Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant Erythrina crista-galli.
Phomol (1), a novel antibiotic, was isolated from fermentations of a Phomopsis species in the course of a screening of endophytic fungi from the medicinal plant Erythrina crista-galli. For this Argentinean leguminosa antiinflammatory and neuroleptic activities have been described. The compound exhibits antifungal, antibacterial and weak cytotoxic acticity. The antiinflammatory activity was tested in different reporter gene assays (TNF-alpha, STAT1/STAT2 and NF-kappaB) and in an ear edema model in mice. In the reporter gene assays 1 exhibited no activity, whereas 1 showed interesting antiinflammatory activity in the mouse ear assay. The compound is a polyketide lactone and its structure was elucidated by spectroscopic methods.
Weber
Daniela
D
Institute of Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany.
Sterner
Olov
O
Anke
Timm
T
Gorzalczancy
Susanna
S
Martino
Virginia
V
Acevedo
Christina
C
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D001203:Ascomycota / Q000145:classification / Q000302:isolation & purification* / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004895:Erythrina / Q000382:microbiology*; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000382:microbiology*; D013755:Tetradecanoylphorbol Acetate / Q000031:analogs & derivatives / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D007783:Lactones; C494513:phomol; D013755:Tetradecanoylphorbol Acetate