[Experimental study of puerarin injection on the hemorheology in acute blood-stasis model rats].
OBJECTIVE
To observe the effect of Puerarin Injection on the hemorheology in acute blood-stasis model rats.


METHODS
The acute blood-stasis model rats were made by being soaked in ice water afer being injected adrenaline hydrochloride injection in a major dose. The changes of viscosity of whole blood and plasma, blood yield stress, erythrocyte aggregation and the maximum rate of platelet aggregation in the acute blood-stasis model rats were measured with Auto-Viscometer, and then the influence of Puerarin Injection on the hemorheology in the model rats was investigated.


RESULTS
The viscosity of whole blood and plasma, and blood yield stress in the acute blood-stasis model rats were significantly higher than those in the normal control group (P < 0.01, P < 0.05). Both the high dose and the low dose of Puerarin Injection could reduce the viscosity of whole blood and plasma, blood yield stress and the maximum rate of platelet aggregation in the acute blood-stasis model rats (P < 0.01, P < 0.05). The high dose could also reduce the erythrocyte aggregation and the deformed Index of red blood cell (P < 0.05).


CONCLUSIONS
Puerarin Injection can ameliorate the hemorheology in acute blood-stasis model rats, and it has a dose-response relationship.
Pan
Hong-ping
HP
People's Hospital of Guangxi Autonomous Region, Nanning 530021, Guangxi, China.
Yang
Jia-zhen
JZ
Li
Lu-li
LL
Yi
Fei
F
Huang
Zhuo-qun
ZQ
Huang
Kai-wen
KW
D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood*; D001809:Blood Viscosity / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D018056:Hemorheology / Q000187:drug effects*; D007267:Injections; D007529:Isoflavones / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D029908:Pueraria / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D007529:Isoflavones; C033607:puerarin