Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines.
Cycloaddition of C-imidazolyl-N-phenylnitrones with monosubstituted alkenes afforded 5-imidazolyl substituted isoxazolidines with high regioselectivity. Novel isoxazolidines were screened for their antibacterial activities against S. aureus, E. coli and B. subtilis by using streptomycin as a positive control. They were also tested for their antifungal activities against F. moniliforme, A. niger and C. acremonium by using nystatin as a positive control. Isoxazolidines, 4a and 4f exhibited more potent inhibition towards antifungal activity than the other isoxazolidines prepared.
Sadashiva
M P
MP
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, India.
Mallesha
H
H
Hitesh
N A
NA
Rangappa
K S
KS
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007555:Isoxazoles / Q000138:chemical synthesis / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000187:drug effects; D010080:Oxazoles / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007555:Isoxazoles; D010080:Oxazoles; C064210:oxazolidine