title: [Clinical significance of cevimeline hydrochloride in the treatment of dry mouth in patients with Sjögren's syndrome].
abstract: To evaluate the efficacy and safety of cevimeline hydrochloride for the treatment of dry mouth in patients with Sjögren's syndrome (SS), eight SS patients received 30 mg of cevimeline twice or three times daily for 24 weeks. Six out of the eight patients had improvement in dry mouth. Five patients had more than 20% increase in saliva secretion. In the assessment of salivary gland scintigraphy, three patients showed improvement. There was a significant negative correlation between the improvement of saliva secretion and the severity of tissue damage assessed by MR sialography (r= - 0.754, p<0.05). One patient stopped cevimeline at 4 weeks because of headache and nausea. There was no significant change in laboratory data. Cevimeline is safe and effective medicine for dry mouth in patients with SS, in particular, with less severe salivary gland destruction.
authors.affiliation: Division of Hematology & Immunology, Department of Internal Medicine, Kanazawa Medical University.
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Ogawa
authors.forename: Kumiko
authors.initials: K
authors.lastname: Shimoyama
authors.forename: Hiromi
authors.initials: H
authors.lastname: Karasawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Fukushima
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Masaki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Wano
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hirose
authors.forename: Susumu
authors.initials: S
authors.lastname: Sugai
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D018721:Muscarinic Agonists / Q000627:therapeutic use*; D011812:Quinuclidines / Q000627:therapeutic use*; D012859:Sjogren's Syndrome / Q000188:drug therapy*; D013876:Thiophenes / Q000627:therapeutic use*; D014987:Xerostomia / Q000188:drug therapy*
chemical_list: D018721:Muscarinic Agonists; D011812:Quinuclidines; D013876:Thiophenes; C059240:cevimeline