Novel intramolecular rearrangement leading to the synthesis of biheterocyclic indole-benzoimidazole derivatives on solid phase.
[reaction: see text] A novel intramolecular SNAr rearrangement observed during the S-alkylation of benzoimidazole-2-thione with alpha-haloacetophenone is reported. The rearrangement led to the formation of a new benzoimidazole-based intermediate, which is further utilized for the generation of a new biheterocyclic indole-benzimidazole derivatives with a two-point diversity.
Roy
Abhijeet Deb
AD
Division of SAIF, Central Drug Research Institute, Lucknow 226001, India.
Sharma
Sunil
S
Grover
Rajesh Kumar
RK
Kundu
Bijoy
B
Roy
Raja
R