title: [Gd-AAZTA]-: a new structural entry for an improved generation of MRI contrast agents.
abstract: An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex [Gd(AAZTA)]- shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents.
authors.affiliation: Dipartimento di Chimica IFM, Università degli Studi di Torino, Via P. Giuria 7, I-10125 Torino, Italy. silvio.aime@unito.it
authors.forename: Silvio
authors.initials: S
authors.lastname: Aime
authors.forename: Luisella
authors.initials: L
authors.lastname: Calabi
authors.forename: Camilla
authors.initials: C
authors.lastname: Cavallotti
authors.forename: Eliana
authors.initials: E
authors.lastname: Gianolio
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Giovenzana
authors.forename: Pietro
authors.initials: P
authors.lastname: Losi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Maiocchi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Palmisano
authors.forename: Massimo
authors.initials: M
authors.lastname: Sisti
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005682:Gadolinium / Q000737:chemistry*; D008024:Ligands; D008279:Magnetic Resonance Imaging; D008968:Molecular Conformation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D003287:Contrast Media; D008024:Ligands; D009942:Organometallic Compounds; D005682:Gadolinium