title: Diagnostic usefulness of bronchoalveolar lavage in Hermansky-Pudlak syndrome: a case with double lung cancers.
abstract: A 65-year-old man was admitted to our hospital because of dyspnea on exertion. He had oculocutaneous albinism innately and his parents were consanguineous. His chest roentgenogram on admission showed reticulo-nodular infiltrates and cystic changes throughout both lung fields, and 7 cm mass in the left middle field. Cytology of bronchoalveolar lavage fluid (BALF) revealed macrophages containing ceroid. The diagnosis of HPS was made clinically and the tumor was diagnosed as poorly differentiated adenocarcinoma of the lung. He died of respiratory failure. By autopsy, additional well-differentiated adenocarcinoma was detected. Cytology of BALF was useful to confirm ceroid accumulation in the lung.
authors.affiliation: Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295.
authors.forename: Kumi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishida
authors.forename: Go
authors.initials: G
authors.lastname: Ogura
authors.forename: Taeko
authors.initials: T
authors.lastname: Ishii
authors.forename: Kengo
authors.initials: K
authors.lastname: Oshima
authors.forename: Suguru
authors.initials: S
authors.lastname: Sato
authors.forename: Miho
authors.initials: M
authors.lastname: Muroi
authors.forename: Kenya
authors.initials: K
authors.lastname: Kanazawa
authors.forename: Junpei
authors.initials: J
authors.lastname: Saito
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Otsuka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Watanabe
authors.forename: Makoto
authors.initials: M
authors.lastname: Handa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Munakata
mesh_terms: D000230:Adenocarcinoma / Q000150:complications; D000368:Aged; D001344:Autopsy; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D002566:Ceroid / Q000032:analysis; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000209:etiology; D017809:Fatal Outcome; D022861:Hermanski-Pudlak Syndrome / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D008175:Lung Neoplasms / Q000150:complications; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D008297:Male; D011859:Radiography
chemical_list: D002566:Ceroid