Interactions of Toll-like receptors with fungi.
The role of Toll-like receptors (TLRs) in signaling immune responses to fungal pathogens is reviewed. TLR2 and TLR4, acting via the adapter protein MyD88, signal responses to Cryptococcus neoformans, Aspergillus fumigatus and Candida albicans in vitro, although the relative significance of these TLRs to host defenses in vivo is unclear.
Levitz
Stuart M
SM
Evans Memorial Department of Medicine, Boston Medical Center, Boston University School of Medicine, Room X626, 650 Albany Street, Boston, MA 02118, USA. slevitz@bu.edu
D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*; D018950:Lipopolysaccharide Receptors / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors; D015054:Zymosan
D000943:Antigens, Differentiation; D018950:Lipopolysaccharide Receptors; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors; D015054:Zymosan