title: Prevalence of antibody to Bordetella pertussis antigens in serum specimens obtained from 1793 adolescents and adults.
abstract: Serum specimens were obtained from all subjects in the adolescent and adult acellular pertussis (aP) vaccine efficacy trial before and after immunization to study the prevalence of IgG and IgA antibody and geometric mean titers to 4 Bordetella pertussis antigens. Of 1793 adolescents and adult subjects who received aP vaccine, only 20%, 68%, 59%, and 39% had concentrations of IgG antibodies to pertussis toxin, filamentous hemagglutinin, pertactin, and fimbriae types 2 and 3, respectively, that were greater than or equal to the limit of quantitation of the enzyme-linked immunosorbent assay used in the analysis. There was minimal variation in antibody prevalence with respect to geographic area, age, sex, or race.
authors.affiliation: University of CaliforniaLos Angeles Center for Vaccine Research, Research and Education Institute, Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, USA. jcherry@mednet.ucla.edu <jcherry@mednet.ucla.edu>
authors.forename: James D
authors.initials: JD
authors.lastname: Cherry
authors.forename: Swei-Ju
authors.initials: SJ
authors.lastname: Chang
authors.forename: David
authors.initials: D
authors.lastname: Klein
authors.forename: Martin
authors.initials: M
authors.lastname: Lee
authors.forename: Steve
authors.initials: S
authors.lastname: Barenkamp
authors.forename: David
authors.initials: D
authors.lastname: Bernstein
authors.forename: Robert
authors.initials: R
authors.lastname: Edelman
authors.forename: Michael D
authors.initials: MD
authors.lastname: Decker
authors.forename: David P
authors.initials: DP
authors.lastname: Greenberg
authors.forename: Wendy
authors.initials: W
authors.lastname: Keitel
authors.forename: John
authors.initials: J
authors.lastname: Treanor
authors.forename: Joel I
authors.initials: JI
authors.lastname: Ward
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology*; D001886:Bordetella pertussis / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D014917:Whooping Cough / Q000097:blood* / Q000453:epidemiology* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G