title: [Compression vertebral fracture in osteoporosis--prevention and treatment].
abstract: Vertebral fractures are the earliest and most common osteoporotic fractures. Usually vertebral fractures are associated with following clinical symptoms: back pain, posture change, loss of height, functional impairment, disability and decreasing quality of life. After 3 years of treatment raloxifene reduced the risk of first vertebral fracture by 55%. The fracture risk within one year was reduced by as much as 68%. The continued observation proved its sustained efficacy in further reduction of the fracture risk by 50% in the fourth year.
authors.affiliation: Odjel za fizikalnu medicinu, rehabilitaciju i reumatologiju Klinicka bolnica Split, Marmontova 4, 21000 Split.
authors.forename: Tonko
authors.initials: T
authors.lastname: Vlak
mesh_terms: D000368:Aged; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000188:drug therapy*; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use; D016103:Spinal Fractures / Q000209:etiology* / Q000517:prevention & control* / Q000628:therapy
chemical_list: D020849:Raloxifene Hydrochloride