title: Apolipoprotein E polymorphism and lipoprotein compositions in patients with Behçet's disease.
abstract: BACKGROUND
  Behçet's disease (BD) is a multisystemic disease of unknown etiology characterized by chronic relapsing oral-genital ulcers and uveitis. Some abnormalities in lipoprotein metabolism have been described in patients with BD.
  
  
  METHODS
  In this study, apolipoprotein E (apo E) polymorphism and lipoprotein cholesterol concentrations in 30 patients with BD were compared with those of 27 control subjects.
  
  
  RESULTS
  Both patients and controls were found to be normolipidemic. Patients with BD had significantly higher concentrations of high-density lipoprotein (HDL) cholesterol than those of controls (P < 0.05); however, there was no difference in serum triglyceride, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol concentrations. The distribution of apo E genotypes and alleles was the same in both groups. There were slight differences in allele frequency between the groups, but this was not statistically significant.
  
  
  CONCLUSIONS
  The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles.
authors.affiliation: Department of Dermatology, University of Mersin School of Medicine, Mersin, Turkey. utursen@mersin.edu.tr
authors.forename: Umit
authors.initials: U
authors.lastname: Tursen
authors.forename: Gulcin
authors.initials: G
authors.lastname: Eskandari
authors.forename: Tamer Irfan
authors.initials: TI
authors.lastname: Kaya
authors.forename: Lulufer
authors.initials: L
authors.lastname: Tamer
authors.forename: Guliz
authors.initials: G
authors.lastname: Ikizoglu
authors.forename: Ugur
authors.initials: U
authors.lastname: Atik
mesh_terms: D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D001528:Behcet Syndrome / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
chemical_list: D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol