Cell size relations for sonolysis.
The occurrence of cell lysis following exposure to ultrasound (US) has been well documented; the specifics of the mechanistic process(es) involved have proven to be difficult to characterize. There appear to be two major mechanisms of US-induced cell lysis in vitro, acoustic cavitation and bubble transport. Both involve shear forces. Earlier research showed that the size of oil droplets was a crucial factor in their rupture by shear forces; the greater the size the greater the rupture per unit shear force. Here we find further support (Miller et al. 2000, 2001a, 2003a; Miller and Battaglia 2003; Abramwocz et al. 2003) that, under a number of experimental US conditions causing hemolysis in vitro, cell volume (i.e., size) is an apparently critical factor.
Miller
Morton W
MW
Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA. Morton_Miller@urmc.rochester.edu
D000818:Animals; D002417:Cattle; D048429:Cell Size; D004909:Erythrocyte Indices / Q000502:physiology; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D051379:Mice; D011817:Rabbits; D013997:Time Factors; D014465:Ultrasonics