title: Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase.
abstract: Digalactosyl and monogalactocyl diacylglycerols (DGDG and MGDG), which were identified as anti-hyperlipemia active components in Colocasia esculenta (Taro), were synthesized. The inhibitory activity of DGDG, MGDG and related compounds on human lanosterol synthase was evaluated as anti-hyperlipemic activity. DGDG with two myristoyl groups at both sn-1 and sn-2 positions and with an oleoyl group at the sn-1 position showed the most potent activity.
authors.affiliation: National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-Ku, Tokyo 158-8501, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Tanaka
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sakano
authors.forename: Akito
authors.initials: A
authors.lastname: Nagatsu
authors.forename: Masaaki
authors.initials: M
authors.lastname: Shibuya
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ebizuka
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Goda
mesh_terms: D002240:Carbohydrate Sequence; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D038983:Galactolipids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D019751:Intramolecular Transferases / Q000037:antagonists & inhibitors*; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D038983:Galactolipids; C007388:digalactosyldiacylglycerol; D019751:Intramolecular Transferases; C021924:lanosterol synthase