Does atopy protect against enteric infections?
Allergic sensitization to inhaled allergens and foods is common and is linked to the development of asthma, allergic rhinitis and eczema. In view of the morbidity associated with these diseases it is not clear why the genetic predisposition to atopy is so common. Children who are atopic are less likely to develop oral tolerance to ingested foods and as a result are more likely to have manifestations of food allergy including wheezing, skin rashes and gastrointestinal symptoms. Oral tolerance also develops to micro-organisms in the gastrointestinal tract. Children who are atopic may be protected against enteric infections in early childhood because they are less likely to be tolerant of these organisms. This may explain why individuals who are atopic are less likely to have evidence of previous infection with hepatitis A and other enteric organisms although they are just as likely to have been infected with respiratory pathogens.
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Department of Medicine, University of Auckland, Auckland, New Zealand.
D004198:Disease Susceptibility; D006506:Hepatitis A / Q000209:etiology*; D006801:Humans; D006920:Hygiene; D006969:Hypersensitivity, Immediate / Q000503:physiopathology*; D007239:Infections / Q000209:etiology*; D007410:Intestinal Diseases / Q000382:microbiology*; D008954:Models, Biological