[The tissue-specific methylation of human-specific endogenous retroviral long terminal repeats].
A possible involvement of retroelements in the epigenetic regulation of human gene expression was considered by the example of methylation of long terminal repeats (LTRs) of the human endogenous retrovirus family K (HERV-K). The methylation status of six HERV-K LTRs was determined in various gene-enriched regions of the human genome. The methylation of four LTRs was shown to be tissue-specific. Our results correlated with published data on the tissue-specific changes in the expression level of human genes adjacent to the LTRs under study. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // www.maik.ru.
Khodosevich
K V
KV
Lebedev
Iu B
IuB
Sverdlov
E D
ED
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000235:genetics; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D019175:DNA Methylation; D019003:Deoxyribonuclease HpaII / Q000235:genetics / Q000378:metabolism; D042967:Electron Transport Complex I; D020077:Endogenous Retroviruses / Q000235:genetics*; D005786:Gene Expression Regulation; D023061:Gene Order; D006801:Humans; D008099:Liver / Q000502:physiology / Q000821:virology; D008168:Lung / Q000502:physiology / Q000821:virology; D008198:Lymph Nodes / Q000502:physiology / Q000821:virology; D009245:NADH Dehydrogenase; D009928:Organ Specificity; D011506:Proteins / Q000235:genetics; D020079:Terminal Repeat Sequences
C112232:NDUFV1 protein, human; D011506:Proteins; D009245:NADH Dehydrogenase; D019003:Deoxyribonuclease HpaII; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D042967:Electron Transport Complex I