title: Endoscopic ultrasound-guided fine-needle injection.
abstract: With the development of linear array echoendoscopes and the ability to perform endoscopic ultrasound (EUS)-guided fine-needle aspiration, the delivery of therapeutic agents with fine-needle injection (FNI) emerged. EUS-guided FNI is an attractive delivery system because of its minimal invasiveness and low complication rate. This approach is effective in performing celiac plexus neurolysis for pain relief in patients with pancreatic cancer. The most exciting area of interest involves the delivery of antitumor agents in patients with locally advanced cancer, such as cancer of the pancreas or esophagus. The involvement of EUS-guided FNI in tumor therapy adds a host of potential new applications that continue to swing the pendulum of EUS from a diagnostic to a therapeutic modality.
authors.affiliation: Division of Gastroenterology, University of California Irvine Medical Center, 101 The City Drive, Building 22C, Route 99, Orange, California 92868, USA.
authors.forename: Jason B
authors.initials: JB
authors.lastname: Klapman
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Chang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D001340:Autonomic Nerve Block / Q000295:instrumentation; D001905:Botulinum Toxins / Q000008:administration & dosage; D017115:Catheter Ablation / Q000379:methods; D002447:Celiac Plexus; D002758:Cholangiography / Q000379:methods; D019160:Endosonography / Q000379:methods*; D004931:Esophageal Achalasia / Q000000981:diagnostic imaging / Q000188:drug therapy; D006471:Gastrointestinal Hemorrhage / Q000000981:diagnostic imaging / Q000188:drug therapy; D005770:Gastrointestinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D007267:Injections / Q000379:methods*; D015552:Injections, Intralesional; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D001905:Botulinum Toxins