Reelin glycoprotein: structure, biology and roles in health and disease.
Reelin glycoprotein is a secretory serine protease with dual roles in mammalian brain: embryologically, it guides neurons and radial glial cells to their corrected positions in the developing brain; in adult brain, Reelin is involved in a signaling pathway which underlies neurotransmission, memory formation and synaptic plasticity. Disruption of Reelin signaling pathway by mutations and selective hypermethylation of the Reln gene promoter or following various pre- or postnatal insults may lead to cognitive deficits present in neuropsychiatric disorders like autism or schizophrenia.
Fatemi
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Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, 420 Delaware Street, Minneapolis, MN 55455, USA. fatem002@umn.edu
D000818:Animals; D001321:Autistic Disorder / Q000503:physiopathology*; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D006801:Humans; D051379:Mice; D008818:Mice, Neurologic Mutants; D009419:Nerve Tissue Proteins / Q000502:physiology*; D000091042:Reelin Protein; D012559:Schizophrenia / Q000503:physiopathology*; D012697:Serine Endopeptidases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717127:RELN protein, human; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases