Tumid lupus erythematosus occurring following highly active antiretroviral therapy for HIV infection: a manifestation of immune restoration.
Tumid lupus erythematosus (LE) is a relatively rare and only recently recognized subset of chronic cutaneous lupus. We report a case occurring in a male with HIV infection whereby his rash was only unmasked by immune restoration following highly active antiretroviral therapy (HAART). The phenomenon of latent inflammatory or autoimmune disease appearing following HAART is now recognized as the "immune restoration syndrome" and tumid LE has not been reported in this setting previously. Fortunately this variant of lupus does not result in scarring and is responsive to anti-malarials, allowing continuation of HAART in this patient.
Chamberlain
Alexander J
AJ
Department of Dermatology, Oxford Radcliffe Hospitals, Oxford, United Kingdom. richard.turner@orh.nhs.uk
Hollowood
Kevin
K
Turner
Richard J
RJ
Byren
Ivor
I
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D003879:Dermatologic Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007121:Immunocompetence; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy / Q000276:immunology*; D008297:Male
D003879:Dermatologic Agents; D006886:Hydroxychloroquine