Apelin signalling: a promising pathway from cloning to pharmacology.
The discovery of new signalling pathways is always followed by the development of pharmacological agents as drugs that can be used in the treatment of diseases resulting from a dysfunction of the signalling pathway in question. Apelin signalling plays a role in the central and peripheral regulation of the cardiovascular system, in water and food intake, and possibly in immune function. Up-regulation of ligand and receptor is also associated with pathophysiological states such as cardiac dysfunction and neovascularisation. Finally, the apelin receptor is a coreceptor for the entry of several HIV-1 and SIV strains. In view of these features, the apelin receptor constitutes a very interesting target for the design of new drugs for treating the prime causes of human mortality.
Masri
B
B
Unité INSERM U-589, TSA 50032, C.H.U. Rangueil, Bât. L3, 1 avenue Jean Poulhès, 31059-Toulouse Cedex 9, France.
Knibiehler
B
B
Audigier
Y
Y
D000818:Animals; D000073861:Apelin; D000075244:Apelin Receptors; D002319:Cardiovascular System / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics*; D002490:Central Nervous System / Q000502:physiology; D003001:Cloning, Molecular; D015195:Drug Design; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics*; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship
C115436:APLN protein, human; C104575:APLNR protein, human; D000073861:Apelin; D000075244:Apelin Receptors; D002352:Carrier Proteins; D036341:Intercellular Signaling Peptides and Proteins; D043562:Receptors, G-Protein-Coupled