title: Efficacy of glimepiride in type 2 diabetic patients treated with glibenclamide.
abstract: Multicentric study was conducted to evaluate the efficacy of glimepiride in the oral hypoglycemic agents therapy of type 2 diabetic patients treated with glibenclamide so far, and to claim an adequate use of this new generation sulfonylurea. In 66 diabetic outpatients, glibenclamide was switched to glimepiride. After 6 months' therapy, a significant reduction in fasting plasma IRI was observed in relatively hyperinsulinemic patients. In addition, weight reduction was achieved in patients with insulin resistance during this study. These findings suggest that glimepiride improves insulin resistance in hyperinsulinemic patients treated with glibenclamide. Also, glimepiride is favored especially for overweight, insulin-resistant patients inadequately controlled by glibenclamide.
authors.affiliation: HOSS Conference Group, Hyogo, Japan. tomhamag@hyo-med.ac.jp
authors.forename: Tomoya
authors.initials: T
authors.lastname: Hamaguchi
authors.forename: Takahisa
authors.initials: T
authors.lastname: Hirose
authors.forename: Hideki
authors.initials: H
authors.lastname: Asakawa
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Itoh
authors.forename: Keiji
authors.initials: K
authors.lastname: Kamado
authors.forename: Katsuto
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Koji
authors.initials: K
authors.lastname: Tomita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Masuda
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Watanabe
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Namba
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; C057619:glimepiride