title: Increased level of polymerase III transcribed Alu RNA in hepatocellular carcinoma tissue.
abstract: There have been extensive observations that RNA containing repetitive elements accumulates in transformed cells and tumor tissues. In the present study, we first obtained result consistent with previous observations by in situ hybridization. Then we used primer extension analysis to determine the level of polymerase III directed Alu RNA and found an increased expression of Alu RNA in hepatocellular carcinoma.
authors.affiliation: Department of Histology and Embryology, the Second Military Medical University, Shanghai 200433, China.
authors.forename: Rui-Bao
authors.initials: RB
authors.lastname: Tang
authors.forename: Hong-Yang
authors.initials: HY
authors.lastname: Wang
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Xiong
authors.forename: Hong-Hua
authors.initials: HH
authors.lastname: Li
authors.forename: Xiu-Hua
authors.initials: XH
authors.lastname: Qiu
authors.forename: Hou-Qi
authors.initials: HQ
authors.lastname: Liu
mesh_terms: D020087:Alu Elements; D006528:Carcinoma, Hepatocellular / Q000201:enzymology* / Q000235:genetics*; D017931:DNA Primers / Q000737:chemistry; D006801:Humans; D017403:In Situ Hybridization; D008113:Liver Neoplasms / Q000201:enzymology* / Q000235:genetics*; D008969:Molecular Sequence Data; D012313:RNA / Q000378:metabolism; D012320:RNA Polymerase III / Q000378:metabolism / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D017931:DNA Primers; D012333:RNA, Messenger; D012313:RNA; D012320:RNA Polymerase III