title: Presumed pharmacologically induced change from upbeat- to downbeat nystagmus in a patient with Wernicke's encephalopathy.
abstract: A case of Wernicke's encephalopathy due to proven thiamine deficiency suffering from upbeat nystagmus (UN) changing to downbeat nystagmus (DN) after a latency of 1 year is presented. The case was also notable for the finding of positive oligoclonal bands in the CSF. The underlying pathophysiological mechanisms and a possible effect of baclofen treatment are discussed.
authors.affiliation: Department of Neurology, University of Essen, Hufelandstr 55, 45122 Essen, Germany. oliver.kastrup@uni-essen.de
authors.forename: O
authors.initials: O
authors.lastname: Kastrup
authors.forename: M
authors.initials: M
authors.lastname: Maschke
authors.forename: M
authors.initials: M
authors.lastname: Keidel
authors.forename: H C
authors.initials: HC
authors.lastname: Diener
mesh_terms: D000328:Adult; D001418:Baclofen / Q000009:adverse effects*; D004584:Electronystagmography; D005260:Female; D018755:GABA Agonists / Q000009:adverse effects*; D006801:Humans; D009759:Nystagmus, Pathologic / Q000209:etiology*; D012027:Reflex, Vestibulo-Ocular / Q000187:drug effects; D014899:Wernicke Encephalopathy / Q000150:complications*
chemical_list: D018755:GABA Agonists; D001418:Baclofen