[Acute coronary syndrome and inflammation. Biomarkers for diagnostics and risk stratification].
Inflammation plays a pivotal role in atherosclerosis and coronary heart disease. Inflammatory processes of the coronary arterial wall are involved in plaque formation, progression and, finally, plaque instability consecutively leading to the clinical manifestations of stable coronary artery disease or acute coronary syndromes (unstable angina, non-ST elevation and ST elevation myocardial infarction). Acute coronary syndromes result from plaque rupture or erosion leading to local thrombus formation with consecutive necrosis of myocytes due to ischemia, which is associated with widespread and diffuse pancoronary and panmyocardial inflammation. Accordingly, markers of myocardial necrosis (e. g., cardiac troponins) do have crucial diagnostic and prognostic value. In case of troponin-negative acute coronary syndromes, however, markers of inflammation emerged as potentially useful tools for risk stratification. C-reactive protein has been shown to serve as a powerful predictor of future cardiovascular events following acute coronary syndromes, even if troponins are not (yet) positive. Moreover, a variety of pro- (soluble CD40 ligand, placental growth factor, interleukin-6, pregnancy-associated plasma protein A, myeloperoxidase, monocyte chemoattractant protein-1) and anti-inflammatory markers (interleukin-10, activin A) have been suggested to provide relevant prognostic information in patients with acute coronary syndrome. However, the clinical utility of these novel markers has not been established so far.
Trepels
Thomas
T
Medizinische Klinik IV, Kardiologie, Klinikum der Johann-Wolfgang-Goethe-Universität, Frankfurt am Main.
Zeiher
Andreas M
AM
Fichtlscherer
Stephan
S
D000208:Acute Disease; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D016207:Cytokines / Q000032:analysis / Q000097:blood* / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D010818:Practice Patterns, Physicians'; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013577:Syndrome; D014336:Troponin / Q000097:blood* / Q000276:immunology; D014657:Vasculitis / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000276:immunology
D015415:Biomarkers; D016207:Cytokines; D014336:Troponin