Selective high-dose intra-arterial cisplatin as palliative treatment for incurable head and neck cancer.
OBJECTIVE
The purpose of the present study was to evaluate the palliative effect of selective intra-arterial chemotherapy in progressive unresectable head and neck cancer previously treated with radiochemotherapy.


METHODS
8 patients with advanced residual or recurrent squamous cell carcinoma of the head and neck were evaluated. These patients were included in the present study particularly because of progredient pain and recurrent bleedings due to tumor progression. In addition 6/8 patients suffered from unpleasant tumor-related smell. All patients received simultaneous infusions of cisplatin (150 mg/m2) intra-arterially to the tumor and sodium thiosulfate intravenously (9 g/m2) for systemic neutralization of cisplatin. The patients were treated by at most 4 cycles of selective intra-arterial chemotherapy via femoral approach.


RESULTS
Tumor-associated pain, occurrence of tumor bleeding and tumor-related smell were reduced after at least 2 cycles of intra-arterial chemotherapy in all patients. Clinical and radiological assessment of the primary tumor site revealed a partial response in 4 patients while 4 patients were classified as nonresponders. Intra-arterial cisplatin treatment was well tolerated.


CONCLUSIONS
Selective intra-arterial cisplatin therapy can be delivered safely for palliation of tumor-related symptoms of incurable head and neck cancer.
Teymoortash
A
A
Department of Otolaryngology, Head and Neck Surgery, Philipps University of Marburg, Germany. teymoort@med.uni-marburg.de
Bien
S
S
Dalchow
C
C
Sesterhenn
A
A
Lippert
B M
BM
Werner
J A
JA
D000970:Antineoplastic Agents / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005858:Germany / Q000453:epidemiology; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000628:therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000401:mortality / Q000628:therapy; D018307:Neoplasms, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000628:therapy; D010166:Palliative Care / Q000379:methods*; D017211:Treatment Failure; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D002945:Cisplatin