title: Simple surface modification of poly(epsilon-caprolactone) for apatite deposition from simulated body fluid.
abstract: Poly(epsilon-caprolactone) (PCL) with a bone-like apatite layer bound to its surface could be useful as a scaffold for tissue engineering applications. In the present study, the surface of PCL was treated with aqueous NaOH to introduce carboxylate groups onto the surface. The NaOH-treated material was subsequently dipped in aqueous CaCl(2) and K(2)HPO(4).3H(2)O alternately three times to deposit apatite nuclei on the surface. The surface-modified material successfully formed a dense and uniform bone-like surface apatite layer after incubation for 24 h in simulated body fluid with ion concentrations approximately equal to those of human blood plasma.
authors.affiliation: Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, 2-41-6, Aomi, Koto-ku, Tokyo135-0064, Japan. a-oyane@aist.go.jp
authors.forename: Ayako
authors.initials: A
authors.lastname: Oyane
authors.forename: Masaki
authors.initials: M
authors.lastname: Uchida
authors.forename: Cleo
authors.initials: C
authors.lastname: Choong
authors.forename: James
authors.initials: J
authors.lastname: Triffitt
authors.forename: John
authors.initials: J
authors.lastname: Jones
authors.forename: Atsuo
authors.initials: A
authors.lastname: Ito
mesh_terms: D020341:Absorbable Implants; D001031:Apatites / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001031:Apatites; D018786:Bone Substitutes; D011091:Polyesters; C016240:polycaprolactone