[Study on association between aldosterone synthase gene polymorphism and the left ventricular structure and function of patients with dilated cardiomyopathy in China].
OBJECTIVE
To investigate the association between a -344 C/T polymorphism of aldosterone synthase gene (CYP11B2) and the left ventricular structure and function of patients with dilated cardiomyopathy (DCM) in China.


METHODS
Eighty-nine patients with DCM were genotyped by PCR-RFLP, and were divided into TT, TC, CC and TT+CC four groups by their genotypes, respectively. Left ventricular structure and function were assessed with echocardiography.


RESULTS
There was no significant difference between four groups in left ventricular diameters, mass and ejection fraction in patients with DCM.


CONCLUSIONS
The data were not in favor of a significant association between the aldosterone synthase gene CYP11B2 and the left ventricular structure and function in patients with DCM.
Rao
Li
L
Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhou
Bin
B
Wang
Bin
B
Wang
Yu-ping
YP
Li
Ying-bi
YB
Zhang
Lin
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002311:Cardiomyopathy, Dilated / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D013318:Stroke Volume; D016277:Ventricular Function, Left
D019405:Cytochrome P-450 CYP11B2