title: COMT Val(158)Met and BDNF C(270)T polymorphisms in schizophrenia: a case-control study.
abstract: In a multicenter study involving 217 subjects of European ancestry [106 patients with schizophrenia and 111 healthy subjects], we tested the hypothesis that the catechol-O-methyl transferase (COMT) Val(158)Met and/or the brain-derived neurotrophic factor (BDNF) C(270)T gene polymorphisms are associated with schizophrenia. The COMT and BDNF genotype and their allele distribution did not differ between patients with schizophrenia and healthy comparison subjects. These results do not support the hypothesis that the COMT Val(158)Met or BDNF C(270)T gene polymorphisms are associated with liability to schizophrenia.
authors.affiliation: Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie 1, 80138 Naples, Italy. sgalderi@tin.it
authors.forename: Silvana
authors.initials: S
authors.lastname: Galderisi
authors.forename: Mario
authors.initials: M
authors.lastname: Maj
authors.forename: Brian
authors.initials: B
authors.lastname: Kirkpatrick
authors.forename: Paola
authors.initials: P
authors.lastname: Piccardi
authors.forename: Armida
authors.initials: A
authors.lastname: Mucci
authors.forename: Giordano
authors.initials: G
authors.lastname: Invernizzi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rossi
authors.forename: Stefano
authors.initials: S
authors.lastname: Pini
authors.forename: Antonio
authors.initials: A
authors.lastname: Vita
authors.forename: Paolo
authors.initials: P
authors.lastname: Cassano
authors.forename: Paolo
authors.initials: P
authors.lastname: Stratta
authors.forename: Giovanni
authors.initials: G
authors.lastname: Severino
authors.forename: Maria
authors.initials: M
authors.lastname: Del Zompo
mesh_terms: D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D008040:Genetic Linkage / Q000235:genetics; D005838:Genotype; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D009419:Nerve Tissue Proteins; D002394:Catechol O-Methyltransferase