A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells.
Modified thymidine analogues have been highlighted as useful agents for the treatment of cancer and viral diseases due to their potent biological activities. In the present study, we synthesized a new thymidine analogue, 7-(3-bromo-phenoxy)-thymidine (4a), as a potential lead for anti-tumor agent. Compound 4a potently inhibits HeLa cell proliferation with an IC(50) of 15 microM.
Kim
Kyung Noo
KN
Chemical Genomics National Research Laboratory, Department of Bioscience and Biotechnology, Sejong University, Seoul 143-747, Korea.
Lee
Jiyong
J
Kim
Dong Hoon
DH
Yoo
Jong-Shin
JS
Kwon
Ho Jeong
HJ
D002455:Cell Division / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
C500015:7-(3-bromo-phenoxy)-thymidine; D013936:Thymidine