title: Remembering the past: neuroimaging studies of human memory.
abstract: The ability to find our way around an environment and to remember the events that occur within it are fundamental to normal functioning in daily life. Impairment of these abilities are among the first symptoms to be reported in patients with pathologies such as Alzheimer's disease and anoxia that are linked to the hippocampus and other limbic structures. However, many questions remain unanswered regarding the nature and neural bases of these memories. Findings from functional neuroimaging studies offer insights into the anatomy of memory and the presentation of memory impairments. In particular, neuroimaging is well placed to inform about the functionality of residual brain tissue, and the plasticity of memory anatomy in the context of hippocampal damage, and normal ageing.
authors.affiliation: Department of Imaging Neuroscience, Institute of Neurology, University College London, UK.
authors.forename: E A
authors.initials: EA
authors.lastname: Maguire
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008568:Memory / Q000502:physiology*