title: Chlamydia trachomatis and Human papillomavirus infections in cervical disease in Argentine women.
abstract: OBJECTIVE
  To examine the prevalence of Human papillomavirus and Chlamydia trachomatis DNA in cervical samples among women with normal and abnormal cervical cytology from La Plata, Argentina.
  
  
  METHODS
  Two hundred and seventy-nine women (200 with cervical neoplasia or ICC and 79 women with normal cytology) provided cervical samples for the detection of HPV and C. trachomatis DNA by PCR-based assays.
  
  
  RESULTS
  HPV DNA increased with the cervical lesion severity, ranging from 30% among women with normal cytology to 99-100% among women with HSIL or ICC. C. trachomatis DNA prevalence increased from low levels in women with normal cytology (11%) to 47% in those with HSIL, but was uncommon among ICC patients (20%). Among women with normal cytology, C. trachomatis prevalence was higher in HPV DNA positive (12.5%) than HPV DNA negative women (10.9%), but this difference was not significant.
  
  
  CONCLUSIONS
  HPV prevalence in the general population is slightly higher than those reported for other developing countries. C. trachomatis DNA positivity was associated with a higher risk of both LSIL and HSIL lesions, but not with ICC.
authors.affiliation: Centro de Investigaciones en Genética Básica y Aplicada (CIGEBA), Facultad de Ciencias Veterinarias, UNLP.Calle 60 y 118 s/n, B1900AVW, La Plata, Argentina. cgolijow@fcv.unlp.edu.ar
authors.forename: Carlos D
authors.initials: CD
authors.lastname: Golijow
authors.forename: Martín C
authors.initials: MC
authors.lastname: Abba
authors.forename: Silvana A
authors.initials: SA
authors.lastname: Mourón
authors.forename: Rubén M
authors.initials: RM
authors.lastname: Laguens
authors.forename: Fernando N
authors.initials: FN
authors.lastname: Dulout
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001118:Argentina / Q000453:epidemiology; D002690:Chlamydia Infections / Q000453:epidemiology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000235:genetics*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D002577:Uterine Cervical Diseases / Q000453:epidemiology* / Q000382:microbiology* / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000382:microbiology / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000382:microbiology / Q000821:virology
chemical_list: D004279:DNA, Viral