title: Association between human alpha 2-Heremans Schmidt glycoprotein (AHSG) polymorphism and endometriosis in Korean women.
abstract: OBJECTIVE
  To evaluate the relationship between the alpha 2-Heremans Schmidt glycoprotein (AHSG) gene polymorphism and endometriosis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Department of Obstetrics and Gynecology, Seoul National University Hospital, Korea.
  
  
  METHODS
  Seventy-nine women with endometriosis and 105 women without endometriosis.
  
  
  METHODS
  Determination of AHSG gene polymorphism.
  
  
  METHODS
  Prevalence of AHSG genotypes or alleles.
  
  
  RESULTS
  The allele frequencies of AHSG 1 and AHSG 2 were found to be 0.69 and 0.31, respectively. The proportion of noncarriers of the AHSG 2 allele was significantly higher in women with endometriosis than in women without (55.7% vs. 39.0%). Women not carrying the AHSG 2 allele were found to have twice the risk of endometriosis than those carrying at least one copy of this allele. No significant difference was noted in the distribution of the AHSG alleles or AHSG genotypes between early stage endometriosis and late stage endometriosis.
  
  
  CONCLUSIONS
  Endometriosis is associated with the AHSG gene polymorphism in Korean women.
authors.affiliation: Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. kimjg@plaza.snu.ac.kr
authors.forename: Jung Gu
authors.initials: JG
authors.lastname: Kim
authors.forename: Hoon
authors.initials: H
authors.lastname: Kim
authors.forename: Seung-Yup
authors.initials: SY
authors.lastname: Ku
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001798:Blood Proteins / Q000235:genetics*; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D060749:alpha-2-HS-Glycoprotein
chemical_list: C556354:AHSG protein, human; D001798:Blood Proteins; D060749:alpha-2-HS-Glycoprotein