title: Dengue vaccine: priorities and progress.
abstract: Dengue transmission has increased considerably in the past 20 years. Currently, it can only be reduced by mosquito control; however, the application of vector-control methods are labor intensive, require discipline and diligence, and are hard to sustain. In this context, a safe dengue vaccine that confers long-lasting protection against infection with the four dengue viruses is urgently required. This review will discuss the requirements of a dengue vaccine, problems, and advances that have been made. Finally, new targets for research will be presented.
authors.affiliation: Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía, Km 6 1\2 P.O. Box Marianao 13, C. Habana, Cuba. lupe@ipk.sld.cu
authors.forename: María G
authors.initials: MG
authors.lastname: Guzmán
authors.forename: Mayra
authors.initials: M
authors.lastname: Muné
authors.forename: Gustavo
authors.initials: G
authors.lastname: Kourí
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends; D003715:Dengue / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D003716:Dengue Virus / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D014765:Viral Vaccines