title: [The auto-addictive hypothesis of pathological eating disorders].
abstract: The pathogenic role of self-addiction. Addiction to an endogenous chemical is a new paradigm termed 'self-addiction'. It may contribute to the development of certain habits, the pathological nature of which may set-in on the basis of this "self-addictive"dimension. Pathological eating habits could be inscribed in this perspective. Two extreme situations. In well-fed populations, the ingestion of food does not represent a limiting phase in the global feeding process. Its pathological management may, however, lead to two extreme situations: the absence of ingestion (anorexia) and excessive ingestion (bulimia). In favour of the self-addictive hypothesis. Eating disorders are associated with abnormal levels of endorphins and share clinical similarities with psychoactive drug abuse. The key role of endorphins has recently been demonstrated in animals with regard to certain aspects of normal, pathological and experimental eating habits (food restriction combined with stress, locomotor hyperactivity). The factors leading to pathological eating habits. Neurobiological bases for eating disorders and their durability have recently come to light in the recent implication of abnormalities in the recompense system in the onset of addiction. The endorphin self-addictive model in fact appears the most pertinent with regard to the clinical profile of eating habits and integrates the role of stress.
authors.affiliation: Clinique des maladies mentales et de l'encéphale, Paris (75). yasminekb@free.fr
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Lienard
authors.forename: Joseph
authors.initials: J
authors.lastname: Vamecq
mesh_terms: D016739:Behavior, Addictive / Q000503:physiopathology* / Q000523:psychology; D004298:Dopamine / Q000502:physiology; D004723:Endorphins / Q000502:physiology; D001068:Feeding and Eating Disorders / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D010555:Personality Inventory; D013312:Stress, Physiological / Q000503:physiopathology
chemical_list: D004723:Endorphins; D004298:Dopamine