[BMP and bone formation].
Bone Morphogenetic Proteins (BMPs) are secreted proteins that represent a group of the transforming growth factor-beta. BMPs were identified as molecules that induce ectopic bone formation in muscles of mice. The homo- or heterodimetric BMP proteins, which bind to serine/threonine protein-kinase receptor and activate smad and p38MAPK signal transductions, function as potent osteogenic factors. In vivo, it is not clear which BMPs play crucial roles in regulating osteogenesis. Clinical uses of rhBMP-2 and rhBMP-7 have been performed, but we need numerous rhBMPs, which is very expensive, to induce osteogenesis in humans.
Kugimiya
Fumitaka
F
Department of Orthopaedic Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Kawaguchi
Hiroshi
H
Chung
Ung-Il
UI
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D010012:Osteogenesis / Q000187:drug effects
D019485:Bone Morphogenetic Proteins