title: Beta2 adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese.
abstract: BACKGROUND
  There is considerable variability in individual response to antihypertensive agents. The reason for this is not known, but may be related to individual genetic variability. This study examined whether the therapeutic efficacy of benazepril on essential hypertension is modified by beta2 adrenergic receptor gene (ADRB2) Arg16Gly (R16G) polymorphism.
  
  
  RESULTS
  We conducted a family-based study of 321 and 610 hypertensive subjects from Yuexi and Huoqiu Counties of Anhui, China, respectively. Both systolic and diastolic blood pressures (SBP and DBP) before and after a 15-day benazepril treatment were measured. ADRB2 R16G genotypes were determined for all subjects. ADRB2 G16 allele frequency was found to be 41.0% and. 47.4% in Huoqiu and Yuexi, respectively. In Yuexi family-based association test (FBAT) revealed that the G16 allele was associated with a greater DBP decrease in response to a 15-day benazepril treatment (Z = 2.12, P = 0.03), and the data were consistent with a dominant inheritance model. A similar trend was observed in Huoqiu Chinese, but the magnitudes of effects were smaller and did not reach statistical significance. The FBAT results were further confirmed by using a generalized estimating equation model.
  
  
  CONCLUSIONS
  Our family-based study provided the first evidence that ADRB2 R16G polymorphism may play an important role in DBP response to benazepril treatment, although the magnitude of the effect appears to be modified by other risk factors such as plasma lipid and glucose profiles.
authors.affiliation: School of Life Science, University of Science and Technology of China, Hefei, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Huang
authors.forename: Houxun
authors.initials: H
authors.lastname: Xing
authors.forename: Ke
authors.initials: K
authors.lastname: Hao
authors.forename: Shaojie
authors.initials: S
authors.lastname: Peng
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.forename: Wenwei
authors.initials: W
authors.lastname: Guang
authors.forename: Aiqun
authors.initials: A
authors.lastname: Huang
authors.forename: Xiumei
authors.initials: X
authors.lastname: Hong
authors.forename: Yuanping
authors.initials: Y
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianping
authors.initials: J
authors.lastname: Li
authors.forename: Changzhong
authors.initials: C
authors.lastname: Chen
authors.forename: Binyan
authors.initials: B
authors.lastname: Wang
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.forename: Yunxian
authors.initials: Y
authors.lastname: Yu
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Guoying
authors.initials: G
authors.lastname: Zhu
authors.forename: Yong
authors.initials: Y
authors.lastname: Huo
authors.forename: Dafang
authors.initials: D
authors.lastname: Chen
authors.forename: Yongtai
authors.initials: Y
authors.lastname: Hou
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Tianhua
authors.initials: T
authors.lastname: Niu
authors.forename: Xiping
authors.initials: X
authors.lastname: Xu
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D044466:Asian People / Q000235:genetics; D001552:Benzazepines / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
chemical_list: D000959:Antihypertensive Agents; D001552:Benzazepines; D018343:Receptors, Adrenergic, beta-2; C044946:benazepril