title: Ductal carcinoma in situ presenting as microcalcifications: the effect of stereotactic large-core needle biopsy on surgical therapy.
abstract: The aim of this investigation was to study the efficacy of surgical therapy in patients with non-palpable ductal carcinoma in situ (DCIS) presenting as microcalcifications diagnosed by means of stereotactic large-core needle biopsy (SCNB). This is a retrospective study with a historical control group within a 12-year period. Two groups of consecutive patients diagnosed with DCIS (1991-2002) by means of needle-localised open breast biopsy (NLBB, n=49) and SCNB (n=51) were studied. Both groups were comparable for clinical, radiological and pathological characteristics. The therapeutic interval (time from presentation to definitive of therapy) was 62-days in the SCNB group versus 32-days in the NLBB group (p<0.001). In the SCNB group fewer surgical procedures were required for completion of surgical therapy (p=0.006) and after local excision the surgical margins were more often tumour free (p=0.002). It is postulated that the need for fewer surgical procedures and the greater frequency of tumour-free margins after local excision may be attributable to SCNB.
authors.affiliation: Department of Surgery, Martini Hospital Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands. m.a.j.de.roos@chir.azg.nl
authors.forename: M A J
authors.initials: MA
authors.lastname: de Roos
authors.forename: R M
authors.initials: RM
authors.lastname: Pijnappel
authors.forename: A D
authors.initials: AD
authors.lastname: Groote
authors.forename: J
authors.initials: J
authors.lastname: de Vries
authors.forename: W J
authors.initials: WJ
authors.lastname: Post
authors.forename: P C
authors.initials: PC
authors.lastname: Baas
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000473:pathology*; D002114:Calcinosis / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies