[Proteoglycan knock-out mice and osteoarthritis].
There are several types of small leucine-rich proteoglycans expressed in articular cartilage and its surrounding tissues. Many of these proteoglycans are functioning as a modulator of collagen fibrillogenesis via binding to the surface of collagen fibers. Therefore, deficiencies of their expression in knock-out mice often result in the formation of abnormal collagen fibers leading to the instability of the join, and finally trigger osteoarthritis.
Shinomura
Tamayuki
T
Tissue Regeneration, Department of Hard Tissue Engineering, Tokyo Medical and Dental University.
D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D017353:Gene Deletion; D007930:Leucine; D051379:Mice; D018345:Mice, Knockout; D010003:Osteoarthritis / Q000235:genetics*; D011509:Proteoglycans / Q000737:chemistry / Q000172:deficiency / Q000235:genetics* / Q000502:physiology
D011509:Proteoglycans; D003094:Collagen; D007930:Leucine