title: Biotransformation of hydrocortisone by a natural isolate of Nostoc muscorum.
abstract: Hydrocortisone was converted in the culture of an isolated strain of the cyanobacterium Nostoc muscorum PTCC 1636 into some androstane and pregnane derivatives. The microorganism was, isolated during a screening program from soil samples collected from paddy fields of north of Iran. The bioproducts obtained were purified using chromatographic methods and identified as 11beta-hydroxytestosterone, 11beta-hydroxyandrost-4-en-3,17-dione and 11beta,17alpha,20beta,21-tetrahydroxypregn-4-en-3-one on the basis of their spectroscopic features.
authors.affiliation: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14174, Iran. mtabataba@sina.tums.ac.ir
authors.forename: Mojtaba Tabatabaei
authors.initials: MT
authors.lastname: Yazdi
authors.forename: Homeira
authors.initials: H
authors.lastname: Arabi
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Faramarzi
authors.forename: Younes
authors.initials: Y
authors.lastname: Ghasemi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Amini
authors.forename: Shadman
authors.initials: S
authors.lastname: Shokravi
authors.forename: Farzaneh Aziz
authors.initials: FA
authors.lastname: Mohseni
mesh_terms: D000736:Androstenes / Q000302:isolation & purification*; D001711:Biotransformation; D005285:Fermentation; D006854:Hydrocortisone / Q000378:metabolism*; D015394:Molecular Structure; D046937:Nostoc / Q000378:metabolism*; D011283:Pregnenes / Q000302:isolation & purification*
chemical_list: D000736:Androstenes; D011283:Pregnenes; D006854:Hydrocortisone