title: Aspiration cytology of malignant fibrous histiocytoma after radiation therapy for carcinoma of the uterine cervix: a case report.
abstract: BACKGROUND
  Cytologic reports on malignant fibrous histiocytoma (MFH) following radiation therapy for carcinoma of the uterine cervix are very rare.
  
  
  METHODS
  A 59-year-old woman presented with slowly increasing pain in the left hip joint. Eight years earlier, she had received radiotherapy at a dosage of 5,000 cGy to the whole pelvis for carcinoma of the uterine cervix. An osteolytic lesion of the pelvic bone was revealed on computed tomography, and a hard tumor was palpable in the left pelvic cavity. Fine needle aspiration (FNA) of the tumor via the left vaginal wall obtained 0.5 mL of yellow fluid consisting of markedly anaplastic and pleomorphic giant cells. Frequent multinucleation and mitoses were observed, although no atypical spindle cells were observed. Immunocytochemistry disclosed vimentin reactivity. An open biopsy of the tumor revealed the histologic and immunohistochemical features of MFH arising in the pelvic cavity.
  
  
  CONCLUSIONS
  FNA of the pelvic lesion via the vaginal wall revealed an MFH in the radiation therapy field. This is one of the few reports dealing with FNA cytology of a postradiation sarcoma in the pelvic cavity.
authors.affiliation: Graduate School of Medical Sciences, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Arai
authors.forename: Toshiko
authors.initials: T
authors.lastname: Jobo
authors.forename: Miwa
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuramoto
mesh_terms: D044963:Biopsy, Fine-Needle; D002277:Carcinoma / Q000532:radiotherapy; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D010146:Pain / Q000209:etiology; D010384:Pelvic Bones / Q000000981:diagnostic imaging / Q000473:pathology; D010386:Pelvic Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects*; D012509:Sarcoma / Q000209:etiology / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy