title: [Barrett's esophagus].
abstract: BACKGROUND
  It is widely accepted that long segments of Barrett's esophagus are caused by end-stage gastroesophageal reflux disease (GERD), but little is known about the correlation of severity of GERD and extent of metaplasia.
  
  
  METHODS
  Twenty normal volunteers and 142 patients with different extent of intestinal metaplasia (39 with intestinal metaplasia limited to the esophagogastric junction, 48 with short segments of Barrett's esophagus, and 55 with long segments) underwent manometry and combined pH-bilirubin monitoring.
  
  
  RESULTS
  The extent of intestinal metaplasia correlated to the exposition of gastric and duodenal juice in the esophagus and inversely with a competent lower esophageal sphincter.
  
  
  CONCLUSIONS
  The extent of intestinal metaplasia is related to the severity of GERD.
authors.affiliation: Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München. wkauer@nt1.chir.med.tu-muenchen.de
authors.forename: W K H
authors.initials: WK
authors.lastname: Kauer
authors.forename: H J
authors.initials: HJ
authors.lastname: Stein
authors.forename: H J
authors.initials: HJ
authors.lastname: Dittler
authors.forename: J R
authors.initials: JR
authors.lastname: Siewert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D001663:Bilirubin / Q000032:analysis*; D004383:Duodenogastric Reflux / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D004943:Esophagogastric Junction / Q000473:pathology* / Q000503:physiopathology*; D004947:Esophagus / Q000473:pathology*; D005260:Female; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008365:Manometry; D008679:Metaplasia; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D012307:Risk Factors; D013223:Statistics as Topic
chemical_list: D001663:Bilirubin