title: CD4 cell recovery during successful antiretroviral therapy in naive HIV-infected patients: the role of intravenous drug use.
abstract: We evaluated the impact of HIV risk practice on immune reconstitution in a prospective cohort of 288 patients (176 former injecting drug users) who maintained complete virus suppression for more than 24 months. Significant differences in CD4 cell counts at 6 and 24 months were detected. Multivariate analysis showed that drug use was an independent predictor of poor immunological recovery. Injection drug abuse impairs short and long-term CD4 cell recovery in HIV-positive patients initiating successful highly active antiretroviral therapy.
authors.affiliation: Servicio de Enfermedades Infecciosas, and Unidad de Bioestadística Clínica, Hospital Ramón y Cajal. Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Dronda
authors.forename: Javier
authors.initials: J
authors.lastname: Zamora
authors.forename: Santiago
authors.initials: S
authors.lastname: Moreno
authors.forename: Ana
authors.initials: A
authors.lastname: Moreno
authors.forename: José L
authors.initials: JL
authors.lastname: Casado
authors.forename: Alfonso
authors.initials: A
authors.lastname: Muriel
authors.forename: María J
authors.initials: MJ
authors.lastname: Pérez-Elías
authors.forename: Antonio
authors.initials: A
authors.lastname: Antela
authors.forename: Leonor
authors.initials: L
authors.lastname: Moreno
authors.forename: Carmen
authors.initials: C
authors.lastname: Quereda
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D015819:Substance Abuse, Intravenous; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents