[The effect of antitumor polychemotherapy on the structural, metabolic, and functional status of erythrocytes in patients with head and neck tumors].
The structure, metabolic status, and functional properties of erythrocytes in patients with stage III-IV head and neck tumors in the course of antineoplastic cytostatic chemotherapy (platidiam, 5-fluorouracil, methotrexate) were studied. In the course of this treatment, disorders of the morphology and functional state of erythrocytes (reduced dry mass, decreased content of sulfohydryl grups and lipoproteins, increased number of transformed cells and the cells with violated ultrastructure, enhanced reversible aggregation of erythrocytes) were retained or became more pronounced.
Stepovaia
E A
EA
Novitskiĭ
V V
VV
Gol'dberg
V E
VE
Riazantseva
N V
NV
Tkachenko
S B
SB
Kolosova
M V
MV
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D004912:Erythrocytes / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged
D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate