title: In vitro activities of OPT-80 and comparator drugs against intestinal bacteria.
abstract: The activities of OPT-80 against 453 intestinal bacteria were compared with those of seven other drugs. OPT-80 showed good activity against most clostridia, staphylococci, and enterococci, but streptococci, aerobic and facultative gram-negative rods, anaerobic gram-negative rods, and Clostridium ramosum were resistant. Poor activity against anaerobic gram-negative rods may maintain colonization resistance.
authors.affiliation: Medical Service, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA. sidfinegol@aol.com
authors.forename: Sydney M
authors.initials: SM
authors.lastname: Finegold
authors.forename: Denise
authors.initials: D
authors.lastname: Molitoris
authors.forename: Marja-Liisa
authors.initials: ML
authors.lastname: Vaisanen
authors.forename: Yuli
authors.initials: Y
authors.lastname: Song
authors.forename: Chengxu
authors.initials: C
authors.lastname: Liu
authors.forename: Mauricio
authors.initials: M
authors.lastname: Bolaños
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D005243:Feces / Q000382:microbiology; D006027:Glycosides / Q000494:pharmacology*; D007422:Intestines / Q000187:drug effects / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D006027:Glycosides; C487655:OPT 80