title: Synthesis of coumarin derivatives with cytotoxic, antibacterial and antifungal activity.
abstract: The synthesis and selective biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and some of their derivatives were carried out. Compound 13 was found to be most potent cytotoxic agent with LD50 = 126.69 microg/ml. In antibacterial assay the compounds showed a broad spectrum of activities. Compound 11 exhibited a very high degree of plant growth inhibition at three levels of concentration. Compound 4 showed very promising antifungal activity against Candida albicans. Compounds 12 and 13 demonstrated excellent antioxidant activity.
authors.affiliation: HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Zafar S
authors.initials: ZS
authors.lastname: Saify
authors.forename: Muhammad Zarrar
authors.initials: MZ
authors.lastname: Khan
authors.lastname: Zia-Ullah
authors.forename: Iqbal M
authors.initials: IM
authors.lastname: Choudhary
authors.lastname: Atta-Ur-Rahman
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D029064:Araceae / Q000187:drug effects; D001156:Artemia / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D001681:Biological Assay / Q000379:methods; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D003374:Coumarins