title: The influence of asymptomatic significant carotid disease on mortality and morbidity in patients undergoing coronary artery bypass surgery.
abstract: OBJECTIVE
  Controversy exists regarding the optimal management of patients with coexisting coronary and extracranial carotid artery disease. This study investigates the incidence of death, cerebrovascular events and myocardial infarction (MI) in patients with asymptomatic significant carotid artery disease undergoing coronary artery bypass graft (CABG) surgery.
  
  
  METHODS
  Prospective cohort.
  
  
  METHODS
  Fifty patients with asymptomatic carotid stenoses > or =70% associated with cervical bruits undergoing CABG without prophylactic carotid endarterectomy (CEA) were followed up over a median period of 68 months following surgery cerebrovascular events, MI and mortality were recorded. All patients received optimal secondary prevention for cardiovascular disease unless contraindicated.
  
  
  RESULTS
  No cerebrovascular events occurred within 30 days of surgery. One patient suffered an ipsilateral transient ischaemic attack (TIA) 14 months after CABG. Two patients died within 30 days; one from an MI, the other from pancreatitis. Three deaths occurred after 30 days; one from MI, one from primary lung cancer and one following rupture of an abdominal aortic aneurysm. No non-fatal MIs occurred.
  
  
  CONCLUSIONS
  In this patient group the overall risk of death, cerebrovascular events and MI was 4% during the first 30 days postoperatively and 8% thereafter. This compares favourably with published series for staged or combined CEA-CABG procedures. For asymptomatic significant carotid disease, prophylactic CEA prior to CABG does not appear to confer any advantage over CABG alone.
authors.affiliation: Department of Vascular Surgery, Manchester Royal Infirmary, Manchester M13 9WL, UK.
authors.forename: J
authors.initials: J
authors.lastname: Ghosh
authors.forename: D
authors.initials: D
authors.lastname: Murray
authors.forename: N
authors.initials: N
authors.lastname: Khwaja
authors.forename: M O
authors.initials: MO
authors.lastname: Murphy
authors.forename: M G
authors.initials: MG
authors.lastname: Walker
mesh_terms: D000368:Aged; D016893:Carotid Stenosis / Q000150:complications / Q000453:epidemiology*; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000706:statistics & numerical data*; D003324:Coronary Artery Disease / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology; D011446:Prospective Studies; D020521:Stroke / Q000453:epidemiology / Q000209:etiology; D016896:Treatment Outcome