title: Reduction of clinical tuberculosis in HIV-infected males with isoniazid prophylaxis.
abstract: Isoniazid (INH) chemoprophylaxis has a positive impact on the development of clinical tuberculosis. Due to the increased prevalence of tuberculosis among HIV-infected individuals, we evaluated the effect of INH on the prevention of clinical tuberculosis in HIV-infected patients. We administered 300 mg of INH daily to 246 HIV-infected, tuberculin skin test-positive patients for 12 months. During 3 years of follow-up, 41 participants died and 94 were lost to follow up. Of the 111 patients followed for the 3 years, 12 developed tuberculosis which is lower than might be expected in an untreated group. INH prophylaxis appears to be an effective method to prevent clinical tuberculosis among HIV-infected, tuberculin skin test-positive patients.
authors.affiliation: HIV/STI/DU Counselling and Care Centre, Medical University of Kermanshah, Kermanshah, Islamic Republic of Iran.
authors.forename: K
authors.initials: K
authors.lastname: Alaei
authors.forename: A
authors.initials: A
authors.lastname: Alaei
authors.forename: D
authors.initials: D
authors.lastname: Mansouri
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D018890:Chemoprevention / Q000379:methods / Q000592:standards; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D007538:Isoniazid / Q000627:therapeutic use*; D008297:Male; D015995:Prevalence; D011329:Prisoners / Q000706:statistics & numerical data; D011446:Prospective Studies; D012307:Risk Factors; D012882:Skin Tests; D015819:Substance Abuse, Intravenous / Q000150:complications; D016896:Treatment Outcome; D014373:Tuberculin; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D014505:Urban Population / Q000706:statistics & numerical data
chemical_list: D000995:Antitubercular Agents; D014373:Tuberculin; D007538:Isoniazid