title: Enzyme-based amperometric biosensors for continuous and on-line monitoring of cerebral extracellular microdialysate.
abstract: Analytical systems integrating in vivo microdialysis sampling with enzyme-based electrochemical biosensor detection have been increasingly accepted to be a new technique for continuous and on-line monitoring of biologically important species. Extensive interests in such integrated on-line analytical systems have suggested that these systems are very useful for physiological and pathological investigations. This review mainly focuses on the principle, development and striking applications of the enzyme-based amperometric biosensors integrated with in vivo microdialysis for continuous and on-line monitoring of cerebral extracellular fluid in recent years.
authors.affiliation: Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
authors.forename: Meining
authors.initials: M
authors.lastname: Zhang
authors.forename: Lanqun
authors.initials: L
authors.lastname: Mao
mesh_terms: D000109:Acetylcholine / Q000737:chemistry; D000818:Animals; D001331:Automation; D015374:Biosensing Techniques; D001921:Brain / Q000378:metabolism; D004563:Electrochemistry / Q000379:methods*; D005947:Glucose / Q000737:chemistry; D018698:Glutamic Acid / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D019271:Hypoxanthine / Q000737:chemistry; D007124:Immunoenzyme Techniques / Q000379:methods; D019344:Lactic Acid / Q000737:chemistry; D005680:gamma-Aminobutyric Acid / Q000737:chemistry
chemical_list: D019271:Hypoxanthine; D019344:Lactic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D006861:Hydrogen Peroxide; D005947:Glucose; D000109:Acetylcholine