Small RNAs and immunity.
Small RNAs of 21-23 nucleotides are powerful regulators of gene expression and play essential roles in biological processes that include development, maintenance of genome stability, and viral adaptive defense mechanisms. Such small RNAs are simple in design yet rich in biology and have captivated the attention of biologists in many fields. This review discusses the potential roles of small RNAs in immune biology and speculates on their potential participation in lymphogenesis and antiviral mechanisms.
McManus
Michael T
MT
UCSF Diabetes Center, Department of Microbiology and Immunology, University of California, San Francisco, CA 94122, USA. mmcmanus@diabetes.ucsf.edu
D000818:Animals; D001483:Base Sequence; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000276:immunology; D012333:RNA, Messenger / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D034741:RNA, Small Interfering / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D012367:RNA, Viral / Q000235:genetics / Q000276:immunology / Q000378:metabolism
D012333:RNA, Messenger; D034741:RNA, Small Interfering; D012367:RNA, Viral