title: Measurements of T1 and T2 relaxation times of colon cancer metastases in rat liver at 7 T.
abstract: The purpose of this study was to investigate the magnetic resonance imaging (MRI) characteristics of colon cancer metastases in rat liver at 7 T. A dedicated RF microstrip coil of novel design was built in order to increase the signal-to-noise ratio and, in combination with respiratory triggering, to minimize motion artifacts. T1- and T2-weighted MR imaging was performed to follow tumor growth. T1-weighted images provided a good anatomical delineation of the liver structure, while the best contrast between metastases and normal liver tissue was achieved with T2-weighted images. Measurements of T1 and T2 relaxation times were performed with inversion recovery FLASH and Carr-Purcell-Meiboom-Gill and inversion recovery FLASH imaging sequences, respectively, for quantitative MR characterization of metastases. Both the T1 and T2 of the metastases were significantly higher than those of normal liver tissue. Further, an increase in the T1 relaxation time of the metastases was observed with tumor growth. These findings suggest that quantitative in vivo MR characterization provides information on tumor development and possibly response to therapy, though additional studies are needed to elucidate the correlation between the changes in relaxation times and tumor microenvironment.
authors.affiliation: Department of Radiology, University Medical Center Nijmegen, Nijmegen, The Netherlands. G.Gambarota@rad.umcn.nl
authors.forename: G
authors.initials: G
authors.lastname: Gambarota
authors.forename: A
authors.initials: A
authors.lastname: Veltien
authors.forename: H
authors.initials: H
authors.lastname: van Laarhoven
authors.forename: M
authors.initials: M
authors.lastname: Philippens
authors.forename: A
authors.initials: A
authors.lastname: Jonker
authors.forename: O R
authors.initials: OR
authors.lastname: Mook
authors.forename: W M
authors.initials: WM
authors.lastname: Frederiks
authors.forename: A
authors.initials: A
authors.lastname: Heerschap
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000473:pathology* / Q000556:secondary*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000473:pathology*; D004195:Disease Models, Animal; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008113:Liver Neoplasms / Q000473:pathology* / Q000556:secondary*; D008297:Male; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity