title: Asymmetric synthesis of 2-alkyl- and 2-aryl-3-aminopropionic acids (beta2-amino acids) from (S)-N-acryloyl-5,5-dimethyloxazolidin-2-one SuperQuat derivatives.
abstract: Conjugate addition of lithium amides to (S)-N-acryloyl- or (S)-N-2'-alkylacryloyloxazolidinones and alkylation or protonation of the resulting enolates with 2-pyridone respectively provides a highly stereoselective and product complementary route to a range of (R)- and (S)-2-alkyl-3-aminopropionic acids in good yield and in high ee.
authors.affiliation: Department of Organic Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: James E
authors.initials: JE
authors.lastname: Beddow
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Davies
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Smith
authors.forename: Angela J
authors.initials: AJ
authors.lastname: Russell