Effect of azithromycin therapy on coronary circulation in patients with coronary artery disease.
This study examined the effect of azithromycin therapy on the coronary microcirculation using measurement of coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography in 35 patients with coronary artery disease. CFVR increased significantly after azithromycin therapy (3.0 +/- 0.7 vs 3.5 +/- 0.7, p <0.001). The changes in CFVR were negatively correlated with changes in high-sensitivity C-reactive protein levels in patients receiving azithromycin.
Hyodo
Eiichi
E
Department of Internal Medicine and Cardiology, Osaka City University School of Medicine, Osaka, Japan.
Hozumi
Takeshi
T
Takemoto
Yasuhiko
Y
Fujimoto
Kohei
K
Watanabe
Hiroyuki
H
Muro
Takashi
T
Shimada
Kenei
K
Akioka
Kaname
K
Yoshiyama
Minoru
M
Takeuchi
Kazuhide
K
Yoshikawa
Junichi
J
D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D017963:Azithromycin / Q000494:pharmacology* / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000150:complications* / Q000188:drug therapy*; D003331:Coronary Vessels / Q000502:physiology; D004311:Double-Blind Method; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium; D011446:Prospective Studies; D012039:Regional Blood Flow
D000900:Anti-Bacterial Agents; D017963:Azithromycin; D002097:C-Reactive Protein