title: Haemostatic alterations in colorectal cancer: perspectives for future treatment.
abstract: The role of the haemostatic system in colorectal cancer (CRC) is reviewed. Correlations between the activation of the haemostatic system and overall survival have been suggested. Experimental studies indicate that the haemostatic system plays a key role in growth, invasion and dissemination of tumour cells, and in tumour related angiogenesis. Additional activation by the surgical trauma and postoperative infections are discussed. Finally, anti-cancer modalities directed against regulation of the haemostatic system in CRC are considered.
authors.affiliation: Surgical Immunology Laboratory, Department of Surgical Gastroenterology, Hvidovre University Hospital, Copenhagen, Denmark. jly@dadlnet.dk
authors.forename: Jakob
authors.initials: J
authors.lastname: Lykke
authors.forename: Hans Jørgen
authors.initials: HJ
authors.lastname: Nielsen
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D007239:Infections / Q000209:etiology; D010447:Peptide Hydrolases / Q000502:physiology; D011183:Postoperative Complications; D013925:Thromboplastin / Q000378:metabolism; D020246:Venous Thrombosis / Q000209:etiology
chemical_list: D013925:Thromboplastin; D010447:Peptide Hydrolases