title: [Continuous and momentous tobacco abstinence with pharmacologic therapy in clinical practice].
abstract: OBJECTIVE
  The objective of the study was to evaluate the effectiveness of the pharmacological treatment of tobacco dependence according to the criteria established by SEPAR.
  
  
  METHODS
  Longitudinal, prospective and multicentre study. We included smokers aged more than 18 years who attended 5 smokers clinics and received nicotine replacement therapy (NRT), bupropion or both. The punctual and continuous abstinence was studied at the 15, 30, 60, 90 and 180 days with each one of the proposed treatments. Effective results were defined as the intention to treat.
  
  
  RESULTS
  There were 904 smokers, 476 males and 428 females, mean age 42.51 (10.09). Of the 904 individuals who started the treatment, 820, 776, 687, 719 and 679 were present at the follow-up sessions at 15, 30, 60, 90 and 180 days, respectively. The punctual global abstinence at 15 and 180 days was 65.6% and 43.1%, while the continuous one was 57.4% and 38.8% at two and six months, respectively. Significant differences were not observed with regard to the punctual or continuous abstinence among patients treated with NRT, bupropion or both.
  
  
  CONCLUSIONS
  The pharmacological treatment of tobacco dependence used individually according to the recommendations of the clinical guidelines allows to obtain good results with regard to the momentous and continuous abstinence. The effectiveness of the different first line treatments is similar in all the phases of the therapeutic process.
authors.affiliation: Hospital Universitario, Salamanca, Spain. mibafe@telefonica.net
authors.forename: Miguel
authors.initials: M
authors.lastname: Barrueco Ferrero
authors.forename: Carlos
authors.initials: C
authors.lastname: Jiménez Ruiz
authors.forename: Luis
authors.initials: L
authors.lastname: Palomo Cobos
authors.forename: Miguel
authors.initials: M
authors.lastname: Torrecilla García
authors.forename: Pedro
authors.initials: P
authors.lastname: Romero Palacios
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Riesco Miranda
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D016642:Bupropion / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009538:Nicotine / Q000627:therapeutic use*; D010349:Patient Compliance; D011446:Prospective Studies; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation / Q000379:methods*; D013997:Time Factors
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion; D009538:Nicotine