title: Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
abstract: Asthma affects nearly 14 million people worldwide and has been steadily increasing in frequency for the past 50 years. Although environmental factors clearly influence the onset, progression, and severity of this disease, family and twin studies indicate that genetic variation also influences susceptibility. Linkage of asthma and related phenotypes to chromosome 6p21 has been reported in seven genome screens, making it the most replicated region of the genome. However, because many genes with individually small effects are likely to contribute to risk, identification of asthma susceptibility loci has been challenging. In this study, we present evidence from four independent samples in support of HLA-G as a novel asthma and bronchial hyperresponsiveness susceptibility gene in the human leukocyte antigen region on chromosome 6p21, and we speculate that this gene might contribute to risk for other inflammatory diseases that show linkage to this region.
authors.affiliation: Department of Statistics, The University of Chicago, Chicago, IL, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Nicolae
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Cox
authors.forename: Lucille A
authors.initials: LA
authors.lastname: Lester
authors.forename: Daniel
authors.initials: D
authors.lastname: Schneider
authors.forename: Zheng
authors.initials: Z
authors.lastname: Tan
authors.forename: Christine
authors.initials: C
authors.lastname: Billstrand
authors.forename: Susan
authors.initials: S
authors.lastname: Kuldanek
authors.forename: Joseph
authors.initials: J
authors.lastname: Donfack
authors.forename: Paul
authors.initials: P
authors.lastname: Kogut
authors.forename: Nina M
authors.initials: NM
authors.lastname: Patel
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Goodenbour
authors.forename: Timothy
authors.initials: T
authors.lastname: Howard
authors.forename: Raoul
authors.initials: R
authors.lastname: Wolf
authors.forename: Gerard H
authors.initials: GH
authors.lastname: Koppelman
authors.forename: Steven R
authors.initials: SR
authors.lastname: White
authors.forename: Rodney
authors.initials: R
authors.lastname: Parry
authors.forename: Dirkje S
authors.initials: DS
authors.lastname: Postma
authors.forename: Deborah
authors.initials: D
authors.lastname: Meyers
authors.forename: Eugene R
authors.initials: ER
authors.lastname: Bleecker
authors.forename: Joan S
authors.initials: JS
authors.lastname: Hunt
authors.forename: Julian
authors.initials: J
authors.lastname: Solway
authors.forename: Carole
authors.initials: C
authors.lastname: Ober
mesh_terms: D000328:Adult; D001249:Asthma / Q000235:genetics*; D016535:Bronchial Hyperreactivity / Q000235:genetics; D002648:Child; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D010641:Phenotype
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I