[Search for HHV-8 associated diseases reservoir and spread paths of HHV-8 in Russia].
Summarized in the paper are study results of human herpesvirus type 8 (HHV-8) and of its association with Kaposi's sarcoma (KS). The data obtained denotes that the share of individuals producing the antibodies to HHV-8 in a majority of studied patients was low and ranged form 0 to 5.5%, which is indicative of a low degree of the virus spread in population. At the same time, a high share of persons with antibodies to HHV-8 was detected among HIV-infected homosexuals (71.4%), kidney recipients (26.0%) and among AIDS-KS patients (78.6%). It was also unexpectedly high among patients with T- and B-cell lymphomas (50%), encephalopathy (27.3%) and with stomach cancer (41.8%): the appropriate parameters were 7-12-fold higher versus healthy subjects. The HHV-8 markers, i.e. virus specific antibodies and/or nucleotide sequences of the virus, were detected in blood serum and ejaculate of a significant number of patients with different pathologies of the prostate. Such detection of viral markers in the above categories of patients is suggestive of that sexual contacts with such patients are decisive for the HHV-8 spread in population.
Gurtsevich
V E
VE
Kadyrova
E L
EL
Chernova
V A
VA
Demidov
L V
LV
Gruzdev
B M
BM
Gessain
A
A
Iakovleva
L S
LS
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications; D000914:Antibodies, Viral / Q000097:blood*; D004197:Disease Reservoirs; D018562:Disease Transmission, Infectious; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications; D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000209:etiology / Q000635:transmission*; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006716:Homosexuality; D006801:Humans; D008223:Lymphoma / Q000097:blood / Q000150:complications; D008297:Male; D011183:Postoperative Complications / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000821:virology; D011472:Prostatitis / Q000097:blood / Q000821:virology; D012426:Russia; D012514:Sarcoma, Kaposi / Q000097:blood / Q000150:complications; D012661:Semen / Q000821:virology; D016036:Seroepidemiologic Studies; D013274:Stomach Neoplasms / Q000097:blood / Q000150:complications
D000914:Antibodies, Viral