The relationship between body mass index and a plasma lipid peroxidation biomarker in an older, healthy Asian community.
OBJECTIVE
To examine the association between body mass index (BMI) and the plasma level of a lipid peroxidation biomarker in a large sample of elderly healthy Asian population. This cross-sectional study included 1150 community-dwelling Japanese aged 70 years or older in 2002.


METHODS
We measured the lipid peroxidation biomarker 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) using the ELISA method. We also measured the weight and height and calculated the BMI as weight (kg)/height (m)2.


RESULTS
After adjustment for potential confounders, the mean +/- SE plasma 8-iso-PGF(2alpha) level was significantly higher in subjects with higher BMI: 21.1 +/- 0.8 pg/ml in those with BMI of 30.0 or more; 20.5 +/- 0.3 pg/ml in those with BMI between 25.0 and 29.9; 20.0 +/- 0.2 pg/ml in those with BMI between 18.5 and 24.9; and 19.0 +/- 0.7 pg/ml in those with BMI of less than 18.5 (p for trend = 0.011).


CONCLUSIONS
Our results demonstrated that in the healthy Asian population, there was a modest but significant relationship between BMI and the plasma lipid peroxidation level.
Ohmori
Kaori
K
Department of Public Health & Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. ohmori-k@umin.ac.jp
Ebihara
Satoru
S
Kuriyama
Shinichi
S
Ugajin
Takashi
T
Ogata
Mikiko
M
Hozawa
Atsushi
A
Matsui
Toshifumi
T
Tsubono
Yoshitaka
Y
Arai
Hiroyuki
H
Sasaki
Hidetada
H
Tsuji
Ichiro
I
D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015992:Body Mass Index; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood*; D006801:Humans; D007564:Japan; D015227:Lipid Peroxidation / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology*; D016036:Seroepidemiologic Studies
C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost