title: alpha-Cycloalkyl-substituted omega-keto-dicarboxylic acids as lipid regulating agents.
abstract: A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC(50) activity in the 0.3-1.0 microM range on the de novo incorporation of radiolabeled acetate into lipids in primary cultures of rat hepatocytes, and they showed lipid-regulating properties when tested in vivo in female obese Zucker fatty rats.
authors.affiliation: MercaChem BV, Toernooiveld 100, 6525 EC Nijmegen, The Netherlands.
authors.forename: Roel P L
authors.initials: RP
authors.lastname: Bell
authors.forename: Dennis
authors.initials: D
authors.lastname: Verdijk
authors.forename: Mike
authors.initials: M
authors.lastname: Relou
authors.forename: Dennis
authors.initials: D
authors.lastname: Smith
authors.forename: Henk
authors.initials: H
authors.lastname: Regeling
authors.forename: Eelco J
authors.initials: EJ
authors.lastname: Ebbers
authors.forename: Frank M C
authors.initials: FM
authors.lastname: Leemhuis
authors.forename: Daniela C
authors.initials: DC
authors.lastname: Oniciu
authors.forename: Clay T
authors.initials: CT
authors.lastname: Cramer
authors.forename: Brian
authors.initials: B
authors.lastname: Goetz
authors.forename: Michael E
authors.initials: ME
authors.lastname: Pape
authors.forename: Brian R
authors.initials: BR
authors.lastname: Krause
authors.forename: Charles L
authors.initials: CL
authors.lastname: Bisgaier
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Dasseux
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003998:Dicarboxylic Acids / Q000737:chemistry / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003998:Dicarboxylic Acids; D008055:Lipids; D008074:Lipoproteins