title: [A case of advanced colon cancer responding completely to systemic 5-fluorouracil/l-leucovorin therapy].
abstract: A 79-year-old man was admitted for advanced transverse colon cancer with large bowel obstruction. Twelve years earlier he underwent a total gastrectomy with Roux-en Y reconstruction for gastric cancer. No metastasis was detected preoperatively. Exploratory laparotomy revealed massive direct invasion of the mesenterium of the jejunum for Roux-en Y reconstruction. The primary lesion was unresected and transverse colostomy was made. Systemic chemotherapy with 5-fluorouracil and l-leucovorin was scheduled for a total of 4 courses postoperatively. After completion of this chemotherapeutic regimen, a CT scan and colonofiberscopy revealed the primary lesions had disappeared, and a histological examination of biopsy confirmed that the patient had achieved a complete remission (CR). There was no severe side effect during chemotherapy. The patient is presently enjoying a good general condition and has been free from any sign of recurrence.
authors.affiliation: Dept. of Surgery, Rinku General Medical Center, Izumisano Municipal Hospital.
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Mizushima
authors.forename: Kinya
authors.initials: K
authors.lastname: Sando
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Ito
authors.forename: Shoki
authors.initials: S
authors.lastname: Mikata
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nonaka
authors.forename: Haruki
authors.initials: H
authors.lastname: Ide
authors.forename: Toshiya
authors.initials: T
authors.lastname: Michiura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kainuma
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yamanaka
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Iwase
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003125:Colostomy; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D009361:Neoplasm Invasiveness
chemical_list: D002955:Leucovorin; D005472:Fluorouracil