T-cell sinonasal lymphoma presenting as acute orbit with extraocular muscle infiltration.
We describe a rare case of sinonasal T-cell lymphoma in an 11-year-old boy who presented with a right acute orbit characterized by proptosis, eyelid edema and erythema, limitation of eye movements, and excruciating pain on the right side of his face. Orbital computed tomography showed progressive right extraocular muscle enlargement. One biopsy specimen showed extensive tissue necrosis and an infiltrate of atypical cells with pleomorphic nuclei within the walls of blood vessels. Immunohistochemical studies demonstrated that these cells were positive for leucocyte common antigen (CD45), CD3 cytoplasmic, CD45RO, and terminal deoxynucleotidyl transferase and negative for CD20, CD57, CD56, CD99 and Epstein-Barr virus. Chemotherapy for T-cell non-Hodgkin lymphoma was initiated, but the patient's status deteriorated and the child died of respiratory insufficiency, sepsis, and central nervous system infection.
Cruz
Antonio Augusto V
AA
Department of Ophthalmology, Otorhinolaryngology, and Head and Neck, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. aavecruz@fmrp.usp.br
Leite
Lívio Viana de Oliveira
LV
Chahud
Fernando
F
Neder
Luciano
L
Tone
Luiz Gonzaga
LG
Valera
Elvis Terci
ET
Elias
Jorge
J
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D017809:Fatal Outcome; D006801:Humans; D016399:Lymphoma, T-Cell / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009361:Neoplasm Invasiveness; D009801:Oculomotor Muscles / Q000000981:diagnostic imaging / Q000473:pathology*; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents