title: Scoring atopic dermatitis in infants and young children: distinctive features of the SCORAD index.
abstract: BACKGROUND
  Atopic dermatitis (AD) affects infants, children, and adults with a wide degree of severity; several scoring systems have been used in trials and clinical practice. Infants and young children have a typical distribution of the lesions, but a correlation among skin surface involvement, intensity and subjective symptoms has not been reported in age groups.
  
  
  OBJECTIVE
  To evaluate the clinical features of AD in infants and young children, by using the SCORAD index. A simplified scoring method for clinical practice is also discussed.
  
  
  METHODS
  The SCORAD index was assessed in 63 infants and young children with AD [mean age (+/-SD) 17.5 +/- 11.15 months]; the single parameters of the index were evaluated, and compared with each other. Serum eosinophil cationic protein (s-ECP) and urinary eosinophil protein X (u-EPX) levels were determined and correlated with the SCORAD index.
  
  
  RESULTS
  The presence of erythema, edema/papulation, and oozing/crust was significantly high in these patients. A strong positive correlation resulted among the three SCORAD index parameters (extent-intensity: P <0.001; extent-subjective symptoms: P <0.001; intensity-subjective symptoms: P <0.001). S-ECP and u-EPX levels positively correlated to almost every single parameter of the SCORAD index as well as to its total.
  
  
  CONCLUSIONS
  Distinctive intensity items were found in infants and young children with AD. A strong correlation resulted among the extent, intensity, and subjective symptoms; each of the three parameters was positively correlated with the total SCORAD. Immunologic parameters positively correlated to each of the SCORAD index items, which remains the gold standard for assessing disease severity in clinical trials.
authors.affiliation: Allergy and Clinical Immunology Unit, Department of Paediatrics, Anna Meyer Children's Hospital, University of Florence, Florence, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Pucci
authors.forename: E
authors.initials: E
authors.lastname: Novembre
authors.forename: M G
authors.initials: MG
authors.lastname: Cammarata
authors.forename: R
authors.initials: R
authors.lastname: Bernardini
authors.forename: M G
authors.initials: MG
authors.lastname: Monaco
authors.forename: C
authors.initials: C
authors.lastname: Calogero
authors.forename: A
authors.initials: A
authors.lastname: Vierucci
mesh_terms: D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood / Q000473:pathology* / Q000652:urine; D004487:Edema / Q000473:pathology; D047150:Eosinophil Cationic Protein / Q000097:blood; D047208:Eosinophil-Derived Neurotoxin / Q000652:urine; D004890:Erythema / Q000473:pathology; D006801:Humans; D007223:Infant; D012720:Severity of Illness Index
chemical_list: D047208:Eosinophil-Derived Neurotoxin; D047150:Eosinophil Cationic Protein; C479220:RNASE3 protein, human