Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones.
In the reaction of hydrazide of thiophene-2-acetic acid (1) with isothiocyanates, the respective thiosemicarbazides 2a-g were obtained. Further cyclization with 2% NaOH led to formation of 4-substituted-3-(thiophene- 2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones (3a-g). These compounds showed promising antimycotic activity.
Wujec
Monika
M
Department of Organic Chemistry, Faculty of Pharmacy, Medical University Lublin, Poland.
Pitucha
Monika
M
Dobosz
Maria
M
Kosikowska
Urszula
U
Malm
Anna
A
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D006834:Hydrazines / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods; D015394:Molecular Structure; D021281:Quantitative Structure-Activity Relationship; D012663:Semicarbazides / Q000138:chemical synthesis / Q000494:pharmacology; D013678:Technology, Pharmaceutical / Q000379:methods; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology*; D013876:Thiophenes / Q000138:chemical synthesis / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000935:Antifungal Agents; D006834:Hydrazines; D012663:Semicarbazides; D013871:Thiones; D013876:Thiophenes; D014230:Triazoles; C045575:1,2,4-triazole; C005151:thiosemicarbazide