title: Expanding the Hoogsteen edge of 2'-deoxyguanosine: consequences for G-quadruplex formation.
abstract: [structure: see text] The synthesis and self-assembling properties of 8-aryl-2'-deoxyguanosine derivatives are described. Our studies suggest that a properly placed acetyl group can increase the stability and specificity of the resulting G-quadruplex supramolecules by enhancing noncovalent interactions such as hydrogen bonds and pi-stacking.
authors.affiliation: Department of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, Puerto Rico 00931.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Gubala
authors.forename: José E
authors.initials: JE
authors.lastname: Betancourt
authors.forename: José M
authors.initials: JM
authors.lastname: Rivera
mesh_terms: D003849:Deoxyguanosine / Q000138:chemical synthesis* / Q000737:chemistry; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D012996:Solutions; D013696:Temperature
chemical_list: D012996:Solutions; D003849:Deoxyguanosine