Stability of tin etiopurpurin.
Formulations of the tin etiopurpurin (SnET2) have been observed to undergo a spectral change on storage in dimethylformamide solution. This results in an alteration in the action spectrum, with enhanced photodynamic activity at lower wavelengths and decreased activity at 660 nm. On the basis of structural considerations, a reduced analog of SnET2 was prepared with an absorbance maximum at 640 nm. Formation of this product, termed SnET2H(2) relieves steric strain inherent in the parent molecule. Nuclear magnetic resonance, spectral and photodynamic data are consistent with the formation of SnET2H(2) during SnET2 storage. Slight modifications in the original synthesis are also reported, resulting in improved yields of intermediate products.
Poriel
Cyril
C
Department of Chemistry, Louisiana State University, Baton Rouge, LA, USA.
Kessel
David
D
Vicente
M Graça H
MG
D000818:Animals; D045744:Cell Line, Tumor; D004355:Drug Stability; D007939:Leukemia L1210 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008856:Microscopy, Fluorescence; D017319:Photosensitizing Agents / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013056:Spectrophotometry, Ultraviolet
D017319:Photosensitizing Agents; D011166:Porphyrins; C063166:tin etiopurpurin