title: [Matrix metalloproteinases, C-reactive protein, and markers of thrombinemia in patients with stable angina and restenoses after percutaneous coronary interventions.].
abstract: OBJECTIVE
  To elucidate relationships between blood levels of matric metalloproteinases (MMP), C-reactive protein (CRP), markers of thrombinemia, and development of restenosis after percutaneous coronary interventions (PCI) in patients with stable angina.
  
  
  METHODS
  Patients (n=78, mean age 55.7+/-0.9 years) after successful PCI.
  
  
  METHODS
  MMP-2, MMP-9, CRP, prothrombin fragments 1 and 2, thrombin-antithrombin complex and plasminogen activator inhibitor antigen were measured in blood plasma taken before PCI. Repeat coronary angiography was carried out in 31 patients 6-8 months after PCI. Exercise ECG was used for diagnosis of restenosis in other patients. More than 1 mm ST depression in same ECG leads as before PCI was used as criterion of restenosis.
  
  
  RESULTS
  Overall sings of restenosis were found in 28 patients (35.9%). Patients with and without restenosis had similar contents of prothrombin fragments 1 and 2, thrombin-antithrombin complex, plasminogen activator inhibitor antigen and CRP, while patients with restenosis had significantly higher levels of MMP 2 and 9 (r<0.05). At multifactorial analysis level of MMP-9 was independently related to development of restenosis.
  
  
  CONCLUSIONS
  Elevated level of MP-9 has predictive value in relation to development of restenosis.
authors.affiliation: Cardiology Research Complex; ul. Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Zemlianskaia
authors.forename: E P
authors.initials: EP
authors.lastname: Panchenko
authors.forename: A N
authors.initials: AN
authors.lastname: Samko
authors.forename: A B
authors.initials: AB
authors.lastname: Dobrovol'skiĭ
authors.forename: I V
authors.initials: IV
authors.lastname: Levitskiĭ
authors.forename: V P
authors.initials: VP
authors.lastname: Masenko
authors.forename: E V
authors.initials: EV
authors.lastname: Titaeva
mesh_terms: D060050:Angina, Stable; D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein; D023903:Coronary Restenosis / Q000175:diagnosis; D006801:Humans; D020782:Matrix Metalloproteinases; D062645:Percutaneous Coronary Intervention
chemical_list: D002097:C-Reactive Protein; D020782:Matrix Metalloproteinases