Intravascular hemolysis in aortic stenosis.
A 67-year-old woman with rheumatic aortic stenosis for 20 years was admitted to our hospital. Although she had no overt symptoms, she had severe aortic valve stenosis with a transvalvular pressure gradient of more than 150 mmHg. She had also been suffering from anemia and mild chronic renal failure. A peripheral blood smear showed numerous fragmented erythrocytes. Hemoglobin was 8.4 g/dl, lactate dehydrogenase was 316 IU/l, haptoglobin was less than 7.3 mg/dl, and hemosiderinuria was evident. We diagnosed intravascular hemolysis related to aortic stenosis. After we performed an aortic valve replacement, fragmentation on the peripheral blood smear dramatically disappeared.
Tsuji
Akihiro
A
First Department of Internal Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu 514-8507.
Tanabe
Masaki
M
Onishi
Katsuya
K
Kitamura
Tetsuya
T
Okinaka
Tsutomu
T
Ito
Masaaki
M
Isaka
Naoki
N
Nakano
Takeshi
T
D000368:Aged; D000740:Anemia / Q000209:etiology; D001024:Aortic Valve Stenosis / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D004562:Electrocardiography; D004912:Erythrocytes / Q000378:metabolism / Q000473:pathology; D005260:Female; D006321:Heart / Q000503:physiopathology; D006350:Heart Valve Prosthesis; D006461:Hemolysis; D006801:Humans; D007564:Japan; D016896:Treatment Outcome