Born again at the synapse: a new function for the anaphase promoting complex/cyclosome.
Currently, perhaps the most significant biological problem is to understand the mechanisms of learning and memory, and many of the answers will come from molecular explanations of synaptic plasticity. Two new papers have established a surprising connection: the Anaphase Promoting Complex/Cyclosome (APC/C) has a second function in controlling local protein stability at synapses, and hence in the control of behavior .
Zarnescu
Daniela C
DC
Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Room 400, Atlanta, GA 30322 USA.
Moses
Kevin
K
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D001048:Aplysia; D017173:Caenorhabditis elegans; D003593:Cytoplasm / Q000378:metabolism; D004330:Drosophila; D008954:Models, Biological; D013569:Synapses / Q000502:physiology*; D043743:Ubiquitin-Protein Ligase Complexes / Q000737:chemistry* / Q000502:physiology*
D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome