New norditerpenoids with trypanocidal activity from Vitex trifolia.
Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 microM (1), 36 microM (2), 34 microM (3), 34 microM (4), 66 microM (5), 66 microM (6), and >265 microM (7).
Kiuchi
Fumiyuki
F
Tsukuba Medicinal Plant Research Station, National Institute of Health Sciences, Hachiman-dai, Tsukuba, Japan.
Matsuo
Kenji
K
Ito
Michiho
M
Qui
Tran Kim
TK
Honda
Gisho
G
D000818:Animals; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D005638:Fruit / Q000737:chemistry; D010084:Oxidation-Reduction; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014344:Trypanocidal Agents / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D014349:Trypanosoma cruzi / Q000187:drug effects; D020950:Vitex / Q000737:chemistry*
D004224:Diterpenes; D014344:Trypanocidal Agents