Identification of potential antibody markers in HIV-associated dementia.
Markers for HIV-associated dementia (HAD) are needed for diagnosis and management. Specific antibodies to brain and immune complexes (IC) in the cerebrospinal fluid (CSF) are potential markers. CSF IC were found in 4 of 4 HAD patients, 2 of 2 AIDS-central nervous system (CNS) lymphoma patients with dementia, 0 of 1 AIDS-CNS lymphoma patient without dementia, 0 of 1 AIDS-CNS toxoplasmosis patient without dementia, and 0 of 10 neurologic disease controls. By blinded immunoblots, antibrain antibodies in serum and CSF were found in 11 of 12 HAD cases and 7 of 19 HIV-1 patients without HAD. All 11 non-HIV-1 controls were negative. These and published data suggest antibrain antibodies and IC may serve as markers of HAD.
Schutzer
Steven E
SE
Department of Medicine, UMDNJ-New Jersey Medical School, 185 South Orange Ave., Newark, NJ 07103, USA. schutzer@umdnj.edu
Berger
Joseph R
JR
Brunner
Michael
M
D015526:AIDS Dementia Complex / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000276:immunology*; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D015153:Blotting, Western / Q000379:methods; D001921:Brain / Q000276:immunology / Q000378:metabolism / Q000821:virology; D015483:HIV Antibodies / Q000378:metabolism*; D006801:Humans
D015415:Biomarkers; D015483:HIV Antibodies