The link between PKCalpha regulation and cellular transformation.
Protein kinase Calpha (PKCalpha) is a serine/threonine protein kinase that has been implicated in the regulation of a variety of cellular functions such as proliferation, differentiation and apoptosis in response to a diverse range of stimuli. In order to execute these biological events PKCalpha activity is modulated by, and functionally interacts with, a number of proto-oncogenes, therefore it is perhaps unsurprising that dysregulation of PKCalpha is associated with a diverse range of cancers. Recently, PKCalpha has become a target for a number of anti-cancer therapies. The purpose of this review is to describe how PKCalpha regulates key biological events, to gain an insight into how PKCalpha-mediated cellular transformation may occur. In this way, it may be possible to design therapeutic tools to combat cancers specifically associated with PKCalpha dysfunction.
Michie
Alison M
AM
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, Scotland, UK. a.michie@udcf.gla.ac.uk
Nakagawa
Rinako
R
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D011493:Protein Kinase C / Q000378:metabolism*; D051571:Protein Kinase C-alpha
D000970:Antineoplastic Agents; C496628:PRKCA protein, human; D011493:Protein Kinase C; D051571:Protein Kinase C-alpha