title: Aminothiazole inhibitors of HCV RNA polymerase.
abstract: Aminothiazole-based inhibitors designed for HCV polymerase display low micromolar potencies in biochemical assays. These compounds show a stringent preference for a cyclohexyl hydrophobe at the 2-amino position. The composition of these compounds suggests that they may be interacting at a recently discovered allosteric site on the polymerase.
authors.affiliation: NeoGenesis Pharmaceuticals Inc., Department of Chemistry, 840 Memorial Drive, Cambridge, MA 02139, USA. shipps@neogenesis.com
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Shipps
authors.forename: Yongqi
authors.initials: Y
authors.lastname: Deng
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.forename: Janeta
authors.initials: J
authors.lastname: Popovici-Muller
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Curran
authors.forename: Kristin E
authors.initials: KE
authors.lastname: Rosner
authors.forename: Alan B
authors.initials: AB
authors.lastname: Cooper
authors.forename: Viyyoor
authors.initials: V
authors.lastname: Girijavallabhan
authors.forename: Nancy
authors.initials: N
authors.lastname: Butkiewicz
authors.forename: Michael
authors.initials: M
authors.lastname: Cable
mesh_terms: D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D016174:Hepacivirus / Q000201:enzymology*; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013844:Thiazoles; D012321:DNA-Directed RNA Polymerases