Undetectable plasma HIV-1 RNA with strong gag-pol specific interferon-gamma ELISPOT response in an HIV-1 clade A/E-infected child untreated with antiretroviral therapy.
We report a 7-year HIV-1 clade A/E-infected child untreated with antiretroviral therapy who had positive HIV antibody testing but undetectable plasma HIV-1 RNA by Roche Amplicor version 1.5 and bDNA version 3.0. DNA PCR was positive by methods using gag/pol primers but not env/pol primers. The patient had strong HIV-1-specific cytotoxic T lymphocyte responses, which likely contributed to her low viral burden and undetectable plasma HIV-1 RNA.
Ananworanich
Jintanat
J
The HIV Netherlands Australia Thailand Research Collaboration and the Thai Red Cross AIDS Research Center, Thailand.
Pancharoen
Chitsanu
C
Sirivichayakul
Sunee
S
Buranapraditkun
Supranee
S
Apateerapong
Wichitra
W
Ubolyam
Sasiwimol
S
Ruxrungtham
Kiat
K
D044966:Anti-Retroviral Agents; D015153:Blotting, Western; D002648:Child; D017931:DNA Primers; D004279:DNA, Viral / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015685:Fusion Proteins, gag-pol / Q000097:blood / Q000235:genetics*; D015658:HIV Infections / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D015497:HIV-1 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007371:Interferon-gamma / Q000097:blood / Q000276:immunology; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000097:blood*; D019562:Viral Load
D044966:Anti-Retroviral Agents; D017931:DNA Primers; D004279:DNA, Viral; D015685:Fusion Proteins, gag-pol; D012367:RNA, Viral; D007371:Interferon-gamma