title: Determinants of immune reconstitution inflammatory syndrome in HIV type 1-infected patients with tuberculosis after initiation of antiretroviral therapy.
abstract: Immune reconstitution inflammatory syndrome (IRIS) occurred in 16 of 37 antiretroviral-naive patients who were treated subsequently for tuberculosis and human immunodeficiency virus (HIV) type 1 infection. IRIS was related to increases in the CD4 cell percentage and in the ratio of CD4 cells to CD8 cells after 1 month of antiretroviral therapy and to dissemination of tuberculosis. These results have implications for the diagnosis of IRIS and the understanding of its pathogenesis.
authors.affiliation: Department of Infectious and Tropical Diseases, INSERM E0357, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. guillaume.breton@bch.ap-hop-paris.fr
authors.forename: Guillaume
authors.initials: G
authors.lastname: Breton
authors.forename: Xavier
authors.initials: X
authors.lastname: Duval
authors.forename: Candice
authors.initials: C
authors.lastname: Estellat
authors.forename: Xavier
authors.initials: X
authors.lastname: Poaletti
authors.forename: Daniel
authors.initials: D
authors.lastname: Bonnet
authors.forename: David
authors.initials: D
authors.lastname: Mvondo Mvondo
authors.forename: Pascale
authors.initials: P
authors.lastname: Longuet
authors.forename: Catherine
authors.initials: C
authors.lastname: Leport
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Vildé
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013577:Syndrome; D014376:Tuberculosis / Q000150:complications / Q000276:immunology*
chemical_list: D044966:Anti-Retroviral Agents