title: REALISIS: a medicinal chemistry-oriented reagent selection, library design, and profiling platform.
abstract: REALISIS is a software system for reagent selection, library design, and profiling, developed to fit the workflow of bench chemists and medicinal chemists. Designed to be portable, the software offers a comprehensive graphical user interface and rapid, integrated functionalities required for reagent retrieval and filtering, product enumeration, and library profiling. REALISIS is component-based, consisting of four main modules: reagent searching; reagent filtering; library enumeration; and library profiling. Each module allows the chemist to access specific functionalities and diverse filtering and profiling mechanisms. By implementing the entire process of reagent selection, library design, and profiling and by integrating all the necessary functionalities for this process, REALISIS cuts the time required to design combinatorial and noncombinatorial libraries from several days to a few hours.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, a division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B-23 40 Beerse, Belgium. yaziz_2000@yahoo.fr
authors.forename: Aziz
authors.initials: A
authors.lastname: Yasri
authors.forename: Didier
authors.initials: D
authors.lastname: Berthelot
authors.forename: Harry
authors.initials: H
authors.lastname: Gijsen
authors.forename: Theo
authors.initials: T
authors.lastname: Thielemans
authors.forename: Patrick
authors.initials: P
authors.lastname: Marichal
authors.forename: Michael
authors.initials: M
authors.lastname: Engels
authors.forename: Jan
authors.initials: J
authors.lastname: Hoflack