title: Topical PDGF-BB results in limited healing in a patient with Werner's syndrome and chronic leg ulcers.
abstract: Impaired wound healing is a feature of Werner's syndrome. Treatment of one such patient with painful chronic leg ulcers included topical application of PDGF-BB. Granulation increased slightly, enabling full-thickness skin grafting to take place.
authors.affiliation: Department of Dermatology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany. wollina-uw@khdf.de
authors.forename: U
authors.initials: U
authors.lastname: Wollina
authors.forename: M
authors.initials: M
authors.lastname: Gruner
authors.forename: A
authors.initials: A
authors.lastname: Koch
authors.forename: E
authors.initials: E
authors.lastname: Köstler
authors.forename: W
authors.initials: W
authors.lastname: Hubl
authors.forename: N B
authors.initials: NB
authors.lastname: Hanson
authors.forename: J
authors.initials: J
authors.lastname: Oshima
mesh_terms: D000279:Administration, Cutaneous; D000077214:Becaplermin; D003094:Collagen / Q000235:genetics; D017364:Collagenases / Q000235:genetics; D006801:Humans; D007871:Leg Ulcer / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology / Q000627:therapeutic use*; D020574:Proto-Oncogene Proteins c-sis; D017592:Skin Care / Q000379:methods; D016896:Treatment Outcome; D014898:Werner Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D014945:Wound Healing / Q000187:drug effects
chemical_list: D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin; D003094:Collagen; D017364:Collagenases