title: Pharmacokinetics and pharmacodynamics of febuxostat (TMX-67), a non-purine selective inhibitor of xanthine oxidase/xanthine dehydrogenase (NPSIXO) in patients with gout and/or hyperuricemia.
abstract: The diurnal change of sUA and the effect of febuxostat on this change were investigated in 10 patients with gout and/or hyperuricemia. The diurnal sUA change after the last dose during the 4-week treatment phase (20 mg, QD) was almost the same as the pre-treatment value. Considering the dose, the AUC(obs) and Cmax of unchanged drug in patients with gout and/or hyperuricemia were estimated to be similar to those of healthy male adults. The results show that a 6-week treatment with febuxostat is safe and well-tolerated in the target patient population for this drug.
authors.affiliation: Teijin Ltd., Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Komoriya
authors.forename: S
authors.initials: S
authors.lastname: Hoshide
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: J
authors.initials: J
authors.lastname: Kubo
authors.forename: M
authors.initials: M
authors.lastname: Tsuchimoto
authors.forename: T
authors.initials: T
authors.lastname: Nakachi
authors.forename: H
authors.initials: H
authors.lastname: Yamanaka
authors.forename: N
authors.initials: N
authors.lastname: Kamatani
mesh_terms: D019540:Area Under Curve; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D000069465:Febuxostat; D006073:Gout / Q000188:drug therapy*; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy*; D008297:Male; D010100:Oxygen / Q000378:metabolism; D013844:Thiazoles / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D013997:Time Factors; D014968:Xanthine Dehydrogenase / Q000037:antagonists & inhibitors; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
chemical_list: D004791:Enzyme Inhibitors; D013844:Thiazoles; D000069465:Febuxostat; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase; D010100:Oxygen