title: Chronic hepatitis in Doberman pinschers. A review.
abstract: Chronic hepatitis in Doberman pinschers is predominantly seen in female dogs, usually between 4 and 7 years of age and was first recognized in the early eighties. The histopathological characteristics of Doberman hepatitis are those of micronodular cirrhosis with histological features of fibrosis, piece meal necrosis and progressive lymphocyte and plasma cell infiltration of the portal triads. Currently there are two hypotheses on the pathogenesis although neither of them has been elucidated. The first hypothesis is that of a copper toxicosis. The second is that of autoimmunity. Similarities and differences with other breeds and studies on both hypotheses are reviewed, as well as results of recent research of our group. Based on recent findings chronic hepatitis in Doberman pinschers is most likely to be a form of copper toxicosis. Although there are several indications that suggest autoimmunity as well, this still remains unclear.
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands. p.j.j.mandigers@vet.uu.nl
authors.forename: P J J
authors.initials: PJ
authors.lastname: Mandigers
authors.forename: T S G A M
authors.initials: TS
authors.lastname: van den Ingh
authors.forename: B
authors.initials: B
authors.lastname: Spee
authors.forename: L C
authors.initials: LC
authors.lastname: Penning
authors.forename: P
authors.initials: P
authors.lastname: Bode
authors.forename: J
authors.initials: J
authors.lastname: Rothuizen
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000662:veterinary; D001947:Breeding; D003300:Copper / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000502:physiology; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D004285:Dogs; D005260:Female; D006520:Hepatitis, Animal / Q000209:etiology / Q000473:pathology*; D006521:Hepatitis, Chronic / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D008297:Male; D012737:Sex Factors
chemical_list: D003300:Copper