Ganoderma lucidum suppresses endothelial cell cytotoxicity and proteinuria in persistent proteinuric focal segmental glomerulosclerosis (FSGS) nephrosis.
A persistent proteinuria is commonly observed in nephrotic patient with focal segmental glomerulosclerosis (FSGS) under treatment with prednisolone+/-cyclophosphamide or with vasodilators (ACEI+AII receptor antagonist, calcium channel blocker and antiplatelet agent). Fourteen such patients with persistent proteinuria were subject to be treated with Ganoderma lucidum. Initial study revealed an enhanced endothelial cell cytotoxicity induced by patient's serum, and an altered immunocirculatory balance with predominant proinflammatory cytokine TNF alpha activity in the presence of defective anti-inflammatory cytokine interleukin-10. Treatment with Ganoderma lucidum suppressed endothelial cell cytotoxicity, restored immunocirculatory balance and successfully suppressed proteinuria in all of these 14 patients.
Futrakul
Narisa
N
Department of Physiology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. fmednft@md2.md.chula.ac.th
Panichakul
Tasanee
T
Butthep
Punnee
P
Futrakul
Prasit
P
Jetanalin
Pim
P
Patumraj
Suthiluk
S
Siriviriyakul
Prasong
P
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D016923:Cell Death; D003520:Cyclophosphamide / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood / Q000187:drug effects / Q000276:immunology; D004359:Drug Therapy, Combination; D042783:Endothelial Cells / Q000187:drug effects / Q000473:pathology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy*; D006801:Humans; D009395:Nephritis, Interstitial; D009401:Nephrosis / Q000188:drug therapy; D008517:Phytotherapy / Q000379:methods*; D010946:Plants, Medicinal; D011239:Prednisolone / Q000627:therapeutic use; D011507:Proteinuria / Q000188:drug therapy*; D020940:Reishi; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D014665:Vasodilator Agents; D003520:Cyclophosphamide; D011239:Prednisolone