title: Is plasminogen activator inhibitor-1 a cardiovascular risk factor in young women with polycystic ovary syndrome?
abstract: This study aimed to evaluate plasminogen activator inhibitor-1 (PAI-1) activity in PCOS. Thirty women with PCOS - 15 normal-weight and 15 obese - and 30 healthy women matched as a group for age and body mass index (BMI) were recruited. The homeostasis model assessment (HOMA) score was significantly elevated in obese compared with normal-weight women, in both PCOS women and controls. HOMA score was significantly higher in both PCOS groups relative to controls. After further adjustment for BMI, PAI-1 activity (IU/ml +/- SD) was significantly higher in the PCOS groups compared with controls. A significant positive correlation was found between HOMA score and BMI in PCOS and control groups. Serum PAI-1 activity was significantly related to BMI and HOMA score. When considering two BMI subgroups, there was no significant difference in the relationship between serum PAI-1 activity and HOMA score in both the control and PCOS groups. No other significant relationship was found between serum PAI-1 activity and any other hormonal or metabolic parameter. In conclusion, women with PCOS have significantly elevated PAI-1 activity independent of obesity, and it is speculated that elevated PAI-1 activity may be a factor in the increased cardiovascular morbidity seen in PCOS.
authors.affiliation: Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy. francescoorio@virgilio.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Orio
authors.forename: Stefano
authors.initials: S
authors.lastname: Palomba
authors.forename: Teresa
authors.initials: T
authors.lastname: Cascella
authors.forename: Libuse
authors.initials: L
authors.lastname: Tauchmanovà
authors.forename: Luciano G
authors.initials: LG
authors.lastname: Nardo
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Di Biase
authors.forename: Donato
authors.initials: D
authors.lastname: Labella
authors.forename: Tiziana
authors.initials: T
authors.lastname: Russo
authors.forename: Silvia
authors.initials: S
authors.lastname: Savastano
authors.forename: Achille
authors.initials: A
authors.lastname: Tolino
authors.forename: Fulvio
authors.initials: F
authors.lastname: Zullo
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.forename: Gaetano
authors.initials: G
authors.lastname: Lombardi
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000097:blood* / Q000401:mortality*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood / Q000401:mortality; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000401:mortality*; D012307:Risk Factors
chemical_list: D017395:Plasminogen Activator Inhibitor 1