title: Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part I: comparison with pathologic examination.
abstract: OBJECTIVE
  To investigate the capacity of manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging (MRI) to discriminate the injured myocardium from the normal myocardium in a cat model.
  
  
  METHODS
  Fourteen cats were prepared for acute myocardial infarction with 90-minute occlusion followed by 120-minute reperfusion. Inversion recovery gradient-recalled echo (IR-GRE) MR images were obtained at 60-minute intervals for 4 hours after the injection of MnDPDP, and ex vivo after the cats were killed. We evaluated the differences between the unenhanced area on the in vivo and ex vivo MR images and the unstained area on triphenyl tetrazolium chloride (TTC) staining.
  
  
  RESULTS
  The unenhanced area on the in vivo MR images was well correlated with that on the ex vivo MR images. The unenhanced area on the ex vivo MR images was significantly larger than the unstained area on TTC staining.
  
  
  CONCLUSIONS
  This study suggests that the MnDPDP-unenhanced area on the MR images includes not only the infarcted myocardium but also the stunned myocardium.
authors.affiliation: Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Kim
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Yang
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Choi
authors.forename: Sang Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Yoon
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Shin
authors.forename: Joon Beom
authors.initials: JB
authors.lastname: Seo
authors.forename: Gyung Yub
authors.initials: GY
authors.lastname: Gong
authors.forename: Tae-Hwan
authors.initials: TH
authors.lastname: Lim
mesh_terms: D000208:Acute Disease; D000818:Animals; D002415:Cats; D003287:Contrast Media; D004195:Disease Models, Animal; D004492:Edetic Acid / Q000031:analogs & derivatives*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis* / Q000473:pathology; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid