title: Conventional and molecular epidemiology of tuberculosis in homeless patients in Budapest, Hungary.
abstract: In Hungary the incidence of tuberculosis among the homeless population was 676 per 100,000 in 2002. Sixty-nine percent (140 patients) of all homeless tuberculosis patients were notified in Budapest (the capital). Therefore, a retrospective study that included 66 homeless tuberculosis patients notified in Budapest in 2002 was conducted to determine the rate of recent transmission of the disease and medical risk factors and to identify transmission pathways by means of conventional and molecular epidemiologic methods. IS6110 DNA fingerprinting revealed that 71.2% of the isolates could be clustered. Thirty-four (51.5%) patients belonged to five major clusters (size, from 4 to 11 individuals), and 13 (19.7%) belonged to six smaller clusters. Additional analysis of patient records found that 2 (18%) of the 11 patients in cluster A, 3 (37.5%) of the 8 patients in cluster B, and 2 (33%) of the 6 patients in cluster C were residents of the same three homeless shelters during the diagnosis of tuberculosis. Review of the database of the National Tuberculosis Surveillance Center (NTSC) revealed that 21.2% of the cases have not been reported to the NTSC. These findings indicate that the screening and treatment of tuberculosis among the homeless need to be strengthened and also warrant the review of environmental control steps in public shelters. Improvement of adherence of clinicians to surveillance reporting regulations is also necessary.
authors.affiliation: Department of Respiratory Medicine, School of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Lukács
authors.forename: Vilmos
authors.initials: V
authors.lastname: Tubak
authors.forename: Judit
authors.initials: J
authors.lastname: Mester
authors.forename: Sándor
authors.initials: S
authors.lastname: Dávid
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Bártfai
authors.forename: Tanja
authors.initials: T
authors.lastname: Kubica
authors.forename: Stefan
authors.initials: S
authors.lastname: Niemann
authors.forename: Akos
authors.initials: A
authors.lastname: Somoskövi
mesh_terms: D000328:Adult; D000368:Aged; D016172:DNA Fingerprinting / Q000379:methods; D004251:DNA Transposable Elements; D005260:Female; D006703:Ill-Housed Persons; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification; D011159:Population Surveillance; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D004251:DNA Transposable Elements