title: YM-193221, a novel antifungal antibiotic produced by Pseudallescheria ellipsoidea.
abstract: A novel antifungal antibiotic, YM-193221, was found in the culture broth of a fungus, Pseudallescheria ellipsoidea. The structure of the antibiotic was determined through several spectroscopic experiments as 2-dimethylamino-1-(4-hydroxyphenyl)-8,10-dimethyl-6-dodecene-3-one. YM-193221 exhibited potent antifungal activity against Candida albicans and also inhibited mannan synthesis in the yeast cell wall.
authors.affiliation: Analysis & Metabolism Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 21 Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan. kamigiri@yamanouchi.co.jp
authors.forename: Kazuma
authors.initials: K
authors.lastname: Kamigiri
authors.forename: Kouichi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Hisao
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Koji
authors.initials: K
authors.lastname: Nagai
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kenichi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects; D002473:Cell Wall / Q000187:drug effects / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D008351:Mannans / Q000096:biosynthesis; D008826:Microbial Sensitivity Tests; D010627:Phenethylamines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D011541:Pseudallescheria / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: C494516:2-dimethylamino-1-(4-hydroxyphenyl)-8,10-dimethyl-6-dodecene-3-one; D000935:Antifungal Agents; D007659:Ketones; D008351:Mannans; D010627:Phenethylamines