Antinociceptive effect of Melastoma malabathricum ethanolic extract in mice.
The antinociceptive effect of the ethanolic extract of Melastoma malabathricum (MME) was investigated using acetic acid-induced abdominal writhing test and hot-plate test in mice. It was demonstrated that the extract (30-300 mg/kg, i.p.) strongly and dose-dependently inhibited the acetic acid-induced writhing with an ED(50) of 100 (78-160) mg/kg i.p. It also significantly increased the response latency period to thermal stimuli. Furthermore, the nonselective opioid receptor antagonist, naloxone blocked the antinociceptive effect of the extract in both tests, suggesting that M. malabathricum may act both at peripheral and central levels.
Sulaiman
M R
MR
Department of Biomedical Sciences, Faculty of Medicine Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. mrs@medic.upm.edu.my
Somchit
M N
MN
Israf
D A
DA
Ahmad
Z
Z
Moin
S
S
D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D008297:Male; D035322:Melastomataceae; D051379:Mice; D008807:Mice, Inbred BALB C; D009270:Naloxone; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
D000700:Analgesics; D010936:Plant Extracts; D009270:Naloxone; D019342:Acetic Acid