title: Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis--case report and literature review.
abstract: The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal. The literature was reviewed and meningitis due to Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients was demonstrated. Meningococcal disease may be the first manifestation of complement deficiency; screening for complement function must be considered for those with invasive meningococcal disease, with posterior evaluation of the components of the terminal pathway of complement.
authors.affiliation: Internal Medicine Department, Nossa Senhora da Conceição Hospital, Porto Alegre, Rio Grande do Sul, Brazil. ddrosa@terra.com.br
authors.forename: Daniela Dornelles
authors.initials: DD
authors.lastname: Rosa
authors.forename: Alessandro C
authors.initials: AC
authors.lastname: Pasqualotto
authors.forename: Maurício
authors.initials: M
authors.lastname: de Quadros
authors.forename: Sérgio Henrique
authors.initials: SH
authors.lastname: Prezzi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D003185:Complement C8 / Q000172:deficiency*; D006801:Humans; D008297:Male; D008585:Meningitis, Meningococcal / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents; D003185:Complement C8; D002443:Ceftriaxone