Circulation of type 1 vaccine-derived poliovirus in the Philippines in 2001.
In 2001, highly evolved type 1 circulating vaccine-derived poliovirus (cVDPV) was isolated from three acute flaccid paralysis patients and one contact from three separate communities in the Philippines. Complete genomic sequencing of these four cVDPV isolates revealed that the capsid region was derived from the Sabin 1 vaccine strain but most of the noncapsid region was derived from an unidentified enterovirus unrelated to the oral poliovirus vaccine (OPV) strains. The sequences of the cVDPV isolates were closely related to each other, and the isolates had a common recombination site. Most of the genetic and biological properties of the cVDPV isolates were indistinguishable from those of wild polioviruses. However, the most recently identified cVDPV isolate from a healthy contact retained the temperature sensitivity and partial attenuation phenotypes. The sequence relationships among the isolates and Sabin 1 suggested that cVDPV originated from an OPV dose given in 1998 to 1999 and that cVDPV circulated along a narrow chain of transmission. Type 1 cVDPV was last detected in the Philippines in September 2001, and population immunity to polio was raised by extensive OPV campaigns in late 2001 and early 2002.
Shimizu
Hiroyuki
H
Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan. hshimizu@nih.go.jp.
Thorley
Bruce
B
Paladin
Fem Julia
FJ
Brussen
Kerri Anne
KA
Stambos
Vicki
V
Yuen
Lilly
L
Utama
Andi
A
Tano
Yoshio
Y
Arita
Minetaro
M
Yoshida
Hiromu
H
Yoneyama
Tetsuo
T
Benegas
Agnes
A
Roesel
Sigrun
S
Pallansch
Mark
M
Kew
Olen
O
Miyamura
Tatsuo
T
D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D004770:Enterovirus / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008969:Molecular Sequence Data; D010679:Philippines / Q000453:epidemiology; D010802:Phylogeny; D011051:Poliomyelitis / Q000453:epidemiology* / Q000821:virology*; D017955:Poliovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D011055:Poliovirus Vaccine, Oral; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA
D011055:Poliovirus Vaccine, Oral