title: Clinical trial experience with fat-restricted vs. carbohydrate-restricted weight-loss diets.
abstract: It is unlikely that one diet is optimal for all overweight or obese persons. Both low-fat and low-carbohydrate diets have been shown to induce weight loss and reduce obesity-related comorbidities. Low-carbohydrate diets cause greater short-term (up to 6 months) weight loss than low-fat diets, but the long-term clinical safety and efficacy of these diets has not been studied.
authors.affiliation: Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110-1093, USA. sklein@imgate.wustl.edu
authors.forename: Samuel
authors.initials: S
authors.lastname: Klein
mesh_terms: D001823:Body Composition; D002986:Clinical Trials as Topic; D004032:Diet; D018752:Diet, Fat-Restricted; D004038:Diet, Reducing; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D002149:Energy Intake; D004734:Energy Metabolism; D006801:Humans; D008055:Lipids / Q000097:blood; D009765:Obesity / Q000178:diet therapy*; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D015431:Weight Loss
chemical_list: D004040:Dietary Carbohydrates; D008055:Lipids