Three novel single nucleotide polymorphisms in UGT1A10.
Three novel single nucleotide polymorphisms (SNPs) were found in the UDP-glucuronosyltransferase (UGT) 1A10 gene from 24 Japanese patients with various cancers who were administered the anti-tumor drug, irinotecan (CPT-11). The detected SNPs were as follows: 1) SNP, MPJ6_U1A003; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-CAGATGCCATGAC/TTTTCAAGGAGAG-3'. 2) SNP, MPJ6_U1A004; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-CCTAGAAATAGCC/TTCTGAAATTCTC-3'. 3) SNP, MPJ6_U1A030; GENE NAME, UGT1A10; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-GGTTGTAGTCATG/ACCAGAGGTGAGT-3' All the three SNPs were located in exon 1 and their frequencies were all 0.021. Among these SNPs, MPJ6_U1A003 and U1A030 resulted in amino acid alterations, T202I and M59I, respectively. The third SNP, MPJ6_U1A004, introduced a synonymous amino acid change (A231A).
Saeki
Mayumi
M
Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan.
Ozawa
Shogo
S
Saito
Yoshiro
Y
Jinno
Hideto
H
Hamaguchi
Tetsuya
T
Nokihara
Hiroshi
H
Shimada
Yasuhiro
Y
Kunitoh
Hideo
H
Yamamoto
Noboru
N
Ohe
Yuichiro
Y
Yamada
Yasuhide
Y
Shirao
Kuniaki
K
Muto
Manabu
M
Mera
Kiyomi
K
Goto
Koichi
K
Ohmatsu
Hironobu
H
Kubota
Kaoru
K
Niho
Seiji
S
Kakinuma
Ryutaro
R
Minami
Hironobu
H
Ohtsu
Atsushi
A
Yoshida
Teruhiko
T
Saijo
Nagahiro
N
Sawada
Jun-ichi
J