title: Immunoglobulins in nasal secretions of dog puppies from birth to six weeks of age.
abstract: In order to investigate local immune defence mechanisms in the dog, the concentration of immunoglobulins (Ig) G, A and M in nasal secretions (NS) and serum of 42 healthy, neonatal Rottweiler puppies was determined. Ig were measured with a commercially available, dog-specific ELISA during the first six weeks of life. On average, IgG was the predominant Ig isotype during the first three days of life. The IgA:IgG ratio changed between weeks 1 and 3 due to markedly decreasing IgG concentrations. Between the fourth and sixth week, IgG predominated again. During the first week, only 21-39% of puppies had measurable amounts of IgM in NS, in week 2, this percentage increased to 69%. Marked differences between litters and between individual puppies within litters were found. No puppy diseased during the observation period and all developed normally.
authors.affiliation: Department for Animal Breeding and Reproduction, Clinic for Obstetrics, Gynaecology and Andrology, University of Veterinary Sciences, Veterinärplatz 1, 1210 Vienna, Austria. sabine.schaefer@vu-wien.ac.at
authors.forename: Sabine
authors.initials: S
authors.lastname: Schäfer-Somi
authors.forename: Sabine
authors.initials: S
authors.lastname: Bär-Schadler
authors.forename: Jörg E
authors.initials: JE
authors.lastname: Aurich
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000276:immunology; D003126:Colostrum / Q000276:immunology; D004285:Dogs / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D007132:Immunoglobulin Isotypes / Q000097:blood / Q000276:immunology*; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology*; D008297:Male; D008892:Milk / Q000276:immunology; D009297:Nasal Mucosa / Q000276:immunology*; D018709:Statistics, Nonparametric
chemical_list: D007132:Immunoglobulin Isotypes; D007136:Immunoglobulins