Effect of neuropeptide Y microinjected into the hypothalamus on ethanol consumption.
Guide cannula were implanted in rats aimed at the paraventricular nucleus (PVN) of the hypothalamus for microinjection of neuropeptide Y (NPY), D-NPY27-36, or vehicle. In the Wistar rat, there was no significant effect on the consumption of ethanol. In Myers' high ethanol preferring (mHEP) rats, D-NPY27-36 caused a significant 54% decrease in ethanol consumption from baseline, but the response was not different from vehicle. NPY-induced feeding in satiated Wistar rats, was blocked by a Y1 receptor antagonist, D-NPY27-3). D-NPY27-36 decreased 78% feeding in food-deprived rats. Thus, neither the Wistar nor the mHEP rat perceives ethanol as a source of calories comparable to food.
Lucas
L A C
LA
Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27838, USA.
McMillen
B A
BA
D000428:Alcohol Drinking / Q000188:drug therapy*; D000818:Animals; D004435:Eating / Q000187:drug effects; D005508:Food Deprivation; D008297:Male; D008845:Microinjections; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D009478:Neuropeptide Y; D010446:Peptide Fragments; C095005:neuropeptide Y (27-36), Tyr(27,36)-Thr(32)-