title: Evaluation of the role of constitutive isocitrate lyase activity in Yersinia pestis infection of the flea vector and mammalian host.
abstract: Yersinia pestis, unlike the closely related Yersinia pseudotuberculosis, constitutively produces isocitrate lyase (ICL). Here we show that the Y. pestis aceA homologue encodes ICL and is required for growth on acetate but not for flea infection or virulence in mice. Thus, deregulation of the glyoxylate pathway does not underlie the recent adaptation of Y. pestis to arthropod-borne transmission.
authors.affiliation: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases/NIH, 903 S. 4th St., Hamilton, MT 59840, USA.
authors.forename: Florent
authors.initials: F
authors.lastname: Sebbane
authors.forename: Clayton O
authors.initials: CO
authors.lastname: Jarrett
authors.forename: Jan R
authors.initials: JR
authors.lastname: Linkenhoker
authors.forename: B Joseph
authors.initials: BJ
authors.lastname: Hinnebusch
mesh_terms: D000818:Animals; D007303:Insect Vectors / Q000382:microbiology*; D007522:Isocitrate Lyase / Q000502:physiology*; D051379:Mice; D005423:Siphonaptera / Q000382:microbiology*; D014774:Virulence; D015010:Yersinia pestis / Q000201:enzymology* / Q000472:pathogenicity*; D015011:Yersinia pseudotuberculosis / Q000472:pathogenicity
chemical_list: D007522:Isocitrate Lyase