[Protective effect of the intraperitoneal and intragastric administration of PGP-peptide on ethanol-induced erosions and acetate-induced ulcers in rats].
We investigated the impact of PGP on ethanol-induced mucosal damages and on the development of acetate gastric ulcers in rats for two ways of introduction--intraperitoneal and intragastric. PGP in the dozes of 0.1, 1 and 10 mg/kg authentically reduced the area of ethanol-induced mucosal damages at intraperitoneal introduction by 43, 70 and 65%, respectively; at intragastric introduction--by 64, 66 and 83%, respectively. Intraperitoneal introduction of PGP in the doze of 1 mg/kg and its intragastric introduction in the doze of 0.1 mg/kg equally reduced the development of acetate gastric ulcers by 73%. Thus, irrespective of the way of its introduction (intraperitoneal or intragastric) and its doze, PGP has a significant protective anti-ulcerous effect and reduces the development of acetate gastric ulcers in rats.
Bakaeva
Z V
ZV
Badmaeva
K E
KE
Zheliaznik
N Ia
NIa
Samonina
G E
GE
D019342:Acetic Acid / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D011392:Proline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D009842:Oligopeptides; D020011:Protective Agents; C113164:prolyl-glycyl-proline; D000431:Ethanol; D011392:Proline; D019342:Acetic Acid