Pemphigus foliaceus with neutrophilic spongiosis evolving to an atypical pemphigus phenotype.
A 46-year-old Brazilian man, with initial pustular lesions, neutrophilic spongiosis and subcorneal cleavage evolved to an atypical pemphigus phenotype, with suprabasal acantholysis. Interestingly, his autoantibody profile, tested by immunofluorescence, immunoblotting, enzyme-linked immunosorbent assay, and immunoprecipitation revealed exclusive IgG anti-desmoglein 1 antibodies in all phases of the disease.
Gabbi
Tatiana Villas Boas
TV
Department of Dermatology, University of São Paulo, São Paulo, Brazil.
Bernardelli
Isabela M
IM
Santi
Cláudia G
CG
Maruta
Celina W
CW
Kodani
Vanessa
V
Sotto
Mirian N
MN
Li
Ning
N
Hilario-Vargas
Julio
J
Diaz
Luis A
LA
Rivitti
Evandro A
EA
Aoki
Valéria
V
D000051:Acantholysis; D001323:Autoantibodies / Q000032:analysis; D015820:Cadherins / Q000276:immunology; D051183:Desmoglein 1; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D004817:Epidermis / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D020556:Neutrophil Infiltration; D010392:Pemphigus / Q000276:immunology*; D010641:Phenotype; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology*
D001323:Autoantibodies; D015820:Cadherins; D051183:Desmoglein 1; D007074:Immunoglobulin G