title: HIV viral shedding in semen: lack of correlation with systemic virus-specific CD8 responses.
abstract: Semen is a major transmission vector for HIV. Virus-specific CD8 T cells are critical in HIV control, but their relationship with semen viral load is unknown. We therefore examined the association between systemic HIV-specific IFN-gamma CD8 responses and viral load in the semen and blood of HIV-infected men. No correlation was observed between viral load in either semen or blood and systemic CD8 T-cell responses. Further studies of immune correlates of semen HIV shedding are needed.
authors.affiliation: Department of Medicine, University of Toronto, Toronto, Canada.
authors.forename: Prameet M
authors.initials: PM
authors.lastname: Sheth
authors.forename: Kamnoosh
authors.initials: K
authors.lastname: Shahabi
authors.forename: Anuradha
authors.initials: A
authors.lastname: Rebbapragada
authors.forename: Colin
authors.initials: C
authors.lastname: Kovacs
authors.forename: Rowena
authors.initials: R
authors.lastname: Dimayuga
authors.forename: Sharon
authors.initials: S
authors.lastname: Chackalakkal
authors.forename: Kelly
authors.initials: K
authors.lastname: MacDonald
authors.forename: Tony
authors.initials: T
authors.lastname: Mazzulli
authors.forename: Rupert
authors.initials: R
authors.lastname: Kaul
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000635:transmission*; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D012313:RNA / Q000032:analysis / Q000097:blood; D012661:Semen / Q000821:virology*; D019562:Viral Load; D017201:Virus Shedding
chemical_list: D012313:RNA