title: [Radiation-induced rat cerebral neuron apoptosis].
abstract: OBJECTIVE
  To explore the correlation between X-ray-induced rat cerebral neuron apoptosis and radiation doses.
  
  
  METHODS
  In a controlled experiment, the rats in the experimental group received X-ray radiation at different doses (2, 4, 6 and 8 Gy), and the apoptotic cerebral neurons were counted after in situ end-labeling and immunohistochemical staining.
  
  
  RESULTS
  X-ray radiation induced apoptosis of rat cerebral neurons, and the apoptotic rate varied with the radiation doses. Significant difference in the apoptotic rate was noted before and after radiation (P<0.0001), and between different radiation dose groups (P<0.005). The apoptotic rate differed significantly at different time points after the radiation.
  
  
  CONCLUSIONS
  Low or medium doses of X-ray is able to induce rat cerebral neuron apoptosis depending on the radiation doses and following a definable time course.
authors.affiliation: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. fengwf@fimmu.com
authors.forename: Wen-feng
authors.initials: WF
authors.lastname: Feng
authors.forename: Song-tao
authors.initials: ST
authors.lastname: Qi
authors.forename: Bing-hui
authors.initials: BH
authors.lastname: Qiu
authors.forename: Kai-jun
authors.initials: KJ
authors.lastname: Yang
authors.forename: Li-jing
authors.initials: LJ
authors.lastname: Huang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D002540:Cerebral Cortex / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D009474:Neurons / Q000473:pathology / Q000528:radiation effects*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors