Novel adamantylated pyrimidines and their preliminary biological evaluations.
The synthesis of adamantylated pyrimidines was based on the reaction of 3-(adamantan-1-yl)-3-oxopropionic acid ethyl ester with urea, thiourea, guanidine as well as acetamidine, respectively. Then the compounds obtained were converted into respective bromo-, thio- and S-alkyl derivatives. The molecular structures for some compounds were studied by X-ray methods. The significant anticancer and antimicrobial properties of [2-(6-adamantan-1-yl-2-methylpyrimidin-4-ylthio)ethyl]dimethylamine were found.
Orzeszko
Barbara
B
Faculty of Chemistry, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw, Poland. orzeszkoa@delta.sggw.waw.pl
Kazimierczuk
Zygmunt
Z
Maurin
Jan Krzysztof
JK
Laudy
Agnieszka Ewa
AE
Starościak
Bohdan Jerzy
BJ
Vilpo
Juhani
J
Vilpo
Leena
L
Balzarini
Jan
J
Orzeszko
Andrzej
A
D000218:Adamantane; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011743:Pyrimidines; D000218:Adamantane