title: [The absorption kinetics of silymarin microemulsion in rat intestine].
abstract: OBJECTIVE
  To survey the morphology and size distribution of silymarin microemulsion, to investigate the absorption of silymarin microemulsion in rat intestine compared with the absorption of silymarin micelle in rat Jejunum.
  
  
  METHODS
  The intestine in rats was canulated for in situ recirculation.
  
  
  RESULTS
  The absorption rate constants (Ka) of silymarin microemulsion at the entire intestine, ileum jejunum, duodenum and colon were 6.22 x 10(-2), 2.27 x 10(-2), 1.9 x 10(-2), 1.9 x 10(-2), 1.05 x 10(-2) and 0.43 x 10(-2) h(-1), respectively. The absorption rate constants of two kinds of silymarin micelle at jejunum were 0.36 x 10(-2), 0.65 x 10(-2) h(-1).
  
  
  CONCLUSIONS
  Silymarin microemulsion was well absorbed at the middle and lower segments of intestine in rats. The absorption was a first-order process with the passive diffusion mechanism.
authors.affiliation: Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China. yanliu@bjmu.edu.cn
authors.forename: Quan
authors.initials: Q
authors.lastname: Yuan
authors.forename: Xin-ru
authors.initials: XR
authors.lastname: Li
authors.forename: Hui-juan
authors.initials: HJ
authors.lastname: Wang
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D003106:Colon / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism; D004655:Emulsions; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D008823:Micelles; D010316:Particle Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D012838:Silymarin / Q000493:pharmacokinetics*
chemical_list: D004655:Emulsions; D008823:Micelles; D012838:Silymarin