Preparation of cyclic peptide libraries using intramolecular oxime formation.
A new method for the synthesis of cyclic head-to-side chain peptide libraries has been developed in which the key cyclization step involves reaction between a C-terminal ketone and an N-terminal hydroxylamine to form a macrocyclic oxime. This methodology efficiently delivers cyclic products that consist of mixtures of syn and anti isomers.
Roberts
Kade D
KD
School of Chemistry, The University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia. kade.roberts@ludwig.edu.au
Lambert
John N
JN
Ede
Nicholas J
NJ
Bray
Andrew M
AM
D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D010091:Oximes / Q000737:chemistry; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000138:chemical synthesis*
D010091:Oximes; D019151:Peptide Library; D010456:Peptides, Cyclic