[Effect of insulin on expression of whole-blood platelet membrane P-selectin].
OBJECTIVE
To investigate the effects of insulin on the expression of whole-blood platelet membrane P-selectin.


METHODS
Flow cytometry (FCM) was used to detect the expression of whole-blood platelet membrane P-selectin, and the effect of insulin on the expression on quiescent and activated plasma platelet observed in normal young subjects.


RESULTS
Insulin had no effect on the P-selectin expression on quiescent platelet membrane, but significantly inhibited the up-regulation of P-selectin expression induced by thrombin and collagen respectively, exhibiting dose- and time-dependent effects.


CONCLUSIONS
Insulin can inhibit P-selectin expression on activated platelet membrane.
Peng
Bi-you
BY
Clinic of Dongkeng Labor Reeducation Camp, Justice Bureau of Guangzhou, Guangzhou 510515, China. pengbiyou@fm365.com
Zhou
Yan
Y
Dong
Wei-ren
WR
Wang
Ji-yi
JY
Xue
Yao-ming
YM
Cai
De-hong
DH
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D019007:P-Selectin / Q000096:biosynthesis* / Q000235:genetics; D015539:Platelet Activation
D007328:Insulin; D019007:P-Selectin