Long-term evaluation of neuromyopathy in live donor FMF amyloidotic kidney transplant recipients.
BACKGROUND
Neuromyopathy was reported to be a problem among live donor familial Mediterranean fever (FMF) amyloid kidney transplant recipients. We aimed to address this issue on a long-term basis.


METHODS
14 FMF amyloid live donor kidney transplant recipients with a mean post-transplant follow-up period of 82.43 +/- 50.1 months in comparison to a control group of 19 non-amyloid renal transplant patients were subjected to thorough neurological examination, laboratory and electrophysiologic studies.


RESULTS
Both groups were comparable with regard to mean serum creatinine levels cyclosporine doses (p > 0.05), however trough cyclosporine levels were significantly lower in the amyloidotics than the controls (p = 0.04). Serum creatine phosphokinase was comparable in both groups (p = 0.59). The amyloid patients showed significantly increased polyphasic motor unit potentials and abnormal interference patterns in the biceps brachii muscle (p = 0.03) and the abductor polices brevis muscle (p = 0.05). Multivariate analysis showed a significant level for biceps myopathy in amyloidotics (p = 0.001). Both groups attained no difference with regard to median nerve conduction velocity.


CONCLUSIONS
Electrophysiologically evidenced neuromyopathy is more liable to occur in long-term live donor FMF amyloidotic kidney transplant recipients than in the other non-amyloidotic kidney transplant recipients even with no clinical manifestations or high creatine phosphokinase levels.
Sherif
Ali M
AM
Nephrology Unit, Mansoura Urology and Nephrology Center, Mansoura, Egypt. alimsherif@yahoo.com
Refaie
Ayman F
AF
Sheashaa
Hussein A
HA
El-Tantawy
Abd-Elhalim
AE
Sobh
Mohamed A
MA
D000328:Adult; D028226:Amyloidosis, Familial / Q000150:complications*; D003402:Creatine Kinase / Q000378:metabolism; D003430:Cross-Sectional Studies; D004576:Electromyography; D010505:Familial Mediterranean Fever / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008475:Median Nerve / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009468:Neuromuscular Diseases / Q000209:etiology* / Q000503:physiopathology; D011183:Postoperative Complications
D003402:Creatine Kinase