Feasibility study of ultrasonic fatty liver biopsy: texture vs. attenuation and backscatter.
The objective of this study was to compare textural to attenuation/backscatter indices of fatty liver correlated to histology to suggest the better approach for an objective noninvasive ultrasonic "biopsy". Forty-four patients with severe steatosis by histopathology were selected for this study. Ten patients had "pure" fatty liver and 34 had in addition fibrosis and/or inflammation. Ultrasonic images were acquired before needle insertion. The ROI used for biopsy was marked on the ultrasonic image and characterized by three attenuation/backscatter and 18 textural related indices. Statistical analysis was performed using logistic regression. Twenty-one healthy subjects served as control. The attenuation/backscatter indices were superior to textural indices in differentiating between the categories studied. Pure fatty livers could be reliably identified (AUC = 1, SE = 0). Among the 18 textural indices, "co-occurrences sum entropy" and "co-occurrences entropy" presented the best results. Attenuation/backscatter based indices appear to have better potential than the textural based indices.
Gaitini
Diana
D
Department of Medical Imaging, Rambam Medical Center and Faculty of Medicine, Haifa, Israel. D_Gaitini@Rambam.Health.Gov.IL
Baruch
Yaacov
Y
Ghersin
Eduard
E
Veitsman
Ella
E
Kerner
Hedvika
H
Shalem
Bruria
B
Yaniv
Geva
G
Sarfaty
Chen
C
Azhari
Haim
H
D019540:Area Under Curve; D001707:Biopsy, Needle / Q000379:methods; D005234:Fatty Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D006505:Hepatitis / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014465:Ultrasonics; D018084:Ultrasonography, Interventional