Effects of indole fatty alcohols on the differentiation of neural stem cell derived neurospheres.
In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared. 13c (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.
Coowar
Djalil
D
Laboratoire de Chimie Organique des Substances Naturelles, UMR 7123 CNRS, Université Louis Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg, France.
Bouissac
Julien
J
Hanbali
Mazen
M
Paschaki
Marie
M
Mohier
Eliane
E
Luu
Bang
B
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D052160:Benzothiazoles; D002454:Cell Differentiation / Q000187:drug effects; D005233:Fatty Alcohols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D051379:Mice; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics; D051881:Receptor, Notch1; D051883:Receptor, Notch2; D000074562:Receptor, Notch4; D011956:Receptors, Cell Surface / Q000096:biosynthesis / Q000235:genetics; D051880:Receptors, Notch; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000737:chemistry; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics; D014158:Transcription, Genetic
C494720:10-(5-methoxy-1H-indol-3-yl)decan-1-ol; D000438:Alcohols; D052160:Benzothiazoles; D005233:Fatty Alcohols; D016166:Free Radical Scavengers; D005609:Free Radicals; D007211:Indoles; D008565:Membrane Proteins; C106075:NOTCH4 protein, human; C497762:Notch1 protein, mouse; C497765:Notch2 protein, mouse; D016376:Oligonucleotides, Antisense; D011518:Proto-Oncogene Proteins; D051881:Receptor, Notch1; D051883:Receptor, Notch2; D000074562:Receptor, Notch4; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D013451:Sulfonic Acids; D014157:Transcription Factors; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid