Thrombotic microangiopathy with liver, gut, and bone infarction (catastrophic antiphospholipid syndrome) associated with HELLP syndrome.
Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is a thrombotic microangiopathy complicating pregnancy and shares many clinical and biological features with thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Thrombotic microangiopathy is also a pathological feature of catastrophic antiphospholipid syndrome (CAPS). An association between refractory HELLP syndrome and antiphospholipid syndrome (APS) has been reported in a few cases. We describe a 19-year-old woman with APS and multiorgan failure conforming to a diagnosis of CAPS who developed refractory HELLP syndrome.
Koenig
Martial
M
Department of Internal Medicine, Hôpital Nord, CHU Saint-Etienne, 42055 Saint-Etienne Cedex 2, France. martial.koenig@chu-st-etienne.fr
Roy
Michel
M
Baccot
Sylviane
S
Cuilleron
Muriel
M
de Filippis
Jean-Pierre
JP
Cathébras
Pascal
P
D000293:Adolescent; D001842:Bone and Bones / Q000098:blood supply / Q000473:pathology; D005260:Female; D017359:HELLP Syndrome / Q000150:complications*; D006801:Humans; D007238:Infarction / Q000209:etiology* / Q000473:pathology*; D007422:Intestines / Q000098:blood supply / Q000473:pathology; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008833:Microcirculation; D011247:Pregnancy; D013927:Thrombosis / Q000209:etiology* / Q000473:pathology*