Stannylative cycloaddition of enynes catalyzed by palladium-iminophosphine.
Palladium-iminophosphine complex catalyzes stannylative cycloaddition of conjugated enynes using hexabutyldistannoxane as a stannylating agent to afford highly substituted 3-alkenylphenylstannanes regioselectively. Stannylative cross-cycloaddition reactions between different enynes or between enynes and diynes are also achieved. The reaction is successfully applied to a concise synthesis of alcyopterosin N, which has been isolated recently from sub-Antarctic soft coral, Alcyonium paessleri.
Nakao
Yoshiaki
Y
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510 Japan. nakao@npc05.kuic-u.ac.jp
Hirata
Yasuhiro
Y
Ishihara
Shinjiro
S
Oda
Shinichi
S
Yukawa
Tomoya
T
Shirakawa
Eiji
E
Hiyama
Tamejiro
T