Molecular design of artificial ribonucleases using electrostatic interaction.
A number of small organic ribonucleases have been synthesized with rigid polycationic structures containing an aromatic framework with two residues of bis-quaternary salts of 1,4-diazabicyclo[2.2.2]octane (DABCO) bearing various substituents. The compounds carrying positively charged groups connected via rigid linker are expected to bend the sugar-phosphate backbone and can stimulate the intramolecular phosphoester transfer reaction.
Burakova
Ekaterina A
EA
Novosibirsk Institute of Bioorganic Chemistry, Novosibirsk, Russia.
Silnikov
Vladimir N
VN
D010879:Piperazines / Q000737:chemistry; D012260:Ribonucleases / Q000138:chemical synthesis* / Q000737:chemistry; D055672:Static Electricity
D010879:Piperazines; D012260:Ribonucleases; C007306:triethylenediamine