title: [Treatment of lumbar intervertebral disc displacement with chondroitinase ABC--experimental basis for clinical application].
abstract: After single intradiscal injection of C-ABC in rabbit inter-vertebral discs, water content in the matrix of nucleus pulposus diminished clearly. After similar injection of C-ABC in sheep discs, disc inner pressure was diminished. After single intradiscal injection of C-ABC in dog inter-vertebral discs suffering disc herniation, the syndromes coming from the herniation diminished or disappeared. Based on these observations C-ABC is expected to be a chemonucleolytic agent and a human clinical trial is now in progress.
authors.affiliation: Central Research Laboratories, Seikagaku Corporation.
authors.forename: Toyomi
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D019765:Chondroitin ABC Lyase / Q000008:administration & dosage*; D004285:Dogs; D006801:Humans; D015552:Injections, Intralesional; D007404:Intervertebral Disc Chemolysis; D007405:Intervertebral Disc Displacement / Q000188:drug therapy*; D008159:Lumbar Vertebrae; D011817:Rabbits; D012756:Sheep
chemical_list: D019765:Chondroitin ABC Lyase