title: Effects of different brands of fluoride dentifrices on dental caries incidence in the rat.
abstract: The effectiveness of 3 different brands of fluoride-containing dentifrices on the prevention of dental caries was investigated in molars of young rats. Forty albino Wistar rats weighing 50-80g, 28 males and 12 females were inoculated in the mouth with streptococcus viridans daily from day 1 to day 5 of the experiment. The animals were then divided into four groups and fed with rat pellets containing 60% sucrose added as granulated sugar. All the groups were given water ad libitum. Group I had daily tooth brushing with water and served as the control while groups II, III and IV received daily brushing of their molar teeth with different fluoride--containing dentifrices: (Maxam, Florish and Close-Up respectively. All topical treatments were given for one minute daily per rat from day 6 to day 56 of the experiment. At the end of the experiment the animals were sacrificed, the jaws removed and the teeth were scored for occlusal caries. All fluoride--containing dentifrices tested reduced caries in the following order: Maxam 37.86%, Florish 59.22% and Close-Up 57.28%. This study confirmed that fluoride incorporated in Florish and Close-Up showed significant levels of caries reduction (P <0.01) and (P <0.05) respectively in the rat. It also adds credence to Dental Health Education in the application of various tooth pastes in oral hygiene measures.
authors.affiliation: Departments of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: O O
authors.initials: OO
authors.lastname: Akande
authors.forename: A R A
authors.initials: AR
authors.lastname: Alada
authors.forename: G A
authors.initials: GA
authors.lastname: Aderinokun
authors.forename: F A
authors.initials: FA
authors.lastname: Odigwe
mesh_terms: D000818:Animals; D002327:Cariostatic Agents / Q000494:pharmacology*; D003731:Dental Caries / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D005460:Fluorides, Topical / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014100:Toothpastes / Q000494:pharmacology*
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D014100:Toothpastes