title: [Molecular mechanism of wendan tang in prevention of lipid metabolism disorder in adult rats].
abstract: OBJECTIVE
  To elucidate the molecular mechanism of Wendan Tang in prevention of lipid metabolism disorder in adult rats.
  
  
  METHODS
  On the basis of hyperlipidemia rat models, triglycerides (TG), total cholesterol (TC) in serum, activities of lipase (LA), lipoprotein lipase (LPL), hepatic lipase (HL) in liver, parts of hemogram and hepatic LDLR mRNA levels were investigated 21 days after the feeding of atherogenic diet.
  
  
  RESULTS
  Wendan Tang significantly reduced the serum TG, TC and increased the activity of LPL and LA, but caused no chang in HL. The result of RT-PCR test showed that high fat and high cholesterol feeding could significantly induce the reduction of LDLR mRNA levels, while Wendan Tang could increase hepatic LDLR density.
  
  
  CONCLUSIONS
  Wendan Tang can prevent disorder of lipid metabolism by regulating TC, TG, LDL-c through upregaulation of LDLR transcription level and improving antioxidant ability.
authors.affiliation: Sichuan University, Chengdu 610064, Sichuan, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chun
authors.forename: Jia-lan
authors.initials: JL
authors.lastname: Li
authors.forename: Dong-hui
authors.initials: DH
authors.lastname: Cheng
authors.forename: Xia
authors.initials: X
authors.lastname: Luo
authors.forename: Zhi-rong
authors.initials: ZR
authors.lastname: Yang
mesh_terms: D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006949:Hyperlipidemias / Q000097:blood* / Q000378:metabolism / Q000517:prevention & control; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D011973:Receptors, LDL / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D011973:Receptors, LDL