Evidence of QTLs on chromosomes 1q42 and 8q24 for LDL-cholesterol and apoB levels in the HERITAGE family study.
Genome-wide multipoint linkage analyses were performed to identify chromosomal regions harboring genes influencing LDL-cholesterol, total apolipoprotein B (apoB), and LDL-apoB levels using 654 markers. They were assessed in a sedentary state (baseline) and after a 20 week endurance training program. Strong evidence for two quantitative trait loci (QTLs) for baseline levels was found. There is linkage evidence in black families on chromosomes 1q41-q44 [at marker D1S2860, 238 centimorgan (cM), with a maximum log of the odds (LOD) score of 3.7 for LDL-apoB] and in white families on chromosome 8q24 (at marker D8S1774, 142 cM, with LOD scores of 3.6, 3.3, and 2.5 for baseline LDL-cholesterol, LDL-apoB, and apoB, respectively). There were no strong signals for the lipoprotein training responses (as computed as the difference in posttraining minus baseline levels). In conclusion, QTLs for baseline apoB and LDL-cholesterol levels on chromosomes 1q41-q44 (in blacks) and 8q24 (in whites) were found. As there are no known strong candidate genes in these regions for lipids, follow-up studies to determine the source of those signals are needed.
Feitosa
Mary F
MF
Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, USA. maryf@wubios.wustl.edu
Borecki
Ingrid B
IB
Rankinen
Tuomo
T
Rice
Treva
T
Després
Jean-Pierre
JP
Chagnon
Yvon C
YC
Gagnon
Jacques
J
Leon
Arthur S
AS
Skinner
James S
JS
Bouchard
Claude
C
Province
Michael A
MA
Rao
D C
DC
D001055:Apolipoproteins B / Q000097:blood* / Q000378:metabolism; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood* / Q000378:metabolism; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002898:Chromosomes, Human, Pair 8; D004492:Edetic Acid / Q000737:chemistry; D015444:Exercise; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D016678:Genome; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D010641:Phenotype; D040641:Quantitative Trait Loci; D013997:Time Factors
D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D005819:Genetic Markers; D007328:Insulin; D008074:Lipoproteins; D004492:Edetic Acid