title: [Determination of five components in compound hypotensive tablet by HPLC].
abstract: OBJECTIVE
  To establish a method for the determination of the five components (reserpine, chlordiazepoxide, hydrochlorothiazide, dihydralazine sulfate, triamterene) in compound hypotensive tablet.
  
  
  METHODS
  The chromatography was performed using a CN column with acetontrile-0.1 mol L(-1) sodium heptasulfonate solution (7:3) and (5:5) as the mobile phases. The detection wavelength was 267 nm for reserpine, chlordiazepoxide and hydrochlorothiazide, 310 nm for dihydralazine sulfate, 360 nm for triamterene.
  
  
  RESULTS
  The linear range of each component was tested, and the recovery and stability of each component was satisfactory, three lots of samples were determined using the method.
  
  
  CONCLUSIONS
  This is an accurate and credible quality control method for compound hypotensive tablet.
authors.affiliation: Beijing Institute for Drug Control, Beijing 100035, China. chebaoquan89@sina.com
authors.forename: Bao-quan
authors.initials: BQ
authors.lastname: Che
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000737:chemistry*; D002707:Chlordiazepoxide / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004078:Dihydralazine / Q000032:analysis*; D004338:Drug Combinations; D006852:Hydrochlorothiazide / Q000032:analysis*; D011786:Quality Control; D012110:Reserpine / Q000032:analysis*; D013607:Tablets; D014223:Triamterene / Q000032:analysis
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D013607:Tablets; D006852:Hydrochlorothiazide; D002707:Chlordiazepoxide; D012110:Reserpine; D004078:Dihydralazine; D014223:Triamterene