Direct intramolecular arylation of unactivated arenes: application to the synthesis of aporphine alkaloids.
The direct intramolecular C-H arylation of unactivated arenes is a viable strategy for the synthesis of aporphine alkaloids. These reactions occur with 3 to 5 mol% catalyst and generate the aporphine skeleton in up to 99% yield.
Lafrance
Marc
M
Center for Catalysis Research and Innovation, University of Ottawa, Department of Chemistry, 10 Marie Curie, Ottawa, Canada K1N 6N5.
Blaquière
Nicole
N
Fagnou
Keith
K
D001060:Aporphines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012997:Solvents; D013696:Temperature
D001060:Aporphines; D012997:Solvents