title: Effect of the interleukin-1 genotype on outcomes of regenerative periodontal therapy with bone replacement grafts.
abstract: BACKGROUND
  Previous studies have shown an association between a specific genotype for the inflammatory cytokine interleukin (IL)-1 and the severity of periodontal disease. The purpose of this study was to evaluate the effect of the IL-1 genotype on the outcomes of periodontal surgical regenerative treatment with bone replacement grafts.
  
  
  METHODS
  Forty-four patients with interproximal intrabony defects were treated with bone replacement grafts. Probing depths (PD) and clinical attachment levels (CAL) were measured before treatment and at least 9 months post-treatment. Whole-mouth plaque index (WMPI) and bleeding index (WMBI) were recorded as well. All patients were tested for the IL-1 genotype.
  
  
  RESULTS
  Thirteen (29.55%) of the patients were IL-1 genotype positive. There was no statistically significant difference between the genotype-positive and genotype-negative groups regarding age, smoking status, gender, WMPI, and WMBI. There was no significant difference in PD or CAL between the genotype-positive and genotype-negative groups at baseline. Genotype-positive patients had a smaller reduction in probing depth (1.86 mm versus 2.13 mm) and a greater gain of clinical attachment (1.20 mm versus 0.65 mm). These differences were not statistically significant (P = 0.70, P = 0.40). Multivariate regression analysis showed that presurgical PD significantly influenced post-surgical PD and CAL, and only WMPI significantly influenced CAL.
  
  
  CONCLUSIONS
  In this study, there was no evidence that the IL-1 genotype influences the clinical treatment outcomes of regenerative periodontal therapy with bone replacement grafts.
authors.affiliation: Division of Periodontics, Eastman Department of Dentistry, University of Rochester Eastman Dental Center, Rochester, NY 14620, USA. Oren_Weiss@urmc.rochester.edu
authors.forename: Oren I
authors.initials: OI
authors.lastname: Weiss
authors.forename: Jack
authors.initials: J
authors.lastname: Caton
authors.forename: Timothy
authors.initials: T
authors.lastname: Blieden
authors.forename: Susan G
authors.initials: SG
authors.lastname: Fisher
authors.forename: Sarah
authors.initials: S
authors.lastname: Trafton
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Hart
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000483:Alleles; D016301:Alveolar Bone Loss / Q000601:surgery*; D001861:Bone Regeneration / Q000235:genetics*; D016025:Bone Transplantation; D002874:Chromosome Mapping; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D012189:Retrospective Studies; D012737:Sex Factors; D012907:Smoking; D016896:Treatment Outcome
chemical_list: D007375:Interleukin-1