[Study on the compatibility of composite herbal medicines of the Zishen pill].
OBJECTIVE
To study the compatibility of composite herbal medicines of the Zishen pill.


METHODS
50% ethanol extract test solution of the different combinations of composite herbal medicines of the Zishen pill were prepared. Pharmacologic experiments, such as anti-inflammatory, carbon particle clearance of RES were carried out with the solutions, and the corresponding pharmacological data were obtained. Variance analysis, canonical correlation and stepwise regression analysis were applied to interrelate the amount of each drug and the pharmacological data.


RESULTS
The results confirmed that Huangbo and Zhimu were the basis, while Rougui was the corrigent, which was conformed to the theory of TCM.


CONCLUSIONS
This study provides a significant try for studying the compatibility of composite herbal medicines.
Dai
Rong-hua
RH
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhang
Yuan-yuan
YY
Bi
Kai-shun
KS
D031403:Anemarrhena / Q000737:chemistry; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002244:Carbon / Q000493:pharmacokinetics; D027424:Cinnamomum / Q000737:chemistry; D004338:Drug Combinations; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004423:Ear / Q000473:pathology; D004427:Ear Diseases / Q000473:pathology; D004487:Edema / Q000473:pathology; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D051379:Mice; D032102:Phellodendron / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D002244:Carbon