title: Dog star rising: the canine genetic system.
abstract: Purebred dogs are providing invaluable information about morphology, behaviour and complex diseases, both of themselves and humans, by supplying tractable populations in which to map genes that control those processes. The diversification of dog breeds has led to the development of breeds enriched for particular genetic disorders, the mapping and cloning of which have been facilitated by the availability of the canine genome map and sequence. These tools have aided our understanding of canine population genetics, linkage disequilibrium and haplotype sharing in the dog, and have informed ongoing efforts of the need to identify quantitative trait loci that are important in complex traits.
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, 50 South Drive, MSC8002, Building 50, Room 5222, Bethesda, Maryland 20892, USA.
authors.forename: Nathan B
authors.initials: NB
authors.lastname: Sutter
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Ostrander
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs / Q000235:genetics*; D005828:Genetics, Population; D016678:Genome; D015894:Genome, Human; D006801:Humans; D015810:Linkage Disequilibrium; D040641:Quantitative Trait Loci; D017422:Sequence Analysis, DNA