[Effects of anticoagulation therapy with low molecular weight heparin in acute pancreatitis].
OBJECTIVE
To evaluate the effects of anticoagulation therapy with low molecular weight heparin in acute pancreatitis.


METHODS
Low molecular weight heparin, in a dose of 40 mg or 0.01 ml/kg, by subcutaneous injection, every 12 hours, was administered to 17 acute pancreatitis patients combined with conventional therapy. The changes of serum enzymology and prognosis in patients treated with low molecular weight heparin or conventional therapy were observed.


RESULTS
Anticoagulation by low molecular weight heparin could significantly decrease the blood white cell count of patients with acute pancreatitis and increase their arterial blood oxygen partial pressure. It could cut down the duration of hospitalization and reduce the aggravation rate, secondary operation rate, and mortality of these patients without increasing hemorrhagic tendency or its related complications.


CONCLUSIONS
Anticoagulation therapy with low molecular weight heparin is safe and effective in the treatment of acute pancreatitis, and it may improve its prognosis.
Jiao
Hua-bo
HB
304th Division, General Hospital of PLA, Beijing 100037, China.
Qiao
Zhi
Z
Tan
Xiang-long
XL
Du
Jun-dong
JD
Fei
Yang
Y
Wang
Da-dong
DD
Li
Ji-ye
JY
Yao
Yong-ming
YM
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000188:drug therapy*; D011379:Prognosis
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight