Free radical theory of apoptosis and metamorphosis.
Reactive oxygen species (ROS) are the major factors that induce oxidative modification of DNA and gene mutation. ROS can elicit oxidative stress and affect a wide variety of physiological and pathological processes including embryonal development, maturation and aging.
Inoue
Masayasu
M
Department of Biochemistry & Molecular Pathology, Osaka City University Medical School, Osaka, Japan. inoue@med.osaka-cu.ac.jp
Sato
Eisuke F
EF
Nishikawa
Manabu
M
Hiramoto
Keiichi
K
Kashiwagi
Akihiko
A
Utsumi
Kozo
K
D000818:Animals; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism; D002331:Carnitine / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D002470:Cell Survival; D016572:Cyclosporine / Q000494:pharmacology; D004247:DNA / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005609:Free Radicals; D006801:Humans; D008675:Metamorphosis, Biological; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D011898:Ranidae; D017382:Reactive Oxygen Species; D013997:Time Factors; D014508:Urea / Q000378:metabolism / Q000494:pharmacology
D004791:Enzyme Inhibitors; D005609:Free Radicals; D017382:Reactive Oxygen Species; D016572:Cyclosporine; D014508:Urea; D004247:DNA; D002374:Catalase; D002331:Carnitine; D010100:Oxygen; D002118:Calcium