title: Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.
abstract: A new ubiquitin-activating enzyme (E1) inhibitor, himeic acid A, was isolated from a culture of marine-derived fungus, Aspergillus sp. The structure was determined by spectroscopic analysis. The formation of an E1-ubiquitin (Ub) intermediate was 65% inhibited by himeic acid A at the concentration of 50 microM, while two new related compounds, himeic acids B and C, showed little inhibitory activity even at 100 microM.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920-1192, Japan. sachiko@p.kanakawa-u.ac.jp
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirota
authors.forename: Misako
authors.initials: M
authors.lastname: Imachi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fujimuro
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Onuki
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Ohta
authors.forename: Hideyoshi
authors.initials: H
authors.lastname: Yokosawa
mesh_terms: D001230:Aspergillus / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology*; D008386:Marine Biology; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D044764:Ubiquitin-Activating Enzymes / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D005231:Fatty Acids, Unsaturated; D011753:Pyrones; C500027:himeic acid A; D044764:Ubiquitin-Activating Enzymes