title: N-phosphoryl amino acids and biomolecular origins.
abstract: The possible role of phosphoryl amino acids for biomolecular origins is briefly reviewed. Peptide formation, ester formation, ester exchange on phosphorus and N to O migration occurred when the N-phosphoryl amino acid was incubated at room temperature. Short nucleotides and peptides were formed when nucleoside was reacted with N-phosphoryl amino acid at room temperature. Serine and threonine residues in their conjugate with different nucleosides (mediated with phosphorus) showed different self-cleavage activities. N-phosphoryl Histine and Ser-His dipeptide could cleave nucleic acids, proteins and esters in neutral medium. Based on a simple model, a pathway of 'co-evolution of protein and nucleic acid' was proposed.
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, PR China.
authors.forename: C M
authors.initials: CM
authors.lastname: Cheng
authors.forename: X H
authors.initials: XH
authors.lastname: Liu
authors.forename: Y M
authors.initials: YM
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Ma
authors.forename: B
authors.initials: B
authors.lastname: Tan
authors.forename: R
authors.initials: R
authors.lastname: Wan
authors.forename: Y F
authors.initials: YF
authors.lastname: Zhao
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D010758:Phosphorus
chemical_list: D000596:Amino Acids; D004952:Esters; D009705:Nucleosides; D009711:Nucleotides; D010455:Peptides; D010758:Phosphorus