Topiramate reduces levodopa-induced dyskinesia in the MPTP-lesioned marmoset model of Parkinson's disease.
Overactive AMPA receptor-mediated transmission may be involved in the pathogenesis of levodopa-induced dyskinesia. The mechanism of action of the anticonvulsant drug topiramate involves attenuation of AMPA receptor-mediated transmission. In this study, the potential antidyskinetic action of topiramate was examined in the MPTP-lesioned marmoset model of Parkinson's disease and levodopa-induced dyskinesia. Topiramate significantly reduced levodopa-induced dyskinesia, without affecting the antiparkinsonian action of levodopa. Topiramate represents an exciting potential novel therapeutic approach to levodopa-induced dyskinesia in patients with Parkinson's disease.
Silverdale
Monty A
MA
Department of Neurology, Hope Hospital, Salford, Manchester, United Kingdom.|Manchester Movement Disorder Laboratory, School of Biological Science, University of Manchester, Manchester, United Kingdom.
Nicholson
S L
SL
Manchester Movement Disorder Laboratory, School of Biological Science, University of Manchester, Manchester, United Kingdom.
Crossman
A R
AR
Manchester Movement Disorder Laboratory, School of Biological Science, University of Manchester, Manchester, United Kingdom.|Motac Neuroscience Ltd., Williams House, Manchester Science Park, Manchester, United Kingdom.
Brotchie
J M
JM
Toronto Western Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada.
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002144:Callithrix; D004195:Disease Models, Animal; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000209:etiology*; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use*; D020267:MPTP Poisoning / Q000150:complications*; D010300:Parkinson Disease / Q000188:drug therapy*; D000077236:Topiramate
D000927:Anticonvulsants; D000978:Antiparkinson Agents; D000077236:Topiramate; D005632:Fructose; D007980:Levodopa