Tandem intramolecular Nicholas and Pauson-Khand reactions for the synthesis of tricyclic oxygen-containing heterocycles.
[reaction: see text] Simple acyclic enynes can be easily converted into tricyclic ethers upon treatment with Co2(CO)8 followed by Nicholas and Pauson-Khand reactions. Tricyclic [5,8,5]- and [5,7,5]-systems can be prepared in high overall yields in only seven synthetic steps.
Quintal
Miriam M
MM
Department of Chemistry, Smith College, Northampton, Massachusetts 01063, USA.
Closser
Kristina D
KD
Shea
Kevin M
KM