Similar dynamics of G-protein coupled receptors molecules in response to antagonist binding.
In this communication we would like to draw attention on surprisingly similar transition of G-protein coupled receptors (GPCR) molecules, observed in these kinetic studies made with different receptors and their antagonists.
Järv
Jaak
J
Institute of Organic and Bioorganic Chemistry, University of Tartu, 2 Jakobi Str, 51014 Tartu, Estonia. jaak.jarv@ut.ee
Oras
Aldo
A
D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics; D000818:Animals; D001921:Brain / Q000502:physiology*; D003838:Deoxyadenine Nucleotides / Q000493:pharmacokinetics; D018492:Dopamine Antagonists / Q000493:pharmacokinetics; D006801:Humans; D007700:Kinetics; D018727:Muscarinic Antagonists / Q000493:pharmacokinetics; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D058472:Receptors, Purinergic P2Y1; D013873:Thionucleotides / Q000493:pharmacokinetics
D000319:Adrenergic beta-Antagonists; D003838:Deoxyadenine Nucleotides; D018492:Dopamine Antagonists; D018727:Muscarinic Antagonists; C546382:P2RY1 protein, human; D011943:Receptors, Adrenergic, beta; D017448:Receptors, Dopamine D2; D043562:Receptors, G-Protein-Coupled; D011976:Receptors, Muscarinic; D018048:Receptors, Purinergic P2; D058472:Receptors, Purinergic P2Y1; D013873:Thionucleotides; C015109:2'-deoxyadenosine 5'-O-(1-thiotriphosphate)