Multi-chain immune recognition receptors: spatial organization and signal transduction.
Multi-chain immune recognition receptors (MIRRs) on T cells, B cells, mast cells and basophils function to transduce signals leading to a variety of biologic responses. These receptors are complexes formed by the association of immunoglobulin-like recognition subunits and signal-transducing subunits. How extracellular ligand binding initiates intracellular signal transduction processes is not clear, and little structural or biochemical information is available for the spatiotemporal organization of this key event in immune cell activation. Here, the current progress in studying this important aspect of cellular signaling is reviewed.
Sigalov
Alexander
A
Department of Pathology, S2-302, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Alexander.Sigalov@umassmed.edu
D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D021962:Membrane Microdomains / Q000276:immunology*; D011971:Receptors, Immunologic / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D011971:Receptors, Immunologic