Inhibitory activity of cyanidin-3-rutinoside on alpha-glucosidase.
Cyanidin-3-rutinoside, a natural anthocyanin, inhibited alpha-glucosidase from baker's yeast in dose-responsive manner. The IC50 value was 19.7 microM +/- 0.24 microM, compared with the IC50 value of voglibose (IC50 = 23.4 +/- 0.30 microM). Cyanidin-3-rutinoside was found to be a non-competitive inhibitor for yeast alpha-glucosidase with a Ki value in the range of 1.31-1.56 x 10(-5)M. These results indicated that cyanidin-3-rutinoside could be classed as a new alpha-glucosidase inhibitor.
Adisakwattana
Sirichai
S
Department of Pharmacology, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
Ngamrojanavanich
Nattaya
N
Kalampakorn
Kanyarat
K
Tiravanit
Wilaiwon
W
Roengsumran
Sophon
S
Yibchok-Anun
Sirintorn
S
D000872:Anthocyanins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007294:Inositol / Q000031:analogs & derivatives* / Q000494:pharmacology; D007700:Kinetics; D015394:Molecular Structure; D015003:Yeasts / Q000201:enzymology; D000520:alpha-Glucosidases / Q000737:chemistry
D000872:Anthocyanins; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007294:Inositol; D000520:alpha-Glucosidases; C428983:cyanidin 3-rutinoside; C102817:voglibose