title: Transforming growth factor-beta1 in the urine of young children with urinary tract infection.
abstract: Urinary tract infection (UTI) is a frequent cause of morbidity during the first years of life and may lead to renal insufficiency. Transforming growth factor-beta1 (TGF-beta) is both immunoregulatory and an important mediator of interstitial fibrosis. TGF-beta was detected in the urine of 52% of 48 children aged 1-24 months with a first episode of UTI (94% due to Escherichia coli) and no obstructive nephropathy compared with 0 of 20 healthy young children (P<0.001). TGF-beta was detected in the urine only during the early stage (<1 day) after initiation of treatment. It was detected more frequently (P=0.06) and in significantly higher concentrations (P=0.046) in children with a normal (99m )Tc-dimercaptosuccinic acid scan compared with those with abnormal scans performed 3-14 days after the diagnosis of UTI, suggesting a regulatory role in fibrogenesis and outcome of pyelonephritis in childhood.
authors.affiliation: 3rd Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, 49 Konstantinoupoleos Street, Thessaloniki 54642, Greece. roilides@med.auth.gr
authors.forename: Evangelia
authors.initials: E
authors.lastname: Farmaki
authors.forename: Fotis
authors.initials: F
authors.lastname: Papachristou
authors.forename: Richard M
authors.initials: RM
authors.lastname: Winn
authors.forename: Nicolas
authors.initials: N
authors.lastname: Karatzas
authors.forename: John
authors.initials: J
authors.lastname: Sotiriou
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Roilides
mesh_terms: D002675:Child, Preschool; D005260:Female; D005355:Fibrosis / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D011704:Pyelonephritis / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000032:analysis* / Q000276:immunology*; D053773:Transforming Growth Factor beta1; D014552:Urinary Tract Infections / Q000150:complications / Q000276:immunology* / Q000652:urine
chemical_list: C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1