Persistent neural activity: prevalence and mechanisms.
Persistent neural activity refers to a sustained change in action potential discharge that long outlasts a stimulus. It is found in a diverse set of brain regions and organisms and several in vitro systems, suggesting that it can be considered a universal form of circuit dynamics that can be used as a mechanism for short-term storage and accumulation of sensory or motor information. Both single cell and network mechanisms are likely to co-operate in generating persistent activity in many brain areas.
Major
Guy
G
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA. gmajor@princeton.edu
Tank
David
D
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D005246:Feedback / Q000502:physiology; D006801:Humans; D023421:Models, Animal; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology