Challenging conventional wisdom: the etiologic role of dopamine oxidative stress in Parkinson's disease.
Oxidative stress is well documented in Parkinson's disease (PD) and has been attributed to dopamine oxidative metabolism. However, evidence of oxidative stress is found in a variety of neurodegenerative disorders, suggesting that more general factors are responsible or that cytodestructive processes secondarily generate oxyradical products. Increasing evidence points away from dopamine metabolism as an important contributor to PD neurodegeneration. Predictions from the dopamine oxidative stress hypothesis of PD reveal multiple inconsistencies. Although the clinical and therapeutic importance of the nigrostriatal dopaminergic system is undeniable, PD neuropathology is much more widespread.
Ahlskog
J Eric
JE
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. eahlskog@mayo.edu
D001933:Brain Stem / Q000378:metabolism; D003704:Dementia / Q000150:complications; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D016631:Lewy Bodies / Q000378:metabolism; D009410:Nerve Degeneration / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D000857:Olfaction Disorders / Q000150:complications; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000150:complications / Q000209:etiology / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D020187:REM Sleep Behavior Disorder / Q000150:complications; D051843:Synucleins; D025801:Ubiquitin / Q000378:metabolism
D009419:Nerve Tissue Proteins; D051843:Synucleins; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex; D004298:Dopamine