Delayed-onset temporary auditory threshold shift following head blow in guinea pigs.
This study attempts to investigate the development of sensorineural hearing loss following a head blow without skull fracture in association with physiological and histopathologic changes in an experimental animal model. With the head in a freely movable position, albino guinea pigs were given a single blow to the occipital region by a head blow device. At 1, 7, and 14 days after the blow, the animals' auditory brainstem response (ABR) and cochlear microphonics (CM) were examined, and both the temporal bone and brain stem were observed by light and electron microscopy. The ABR threshold was unchanged at day 1, was significantly increased at day 7, and was fully recovered at day 14. The I-V and I-II interpeak latencies were significantly prolonged at days 1 and 7, and wave I latency was significantly prolonged at day 7 only. These latencies were recovered to normal limits at day 14. On the other hand, no significant change in CM versus the control group was observed at any point in the measurements. Histopathologically, no abnormal finding was seen at the light microscopic level. However, at the electron microscopic level, there were some injuries to the eighth nerve. At day 1, the lamellar structure of the myelin sheath was irregular, and the periaxonal space was expanded; at day 7, the myelin sheath was disintegrated. At day 14, however, these changes were partially reversed. These results suggest that sensorineural hearing loss following a head blow in this model is attributed to dysfunction of the eighth nerve rather than to cochlear impairment.
Tokui
Naokimi
N
Department of Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. n-tokui@med.uoeh-u.ac.jp
Suzuki
Hideaki
H
Udaka
Tsuyoshi
T
Hiraki
Nobuaki
N
Fujimura
Takeyuki
T
Fujimura
Kazunobu
K
Makishima
Kazumi
K
D000818:Animals; D001309:Auditory Threshold / Q000502:physiology*; D003055:Cochlear Microphonic Potentials; D006259:Craniocerebral Trauma / Q000150:complications*; D004195:Disease Models, Animal; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005260:Female; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D046529:Microscopy, Electron, Transmission; D008859:Microscopy, Polarization; D009186:Myelin Sheath / Q000473:pathology / Q000648:ultrastructure; D013701:Temporal Bone / Q000473:pathology; D013997:Time Factors; D000159:Vestibulocochlear Nerve / Q000473:pathology / Q000503:physiopathology* / Q000648:ultrastructure