[BMP and LMP-1 for intervertebral disc regeneration].
Some evidence indicates that intervertebral disc degeneration is associated with decreasing of matrix synthesis from disc cell. BMP-2 increased mRNA of aggrecan and Type II collagen. It also enhanced disc matrix (proteoglycan) production. Adenovirually mediated LMP-1 overexpression in intervertebral disc cells increased disc cell proteoglycan production through BMP-2 and BMP-7 mediated process.
Park
Jin Soo
JS
Department of Orthopaedic Surgery, Kurume University School of Medicine.
Nagata
Kensei
K
D048868:Adaptor Proteins, Signal Transducing; D053674:Aggrecans; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000502:physiology*; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D024043:Collagen Type II / Q000235:genetics / Q000378:metabolism; D003598:Cytoskeletal Proteins; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D018014:Gene Transfer Techniques; D006801:Humans; D007403:Intervertebral Disc / Q000166:cytology / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; D037181:Lectins, C-Type; D011509:Proteoglycans / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012038:Regeneration / Q000235:genetics*
D048868:Adaptor Proteins, Signal Transducing; D053674:Aggrecans; D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D024043:Collagen Type II; D003598:Cytoskeletal Proteins; D016326:Extracellular Matrix Proteins; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; D037181:Lectins, C-Type; C484380:PDLIM7 protein, human; D011509:Proteoglycans; D012333:RNA, Messenger