Liver disease associated with alpha1-antitrypsin deficiency.
Alpha1-ATD is the most common metabolic liver disease in children for which liver transplantation is performed and, in adults, is associated with cirrhosis, hepatocellular carcinoma, and emphysema. It appears that only a proportion of patients with the deficiency develop clinical manifestations of this disease. Moreover, recent characterization of specific cellular and physiologic events have provided the basis for future potential therapeutic interventions.
Rosen
H R
HR
Division of Gastroenterology and Hepatology, Oregon Health Sciences University, Portland Veterans Affairs Medical Center, Portland, Oregon 97207, USA.
D006801:Humans; D008107:Liver Diseases / Q000209:etiology*; D000515:alpha 1-Antitrypsin / Q000737:chemistry / Q000235:genetics; D019896:alpha 1-Antitrypsin Deficiency / Q000150:complications* / Q000628:therapy
D000515:alpha 1-Antitrypsin