title: Two tonB systems function in iron transport in Vibrio anguillarum, but only one is essential for virulence.
abstract: We have identified two functional tonB systems in the marine fish pathogen Vibrio anguillarum, tonB1 and tonB2. Each of the tonB genes is transcribed in an operon with the cognate exbB and exbD genes in response to iron limitation. Only tonB2 is essential for transport of ferric anguibactin and virulence.
authors.affiliation: Department of Molecular Microbiology and Immunology, Oregon Health & Science University, SW Sam Jackson Park Road, Portland, OR 97239, USA.
authors.forename: Michiel
authors.initials: M
authors.lastname: Stork
authors.forename: Manuela
authors.initials: M
authors.lastname: Di Lorenzo
authors.forename: Susana
authors.initials: S
authors.lastname: Mouriño
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Osorio
authors.forename: Manuel L
authors.initials: ML
authors.lastname: Lemos
authors.forename: Jorge H
authors.initials: JH
authors.lastname: Crosa
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D001692:Biological Transport; D015964:Gene Expression Regulation, Bacterial; D007501:Iron / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D010455:Peptides / Q000378:metabolism; D014733:Vibrio / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; D010455:Peptides; C057616:tonB protein, Bacteria; C049469:anguibactin; D007501:Iron