title: [Comparative genomic hybridization of esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in high-incidence region of esophageal carcinoma, Linzhou Henan].
abstract: OBJECTIVE
  To characterize the profiles of chromosome imbalance in esophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA) from the high incidence area in Henan.
  
  
  METHODS
  Chromosomal aberrations of 37 samples of SCC and 30 GCA were analyzed by comparative genomic hybridization comparative genomic hybridization (CGH).
  
  
  RESULTS
  It was found that the most frequently detected gains were on chromosome arm 8q (78%), and followed by 3q, 5p, 6q and 7p. The most frequent loss was found on 3p (57%), and followed by 8p, 9q and 11q in SCC. For GCA, the most frequent gain was found on chromosome arm 20q (43%), and followed by 6q, 8q and 6p. The most frequent loss was on the chromosome 17p (57%), and followed by 19p, 1p and 4p.
  
  
  CONCLUSIONS
  The present findings demonstrate that gains of 8q, 3q and 5p, and losses of 3p, 8p, and 9q are characteristic profile of chromosome imbalance in SCC, and the gains of 20q, 6q and losses of 17p, 19p and 1p are characteristic profile of chromosome imbalance in GCA, which provide important theoretic information for identifying and cloning novel SCC/GCA-related genes.
authors.affiliation: Laboratory for Cancer Research, College of Medicine, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, 450052 P. R. China.
authors.forename: Yan-ru
authors.initials: YR
authors.lastname: Qin
authors.forename: Li-dong
authors.initials: LD
authors.lastname: Wang
authors.forename: Dora
authors.initials: D
authors.lastname: Kwong
authors.forename: Xin-yuan
authors.initials: XY
authors.lastname: Guan
authors.forename: Ze-hao
authors.initials: ZH
authors.lastname: Zhuang
authors.forename: Zong-min
authors.initials: ZM
authors.lastname: Fan
authors.forename: Ji-ye
authors.initials: JY
authors.lastname: An
authors.forename: George
authors.initials: G
authors.lastname: Tsao
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics; D002299:Cardia; D002886:Chromosomes, Human, Pair 17; D002890:Chromosomes, Human, Pair 20; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D004273:DNA, Neoplasm / Q000235:genetics; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005784:Gene Amplification; D017353:Gene Deletion; D006801:Humans; D009693:Nucleic Acid Hybridization / Q000379:methods; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm