title: Immunoexpression of extracellular matrix proteins in human salivary gland development.
abstract: Immunoexpression of the extracellular matrix (ECM) proteins laminin, fibronectin, tenascin and types I, III and IV collagen was analyzed in the major and minor salivary glands of seven human fetuses at different gestational ages. The results showed the presence and localization of laminin, collagen IV and fibronectin around glandular structures at all stages of development. Tenascin was only detectable around excretory ducts. In the earliest stages of development, type I and type III collagen were presented as fine fibers delineating the glandular structures and delimiting the extension of the future lobule. As glandular development proceeded, the lobule was gradually filled with collagens and glandular tissue.
authors.affiliation: Department of Oral Pathology, São Leopoldo Mandic Dental Research Institute, Campinas, Brazil.
authors.forename: Cristiane
authors.initials: C
authors.lastname: Furuse
authors.forename: Patrícia Ramos
authors.initials: PR
authors.lastname: Cury
authors.forename: Ney Soares
authors.initials: NS
authors.lastname: de Araújo
authors.forename: Vera Cavalcanti
authors.initials: VC
authors.lastname: de Araújo
mesh_terms: D000906:Antibodies; D024042:Collagen Type I / Q000032:analysis; D024061:Collagen Type III / Q000032:analysis; D024141:Collagen Type IV / Q000032:analysis; D016326:Extracellular Matrix Proteins / Q000032:analysis*; D005333:Fetus; D005353:Fibronectins / Q000032:analysis; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis; D018987:Salivary Ducts / Q000196:embryology; D012469:Salivary Glands / Q000196:embryology*; D012470:Salivary Glands, Minor / Q000196:embryology; D019063:Tenascin / Q000032:analysis
chemical_list: D000906:Antibodies; D024042:Collagen Type I; D024061:Collagen Type III; D024141:Collagen Type IV; D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D007797:Laminin; D019063:Tenascin