Phase locking in integrate-and-fire models with refractory periods and modulation.
It is known [8, 11, 16, 26] that phase locking can entrain frequency information when the leaky integrate-and-fire (IF) model of a neuron is forced by a periodic function. We show that this is still the case when the IF model is made more biologically realistic. We incorporate into our model spike dependent threshold modulation and refractory periods. Consecutive firing times from this model and their respective interspike intervals are related by an annulus map. We prove a general theorem concerning orientation reversing annulus twist homeomorphisms, which shows that our map admits a unique rotation number. This implies, in particular, that chaotic behaviour is not possible in our model and phase locking is predicted.
Gedeon
Tomás
T
Department of Mathematical Sciences, Montana State University, Bozeman, MT 59715, USA. gedeon@math.montana.edu
Holzer
Matt
M
D000200:Action Potentials / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*