title: Preparation of axially chiral biphenyl diphosphine ligands and their application in asymmetric hydrogenation.
abstract: Axially chiral biphenyldiphosphine ligands bearing diphenylphosphino group(s) and/or dicyclohexylphosphino group(s) were prepared in enantiomerically pure form starting from 2,6-dimethylnitrobenzene via 8 steps: iodination, reduction, methoxylation through diazotization, Ullmann coupling, bromination, phosphorylation, optical resolution, and silane reduction, and the obtained ligands were used in rhodium-catalyzed asymmetric hydrogenation.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka, Japan. morimtt@u-shizuoka-ken.ac.jp
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Morimoto
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Masanao
authors.initials: M
authors.lastname: Murata
authors.forename: Naoko
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Achiwa
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D007202:Indicators and Reagents; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D010720:Phosphines / Q000737:chemistry*; D012238:Rhodium; D013237:Stereoisomerism
chemical_list: D001713:Biphenyl Compounds; D007202:Indicators and Reagents; D008024:Ligands; D010720:Phosphines; D012238:Rhodium