title: [Report of 8 cases of bcr-abl gene positive thrombocytosis and review of the literature].
abstract: OBJECTIVE
  To analyse the features of 8 cases of Bcr(+) thrombocytosis.
  
  
  METHODS
  The clinical and hematological features and therapeutic outcomes were studied retrospectively in 8 Bcr(+) thrombocytosis and compared with essential thrombocytosis (ET) and chronic myeloid leukemia-chronic phase thrombocytosis (CML-CP-T). BCR-ABL fusion gene was detected with PCR.
  
  
  RESULTS
  (1) Except for the presence of BCR-ABL fusion gene, there was no significant difference in clinical and hematological features and therapeutic outcomes between thrombocytosis with or without BCR-ABL. (2) The Bcr(+) thrombocytosis differed from CML-CP-T in the following aspects: female predominance, milder or no splenomegaly, peripheral leukocytes count < 40 x 10(9)/L, less or no basophilia and fewer immature granulocytes in peripheral blood, bone marrow granulocytic and/or megakaryocytic lineage hyperplasia, normal or increased neutrophil alkaline phosphatase score and less blastic transformation.
  
  
  CONCLUSIONS
  Bcr(+) thrombocytosis may be considered as a new member of chronic myeloproliferative diseases, a variant of essential thrombocythemia.
authors.affiliation: Department of Hematology, Second Affiliated Hospital, Hebei Medical University, Shijiazhuang 050000, China.
authors.forename: Feng-ru
authors.initials: FR
authors.lastname: Lin
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D015466:Leukemia, Myeloid, Chronic-Phase / Q000235:genetics / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013922:Thrombocytosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D055815:Young Adult
chemical_list: D016044:Fusion Proteins, bcr-abl