Relapsing polychondritis in HIV-infected patients: a report of two cases.
Relapsing polychondritis is a rare autoimmune disease characterized by inflammation and degeneration of cartilaginous tissue. We describe the first reported cases of relapsing polychondritis in patients with human immunodeficiency virus (HIV) and no associated connective tissue diseases. The relationship between autoimmune and HIV diseases is complex and unclear. Treatment of HIV disease with antiretroviral therapy and subsequent immune restoration may lead to the development of autoimmune diseases in genetically susceptible individuals.
Dolev
Jacqueline C
JC
Department of Dermatology, University of California, San Francisco, San Francisco, California 94110, USA.
Maurer
Toby A
TA
Reddy
Suraj G
SG
Ramirez
Lori E
LE
Berger
Timothy
T
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003622:Dapsone / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D011081:Polychondritis, Relapsing / Q000188:drug therapy / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D003622:Dapsone; D011241:Prednisone