title: In vitro antibacterial activity of echinomycin and a novel analogue, YK2000, against vancomycin-resistant enterococci.
abstract: The in vitro inhibitory and bactericidal activity of echinomycin and its the novel synthetic analogues of echinomycin,YK2000 and YK2005, were evaluated using 93 clinical isolates of vancomycin-resistant enterococci (VRE). In agar dilution tests, the MIC(90) of echinomycin and YK2000 were 0.125 and 8 mg/l, respectively, using Mueller-Hinton II agar, while that of YK2005 was 32 mg/l. Bactericidal activity of echinomycin and YK2000 were two to four times higher than the MIC in time-kill assay experiments. These results suggest that echinomycin and its analogues might be useful as anti-VRE drugs.
authors.affiliation: Department of Biomedical Laboratory Science, College of Health Sciences, South Korea. kimjb@dragon.yonsei.ac.kr
authors.forename: Jong-Bae
authors.initials: JB
authors.lastname: Kim
authors.forename: Gyu-Sang
authors.initials: GS
authors.lastname: Lee
authors.forename: Yun-Bong
authors.initials: YB
authors.lastname: Kim
authors.forename: Soo-Kie
authors.initials: SK
authors.lastname: Kim
authors.forename: Yong Hae
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004448:Echinomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016984:Enterococcus faecium / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D014640:Vancomycin / Q000494:pharmacology; D020713:Vancomycin Resistance / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; C498839:YK2000; D004448:Echinomycin; D014640:Vancomycin