New macrolides from the sponge Chondrosia corticata.
Three new oxazole-containing metabolites, neohalichondramide (5), (19Z)-halichondramide (6), and secohalichondramide (7), along with four previously reported compounds of the same structural class were isolated from the marine sponge Chondrosia corticata collected from Guam. The structures of novel compounds were determined on the basis of combined spectroscopic analyses. These compounds exhibited significant cytotoxicity and antifungal activity toward the human leukemia cell-line K562 and Candida albicans, respectively.
Shin
Jongheon
J
Natural Products Research Institute, College of Pharmacy, Seoul National University, #28, Yungun, Jongro, Seoul 110-460, Korea. shinj@snu.ac.kr
Lee
Hyi-Seung
HS
Kim
Ji-Yun
JY
Shin
Hee Jae
HJ
Ahn
Jong-Woong
JW
Paul
Valerie J
VJ
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020014:K562 Cells; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
C495172:(19Z)-halichondramide; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D018942:Macrolides; D010080:Oxazoles; C495170:neohalichondramide; C495173:secohalichondramide