[Genetic analysis of X-chromosome neurodegenerative mutants of Drosophila melanogaster induced by ethyl methansulfonate and nitrosoethylurea].
In a series of Drosophila mutants with changes in the brain structure, some characters (reduced life span, behavioral changes, and neuronal loss in various brain regions) resemble symptoms observed in human patients with neurodegenerative diseases. In addition, similar specific phenotypes shared by different species suggest that common mechanisms underlie degeneration of their nerve cell. This study reports the results of a genetic analysis of new X-chromosome mutants with neurodegenerative changes in brain structure, which were induced by chemical mutagenesis. According to complementation test, all mutants were divided into three complementation groups, in which the life span and dynamics of neurodegenerative changes were studied. The life span of Drosophila melanogaster flies was found to depend on the state of their nervous system.
Shcherbata
G R
GR
Matiĭtsiv
N P
NP
Chernik
Ia I
IaI
Iatsenko
A S
AS
Radysh
V V
VV
Kucherenko
M M
MM
Maksimiv
D V
DV
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002874:Chromosome Mapping; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics*; D005020:Ethyl Methanesulfonate / Q000633:toxicity*; D005038:Ethylnitrosourea / Q000633:toxicity*; D005260:Female; D017344:Genes, Insect / Q000187:drug effects; D008136:Longevity / Q000235:genetics; D008297:Male; D009153:Mutagens / Q000633:toxicity; D009154:Mutation; D009410:Nerve Degeneration / Q000139:chemically induced / Q000235:genetics / Q000473:pathology; D014960:X Chromosome / Q000235:genetics*
D009153:Mutagens; D005020:Ethyl Methanesulfonate; D005038:Ethylnitrosourea