[Acute renal failure and 2,8-dihydroxyadeninuria].
We report the case of a 65 year old man, with a history of recurrent urolithiasis, who was referred for an acute renal failure. Investigations deny obstructive or glomerular involvement. 2,8-Dihydroxyadeninuria was diagnosed with the help of crystalluria. This rare metabolic disease is due to a deficiency of adenine phosphoribosyltransferase, a purine salvage enzyme. Allopurinol, a low purine diet and high fluid intake made possible the nearly entire regression of renal failure.
Hoffmann
M
M
Service de néphrologie et de dialyse, Centre hospitalier de Roubaix. maxime.hoffmann@free.fr
Talaszka
A
A
Bocquet
J P
JP
Le Monies de Sagazan
H
H
Daudon
M
M
D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D000225:Adenine / Q000031:analogs & derivatives* / Q000652:urine*; D000228:Adenine Phosphoribosyltransferase / Q000172:deficiency*; D000368:Aged; D006801:Humans; D008297:Male; D012008:Recurrence; D014545:Urinary Calculi / Q000209:etiology
C002993:2,8-dihydroxyadenine; D000228:Adenine Phosphoribosyltransferase; D000225:Adenine