title: S-100 protein immunoreactivity in the upper eyelid of the sheep Ovis aries.
abstract: The aim of this work was to analyse the distribution pattern of S-100-immunoreactive elements in the upper eyelid of the sheep. This pattern may be of importance regarding the diagnosis and prognosis of eyelid tumours that are linked to deregulation of S-100 gene expression. Thirty upper eyelids taken from 15 adult male Ovis aries were studied by means of the peroxidase-antiperoxidase method for light microscopy. S-100-immunopositive cells were found in the eyelid edge. S-100-immunopositive steams and thinner fibres were found throughout the eyelid. These nerve processes typically were denser around glands, hair follicles and blood vessels. S-100-immunopositive elements may play a role as neuromodulator and also in the development of the vegetative innervation of the epithelium and its derivatives.
authors.affiliation: Department of Human Anatomy and Histology, School of Medicine, University of Zaragoza, 50.009 Zaragoza, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Aisa
authors.forename: M
authors.initials: M
authors.lastname: Lahoz
authors.forename: P
authors.initials: P
authors.lastname: Serrano
authors.forename: M C
authors.initials: MC
authors.lastname: Pérez-Castejón
authors.forename: C
authors.initials: C
authors.lastname: Junquera
authors.forename: M C
authors.initials: MC
authors.lastname: Martínez-Ciriano
authors.forename: N
authors.initials: N
authors.lastname: Pes
authors.forename: A
authors.initials: A
authors.lastname: Vera-Gil
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000378:metabolism; D005142:Eyelid Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D005143:Eyelids / Q000098:blood supply / Q000294:innervation / Q000378:metabolism*; D005786:Gene Expression Regulation; D018859:Hair Follicle / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D010525:Peripheral Nerves / Q000378:metabolism*; D009418:S100 Proteins / Q000378:metabolism*; D012756:Sheep
chemical_list: D009418:S100 Proteins