title: Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient.
abstract: A 62-year-old lung transplant recipient had Fusarium proliferatum pneumonia during itraconazole prophylaxis. Severe dyspnea and emphysema ensued, requiring supplemental oxygen therapy. Therapeutic options for this patient were limited; renal insufficiency and cyclosporine use precluded amphotericin B therapy, and susceptibility testing indicated that itraconazole and fluconazole had poor activity against F proliferatum. Treatment with posaconazole, a new triazole in clinical development for the prophylaxis and treatment of fungal infection, resulted in rapid clinical improvement and successful eradication of F proliferatum. Posaconazole may provide effective treatment for difficult-to-treat Fusarium infections.
authors.affiliation: Department of Hematology and Oncology, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, 67098 Strasbourg, France. raoul.herbrecht@chru-strasbourg.fr
authors.forename: Raoul
authors.initials: R
authors.lastname: Herbrecht
authors.forename: Romain
authors.initials: R
authors.lastname: Kessler
authors.forename: Christine
authors.initials: C
authors.lastname: Kravanja
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Meyer
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Waller
authors.forename: Valérie
authors.initials: V
authors.lastname: Letscher-Bru
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D005670:Fusarium; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000188:drug therapy*; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole