RNA-binding proteins and neural development: a matter of targets and complexes.
RNA-binding proteins control multiple steps of nuclear and cytoplasmic RNA processing including alternative splicing, stabilization, transport and translational repression of RNAs. Here we present existing evidence showing that RNA-binding proteins expressed in the nervous system are required in many steps of its development and play multiple roles during the life of a neuron. We describe emerging views based on recent studies strongly suggesting that RNA-binding proteins cooperate actively within neurons in large multifunctional complexes to regulate the flow of information encoded in ribonomes in a coordinated fashion.
Agnès
François
F
Embryologie Moléculaire et Expérimentale, UMR 8080 CNRS-Université Paris-Sud, Bât 445, 91405 Orsay Cedex, France. francois.agnes@ibaic.u-psud.fr
Perron
Muriel
M
D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000254:growth & development* / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000502:physiology*; D016601:RNA-Binding Proteins / Q000502:physiology*
D016601:RNA-Binding Proteins