[Role of vitamin D in the pathogenesis of renal osteodystrophy].
Renal osteodystrophy was occurred in patients with chronic renal failure and the biopsied patients had various forms of bone disease. Active vitamin D has an important role of calcium regulation and bone metabolism. In patients with end-stage renal disease, decreased levels of active vitamin D, reduced number of vitamin D receptors and calcium sensing receptors in parathyroid gland pay a major role in the development of hyperparathyroidism. It was invited osteitis fibrosa, high bone turnover. The parathyroid function is suppressed by active vitamin D, it was considered that lower parathyroid hormone levels was one of the cause of low bone turnover, adynamic bone disease.
Nakanishi
Shohei
S
The Nephrology Center, Toranomon Hospital.
Fukagawa
Masafumi
M
D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology*; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000378:metabolism; D010002:Osteitis Fibrosa Cystica / Q000209:etiology; D010018:Osteomalacia / Q000209:etiology; D010280:Parathyroid Glands / Q000378:metabolism / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000502:physiology; D018167:Receptors, Calcitriol / Q000378:metabolism; D044169:Receptors, Calcium-Sensing / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism / Q000502:physiology*
D010281:Parathyroid Hormone; D018167:Receptors, Calcitriol; D044169:Receptors, Calcium-Sensing; D014807:Vitamin D; D002118:Calcium