title: Ultrasound image-based computer model of a common carotid artery with a plaque.
abstract: Ultrasound scans were acquired from a common carotid artery in a patient with an early atherosclerotic plaque forming a mild asymmetrical stenosis. The 3D vascular geometry of the diseased arterial segment was reconstructed from a series of 2D cross-sectional images, and computational meshes for the flow and wall domains were developed. Numerical flow simulations incorporating coupled fluid-solid interaction were implemented using flow and pressure waveforms measured in vivo. The effects of wall distensibility were investigated by comparing the predictions obtained with different wall compliance, one with 'natural' compliance and another with a stiffer wall. Limited flow separation was predicted in the post-stenotic zone. The non-uniform thickness of the diseased wall restricted the wall motion locally and re-distributed the stress, giving raised concentrations at the plaque shoulders.
authors.affiliation: Department of Chemical Engineering and Chemical Technology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
authors.forename: K W
authors.initials: KW
authors.lastname: Lee
authors.forename: N B
authors.initials: NB
authors.lastname: Wood
authors.forename: X Y
authors.initials: XY
authors.lastname: Xu
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*; D003198:Computer Simulation; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008955:Models, Cardiovascular