title: Angiotensin-converting enzyme insertion-deletion polymorphism in primary open-angle glaucoma.
abstract: OBJECTIVE
  To investigate the hypothesis that primary open-angle glaucoma (POAG) is associated with a common insertion-deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene.
  
  
  METHODS
  ACE I/D polymorphism was investigated in a control group of healthy subjects (n = 101) and in a group of patients diagnosed with POAG (n = 104). Polymerase chain reaction detection of I/D polymorphism was used to determine the presence of the two ACE alleles in the groups.
  
  
  RESULTS
  Neither the I/D genotype distributions nor the allele frequencies differed significantly between POAG and control subjects (DD genotype 34.6 vs. 39.6%; ID genotype 53.9 vs. 40.6%; II genotype 11.5 vs. 19.8%, p = 0.1; D allele 61.5 vs. 60%; I allele 38.5 vs. 40%, p = 0.8).
  
  
  CONCLUSIONS
  We could not identify a possible association of the I/D polymorphism in the ACE gene with POAG, however further studies with larger patient numbers in different populations are required to clarify the role of ACE gene in susceptibility to POAG.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. aozkur@hotmail.com
authors.forename: Mehtap
authors.initials: M
authors.lastname: Ozkur
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Erbagci
authors.forename: Kivanc
authors.initials: K
authors.lastname: Gungor
authors.forename: Muradiye
authors.initials: M
authors.lastname: Nacak
authors.forename: Sukru
authors.initials: S
authors.lastname: Aynacioglu
authors.forename: Necdet A
authors.initials: NA
authors.lastname: Bekir
mesh_terms: D005260:Female; D017353:Gene Deletion; D005902:Glaucoma, Open-Angle / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A