title: Oral vaccination with recombinant Yersinia enterocolitica expressing hybrid type III proteins protects gerbils from amebic liver abscess.
abstract: Protection against invasive amebiasis was achieved in the gerbil model for amebic liver abscess by oral immunization with live attenuated Yersinia enterocolitica expressing the Entamoeba histolytica galactose-inhibitable lectin that has been fused to the Yersinia outer protein E (YopE). Protection was dependent on the presence of the YopE translocation domain but was independent from the antibody response to the ameba lectin.
authors.affiliation: Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany.
authors.forename: Hannelore
authors.initials: H
authors.lastname: Lotter
authors.forename: Holger
authors.initials: H
authors.lastname: Rüssmann
authors.forename: Jürgen
authors.initials: J
authors.lastname: Heesemann
authors.forename: Egbert
authors.initials: E
authors.lastname: Tannich
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D004748:Entamoeba histolytica / Q000276:immunology*; D005849:Gerbillinae; D006801:Humans; D037102:Lectins / Q000276:immunology*; D008101:Liver Abscess, Amebic / Q000517:prevention & control*; D011993:Recombinant Fusion Proteins / Q000276:immunology*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology*; D015008:Yersinia enterocolitica / Q000235:genetics*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D037102:Lectins; D011993:Recombinant Fusion Proteins; D014614:Vaccines, Synthetic; C063239:yopE protein, Yersinia