Binding properties of the conjugates of oligo(2'-O-methylribonucleotides) with minor groove binders targeted to double stranded DNA.
Design, synthesis, physico-chemical and in vitro biological studies of new pyrimidine oligo(2'-O-methylribonucleotide) conjugates with oligocarboxamide minor groove binders (MGB) and benzoindoloquinoline intercalator (BIQ) are described. These conjugates formed stable triple helices with the target double-stranded DNA and inhibited its in vitro transcription upon binding.
Novopashina
D S
DS
Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia. danov@niboch.nsc.ru
Sinyakov
A N
AN
Ryabinin
V A
VA
Venyaminova
A G
AG
Perrouault
L
L
Brunet
E
E
Giovannangeli
C
C
Boutorine
A S
AS
D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D012265:Ribonucleotides / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
D012265:Ribonucleotides; D004247:DNA