Lymphadenopathy after BCG vaccination in a child with chronic granulomatous disease.
We report a 15-month-old boy who developed an ulcer in the left axillary fold following bacillus Calmette-Guerin vaccination. Subsequent immunologic and genetic studies led to the diagnosis of chronic granulomatous disease. His mother had "lupus-like" lesions, described in some carriers of this disease, that were thus related to her son's diagnosis. Although in healthy subjects this vaccination is usually harmless, in instances of impaired immunity it may cause adverse reactions. When a vaccine-related complication occurs, an underlying immunodeficiency should be sought.
Vieira
Ana Paula
AP
Department of Dermatology, S. Marcos Hospital, Apartado 2242, 4701-965 Braga, Portugal. dermato@hsmbraga.min-saude.pt
Vasconcelos
Júlia
J
Fernandes
José Carlos
JC
Antunes
Henedina
H
Basto
A Sousa
AS
Macedo
Cristiana
C
Zaman
Afsana
A
Santos
Eugénia
E
Melo
J Castro
JC
Roos
Dirk
D
D001500:BCG Vaccine / Q000009:adverse effects / Q000276:immunology*; D006098:Granulocytes / Q000276:immunology / Q000378:metabolism; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D007223:Infant; D008206:Lymphatic Diseases / Q000209:etiology*; D008297:Male; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D011379:Prognosis; D012883:Skin Ulcer / Q000209:etiology
D001500:BCG Vaccine