title: Central nitric oxide synthase inhibition disrupts maternal behavior in the rat.
abstract: Blocking nitric oxide (NO) production, by 3rd ventricle administration of a nitric oxide synthase (NOS) inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME; 250 microg/5 microl, postpartum [pp]) decreased milk ejections in Day 10 pp rats. On Day 4 pp, L-NAME treatment eliminated pup retrieval and at both stages of lactation suppressed maternal aggression. Fewer rats treated with L-NAME on Day 10 pp retrieved 4-day-old pups than controls, although all nursed older litters. Following exposure to a mobile intruder, Fos expression was lower in the medial preoptic area and the bed nucleus of the stria terminalis in L-NAME-treated rats than in controls but was lower in the medial amygdala only following exposure to an anaesthetized intruder. Thus, the elevated levels of NO observed in lactation may contribute to the mechanism(s) that mediate maternal behavior and aggression.
authors.affiliation: Department of Psychology, Concordia University, Montreal, Quebec, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Popeski
authors.forename: B
authors.initials: B
authors.lastname: Woodside
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D002452:Cell Count / Q000379:methods; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D007150:Immunohistochemistry / Q000379:methods; D007270:Injections, Intra-Articular / Q000379:methods; D007774:Lactation / Q000187:drug effects; D008297:Male; D008425:Maternal Behavior / Q000502:physiology*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D016761:Oncogene Proteins v-fos / Q000378:metabolism; D011301:Preoptic Area / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012686:Septal Nuclei / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
chemical_list: D004791:Enzyme Inhibitors; D016761:Oncogene Proteins v-fos; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester