title: Oxidative-antioxidative system in peripartum acute renal failure and preeclampsia-eclampsia.
abstract: BACKGROUND
  Preeclampsia-eclampsia and acute renal failure in peripartum women can be the cause of mortality and morbidity. There are many different reports about oxidative-antioxidative systems in preeclampsia-eclampsia. Until now, products of activated oxidative-antioxidative systems were not evaluated in peripartum women with acute renal failure. In this study, our aim was to evaluate the oxidative-antioxidative systems in peripartum women with acute renal failure and/or preeclampsia-eclampsia.
  
  
  METHODS
  The study groups consisted of 17 peripartum women (first week of delivery) with acute renal failure (G I), 11 preeclamptic (G II), 11 healthy pregnancy (> or = 30 weeks of pregnancy) (G III), and 11 healthy women (G IV) aged between 18-38 years. Superoxide dismutase (SOD), glutathione peroxidase (GSHPx) in erythrocytes, and plasma malondialdehyde (MDA) levels were measured in all groups. SOD, GSHPx, and MDA levels were also measured at the onset of acute renal failure (G IA), regression of renal dysfunction (G IB) and recovery of renal functions (G IC).
  
  
  RESULTS
  MDA levels were 11.95+/-4.25, 9.22+/-3.62, 5.10+/-3.65, 3.40+/-1.27, 4.91+/-2.06, 4.24+/-1.67 mmol/mL in G IA, G IB, G IC, G II, G III, and G IV, respectively. SOD activity in erythrocyte were 3269.23+/-1437.83, 2641.35+/-1411.13, 2056.35+/-1143.11, 924+/-160.04, 1057.91+/-257.03, 861.63+/-243.28 Ug/Hb in G IA, G IB, G IC, G II, G III, and G IV, respectively. GSHPx activity in erythrocyte was 70.17+/-23.52, 58.27+/-23.75, 45.44+/-17.60, 24.48+/-6.77, 26.28+/-7.27, 32.95+/-8.24 Ug/Hb in G IA, G IB, G IC, G II, G III, and G IV, respectively. MDA levels and activities of SOD, GSHPx in erythrocytes were highest in GIA The values of MDA, SOD, and GSH-Px in G IA, G IB, and G IC were significantly different from each other and decreased while regaining of renal functions. Preeclampsia-eclampsia or normal pregnancy did not cause elevation of plasma MDA levels and GSHPx, SOD in erythrocyte.
  
  
  CONCLUSIONS
  Although SOD and GSHPx in erythrocytes and plasma MDA level were found to be similar in healthy women, pregnant women, and preeclamptic women; SOD, GSHPx, and MDA increased at the beginning and decreased during recovery of renal functions in peripartum women with acute renal failure.
authors.affiliation: Department of Nephrology and Biochemistry, Cukurova University, Faculty of Medicine, Adana, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Balal
authors.forename: Necmiye
authors.initials: N
authors.lastname: Canacankatan
authors.forename: Saime
authors.initials: S
authors.lastname: Paydas
authors.forename: Neslihan
authors.initials: N
authors.lastname: Seyrek
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Karayaylali
authors.forename: Levent
authors.initials: L
authors.lastname: Kayrin
mesh_terms: D058186:Acute Kidney Injury / Q000201:enzymology* / Q000209:etiology / Q000401:mortality; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D004461:Eclampsia / Q000150:complications / Q000175:diagnosis / Q000201:enzymology*; D005260:Female; D005865:Gestational Age; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D008315:Malondialdehyde / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000150:complications / Q000175:diagnosis / Q000201:enzymology; D011247:Pregnancy; D011379:Prognosis; D012016:Reference Values; D012494:Sampling Studies; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000378:metabolism*; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase