title: [Chronic fatigue syndrome: a review].
abstract: Chronic fatigue sindrome is a relatively unknown and underdiagnosed entity in Italy where its epidemiology remains uncertain, as well as its etiology, although it causes important disability in those affected. Classification criteria by Fukuda are available to diagnose the syndrome. Its epidemiology indicates that it is probably more frequent in Northern countries and it is described in Gulf War veterans. Etiological hypotheses include infectious diseases, immunology and neurology. Among these hypotheses sickness behavior mimes certain aspects of this syndrome and is characterized by a cytokine imbalance in the central nervous system and in the periphery. There are no valid therapies available at the moment. In the laboratory of Immunogenetics, we are constituting a biological bank of the syndrome to study the immunogenetic aspects of the disease in the hope of delucidating some of the obscure areas of its etiopathogenesis.
authors.affiliation: Laboratorio di Immunogenetica, Dipartimento di Genetica e Microbiologia, Università, Pavia.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Carlo-Stella
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Lorusso
authors.forename: Stefano M
authors.initials: SM
authors.lastname: Candura
authors.forename: Mariaclara
authors.initials: M
authors.lastname: Cuccia
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000998:Antiviral Agents / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000276:immunology; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012737:Sex Factors
chemical_list: D000998:Antiviral Agents; D007155:Immunologic Factors; D011619:Psychotropic Drugs; D000212:Acyclovir