Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis--case report and literature review.
The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal. The literature was reviewed and meningitis due to Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients was demonstrated. Meningococcal disease may be the first manifestation of complement deficiency; screening for complement function must be considered for those with invasive meningococcal disease, with posterior evaluation of the components of the terminal pathway of complement.
Rosa
Daniela Dornelles
DD
Internal Medicine Department, Nossa Senhora da Conceição Hospital, Porto Alegre, Rio Grande do Sul, Brazil. ddrosa@terra.com.br
Pasqualotto
Alessandro C
AC
de Quadros
Maurício
M
Prezzi
Sérgio Henrique
SH
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002443:Ceftriaxone / Q000627:therapeutic use; D003185:Complement C8 / Q000172:deficiency*; D006801:Humans; D008297:Male; D008585:Meningitis, Meningococcal / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D012008:Recurrence
D000900:Anti-Bacterial Agents; D003185:Complement C8; D002443:Ceftriaxone