[Regulation of bone mineralization by enzymes].
The enzymes, such as TNSALP regulate bone mineralization, and the mineralization inhibitor inorganic pyrophosphate (PPi) plays a central role in the process. NPP1 and ANK increase PPi concentration in the extracellular matrix, while TNSALP hydrolyzes PPi. The analyses using knock-out mice demonstrated that NPP1 and ANK, and TNSALP are antagonistic regulators for PPi. Concerted regulation of PPi by TNSALP, NPP1, and ANK, leads bone mineralization to be regulated strictly.
Kubota
Takuo
T
Department of Developmental Medicine, Osaka University Graduate School of Medicine.
Ozono
Keiichi
K
D000469:Alkaline Phosphatase / Q000502:physiology*; D000818:Animals; D002113:Calcification, Physiologic / Q000502:physiology*; D003541:Cystathionine beta-Synthase / Q000502:physiology; D011756:Diphosphates / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000502:physiology; D051379:Mice; D053402:PHEX Phosphate Regulating Neutral Endopeptidase; D028061:Phosphate Transport Proteins; D010727:Phosphoric Diester Hydrolases / Q000502:physiology*; D011506:Proteins / Q000502:physiology; D011755:Pyrophosphatases / Q000502:physiology*
C498770:ANKH protein, human; D011756:Diphosphates; D008565:Membrane Proteins; D028061:Phosphate Transport Proteins; D011506:Proteins; C410982:ank protein, mouse; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D000469:Alkaline Phosphatase; D010727:Phosphoric Diester Hydrolases; D053402:PHEX Phosphate Regulating Neutral Endopeptidase; C506231:PHEX protein, human; C506232:Phex protein, mouse; D011755:Pyrophosphatases; C405782:nucleotide pyrophosphatase - phosphodiesterase I; D003541:Cystathionine beta-Synthase