title: Efficient synthesis of 4-aminoquinazoline and thieno[3,2-d]pyrimidin-4-ylamine derivatives by microwave irradiation.
abstract: [reaction: see text] A simple, efficient, and high-yielding synthesis of quinazolin-4-ylamine and thieno[3,2-d]pyrimidin-4-ylamine derivatives is reported under microwave irradiation conditions. Reaction conditions including temperature, solvent, and reaction time have been studied. An efficient parallel workup procedure was developed to generate a small library (23 compounds) in a short time period.
authors.affiliation: Albany Molecular Research, Inc., 21 Corporate Circle, Albany, New York 12212-5098, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Yoon
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.forename: Todd M
authors.initials: TM
authors.lastname: Stark
authors.forename: James C
authors.initials: JC
authors.lastname: Haber
authors.forename: Brian T
authors.initials: BT
authors.lastname: Gregg
authors.forename: Sara B
authors.initials: SB
authors.lastname: Stankovich