Negative regulation of T-cell function by PD-1.
PD-1 is a receptor inducibly expressed on CD4+ and CD8+ T cells following activation. PD-1-deficient mice develop signs of autoimmunity, suggesting a negative regulatory role for PD-1 in dampening lymphocyte responses. The expression of one ligand for PD-1, designated PD-L1 or B7-H1, on tumor cells of a variety of histologies has suggested a potential mechanism for tumor escape from immune destruction. This review summarizes data regarding PD-1 and related negative regulatory receptors, focusing on implications for potentiating antitumor immunity in vivo.
Zha
Yuan yuan
Yy
University of Chicago, Department of Pathology, Section of Hematology/Oncology, Chicago, IL 60637, USA.
Blank
Christian
C
Gajewski
Thomas F
TF
D000818:Animals; D015703:Antigens, CD; D000954:Antigens, Surface / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D051017:Apoptosis Regulatory Proteins; D015551:Autoimmunity / Q000276:immunology; D018122:B7-1 Antigen / Q000235:genetics / Q000276:immunology; D060890:B7-H1 Antigen; D015870:Gene Expression / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D036341:Intercellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology; D010455:Peptides / Q000235:genetics / Q000276:immunology; D061027:Programmed Cell Death 1 Ligand 2 Protein; D061026:Programmed Cell Death 1 Receptor; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014181:Transplantation Immunology / Q000276:immunology
D015703:Antigens, CD; D000954:Antigens, Surface; D051017:Apoptosis Regulatory Proteins; D018122:B7-1 Antigen; D060890:B7-H1 Antigen; C423236:CD274 protein, human; C498919:Cd274 protein, mouse; D036341:Intercellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; C105992:PDCD1 protein, human; C556977:PDCD1LG2 protein, human; C491383:Pdcd1 protein, mouse; C556978:Pdcd1lg2 protein, mouse; D010455:Peptides; D061027:Programmed Cell Death 1 Ligand 2 Protein; D061026:Programmed Cell Death 1 Receptor; D011971:Receptors, Immunologic