[High-dose urokinase for thrombolysis following replantation of severed limbs or fingers].
OBJECTIVE
To study the efficacy of intravenous urokinase administration in preventing and treating vascular crisis in limb or finger replantation (LFR).


METHODS
From September, 1999 to October, 2003, 158 patients underwent RSLF in whom 600,000 U of urokinase diluted in 30 ml saline was injected intravenously after blood vessel suture. An intermittent dose (200,000 U) per 12 h given postoperatively for maintenance. A large dose of 1,000,000-1,500,000 U of urokinase was used in the event of vascular crisis. The D-dimer, fibrinogen, hematin, and blood platelet were measured in these patients before and after urokinase administration.


RESULTS
Vascular crisis was not observed in 117 patients (74.1%) undergoing LFR, and in the 41 patients who developed vascular crisis, relief was achieved by high-dose urokinase (90.2%) with failure occurring in only 4 cases (one with wrist and 3 with finger replantation) for whom re-operation was required. The result was better than those in relevant reports.


CONCLUSIONS
A moderate dose of urokinase can be used after suturing the vessels and intermittent small doses prove feasible postoperatively to prevent thrombosis in RSLF. A high dose of urokinase can be safely used for vascular crisis management in the early stage.
Huang
Chao-tong
CT
Department of Microsurgery, Fangshuquan Hospital, Dongguan 523945, China. myhct@medmail.com.cn
Li
Jing-kuang
JK
Zhu
Jia-kai
JK
Lu
Xiao-qiang
XQ
Li
Qing-yu
QY
D000293:Adolescent; D000328:Adult; D005260:Female; D005383:Finger Injuries / Q000188:drug therapy* / Q000601:surgery*; D006230:Hand Injuries / Q000601:surgery; D006801:Humans; D008297:Male; D019990:Perioperative Care; D011184:Postoperative Period; D012092:Replantation; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
D014568:Urokinase-Type Plasminogen Activator