[Reactivity of Candida albicans in the system of the alternative way of complement activation].
The neutrophil-stimulating activity of C. albicans before and after opsonization in the system of the alternative way of complement activation (AWCA) was studied. The study revealed that, in comparison with zymosan, C. albicans exhibited a considerably lower index of AWCA-dependent opsonic effect in reaction with neutrophils. This did not correlate with the capacity of substrates to activate the alternative cascade and with the intensity of phagocytosis. The suggestion on the involvement of C. albicans thermolabile cell-wall components into the negative regulation AWCA-dependent opsonic effect was substantiated.
Zaslavskaia
M I
MI
Makhrova
T V
TV
Maianskiĭ
A N
AN
D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology*; D003170:Complement Pathway, Alternative; D003165:Complement System Proteins / Q000276:immunology*; D006801:Humans; D009504:Neutrophils / Q000276:immunology / Q000382:microbiology; D009895:Opsonin Proteins; D010587:Phagocytosis / Q000276:immunology
D009895:Opsonin Proteins; D003165:Complement System Proteins