title: Preparation of cyclic peptide libraries using intramolecular oxime formation.
abstract: A new method for the synthesis of cyclic head-to-side chain peptide libraries has been developed in which the key cyclization step involves reaction between a C-terminal ketone and an N-terminal hydroxylamine to form a macrocyclic oxime. This methodology efficiently delivers cyclic products that consist of mixtures of syn and anti isomers.
authors.affiliation: School of Chemistry, The University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia. kade.roberts@ludwig.edu.au
authors.forename: Kade D
authors.initials: KD
authors.lastname: Roberts
authors.forename: John N
authors.initials: JN
authors.lastname: Lambert
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Ede
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Bray
mesh_terms: D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D010091:Oximes / Q000737:chemistry; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000138:chemical synthesis*
chemical_list: D010091:Oximes; D019151:Peptide Library; D010456:Peptides, Cyclic