[A case of advanced colon cancer responding completely to systemic 5-fluorouracil/l-leucovorin therapy].
A 79-year-old man was admitted for advanced transverse colon cancer with large bowel obstruction. Twelve years earlier he underwent a total gastrectomy with Roux-en Y reconstruction for gastric cancer. No metastasis was detected preoperatively. Exploratory laparotomy revealed massive direct invasion of the mesenterium of the jejunum for Roux-en Y reconstruction. The primary lesion was unresected and transverse colostomy was made. Systemic chemotherapy with 5-fluorouracil and l-leucovorin was scheduled for a total of 4 courses postoperatively. After completion of this chemotherapeutic regimen, a CT scan and colonofiberscopy revealed the primary lesions had disappeared, and a histological examination of biopsy confirmed that the patient had achieved a complete remission (CR). There was no severe side effect during chemotherapy. The patient is presently enjoying a good general condition and has been free from any sign of recurrence.
Mizushima
Tsunekazu
T
Dept. of Surgery, Rinku General Medical Center, Izumisano Municipal Hospital.
Sando
Kinya
K
Ito
Toshikazu
T
Mikata
Shoki
S
Nonaka
Kentaro
K
Ide
Haruki
H
Michiura
Toshiya
T
Kainuma
Satoshi
S
Yamanaka
Hiroaki
H
Iwase
Kazuhiro
K
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003125:Colostomy; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D009361:Neoplasm Invasiveness
D002955:Leucovorin; D005472:Fluorouracil