[Gd-AAZTA]-: a new structural entry for an improved generation of MRI contrast agents.
An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex [Gd(AAZTA)]- shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents.
Aime
Silvio
S
Dipartimento di Chimica IFM, Università degli Studi di Torino, Via P. Giuria 7, I-10125 Torino, Italy. silvio.aime@unito.it
Calabi
Luisella
L
Cavallotti
Camilla
C
Gianolio
Eliana
E
Giovenzana
Giovanni B
GB
Losi
Pietro
P
Maiocchi
Alessandro
A
Palmisano
Giovanni
G
Sisti
Massimo
M
D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005682:Gadolinium / Q000737:chemistry*; D008024:Ligands; D008279:Magnetic Resonance Imaging; D008968:Molecular Conformation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013816:Thermodynamics
D003287:Contrast Media; D008024:Ligands; D009942:Organometallic Compounds; D005682:Gadolinium