title: [Successful treatment of intravenous cyclophosphamide pulse therapy for lupus myelitis with urinary disturbance and acute confusional state].
abstract: A 18-year-old female had low grade fever, butterfly rush, proteinuria, leukocytopenia and hypocomplimentemia in 1988, and she was diagnosed as systemic lupus erythematosus (SLE) with lupus nephritis (WHOIIb). Treatments with prednisolone and mizoribine resulted in the remission for three years. In May 2001, she presented neurosis and polakisuria despite of the increase of prednisolone to 20 mg/day. Finally, she admitted in our hospital because of manic and repressive state and disorientaion. A brain MRI revealed high intensity lesions in bilateral basal ganglia in T2 weighted images, and cerebrospinal fluid showed elevated protein and IFN-alpha (421 IU/ml). In addition, she manifested neurogenic bladder, muscle weakness and hyperactive deep tendon reflex of bilateral lower limbs due to both supranuclear disorder and hypesthesia under the Th 10 level. Spinal MRI revealed marked atrophy and high intensity signals at the middle to lower thoracic spinal cord in T2 weighted images, indicating complication of lupus myelitis as well as cerebral involvement. Although the symptoms of CNS lupus did not respond to prednisolone, twelve monthly cyclophosphamide pulse therapy (IV-CY) has resolved urinary disturbance, muscle weakness and sensory loss, along with the improvement of both cerebral and spinal MRI images. Lupus myelitis and neurogenic bladder are the rare, but very refractory manifestation among CNS involvement of SLE. We here propose IV-CY as an invaluable choice for the treatment of not only active lupus myelitis but also neurogenic bladder resisted for steroid.
authors.affiliation: The First Department of Internal Medicine, University of Occupational and Environmental Hearth, Japan, School of Medicine.
authors.forename: Mikiko
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Saito
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nakatsuka
authors.forename: Shingo
authors.initials: S
authors.lastname: Nakayamada
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Nakano
authors.forename: Shizuyo
authors.initials: S
authors.lastname: Tsujimura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ota
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000293:Adolescent; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D001523:Mental Disorders / Q000188:drug therapy / Q000209:etiology; D009187:Myelitis / Q000188:drug therapy* / Q000209:etiology*; D020551:Pulse Therapy, Drug; D016896:Treatment Outcome; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D003520:Cyclophosphamide