Comparative studies of vasodilating effects of angiotensin-(1-7) on the different vessels.
The purpose of this study was to compare the vasodilating effects of angiotensin-(1-7) [Ang-(1-7)] on the different vessels and to clarify its mechanisms by using relaxing responses of preconstricted vascular rings. The results showed: (1) Ang-(1-7) dose-dependently induced vasorelaxation in all the vessels studied. However, there is apparent heterogeneity in the responsiveness of vessels from different origin. (2) The Ang-(1-7)-induced vasorelaxation was endothelium dependent and largely mediated by NO system. (3) The vasodilator action of Ang-(1-7) was not mediated by AT1 or AT2 receptor subtypes. It is suggested that the Ang-(1-7)-induced vasorelaxation is endothelium dependent by some other unclarified angiotensin receptor subtypes and is largely mediated by NO system.
Zhi
Jian-Ming
JM
Department of Physiology, Shanghai Second Medical University, Shanghai 200025, China. zhjm169@sohu.com
Chen
Rong-Fang
RF
Wang
Jin
J
Jiao
Xiang-Ying
XY
Zhao
Rong-Rui
RR
D000803:Angiotensin I / Q000494:pharmacology* / Q000502:physiology; D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis*; D010446:Peptide Fragments / Q000494:pharmacology*; D011817:Rabbits; D044140:Receptor, Angiotensin, Type 1 / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology*
D010446:Peptide Fragments; D044140:Receptor, Angiotensin, Type 1; D014665:Vasodilator Agents; D009569:Nitric Oxide; D000803:Angiotensin I; C118790:angiotensin I (1-7)