[The effect of immunofan on the immunity system characteristics and lipid peroxidation parameters upon acute chemical poisoning].
The results of experiments on Wistar rats under conditions of acute poisoning with 0.75 LD50 of zarin (isopropylmethyl fluorophosphonate), luisite (beta-chlorovinyl dichloroarsine), arsenic chloride, and dichloroethane showed that a four-day treatment with immunofan in a dose of 10 microg/kg restored the immune status characteristics (antibody formation to T-dependent antigen, antibody-dependent cell-mediated cytotoxicity, natural killer cell activity, and delayed type hypersensitivity) and the related LPO parameters.
Zabrodskiĭ
P F
PF
Germanchuk
V G
VG
Nodel'
M L
ML
Vasilenko
O A
OA
Aredakov
A N
AN
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002619:Chemical Warfare Agents / Q000633:toxicity*; D007111:Immunity, Cellular / Q000187:drug effects*; D009842:Oligopeptides / Q000008:administration & dosage*; D011041:Poisoning / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar
D000276:Adjuvants, Immunologic; D002619:Chemical Warfare Agents; D009842:Oligopeptides; C080035:thymohexin