title: History of obesity as a risk factor for both carotid atherosclerosis and microangiopathy.
abstract: As a westernized lifestyle becomes widespread in Japan, the number of individuals with obesity, as well as type 2 diabetes, is rapidly increasing. In this investigation, we studied the prevalence of obesity and its association with the development of diabetic macroangiopathy and microangiopathy. The clinical records of 634 patients in our hospital with type 2 diabetes were surveyed. The relationship between obesity and diabetic retinopathy and nephropathy and macroangiopathy (carotid artery intima-media thickness, IMT) was examined using univariate and multivariate analysis. A body mass index (BMI) > or = 25 kg/m2 was used as the diagnostic criterion for obesity. The prevalence of obesity at the time of the survey was 35% and a history of obesity was reported in 70% of the survey population. Multiple regression analysis revealed that the maximum BMI was significantly correlated with IMT thickening. The prevalence of nephropathy in previously obese patients was significantly higher than in non-obese patients. The maximum BMI was significantly associated with the development of retinopathy and nephropathy, as shown by logistic regression analysis. This suggests that a history of obesity may be an important risk factor for the development of micro- and macroangiopathy in Japanese with type 2 diabetes.
authors.affiliation: The First Department of Medicine, Wakayama Medical University, Kimiidera 811-1, Wakayama, PO 641-8509, Japan.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Ogawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Ueda
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Sasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Okamoto
authors.forename: Hisao
authors.initials: H
authors.lastname: Wakasaki
authors.forename: Eisaku
authors.initials: E
authors.lastname: Matsumoto
authors.forename: Hiroto
authors.initials: H
authors.lastname: Furuta
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hanabusa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishi
authors.forename: Kishio
authors.initials: K
authors.lastname: Nanjo
mesh_terms: D002340:Carotid Artery Diseases / Q000453:epidemiology*; D048909:Diabetes Complications / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008019:Life Style; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D006442:Glycated Hemoglobin