title: [The expression and interaction of cyclin D1 and p16 in fibroblasts of pathologic scars].
abstract: OBJECTIVE
  To investigate the expression of cyclin D1, p16, AR and ER in fibroblasts of scars for further understanding the interaction of these factors and the roles that they play in scar development.
  
  
  METHODS
  Thirty samples of mature scar, hypertrophic scar and keloid were detected with immunohistochemical method (SP technique) and compared with normal skin.
  
  
  RESULTS
  There were on positive results in normal skin and mature scars. The expression of cyclin D1, p16 and AR was higher in hypertrophic scars and keloids than in normal skin with significant difference (P < 0.05). The expression of cyclin D1 in keloids was higher than in hypertrophic scars (P < 0.05). Though the expression of p16 was higher in keloids than in hypertrophic scars, the difference was not significant. There was significant correlation between the expression of cyclin D1 and AR in the pathologic scar.
  
  
  CONCLUSIONS
  The AR played an important role in scar formation and displayed its function through cyclin D1. The expression of p16 could suppress the excessive proliferation of cells to some extent. If the effect was not enough to resist the function of cyclin D1, long-term proliferation of cells would occur and lead to keloid formation. As the expression of cyclin D1 and p16 in hypertrophic scars was in a state of relative equilibrium, the cell proliferation showed a tendency of self-restriction.
authors.affiliation: Department of Plastic Surgery, Union Hospital of Tongji Medical College Huazhong Science and Technical University, Wuhan 430022, China.
authors.forename: Jia-Feng
authors.initials: JF
authors.lastname: Liu
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Zhang
authors.forename: Chuan-Xun
authors.initials: CX
authors.lastname: Yi
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Sun
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Li
mesh_terms: D002921:Cicatrix / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000032:analysis / Q000378:metabolism*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000032:analysis / Q000378:metabolism*; D005347:Fibroblasts / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D011944:Receptors, Androgen / Q000032:analysis / Q000378:metabolism; D011960:Receptors, Estrogen / Q000032:analysis / Q000378:metabolism; D012867:Skin / Q000737:chemistry / Q000378:metabolism / Q000473:pathology
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D019938:Cyclin D1