title: Feasibility study of ultrasonic fatty liver biopsy: texture vs. attenuation and backscatter.
abstract: The objective of this study was to compare textural to attenuation/backscatter indices of fatty liver correlated to histology to suggest the better approach for an objective noninvasive ultrasonic "biopsy". Forty-four patients with severe steatosis by histopathology were selected for this study. Ten patients had "pure" fatty liver and 34 had in addition fibrosis and/or inflammation. Ultrasonic images were acquired before needle insertion. The ROI used for biopsy was marked on the ultrasonic image and characterized by three attenuation/backscatter and 18 textural related indices. Statistical analysis was performed using logistic regression. Twenty-one healthy subjects served as control. The attenuation/backscatter indices were superior to textural indices in differentiating between the categories studied. Pure fatty livers could be reliably identified (AUC = 1, SE = 0). Among the 18 textural indices, "co-occurrences sum entropy" and "co-occurrences entropy" presented the best results. Attenuation/backscatter based indices appear to have better potential than the textural based indices.
authors.affiliation: Department of Medical Imaging, Rambam Medical Center and Faculty of Medicine, Haifa, Israel. D_Gaitini@Rambam.Health.Gov.IL
authors.forename: Diana
authors.initials: D
authors.lastname: Gaitini
authors.forename: Yaacov
authors.initials: Y
authors.lastname: Baruch
authors.forename: Eduard
authors.initials: E
authors.lastname: Ghersin
authors.forename: Ella
authors.initials: E
authors.lastname: Veitsman
authors.forename: Hedvika
authors.initials: H
authors.lastname: Kerner
authors.forename: Bruria
authors.initials: B
authors.lastname: Shalem
authors.forename: Geva
authors.initials: G
authors.lastname: Yaniv
authors.forename: Chen
authors.initials: C
authors.lastname: Sarfaty
authors.forename: Haim
authors.initials: H
authors.lastname: Azhari
mesh_terms: D019540:Area Under Curve; D001707:Biopsy, Needle / Q000379:methods; D005234:Fatty Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D006505:Hepatitis / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014465:Ultrasonics; D018084:Ultrasonography, Interventional