title: Hepatocellular carcinoma associated with Wilson's disease.
abstract: A 23-year-old man was admitted to our department due to hemorrhage from gastric varices. He had been diagnosed as having Wilson's disease at the age of 17. Abdominal ultrasonography and computed tomography (CT) showed portal thrombosis and a large mass occupying most of the right lobe in the liver. The tumor was diagnosed as hepatocellular carcinoma (HCC) by image views and tumor markers. He died 3 months after the diagnosis, and an autopsy was performed. Histologic examination of the tumor showed moderately to poorly differentiated HCC. The nontumorous lesion of the liver revealed cirrhosis. HBX-DNA sequence was not detected in the liver. Hepatic cirrhosis is a well-recognized complication of Wilson's disease, but HCC is extremely rare. We describe the clinical findings of this patient and discuss the relationship of the development of HCC with a review of the relevant literature.
authors.affiliation: Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima.
authors.forename: Haruyo
authors.initials: H
authors.lastname: Iwadate
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ohira
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Abe
authors.forename: Junko
authors.initials: J
authors.lastname: Yokokawa
authors.forename: Junko
authors.initials: J
authors.lastname: Takiguchi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Rai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Orikasa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Irisawa
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Obara
authors.forename: Reiji
authors.initials: R
authors.lastname: Kasukawa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000328:Adult; D001344:Autopsy; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D017809:Fatal Outcome; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D016133:Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed
chemical_list: D004273:DNA, Neoplasm