title: A cytogenetic follow-up of some highly irradiated victims of the Chernobyl accident.
abstract: A follow-up of 10 highly irradiated men, mostly reactor crew, from the Chernobyl accident is described. Their pre-accident medical conditions and relevant medical status approximately 10-13 y later are listed. A comparison is made between estimates of their average whole-body penetrating radiation doses derived from several biological parameters. First estimates were based on their presenting severity of prodromal sickness, early changes in blood cell counts and dicentric chromosome aberrations in lymphocytes. In three cases ESR measurements on tooth enamel were also made. Retrospective dosimetry using FISH translocations was attempted 10-13 y later. This showed good agreement for those patients with the lower earlier dose estimates, up to about 3 Gy. For the others, extending up to about 12 Gy, the translocations indicated lower values, suggesting that in these cases translocations had somewhat declined. Repeated chromosomal examinations during the follow-up period showed an expected decline in dicentric frequencies. The pattern of decline was bi-phasic with a more rapid first phase, with a half-life of approximately 4 months followed by a slower decline with half-lives around 2-4 y. The rapid phase persisted for a longer time in those patients who had received the highest doses. 10-13 y later dicentric levels were still above normal background, but well below the translocation frequencies.
authors.affiliation: Medical Radiological Research Centre of RAMS, Koroliov St. 4, Obninsk, Kaluga Region, 249036, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Sevan'kaev
authors.forename: D C
authors.initials: DC
authors.lastname: Lloyd
authors.forename: A A
authors.initials: AA
authors.lastname: Edwards
authors.forename: I K
authors.initials: IK
authors.lastname: Khvostunov
authors.forename: G F
authors.initials: GF
authors.lastname: Mikhailova
authors.forename: E V
authors.initials: EV
authors.lastname: Golub
authors.forename: N N
authors.initials: NN
authors.lastname: Shepel
authors.forename: N M
authors.initials: NM
authors.lastname: Nadejina
authors.forename: I A
authors.initials: IA
authors.lastname: Galstian
authors.forename: V Yu
authors.initials: VY
authors.lastname: Nugis
authors.forename: L
authors.initials: L
authors.lastname: Barrios
authors.forename: M R
authors.initials: MR
authors.lastname: Caballin
authors.forename: J F
authors.initials: JF
authors.lastname: Barquinero
mesh_terms: D000328:Adult; D000465:Algorithms; D001822:Body Burden; D047852:Chernobyl Nuclear Accident; D002869:Chromosome Aberrations / Q000528:radiation effects*; D002877:Chromosomes, Human / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis*; D011210:Power Plants; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods*; D011835:Radiation Protection / Q000379:methods*; D018788:Radioactive Hazard Release; D012062:Relative Biological Effectiveness; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D014455:Ukraine; D014915:Whole-Body Counting / Q000379:methods