Synthesis of coumarin derivatives with cytotoxic, antibacterial and antifungal activity.
The synthesis and selective biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and some of their derivatives were carried out. Compound 13 was found to be most potent cytotoxic agent with LD50 = 126.69 microg/ml. In antibacterial assay the compounds showed a broad spectrum of activities. Compound 11 exhibited a very high degree of plant growth inhibition at three levels of concentration. Compound 4 showed very promising antifungal activity against Candida albicans. Compounds 12 and 13 demonstrated excellent antioxidant activity.
Khan
Khalid Mohammed
KM
HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
Saify
Zafar S
ZS
Khan
Muhammad Zarrar
MZ
Zia-Ullah
Choudhary
Iqbal M
IM
Atta-Ur-Rahman
Perveen
Shahnaz
S
Chohan
Zahid H
ZH
Supuran
Claudiu T
CT
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D029064:Araceae / Q000187:drug effects; D001156:Artemia / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D001681:Biological Assay / Q000379:methods; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D000890:Anti-Infective Agents; D000975:Antioxidants; D003374:Coumarins