title: In vitro antioxidant studies of Annona squamosa Linn. leaves.
abstract: The free radical scavenging potential of the leaves of A. squamosa was studied by using different antioxidant models of screening. The ethanolic extract at 1000 microg/ml showed maximum scavenging of the radical cation, 2,2-azinobis- (3-ethylbenzothiazoline-6-sulphonate) (ABTS) observed upto 99.07% followed by the scavenging of the stable radical 1,1-diphenyl, 2-picryl hydrazyl (DPPH) (89.77 %) and nitric oxide radical (73.64%) at the same concentration. However, the extract showed only moderate scavenging activity of superroxide radicals and antilipid peroxidation potential, which was performed using rat- brain homogenate. The findings justify the therapeutic applications of the plant in the indigenous system of medicine, augmenting its therapeutic value.
authors.affiliation: Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576 104, India. annieshirwaikar@yahoo.com
authors.forename: Annie
authors.initials: A
authors.lastname: Shirwaikar
authors.forename: K
authors.initials: K
authors.lastname: Rajendran
authors.forename: C Dinesh
authors.initials: CD
authors.lastname: Kumar
mesh_terms: D000818:Animals; D031041:Annona; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D010936:Plant Extracts