Effects of loud noise exposure on DNA integrity in rat adrenal gland.
Loud noise is generally considered an environmental stressor causing negative effects on acoustic, cardiovascular, nervous, and endocrine systems. In this study, we investigated the effects of noise exposure on DNA integrity in rat adrenal gland evaluated by the comet assay. The exposure to loud noise (100 dBA) for 12 hr caused a significant increase of DNA damage in the adrenal gland. Genetic alterations did not decrease 24 hr after the cessation of the stimulus. We hypothesize that an imbalance of redox cell status is responsible for the induction and persistence of noise-induced cellular damage.
Frenzilli
Giada
G
Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Pisa, Italy. giada@biomed.unipi.it
Lenzi
Paola
P
Scarcelli
Vittoria
V
Fornai
Francesco
F
Pellegrini
Antonio
A
Soldani
Paola
P
Paparelli
Antonio
A
Nigro
Marco
M
D000311:Adrenal Glands / Q000473:pathology*; D000818:Animals; D020552:Comet Assay; D004249:DNA Damage; D004781:Environmental Exposure; D008297:Male; D009622:Noise / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar