title: Koboquinone A and B, new metabolites of kobophenol a in rats.
abstract: Two new phase I metabolites of phytoestrogen kobophenol A (1), called koboquinone A (2) and B (3), have been isolated from the feces of rats orally administered 1. Their structures were determined by spectroscopic methods. 2 also showed activity of stimulating the proliferation of cultured osteoblasts.
authors.affiliation: The School of Pharmacy, Fudan University, Shanghai, China.
authors.forename: Gaolin
authors.initials: G
authors.lastname: Liang
authors.forename: Kejun
authors.initials: K
authors.lastname: Cheng
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
authors.forename: Changqi
authors.initials: C
authors.lastname: Hu
mesh_terms: D000818:Animals; D016227:Benzoquinones / Q000737:chemistry*; D001711:Biotransformation; D049109:Cell Proliferation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010006:Osteoblasts / Q000187:drug effects; D048789:Phytoestrogens / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D016227:Benzoquinones; D048789:Phytoestrogens; C499874:koboquinone A; C499873:koboquinone B