[The influence of substances revealing geroprotective of spontaneous carcinogenesis in mice].
The review presents the results of experimental studies conducted by the author. CBA, SHR, HER-2/neu and SAM mice revealed inhibition of age-related alterations in estrus function and spontaneous tumour development and showed life span extension under the influence of the pineal gland hormone Melatonin, synthetic peptide bioregulator Epitalon, delta-sleep-inducing peptide Deltaran, enterosorbent Aqualen and succinic acid containing preparation Neuronol (Noogam). The observed effect depended on the dose and conditions of administration, as well as genetic predisposition of the particular mice strains to tumour development.
Popovich
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D019588:Aging, Premature / Q000517:prevention & control*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002244:Carbon / Q000494:pharmacology / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D008550:Melatonin / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000517:prevention & control*; D009842:Oligopeptides / Q000494:pharmacology / Q000627:therapeutic use; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D013386:Succinates / Q000494:pharmacology / Q000627:therapeutic use
C110642:Akvalen; D015415:Biomarkers; C493850:Neuronol; D009842:Oligopeptides; D020011:Protective Agents; D013386:Succinates; D002244:Carbon; D008550:Melatonin; C421253:alanyl-glutamyl-aspartyl-glycine