Chemokine polymorphisms: candidates for MS susceptibility and disease course.
As the basic understanding of the autoimmune inflammatory response in MS expands, polymorphic genes involved in this response become candidates for genetic susceptibility or resistance to the disease. Recent advances in the identification of chemokines and their receptors have provided evidence for their consideration as candidate loci in the aetiology of MS. This is due to the key role chemokines play in the physiology of inflammation and regulation of central nervous system trafficking across the blood-brain barrier, and their exploitation by certain micro-organisms to initiate infection.
Achiron
A
A
Multiple Sclerosis Centre, Sheba Medical Centre, Tel-Hashomer, Israel. achqzron@sheba.health.gov.il
D018925:Chemokines / Q000235:genetics* / Q000378:metabolism*; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics* / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics*; D019707:Receptors, Chemokine / Q000235:genetics
D018925:Chemokines; D019707:Receptors, Chemokine