title: High permissivity of human HepG2 hepatoma cells for influenza viruses.
abstract: Human HepG2 hepatoma cells are highly permissive for influenza virus type A and type B, even without the addition of trypsin, and they exhibit a marked cytopathic effect. This property greatly facilitates the primary isolation of influenza viruses. Virus replication was significantly reduced by the plasmin(ogen)-specific inhibitor tranexamic acid, and this suggests a potential role played by the plasminogen/tissue plasminogen activator complex at the surface of HepG2 cells. This might represent a new approach for study of the interrelations of this complex with influenza viruses.
authors.affiliation: INSERM U526-Laboratoire de Virologie, Faculté de Médecine, avenue de Valombrose, 06107 Nice cedex 2, France. lefebvre@unice.fr.
authors.forename: Laurence
authors.initials: L
authors.lastname: Ollier
authors.forename: Anne
authors.initials: A
authors.lastname: Caramella
authors.forename: Valérie
authors.initials: V
authors.lastname: Giordanengo
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Lefebvre
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D003588:Cytopathogenic Effect, Viral; D006801:Humans; D009980:Influenza A virus / Q000472:pathogenicity* / Q000502:physiology; D009981:Influenza B virus / Q000472:pathogenicity* / Q000502:physiology; D008113:Liver Neoplasms; D010959:Tissue Plasminogen Activator / Q000494:pharmacology; D014779:Virus Replication
chemical_list: D010959:Tissue Plasminogen Activator