title: Individualised unsupervised exercise training in adults with cystic fibrosis: a 1 year randomised controlled trial.
abstract: BACKGROUND
  Short term studies of exercise training have shown benefits in cystic fibrosis. Transferring exercise programmes to the community and sustaining them long term is a challenge for the patient. The effectiveness of an individualised unsupervised home based exercise programme was examined in adults with cystic fibrosis over a 1 year period.
  
  
  METHODS
  Subjects were randomised to undertake three sessions per week of upper and lower body exercise based on individualised preferences (n = 30) or to a control group (n = 18). They were evaluated at baseline and at 12 months. The primary outcome measure was improved fitness as assessed by change in blood lactate concentration at the end of an identical constant work rate for both arm and leg ergometric testing. Secondary outcome measurements were heart rate and pulmonary function.
  
  
  RESULTS
  For leg exercise, significant differences were seen at 12 months between the active and control groups in the mean (SE) change in blood lactate levels (-0.38 (0.23) mmol/l v 0.45 (0.25) mmol/l, p<0.05) and heart rate (-4.8 (2.5) bpm v 3.4 (2.5) bpm, p<0.05), confirming a training effect. For arm ergometry there was no change in lactate levels at 12 months but there was a significant difference in forced vital capacity (46 (72) ml v -167 (68) ml, p<0.05).
  
  
  CONCLUSIONS
  A training effect, as measured by a reduction in lactate levels and heart rate, can be achieved with unsupervised individualised home exercise in adults with cystic fibrosis. A benefit to pulmonary function was observed and together these findings suggest that exercise programmes should be encouraged as an important component of care in cystic fibrosis.
authors.affiliation: The Royal Shrewsbury Hospital, Shrewsbury SY3 8XQ, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Moorcroft
authors.forename: M E
authors.initials: ME
authors.lastname: Dodd
authors.forename: J
authors.initials: J
authors.lastname: Morris
authors.forename: A K
authors.initials: AK
authors.lastname: Webb
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003550:Cystic Fibrosis / Q000503:physiopathology / Q000534:rehabilitation*; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods*; D005541:Forced Expiratory Volume / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D014797:Vital Capacity / Q000502:physiology