Gastro-oesophageal reflux and bronchial asthma: current status and future directions.
In recent years there have been several reports suggesting an association between bronchial asthma and gastro-oesophageal reflux; however a cause and effect relationship has not been proven yet. Confirmation of such a relationship is likely to have far reaching implications on the management of asthma. Reliable assessment of this issue is hampered by the presence of various lacunae in most of the published studies. Hence it is essential to carefully examine the strength of data suggesting a link between asthma and reflux. This article critically analyses currently available literature on the subject (including published reviews, meta-analyses, and randomised clinical trials in the English language) and summarises valid conclusions that can be drawn; it also proposes a framework for future studies to resolve the issue.
Mathew
J L
JL
Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India. jlmathew@hotmail.com
Singh
M
M
Mittal
S K
SK
D001249:Asthma / Q000150:complications* / Q000453:epidemiology; D003625:Data Collection / Q000379:methods; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000453:epidemiology; D017408:Guidelines as Topic; D006801:Humans; D015995:Prevalence; D012107:Research Design