Unmasking hypotension by beta lactam during dextran sulfate low-density lipoprotein apheresis.
The authors report, for the first time, potentially fatal adverse effects of combined treatment using beta lactam and low-density lipoprotein (LDL) apheresis with dextran sulfate adsorption. A 62-year-old man was receiving LDL apheresis because of peripheral artery disease. Cefmetazole was administered to treat infection of a leg ulcer. Although antibiotics alone did not cause any allergic reactions, he manifested circulatory collapse during LDL apheresis. Possible mechanisms for shock were discussed.
Takenaka
Tsuneo
T
Shinjuku Suimei Clinic, Shinjuku, Tokyo, Japan.
Sakamoto
Masako
M
Suzuki
Hiromichi
H
D001781:Blood Component Removal / Q000009:adverse effects / Q000379:methods*; D016264:Dextran Sulfate / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007022:Hypotension / Q000209:etiology*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D047090:beta-Lactams / Q000009:adverse effects / Q000627:therapeutic use*
D008077:Lipoproteins, LDL; D047090:beta-Lactams; D016264:Dextran Sulfate