title: [A case of non-small cell lung carcinoma successfully treated with carboplatin and weekly paclitaxel under renal dysfunction].
abstract: A 73-year-old man was admitted to our hospital with productive cough and dyspnea. His chest X-ray and CT scan showed a mass lesion on the lower lung field, pleural effusion on the left side, metastatic lesion in the right lung, and multiple metastases in the liver. The diagnosis was non-small cell carcinoma of the lung. Unfortunately, he had suffered from chronic nephritis; his creatinine level was 2.1, and his creatinine clearance was 29 ml/min. He received 4 courses of combined chemotherapy of carboplatin (AUC 5, day 1) and weekly paclitaxel (60 mg/ m2, day 1, 8, 15) every 4 weeks. His subjective symptoms as side effects were mild except for accidental melena due to colon diverticulum. Almost all lesions identified at admission were regressed by the chemotherapy. Although renal dysfunction often prevents patients with lung cancer from receiving systemic chemotherapies, in this case the combined chemotherapy of carboplatin and weekly paclitaxel proved to be a relatively safe and effective therapy for those patients with renal dysfunction.
authors.affiliation: Dept of Internal Medicine, Osaka Chuo Hospital.
authors.forename: Masahide
authors.initials: M
authors.lastname: Mori
authors.forename: Etsuko
authors.initials: E
authors.lastname: Takeda
authors.forename: Kiyoaki
authors.initials: K
authors.lastname: Sakai
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Nishida
authors.forename: Kazuko
authors.initials: K
authors.lastname: Tamura
authors.forename: Ikuko
authors.initials: I
authors.lastname: Akedo
authors.forename: Koji
authors.initials: K
authors.lastname: Yanagi
authors.forename: Chisa
authors.initials: C
authors.lastname: Nakagawa
authors.forename: Mamiko
authors.initials: M
authors.lastname: Tsugawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Ono
authors.forename: Masaharu
authors.initials: M
authors.lastname: Kubo
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D002908:Chronic Disease; D004334:Drug Administration Schedule; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D009393:Nephritis / Q000150:complications; D017239:Paclitaxel / Q000008:administration & dosage; D016066:Pleural Effusion, Malignant / Q000209:etiology; D051437:Renal Insufficiency / Q000150:complications*
chemical_list: D016190:Carboplatin; D017239:Paclitaxel