title: [Efficacy of lidocaine on seizures by intravenous and intravenous-drip infusion].
abstract: We retrospectively studied the efficacy of intravenous and intravenous-drip infusion administration of lidocaine on seizures treated in Saitama Children's Medical Center during the period of 1997-2002. Thirty eight seizures of 29 children (12 boys and 17 girls, average age 41.4 months) were treated with lidocaine. The overall rate of effectiveness was 53%. The response to lidocaine appeared within 5 minutes in all episodes. Good response to lidocaine was noted, in 36% of patients with epilepsy, in 72% with CNS infection and in 80% with benign infantile convulsions; in 42% with generalized seizures and in 63% with partial seizures. Thus there was no significant difference in efficacy among the underlying disorders and seizure types. The adverse reaction of SpO2 decrease was found in one patient. We conclude that lidocaine can be used as a second-line, anti-convulsive drug in status epilepticus based on its prompt effectiveness and low risk of side effects.
authors.affiliation: Division of Neurology, Saitama Children's Medical Center, Iwatsuki, Saitama. nobuyosi@is.icc.u-tokai.ac.jp
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Sugiyama
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Hamano
authors.forename: Mika
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Manabu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Eto
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D012189:Retrospective Studies; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D008012:Lidocaine