title: Current TNM classification of renal cell carcinoma evaluated: revising stage T3a.
abstract: OBJECTIVE
  : Recent studies of rare cases of pT3a renal cell carcinoma extending directly into the adrenal gland showed worse survival than in other pT3a cases and recategorization as stage pT4 was suggested. We assessed the prognostic validity of a stage pT3a diagnosis based on perirenal fat infiltration.
  
  
  METHODS
  : The records of 1,794 patients with renal cell carcinoma who underwent surgical resection between 1975 and 2000 at our institution were analyzed retrospectively. Focusing on pT3a tumors, as defined by perirenal fat infiltration, numerous clinical and histopathological parameters were investigated by univariate and multivariate statistical methods with cancer specific survival as the primary end point.
  
  
  RESULTS
  : We identified 237 of 1,794 patients with perirenal fat infiltration, classified as having pT3a disease. In patients with pT3a tumors tumor size was a significant parameter predicting survival. The most significant cutoff value for tumor size in pT3a disease was 7 cm. Patients with distant metastasis had a worse prognosis independent of T classification. Therefore, to assess the prognostic value of the current T classification in regard to T3a tumors we excluded patients with tumor stage cM+ for further subgroup analysis. Survival comparison of pT1 pNall, cM0 (744 of 1,794 cases) and pT3a pNall, cM0 7 cm or less (100 of 237) as well as pT2 pNall, cM0 (265 of 1,794) and pT3a pNall, cM0 greater than 7 cm (93 of 237) yielded similar results. After splitting pT3a into a modified T1/T2 classification a significant difference in 5-year survival analysis for a modified T1/T2 stage was found (pT1 plus pT3a less than 7 cm 90% vs pT2 plus pT3a greater than 7 cm 73%, p <0.001). Subsequently multivariate analysis in all 1,794 patients showed that modified T stage was an independent significant predictor of cancer specific survival.
  
  
  CONCLUSIONS
  : We suggest revising the current pT3a classification based on perirenal fat infiltration but rendering a modified pT1/pT2 classification, which resolves pT3a cases without the loss of prognostic validity. Perirenal fat infiltration should not be used to assign T category. Tumors directly infiltrating the adrenal gland should be reclassified as T4.
authors.affiliation: Department of Urology, University of the Saarland, Kirrbergerstrasse, 66421 Homburg/Saar, Germany. urssie@uniklinik-saarland.de
authors.forename: S
authors.initials: S
authors.lastname: Siemer
authors.forename: J
authors.initials: J
authors.lastname: Lehmann
authors.forename: A
authors.initials: A
authors.lastname: Loch
authors.forename: F
authors.initials: F
authors.lastname: Becker
authors.forename: U
authors.initials: U
authors.lastname: Stein
authors.forename: G
authors.initials: G
authors.lastname: Schneider
authors.forename: M
authors.initials: M
authors.lastname: Ziegler
authors.forename: M
authors.initials: M
authors.lastname: Stöckle
mesh_terms: D002292:Carcinoma, Renal Cell / Q000145:classification* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms / Q000145:classification* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009392:Nephrectomy; D011379:Prognosis; D012189:Retrospective Studies