title: [Colestasic toxic hepatitis caused by terbinafine: case report].
abstract: Trichophytic onychomycosis of the feet represents an important and serious medical problem. Until recent years, there was not cure for this unpleasant pathology. It is only at the beginning of the 50s, especially at the onset of the antimycotic systemic therapy that a cure is available offering high rate of clinical and mycological therapy. The purpose of this report is to better inform on the undesirable side-effects of antimycotic agents which are currently so largely disseminated. The case of a young patient is presented who was enjoying good health and who after 6 weeks of starting therapy with terbinafine on a doses of 1 pill of 250 mg a day, to treat a trichophytic onychomycosis in both feet, developed severe symptoms of toxic colostatic hepatitis duly corroborated after pertinent testing. Patient had a full recovery after a few months of having interrupted her therapy, apparently without any sequel. The literature in this regard has been revised and a close monitoring of the hepatic function is recommended prior and during treatment with this drug. The need to continue research to find an ideal antimycotic still not found is also recommended.
authors.affiliation: Servicio de Dermatología Sanitaria, Instituto de Medicina Tropical Daniel A. Carrión, UNMSM.
authors.forename: Zuño
authors.initials: Z
authors.lastname: Burstein
authors.forename: Herman
authors.initials: H
authors.lastname: Vildósola
authors.forename: Zenaida
authors.initials: Z
authors.lastname: Lozano
authors.forename: Roger
authors.initials: R
authors.lastname: Verona
authors.forename: Gloria
authors.initials: G
authors.lastname: Vargas
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D002779:Cholestasis / Q000139:chemically induced* / Q000628:therapy; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D009281:Naphthalenes / Q000009:adverse effects*; D000077291:Terbinafine; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine