Effect of nonselective and selective opioid receptors antagonists on antinociceptive action of acetaminophen [part III].
The influence of naloxone (NAL), a competitive antagonist of mu, kappa, delta and sigma receptors; D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH(2) (CTOP), selective antagonist of mu-opioid receptors; nor-binaltorphimine (NOR-BNI), a potent and higly selective kappa opioid receptor antagonist; naltrindole (NTI), a delta-opioid receptor antagonist and naltriben (NTB), a highly selective delta(2)-opioid receptor antagonist on antinociceptive action of acetaminophen (ACETA) was studied in rats. NAL administered intraperitoneally (ip) or intracerebroventricularly (icv), and CTOP and NOR-BNI administered icv, markedly decreased the antinociceptive activity of the high dose of ACETA (400 mg/kg). Pretreatment with NTI (sc), as well as with naloxone (it), and NTB (it) slightly but significantly attenuated the ACETA antinociception. The possible involvement of the opioidergic systems in antinociceptive activity of ACETA is discussed.
Bujalska
M
M
Department of Pharmacodynamics, Medical University of Warszawa, Krakowskie Przedmieście 26/28, PL 00-927 Warszawa, Poland. mbujalski@profilsp.com.pl
D000082:Acetaminophen / Q000494:pharmacology*; D000698:Analgesia / Q000379:methods; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D008297:Male; D009292:Narcotic Antagonists / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000502:physiology
D000700:Analgesics; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D000082:Acetaminophen