title: Novel nonsynonymous polymorphisms of the CYP1A1 gene in Japanese.
abstract: We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile(448)Asn, Arg(464)Cys, and Arg(477)Trp and Pro(492)Arg, respectively) were as follows:SNP, 030212Saito001; GENE NAME, CYP1A1; ACCESSION NUMBER, X02612; LENGTH, 25 base; 5'-GTCAACCCATCT-/TGAGTTCCTACCT-3'.SNP, 030212Saito002; GENE NAME, CYP1A1; ACCESSION NUMBER, X02612; LENGTH, 25 base; 5'-GTGAGAAGGTGAT/ATATCTTTGGCAT-3'.SNP, 030212Saito003; GENE NAME, CYP1A1; ACCESSION NUMBER, X02612; LENGTH, 25 base; 5'-GAGACCGTTGCCC/TGCTGGGAGGTCT-3'.SNP, 030212Saito004; GENE NAME, CYP1A1; ACCESSION NUMBER, X02612; LENGTH, 25 base; 5'-ATCCTGCTGCAAC/TGGGTGGAATTCA-3'.SNP, 030212Saito005; GENE NAME, CYP1A1; ACCESSION NUMBER, X02612; LENGTH, 25 base; 5'-TGGACATGACCCC/GCATCTATGGGCT-3'.
authors.affiliation: Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. tetsu@pharm.hokudai.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Saito
authors.forename: Mari
authors.initials: M
authors.lastname: Egashira
authors.forename: Kazuma
authors.initials: K
authors.lastname: Kiyotani
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujieda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Chikako
authors.initials: C
authors.lastname: Kiyohara
authors.forename: Hideo
authors.initials: H
authors.lastname: Kunitoh
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kamataki