title: Viral hijacking of G-protein-coupled-receptor signalling networks.
abstract: Viruses use a surprising diversity of approaches to hijack G-protein-coupled receptors and harness their activated intracellular signalling pathways. All of these approaches ultimately function to ensure viral replicative success and often contribute to their pathogenesis. Indeed, a single virus might deploy a repertoire of these strategies to regulate key intracellular survival, proliferative and chemotactic pathways. Understanding the contribution of these biochemical routes to viral pathogenesis might facilitate the development of effective target-specific therapeutic strategies against viral diseases.
authors.affiliation: Cell Growth Regulation Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Room 211, Bethesda, Maryland 20892-4330, USA.
authors.forename: Akrit
authors.initials: A
authors.lastname: Sodhi
authors.forename: Silvia
authors.initials: S
authors.lastname: Montaner
authors.forename: J Silvio
authors.initials: JS
authors.lastname: Gutkind
mesh_terms: D017209:Apoptosis / Q000502:physiology; D018925:Chemokines / Q000378:metabolism; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D019707:Receptors, Chemokine / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology*; D014779:Virus Replication / Q000502:physiology*; D014780:Viruses / Q000378:metabolism* / Q000472:pathogenicity
chemical_list: D018925:Chemokines; D015699:HIV Envelope Protein gp120; D019707:Receptors, Chemokine; D043562:Receptors, G-Protein-Coupled