title: AKAP signalling complexes: focal points in space and time.
abstract: Multiprotein signalling networks create focal points of enzyme activity that disseminate the intracellular action of many hormones and neurotransmitters. Accordingly, the spatio-temporal activation of protein kinases and phosphatases is an important factor in controlling where and when phosphorylation events occur. Anchoring proteins provide a molecular framework that orients these enzymes towards selected substrates. A-kinase anchoring proteins (AKAPs) are signal-organizing molecules that compartmentalize various enzymes that are regulated by second messengers.
authors.affiliation: Howard Hughes Medical Institute/Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L-474, Portland, Oregon 97239, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Wong
authors.forename: John D
authors.initials: JD
authors.lastname: Scott
mesh_terms: D054758:A Kinase Anchor Proteins; D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D018797:Cell Cycle Proteins; D000242:Cyclic AMP / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D046911:Macromolecular Substances; D011485:Protein Binding; D020033:Protein Isoforms / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology*; D013997:Time Factors; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D054758:A Kinase Anchor Proteins; C491162:AKAP12 protein, human; D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D046911:Macromolecular Substances; D020033:Protein Isoforms; D011506:Proteins; D018343:Receptors, Adrenergic, beta-2; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D020741:rho GTP-Binding Proteins