Multivariate analysis of risk factors for stillbirth in Leon, Mexico.
BACKGROUND
To identify sociodemographic and clinical risk factors for antenatal fetal death in a developing country setting.


METHODS
A case-control study was carried out, including 753 women: 251 had a stillbirth (cases) and 502 had a healthy live birth (controls). Stillbirths were considered as antenatal fetal death after 21 weeks of gestation. Seventeen sociodemographic and clinical risk factors for stillbirth were analyzed. Statistical analysis. Student's t-test or the Mann-Whitney U-test for continuous data and the chi2-test or Fisher's exact test for categorical variables were used. Logistic regression analysis was used to find significant predictors for stillbirth. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated.


RESULTS
Three risk factors were significant in the logistic regression model: maternal age (OR 1.04, 95% CI 1.00-1.08), antenatal care (OR 0.1, 95% CI 0.0-0.2) and umbilical cord complication (OR 5.8, 95% CI 3.2-10.2). The whole model had a determination coefficient of 0.280, with a chi2-value of 246.2 (p < 0.001).


CONCLUSIONS
In our setting antenatal care should be considered as the cornerstone in the prevention of stillbirth. With adequate antenatal care both women with advanced maternal age and umbilical cord complication could be identified. This finding could be useful for developing as well as developed country settings to avoid the occurrence of stillbirth.
Romero-Gutiérrez
Gustavo
G
Unit of Clinical Epidemiological Research, Department of Obstetrics and Gynecology, Mexican Institute of Social Security, Leon, Guanajuato, Mexico. gustavo.romerog@imss.gob.mx
Martínez-Ceja
Carlos Armando
CA
Abrego-Olvira
Elvira
E
Ponce-Ponce de León
Ana Lilia
AL
D000328:Adult; D016022:Case-Control Studies; D003906:Developing Countries; D005260:Female; D006801:Humans; D016015:Logistic Models; D008423:Maternal Age; D008800:Mexico / Q000453:epidemiology; D015999:Multivariate Analysis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011295:Prenatal Care; D012307:Risk Factors; D014470:Umbilical Cord