title: Ulcerative colitis occurring in the course of rheumatoid arthritis: a case successfully treated with mesalamine enema.
abstract: We report a case of ulcerative colitis (UC) that occurred during the course of rheumatoid arthritis (RA). A 29-year-old woman with a 25-year history of RA was hospitalized for high fever, abdominal pain and hematochezia. Colonoscopy revealed erosive and reddish mucosa from the distal transverse colon to rectum. Histology revealed cryptitis (mainly caused by neutrophils), mild crypt abscess and goblet cell depletion. She was diagnosed with left-sided UC and treated with mesalamine enema. The abdominal symptoms and colonoscopic findings were greatly ameliorated. We conclude that the mesalamine enema was effective in this case of UC occurring during the course of RA.
authors.affiliation: Fukushima Medical University School of Medicine, Fukushima.
authors.forename: Kota
authors.initials: K
authors.lastname: Sugisaki
authors.forename: Fumiko
authors.initials: F
authors.lastname: Honma
authors.forename: Haruyo
authors.initials: H
authors.lastname: Iwadate
authors.forename: Kiori
authors.initials: K
authors.lastname: Shio
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Shioya
authors.forename: Etsuko
authors.initials: E
authors.lastname: Fukaya
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saito
authors.forename: Hideharu
authors.initials: H
authors.lastname: Sekine
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Orikasa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sato
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D003106:Colon / Q000187:drug effects / Q000473:pathology; D003113:Colonoscopy; D004733:Enema; D005260:Female; D006801:Humans; D019804:Mesalamine / Q000008:administration & dosage* / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine