title: Isolation of cytochrome P450 inhibitors from strawberry fruit, Fragaria ananassa.
abstract: A new glycoside, 2-beta-d-glucopyranosyloxy-4,6-dihydroxyisovalerophenone (3), was isolated from strawberry fruit along with kaempferol-3-beta-D-(6-O-trans-p-coumaroyl)glucopyranoside (1) and kaempferol-3-beta-D-(6-O-cis-p-coumaroyl)glucopyranoside (2). Compounds 1 and 2 inhibited activity of a drug-metabolizing enzyme, CYP3A4.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa 920-0934, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tomise
authors.forename: Maki
authors.initials: M
authors.lastname: Aburatani
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Onuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirorta
authors.forename: Eiji
authors.initials: E
authors.lastname: Ishiharajima
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Ohta
mesh_terms: D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031985:Fragaria / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: C495157:2-beta-D-glucopyranosyloxy-4,6-dihydroxyisovalerophenone; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D006027:Glycosides; D044949:Kaempferols; C495158:kaempferol-3-beta-D-(6-O-trans-p-coumaroyl)glucopyranoside; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human