title: Inhibition of root caries progression by an antibacterial adhesive.
abstract: A dentin primer containing the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) has been shown to penetrate and kill the bacteria in artificially demineralized dentin. We hypothesized that an experimental adhesive system, which incorporates the MDPB-containing primer, would be effective in inhibiting the progression of root caries in vitro. Artificial caries lesions were prepared by either an acid-gel or a Streptococcus mutans culture technique on the roots of extracted human teeth. The progression of these lesions after the application of the experimental or proprietary adhesive system was examined. Further demineralization was completely prevented by the experimental adhesive system, while lesions managed with the proprietary materials showed limited ability to inhibit further demineralization. We conclude that the experimental adhesive system can inhibit the progression of root-surface caries in vitro, through a combination of its antimicrobial activity and sealing of the demineralized dentin.
authors.affiliation: Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8, Yamadaoka, Suita, Osaka 565-0871, Japan. imazato@dent.osaka-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Kuramoto
authors.forename: S
authors.initials: S
authors.lastname: Imazato
authors.forename: A W G
authors.initials: AW
authors.lastname: Walls
authors.forename: S
authors.initials: S
authors.lastname: Ebisu
mesh_terms: D000096:Acetone / Q000627:therapeutic use; D000269:Adhesives / Q000737:chemistry / Q000627:therapeutic use*; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D017438:Bisphenol A-Glycidyl Methacrylate / Q000627:therapeutic use; D002327:Cariostatic Agents / Q000627:therapeutic use*; D017220:Dentin-Bonding Agents / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D019344:Lactic Acid; D008689:Methacrylates / Q000737:chemistry / Q000627:therapeutic use; D011109:Polymethacrylic Acids / Q000627:therapeutic use; D011726:Pyridinium Compounds / Q000627:therapeutic use*; D019279:Resin Cements / Q000737:chemistry / Q000627:therapeutic use; D017213:Root Caries / Q000517:prevention & control*; D013295:Streptococcus mutans; D017001:Tooth Demineralization / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000269:Adhesives; D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; C112274:Clearfil Liner Bond 2; D017220:Dentin-Bonding Agents; D008689:Methacrylates; D011109:Polymethacrylic Acids; D011726:Pyridinium Compounds; D019279:Resin Cements; C089392:methacryloyloxydodecylpyridinium bromide; C444444:prime and bond 2.1; C115612:single bond; D000096:Acetone; D019344:Lactic Acid; D017438:Bisphenol A-Glycidyl Methacrylate