title: Parallel supported synthesis of polyamine-imidazole conjugates.
abstract: [reaction: see text] A small collection of nine polyamine-imidazole conjugates, potentially acting as RNases A mimics, has been synthesized on SynPhase lanterns using amino alcohols and diamines as building blocks. Couplings were performed via S(N)2 alkylation of methanesulfonates with amines. The final introduction of N-4-nitrobenzyloxycarbonyldiamines allowed easy purification of the cleaved compounds.
authors.affiliation: Université Rennes 1, Institut de Chimie de Rennes, Synthèse et Extraction de Molécules à Visée Thérapeutique, Faculté des Sciences Biologiques et Médicales, 2 avenue du professeur Léon Bernard, 35043 Rennes, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Picard
authors.forename: Myriam
authors.initials: M
authors.lastname: Le Roch
authors.forename: Jacques
authors.initials: J
authors.lastname: Renault
authors.forename: Philippe
authors.initials: P
authors.lastname: Uriac