title: Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles.
abstract: BACKGROUND
  This study evaluated a possible relationship between levels of endothelial microparticles (EMPs), known to be a sensitive indicator of endothelial disturbance, and changes in postprandial lipid levels in healthy volunteers after a low- or high-fat meal.
  
  
  RESULTS
  Eighteen healthy subjects without known cardiovascular risk factors were evaluated. Lipid and EMP levels were measured before and 1 and 3 hours after a single low- or high-fat isocaloric meal. The low-fat meal had no significant postprandial effect on EMPs or lipids compared with fasting levels. In contrast, a single high-fat meal significantly increased EMP levels after 1 and 3 hours, from 389+/-54 (thousands per milliliter) when fasting to 541+/-139 (P=0.0002) and 677+/-159 (P<0.0001), respectively, and correlated with a postprandial elevation in serum triglycerides.
  
  
  CONCLUSIONS
  A single high-fat meal led to a significant elevation of plasma EMP levels in healthy, normolipidemic subjects and correlated with a postprandial elevation of serum triglycerides. EMPs may be an indirect marker of endothelial dysfunction or injury induced by postprandial triglyceride-rich lipoproteins.
authors.affiliation: University of Miami School of Medicine, Cardiovascular Center, Miami, Fla, USA. aferreir@med.miami.edu
authors.forename: Alexandre C
authors.initials: AC
authors.lastname: Ferreira
authors.forename: Arley A
authors.initials: AA
authors.lastname: Peter
authors.forename: Armando J
authors.initials: AJ
authors.lastname: Mendez
authors.forename: Joaquín J
authors.initials: JJ
authors.lastname: Jimenez
authors.forename: Lucia M
authors.initials: LM
authors.lastname: Mauro
authors.forename: Julio A
authors.initials: JA
authors.lastname: Chirinos
authors.forename: Reyan
authors.initials: R
authors.lastname: Ghany
authors.forename: Salim
authors.initials: S
authors.lastname: Virani
authors.forename: Santiago
authors.initials: S
authors.lastname: Garcia
authors.forename: Lawrence L
authors.initials: LL
authors.lastname: Horstman
authors.forename: Joshua
authors.initials: J
authors.lastname: Purow
authors.forename: Wenche
authors.initials: W
authors.lastname: Jy
authors.forename: Yeon S
authors.initials: YS
authors.lastname: Ahn
authors.forename: Eduardo
authors.initials: E
authors.lastname: de Marchena
mesh_terms: D000328:Adult; D004041:Dietary Fats / Q000008:administration & dosage*; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000473:pathology*; D008297:Male; D010316:Particle Size; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood
chemical_list: D004041:Dietary Fats; D014280:Triglycerides