Influence of age and hypertension on the association between small artery compliance and coronary artery disease.
Small artery elasticity index (SAEI) as determined by a new non-invasive pulse-wave contour analysis has been used to identify abnormalities of the arterial wall associated with aging, hypertension (HT), endothelial dysfunction, and coronary artery disease (CAD). The present study examined the influence and interaction of CAD risk factors on the association between SAEI in risk-associated patients with CAD (case subjects, n = 178) and without CAD (control subjects, n = 202). Case subjects had a lower SAEI than control subjects, and age was consistently and negatively correlated with SAEI. The HT was related to reduced SAEI in female subjects overall and in male case subjects. In male patients with hypertension, the association between SAEI and CAD was significant (P < .05) after considering conventional risk factors of CAD. In conclusion, age and HT should be considered when using SAEI in the early diagnosis of CAD, and lower SAEI could be of greatest diagnostic value in male patients with HT.
Takeuchi
Kazuma
K
Departments of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.
Zhang
Bo
B
Ideishi
Munehito
M
Urata
Hidenori
H
Noda
Keita
K
Tashiro
Tadashi
T
Kimura
Michio
M
Saku
Keijiro
K
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001158:Arteries / Q000187:drug effects / Q000503:physiopathology*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D048909:Diabetes Complications / Q000503:physiopathology; D004548:Elasticity / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D000960:Hypolipidemic Agents