title: New macrolides from the sponge Chondrosia corticata.
abstract: Three new oxazole-containing metabolites, neohalichondramide (5), (19Z)-halichondramide (6), and secohalichondramide (7), along with four previously reported compounds of the same structural class were isolated from the marine sponge Chondrosia corticata collected from Guam. The structures of novel compounds were determined on the basis of combined spectroscopic analyses. These compounds exhibited significant cytotoxicity and antifungal activity toward the human leukemia cell-line K562 and Candida albicans, respectively.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, #28, Yungun, Jongro, Seoul 110-460, Korea. shinj@snu.ac.kr
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Ji-Yun
authors.initials: JY
authors.lastname: Kim
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Shin
authors.forename: Jong-Woong
authors.initials: JW
authors.lastname: Ahn
authors.forename: Valerie J
authors.initials: VJ
authors.lastname: Paul
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020014:K562 Cells; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
chemical_list: C495172:(19Z)-halichondramide; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D018942:Macrolides; D010080:Oxazoles; C495170:neohalichondramide; C495173:secohalichondramide