Determination of lipoic acid in dietary supplement preparations by capillary electrophoresis.
The present study deals with the development of a method for the quantitative determination of lipoic acid in a dietary supplement preparation. A rapid capillary electrophoretic method is developed using UV detection at 208 nm. Although lipoic acid is only weakly UV-absorbing, at this wavelength it could be detected with sufficient sensitivity with an LOD and LOQ of 0.8 and 2.5 microg/ml, respectively. Analysis time was less than 9 min. The compound was extracted from tablets with a recovery of 98.3% and a precision of 2.8% RSD.
Sitton
Alberto
A
Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, Karl-Franzens University, Univ. Pl.1, Graz 8010, Austria.
Schmid
Martin G
MG
Gübitz
Gerald
G
Aboul-Enein
Hassan Y
HY
D019587:Dietary Supplements / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D005504:Food Analysis / Q000379:methods*; D008832:Microchemistry / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D008063:Thioctic Acid / Q000032:analysis*
D008063:Thioctic Acid