title: [Olfactory function and olfactory marker protein in patients with chronic sinusitis].
abstract: OBJECTIVE
  To study the pathogenesis of dysosphresia in patients with chronic sinusitis, to discuss the expression and significance of olfaction marker protein in olfactory mucosa.
  
  
  METHODS
  There were 55 cases with chronic sinusitis in the experimental group, and 11 cases in the control. All of them were first tested by subjective method, and then the olfactory marker protein in olfactory mucosa was examined by the method of immunohistochemistry. Tissue sections were observed under optical microscope.
  
  
  RESULTS
  The ratio of dysosphresia in patients with chronic sinusitis was 50.9% (28/55), while by subjective olfactory test, it was 85.5% (47/55). The ratio of dysosphresia in control patients was 9.09% (1/11), by subjective olfactory test, it was 18.2% (2/11). Olfactory marker protein was identified in the olfactory cells and microvillar cells by histochemical and immunohistochemical technique (S-P method).
  
  
  CONCLUSIONS
  The main cause of dysosphresia in patients with chronic sinusitis is the decrease, atrophy and degeneration of the olfactory cells, which lead to the failure of olfactus perception and recognition.
authors.affiliation: Department of Otorhinolaryngology, First Hospital of Inner Mongolia Medical Academy, Huhhot 010050, China. hygao@yahoo.com
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Gao
authors.forename: Xiao-nong
authors.initials: XN
authors.lastname: Zhu
authors.forename: Shi-dong
authors.initials: SD
authors.lastname: Peng
authors.forename: Hu-he
authors.initials: HH
authors.lastname: Zhang
authors.forename: Er-zhong
authors.initials: EZ
authors.lastname: Fan
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: De-min
authors.initials: DM
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D051842:Olfactory Marker Protein / Q000378:metabolism*; D009831:Olfactory Mucosa / Q000503:physiopathology*; D012852:Sinusitis / Q000150:complications / Q000378:metabolism*; D055815:Young Adult
chemical_list: D051842:Olfactory Marker Protein