Integrin-growth factor interactions as regulators of oligodendroglial development and function.
Central nervous system (CNS) development requires mechanisms for the regulation of cell number. Although growth factors are essential determinants of the proliferation and apoptosis that determine final numbers, the long-range nature of signals from diffusible growth factors makes them insufficient for the provision of the precise and localized signals required. Integration of integrin and growth factor receptor signaling in controlling cell behavior has been an important theme of research over the past several years. The focus of this review is on the mechanisms by which integrin-growth factor interactions regulate the development of oligodendrocytes and provide a mechanism for controlling, both in space and in time, oligodendrocyte numbers in the developing CNS.
Baron
Wia
W
Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, Groningen, The Netherlands. w.baron@med.rug.nl
Colognato
Holly
H
ffrench-Constant
Charles
C
Ffrench-Constant
Charles
C
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology; D049109:Cell Proliferation; D002490:Central Nervous System / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D009836:Oligodendroglia / Q000166:cytology / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
D006133:Growth Substances; D016023:Integrins