Co-occurrence of Wilson's disease and glioblastoma multiforme--is it a chance association?
We report a patient with glioblastoma multiforme who was subsequently diagnosed to have Wilson's disease. Immunohistochemical studies of the tumor revealed high (> 60%) labeling index for p53 and Rb retinoblastoma protein. Whether this association is like the co-occurrence of retinoblastoma and Wilson's disease due to possible somatic mutation in chromosome 13 needs to be explored.
Sinha
S
S
Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Prashanth
L K
LK
Mahadevan
A
A
Satish
S
S
Ravishankar
S
S
Arunodaya
G R
GR
Taly
A B
AB
Shankar
S K
SK
D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D005909:Glioblastoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006527:Hepatolenticular Degeneration / Q000150:complications*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D016160:Retinoblastoma Protein / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53