title: Impact of lung volume on MR signal intensity changes of the lung parenchyma.
abstract: OBJECTIVE
  To test the hypothesis that, in magnetic resonance (MR) imaging of healthy individuals, equal relative changes in lung volume cause equal relative changes in MR signal intensity of the lung parenchyma.
  
  
  METHODS
  In two experimental runs, 10 volunteers underwent spirometrically monitored MR imaging of the lungs, with MR images acquired at 10 incremental lung volumes ranging from total lung capacity to 10% above residual volume. Average signal intensity, signal variability, and signal intensity integrals were calculated for each volunteer and for each lung volume. The effect of lung volume on signal intensity was quantified using linear regression analysis complemented by the runs test. Slopes and intercepts of regression lines were compared with an analysis of covariance. Slopes of the lines of best fit for lung volumes and signal intensities from the two runs were compared to the slope of the line of identity. Comparisons between the two runs were visualized using Bland and Altman plots.
  
  
  RESULTS
  The slopes of the 10 individual regression lines yielded no significant differences (F = 1.703, P = 0.101; F = 1.321, P = 0.239). The common slopes were -0.556 +/- 0.027 (P = 0.0001) for the first and -0.597 +/- 0.0031 (P = 0.0001) for the second experimental run. Both slopes displayed no significant nonlinearity (P = 0.419 and P = 0.067). There was a strong association between changes in lung volumes (rs = 0.991, P = 0.0001) and changes in signal intensity (rs = 0.889, P = 0.0001) in the two experimental runs. Lines of best fit for lung volume and signal intensities were not significantly different from the slope of the line of identity (P = 0.321 and P = 0.212, respectively).
  
  
  CONCLUSIONS
  Equal changes in lung volume cause equal changes in MR signal intensity of the lung parenchyma. This linear and reproducible phenomenon could be helpful in comparing pulmonary MR signal intensity between individuals.
authors.affiliation: Department of Radiology, University of Vienna, Vienna, Austria. alexander.bankier@univie.ac.at
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Bankier
authors.forename: Carl R
authors.initials: CR
authors.lastname: O'Donnell
authors.forename: Vu M
authors.initials: VM
authors.lastname: Mai
authors.forename: Pippa
authors.initials: P
authors.lastname: Storey
authors.forename: Viviane
authors.initials: V
authors.lastname: De Maertelaer
authors.forename: Robert R
authors.initials: RR
authors.lastname: Edelman
authors.forename: Qun
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000328:Adult; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000033:anatomy & histology*; D008176:Lung Volume Measurements; D008279:Magnetic Resonance Imaging; D008297:Male; D013147:Spirometry; D014109:Total Lung Capacity; D014797:Vital Capacity