Determinants of immune reconstitution inflammatory syndrome in HIV type 1-infected patients with tuberculosis after initiation of antiretroviral therapy.
Immune reconstitution inflammatory syndrome (IRIS) occurred in 16 of 37 antiretroviral-naive patients who were treated subsequently for tuberculosis and human immunodeficiency virus (HIV) type 1 infection. IRIS was related to increases in the CD4 cell percentage and in the ratio of CD4 cells to CD8 cells after 1 month of antiretroviral therapy and to dissemination of tuberculosis. These results have implications for the diagnosis of IRIS and the understanding of its pathogenesis.
Breton
Guillaume
G
Department of Infectious and Tropical Diseases, INSERM E0357, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. guillaume.breton@bch.ap-hop-paris.fr
Duval
Xavier
X
Estellat
Candice
C
Poaletti
Xavier
X
Bonnet
Daniel
D
Mvondo Mvondo
David
D
Longuet
Pascale
P
Leport
Catherine
C
Vildé
Jean-Louis
JL
D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013577:Syndrome; D014376:Tuberculosis / Q000150:complications / Q000276:immunology*
D044966:Anti-Retroviral Agents