title: Elective neck dissection and survival in patients with squamous cell carcinoma of the oral cavity and oropharynx.
abstract: OBJECTIVE
  The utility of elective neck dissection in the management of patients with oral cavity and oropharyngeal cancer who present without neck metastases remains controversial. The study addressed the question of whether elective neck dissection improves regional control and survival in patients with squamous cell carcinoma of the oral cavity and oropharynx presenting with T1/T2 node-negative disease.
  
  
  METHODS
  A nonrandomized, uncontrolled retrospective chart review.
  
  
  METHODS
  A nonrandomized, uncontrolled retrospective chart review was performed. Resection of the primary tumor was performed in all patients. The neck was observed in one group, and elective neck dissection was performed for patients in another group.
  
  
  RESULTS
  The study data indicated that elective neck dissection significantly improves regional control and regional recurrence-free survival. Elective neck dissection when compared with observation of the neck did not improve overall survival.
  
  
  CONCLUSIONS
  Elective neck dissection reduces regional recurrence and may extend disease-free survival.
authors.affiliation: Department of Otolaryngology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, USA. duvvuriu@upmc.edu
authors.forename: Umamaheswar
authors.initials: U
authors.lastname: Duvvuri
authors.forename: Alfred A
authors.initials: AA
authors.lastname: Simental
authors.forename: Gina
authors.initials: G
authors.lastname: D'Angelo
authors.forename: Jonas T
authors.initials: JT
authors.lastname: Johnson
authors.forename: Robert L
authors.initials: RL
authors.lastname: Ferris
authors.forename: William
authors.initials: W
authors.lastname: Gooding
authors.forename: Eugene N
authors.initials: EN
authors.lastname: Myers
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D002423:Cause of Death; D015331:Cohort Studies; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D037981:Neck Dissection / Q000379:methods* / Q000401:mortality; D009959:Oropharyngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D011336:Probability; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome