title: 10-membered macrolides from the insect pathogenic fungus Cordyceps militaris BCC 2816.
abstract: Three new 10-membered macrolides (1-3) have been isolated from the entomopathogenic fungus Cordyceps militaris BCC 2816, together with six known compounds, cepharosporolides C (4), E (5), and F (6), 2-carboxymethyl-4-(3'-hydroxybutyl)furan (7), cordycepin (8), and pyridine-2,6-dicarboxylic acid. The structures were determined by analysis of NMR data, and an X-ray analysis was performed to confirm the structure of 1. The antimalarial activity of 1-4 and 8 against Plasmodium falciparum K1 was evaluated.
authors.affiliation: Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand. vatcharin.r@psu.ac.th
authors.forename: Vatcharin
authors.initials: V
authors.lastname: Rukachaisirikul
authors.forename: Songyos
authors.initials: S
authors.lastname: Pramjit
authors.forename: Chaveng
authors.initials: C
authors.lastname: Pakawatchai
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
authors.forename: Sumalee
authors.initials: S
authors.lastname: Supothina
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032661:Cordyceps / Q000737:chemistry*; D018360:Crystallography, X-Ray; D018432:Drug Resistance, Multiple; D020128:Inhibitory Concentration 50; D007313:Insecta; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects*; D013785:Thailand
chemical_list: D000962:Antimalarials; D018942:Macrolides