In vitro activities of OPT-80 and comparator drugs against intestinal bacteria.
The activities of OPT-80 against 453 intestinal bacteria were compared with those of seven other drugs. OPT-80 showed good activity against most clostridia, staphylococci, and enterococci, but streptococci, aerobic and facultative gram-negative rods, anaerobic gram-negative rods, and Clostridium ramosum were resistant. Poor activity against anaerobic gram-negative rods may maintain colonization resistance.
Finegold
Sydney M
SM
Medical Service, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA. sidfinegol@aol.com
Molitoris
Denise
D
Vaisanen
Marja-Liisa
ML
Song
Yuli
Y
Liu
Chengxu
C
Bolaños
Mauricio
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D005243:Feces / Q000382:microbiology; D006027:Glycosides / Q000494:pharmacology*; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D006027:Glycosides; C487655:OPT 80