Pyrimidine containing RSV fusion inhibitors.
The knowledge of SAR in a series of biphenyl anionic RSV inhibitors has been broadened by synthesis and testing of analogs with pyrimidine linkers. Generally, pyrimidine compounds were much harder to synthesize, and their anti-RSV activity was lower in comparison with triazine analogs.
Nikitenko
Antonia
A
Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA. nikitea@wyeth.com
Raifeld
Yuri
Y
Mitsner
Boris
B
Newman
Howard
H
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014227:Triazines / Q000737:chemistry / Q000494:pharmacology
D000998:Antiviral Agents; D011743:Pyrimidines; D014227:Triazines