title: Impact of musculoskeletal disorders on quality of life: an inception cohort study.
abstract: OBJECTIVE
  To assess longitudinally the impact of new onset musculoskeletal (MSK) disorders on quality of life (QoL).
  
  
  METHODS
  An inception cohort of 1202 subjects in France aged 45-60 years was determined to be free of MSK problems at baseline. Over 28 months of follow up between 1996 and 1998, 310 were diagnosed with MSK disorders and matched for age and sex with 620 healthy controls. The impact of the MSK disorder onset on QoL was assessed by the change in SF-36 dimension scores over time, using a linear mixed ANOVA model to compare the groups.
  
  
  RESULTS
  The incidence of MSK disorder was 13.6% per person-year in the spine, 4.2% per person-year in a joint, and 4.6% per person-year at an extra-articular site. The greatest change in QoL was a 10 point drop in the 100 point SF-36 bodily pain dimension scale in the MSK group. Compared with controls, subjects with an MSK disorder had significantly greater reductions in the following dimensions: bodily pain (a -7.4 point difference in change), vitality (-2.7), general health (-1.8), and physical functioning (-1.3). Within the MSK group, chronic disorders had a greater impact than acute ones on the physical functioning (-2.1), role emotional (-8.4), and social functioning (-5.9) dimensions.
  
  
  CONCLUSIONS
  New onset MSK disorders have a marked deleterious effect on QoL in the physical domain, with lesser effects on social and mental functioning. This evidence of an early significant impact on their QoL reinforces recent recommendations for early treatment and primary prevention.
authors.affiliation: EA 3444, Ecole de Santé Publique, Faculté de Médecine, 9 Avenue de la Forêt de Haye, F-54505 Vandoeuvre-les-Nancy, France.
authors.forename: C H
authors.initials: CH
authors.lastname: Roux
authors.forename: F
authors.initials: F
authors.lastname: Guillemin
authors.forename: S
authors.initials: S
authors.lastname: Boini
authors.forename: F
authors.initials: F
authors.lastname: Longuetaud
authors.forename: N
authors.initials: N
authors.lastname: Arnault
authors.forename: S
authors.initials: S
authors.lastname: Hercberg
authors.forename: S
authors.initials: S
authors.lastname: Briançon
mesh_terms: D001168:Arthritis / Q000453:epidemiology / Q000534:rehabilitation; D004812:Epidemiologic Methods; D005260:Female; D005602:France / Q000453:epidemiology; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D009140:Musculoskeletal Diseases / Q000453:epidemiology / Q000534:rehabilitation*; D011788:Quality of Life; D013122:Spinal Diseases / Q000453:epidemiology / Q000534:rehabilitation