title: Binding properties of the conjugates of oligo(2'-O-methylribonucleotides) with minor groove binders targeted to double stranded DNA.
abstract: Design, synthesis, physico-chemical and in vitro biological studies of new pyrimidine oligo(2'-O-methylribonucleotide) conjugates with oligocarboxamide minor groove binders (MGB) and benzoindoloquinoline intercalator (BIQ) are described. These conjugates formed stable triple helices with the target double-stranded DNA and inhibited its in vitro transcription upon binding.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia. danov@niboch.nsc.ru
authors.forename: D S
authors.initials: DS
authors.lastname: Novopashina
authors.forename: A N
authors.initials: AN
authors.lastname: Sinyakov
authors.forename: V A
authors.initials: VA
authors.lastname: Ryabinin
authors.forename: A G
authors.initials: AG
authors.lastname: Venyaminova
authors.forename: L
authors.initials: L
authors.lastname: Perrouault
authors.forename: E
authors.initials: E
authors.lastname: Brunet
authors.forename: C
authors.initials: C
authors.lastname: Giovannangeli
authors.forename: A S
authors.initials: AS
authors.lastname: Boutorine
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D012265:Ribonucleotides / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D012265:Ribonucleotides; D004247:DNA