Angiotensin-converting enzyme insertion-deletion polymorphism in primary open-angle glaucoma.
OBJECTIVE
To investigate the hypothesis that primary open-angle glaucoma (POAG) is associated with a common insertion-deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene.


METHODS
ACE I/D polymorphism was investigated in a control group of healthy subjects (n = 101) and in a group of patients diagnosed with POAG (n = 104). Polymerase chain reaction detection of I/D polymorphism was used to determine the presence of the two ACE alleles in the groups.


RESULTS
Neither the I/D genotype distributions nor the allele frequencies differed significantly between POAG and control subjects (DD genotype 34.6 vs. 39.6%; ID genotype 53.9 vs. 40.6%; II genotype 11.5 vs. 19.8%, p = 0.1; D allele 61.5 vs. 60%; I allele 38.5 vs. 40%, p = 0.8).


CONCLUSIONS
We could not identify a possible association of the I/D polymorphism in the ACE gene with POAG, however further studies with larger patient numbers in different populations are required to clarify the role of ACE gene in susceptibility to POAG.
Ozkur
Mehtap
M
Department of Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. aozkur@hotmail.com
Erbagci
Ibrahim
I
Gungor
Kivanc
K
Nacak
Muradiye
M
Aynacioglu
Sukru
S
Bekir
Necdet A
NA
D005260:Female; D017353:Gene Deletion; D005902:Glaucoma, Open-Angle / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A