Pharmacokinetics of telithromycin in plasma and soft tissues after single-dose administration to healthy volunteers.
By use of microdialysis we assessed the concentrations of telithromycin in muscle and adipose tissue to test its ability to penetrate soft tissues. The ratios of the area under the concentration-versus-time curve from 0 to 24 h to the MIC indicated that free concentrations of telithromycin in tissue and plasma might be effective against Streptococcus pyogenes but not against staphylococci and human and animal bite pathogens.
Gattringer
Rainer
R
Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Medical University of Vienna, Vienna, Austria.
Urbauer
Eleonora
E
Traunmüller
Friederike
F
Zeitlinger
Markus
M
Dehghanyar
Pejman
P
Zeleny
Petra
P
Graninger
Wolfgang
W
Müller
Markus
M
Joukhadar
Christian
C
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001798:Blood Proteins / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D006801:Humans; D007202:Indicators and Reagents; D048628:Ketolides / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D017551:Microdialysis; D018482:Muscle, Skeletal / Q000378:metabolism; D011485:Protein Binding; D012015:Reference Standards; D012867:Skin / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D007202:Indicators and Reagents; D048628:Ketolides; C106791:telithromycin