Two tonB systems function in iron transport in Vibrio anguillarum, but only one is essential for virulence.
We have identified two functional tonB systems in the marine fish pathogen Vibrio anguillarum, tonB1 and tonB2. Each of the tonB genes is transcribed in an operon with the cognate exbB and exbD genes in response to iron limitation. Only tonB2 is essential for transport of ferric anguibactin and virulence.
Stork
Michiel
M
Department of Molecular Microbiology and Immunology, Oregon Health & Science University, SW Sam Jackson Park Road, Portland, OR 97239, USA.
Di Lorenzo
Manuela
M
Mouriño
Susana
S
Osorio
Carlos R
CR
Lemos
Manuel L
ML
Crosa
Jorge H
JH
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D001692:Biological Transport; D015964:Gene Expression Regulation, Bacterial; D007501:Iron / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D010455:Peptides / Q000378:metabolism; D014733:Vibrio / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
D001426:Bacterial Proteins; D008565:Membrane Proteins; D010455:Peptides; C057616:tonB protein, Bacteria; C049469:anguibactin; D007501:Iron