Nucleolus in the spotlight.
The recent contributions on chromatid segregation at the metaphase/anaphase transition demonstrate two distinct pathways in budding yeast. While segregation of most of the genome is a direct consequence of cohesin cleavage by separase, rDNA segregation requires a novel pathway involving Cdc14 phosphatase activation. This activation induces targeting of condensin to rDNA which in association with Aurora B kinase modulates rDNA compaction during anaphase. The resolution of rDNA sequences occurs after this step.
Hernandez-Verdun
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Nuclei and Cell Cycle Laboratory, Institut Jacques Monod, CNRS, University Paris VI and Paris VII, Paris, France. dhernand@ccr.jussieu.fr
D000705:Anaphase / Q000502:physiology; D064127:Aurora Kinases; D018797:Cell Cycle Proteins / Q000502:physiology; D002455:Cell Division / Q000502:physiology*; D002466:Cell Nucleolus / Q000502:physiology*; D002842:Chromatids / Q000235:genetics / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone; D004275:DNA, Ribosomal / Q000235:genetics / Q000502:physiology; D004789:Enzyme Activation; D005656:Fungal Proteins / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D014158:Transcription, Genetic; D000097722:Cohesins
D064127:Aurora Kinases; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004275:DNA, Ribosomal; D005656:Fungal Proteins; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; D017027:Protein Tyrosine Phosphatases; D029701:Saccharomyces cerevisiae Proteins; D000097722:Cohesins; C074860:CDC14 protein, S cerevisiae