title: [Cartilage and mechanical stress from the point of the view of development, growth, pathology and therapeutic aspects].
abstract: Articular cartilage is always subjected to various types, magnitudes and cycles of mechanical stress. While it has been recognized that these stresses regulate the chondrocyte growth and differentiation, the mechanism is still unclear. Here, we summarize the effect of mechanical stress on cartilage metabolism from the point of view of development, growth, pathology and therapeutic aspect.
authors.affiliation: Okayama University Graduate School of Medicine and Dentistry, Department of Biochemistry and Molecular Dentistry.
authors.forename: Takuo
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Masaharu
authors.initials: M
authors.lastname: Takigawa
authors.forename: Takuo
authors.initials: T
authors.lastname: Kuboki
mesh_terms: D053674:Aggrecans; D000818:Animals; D002357:Cartilage Diseases; D064236:Cartilage Oligomeric Matrix Protein; D002358:Cartilage, Articular / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology*; D020219:Chondrogenesis / Q000235:genetics; D024043:Collagen Type II / Q000378:metabolism; D017364:Collagenases / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins / Q000378:metabolism; D006609:High Mobility Group Proteins / Q000502:physiology; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D037181:Lectins, C-Type; D064235:Matrilin Proteins; D053509:Matrix Metalloproteinase 13; D009569:Nitric Oxide / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism; D055758:SOX9 Transcription Factor; D013314:Stress, Mechanical; D014157:Transcription Factors / Q000502:physiology
chemical_list: D053674:Aggrecans; D064236:Cartilage Oligomeric Matrix Protein; D024043:Collagen Type II; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D006609:High Mobility Group Proteins; D007375:Interleukin-1; D037181:Lectins, C-Type; D064235:Matrilin Proteins; D011509:Proteoglycans; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; C577553:TSP5 protein, human; D014157:Transcription Factors; D009569:Nitric Oxide; D017364:Collagenases; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13; D015232:Dinoprostone