title: Hippocampal atrophy, whole brain volume, and white matter lesions in older hypertensive subjects.
abstract: OBJECTIVE
  To determine the potential role of whole brain atrophy, hippocampal atrophy, or both, and small vessel disease/white matter lesions as mechanisms underlying the cognitive impairment associated with hypertension.
  
  
  METHODS
  Using MRI scanning the authors determined hippocampal volumes, whole brain volumes, and location and severity of white matter lesions, using Scheltens scale, in 103 hypertensive (166 +/- 8/88 +/- 7 mm Hg, 54 female) and 51 normotensive (132 +/- 12/74 +/- 7 mm Hg, 21 female) subjects age > or = 70 years.
  
  
  RESULTS
  Compared to normotensive subjects, older hypertensive subjects had significantly smaller whole brain volumes (887 +/- 109 vs 930 +/- 97 cm3, p = 0.02) and nonsignificantly reduced hippocampal volumes (5.39 +/- 1.60 vs 5.67 +/- 1.80 cm3, p = 0.33). Hypertensive subjects had an increased burden of periventricular lesions: bands (p = 0.03), frontal caps (p = 0.08), occipital caps (p = 0.07), and total periventricular hyperintensities (p = 0.02). They also had higher scores in subcortical areas: frontal (p = 0.04), temporal (p = 0.03), and deep white matter areas (p = 0.05). A correlation was found between whole brain volumes and systolic blood pressure (r = -0.19, p = 0.02). No correlation was seen between whole brain volumes and white matter lesion burden.
  
  
  CONCLUSIONS
  Moderate hypertension in non-impaired older subjects is associated with smaller whole brain volume and an increased burden of subcortical and periventricular white matter lesions.
authors.affiliation: Institute for Aging and Health, University of Newcastle upon Tyne, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Wiseman
authors.forename: B K
authors.initials: BK
authors.lastname: Saxby
authors.forename: E J
authors.initials: EJ
authors.lastname: Burton
authors.forename: R
authors.initials: R
authors.lastname: Barber
authors.forename: G A
authors.initials: GA
authors.lastname: Ford
authors.forename: J T
authors.initials: JT
authors.lastname: O'Brien
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use; D001284:Atrophy; D001794:Blood Pressure; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000473:pathology / Q000523:psychology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009186:Myelin Sheath / Q000473:pathology*; D009929:Organ Size / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents