title: [VDR function in skin].
abstract: Typical abnormalities of hereditary rickets type II patients were observed in the mice deficient of VDR with growth retardation, impaired bone formation and alopecia. Except alopecia, all of the abnormalities were rescued by dietary supplement of high minerals. Genetic mutations in the critical vitamin D biosynthesis enzyme in humans and mice also suffer rachtic phenotypes except alopecia. The function of VDR in skin will be discussed.
authors.affiliation: IMCB, University of Tokyo.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Kato
authors.forename: Yamamoto
authors.initials: Y
authors.lastname: Yoko
mesh_terms: D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000172:deficiency / Q000235:genetics; D000505:Alopecia / Q000209:etiology; D000818:Animals; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000209:etiology; D009154:Mutation; D018167:Receptors, Calcitriol / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D014807:Vitamin D / Q000502:physiology
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase