title: The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.
abstract: In Candida albicans, calcineurin is essential for virulence and survival during membrane perturbation by azoles. Crz1 is a proposed downstream target of calcineurin based on studies of Saccharomyces cerevisiae. However, the in vitro phenotypes of C. albicans crz1/crz1 and calcineurin mutants differ and Crz1 is not required for virulence.
authors.affiliation: Department of Molecular Genetics and Microbiology, 322 Carl Building, Box 3546, Research Drive, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Chiatogu
authors.initials: C
authors.lastname: Onyewu
authors.forename: Floyd L
authors.initials: FL
authors.lastname: Wormley
authors.forename: John R
authors.initials: JR
authors.lastname: Perfect
authors.forename: Joseph
authors.initials: J
authors.lastname: Heitman
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D019703:Calcineurin / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000472:pathogenicity*; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D016559:Tacrolimus / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole; D019703:Calcineurin; D016559:Tacrolimus