Memory complaints in nondemented men predict future pathologic diagnosis of Alzheimer disease.
The validity of memory complaints as a predictor of Alzheimer disease (AD) was assessed in 237 Japanese-American men autopsied at ages 74 to 97 years. These men were free of dementia at the time memory complaints were assessed 1 to 11 years earlier. Memory complaints were found to predict the neuropathologic diagnosis of AD after adjusting for age, time to death, education, depression, and cognitive functioning.
Jorm
A F
AF
Centre for Mental Health Research, Australian National University, Canberra, ACT 0200, Australia. Anthony.Jorm@anu.edu.au
Masaki
K H
KH
Davis
D G
DG
Hardman
J
J
Nelson
J
J
Markesbery
W R
WR
Petrovitch
H
H
Ross
G W
GW
White
L R
LR
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology*; D001071:Appointments and Schedules; D001213:Asian; D015331:Cohort Studies; D003863:Depression / Q000453:epidemiology; D018450:Disease Progression; D004522:Educational Status; D005145:Face; D005500:Follow-Up Studies; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008569:Memory Disorders / Q000453:epidemiology*; D009275:Names; D016017:Odds Ratio; D011446:Prospective Studies; D011581:Psychological Tests; D012307:Risk Factors