title: Evaluation of the anti-genotoxicity of leaf extract of Ashwagandha.
abstract: We have undertaken the studies to investigate the presence of various activities of the leaf extract of Ashwagandha (Lash), a commonly used shrub in Indian traditional medicine, Ayurveda. In the present study, we studied the effect of Lash against MNNG-induced genotoxicity in onion root tip cells. We report that Lash offered substantial protection against the mutagenic effects of MNNG.
authors.affiliation: Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, India.
authors.forename: G
authors.initials: G
authors.lastname: Rani
authors.forename: K
authors.initials: K
authors.lastname: Kaur
authors.forename: R
authors.initials: R
authors.lastname: Wadhwa
authors.forename: S C
authors.initials: SC
authors.lastname: Kaul
authors.forename: A
authors.initials: A
authors.lastname: Nagpal
mesh_terms: D000490:Allium; D016587:Antimutagenic Agents / Q000494:pharmacology* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000187:drug effects*; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity; D019697:Onions / Q000166:cytology / Q000187:drug effects / Q000235:genetics; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000166:cytology / Q000187:drug effects; D010946:Plants, Medicinal; D032341:Withania / Q000737:chemistry*
chemical_list: D016587:Antimutagenic Agents; D009153:Mutagens; D010936:Plant Extracts; D008769:Methylnitronitrosoguanidine; C030693:Ashwagandha