Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain.
Bipolar disorder is a chronic and severe mental disorder. Recently, new animal models have emerged to further investigate underlying mechanisms of bipolar disorder such as ouabain-induced hyperactivity in rats. In this study, we investigated the cerebrospinal fluid levels of S100B protein as a putative marker of astrocytic activity in bipolar mania induced by intracerebroventricular administration of ouabain in rats. Ouabain induced a two-fold increase in crossing responses in the open field test and increased 30% the cerebrospinal fluid concentration of S100B, as compared to vehicle group. Our findings reinforce the role of astroglial cells in the pathogenesis of bipolar disorder and S100B protein as a marker of bipolar mania.
Machado-Vieira
Rodrigo
R
Mood Disorders Program, HMIPV, Fundação Faculdade Federal de Ciências Medicas de Porto Alegre, RS, Brasil.
Schmidt
André P
AP
Avila
Thiago T
TT
Kapczinski
Flávio
F
Soares
Jair C
JC
Souza
Diogo O
DO
Portela
Luis Valmor C
LV
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid* / Q000209:etiology; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000633:toxicity*; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid*; D010042:Ouabain / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000134:cerebrospinal fluid*
D004791:Enzyme Inhibitors; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579158:S100b protein, rat; D010042:Ouabain