[Immunomodulating activity of polyunsaturated phospholipids and regulators of energy metabolism in toxic anemia].
Possible potentiation of the immunomodulating effects of carbohydrate and lipid metabolism regulators by their use in combination with polyunsaturated phospholipids was studied. The polyunsaturated phospholipids in toxic anemia icreased the immunomodulating effects of thiamine and inosine which activated glucose catabolism in erythrocytes. The combined use of the polyunsaturated phospholipids and thiamine normalized the oxidation--energy status and lowered manifestation of the immunosuppressing properties of light erythrocytes in laboratory rats exposed to hemolytic poison. The use of the combination of the polyunsaturated phospholipids and inosine normalized the oxidation--energy status and induced manifestation of the immunomodulating properties in heavy erythrocytes of the poisoned rats. The globulin fraction of the rat serum containing antibodies to erythrocytes of the poisoned rats exposed to the polyunsaturated phospholipids and inosine increased the immunity status of the poisoned rats treated with the above mentioned agents. Carnitine and biotin in combination with the polyunsatured phospholipids showed no effect on the phagocytic and metabolic activity of leukocytes and the immunity status of the rats exposed to hemolytic poison.
Lazareva
G A
GA
Brovkina
I L
IL
D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D000818:Animals; D000918:Antibody Specificity; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000276:immunology* / Q000378:metabolism; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D007155:Immunologic Factors / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007288:Inosine / Q000008:administration & dosage / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D010743:Phospholipids / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013831:Thiamine / Q000008:administration & dosage / Q000494:pharmacology*
D007136:Immunoglobulins; D007155:Immunologic Factors; D010743:Phospholipids; D007288:Inosine; D013831:Thiamine