title: Changes in metal levels and chromosome aberrations in the peripheral blood of patients after metal-on-metal hip arthroplasty.
abstract: A prospective study was performed to investigate changes in metal levels and chromosome aberrations in patients within 2 years of receiving metal-on-metal hip arthroplasties. There was a statistically significant increase of cobalt and chromium concentrations, with a small increase in molybdenum, in whole blood at 6, 12, and 24 months after surgery. There was also a statistically significant increase of both chromosome translocations and aneuploidy in peripheral blood lymphocytes at 6, 12, and 24 months after surgery. The changes were generally progressive with time, but the change in aneuploidy was much greater than in chromosome translocations. No statistically significant correlations were found in secondary analyses between chromosome translocation indices and cobalt or chromium concentration in whole blood. Although the clinical consequences of these changes, if any, are unknown, future epidemiological studies could usefully include direct comparisons of patients with implants of different composition.
authors.affiliation: University of Bristol, Orthopaedic Surgery, BIRC-Bristol Implant Research Center, Bristol, UK.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Ladon
authors.forename: Ann
authors.initials: A
authors.lastname: Doherty
authors.forename: Roger
authors.initials: R
authors.lastname: Newson
authors.forename: Justine
authors.initials: J
authors.lastname: Turner
authors.forename: Manjit
authors.initials: M
authors.lastname: Bhamra
authors.forename: C Patrick
authors.initials: CP
authors.lastname: Case
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D002857:Chromium / Q000097:blood; D002869:Chromosome Aberrations; D003035:Cobalt / Q000097:blood; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008670:Metals / Q000097:blood*; D008875:Middle Aged; D008982:Molybdenum / Q000097:blood; D011446:Prospective Studies; D011474:Prosthesis Design; D011475:Prosthesis Failure; D014178:Translocation, Genetic
chemical_list: D008670:Metals; D002857:Chromium; D003035:Cobalt; D008982:Molybdenum