title: Antibacterial activity of naphthoquinones and triterpenoids from Euclea natalensis root bark.
abstract: Phytochemical studies of an ethanolic extract of Euclea natalensis root bark afforded two new compounds, octahydroeuclein (1) and 20(29)-lupene-3 beta-isoferulate (2), in addition to three known compounds, shinanolone (3), lupeol, and betulin. The chemical structures of 1 and 2 were determined by spectroscopic means. Shinanolone (3) showed inhibitory activity against Gram-positive bacterial strains and a drug-sensitive strain of Mycobacterium tuberculosis at a concentration of 0.1 mg/mL.
authors.affiliation: Department of Botany, University of Pretoria, 0002 Pretoria, South Africa.
authors.forename: Oliver
authors.initials: O
authors.lastname: Weigenand
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Hussein
authors.forename: Namrita
authors.initials: N
authors.lastname: Lall
authors.forename: Jacobus J M
authors.initials: JJ
authors.lastname: Meyer
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D031262:Ebenaceae / Q000737:chemistry*; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D013019:South Africa; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000094042:Lupanes; D000094062:Betulinic Acid
chemical_list: D000995:Antitubercular Agents; D009285:Naphthoquinones; D014315:Triterpenes; C495017:20(29)-lupene-3 beta-isoferulate; D000094042:Lupanes; C495015:octahydroeuclein; C495016:shinanolone; C002503:betulin; D000094062:Betulinic Acid