The motor disorder of classic Lesch-Nyhan disease.
Reports describing the neurological features of Lesch-Nyhan disease (LND) vary widely, thereby implying the involvement of different neurological substrates. The movement abnormalities in 20 patients with LND were investigated. Dystonia was the most frequent and severe movement disorder. At rest, hypotonia was more frequent than hypertonia. These findings are compatible with basal ganglia dysfunction in LND.
Visser
Jasper E
JE
Department Neurology, University Hospital St. Radboud, Nijmegen, The Netherlands.
Harris
James C
JC
Barabas
Gabor
G
Eddey
Gary E
GE
Jinnah
H A
HA
D006801:Humans; D007926:Lesch-Nyhan Syndrome / Q000175:diagnosis* / Q000473:pathology*; D009123:Muscle Hypotonia / Q000175:diagnosis; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000473:pathology; D009468:Neuromuscular Diseases / Q000175:diagnosis* / Q000473:pathology