Mapping non-class II H2-linked loci for type 1 diabetes in nonobese diabetic mice.
Major histocompatibility complex (MHC) plays a largely predominant role in the genetic predisposition to type 1 diabetes, in both humans and rodents. While class II loci have long been recognized as essential, they do not fully explain the MHC-linked genetic component of type 1 diabetes. In the present study, using new NOD congenic strains harboring defined chromosomal segments from C57BL/6 mice, we circumscribed three distinct loci influencing murine type 1 diabetes and tightly linked to but separated from the class II region. Our findings might guide the search for additional HLA-linked loci in human type 1 diabetes.
Deruytter
Nathalie
N
INSERM U580, Université Paris V-René Descartes, Paris, France.
Boulard
Olivier
O
Garchon
Henri-Jean
HJ
D000818:Animals; D002874:Chromosome Mapping; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology; D005819:Genetic Markers; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051379:Mice; D016688:Mice, Inbred NOD
D005819:Genetic Markers; D000949:Histocompatibility Antigens Class II