title: Phosphatidylinositol increases HDL-C levels in humans.
abstract: Studies have shown that phosphatidylinositol (PI) can stimulate reverse cholesterol transport by enhancing the flux of cholesterol into HDL and by promoting the transport of high density lipoprotein-cholesterol (HDL-C) to the liver and bile. The goal of this study was to determine the safety and therapeutic value of PI after oral administration to normolipidemic human subjects. We performed a randomized 2 week study in 16 normolipidemic subjects. Subjects received either 2.8 or 5.6 g of PI, with or without food. PI was well tolerated by all subjects. PI significantly affected the levels of HDL-C and triglyceride in the plasma of subjects receiving PI with food. The lower dose showed a 13% increase in HDL-C, whereas the high dose showed an increase of 18% over the 2 week period. Both low- and high-dose groups showed significant increases in plasma apolipoprotein A-I. The high dose of PI also decreased plasma triglycerides by 36% in the fed subjects. These data suggest that after only 2 weeks, PI may have a comparable therapeutic value to niacin, with negligible side effects.
authors.affiliation: Liponex, Inc., Ottawa, Ontario, Canada, K2G 3R8.
authors.forename: Jim W
authors.initials: JW
authors.lastname: Burgess
authors.forename: Tracey A-M
authors.initials: TA
authors.lastname: Neville
authors.forename: Patricia
authors.initials: P
authors.lastname: Rouillard
authors.forename: Zdena
authors.initials: Z
authors.lastname: Harder
authors.forename: Donald S
authors.initials: DS
authors.lastname: Beanlands
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Sparks
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000378:metabolism; D001646:Bile / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood*; D015331:Cohort Studies; D005215:Fasting; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D009525:Niacin / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000494:pharmacology*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D010716:Phosphatidylinositols; D014280:Triglycerides; D009525:Niacin; D002784:Cholesterol