Familial gigantiform cementoma with brittle bone disease, pathologic fractures, and osteosarcoma: a possible explanation of an ancient mystery.
We describe four individuals of an African-American family with a predominantly diaphyseal bone disease associated with familial gigantiform cementoma (FGC), a disorder typically seen in Caucasians. The mother and her children presented with deformities of the jaws, abnormalities of the long bones, and pre-pubertal pathologic fractures. The index patient carried the diagnosis of osteosarcoma (OS). In addition, we provide a possible explanation for the jaw abnormalities of King Tutankhamen's father in the 18th dynasty in Egypt around 1350 BC.
Rossbach
Hans-Christoph
HC
Division of Pediatric Hematology/Oncology, All Children's Hospital, St. Petersburg, Florida, USA. hanschristoph.rossbach@baycare.org
Letson
Douglas
D
Lacson
Atilano
A
Ruas
Ernesto
E
Salazar
Peter
P
D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology*; D002485:Cementoma / Q000150:complications* / Q000235:genetics / Q000266:history / Q000473:pathology; D002648:Child; D000076144:Egypt, Ancient; D005192:Family Health; D005260:Female; D049690:History, Ancient; D006801:Humans; D007573:Jaw Neoplasms / Q000150:complications* / Q000235:genetics / Q000266:history / Q000473:pathology; D008297:Male; D016609:Neoplasms, Second Primary; D010009:Osteochondrodysplasias / Q000150:complications* / Q000235:genetics; D012516:Osteosarcoma / Q000473:pathology*