Antibacterial activity of naphthoquinones and triterpenoids from Euclea natalensis root bark.
Phytochemical studies of an ethanolic extract of Euclea natalensis root bark afforded two new compounds, octahydroeuclein (1) and 20(29)-lupene-3 beta-isoferulate (2), in addition to three known compounds, shinanolone (3), lupeol, and betulin. The chemical structures of 1 and 2 were determined by spectroscopic means. Shinanolone (3) showed inhibitory activity against Gram-positive bacterial strains and a drug-sensitive strain of Mycobacterium tuberculosis at a concentration of 0.1 mg/mL.
Weigenand
Oliver
O
Department of Botany, University of Pretoria, 0002 Pretoria, South Africa.
Hussein
Ahmed A
AA
Lall
Namrita
N
Meyer
Jacobus J M
JJ
D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D031262:Ebenaceae / Q000737:chemistry*; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D013019:South Africa; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000094042:Lupanes; D000094062:Betulinic Acid
D000995:Antitubercular Agents; D009285:Naphthoquinones; D014315:Triterpenes; C495017:20(29)-lupene-3 beta-isoferulate; D000094042:Lupanes; C495015:octahydroeuclein; C495016:shinanolone; C002503:betulin; D000094062:Betulinic Acid