title: Apelin signalling: a promising pathway from cloning to pharmacology.
abstract: The discovery of new signalling pathways is always followed by the development of pharmacological agents as drugs that can be used in the treatment of diseases resulting from a dysfunction of the signalling pathway in question. Apelin signalling plays a role in the central and peripheral regulation of the cardiovascular system, in water and food intake, and possibly in immune function. Up-regulation of ligand and receptor is also associated with pathophysiological states such as cardiac dysfunction and neovascularisation. Finally, the apelin receptor is a coreceptor for the entry of several HIV-1 and SIV strains. In view of these features, the apelin receptor constitutes a very interesting target for the design of new drugs for treating the prime causes of human mortality.
authors.affiliation: Unité INSERM U-589, TSA 50032, C.H.U. Rangueil, Bât. L3, 1 avenue Jean Poulhès, 31059-Toulouse Cedex 9, France.
authors.forename: B
authors.initials: B
authors.lastname: Masri
authors.forename: B
authors.initials: B
authors.lastname: Knibiehler
authors.forename: Y
authors.initials: Y
authors.lastname: Audigier
mesh_terms: D000818:Animals; D000073861:Apelin; D000075244:Apelin Receptors; D002319:Cardiovascular System / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics*; D002490:Central Nervous System / Q000502:physiology; D003001:Cloning, Molecular; D015195:Drug Design; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics*; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: C115436:APLN protein, human; C104575:APLNR protein, human; D000073861:Apelin; D000075244:Apelin Receptors; D002352:Carrier Proteins; D036341:Intercellular Signaling Peptides and Proteins; D043562:Receptors, G-Protein-Coupled