title: Novel paramagnetic contrast agents for molecular imaging and targeted drug delivery.
abstract: Molecular biology and genomic sciences are revealing the early biological signatures for many diseases. In response, the Molecular Imaging community is rapidly developing contrast agents to visualize the nascent pathological changes and to concomitantly deliver treatment directly to the site of disease. The evaluation, development and use of these new agents require a complementary understanding of contrast chemistry and imaging techniques. The fundamental issues surrounding magnetic contrast agent development, rational drug delivery, MR molecular imaging, and their interdependence are elucidated.
authors.affiliation: Division of Cardiology, Campus Box 8086, Washington University Medical School, 600 S. Euclid Ave, Saint Louis, MO 63110, USA. greg@cvu.wustl.edu
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Lanza
authors.forename: Patrick
authors.initials: P
authors.lastname: Winter
authors.forename: Shelton
authors.initials: S
authors.lastname: Caruthers
authors.forename: Anne
authors.initials: A
authors.lastname: Schmeider
authors.forename: Kathy
authors.initials: K
authors.lastname: Crowder
authors.forename: Anne
authors.initials: A
authors.lastname: Morawski
authors.forename: Huiying
authors.initials: H
authors.lastname: Zhang
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Scott
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Wickline
mesh_terms: D000818:Animals; D001704:Biopolymers / Q000032:analysis / Q000378:metabolism*; D003287:Contrast Media; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D008967:Molecular Biology / Q000379:methods; D015336:Molecular Probe Techniques; D015335:Molecular Probes; D043942:Nanotubes / Q000737:chemistry / Q000648:ultrastructure
chemical_list: D001704:Biopolymers; D003287:Contrast Media; D015335:Molecular Probes