The antimotility action of a trifluoromethyl ketone on some gram-negative bacteria.
The inhibition of bacterial motility was studied by a trifluoro methyl ketone derivative on two Escherichia coli strains (wild strain having a proton pump system and the proton pump-deficient mutant strain) and two Helicobacter pylori strains (clarithromycin susceptible and clarithromycin resistant). Evidence is presented of the inhibitory action of 1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone (TF18) on the proton motive forces of the two bacterial strains by affecting the action of biological motor and proton efflux in the membranes. The swimming, the forward motion was more sensitive than the vibration or tumbling to the inhibition. We suppose that the inhibiton of bacterial motility is related to the virulence of bacteria: consequently the pathogenicity can be reduced in the presence of TF18.
Spengler
Gabriella
G
Departament of Medical Microbiology and Immunobiology, Albert Szent-Györgyi Medical Centre, Faculty of Medicine, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary.
Molnár
Annamária
A
Klausz
G
G
Mándi
Yvette
Y
Kawase
M
M
Motohashi
N
N
Molnár
J
J
D000890:Anti-Infective Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000502:physiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000502:physiology; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology*; D009068:Movement / Q000187:drug effects; D054328:Proton Pump Inhibitors
D000890:Anti-Infective Agents; D007659:Ketones; D054328:Proton Pump Inhibitors