title: New norditerpenoids with trypanocidal activity from Vitex trifolia.
abstract: Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11 microM (1), 36 microM (2), 34 microM (3), 34 microM (4), 66 microM (5), 66 microM (6), and >265 microM (7).
authors.affiliation: Tsukuba Medicinal Plant Research Station, National Institute of Health Sciences, Hachiman-dai, Tsukuba, Japan.
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Kiuchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsuo
authors.forename: Michiho
authors.initials: M
authors.lastname: Ito
authors.forename: Tran Kim
authors.initials: TK
authors.lastname: Qui
authors.forename: Gisho
authors.initials: G
authors.lastname: Honda
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D005638:Fruit / Q000737:chemistry; D010084:Oxidation-Reduction; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014344:Trypanocidal Agents / Q000302:isolation & purification* / Q000494:pharmacology* / Q000633:toxicity; D014349:Trypanosoma cruzi / Q000187:drug effects; D020950:Vitex / Q000737:chemistry*
chemical_list: D004224:Diterpenes; D014344:Trypanocidal Agents