Antioxidant activities of extracts from five anti-viral medicinal plants.
The antioxidant activities of five medicinal plants (Ampelopsis sinica, Ampelopsis humiliforlia var. heterophylla, Potentilla freyniana, Selaginella labordei and Chrysanthemum multiflorum), used in the Hubei province of China, have been investigated using both enzymatic and non-enzymatic in vitro antioxidant assays. Extracts from all five of the plants inhibited xanthine oxidase and lipoxygenase activities, and were scavengers of the ABTS*+ radical cation using the Trolox equivalent antioxidant capacity assay (TEAC). Extracts from Potentilla freyniana and Selaginella labordei down-regulated cyclooxygenase-2 gene expression, measured by real-time RT-PCR, in human colon adenocarcinoma CaCo-2 cells.
Chen
Keli
K
Nutrition Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK.
Plumb
Geoff W
GW
Bennett
Richard N
RN
Bao
Yongping
Y
D032421:Ampelopsis; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D018938:Caco-2 Cells; D031202:Chrysanthemum; D051546:Cyclooxygenase 2; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D008565:Membrane Proteins; D031987:Potentilla; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D032503:Selaginellaceae; D013997:Time Factors; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D000975:Antioxidants; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins; D012333:RNA, Messenger; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D014969:Xanthine Oxidase