The chromatographic data in QSAR assay of TIQs derivatives with beta2-adrenergic activity.
We performed QSAR analysis of beta2-adrenergic activity and chromatographic data of 4,6,8-trihydroxy-, 6,7-dihydroxy- and 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives. TLC plates (silica gel NP 60F(254) and silica gel RP2 60F(254) silanised precoated), impregnated with solutions of analogues of the selected amino acids were used as beta2-agonistic and antagonistic interaction models. QSAR analysis of the beta2-adrenergic activity and the chromatographic data of the solutes were made. A correlation between biological data and behaviour of the examined compounds in a chromatographic modifiable environment (S1-S3) was investigated by the linear regression analysis method.
Brzezińska
Elzbieta
E
Department of Analytical Chemistry, Medical University of Lódź, 1 Muszyńskiego Str., 90-151 Lódź, Poland.
Stolarska
Justyna
J
D000318:Adrenergic beta-Agonists / Q000737:chemistry*; D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D016014:Linear Models; D019999:Pharmaceutical Solutions / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D044005:Tetrahydroisoquinolines / Q000737:chemistry*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D019999:Pharmaceutical Solutions; D044005:Tetrahydroisoquinolines