Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase.
A novel series of heterocyclic sulfoxides and sulfones was prepared and examined as potential inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for inactivation of neuromodulating fatty acid amides including anandamide and oleamide.
Du
Wu
W
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Hardouin
Christophe
C
Cheng
Heng
H
Hwang
Inkyu
I
Boger
Dale L
DL
D000581:Amidohydrolases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*; D013454:Sulfoxides / Q000737:chemistry*; D000099252:Fatty Acid Amide Hydrolases
D000581:Amidohydrolases; D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D013450:Sulfones; D013454:Sulfoxides; D000099252:Fatty Acid Amide Hydrolases