title: Evidence of QTLs on chromosomes 1q42 and 8q24 for LDL-cholesterol and apoB levels in the HERITAGE family study.
abstract: Genome-wide multipoint linkage analyses were performed to identify chromosomal regions harboring genes influencing LDL-cholesterol, total apolipoprotein B (apoB), and LDL-apoB levels using 654 markers. They were assessed in a sedentary state (baseline) and after a 20 week endurance training program. Strong evidence for two quantitative trait loci (QTLs) for baseline levels was found. There is linkage evidence in black families on chromosomes 1q41-q44 [at marker D1S2860, 238 centimorgan (cM), with a maximum log of the odds (LOD) score of 3.7 for LDL-apoB] and in white families on chromosome 8q24 (at marker D8S1774, 142 cM, with LOD scores of 3.6, 3.3, and 2.5 for baseline LDL-cholesterol, LDL-apoB, and apoB, respectively). There were no strong signals for the lipoprotein training responses (as computed as the difference in posttraining minus baseline levels). In conclusion, QTLs for baseline apoB and LDL-cholesterol levels on chromosomes 1q41-q44 (in blacks) and 8q24 (in whites) were found. As there are no known strong candidate genes in these regions for lipids, follow-up studies to determine the source of those signals are needed.
authors.affiliation: Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, USA. maryf@wubios.wustl.edu
authors.forename: Mary F
authors.initials: MF
authors.lastname: Feitosa
authors.forename: Ingrid B
authors.initials: IB
authors.lastname: Borecki
authors.forename: Tuomo
authors.initials: T
authors.lastname: Rankinen
authors.forename: Treva
authors.initials: T
authors.lastname: Rice
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Després
authors.forename: Yvon C
authors.initials: YC
authors.lastname: Chagnon
authors.forename: Jacques
authors.initials: J
authors.lastname: Gagnon
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Leon
authors.forename: James S
authors.initials: JS
authors.lastname: Skinner
authors.forename: Claude
authors.initials: C
authors.lastname: Bouchard
authors.forename: Michael A
authors.initials: MA
authors.lastname: Province
authors.forename: D C
authors.initials: DC
authors.lastname: Rao
mesh_terms: D001055:Apolipoproteins B / Q000097:blood* / Q000378:metabolism; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood* / Q000378:metabolism; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002898:Chromosomes, Human, Pair 8; D004492:Edetic Acid / Q000737:chemistry; D015444:Exercise; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D016678:Genome; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D010641:Phenotype; D040641:Quantitative Trait Loci; D013997:Time Factors
chemical_list: D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D005819:Genetic Markers; D007328:Insulin; D008074:Lipoproteins; D004492:Edetic Acid