Synthesis, antitumour and antimicrobial activities of new peptidyl derivatives containing the 1,3-benzodioxole system.
Two series of 5 and 6-substituted 1,3-benzodioxole peptidyl derivatives were synthesized and evaluated as antitumour and antimicrobial agents. The compounds that could be conveniently prepared in a few steps processes from natural safrole have been characterised by IR and 1H-NMR spectroscopy. In vivo antitumor activity tests showed that some of the compounds were able to inhibit carcinoma S-180 tumour growth in mice. The in vitro antimicrobial activity of all compounds revealed that they are able to promote the growth of some organisms, including Bacillus subtilis.
Leite
Ana Cristina Lima
AC
Labsinfa, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco--Rua Prof. Artur Sá S/N, CDU, 50740-520, Recife, Pernambuco, Brazil. aclb@ufpe.br
da Silva
Kezia Peixoto
KP
de Souza
Ivone A
IA
de Araújo
Janete Magali
JM
Brondani
Dalci José
DJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D001522:Behavior, Animal / Q000187:drug effects; D004149:Dioxoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D051379:Mice; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D012451:Safrole / Q000737:chemistry; D012510:Sarcoma 180 / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004149:Dioxoles; C496326:N-(6-allyl-1,3-benzodioxol-5-yl)-N-(tert-butoxycarbonyl)phenylalaninamide; D010455:Peptides; D010649:Phenylalanine; D012451:Safrole