Comparative toxicity study of 2,4,6-trinitrophenol (picric acid) in newborn and young rats.
The toxicity of oral 2,4,6-trinitrophenol (TNP) was determined in newborn rats, and compared with that in young rats. In newborn rats, males and females were given TNP at 0, 16.3, 81.4 or 407 mg/kg per day on postnatal days (PND) 4-17 for the dose-finding study, and at 0, 4.1, 16.3 or 65.1 mg/kg per day on PND 4-21 for the main study. Deaths, lower body weight (BW) and behavioral changes were found at 81.4 and 407 mg/kg per day in the dose-finding study, and lower BW was observed in males at 65.1 mg/kg per day during the dosing period of the main study. In young rats, 5-week-old males and females were given TNP at 0, 20, 100 or 500 mg/kg per day for 14 days as the dose-finding study and at 0, 4, 20 or 100 mg/kg per day for 28 days as the main study. Deaths were observed at 500 mg/kg per day in the dose-finding study. Deaths or changes in BW were not found at 100 mg/kg per day or less. At 100 mg/kg per day, hemolytic anemia and testicular toxicity were found. In conclusion, toxicity profiles induced by TNP were markedly different between newborn and young rats.
Takahashi
Mika
M
National Institute of Health Sciences, Tokyo 158-8501, Japan.
Ogata
Hidehiro
H
Izumi
Hiroyuki
H
Yamashita
Kotaro
K
Takechi
Masato
M
Hirata-Koizumi
Mutsuko
M
Kamata
Eiichi
E
Hasegawa
Ryuichi
R
Ema
Makoto
M
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010851:Picrates / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D013737:Testis / Q000187:drug effects
D010851:Picrates; C005858:picric acid