[Joint destruction and matrix metalloproteinases--regulation by pharmacologic inhibitors and growth factors].
Matrix metalloproteinase (MMP) plays an important role in degradation of cartilage matrix. The expression of MMPs in cartilage or syovial membrane was increased in osteoarthritis or rheumatoid arthritis. We summarized the regulation mechanism of MMP production, and described pharmacologic inhibitors such as non steroidal anti-inflammatory drugs, steroid and growth factors, which might be useful to prevention of joint destruction.
Matsumoto
Tomoko
T
Department of Orthopedic Surgery, Nagasaki University, School of Medicine.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D002358:Cartilage, Articular / Q000201:enzymology / Q000378:metabolism; D003864:Depression, Chemical; D003907:Dexamethasone / Q000494:pharmacology* / Q000627:therapeutic use; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology* / Q000627:therapeutic use; D020782:Matrix Metalloproteinases / Q000096:biosynthesis / Q000502:physiology*; D010003:Osteoarthritis / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D013583:Synovial Membrane / Q000201:enzymology; D016212:Transforming Growth Factor beta / Q000502:physiology* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016212:Transforming Growth Factor beta; D007334:Insulin-Like Growth Factor I; D003907:Dexamethasone; D020782:Matrix Metalloproteinases