Clinical implications of red blood cell and platelet storage lesions: an overview.
Both red blood cells and platelets undergo lesions upon storage which affect their function and possibly their clinical outcome. Some of these lesions are reversible, others not. Improved additive solutions and leukocyte depletion can delay the appearance of storage lesions. In addition, cellular apoptosis leads to numerous mitochondrial and surface changes during storage which have the potential to induce immune suppression by tuning down the innate immune system. This overview highlights some laboratory and clinical aspects of red cell and platelet storage lesions.
Solheim
B G
BG
Institute of Immunology, Rikshospitalet University Hospital, NO-0027 Oslo, Norway. bjarte.solheim@rikshospitalet.no
Flesland
O
O
Seghatchian
J
J
Brosstad
F
F
D017209:Apoptosis; D001771:Blood Banks / Q000592:standards*; D001792:Blood Platelets / Q000473:pathology / Q000502:physiology; D001793:Blood Preservation / Q000379:methods / Q000592:standards*; D004912:Erythrocytes / Q000473:pathology / Q000502:physiology; D006801:Humans