Total synthesis of (-)-disorazole C1.
The antimitotic natural product disorazole C1 was isolated in 1994 from the fermentation broth of the myxobacterium Sorangium cellulosum. We have developed a highly convergent and stereoselective total synthesis of this compound which establishes its relative and absolute configuration. Key features of our synthesis include a highly convergent strategy and selective functional group manipulations that minimize decomposition of the sensitive polyene macrodiolide.
Wipf
Peter
P
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA. pwipf@pitt.edu
Graham
Thomas H
TH
D018942:Macrolides; D009231:Myxococcales / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis*; D013237:Stereoisomerism
D018942:Macrolides; D010080:Oxazoles; C436383:disorazole C1