Molluscicidal activity of synthetic lapachol amino and hydrogenated derivatives.
A series of new amino derivatives and a new partially hydrogenated derivative of the natural naphthoquinone lapachol were assayed for molluscicidal activity against Biomphalaria glabrata. These derivatives showed low to medium LC(50) values, and a 3.1 microg/mL value for the most potent derivative of the series. The toxicity is in agreement with the decrease of polar character of the tested compounds.
Silva
Tania M S
TM
Laboratório de Tecnologia Farmacêutica, LTF-UFPB, Campus I, Cidade Universitária, 58051-970 João Pessoa, PB, CP 5009, Brazil. sarmento@ltf.ufpb.br
Camara
Celso A
CA
Barbosa
Ticiano P
TP
Soares
André Z
AZ
da Cunha
Luciana C
LC
Pinto
Angelo C
AC
Vargas
Maria D
MD
D000588:Amines / Q000737:chemistry; D000818:Animals; D006859:Hydrogen / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008974:Mollusca / Q000187:drug effects*; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*
D000588:Amines; D009285:Naphthoquinones; D006859:Hydrogen; C008252:lapachol