Synthetic approaches to the 2003 new drugs.
New drugs are introduced to the market every year and each individual drug represents a privileged structure for its biological target. In addition, these new chemical entities (NCEs) not only provide insights into molecular recognition, but also serve as drug-like leads for designing new future drugs. To these ends, this review covers the syntheses of 23 NCEs marketed in 2003.
Liu
Kevin K-C
KK
Pfizer Global Research and Development, Pfizer Inc, Groton, CT 06340, USA. kevin_k_liu@groton.pfizer.com
Li
Jin
J
Sakya
Subas
S
D015507:Drugs, Investigational / Q000138:chemical synthesis; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
D015507:Drugs, Investigational; D004364:Pharmaceutical Preparations