Synthesis and antifungal activity of cholesterol-hydrazone derivatives.
A series of hydrazones synthesized from various cholesterol derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. The activity was highly dependent on the structure of the different compounds involved. The best results have been obtained with tosylhydrazone cholesterol derivatives 8 and 9 exhibiting activities against Candida albicans (CIP 1663-80) at a concentration of 1.5 microg/ml.
Loncle
Céline
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Laboratoire synthèse et étude de substances naturelles à activités biologiques (SESNAB), IMRN INRA 1111, faculté des sciences et techniques de St Jérôme, université Paul Cézanne, Aix-Marseille III, 13397 Marseille 20, France.
Brunel
Jean Michel
JM
Vidal
Nicolas
N
Dherbomez
Michel
M
Letourneux
Yves
Y
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006835:Hydrazones; D002784:Cholesterol