Does the placenta inhibit the passage of chromium and cobalt after metal-on-metal total hip arthroplasty?
Umbilical cord serum and corresponding maternal serum of 3 women with uncemented metal-on-metal total hip arthroplasties were analyzed for cobalt and chromium. The women were an average 3.8 (range, 2-5) years after hip surgery. At the time of delivery, the maternal chromium concentrations were 1.6 microg/l, 0.5 microg/l, and 0.9 microg/l, respectively, and the maternal cobalt concentration was 1 microg/l in the first woman and below the detection limit in the other 2 women. Cobalt and chromium concentrations of the 3 umbilical cord sera also were below the detection limit. This indicates that-with regard to the detection limit of our laboratory-we were unable to observe a passage of cobalt and chromium ions from metal-on-metal articulations across the placenta at the time of delivery.
Brodner
Wolfram
W
Department of Orthopaedics, Vienna General Hospital and Medical University of Vienna, Vienna, Austria.
Grohs
Josef Georg
JG
Bancher-Todesca
Dagmar
D
Dorotka
Ronald
R
Meisinger
Vanee
V
Gottsauner-Wolf
Florian
F
Kotz
Rainer
R
D019644:Arthroplasty, Replacement, Hip; D002857:Chromium / Q000097:blood / Q000378:metabolism*; D003035:Cobalt / Q000097:blood / Q000378:metabolism*; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011474:Prosthesis Design
D002857:Chromium; D003035:Cobalt