An overview of the role of insulin in the treatment of hyperglycemia during acute myocardial ischemia.
Hyperglycemia on admission to the coronary care unit is associated with poor outcome. It has now been reasonably well established that intravenous insulin infusion during acute myocardial infarction has a protective role and reduces mortality. The present article reviews the current understanding of the cardioprotective effect of insulin and the recent advances in this area.
Imran
S Ali
SA
Department of Medicine, Division of Endocrinology, Dalhousie University, Halifax, Canada. ali.imran@cdha.nshealth.ca
Malmberg
K
K
Cox
Jafna L
JL
Ransom
Thomas Pp
TP
Ur
Ehud
E
D003325:Coronary Care Units; D003422:Critical Care / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D007262:Infusions, Intravenous; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D017202:Myocardial Ischemia / Q000503:physiopathology; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome
D007328:Insulin