title: Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression.
abstract: The mechanism that regulates the plasticity of bone marrow cells (BMCs) into hepatocytes is poorly understood. We developed a green fluorescent protein/carbon tetrachloride model to find that BMC transplantation recovered liver damage. Serum albumin level and liver fibrosis were recovered by BMC transplantation. To understand the mechanism, we used DNA-chip technology to profile the change of transient gene expression before and after BMC transplantation. On the basis of gene expression with self-organizing map using specific equation, genes were classified into 153 clusters. The information is useful to understand the dramatic gene activation during the process of the plasticity of BMC.
authors.affiliation: Department of Molecular Science and Applied Medicine (Gastroenterology and Hepatology), Yamaguchi University School of Medicine, Minami Kogushi 1-1-1, Ube, Yamaguchi 755 8505, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Omori
authors.forename: Shuji
authors.initials: S
authors.lastname: Terai
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Kouji
authors.initials: K
authors.lastname: Aoyama
authors.forename: Isao
authors.initials: I
authors.lastname: Sakaida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishina
authors.forename: Koh
authors.initials: K
authors.lastname: Shinoda
authors.forename: Shunji
authors.initials: S
authors.lastname: Uchimura
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hamamoto
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Okita
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology*; D016026:Bone Marrow Transplantation; D002251:Carbon Tetrachloride / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D005355:Fibrosis / Q000139:chemically induced / Q000628:therapy; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D022781:Hepatocytes / Q000166:cytology / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D005810:Multigene Family; D020411:Oligonucleotide Array Sequence Analysis; D015533:Transcriptional Activation
chemical_list: D049452:Green Fluorescent Proteins; D002251:Carbon Tetrachloride