Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota.
The aim of the study was to assess the quantitative and qualitative differences of the gut microbiota in infants. We evaluated gut microbiota at the age of 6 months in 32 infants who were either exclusively breast-fed, formula-fed, nursed by a formula supplemented with prebiotics (a mixture of fructo- and galacto-oligosaccharides) or breast-fed by mothers who had been given probiotics. The Bifidobacterium, Bacteroides, Clostridium and Lactobacillus/Enterococcus microbiota were assessed by the fluorescence in situ hybridization, and Bifidobacterium species were further characterized by PCR. Total number of bifidobacteria was lower among the formula-fed group than in other groups (P=0.044). Total amounts of the other bacteria were comparable between the groups. The specific Bifidobacterium microbiota composition of the breast-fed infants was achieved in infants receiving prebiotic supplemented formula. This would suggest that early gut Bifidobacterium microbiota can be modified by special diets up to the age of 6 months.
Rinne
Minna M
MM
The University of Turku, 20014 Turku, Finland; Department of Pediatrics, Turku University Central Hospital, 20520 Turku, Finland. minrin@utu.fi
Gueimonde
Miguel
M
Kalliomäki
Marko
M
Hoppu
Ulla
U
Salminen
Seppo J
SJ
Isolauri
Erika
E
D001439:Bacteroides / Q000302:isolation & purification; D001644:Bifidobacterium / Q000145:classification / Q000302:isolation & purification*; D001942:Breast Feeding; D003013:Clostridium / Q000302:isolation & purification; D015169:Colony Count, Microbial; D019587:Dietary Supplements; D016983:Enterococcus / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005387:Finland; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007225:Infant Food; D041943:Infant Formula; D007778:Lactobacillus / Q000302:isolation & purification; D009844:Oligosaccharides / Q000008:administration & dosage; D016133:Polymerase Chain Reaction
D009844:Oligosaccharides