title: Synthesis of trehalose-based compounds and their inhibitory activities against Mycobacterium smegmatis.
abstract: The synthesis of a library of trehalose-based compounds has been accomplished, and their activities against Mycobacterium smegmatis have been determined. A preliminary structure-activity relationship (SAR) is reported. Despite not having a potent lead, one of the trehalose derivatives displays strong activity when applied with isoniazid (INH), which is known to have low sterilizing activity. The bacteriocidal nature of our compounds against Mycobacterium may be significant for the development of new therapies against tuberculosis.
authors.affiliation: Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, UT 84322-0300, USA.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Wang
authors.forename: Bryan
authors.initials: B
authors.lastname: Elchert
authors.forename: Yu
authors.initials: Y
authors.lastname: Hui
authors.forename: Jon Y
authors.initials: JY
authors.lastname: Takemoto
authors.forename: Mekki
authors.initials: M
authors.lastname: Bensaci
authors.forename: John
authors.initials: J
authors.lastname: Wennergren
authors.forename: Huiwen
authors.initials: H
authors.lastname: Chang
authors.forename: Ravi
authors.initials: R
authors.lastname: Rai
authors.forename: Cheng-Wei Tom
authors.initials: CW
authors.lastname: Chang
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004305:Dose-Response Relationship, Drug; D007538:Isoniazid; D008826:Microbial Sensitivity Tests; D020102:Mycobacterium smegmatis / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014199:Trehalose / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D014199:Trehalose; D007538:Isoniazid