title: The prognosis of women with stage IB1-IIB node-positive cervical carcinoma after radical surgery.
abstract: BACKGROUND
  Pelvic lymph nodes metastasis is an important prognostic factor for patients with cervical carcinoma. However, the relationships between the number of positive nodes, site of metastases nodes, adjuvant therapy and the prognosis is controversial. The purpose of this study was to investigate the influence of positive lymph nodes on the prognosis of Chinese women with stage IB1-IIB cervical carcinoma.
  
  
  METHODS
  Between January 1992 and December 1997, 398 women with International Federation of Gynecology and Obstetrics (FIGO) stage IB1-IIB cervical carcinoma underwent radical surgery in Cancer Hospital, Fudan University. Of these sixty-six patients (16.6%) who were histologically confirmed to have positive pelvic lymph nodes were analyzed retrospectively. The survival was estimated using Kaplan-Meier method. The differences in survival were compared with Log-rank test. Multivariate analyses were performed with the Cox proportional hazard model.
  
  
  RESULTS
  The 5-year survival of the patients with pelvic lymph nodes metastases was 40.7%. Cox proportional hazard model analysis showed that cellular differentiation, the number of positive nodes and adjuvant therapy to be the independent prognostic factors (P < 0.05). The 5-year survival of patients with one positive node was higher than that of those with two or more positive nodes (56.5% vs. 36.4%, P < 0.05). The distant metastasis rate in the former group (5.9%) was lower than the latter's (32.7%) (P = 0.05). However, there was no significant difference of pelvic recurrence between the two groups (P > 0.05). The number of positive nodes positively correlated with the level of positive nodes (P < 0.01). The 5-year survival of the patients who had no adjuvant therapy (12.6%) was much lower than that (53.7%) of those with adjuvant therapy (P < 0.05). However, there was no obvious difference between adjuvant radiotherapy, chemotherapy and chemo-radiotherapy (P > 0.05).
  
  
  CONCLUSIONS
  The prognosis of patients with stage IB1-IIB node-positive cervical carcinoma who underwent radical surgery alone was very poor. Adjuvant therapy increases the survival rate, decreases the pelvic recurrence and distant metastasis.
authors.affiliation: Department of Gynecologic Oncology, Cancer Hospital, Fudan University, Shanghai, 200032, PR China. cheng_xi1@hotmail.com
authors.forename: Xi
authors.initials: X
authors.lastname: Cheng
authors.forename: Shumo
authors.initials: S
authors.lastname: Cai
authors.forename: Ziting
authors.initials: Z
authors.lastname: Li
authors.forename: Meiqin
authors.initials: M
authors.lastname: Tang
authors.forename: Muquan
authors.initials: M
authors.lastname: Xue
authors.forename: Rongyu
authors.initials: R
authors.lastname: Zang