title: Oral alveolar soft-part sarcoma: review of literature and case report with immunohistochemistry study for prognostic markers.
abstract: OBJECTIVE
  To describe a case of alveolar soft-part sarcoma (ASPS) affecting the tongue of a child and to study prognostic imunohistochemical markers for the disease.
  
  
  METHODS
  Tissue sections were incubated with primary antibodies reactive to neuron-specific enolase (NSE), vimentin, desmin, S-100 protein, cytokeratins AE1-AE3, EMA, neurofilament, synaptophysin, and muscle-specific actin (MSA), and for prognostic markers, including Ki-67, p53, bcl-2, bax, and nm23.
  
  
  RESULTS
  Histologically, the tumor showed a proliferation of large polygonal cells with PAS-positive diastase-resistant intracytoplasmatic material, arranged in an alveolar growth pattern. Diffuse positive reaction for neuron specific enolase (NSE), focal reactivity for desmin and S-100 protein, strong positivity for nm23 and bax, but weak reaction for p53 and Ki-67 were found. No bcl-2-positive cells were noted.
  
  
  CONCLUSIONS
  These immunohistochemical findings may reflect the less aggressive behavior of ASPS in oral tissues.
authors.affiliation: Department of General Pathology, School of Medicine, FMTM Uberaba, Brazil.
authors.forename: Kelen Christine
authors.initials: KC
authors.lastname: do Nascimento Souza
authors.forename: Paulo Rogério
authors.initials: PR
authors.lastname: Faria
authors.forename: Ivan Miguel
authors.initials: IM
authors.lastname: Costa
authors.forename: Antonio Francisco
authors.initials: AF
authors.lastname: Duriguetto
authors.forename: Adriano Mota
authors.initials: AM
authors.lastname: Loyola
mesh_terms: D000199:Actins / Q000032:analysis; D000293:Adolescent; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D003893:Desmin / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D018396:Mucin-1 / Q000032:analysis; D054778:NM23 Nucleoside Diphosphate Kinases; D016900:Neurofilament Proteins / Q000032:analysis; D009701:Nucleoside-Diphosphate Kinase / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D018234:Sarcoma, Alveolar Soft Part / Q000473:pathology*; D016708:Synaptophysin / Q000032:analysis; D014062:Tongue Neoplasms / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D051028:bcl-2-Associated X Protein
chemical_list: D000199:Actins; D000951:Antigens, Neoplasm; C494826:BAX protein, human; D014408:Biomarkers, Tumor; D003893:Desmin; D019394:Ki-67 Antigen; D018396:Mucin-1; D054778:NM23 Nucleoside Diphosphate Kinases; D016900:Neurofilament Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D009418:S100 Proteins; D016708:Synaptophysin; D016159:Tumor Suppressor Protein p53; D014746:Vimentin; D051028:bcl-2-Associated X Protein; D007633:Keratins; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D010751:Phosphopyruvate Hydratase