Synthesis of a shark repellent peptide toxin, Pardaxin (16-33) on a highly flexible polymer support: CLPSER.
A high swelling resin, CLPSER has been developed and utilized for the solid phase synthesis of Pardaxin, which is an 18-residue peptide. The resin was characterized by gel phase (13)C NMR, IR and SEM. The utility of the new polymer support in polypeptide synthesis was further established by the comparative synthesis of pardaxin with commercially available Merrifield resin. The MALDI TOF MS, amino acid analysis and the HPLC revealed the superior quality of CLPSER.
Kumar
G S Vinod
GS
Rajiv Gandhi Center for Biotechnology, Poojappura, Thiruvananthapuram, 695014 Kerala, India.
Leena
S
S
Kumar
K Santhosh
KS
D005397:Fish Venoms / Q000138:chemical synthesis*; D010446:Peptide Fragments / Q000138:chemical synthesis*; D012117:Resins, Synthetic
D005397:Fish Venoms; D010446:Peptide Fragments; D012117:Resins, Synthetic; C017603:pardaxin