Metabolic and hematological effects of dietary supplementation with arginine on rats bearing ascitic Walker 256 tumor.
The notion of using supplementary quantities of arginine for nutritional support in patients with cancer has been evaluated not only as supplement intake of nitrogen substrate but also for its immunopharmacological effects capable of improving the patient's prognosis. The aim of the present study is to evaluate the effects of dietary supplementation with arginine on metastatic dissemination, amino acid metabolism, hematological functions of rats with Walker 256 ascitic tumor. Animals were inoculated intraperitoneally with approximately 4 million cells. Nutritional solutions containing 4 or 6% arginine or just a control diet without added arginine, were administered to the animals via esophagic gavages. The rate of metastasis was lower in animals supplemented with arginine at 4 and 6%. Amino acid metabolism was stimulated in tumor-bearing animals after receiving 4 or 6% arginine, demonstrated by significant increase of arginine, ornithine, citrulline, proline and histidine levels in the blood (p < or = 0.001) when compared to the control diet group. Anemia was less severe in tumor-bearing animals that received arginine supplementation. The findings suggest that arginine supplementation at 6% may have a beneficial effect on to the host, besides its pharmacological action.
Novaes
M R C G
MR
School of Medicine, ESCS/FEPECS, Institute of Human Nutrition, University of Brasilia, Brasilia, DF cep:71,675,000 Brazil. rtianovaes@ig.com.br
Lima
L A M
LA
Novaes
L C G
LC
Souza
M V
MV
D000596:Amino Acids / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use*; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000188:drug therapy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids; D001120:Arginine