[Ageing and bone].
Bone loss by ageing has been investigated from standpoints of systemic abnormality and some deficiency in osteoblastic bone formation. This seminar summarize the involvements of a key molecule of adipocytic differentiation PPAR-gamma, essential IGF-I signaling molecules IRS-1 and IRS-2, and an anti-aging gene klotho in the pathophysiology of age-related osteoporosis.
Kawaguchi
Hiroshi
H
Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
D000368:Aged; D000375:Aging / Q000502:physiology*; D005260:Female; D006801:Humans; D010012:Osteogenesis / Q000502:physiology; D010024:Osteoporosis / Q000209:etiology*