[Tumor multidrug-resistance and reversing actions of traditional Chinese medicine].
Tumor multidrug-resistance (MDR) is a major factor in chemotherapeutic failure. In recent years, the development of anti-MDR has become an important focus in research. The mechanisms of MDR relate to P-glycoprotein, MRP1, apoptosis, the unusual DNA repair, the organic micro-environment, and so on. This review summarized the advances in MDR mechanism research. At the same time, it summarized the recent research of traditional Chinese medicine in reversing MDR. Furthermore, their mechanisms and major features of actions were also discussed.
Feng
Jun-dong
JD
College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, 400050, China. fengjun-dong2001@sohu.com
Xu
Xiao-yu
XY
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D004260:DNA Repair / Q000187:drug effects; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004365:Drugs, Chinese Herbal; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C421109:multidrug resistance-associated protein 1