[Relationship between gene transfer and cartilage tissue engineering].
Injury to the articular cartilage occurs under various pathological conditions such as trauma, inflammation and aging and is followed by osteoarthritic changes of the affected joints. Recently, some studies have revealed that enough chondrogenic proliferation was required using some factors such as TGF-beta and BMPs. We, also, have reported that synovial tissues include multipotent mesenchymal stem cells, which can differentiate into chondrocytes. These results suggest that not only are synovial cells a good therapeutic target of inflammatory joint diseases, but also can be utilized for tissue engineering of cartilage.
Seto
Hiroaki
H
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo.
Tanaka
Sakae
S
Seto
Hiroaki
H
Kurosawa
Hisashi
H
D000256:Adenoviridae; D000818:Animals; D052005:Bone Morphogenetic Protein Receptors, Type I; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D002358:Cartilage, Articular / Q000502:physiology*; D002454:Cell Differentiation / Q000235:genetics; D019902:Chondrocytes / Q000166:cytology*; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology; D039902:Multipotent Stem Cells; D010007:Osteochondritis / Q000628:therapy; D017346:Protein Serine-Threonine Kinases; D017978:Receptors, Growth Factor; D012038:Regeneration / Q000235:genetics*; D044968:Regenerative Medicine; D013583:Synovial Membrane / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods; D016212:Transforming Growth Factor beta / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D017978:Receptors, Growth Factor; D016212:Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D052005:Bone Morphogenetic Protein Receptors, Type I