A bioactive biflavonoid from Campnosperma panamense.
Lanaroflavone (1), a biflavonoid isolated from the methanol extract of the aerial part of Campnosperma panamense by bioguided fractionation, has been assessed for in vitro antiprotozoal activity. Lanaroflavone showed both antimalarial and leishmanicidal activities, but was inactive against Chagas disease vector, Trypanosoma cruzi.
Weniger
B
B
Laboratoire de Pharmacognosie, UMR 7081, Faculté de Pharmacie, Université Louis Pasteur, BP 60024, 67401 Strasbourg, France. weniger@pharma.u-strasbg.fr
Vonthron-Sénécheau
C
C
Arango
G J
GJ
Kaiser
M
M
Brun
R
R
Anton
R
R
D027926:Anacardiaceae; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014355:Chagas Disease / Q000188:drug therapy; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
D000962:Antimalarials; D000981:Antiprotozoal Agents; D005419:Flavonoids; D010936:Plant Extracts; D014344:Trypanocidal Agents