Effect of the interleukin-1 genotype on outcomes of regenerative periodontal therapy with bone replacement grafts.
BACKGROUND
Previous studies have shown an association between a specific genotype for the inflammatory cytokine interleukin (IL)-1 and the severity of periodontal disease. The purpose of this study was to evaluate the effect of the IL-1 genotype on the outcomes of periodontal surgical regenerative treatment with bone replacement grafts.


METHODS
Forty-four patients with interproximal intrabony defects were treated with bone replacement grafts. Probing depths (PD) and clinical attachment levels (CAL) were measured before treatment and at least 9 months post-treatment. Whole-mouth plaque index (WMPI) and bleeding index (WMBI) were recorded as well. All patients were tested for the IL-1 genotype.


RESULTS
Thirteen (29.55%) of the patients were IL-1 genotype positive. There was no statistically significant difference between the genotype-positive and genotype-negative groups regarding age, smoking status, gender, WMPI, and WMBI. There was no significant difference in PD or CAL between the genotype-positive and genotype-negative groups at baseline. Genotype-positive patients had a smaller reduction in probing depth (1.86 mm versus 2.13 mm) and a greater gain of clinical attachment (1.20 mm versus 0.65 mm). These differences were not statistically significant (P = 0.70, P = 0.40). Multivariate regression analysis showed that presurgical PD significantly influenced post-surgical PD and CAL, and only WMPI significantly influenced CAL.


CONCLUSIONS
In this study, there was no evidence that the IL-1 genotype influences the clinical treatment outcomes of regenerative periodontal therapy with bone replacement grafts.
Weiss
Oren I
OI
Division of Periodontics, Eastman Department of Dentistry, University of Rochester Eastman Dental Center, Rochester, NY 14620, USA. Oren_Weiss@urmc.rochester.edu
Caton
Jack
J
Blieden
Timothy
T
Fisher
Susan G
SG
Trafton
Sarah
S
Hart
Thomas C
TC
D000328:Adult; D000367:Age Factors; D000368:Aged; D000483:Alleles; D016301:Alveolar Bone Loss / Q000601:surgery*; D001861:Bone Regeneration / Q000235:genetics*; D016025:Bone Transplantation; D002874:Chromosome Mapping; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D012189:Retrospective Studies; D012737:Sex Factors; D012907:Smoking; D016896:Treatment Outcome
D007375:Interleukin-1