title: Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease.
abstract: We analyzed the concentrations of four chemokines in the cerebrospinal fluid (CSF) and sera in Vogt-Koyanagi-Harada disease (VKH), an autoimmune uveomeningitis syndrome against melanocyte-associated proteins, with ELISA. CSF-CXCL10/IP-10 and CSF-CCL17/TARC were significantly elevated in VKH than in controls. In the majority of VKH cases and controls, CSF-CXCL10 was higher than serum-CXCL10, and CSF-CCL17 was lower than serum-CCL17. CCL11/Eotaxin was not different between groups. CSF-CCL2/MCP-1 was significantly lower in VKH than in control. The changes in VKH were essentially similar to those in multiple sclerosis, a known Th1-dominant condition.
authors.affiliation: Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai 980-8574, Japan.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Miyazawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Abe
authors.forename: Koichi
authors.initials: K
authors.lastname: Narikawa
authors.forename: Juan
authors.initials: J
authors.lastname: Feng
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Misu
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakashima
authors.forename: Juichi
authors.initials: J
authors.lastname: Fujimori
authors.forename: Makoto
authors.initials: M
authors.lastname: Tamai
authors.forename: Kazuo
authors.initials: K
authors.lastname: Fujihara
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Itoyama
mesh_terms: D000293:Adolescent; D000328:Adult; D018925:Chemokines / Q000097:blood* / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D014607:Uveomeningoencephalitic Syndrome / Q000097:blood* / Q000134:cerebrospinal fluid*
chemical_list: D018925:Chemokines