Phosphoryl choline introduces dual activity in biomimetic ionomers.
Dual activity of phosphoryl choline (PC) functional poly(trimethylene carbonate) (PTMC) was found which induces the zwitterionic biomimetic PC group to form physical cross-links with ionomers in the bulk, and at the same time enrich at the surface of cast films. The formation of zwitterionic domains from a bifunctional PC-PTMC-PC (ionomer) provided firm films with a low elastic modulus in contrast to the tacky PTMC starting material (Mn approximately 3900 g/mol) with poor mechanical performance. In addition, the ionomer possessed improved hemocompatible properties that was explained by the enrichment of PC at the surface, suggesting a way to tailor the mechanical performance of biodegradable PTMC-based ionomers while providing its bioactivity. Tailored elasticity while maintaining hemocompatibility of a biodegradable ionomer should be of particular interest for a variety of in vivo applications.
Nederberg
Fredrik
F
Department of Materials Chemistry, Polymer Chemistry, Box 538, Uppsala University, S-751 21 Uppsala, Sweden.
Bowden
Tim
T
Nilsson
Bo
B
Hong
Jaan
J
Hilborn
Jöns
J
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis; D004146:Dioxanes / Q000138:chemical synthesis* / Q000737:chemistry; D004548:Elasticity; D007476:Ionophores / Q000138:chemical synthesis / Q000737:chemistry; D010766:Phosphorylation; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012212:Rheology
D001672:Biocompatible Materials; D004146:Dioxanes; D007476:Ionophores; D011108:Polymers; D010767:Phosphorylcholine; C059299:polytrimethylene carbonate