Treatment of menopausal vasomotor symptoms.
The Women's Health Initiative finding that taking estrogen plus a progestin for more than five years increased the risk of cardiovascular disease and breast cancer left the safety of using estrogen to treat hot flashes open to question. How low a dose and how short a duration would be safe and effective are unknown. Lifestyle changes, antidepressants, alpha-2 agonists, anticonvulsants, phytoestrogens and other dietary supplements have been tried as alternatives to estrogen, with mixed results.
D031885:Cimicifuga; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D008593:Menopause / Q000502:physiology*; D004366:Nonprescription Drugs / Q000627:therapeutic use; D008517:Phytotherapy; D011372:Progestins / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D014666:Vasomotor System / Q000502:physiology*
D004967:Estrogens; D004366:Nonprescription Drugs; D011372:Progestins