title: Gene map of the extended human MHC.
abstract: The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.
authors.affiliation: Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: Roger
authors.initials: R
authors.lastname: Horton
authors.forename: Laurens
authors.initials: L
authors.lastname: Wilming
authors.forename: Vikki
authors.initials: V
authors.lastname: Rand
authors.forename: Ruth C
authors.initials: RC
authors.lastname: Lovering
authors.forename: Elspeth A
authors.initials: EA
authors.lastname: Bruford
authors.forename: Varsha K
authors.initials: VK
authors.lastname: Khodiyar
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Lush
authors.forename: Sue
authors.initials: S
authors.lastname: Povey
authors.forename: C Conover
authors.initials: CC
authors.lastname: Talbot
authors.forename: Mathew W
authors.initials: MW
authors.lastname: Wright
authors.forename: Hester M
authors.initials: HM
authors.lastname: Wain
authors.forename: John
authors.initials: J
authors.lastname: Trowsdale
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Stephan
authors.initials: S
authors.lastname: Beck
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D015894:Genome, Human; D006801:Humans; D007109:Immunity; D008285:Major Histocompatibility Complex; D005810:Multigene Family; D011110:Polymorphism, Genetic; D012343:RNA, Transfer / Q000235:genetics
chemical_list: D012343:RNA, Transfer