Anti-inflammatory, antinociceptive, and antipyretic effects of Lantana trifolia Linnaeus in experimental animals.
Lantana trifolia L. (Verbenaceae) is traditionally used as an anti-inflammatory medicinal plant in Venezuela. The methanol extract of the aerial parts of L. trifolia were assessed for the anti-inflammatory, anti-nociceptive and anti-pyretic properties. The extract produced an inhibition of carrageenan-induced edema in the rat paw over a dose range of 10-300 mg/kg i.p.; the dose-response curve was bell-shaped with a maximal effect at 100 mg/kg. The extract also produced a small but significant increase in the response latency of rats subjected to the hot plate, a thermal pain test that only detects analgesia by high-efficacy agents. The extract did not exhibit antipyretic activity. Thus, the L. trifolia extract could have therapeutically relevant anti-inflammatory and analgesic properties in humans.
Uzcátegui
Bercy
B
Natural Products Laboratory, Faculty of Sciences, University of Zulia, Maracaibo, Venezuela.
Avila
Dinorah
D
Suárez-Roca
Heberto
H
Quintero
Luis
L
Ortega
José
J
González
Beatriz
B
D000700:Analgesics / Q000627:therapeutic use; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy; D032410:Lantana; D008297:Male; D010146:Pain / Q000188:drug therapy; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D028321:Plant Preparations