title: Integrin-growth factor interactions as regulators of oligodendroglial development and function.
abstract: Central nervous system (CNS) development requires mechanisms for the regulation of cell number. Although growth factors are essential determinants of the proliferation and apoptosis that determine final numbers, the long-range nature of signals from diffusible growth factors makes them insufficient for the provision of the precise and localized signals required. Integration of integrin and growth factor receptor signaling in controlling cell behavior has been an important theme of research over the past several years. The focus of this review is on the mechanisms by which integrin-growth factor interactions regulate the development of oligodendrocytes and provide a mechanism for controlling, both in space and in time, oligodendrocyte numbers in the developing CNS.
authors.affiliation: Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, Groningen, The Netherlands. w.baron@med.rug.nl
authors.forename: Wia
authors.initials: W
authors.lastname: Baron
authors.forename: Holly
authors.initials: H
authors.lastname: Colognato
authors.forename: Charles
authors.initials: C
authors.lastname: ffrench-Constant
authors.forename: Charles
authors.initials: C
authors.lastname: Ffrench-Constant
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology; D049109:Cell Proliferation; D002490:Central Nervous System / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D009836:Oligodendroglia / Q000166:cytology / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D006133:Growth Substances; D016023:Integrins