title: Prevalence of mild cognitive impairment in 60- to 64-year-old community-dwelling individuals: The Personality and Total Health through Life 60+ Study.
abstract: This epidemiological study aimed at determining the prevalence of mild cognitive impairment (MCI) in 60- to 64-year-old individuals using different diagnostic criteria. Community dwelling individuals (n = 2,551) in the age range of 60-64 years were recruited randomly through the electoral roll. They were screened using the MMSE and a short cognitive battery, and those who screened positive underwent detailed medical and cognitive assessments. Extant MCI-related diagnoses were established by consensus. Predictive regression models on the sub-sample were used to determine population prevalence for the diagnoses. Of the 224 subjects who screened positive for MCI, 112 underwent a detailed assessment and 74% met the criteria for at least one recognised diagnosis of mild cognitive deficit (MCI and related diagnoses). By predictive regression modelling, the prevalence of any MCI diagnosis was 13.7% (95% CI 9.1-30.2) in the population of 60- to 64-year-olds. The estimated prevalence rates for specific diagnoses were: MCI 3.7%, ageing-associated cognitive decline 3.1%, Clinical Dementia Rating score (0.5) 2.8%, age-associated memory impairment 1%, other cognitive disorders 0.9%, and mild neurocognitive disorder 0.6%. Agreement on 'caseness' between various proposed diagnoses was at best fair and generally poor. Memory and other cognitive problems not meeting the threshold for dementia are relatively common in 60- to 64-year-old individuals living in the community. The prevalence rate varies up to six-fold according to the diagnostic criteria applied, with limited overlap between diagnoses. There is an urgent need for standardization of the criteria.
authors.affiliation: Department of Psychological Medicine, The Canberra Hospital, Canberra, Australia. Rajeev.Kumar@act.gov.au
authors.forename: Rajeev
authors.initials: R
authors.lastname: Kumar
authors.forename: Keith B G
authors.initials: KB
authors.lastname: Dear
authors.forename: Helen
authors.initials: H
authors.lastname: Christensen
authors.forename: Suse
authors.initials: S
authors.lastname: Ilschner
authors.forename: Anthony F
authors.initials: AF
authors.lastname: Jorm
authors.forename: Chantal
authors.initials: C
authors.lastname: Meslin
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Rosenman
authors.forename: Perminder S
authors.initials: PS
authors.lastname: Sachdev
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D000647:Amnesia / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D003430:Cross-Sectional Studies; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006304:Health Status; D006801:Humans; D015994:Incidence; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D009517:New South Wales; D010552:Personality Assessment / Q000706:statistics & numerical data*; D012016:Reference Values