title: Effects of overlapping GB virus C/hepatitis G virus synthetic peptides on biomembrane models.
abstract: The present study was undertaken to examine the physicochemical properties of three overlapping peptides belonging to the E2 envelope protein of Hepatitis G virus (GBV-C/HGV) and its interaction with phospholipid biomembrane models using biophysical techniques. We describe our findings concerning the surface activity and the interaction of the peptides with monolayers and liposomes composed of the zwitterionic phospholipids dipalmitoylphosphatidylcholine and dimyristoylphosphatidylcholine (DMPC) and a mixture of DMPC with the anionic phospholipid dimyristoylphosphatidylglycerol. The results inform about the effect of the chain length on their interaction with biomembrane models. The longest chain peptide interacts in a higher extent with all the phospholipid studied as a result of a combination of hydrophobic and electrostatic forces.
authors.affiliation: Department of Peptide Protein Chemistry and Laboratory of Thermal Analysis, IIQAB-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Larios
authors.forename: María A
authors.initials: MA
authors.lastname: Busquets
authors.forename: Josep
authors.initials: J
authors.lastname: Carilla
authors.forename: María A
authors.initials: MA
authors.lastname: Alsina
authors.forename: Isabel
authors.initials: I
authors.lastname: Haro
mesh_terms: D029407:GB virus C / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D008567:Membranes, Artificial; D008956:Models, Chemical; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*; D013499:Surface Properties; D014759:Viral Envelope Proteins / Q000737:chemistry*
chemical_list: D008081:Liposomes; D008567:Membranes, Artificial; D010446:Peptide Fragments; D010743:Phospholipids; D014759:Viral Envelope Proteins; C107619:glycoprotein E2, GB virus C