title: Effects of hormone replacement therapy or raloxifene on ambulatory blood pressure and arterial stiffness in treated hypertensive postmenopausal women.
abstract: The administration of oral raloxifene in 30 postmenopausal hypertensive women was evaluated to demonstrate its effect on arterial stiffness. Casual and ambulatory blood pressure (BP) and pulse-wave velocity (PWV) data were obtained before and after patients received raloxifene, estrogen-progestin replacement therapy, or placebo in a randomized crossover study. It was shown that the 2 therapies decreased BP and carotid-femoral PWV, and the effect of raloxifene on vascular compliance was independent of the effects on BP.
authors.affiliation: General Hospital, Santa Casa Misericórdia of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Lílian Soares
authors.initials: LS
authors.lastname: da Costa
authors.forename: Monica Amorim
authors.initials: MA
authors.lastname: de Oliveira
authors.forename: Valéria Siqueira Martins
authors.initials: VS
authors.lastname: Rubim
authors.forename: Maurício
authors.initials: M
authors.lastname: Wajngarten
authors.forename: José Mendes
authors.initials: JM
authors.lastname: Aldrighi
authors.forename: Giuseppe M
authors.initials: GM
authors.lastname: Rosano
authors.forename: Cantidio Drumond
authors.initials: CD
authors.lastname: Neto
authors.forename: Otavio Celso Eluf
authors.initials: OC
authors.lastname: Gebara
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D018592:Cross-Over Studies; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017698:Postmenopause; D020849:Raloxifene Hydrochloride / Q000494:pharmacology* / Q000627:therapeutic use*; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology* / Q000627:therapeutic use*; D014655:Vascular Resistance
chemical_list: D020845:Selective Estrogen Receptor Modulators; D020849:Raloxifene Hydrochloride