title: Azoospermia in testicular sarcoidosis is an indication for corticosteroid therapy.
abstract: OBJECTIVE
  To report improvement of azoospermia and hypogonadism after high-dose corticosteroid therapy in a patient with testicular sarcoidosis.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A 27-year-old man with testicular sarcoidosis and azoospermia.
  
  
  METHODS
  High-dose corticosteroid therapy was commenced in an attempt to improve sperm count and restore gonadal function.
  
  
  METHODS
  Analysis of sperm count, T, and gonadotropin response to steroid therapy.
  
  
  RESULTS
  FSH and LH concentrations decreased and T levels increased in parallel with control of disease activity with steroid therapy. Repeat semen analysis demonstrated a significant increase in sperm count, allowing sperm banking to take place.
  
  
  CONCLUSIONS
  High-dose corticosteroid therapy may be indicated in testicular sarcoidosis, not only for control of systemic disease activity but also for recovery of gonadal function and spermatogenesis.
authors.affiliation: Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom. reesda@cf.ac.uk
authors.forename: D Aled
authors.initials: DA
authors.lastname: Rees
authors.forename: Alex L
authors.initials: AL
authors.lastname: Dodds
authors.forename: Nia
authors.initials: N
authors.lastname: Rathbone
authors.forename: J Stephen
authors.initials: JS
authors.lastname: Davies
authors.forename: Maurice F
authors.initials: MF
authors.lastname: Scanlon
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009845:Oligospermia / Q000209:etiology*; D012507:Sarcoidosis / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D013076:Sperm Count; D013091:Spermatogenesis / Q000187:drug effects; D013733:Testicular Diseases / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000305:Adrenal Cortex Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone