[Molecules involved in characteristics of naive/memory B cells].
Memory B cells, which carry immunoglobulin somatic hypermutations, generate immunoglobulins rapidly and vigorously in the secondary immune response. We recently highlighted studies confirming that CD27 surface antigen is a memory B-cell marker. By using the memory B-cell marker, peripheral blood B cells were clearly distinguished into naive and memory B cells. The B cells are further separated to three populations by the expressions of CD27 and IgD: IgD+CD27- naive B cells (circulating B cell 1: cB1), IgD+CD27+ unclass-switched memory B cells (cB2, so-called IgM memory B cells) and IgD-CD27+ class-switched memory B cells (cB3, switched memory B cells). Here we show molecules which are involved in characteristics of naive/memory B cells and their functions. This functionally distinct B cell subset and molecules involved in the subset may represent an important mechanism by which quiescent human B cells can initiate and propagate rapid and vigorous immune memory responses, and regulate the synthesis of low/high affinity antibodies.
Agematsu
Kazunaga
K
Department of Infectious Immunology, Graduate School of Medicine Shinshu University.
D015703:Antigens, CD / Q000032:analysis; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D016175:B-Lymphocyte Subsets / Q000737:chemistry*; D006801:Humans; D007072:Immunoglobulin D / Q000032:analysis; D007156:Immunologic Memory / Q000502:physiology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000032:analysis
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; C064228:CD72 protein, human; D007072:Immunoglobulin D; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7