Synthesis of aryl sialosides using Mitsunobu conditions.
Mitsunobu conditions for the efficient synthesis of aryl alpha/beta-sialosides were developed. An oxidative work-up procedure was employed to avoid a cumbersome chromatographic separation from the 2,3-dehydro derivative of sialic acid, which is formed as a side-product.
Gao
Ganpan
G
Institute of Molecular Pharmacy, Pharmacenter of the University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
Schwardt
Oliver
O
Ernst
Beat
B
D006027:Glycosides / Q000138:chemical synthesis*; D008722:Methods; D019158:N-Acetylneuraminic Acid / Q000138:chemical synthesis*
D006027:Glycosides; D019158:N-Acetylneuraminic Acid