Serum leptin level in patients with functional dyspepsia.
BACKGROUND/GOAL: Previous studies have shown that leptin plays a major role in the amount of food consumption. Recently, leptin and its receptors have been found in the human gastric mucosa. The aim of this study was to seek any possible correlation between serum leptin level and subtypes and pathological findings in functional dyspepsia.


METHODS
In a prospective study, we randomly select 44 patients as dysmotility-like and ulcer-like dyspepsia (according to ROME II criteria) in two equivalent groups and compared them with 22 healthy volunteers control group who matched the patients in relation to age, sex and body mass index. From each patient, a fasting blood sample for leptin level and two antral biopsies for evaluating the intensity of gastritis and Helicobacter pylori infection were provided and compared with the control group.


RESULTS
Compared to the control group, serum leptin level was significantly higher in patients with dysmotility-like dyspepsia (P < 0.05). Leptin level were also significantly correlated with the presence of gastritis and H. pylori infection (P < 0.05).


CONCLUSIONS
Leptin may have a role in the pathogenesis of the dysmotility variety of non-ulcer dyspepsia through mechanisms other than H. pylori infection. Further studies based on gastric leptin immunohistochemistry may need correlation between symptoms of functional dyspepsia and gastric leptin expression.
Lankarani
K B
KB
Gastroenterohepatology Research Centre, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. lankaran@sums.ac.ir
Moghadami
M
M
Masoumpoor
M
M
Geramizadeh
B
B
Omrani
G R
GR
D000293:Adolescent; D000328:Adult; D000368:Aged; D004415:Dyspepsia / Q000097:blood* / Q000473:pathology*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D020738:Leptin