Cytoplasmic membrane iron permease systems in the bacterial cell envelope.
Iron is a vital nutrient for the vast majority of organisms. Gram-positive bacteria, Gram-negative bacteria and archaea established different strategies to utilize iron from various sources. This article concentrates on the cytoplasmic membrane-associated uptake systems involved in the acquisition of iron. Genetic, biochemical and structural data as well as computational analyses were taken into consideration. Besides divalent metal transporters of the Nramp type and ferrous iron transport proteins of the Feo type, four distinct families of ABC transporters related to iron uptake are known. Their components mediate the transfer of iron, siderophores, heme and vitamin B12 into the cytosol of prokaryotes.
Koster
Wolfgang
W
Environmental Microbiology and Molecular Ecotoxicology (MIX), Swiss Federal Inst. for Environmental Science and Technology (EAWAG), Uberlandstrasse 133, CH-8600 Dubendorf, Switzerland. wlk498@mail.usask.ca <wlk498@mail.usask.ca>
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000378:metabolism; D006418:Heme / Q000737:chemistry; D007501:Iron / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics; D026901:Membrane Transport Proteins / Q000737:chemistry*; D008954:Models, Biological; D009161:Mycobacterium / Q000378:metabolism; D011485:Protein Binding; D014805:Vitamin B 12 / Q000378:metabolism
D018528:ATP-Binding Cassette Transporters; D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; D006418:Heme; D000255:Adenosine Triphosphate; D007501:Iron; D014805:Vitamin B 12