CD4 cell recovery during successful antiretroviral therapy in naive HIV-infected patients: the role of intravenous drug use.
We evaluated the impact of HIV risk practice on immune reconstitution in a prospective cohort of 288 patients (176 former injecting drug users) who maintained complete virus suppression for more than 24 months. Significant differences in CD4 cell counts at 6 and 24 months were detected. Multivariate analysis showed that drug use was an independent predictor of poor immunological recovery. Injection drug abuse impairs short and long-term CD4 cell recovery in HIV-positive patients initiating successful highly active antiretroviral therapy.
Dronda
Fernando
F
Servicio de Enfermedades Infecciosas, and Unidad de Bioestadística Clínica, Hospital Ramón y Cajal. Madrid, Spain.
Zamora
Javier
J
Moreno
Santiago
S
Moreno
Ana
A
Casado
José L
JL
Muriel
Alfonso
A
Pérez-Elías
María J
MJ
Antela
Antonio
A
Moreno
Leonor
L
Quereda
Carmen
C
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D015819:Substance Abuse, Intravenous; D013997:Time Factors; D016896:Treatment Outcome
D019380:Anti-HIV Agents