title: Yeast hydrolysate reduces body fat of dietary obese rats.
abstract: The purpose of this study was to assess the antiobesity effect of the yeast hydrolysate (DNF) on the body weight, body fat and plasma lipids levels of high-fat fed rats. The weight gain of the HF (high fat diet) (162.58 +/- 6.68 g) was significantly (p < 0.05) greater than that of DNF-1, DNF-2, (high fat diet with DNF of 0.5 and 1.0 g/kg body weight, respectively) and control groups (143.19 +/- 7.33 g, 139.20 +/- 8.36 g, 130.23 +/- 8.02 g, respectively). The wet weight of the epididymal fat and the perirenal fat pads of the DNF-1, DNF-2 and control groups were reduced significantly (p < 0.05). A significant (p < 0.05) increase of HDL-cholesterol level of the DNF-2 and control groups was observed. However, there was no significant difference between DNF-1 and DNF-2. It was also found that the triacylglycerol (TG) levels decreased significantly (p < 0.05) in the DNF-2 group from that of the HF, but there was no significant (p < 0.05) difference between DNF-1 and DNF-2.
authors.affiliation: Department of Food and Nutrition, College of Health Sciences, Korea University, 1 Jeongneung-dong, Sungbuk-ku, Seoul 136-703, Korea.
authors.forename: K M
authors.initials: KM
authors.lastname: Kim
authors.forename: U J
authors.initials: UJ
authors.lastname: Chang
authors.forename: D H
authors.initials: DH
authors.lastname: Kang
authors.forename: J M
authors.initials: JM
authors.lastname: Kim
authors.forename: Y M
authors.initials: YM
authors.lastname: Choi
authors.forename: H J
authors.initials: HJ
authors.lastname: Suh
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D004041:Dietary Fats; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009765:Obesity / Q000097:blood / Q000188:drug therapy*; D008517:Phytotherapy; D011492:Protein Hydrolysates / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood; D015003:Yeasts
chemical_list: D008076:Cholesterol, HDL; D004041:Dietary Fats; D000960:Hypolipidemic Agents; D011492:Protein Hydrolysates; D014280:Triglycerides; D002784:Cholesterol