title: Causes of death in HIV infection: the key determinant to define the clinical response to anti-HIV therapy.
abstract: Studies have shown an increased risk of new AIDS/death among injecting drug users (IDU) starting highly active antiretroviral therapy (HAART). Of 3872 patients starting HAART in the EuroSIDA study, 819 were IDU (21.2%). During 14 769 person-years of follow-up, 499 patients progressed to new AIDS/death. Compared with homosexual individuals, IDU had an increased incidence of new AIDS/death, but only for non-HIV deaths. There is an urgent need to define and standardize causes of death in observational studies.
authors.affiliation: Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK.
authors.forename: Amanda
authors.initials: A
authors.lastname: Mocroft
authors.forename: Jose
authors.initials: J
authors.lastname: Gatell
authors.forename: Peter
authors.initials: P
authors.lastname: Reiss
authors.forename: Bruno
authors.initials: B
authors.lastname: Ledergerber
authors.forename: Ole
authors.initials: O
authors.lastname: Kirk
authors.forename: Stefano
authors.initials: S
authors.lastname: Vella
authors.forename: Anders
authors.initials: A
authors.lastname: Blaxhult
authors.forename: Andrew N
authors.initials: AN
authors.lastname: Phillips
authors.forename: Jens
authors.initials: J
authors.lastname: Lundgren
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy / Q000401:mortality; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D015331:Cohort Studies; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000401:mortality*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D006716:Homosexuality; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000401:mortality*
chemical_list: D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors