On the InterAktion between hexokinase and the mitochondrion.
The protein kinase Akt is now well recognized as a potent inhibitor of apoptosis. Work published by Majewski et al. in the December 3rd issue of Molecular Cell indicates that a major pathway by which Akt suppresses cell death is by stimulating the translocation of hexokinase to the mitochondrion. Hexokinase, in turn, antagonizes the release of mitochondrial cytochrome C.
Birnbaum
Morris J
MJ
Howard Hughes Medical Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 USA.
D000818:Animals; D002470:Cell Survival; D045304:Cytochromes c / Q000378:metabolism*; D006019:Glycolysis; D006593:Hexokinase / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D021381:Protein Transport; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt
D011518:Proto-Oncogene Proteins; D045304:Cytochromes c; D006593:Hexokinase; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D010100:Oxygen