title: Metagrowth: a new resource for the building of metabolic hypotheses in microbiology.
abstract: Metagrowth is a new type of knowledge base developed to guide the experimental studies of culture conditions of obligate parasitic bacteria. We have gathered biological evidences giving possible clues to the development of the axenic (i.e. 'cell-free') growth of obligate parasites from various sources including published literature, genomic sequence information, metabolic databases and transporter databases. The database entries are composed of those evidences and specific hypotheses derived from them. Currently, 200 entries are available for Rickettsia prowazekii, Rickettsia conorii, Tropheryma whipplei, Treponema pallidum, Mycobacterium tuberculosis and Coxiella burnetii. The web interface of Metagrowth helps users to design new axenic culture media eventually suitable for those bacteria. Metagrowth is accessible at http://igs-server.cnrs-mrs.fr/axenic/.
authors.affiliation: Information Génomique et Structurale, CNRS UPR 2589, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France. Hiroyuki.Ogata@igs.cnrs-mrs.fr
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ogata
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Claverie
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D002474:Cell-Free System; D003470:Culture Media; D016208:Databases, Factual; D016680:Genome, Bacterial; D020407:Internet; D008954:Models, Biological; D014584:User-Computer Interface
chemical_list: D003470:Culture Media