title: Systemic inflammatory mediators contribute to widespread effects in work-related musculoskeletal disorders.
abstract: Recent studies in a rat model have indicated that the pathophysiological mechanisms underlying development of work-related musculoskeletal disorders (WMSDs) include widespread inflammation and subsequent fibrosis at high levels of repetition and force. A systemic inflammatory component may affect tissues not directly involved in task performance, thereby contributing to widespread and puzzling symptoms that are often characteristic of patients with WMSDs.
authors.affiliation: Physical Therapy Department, College of Health Professions, Temple University, Philadelphia, PA, USA. aebarr@temple.edu
authors.forename: Ann E
authors.initials: AE
authors.lastname: Barr
authors.forename: Mary F
authors.initials: MF
authors.lastname: Barbe
authors.forename: Brian D
authors.initials: BD
authors.lastname: Clark
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D012090:Cumulative Trauma Disorders / Q000378:metabolism / Q000503:physiopathology*; D016207:Cytokines / Q000097:blood / Q000276:immunology; D005552:Forelimb / Q000293:injuries; D006614:Hindlimb / Q000293:injuries; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D023421:Models, Animal; D018482:Muscle, Skeletal / Q000293:injuries; D009140:Musculoskeletal Diseases / Q000378:metabolism / Q000503:physiopathology*; D009784:Occupational Diseases / Q000378:metabolism / Q000503:physiopathology*; D059348:Peripheral Nerve Injuries; D051381:Rats; D018746:Systemic Inflammatory Response Syndrome / Q000378:metabolism / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators