title: [Study on the compatibility of composite herbal medicines of the Zishen pill].
abstract: OBJECTIVE
  To study the compatibility of composite herbal medicines of the Zishen pill.
  
  
  METHODS
  50% ethanol extract test solution of the different combinations of composite herbal medicines of the Zishen pill were prepared. Pharmacologic experiments, such as anti-inflammatory, carbon particle clearance of RES were carried out with the solutions, and the corresponding pharmacological data were obtained. Variance analysis, canonical correlation and stepwise regression analysis were applied to interrelate the amount of each drug and the pharmacological data.
  
  
  RESULTS
  The results confirmed that Huangbo and Zhimu were the basis, while Rougui was the corrigent, which was conformed to the theory of TCM.
  
  
  CONCLUSIONS
  This study provides a significant try for studying the compatibility of composite herbal medicines.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Rong-hua
authors.initials: RH
authors.lastname: Dai
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Zhang
authors.forename: Kai-shun
authors.initials: KS
authors.lastname: Bi
mesh_terms: D031403:Anemarrhena / Q000737:chemistry; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002244:Carbon / Q000493:pharmacokinetics; D027424:Cinnamomum / Q000737:chemistry; D004338:Drug Combinations; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004423:Ear / Q000473:pathology; D004427:Ear Diseases / Q000473:pathology; D004487:Edema / Q000473:pathology; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D051379:Mice; D032102:Phellodendron / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D002244:Carbon