title: Evaluation of genetic substructure in the Irish Study of High-Density Schizophrenia Families.
abstract: The presence of genetic substructure has the potential to diminish the chances of detecting a linkage signal. Using a Markov chain Monte Carlo procedure developed by Pritchard and colleagues and implemented in the program STRUCTURE, we evaluated the evidence for genetic substructure using genotypes from 37 microsatellite markers in affected individuals selected at random from 263 multiplex families in the Irish Study of High-Density Schizophrenia Families. We found no evidence for the presence of genetic substructure in this sample.
authors.affiliation: University of North Carolina at Chapel Hill, Department of Genetics, 27599-7264, USA. pfsulliv@med.unc.edu
authors.forename: Patrick F
authors.initials: PF
authors.lastname: Sullivan
authors.forename: Dermot
authors.initials: D
authors.lastname: Walsh
authors.forename: F Anthony
authors.initials: FA
authors.lastname: O'Neill
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Kendler
mesh_terms: D005190:Family; D005260:Female; D005838:Genotype; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D018895:Microsatellite Repeats; D012559:Schizophrenia / Q000453:epidemiology* / Q000235:genetics*