BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis.
Blood samples from 132 consecutive hematopoietic stem cell transplant recipients were obtained and tested weekly for BK virus DNA by use of quantitative real-time PCR. Forty-four patients (33%) developed BK viremia at a median of 41 days (range, 9-91 days) after transplantation. Patients with hemorrhagic cystitis that occurred after platelet engraftment had higher levels of viremia than did patients without hemorrhagic cystitis (median, 9.7x10(3) vs. 0 copies/mL; P=.008) and patients with hemorrhagic cystitis that occurred before platelet engraftment (median, 9.7x10(3) vs. 0 copies/mL; P=.0006). BK viremia also was strongly associated with postengraftment hemorrhagic cystitis in a time-dependent analysis (P=.004).
Erard
Veronique
V
Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
Storer
Barry
B
Corey
Lawrence
L
Nollkamper
Jennifer
J
Huang
Meei-Li
ML
Limaye
Ajit
A
Boeckh
Michael
M
D001739:BK Virus; D003556:Cystitis / Q000503:physiopathology*; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006412:Hematopoietic Stem Cells; D006470:Hemorrhage / Q000503:physiopathology*; D006801:Humans; D027601:Polyomavirus Infections / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors