title: [Toxicological characterization of calcium ketopantoylaminobutyrate].
abstract: The investigation of toxicity of calcium ketopantoylaminobutyrate (Ca-KPAB) showed that this newly synthesized compound belongs to the class of low-toxicity substances. The LD 50 of Ca-KPAB for oral administration is lower than that of pantogam. No toxicity manifestations and local irritant activity was observed upon chronic administration of Ca-KPAB. The therapeutic index of Ca-KPAB is more than 17 times that of pantogam.
authors.forename: A L
authors.initials: AL
authors.lastname: Karaev
authors.forename: G S
authors.initials: GS
authors.lastname: Kozlova
authors.forename: T N
authors.initials: TN
authors.lastname: Smirnova
authors.forename: V I
authors.initials: VI
authors.lastname: Gunar
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000633:toxicity
chemical_list: C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid