Radiation synthesis of interpolymer polyelectrolyte complex and its application as a carrier for colon-specific drug delivery system.
Novel pH-sensitive interpolymer polyelectrolyte complex was synthesized by gamma radiation-induced copolymerization of acrylic acid (AAc) and dimethyl aminoethyl methacrylate (DMAEMA). pH-dependent swelling showed different phase transitions depending on the copolymer composition and also showed the interpolymer polyelectrolyte complex formation at pH values ranged from pH 3 to pH 4. FT-IR and TGA was employed to study the complex formation. The influence of copolymer composition and pH value of the surrounding medium on the type of water diffusion in the glassy polymer was discussed. The ability of the prepared copolymer to be used as drug carrier for colon-specific drug delivery system was estimated using ketoprofen as a model drug.
El-Hag Ali Said
Amr
A
Polymer Chemistry Department, National Center for Radiation Research and Technology, 3 Ahmed El-Zomor St., El-Zohor Distr, P.O. Box 29, Nasr City, Cairo, Egypt. elhagali_a@hotmail.com
D000179:Acrylates / Q000737:chemistry* / Q000528:radiation effects; D000284:Administration, Oral; D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000528:radiation effects; D003106:Colon / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000528:radiation effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry* / Q000528:radiation effects; D004058:Diffusion; D004337:Drug Carriers / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry* / Q000528:radiation effects; D004573:Electrolytes / Q000737:chemistry; D005720:Gamma Rays; D005766:Gastrointestinal Contents / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry / Q000528:radiation effects; D006863:Hydrogen-Ion Concentration; D007660:Ketoprofen / Q000008:administration & dosage* / Q000737:chemistry; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry* / Q000528:radiation effects; D010316:Particle Size
D000179:Acrylates; D020099:Coated Materials, Biocompatible; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004573:Electrolytes; D020100:Hydrogels; D008689:Methacrylates; D007660:Ketoprofen; C036658:acrylic acid; C049840:2-(dimethylamino)ethyl methacrylate