title: Long-term follow-up of a patient with idiopathic myelofibrosis associated with chromosome 11 and 13 abnormalities.
abstract: A case of a leukemic transformation following a 27-year history of idiopathic myelofibrosis (IMF) is presented. The patient had two chromosomal abnormalities: a deletion of chromosome 13, del 13(q12q14), and a deletion of chromosome 11, del 11(q14q23). This patient's final diagnosis was acute micromegakaryocytic leukemia, and she died 1 month after leukemic transformation with an additional chromosomal abnormality, trisomy 8. IMF with myeloid metaplasia associated with deletion of the long arms of chromosomes 11 and 13 has not been previously reported. We speculate that the leukemic transformation in this patient was associated with chromosomal abnormalities del 11 and trisomy 8.
authors.affiliation: Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. ttoubai@hkg.odn.ne.jp
authors.forename: Tomomi
authors.initials: T
authors.lastname: Toubai
authors.forename: Junji
authors.initials: J
authors.lastname: Tanaka
authors.forename: Toshio
authors.initials: T
authors.lastname: Higa
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ota
authors.forename: Makoto
authors.initials: M
authors.lastname: Ibata
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shono
authors.forename: Shinobu
authors.initials: S
authors.lastname: Mashiko
authors.forename: Yoko
authors.initials: Y
authors.lastname: Miura
authors.forename: Shintaro
authors.initials: S
authors.lastname: Umehara
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kahata
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Toyoshima
authors.forename: Masanobu
authors.initials: M
authors.lastname: Morioka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
authors.forename: Masaharu
authors.initials: M
authors.lastname: Kasai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Imamura
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D017353:Gene Deletion; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000097:blood / Q000235:genetics* / Q000473:pathology; D014314:Trisomy / Q000235:genetics