[The mast cells phagocytose bacteria].
In the last years there has been a growing number of reports concerning the role of mast cells in host defense against bacteria. The mast cell membrane is replete with many receptors/molecules, including those that promote the recognition and binding of bacteria. Mast cells exhibit two basic mechanisms of microbial recognition: opsonin-dependent (via Fc and C3 receptors) and opsonin-independent (via integrins, CD48 molecule and Toll-like receptors). Moreover, mast cells phagocytose and kill adherent bacteria. Phagocytosis of bacteria results in the presentation of bacterial antigens for MHC class I to T cells.
Rdzany
Rafał S
RS
Zakład Immunologii Doświadczalnej, Uniwersytet Medyczny w Łodzi. rsrdzany@csk.am.lodz.pl
Brzezińska-Błaszczyk
Ewa
E
D000818:Animals; D017951:Antigen Presentation; D001419:Bacteria / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D018836:Inflammation Mediators / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology*; D011971:Receptors, Immunologic / Q000378:metabolism
D018836:Inflammation Mediators; D011971:Receptors, Immunologic; C091196:opsonin receptor