title: The efficacy of a single daily dose of enoxaparin for deep vein thrombosis prophylaxis following total knee arthroplasty.
abstract: Deep vein thrombosis (DVT) is a major risk following total knee arthroplasty (TKA). This prospective outcomes study evaluates the efficacy of enoxaparin 40 mg once daily for 7 days after TKA, by documenting symptomatic and asymptomatic outcomes using bilateral lower extremity duplex ultrasound upon hospital discharge and on postoperative day 21 (+/-2). In 60 extremities, duplex ultrasound demonstrated a DVT prevalence of 16.7% (10) on the day of discharge and of 11.7% (7) on postoperative day 21. No new DVT or propagation of distal to proximal DVT were noted. For this small cohort, enoxaparin 40 mg daily demonstrates effective prophylaxis for DVT in TKA patients.
authors.affiliation: Scripps Center for Orthopaedic Research and Education, La Jolla, CA 92037, USA.
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Pulido
authors.forename: Steven N
authors.initials: SN
authors.lastname: Copp
authors.forename: Richard H
authors.initials: RH
authors.lastname: Walker
authors.forename: Lianette M
authors.initials: LM
authors.lastname: Reden
authors.forename: Mary E
authors.initials: ME
authors.lastname: Hardwick
authors.forename: Clifford W
authors.initials: CW
authors.lastname: Colwell
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D017984:Enoxaparin / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007279:Injections, Subcutaneous; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011300:Preoperative Care / Q000379:methods; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D016896:Treatment Outcome; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000517:prevention & control*
chemical_list: D017984:Enoxaparin