Molecular imaging using magnetic resonance: new tools for the development of tumour therapy.
Molecular imaging - the exploitation of specific molecules as the source of image contrast - promises new insights into disease processes in the laboratory and since the imaging modalities employed are applicable clinically, can be used to translate this knowledge into new diagnostics and treatments in the clinic. This brief review focuses on the use of MR-based molecular imaging techniques for developing tumour therapy. As examples, methods for detecting drug-induced tumour cell apoptosis; the response of tumours and their susceptibilities to an antivascular drug; early signs of tumour immune rejection and methods for detecting immune cell infiltration of tumours are described.
Brindle
K M
KM
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK.
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D051381:Rats