title: Bone mineral density in the proximal femur and contralateral knee after total knee arthroplasty.
abstract: Osteoarthrosis (OA) is often associated with pain and disability, which are relieved after total knee arthroplasty (TKA), but the nature of bone changes associated with OA is controversial. We examined preoperative hip and contralateral knee bone mineral density (BMD) in patients requiring TKA and monitored the BMD changes postoperatively. Sixty-nine patients, scheduled to have TKA for osteoarthrotic knees, had both hips and contralateral knee BMD measured by dual-energy X-ray absorptiometry (DXA) at the time of operation (baseline) and at 1 yr after operation. X-rays of the knee joints were also taken to evaluate the severity of OA. Preoperatively, 27% and 38% of the patients had total hip BMD Z-score more than 1 SD in the operated side and contralateral hips, respectively. In all regions of interest (ROI), the mean baseline BMD of the affected side proximal femur was significantly lower than that of the contralateral side (p < 0.0005-0.019). The severity of OA was not associated with BMD. During 1-yr follow-up, the postoperative knee status and the physical activity of the patients (AKS score) improved. However, neither the hip nor the nonoperated knee BMDs increased. Knee OA is associated with significantly lower BMD values in the affected side compared with the contralateral hip, and these levels remained similar or decreased during a 1-yr follow-up. We conclude that improved mobility after TKA does not improve the effects of preoperative disuse-associated bone loss in the short term.
authors.affiliation: Department of Surgery, Savonlinna Central Hospital, Savonlinna, Finland. Tarja.Soininvaara@uku.fi
authors.forename: Tarja A
authors.initials: TA
authors.lastname: Soininvaara
authors.forename: Hannu J A
authors.initials: HJ
authors.lastname: Miettinen
authors.forename: Jukka S
authors.initials: JS
authors.lastname: Jurvelin
authors.forename: Esko M
authors.initials: EM
authors.lastname: Alhava
authors.forename: Heikki P J
authors.initials: HP
authors.lastname: Kröger
mesh_terms: D015502:Absorptiometry, Photon; D000367:Age Factors; D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology; D016022:Case-Control Studies; D018483:Diaphyses / Q000503:physiopathology; D005260:Female; D005269:Femur / Q000473:pathology / Q000503:physiopathology*; D005272:Femur Neck / Q000503:physiopathology; D005500:Follow-Up Studies; D006621:Hip Joint / Q000503:physiopathology; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D012737:Sex Factors; D013977:Tibia / Q000503:physiopathology