[Injectable carrier system for growth factor application in minimally invasive stimulation of bone healing].
The characterization and cloning of growth factors for bone healing provide an enormous potential for minimally invasive treatment procedures for bone defects or fractures. However, the clinical application of injection vehicles for these growth factors must be made user-friendlier. In this study, two different injection vehicles were tested for their practicability and efficacy to enhance callus maturation during distraction osteogenesis. Calcium phosphate carriers showed a rather low user-friendliness and were less efficient in the animal model of distraction osteogenesis in sheep. Collagen carriers provided both a higher practicability for injection procedures and a higher efficacy.
Windhagen
H
H
Orthopädische Klinik der Medizinischen Hochschule Hannover. windhagen@annastift.de
Witte
F
F
Thorey
F
F
Hurschler
C
C
Wirth
C J
CJ
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage*; D001861:Bone Regeneration / Q000187:drug effects*; D002130:Calcium Phosphates; D003094:Collagen; D004337:Drug Carriers; D016267:External Fixators; D005260:Female; D017102:Fracture Healing / Q000502:physiology*; D018889:Ilizarov Technique; D007267:Injections; D014677:Pharmaceutical Vehicles; D011994:Recombinant Proteins / Q000008:administration & dosage; D012756:Sheep; D013977:Tibia / Q000000981:diagnostic imaging / Q000187:drug effects; D014057:Tomography, X-Ray Computed; D016212:Transforming Growth Factor beta / Q000008:administration & dosage*; D014783:Viscosity
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D002130:Calcium Phosphates; D004337:Drug Carriers; D014677:Pharmaceutical Vehicles; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D003094:Collagen; C020243:calcium phosphate