title: The intelligent data management system for toxicogenomics.
abstract: Toxicogenomics is now emerging as one of the most important genomic application because the toxicity test based on gene expression profiles is expected to be more precise and efficient than current histopathological approaches in a pre-clinical phase. One of the challenging issues in toxicogenomics is the construction of intelligent database management system which can deal with heterogeneous and complex data from many different experimental and information sources. TEST(Toxicogenomics for Efficient Safety Test) database is especially focused on the connectivity of heterogeneous data and the intelligent query system which enable users to obtain relevant useful information from the complex data sets. The database deals with four kinds of information; compound, histopathology, gene expression, and annotation information. Currently, TEST database maintains toxicogenomics information for 16 compounds, 45 microarrays, 190 animal experiments, and customized 4.8 K rat clone set. Our presented system is expected to be a good information source for studying of toxicology mechanism in the genome-wide level and can also be applied to the designing toxicity test chip.
authors.affiliation: Bioinformatics Unit, ISTECH Inc., Goyang, Gyeonggi-do, South Korea.
authors.forename: Wan-Seon
authors.initials: WS
authors.lastname: Lee
authors.forename: Gyoum-Jung
authors.initials: GJ
authors.lastname: Lee
authors.forename: Gyoung-Jae
authors.initials: GJ
authors.lastname: Lee
authors.forename: Chan-Dong
authors.initials: CD
authors.lastname: Yeo
authors.forename: Jong-Soo
authors.initials: JS
authors.lastname: Kang
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Kim
authors.forename: Seung-Jun
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jun-Sub
authors.initials: JS
authors.lastname: Kim
authors.forename: Seung Yong
authors.initials: SY
authors.lastname: Hwang
authors.forename: Joon-Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Jae-Woong
authors.initials: JW
authors.lastname: Hwang
authors.forename: Kyung-Sun
authors.initials: KS
authors.lastname: Kang
authors.forename: Yong-Soon
authors.initials: YS
authors.lastname: Lee
authors.forename: Ki-Seon
authors.initials: KS
authors.lastname: Jeon
authors.forename: Chan-Hwi
authors.initials: CH
authors.lastname: Um
authors.forename: Seok-Il
authors.initials: SI
authors.lastname: Hong
authors.forename: Yang-Seok
authors.initials: YS
authors.lastname: Kim
mesh_terms: D000818:Animals; D016208:Databases, Factual; D043922:Toxicogenetics