Ruthenium- and gold-catalysed sequential reactions: a straightforward synthesis of substituted oxazoles from propargylic alcohols and amides.
A convenient and straightforward one-pot reaction of propargylic alcohols bearing a terminal alkyne moiety with amides by the sequential action of ruthenium and gold catalysts gives the corresponding substituted oxazoles in good yields with a complete regioselectivity.
Milton
Marilyn Daisy
MD
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
Inada
Youichi
Y
Nishibayashi
Yoshiaki
Y
Uemura
Sakae
S