[Age-related peculiarities of effect of low dose ionizing radiation on blood antioxidant enzyme system status in Chernobyl's accident liquidation participant].
Age-dependency of activity of key blood antioxidant enzymes--superoxide dismutase (SOD), glutathione peroxidase and glutathione reductase has been estimated in 104 men and women aged 25-60 years participated in the liquidation of the Chernobyl's accident since 6 years after irradiation. Control group includes 35 age-matched men and women. The results of study on 18 children aged 7-15 years and 5 children aged 2-6 years born by irradiated parents are given as well. Nineteen children were in the control group. Low-dose irradiation was found modify the pattern of age-related dependency of all enzymes studied. Most susceptible chain was enzymes of glutathione cycle both in liquidators and children. Study of late effects has shown that young people (<30 years) as well as children are most susceptible to low-level irradiation whereas most resistant were middle-aged people. This observation should be taken into consideration at selection of high-risk groups in an industry linked with chronic low-dose irradiation.
Vartanian
L S
LS
Gurevich
S m
Sm
Kozachenko
A I
AI
Nagler
L G
LG
Burlakova
E B
EB
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D047852:Chernobyl Nuclear Accident; D002648:Child; D002675:Child, Preschool; D004798:Enzymes / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D011836:Radiation Tolerance / Q000502:physiology*; D011839:Radiation, Ionizing; D018788:Radioactive Hazard Release; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D004798:Enzymes; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase