title: The value of basic science in clinical diagnosis: creating coherence among signs and symptoms.
abstract: BACKGROUND
  We investigated whether learning basic science mechanisms may have mnemonic value in helping students remember signs and symptoms, in comparison with learning the relation between symptoms and diagnoses directly.
  
  
  OBJECTIVE
  To compare 2 approaches to learning diagnosis: learning how features of various conditions relate to underlying pathophysiological mechanisms and learning the conditional probabilities of features and diseases.
  
  
  METHODS
  Undergraduate students (n = 36) were taught 4 disorders (upper motor neuron lesion, lower motor neuron lesion, neuromuscular junction disease and muscular disease), either using basic science explanations or (symptom x disease) probabilities. They were tested with diagnostic cases immediately after learning and 1 week later.
  
  
  RESULTS
  On the immediate test, there was no difference in the results. One week later, the accuracy of the mechanism group remained at 0.52, but the performance of the probability group had dropped to 0.43.
  
  
  CONCLUSIONS
  Knowledge of basic science may have value in clinical diagnosis by helping students recall or reconstruct the relationships between features and diagnoses.
authors.affiliation: Department of Psychology, McMaster University, Hamilton, Ontario L8S 4K1, Canada. woodsnn@macmaster.ca
authors.forename: Nicole N
authors.initials: NN
authors.lastname: Woods
authors.forename: Lee R
authors.initials: LR
authors.lastname: Brooks
authors.forename: Geoffrey R
authors.initials: GR
authors.lastname: Norman
mesh_terms: D002983:Clinical Competence / Q000592:standards*; D003479:Curriculum / Q000592:standards; D019937:Diagnostic Techniques and Procedures / Q000592:standards; D004504:Education, Medical, Undergraduate / Q000379:methods*; D006801:Humans; D012586:Science / Q000193:education*; D013337:Students, Medical