Intestinal transport of an obdurate anion: oxalate.
In this review, we focus on the role of gastrointestinal transport of oxalate primarily from a contemporary physiological standpoint with an emphasis on those aspects that we believe may be most important in efforts to mitigate the untoward effects of oxalate. Included in this review is a general discussion of intestinal solute transport as it relates to oxalate, considering cellular and paracellular avenues, the transport mechanisms, and the molecular identities of oxalate transporters. In addition, we review the role of the intestine in oxalate disease states and various factors affecting oxalate absorption.
Hatch
Marguerite
M
Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, P.O. Box 100275, 1600 S.W. Archer Road, FL 32610, USA. hatchma@ufl.edu
Freel
Robert W
RW
D000818:Animals; D000838:Anions / Q000378:metabolism*; D001692:Biological Transport; D004195:Disease Models, Animal; D041981:Gastrointestinal Tract / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000382:microbiology; D010070:Oxalates / Q000378:metabolism*; D020624:Oxalobacter formigenes / Q000502:physiology
D000838:Anions; D010070:Oxalates