title: New polyhydroxylated sterols stylisterols A-C and a novel 5,19-cyclosterol hatomasterol from the Okinawan marine sponge Stylissa sp.
abstract: New polyhydroxylated sterols, stylisterol A-C (1-3), and a novel 5,19-cyclosterol, hatomasterol (4) were isolated from the Okinawan sponge Stylissa sp. Structural determinations of these compounds were made by spectroscopic analysis and chemical conversion. Assessment of cytotoxicity toward HeLa cells was also determined.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Hidemichi
authors.initials: H
authors.lastname: Mitome
authors.forename: Nao
authors.initials: N
authors.lastname: Shirato
authors.forename: Ayako
authors.initials: A
authors.lastname: Hoshino
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyaoka
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Yamada
authors.forename: Rob W M
authors.initials: RW
authors.lastname: Van Soest
mesh_terms: D000818:Animals; D006367:HeLa Cells; D006801:Humans; D006900:Hydroxylation; D008958:Models, Molecular; D011161:Porifera / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D013261:Sterols