[Risk factors for skin melanoma: genetic factors probably more important than exposure to sunlight].
Pigmented naevi (moles) are increasingly regarded as risk factors for the development of melanoma. The probability of melanoma developing from congenital naevi is proportional to the volume of the naevi. The risk of melanoma development from large naevi (diameter > 20 cm) is already present in the early years of childhood. The most important risk factor is the higher number of acquired naevi. This applies particularly to dysplastic (also called clinically atypical) naevi that not only represent the highest risk group but are also considered potential melanoma precursors. The development of acquired naevi (including dysplastic naevi) is dependant on the degree of skin pigmentation. The role of sunlight (ultraviolet radiation) in the development of melanoma is less significant than is generally assumed. The indirect effect of sunlight on melanoma development is to stimulate naevogenesis. One of the risk-modifying genes is the gene coding for melanocortin-1-receptor (MC1R). The presence of some gene variants has been found to lead to changes in melanin synthesis and is associated with a higher risk of melanoma. Recent research has shown that dysplastic naevi synthesise more phaeomelanin. There are also strong indications that dysplastic naevus cells suffer from chronic oxidative stress. This situation can lead to hypermutability and genetical instability.
Pavel
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Afd. Dermatologie, Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden. s.pavel@lumc.nl
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D006801:Humans; D008545:Melanoma / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D009426:Netherlands / Q000453:epidemiology; D009506:Nevus / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D009508:Nevus, Pigmented / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D013472:Sunlight / Q000009:adverse effects; D014466:Ultraviolet Rays / Q000009:adverse effects*
D044102:Receptor, Melanocortin, Type 1