The effects of total-body irradiation on the survival and skin wound healing of rats with combined radiation-wound injury.
To investigate the effects of total body irradiation on the healing of skin wounds, rats were irradiated with a (60)Co gamma-ray source, in which single doses ranged from 1 to 8 Gy. After irradiation, two whole-thickness circular skin wounds, 22 mm in diameter and covering 2.5% of the total body surface area, were made immediately on the back of each animal. The average healing time for the simple wound was 18.3 +/- 2.1 days, whereas when the wound was combined with 1, 2, 3, 4, 5, and 6 Gy of radiation, the average wound healing time was delayed by 0.3, 0.8, 1.1, 3.5, 6.2, and 9.5 days, respectively. The average healing time was significantly decreased with irradiation doses exceeding 4 Gy, as compared with the healing time for the simple wound without irradiation (p < 0.05). The statistical results showed that the percentage of the unclosed wound with the increased doses in combined radiation injury was significantly proportional to the recovery time kinetics.
Ran
Xinze
X
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injuries, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China. Ranxize@yahoo.com
Cheng
Tianmin
T
Shi
Chunmeng
C
Xu
Hui
H
Qu
Jifu
J
Yan
Guohe
G
Su
Yongping
Y
Wang
Wenchang
W
Xu
Rufu
R
D000818:Animals; D003037:Cobalt Radioisotopes / Q000008:administration & dosage / Q000097:blood; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000401:mortality; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries / Q000528:radiation effects*; D015996:Survival Rate; D014916:Whole-Body Irradiation / Q000009:adverse effects* / Q000401:mortality; D014945:Wound Healing / Q000528:radiation effects*
D003037:Cobalt Radioisotopes