[In-vitro evaluation of haemocompatibility of biomaterials].
In-vitro test is usually conducted as a preliminary screening test in the evaluation of the haemocompatibility of biomaterials for its short-term consuming, convenience and less expense. The selection of appropriate model for blood-biomaterial interaction, the choice of sensitive and specific parameters, and the minimization of additional blood activation are most important in the in-vitro test. In addition, the time and the style of blood-biomaterial interaction, the choice of sensitive and specific parameters, and the minimization of additional blood activation are most important in the in-vitro test. In addition, the time and the style of blood-biomaterial interaction, the selection of primary reference materials and the shear rate should be considered. In recent years, though great progress has been made in the in-vitro evaluation of haemocompatibility of biomaterials, all these influencing factor should be standardized for more effective evaluation of the haemocompatibility of biomaterials.
Xu
Jianxia
J
National Institute for Control of Pharmaceutical and Biological Products, Beijing 100050, China.
Wang
Chunren
C
Xi
Tingfei
T
D001672:Biocompatible Materials; D005069:Evaluation Studies as Topic; D006801:Humans; D008422:Materials Testing / Q000592:standards*
D001672:Biocompatible Materials