Enhanced ultrafiltration using 7.5% icodextrin/1.36% glucose combination dialysate: a pilot study.
OBJECTIVE
A pilot study to compare the use of a combination dialysate (7.5% icodextrin/1.36% glucose) versus icodextrin 7.5% alone for the long dwell in patients on peritoneal dialysis (PD).


METHODS
A 4-week, prospective, randomized crossover study.


METHODS
A large regional renal unit providing treatment for a population of 1.7 million.


METHODS
Five patients on continuous ambulatory PD (CAPD) and 3 patients on automated PD.


METHODS
Long-dwell and 24-hour ultrafiltration volumes, body weight, 24-hour ambulatory blood pressure, and antihypertensive/diuretic tablet count.


RESULTS
The use of the combination dialysate resulted in an increase in the median (interquartile range) long-dwell ultrafiltration, from 750 (650-828) mL to 1000 (889-1100) mL (p < 0.001), and 24-hour ultrafiltration, from 739 (400-1623) mL to 956 (700-1750) mL (p < 0.001). Weight, blood pressure, and tablet count remained unchanged.


CONCLUSIONS
The use of the novel combination dialysate resulted in a 33% increase in long-dwell ultrafiltration and a 29% increase in 24-hour ultrafiltration.
Dallas
Fiona
F
Sheffield Kidney Institute, Sheffield, United Kingdom.
Jenkins
Sarah B
SB
Wilkie
Martin E
ME
D000328:Adult; D018592:Cross-Over Studies; D015314:Dialysis Solutions / Q000008:administration & dosage / Q000737:chemistry; D005260:Female; D005936:Glucans / Q000008:administration & dosage*; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D000077607:Icodextrin; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010865:Pilot Projects; D011446:Prospective Studies; D013997:Time Factors; D014462:Ultrafiltration
D015314:Dialysis Solutions; D005936:Glucans; D000077607:Icodextrin; D005947:Glucose