CFD modeling of blood flow following coil embolization of aneurysms.
In case of coil embolization of a giant or a multilobular aneurysm, it is difficult to fill an aneurysm sac completely with coils, therefore, partial blocking of an aneurysm sac is inevitable. Blood flow characteristics, which may influence embolization process of an aneurysm, are affected by the locations of coils for partially blocked aneurysms. Blood flow fields inside an aneurysm are also influenced by the geometry of a parent vessel. In order to suggest the coil locations effective for aneurysm embolization, the blood flow fields of lateral aneurysm models were analyzed for different coil locations and parent vessel geometries. Flow rate into an aneurysm sac from a parent vessel (inflow rate) and wall shear stress were also calculated. Inflow rates were smaller and low wall shear regions were larger in the distal neck blocked model comparing to the dome blocked models. In the distal neck blocked model, inflow volume was smaller by 31% (straight parent vessel model) and 34% (curved parent vessel model) comparing to other models. The time averaged values of normalized low wall shear regions were 4% and 12% greater in the distal neck blocked models with a straight and a curved parent vessel, respectively. Since smaller inflow and low wall shear stress provide hemodynamic environment promoting thrombus embolization, distal neck should be the effective coil location for aneurysm embolization.
Byun
Hong Sik
HS
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Rhee
Kyehan
K
D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000503:physiopathology; D003198:Computer Simulation; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology* / Q000628:therapy*; D008955:Models, Cardiovascular; D019919:Prosthesis Implantation / Q000379:methods; D033081:Shear Strength; D016896:Treatment Outcome