title: Chemical aspects of amine oxidation by flavoprotein enzymes.
abstract: The mechanism of amine oxidation by flavoprotein enzymes is critically analysed through analysis of available experimental data. The review assesses available evidence for radical and polar mechanisms, drawing on data from model reactions, kinetic and spectroscopic approaches, structural and mutagenesis studies. The review focused on studies of mammalian monoamine oxidases and the bacterial enzymes trimethylamine dehydrogenase, monomeric sarcosine oxidase and dimethylglycine oxidase.
authors.affiliation: Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK. nss4@le.ac.uk
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Scrutton
mesh_terms: D000588:Amines / Q000378:metabolism*; D000818:Animals; D001419:Bacteria / Q000201:enzymology; D001665:Binding Sites; D005420:Flavoproteins / Q000378:metabolism*; D008322:Mammals; D008995:Monoamine Oxidase / Q000378:metabolism*; D010084:Oxidation-Reduction; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000737:chemistry / Q000378:metabolism*; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism; D050879:Sarcosine Oxidase
chemical_list: D000588:Amines; D005420:Flavoproteins; D008995:Monoamine Oxidase; D000587:Oxidoreductases Acting on CH-NH Group Donors; D010089:Oxidoreductases, N-Demethylating; D050879:Sarcosine Oxidase; C431689:dimethylglycine oxidase; C023186:trimethylamine dehydrogenase