Roles of JUMONJI in mouse embryonic development.
Cardiac development is a complex biological process requiring the integration of cell specification, differentiation, migration, proliferation, and morphogenesis. Although significant progress has been made recently in understanding the molecular basis of cardiac development, mechanisms of transcriptional control of cardiac development remain largely unknown. In search for the developmentally important genes, the jumonji gene (jmj) was identified by gene trap technology and characterized as a critical nuclear factor for mouse embryonic development. Jmj has been shown to play important roles in cardiovascular development, neural tube fusion process, hematopoiesis, and liver development in mouse embryos. The amino acid sequence of the JUMONJI protein (JMJ) reveals that JMJ belongs to the AT-rich interaction domain transcription factor family and more recently has been described as a member of the JMJ transcription factor family. Here, we review the roles of jmj in multiple organ development with a focus on cardiovascular development in mice.
Jung
Jooyoung
J
Department of Anatomy, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA.
Mysliwiec
Matthew R
MR
Lee
Youngsook
Y
D000818:Animals; D002319:Cardiovascular System; D002453:Cell Cycle; D002465:Cell Movement; D002467:Cell Nucleus / Q000378:metabolism; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D006579:Heterozygote; D006720:Homozygote; D008099:Liver / Q000196:embryology; D051379:Mice; D008953:Models, Anatomic; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009432:Neural Crest / Q000196:embryology; D063151:Polycomb Repressive Complex 2; D017434:Protein Structure, Tertiary; D013997:Time Factors; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
C093650:Jarid2 protein, mouse; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; D063151:Polycomb Repressive Complex 2