title: A transcriptional profile of aging in the human kidney.
abstract: In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age.
authors.affiliation: Division of Nephrology, Stanford University Medical Center Stanford, California, USA.
authors.forename: Graham E J
authors.initials: GE
authors.lastname: Rodwell
authors.forename: Rebecca
authors.initials: R
authors.lastname: Sonu
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Zahn
authors.forename: James
authors.initials: J
authors.lastname: Lund
authors.forename: Julie
authors.initials: J
authors.lastname: Wilhelmy
authors.forename: Lingli
authors.initials: L
authors.lastname: Wang
authors.forename: Wenzhong
authors.initials: W
authors.lastname: Xiao
authors.forename: Michael
authors.initials: M
authors.lastname: Mindrinos
authors.forename: Emily
authors.initials: E
authors.lastname: Crane
authors.forename: Eran
authors.initials: E
authors.lastname: Segal
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Myers
authors.forename: James D
authors.initials: JD
authors.lastname: Brooks
authors.forename: Ronald W
authors.initials: RW
authors.lastname: Davis
authors.forename: John
authors.initials: J
authors.lastname: Higgins
authors.forename: Art B
authors.initials: AB
authors.lastname: Owen
authors.forename: Stuart K
authors.initials: SK
authors.lastname: Kim
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000818:Animals; D001706:Biopsy; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007107:Immune System / Q000473:pathology; D007249:Inflammation; D007668:Kidney / Q000378:metabolism* / Q000473:pathology*; D007672:Kidney Cortex / Q000473:pathology; D007678:Kidney Glomerulus / Q000378:metabolism; D007679:Kidney Medulla / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009132:Muscles / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000378:metabolism; D012044:Regression Analysis; D012737:Sex Factors; D013997:Time Factors; D014158:Transcription, Genetic
chemical_list: D012313:RNA