Construction of optically active CF3-containing quaternary carbon centers via stereospecific S(N)2' reaction.
[reaction: see text] Phosphates from 3-substituted 4,4,4-trifluorobut-2-en-1-ols were found to be effective for construction of CF3-containing quaternary carbon centers by way of Cu(I)-catalyzed Grignard reactions in the presence of catalytic amounts of CuCN and trimethylsilyl chloride (TMSCl) in an anti S(N)2' manner.
Kimura
Mitsuo
M
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.
Yamazaki
Takashi
T
Kitazume
Tomoya
T
Kubota
Toshio
T