title: Suppressive effect of antibiotic siomycin on antibody production.
abstract: The antibiotic thiazole compound siomycin, which we have found from the culture broth of Actinomycetes (strain No.806097) in search of antibody production inhibitor, showed the in vitro immunosuppressive property against B-cells stimulated with T-cell independent antigen DNP-LPS (dinitrophenyl-lipopolysaccharide) while it also showed inhibitory effect against T-cell proliferation. Its inhibitory mechanism was considered to be different from that of FK506, the representative of T-cell immunosuppressant. Moreover, siomycin showed inhibitory effect in both T-cell dependent and independent murine antibody production models and decreased the severity in murine collagen arthritis model. Therefore, siomycin is a unique immunosuppressant which has potential for the treatment of some antibody-mediated diseases.
authors.affiliation: Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. motoi_ueno@po.fujisawa.co.jp
authors.forename: Motoi
authors.initials: M
authors.lastname: Ueno
authors.forename: Satoko
authors.initials: S
authors.lastname: Furukawa
authors.forename: Fumie
authors.initials: F
authors.lastname: Abe
authors.forename: Michiko
authors.initials: M
authors.lastname: Ushioda
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fujine
authors.forename: Shigeru
authors.initials: S
authors.lastname: Johki
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Hatori
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueda
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000917:Antibody Formation / Q000187:drug effects*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D001402:B-Lymphocytes / Q000276:immunology; D003094:Collagen; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D010455:Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology; D016559:Tacrolimus / Q000494:pharmacology / Q000627:therapeutic use; D013883:Thiostrepton / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D010455:Peptides; C025311:siomycin; D003094:Collagen; D013883:Thiostrepton; D016559:Tacrolimus