title: Erythema marginatum and hereditary angioedema.
abstract: OBJECTIVE
  To search for anaphylatoxin activity in plasma during episodes of erythema marginatum, and to evaluate the histology of erythema marginatum by electron microscopy and immunohistologic techniques.
  
  
  METHODS
  Plasma samples were studied for C5a activity by granulocyte aggregation, and C3 conversion by immunoelectrophoresis. A skin biopsy of erythema marginatum was done, and the tissue stained with a rabbit antibody to bradykinin.
  
  
  RESULTS
  No plasma anaphylatoxin was found. Dense deposits of bradykinin were discovered in stromal tissue and lining endothelial cells.
  
  
  CONCLUSIONS
  Bradykinin may be important in the causality of the erythema marginatum associated with hereditary angioedema.
authors.affiliation: Division of Allergy & Immunology, Department of Pathology, Scott & White, Scott, Sherwood, TX, USA. jstarr@swmail.sw.org
authors.forename: John C
authors.initials: JC
authors.lastname: Starr
authors.forename: George W
authors.initials: GW
authors.lastname: Brasher
authors.forename: Arundhati
authors.initials: A
authors.lastname: Rao
authors.forename: Delma
authors.initials: D
authors.lastname: Posey
mesh_terms: D000328:Adult; D000706:Anaphylatoxins / Q000378:metabolism*; D000799:Angioedema / Q000209:etiology* / Q000235:genetics; D001920:Bradykinin / Q000009:adverse effects* / Q000276:immunology / Q000302:isolation & purification; D004890:Erythema / Q000097:blood* / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000706:Anaphylatoxins; D001920:Bradykinin