[Argyrophilic proteins of nucleolar organizers regions as markers of malignancy grade of anaplastic large-cell lymphoma and Hodgkin's lymphoma].
Expression of argyrophilic proteins of nucleolar organizers regions (Ag-NOR-proteins) was studied in tumor cells from 17 patients with a classic variant of anaplastic large-cell lymphoma (ALCL) and 22 patients with Hodgkin's lymphoma (HL). Eight cases of p80+ and nine cases of p80-ALCL were studied. HL was represented by 13 cases with lymphoid depletion by a reticular type and 9 cases with nodular sclerosis with a syncytial growth. Ag-NOR-proteins were identified using histochemical method with silver nitrate. The expression of Ag-NOR-proteins in tumor cells of ALCL and HL appeared intensive, being highest in ALCL cells, in p80+ cells of ALCL there was superexpression. The differences in expression of Ag-NOR-proteins point to different proliferative activity and growth of the above variants of ALCL and HL. The test for Ag-NOR-proteins expression can be recommended as an additional tool in differential diagnosis, determination of malignancy grade, assesssment of prognosis and sensitivity to chemotherapy.
Raĭkhlin
N T
NT
Bukaeva
I A
IA
Probatova
N A
NA
Smirnova
E A
EA
Pavlovskaia
A I
AI
Tupitsin
N N
NN
Sholokhova
E N
EN
Osmanov
Sh Sh
ShSh
D015703:Antigens, CD / Q000378:metabolism; D034961:Antigens, Nuclear / Q000096:biosynthesis; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002455:Cell Division; D003937:Diagnosis, Differential; D006689:Hodgkin Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000096:biosynthesis; D009697:Nucleolus Organizer Region / Q000378:metabolism* / Q000473:pathology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism
D015703:Antigens, CD; D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; C051963:nucleolar organizer region associated proteins; C107023:p80(NPM-ALK) protein; D011505:Protein-Tyrosine Kinases