title: Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection.
abstract: We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R(-/-) mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.
authors.affiliation: Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
authors.forename: Michelle N
authors.initials: MN
authors.lastname: Kelly
authors.forename: Jay K
authors.initials: JK
authors.lastname: Kolls
authors.forename: Kyle
authors.initials: K
authors.lastname: Happel
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Schwartzman
authors.forename: Paul
authors.initials: P
authors.lastname: Schwarzenberger
authors.forename: Crescent
authors.initials: C
authors.lastname: Combe
authors.forename: Magali
authors.initials: M
authors.lastname: Moretto
authors.forename: Imtiaz A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D000818:Animals; D002465:Cell Movement; D005260:Female; D020381:Interleukin-17 / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000276:immunology*; D010529:Peritoneal Cavity / Q000166:cytology; D018123:Receptors, Interleukin / Q000502:physiology*; D053722:Receptors, Interleukin-17; D015398:Signal Transduction; D014124:Toxoplasmosis, Animal / Q000276:immunology*
chemical_list: C491673:Il17ra protein, mouse; D020381:Interleukin-17; D018123:Receptors, Interleukin; D053722:Receptors, Interleukin-17