Fluorometabolite biosynthesis and the fluorinase from Streptomyces cattleya.
This review outlines the recent developments in uncovering the enzymes and intermediates involved in fluorometabolite biosyntheses in the bacterium Streptomyces cattleya. A particular emphasis is placed on the purification and characterisation of the fluorinase, the C-F bond forming enzyme which initiates the biosynthesis. Nature has hardly developed a biochemistry around fluorine, yet fluorinated organics are important commercial entities, therefore a biotransformation from inorganic to organic fluorine is novel and of contemporary interest.
Deng
Hai
H
School of Chemistry and Centre for Biomolecular Science, University of St Andrews, North Haugh, St Andrews KY16 9ST, UK.
O'Hagan
David
D
Schaffrath
Christoph
C
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000378:metabolism*; D005461:Fluorine; D006845:Hydrocarbons, Fluorinated / Q000378:metabolism*; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000378:metabolism*; D013302:Streptomyces / Q000201:enzymology* / Q000235:genetics*
D001426:Bacterial Proteins; D006845:Hydrocarbons, Fluorinated; D005461:Fluorine; D010088:Oxidoreductases; C495766:fluorinase