title: [Statin and BMP].
abstract: Bone morphogenetic proteins (BMP) are cytokines that promote differentiation of mesenchymal stem cells into differentiated osteoblasts and bone formation. Recently, HMG-CoA reductase inhibitors (statins) emerged as a candidate for the treatment of osteoporosis, because they stimulate BMP-2 expression and bone formation. Inhibition of Rho/Rho-kinase pathway may be involved in statin effect on bone formation.
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyusyu University.
authors.forename: Keizo
authors.initials: K
authors.lastname: Ohnaka
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
mesh_terms: D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D019485:Bone Morphogenetic Proteins; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors