Effect of gender on reporting of MMR adverse events in Saudi Arabia.
We evaluated the safety of a measles-mumps-rubella (MMR) immunization campaign for Saudi children (age range: 6-13 years) and gender differences in reporting post-MMR adverse events. After vaccinations were administered, we monitored 160 schools for 14 days and 19 hospitals in the 8 cities under study for 10 weeks. Incidence rates were: all MMR adverse events, 26.5/10,000 MMR vaccines (significantly higher in females than males); Urabe strain aseptic meningitis, 1.0/295,000; fever, 40.2/10,000 (females) and 0.9/10,000 (males); and parotitis, 5.4/10,000 (females) and 0.9/10,000 (males). Combined MMR vaccine containing the Urabe mumps strain was safe for children aged 6-13 years. Gender differences regarding reactogenicity were evident and should be considered when designing future studies.
Khalil
M K
MK
King Fahd Specialist Hospital, Buraidah, Saudi Arabia.
Al-Mazrou
Y Y
YY
Al-Ghamdi
Y S
YS
Tumsah
S
S
Al-Jeffri
M
M
Meshkhas
A
A
D000293:Adolescent; D016907:Adverse Drug Reaction Reporting Systems / Q000592:standards*; D015992:Body Mass Index; D002648:Child; D003625:Data Collection / Q000592:standards*; D004342:Drug Hypersensitivity / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D017589:Immunization Programs / Q000458:organization & administration; D015994:Incidence; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects* / Q000378:metabolism / Q000493:pharmacokinetics; D008582:Meningitis, Aseptic / Q000453:epidemiology / Q000209:etiology; D008657:Metabolic Clearance Rate; D010309:Parotitis / Q000453:epidemiology / Q000209:etiology; D011159:Population Surveillance; D015397:Program Evaluation; D012307:Risk Factors; D012449:Safety; D012529:Saudi Arabia / Q000453:epidemiology; D012727:Sex Characteristics; D017678:Sex Distribution
D022542:Measles-Mumps-Rubella Vaccine