title: Two new cytotoxic tetracyclic tetraterpenoids from the soft coral Sarcophyton tortuosum.
abstract: Two new cytotoxic tetracyclic tetraterpenoids, methyl tortuoate A (1) and methyl tortuoate B (2), along with the known methyl sartortuoate (3) were isolated from the soft coral Sarcophyton tortuosum. The structures of 1 and 2 were established by spectroscopic methods, mainly on the basis of 2D NMR techniques, and were confirmed by single-crystal X-ray diffraction analysis. The cytotoxic activities of these compounds were carried out in vitro on human nasophyringeal carcinoma (CNE-2) and murine lymphocytic leukemia (P-388) tumor cell lines.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, People's Republic of China 510275. ceszlm@zsu.edu.cn
authors.forename: Long-Mei
authors.initials: LM
authors.lastname: Zeng
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Lan
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Su
authors.forename: Guang-Wen
authors.initials: GW
authors.lastname: Zhang
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Feng
authors.forename: Yong-Ju
authors.initials: YJ
authors.lastname: Liang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Yang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes; C000607798:methyl sartortuoate; C495050:methyl tortuoate A; C495051:methyl tortuoate B