[Losartan versus enalapril in the reduction of left ventricular hypertrophy secondary to systemic arterial hypertension].
OBJECTIVE
To compare losartan and enalapril on reduction of left ventricular hypertrophy.


METHODS
Longitudinal, prospective, comparative, controlled study, of patients with moderate systemic arterial hypertension and echocardiographically proven left ventricular hypertrophy, randomized for treatment during six months with losartan 100 mg daily or enalapril 20 mg daily. The reduction of left ventricular mass index, was evaluated by echocardiogram basal and to six months.


METHODS
Student's t, Spearman and Pearson correlation coefficients.


RESULTS
85 patients finished the study (43 in the losartan group and 42 in the enalapril group). After six months of treatment, the blood pressure values and the left ventricular mass index decreased in losartan and enalapril (p = .0000001 y .00001 respectively), without significative difference in the intergrupal comparative. We found correlation between diastolic and media blood pressure reduction (but not for systolic) and the decrease in left ventricular mass index in both groups.


CONCLUSIONS
Both drugs were equally effective for control systemic arterial hypertension and produced a significant reduction of left ventricular hypertrophy, with modification of geometrical pattern to short time.
Uribe Flores
Jesús Daniel
JD
Hospital de Especialidades del Centro Médico Nacional "Adolfo Ruiz Cortines", Departamento de Medicina Interna del Hospital de Especialidades No. 14, IMSS. Veracruz, Ver. uribef_daniel@terra.com.mx
Hernández Jácome
Mercedes
M
Guevara Dondé
Jaime
J
Segura
Xóchitl
X
D000328:Adult; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D004656:Enalapril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy* / Q000209:etiology; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D019808:Losartan