Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection.
There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had -336C were more susceptible to infection than were persons with -336T (odds ratio = 1.87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested.
Martin
Maureen P
MP
Basic Research Program, SAIC Frederick, National Cancer Institute, MD 21702, USA.
Lederman
Michael M
MM
Hutcheson
Holli B
HB
Goedert
James J
JJ
Nelson
George W
GW
van Kooyk
Yvette
Y
Detels
Roger
R
Buchbinder
Susan
S
Hoots
Keith
K
Vlahov
David
D
O'Brien
Stephen J
SJ
Carrington
Mary
M
D015815:Cell Adhesion Molecules / Q000235:genetics*; D015331:Cohort Studies; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D007263:Infusions, Parenteral; D037181:Lectins, C-Type / Q000235:genetics*; D009092:Mucous Membrane; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin