title: [Control of calcification by extracellular matrix].
abstract: Physiological calcification begins from crystallization of hydroxyapatite in extracellular matrix of both bones and teeth. Because calcification is exactly the extracellular event, organic components of extracellular matrix play important roles in control of calcification. The authors discuss the molecular regulation of calcification by organic components of extracellular matrix, focusing on the mineral/organic interaction.
authors.affiliation: Department of MENICON cartilage and Bone Regeneration, Graduate School of Medicine, The University of Tokyo.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Hoshi
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Ozawa
mesh_terms: D015055:1-Carboxyglutamic Acid / Q000502:physiology; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002113:Calcification, Physiologic / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D003460:Crystallization; D017886:Durapatite / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D015675:Osteocalcin / Q000502:physiology; D015676:Osteonectin / Q000502:physiology; D053495:Osteopontin; D010743:Phospholipids / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D011509:Proteoglycans / Q000502:physiology; D012795:Sialoglycoproteins / Q000502:physiology; D014070:Tooth / Q000378:metabolism
chemical_list: D015676:Osteonectin; D010743:Phospholipids; D011509:Proteoglycans; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D015675:Osteocalcin; D053495:Osteopontin; D010758:Phosphorus; D015055:1-Carboxyglutamic Acid; D003094:Collagen; D017886:Durapatite; D002118:Calcium