[Mechanism of vascular calcification].
Vascular calcification in dialysis patients is associated with morbidity and mortality risks. Recent evidence suggests that vascular calcification is an active process resembling osteogenesis and chondrogenesis process. In this process, hyperphosphatemia is one of the important regulators. Inorganic phosphates directly regulate vascular calcification in vitro through a sodium-dependent phosphate cotransporter and promote expression of the osteoblastic differentiation markers.
Kizu
Akane
A
Department Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine.
Jono
Shuichi
S
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D002114:Calcinosis / Q000209:etiology*; D002135:Calcium-Binding Proteins / Q000502:physiology; D003956:Dialysis / Q000009:adverse effects; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006801:Humans; D009363:Neoplasm Proteins / Q000502:physiology; D053495:Osteopontin; D010758:Phosphorus / Q000097:blood / Q000502:physiology*; D010760:Phosphorus Metabolism Disorders / Q000150:complications*; D012306:Risk; D012795:Sialoglycoproteins / Q000502:physiology; D050608:Sodium-Phosphate Cotransporter Proteins; D027981:Symporters / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D014652:Vascular Diseases / Q000209:etiology*; D000097568:Matrix Gla Protein
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D009363:Neoplasm Proteins; D053495:Osteopontin; D010758:Phosphorus; D012795:Sialoglycoproteins; D050608:Sodium-Phosphate Cotransporter Proteins; D027981:Symporters; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D000097568:Matrix Gla Protein; C525718:BMP2 protein, human; C506895:SPP1 protein, human