title: Effect of aqueous leaf extract of Irvingia gabonensis on gastrointestinal tract in rodents.
abstract: Effect of the aqueous leaf extract of I. gabonensis on the gastrointestinal tract was investigated on isolated rabbit jejunum, guinea pig ileum, gastrointestinal motility, castor oil-induced diarrhoea in mice and castor oil-induced fluid accumulation in rats. The results showed that the extract exhibited a concentration-dependent relaxation of spontaneous pendular movement of isolated rabbit jejunum and guinea pig ileum, and attenuated both acetylcholine-induced contraction of rabbit jejunum and histamine-induced contraction of guinea pig ileum. The extract (100, 200 and 400 mg/kg) also caused a significant dose-dependent decrease of gastrointestinal motility in mice (40.12, 39.45 and 37.45%), intestinal fluid accumulation in rats (71.43, 81.63 and 83.27%), and remarkably protected mice against castor oil-induced diarrhoea [58.33, 75 and 91.67% (Di Carlo score)] respectively. Preliminary phytochemical screening of the aqueous leaf extract of I. gabonensis revealed the presence of saponins, tannins, phenols and phlobatanins.
authors.affiliation: Department of Chemistry, University of Maiduguri, Borno State, Nigeria.
authors.forename: F
authors.initials: F
authors.lastname: Abdulrahman
authors.forename: I S
authors.initials: IS
authors.lastname: Inyang
authors.forename: J
authors.initials: J
authors.lastname: Abbah
authors.forename: L
authors.initials: L
authors.lastname: Binda
authors.forename: S
authors.initials: S
authors.lastname: Amos
authors.forename: K
authors.initials: K
authors.lastname: Gamaniel
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D002482:Cellulose / Q000494:pharmacology*; D003967:Diarrhea / Q000188:drug therapy; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D029641:Simaroubaceae
chemical_list: D000930:Antidiarrheals; D010936:Plant Extracts; C051375:dikanut; D002482:Cellulose