title: [Evaluation of the stability of pertussis vaccine OCO-3 standard].
abstract: The evaluation of the immunogenic activity and residual toxicity of the National Standard of pertussis vaccine (OCO-3) was carried out. As shown by observations lasting for a period of 25 years, the preparation possesses stable immunogenicity and its toxicity remained unchanged, which makes it possible to use OCO-3 for the routine control of the pertussis component of commercial lots of adsorbed DPT vaccine.
authors.forename: R P
authors.initials: RP
authors.lastname: Chuprinina
authors.forename: I A
authors.initials: IA
authors.lastname: Alekseeva
mesh_terms: D000818:Animals; D017849:Animals, Inbred Strains; D001835:Body Weight; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D007274:Injections, Intraperitoneal; D051379:Mice; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000592:standards* / Q000633:toxicity; D014611:Vaccination / Q000592:standards*; D014917:Whooping Cough / Q000517:prevention & control*
chemical_list: D010567:Pertussis Vaccine