How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?
Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication.
Fischhaber
Paula L
PL
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9072, USA. paula.fischhaber@utsouthwestern.edu
Friedberg
Errol C
EC
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D004259:DNA-Directed DNA Polymerase / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology; D006801:Humans; D025842:SUMO-1 Protein / Q000502:physiology; D025801:Ubiquitin / Q000502:physiology
D025842:SUMO-1 Protein; D025801:Ubiquitin; D004259:DNA-Directed DNA Polymerase