The relationship between HIV type 1 disease progression and V3 serotype in a rural Ugandan cohort.
Antigenic properties of the V3 region are reflected by HIV-1 serotypes. These may represent biological properties of the virus. We serotyped HIV-1 in 142 serum samples from participants in a rural Uganda cohort who seroconverted between August 1991 and December 2001. Clinical progression was assessed using Cox proportional hazards and Kaplan-Meier methods. Of 112 (79%) samples successfully serotyped, 36% were serotype A, 17% serotype B, 18% serotype C, and 29% serotype D. Median follow-up time, age at enrollment, and first CD4 count were similar in each serotype group. Clinical progression was faster for serotype D than other serotypes to AIDS or death, death, and CD4 count <200 cells/mm(3) (all p < 0.05). HIV-1 V3 serotypes are associated with variations in the pathogenicity of HIV-1 and should be taken into account when studying the biological relevance of HIV-1 diversity.
Senkaali
David
D
Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe, Uganda.
Muwonge
Richard
R
Morgan
Dilys
D
Yirrell
David
D
Whitworth
James
J
Kaleebu
Pontiano
P
D000328:Adult; D000595:Amino Acid Sequence; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000276:immunology*; D015658:HIV Infections / Q000401:mortality / Q000503:physiopathology* / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology*; D012424:Rural Population; D012703:Serotyping; D014454:Uganda
D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments