title: Molecular detection of Treponema denticola and Porphyromonas gingivalis in carotid and aortic atheromatous plaques by FISH: report of two cases.
abstract: Treponema denticola and Porphyromonas gingivalis have been identified in atheromatous plaques of two patients suffering from atherosclerosis by PCR and fluorescence in situ hybridization (FISH). The use of the FISH technique suggested that these periodontopathic micro-organisms might be metabolically active within the wall of arteries, under the atherosclerotic lesion.
authors.affiliation: Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Cavrini
authors.affiliation: Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Sambri
authors.affiliation: Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy.
authors.forename: Annette
authors.initials: A
authors.lastname: Moter
authors.affiliation: Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy.
authors.forename: Dora
authors.initials: D
authors.lastname: Servidio
authors.affiliation: Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Marangoni
authors.affiliation: Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Montebugnoli
authors.affiliation: Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Foschi
authors.affiliation: Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Prati
authors.affiliation: Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Bartolomeo
authors.affiliation: Section of Microbiology, DMCSS, University of Bologna, Bologna, Italy 2Institut für Mikrobiologie und Hygiene, Charitè Universitätsmedizin, Berlin, Germany 3Department of Oral Sciences, University of Bologna, Bologna, Italy 4Department of Surgical Sciences, Anaesthesiology and Transplants, University of Bologna, Bologna, Italy 5Centro Regionale di Riferimento per le Emergenze Microbiologiche, Bologna, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cevenini
mesh_terms: D000368:Aged; D001011:Aorta / Q000382:microbiology; D001018:Aortic Diseases / Q000382:microbiology*; D001161:Arteriosclerosis / Q000382:microbiology*; D002339:Carotid Arteries / Q000382:microbiology; D002340:Carotid Artery Diseases / Q000382:microbiology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D016133:Polymerase Chain Reaction; D016966:Porphyromonas gingivalis / Q000235:genetics / Q000302:isolation & purification*; D048373:Treponema denticola / Q000235:genetics / Q000302:isolation & purification*