Nutrient sensing and metabolic decisions.
Cells have several sensory systems that detect energy and metabolic status and adjust flux through metabolic pathways accordingly. Many of these sensors and signaling pathways are conserved from yeast to mammals. In this review, we bring together information about five different nutrient-sensing pathways (AMP kinase, mTOR, PAS kinase, hexosamine biosynthesis and Sir2), highlighting their similarities, differences and roles in disease.
Lindsley
Janet E
JE
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84132-3201, USA. janet@biochem.utah.edu
Rutter
Jared
J
D000263:Adenylate Kinase / Q000378:metabolism*; D000818:Animals; D006595:Hexosamines / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D037761:Sirtuins / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases
D006595:Hexosamines; D011494:Protein Kinases; C546842:MTOR protein, human; C116037:PAS domain kinases; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases; D000263:Adenylate Kinase; D037761:Sirtuins