Thirst changes in offspring of hyperreninemic rat dams.
The aim of this study was to investigate the changes in thirst dependence on the renin-angiotensin system (RAS), in offspring of hyperreninemic, hyperdipsic, and natriophilic rat dams. Female rats underwent a partial aortic ligature between the renal arteries (PAL) or were sham-operated (SHAM). At 6 days of age, offspring of PAL (O-PAL) and SHAM (O-SHAM) dams were injected with isoproterenol (subcutaneously, 500 microg/kg body weight) or vehicle. Pretreatment with captopril (intraperitoneally, 50 mg/kg) on isoproterenol-induced thirst was also studied. Plasma renin activity in dams and hematocrit and osmolality in pups were measured. O-PAL had a greater water intake than O-SHAM. However, they responded similarly to isoproterenol or isoproterenol with captopril pretreatment. Only minor differences in hematocrit and osmolality were found between O-SHAM and O-PAL rats after isoproterenol or vehicle treatment. Beta-adrenergic or angiotensinergic responsivity seems not to be altered in offspring of hyperrenimic, hyperdipsic, and natriophilic dams. Nevertheless, other thirst responses of offspring may be critically dependent upon uterine conditions.
Perillan
C
C
Area de Fisiología, Departamento de Biología Funcional, Facultad de Medicina, Universidad de Oviedo, c/Julián Clavería s/n 33006 Oviedo, Spain.
Costales
M
M
Diaz
F
F
Vijande
M
M
Arguelles
J
J
D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000502:physiology; D002216:Captopril / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D008026:Ligation / Q000379:methods; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood; D013894:Thirst / Q000187:drug effects / Q000502:physiology*
D002216:Captopril; D012083:Renin; D007545:Isoproterenol