The EGF-TM7 family of the rat.
EGF-TM7 receptors are adhesion class heptahelical molecules predominantly expressed by cells of the immune system. Based on an analysis of the recently unraveled genome, the EGF-TM7 family of the rat is described here. Like the mouse, the rat has three EGF-TM7 receptors--CD97, EMR1 and EMR4. The highest conservation between the orthologues lies within the membrane-spanning part and emphasizes the functional importance of this region.
Hamann
Jörg
J
Laboratory for Experimental Immunology, G1-106, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands. j.hamann@amc.uva.nl
D000595:Amino Acid Sequence; D000818:Animals; D002135:Calcium-Binding Proteins; D004815:Epidermal Growth Factor / Q000235:genetics; D066246:ErbB Receptors / Q000235:genetics*; D016678:Genome; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D009077:Mucins / Q000235:genetics; D005810:Multigene Family; D017434:Protein Structure, Tertiary; D051381:Rats; D011956:Receptors, Cell Surface / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled; D017386:Sequence Homology, Amino Acid
C094471:ADGRE1 protein, human; C496221:Adgre1 protein, rat; C496222:Adgre4 protein, rat; C490633:Adgre5 protein, mouse; C496220:Adgre5 protein, rat; D002135:Calcium-Binding Proteins; C464944:Emr4 protein, mouse; D008562:Membrane Glycoproteins; D009077:Mucins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D004815:Epidermal Growth Factor; D066246:ErbB Receptors