title: Basal cell carcinoma in childhood after radiation therapy: case report and review.
abstract: We describe 2 patients who received ionizing radiation as part of a curative regimen for childhood malignancy which later developed basal cell carcinoma at an early age. They do not occur within the context of well-defined syndromes, such like basal cell nevus syndrome, albinism, or xeroderma pigmentosum. Basal cell carcinomas appears on radiated areas in older individuals, less often in younger patients, in which the period of latency between exposure to radiation and the appearance of basal cell carcinomas is shorter than in older patients. Our 2 cases presented a period of latency of 11 and 10 years. Radiated skin areas must be explored as part of the follow-up in children who received radiotherapy and should probably be maintained for life. The basal cell carcinoma in childhood is best treated by excision.
authors.affiliation: Department of Plastic Surgery, Children's Hospital Niño Jesus, Madrid, Spain. maringutzke@yahoo.com
authors.forename: Martina
authors.initials: M
authors.lastname: Marín-Gutzke
authors.forename: Alberto
authors.initials: A
authors.lastname: Sánchez-Olaso
authors.forename: Beatriz
authors.initials: B
authors.lastname: Berenguer
authors.forename: Beatriz
authors.initials: B
authors.lastname: González
authors.forename: Pilar
authors.initials: P
authors.lastname: Rodríguez
authors.forename: Javier Enríquez
authors.initials: JE
authors.lastname: De Salamanca
authors.forename: Inmaculada
authors.initials: I
authors.lastname: De Prada
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D002280:Basal Cell Carcinoma / Q000209:etiology* / Q000601:surgery; D002675:Child, Preschool; D004806:Ependymoma / Q000188:drug therapy / Q000532:radiotherapy; D006258:Head and Neck Neoplasms / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000601:surgery; D017253:Neurofibromatoses / Q000188:drug therapy / Q000532:radiotherapy; D020339:Optic Nerve Glioma / Q000188:drug therapy / Q000532:radiotherapy; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012878:Skin Neoplasms / Q000209:etiology* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome