title: [Vascular invasion by tumor in the absence of regional lymph node metastases in patients with locally advanced non-small cell lung cancer].
abstract: The study included 45 patients radically operated for locally advanced (T3, T4) non-small cell lung cancer (NSCLC), free from metastasis to the regional lymph nodes. The histological subtypes were: squamous cell cancer (40; 89%), adenocarcinoma (4; 6%) and large-cell lung cancer (1; 2%). Pathomorphological stage: IIb (p T3N0M0)--35 (78%); IIIb (p T4N0M0)--10 (22%). Blood vessel invasion: tumor T3--8 (23%); T4--2 (20%). Lymph vessel invasion: T3--9 (9%) and T4--2 (2%) (p(0.05). In total, tumor invasion was reported in 16 patients: T3--12 (34%) and T4--4 (40%) (p(0.05). There was no significant difference in survival among IIb or IIIb stage NSCLC patients. None of the cases of blood vessel invasion survived 5 years after surgery. Five-year survival in patients without vascular invasion was 55% (p(001). Tumor invasion of blood and lymph vessels is associated with high probability of tumor dissemination and poor prognosis.
authors.forename: A L
authors.initials: AL
authors.lastname: Akopov
authors.forename: I V
authors.initials: IV
authors.lastname: Dvorakovskaia
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D013997:Time Factors