Hypoxia in tumors: molecular targets for anti-cancer therapeutics.
Williams
Kaye J
KJ
School of Pharmacy and Pharmaceutical Sciences, The University of Manchester, Manchester M13 9PL, UK.
Cowen
Rachel L
RL
Brown
Louisa M
LM
Chinje
Edwin C
EC
Jaffar
Mohammed
M
Stratford
Ian J
IJ
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000502:physiology; D015195:Drug Design; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D009687:Nuclear Proteins / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; C497442:HIF1A protein, human; C497443:Hif1a protein, mouse; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D014157:Transcription Factors