[Vitamin D nuclear receptor and its signal transduction].
Vitamin D (VD) suppresses keratinocyte growth and induces its differentiation by binding to VD receptor. VD increases expression of phopholipase C and involucrin through VD response elements in the promoter. Vitamin D receptor (VDR) recruits mainly DRIP (vitamin D receptor interacting protein) during keratinocyte proliferation, but SRC (steroid receptor coactivator) during differentiation.
Inui
Shigeki
S
Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University.
D000123:Acetyltransferases / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D004790:Enzyme Induction; D051548:Histone Acetyltransferases; D006801:Humans; D015603:Keratinocytes / Q000166:cytology*; D056892:Mediator Complex; D009687:Nuclear Proteins / Q000502:physiology; D011401:Promoter Regions, Genetic; D011498:Protein Precursors / Q000235:genetics / Q000502:physiology; D018167:Receptors, Calcitriol / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology; D010738:Type C Phospholipases / Q000378:metabolism / Q000502:physiology; D014807:Vitamin D / Q000378:metabolism / Q000502:physiology*
C113182:DRIP, VDR interacting protein complex; D056892:Mediator Complex; D009687:Nuclear Proteins; D011498:Protein Precursors; D018167:Receptors, Calcitriol; D015534:Trans-Activators; D014807:Vitamin D; C032253:involucrin; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D010738:Type C Phospholipases; D002118:Calcium