title: [Epidemiological survey of HBsAg carriers in the Uighur and Han populations in the Khotan Area of Xinjiang autonomous region].
abstract: OBJECTIVE
  To survey nonsymptomatic HBsAg carriers in the Uighur and Han populations in Khotan Area of Xinjiang Autonomous region.
  
  
  METHODS
  HBsAg was detected using colloidal gold-labeled double antibody sandwich method.
  
  
  RESULTS
  These investigations included 2 597 subjects consisting of 2 022 Uighur and 575 Han subjects. The total HBsAg carrier rate in the Uighur population was 1.48% (30/2 022), specifically 1.078% in male and 1.59% in female subjects. No significant differences were observed in the age between male and female HBsAg carriers, who had an average age of 35 years. In the Han population, the total HBsAg carrier rate was 6.09% (30/575), and was 5.6% in male and 4.4% in female subjects. The average age of the male carriers was 36.3 years and 27.6 years in the female carriers, which showed significant difference in respect to HBsAg carrier rate. The HBsAg carrier rate showed significant difference between Uighur and Han populations in Khotan Area (P<0.01).
  
  
  CONCLUSIONS
  The HBsAg carrier rate in Uighur population in Khotan Area is consistent with that in areas with low HBV infection, whereas the Han population exhibit features similar to those in areas with moderately HBV prevalence in the inland regions. The low HBsAg carrier rate in Uighurs might be attributed to the their customs in diet, eating habit, local living environment and the difference in HLA gene distribution. The authors suppose that such antigens as HLA-Bw41 might be protective against HBV infection.
authors.affiliation: People's Hospital of Hetian County, Hetian 848100, China. kurax-ht@21cn.com
authors.forename: Tuohuti
authors.initials: T
authors.lastname: Kurexijiang
authors.forename: Wufuer
authors.initials: W
authors.lastname: Hamulati
authors.forename: Li-zhan
authors.initials: LZ
authors.lastname: Zhang
authors.forename: Rouzi
authors.initials: R
authors.lastname: Habaer
authors.forename: Yimiti
authors.initials: Y
authors.lastname: Halike
authors.forename: Qin
authors.initials: Q
authors.lastname: Cheng
authors.forename: Yu-li
authors.initials: YL
authors.lastname: Dong
authors.forename: Yushan
authors.initials: Y
authors.lastname: Gulina
authors.forename: Aisha
authors.initials: A
authors.lastname: Maimaitiabula
authors.forename: Zhong-xing
authors.initials: ZX
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002353:Carrier State / Q000453:epidemiology*; D002681:China / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D015235:HLA-B Antigens / Q000097:blood*; D006509:Hepatitis B / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016036:Seroepidemiologic Studies
chemical_list: D015235:HLA-B Antigens; C056322:HLA-B41 antigen; D006514:Hepatitis B Surface Antigens