Characterization of cellulosic hot-melt extruded films containing lidocaine.
Hot-melt extrusion technology was used to produce thin films containing a model drug, lidocaine, and the cellulosic polymers hydroxypropyl cellulose (HPC) and hydroxypropyl methyl cellulose (HPMC). Two film formulations were extruded and compared, one containing only HPC and the other containing HPC:HPMC (80:20). Thermal analysis of the films using differential scanning calorimetry (DSC) suggested that the drug existed in the amorphous condition, which was confirmed by wide angle X-ray diffractometry. Sustained release of the drug was observed from both of the polymer matrices. Dissolution profiles suggested that HPMC retarded the drug release from HPC:HPMC (80:20) films. However, the mechanism of drug release from both of the films was predominantly diffusion of the drug through the polymer matrices. Incorporation of HPMC also increased both adhesive strength and work of adhesion as compared to the HPC-only films.
Repka
Michael A
MA
Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University 38677-1848, USA. marepka@olemiss.edu
Gutta
Kavitha
K
Prodduturi
Suneela
S
Munjal
Manish
M
Stodghill
Steven P
SP
D002482:Cellulose / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis*; D002626:Chemistry, Pharmaceutical; D007785:Lactose / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis*; D008012:Lidocaine / Q000032:analysis / Q000138:chemical synthesis*; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis*; D010078:Oxazines
D010078:Oxazines; D002482:Cellulose; D008747:Methylcellulose; D008012:Lidocaine; C071191:MK 458; C008079:hydroxypropylcellulose; D007785:Lactose