[Description of an experimental model of hepatorenal syndrome in Wistar rats].
In spite of many years of experimental and clinical studies, it failed to discover precise pathomechanisms leading from hepatic damage to functional renal failure in hepatorenal syndrome (HRS). There are few reported animal models of hrs, among them a rat model induced by galactosamine (Ga1N). In this model renal failure develops typically after hepatic damage in male Sprague-Dawley rats. In our study we tried to test, whether other breeds develop typical HRS.


METHODS
We used male Wistar rats to achieve acute liver and renal failure by intraperitoneal injection of Ga1N. Liver failure developed with significant increase in serum concentration of bilirubin, AST, ALT; ammonia and massive necrosis of hepatocytes. Nevertheless, we did not achieve increase of serum creatinine and urea typical for acute renal failure.


CONCLUSIONS
We concluded that only some of rat breeds develop typical hrs, maybe because of some congenital, genetic predispositions.
Saracyn
Marek
M
Wojskowy Instytut Medyczny, Klinika Nefrologii ze Stacja Dializ CSK MON w Warszawie. msaracyn@wim.mil.pl
Kozłowski
Wojciech
W
Wańikowicz
Zofia
Z
D000410:Alanine Transaminase / Q000097:blood; D000641:Ammonia / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D004195:Disease Models, Animal; D005688:Galactosamine / Q000633:toxicity; D022781:Hepatocytes / Q000473:pathology; D006530:Hepatorenal Syndrome / Q000503:physiopathology*; D007668:Kidney / Q000473:pathology; D017093:Liver Failure / Q000139:chemically induced; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D005688:Galactosamine; D000641:Ammonia; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin