Soluble fibrin, C-reactive protein, fibrinogen, factor VII, antithrombin, proteins C and S, tissue factor, D-dimer, and prothrombin fragment 1 + 2 in men with acute myocardial infarction </=45 years of age.
To evaluate the contribution of hematologic factors and long-term inflammation to the development of myocardial infarction at a young age, we measured hematologic variables, including soluble fibrin and high-sensitivity C-reactive protein, in 90 patients who had myocardial infarction and 138 controls </=45 years of age. Plasma levels of soluble fibrin and C-reactive protein were significantly higher in patients than in controls. On multivariate regression analysis, soluble fibrin was the strongest predictor of myocardial infarction at a young age.
Saigo
Masahiko
M
Division of Cardiology, San Francisco General Hospital, and the University of California, San Francisco, San Francisco, California, USA. massi@m3.kufm.kagoshima-u.ac.jp
Waters
David D
DD
Abe
Satoshi
S
Biro
Sadatoshi
S
Minagoe
Shinichi
S
Maruyama
Ikuro
I
Tei
Chuwa
C
D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood*; D005337:Fibrin / Q000032:analysis*; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000473:pathology*; D011237:Predictive Value of Tests
D015415:Biomarkers; D005337:Fibrin