Molecular portraits of breast cancer: tumour subtypes as distinct disease entities.
This Review describes advances in the characterisation of breast tumour phenotypes using DNA microarrays and the identification of five subtypes of breast cancer with significant clinical implications.
Sørlie
Therese
T
Department of Genetics, Institute for Cancer research, The Norwegian Radium Hospital, Montebello, Oslo, Norway. rsorlie@labmed.uio.no
D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D019398:Genes, BRCA1; D016158:Genes, p53; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D010641:Phenotype; D016019:Survival Analysis