title: [Effect of glutamine on the non-steroidal anti-inflammatory drug-induced bacterial translocation].
abstract: OBJECTIVE
  NSAIDs induce gut damage throughout the entire gastrointestinal tract and bacterial translocation. The aim of this study was to examine if administration of glutamine was able to prevent the NSAID-induced gut damages and bacterial translocation in the animal models.
  
  
  METHODS
  Rats were utilized into 5 groups; control group, diclofenac group, and diclofenac with glutamine 0.8, 1.6, and 3.2 g/kg/day group. The animals with glutamine were fed with L-glutamine for 4 days before diclofenac administration. Gut injury was induced by administration of a single dose of diclofenac (80 mg/kg orally). Intestinal permeability (24 hour urinary excretion of phenolsulfonphthalein), enteric aerobic bacterial counts, serum biochemical profiles and bacterial translocation to mesenteric lymph nodes, liver and spleen were measured.
  
  
  RESULTS
  Diclofenac caused the increase in intestinal permeability, enteric bacterial count, enteric protein and albumin loss and bacterial translocation. Administration of glutamine reduced the increase in intestinal permeability, protein losing enteropathy, enteric bacterial overgrowth and bacterial translocation induced by diclofenac.
  
  
  CONCLUSIONS
  Glutamine may have beneficial effects on NSAID-induced gut damage and bacterial translocation.
authors.affiliation: Department of Internal Medicine, Chungang University College of Medicine, Seoul, Korea.
authors.forename: Ji Yong
authors.initials: JY
authors.lastname: Ann
authors.forename: Sang Jung
authors.initials: SJ
authors.lastname: Kim
authors.forename: Sang Pyo
authors.initials: SP
authors.lastname: Han
authors.forename: Jeong Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jae Hyuk
authors.initials: JH
authors.lastname: Do
authors.forename: Jae Gyu
authors.initials: JG
authors.lastname: Kim
authors.forename: Sae Kyung
authors.initials: SK
authors.lastname: Chang
authors.forename: Woo Kyu
authors.initials: WK
authors.lastname: Jeon
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000633:toxicity; D018988:Bacterial Translocation / Q000187:drug effects*; D004008:Diclofenac / Q000494:pharmacology* / Q000633:toxicity; D005973:Glutamine / Q000494:pharmacology*; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*; D008297:Male; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005973:Glutamine; D004008:Diclofenac