Suppressive effect of antibiotic siomycin on antibody production.
The antibiotic thiazole compound siomycin, which we have found from the culture broth of Actinomycetes (strain No.806097) in search of antibody production inhibitor, showed the in vitro immunosuppressive property against B-cells stimulated with T-cell independent antigen DNP-LPS (dinitrophenyl-lipopolysaccharide) while it also showed inhibitory effect against T-cell proliferation. Its inhibitory mechanism was considered to be different from that of FK506, the representative of T-cell immunosuppressant. Moreover, siomycin showed inhibitory effect in both T-cell dependent and independent murine antibody production models and decreased the severity in murine collagen arthritis model. Therefore, siomycin is a unique immunosuppressant which has potential for the treatment of some antibody-mediated diseases.
Ueno
Motoi
M
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. motoi_ueno@po.fujisawa.co.jp
Furukawa
Satoko
S
Abe
Fumie
F
Ushioda
Michiko
M
Fujine
Kiyotaka
K
Johki
Shigeru
S
Hatori
Hidetaka
H
Ueda
Hirotsugu
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000917:Antibody Formation / Q000187:drug effects*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D001402:B-Lymphocytes / Q000276:immunology; D003094:Collagen; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D010455:Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology; D016559:Tacrolimus / Q000494:pharmacology / Q000627:therapeutic use; D013883:Thiostrepton / Q000494:pharmacology / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D010455:Peptides; C025311:siomycin; D003094:Collagen; D013883:Thiostrepton; D016559:Tacrolimus