title: Anti-coxsackievirus B3 activity of 2-amino-3-nitropyrazolo[1,5-a]pyrimidines and their analogs.
abstract: A novel class of 2-amino-4-nitropyrazolo[1,5-a]pyrimidines has been identified as potent inhibitors of coxsackievirus B3 replication. The synthesis of these compounds is based on the regioselective reaction of 3,5-diamino-5-nitropyrazole with unsymmetrical beta-diketones at catalysis by hydrochloric acid leading to 2-amino-4-nitropyrazolo[1,5-a]pyrimidines as key steps.
authors.affiliation: Department of Medicinal Chemistry, Research Center for Antibiotics, 3a Nagatinskaya str., Moscow 117105, Russia.
authors.forename: Vadim A
authors.initials: VA
authors.lastname: Makarov
authors.forename: Olga B
authors.initials: OB
authors.lastname: Riabova
authors.forename: Vladimir G
authors.initials: VG
authors.lastname: Granik
authors.forename: Hans-Martin
authors.initials: HM
authors.lastname: Dahse
authors.forename: Axel
authors.initials: A
authors.lastname: Stelzner
authors.forename: Peter
authors.initials: P
authors.lastname: Wutzler
authors.forename: Michaela
authors.initials: M
authors.lastname: Schmidtke
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D002460:Cell Line; D029822:Enterovirus B, Human / Q000187:drug effects*; D006801:Humans; D051379:Mice; D011720:Pyrazoles / Q000737:chemistry*; D011743:Pyrimidines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D011720:Pyrazoles; D011743:Pyrimidines