[Radiation-induced rat cerebral neuron apoptosis].
OBJECTIVE
To explore the correlation between X-ray-induced rat cerebral neuron apoptosis and radiation doses.


METHODS
In a controlled experiment, the rats in the experimental group received X-ray radiation at different doses (2, 4, 6 and 8 Gy), and the apoptotic cerebral neurons were counted after in situ end-labeling and immunohistochemical staining.


RESULTS
X-ray radiation induced apoptosis of rat cerebral neurons, and the apoptotic rate varied with the radiation doses. Significant difference in the apoptotic rate was noted before and after radiation (P<0.0001), and between different radiation dose groups (P<0.005). The apoptotic rate differed significantly at different time points after the radiation.


CONCLUSIONS
Low or medium doses of X-ray is able to induce rat cerebral neuron apoptosis depending on the radiation doses and following a definable time course.
Feng
Wen-feng
WF
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. fengwf@fimmu.com
Qi
Song-tao
ST
Qiu
Bing-hui
BH
Yang
Kai-jun
KJ
Huang
Li-jing
LJ
D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D002540:Cerebral Cortex / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D009474:Neurons / Q000473:pathology / Q000528:radiation effects*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors