A fibrinogen-binding protein of Staphylococcus lugdunensis.
A gene called fbl, encoding a Staphylococcus lugdunensis fibrinogen-binding protein, was identified by phage display. The encoded protein, Fbl, is a member of the Sdr-family, a group of staphylococcal cell surface proteins containing a characteristic serine-aspartate repeat region. The fibrinogen-binding domain was mapped to 313 amino acids, and shows 62% identity to the corresponding region in clumping factor (ClfA) from Staphylococcus aureus. Anti-serum against ClfA cross-reacted with Fbl, and blocked S. lugdunensis adherence to fibrinogen. Twelve clinical isolates of S. lugdunensis analysed by Southern blot all had an fbl-like gene.
Nilsson
Martin
M
Department of Microbiology, Swedish University of Agricultural Sciences, SLU, P.O. Box 7025, SE-750 07 Uppsala, Sweden.
Bjerketorp
Joakim
J
Guss
Bengt
B
Frykberg
Lars
L
D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism*; D008969:Molecular Sequence Data; D013210:Staphylococcus / Q000737:chemistry*
D002352:Carrier Proteins; D005340:Fibrinogen