Beta-lactamase gene expression in a penicillin-resistant Bacillus anthracis strain.
Expression of the bla1 and bla2 genes in an archetypal Bacillus anthracis strain is insufficient for penicillin resistance. In a penicillin-resistant clinical isolate, both genes are highly transcribed, but bla1 is the major contributor to high-level resistance to ampicillin. Differential expression of the bla genes is dependent upon strain background.
Chen
Yahua
Y
Department of Microbiology and Molecular Genetics, University of Texas--Houston Medical School, Houston, Texas 77030, USA.
Tenover
Fred C
FC
Koehler
Theresa M
TM
D001408:Bacillus anthracis / Q000187:drug effects* / Q000235:genetics*; D017931:DNA Primers; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics*; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D010403:Penicillin Resistance / Q000235:genetics*; D010957:Plasmids / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012988:Soil Microbiology; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics*
D017931:DNA Primers; D012336:RNA, Ribosomal, 16S; D001618:beta-Lactamases