title: The significance of salivary and serum interleukin 6 and basic fibroblast growth factor levels in patients with Sjögren's syndrome.
abstract: Role of various cytokines have been implicated in the development and perpetuation of Sjogren's syndrome (SS), but no specific cytokine could be determined as a major contributor to the SS. Salivary and serum interleukin 6 (IL-6) levels have been studied previously in patients with SS, but data upon salivary and serum basic fibroblast growth factor (bFGF) in SS are lacking. The aim of this study was to evaluate levels of salivary and serum IL-6 and bFGF in 18 patients with SS, age range 32-79, mean 54.05 years. Control group consisted of 23 healthy participants, mean age 25 years. Serum IL-6 and bFGF levels were not significantly different between patients with SS and healthy controls. Elevated levels of salivary IL-6 and bFGF in patients with SS when compared to the healthy controls were found (p<0.001). We might speculate that higher levels of salivary IL-6 and bFGF in patients with SS might originate from local production probably having source in the salivary glands.
authors.affiliation: Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia. vvboras@hotmail.com
authors.forename: Vanja Vucićević
authors.initials: VV
authors.lastname: Boras
authors.forename: Nada
authors.initials: N
authors.lastname: Cikes
authors.forename: Josip
authors.initials: J
authors.lastname: Lukac
authors.forename: Ana
authors.initials: A
authors.lastname: Cekić-Arambasin
authors.forename: Miso
authors.initials: M
authors.lastname: Virag
authors.forename: Andrija
authors.initials: A
authors.lastname: Bosnjak
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D017523:Croatia / Q000453:epidemiology; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry*; D012859:Sjogren's Syndrome / Q000453:epidemiology / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D015850:Interleukin-6; D016222:Fibroblast Growth Factor 2