title: [Quantitative study of brain perfusion patterns of 99mTc-ECD SPECT in children with developmental disabilities].
abstract: The aim of this study was to investigate the relationship between developmental disabilities and brain perfusion patterns. We performed technetium-99 m-ethylcysteinate dimer (99m-Tc-ECD) single photon emission computed tomography (SPECT) in 30 children with neurological disorders using the Patlak plot method. In children without developmental disabilities, the distribution of regional cortical perfusion evolved in relation to brain maturation. At one month of age, there was a predominant uptake in the perirolandic cortex. Radionuclide uptake in both the parietal and occipital cortices became evident by three months. Uptake in the temporal and frontal cortex increased by 6 and 11 months, respectively. Brain perfusion showed a pattern similar to that of adults by two years of age at the latest. In children with developmental disabilities, developmental changes of brain perfusion were delayed compared to normally developing children. Brain SPECT is a useful tool to assess the brain maturation in children with developmental disabilities.
authors.affiliation: Department of Pediatric Neurology, Shizuoka Children's Hospital, Shizuoka. kooya@mb.infoweb.ne.jp
authors.forename: Keiko
authors.initials: K
authors.lastname: Hirano
authors.forename: Hideo
authors.initials: H
authors.lastname: Aiba
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Oguro
mesh_terms: D000293:Adolescent; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D003545:Cysteine / Q000031:analogs & derivatives*; D002658:Developmental Disabilities / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine