title: Imaging therapeutic response in human bone marrow using rapid whole-body MRI.
abstract: Whole-body imaging of therapeutic response in human bone marrow was achieved without introduced contrast agents using diffusion-weighted echo-planar magnetic resonance imaging of physiologic water. Bone marrow disease was identified relative to the strong overlying signals from water and lipids in other anatomy through selective excitation of the water resonance and generation of image contrast that was dependent upon differential nuclear relaxation times and self-diffusion coefficients. Three-dimensional displays were generated to aid image interpretation. The geometric distortion inherent in echo-planar imaging techniques was minimized through the acquisition of multiple axial slices at up to 12 anatomic stations over the entire body. Examples presented include the evaluation of therapeutic response in bone marrow during cytotoxic therapy for leukemia and metastatic prostate cancer and during cytokine administration for marrow mobilization prior to stem cell harvest.
authors.affiliation: Department of Radiology, Weill Medical College of Cornell University, New York, New York 10021, USA. djb2001@med.cornell.edu
authors.forename: Douglas
authors.initials: D
authors.lastname: Ballon
authors.forename: Richard
authors.initials: R
authors.lastname: Watts
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Dyke
authors.forename: Eric
authors.initials: E
authors.lastname: Lis
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Morris
authors.forename: Howard I
authors.initials: HI
authors.lastname: Scher
authors.forename: Aziz M
authors.initials: AM
authors.lastname: Uluğ
authors.forename: Ann A
authors.initials: AA
authors.lastname: Jakubowski
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D017352:Echo-Planar Imaging / Q000379:methods*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology / Q000628:therapy; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology / Q000628:therapy; D033581:Stem Cell Transplantation
chemical_list: D016179:Granulocyte Colony-Stimulating Factor