Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation.
A concept in Parkinson's disease postulates that motor cortex may pattern abnormal rhythmic activities in the basal ganglia, underlying the genesis of observed motor symptoms. We conducted a preclinical study of electrical interference in the primary motor cortex using a chronic MPTP primate model in which dopamine depletion was progressive and regularly documented using 18F-DOPA positron tomography. High-frequency motor cortex stimulation significantly reduced akinesia and bradykinesia. This behavioral benefit was associated with an increased metabolic activity in the supplementary motor area as assessed with 18-F-deoxyglucose PET, a normalization of mean firing rate in the internal globus pallidus (GPi) and the subthalamic nucleus (STN), and a reduction of synchronized oscillatory neuronal activities in these two structures. Motor cortex stimulation is a simple and safe procedure to modulate subthalamo-pallido-cortical loop and alleviate parkinsonian symptoms without requiring deep brain stereotactic surgery.
Drouot
Xavier
X
URA CEA-CNRS 2210, Service Hospitalier Frédéric Joliot, 91401 Orsay, France.
Oshino
Satoru
S
Jarraya
Bechir
B
Besret
Laurent
L
Kishima
Haruhiko
H
Remy
Philippe
P
Dauguet
Julien
J
Lefaucheur
Jean Pascal
JP
Dollé
Frédéric
F
Condé
Françoise
F
Bottlaender
Michel
M
Peschanski
Marc
M
Kéravel
Yves
Y
Hantraye
Philippe
P
Palfi
Stéphane
S
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004594:Electrophysiology; D019788:Fluorodeoxyglucose F18; D020267:MPTP Poisoning / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009044:Motor Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology; D010215:Papio; D010300:Parkinson Disease / Q000503:physiopathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D020127:Recovery of Function
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18