[Immune male infertility: correction with efferent therapy].
Effects of plasmapheresis and hemosorption on efficacy of the treatment of autoimmune male infertility (AMI) were studied in 289 AMI males with oligoasthenozoospermia aged 19 to 37 years. The males were divided into three groups by the levels of antisperm antibodies (ASAB) in the blood and ejaculate. The study was made of cellular and humoral immunity, intensity of protein and lipid free radical oxidation and antioxidant defense. Patients of group 1 with high ASAB in the blood but low in ejaculate received a course of plasmapheresis. Patients of group 2 with high ASAB both in the blood and ejaculate were subjected to hemosorption and plasmapheresis in one contour. Group 3 patients with high ASAB in ejaculate but low in the blood received efferent therapy only after medication and photomodification of the blood. The treatment reduced elevated levels of ASAB in the blood and ejaculate, normalized free radical oxidation, cellular and humoral immunity, antioxidant defense. This resulted in improvement of spermogram parameters, efficacy of assisted reproductive technologies, higher probability of natural pregnancy in the patients' wives.
Tiktinskiĭ
O L
OL
Koren'kov
D G
DG
Aleksandrov
V P
VP
Mikhaĭlichenko
V V
VV
Marusanov
V E
VE
D000328:Adult; D001323:Autoantibodies / Q000032:analysis / Q000097:blood; D001327:Autoimmune Diseases / Q000628:therapy*; D003131:Combined Modality Therapy; D005609:Free Radicals / Q000378:metabolism; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000276:immunology* / Q000628:therapy*; D010084:Oxidation-Reduction; D010956:Plasmapheresis; D013094:Spermatozoa / Q000276:immunology
D001323:Autoantibodies; D005609:Free Radicals