Comparative study on the modulation of IgE and cytokine production by Phellinus linteus grown on germinated brown Rice, Phellinus Linteus and germinated brown rice in murine splenocytes.
We compared the immunomodulating activities in mice of extracts from Phellinus linteus grown on germinated brown rice (PB), Phellinus linteus (PL) alone, and germinated brown rice (BR) alone. The PL, BR and PB-treated mice were administered with the respective extract (2 mg/head/day) by oral gavage for 4 weeks. All extracts markedly decreased the IgE production and allergic responses in serum and splenocytes. PL and PB increased the proportion of CD4(+) but not CD8(+) T cells in splenocytes. Cytokine production was significantly augmented in all treated mice; the concentration of IFN-gamma was greater in the PL, BR and PB mice than in the control group. The concentration of IL-10 was lower in the BR group than in the other groups. These results may be related to the suppression of IgE production. We conclude that PB modulated the immune responses of IgE production and Th1/Th2 cytokine secretion in murine splenocytes.
Lim
Beong Ou
BO
Department of Life Science, Konkuk University, Chungbuk, Korea. beongou@kku.ac.kr
Yamada
Koji
K
Cho
Bong-Gum
BG
Jeon
Taeil
T
Hwang
Seong-Gu
SG
Park
Taekyu
T
Kang
Soon Ah
SA
Park
Dong Ki
DK
D000818:Animals; D001487:Basidiomycota / Q000378:metabolism*; D015704:CD4 Antigens / Q000378:metabolism; D016827:CD8 Antigens / Q000378:metabolism; D003470:Culture Media; D016207:Cytokines / Q000096:biosynthesis*; D004435:Eating / Q000187:drug effects; D018525:Germination; D007073:Immunoglobulin E / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012275:Oryza / Q000378:metabolism*; D013154:Spleen / Q000166:cytology / Q000378:metabolism*; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
D015704:CD4 Antigens; D016827:CD8 Antigens; D003470:Culture Media; D016207:Cytokines; D007073:Immunoglobulin E