Association of the intestinal fatty acid-binding protein Ala54Thr polymorphism and abdominal adipose tissue in African-American and Caucasian women.
Genetic variants in the intestinal fatty acid-binding protein-2 (FABP2) gene have been associated with body composition phenotypes. We examined the association between the Ala(54)Thr variant in the FABP2 gene and levels of visceral (VAT) and sc (SAAT) abdominal fat in a group of 223 premenopausal African-American (n = 103) and Caucasian (n = 120) women. Subjects were genotyped for the marker. In addition, body composition was assessed by dual energy x-ray absorptiometry, and VAT was determined from a single computed tomography scan. The frequency of the Thr mutant allele did not differ significantly by ethnic group. After adjusting for total body fat, total abdominal adipose tissue (TAT) and SAAT were significantly lower in carriers of either one or two copies of the mutant Thr allele (P < 0.01). There was no association between total fat mass or VAT and the FABP2 polymorphism. Separate analyses by ethnic group showed that the association between the polymorphism and TAT and SAAT was observed in Caucasian (P < 0.01), but not in African-American (not significant), women. We conclude that women carriers of the FABP2 Thr allele have lower TAT and SAAT than noncarriers of the mutation. This association is present in Caucasian, but not in African-American, women.
Lara-Castro
Cristina
C
Department of Nutrition Sciences, University of Alabama, Birmingham, Alabama 35294, USA. larac@uab.edu
Hunter
Gary R
GR
Lovejoy
Jennifer C
JC
Gower
Barbara A
BA
Fernández
José R
JR
D000005:Abdomen; D000273:Adipose Tissue / Q000033:anatomy & histology*; D000328:Adult; D019943:Amino Acid Substitution; D001415:Back; D001823:Body Composition; D015992:Body Mass Index; D002352:Carrier Proteins / Q000235:genetics*; D017931:DNA Primers; D050556:Fatty Acid-Binding Proteins; D005260:Female; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017697:Premenopause; D014481:United States; D044465:White People
D002352:Carrier Proteins; D017931:DNA Primers; C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins