[Cardiovascular effects of SERM].
Raloxifene has an estrogenic effect on the cardio-vascular system. In vascular endothelium, both clinical and basic studies show that raloxifene induces the synthesis and release of nitric oxide. In vascular smooth muscle, basic study shows that raloxifene attenuates the PDGF-induced cell proliferation by both induction of apoptosis and arrest of the cell cycle. We now await the results of currently ongoing prospective large scale randomized control trial, Raloxifene Use of The Heart.
Ohmichi
Masahide
M
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine.
Kawagoe
Jun
J
Abe
Akiko
A
Takahashi
Kazuhiro
K
Kurachi
Hirohisa
H
D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism; D004967:Estrogens / Q000819:agonists; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D017202:Myocardial Ischemia / Q000188:drug therapy; D009569:Nitric Oxide / Q000378:metabolism; D020849:Raloxifene Hydrochloride / Q000494:pharmacology* / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology* / Q000627:therapeutic use; D014664:Vasodilation / Q000187:drug effects
D004967:Estrogens; D020845:Selective Estrogen Receptor Modulators; D019938:Cyclin D1; D009569:Nitric Oxide; D020849:Raloxifene Hydrochloride