title: [Study on association between aldosterone synthase gene polymorphism and the left ventricular structure and function of patients with dilated cardiomyopathy in China].
abstract: OBJECTIVE
  To investigate the association between a -344 C/T polymorphism of aldosterone synthase gene (CYP11B2) and the left ventricular structure and function of patients with dilated cardiomyopathy (DCM) in China.
  
  
  METHODS
  Eighty-nine patients with DCM were genotyped by PCR-RFLP, and were divided into TT, TC, CC and TT+CC four groups by their genotypes, respectively. Left ventricular structure and function were assessed with echocardiography.
  
  
  RESULTS
  There was no significant difference between four groups in left ventricular diameters, mass and ejection fraction in patients with DCM.
  
  
  CONCLUSIONS
  The data were not in favor of a significant association between the aldosterone synthase gene CYP11B2 and the left ventricular structure and function in patients with DCM.
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: Li
authors.initials: L
authors.lastname: Rao
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Yu-ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Ying-bi
authors.initials: YB
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002311:Cardiomyopathy, Dilated / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D013318:Stroke Volume; D016277:Ventricular Function, Left
chemical_list: D019405:Cytochrome P-450 CYP11B2