title: Portal vein thrombosis during antineoplastic chemotherapy in children: report of five cases and review of the literature.
abstract: We report five paediatric cases of portal vein thrombosis (PVT) occurring during chemotherapy, observed in two institutions over an 8-year time period. These children aged 2.5-15 years were treated for Burkitt's lymphoma, Ewing's tumour, small cell bone tumour or medulloblastoma. PVT was diagnosed on colour Doppler ultrasonography (US). In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan. In one case, PVT occurred in the absence of HVOD in a patient with pre-existing periportal lymphomatous infiltration. Four patients experienced persistent portal hypertension, which resulted in death in one. PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.
authors.affiliation: Imaging Department, Institut Curie, 26 rue d'Ulm, 75005 Paris, France. herve.brisse@curie.net
authors.forename: H
authors.initials: H
authors.lastname: Brisse
authors.forename: D
authors.initials: D
authors.lastname: Orbach
authors.forename: N
authors.initials: N
authors.lastname: Lassau
authors.forename: V
authors.initials: V
authors.lastname: Servois
authors.forename: F
authors.initials: F
authors.lastname: Doz
authors.forename: D
authors.initials: D
authors.lastname: Debray
authors.forename: S
authors.initials: S
authors.lastname: Helfre
authors.forename: O
authors.initials: O
authors.lastname: Hartmann
authors.forename: S
authors.initials: S
authors.lastname: Neuenschwander
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*; D011169:Portal Vein; D012307:Risk Factors; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents; D006493:Heparin