Pseudoprolines as removable turn inducers: tools for the cyclization of small peptides.
The cyclization of small peptides which do not incorporate turn inducers is often difficult. We have developed a method involving the use of removable turn inducers, in the form of pseudoprolines, for the cyclization of difficult peptide sequences. The pseudoprolines induce a cisoid amide bond in the peptide backbone which facilitates cyclization. They are then readily removed to yield a cyclic peptide that does not contain any turn inducers.
Skropeta
Danielle
D
School of Chemistry, The University of Sydney, 2006 NSW, Australia.
Jolliffe
Katrina A
KA
Turner
Peter
P
D003500:Cyclization; D008958:Models, Molecular; D008968:Molecular Conformation; D010455:Peptides / Q000138:chemical synthesis*; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry*
D010455:Peptides; D011392:Proline