Regulation of immunity by lysosphingolipids and their G protein-coupled receptors.
T and B lymphocytes, as well as endothelial cells, express distinctive profiles of G protein-coupled receptors for sphingosine 1-phosphate, which is a major regulator of T cell development, B and T cell recirculation, tissue homing patterns, and chemotactic responses to chemokines. The capacity of drugs that act on type 1 sphingosine 1-phosphate receptors to suppress organ graft rejection in humans and autoimmunity in animal models without apparent impairment of host defenses against infections suggests that this system is a promising target for new forms of immunotherapy.
Goetzl
Edward J
EJ
Department of Medicine, UCSF, San Francisco, California, USA. egoetzl@itsa.ucsf.edu
Rosen
Hugh
H
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D007109:Immunity / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000276:immunology*; D049349:Receptors, Lysosphingolipid / Q000276:immunology; D013107:Sphingolipids / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology
D043562:Receptors, G-Protein-Coupled; D049349:Receptors, Lysosphingolipid; D013107:Sphingolipids