title: Renal concentrating capacity is linked to blood pressure in children with autosomal dominant polycystic kidney disease.
abstract: Impaired glomerular filtration rate (GFR) is a risk factor for the development of hypertension in patients with autosomal dominant polycystic kidney disease (ADPKD). However, markers of tubular function were not tested whether they are linked to hypertension or blood pressure (BP) level. The aim of our study was to investigate the relationship between renal concentrating capacity and BP in children with ADPKD. Fifty-three children (mean age 11.8+/-4.4 years) were investigated. Standardized renal concentrating capacity test was performed after nasal drop application of desmopressin, BP was measured by ambulatory BP monitoring (ABPM). Renal concentrating capacity was decreased in 58 % of children. The prevalence of hypertension was significantly higher in children with decreased renal concentrating capacity (35 %) than in children with normal renal concentrating capacity (5 %) (p<0.05). Significant negative correlations were found between renal concentrating capacity, ambulatory BP and number of renal cysts (r = -0.29 to -0.39, p<0.05 to p<0.01). In conclusion, the concentrating capacity is decreased in about half of the patients and is linked to BP. Decreased renal concentrating capacity should be considered.
authors.affiliation: First Department of Pediatrics, University Hospital Motol, Prague, Czech Republic. tomas.seeman@lfmotol.cuni.cz
authors.forename: T
authors.initials: T
authors.lastname: Seeman
authors.forename: J
authors.initials: J
authors.lastname: Dusek
authors.forename: K
authors.initials: K
authors.lastname: Vondrák
authors.forename: K
authors.initials: K
authors.lastname: Bláhová
authors.forename: E
authors.initials: E
authors.lastname: Simková
authors.forename: J
authors.initials: J
authors.lastname: Kreisinger
authors.forename: P
authors.initials: P
authors.lastname: Dvorák
authors.forename: M
authors.initials: M
authors.lastname: Kyncl
authors.forename: Z
authors.initials: Z
authors.lastname: Hríbal
authors.forename: J
authors.initials: J
authors.lastname: Janda
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D007671:Kidney Concentrating Ability; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013223:Statistics as Topic