title: Genetic control of retrovirus susceptibility in mammalian cells.
abstract: Host cellular genes can have profound effects on retrovirus replication. Many of these genes encode restriction factors that block virus infection; others encode positive factors that are exploited by the viruses. Recently, a number of such genes have been cloned and characterized, bringing into sharper focus the mechanisms and pathways exploited by these viruses. The major host factors involved in the early phase of the viral life cycle are discussed.
authors.affiliation: Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA. goff@cancercenter.columbia.edu
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Goff
mesh_terms: D000071480:APOBEC-3G Deaminase; D000818:Animals; D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins / Q000235:genetics; D002460:Cell Line; D021984:Cyclophilin A / Q000276:immunology; D003564:Cytidine Deaminase; D018076:DNA, Complementary / Q000235:genetics; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics; D005796:Genes; D015497:HIV-1 / Q000235:genetics / Q000276:immunology; D006801:Humans; D008253:Macaca mulatta / Q000235:genetics / Q000276:immunology; D051379:Mice; D009700:Nucleoside Deaminases; D011506:Proteins / Q000235:genetics / Q000276:immunology; D012097:Repressor Proteins; D012190:Retroviridae / Q000235:genetics* / Q000502:physiology; D012192:Retroviridae Infections / Q000235:genetics; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; D014779:Virus Replication
chemical_list: D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins; D018076:DNA, Complementary; C103189:Fv1 protein, mouse; D011506:Proteins; D012097:Repressor Proteins; D000070584:Tripartite Motif Proteins; C477346:TRIM5 protein, human; D044767:Ubiquitin-Protein Ligases; D009700:Nucleoside Deaminases; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase; D021984:Cyclophilin A