title: Materials for phantoms for terahertz pulsed imaging.
abstract: Phantoms are commonly used in medical imaging for quality assurance, calibration, research and teaching. They may include test patterns or simulations of organs, but in either case a tissue substitute medium is an important component of the phantom. The aim of this work was to identify materials suitable for use as tissue substitutes for the relatively new medical imaging modality terahertz pulsed imaging. Samples of different concentrations of the candidate materials TX151 and napthol green dye were prepared, and measurements made of the frequency-dependent absorption coefficient (0.5 to 1.5 THz) and refractive index (0.5 to 1.0 THz). These results were compared qualitatively with measurements made in a similar way on samples of excised human tissue (skin, adipose tissue and striated muscle). Both materials would be suitable for phantoms where the dominant mechanism to be simulated is absorption (approximately 100 cm(-1) at 1 THz) and where simulation of the strength of reflections from boundaries is not important; for example, test patterns for spatial resolution measurements. Only TX151 had a frequency-dependent refractive index close to that of tissue, and could therefore be used to simulate the layered structure of skin, the complexity of microvasculature or to investigate frequency-dependent interference effects that have been noted in terahertz images.
authors.affiliation: University of Leeds, Wellcome Wing, Leeds General Infirmary, Leeds, LS1 3EX, UK.
authors.forename: Gillian C
authors.initials: GC
authors.lastname: Walker
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Berry
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Smye
authors.forename: David S
authors.initials: DS
authors.lastname: Brettle
mesh_terms: D004396:Coloring Agents / Q000528:radiation effects*; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods*; D005782:Gels / Q000528:radiation effects*; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods*; D008422:Materials Testing / Q000379:methods*; D008872:Microwaves; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted
chemical_list: D004396:Coloring Agents; D005782:Gels