Synthesis and in vitro study of novel Mannich bases as antibacterial agents.
A series of novel Mannich bases derived from 5-chloro-2-methoxybenzamide and sulfonamides/amines have been synthesised and the antibacterial activities were evaluated against various Gram positive and Gram negative strains of bacteria. Some of the synthesized compounds showed superior in vitro activities as compared to their parent sulfonamides.
Joshi
Sheela
S
School of Chemical Sciences, Devi Ahilya Vishwavidyalaya, Takshila Campus, Khandwa Road, Indore, Madhya Pradesh (M.P.), India. spjoshi11@rediffmail.com
Khosla
Navita
N
Khare
Deepak
D
Sharda
Rakesh
R
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D013057:Spectrum Analysis / Q000379:methods
D000900:Anti-Bacterial Agents