Prevention of intraventricular hemorrhage by indomethacin in male preterm infants.
Our multicenter Indomethacin Intraventricular Hemorrhage (IVH) Prevention Trial demonstrated a reduction of IVH in preterm infants. Analysis of our cohort by sex showed indomethacin halved the incidence of IVH, eliminated parenchymal hemorrhage, and was associated with higher verbal scores at 3 to 8 years in boys.
Ment
Laura R
LR
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA. Laura.ment@yale.edu
Vohr
Betty R
BR
Makuch
Robert W
RW
Westerveld
Michael
M
Katz
Karol H
KH
Schneider
Karen C
KC
Duncan
Charles C
CC
Ehrenkranz
Richard
R
Oh
William
W
Philip
Alistair G S
AG
Scott
David T
DT
Allan
Walter C
WC
D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007213:Indomethacin / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007807:Language Tests; D016015:Logistic Models; D008297:Male; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D012727:Sex Characteristics
D002317:Cardiovascular Agents; D007213:Indomethacin