title: A new ene-triyne antibiotic from the fungus Baeospora myosura.
abstract: The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active against Gram-negative bacteria and a yeast. MICs against several strains of Staphylococcus aureus were as low as 0.001 microg/mL. Analogues of 1 that did not contain the ene-triyne moiety were inactive against all microorganisms tested. The isolation of this new natural product was complicated by the highly reactive nature of the conjugated terminal polyacetylene.
authors.affiliation: Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065-0900, USA. craig_parish@merck.com
authors.forename: Craig A
authors.initials: CA
authors.lastname: Parish
authors.forename: Joann
authors.initials: J
authors.lastname: Huber
authors.forename: Jenny
authors.initials: J
authors.lastname: Baxter
authors.forename: Antonio
authors.initials: A
authors.lastname: González
authors.forename: Javier
authors.initials: J
authors.lastname: Collado
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Platas
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Diez
authors.forename: Francisca
authors.initials: F
authors.lastname: Vicente
authors.forename: Karen
authors.initials: K
authors.lastname: Dorso
authors.forename: George
authors.initials: G
authors.lastname: Abruzzo
authors.forename: Kenneth
authors.initials: K
authors.lastname: Wilson
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053279:Polyynes; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011108:Polymers; D053279:Polyynes; D000114:Acetylene