[Vogt-Koyanagi-Harada Disease: clinical features, therapy and long-term visual outcome in a Caucasian and African population].
OBJECTIVE
Seventeen consecutive cases of Vogt-Koyanagi-Harada (VKH) disease were studied to determine their clinical profile.


METHODS
This was a retrospective study of 17 cases, in a white and African population.


RESULTS
The sex ratio (female/male) was 1.6. Mean age was 37.65 +/- 10.2 years. Eight patients were Caucasian (47%), and seven were from North Africa (41%), and two were black Africans (12%). Eleven patients were referred during the acute stage, and six patients secondarily. All patients had bilateral ocular involvement. Panuveitis with retinal serous detachment was the most frequent presentation (88%). Extraocular signs were found in 87% of the cases. Initial visual acuity was 0.29 +/- 0.36, and final visual acuity was 0.78 +/- 0.3. Patients seen during the acute stage were treated with general corticotherapy. Immunosuppressive agents were given in 56% of the cases.


CONCLUSIONS
Vogt-Koyanagi-Harada disease, in a Caucasian and African population, has a presentation close to that of the Japanese population. However, cutaneous signs are much rarer. Visual prognosis was generally favorable.
Guenoun
J-M
JM
Service d'Ophtalmologie, Hôpital Cochin, Université Paris V, Paris, France.
Parc
C
C
Dhote
R
R
Brezin
A P
AP
D000293:Adolescent; D000328:Adult; D044383:Black People; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis / Q000188:drug therapy; D044465:White People