Acrylic polymeric nanospheres for the release and recognition of molecules of clinical interest.
Cross-linked poly(methylmethacrylate-co-methacrylic acid) nanospheres were imprinted with theophylline through template radical polymerisation in diluted acetonitrile solution. This study will focus on the effect of functional monomer nature used (methylmethacrylate and/or methacrylic acid) in the recognition and in the release of template in order to develop a material with combined properties of drug delivery and rebinding for clinical applications. After template extraction the nanospheres showed satisfactory recognition properties (up to 1mg template/g of polymer). Moreover polymers prepared selectively removed theophylline with a theophylline rebinding of 5.1 times higher than that of caffeine, a compound of similar structure. Drug release properties were also satisfactory (up to 95% of loaded theophylline in 7 days).
Ciardelli
G
G
Department of Chemical Engineering, Industrial Chemistry, Materials Science, Via Diotisalvi, 2 56126 Pisa, Italy. gianluca@ing.unipi.it
Cioni
B
B
Cristallini
C
C
Barbani
N
N
Silvestri
D
D
Giusti
P
P
D000180:Acrylic Resins / Q000737:chemistry; D001665:Binding Sites; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods*; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000737:chemistry*; D013499:Surface Properties; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry*; D000099166:Polyacrylamides
D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D003432:Cross-Linking Reagents; D011109:Polymethacrylic Acids; D013806:Theophylline; D000099166:Polyacrylamides; C038300:methylmethacrylate-methacrylic acid copolymer