title: Control of cell cycle progression by the stress-activated Hog1 MAPK.
abstract: Activation of the stress-activated Hog1 kinase is essential for cell survival in response to high osmolarity. The Hog1 SAPK elicits the program for cell adaptation that includes modulation of several aspects of cell biology, such as, gene expression, translation and cell-cycle progression. In response to stress, the Hog1 SAPK mediates a transient cell cycle arrest required for proper cell adaptation. A recent report has described the mechanism underlying the effect of the SAPK at G1. Here, we propose that the mechanisms that involve cell cycle control in response to osmostress are of great complexity and that they could be conserved among eukaryotic cells.
authors.affiliation: Cell Signaling Unit, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Zapater
authors.forename: Josep
authors.initials: J
authors.lastname: Clotet
authors.forename: Xavier
authors.initials: X
authors.lastname: Escoté
authors.forename: Francesc
authors.initials: F
authors.lastname: Posas
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D016213:Cyclins / Q000235:genetics / Q000502:physiology; D016193:G1 Phase / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D005800:Genes, Fungal; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000502:physiology*; D009994:Osmolar Concentration; D014176:Protein Biosynthesis / Q000235:genetics / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D050756:Cyclin-Dependent Kinase Inhibitor Proteins; D016213:Cyclins; C086926:SIC1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C088589:HOG1 protein, S cerevisiae; D020928:Mitogen-Activated Protein Kinases