Gene map of the extended human MHC.
The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in adaptive and innate immunity. Decades of biomedical research have revealed many MHC genes that are duplicated, polymorphic and associated with more diseases than any other region of the human genome. The recent completion of several large-scale studies offers the opportunity to assimilate the latest data into an integrated gene map of the extended human MHC. Here, we present this map and review its content in relation to paralogy, polymorphism, immune function and disease.
Horton
Roger
R
Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Wilming
Laurens
L
Rand
Vikki
V
Lovering
Ruth C
RC
Bruford
Elspeth A
EA
Khodiyar
Varsha K
VK
Lush
Michael J
MJ
Povey
Sue
S
Talbot
C Conover
CC
Wright
Mathew W
MW
Wain
Hester M
HM
Trowsdale
John
J
Ziegler
Andreas
A
Beck
Stephan
S
D001327:Autoimmune Diseases / Q000235:genetics; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D015894:Genome, Human; D006801:Humans; D007109:Immunity; D008285:Major Histocompatibility Complex; D005810:Multigene Family; D011110:Polymorphism, Genetic; D012343:RNA, Transfer / Q000235:genetics
D012343:RNA, Transfer