Synthesis and antinociceptive activity of (5-chloro-2(3H)-benzoxazolon-3-yl) propanamide derivatives.
In this study, (5-chloro-2(3H)-benzoxazolon-3-yl)propanamide derivatives were synthesized. The chemical structures of the compounds were elucidated by their IR and 1H-NMR spectral data and microanalysis. The compounds were tested for antinociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods. The varying levels of antinociceptive activity of the compounds were compared with those of dipyrone and aspirin. Among these compounds, compound 5e, 5g, and 5h have been found to be significantly more active than the others and the standards in all the tests.
Onkol
Tijen
T
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
Sahin
M Fethi
MF
Yildirim
Engin
E
Erol
Kevser
K
Ito
Shigero
S
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D010147:Pain Measurement / Q000379:methods; D013329:Structure-Activity Relationship
C498231:(5-chloro-2(3H)-benzoxazolon-3-yl) propanamide; D000577:Amides; D000700:Analgesics; D001583:Benzoxazoles