[Chemically induced Drosophila melanogaster mutants with changes in brain structure].
Neurodegenerative human diseases are caused by nerve cell death and anatomical changes in some brain regions. Molecular genetic studies of Drosophila showed that this organism can serve as a valuable test-system for conserved mechanisms underlying human nervous system disorders. Analysis of brain functions is possible when the mutants with disturbed functions are available. In this study, we have developed a unique collection of Drosophila melanogaster mutants with morphological and neurodegenerative changes in brain structure, which were induced by chemical mutagens.
Shcherbata
G R
GR
Matiĭtsiv
N P
NP
Chernik
Ia I
IaI
Maksimiv
D V
DV
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics*; D005020:Ethyl Methanesulfonate / Q000633:toxicity; D005038:Ethylnitrosourea / Q000633:toxicity; D005260:Female; D017344:Genes, Insect / Q000187:drug effects*; D008297:Male; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D009410:Nerve Degeneration
D009153:Mutagens; D005020:Ethyl Methanesulfonate; D005038:Ethylnitrosourea