[Synthesis and anti-active oxygen properties of water-soluble metal porphyrins].
OBJECTIVE
To synthesize four water-soluble metal porphyrins [5, 10, 15, 20-tetra[4-(4'-pyridine-1) butyloxy phenyl] metalloporphyrins bromide, metal = Zn (I), Cu (II), Mn (III) and Co (IV)] as analogous enzyme having two anti-active oxygen functions.


METHODS
The first function, scavenging O2-, has been proved by using riboflavine-methionine photoreduction methods. The second function, scavenging H2O2, has been demonstrated by using the oxidating Vit C. The third function, scavenging HO*, has been demonstrated by using Fenton reaction. The complexes were measured by the mice liver homogenate technique of mice.


RESULTS
Four model compounds could scavenge O2- in the concentration range of 1.0 x 10(-5) - 1.0 x 10(-6) mol x L(-1), decompose H2O2 in the concentration of 1.5 x 10(-6) - 1.0 x 10(-6) mol x L(-1), scavenge HO* in the concentration of 2.0 x 10(-8) - 1.0 x 10(-8) mol x L(-1). All showed that they had obvious action of decreasing the lipid peroxidation in the concentration of 1.0 x 10(-7) mol x L(-1).


CONCLUSIONS
All above-mentioned complexes were considered to be qualified analogous enzymes of anti-active oxygen.
Feng
Qing
Q
Tongji Medicine College, Huazhong University of Science and Technology, Wuhan 430030, China. westwind@public.wh.hb.cn
Liu
Li
L
Luo
Feng
F
Sun
Di-na
DN
Li
Zao-ying
ZY
Zhang
Yue-ning
YN
D000818:Animals; D003035:Cobalt; D003300:Copper; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000378:metabolism; D017665:Hydroxyl Radical / Q000378:metabolism; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008345:Manganese; D008665:Metalloporphyrins / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015032:Zinc
D016166:Free Radical Scavengers; D008665:Metalloporphyrins; D017382:Reactive Oxygen Species; D017665:Hydroxyl Radical; D003035:Cobalt; D008345:Manganese; D008315:Malondialdehyde; D003300:Copper; D006861:Hydrogen Peroxide; D015032:Zinc