title: Neutralization profiles of newly transmitted human immunodeficiency virus type 1 by monoclonal antibodies 2G12, 2F5, and 4E10.
abstract: As the AIDS epidemic continues unabated, the development of a human immunodeficiency virus (HIV) vaccine is critical. Ideally, an effective vaccine should elicit cell-mediated and neutralizing humoral immune responses. We have determined the in vitro susceptibility profile of sexually transmitted viruses from 91 patients with acute and early HIV-1 infection to three monoclonal antibodies, 2G12, 2F5, and 4E10. Using a recombinant virus assay to measure neutralization, we found all transmitted viruses were neutralized by 4E10, 80% were neutralized by 2F5, and only 37% were neutralized by 2G12. We propose that the induction of 4E10-like antibodies should be a priority in designing immunogens to prevent HIV-1 infection.
authors.affiliation: Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Ave., 7th Floor, New York, NY 10016, USA.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Mehandru
authors.forename: Terri
authors.initials: T
authors.lastname: Wrin
authors.forename: Justin
authors.initials: J
authors.lastname: Galovich
authors.forename: Gabriela
authors.initials: G
authors.lastname: Stiegler
authors.forename: Brigitta
authors.initials: B
authors.lastname: Vcelar
authors.forename: Arlene
authors.initials: A
authors.lastname: Hurley
authors.forename: Christine
authors.initials: C
authors.lastname: Hogan
authors.forename: Sandhya
authors.initials: S
authors.lastname: Vasan
authors.forename: Hermann
authors.initials: H
authors.lastname: Katinger
authors.forename: Christos J
authors.initials: CJ
authors.lastname: Petropoulos
authors.forename: Martin
authors.initials: M
authors.lastname: Markowitz
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology*; D005260:Female; D015483:HIV Antibodies / Q000008:administration & dosage / Q000276:immunology*; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D009500:Neutralization Tests; D011995:Recombination, Genetic; D012725:Sexual Behavior
chemical_list: D000911:Antibodies, Monoclonal; D015483:HIV Antibodies