title: Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier.
abstract: Schizophyllan having folate-appendages was synthesized from native schizophyllan through NaIO(4)-oxidation and the subsequent reductive amination in aqueous ammonia followed by amido-coupling with folic acid. The resulting folate-appended schizophyllan can form stable complex with poly(dA), show specific affinity toward folate binding protein, and mediate effective antisense activity in cancer cells.
authors.affiliation: Department of Chemistry, Graduate School of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Teruaki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Shuichi
authors.initials: S
authors.lastname: Haraguchi
authors.forename: Munenori
authors.initials: M
authors.lastname: Numata
authors.forename: Ryouji
authors.initials: R
authors.lastname: Karinaga
authors.forename: Taro
authors.initials: T
authors.lastname: Kimura
authors.forename: Shiro
authors.initials: S
authors.lastname: Okumura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sakurai
authors.forename: Seiji
authors.initials: S
authors.lastname: Shinkai
mesh_terms: D001483:Base Sequence; D002352:Carrier Proteins / Q000138:chemical synthesis / Q000494:pharmacology; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D011956:Receptors, Cell Surface; D012566:Sizofiran / Q000737:chemistry* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D016376:Oligonucleotides, Antisense; D011956:Receptors, Cell Surface; D012566:Sizofiran; D005492:Folic Acid