Toxicity of some phenolic derivatives--in vitro studies.
Cytotoxicity of 5 phenol derivatives (phenol, catechol, resorcinol, hydroquinone and phloroglucinol) was tested using a mouse 3T3 fibroblast cell line. Its relationships with structural and physicochemical properties were investigated. Linear regression analysis and Pearson's correlation coefficient were used to characterise the relationship between cytotoxicity (expressed by IC(50) values) and physicochemical parameters of compounds or their toxicity in vivo expressed by LD(50) values. The studies showed that physicochemical properties of compounds seemed to have less influence on their cytotoxic potency than structural properties. Cytotoxicity of the compounds probably depends on the number of -OH groups and their location in the aromatic ring more than on physicochemical properties of compounds. The best correlation was obtained for IC(50) values and LD(50) values determined following rabbit skin administration and experimental skin irritation score.
Zapór
Lidia
L
Department of Chemical and Aerosol Hazards, Central Institute for Labour Protection, National Research Institute, Warsaw, Poland. lizap@ciop.pl
D016475:3T3 Cells; D000818:Animals; D066298:In Vitro Techniques; D016014:Linear Models; D051379:Mice; D010636:Phenols / Q000633:toxicity*; D011817:Rabbits; D023422:Skin Irritancy Tests; D017132:Workplace
D010636:Phenols