Ubiquitin-dependent control of development in Saccharomyces cerevisiae.
In response to external environmental stimuli and intrinsic developmental cues, yeast cells reset their gene expression programs and change phenotype. These switches in cellular state require the dismantling of an initial regulatory program, in addition to the induction of different sets of genes to specify the new cell phenotype. Recent experiments examining the role of protein degradation in these transitions have highlighted the importance of inactivating previously utilized regulators and have led to advances in our understanding of how cells change from one phenotypic state to another.
Laney
Jeffrey D
JD
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Box G-J2, Providence, Rhode Island 02912, USA. Jeffrey_laney@brown.edu
Hochstrasser
Mark
M
D015966:Gene Expression Regulation, Fungal; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
D029701:Saccharomyces cerevisiae Proteins; D025801:Ubiquitin