Ginsenoside-Rd from Panax notoginseng enhances astrocyte differentiation from neural stem cells.
Neural stem cells cultured as neurospheres were used to assess the effects of P. notoginseng on the production of neurons and glia. The crude saponins (PNS) and ginsenoside-Rd promote the differentiation of neurospheres into astrocytes. Ginsenoside-Rd increases the production of astrocytes in a dose-dependent manner. On the other hand, both PNS and ginsenoside-Rd induce a weak but significant effect by decreasing the number of neurons. The other ginsenosides do not induce any differentiation on both neurons and astrocytes.
Shi
Qin
Q
Laboratoire de Chimie Organique des Substances Naturelles, UMR CNRS-ULP 7123, 5 rue Blaise Pascal 67084 Strasbourg, France.
Hao
Qi
Q
Bouissac
Julien
J
Lu
Yang
Y
Tian
Songjiu
S
Luu
Bang
B
D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D036145:Ginsenosides / Q000494:pharmacology*; D051379:Mice; D009474:Neurons / Q000166:cytology*; D005894:Panax / Q000737:chemistry; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects*
D036145:Ginsenosides; C049863:ginsenoside Rd