The promise of minocycline in neurology.
The capacity of minocycline to alleviate disease for several neurological disorders in animals is increasingly being recognised. Indeed, that one drug alone can attenuate the severity of disease in stroke, multiple sclerosis, spinal-cord injury, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis is astounding. In this review, we describe the evidence for the efficacy of minocycline in several animal models of neurological disease, discuss the mechanisms by which minocycline affects a range of neurological diseases with diverse causes, and introduce the emerging investigation of minocycline in clinical neurology. The encouraging results of minocycline in experimental neurology bode well for its therapeutic use in human neurological diseases.
Yong
V Wee
VW
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada. vyong@ucalgary.ca
Wells
Jennifer
J
Giuliani
Fabrizio
F
Casha
Steven
S
Power
Christopher
C
Metz
Luanne M
LM
D000818:Animals; D006801:Humans; D008911:Minocycline / Q000627:therapeutic use*; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000473:pathology
D008911:Minocycline