[NO, a major regulator of metabolic and cardiovascular homeostasis].
Obesity and insulin resistance are reaching epidemic proportions worldwide. Over the past decade, nitric oxide (NO) has emerged as a key player in the regulation of the metabolic and cardiovascular homeostasis. Here we will review recent data obtained in mice with disruption of the genes encoding for each of the three nitric oxide synthase isoforms. These data demonstrate that both defective and augmented NO synthesis have detrimental effects on the regulation of the metabolic and cardiovascular system. These observations provide the rationale for the use of NO-donors and/or inhibitors of NO overproduction in the treatment of insulin resistance.
Thalmann
Sébastien
S
Département de médecine interne et Botnar Center.
Jayet
Pierre-Yves
PY
Duplain
Hervé
H
Turini
Pierre
P
Sartori
Claudio
C
Vollenweider
Peter
P
Scherrer
Urs
U
D002320:Cardiovascular Physiological Phenomena; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000503:physiopathology; D009569:Nitric Oxide / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000494:pharmacology*; D010641:Phenotype
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase