Diffusion imaging for evaluation of tumor therapies in preclinical animal models.
The increasing development of novel targeted therapies for treating solid tumors has necessitated the development of technology to determine their efficacy in preclinical animal models. One such technology that can non-invasively quantify early changes in tumor cellularity as a result of an efficacious therapy is diffusion MRI. In this overview we present some theories as to the origin of diffusion changes as a result of tumor therapy, a robust methodology for acquisition of apparent diffusion coefficient maps and some applications of determining therapeutic efficacy in a variety therapeutic regimens and animal models.
Moffat
B A
BA
Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, 1150 W. Medical Center Drive, MSRB III Rm 9303, Ann Arbor, MI, 48109-0503, USA. bmoffat@umich.edu
Hall
D E
DE
Stojanovska
J
J
McConville
P J
PJ
Moody
J B
JB
Chenevert
T L
TL
Rehemtulla
A
A
Ross
B D
BD
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009369:Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy*; D011379:Prognosis; D016896:Treatment Outcome
D000970:Antineoplastic Agents