[Oxymethyluracil stimulates reparative regeneration of skin in rats].
Oxymethyluracil (OMU) ointment stimulated reparative regeneration of skin in white mongrel rats with model skin damage. The efficacy of this preparation is higher than that of methyluracil-containing ointments (especially of the gel-based preparation). Simultaneous oral administration of OMU potentiated the efficacy of the ointment. After oral administratrion, OMU was found in the wound OMU decreases the level of malonic aldehyde in the blood of rats with model wounds, while not changing the level of nitrogen oxide. In the test group treated with OMU ointment, the biomechanical characteristics of cicatrix after wound healing are closer to the characteristics of intact skin than in the untreated control group.
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D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D004195:Disease Models, Animal; D008297:Male; D009824:Ointments; D051381:Rats; D012867:Skin / Q000293:injuries*; D014498:Uracil / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014945:Wound Healing / Q000187:drug effects*
D000975:Antioxidants; D009824:Ointments; D014498:Uracil; C003029:oxymethacil