[Present data on influenza virus isolated from ducks and chickens, and influenza virus C. Anti-influenza drugs].
Present data on influenza virus isolated from ducks and chickens, and influenza virus C. Anti-influenza drugs. Within the broad field of Glycopathology and Glycotherapeutics, research on influenza virus types A, B and C from humans and several bird species (particularly migratory birds such as ducks, since they are reservoirs for viruses), as well as the search for improved drugs designed for the prevention or treatment of epidemics/pandemics produced by most of those viruses are issues of relevant interest not only from a scientific point of view but also for repercussions on health and the important economical consequences. The research work begun by the author and collaborators at the Department of Biochemistry and Molecular Biology of the University of Salamanca (Spain) in the middle of the 1970's, developed later in close cooperation with the "(Unité d'Ecologie Virale" of the Pasteur Institute of Paris (Prof. Claude Hannoun and collaborators), has been published in about twenty papers that mainly focus on the theoretic-experimental study of: The sialidase (neuraminidase) activity of human influenza viruses types A and B. The acetylesterase activity of type C virus from humans and dogs. The sialidase activity of type A virus from ducks and pigs, in comparison with that of humans. Certain sialidase inhibitors as useful anti-influenza drugs, especially in the case of possible future influenza pandemics of avian origin.
Fernández del Campo
José Antonio Cabezas
JA
Académico de Número de la Real Academia Nacional de Farmacia Catedrático Emérito de la Universidad de Salamanca.
D000115:Acetylesterase / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D002645:Chickens / Q000382:microbiology*; D002648:Child; D002675:Child, Preschool; D004197:Disease Reservoirs; D004285:Dogs; D004372:Ducks / Q000382:microbiology*; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage; D005585:Influenza in Birds / Q000188:drug therapy*; D007251:Influenza, Human / Q000188:drug therapy* / Q000517:prevention & control; D029521:Alphainfluenzavirus / Q000201:enzymology / Q000302:isolation & purification; D029524:Betainfluenzavirus / Q000201:enzymology / Q000302:isolation & purification; D009982:Gammainfluenzavirus / Q000201:enzymology / Q000302:isolation & purification; D008875:Middle Aged; D009439:Neuraminidase / Q000032:analysis / Q000037:antagonists & inhibitors*; D009975:Orthomyxoviridae / Q000302:isolation & purification*; D012106:Research
D000998:Antiviral Agents; D007252:Influenza Vaccines; D000115:Acetylesterase; D009439:Neuraminidase