title: [Association between the expression of estrogen receptor subunit in endometrial carcinoma and the prognostic factors of endometrial carcinoma].
abstract: OBJECTIVE
  To study the relationship between the expression of ERalpha and ERbeta mRNA in the fresh tissue from patients with endometrial carcinoma and to evaluate the association between the ratio of ERalpha/ERbeta and the prognostic factors of endometrial carcinoma.
  
  
  METHODS
  Multiplex RT-PCR was used to study the expression of ERalpha and ERbeta mRNA in the fresh endometrial tissue from 41 cases of endometrial carcinoma. The association between the expression of ERalpha/ERbeta mRNA and the prognostic factors of endometrial carcinoma was evaluated.
  
  
  RESULTS
  ERalpha mRNA and ERbeta mRNA were detected in 95% and 90.2% of the 41 cases of endometrial carcinoma, respectively. ERalpha/ERbeta > 1 was detected in 21 cases and ERalpha/ERbeta < 1 was detected in 14 cases. Analysis revealed an association between the ratio of ERalpha/ERbeta mRNA and the prognostic factors of endometrial carcinoma.
  
  
  CONCLUSIONS
  In this study, ERalpha mRNA overexpression (ERalpha/ERbeta > 1) was found associated with good prognostic factors of endometrial carcinoma, whereas ERbeta mRNA overexpression (ERalpha/ERbeta < 1) was found associated with poor prognostic factors of endometrial carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Jia-wen
authors.initials: JW
authors.lastname: Zhang
authors.forename: Zhi-lan
authors.initials: ZL
authors.lastname: Peng
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000235:genetics; D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000235:genetics; D004717:Endometrium / Q000737:chemistry; D047628:Estrogen Receptor alpha / Q000032:analysis* / Q000235:genetics; D047629:Estrogen Receptor beta / Q000032:analysis* / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D012333:RNA, Messenger