An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients.
We have compared plasma redox status of coenzyme Q-10 in 20 sporadic amyotrophic lateral sclerosis (sALS) patients with those in 20 healthy age/sex-matched controls. A significant increase in the oxidized form of coenzyme Q-10 (sALS=109.3+/-95.2 nM; controls=23.3+/-7.5 nM, P=0.0002) and in the ratio of oxidized form of coenzyme Q-10 to total coenzyme Q-10 (%CoQ-10) (sALS=12.0+/-9.3%; controls=3.2+/-0.9%, P<0.0001) were observed. Moreover, %CoQ-10 correlated significantly with the duration of illness (rho=0.494, P=0.0315). Our finding suggests systemic oxidative stress in the pathogenesis of sALS.
Sohmiya
Makoto
M
Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan. sohmiyam@med.gunma-u.ac.jp
Tanaka
Makoto
M
Suzuki
Yoko
Y
Tanino
Yutaka
Y
Okamoto
Koichi
K
Yamamoto
Yorihiro
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D001205:Ascorbic Acid / Q000097:blood; D001663:Bilirubin / Q000097:blood; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003067:Coenzymes; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018709:Statistics, Nonparametric; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism*; D014527:Uric Acid / Q000097:blood
D003067:Coenzymes; D014451:Ubiquinone; D014527:Uric Acid; C024989:coenzyme Q10; D001205:Ascorbic Acid; D001663:Bilirubin