Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum.
In the present study, we investigated the effect of fluoropyrimidines on the growth of Ureaplasma urealyticum. Addition of fluoropyrimidines strongly inhibited bacterial growth. Growth inhibition by these analogues could be reversed by addition of either thymidine or deoxyuridine, suggesting inhibition of thymidylate biosynthesis as the mechanism in operation.
Wehelie
Rahma
R
Department of Molecular Biosciences, Section of Veterinary Medical Biochemistry, The Swedish University of Agricultural Sciences, Uppsala, Sweden.
Eriksson
Staffan
S
Wang
Liya
L
D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D049109:Cell Proliferation; D004247:DNA / Q000737:chemistry / Q000187:drug effects; D003857:Deoxyuridine / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005467:Floxuridine / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry; D013936:Thymidine / Q000737:chemistry; D013997:Time Factors; D014509:Ureaplasma; D016990:Ureaplasma urealyticum / Q000187:drug effects*
D000964:Antimetabolites, Antineoplastic; D011743:Pyrimidines; D005467:Floxuridine; D004247:DNA; D013936:Thymidine; D003857:Deoxyuridine