Household survey of dengue infection in central Brazil: spatial point pattern analysis and risk factors assessment.
Urban dengue fever is now considered a major public health threat in most American countries. A household survey was conducted in the city of Goiania in central Brazil in 2001 to assess prevalence of dengue infection and individual and area-based risk factors. Spatial point pattern analysis was performed using the dual Kernel method. A total of 1,610 households were surveyed; 1,585 individuals more than five years old had blood and data collected. Sera were tested for IgM/IgG antibodies by an enzyme-linked immunoassay. Area-based indicators derived from census data were linked to geocoded residential address. The seroprevalence of dengue was 29.5% and the estimate prevalence surface reached 50% in the outskirts areas. The risk of infection was significantly associated with older age (P < 0.01), low education (odds ratio [OR] = 3.45, 95% confidence interval [CI] = 1.82-6.55), and low income (OR = 1.32, 95% CI = 1.02-1.71) in multivariate analysis. This study highlighted the heterogeneity of dengue transmission within the city and can assist in spatial targeting control interventions.
Siqueira
João B
JB
Brazilian Ministry of Health, 7o Andra Sala 715 70 070, 040 Brasilia, DF, Brazil.
Martelli
Celina M T
CM
Maciel
Ivan J
IJ
Oliveira
Renato M
RM
Ribeiro
Maria G
MG
Amorim
Flúvia P
FP
Moreira
Bruno C
BC
Cardoso
Divina D P
DD
Souza
Wayner V
WV
Andrade
Ana Lúcia S S
AL
D000293:Adolescent; D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D009033:Culicidae; D003710:Demography; D003715:Dengue / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D003716:Dengue Virus / Q000276:immunology / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007303:Insect Vectors; D008297:Male; D008875:Middle Aged; D012111:Residence Characteristics; D012307:Risk Factors; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral