Synthesis and antifungal activity of 5,8-quinazolinedione derivatives modified at positions 6 and 7.
5,8-Quinazolinediones modified at positions 6 and 7 were synthesized and tested for in vitro antifungal activities against Candida species and Aspergillus niger. Most of 5,8-quinazolinediones 3-5 generally exhibited potent antifungal activity. 6-Arylamino-7-chloro-5,8-quinazolinediones (3) generally showed more potent antifungal activity than 7-arylthio-5,8-quinzolinediones (4) and 6,7-bis-(arylthio)-5,8-quinazolinediones (5).
Ryu
Chung-Kyu
CK
College of Pharmacy, Ewha Womans University, Sodaemun-Ku, Seoul 120-750, Korea. ckryu@mm.ewha.ac.kr
Shim
Ju-Yeon
JY
Yi
You-Jin
YJ
Choi
Ik Hwa
IH
Chae
Mi Jin
MJ
Han
Ja-Young
JY
Jung
Ok-Jai
OJ
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D002855:Chromatography, Thin Layer; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship
C497733:5,8-quinazolinedione; D000935:Antifungal Agents; D007202:Indicators and Reagents; D011799:Quinazolines