title: Absorption of myo-inositol hexakisphosphate (InsP6) through the skin: study of the matrix effects. mechanism of phytate topical absorption.
abstract: Myo-inositol hexakisphosphate (InsP6, phytate) is a molecule to which diverse beneficial properties have been attributed. Some of these properties are related to its dermatological use as discolouring agent, on preventing calcinosis cutis or due to its important role on premature aging. Other studies also seem to demonstrate a capacity of InsP6 to inhibit skin cancer. In this paper, the effect of the vehicle of topical administration of phytate is studied, using four groups of male Wistar rats (n = 6) fed with an InsP6 defficient diet and treated with a hydrophyl gel or an O/W moisturizing cream with two different concentrations of InsP6. Due to the correlation between InsP6 absorption and its urinary excretion, these last values were used to evaluate this process. It was found that phytate was absorbed through the skin using both a gel or a cream, demonstrating that its absorption is independent on the matrix used for topical treatment. However, urinary InsP6 values were slightly higher when using the gel, but in all cases values were much higher than those found with oral InsP6 treatment, due to the formation of insoluble species in the gastrointestinal tract when InsP6 is administered orally.
authors.affiliation: Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research (IUNICS), University of Balearic Islands, Palma of Mallorca, Spain. fgrases@uib.es <fgrases@uib.es>
authors.forename: Felix
authors.initials: F
authors.lastname: Grases
authors.forename: Bernat
authors.initials: B
authors.lastname: Isern
authors.forename: Joan
authors.initials: J
authors.lastname: Perelló
authors.forename: Pilar
authors.initials: P
authors.lastname: Sanchis
authors.forename: Rafel M
authors.initials: RM
authors.lastname: Prieto
mesh_terms: D000287:Administration, Topical; D000375:Aging; D000818:Animals; D002114:Calcinosis / Q000378:metabolism; D003880:Dermatology / Q000379:methods; D041981:Gastrointestinal Tract / Q000473:pathology; D008297:Male; D010833:Phytic Acid / Q000378:metabolism* / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism*; D012869:Skin Absorption
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; C068271:inositol hexakisphosphate receptor; D010833:Phytic Acid