[Expression and correlation of C-met and estrogen receptor in endometrial carcinomas].
OBJECTIVE
To investigate the expression and correlation of C-met and Estrogen receptor (ER) in endometrial carcinomas.


METHODS
We examined 55 samples of endometrial carcinomas using specific polyclonal endometrial carcinomas.


METHODS
antibody and monoclonal antibody correspondent to the human C-met and ER respectively. The histochemical score was estimated according to the formula H = (i + 1) x pi, with a criterion of equal or more than 70 as considered to be positive in expression.


RESULTS
The expression of C-met was correlated with both histological grade and clinical stage of endometrial carcinomas. The H scores of carcinomas in grade 3 was higher than in grade 1 and grade 2, while higher H scores were found in carcinomas in stage III and II compared to stage I (P < 0.05). The higher of the grade and stage were, the weaker the ER were expressed in endometrial carcinomas (P < 0.05). There was an inverse correlation between the expression of ER and C-met (r = -0.5842 P < 0.05).


CONCLUSIONS
The expression of C-met and ER might be a useful predictor for the prognosis of endometrial carcinomas and an indicator to evaluate the effectiveness of the hormone intervention.
He
Yuedong
Y
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Peng
Zhilan
Z
Pan
Xiaoling
X
Wang
He
H
Ouyang
Yunwei
Y
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019859:Proto-Oncogene Proteins c-met / Q000096:biosynthesis* / Q000235:genetics; D011960:Receptors, Estrogen / Q000096:biosynthesis* / Q000235:genetics
D011960:Receptors, Estrogen; D019859:Proto-Oncogene Proteins c-met