[The synthesis and antiherpetic activity of acyclovir phosphonate esters].
Alkyl esters of acyclovir phosphite, alkoxycarbonylphosphonate, ethoxycarbonylmethylphosphonate, and aminocarbonylphosphonate were synthesized. Most of them were shown to inhibit the replication of type 1 herpes simplex virus in Vero cell culture. The stability in phosphate buffer and human blood serum was studied for several of the derivatives. A correlation between the stability and antiviral activity of the synthesized compounds is discussed. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 6; see also http://www.maik.ru.
Ias'ko
M V
MV
Ulanova
N Iu
NIu
Andronova
V L
VL
Ivanov
A V
AV
Karpenko
I L
IL
Kukhanova
M K
MK
Galegov
G A
GA
Skoblov
Iu S
IuS
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002522:Chlorocebus aethiops; D004355:Drug Stability; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000494:pharmacology; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
D063065:Organophosphonates; D000212:Acyclovir