In vivo detection of microglial activation in frontotemporal dementia.
Using positron emission tomography and [(11)C](R)-PK11195, a marker of "peripheral benzodiazepine sites" that is upregulated on activated microglia during progressive tissue pathology, we show increased binding of [(11)C](R)-PK11195 in frontotemporal lobar degeneration in the typically affected frontotemporal brain regions. This implies the presence of an active glial response reflecting progressive neuronal degeneration. It also suggests that increased [(11)C](R)-PK11195 binding, previously demonstrated for Alzheimer's disease, may occur independently from increased amyloid plaque formation, given that it is not a characteristic feature of frontotemporal lobar degeneration.
Cagnin
Annachiara
A
MRC Cyclotron Unit, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom.
Rossor
Martin
M
Sampson
Elizabeth L
EL
Mackinnon
Toby
T
Banati
Richard B
RB
D000368:Aged; D016009:Chi-Square Distribution; D003704:Dementia / Q000378:metabolism* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism; D017628:Microglia / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D011485:Protein Binding
D007546:Isoquinolines; C037850:PK 11195