5'-Homoaristeromycin. Synthesis and antiviral activity against orthopox viruses.
An efficient synthesis of 5'-homoaristeromycin has been developed. This permitted an extensive antiviral analysis, which found potent activity toward vaccinia, cowpox, and monkeypox viruses. For comparative purposes, 5'-homoadenosine was made available by a newly designed route and found to be inactive.
Yang
Minmin
M
Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA.
Schneller
Stewart W
SW
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D018155:Orthopoxvirus / Q000187:drug effects*
C500020:5'-homoaristeromycin; D000998:Antiviral Agents; D000241:Adenosine