The 9cis,11trans,13cis isomer of conjugated linolenic acid reduces apolipoprotein B100 secretion and triacylglycerol synthesis in HepG2 cells.
The physiological effects of 9cis,11trans,13cis-conjugated linolenic acid (9c,11t,13c-CLNA), one of the CLNA isomers, were studied in human hepatoma HepG2 cells. 9c,11t,13c-CLNA significantly decreased apolipoprotein B100 secretion compared with alpha-linolenic acid (alpha-LNA). The uptake of (14)C-oleate into newly synthesized cellular triacylglycerol was also decreased by 9c,11t,13c-CLNA more than by alpha-LNA treatment. This is the first study to show the hypolipidemic effect of 9c,11t,13c-CLNA.
Arao
Keisuke
K
Department of Applied Biological Sciences, Saga University, Honjyo-1, Saga 840-8502, Japan.
Yotsumoto
Hiroaki
H
Han
Seo-Young
SY
Nagao
Koji
K
Yanagita
Teruyoshi
T
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000378:metabolism*; D045744:Cell Line, Tumor; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology; D044243:Linoleic Acids, Conjugated / Q000737:chemistry / Q000494:pharmacology*; D019301:Oleic Acid / Q000378:metabolism; D014280:Triglycerides / Q000096:biosynthesis*
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D000960:Hypolipidemic Agents; D044243:Linoleic Acids, Conjugated; D014280:Triglycerides; D019301:Oleic Acid