[Radioprotective efficacy of chitosan, dissolved in aqueous extract of Abies Sibirica].
In experiments on rats it has been shown, that radioprotective efficacy of water-soluble low-molecular chitosan (MM 23 kDa) used in a dose 5 mg/kg (per os 5 ml/kg, daily ten-day treatment after whole-body irradiation with LD90/30) is higher, when it is dissolved in Abisib (aqueous extract of Abies Sibirica fir-needles) in comparison with chitosan dissolved in distilled water. Survival rate and average life significantly increase. Radioprotective efficacy of water-soluble low-molecular chitosan in a dose 5 mg/kg dissolved in distilled water or in Abisib (Chitabis) has been estimated. In comparison with control rats exposed to LD90/30, Chitabis administration (per os 5 ml/kg, daily ten-day treatment) leads to increase of average life from 15.44 +/- 2.31 to 28.37 +/- 3.09 days and of survival rate from 9.75 +/- 7.75% to 34.0 +/- 3.6%.
Gulik
E S
ES
Kostesha
N Ia
NIa
D028202:Abies / Q000737:chemistry*; D000818:Animals; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D012996:Solutions; D014867:Water
D010936:Plant Extracts; D011837:Radiation-Protective Agents; D012996:Solutions; D014867:Water