title: Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.
abstract: Investigation of weak screening hits led to the identification of N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides and N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-N'-benzylureas as potent, selective ligands for the human CCR5 chemokine receptor.
authors.affiliation: Respiratory and Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.
authors.forename: Jeremy N
authors.initials: JN
authors.lastname: Burrows
authors.forename: John G
authors.initials: JG
authors.lastname: Cumming
authors.forename: Shaun M
authors.initials: SM
authors.lastname: Fillery
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Hamlin
authors.forename: Julian A
authors.initials: JA
authors.lastname: Hudson
authors.forename: Ruth J
authors.initials: RJ
authors.lastname: Jackson
authors.forename: Sharon
authors.initials: S
authors.lastname: McLaughlin
authors.forename: John S
authors.initials: JS
authors.lastname: Shaw
mesh_terms: D000577:Amides / Q000737:chemistry*; D006801:Humans; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D019713:Receptors, CCR5 / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014508:Urea / Q000737:chemistry*
chemical_list: D000577:Amides; D010880:Piperidines; D019713:Receptors, CCR5; D014508:Urea