Sweetening cyclic peptide libraries.
Enzymatic macrolactamization of linear glycosidated peptides provides access to an important class of drug-like molecules. The work presented in this issue [1] shows that it may be possible to make complex libraries of glycosidated cyclic peptides by incorporating glycosidated amino acids into linear peptides via solid-phase peptide synthesis followed by thioesterase-mediated peptide cyclization.
Boddy
Christopher N
CN
Department of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
D003500:Cyclization; D006027:Glycosides / Q000737:chemistry*; D006031:Glycosylation; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000145:classification; D011487:Protein Conformation
D006027:Glycosides; D019151:Peptide Library; D010456:Peptides, Cyclic