title: Quinolone alkaloids with nitric oxide production inhibitory activity from Orixa japonica.
abstract: Four new quinolone alkaloids, orixalone A (1), B (2), C (3), and D (4), together with 12 known compounds were isolated from the stems of Orixa japonica. Orixalone A (1) inhibited nitric oxide production in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma and lipopolysaccharide.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
authors.forename: Masataka
authors.initials: M
authors.lastname: Itoigawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Furukawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirano
authors.forename: Tomiyasu
authors.initials: T
authors.lastname: Murata
authors.forename: Norio
authors.initials: N
authors.lastname: Kaneda
authors.forename: Youichi
authors.initials: Y
authors.lastname: Hisada
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Okuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D007371:Interferon-gamma / Q000494:pharmacology; D007564:Japan; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D010946:Plants, Medicinal / Q000737:chemistry*; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D008070:Lipopolysaccharides; D015363:Quinolones; C494925:orixalone A; D009569:Nitric Oxide; D007371:Interferon-gamma