title: Surgical treatment for anomalous arrangement of the pancreaticobiliary duct with nondilatation of the common bile duct.
abstract: OBJECTIVE
  For anomalous arrangement of the pancreaticobiliary duct (AAPBD) with nondilatation of the common bile duct (CBD), the optimal surgical procedure remains controversial. The authors investigated which procedure would be most effective for AAPBD with nondilatation of the CBD.
  
  
  METHODS
  The authors encountered 60 children with AAPBD in our institution between 1979 and 2002. Six of the 60 were classified as the nondilated type (CBD diameter; less than 8 mm), whereas the other 54 were classified as the dilated type (CBD diameter; more than 9 mm). Amylase levels in serum, CBD, and gallbladder were examined. Cellular activity of the resected gallbladder was examined for the incidence of hyperplasia and Ki-67 labeling index (Ki-67 LI).
  
  
  RESULTS
  The amylase level in the nondilated type was elevated as in the dilated type. Epithelial hyperplasia of the gallbladder was present in 4 of the 6 with the nondilated type (67%). 10 of the 20 with the dilated type (50%), and none of the 6 controls (0%). The Ki-67 LI of the dilated type was significantly higher than that of control.
  
  
  CONCLUSIONS
  A free reflux of pancreatic juice into the biliary system was found regardless of dilatation, and cellular proliferative activity of the gallbladder mucosa was increased in both the nondilated and dilated type. Therefore, excision of the extrahepatic bile duct including cholecystectomy is recommended for AAPBD with nondilatation of the CBD.
authors.affiliation: Division of Surgery, Children's Research Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Iwai
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Fumino
authors.forename: Tomoki
authors.initials: T
authors.lastname: Tsuda
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ono
authors.forename: Osamu
authors.initials: O
authors.lastname: Kimura
authors.forename: Eiichi
authors.initials: E
authors.lastname: Deguchi
mesh_terms: D000015:Abnormalities, Multiple / Q000601:surgery*; D000293:Adolescent; D001652:Bile Ducts / Q000002:abnormalities* / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003135:Common Bile Duct; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010183:Pancreatic Ducts / Q000002:abnormalities* / Q000601:surgery*