Duchenne muscular dystrophy with associated growth hormone deficiency.
A patient with Duchenne muscular dystrophy (DMD) and growth hormone (GH) deficiency is described who had no clinical evidence of muscular weakness before initiation of GH replacement therapy. Treatment with human GH resulted in appearance of symptoms of easy fatigability and proximal muscle weakness. Thorough investigations including serum creatinine phosphokinase (CK) levels is recommended in every patient with GH deficiency before starting GH replacement therapy.
Ghafoor
Tariq
T
Department of Paediatrics, PNS Shifa, Karachi. drghafoortariq@hotmail.com
Mahmood
Arshad
A
Shams
Shahnaz
S
D002648:Child; D019382:Human Growth Hormone / Q000009:adverse effects / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000150:complications*
D019382:Human Growth Hormone