title: Biology of the lymphatic marker LYVE-1 and applications in research into lymphatic trafficking and lymphangiogenesis.
abstract: The pace of research into the lymphatic system continues to accelerate with the availability of new molecular markers. One such marker, LYVE-1, the lymphatic receptor for the extracellular matrix mucopolysaccharide hyaluronan, has been a key component of many important studies on embryonic and tumour-induced lymphangiogenesis, and continues to be used for the detection and isolation of lymphatic endothelial cells. However, LYVE-1 is interesting in its own right. Being a member of the Link protein family whose only other major hyaluronan receptor is directly involved in leukocyte migration and tumour metastasis, LYVE-1 is already implicated in the trafficking of cells within lymphatic vessels and lymph nodes. The current challenge is to determine the precise roles played by LYVE-1 and other scavenger type receptors in the immune functions of the lymphatics as well as to use LYVE-1 and other markers to investigate the way in which tumours exploit lymphatic vessels for metastasis.
authors.affiliation: MRC Human Immunology Unit, Weatherall Institute for Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK. djackson@hammer.imm.ox.ac.uk
authors.forename: David G
authors.initials: DG
authors.lastname: Jackson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015415:Biomarkers; D002465:Cell Movement; D006023:Glycoproteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D018960:Hyaluronan Receptors / Q000737:chemistry / Q000502:physiology; D006820:Hyaluronic Acid / Q000378:metabolism; D042583:Lymphangiogenesis; D042601:Lymphatic Vessels / Q000166:cytology*; D008969:Molecular Sequence Data; D009362:Neoplasm Metastasis; D033921:Vesicular Transport Proteins
chemical_list: D015415:Biomarkers; D006023:Glycoproteins; D018960:Hyaluronan Receptors; C119248:LYVE1 protein, human; D033921:Vesicular Transport Proteins; D006820:Hyaluronic Acid