Disseminated tuberculosis complicating anti-TNF-alpha treatment.
An unusually large number of cases of tuberculosis, often of miliary or disseminated form, have been reported in patients receiving infliximab therapy for rheumatoid arthritis or Crohn's disease. We describe a patient with rheumatoid arthritis who was treated with infliximab and became systemically ill with Mycobacterium tuberculosis-disseminated infection. Patients who are candidates for treatment with tumour necrosis factor-alfa inhibitors should be evaluated for the presence of latent or active
Dimakou
K
K
Department of Respiratory Medicine, University of Athens Medical School, Sotiria Hospital, Athens, Greece.
Papaioannides
D
D
Latsi
P
P
Katsimboula
S
S
Korantzopoulos
P
P
Orphanidou
D
D
D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D000075202:Contraindications; D005260:Female; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014391:Tuberculosis, Miliary / Q000150:complications* / Q000000981:diagnostic imaging; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000000981:diagnostic imaging; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab