Central pain and complex motoric symptoms after gosarelin therapy of prostate cancer.
A 76-year-old man with prostate cancer T3N0M0 and increasing PSA was treated with goserelin three times in a half year. As soon as the first treatment, he described subjective muscle weakness. After the third treatment, he developed complex motoric symptoms and atypical central pain with a likely association to goserelin. His left arm had signs of spastic movement; pain deteriorated after relaxation. The right hand showed muscle cramps under passive movements of the left arm that were not typical for rigor. He felt aching and partial burning pain in his whole body. There were few allodynic areas, mainly in the left arm. Several treatment approaches failed and the patient died some weeks after the first contact with our pain clinic due to pneumonia.
Ernst
G
G
Blefjell sykehus Kongsberg, Anestesi, Drammensvei 4, 3612 Kongsberg. gernot.ernst@blefjellsykehus.no < gernot.ernst@blefjellsykehus.no>
Gericke
A
A
Berg
P
P
D000368:Aged; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D017809:Fatal Outcome; D017273:Goserelin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D018908:Muscle Weakness / Q000139:chemically induced*; D010146:Pain / Q000139:chemically induced*; D011471:Prostatic Neoplasms / Q000188:drug therapy*
D017273:Goserelin