A major genotype in UDP-glucuronosyltransferase 2B15.
A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations. The SNP was as follows: SNP, 020228Toide001; GENE NAME, UGT2B15; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5'-AGCTTGCCAAAAC/AAGGAAAGAAGAA-3'. This SNP was expected to cause a change of an amino acid residue at the position 523 (Thr to Lys) located in a putative co-factor binding region. The allele frequency of this SNP was 79% in Japanese, suggesting this polymorphism to be a major genotype in Japanese people.
Toide
Kenji
K
Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Umeda
Shin-Ichiro
S
Yamazaki
Hiroshi
H
Takahashi
Yoshiki
Y
Terauchi
Yoshiaki
Y
Fujii
Toshihiko
T
Kamataki
Tetsuya
T