[Differences in cerebral glucose metabolism between frontotemporal lobar degeneration and Alzheimer's disease].
OBJECTIVE
To describe differences in cerebral glucose metabolism between frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD).


METHODS
14 patients with FTLD (7 f/7 m, mean age 60.1 years) and 14 patients with AD (7 f/7 m, mean age 59.5 years) were examined. [18F]FDG positron emission tomography (PET) scans were analysed with statistical nonparametric mapping (SnPM) and statistical parametric mapping (SPM99).


RESULTS
Significant decreases in glucose metabolism in FTLD compared to AD were detected in the left insula/left inferior frontal gyrus (Brodman area [BA]13, 45 and 47) and in the medial frontal gyrus bilaterally (BA10). A significant decrease in AD compared to FTLD was identified in the right middle temporal gyrus (BA39).


CONCLUSIONS
Cerebral PET could be a promising tool to discriminate FTLD from AD.
Poljansky
Stefan
S
Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg am Bezirksklinikum. stefan.poljansky@medbo.de
Ibach
Bernd
B
Vogel
Matthias
M
Männer
Peter
P
Marienhagen
Jörg
J
Hajak
Göran
G
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001786:Blood Glucose / Q000378:metabolism*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D003704:Dementia / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012016:Reference Values
D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18