title: Efficacy and safety of argon plasma coagulation for the treatment of hemorrhagic radiation proctitis.
abstract: OBJECTIVE
  To evaluate the efficacy, safety and medium-/long-term clinical course of patients undergoing endoscopic treatment with argon plasma coagulation for hemorrhagic radiation proctopathy.
  
  
  METHODS
  Descriptive, retrospective study with medium- and long-term follow-up.
  
  
  METHODS
  Ten patients were treated with argon plasma coagulation for hemorrhagic radiation proctopathy between July 1998 and February 2003. Inclusion criteria were: evidence of chronic rectal bleeding, consistent endoscopic findings, and absence of any other cause of hematochezia after a comprehensive ano-rectal examination and complete colonoscopy. The equipment used was a standard colonoscope, an argon delivery unit, an argon plasma coagulation probe 1.5 mm in internal diameter, and a high-frequency electrosurgical generator. Consecutive treatment sessions were programmed whenever it was considered necessary until all mucosal lesions had been treated. Clinical and evolutive follow-up was performed with a focus on tolerance, efficacy, and potential argon plasma coagulation-related complications. Data were updated by personal or telephonic interview.
  
  
  RESULTS
  In all patients, chronic rectal bleeding stopped after the last treatment session. The mean number of treatment sessions to stop symptoms was 1.7. Mean follow-up was 31.1 months. All sessions were well tolerated, similarly to standard rectoscopy. In one case a recurrence of rectal bleeding was observed four months later, which required two repeat sessions. Four patients were anemic at inclusion. Three of them reported a resolved anemia at the end of the study. No delayed argon plasma coagulation-related complications such us ulcers or strictures were seen.
  
  
  CONCLUSIONS
  Argon plasma coagulation appears to be a useful, effective and safe treatment for rectal bleeding resulting from chronic radiation proctitis when compared to standard medical and endoscopic treatments. These successful outcomes seem to persist even after long-term follow-up.
authors.affiliation: Unidad de Aparato Digestivo, Hospital Virgen de la Concha, Zamora, Spain. csernah@hotmail.com
authors.forename: C
authors.initials: C
authors.lastname: de la Serna Higuera
authors.forename: Mi
authors.initials: M
authors.lastname: Martín Arribas
authors.forename: Sj
authors.initials: S
authors.lastname: Rodríguez Gómez
authors.forename: A
authors.initials: A
authors.lastname: Pérez Villoria
authors.forename: J
authors.initials: J
authors.lastname: Martínez Moreno
authors.forename: A
authors.initials: A
authors.lastname: Betancourt González
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy; D000368:Aged; D001128:Argon; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000601:surgery*; D016558:Hemostasis, Endoscopic / Q000379:methods; D006801:Humans; D017075:Laser Coagulation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000532:radiotherapy; D011349:Proctitis / Q000209:etiology / Q000601:surgery*; D011832:Radiation Injuries / Q000150:complications / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies; D012449:Safety; D016896:Treatment Outcome
chemical_list: D001128:Argon