title: Biogenesis of the Gram-negative bacterial outer membrane.
abstract: Gram-negative bacteria are bounded by two membranes. The outer membrane consists of phospholipids, lipopolysaccharides, lipoproteins and integral outer membrane proteins, all of which are synthesized in the cytoplasm. Recently, much progress has been made in the elucidation of the mechanisms of transport of these molecules over the inner membrane, through the periplasm and into the outer membrane, in part by exploiting the extraordinary capacity of Neisseria meningitidis to survive without lipopolysaccharide.
authors.affiliation: Department of Molecular Microbiology and Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
authors.forename: Martine P
authors.initials: MP
authors.lastname: Bos
authors.forename: Jan
authors.initials: J
authors.lastname: Tommassen
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000378:metabolism; D009345:Neisseria meningitidis / Q000378:metabolism
chemical_list: D001425:Bacterial Outer Membrane Proteins; D008070:Lipopolysaccharides; C115176:Omp85 protein, Neisseria