title: [Influence of smoking on the cerebral hemodynamics and biochemical blood indices in chronic insufficiency of brain circulation].
abstract: The influence of smoking on cerebral hemodynamics and biochemical blood indices has been studied in 50 male patients with chronic insufficiency of brain circulation (CIBC), aged 40-50 years, divided into 2 groups: smoking (n=26) and nonsmoking (n=24). Smoking was shown to play a substantial role in the development of discirculatory encephalopathy with atrophic brain changes, causing metabolic disturbances (a shift of acid-basic balance towards acidosis) and microcirculation disorders due to altered cerebrovascular reactivity. These alterations develop previously to hemodynamically significant atherosclerotic arteries lesion and emerge irrespective of the presence of atherosclerotic vascular changes, atherogenic shifts of lipid metabolism, disturbances of free-radical processes and platelet aggregation.
authors.forename: O V
authors.initials: OV
authors.lastname: Tikhomirova
authors.forename: A A
authors.initials: AA
authors.lastname: Skoromets
authors.forename: N N
authors.initials: NN
authors.lastname: Zybina
authors.forename: A V
authors.initials: AV
authors.lastname: Borisov
authors.forename: A S
authors.initials: AS
authors.lastname: Iova
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Lebedev
authors.forename: A M
authors.initials: AM
authors.lastname: Martirosian
authors.forename: E L
authors.initials: EL
authors.lastname: Pugacheva
authors.forename: A P
authors.initials: AP
authors.lastname: Skoromets
authors.forename: T A
authors.initials: TA
authors.lastname: Skoromets
authors.forename: K V
authors.initials: KV
authors.lastname: Shekotov
mesh_terms: D001921:Brain / Q000098:blood supply* / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000502:physiology*; D008074:Lipoproteins / Q000378:metabolism*; D012907:Smoking / Q000009:adverse effects*
chemical_list: D008074:Lipoproteins