title: Steroid-responsive encephalopathy associated with autoimmune thyroiditis and primary CNS demyelination.
abstract: Steroid responsive encephalopathy associated with autoimmune thyroiditis is a well-recognized complication of autoimmune thyroid disease. However, the characterization of the histopathological features of steroid responsive encephalopathy associated with autoimmune thyroiditis are limited to six cases. Reported pathological features include vasculitis involving venules and arterioles, lymphocytic perivascular cuffs and microglial activation. We report a case of SREAT with biopsy proven (on two occasions) primary CNS demyelination and radiological evidence of steroid responsiveness, identifying primary CNS demyelination as a complication of autoimmune thyroid disease.
authors.affiliation: Department of Neurosciences, Mail Code NC30, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Don J
authors.initials: DJ
authors.lastname: Mahad
authors.forename: Susan
authors.initials: S
authors.lastname: Staugaitis
authors.forename: Paul
authors.initials: P
authors.lastname: Ruggieri
authors.forename: Joseph
authors.initials: J
authors.lastname: Parisi
authors.forename: B K
authors.initials: BK
authors.lastname: Kleinschmidt-Demasters
authors.forename: Hans
authors.initials: H
authors.lastname: Lassmann
authors.forename: Richard M
authors.initials: RM
authors.lastname: Ransohoff
mesh_terms: D000328:Adult; D002490:Central Nervous System / Q000473:pathology / Q000503:physiopathology; D003711:Demyelinating Diseases / Q000150:complications* / Q000473:pathology; D004660:Encephalitis / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D013256:Steroids / Q000627:therapeutic use; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000473:pathology
chemical_list: D013256:Steroids