[Neuroprotector action of an asparagic acid derivative during the model reperfusive cerebral damage in cats].
Neuroprotector properties of a new phosphorylated derivative of asparagic acid (PIR 87-65-0) were studied on a model of acute brain ischemia in cats. PIR 87-5-0 has proved to be more effective than the reference drug vinpocetin in preventing the reperfusive damage, which was manifested by decreased postischemic hypergycemia, activated utilization of oxygen and glucose in the brain, and suppressed postischemic metabolic lactate acidosis.
Makarova
L P
LP
Pogorelyĭ
V E
VE
D000818:Animals; D001224:Aspartic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D001930:Brain Injuries / Q000150:complications / Q000378:metabolism / Q000517:prevention & control; D002545:Brain Ischemia / Q000150:complications / Q000378:metabolism; D002415:Cats; D005947:Glucose / Q000378:metabolism; D006943:Hyperglycemia / Q000188:drug therapy / Q000209:etiology; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D010101:Oxygen Consumption / Q000187:drug effects; D015427:Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*
D018696:Neuroprotective Agents; D001224:Aspartic Acid; D005947:Glucose