Clostridium-mediated transfer system of therapeutic proteins to solid tumors: increased heterologous protein production.
Barbé
Sofie
S
Laboratorium Bacteriologie, Rega Instituut, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Van Mellaert
Lieve
L
Anné
Jozef
J
D001421:Bacteria, Anaerobic / Q000502:physiology; D001483:Base Sequence; D015687:Cell Hypoxia; D046969:Clostridium acetobutylicum / Q000502:physiology*; D017931:DNA Primers; D004337:Drug Carriers; D005822:Genetic Vectors; D006801:Humans; D016297:Mutagenesis, Site-Directed; D009336:Necrosis; D009369:Neoplasms / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic; D011994:Recombinant Proteins / Q000378:metabolism; D013171:Spores, Bacterial; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage* / Q000235:genetics / Q000627:therapeutic use
D017931:DNA Primers; D004337:Drug Carriers; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha