A subinhibitory concentration of clarithromycin inhibits Mycobacterium avium biofilm formation.
Mycobacterium avium causes disseminated infection in immunosuppressed individuals and lung infection in patients with chronic lung diseases. M. avium forms biofilm in the environment and possibly in human airways. Antibiotics with activity against the bacterium could inhibit biofilm formation. Clarithromycin inhibits biofilm formation but has no activity against established biofilm.
Carter
George
G
Kuzell Institute, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Young
Lowell S
LS
Bermudez
Luiz E
LE
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology; D017963:Azithromycin / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects*; D017291:Clarithromycin / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D000077266:Moxifloxacin; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D015270:Mycobacterium avium-intracellulare Infection / Q000382:microbiology; D011804:Quinolines / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D017963:Azithromycin; D017291:Clarithromycin; D000077266:Moxifloxacin