[The role of the semi natural cycle as option of treatment of patients with a poor prognosis for successful in vitro fertilization].
OBJECTIVE
To evaluate the efficacy of semi natural cycle as option of treatment for the patients who have a poor prognosis to controlled ovarian hyperstimulation (COH).


METHODS
Prospective study. Sixty-six patients with an ovulatory cycle who presented either altered ovarian status (AOS) or implantation failure (IMF) and had carried out a total of 133 semi natural IVF cycles were included. Once follicular dominance was established, the growth of this follicule was controlled by administration of the GnRH antagonist with exogenous gonadotrophins.


RESULTS
Groups AOS (n = 47) and IMF (n = 19) were similar with regard to oocyte pickup rate (81.2% and 81.1%), the oocyte recovery rate (61.4% and 64.8%) and clinical pregnancies per oocyte pickups rate (15.4% and 16.6%), respectively.


CONCLUSIONS
The semi natural cycle appears as option of treatment for patients who have a poor prognosis for successful in vitro fertilization.
Castelo-Branco
A
A
Service de Gynécologie-Obstétrique de Médecine de la Reproduction, France.
Frydman
N
N
Kadoch
J
J
Le Du
A
A
Fernandez
H
H
Fanchin
R
R
Frydman
R
R
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D005260:Female; D005307:Fertilization in Vitro; D005498:Follicular Phase; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D011446:Prospective Studies
D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone