[Multiple extrahepatic manifestations in a patient with chronic hepatitis C treated with interferon-alfa].
The case of a 61-years-old female patient with chronic hepatitis C who developed multiple consecutive extrahepatic manifestations is reported. One of these manifestations (lichen planus) appeared before HCV-related chronic hepatitis was diagnosed and treated with interferon-alpha, suggesting that it was likely associated with HCV itself. Other manifestations appeared during IFN-alpha treatment (polyarthritis) or after the end of treatment (ulcerative cholitis, sarcoidosis) implying a role for either HCV or IFN-alpha treatment in the pathogenesis of extrahepatic manifestations.
Napoli
Nicola
N
Dipartimento di Clinica Medica, Immunologia e Malattie Infettive, Sezione di Medicina Interna, Università, Bari. n.napoli@intmed.uniba.it
Tortorella
Cosimo
C
Deramo
Maria Teresa
MT
Antonaci
Alessandra
A
Parisi
Carmen Vita
CV
Antonaci
Salvatore
S
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D001168:Arthritis / Q000139:chemically induced / Q000209:etiology*; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use*; D008010:Lichen Planus / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D017565:Sarcoidosis, Pulmonary / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D016898:Interferon-alpha; D011241:Prednisone