Increased level of polymerase III transcribed Alu RNA in hepatocellular carcinoma tissue.
There have been extensive observations that RNA containing repetitive elements accumulates in transformed cells and tumor tissues. In the present study, we first obtained result consistent with previous observations by in situ hybridization. Then we used primer extension analysis to determine the level of polymerase III directed Alu RNA and found an increased expression of Alu RNA in hepatocellular carcinoma.
Tang
Rui-Bao
RB
Department of Histology and Embryology, the Second Military Medical University, Shanghai 200433, China.
Wang
Hong-Yang
HY
Lu
Hai-Ying
HY
Xiong
Jun
J
Li
Hong-Hua
HH
Qiu
Xiu-Hua
XH
Liu
Hou-Qi
HQ
D020087:Alu Elements; D006528:Carcinoma, Hepatocellular / Q000201:enzymology* / Q000235:genetics*; D017931:DNA Primers / Q000737:chemistry; D006801:Humans; D017403:In Situ Hybridization; D008113:Liver Neoplasms / Q000201:enzymology* / Q000235:genetics*; D008969:Molecular Sequence Data; D012313:RNA / Q000378:metabolism; D012320:RNA Polymerase III / Q000378:metabolism / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic
D017931:DNA Primers; D012333:RNA, Messenger; D012313:RNA; D012320:RNA Polymerase III