CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults.
CCR2 is a minor coreceptor for human immune deficiency virus-1 (HIV-1) and its impact on HIV-1-related neuropsychological impairment (NPI) remains unknown. We studied the impact of CCR2-V64I polymorphisms on the development of NPI in 121 HIV-1 patients. The CCR2-64-I allele was associated with rate of progression to NPI when measured from the first study visit (Log Rank p=0.01) or from the estimated time of seroconversion (p=0.02). CCR2-V64I was not associated with plasma or CSF HIV-1 RNA load, suggesting that the impact of CCR2 on neuropathogenesis may involve alterations in inflammatory responses within the CNS rather than a direct impact on viral entry or replication.
Singh
Kumud K
KK
Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0672, USA. ksuingh@ucsd.edu
Ellis
Ronald J
RJ
Marquie-Beck
Jennifer
J
Letendre
Scott
S
Heaton
Robert K
RK
Grant
Igor
I
Spector
Stephen A
SA
D000328:Adult; D000704:Analysis of Variance; D018932:Chemokine CCL2 / Q000235:genetics; D003072:Cognition Disorders / Q000209:etiology* / Q000235:genetics*; D005260:Female; D006678:HIV / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000235:genetics; D019707:Receptors, Chemokine / Q000235:genetics*
C111835:CCL2 protein, human; C515334:CCR2 protein, human; D018932:Chemokine CCL2; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine