Detection of gliotoxin in experimental and human aspergillosis.
Gliotoxin was measured in the lungs (mean, 3,976 +/- 1,662 ng/g of tissue) and sera (mean, 36.5 +/- 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.
Lewis
Russell E
RE
University of Houston College of Pharmacy; 1441 Moursund St. #423, Houston, TX 77030, USA. rlewis@uh.edu
Wiederhold
Nathan P
NP
Chi
Jingduan
J
Han
Xiang Y
XY
Komanduri
Krishna V
KV
Kontoyiannis
Dimitrios P
DP
Prince
Randall A
RA
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005912:Gliotoxin / Q000032:analysis*; D006801:Humans; D008168:Lung / Q000737:chemistry; D051379:Mice
D005912:Gliotoxin; D000666:Amphotericin B