title: Secondary male factor infertility after Roux-en-Y gastric bypass for morbid obesity: case report.
abstract: Surgical treatments such as the Roux-en-Y gastric bypass operation result in the successful treatment of morbid obesity; however, this type of operation may cause long-term side effects due to the reduced absorption of nutrients. Here, we present data suggesting that this operation can result in secondary infertility in males. Six healthy, previously fertile male subjects presented in our centre for secondary infertility after a Roux-en-Y gastric bypass operation for morbid obesity. Reproductive function was assessed with a series of spermiograms, and by testicular biopsy. Secondary azoospermy with complete spermatogenic arrest was diagnosed. The results suggest that weight reduction surgery may cause reproductive dysfunction.
authors.affiliation: Centre for Reproductive Biology, Clinica Villa del Sole, Via Manzoni, 15, 80126 Naples, Italy.
authors.forename: Antonio Scotto
authors.initials: AS
authors.lastname: di Frega
authors.forename: Brian
authors.initials: B
authors.lastname: Dale
authors.forename: Loredana
authors.initials: L
authors.lastname: Di Matteo
authors.forename: Martin
authors.initials: M
authors.lastname: Wilding
mesh_terms: D000328:Adult; D000713:Anastomosis, Roux-en-Y / Q000009:adverse effects*; D015390:Gastric Bypass / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007248:Infertility, Male / Q000209:etiology*; D008286:Malabsorption Syndromes / Q000150:complications / Q000209:etiology; D008297:Male; D009767:Obesity, Morbid / Q000601:surgery*; D013091:Spermatogenesis