Update on genome completion and annotations: Protein Information Resource.
The Protein Information Resource (PIR) recently joined the European Bioinformatics Institute (EBI) and Swiss Institute of Bioinformatics (SIB) to establish UniProt--the Universal Protein Resource--which now unifies the PIR, Swiss-Prot and TrEMBL databases. The PIRSF (SuperFamily) classification system is central to the PIR/UniProt functional annotation of proteins, providing classifications of whole proteins into a network structure to reflect their evolutionary relationships. Data integration and associative studies of protein family, function and structure are supported by the iProClass database, which offers value-added descriptions of all UniProt proteins with highly informative links to more than 50 other databases. The PIR system allows consistent, rich and accurate protein annotation for all investigators.
Wu
Cathy
C
Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC, USA.
Nebert
Daniel W
DW
D000818:Animals; D019295:Computational Biology; D030562:Databases, Protein; D015894:Genome, Human; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D011506:Proteins / Q000145:classification / Q000235:genetics
D011506:Proteins