[Expression and correlation with metastasis of E-cadherin, CD44H, matrix metalloproteinase-3, nm23H1 and VEGF in nasopharyngeal carcinoma].
OBJECTIVE
To investigate the expression of E-cadherin, CD44H, matrix metalloproteinase-3, nm23H1 and VEGF in nasopharyngeal carcinoma and its relationship to the metastasis.


METHODS
The expression of E-cadherin, CD44H, matrix metalloproteinase-3, nm23H1 and VEGF in 62 patients with nasopharyngeal carcinoma was detected by immunohistochemical SP method.


RESULTS
In the group of nasopharyngeal carcinoma with lymph node metastasis, the expression of E-cadherin and nm23H1 reduced and the expression of CD44H and MMP-3 increased, and there were respectively significant difference compared to the group of non-lymph node metastasis, but there wasn't significant difference between the two groups in VEGF. Furthermore, expression of E-cadherin was inversely correlated with that of CD44H and MMP-3, and the expression of CD44H was positively correlated with that of MMP-3. In the group of nasopharyngeal carcinoma with distant metastasis, the expression of E-cadherin and nm23H1 also increased and the expression of CD44H, MMP-3 and VEGF all increased. Compared with the group of negative distant metastasis, there were respectively significant difference. In addition, there was a positive correlation between the expression of CD44H and VEGF.


CONCLUSIONS
E-cadherin, CD44H, matrix metalloproteinase-3 and nm23H1 genes are closely related with lymph node and distant metastasis of nasopharyngeal carcinoma, while VEGF gene only relates to lymph node metastasis. They are important factors acting on metastasis of neoplasms.
Wang
Shuangle
S
Department of Otolaryngology-Head and Neck Surgery, Shantou City Central Hospital, Shantou, 515031, China.
Jiang
Yuanshi
Y
Huang
Hecheng
H
Yang
Qiang
Q
D000293:Adolescent; D000328:Adult; D000368:Aged; D015820:Cadherins / Q000096:biosynthesis*; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis*; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000096:biosynthesis*; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009362:Neoplasm Metastasis; D009701:Nucleoside-Diphosphate Kinase / Q000096:biosynthesis* / Q000235:genetics; D042442:Vascular Endothelial Growth Factors / Q000096:biosynthesis*
D015820:Cadherins; D018960:Hyaluronan Receptors; D054778:NM23 Nucleoside Diphosphate Kinases; D042442:Vascular Endothelial Growth Factors; D009701:Nucleoside-Diphosphate Kinase; D019278:Matrix Metalloproteinase 3