The Paris-Sud yeast structural genomics pilot-project: from structure to function.
We present here the outlines and results from our yeast structural genomics (YSG) pilot-project. A lab-scale platform for the systematic production and structure determination is presented. In order to validate this approach, 250 non-membrane proteins of unknown structure were targeted. Strategies and final statistics are evaluated. We finally discuss the opportunity of structural genomics programs to contribute to functional biochemical annotation.
Quevillon-Cheruel
Sophie
S
Institut de Biochimie et de Biophysique Moléculaire et Cellulaire (CNRS-UMR 8619), Université Paris-Sud, Bâtiment 430, 91405 Orsay, France.
Liger
Dominique
D
Leulliot
Nicolas
N
Graille
Marc
M
Poupon
Anne
A
Li de La Sierra-Gallay
Inès
I
Zhou
Cong-Zhao
CZ
Collinet
Bruno
B
Janin
Joël
J
Van Tilbeurgh
Herman
H
D023281:Genomics; D011487:Protein Conformation; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry
D029701:Saccharomyces cerevisiae Proteins