title: Biologic data of Macaca mulatta, Macaca fascicularis, and Saimiri sciureus used for research at the Fiocruz primate center.
abstract: Physiological parameters of laboratory animals used for biomedical research is crucial for following several experimental procedures. With the intent to establish baseline biologic parameters for non-human primates held in closed colonies, hematological and morphometric data of captive monkeys were determined. Data of clinically healthy rhesus macaques (Macaca mulatta), cynomolgus monkeys (Macaca fascicularis), and squirrel monkeys (Saimiri sciureus) were collected over a period of five years. Animals were separated according to sex and divided into five age groups. Hematological data were compared with those in the literature by Student's t test. Discrepancies with significance levels of 0.1, 1 or 5% were found in the hematological studies. Growth curves showed that the sexual dimorphism of rhesus monkeys appeared at an age of four years. In earlier ages, the differences between sexes could not be distinguished (p < 0.05). Sexual dimorphism in both squirrel monkeys and cynomolgus monkeys occurred at an age of about 32 months. Data presented in this paper could be useful for comparative studies using primates under similar conditions.
authors.affiliation: Centro de Criação de Animais de Laboratório, Departamento de Primatologia-Fiocruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil. andrade@fiocruz.br
authors.forename: Márcia Cristina Ribeiro
authors.initials: MC
authors.lastname: Andrade
authors.forename: Carlos Torres
authors.initials: CT
authors.lastname: Ribeiro
authors.forename: Virgílio Ferreira da
authors.initials: VF
authors.lastname: Silva
authors.forename: Etelcia Moraes
authors.initials: EM
authors.lastname: Molinaro
authors.forename: Miguel Angelo Brück
authors.initials: MA
authors.lastname: Gonçalves
authors.forename: Marcos Antônio Pereira
authors.initials: MA
authors.lastname: Marques
authors.forename: Pedro Hernan
authors.initials: PH
authors.lastname: Cabello
authors.forename: José Paulo Gagliardi
authors.initials: JP
authors.lastname: Leite
mesh_terms: D000367:Age Factors; D000818:Animals; D001699:Biometry; D005260:Female; D008252:Macaca fascicularis / Q000033:anatomy & histology* / Q000097:blood / Q000254:growth & development; D008253:Macaca mulatta / Q000033:anatomy & histology* / Q000097:blood / Q000254:growth & development; D008297:Male; D012453:Saimiri / Q000033:anatomy & histology* / Q000097:blood / Q000254:growth & development; D012727:Sex Characteristics