title: Craniofacial hyperostoses in Proteus syndrome -- a case report.
abstract: OBJECTIVE
  Description of a patient with a rare syndrome leading to the partial overgrowth of craniofacial bones.
  
  
  METHODS
  In a 17-year-old female patient with severe hyperostoses of the craniofacial bones asymmetric overgrowth of the right upper and left lower limbs, linear hyperpigmentation of the right arm and a history of regional lipomatosis were found. These manifestations were suggestive of Proteus syndrome. The management of the craniofacial involvement is described and a literature overview presented.
  
  
  CONCLUSIONS
  Proteus syndrome is a rare overgrowth syndrome probably related to a somatic mutation that involves craniofacial structures in about 30% of patients. Early diagnosis is required for adequate interdisciplinary treatment.
authors.affiliation: Department for Oral and Maxillofacial Surgery, Surgical Robotics and Navigation, University of Charité, Campus Virchow-Klinikum, Medizinische Fakultät der Humboldt-Universität, Berlin, Germany. n_adolphs@hotmail.com
authors.forename: Nicolai
authors.initials: N
authors.lastname: Adolphs
authors.forename: Sigrid
authors.initials: S
authors.lastname: Tinschert
authors.forename: Jürgen
authors.initials: J
authors.lastname: Bier
authors.forename: Martin
authors.initials: M
authors.lastname: Klein
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005147:Facial Bones / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015576:Hyperostosis / Q000473:pathology*; D017495:Hyperpigmentation / Q000473:pathology; D008068:Lipomatosis / Q000473:pathology; D016715:Proteus Syndrome / Q000473:pathology*