Detecting non-multiplicative genotype relative risks from transmissions of parental alleles to affected children.
The differential transmission of alleles from parents to affected children indicates that the locus under investigation is either directly involved in the occurrence of the disease or that there are allelic associations with other loci that are directly involved. Conditional logistic regression applied to a diallelic locus leads to a test with two degrees of freedom. The power of a single degree of freedom test to detect non-multiplicative allelic effects is discussed here.
Ayres
Karen L
KL
School of Applied Statistics, The University of Reading, P.O. Box 240, Earley Gate, Reading, RG6 6FN, UK.
Curnow
Robert N
RN
School of Applied Statistics, The University of Reading, P.O. Box 240, Earley Gate, Reading, RG6 6FN, UK. r.n.curnow@reading.ac.uk.
D000483:Alleles; D002648:Child; D005260:Female; D030342:Genetic Diseases, Inborn / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010290:Parents; D012044:Regression Analysis; D012307:Risk Factors