title: Nicergoline reverts haloperidol-induced loss of detoxifying-enzyme activity.
abstract: We evaluated the effects of nicergoline on antioxidant defense enzymes (detoxifying enzymes), during chronic treatment with haloperidol in rats. Chronic use of haloperidol (10 weeks, 1.5 mg/kg/day) induces a significant decrease in glutathione reductase, glutathione peroxidase and superoxide dismutase activity, in selected areas of the brain. Co-administration of nicergoline (20 days, 10 mg/kg/day) significantly restored the activity of these enzymes to levels comparable to those observed in control rats. These observations suggest beneficial effects of nicergoline in the prevention and in the treatment of haloperidol-induced side effects.
authors.affiliation: Department of Internal Medicine and Therapeutics, University of Pavia, Piazza Botta 10, 27100 Pavia, Italy. vairetti@botta.unipv.it
authors.forename: Mariapia
authors.initials: M
authors.lastname: Vairetti
authors.forename: Andrea
authors.initials: A
authors.lastname: Ferrigno
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Canonico
authors.forename: Angelo
authors.initials: A
authors.lastname: Battaglia
authors.forename: Francantonio
authors.initials: F
authors.lastname: Bertè
authors.forename: Plinio
authors.initials: P
authors.lastname: Richelmi
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002531:Cerebellum / Q000187:drug effects / Q000201:enzymology; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009530:Nicergoline / Q000494:pharmacology*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D010088:Oxidoreductases; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D006220:Haloperidol; D009530:Nicergoline