[The extraction and effects on mouse lymphocyte proliferation of immunoregulation components from Lysimachia hemsleyana].
OBJECTIVE
To study the effects of extracted fractions from the whole plants of Lysimachia hemsleyana Maxim on the proliferation ability of lymphocytes in mice in vitro.


METHODS
We extracted the components by using of ethanol, ether from petroleum, chloroform, ethyl acetate and n-butanol, successively then study them on the proliferation of lymphocytes in mice.


RESULTS
The n-butanol fraction obviously inhibited the proliferation of spleen lymphocytes induced by LPS, bilaterally regulated the T lymphocyte proliferation induced by ConA. The chloroform fraction markedly enhanced the lymphocytes proliferation induced by ConA or LPS.


CONCLUSIONS
The results suggested that n-butanol fraction and chloroform fraction from Lysimachia hemsleyana possibly maybe have immunoregulation effects.
Zhang
Lanling
L
Department of Rheumatology, Changhai Hospital, Second Military Medical University, Shanghai.
Meng
Jiming
J
Chen
Haisheng
H
Han
Xinghai
X
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D029623:Primulaceae / Q000737:chemistry*
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal