Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster.
The insulin signaling pathway regulates multiple physiological processes, including energy metabolism, organismal growth, aging and reproduction. Here we show that genetic manipulations in Drosophila melanogaster that impair the function of insulin-producing cells or of the insulin-receptor signaling pathway in the nervous system lead to increased sensitivity to the intoxicating effects of ethanol. These findings suggest a previously unknown role for this highly conserved pathway in regulating the behavioral responses to an addictive drug.
Corl
Ammon B
AB
Department of Anatomy and Programs, University of California, San Francisco, California 94143-2822, USA.
Rodan
Aylin R
AR
Heberlein
Ulrike
U
D000435:Alcoholic Intoxication / Q000209:etiology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D007328:Insulin / Q000096:biosynthesis / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction
D007328:Insulin; D000431:Ethanol; D011972:Receptor, Insulin