title: The Paris-Sud yeast structural genomics pilot-project: from structure to function.
abstract: We present here the outlines and results from our yeast structural genomics (YSG) pilot-project. A lab-scale platform for the systematic production and structure determination is presented. In order to validate this approach, 250 non-membrane proteins of unknown structure were targeted. Strategies and final statistics are evaluated. We finally discuss the opportunity of structural genomics programs to contribute to functional biochemical annotation.
authors.affiliation: Institut de Biochimie et de Biophysique Moléculaire et Cellulaire (CNRS-UMR 8619), Université Paris-Sud, Bâtiment 430, 91405 Orsay, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Quevillon-Cheruel
authors.forename: Dominique
authors.initials: D
authors.lastname: Liger
authors.forename: Nicolas
authors.initials: N
authors.lastname: Leulliot
authors.forename: Marc
authors.initials: M
authors.lastname: Graille
authors.forename: Anne
authors.initials: A
authors.lastname: Poupon
authors.forename: Inès
authors.initials: I
authors.lastname: Li de La Sierra-Gallay
authors.forename: Cong-Zhao
authors.initials: CZ
authors.lastname: Zhou
authors.forename: Bruno
authors.initials: B
authors.lastname: Collinet
authors.forename: Joël
authors.initials: J
authors.lastname: Janin
authors.forename: Herman
authors.initials: H
authors.lastname: Van Tilbeurgh
mesh_terms: D023281:Genomics; D011487:Protein Conformation; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry
chemical_list: D029701:Saccharomyces cerevisiae Proteins