Autoimmune hemolytic anemia with giant cell hepatitis: case report and review of the literature.
Autoimmune hemolytic anemia (AIHA) with giant cell hepatitis (GCH) is an uncommon disease in children and is associated with an aggressive and often fatal course. The authors describe a 4-month-old girl who presented with AIHA and elevated liver enzymes. A liver biopsy was consistent with GCH. She was successfully treated with anti-CD20 antibody (rituximab)-containing therapy after failing initial immune suppression therapy. The authors also review the literature for similar cases.
Gorelik
Mark
M
Department of Pediatric Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Debski
Robert
R
Frangoul
Haydar
H
D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy* / Q000473:pathology*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D015726:Giant Cells; D006505:Hepatitis / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007223:Infant; D000069283:Rituximab; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab