Application of residual dipolar couplings in organic compounds.
Residual dipolar couplings (RDCs) induced by anisotropic media are a powerful tool for the structure determination of biomolecules through NMR spectroscopy. Recent advances have proven it to be a valuable tool for determination of the stereochemistry of organic molecules. By simple inspection or order matrix calculations, RDCs provide unambiguous information about the relative configurations or complete stereochemistry of organic compounds.
Yan
Jiangli
J
Triad Therapeutics, Inc., San Diego, CA 92121, USA. jiangli.yan@pfizer.com
Zartler
Edward R
ER
D005960:Glucosides / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008968:Molecular Conformation; D009930:Organic Chemicals / Q000737:chemistry*; D012996:Solutions; D012997:Solvents
D005960:Glucosides; D009930:Organic Chemicals; D012996:Solutions; D012997:Solvents