Functional divergency oriented synthesis of azoninones as the key intermediates for bioactive indolizidine alkaloids analogs.
A functional divergency oriented synthetic approach to the azoninone (9-membered lactams), key intermediate for the indolizidine alkaloids library, using amide enolate induced aza-Claisen rearrangement has been achieved.
Jung
Jae-Kyung
JK
College of Pharmacy, Seoul National University, Seoul 151-742, Korea. orgjkjung@chungbuk.ac.kr [corrected]
Choi
Nam-Song
NS
Suh
Young-Ger
YG
D000470:Alkaloids / Q000138:chemical synthesis*; D001391:Azo Compounds / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D007212:Indolizines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D012997:Solvents; D021241:Spectrometry, Mass, Electrospray Ionization
D000470:Alkaloids; D001391:Azo Compounds; D007202:Indicators and Reagents; D007212:Indolizines; D012997:Solvents