title: Frank Stinchfield Award. Titanium surface with biologic activity against infection.
abstract: Despite immense improvements, periprosthetic infection continues to compromise the result of otherwise successful joint arthroplasty. There are various limitations in the treatment of periprosthetic infection, the most important of which is the inability to deliver antibiotics to the local tissue without the need for intravenous administration. We have developed a novel route to covalently tether vancomycin to a metal (titanium) surface, which showed effective bactericidal activity because of a vancomycin coupling. The chemistry of tethering does not affect the biological activity of the biofactors that are attached to the metal surface. This technology holds great promise for the manufacturing of "smart" implants that can be self protective against periprosthetic infection, or can be used for the treatment of periprosthetic infections when they occur.
authors.affiliation: Department of Orthopaedic Surgery, WORK, Thomas Jefferson University, Philadelphia, PA 19107, USA. parvj@aol.com
authors.forename: Javad
authors.initials: J
authors.lastname: Parvizi
authors.forename: Eric
authors.initials: E
authors.lastname: Wickstrom
authors.forename: Allen R
authors.initials: AR
authors.lastname: Zeiger
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Adams
authors.forename: Irving M
authors.initials: IM
authors.lastname: Shapiro
authors.forename: James J
authors.initials: JJ
authors.lastname: Purtill
authors.forename: Peter F
authors.initials: PF
authors.lastname: Sharkey
authors.forename: William J
authors.initials: WJ
authors.lastname: Hozack
authors.forename: Richard H
authors.initials: RH
authors.lastname: Rothman
authors.forename: Noreen J
authors.initials: NJ
authors.lastname: Hickok
mesh_terms: D001363:Awards and Prizes; D018441:Biofilms; D020099:Coated Materials, Biocompatible; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D008422:Materials Testing / Q000379:methods*; D011336:Probability; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D012680:Sensitivity and Specificity; D013499:Surface Properties / Q000187:drug effects; D014025:Titanium; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D020099:Coated Materials, Biocompatible; D014640:Vancomycin; D014025:Titanium