[Characterization of SN-6, a novel exchange inhibitor and its renal protective effect].
Recently, we developed 2-(4- [4-nitrobenzyloxy] benzyl) thiazolidine-4-carboxylic acid ethyl ester (SN-6), a newly synthesized and selective inhibitor of Na(+)/Ca(2+) exchanger. SN-6 is a selective inhibitor for the Ca(2+) influx mode of Na(+)/Ca(2+) exchanger. And this compound attenuated hypoxia/reoxygenation-induced renal tubular cell damage and ischemia/reperfusion-induced renal failure. These results suggest that SN-6 is expected to be pharmacological tools to study the roles of the exchanger and a new anti-ischemic drug.
Inoue
Yutaka
Y
Laboratory for Discovery Research, Pharmaceutical Research & Development Division, Senju Pharmaceutical Co. Ltd.
Ito
Kazuhiko
K
Sakaue
Takahiro
T
Iwamoto
Takahiro
T
Kita
Satomi
S
D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D006224:Cricetinae; D003864:Depression, Chemical; D004195:Disease Models, Animal; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007511:Ischemia / Q000188:drug therapy*; D007684:Kidney Tubules / Q000098:blood supply*; D018374:LLC-PK1 Cells; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000150:complications / Q000188:drug therapy; D019831:Sodium-Calcium Exchanger / Q000037:antagonists & inhibitors*; D013552:Swine; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use; D053778:Thiazolidines
C487681:2-(4-(4-nitrobenzyloxy)benzyl)thiazolidine-4-carboxylic acid ethyl ester; D001593:Benzyl Compounds; D019831:Sodium-Calcium Exchanger; D013844:Thiazoles; D053778:Thiazolidines; D000255:Adenosine Triphosphate; D002118:Calcium