[Growth hormone deficiency and age-related erectile dysfunction].
The incidence of erectile dysfunction (ED) significantly increases in aging men, which may be associated with the decrease of the serum growth hormone (GH) level. GH may play an important role in the maintenance of penile erectile function, perhaps by promotion of the NO-cGMP pathway, stimulation of the regeneration of NOS-containing nerve fibers and the augmentation of androgenic action.
Huang
Xing
X
Research Center of Urology & Andrology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Li
Shilin
S
Hu
Liquan
L
D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D006152:Cyclic GMP / Q000096:biosynthesis; D007172:Erectile Dysfunction / Q000503:physiopathology*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000096:biosynthesis; D051381:Rats; D015398:Signal Transduction / Q000502:physiology
D013006:Growth Hormone; D019001:Nitric Oxide Synthase; D006152:Cyclic GMP