Hepatic arterial infusion of paclitaxel for liver metastasis from gastric cancer.
Little is known about hepatic arterial infusion (HAI) of paclitaxel for hepatic malignancies. The authors administered paclitaxel via the HAI port in two patients with liver metastases from gastric cancer. Both patients were uneventfully treated without any serious complications, and its anti-tumor effect on 5-fluouracil resistant liver metastases was confirmed. However, the kinetics of venous paclitaxel concentration following HAI was similar to that after intravenous injection. Our findings did not support the advantage of paclitaxel HAI therapy, although HAI of this agent was well tolerated.
Tono
Takeshi
T
Department of Surgery, NTT West Osaka Hospital, Osaka, Japan. t.tono@zero.ad.jp
Iwazawa
Takashi
T
Matsui
Shigeo
S
Yano
Hiroshi
H
Kimura
Yutaka
Y
Kanoh
Toshiyuki
T
Ohnishi
Tadashi
T
Nakano
Yoshiaki
Y
Okamura
Jun
J
Monden
Takushi
T
D000328:Adult; D000368:Aged; D004341:Drug Evaluation; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000556:secondary*; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed
D017239:Paclitaxel