Primary vaginal adenosarcoma with sarcomatous overgrowth.
BACKGROUND
Primary vaginal adenosarcomas are extremely rare, and typical adenosarcomas are of low malignancy. However, aggressive forms with sarcomatous overgrowth have been reported, those appear to have a poor prognosis.


METHODS
A 52-year-old woman who had undergone prior surgery for uterine leiomyoma and an ovarian cyst (total abdominal hysterectomy and left salpingo-oophorectomy) presented 10 years later with a rapidly enlarging tumor arising from the vaginal cuff. Repetitive biopsy samples revealed a mixture of benign epithelial gland and malignant stromal components with periglandular stromal hypercellularity and sarcomatous overgrowth. A histological diagnosis of mullerian adenocarcinoma was made. The patient died from recurrent disease 9 months after surgery.


CONCLUSIONS
Regardless of primary focus, adenosarcoma with sarcomatous overgrowth is associated with postoperative recurrence and a fatal outcome.
Toyoshima
Masafumi
M
Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba, Sendai 980-8574, Japan. m-toyo@mail.tains.tohoku.ac.jp
Akahira
Jun-ichi
J
Moriya
Takuya
T
Hayakawa
Seiichirou
S
Yaegashi
Nobuo
N
D018195:Adenosarcoma / Q000188:drug therapy / Q000473:pathology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology*; D010052:Ovariectomy; D014594:Uterine Neoplasms / Q000601:surgery; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000473:pathology*