title: Microinvasive Paget's disease.
abstract: BACKGROUND
  Microinvasive squamous cell carcinoma of the vulva is defined as stromal invasion < or =1 mm and is treated by wide local resection. Whether criteria for microinvasive squamous cell carcinoma can be applied to Paget's disease of the vulva is unknown because of the rarity of that disease.
  
  
  METHODS
  We initially evaluated three cases of microinvasive Paget's disease by using sentinel lymph node (SLN) analysis. The SLNs in two patients were negative; and these patients had no recurrence of invasive or metastatic Paget's disease. The other patient had a positive SLN (the only positive lymph node) and subsequently received complete lymph node dissection of the groin bilaterally.
  
  
  CONCLUSIONS
  Evaluation of SLNs may be valid for evaluating microinvasive Paget's disease.
authors.affiliation: Department of Obstetrics and Gynecology, Kaiser Permanente Medical Center, 280 W. MacArthur Boulevard, Oakland, CA 94611, USA. Thomas.Ewing@kp.org
authors.forename: Thomas
authors.initials: T
authors.lastname: Ewing
authors.forename: John
authors.initials: J
authors.lastname: Sawicki
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ciaravino
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Rumore
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010145:Paget Disease, Extramammary / Q000473:pathology* / Q000601:surgery; D021701:Sentinel Lymph Node Biopsy; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery