HIV viral shedding in semen: lack of correlation with systemic virus-specific CD8 responses.
Semen is a major transmission vector for HIV. Virus-specific CD8 T cells are critical in HIV control, but their relationship with semen viral load is unknown. We therefore examined the association between systemic HIV-specific IFN-gamma CD8 responses and viral load in the semen and blood of HIV-infected men. No correlation was observed between viral load in either semen or blood and systemic CD8 T-cell responses. Further studies of immune correlates of semen HIV shedding are needed.
Sheth
Prameet M
PM
Department of Medicine, University of Toronto, Toronto, Canada.
Shahabi
Kamnoosh
K
Rebbapragada
Anuradha
A
Kovacs
Colin
C
Dimayuga
Rowena
R
Chackalakkal
Sharon
S
MacDonald
Kelly
K
Mazzulli
Tony
T
Kaul
Rupert
R
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000635:transmission*; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D012313:RNA / Q000032:analysis / Q000097:blood; D012661:Semen / Q000821:virology*; D019562:Viral Load; D017201:Virus Shedding
D012313:RNA