title: Cyclic guanosine monophosphate role in human carcinoma pathogenesis.
abstract: In order to examine the cyclic nucleotides (cGMP) role in carcinoma growth and invasivity. We analyzed two cell lines, LSHT29 and 17GT, and tissues in patients with carcinoma and malignant tissues with (N+) and without (N-) lymph node metastases. Higher cGMP levels in pathological samples suggest a strong correlation between intracellular cGMP concentration and carcinoma progression.
authors.affiliation: Department of Applied Sciences of Oral and Dental Diseases, G. D'Annunzio University, Chieti, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Di Nicola
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Santoleri
authors.forename: Stefano
authors.initials: S
authors.lastname: Soscia
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Fioroni
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
authors.forename: Adriano
authors.initials: A
authors.lastname: Piattelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Spoto
mesh_terms: D002277:Carcinoma / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D006152:Cyclic GMP / Q000378:metabolism; D018450:Disease Progression; D005887:Gingival Neoplasms / Q000473:pathology*; D006157:Guanosine Monophosphate / Q000502:physiology*; D006801:Humans; D007202:Indicators and Reagents / Q000494:pharmacology; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000473:pathology; D011804:Quinolines / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D011804:Quinolines; D006157:Guanosine Monophosphate; C047117:bicinchoninic acid; D006152:Cyclic GMP