[Killer immunoglobulin-like receptor gene distribution in Guangdong Han population].
OBJECTIVE
To investigate the distribution of killer immunoglobulin-like receptor (KIR) gene in Guangdong Han population.


METHODS
KIR phenotype was examined by PCR with sequence-specific primers in 96 subjects of Han nationality in Guangdong Province of China, and KIR frequency was calculated and compared with those in Caucasian, north Indian and Japanese populations.


RESULTS
The gene expression frequency of KIR in Guangdong Han people was 2DL1(0.85), 2DL2(0.12), 2DL3(0.58), 2DL4(1), 2DL5(0.24), 3DL1(0.96), 3DL2(1), 3DL3(1), 2DP1(0.97), 2DP2(0.98), 2DS1(0.10), 2DS2(0.30), 2DS3(0.02), 2DS4(0.28), 1D(0.65), 2DS5(0.19), and 3DS1(0.23) respectively. Comparison of the KIR recognizing the same HLA ligand suggested significantly higher expression frequency of inhibitory KIR than that of activating KIR. Compared with Caucasian and north Indian populations, Guangdong Han population had significantly lower expression frequency of activating KIR gene with the exception of KIR2DS4.


CONCLUSIONS
Different KIR genes have different expression frequencies in Guangdong Han population, and KIR gene distribution varies between populations of different races.
Yin
Xiao-lin
XL
Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. yin-xl@163.com
Guo
Kun-yuan
KY
Ma
Hong-jing
HJ
Shang
Zheng-chuan
ZC
Xiao
Lu-lu
LL
Ye
Xin
X
Zhao
Yang
Y
D000328:Adult; D002681:China / Q000208:ethnology; D005787:Gene Frequency; D006680:HLA Antigens / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000235:genetics*; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054344:Receptors, KIR2DL3; D054345:Receptors, KIR2DL4; D054341:Receptors, KIR3DL1; D054347:Receptors, KIR3DL2; D054349:Receptors, KIR3DS1
D006680:HLA Antigens; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054344:Receptors, KIR2DL3; D054345:Receptors, KIR2DL4; D054341:Receptors, KIR3DL1; D054347:Receptors, KIR3DL2; D054349:Receptors, KIR3DS1