title: Down-regulation of DNA polymerases kappa, eta, iota, and zeta in human lung, stomach, and colorectal cancers.
abstract: Human DNA polymerases kappa, eta, iota, and zeta are responsible for the translesion DNA synthesis. Numerous in vitro studies indicated that these enzymes may contribute to DNA lesion-triggered and spontaneous mutation. We measured the transcripts of these 4 enzymes in 131 self-paired cancerous and non-tumor samples, including 23 lung cancers, 49 stomach cancers, and 59 colorectal cancers. Our results indicated that, except pol eta in colorectal cancers, these enzymes are all significantly down-regulated in human lung, stomach, and colorectal cancers, suggesting that these enzymes are probably not closely associated with the elevated mutations in human cancer.
authors.affiliation: Cancer Institute, The Second Affiliated Hospital, The Medical Collage, Zhejiang University, 88 Jiefang Road, Hangzhou, Zhejiang Province, P.R. China.
authors.forename: Qiangrong
authors.initials: Q
authors.lastname: Pan
authors.forename: Yongming
authors.initials: Y
authors.lastname: Fang
authors.forename: Yang
authors.initials: Y
authors.lastname: Xu
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.forename: Xun
authors.initials: X
authors.lastname: Hu
mesh_terms: D015179:Colorectal Neoplasms / Q000201:enzymology*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology*; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000201:enzymology*
chemical_list: D004259:DNA-Directed DNA Polymerase