[Obstetrical prognosis improvement in patients exposed in utero to diethylstilbestrol with specific care management].
OBJECTIVE
To define the interest of a specific care management of pregnancies in patients exposed in utero to diethylstilbestrol, with the intention of reducing the number of spontaneous miscarriage and prematurity.


METHODS
One hundred and three pregnancies in 49 patients exposed in utero to diethylstilbestrol were followed during a 4-year study, while establishing a specific care management of pregnancies in those women.


RESULTS
Spontaneous miscarriage rate was 18.5%, among which 16.5% before 15 weeks of pregnancy and 2% after 15 weeks of pregnancy. Premature birth rate was 41.9%, among which 10.8% of great premature birth (before 32 weeks of pregnancy), 13.5% of moderate premature birth (between 32 and 36 weeks of pregnancy), and 17.6% of minor prematurity (after 36 weeks of pregnancy). The patients' average delivery term was 36 +/-3.6 weeks.


CONCLUSIONS
As compared with the literature data, our miscarriage and prematurity rates are found to be lower. Our specific care management seems thus to be effective.
Amour
M-C
MC
Service de gynécologie-obstétrique, CHI Jean-Rostand, 141, Grande-Rue, 92311 Sèvres, France. julien.amour@psl.ap-hop-paris.fr
Mokdad
A
A
Mayenga
J-M
JM
Belaisch-Allart
J
J
D000022:Abortion, Spontaneous / Q000453:epidemiology*; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology; D011297:Prenatal Exposure Delayed Effects; D011379:Prognosis
D004054:Diethylstilbestrol