title: 2B4 co-stimulation: NK cells and their control of adaptive immune responses.
abstract: NK cells have primarily been defined by their ability to kill infected cells, tumor cells and some normal cells expressing low levels of MHC class I molecules. NK cells have also been shown to affect adaptive immune responses by their production of both pro- and anti-inflammatory cytokines. Recently it has been shown that adaptive immune responses can be enhanced or maintained also through direct lymphocyte-lymphocyte interactions. One of these interactions was identified to occur between 2B4 and CD48, where 2B4 acted as a co-stimulatory ligand for both NK cells and T cells. In the current article, we discuss the role of 2B4 in the development of adaptive immune responses and the role of NK-T cell interactions in these responses.
authors.affiliation: Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, F59, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
authors.forename: Erika
authors.initials: E
authors.lastname: Assarsson
authors.forename: Taku
authors.initials: T
authors.lastname: Kambayashi
authors.forename: Catrine M
authors.initials: CM
authors.lastname: Persson
authors.forename: Hans-Gustaf
authors.initials: HG
authors.lastname: Ljunggren
authors.forename: Benedict J
authors.initials: BJ
authors.lastname: Chambers
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D002450:Cell Communication / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D011971:Receptors, Immunologic / Q000502:physiology*; D000071176:Signaling Lymphocytic Activation Molecule Family; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015703:Antigens, CD; C084093:CD244 protein, human; C490007:Cd244a protein, mouse; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D000071176:Signaling Lymphocytic Activation Molecule Family