[Effects of iodine-containing food on 99mTc and 131I uptake in patients with Graves' disease].
OBJECTIVE
To investigate the changes in 99mTc and 131I uptake in patients with Grave's disease after intake of iodine-containing food. METGIDSl The 3-hour and 24-hour radioactive iodine uptake (RAIU) and 99mTc uptake ratio (TI) were measured and the thyroid weight (TW) was estimated in 20 patients with Graves' disease both before and after restraint of iodine-containing diet.


RESULTS
Significant difference was found in RAIU and TI in patients after restraint of iodine-rich diet (Z=3.920, P=0.000 for 3-hour RAIU and Z=3.920, P=0.000 for 24-hour RAIU; Z=2.199, P=0.028 for TI and Z=3.920, P=0.000 for TW estimated from 99mTc images). The tendency in such changes was significantly different (Z=4.066, P=0.000 for RAIU and TI; Z=4.243, P=0.000 for RAIU and TW). After restraint of iodine-rich food, RAIU of 3-hour and 24-hour increased in all the patients, and TI decreased in 16, remained the same level in 2 and increased in 2 patients; TW decreased in 18 and increased in 2 patients.


CONCLUSIONS
Iodine-containing food has different effects on thyroid 131I and 99mTc uptakes, which decreases 131I uptake in all the patients and increases 99mTc in 90% of them.
He
Guo-rong
GR
Department of Nuclear Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 51028, China. heguorong@vip.sina.com
Ouyang
Wei
W
Liu
Jin-hua
JH
Liu
Wei-ying
WY
D000293:Adolescent; D000328:Adult; D005260:Female; D006111:Graves Disease / Q000378:metabolism*; D006801:Humans; D007455:Iodine / Q000008:administration & dosage*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000378:metabolism*
D007457:Iodine Radioisotopes; D007455:Iodine; D013670:Sodium Pertechnetate Tc 99m