title: [Relationship between serum leptin and tumor necrosis factor and endothelin in patients with chronic renal failure].
abstract: OBJECTIVE
  To assess the serum level of leptin and its relationship between tumor necrosis factor, and endothelin in patients with chronic renal failure.
  
  
  METHODS
  Serum level of leptin,tumor necrosis factor and endothelin were measured in 40 patients with chronic renal failure and 20 healthy controls by radioimmunoassay. Correlation analysis was performed between serum level of leptin and tumor necrosis factor and endothelin.
  
  
  RESULTS
  Serum leptin in patients with chronic renal failure was significantly higher than that in healthy control subjects((19.25+/-4.89)microg/L vs. (5.57+/-1.69)microg/L, P<0.01). There was significant positive correlation between serum leptin and tumor necrosis factor and endothelin (r(TNF)=0.829, r(ET)=0.605; both P<0.01).
  
  
  CONCLUSIONS
  The abnormal increased serum levels of tumor necrosis factor and endothelin are associated with hyperleptinemia in patients with chronic renal failure.
authors.affiliation: Department of Nephrology, Yijishan Hospital Affiliated to Wannan Medical College, Wuhu 241001, Anhui, China.
authors.forename: Dao-you
authors.initials: DY
authors.lastname: Zhang
authors.forename: Li-cai
authors.initials: LC
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Xin-lu
authors.initials: XL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D048069:Tumor Necrosis Factors / Q000097:blood*
chemical_list: D016232:Endothelins; D020738:Leptin; D048069:Tumor Necrosis Factors