title: The associations of anxiety, depression and personal illness representations with glycaemic control and health-related quality of life in patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  This study examined the interrelationships of anxiety, depression and personal illness representations with glycaemic control and health-related quality of life in adults with Type 2 diabetes.
  
  
  METHODS
  One hundred eighty-four consecutive patients with Type 2 diabetes mellitus completed the Illness Perception Questionnaire (IPQ), the Well-Being Scale (WBQ) and the Short Form 36 Health Survey Questionnaire (SF-36). Demographic characteristics, details of diabetes status (duration of diabetes, treatments and complications) and glycosylated haemoglobin (HbA1c) were recorded.
  
  
  RESULTS
  Depression was correlated with greater perceived symptom load (r = .48, P < .01), worse anticipated consequences (r = -.41, P < .01) and perceived lack of control of diabetes (r = .28, P < .01). After controlling for demographic and illness characteristics, personal illness representations relating to symptom load and anticipated consequences were independently associated with the SF-36 physical functioning score, contributing an additional 15% to the variance. WBQ depression and anxiety scores, along with IPQ control and consequences, were independently associated with SF-36 mental function score, contributing a further 51% to the variance after controlling for demographic and illness details. Neither IPQ nor WBQ scales were associated with HbA1c after controlling for demographic and medical illness details.
  
  
  CONCLUSIONS
  Anxiety, depression and negative beliefs about illness influence physical and mental functioning, but not metabolic control in patients with diabetes.
authors.affiliation: Diabetes Research Group, Manchester Diabetes Centre, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
authors.forename: C
authors.initials: C
authors.lastname: Paschalides
authors.forename: A J
authors.initials: AJ
authors.lastname: Wearden
authors.forename: R
authors.initials: R
authors.lastname: Dunkerley
authors.forename: C
authors.initials: C
authors.lastname: Bundy
authors.forename: R
authors.initials: R
authors.lastname: Davies
authors.forename: C M
authors.initials: CM
authors.lastname: Dickens
mesh_terms: D000368:Aged; D001007:Anxiety; D001294:Attitude to Health; D001786:Blood Glucose; D003430:Cross-Sectional Studies; D003863:Depression; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012720:Severity of Illness Index
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents