Modifications in SENV DNA detection and/or SENV subtype determination over a prospective follow-up in a cohort of HIV-positive patients: is this a moving target?
SEN virus (SENV) is a new family of single-stranded DNA viruses with eight different strains, A-H. The modifications in SENV DNA detection and subtype distribution were studied over a long-term follow-up (48 +/- 32.5 months) in 52 HIV-infected patients. 46% of the patients in the first sample and 34.6% in the second sample were found to have detectable SENV viremia. While the most prevalent variant in the first sample was found to be genotype A (83.3%), the second sample revealed a broader subtype diversification. Several epidemiological and clinical variables were tested in univariate model for clearance of detectable SENV viremia, but none of them reached statistical significance. In conclusion, a high degree of instability of both SENV DNA detection and subtype distribution in a cohort of HIV-infected patients was suggested, which may have important implications for further studies on both SENV epidemiology and its clinical impact.
Quiros-Roldan
Eugenia
E
Institute of Infectious and Tropical Diseases, University of Brescia, Brescia, Italy. kaeniaquiros@hotmail.com
Torti
Carlo
C
Pirovano
Silvia
S
Moretti
Francesca
F
Casari
Salvatore
S
Carosi
Giampiero
G
Soriano
Vicente
V
Imberti
Luisa
L
D000328:Adult; D018136:Circoviridae / Q000235:genetics / Q000302:isolation & purification*; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D011446:Prospective Studies
D004279:DNA, Viral