[Anticancer drugs off label used of: what do the experts think about?].
Anticancer drugs off label used in Tenon hospital were analysed by a panel of 12 experts not working at Tenon hospital. They distinguished 3 groups of off-label prescribing according to scientific evidence, labelling anticancer drugs alternative in presence and patient's characteristics: justified off label used (62%), unjustified off label used (26%) and prescriptions for which no consensus had been reached between the experts (12%). Nineteen per cent of unjustified off label used had labelling alternative and 7% did not have anticancer drugs labelling alternative. Questions who experts had to answer to analyse drugs prescribing could be systematically asked when a chemotherapy is prescribed. It could allowed to take into account scientific, economic and ethical requirements. This method proposed by the local drug committee could be used to regulate economic resources and to justify financing of some expensive anticancer drugs.
Debrix
Isabelle
I
Pharmacie, Hôpital Tenon, Paris. isabelle.debris@tnn.ap-hop-paris.fr
André
Thierry
T
Becker
Annie
A
Lotz
Jean-Pierre
JP
Gligorov
Joseph
J
Boukari
Yasmine
Y
Milleron
Bernard
B
Pene
Françoise
F
Flahault
Antoine
A
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004348:Drug Labeling; D011307:Drug Prescriptions; D006801:Humans; D008485:Medical Audit; D009369:Neoplasms / Q000188:drug therapy*; D010606:Pharmacy and Therapeutics Committee
D000970:Antineoplastic Agents