title: A latex test for canine rheumatoid factor.
abstract: Canine rheumatoid factor (RF) has been reported in several canine diseases, particularly in arthritis. Although RF can be assayed using IgG sensitized erythrocytes, the test has a number of disadvantages. As an alternative, latex sensitized with canine IgG was investigated as an assay of canine RF. The canine IgG-latex could be easily produced, was stable, and could be standardized with commercial antisera. The reagent detected RF of the IgM anti-canine-aggregated-IgG type. A comparison of the titres obtained using the canine IgG-latex reagent with those obtained using a rabbit IgG-erythrocyte reagent showed no correlation, suggesting that the two assays may detect RF of different specificities.
authors.affiliation: Department of Immunology, Merck Institute for Therapeutic Research, Rahway, New Jersey 07065, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Wood
authors.forename: A I
authors.initials: AI
authors.lastname: Hurvitz
authors.forename: R D
authors.initials: RD
authors.lastname: Schultz
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis / Q000276:immunology*; D004285:Dogs; D005260:Female; D007074:Immunoglobulin G; D007841:Latex Fixation Tests / Q000379:methods / Q000662:veterinary*; D008297:Male; D008863:Microspheres; D012217:Rheumatoid Factor / Q000032:analysis* / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D012217:Rheumatoid Factor