title: Retinal thickness in normal and RCD1 dogs using optical coherence tomography.
abstract: OBJECTIVE
  To compare retinal thickness and retinal nerve fiber layer (RNFL) thickness values obtained by optical coherence tomography (OCT) in normal dogs and dogs with rod-cone dysplasia type 1 (RCD1).
  
  
  METHODS
  Eight eyes of 6 normal hound-bred dogs and 12 eyes of 6 dogs with RCD1, 2 to 5 years of age, were examined using the Fast RNFL Thickness, Fast Macular Thickness, and line scan protocols of OCT.
  
  
  RESULTS
  Retinal thickness was significantly higher in the tapetal fundus than in the non-tapetal fundus, in both normal (P = .0036) and RCD1 (P < .0001) dogs. Superotemporal, superonasal, and inferior retinal thickness values were significantly higher in normal dogs (P < .0001). Area centralis thickness was 183.5 +/- 10.66 microm in normal dogs and 136.16 +/- 13.12 microm in RCD1 dogs (P < .0001). There was no difference in RNFL thickness between normal and RCD1 dogs (P > .05).
  
  
  CONCLUSIONS
  OCT scanning in dogs is considered to be a useful method of evaluation in future retinal studies in this animal model.
authors.affiliation: Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Carla Q
authors.initials: CQ
authors.lastname: Panzan
authors.forename: Dilek
authors.initials: D
authors.lastname: Güven
authors.forename: James D
authors.initials: JD
authors.lastname: Weiland
authors.forename: Rohit R
authors.initials: RR
authors.lastname: Lakhanpal
authors.forename: Michael
authors.initials: M
authors.lastname: Javaheri
authors.forename: Eugene
authors.initials: E
authors.lastname: de Juan
authors.forename: Mark S
authors.initials: MS
authors.lastname: Humayun
mesh_terms: D000818:Animals; D003941:Diagnostic Techniques, Ophthalmological / Q000662:veterinary; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs; D009412:Nerve Fibers / Q000473:pathology; D012160:Retina / Q000473:pathology*; D012162:Retinal Degeneration / Q000175:diagnosis / Q000662:veterinary*; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000662:veterinary*; D014741:Video Recording