[Reaction of the physiological IOP in rabbits after application of the latanoprost (Xalatan) and amino acid L-arginine HCl mixture].
Authors present results of series of experiments focused to influence the IOP by antiglaucomatics in rabbits (New Zealand White) with physiological IOP. Adding of the 10% amino acid L-arginine x HCl to the 0.005% Xalatan eye drops intensifies activity of antiglaucomatics resulting in 9.5% average reduction of the IOP in a four-hour experiments (with maximum in 15th min.--19.3%), compared with application of both substances alone. Size of the pupil was not affected. Based on our experimental results we assume that the increased activity of the 0.005% Xalatan mixture with 10% amino acid L-arginine x HCl created a new complete metabolite--"bio-antiglaucomaticum". According to our observations this metabolite caused increase of the uveo-scleral outflow leading to the striking reduction of the physiological IOP in rabbits.
Veselovský
J
J
PriF UK, Bratislava, SR.
Oláh
Z
Z
Veselá
A
A
Gressnerová
S
S
D000818:Animals; D001120:Arginine / Q000008:administration & dosage* / Q000494:pharmacology; D004338:Drug Combinations; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage* / Q000494:pharmacology; D011817:Rabbits
D004338:Drug Combinations; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D001120:Arginine