title: Phosphoryl choline introduces dual activity in biomimetic ionomers.
abstract: Dual activity of phosphoryl choline (PC) functional poly(trimethylene carbonate) (PTMC) was found which induces the zwitterionic biomimetic PC group to form physical cross-links with ionomers in the bulk, and at the same time enrich at the surface of cast films. The formation of zwitterionic domains from a bifunctional PC-PTMC-PC (ionomer) provided firm films with a low elastic modulus in contrast to the tacky PTMC starting material (Mn approximately 3900 g/mol) with poor mechanical performance. In addition, the ionomer possessed improved hemocompatible properties that was explained by the enrichment of PC at the surface, suggesting a way to tailor the mechanical performance of biodegradable PTMC-based ionomers while providing its bioactivity. Tailored elasticity while maintaining hemocompatibility of a biodegradable ionomer should be of particular interest for a variety of in vivo applications.
authors.affiliation: Department of Materials Chemistry, Polymer Chemistry, Box 538, Uppsala University, S-751 21 Uppsala, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Nederberg
authors.forename: Tim
authors.initials: T
authors.lastname: Bowden
authors.forename: Bo
authors.initials: B
authors.lastname: Nilsson
authors.forename: Jaan
authors.initials: J
authors.lastname: Hong
authors.forename: Jöns
authors.initials: J
authors.lastname: Hilborn
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis; D004146:Dioxanes / Q000138:chemical synthesis* / Q000737:chemistry; D004548:Elasticity; D007476:Ionophores / Q000138:chemical synthesis / Q000737:chemistry; D010766:Phosphorylation; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012212:Rheology
chemical_list: D001672:Biocompatible Materials; D004146:Dioxanes; D007476:Ionophores; D011108:Polymers; D010767:Phosphorylcholine; C059299:polytrimethylene carbonate