Signs of rapidly progressive dementia in a case of intravascular lymphomatosis.
Intravascular lymphomatosis (IVL), a rare type of non-Hodgkin's lymphoma, is an uncommon cause of progressive dementia, usually followed by death within a few months of onset of clinical disease. Often this aggressive tumor is only diagnosed at autopsy, because of misleading clinical features mimicking a broad spectrum of syndromes and the absence of circulating lympoma cells in the blood, bone marrow or cerebrospinal fluid in many cases. Here we present IVL in a 78-year-old woman with findings leading to the clinical diagnosis of vascular dementia with sudden beginning and positive 14-3-3 protein in the CSF, commonly reported in Creutzfeldt-Jakob disease (CJD).
Albrecht
R
R
Institute of Neuropathology, LMU Munich, 81377 Munich, Germany.
Krebs
B
B
Reusche
E
E
Nagel
M
M
Lencer
R
R
Kretzschmar
H A
HA
D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid; D000368:Aged; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000473:pathology / Q000523:psychology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology / Q000523:psychology*; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis / Q000473:pathology
D048948:14-3-3 Proteins