Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection.
In recent years, a number of newer designer drugs have entered the illicit drug market. The methylenedioxy-derivates of amphetamine represent the largest group of designer drugs. This paper describes a method for screening for and quantification of ten 2,5-methylenedioxy-derivates of amphetamine and phenylethylamine in human urine, using capillary electrophoresis coupled to electrospray ionisation-mass spectrometry (CE-ESI-MS). Prior to CE-MS analysis, a simple solid-phase extraction (SPE) was used for sample cleanup. The method was validates according to international guidelines.
Boatto
Gianpiero
G
Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Italy. gboatto@uniss.it
Nieddu
Maria
M
Carta
Antonio
A
Pau
Amedeo
A
Palomba
Michele
M
Asproni
Battistina
B
Cerri
Riccardo
R
D000662:Amphetamines / Q000652:urine*; D015198:Designer Drugs / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D000662:Amphetamines; D015198:Designer Drugs