title: [Effect of saikosaponins on epileptic rat electroenciphalogram].
abstract: OBJECTIVE
  To study the effect of saikosaponins on the electroencephalogram (EEG) of epileptic rats to evaluate its therapeutic effect against epilepsies.
  
  
  METHODS
  Sixty 8-week-old healthy SD rats were randomized into normal control group (A), epileptic model group (B), lamotrigine group (C), and 3 saikosaponin groups of small, moderate and high doses (D, E, and F groups, respectively), with 10 rats in each group. Penicillin was used to induce epilepsy in the latter 5 groups, and the EEG and onset of epileptic seizures were observed in each group.
  
  
  RESULTS
  In group B, the EEG contained obvious epileptic discharges, which were not found in that in group A. After treatment with saikosaponins and lamotrignie, the EEG of group C and F became normal, whereas the EEG in group D still contained epileptic discharges at a low level, and that in group E was basically normal. The EEGs of group C, D, E, and F were significantly different from that in group B (P<0.001).
  
  
  CONCLUSIONS
  Saikosaponins can obviously alleviate the severity of epileptic seizure in epileptic rats.
authors.affiliation: Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. hnhys2002@yahoo.com.cn
authors.forename: Yun-sheng
authors.initials: YS
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Xie
authors.forename: Bao-tian
authors.initials: BT
authors.lastname: Chen
mesh_terms: D000818:Animals; D004569:Electroencephalography / Q000187:drug effects*; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D012503:Saponins; D009828:Oleanolic Acid; C025759:saikosaponin D