Liverpool University Neuroleptic Side-Effect Rating Scale (LUNSERS) as a subjective measure of drug-induced parkinsonism and akathisia.
The Liverpool University Neuroleptic Side-Effect Rating Scale (LUNSERS) was examined for its usefulness as a subjective measure of drug-induced parkinsonism and akathisia. Eighty-three subjects were assessed using the LUNSERS, the Simpson-Angus Scale (SAS) and the Barnes Akathisia Rating Scale (BARS), before and after a 6-week treatment with olanzapine. Significant correlations were found between the changes in scores of parkinsonism items of LUNSERS and SAS. The changes in scores of akathisia item (restlessness), extrapyramidal side effects (EPS) subscale and psychic side-effects subscale of LUNSERS were significantly correlated with those of the BARS. 'Shakiness', one item of the EPS subscale of LUNSERS, correctly classified between parkinsonism and non-parkinsonism groups with 81.0% accuracy. A combination of four items included in EPS and psychic side-effect subscales of LUNSERS identified akathisia and non-akathisia groups with 76.2% accuracy. These results suggest that the EPS and psychic side-effect subscales of LUNSERS may be useful in screening for drug-induced parkinsonism and akathisia.
Jung
Hee-Yeon
HY
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
Kim
Jong-Hoon
JH
Ahn
Yong-Min
YM
Kim
Seong-Chan
SC
Hwang
Samuel S
SS
Kim
Yong-Sik
YS
D000328:Adult; D017109:Akathisia, Drug-Induced / Q000175:diagnosis* / Q000188:drug therapy; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use; D015897:Comorbidity; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D000077152:Olanzapine; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D010358:Patient Participation; D011569:Psychiatric Status Rating Scales; D013997:Time Factors; D016896:Treatment Outcome
D001569:Benzodiazepines; D000077152:Olanzapine