Cytotoxicity of three new triazolo-pyrimidine derivatives against the plant trypanosomatid: Phytomonas sp. isolated from Euphorbia characias.
There is no effective chemotherapy against diseases caused by Phytomonas sp., a plant trypanosomatid responsible for economic losses in major crops. We tested three triazolo-pyrimidine complexes [two with Pt(II), and another with Ru(III)] against promastigotes of Phytomonas sp. isolated from Euphorbia characias. The incorporation of radiolabelled precursors, ultrastructural alterations and changes in the pattern of metabolite excretion were examined. Different degrees of toxicity were found for each complex: the platinum compound showed an inhibition effect on nucleic acid synthesis, provoking alterations on the levels of mitochondria, nucleus and glycosomes. These results, together with others reported previously in our laboratory about the activity of pyrimidine derivatives, reflect the potential of these compounds as agents in the treatment of Phytomonas sp.
Magán
Rosa
R
Departamento de Parasitología, Instituto de Biotecnología, Universidad de Granada, Severo Ochoa s/n, E-18071 Granada, Spain.
Marín
Clotilde
C
Salas
Juan M
JM
Barrera-Pérez
Mario
M
Rosales
Maria J
MJ
Sánchez-Moreno
Manuel
M
D000818:Animals; D000981:Antiprotozoal Agents / Q000633:toxicity*; D028481:Euphorbia / Q000469:parasitology*; D011743:Pyrimidines / Q000633:toxicity*; D014230:Triazoles / Q000633:toxicity*; D014351:Trypanosomatina / Q000187:drug effects* / Q000302:isolation & purification / Q000648:ultrastructure
C419143:1,2,4-triazole(1,5a)pyrimidine; D000981:Antiprotozoal Agents; D011743:Pyrimidines; D014230:Triazoles