title: [Neurogenesis in the mature olfactory bulb and it's possible functional destination].
abstract: This review is concerned with neurogenesis in the mature mammalian brain with emphasis on cell population renewal in the olfactory bulb (OB). The structural and functional features of the OB are considered along with data on neurotropic viruses and toxic dust penetration into the CNS through the OB. We hypothesize a protective role of neurogenesis in the mature OB. This suggests that normal renewal of cell populations in the OB is an important barrier mechanism protecting the brain from invasion of small amounts of harmful neurotropic agents (ex. viruses and particles of toxic dust), which can cause various neurodegenerative diseases.
authors.forename: E V
authors.initials: EV
authors.lastname: Loseva
authors.forename: S V
authors.initials: SV
authors.lastname: Karnup
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019610:Cytoprotection; D004391:Dust; D006801:Humans; D008670:Metals; D009297:Nasal Mucosa / Q000503:physiopathology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009830:Olfactory Bulb / Q000166:cytology / Q000502:physiology* / Q000821:virology; D009833:Olfactory Pathways / Q000503:physiopathology; D014777:Virus Diseases / Q000503:physiopathology; D014780:Viruses
chemical_list: D004391:Dust; D008670:Metals