Epstein-Barr virus-associated gastric carcinoma in Kazakhstan.
OBJECTIVE
To investigate the incidence of Epstein-Barr virus-associated gastric cancer (EBV-GC) in Kazakhstan and to compare it with that in Russia, Western and Asian countries in order to evaluate the significance of epidemiopathologic and ethnic factors.


METHODS
In situ hybridization (ISH) of EBV-encoded small RNA-1 (EBER-1) was used to identify the presence of EBER-1 signal in 139 formalin-fixed and paraffin-embedded GC tissues from Kazakhstan.


RESULTS
EBER-1 expression was observed in the nuclei of 10% of the cases of GC (14/139), but not in the surrounding normal mucosa. The incidence of the diffuse type of EBV-GC was significantly higher in Kazakhstan (14%, 13/91) than that of the intestinal type (2%, 1/48). Furthermore, the incidence was significantly higher in males (14%, 12/89) than in females (3.7%, 2/53) from all countries. The overall incidence of EBV-GC increased from 6.7% in Asian countries to 8.7% in Russia, 10.1% in Kazakhstan and 16% in Western countries.


CONCLUSIONS
Geographical differences in the incidence of EBV-GC may reflect the epidemiologic factors and/or dietary habits independent of histological type and sex.
Alipov
Gabit
G
Division of Scientific Data Regsitry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Nakayama
Toshiyuki
T
Nakashima
Masahiro
M
Wen
Chun-Yang
CY
Niino
Daisuke
D
Kondo
Hisayoshi
H
Pruglo
Yuri
Y
Sekine
Ichiro
I
D002288:Adenocarcinoma, Mucinous / Q000208:ethnology* / Q000473:pathology; D000328:Adult; D017677:Age Distribution; D044466:Asian People / Q000706:statistics & numerical data; D018279:Carcinoma, Signet Ring Cell / Q000208:ethnology* / Q000473:pathology; D020031:Epstein-Barr Virus Infections / Q000208:ethnology* / Q000473:pathology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D007623:Kazakhstan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012367:RNA, Viral / Q000032:analysis; D017678:Sex Distribution; D013274:Stomach Neoplasms / Q000208:ethnology* / Q000473:pathology; D044465:White People / Q000706:statistics & numerical data
D012367:RNA, Viral