Comparative clinical study of cefcapene pivoxil and cefteram pivoxil in chronic respiratory tract infections by a double-blind method.
In a double-blind study, the efficacy and safety of the novel cephem antibiotic cefcapene pivoxil (CFPN-PI; 450 mg/day) was compared with cefteram pivoxil (CFTM-PI; 600 mg/day) in 171 patients with chronic respiratory tract infections. There was no significant difference between the clinical efficacy of the two drugs (80.2% for CFPN-PI versus 78.9% for CFTM-PI). There was no significant difference in the rate of elimination of the causative bacteria (60.5% for CFPN-PI versus 65.9% for CFTM-PI). Side-effects were observed in 6.0% of patients treated with CFPN-PI compared with 6.4% of patients treated with CFTM-PI. There were no significant differences in incidence of abnormal laboratory findings following treatment with the two drugs (13.9% for each), and none of the side-effects was severe. We conclude that CFPN-PI (450 mg/day) was as effective and as well tolerated as CFTM-PI (600 mg/day) in the treatment of chronic respiratory tract infections.
Saito
A
A
First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Hiraga
Y
Y
Watanabe
A
A
Saito
A
A
Shimada
K
K
Kobayashi
H
H
Odagiri
S
S
Miki
F
F
Soejima
R
R
Oizumi
K
K
Hara
K
K
Nakashima
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000378:metabolism; D001424:Bacterial Infections / Q000188:drug therapy; D001831:Body Temperature; D015281:Cefmenoxime / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008956:Models, Chemical; D010919:Placebos; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010919:Placebos; C046817:cefteram pivoxil; C425944:cefcapene pivoxil hydrochloride; D015281:Cefmenoxime