title: A longitudinal study of pediatric body mass index values predicted health in middle age.
abstract: OBJECTIVE
  To characterize the use of pediatric body mass index (BMI) to predict obesity, overweight, and diseases in middle age.
  
  
  METHODS
  A longitudinal study of people born in a week in 1958 (n=12,327). The main outcome measures are obesity (BMI > or = 30) and overweight (BMI > or = 25) at age 33 and disease history self-reported at age 42. Receiver operating characteristic (ROC) analysis was performed using BMI measured at ages 7, 11, and 16 years as predictors.
  
  
  RESULTS
  BMI values measured at age 11 could predict obesity at age 33 with areas under ROC curve (AUC) of 0.78 for males and 0.80 for females (each P < .001). BMI values at age 11 predicted overweight with slightly smaller AUC (each P < .001). They could also predict history of diabetes and hypertension (AUC=0.60 and 0.56, respectively, each P < .01), both sexes pooled. Prediction based on BMI at age 7 was less satisfactory; that at 16 gave limited improvement. Cutoff points based on ROC curves, the international reference, and the 85th and 95th percentiles gave very different profiles of diagnostic features.
  
  
  CONCLUSIONS
  Pediatric BMI may predict adult obesity and overweight with a reasonable profile of sensitivity and specificity.
authors.affiliation: Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore 169610. cheungyb@graduate.hku.hk
authors.forename: Yin Bun
authors.initials: YB
authors.lastname: Cheung
authors.forename: David
authors.initials: D
authors.lastname: Machin
authors.forename: Johan
authors.initials: J
authors.lastname: Karlberg
authors.forename: Kei Siong
authors.initials: KS
authors.lastname: Khoo
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000175:diagnosis; D002648:Child; D002669:Child Welfare; D003920:Diabetes Mellitus / Q000175:diagnosis; D005260:Female; D005544:Forecasting; D006304:Health Status; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D008137:Longitudinal Studies; D008297:Male; D009369:Neoplasms / Q000175:diagnosis; D009765:Obesity / Q000175:diagnosis; D012372:ROC Curve; D012680:Sensitivity and Specificity