[Study on chronic toxicity to rats of implantation of super-high molecular weight polylactate].
OBJECTIVE
To make sure whether super-high molecular weight polylactate is toxic to the body after it has been implanted into the body for a long period.


METHODS
We implanted super-high molecular weight polylactate into the rats and took the specimens of blood at 3, 6, 9, 12 months after the operation. The changes of proteins, electrolyte, enzyme and other indices were observed. At the same time, the tissue around the implants were taken out to carry out the histological observation.


RESULTS
At 3, 6, 9, 12 months after the operation, the levels of albumin, globulin, total bilirubin, direct bilirubin, triglyceride, glucose, K+, Na+, Cl-, Ca2+, alkaline phosphatase, glutamic-pyruvic transaminase in the blood plasma were all in the normal range; there were no significant differences between the experimental group and the control group. The level of lactate dehydrogenase increased slightly, but there was no statistically significant difference between the experimental group and the control group. There were no non-reversible immune rejection around the implants in the histological observation.


CONCLUSIONS
Super-high molecular weight polylactate is not toxic to the body after it has been implanted into the animals for a long period.
Liu
Lei
L
West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Li
Sheng-wei
SW
Tian
Wei-dong
WD
Zheng
Qian
Q
Wei
Shi-cheng
SC
Xiong
Cheng-dong
CD
Peng
Zhe
Z
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D001673:Biodegradation, Environmental; D018786:Bone Substitutes; D005260:Female; D020007:Implants, Experimental; D019344:Lactic Acid / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D008334:Mandible / Q000378:metabolism / Q000601:surgery*; D008970:Molecular Weight; D011091:Polyesters; D011108:Polymers / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001672:Biocompatible Materials; D018786:Bone Substitutes; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)