title: Tumid lupus erythematosus occurring following highly active antiretroviral therapy for HIV infection: a manifestation of immune restoration.
abstract: Tumid lupus erythematosus (LE) is a relatively rare and only recently recognized subset of chronic cutaneous lupus. We report a case occurring in a male with HIV infection whereby his rash was only unmasked by immune restoration following highly active antiretroviral therapy (HAART). The phenomenon of latent inflammatory or autoimmune disease appearing following HAART is now recognized as the "immune restoration syndrome" and tumid LE has not been reported in this setting previously. Fortunately this variant of lupus does not result in scarring and is responsive to anti-malarials, allowing continuation of HAART in this patient.
authors.affiliation: Department of Dermatology, Oxford Radcliffe Hospitals, Oxford, United Kingdom. richard.turner@orh.nhs.uk
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Chamberlain
authors.forename: Kevin
authors.initials: K
authors.lastname: Hollowood
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Turner
authors.forename: Ivor
authors.initials: I
authors.lastname: Byren
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D003879:Dermatologic Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007121:Immunocompetence; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy / Q000276:immunology*; D008297:Male
chemical_list: D003879:Dermatologic Agents; D006886:Hydroxychloroquine