title: Aetiology, classification and pathogenesis of pulp and periapical disease.
abstract: At present, the majority of the treatments that are performed in the clinic are due to disease entities involving the dental pulp and periapex. Dental pulp is a richly vascularized and innervated tissue, enclosed by surrounding tissues that are incapable of expanding, such as dentin. It has terminal blood flow and small-gauge circulatory access the periapex. All of these characteristics severely constrain the defensive capacity of the pulp tissue when faced with the different aggressions it may be subjected to. Pulp tissue can also be affected by a retrograde infection, arising from the secondary canaliculi, from the periodontal ligament or from the apex during the course of periodontitis. Due to the fact that periapical disease is almost inevitably preceded by pulp disease, we shall begin by describing the causes of pulp disease and will then proceed to a discussion of the causes of periapical disease. The course of illness and classification of these pathological entities will depend on the aetiology involved. We will analyse pulp necrosis and pulp degeneration that are capable of triggering reversible apical periodontitis or irreversible apical periodontitis.
authors.affiliation: Facultad de Medicina y Odontología, Universidad de Salamanca, Salamanca. jflmarcos@usal.es
authors.forename: Joaquín F
authors.initials: JF
authors.lastname: López-Marcos
mesh_terms: D003790:Dental Pulp Necrosis / Q000145:classification / Q000150:complications / Q000209:etiology; D018450:Disease Progression; D006801:Humans; D010485:Periapical Periodontitis / Q000145:classification / Q000150:complications / Q000209:etiology; D011671:Pulpitis / Q000145:classification / Q000150:complications / Q000209:etiology