Human leukocyte antigens B8-DRB1*03 in pediatric patients with nephropathia epidemica caused by Puumala hantavirus.
In adults, HLA haplotype B8-DRB1*03 is clearly associated with a severe clinical course of nephropathia epidemica caused by Puumala hantavirus. We investigated whether the same applies in pediatric patients. This HLA haplotype was found in 20 of 39 (51%) of the patients, a significantly higher figure than in the Finnish population (19%). There were, however, no significant differences in the clinical picture between patients with and without HLA B8-DRB1*03.
Mustonen
Jukka
J
Medical School, University of Tampere,Tampere University Hospital, Tampere, Finland.
Huttunen
Niilo-Pekka
NP
Partanen
Jukka
J
Baer
Maija
M
Paakkala
Antti
A
Vapalahti
Olli
O
Uhari
Matti
M
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D015795:HLA-B8 Antigen / Q000235:genetics* / Q000276:immunology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000276:immunology*; D006801:Humans; D008297:Male; D029262:Puumala virus / Q000276:immunology*
D015795:HLA-B8 Antigen