title: Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse.
abstract: Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. Our studies have focused on mouse models where circulating IGF-1 levels are reduced, while tissue expression of IGF-1 is normal. These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth.
authors.affiliation: Diabetes Branch, Room 8D12, Building 10, National Institutes of Health, MSC 1758, Bethesda MD 20892-1758, USA.
authors.forename: Shoshana
authors.initials: S
authors.lastname: Yakar
authors.forename: Patricia
authors.initials: P
authors.lastname: Pennisi
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Derek
authors.initials: D
authors.lastname: LeRoith
mesh_terms: D000818:Animals; D017353:Gene Deletion; D007334:Insulin-Like Growth Factor I / Q000235:genetics* / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000378:metabolism*
chemical_list: D007334:Insulin-Like Growth Factor I