title: Effect of alpha-tocopherol supplementation on blood pressure and lipidic profile in streptozotocin-induced diabetes mellitus in spontaneously hypertensive rats.
abstract: BACKGROUND
  Antioxidants has been utilized to prevent oxidative damage in diabetes and hypertensive diseases. The current study evaluated the effect of alpha-tocopherol supplementation on blood pressure and the lipid profile in streptozotocin-induced diabetes mellitus in spontaneously hypertensive rats (SHR).
  
  
  METHODS
  The systolic blood pressure and total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were measured in SHR-diabetes induced.
  
  
  RESULTS
  Treatment with alpha-tocopherol (vitamin E) led to a decrease on systolic blood pressure and showed an increase of HDL-cholesterol and a decrease of LDL-cholesterol, but the concentrations of triglycerides and total cholesterol were not changed.
  
  
  CONCLUSIONS
  The vitamin E was able to modulate the blood pressure and the lipidic profile as well, and therefore can be considered as an alternative treatment of lipid disorder found on diabetes and hypertension diseases.
authors.affiliation: Laboratory of Nutritional Investigation and Degenerative-Chronic Diseases, Federal University of Rio de Janeiro State, Brazil.
authors.forename: Virginia Alice
authors.initials: VA
authors.lastname: Vieira da Costa
authors.forename: Lucia Marques
authors.initials: LM
authors.lastname: Vianna
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000503:physiopathology*; D004032:Diet; D019587:Dietary Supplements; D006973:Hypertension / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D008055:Lipids / Q000097:blood*; D051381:Rats; D011918:Rats, Inbred SHR; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D014810:Vitamin E; D002784:Cholesterol