An unusual pyridine nucleotide accumulating in erythrocytes: its identity and positive correlation with degree of renal failure.
We have investigated an unusual nucleotide that accumulates, with precursors, in the erythrocytes of patients in uraemia. This nucleotide is related chemically to the NAD breakdown product, N1-methyl-2-pyridone-5-carboxamide (Me2Py), found in high concentrations in the plasma of uraemic patients. Both Me2Py and the nucleotide accumulate to high concentrations in the blood during uraemia: our investigations of samples from renal out-patients have provided information on a plausible link between the two compounds.
Carrey
E A
EA
University College London, Institute of Child Health, London, UK. e.carrey@ich.ucl.ac.uk
Smolenski
R T
RT
Edbury
S M
SM
Laurence
A
A
Marinaki
A M
AM
Duley
J A
JA
Zhu
L M
LM
Goldsmith
D J A
DJ
Simmonds
H A
HA
D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D013058:Mass Spectrometry; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D009711:Nucleotides / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D011742:Pyrimidine Nucleotides / Q000378:metabolism; D051437:Renal Insufficiency / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D013997:Time Factors; D014466:Ultraviolet Rays; D014511:Uremia / Q000097:blood
D009711:Nucleotides; D011725:Pyridines; D011742:Pyrimidine Nucleotides; D009536:Niacinamide; C005211:N'-methyl-2-pyridone-5-carboxamide; C023666:pyridine