[Expression and significance of alpha5beta1 integrin in abnormal scars].
OBJECTIVE
To study the expression of alpha5beta1 integrin in the abnormal scars and its role and significance in the formation and development of abnormal scars.


METHODS
The expression of alpha5beta1 integrin was observed in hypertrophic scar (15 samples), keloid (15 samples) and normal skin (10 samples) with SP immunohistochemical method and colloidal gold immuno-electron microscopic technique. The data were semi-quantitatively analyzed.


RESULTS
The expression levels of alpha5beta1 integrin in the fibroblasts of keloids and hypertrophic scars were higher than normal skin; the expression of alpha5beta1 integrin in the fibroblasts of keloids was higher than hypertrophic scars (P < 0.01).


CONCLUSIONS
The alpha5beta1 integrin appears to have close relation to the formation and development of abnormal scars. To find a way to decrease the expression level of alpha5beta1 integrin in fibroblasts may be a new approach to inhibit scar hypertrophy.
Yu
You
Y
Department of Plastic Surgery, Emergency Medical Center of Chongqing, Chongqing 400014, China.
He
Guang-Zhao
GZ
Wu
Yi
Y
Huang
Chong-Ben
CB
D002921:Cicatrix / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D039081:Integrin alpha5beta1 / Q000032:analysis* / Q000378:metabolism; D007627:Keloid / Q000378:metabolism / Q000473:pathology*; D016253:Microscopy, Immunoelectron; D012867:Skin / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure
D039081:Integrin alpha5beta1