title: Total hemolytic complement values in normal and diseased dog populations.
abstract: The optimum conditions for handling and storage of canine sera for total hemolytic complement assays were assessed. Sera from 113 normal dogs and 217 clinical admissions to the University of Pennsylvania Veterinary Hospital were assayed for total hemolytic complement levels. Normal sera had a mean value of 185 CH50 units. Sera from animals with systemic lupus erythematosus and hemorrhagic gastroenteritis, had significantly lower mean levels of complement than the normal group. Sera from dogs with generalized demodectic mange, tumors, various inflammatory diseases, hypothyroidism, seborrhea, and rheumatoid arthritis had values significantly higher than the normal population.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Wolfe
authors.forename: R E
authors.initials: RE
authors.lastname: Halliwell
mesh_terms: D000818:Animals; D003165:Complement System Proteins / Q000032:analysis*; D004283:Dog Diseases / Q000097:blood / Q000276:immunology*; D004285:Dogs; D005260:Female; D008297:Male; D012016:Reference Values; D013048:Specimen Handling / Q000379:methods / Q000662:veterinary
chemical_list: D003165:Complement System Proteins