title: Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya.
abstract: This review outlines the recent developments in uncovering the enzymes and intermediates involved in fluorometabolite biosyntheses in the bacterium Streptomyces cattleya. A particular emphasis is placed on the purification and characterisation of the fluorinase, the C-F bond forming enzyme which initiates the biosynthesis. Nature has hardly developed a biochemistry around fluorine, yet fluorinated organics are important commercial entities, therefore a biotransformation from inorganic to organic fluorine is novel and of contemporary interest.
authors.affiliation: School of Chemistry and Centre for Biomolecular Science, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK.
authors.forename: Hai
authors.initials: H
authors.lastname: Deng
authors.forename: David
authors.initials: D
authors.lastname: O'Hagan
authors.forename: Christoph
authors.initials: C
authors.lastname: Schaffrath
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000378:metabolism*; D005461:Fluorine; D006845:Hydrocarbons, Fluorinated / Q000378:metabolism*; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000378:metabolism*; D013302:Streptomyces / Q000201:enzymology* / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D006845:Hydrocarbons, Fluorinated; D005461:Fluorine; D010088:Oxidoreductases; C495766:fluorinase