[Effect of tea polyphenol on liver fibrosis in rats and related mechanism].
OBJECTIVE
To investigate the effect of tea polyphenol (TP)'s on liver fibrosis in rats and its possible mechanism.


METHODS
Rats were divided into 5 groups, 4 groups of which were stomach perfused with alcohol resulting in alcoholic liver fibrosis, and 3 groups of which were stomach perfused with TP simultaneously. Another group was normal control one. Histological change of rat liver was investigated and quantitative analysis was made in 24 weeks, and rat liver anti-oxidation index and serum endotoxin were determined at the same time.


RESULTS
Liver fibrosis in TP group was slight, and anti-oxidize index and endotoxin level were markedly improved in comparison with those of alcohol groups.


CONCLUSIONS
Tea polyphenol can protect hepatocytes from fibrosis. Its mechanism is possibly due to cleaning up overfull lipid per-oxidation and reducing the level of endotoxin.
Zhang
Xing-guo
XG
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China. ZXG777@sohu.com
Yu
Chao-hui
CH
Qing
Yu-e
YE
Zhang
Yu
Y
Chen
Shao-hua
SH
Li
You-ming
YM
D000818:Animals; D003094:Collagen / Q000378:metabolism; D004731:Endotoxins / Q000097:blood*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D005978:Glutathione / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood* / Q000209:etiology / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000150:complications*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D059808:Polyphenols; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D013662:Tea / Q000737:chemistry
D004731:Endotoxins; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D020011:Protective Agents; D013662:Tea; D008315:Malondialdehyde; D003094:Collagen; D013482:Superoxide Dismutase; D005978:Glutathione