001419:Bacteria / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010205:Pantothenic Acid / Q000096:biosynthesis*; D010453:Peptide Synthases / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D020539:Sequence Analysis, Protein
D010205:Pantothenic Acid; D010453:Peptide Synthases; C022318:pantothenate synthetase