Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis.
Aspergillus fumigatus causes invasive pulmonary aspergillosis (IPA). This disease is one of the most life-threatening opportunistic infections in immunocompromised patients. The type of immunosuppressive regimen under which IPA occurs has rarely been investigated. In this study, we evaluated various parameters of the innate immune response during the progression of murine IPA induced by the intratracheal administration of A. fumigatus conidia as a function of two immunosuppressive treatments: a corticosteroid and a chemotherapeutic agent. We compared host responses various times after infection in terms of survival, pulmonary production of pro- and anti-inflammatory cytokines, cellular trafficking in the airways, lung injury, respiratory distress, and fungal development. We found that IPA pathogenesis involved predominantly fungal development in mice treated by chemotherapy and an adverse host response in mice treated with a corticosteroid. These previously unrecognized differences should be taken into account in evaluations of the pathogenesis of IPA in animal models.
Balloy
Viviane
V
Unité de Défense Innée et Inflammation, INSERM E336, Institut Pasteur, 25 Rue du Dr. Roux, 75015 Paris, France.
Huerre
Michel
M
Latgé
Jean-Paul
JP
Chignard
Michel
M
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001228:Aspergillosis / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D001232:Aspergillus fumigatus; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002686:Chitin / Q000032:analysis; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology*; D016753:Interleukin-10 / Q000032:analysis; D008168:Lung / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009894:Opportunistic Infections / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002686:Chitin