In vitro model of Bartonella henselae-induced angiogenesis.
Bartonella henselae is a gram-negative pathogen that causes angiogenesis. Here, I establish in vitro models to study Bartonella-induced blood vessel formation. I found that B. henselae induces long-term endothelial survival and tubular differentiation within type I collagen matrix.
Kirby
James E
JE
Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Yamins 309, Boston, MA 02215, USA. jekirby@bidmc.harvard.edu
D018416:Bartonella henselae / Q000472:pathogenicity*; D002454:Cell Differentiation; D002470:Cell Survival / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000209:etiology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology
D042461:Vascular Endothelial Growth Factor A; D013755:Tetradecanoylphorbol Acetate