[Meta analysis of relationship between laryngeal tumor of chinese and human papillomavirus infection].
OBJECTIVE
Researches showed that the infection of human papillomavirus (HPV) was closely related to laryngeal tumor, but those results existed great differences because of different research methods. In this study Fisher's and Meta analysis were used to synthetically evaluate relationship between laryngeal benign and malignant tumors of Chinese and infection of different types of HPV.


METHODS
A total of 123 references about relationship between laryngeal benign and malignant tumors of Chinese and infection of different types of HPV were collected from CBMdisc (Chinese Biomedical Literature Analysis and Retrieval System for Compact Disc). There were 11 references accorded with research criteria which were case-control study, and had detected HPV16 or HPV6/11 by polymerase chain reaction (PCR). Fisher and Meta analysis were used to quantitatively and qualitatively analyze these references synthetically.


RESULTS
Mean detection rates of HPV16 in normal laryngeal tissue, laryngeal carcinoma (LC), laryngeal papilloma(LPa), laryngeal polyp (LPo) from all references were 10.8%,35.2%,27.5%,5.0%, respectively; and those of HPV6/11 were 8.7%, 18.6%, 61.6%, 21.9%, respectively. The infection of HPV16 in LC were significantly higher than those in LPa, and LPo (P< 0.005); the combined odds ratio (ORc) for HPV16 infection in LC was 2.8 (1.7-4.7) times that in LPa, and 12.7 (4.2-38.8) times that in LPo; mean positive rate of HPV16 in LC was 22.0% (12.2%-31.8%) higher than that in LPa, and 39.0% (19.4%-58.6%) higher than that in Lpo. The infection of HPV6/11 in LPa was significantly higher than that in LC (P< 0.005); OR(c) for HPV16 infection in LPa was 16.4 (5.6-48.1) times that LC; mean positive rate of HPV16 in LPa was 56.0% (34.4%-75.6%) higher than that in LC. There was no significant difference of HPV6/11 infection between LC and LPo (P >0.05).


CONCLUSIONS
The infection of HPV16 may enhance risk of development of laryngeal carcinoma; and the infection of HPV6/11 may enhance risk of development of laryngeal papilloma.
Chai
Li-Ping
LP
Hospital of Otorhinolaryngology, The First Affiliated Hospital, Research Institute of Otorhinolaryngology, Sun Yat-sen University, Guangzhou, Guangdong, 510080, P.R.China. gzclp@sohu.com
Su
Zhen-Zhong
ZZ
Lei
Wen-Bin
WB
Liang
Wei-Ying
WY
D002294:Carcinoma, Squamous Cell / Q000821:virology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000821:virology*; D015201:Meta-Analysis as Topic; D010212:Papilloma / Q000821:virology; D027383:Papillomaviridae / Q000145:classification; D030361:Papillomavirus Infections; D012307:Risk Factors