The structure and function of marco, a macrophage class a scavenger receptor.
The class A scavenger receptors are important in many aspects of macrophage biology. The receptor MARCO is a relatively recently described member of this class. The biological role of MARCO is under active investigation, and shows interesting similarities and contrasts to that of the class prototype, SR-A-I/II. This review surveys current knowledge and unanswered questions regarding the structure and function of the MARCO receptor.
Arredouani
M S
MS
Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA. marredou@hsph.harvard.edu
Kobzik
L
L
D000818:Animals; D006801:Humans; D008264:Macrophages / Q000502:physiology; D051379:Mice; D017434:Protein Structure, Tertiary; D011971:Receptors, Immunologic / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A
C490460:MARCO protein, human; C092228:Marco protein, mouse; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A