Arrestins and G-protein--coupled receptors: an on-again, off-again relationship.
Arrestins are a family of regulatory proteins that uncouple activated seven-transmembrane domain receptors from G-proteins leading to termination of ligand-induced signaling. Our understanding of arrestins has been greatly enhanced in recent years through the identification of several new members of the arrestin family, clarification of the mechanisms by which these proteins turn off receptors, and elucidation of their role as adaptor molecules in receptor internalization.
Loudon
R P
RP
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.