[Pharmacokinetics and targeting characteristics of adriamycin after canine hepatic arterial embolization with adriamycin-lipiodol emulsion].
OBJECTIVE
To study the phamacokinetics and targeting characteristics of adriamyin in dogs following embolization of hepatic artery with adriamyin-lipiodol emulsion (AD-E).


METHODS
After injection of adriamycin solution and the emulsion, respectively, into the hepatic artery via a femoral artery of the dogs, the concentration of adriamycin in the peripheral venous blood and hepatic tissue were determined by high-performance liquid chromatography.


RESULTS
The concentration of adriamycin in peripheral venous blood was significantly lowered after AD-E embolization in comparison with that after adriamycin solution injection. Adriamycin concentration in the hepatic tissue at 10, 24, and 48 h after AD-E embolization was 5.42, 3.33 and 2.38 times that of adrimycin solution group, respectively.


CONCLUSIONS
Compared to adriamycin solution, AD-E as an embolic agent can significantly alter the serum pharmacokinetics and liver targeting characteristics of adriamycin.
Wang
Xin-ya
XY
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Yang
Li
L
Cheng
Ye-hao
YH
D000818:Animals; D016461:Chemoembolization, Therapeutic; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D004655:Emulsions; D006499:Hepatic Artery; D007459:Iodized Oil / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D011897:Random Allocation
D004655:Emulsions; D007459:Iodized Oil; D004317:Doxorubicin