Novel thiocyanato complexes with potent cytotoxic and antimicrobial properties.
The aim of the present study was to assess the cytotoxic and antimicrobial properties of seven new thiocyanato complexes: Ni(C(9)H(11)N(2)O)(SCN), Cu(C(9)H(11)N(2)O)(SCN), Pd(C(9)H(11)N(2)O)(SCN), Pt(C(9)H(11)N(2) O) (SCN), K[Ti(C(9)H(11)N(2)O)(SCN)(3)], Au(C(9)H(11)N(2)O)(SCN), and K[V(O)(C(9)H(11)N(2)O)(SCN)] (T(1)-T(7), respectively). All the complexes showed toxicity against brine shrimp nauplii (Artemia salina L.). The titanium-based complex, T(5), exhibited potent toxicity, with a lethal concentration 50% (the concentration of test compound that kills 50% of A. salina) value of 1.59 microg mL(-1). These new complexes also exhibited promising antibacterial and antifungal properties. A macrodilution technique was used to estimate the minimum inhibitory concentrations of the seven bioactive complexes. Minimum inhibitory concentrations were found to be 8-64 microg mL(-1) against the tested bacterial species.
Hossain
M Shamim
MS
Pharmacology and Molecular Biology Laboratory, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh.
Easmin
Sabina
S
Islam
M Saidul
MS
Rashid
Mamunur
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000633:toxicity*; D000935:Antifungal Agents / Q000737:chemistry* / Q000633:toxicity*; D001156:Artemia / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D013861:Thiocyanates / Q000737:chemistry* / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013861:Thiocyanates; C031760:thiocyanate