[Correlation between intravascular coagulation/fibrinolysis system and cytokines].
Bacterial factors stimulate the release of tissue factor as well as proinflammatory and antiinflammatory cytokines. TNF augments inflammation, TNF and IFN-gamma induce coagulation, and IL-1beta induces coagulation and fibrinolysis. IL-8 augments synergistic inflammation and coagulation. IL-6 augments coagulation and inhibits fibrinolysis. IL-10 inhibits inflammatory process and inhibits fibrinolysis. IL-4, IL-13, and TGF-beta act for anticoagulation. Administration of IL-2, G-CSF or IFN-gamma has been reported to have side effect of induction of coagulation. IL-12 induces coagulation first and fibrinolysis later. On the other, tissue factor induces proinflammatory (except TNF) and antiinflammatory cytokines, and thrombin enhances inflammation. Patients who died of SIRS/sepsis have been complicated with hypercoagulopathy and impaired fibrinolysis correlated with increased IL-10 production. Inhibition of IL-10 production or administration of fiblynolitic agents may be useful. Recently, activated protein C (APC) which has antiinflammatory effect has been paid attention in the treatment of SIRS/sepsis.
Shinozawa
Yotaro
Y
Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Tohoku University.
Xie
Xiao Qi
XQ
Endo
Tomoyuki
T
Takuma
Kiyotsugu
K
Koike
Kaoru
K
D000368:Aged; D001777:Blood Coagulation / Q000502:physiology*; D016207:Cytokines / Q000502:physiology*; D004211:Disseminated Intravascular Coagulation / Q000503:physiopathology; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D018805:Sepsis / Q000503:physiopathology
D016207:Cytokines