Acute tumour lysis syndrome after oral fludarabine in a patient with chronic lymphocytic leukaemia.
Acute tumour lysis syndrome (TLS) is a very rare complication of cytotoxic therapy in patients with chronic lymphocytic leukaemia (CLL). We report a patient with CLL who developed tumour lysis syndrome twice after oral fludarabine therapy. Both times TLS developed more than 2 weeks after the initiation of therapy. To our knowledge this is the first reported case of TLS in CLL precipitated by oral fludarabine.
Ramachandran
Akila
A
Doncaster Royal Infirmary, Doncaster, UK.
Majumdar
Gautam
G
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000628:therapy; D000284:Administration, Oral; D018450:Disease Progression; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015275:Tumor Lysis Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D014740:Vidarabine / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*
D014740:Vidarabine; C024352:fludarabine