Premenstrual asthma: emphasis on drug therapy options.
Premenstrual asthma is quite common, affecting up to 40% of women. Some studies suggest exacerbations of asthma requiring emergency department visits or hospitalizations are more common in the perimenstrual phase. Several drug treatment modalities for premenstrual asthma have been evaluated. Drug therapies that may be beneficial include leukotriene receptor antagonists, long acting inhaled beta2 agonists, progesterone, estradiol, and gonadotropin-releasing hormone (GnRH) analogs. Further double-blind, randomized, placebo-controlled studies are required before the optimal drug therapy for premenstrual asthma is established.
Redmond
Amy M
AM
UT Bowld Hospital, Memphis, Tennessee, USA.
James
Alan W
AW
Nolan
Shambria Haynie
SH
Self
Timothy H
TH
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D004636:Emergency Service, Hospital; D004638:Emergency Treatment / Q000379:methods; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006801:Humans; D020024:Leukotriene Antagonists / Q000008:administration & dosage; D008597:Menstrual Cycle / Q000502:physiology; D011293:Premenstrual Syndrome / Q000150:complications*; D011374:Progesterone / Q000008:administration & dosage*; D011379:Prognosis; D012129:Respiratory Function Tests; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D018927:Anti-Asthmatic Agents; D020024:Leukotriene Antagonists; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone