Lipid raft-mediated entry is not required for Chlamydia trachomatis infection of cultured epithelial cells.
Using pharmacologic and biochemical criteria, we evaluated whether uptake of four different Chlamydia trachomatis serovars, D, E, K, and L2, was dependent upon lipid rafts. Our data suggest that lipid raft-mediated entry is not required for C. trachomatis infection of cultured epithelial cells.
Gabel
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Division of Infectious Disease, Box 0654, University of California-San Francisco, San Francisco, CA 94143-0654, USA.
Elwell
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van Ijzendoorn
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SC
Engel
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D051242:Caveolin 1; D022461:Caveolins / Q000032:analysis; D002692:Chlamydia trachomatis / Q000472:pathogenicity*; D002772:Cholera Toxin / Q000494:pharmacology; D005677:G(M1) Ganglioside / Q000032:analysis; D006367:HeLa Cells; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology*; D018272:Porins / Q000032:analysis; D047392:beta-Cyclodextrins / Q000494:pharmacology
D051242:Caveolin 1; D022461:Caveolins; D018272:Porins; D047392:beta-Cyclodextrins; C108732:methyl-beta-cyclodextrin; C071677:omp1 protein, Chlamydia trachomatis; D005677:G(M1) Ganglioside; D002772:Cholera Toxin