Socks for the dilated heart. Does passive cardiomyoplasty have a role in long-term care for heart failure patients?
Dynamic cardiomyoplasty has been performed in over 1000 patients worldwide but due to limited success the procedure was never been adopted as an alternative approach for the surgical therapy of heart failure. However, observations in these patients showed that the nonstimulated or fibrotic transformed latissimus dorsi by itself led to an improvement of heart failure symptoms. These findings stimulated animal experiments with so-called passive cardiomyoplasty devices. In several animal models, the progression of heart failure could be stopped, and even reversed remodeling could be demonstrated. Several different devices have been developed and tested in animal models. The Acorn CorCap has already passed a successful clinical feasibility study. However, the final evaluation of two multicenter trials has to be awaited to assess the future role of this device in the treatment of heart failure.
Gummert
J F
JF
Klinik für Herzchirurgie, Herzzentrum Leipzig, Struempellstrasse 39, 04289 Leipzig, Germany. gumj@medizin.uni-leipzig.de
Rahmel
A
A
Bossert
T
T
Mohr
F W
FW
D000818:Animals; D018421:Cardiomyoplasty / Q000295:instrumentation* / Q000379:methods*; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D019317:Evidence-Based Medicine; D006333:Heart Failure / Q000150:complications / Q000601:surgery*; D006801:Humans; D019736:Prostheses and Implants; D011474:Prosthesis Design; D013526:Surgical Mesh; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000601:surgery*