title: The effects of total-body irradiation on the survival and skin wound healing of rats with combined radiation-wound injury.
abstract: To investigate the effects of total body irradiation on the healing of skin wounds, rats were irradiated with a (60)Co gamma-ray source, in which single doses ranged from 1 to 8 Gy. After irradiation, two whole-thickness circular skin wounds, 22 mm in diameter and covering 2.5% of the total body surface area, were made immediately on the back of each animal. The average healing time for the simple wound was 18.3 +/- 2.1 days, whereas when the wound was combined with 1, 2, 3, 4, 5, and 6 Gy of radiation, the average wound healing time was delayed by 0.3, 0.8, 1.1, 3.5, 6.2, and 9.5 days, respectively. The average healing time was significantly decreased with irradiation doses exceeding 4 Gy, as compared with the healing time for the simple wound without irradiation (p < 0.05). The statistical results showed that the percentage of the unclosed wound with the increased doses in combined radiation injury was significantly proportional to the recovery time kinetics.
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injuries, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China. Ranxize@yahoo.com
authors.forename: Xinze
authors.initials: X
authors.lastname: Ran
authors.forename: Tianmin
authors.initials: T
authors.lastname: Cheng
authors.forename: Chunmeng
authors.initials: C
authors.lastname: Shi
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
authors.forename: Jifu
authors.initials: J
authors.lastname: Qu
authors.forename: Guohe
authors.initials: G
authors.lastname: Yan
authors.forename: Yongping
authors.initials: Y
authors.lastname: Su
authors.forename: Wenchang
authors.initials: W
authors.lastname: Wang
authors.forename: Rufu
authors.initials: R
authors.lastname: Xu
mesh_terms: D000818:Animals; D003037:Cobalt Radioisotopes / Q000008:administration & dosage / Q000097:blood; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000401:mortality; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries / Q000528:radiation effects*; D015996:Survival Rate; D014916:Whole-Body Irradiation / Q000009:adverse effects* / Q000401:mortality; D014945:Wound Healing / Q000528:radiation effects*
chemical_list: D003037:Cobalt Radioisotopes