Cortical and limbic excitability in rats with absence epilepsy.
The classical cortico-reticular theory on absence epilepsy suggests that a hyperexcitable cortex is a precondition for the occurrence of absence seizures. In the present experiment seizure thresholds and characteristics of cortical and limbic epileptic afterdischarges (AD) were determined in a comparative cortical stimulation study in young and old adult genetically epileptic WAG/Rij, congenic ACI and Wistar rats. Fifteen-second series of 8Hz stimulation of the sensory-motor cortex were applied in 80- and 180-day-old rats with implanted electrodes. Strain differences were found for the threshold for movements directly induced by stimulation, low frequency spike-and-wave AD, maximal clonic intensity of seizures accompanying direct stimulation, and frequency characteristics of low frequency AD. None of these results agreed with a higher cortical excitability exclusively in WAG/Rij rats. However, WAG/Rij rats had the longest duration of the low frequency AD, and the lowest threshold for the transition to the limbic type of AD. The decrease of this threshold correlated with the increase of the incidence and total duration of spontaneous SWDs in WAG/Rij rats. It is concluded that the elevated excitability of the limbic system or pathways mediating the spread of the epileptic activity into this system can be attributed to the development of genetic epileptic phenotype in WAG/Rij rats.
Tolmacheva
Elena A
EA
Biological Faculty, M.V. Lomonosov Moscow State University, Moscow, Russia.
van Luijtelaar
Gilles
G
Chepurnov
Serguei A
SA
Kaminskij
Yulij
Y
Mares
Pavel
P
D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology / Q000528:radiation effects*; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods / Q000528:radiation effects; D004832:Epilepsy, Absence / Q000235:genetics / Q000503:physiopathology*; D008032:Limbic System / Q000502:physiology / Q000528:radiation effects*; D008297:Male; D009068:Movement / Q000528:radiation effects; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D012684:Sensory Thresholds / Q000528:radiation effects; D013045:Species Specificity; D013997:Time Factors