title: Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine.
abstract: A 94C>A missense mutation in the ITPA gene which encodes inosine triphosphate pyrophosphatase has been associated with adverse effects from azathioprine, specifically flu-like symptoms, pancreatitis and rash. We hypothesized that this association may also be present in a larger, population-based group of inflammatory bowel disease patients intolerant of thiopurine drugs. We performed genotyping for this polymorphism and TPMT*2 and TPMT*3 in 73 such patients and 74 patients with inflammatory bowel disease who have tolerated azathioprine. We could not demonstrate a significant association between the ITPA94C>A genotype and any adverse effects (Odds ratio (OR) 1.015, 95% confidence interval (CI) 0.360-2.867, P = 0.593), flu-like symptoms (OR 1.547, 95%CI 0.368-6.496, P = 0.398), rash (no ITPA 94C>A polymorphism identified) or pancreatitis (no ITPA 94C>A polymorphism identified). We found no significant association between the ITPA 94C>A polymorphism and adverse effects to thiopurine drugs.
authors.affiliation: Department of Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand. richard.geary@cdhb.govt.nz
authors.forename: Richard B
authors.initials: RB
authors.lastname: Gearry
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Roberts
authors.forename: Murray L
authors.initials: ML
authors.lastname: Barclay
authors.forename: Martin A
authors.initials: MA
authors.lastname: Kennedy
mesh_terms: D001379:Azathioprine / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D011755:Pyrophosphatases / Q000235:genetics*; D000097630:Inosine Triphosphatase
chemical_list: D001379:Azathioprine; D007166:Immunosuppressive Agents; D011755:Pyrophosphatases; D000097630:Inosine Triphosphatase