title: Quantitative trait loci (QTL) detection in multicross inbred designs: recovering QTL identical-by-descent status information from marker data.
abstract: Mapping quantitative trait loci in plants is usually conducted using a population derived from a cross between two inbred lines. The power of such QTL detection and the parameter estimates depend largely on the choice of the two parental lines. Thus, the QTL detected in such populations represent only a small part of the genetic architecture of the trait. In addition, the effects of only two alleles are characterized, which is of limited interest to the breeder, while common pedigree breeding material remains unexploited for QTL mapping. In this study, we extend QTL mapping methodology to a generalized framework, based on a two-step IBD variance component approach, applicable to any type of breeding population obtained from inbred parents. We then investigate with simulated data mimicking conventional breeding programs the influence of different estimates of the IBD values on the power of QTL detection. The proposed method would provide an alternative to the development of specifically designed recombinant populations, by utilizing the genetic variation actually managed by plant breeders. The use of these detected QTL in assisting breeding would thus be facilitated.
authors.affiliation: UMR 1095 INRA-UBP, 63039 Clermont-Ferrand Cedex 2, France. sebastien.crepieux@limagrain.com
authors.forename: Sébastien
authors.initials: S
authors.lastname: Crepieux
authors.forename: Claude
authors.initials: C
authors.lastname: Lebreton
authors.forename: Bertrand
authors.initials: B
authors.lastname: Servin
authors.forename: Gilles
authors.initials: G
authors.lastname: Charmet
mesh_terms: D003198:Computer Simulation; D003433:Crosses, Genetic; D003627:Data Interpretation, Statistical; D005819:Genetic Markers; D007178:Inbreeding; D040641:Quantitative Trait Loci
chemical_list: D005819:Genetic Markers