title: Spontaneous epithelial plaques in the uterus of a non-pregnant cynomolgus monkey (Macaca fascicularis).
abstract: Two epithelial plaques were observed in the uterus of a 4 years 8 month old non-pregnant cynomolgus monkey. Normally, epithelial plaques occur near the implantation site of primates during early pregnancy but can also be induced by various procedures. Both plaques consisted of clusters and nest of cells with large nuclei and a faintly basophilic cytoplasm. Marked cellular pleomorphism was seen, including cells with giant nuclei and binucleated cells. Further histological features were vacuolation, mitosis and PAS-positive granules in several cells and polymorphonuclear infiltration in the periphery of the plaque. This is the second description of a spontaneous epithelial plaque in a primate and the first in a cynomolgus monkey.
authors.affiliation: Department of Pathology, Covance Laboratories, Kesselfeld 29, D-48163 Münster, Germany. joachim.kaspareit@covance.com
authors.forename: J
authors.initials: J
authors.lastname: Kaspareit
authors.forename: S
authors.initials: S
authors.lastname: Friderichs-Gromoll
authors.forename: E
authors.initials: E
authors.lastname: Buse
authors.forename: G
authors.initials: G
authors.lastname: Habermann
authors.forename: F
authors.initials: F
authors.lastname: Vogel
mesh_terms: D000818:Animals; D004848:Epithelium / Q000473:pathology; D005260:Female; D008252:Macaca fascicularis; D014599:Uterus / Q000473:pathology*