Synthesis and urease enzyme inhibitory effects of some dicoumarols.
Dicoumarols 1-10 with substituted phenyl residues at C-11 were synthesized and screened for their urease inhibition effects. All synthesized compounds showed varying degree of urease inhibitory activity ranging from IC50 = 74.30-91.35 microM.
Khan
Khalid M
KM
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan. hassaan2@super.net.pk
Iqbal
Sajid
S
Lodhi
Muhammad A
MA
Maharvi
Ghulam M
GM
Perveen
Shahnaz
S
Choudhary
M I
MI
Atta-Ur-Rahman
Chohan
Zahid H
ZH
Supuran
Claudiu T
CT
D001728:Dicumarol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007887:Fabaceae / Q000201:enzymology; D015394:Molecular Structure; D014510:Urease / Q000037:antagonists & inhibitors* / Q000737:chemistry
D004791:Enzyme Inhibitors; D001728:Dicumarol; D014510:Urease