Two new cytotoxic tetracyclic tetraterpenoids from the soft coral Sarcophyton tortuosum.
Two new cytotoxic tetracyclic tetraterpenoids, methyl tortuoate A (1) and methyl tortuoate B (2), along with the known methyl sartortuoate (3) were isolated from the soft coral Sarcophyton tortuosum. The structures of 1 and 2 were established by spectroscopic methods, mainly on the basis of 2D NMR techniques, and were confirmed by single-crystal X-ray diffraction analysis. The cytotoxic activities of these compounds were carried out in vitro on human nasophyringeal carcinoma (CNE-2) and murine lymphocytic leukemia (P-388) tumor cell lines.
Zeng
Long-Mei
LM
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, People's Republic of China 510275. ceszlm@zsu.edu.cn
Lan
Wen-Jian
WJ
Su
Jing-Yu
JY
Zhang
Guang-Wen
GW
Feng
Xiao-Long
XL
Liang
Yong-Ju
YJ
Yang
Xiao-Ping
XP
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013729:Terpenes; C000607798:methyl sartortuoate; C495050:methyl tortuoate A; C495051:methyl tortuoate B