title: Expedient total syntheses of rhein and diacerhein via Fries rearrangement.
abstract: Short and practical total syntheses of rhein (1) and diacerhein (2) have been achieved via a Fries rearrangement and bis-carbonylation strategy followed by cyclization in molten salt, starting from dibromoester 7.
authors.affiliation: Université Louis Pasteur, Faculté de Pharmacie, UMR 7514, Laboratoire de Synthèse Bio-Organique, 74 route du Rhin, 67401 Illkirch-Graffenstaden, France.
authors.forename: Steve
authors.initials: S
authors.lastname: Tisserand
authors.forename: Rachid
authors.initials: R
authors.lastname: Baati
authors.forename: Marc
authors.initials: M
authors.lastname: Nicolas
authors.forename: Charles
authors.initials: C
authors.lastname: Mioskowski
mesh_terms: D000880:Anthraquinones / Q000138:chemical synthesis*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D000880:Anthraquinones; D000894:Anti-Inflammatory Agents, Non-Steroidal; C025292:diacerein; C020491:rhein