title: [A case of retroperitoneal neuroblastoma in an adult with extensive bone marrow metastasis].
abstract: We present a case of retroperitoneal neuroblastoma in a 27-year-old male with extensive bone marrow metastasis at the first presentation. After the simple excision of the tumor, adjuvant multi-drug chemotherapy, consisting of vincristine, actinomycin-D, ifosfamide, doxorubicin, carboplatin and etoposide, was carried out for 17 months, leading to complete remission. Ten months after completion of the chemotherapy, the tumor recurred with bone marrow metastasis. He further developed thoracic vertebral metastases resulting in paraplegia, and died of the disease 41 months after the presentation. The clinical course of this case, with its emphases especially on the effect of the chemotherapy, is described in this report. Since the clinical characteristics and treatment strategies for adult neuroblastoma have not yet been well established, they remain to be investigated in detail.
authors.affiliation: Dept of Orthopaedics, Aichi Cancer Center Hospital.
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamada
authors.forename: Hideshi
authors.initials: H
authors.lastname: Sugiura
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019046:Bone Marrow Neoplasms / Q000473:pathology / Q000556:secondary*; D016190:Carboplatin / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy / Q000556:secondary*; D010264:Paraplegia / Q000209:etiology; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D012888:Skull Neoplasms / Q000556:secondary; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D016190:Carboplatin; D007069:Ifosfamide