[Growth factors and wound healing: review and prospect in recent ten years].
OBJECTIVE
To review the current condition of growth factors and their application to clinical treatment of acute and chronic wounds.


METHODS
Data from the literature and Medline were analyzed according to their different uses in acute and chronic wounds. Their potential side-effects were studied.


RESULTS
All data showed that wound healing time in acute and chronic wounds was accelerated and wound healing quality was improved after treatment with growth factors. No side-effect was observed.


CONCLUSIONS
The efficacy and safety of growth factors in improving wound healing were confirmed. However, some reconsideration about potential problems of growth factors must be made to apply them clinically in the future.
Fu
Xiaobing
X
Key Research Laboratory of Wound Repair of PLA, 304th Clinical Department, General Hospital of PLA, Beijing. fuxb@cgw.net.cn
Cheng
Biao
B
Sheng
Zhiyong
Z
D000818:Animals; D002056:Burns / Q000628:therapy*; D004815:Epidermal Growth Factor / Q000627:therapeutic use; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use; D006133:Growth Substances / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use; D012867:Skin / Q000293:injuries; D017695:Soft Tissue Injuries / Q000628:therapy*; D016212:Transforming Growth Factor beta / Q000627:therapeutic use; D042461:Vascular Endothelial Growth Factor A / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
D006133:Growth Substances; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D004815:Epidermal Growth Factor