Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.
A new ubiquitin-activating enzyme (E1) inhibitor, himeic acid A, was isolated from a culture of marine-derived fungus, Aspergillus sp. The structure was determined by spectroscopic analysis. The formation of an E1-ubiquitin (Ub) intermediate was 65% inhibited by himeic acid A at the concentration of 50 microM, while two new related compounds, himeic acids B and C, showed little inhibitory activity even at 100 microM.
Tsukamoto
Sachiko
S
Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920-1192, Japan. sachiko@p.kanakawa-u.ac.jp
Hirota
Hiroshi
H
Imachi
Misako
M
Fujimuro
Masahiro
M
Onuki
Hiroyuki
H
Ohta
Tomihisa
T
Yokosawa
Hideyoshi
H
D001230:Aspergillus / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology*; D008386:Marine Biology; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D044764:Ubiquitin-Activating Enzymes / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D005231:Fatty Acids, Unsaturated; D011753:Pyrones; C500027:himeic acid A; D044764:Ubiquitin-Activating Enzymes