Cardiotoxicity and neurotoxicity of high-dose continuous fluorouracil as a result of degradation compounds in the drug vials.
Lukaschek
Johannes
J
Nufer
Martin
M
Maurer
Dominik
D
Asanger
Maximilian
M
Honegger
Hanspeter
H
Widmer
Lucas
L
Malet-Martino
Myriam
M
Legay
Rémi
R
Martino
Robert
R
D000079:Acetaldehyde / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000737:chemistry; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use*; D001927:Brain Diseases / Q000139:chemically induced*; D002277:Carcinoma / Q000188:drug therapy; D002626:Chemistry, Pharmaceutical; D004938:Esophageal Neoplasms / Q000188:drug therapy; D005079:Excipients / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D022124:Hyperammonemia / Q000139:chemically induced*; D008297:Male; D008314:Malonates / Q000009:adverse effects*; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy; D014325:Tromethamine / Q000009:adverse effects*; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced*
D000964:Antimetabolites, Antineoplastic; D005079:Excipients; D008314:Malonates; C495164:fluoromalonic acid semialdehyde; D014325:Tromethamine; C075898:fluoroacetaldehyde; D000079:Acetaldehyde; D005472:Fluorouracil