Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?
Cyclin-dependent kinase inhibitors (CKIs) are well known inhibitors of cell proliferation. Their activity is disrupted in many tumour types. Recent studies show that some of these proteins have interesting alternative functions, acting in the cytoplasm to regulate Rho signalling and thereby controlling cytoskeletal organization and cell migration. The upregulation of CKIs in the cytoplasm of many cancer cells indicates that although loss of nuclear CKIs is important for cancer cell proliferation, gain of cytoplasmic CKI function might be involved in tumour invasion and metastasis.
Besson
Arnaud
A
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Division of Basic Science, Seattle, Washington 98109, USA.
Assoian
Richard K
RK
Roberts
James M
JM
D002455:Cell Division; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D003599:Cytoskeleton / Q000187:drug effects / Q000473:pathology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology*; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D004791:Enzyme Inhibitors; D018844:Cyclin-Dependent Kinases; D020741:rho GTP-Binding Proteins