[Favorable effect of trimetazidine on clinical state and left ventricular function postinfarction period.].
OBJECTIVE
To assess effect of trimetazidine on clinical course of postinfarction period and restoration of left ventricular myocardium.


METHODS
1.5-2.0 months after acute myocardial infarctions 123 patients receiving conventional therapy (aspirin, beta-blockers, angiotensin converting enzyme inhibitors, nitrates) were divided into 2 groups. Patients of group 1 (n=62) were given 60 mg/day of trimetazidine and patients of group 2 (n=61) were not. All patients were followed up for 12 months after onset of myocardial infarction.


RESULTS
12 months after myocardial infarction decreases of average heart failure and angina classes, increase of left ventricular ejection fraction, reduction of left ventricular end systolic and end diastolic volumes and left atrial dimensions occurred in group 1. Ejection fraction in this group became significantly higher while left ventricular end systolic and end diastolic volumes and left atrial dimensions significantly lower than in group 2. Index of diastolic function V(e)/V(a)ased in trimetazidine treated patients with normal and hypertrophic types of transmitral diastolic blood flow and became higher than in group 2.


CONCLUSIONS
Trimetazidine facilitates restoration of systolic and diastolic left ventricular function after myocardial infarction.
Gorbachenkov
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AA
Russian State Medical University; ul. Ostrovityanova 1, 117437 Moscow, Russia; Municipal Hospital #2, Korolev City, Moscow Region.
Khobot
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VV
D003971:Diastole / Q000187:drug effects; D006352:Heart Ventricles; D006801:Humans; D009203:Myocardial Infarction; D014292:Trimetazidine / Q000494:pharmacology; D016277:Ventricular Function, Left / Q000187:drug effects
D014292:Trimetazidine