Highly diastereoselective and enantioselective synthesis of enantiopure C2-Symmetrical vicinal diamines by reductive homocoupling of chiral N-tert-butanesulfinyl imines.
[reaction: see text] An efficient and straightforward method for the preparation of highly enantiomerically enriched C2-symmetrical vicinal diamines by the reductive homocoupling of aromatic N-tert-butanesulfinyl imines in the presence of SmI2 and HMPA was developed. It gives access to a variety of enantiopure C2-symmetrical 1,2-diamines in a very mild and practical way.
Zhong
Yu-Wu
YW
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
Izumi
Kenji
K
Xu
Ming-Hua
MH
Lin
Guo-Qiang
GQ