title: Complexation between PVP and Gantrez polymer and its effect on release and bioadhesive properties of the composite PVP/Gantrez films.
abstract: Complexation between poly(methyl vinyl ether-maleic anhydride) copolymer (Gantrez AN 169) and polyvinylpyrrolidone (PVP K-90D) in aqueous solutions were investigated using a viscometric method and Raman spectroscopy. The composite films with different weight ratios of PVP to Gantrez were prepared in the presence of N-methyl-2-pyrrolidone. The release profiles of diclofenac sodium (DS) from these films were determined and the bioadhesive properties measured. An interpolymer complex was formed through hydrogen bonding between the carbonyl groups of PVP and the hydroxyl groups of Gantrez. The formation of interpolymer hydrogen bonds reduced the interaction of the polymers with water molecules, thus resulting in a lower solubility of the complex in water and a further retarded release of DS from the composite films. The interpolymer complexation was also found to increase the bioadhesive properties of the composite films to a silicone elastomer substrate. The complexation of PVP and the Gantrez copolymer in the composite films was a critical factor affecting the release of DS from the films and the bioadhesive properties of the films.
authors.affiliation: Department of Pharmacy, National University of Singapore, Singapore.
authors.forename: Jin Song
authors.initials: JS
authors.lastname: Hao
authors.forename: Lai Wah
authors.initials: LW
authors.lastname: Chan
authors.forename: Ze Xiang
authors.initials: ZX
authors.lastname: Shen
authors.forename: Paul W S
authors.initials: PW
authors.lastname: Heng
mesh_terms: D000269:Adhesives / Q000737:chemistry / Q000493:pharmacokinetics*; D002626:Chemistry, Pharmaceutical; D004008:Diclofenac / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D006860:Hydrogen Bonding; D008298:Maleates / Q000737:chemistry* / Q000145:classification / Q000493:pharmacokinetics*; D008722:Methods; D011145:Polyvinyls / Q000737:chemistry* / Q000145:classification / Q000493:pharmacokinetics*; D011205:Povidone / Q000737:chemistry* / Q000493:pharmacokinetics*; D011760:Pyrrolidinones / Q000737:chemistry; D012826:Silicone Elastomers / Q000737:chemistry; D012995:Solubility; D012996:Solutions; D013059:Spectrum Analysis, Raman; D013678:Technology, Pharmaceutical / Q000639:trends; D014783:Viscosity / Q000187:drug effects; D014867:Water
chemical_list: D000269:Adhesives; D004337:Drug Carriers; D008298:Maleates; D011145:Polyvinyls; D011760:Pyrrolidinones; D012826:Silicone Elastomers; D012996:Solutions; C058026:polyvinylmethoxyethylene-maleic anhydride copolymer; D014867:Water; D004008:Diclofenac; D011205:Povidone; C038678:N-methylpyrrolidone