Tosylation of endocrine-disruptive alkylphenolic compounds in a solid-phase reaction system consisting of C18-modified silica gel and aqueous buffer solution.
The tosylation reaction of endocrine-disruptive alkylphenolic compounds in a solid-phase aqueous system was investigated with the aim of developing an environment-friendly and efficient derivatization method for HPLC analyses of environmental samples. The phenols were rapidly and efficiently converted to the tosyl derivatives on a commercially available ODS solid-phase cartridge by passing an aqueous buffer solution through it. The solid-phase aqueous tosylation system has been incorporated into a preconcentration step performed by solid-phase extraction from environmental water.
Uno
Bunji
B
Gifu Pharmaceutical University, Mitahora-higashi, Gifu, Japan. uno@gifu-pu.ac.jp
Okumura
Noriko
N
D002021:Buffers; D002851:Chromatography, High Pressure Liquid; D004702:Endocrine Glands / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D010636:Phenols / Q000737:chemistry*; D058428:Silica Gel; D012822:Silicon Dioxide; D013056:Spectrophotometry, Ultraviolet; D014105:Tosyl Compounds / Q000737:chemistry*
D002021:Buffers; D010636:Phenols; D014105:Tosyl Compounds; D058428:Silica Gel; D012822:Silicon Dioxide