title: [Biotechnological synthesis of ribavirin. Effect of ribavirin and its various combinations on the reproduction of Vaccinia virus].
abstract: The biotechnological method of synthesis of ribavirin, vidarabin, and 6-azauridine by the use of immobilized recombinant enzymatic preparations of nucleoside phosphorylase was improved. The effect of ribavirin and its combinations with the other synthesized nucleosides on the reproduction of Vaccinia virus was studied using cultures of Vero cells. The combination of ribavirin and vidarabin was shown to provide an antiviral effect at lesser concentrations than when these compounds were taken separately. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 6; see also http://www.maik.ru.
authors.forename: I D
authors.initials: ID
authors.lastname: Konstantinova
authors.forename: N A
authors.initials: NA
authors.lastname: Leont'eva
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
authors.forename: O I
authors.initials: OI
authors.lastname: Ryzhova
authors.forename: D V
authors.initials: DV
authors.lastname: Chuvikovskiĭ
authors.forename: K V
authors.initials: KV
authors.lastname: Antonov
authors.forename: R S
authors.initials: RS
authors.lastname: Esipov
authors.forename: S A
authors.initials: SA
authors.lastname: Taran
authors.forename: K N
authors.initials: KN
authors.lastname: Verevkina
authors.forename: S A
authors.initials: SA
authors.lastname: Feofanov
authors.forename: A I
authors.initials: AI
authors.lastname: Miroshnikov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001380:Azauridine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D002384:Catalysis; D002522:Chlorocebus aethiops; D004347:Drug Interactions; D004800:Enzymes, Immobilized; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D011683:Purine-Nucleoside Phosphorylase / Q000737:chemistry; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D014543:Uridine Phosphorylase / Q000737:chemistry; D014616:Vaccinia virus / Q000187:drug effects*; D014709:Vero Cells; D014740:Vidarabine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D004800:Enzymes, Immobilized; D009705:Nucleosides; D012254:Ribavirin; D001380:Azauridine; D011683:Purine-Nucleoside Phosphorylase; D014543:Uridine Phosphorylase; D014740:Vidarabine