title: Immunologic changes to autologous transfusion after operational trauma in malignant tumor patients: neopterin and interleukin-2.
abstract: OBJECTIVE
  To estimate the impact of autologous transfusion on the status of perioperative immune activation in malignant tumor patients. The Serum Neopterin and Interleukin-2 (IL-2) were measured.
  
  
  METHODS
  Sixty patients undergoing elective radical resection for malignant stomach tumor were enrolled in the prospective study and assigned to the following groups: (1) Group A received autologous transfusion. (2) Group H received allogeneic transfusion. The perioperative course (Before induction of anesthesia, after operation and 5 d after operation) of Neopterin and IL-2 was compared.
  
  
  RESULTS
  In group A, Serum Neopterin was significantly lower than baseline after operation and IL-2 had no significant changes. In group H, both Serum Neopterin and IL-2 were significantly lower than baseline after operation and 5 d after operation. Compared with group A, Serum Neopterin was significantly lower than baseline after operation and 5 d after operation and IL-2 was significantly lower than baseline 5 d after operation.
  
  
  CONCLUSIONS
  Autologous transfusion decreased the perioperative immune suppression in malignant stomach tumor patients.
authors.affiliation: Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China. yanminnina@hotmail.com
authors.forename: Min
authors.initials: M
authors.lastname: Yan
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Ling-ling
authors.initials: LL
authors.lastname: Fang
authors.forename: Zi-ming
authors.initials: ZM
authors.lastname: Liu
authors.forename: Xiu-lai
authors.initials: XL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001804:Blood Transfusion, Autologous / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000097:blood / Q000276:immunology*; D019990:Perioperative Care / Q000009:adverse effects* / Q000379:methods; D011178:Postgastrectomy Syndromes / Q000097:blood / Q000209:etiology* / Q000276:immunology*; D013274:Stomach Neoplasms / Q000097:blood / Q000276:immunology* / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D007376:Interleukin-2; D019798:Neopterin