Preparation and evaluation of floating risedronate sodium Gelucire 39/01 matrices.
Incorporation of bisphosphonates in the lipid reduces gastric irritation. Only gastric retention with sustained release allows the drug to reach the duodenum and jejunum and improves the availability of bisphosphonates. Risedronate sodium and Gelucire 39/01 floating matrices were prepared using melt solidification. The sustained release floating matrices were evaluated for in vitro and in vivo floating ability and in vitro drug release. Ageing of the matrices was studied by differential scanning calorimetry, hot stage polarizing microscopy, scanning electron microscopy and in vitro drug release. Ageing causes changes in the crystal structure of Gelucire, which is responsible for an increase in drug release.
Chauhan
Bhaskar
B
Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandwane Pune-411038, Maharashtra, India.
Shimpi
Shyma
S
Mahadik
Kakasaheb
K
Paradkar
Anant
A
D000328:Adult; D002986:Clinical Trials as Topic / Q000379:methods; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods; D004353:Drug Evaluation, Preclinical / Q000379:methods; D012968:Etidronic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D008855:Microscopy, Electron, Scanning / Q000379:methods; D008859:Microscopy, Polarization / Q000379:methods; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011877:Radionuclide Imaging / Q000379:methods; D000068296:Risedronic Acid; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors; D014280:Triglycerides / Q000737:chemistry / Q000493:pharmacokinetics
D003692:Delayed-Action Preparations; D014280:Triglycerides; D011092:Polyethylene Glycols; D000068296:Risedronic Acid; D012968:Etidronic Acid