title: Protective efficacy of isometamidium chloride and diminazene aceturate against natural Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population in Uganda.
abstract: The protective efficacy of isometamidium chloride (ISMM) and diminazene aceturate (DIM) against Trypanosoma brucei, Trypanosoma congolense and Trypanosoma vivax infections in cattle under a suppressed tsetse population was assessed in southeast Uganda. A total of 66 and 57 trypanosome-infected cattle were treated with ISMM and DIM, respectively together with 177 trypanosome-free animals not treated were followed for 12 months, checked every 4 weeks. There was no statistical difference in the mean time to infection with any trypanosome species in animals treated with ISMM or DIM. However, the mean time to trypanosome infection was significantly longer for treated animals than controls. The mean time to infection with each of the three trypanosome species differed significantly, with the average time to T. vivax infection the lowest, followed by T. congolense and then T. brucei. The protective efficacy of DIM was as good as that of ISMM; implying curative treatments against trypanosomosis are sufficient for combination with tsetse control. Isometamidium chloride or DIM had the highest impact on T. brucei and T. congolense infections in cattle.
authors.affiliation: Livestock Health Research Institute, Tororo, Uganda. liridir@naro-ug.org
authors.forename: J W
authors.initials: JW
authors.lastname: Magona
authors.forename: J S P
authors.initials: JS
authors.lastname: Mayende
authors.forename: R
authors.initials: R
authors.lastname: Okiria
authors.forename: N M
authors.initials: NM
authors.lastname: Okuna
mesh_terms: D000818:Animals; D002417:Cattle; D004133:Diminazene / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007300:Insect Control; D008297:Male; D010617:Phenanthridines / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D014344:Trypanocidal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014346:Trypanosoma brucei brucei; D014348:Trypanosoma congolense; D016689:Trypanosoma vivax; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D014354:Trypanosomiasis, Bovine / Q000188:drug therapy* / Q000517:prevention & control; D014370:Tsetse Flies / Q000469:parasitology; D014454:Uganda
chemical_list: D010617:Phenanthridines; D014344:Trypanocidal Agents; C000702:isometamidium chloride; C003915:diminazene aceturate; D004133:Diminazene