title: [Comparative evaluation of therapeutic effects of 3 and 4 antitubercular agents at the initial stage of the treatment of renal tuberculosis].
abstract: Three groups of the parameters of the therapeutic effects of 3 and 4 antituberculous drugs on renal tuberculous inflammation were identified. The primary effect of 4 drugs was much frequently manifested itself by the normalization of urinalysis and the transfer of cultured to uncultured Mycobacterium tuberculosis (MBT). The equivalent effect of 3 and 4 drugs was characterized by the similar rate of continuation of specific mycobacteriuria, by the detection of MBT in the cavernous contents from the removed tuberculosis-afflicted kidney and by the equivalent morphological characteristics of tuberculous inflammation involution. The negative impact of the therapeutic action of 4-component chemotherapy appeared as a much larger number of cases of intolerance of antituberculous drugs, hepatic and renal failures, and toxic-and-allergic reactions.
authors.forename: I S
authors.initials: IS
authors.lastname: Kamyshan
authors.forename: L P
authors.initials: LP
authors.lastname: Pavlova
authors.forename: A N
authors.initials: AN
authors.lastname: Mams
authors.forename: N A
authors.initials: NA
authors.lastname: Saĭdakova
authors.forename: P I
authors.initials: PI
authors.lastname: Stepanov
mesh_terms: D000995:Antitubercular Agents / Q000145:classification* / Q000627:therapeutic use*; D006801:Humans; D014398:Tuberculosis, Renal / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents