title: [Acute renal failure and 2,8-dihydroxyadeninuria].
abstract: We report the case of a 65 year old man, with a history of recurrent urolithiasis, who was referred for an acute renal failure. Investigations deny obstructive or glomerular involvement. 2,8-Dihydroxyadeninuria was diagnosed with the help of crystalluria. This rare metabolic disease is due to a deficiency of adenine phosphoribosyltransferase, a purine salvage enzyme. Allopurinol, a low purine diet and high fluid intake made possible the nearly entire regression of renal failure.
authors.affiliation: Service de néphrologie et de dialyse, Centre hospitalier de Roubaix. maxime.hoffmann@free.fr
authors.forename: M
authors.initials: M
authors.lastname: Hoffmann
authors.forename: A
authors.initials: A
authors.lastname: Talaszka
authors.forename: J P
authors.initials: JP
authors.lastname: Bocquet
authors.forename: H
authors.initials: H
authors.lastname: Le Monies de Sagazan
authors.forename: M
authors.initials: M
authors.lastname: Daudon
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D000225:Adenine / Q000031:analogs & derivatives* / Q000652:urine*; D000228:Adenine Phosphoribosyltransferase / Q000172:deficiency*; D000368:Aged; D006801:Humans; D008297:Male; D012008:Recurrence; D014545:Urinary Calculi / Q000209:etiology
chemical_list: C002993:2,8-dihydroxyadenine; D000228:Adenine Phosphoribosyltransferase; D000225:Adenine