Paraoxonase-1 gene Leu-Met55 and Gln-Arg192 polymorphisms are not associated with carotid artery atherosclerosis in a population-based cohort.
BACKGROUND
Paraoxonase-1 (PON1) is an enzyme that prevents low-density lipoprotein (LDL) oxidation. The role of polymorphisms of PON1 determining early atherosclerotic changes is currently unclear.


METHODS
Cross sectional cohort study.


METHODS
Nine hundred and ninety-nine subjects from a population-based cohort were screened. Intima-media thickness (IMT) was measured by ultrasonography. Leu-Met55 and Gln-Arg192 polymorphism were determined.


RESULTS
No association between PON1 genotypes and IMT was found. This finding remained after adjusting for confounding factors.


CONCLUSIONS
The PON1 Leu-Met55 and Gln-Arg192 polymorphisms are not major risk factors for atherosclerosis in the general Caucasian population.
Karvonen
Jarkko
J
Department of Internal Medicine, University of Oulu, Finland. jakarvon@paju.oulu.fi
Kauma
Heikki
H
Päivänsalo
Markku
M
Kesäniemi
Y Antero
YA
D001120:Arginine / Q000235:genetics; D001161:Arteriosclerosis / Q000235:genetics* / Q000473:pathology; D043303:Aryldialkylphosphatase / Q000235:genetics*; D017536:Carotid Artery, Common / Q000473:pathology*; D016022:Case-Control Studies; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004151:Dipeptides / Q000235:genetics; D005387:Finland; D005787:Gene Frequency; D005838:Genotype; D005973:Glutamine / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012042:Registries; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D044465:White People / Q000235:genetics
D004151:Dipeptides; D005973:Glutamine; C062625:leucylmethionine; D001120:Arginine; D043303:Aryldialkylphosphatase