[Development research on oxidase functional model iron complexes].
This paper describes research performed in the Laboratory of Organic Chemistry, Showa Pharmaceutical University. Oxidation reactions involving the oxidase can be divided roughly into two kinds of reactions: The first involves electron removal from an aromatic ring or an active CH-bond. The other reaction involves hydrogen abstraction from an inactive CH-bond. The oxidase models, Fe(DMF)(3)Cl(2)(1+) and Fe(AN)(6)(3+)/AN, which we have synthesized, have been shown to work by the former mechanism, and the models Fe(AN)(6)(3+)-IO(4)(-)/AN, Fe(AN)(6)(2+)-Ac(2)O-H(2)O(2)/AN, Fe(AN)(6)(2+)-2PAH-5Py-Ac(2)O-H(2)O(2)/AN, Fe(PA)(3)(OH(2))-H(2)O(2)/AN and Fe(PA)(3)(OH(2))-O(2)-electrolysis/AN do so by the latter mechanism. Further, we found some iron (II or III)picolinate-H(2)O(2)/AN complexes have the 7 alpha-hydroxylase-like activity.
Kotani
Eiichi
E
Showa Pharmaceutical University, Machida 194-8543, Japan.
D000097:Acetonitriles / Q000138:chemical synthesis / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002790:Cholesterol 7-alpha-Hydroxylase; D004572:Electrolysis; D004583:Electrons; D006859:Hydrogen / Q000737:chemistry; D006860:Hydrogen Bonding; D006861:Hydrogen Peroxide / Q000138:chemical synthesis / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D008956:Models, Chemical; D010084:Oxidation-Reduction; D010088:Oxidoreductases; D019800:Phenol; D010848:Picolinic Acids / Q000138:chemical synthesis / Q000737:chemistry
D000097:Acetonitriles; D010848:Picolinic Acids; D019800:Phenol; D002244:Carbon; D006859:Hydrogen; D006861:Hydrogen Peroxide; D007501:Iron; D010088:Oxidoreductases; D002790:Cholesterol 7-alpha-Hydroxylase; C030614:picolinic acid; C032159:acetonitrile