MS and NMR investigation of bioactive quinazolones.
To prepare effective PARP [poly(ADP)-ribose)polymerase-1] inhibitors, starting from 2-mercapto-4(3H)-quinazolone (1), several S-alkyl derivatives--2-alkylsulfanyl-3H-quinazolin-4-ones (2-5, 7-9)--as well as an S-benzyl derivative (10) were prepared using a simple alkylation method. Some of them are known compounds. Their structure was studied thoroughly by MS and NMR methods.
Szabó
Zoltán
Z
Department of Biochemistry and Medical Chemistry, Faculty of Medicine, University of Pécs, PO Box 99, H-7601 Pécs, Hungary.
Osz
Erzsébet
E
Lóránd
Tamás
T
D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008968:Molecular Conformation; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011799:Quinazolines / Q000032:analysis* / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011799:Quinazolines