Circulating IGF-1 and its role in cancer: lessons from the IGF-1 gene deletion (LID) mouse.
Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. Our studies have focused on mouse models where circulating IGF-1 levels are reduced, while tissue expression of IGF-1 is normal. These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth.
Yakar
Shoshana
S
Diabetes Branch, Room 8D12, Building 10, National Institutes of Health, MSC 1758, Bethesda MD 20892-1758, USA.
Pennisi
Patricia
P
Zhao
Hong
H
Zhang
Yang
Y
LeRoith
Derek
D
D000818:Animals; D017353:Gene Deletion; D007334:Insulin-Like Growth Factor I / Q000235:genetics* / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000378:metabolism*
D007334:Insulin-Like Growth Factor I