title: Ischemic optic neuropathy in dialyzed patients: a previously unrecognized manifestation of calcific uremic arteriolopathy.
abstract: Two patients with end-stage renal disease and on long-term hemodialysis presented with hypotension and an acute unilateral loss of vision. A diagnosis of anterior ischemic optic neuropathy (AION) was made quickly, but despite high-dose steroid therapy, significant vision was not recovered. Temporal artery biopsy results showed extensive medial calcification. The possibility that hypotension, when coupled with calcific uremic arteriolopathy in arteries supplying the optic nerve head, will lead to AION in dialyzed patients is discussed. A short review of AION in the dialysis population is given.
authors.affiliation: Department of Nephrology, Rabin Medical Center (Campus Golda), Petach Tikva, Israel. asherko@clalit.org.il
authors.forename: Asher
authors.initials: A
authors.lastname: Korzets
authors.forename: Idit
authors.initials: I
authors.lastname: Marashek
authors.forename: Ariel
authors.initials: A
authors.lastname: Schwartz
authors.forename: Irit
authors.initials: I
authors.lastname: Rosenblatt
authors.forename: Michal
authors.initials: M
authors.lastname: Herman
authors.forename: Yaacov
authors.initials: Y
authors.lastname: Ori
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000150:complications; D002114:Calcinosis / Q000150:complications*; D005260:Female; D013700:Giant Cell Arteritis / Q000473:pathology*; D006801:Humans; D007022:Hypotension / Q000150:complications; D008297:Male; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis*; D006435:Renal Dialysis / Q000009:adverse effects*; D014511:Uremia / Q000473:pathology / Q000628:therapy