[Association of cytochrome P450 gene MSP1 polymorphism and risk of preterm].
OBJECTIVE
To investigate the association of cytochrome p450 gene (CYP1A1)MSP1 polymorphisms with preterm delivery.


METHODS
Between July 1999 and June 2001, we conducted a case-control study using infant-parent triads including 247 families with full-term infants and 249 families with preterm delivery infants in Anqing, China. We extracted DNA from umbilical cord blood of the infants and vein blood of their parents,and performed PCR followed by restriction enzyme MspI digestion for genotyping the CYP1A1 gene MSP1 polymorphism. We used log-linear modeling to analyze the association of CYP1A1 gene polymorphism with the risk of preterm delivery.


RESULTS
CYP1A1 gene C/C6235 increased the risk of preterm delivery both in infants (RR=1.80, 95% CI=1.02-3.18) and in their mothers (RR=1.82, 95% CI=1.11-2.98) significantly. There was no interaction between mothers' and children's CYP1A1 MSP1 genotypes. The variant alleles of CYP1A1 MSP1 of control triads accorded with Mendelian transmissions.


CONCLUSIONS
Both infant and maternal CYP1A1 C/C6235 genotype both can increase the risk of preterm delivery in our study population, which suggests a possible role of human cytochrome P450 variability in the etiology of preterm delivery.
Jin
Ying
Y
Peking University Stem Cell Research Center, Beijing 100083, China.
Chen
Da-fang
DF
Yang
Fan
F
Li
Zhi-ping
ZP
Fang
Zhi-an
ZA
Li
Ling-song
LS
Wang
Li-hua
LH
D000328:Adult; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004247:DNA / Q000235:genetics / Q000378:metabolism; D019003:Deoxyribonuclease HpaII / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D020066:Merozoite Surface Protein 1; D007752:Obstetric Labor, Premature / Q000235:genetics*; D017354:Point Mutation; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012307:Risk Factors
D020066:Merozoite Surface Protein 1; D004247:DNA; D019363:Cytochrome P-450 CYP1A1; D019003:Deoxyribonuclease HpaII