Virus-like particles as vaccines and vessels for the delivery of small molecules.
Virus-like particles (VLPs) structurally mimic the viral capsid and have therefore been extensively, and quite successfully, used as vaccine and viral serology reagents. The ability of VLPs to include nucleic acids and small molecules has also made them novel vessels for gene and drug delivery. The regular, repetitive surface of VLPs has been exploited as a template for nanoscale synthesis. Recent progress has been made in the development of several virus models.
Garcea
Robert L
RL
Section of Pediatric Hematology/Oncology, University of Colorado School of Medicine, Denver, Colorado 80262, USA.
Gissmann
Lutz
L
D000818:Animals; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D006801:Humans; D014612:Vaccines; D014780:Viruses
D014612:Vaccines