title: The ArrayExpress gene expression database: a software engineering and implementation perspective.
abstract: BACKGROUND
  The lack of microarray data management systems and databases is still one of the major problems faced by many life sciences laboratories. While developing the public repository for microarray data ArrayExpress we had to find novel solutions to many non-trivial software engineering problems. Our experience will be both relevant and useful for most bioinformaticians involved in developing information systems for a wide range of high-throughput technologies.
  
  
  RESULTS
  ArrayExpress has been online since February 2002, growing exponentially to well over 10,000 hybridizations (as of September 2004). It has been demonstrated that our chosen design and implementation works for databases aimed at storage, access and sharing of high-throughput data.
  
  
  BACKGROUND
  The ArrayExpress database is available at http://www.ebi.ac.uk/arrayexpress/. The software is open source.
  
  
  BACKGROUND
  ugis@ebi.ac.uk.
authors.affiliation: EMBL Outstation-Hinxton, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. ugis@ebi.ac.uk
authors.forename: Ugis
authors.initials: U
authors.lastname: Sarkans
authors.forename: Helen
authors.initials: H
authors.lastname: Parkinson
authors.forename: Gonzalo Garcia
authors.initials: GG
authors.lastname: Lara
authors.forename: Ahmet
authors.initials: A
authors.lastname: Oezcimen
authors.forename: Anjan
authors.initials: A
authors.lastname: Sharma
authors.forename: Niran
authors.initials: N
authors.lastname: Abeygunawardena
authors.forename: Sergio
authors.initials: S
authors.lastname: Contrino
authors.forename: Ele
authors.initials: E
authors.lastname: Holloway
authors.forename: Philippe
authors.initials: P
authors.lastname: Rocca-Serra
authors.forename: Gaurab
authors.initials: G
authors.lastname: Mukherjee
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Shojatalab
authors.forename: Misha
authors.initials: M
authors.lastname: Kapushesky
authors.forename: Susanna-Assunta
authors.initials: SA
authors.lastname: Sansone
authors.forename: Anna
authors.initials: A
authors.lastname: Farne
authors.forename: Tim
authors.initials: T
authors.lastname: Rayner
authors.forename: Alvis
authors.initials: A
authors.lastname: Brazma
mesh_terms: D000465:Algorithms; D003628:Database Management Systems; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000379:methods*; D033181:Information Dissemination / Q000379:methods; D016247:Information Storage and Retrieval / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D012984:Software
chemical_list: D011506:Proteins