Ribosome synthesis meets the cell cycle.
A large number of ribosome synthesis factors have been identified using proteomic analyses in yeast. The patterns of RNA and protein co-precipitation suggest that ribosome synthesis does not proceed via a linear progression of successive steps. Recent analyses have identified several interactions between factors clearly implicated in ribosome synthesis and specific steps in the cell division cycle. The intersections between these pathways were not anticipated, but potential explanations for their existence can be advanced.
Dez
Christophe
C
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK.
Tollervey
David
D
D002453:Cell Cycle / Q000502:physiology*; D015966:Gene Expression Regulation, Fungal; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
D012269:Ribosomal Proteins; D029701:Saccharomyces cerevisiae Proteins