title: Frequency of haemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in Basra.
abstract: Basra, southern Iraq, was mapped for haemoglobinopathies and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Of 1064 couples aged 14-60 years recruited from the Public Health Laboratory, 49 had beta-thalassaemia trait, 69 had sickle-cell trait, 2 had haemoglobin D trait, 2 had haemoglobin C trait and 1 had high persistent fetal haemoglobin. Carriers of major beta-globin disorders comprised 11.48%. G6PD deficiency was detected in 133 individuals (12.5%). Only 10 couples (0.94%) were at risk of having children affected with either sickle-cell disease or beta-thalassaemia major. These defects constitute a real health problem and necessitate a management plan and public health education for early diagnosis and therapy.
authors.affiliation: Department of Paediatrics, College of Medicine, University of Basra, Basra, Iraq.
authors.forename: M K
authors.initials: MK
authors.lastname: Hassan
authors.forename: J Y
authors.initials: JY
authors.lastname: Taha
authors.forename: L M
authors.initials: LM
authors.lastname: Al-Naama
authors.forename: N M
authors.initials: NM
authors.lastname: Widad
authors.forename: S N
authors.initials: SN
authors.lastname: Jasim
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005319:Fetal Hemoglobin / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D006580:Genetic Carrier Screening; D005817:Genetic Counseling; D005820:Genetic Testing; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology* / Q000235:genetics* / Q000517:prevention & control; D006266:Health Education; D006445:Hemoglobin C Disease / Q000453:epidemiology / Q000235:genetics; D006453:Hemoglobinopathies / Q000453:epidemiology* / Q000235:genetics* / Q000517:prevention & control; D006455:Hemoglobins, Abnormal / Q000235:genetics; D006801:Humans; D007493:Iraq / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D020380:Needs Assessment; D011159:Population Surveillance; D015995:Prevalence; D012111:Residence Characteristics / Q000706:statistics & numerical data; D012307:Risk Factors; D012805:Sickle Cell Trait / Q000453:epidemiology / Q000235:genetics; D017086:beta-Thalassemia / Q000453:epidemiology
chemical_list: D006455:Hemoglobins, Abnormal; C032001:hemoglobin D; D005319:Fetal Hemoglobin