title: [Pathogenesis of secondary hyperparathyroidism and renal bone disease].
abstract: Patients with chronic renal disease (CKD)almost always develop secondary hyperparathyroidism (SHPT) due to hypocalcemia, phosphate retention, and abnormalities in vitamin D (VD) metabolism. Concomitant decreases in VD receptor and calcium sensing receptor in the parathyroid glands render them more resistant to the action of VD and calcium, and accelerate parathyroid cell growth. Several types of bone diseases are known to occur in CKD patients. Excessive secretion of parathyroid hormone (PTH) due to SHPT causes high-turnover bone disease, called osteitis fibrosa. Among low-turnover bone disease (LTBD), osteomalacia which is characterized by calcification defect is often complicated with VD deficiency and/or aluminum accumulation. Recently, frequency of adynamic bone disease caused by PTH suppression, another type of LTBD, is increasing probably due to calcium salts as phosphate binder with or without VD treatment.
authors.affiliation: Department of Internal Medicine, Showa University, Northern Yokohama Hospital.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ito
authors.forename: Eriko
authors.initials: E
authors.lastname: Kinugasa
mesh_terms: D000535:Aluminum / Q000378:metabolism; D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology*; D002908:Chronic Disease; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology*; D006996:Hypocalcemia / Q000209:etiology; D007674:Kidney Diseases / Q000150:complications*; D010280:Parathyroid Glands / Q000166:cytology / Q000378:metabolism; D010281:Parathyroid Hormone / Q000502:physiology; D010758:Phosphorus / Q000378:metabolism; D017410:Practice Guidelines as Topic; D018167:Receptors, Calcitriol / Q000378:metabolism; D044169:Receptors, Calcium-Sensing / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000209:etiology
chemical_list: D010281:Parathyroid Hormone; D018167:Receptors, Calcitriol; D044169:Receptors, Calcium-Sensing; D010758:Phosphorus; D000535:Aluminum