Expression of LL-37, human beta defensin-2, and CCR6 mRNA in patients with psoriasis vulgaris.
To investigate whether LL-37 and human beta defensin-2 (hBD-2) is related to the patients with psoriasis seldom having skin infections and explore the role of the two peptides and CCR6 (the receptor of hBD-2) in the pathogenesis of psoriasis, the expression levels of mRNA of LL-37, hBD-2, and CCR6 in skin lesions of patients with psoriasis vulgaris were detected by using RT-PCR. The results showed that the mRNA expression levels of the two peptides and CCR6 in psoriatic lesions all increased compared with the normal skin (P<0.001). It was suggested that up-regulated expression of LL-37 and hBD-2 might be the main reason that result in the the skin of patients with psoriasis being seldom infected, and the two peptides and CCR6 might play crucial roles in the pathogenesis of psoriasis.
Li
Dongsheng
D
Department of Dermatology, the First Hospital of Wuhan, Wuhan 430022, China.
Li
Jiawen
J
Duan
Yiqun
Y
Zhou
Xiaoyong
X
D000328:Adult; D023181:Antimicrobial Cationic Peptides / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000235:genetics* / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D054399:Receptors, CCR6; D019707:Receptors, Chemokine / Q000096:biosynthesis* / Q000235:genetics; D015854:Up-Regulation; D023083:beta-Defensins / Q000096:biosynthesis* / Q000235:genetics; D054804:Cathelicidins
D023181:Antimicrobial Cationic Peptides; C106311:CCR6 protein, human; C106641:DEFB4A protein, human; D012333:RNA, Messenger; D054399:Receptors, CCR6; D019707:Receptors, Chemokine; D023083:beta-Defensins; D054804:Cathelicidins