title: Mechanism of repolarization change during initiation of supraventricular tachycardia.
abstract: BACKGROUND
  Previous literature has documented the association between narrow QRS supraventricular tachycardia (SVT) and pronounced ST-T segment change. The aim of this study was to evaluate repolarization changes during SVT initiation and demonstrate the possible mechanism.
  
  
  RESULTS
  Fifty-one consecutive patients (20 men and 31 women; mean age 46.1 +/- 16.4 years) with narrow QRS SVT (32 patients with AV nodal reentrant tachycardia and 19 patients with AV reentrant tachycardia) were included. We retrospectively analyzed the intracardiac recordings and ST-T segment changes on 12-lead surface ECGs during SVT initiation. Twenty-six (51%) patients developed ST segment repolarization changes during SVT initiation. Patients with shorter baseline sinus cycle length, shorter tachycardia cycle length, elevated systolic blood pressure before tachycardia induction, and greater reduction of systolic blood pressure had a higher incidence of repolarization changes. However, multivariate analysis showed that reduction of systolic blood pressure after SVT induction was the only independent predictor of repolarization changes. Furthermore, the maximal degree of ST segment depression during SVT correlated with the reduction of systolic blood pressure (r = 0.75, P < 0.001).
  
  
  CONCLUSIONS
  Repolarization changes during SVT initiation were caused mainly by concurrent hemodynamic change after SVT initiation with abrupt cycle length shortening.
authors.affiliation: Division of Cardiology, Department of Medicine, National Yang-Ming University, School of Medicine, and Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Yenn-Jiang
authors.initials: YJ
authors.lastname: Lin
authors.forename: Ching-Tai
authors.initials: CT
authors.lastname: Tai
authors.forename: Chen-En
authors.initials: CE
authors.lastname: Chiang
authors.forename: Kun-Tai
authors.initials: KT
authors.lastname: Lee
authors.forename: Yoga
authors.initials: Y
authors.lastname: Yuniadi
authors.forename: Bien-Hsien
authors.initials: BH
authors.lastname: Huang
authors.forename: Tu-Ying
authors.initials: TY
authors.lastname: Liu
authors.forename: Pi-Chiang
authors.initials: PC
authors.lastname: Lee
authors.forename: Jen-Yuan
authors.initials: JY
authors.lastname: Kuo
authors.forename: Shih-Ann
authors.initials: SA
authors.lastname: Chen
mesh_terms: D000328:Adult; D004562:Electrocardiography; D004594:Electrophysiology; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011226:Pre-Excitation Syndromes / Q000503:physiopathology*; D012189:Retrospective Studies; D013617:Tachycardia, Supraventricular / Q000175:diagnosis / Q000503:physiopathology*