[Vitamin K and bone quality].
Dietary vitamin K intakes becomes reduced with aging. Low vitamin K intakes are associated with an increased incidence of hip fractures and an increase of under carboxylated osteocalcin in elderly men and women. The increase of under carboxylated osteocalcin is a risk factor for fractures in osteoporosis. Vitamin K2 treatment is effective for the prevention of fractures, but not for the increase of bone mineral density in osteoporosis. Vitamin K2 administration could be a potential treatment to improve the bone quality.
Kishimoto
Hideaki
H
Department of Orthopedic Surgery, San-In Rosai Hospitals.
D000368:Aged; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology*; D005260:Female; D050723:Fractures, Bone / Q000517:prevention & control; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy; D014801:Vitamin A / Q000494:pharmacology* / Q000627:therapeutic use
D014801:Vitamin A