Heterosexual transmission of multiple highly conserved viral variants in HIV-1 subtype C-infected seronegative women.
Viral population diversity was assessed in samples collected from five HIV-infected women who were RNA positive and antibody negative. Similar to studies in men, highly conserved viral variants were detected (mean nucleotide diversity of 0.11% for p17p24, 0.32% for C2C3). In two individuals diversity was uncharacteristically lower in env C2C3 than in gag pl7p24, suggesting selection in env at this very early stage of infection.
Rademeyer
Cecilia
C
Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, University of Cape Town, Observatory 7925, Cape Town, South Africa.
van Harmelen
Joanne H
JH
Ramjee
Gita
G
Karim
Salim Sabdool
SS
Williamson
Carolyn
C
D002999:Clone Cells; D005260:Female; D015752:Genes, env / Q000235:genetics*; D015750:Genes, gag / Q000235:genetics*; D014644:Genetic Variation; D015658:HIV Infections / Q000635:transmission*; D015497:HIV-1; D020010:Heterosexuality; D006801:Humans; D012189:Retrospective Studies; D011477:Sex Work