title: Interleukin-6 and tumor necrosis factor alpha as predictors of success after emergent cerclage.
abstract: Serum levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) were measured in patients requiring an emergent cerclage to determine if they are predictive of successful pregnancy outcome. Women with a clinical diagnosis of cervical incompetence requiring an emergent cerclage between 15 and 24 weeks gestation were enrolled. Asymptomatic women of the same gestational age range were recruited as controls. IL-6 and TNF-alpha levels were measured by enzyme-linked immunosorbent assay. Twenty-one women underwent emergent cerclage and participated in the study, 15 (71%) of whom delivered after 28 weeks. Twenty-one women served as controls. IL-6 levels were increased in women with cervical incompetence compared with control subjects, but there were no differences between cerclage success and failure groups. TNF-alpha was not increased in women with cervical incompetence and did not predict success of emergent cerclage. IL-6 levels were increased in women with cervical incompetence who required an emergent cerclage.
authors.affiliation: Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois 60612, USA.
authors.forename: Loraine K
authors.initials: LK
authors.lastname: Endres
authors.forename: Eileen Y
authors.initials: EY
authors.lastname: Wang
mesh_terms: D000328:Adult; D015415:Biomarkers; D016022:Case-Control Studies; D023802:Cerclage, Cervical; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D002581:Uterine Cervical Incompetence / Q000601:surgery*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha