[Study on antiradiation effect of panaxatriol].
OBJECTIVE
To study antiradiation effect of panaxatriol (PT) and to provide an experiment basis for developing relative radiation-resistant skin care products.


METHODS
Mice were treated with PT or normal saline (the control group) before X-ray irradiation and were to observe the number of chromosme aberrations killed 3 hours after irradiation. The chromosome samples of bone marrow cells were prepared and chromatid mutation as well as aberrant cells.


RESULTS
PT can reduce the frequency of chromatid mutative induced by X-ray. Antiradiation effect was positively correlated with the dose of PT and the duration of drug, and negatively correlated with the dose of X-rays.


CONCLUSIONS
PT has significant antiradiation effect.
Li
Xiaokun
X
Jinan University, Guangzhou 510632.
Lin
Zhuofeng
Z
Huang
Yadong
Y
Deng
Qing
Q
Xu
Hua
H
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000528:radiation effects; D002875:Chromosomes / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D036145:Ginsenosides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D005894:Panax / Q000737:chemistry*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013997:Time Factors; D014315:Triterpenes / Q000494:pharmacology*; D014965:X-Rays
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D011837:Radiation-Protective Agents; D014315:Triterpenes; C004563:panaxatriol