Multimodal strategy for managing meningiomas in the elderly.
BACKGROUND
The incidence of brain tumors in elderly patients is increasing. It has become possible to treat meningiomas in the elderly by several modalities. We developed a successful multimodal strategy to treat these patients.


METHODS
We registered 35 patients with meningiomas. Symptomatic meningiomas were treated surgically at the time of diagnosis (n=19). Of the 16 asymptomatic meningiomas, 5 were removed at the time of diagnosis. The other asymptomatic meningiomas (n=11) were treated conservatively and when the tumors increased in size, surgical treatment was considered. "Operated" patients with residual or recurrent tumors underwent radiosurgery with a gamma knife.


RESULTS
Surgical mortality and morbidity were 4% and 16%, respectively. Of the 25 "operated" patients, 21 (84.0%) had a good Karnofsky scale (> or =80%) at discharge. In all but two of the 11 patients with asymptomatic, conservatively treated meningiomas, the tumors did not increase during the follow-up period. Gamma knife radiosurgery, performed to treat 3 residual and 1 recurrent tumor, resulted in very good tumor control and none of the tumors increased after gamma knife surgery.


CONCLUSIONS
Meningiomas in elderly patients require a multimodal approach. Our strategy, which includes surgery, radiosurgery, and conservative treatment, resulted in good tumor control and made it possible for patients to pursue their activities of daily life.
Sonoda
Y
Y
Department of Neurosurgery, Yamagata University School of Medicine, Yamagata, Japan.
Sakurada
K
K
Saino
M
M
Kondo
R
R
Sato
S
S
Kayama
T
T
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy / Q000706:statistics & numerical data / Q000639:trends; D003663:Decision Trees; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D008579:Meningioma / Q000532:radiotherapy* / Q000601:surgery*; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology; D016634:Radiosurgery / Q000706:statistics & numerical data; D016896:Treatment Outcome