Molecular characterization of HIV type 1 isolates from untreated patients of Mumbai (Bombay), India, and detection of rare resistance mutations.
The molecular characterization of HIV-1 isolates in drug-naive cases in the early stages of HIV disease was studied in 128 cases from Mumbai (Bombay), India. Subtype C was largely predominant followed by A-C intersubtype recombinants, one subtype A and one CRF01 AE. Compared to subtype B, subtype C exhibited an important polymorphism; the percentages of substitutions could reach more than 90%. Two isolates showed M184V substitution the reverse transcriptase indicating resistance to 3TC.
Deshpande
Alaka
A
Grant Medical College and Sir JJ Hospital, Byculla, Mumbai, India.
Recordon-Pinson
Patricia
P
Deshmukh
Ranjana
R
Faure
Muriel
M
Jauvin
Valérie
V
Garrigue
Isabelle
I
Lafon
Marie-Edith
ME
Fleury
Hervé J
HJ
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000145:classification* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007194:India; D008969:Molecular Sequence Data; D009154:Mutation; D017422:Sequence Analysis, DNA
D019380:Anti-HIV Agents; D054303:HIV Reverse Transcriptase; D016333:HIV Protease