Optimization of pyrrolidinone based HIV protease inhibitors.
Optimization of P1-substituted pyrrolidinone based HIV protease inhibitors has yielded analogs with very potent antiviral activity.
Sherrill
Ronald G
RG
GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. ron.g.sherrill@gsk.com
Andrews
C Webster
CW
Bock
William J
WJ
Davis-Ward
Ronda G
RG
Furfine
Eric S
ES
Hazen
Richard J
RJ
Rutkowske
Randy D
RD
Spaltenstein
Andrew
A
Wright
Lois L
LL
D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology*
D017320:HIV Protease Inhibitors; D011760:Pyrrolidinones