Cell fate decisions in the Drosophila dorsal vessel depend on the multiadapter protein inscuteable.
The Drosophila dorsal vessel consists of two cell types, contractile cardiomyoblasts that form a linear tube-like structure, and the loosely associated pericardial cells. All heart cells originate during embryogenesis from the early dorsal mesoderm under the influence of external and internal signals. Recently, it was shown that a subset of heart cells arise throughout asymmetric cell division, dependent on the function of Notch, Sanpodo, and Numb. Here, we show that Inscuteable, a multiadapter protein required for asymmetric cell division, participates in the formation of specific heart cells to distinguish between a myogenic (cardiomyoblast) and a nonmyogenic (pericardial cell) fate.
Popichenko
Dmitry
D
Paululat
Achim
A
D000818:Animals; D002455:Cell Division; D003331:Coronary Vessels / Q000166:cytology; D003598:Cytoskeletal Proteins / Q000235:genetics* / Q000378:metabolism; D004330:Drosophila / Q000166:cytology / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology; D007150:Immunohistochemistry; D009206:Myocardium / Q000166:cytology; D009479:Neuropeptides / Q000235:genetics* / Q000378:metabolism
D003598:Cytoskeletal Proteins; D029721:Drosophila Proteins; D009479:Neuropeptides; C098678:insc protein, Drosophila