Koboquinone A and B, new metabolites of kobophenol a in rats.
Two new phase I metabolites of phytoestrogen kobophenol A (1), called koboquinone A (2) and B (3), have been isolated from the feces of rats orally administered 1. Their structures were determined by spectroscopic methods. 2 also showed activity of stimulating the proliferation of cultured osteoblasts.
Liang
Gaolin
G
The School of Pharmacy, Fudan University, Shanghai, China.
Cheng
Kejun
K
Zhou
Hong
H
Hu
Changqi
C
D000818:Animals; D016227:Benzoquinones / Q000737:chemistry*; D001711:Biotransformation; D049109:Cell Proliferation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010006:Osteoblasts / Q000187:drug effects; D048789:Phytoestrogens / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D016227:Benzoquinones; D048789:Phytoestrogens; C499874:koboquinone A; C499873:koboquinone B