Autoimmune hepatitis--sequel of a relapsing hepatitis A in a 75-year-old woman.
Acute hepatitis A virus (HAV) infection is a global cause of acute hepatitis. However, chronic HAV infection is unlikely. Nevertheless, there is some evidence that acute infection with HAV may trigger chronic active hepatitis which fulfils the criteria of autoimmune hepatitis (AIH). Whether AIH following HAV infection is virus specific remains unclear. Despite evidence that inherited factors may play a role in the development of autoimmunity after viral infection, the pathomechanism remains unclear. We describe a 75-year-old woman with a history of pulmonary sarcoidosis who developed AIH after acute HAV infection.
Grünhage
F
F
Department of Internal Medicine I, University of Bonn, Bonn, Germany. frank.gruenhage@ukb.uni.bonn.de
Spengler
U
U
Fischer
H P
HP
Sauerbruch
T
T
D000208:Acute Disease; D000368:Aged; D005260:Female; D006506:Hepatitis A / Q000150:complications* / Q000276:immunology; D019693:Hepatitis, Autoimmune / Q000209:etiology* / Q000276:immunology / Q000821:virology; D006801:Humans; D017565:Sarcoidosis, Pulmonary / Q000150:complications