title: BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis.
abstract: Blood samples from 132 consecutive hematopoietic stem cell transplant recipients were obtained and tested weekly for BK virus DNA by use of quantitative real-time PCR. Forty-four patients (33%) developed BK viremia at a median of 41 days (range, 9-91 days) after transplantation. Patients with hemorrhagic cystitis that occurred after platelet engraftment had higher levels of viremia than did patients without hemorrhagic cystitis (median, 9.7x10(3) vs. 0 copies/mL; P=.008) and patients with hemorrhagic cystitis that occurred before platelet engraftment (median, 9.7x10(3) vs. 0 copies/mL; P=.0006). BK viremia also was strongly associated with postengraftment hemorrhagic cystitis in a time-dependent analysis (P=.004).
authors.affiliation: Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
authors.forename: Veronique
authors.initials: V
authors.lastname: Erard
authors.forename: Barry
authors.initials: B
authors.lastname: Storer
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
authors.forename: Jennifer
authors.initials: J
authors.lastname: Nollkamper
authors.forename: Meei-Li
authors.initials: ML
authors.lastname: Huang
authors.forename: Ajit
authors.initials: A
authors.lastname: Limaye
authors.forename: Michael
authors.initials: M
authors.lastname: Boeckh
mesh_terms: D001739:BK Virus; D003556:Cystitis / Q000503:physiopathology*; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006412:Hematopoietic Stem Cells; D006470:Hemorrhage / Q000503:physiopathology*; D006801:Humans; D027601:Polyomavirus Infections / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors