Cyclic sulfamidates as vehicles for the synthesis of substituted lactams.
[reaction: see text] A structurally diverse series of mono- and disubstituted 1,2- and 1,3-cyclic sulfamidates react with stabilized enolates, including malonate and phosphonoacetate variants, to provide, after lactamization, substituted and alpha-functionalized pyrrolidinone and piperidinone derivatives.
Bower
John F
JF
School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.
Svenda
Jakub
J
Williams
Andrew J
AJ
Charmant
Jonathan P H
JP
Lawrence
Ron M
RM
Szeto
Peter
P
Gallagher
Timothy
T