title: Structure and functions of the GNAT superfamily of acetyltransferases.
abstract: The Gcn5-related N-acetyltransferases are an enormous superfamily of enzymes that are universally distributed in nature and that use acyl-CoAs to acylate their cognate substrates. In this review, we will examine those members of this superfamily that have been both structurally and mechanistically characterized. These include aminoglycoside N-acetyltransferases, serotonin N-acetyltransferase, glucosamine-6-phosphate N-acetyltransferase, the histone acetyltransferases, mycothiol synthase, protein N-myristoyltransferase, and the Fem family of amino acyl transferases.
authors.affiliation: Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Vetting
authors.forename: Luiz Pedro
authors.initials: LP
authors.lastname: S de Carvalho
authors.forename: Michael
authors.initials: M
authors.lastname: Yu
authors.forename: Subray S
authors.initials: SS
authors.lastname: Hegde
authors.forename: Sophie
authors.initials: S
authors.lastname: Magnet
authors.forename: Steven L
authors.initials: SL
authors.lastname: Roderick
authors.forename: John S
authors.initials: JS
authors.lastname: Blanchard
mesh_terms: D000123:Acetyltransferases / Q000737:chemistry* / Q000378:metabolism*; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D008550:Melatonin / Q000096:biosynthesis; D008958:Models, Molecular; D008961:Models, Structural; D008968:Molecular Conformation; D015394:Molecular Structure; D017433:Protein Structure, Secondary; D013379:Substrate Specificity
chemical_list: D001426:Bacterial Proteins; D005656:Fungal Proteins; D000123:Acetyltransferases; D008550:Melatonin