Immune evasion of the Lyme disease spirochetes.
The Lyme disease spirochetes, Borrelia burgdorferi sensu lato, have adapted very well to both surviving and persisting in the mammalian host despite a strong host antibody response. It appears that both temporal and spatial regulation of outer surface proteins have contributed to this persistence. The spirochetes are able to bind fH and FHL-1 to their surface, resulting in decreased complement activation. In addition, the organisms have taken advantage of components of tick saliva to aid in their initial immune evasion and dissemination. Studies leading to these conclusions are reviewed here.
Bubeck-Martinez
Sarah
S
Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. martinezsb@uthscsa.edu <martinezsb@uthscsa.edu>
D000818:Animals; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D025065:Borrelia burgdorferi / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D008193:Lyme Disease / Q000276:immunology*; D051379:Mice; D013144:Spirochaetales / Q000378:metabolism*; D013987:Ticks
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D008074:Lipoproteins; C079616:OspC protein; C105546:VlsE protein, Borrelia burgdorferi