title: Transglottic acinic cell carcinoma. Case report and literature review.
abstract: Acinic cell carcinoma (ACC) is a rare tumor generally involving the parotid gland and infrequently the minor salivary glands with the potential for both local recurrence and metastatic spread when tracked for decades. The biological behavior of ACC cannot be predicted on the basis of histological features, and surgical stage is still the best predictor of clinical outcome. Only 5 cases of ACC of the larynx have been reported in the English literature. The authors present a case of a rare transglottic ACC in a 74-year-old woman. At admission, a submucosal mass involving the left arytenoid and adjacent aryepiglottic fold was noted. A CT scan of the head and neck region showed a mass of the left hemilarynx involving the paraglottic space and extending from the aryepiglottic fold to the sinus piriformis. Definitive histopathological examination showed an ACC with a large amount of clear cells. The patient was treated by radiotherapy alone (66 Gy in 7 weeks) with complete remission.
authors.affiliation: ENT Department, University of Padua, Treviso Regional Hospital, Treviso, Italy. pboscolorizzo@yahoo.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Boscolo-Rizzo
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: da Mosto
authors.forename: Carlo
authors.initials: C
authors.lastname: Marchiori
authors.forename: Paolo
authors.initials: P
authors.lastname: Boccato
mesh_terms: D000368:Aged; D018267:Carcinoma, Acinar Cell / Q000473:pathology* / Q000532:radiotherapy; D005260:Female; D005931:Glottis / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy