Review article: The eosinophil as a therapeutic target in gastrointestinal disease.
Elevated levels of eosinophils in the gastrointestinal tract is a common feature of numerous gastrointestinal disorders including food allergy, parasitic infections, gastro-oesophageal reflux, eosinophilic oesophagitis, eosinophilic gastroenteritis, allergic colitis and inflammatory bowel diseases. Recently, clinical and experimental studies have provided evidence that eosinophils have a critical role in the pathophysiology of eosinophil-associated gastrointestinal disease. Collectively, these studies have provided relevant insight into identifying key targets for therapeutic intervention. The present review describes recent experimental investigations on the role of eosinophils in the clinical manifestations of eosinophil-associated gastrointestinal disease and discusses future therapeutic approaches for the treatment of disease.
Hogan
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SP
Cincinnati Children's Hospital Medical Center, Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA. simon.hogan@cchmc.org
Rothenberg
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ME
D000818:Animals; D016535:Bronchial Hyperreactivity / Q000150:complications; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000037:antagonists & inhibitors; D002630:Chemotactic Factors / Q000502:physiology; D004804:Eosinophils; D005767:Gastrointestinal Diseases / Q000473:pathology / Q000628:therapy*; D006801:Humans; D051379:Mice; D008954:Models, Biological
C515456:CCL11 protein, human; C515457:Ccl11 protein, mouse; D054413:Chemokine CCL11; D019742:Chemokines, CC; D002630:Chemotactic Factors