title: Improvement of warfarin biopharmaceutics by conjugation with poly(ethylene glycol).
abstract: One of the most used and useful polymers, poly(ethylene glycol) (PEG) was used as a carrier for warfarin. The drug-polymer conjugate was freely water soluble at room temperature. The hydrolytic stability of the PEG-warfarin was investigated at physiological pH and confirmed the stability of the conjugate. In vivo release studies demonstrated a good release of parent drug, without the initial high plasma level of warfarin.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Piazzale Europa 1, 34127 Trieste, Italy. zacchign@units.it
authors.forename: Marina
authors.initials: M
authors.lastname: Zacchigna
authors.forename: Gabriella
authors.initials: G
authors.lastname: Di Luca
authors.forename: Francesca
authors.initials: F
authors.lastname: Cateni
authors.forename: Venerando
authors.initials: V
authors.lastname: Maurich
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002138:Calibration; D004563:Electrochemistry; D007274:Injections, Intraperitoneal; D007441:Intubation, Gastrointestinal; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D011817:Rabbits; D014859:Warfarin / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D011092:Polyethylene Glycols; D014859:Warfarin