[Relation of genetic polymorphism of XRCC1 with risks of chronic benzene poisoning].
OBJECTIVE
To explore the relation between genetic polymorphisms in XRCC1 and risks of chronic benzene poisoning (BP).


METHODS
A case-control study was conducted. 152 BP patients and 152 workers occupationally exposed to benzene without poisoning manifestations were investigated. PCR-RFLP was applied to detect the single nucleotide polymorphisms (SNPs) on c.194, c.280 and c.399 of XRCC1 gene.


RESULTS
The proportion of XRCC1 c.194Arg/Trp + Trp/Trp genotypes in the case group was lower than that of the control group, while there was a higher proportion for XRCC1 C.280Arg/His + His/His in the case group. There was a 1.67-fold decreased risk of BP for individuals carrying XRCC1 C.194Arg/Trp + Trp/Trp genotypes (OR adj = 0.60, 95% CI: 0.37-0.97, P = 0.039) compared with subjects carrying Arg/Arg allele, and individuals carrying genotypes of XRCC1 C.280Arg/His + His/His had a 1.91-fold increased risk of BP compared with these carrying the wild allele (OR adj = 1.91, 95% CI: 1.17-3.10, P = 0.009).


CONCLUSIONS
The risk of BP for subjects carrying XRCC1 c.194Arg/Trp + Trp/Trp genotypes may decrease while for individuals carrying XRCC1 c.280Arg/His + His/His genotypes may increase.
Zhang
Zhongbin
Z
School of Public Health, Fudan University, Shanghai 200032, China.
Cao
Duozhi
D
Wan
Junxiang
J
Gu
Shouyong
S
Jin
Xipeng
X
Xia
Zhaolin
Z
D000328:Adult; D001554:Benzene / Q000506:poisoning*; D016022:Case-Control Studies; D002908:Chronic Disease; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D000076105:X-ray Repair Cross Complementing Protein 1
D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D001554:Benzene