Unusual skin reactions after mosquito bites and Epstein-Barr virus reactivation in a patient with mantle cell lymphoma.
We detected Epstein-Barr virus (EBV) reactivation in a patient with mantle cell lymphoma (MCL). The patient, a 53-year-old Japanese man, had been referred to our hospital because of generalized lymphadenopathy, hepatosplenomegaly and lymphocytosis and gave a history of intense skin reactions to mosquito bites. The biopsied lymph node contained a monotonous proliferation of medium-sized lymphocytes with scant cytoplasm and slightly irregular nuclei that were CD5+, CD20+ and CD23-. Antibody titers of IgG against EBV viral capsid antigen and early antigen were increased, and EBV was detected in the lymphoma cells. This case may suggest a relationship between EBV and MCL.
Shigekiyo
Toshio
T
Department of Internal Medicine, Tokushima Prefectural Central Hospital, 1-10-3 Kuramoto-cho, Tokushima 770-0042.
Ohmori
Hiroko
H
Chohraku
Masahito
M
Ohtsuka
Shinsaku
S
Yamabe
Kazue
K
Takishita
Yoshihiro
Y
Takai
Shigeharu
S
Takahashi
Masanori
M
Wakatsuki
Shingo
S
D000818:Animals; D009033:Culicidae / Q000276:immunology; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007299:Insect Bites and Stings / Q000276:immunology; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000209:etiology; D008218:Lymphocytosis / Q000209:etiology; D020522:Lymphoma, Mantle-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology