title: Hepatic arterial infusion of paclitaxel for liver metastasis from gastric cancer.
abstract: Little is known about hepatic arterial infusion (HAI) of paclitaxel for hepatic malignancies. The authors administered paclitaxel via the HAI port in two patients with liver metastases from gastric cancer. Both patients were uneventfully treated without any serious complications, and its anti-tumor effect on 5-fluouracil resistant liver metastases was confirmed. However, the kinetics of venous paclitaxel concentration following HAI was similar to that after intravenous injection. Our findings did not support the advantage of paclitaxel HAI therapy, although HAI of this agent was well tolerated.
authors.affiliation: Department of Surgery, NTT West Osaka Hospital, Osaka, Japan. t.tono@zero.ad.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tono
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwazawa
authors.forename: Shigeo
authors.initials: S
authors.lastname: Matsui
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yano
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kimura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kanoh
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nakano
authors.forename: Jun
authors.initials: J
authors.lastname: Okamura
authors.forename: Takushi
authors.initials: T
authors.lastname: Monden
mesh_terms: D000328:Adult; D000368:Aged; D004341:Drug Evaluation; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000556:secondary*; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D017239:Paclitaxel