title: Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation.
abstract: A concept in Parkinson's disease postulates that motor cortex may pattern abnormal rhythmic activities in the basal ganglia, underlying the genesis of observed motor symptoms. We conducted a preclinical study of electrical interference in the primary motor cortex using a chronic MPTP primate model in which dopamine depletion was progressive and regularly documented using 18F-DOPA positron tomography. High-frequency motor cortex stimulation significantly reduced akinesia and bradykinesia. This behavioral benefit was associated with an increased metabolic activity in the supplementary motor area as assessed with 18-F-deoxyglucose PET, a normalization of mean firing rate in the internal globus pallidus (GPi) and the subthalamic nucleus (STN), and a reduction of synchronized oscillatory neuronal activities in these two structures. Motor cortex stimulation is a simple and safe procedure to modulate subthalamo-pallido-cortical loop and alleviate parkinsonian symptoms without requiring deep brain stereotactic surgery.
authors.affiliation: URA CEA-CNRS 2210, Service Hospitalier Frédéric Joliot, 91401 Orsay, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Drouot
authors.forename: Satoru
authors.initials: S
authors.lastname: Oshino
authors.forename: Bechir
authors.initials: B
authors.lastname: Jarraya
authors.forename: Laurent
authors.initials: L
authors.lastname: Besret
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kishima
authors.forename: Philippe
authors.initials: P
authors.lastname: Remy
authors.forename: Julien
authors.initials: J
authors.lastname: Dauguet
authors.forename: Jean Pascal
authors.initials: JP
authors.lastname: Lefaucheur
authors.forename: Frédéric
authors.initials: F
authors.lastname: Dollé
authors.forename: Françoise
authors.initials: F
authors.lastname: Condé
authors.forename: Michel
authors.initials: M
authors.lastname: Bottlaender
authors.forename: Marc
authors.initials: M
authors.lastname: Peschanski
authors.forename: Yves
authors.initials: Y
authors.lastname: Kéravel
authors.forename: Philippe
authors.initials: P
authors.lastname: Hantraye
authors.forename: Stéphane
authors.initials: S
authors.lastname: Palfi
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004594:Electrophysiology; D019788:Fluorodeoxyglucose F18; D020267:MPTP Poisoning / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009044:Motor Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology; D010215:Papio; D010300:Parkinson Disease / Q000503:physiopathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D020127:Recovery of Function
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18