[Expression and its clinical significance of p27 protein in cervical carcinoma tissues].
OBJECTIVE
To investigate the expression of p27 protein and its significance in cervical carcinoma tissues.


METHODS
The p27 protein expression in 26 normal cervical tissues and 48 cervical carcinoma tissues was detected by streptavidin-peroxidase staining(SP method).


RESULTS
The positive rate of p27 protein expression in 48 cervical carcinoma tissues was 39.5%, and that in 26 normal cervical tissues was 72.7%. The former was obviously lower than the latter(P<0.01). In addition, The positive rate of p27 protein in 48 cervical carcinoma tissue was correlated with the differentiation degree of the carcinoma, clinical phase of the patients and lymph node metastasis. In the poorly-differentiated cancer cells, advanced phase patients and the patients with lymph node metastasis, positive rate of p27 protein expression was the lowest.


CONCLUSIONS
The expression of p27 protein is related to differentiation degree of cancer cells, clinical phase of the patients and lymph node metastasis. Detection of p27 protein expression may be valuable to assess prognosis of the patients with cervical carcinoma.
Yu
Yue-cheng
YC
Department of Obstetrics and Gynaecology, Xijing Hospital, Fourth military Medical University, Xi'an 710032, China.
Li
Hong-mei
HM
Xin
Xiao-yan
XY
Zhao
Hai-bo
HB
Li
Qi-ling
QL
Dang
Yan-li
YL
D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000556:secondary; D002584:Cervix Uteri / Q000378:metabolism; D050760:Cyclin-Dependent Kinase Inhibitor p27 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology
D050760:Cyclin-Dependent Kinase Inhibitor p27