DNA repair: keeping it together.
A protein scaffold has been identified that holds a chromosome together in the event of a DNA double-strand break. This scaffold is dependent on Rad52 and the Rad50-Mre11-Xrs2 complex and withstands the pulling forces of the mitotic spindle during DNA damage checkpoint arrest.
Lisby
Michael
M
Institute of Molecular Biology, University of Copenhagen, Øster Farimagsgade 2A, DK-1353 Copenhagen K, Denmark. mlisby@my.molbio.ku.dk
Rothstein
Rodney
R
D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D019457:Chromosome Breakage / Q000502:physiology; D020090:Chromosome Segregation / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D045643:DNA Repair Enzymes / Q000378:metabolism* / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology; D051721:Rad52 DNA Repair and Recombination Protein; D008941:Spindle Apparatus / Q000502:physiology*
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D051721:Rad52 DNA Repair and Recombination Protein; D045643:DNA Repair Enzymes