title: Circulation of type 1 vaccine-derived poliovirus in the Philippines in 2001.
abstract: In 2001, highly evolved type 1 circulating vaccine-derived poliovirus (cVDPV) was isolated from three acute flaccid paralysis patients and one contact from three separate communities in the Philippines. Complete genomic sequencing of these four cVDPV isolates revealed that the capsid region was derived from the Sabin 1 vaccine strain but most of the noncapsid region was derived from an unidentified enterovirus unrelated to the oral poliovirus vaccine (OPV) strains. The sequences of the cVDPV isolates were closely related to each other, and the isolates had a common recombination site. Most of the genetic and biological properties of the cVDPV isolates were indistinguishable from those of wild polioviruses. However, the most recently identified cVDPV isolate from a healthy contact retained the temperature sensitivity and partial attenuation phenotypes. The sequence relationships among the isolates and Sabin 1 suggested that cVDPV originated from an OPV dose given in 1998 to 1999 and that cVDPV circulated along a narrow chain of transmission. Type 1 cVDPV was last detected in the Philippines in September 2001, and population immunity to polio was raised by extensive OPV campaigns in late 2001 and early 2002.
authors.affiliation: Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan. hshimizu@nih.go.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Bruce
authors.initials: B
authors.lastname: Thorley
authors.forename: Fem Julia
authors.initials: FJ
authors.lastname: Paladin
authors.forename: Kerri Anne
authors.initials: KA
authors.lastname: Brussen
authors.forename: Vicki
authors.initials: V
authors.lastname: Stambos
authors.forename: Lilly
authors.initials: L
authors.lastname: Yuen
authors.forename: Andi
authors.initials: A
authors.lastname: Utama
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tano
authors.forename: Minetaro
authors.initials: M
authors.lastname: Arita
authors.forename: Hiromu
authors.initials: H
authors.lastname: Yoshida
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Yoneyama
authors.forename: Agnes
authors.initials: A
authors.lastname: Benegas
authors.forename: Sigrun
authors.initials: S
authors.lastname: Roesel
authors.forename: Mark
authors.initials: M
authors.lastname: Pallansch
authors.forename: Olen
authors.initials: O
authors.lastname: Kew
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Miyamura
mesh_terms: D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D004770:Enterovirus / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008969:Molecular Sequence Data; D010679:Philippines / Q000453:epidemiology; D010802:Phylogeny; D011051:Poliomyelitis / Q000453:epidemiology* / Q000821:virology*; D017955:Poliovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D011055:Poliovirus Vaccine, Oral; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D011055:Poliovirus Vaccine, Oral