Efficient synthesis of 4-aminoquinazoline and thieno[3,2-d]pyrimidin-4-ylamine derivatives by microwave irradiation.
[reaction: see text] A simple, efficient, and high-yielding synthesis of quinazolin-4-ylamine and thieno[3,2-d]pyrimidin-4-ylamine derivatives is reported under microwave irradiation conditions. Reaction conditions including temperature, solvent, and reaction time have been studied. An efficient parallel workup procedure was developed to generate a small library (23 compounds) in a short time period.
Yoon
David S
DS
Albany Molecular Research, Inc., 21 Corporate Circle, Albany, New York 12212-5098, USA.
Han
Ying
Y
Stark
Todd M
TM
Haber
James C
JC
Gregg
Brian T
BT
Stankovich
Sara B
SB