Serotonin-1D hypothesis of obsessive-compulsive disorder: an update.
Support for the serotonin-1D (5-HT(1D)) hypothesis of obsessive-compulsive disorder (OCD) and related conditions comes from a variety of sources. Some pharmacologic challenges with the 5-HT(1D) agonist sumatriptan, and case reports in which prolonged administration of 5-HT(1D) agonists was associated with a therapeutic effect, suggest that 5-HT(1D) may play a role in obsessive-compulsive symptoms. Genetic studies have also found that polymorphism of the 5-HT(1D) gene may be preferentially transmitted to those patients with OCD. However, taking into account that OCD is a heterogeneous syndrome, the 5-HT(1D) hypothesis requires further investigation in order to disentangle the role of the 5-HT(1D) receptor in this common and often severe disorder.
Zohar
Joseph
J
Division of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Tel Aviv University, Israel. jzohar@post.tau.ac.il
Kennedy
James L
JL
Hollander
Eric
E
Koran
Lorrin M
LM
D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D044346:Receptor, Serotonin, 5-HT1D / Q000187:drug effects / Q000502:physiology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D018170:Sumatriptan / Q000494:pharmacology
D044346:Receptor, Serotonin, 5-HT1D; D017366:Serotonin Receptor Agonists; D018170:Sumatriptan