Limiting brain and lung damage after coronary artery bypass grafting: an alternative to conventional coronary artery bypass graft.
The development of coronary artery bypass graft (CABG) for the treatment of coronary heart disease has resulted in reduced morbidity and mortality compared with medical therapy. Even with the rapid development of improved percutaneous interventions, CABG remains an important approach for treating patients with advanced coronary heart disease. However, recent studies and commentary reporting an alarmingly high incidence of subtle, cognitive decline following CABG have generated questions about whether these adverse outcomes could be lessened. Even after considerable study, there is no consensus as to the cause of brain and lung injury after CABG and cardiopulmonary bypass, nor an agreed upon, mechanistic approach to study its prevention. The potential causes of these adverse outcomes and a simple approach are described, involving the use of the cannulae, biventricular pulsatile flow pump, and a blood substitute to optimize the perfusion of brain and alveolar cells, minimize systemic microembolization, and limit post-CABG cognitive decline.
Runge
Thomas M
TM
Biomedical Engineering Program, University of Texas at Austin, Austin, Texas, USA.
Runge
Marschall S
MS
D001802:Blood Substitutes / Q000627:therapeutic use; D001930:Brain Injuries / Q000209:etiology / Q000517:prevention & control*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003327:Coronary Disease / Q000601:surgery*; D006438:Hemodilution / Q000009:adverse effects; D006801:Humans; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000517:prevention & control; D012307:Risk Factors
D001802:Blood Substitutes