title: Glucocorticoids increase in vitro and in vivo activities of antibiotics against Chlamydophila pneumoniae.
abstract: The in vitro and in vivo antichlamydial activities of dexamethasone and beclomethasone alone and in combination with an antibiotic were tested. In vitro, dexamethasone and beclomethasone decreased the number of inclusion-forming units versus the control number (P < 0.001). The combination of glucocorticoids with azithromycin, telithromycin, or levofloxacin was more active than antibiotics used alone (P < 0.001). The combination, tested in a murine Chlamydophila pneumoniae infection model, produced similar results.
authors.affiliation: Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Milan, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Caronzolo
authors.forename: Valeria
authors.initials: V
authors.lastname: Lucini
authors.forename: Marilou
authors.initials: M
authors.lastname: Pannacci
authors.forename: Silvia
authors.initials: S
authors.lastname: Grosso
authors.forename: Federica
authors.initials: F
authors.lastname: Colleoni
authors.forename: Franco
authors.initials: F
authors.lastname: Fraschini
authors.forename: Francesco
authors.initials: F
authors.lastname: Scaglione
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D017963:Azithromycin / Q000494:pharmacology / Q000627:therapeutic use; D002460:Cell Line; D023521:Chlamydophila Infections / Q000188:drug therapy* / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use; D004357:Drug Synergism; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D048628:Ketolides / Q000494:pharmacology / Q000627:therapeutic use; D064704:Levofloxacin; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D048628:Ketolides; D064704:Levofloxacin; D003907:Dexamethasone; D017963:Azithromycin; D015242:Ofloxacin; C106791:telithromycin