title: Constituents of aromatic plants: carvacrol.
abstract: Carvacrol is a component of numerous aromatic plants. Up to now, no toxicological data were available. Carvacrol show a weak activity in the mutagenicity studies. Moreover, in the metabolism study, carvacrol has shown to be excreted with urine after 24 h in large quantities or unchanged or as glucoronide and sulphate conjugates. The available data do not allow the assessment of the NOEL. Further toxicological studies are needed.
authors.affiliation: Department of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanità, Rome, Italy. mbpsegr@iss.it
authors.forename: M
authors.initials: M
authors.lastname: De Vincenzi
authors.forename: A
authors.initials: A
authors.lastname: Stammati
authors.forename: A
authors.initials: A
authors.lastname: De Vincenzi
authors.forename: M
authors.initials: M
authors.lastname: Silano
mesh_terms: D000818:Animals; D000081007:Cymenes; D004926:Escherichia coli / Q000235:genetics; D005421:Flavoring Agents / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology*; D009152:Mutagenicity Tests; D008517:Phytotherapy; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats
chemical_list: D000081007:Cymenes; D005421:Flavoring Agents; D039821:Monoterpenes; D010938:Plant Oils; C073316:carvacrol