title: Pathways regulating lens induction in the mouse.
abstract: For more than a century, the lens has provided a relatively simple structure in which to study developmental mechanisms. Lens induction, where adjacent tissues signal the cell fate changes that result in lens formation, have been of particular interest. Embryological manipulations advancing our understanding have included the Spemann optic rudiment ablation experiments, optic vesicle transplantations as well as more contemporary work employing lineage tracers. All this has revealed that lens induction signaling is a multi-stage process involving multiple tissue interactions. More recently, molecular genetic techniques have been applied to an analysis of lens induction. This has led to the identification of signaling pathways required for lens induction and early lens development. These include the bone morphogenetic protein (Bmp) signaling pathways where Bmp4 and Bmp7 have been implicated. Though no fibroblast growth factor (Fgf) ligand has been implicated at present, the Fgf signaling pathway clearly has an important role. A series of transcription factors involved in early lens development have also been identified. These include Pax6, the Meis transcription factors, Six3, Mab21l1, FoxE3, Prox1 and Sox2. Importantly, analysis has indicated how these elements of the lens induction pathway are related and has defined genetic models to describe the process. It is a future challenge to test existing genetic models and to extend them to incorporate the tissue interactions mediated by the molecules involved. Given the complexity of this and many other developmental processes, a second century of analysis will be welcome.
authors.affiliation: Division of Developmental Biology and Department of Ophthalmology, Children's Hospital Research Foundation, Cincinnati, OH 45229, USA. richard.lang@cchmc.org
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lang
mesh_terms: D000818:Animals; D019521:Body Patterning; D055415:Bone Morphogenetic Protein 4; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D002454:Cell Differentiation; D019070:Cell Lineage; D004268:DNA-Binding Proteins / Q000378:metabolism; D004627:Embryonic Induction; D005123:Eye / Q000196:embryology*; D005136:Eye Proteins / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D024002:HMGB Proteins / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism; D007908:Lens, Crystalline / Q000196:embryology* / Q000378:metabolism; D008024:Ligands; D051379:Mice; D008954:Models, Biological; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D010766:Phosphorylation; D012097:Repressor Proteins / Q000378:metabolism; D055748:SOXB1 Transcription Factors; D015398:Signal Transduction; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: C525810:Bmp4 protein, mouse; D055415:Bone Morphogenetic Protein 4; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D004268:DNA-Binding Proteins; D005136:Eye Proteins; D024002:HMGB Proteins; D018398:Homeodomain Proteins; D008024:Ligands; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; C000605732:Pax6 protein, mouse; D012097:Repressor Proteins; D055748:SOXB1 Transcription Factors; C527783:Sox2 protein, mouse; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors