An expeditious synthesis of beta-indolylketones catalyzed by p-toluenesulfonic acid (PTSA) using ultrasonic irradiation.
PTSA catalyzes the Michael addition of indole to alpha,beta-unsaturated carbonyl ketones under ultrasonic irradiation to afford the corresponding product beta-indolylketones in excellent yields (up to 94%).
Ji
Shun-Jun
SJ
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006, China. shunjun@suda.edu.cn <shunjun@suda.edu.cn>
Wang
Shun-Yi
SY