Assessment of the therapeutic and anticonvulsive efficacy of a drug combination consisting of trihexyphenidyle and HI-6 in soman-poisoned rats.
1. The influence of two anticholinergic drugs (atropine, trihexyphenidyle) on the effectiveness of antidotal treatment to eliminate soman-induced lethal effects and convulsions was studied in rats. 2. The oxime HI-6 when combined with centrally acting anticholinergic drug trihexyphenidyle seems to be more efficacious in the elimination of acute toxic effects of soman than its combination with atropine. 3. The findings support the hypothesis that the choice of the anticholinergic drug is important for the effectiveness of antidotal mixture in the case of antidotal treatment of soman-induced acute poisoning.
Kassa
Jirí
J
Purkyne Military Medical Academy in Hradec Králové, Czech Republic: Department of Toxicology. kassa@pmfhk.cz
Samnaliev
Ivan
I
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002619:Chemical Warfare Agents / Q000506:poisoning*; D002801:Cholinesterase Reactivators / Q000008:administration & dosage*; D003292:Convulsants / Q000506:poisoning*; D004359:Drug Therapy, Combination; D008297:Male; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D010091:Oximes; D011726:Pyridinium Compounds / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012999:Soman / Q000506:poisoning*; D014282:Trihexyphenidyl / Q000008:administration & dosage*
D000931:Antidotes; D002619:Chemical Warfare Agents; D002801:Cholinesterase Reactivators; D003292:Convulsants; D018727:Muscarinic Antagonists; D010091:Oximes; D011726:Pyridinium Compounds; D014282:Trihexyphenidyl; D012999:Soman; C022870:asoxime chloride