title: Susceptibility of Leptospira serovars to antimalarial agents.
abstract: Leptospirosis has recently been described to cause concomitant infection with malaria. Only doxycycline has proven to have chemoprophylactic and therapeutic efficacy for both malaria and leptospirosis. To assess whether other traditional antimalarial agents have antileptospiral activity, we performed broth microdilution susceptibility testing of 16 Leptospira serovars (6 species/14 serogroups) to various agents. Artemisinin, atovaquone, chloroquine, mefloquine, primaquine, proguanil, pyrimethamine, sulfadoxine, quinine, quinidine, and combinations of atovaquone/proguanil and pyrimethamine/sulfadoxine all had a 90% minimum inhibitory concentration (MIC(90)) > 25 microg/mL (the upper limit of testing). The only agents identified with the potential to treat both infections other than doxycycline (MIC(90) = 1.56 microg/mL) were azithromycin (MIC(90) = 0.002 microg/mL) and clindamycin (MIC(90) = 0.2 microg/mL).
authors.affiliation: Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA. Clinton.Murray@amedd.army.mil
authors.forename: Clinton K
authors.initials: CK
authors.lastname: Murray
authors.forename: Michael W
authors.initials: MW
authors.lastname: Ellis
authors.forename: Duane R
authors.initials: DR
authors.lastname: Hospenthal
mesh_terms: D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D015897:Comorbidity; D006801:Humans; D007919:Leptospira / Q000145:classification / Q000187:drug effects*; D007922:Leptospirosis / Q000150:complications / Q000188:drug therapy; D008288:Malaria / Q000150:complications / Q000188:drug therapy; D008826:Microbial Sensitivity Tests
chemical_list: D000962:Antimalarials