Chemical constituents from the Colombian medicinal plant Maytenus laevis.
The methanol extract of the bark of the Colombian medicinal plant Maytenus laevis gave six new compounds and 28 known compounds. The structures of the new and known compounds were elucidated on the basis of spectroscopic evidence. Several of these compounds were screened for cytokine-inducing activity on human PBMCs to investigate antitumor effects, and canophyllol (12) demonstrated the most effective induction of the cytokines.
Nakagawa
Hiroyuki
H
Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi, Tokushima 770-8505, Japan.
Takaishi
Yoshihisa
Y
Fujimoto
Yoshinori
Y
Duque
Carmenza
C
Garzon
Cristina
C
Sato
Mitsunobu
M
Okamoto
Masato
M
Oshikawa
Tetsuya
T
Ahmed
Sharif Uddin
SU
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003105:Colombia; D016207:Cytokines / Q000096:biosynthesis; D004354:Drug Screening Assays, Antitumor; D006680:HLA Antigens; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D029755:Maytenus / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D016207:Cytokines; D006680:HLA Antigens