title: Influence of carbon dioxide on the MIC of telithromycin for Streptococcus pneumoniae: an in vitro-in vivo study.
abstract: Incubation in CO(2) resulted in higher (> or =3 doubling dilution) MICs of telithromycin than those found in ambient air for 31.2% of 346 Streptococcus pneumoniae ermB-positive strains. An increased telithromycin MIC in CO(2) was not correlated with loss of its activity in the murine sepsis/peritonitis model.
authors.affiliation: Laboratoire d'Antibiologie, UER de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France. ebatard@chu-nantes.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Batard
authors.forename: Marie Emmanuelle
authors.initials: ME
authors.lastname: Juvin
authors.forename: Cédric
authors.initials: C
authors.lastname: Jacqueline
authors.forename: Denis
authors.initials: D
authors.lastname: Bugnon
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Caillon
authors.forename: Gilles
authors.initials: G
authors.lastname: Potel
authors.forename: Henri B
authors.initials: HB
authors.lastname: Drugeon
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D002245:Carbon Dioxide / Q000494:pharmacology*; D004195:Disease Models, Animal; D006801:Humans; D048628:Ketolides / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000379:methods; D010538:Peritonitis / Q000188:drug therapy / Q000382:microbiology; D011008:Pneumococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D011500:Protein Synthesis Inhibitors; D002245:Carbon Dioxide; C106791:telithromycin