title: Disseminated cutaneous leishmaniasis due to Leishmania guyanensis: case of a patient with 425 lesions.
abstract: Disseminated cutaneous leishmaniasis is characterized by the presence of a large (> or =10) number of lesions at several anatomic sites (head, limbs, and trunk). Most of the lesions are small, papular, and appear simultaneously with or secondarily to one or several ulcerated lesions of localized cutaneous leishmaniasis. We report the first case of disseminated cutaneous leishmaniasis in French Guiana. It concerns a 24-year-old woman who tested negative for human immunodeficiency virus (HIV). The disease began with three lesions that became ulcerated. One week later, multiple papulo-nodular lesions appeared. We counted a total of 425 lesions. Leishmania were observed in the lesions. The species involved was L. guyanensis, which has never been described in a case of disseminated cutaneous leishmaniasis. The patient was rapidly cured by a single course of pentamidine. Disseminated cutaneous leishmaniasis should be distinguished from other types of leishmaniasis with multiple lesions. These include anergic diffuse cutaneous leishmaniasis, post-kala-azar leishmaniasis, and leishmaniasis associated with HIV infection.
authors.affiliation: Institut Guyanais de Dermatologie Tropicale, Service de Dermatologie et Service Hospitalo-Universitaire de Parasitologie-Mycologie, Centre Hospitalier de Cayenne, Cayenne, French Guiana.
authors.forename: P
authors.initials: P
authors.lastname: Couppié
authors.forename: E
authors.initials: E
authors.lastname: Clyti
authors.forename: D
authors.initials: D
authors.lastname: Sainte-Marie
authors.forename: J P
authors.initials: JP
authors.lastname: Dedet
authors.forename: B
authors.initials: B
authors.lastname: Carme
authors.forename: R
authors.initials: R
authors.lastname: Pradinaud
mesh_terms: D000328:Adult; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001415:Back; D001940:Breast; D003937:Diagnosis, Differential; D005260:Female; D005385:Fingers; D005616:French Guiana; D006801:Humans; D018334:Leishmania guyanensis; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D010419:Pentamidine / Q000627:therapeutic use
chemical_list: D000981:Antiprotozoal Agents; D010419:Pentamidine