title: Heart rate recovery after exercise: a predictor of ventricular fibrillation susceptibility after myocardial infarction.
abstract: Heart rate recovery after exercise, thought to be related to cardiac parasympathetic tone, has been shown to be a prognostic tool for all-cause mortality. However, the relationship between this variable and confirmed susceptibility to ventricular fibrillation (VF) has not been established. Therefore, myocardial ischemia was induced with a 2-min occlusion of the left circumflex artery during the last minute of exercise in mongrel dogs with myocardial infarction (n = 105 dogs). VF was induced in 66 animals (susceptible), whereas the remaining 39 dogs had no arrhythmias (resistant). On a previous day, ECG was recorded and a time-series analysis of heart rate variability was measured 30, 60, and 120 s after submaximal exercise (treadmill running). The heart rate recovery was significantly greater in resistant dogs than in susceptible dogs at all three times, with the most dramatic difference at the 30-s mark (change from maximum: 48.1 +/- 3.6 beats/min, resistant dogs; 31.0 +/- 2.2 beats/min, susceptible dogs). Correspondingly, indexes of parasympathetic tone increased to a significantly greater extent in resistant dogs at 30 and 60 s after exercise. These differences were eliminated by atropine pretreatment. When considered together, these data suggest that resistant animals exhibit a more rapid recovery of vagal activity after exercise than those susceptible to VF. As such, postexercise heart rate recovery may help identify patients with a high risk for VF following myocardial infarction.
authors.affiliation: Dept. of Physiology and Cell Biology, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210-1218, USA.
authors.forename: Lauren L
authors.initials: LL
authors.lastname: Smith
authors.forename: Monica
authors.initials: M
authors.lastname: Kukielka
authors.forename: George E
authors.initials: GE
authors.lastname: Billman
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D016757:Death, Sudden, Cardiac; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D010276:Parasympatholytics / Q000494:pharmacology; D005082:Physical Exertion / Q000502:physiology*; D011237:Predictive Value of Tests; D012307:Risk Factors; D014693:Ventricular Fibrillation / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*
chemical_list: D010276:Parasympatholytics; D001285:Atropine