title: Synthesis, antitumour and antimicrobial activities of new peptidyl derivatives containing the 1,3-benzodioxole system.
abstract: Two series of 5 and 6-substituted 1,3-benzodioxole peptidyl derivatives were synthesized and evaluated as antitumour and antimicrobial agents. The compounds that could be conveniently prepared in a few steps processes from natural safrole have been characterised by IR and 1H-NMR spectroscopy. In vivo antitumor activity tests showed that some of the compounds were able to inhibit carcinoma S-180 tumour growth in mice. The in vitro antimicrobial activity of all compounds revealed that they are able to promote the growth of some organisms, including Bacillus subtilis.
authors.affiliation: Labsinfa, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco--Rua Prof. Artur Sá S/N, CDU, 50740-520, Recife, Pernambuco, Brazil. aclb@ufpe.br
authors.forename: Ana Cristina Lima
authors.initials: AC
authors.lastname: Leite
authors.forename: Kezia Peixoto
authors.initials: KP
authors.lastname: da Silva
authors.forename: Ivone A
authors.initials: IA
authors.lastname: de Souza
authors.forename: Janete Magali
authors.initials: JM
authors.lastname: de Araújo
authors.forename: Dalci José
authors.initials: DJ
authors.lastname: Brondani
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D001522:Behavior, Animal / Q000187:drug effects; D004149:Dioxoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D051379:Mice; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D012451:Safrole / Q000737:chemistry; D012510:Sarcoma 180 / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004149:Dioxoles; C496326:N-(6-allyl-1,3-benzodioxol-5-yl)-N-(tert-butoxycarbonyl)phenylalaninamide; D010455:Peptides; D010649:Phenylalanine; D012451:Safrole