title: [IL-8 and TNF-alpha in prostatic secretions as indications in evaluating chronic prostatitis].
abstract: OBJECTIVE
  To investigate the significance of the determination of IL-8 and TNF-alpha in prostatic secretions in the evaluation of chronic prostatitis.
  
  
  METHODS
  IL-8 and TNF-alpha levels in EPS were evaluated by ELISA in 90 men: controls (n = 12), CBP (n = 12), CPPS IIIA (n=38), CPPS IIIB (n=28). And the difference was analyzed between CBP or CPPS IIIA and CPPS IIIB or controls.
  
  
  RESULTS
  IL-8 and TNF-alpha levels in EPS were higher in men with CBP [(10967.5 +/- 3477.7) pg/ml, (84.1 +/- 54.7) pg/ml] or CPPS IIIA [(9268.4 +/- 2034.6) pg/ml and (32.6 +/- 18.6) pg/ml], but lower in men with CPPS IIIB [(2726.1 +/- 277.5) pg/ml, (12.6 +/- 7.1) pg/ml] or controls [(2800.0 +/- 320.2) pg/ml and (12.9 +/- 10.1) pg/ml] respectively. There was significant difference between CBP or CPPS IIIA and CPPS IIIB or controls (P < 0.01).
  
  
  CONCLUSIONS
  IL-8 and TNF-alpha are elevated in the EPS of the men with CBP and CPPS IIIA, and provide a novel means for the identification and characterization of chronic nonbacterial prostatitis/chronic pelvic pain syndrome. The cut-points for IL-8 and TNF-alpha to discriminate CBP or CPPS IIIA from CPPS IIIB or controls need further investigation.
authors.affiliation: Department of Urology, the First Hospital of Xi'an Jiaotong University, Institute of Urology, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. hedalin@yahoo.com.cn
authors.forename: Dalin
authors.initials: D
authors.lastname: He
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Hui
authors.initials: H
authors.lastname: He
authors.forename: Jie
authors.initials: J
authors.lastname: Shi
authors.forename: Xinyang
authors.initials: X
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Xunyi
authors.initials: X
authors.lastname: Nan
mesh_terms: D000328:Adult; D000368:Aged; D001826:Body Fluids / Q000737:chemistry; D016022:Case-Control Studies; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011472:Prostatitis / Q000175:diagnosis* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha