title: Cyclosporin-augmented laser peripheral iridoplasty.
abstract: OBJECTIVE
  Almost all patients develop iritis following argon laser peripheral iridoplasty. Numerous adverse effects, particularly elevated intraocular pressure (IOP) and reduced microbial resistance, complicate therapy with topical corticosteroids. An immunomodulator, such as cyclosporin A (CsA), avoids these undesirable effects, yet may suppress ocular inflammation.
  
  
  METHODS
  Argon laser peripheral iridoplasty was performed on anesthetized rabbits with pigmented iris epithelium. Rabbits were randomly assigned to the untreated control, CsA (2%), or dexamethasone (0.1%) groups. Postoperative inflammation was documented by digital photography, IOP, and protein in aqueous humor.
  
  
  RESULTS
  Iris injection, aqueous flare, and fibrin decreased most rapidly in the control group, as did protein in aqueous humor. Decreases in IOP of 49% to 58% were similar in all three groups. There were no differences in conjunctival congestion between the
  
  
  CONCLUSIONS
  Neither treatment with antiinflammatory drugs that inhibit phagocytosis (e.g., topical steroids) nor treatment with anti-inflammatory drugs that suppress T-lymphocytes (e.g., topical sA) significantly attenuated inflammation following iridoplasty.
authors.affiliation: Thomas R. Lee Center for Ocular Pharmacology, Eastern Virginia Medical School, Norfolk, VA 23501, USA.
authors.forename: Earl R
authors.initials: ER
authors.lastname: Crouch
authors.forename: Frank A
authors.initials: FA
authors.lastname: Lattanzio
authors.forename: Patricia B
authors.initials: PB
authors.lastname: Williams
authors.forename: Peter V
authors.initials: PV
authors.lastname: Mitrev
authors.forename: Todd
authors.initials: T
authors.lastname: Theobald
authors.forename: Robert C
authors.initials: RC
authors.lastname: Allen
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use; D005136:Eye Proteins / Q000378:metabolism; D005938:Glucocorticoids / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007429:Intraocular Pressure; D032801:Iridectomy; D007498:Iris / Q000187:drug effects* / Q000601:surgery*; D007500:Iritis / Q000517:prevention & control; D053685:Laser Therapy / Q000379:methods*; D011817:Rabbits
chemical_list: D005136:Eye Proteins; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003907:Dexamethasone; D016572:Cyclosporine