title: Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment.
abstract: Three HIV-infected patients with chronic hepatitis B (genotype A) were switched to adefovir therapy after unsuccessful lamivudine treatment. Surprisingly, adefovir therapy failed, although none of the virus isolates displayed mutations known to be associated with adefovir resistance (A181V, N236T). In two isolates we identified hepatitis B virus DNA polymerase mutation L217R, in one case we found multiple frameshifts in the same region. In all cases adefovir was replaced by tenofovir, resulting in a significant drop in the viral load.
authors.affiliation: Institut für Medizinische Mikrobiologie und Immunologie, Universität Bonn, 53105 Bonn, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Schildgen
authors.forename: Carl Knud
authors.initials: CK
authors.lastname: Schewe
authors.forename: Martin
authors.initials: M
authors.lastname: Vogel
authors.forename: Martin
authors.initials: M
authors.lastname: Däumer
authors.forename: Rolf
authors.initials: R
authors.lastname: Kaiser
authors.forename: Lutwin
authors.initials: L
authors.lastname: Weitner
authors.forename: Bertfried
authors.initials: B
authors.lastname: Matz
authors.forename: Jürgen Kurt
authors.initials: JK
authors.lastname: Rockstroh
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004259:DNA-Directed DNA Polymerase / Q000235:genetics; D015658:HIV Infections / Q000188:drug therapy*; D006509:Hepatitis B / Q000188:drug therapy*; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008297:Male; D009154:Mutation; D063065:Organophosphonates / Q000627:therapeutic use*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D000068698:Tenofovir; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine; C053001:adefovir; D000068698:Tenofovir; D004259:DNA-Directed DNA Polymerase; D000225:Adenine