Cytotoxic neolignans: an SAR study.
The neolignans, magnolol 1 and honokiol 2 have been reported to inhibit the growth of several tumor cell lines in vitro and in vivo. The chemical structure of magnolol and honokiol consists of biphenyl skeleton with phenolic and allylic functionalities. Analogs of 1 and 2 containing different substitution have been studies for their effect on the growth of Hep-G2 and their structure-activity relationships were reported in this work.
Kong
Zwe-Ling
ZL
Food Science Department, National Taiwan Ocean University, Keelung, Taiwan, ROC.
Tzeng
Shin-Cheng
SC
Liu
Yeuk-Chuen
YC
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D000498:Allyl Compounds; D010636:Phenols
D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols