[Morphological alterations of the rat myocardium in chronic morphine intoxication].
Morphine was administered intraperitoneally to Wistar rats at increasing doses from 10 to 60 mg pay during 8 days. Cardiomyocyte damage in the form of myocytolysis and wave-like deformations of muscle fibers prevailed at the level of light microscopy. Microcirculatory alterations were characteristic: stasis, sludge-phenomenon, perivascular and interstitial oedema, diapedes hemorrhages, focal proliferation of vascular wall cells. Ultrastructural lesions were as follows: subsarcolemma edema, mitochondrial destruction, formation of giant forms of mitochondria, single contractures, increasing micropinocytosis, intestitial edema.
Lun'kova
L K
LK
Makarova
O V
OV
Kakturskiĭ
L V
LV
Chernikov
V P
VP
Sudakov
S K
SK
Mkhitarov
V A
VA
D000818:Animals; D008297:Male; D008833:Microcirculation / Q000473:pathology / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D008929:Mitochondria, Heart / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D009020:Morphine / Q000008:administration & dosage / Q000633:toxicity*; D009021:Morphine Dependence / Q000150:complications / Q000473:pathology*; D018485:Muscle Fibers, Skeletal / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure*; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar
D009020:Morphine