title: [BMP and bone formation].
abstract: Bone Morphogenetic Proteins (BMPs) are secreted proteins that represent a group of the transforming growth factor-beta. BMPs were identified as molecules that induce ectopic bone formation in muscles of mice. The homo- or heterodimetric BMP proteins, which bind to serine/threonine protein-kinase receptor and activate smad and p38MAPK signal transductions, function as potent osteogenic factors. In vivo, it is not clear which BMPs play crucial roles in regulating osteogenesis. Clinical uses of rhBMP-2 and rhBMP-7 have been performed, but we need numerous rhBMPs, which is very expensive, to induce osteogenesis in humans.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Kugimiya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Ung-Il
authors.initials: UI
authors.lastname: Chung
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D010012:Osteogenesis / Q000187:drug effects
chemical_list: D019485:Bone Morphogenetic Proteins