[Adhesion molecules. Their role in cardiovascular physiopathology].
Adhesion molecules are membrane receptors that mediate several functions related to cell traffic, cell-cell interactions, and cell-matrix contact. There are three important groups associated to cardiovascular disease: integrins, selectins, and the immunoglobulin superfamily. They are involved in the endothelial disfunction and activation processes, and are related to the pathogenesis of coronary artery disease, reperfusion injury, allograft vasculopathy, myocarditis, hypertrophic myocardiopathy, etc. Also, they are related to the mechanism of action of statins. Serologic titer of these molecules has diagnostic and predictive value on diverse cardiovascular diseases. This review focuses on the functions of adhesins and discusses various therapeutic possibilities based on their recognition.
Jaitovich
Ariel
A
Departamento de Biología Celular e Histología, Hospital de Clínicas José de San Martin, Facultad de Medicina, Universidad de Buenos Aires. arieljaitovich@hotmail.com
Jaim Etcheverry
Guillermo
G
D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology*; D015815:Cell Adhesion Molecules / Q000097:blood / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D016023:Integrins / Q000502:physiology
D015815:Cell Adhesion Molecules; D016023:Integrins