Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease.
BACKGROUND
The National Kidney Foundation has advocated the use of the abbreviated Modification of Diet in Renal Disease (MDRD) equation to estimate glomerular filtration rate (GFR) from serum creatinine measurements in clinical laboratories. However, healthy persons were not included in the development of the MDRD equation.


OBJECTIVE
To assess the accuracy of the MDRD equation in patients with chronic kidney disease compared with healthy persons and to develop a new equation that uses both patients with chronic kidney disease and healthy persons.


METHODS
Cross-sectional study.


METHODS
The Mayo Clinic, a tertiary-care medical center.


METHODS
Consecutive patients (n = 320) who had an iothalamate clearance test specifically for chronic kidney disease evaluation and consecutive healthy persons (n = 580) who had an iothalamate clearance test specifically for kidney donor evaluation.


METHODS
Serum creatinine levels, GFR, demographic characteristics, and clinical characteristics were abstracted from the medical record.


RESULTS
The MDRD equation underestimated GFR by 6.2% in patients with chronic kidney disease and by 29% in healthy persons. Re-estimated coefficients for serum creatinine and sex were similar to the original MDRD equation in the chronic kidney disease series but not in the healthy series. At the same serum creatinine level, age, and sex, GFR was on average 26% higher in healthy persons than in patients with chronic kidney disease (P < 0.001). A quadratic GFR equation was developed to estimate logarithmic GFR from the following covariates: 1/SCr, 1/SCr2, age, and sex (where SCr = serum creatinine).


CONCLUSIONS
The new equation was not developed in a general population sample. Elderly and African-American persons were underrepresented.


CONCLUSIONS
The MDRD equation systematically underestimates GFR in healthy persons. A new equation developed with patients who have chronic kidney disease and healthy persons may be a step toward accurately estimating GFR when the diagnosis of chronic kidney disease is unknown.
Rule
Andrew D
AD
Mayo Clinic, Rochester, Minnesota 55905, USA.
Larson
Timothy S
TS
Bergstralh
Erik J
EJ
Slezak
Jeff M
JM
Jacobsen
Steven J
SJ
Cosio
Fernando G
FG
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003287:Contrast Media; D003404:Creatinine / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007483:Iothalamic Acid / Q000493:pharmacokinetics; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012016:Reference Values
D003287:Contrast Media; D007483:Iothalamic Acid; D003404:Creatinine