Cyclosporin-augmented laser peripheral iridoplasty.
OBJECTIVE
Almost all patients develop iritis following argon laser peripheral iridoplasty. Numerous adverse effects, particularly elevated intraocular pressure (IOP) and reduced microbial resistance, complicate therapy with topical corticosteroids. An immunomodulator, such as cyclosporin A (CsA), avoids these undesirable effects, yet may suppress ocular inflammation.


METHODS
Argon laser peripheral iridoplasty was performed on anesthetized rabbits with pigmented iris epithelium. Rabbits were randomly assigned to the untreated control, CsA (2%), or dexamethasone (0.1%) groups. Postoperative inflammation was documented by digital photography, IOP, and protein in aqueous humor.


RESULTS
Iris injection, aqueous flare, and fibrin decreased most rapidly in the control group, as did protein in aqueous humor. Decreases in IOP of 49% to 58% were similar in all three groups. There were no differences in conjunctival congestion between the


CONCLUSIONS
Neither treatment with antiinflammatory drugs that inhibit phagocytosis (e.g., topical steroids) nor treatment with anti-inflammatory drugs that suppress T-lymphocytes (e.g., topical sA) significantly attenuated inflammation following iridoplasty.
Crouch
Earl R
ER
Thomas R. Lee Center for Ocular Pharmacology, Eastern Virginia Medical School, Norfolk, VA 23501, USA.
Lattanzio
Frank A
FA
Williams
Patricia B
PB
Mitrev
Peter V
PV
Theobald
Todd
T
Allen
Robert C
RC
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use; D005136:Eye Proteins / Q000378:metabolism; D005938:Glucocorticoids / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007429:Intraocular Pressure; D032801:Iridectomy; D007498:Iris / Q000187:drug effects* / Q000601:surgery*; D007500:Iritis / Q000517:prevention & control; D053685:Laser Therapy / Q000379:methods*; D011817:Rabbits
D005136:Eye Proteins; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003907:Dexamethasone; D016572:Cyclosporine