Benzoic acid derivatives from Piper species and their fungitoxic activity against Cladosporium cladosporioides and C. sphaerospermum.
Piper crassinervium, P. aduncum, P. hostmannianum, and P. gaudichaudianum contain the new benzoic acid derivatives crassinervic acid (1), aduncumene (8), hostmaniane (18), and gaudichaudianic acid (20), respectively, as major secondary metabolites. Additionally, 19 known compounds such as benzoic acids, chromenes, and flavonoids were isolated and identified. The antifungal activity of these compounds was evaluated by bioautographic TLC assay against Cladosporium cladosporioides and C. sphaerospermum.
Lago
João Henrique G
JH
Instituto de Química, Universidade de São Paulo, C.P. 26077-05599-970, São Paulo, SP, Brazil.
Ramos
Clécio Sousa
CS
Casanova
Diego Campos C
DC
Morandim
Andreia de A
Ade A
Bergamo
Debora Cristina B
DC
Cavalheiro
Alberto J
AJ
Bolzani
Vanderlan da S
Vda S
Furlan
Maysa
M
Guimarães
Elsie F
EF
Young
Maria Claudia M
MC
Kato
Massuo J
MJ
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D002855:Chromatography, Thin Layer; D002963:Cladosporium / Q000187:drug effects*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031701:Piper / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000935:Antifungal Agents; D001565:Benzoates; C494627:aduncumene; C494626:crassinervic acid; C494629:gaudichaudianic acid; C494628:hostmaniane