CYP3A4*18: it is not rare allele in Japanese population.
We sequenced all 13 exons of the CYP3A4 gene derived from 48 Japanese subjects. One subject possess the 20070 T>C mutation in the exon 10 (result in leu293Pro substitution, namely CYP3A4(*)18), as heterozygote. Thus, we investigated the frequency of CYP3A4(*)18 in 118 Japanese population using polymerase chain reaction-restriction fragment length polymorphism with Msp I and determined that the frequency of the CYP3A4(*)18 allele was 1.3%.
Yamamoto
Takehito
T
Department of Pharmacy, University of Tokyo Hospital, Japan.
Nagafuchi
Nobue
N
Ozeki
Takeshi
T
Kubota
Takahiro
T
Ishikawa
Hiroshi
H
Ogawa
Seishi
S
Yamada
Yasuhiko
Y
Hirai
Hisamaru
H
Iga
Tatsuji
T