[Study on polymorphisms in metabolic enzyme genes, DNA repair genes and individual susceptibility to childhood leukemia].
Leukemia is the most common malignancy in children. The inter-individual variation in the capacity of xenobiotic metabolizing and DNA repair was shown to modify somatic mutation burden in the context of environmental exposure and determine genetic susceptibility to malignancies. In this paper, studies on polymorphisms of metabolic enzymes and DNA repair and, susceptibility to childhood leukemia are reviewed.
Zhu
Ren
R
School of Public Health, Fudan University, Shanghai 200032, China.
Xia
Zhaolin
Z
D002648:Child; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics; D009195:Peroxidase / Q000235:genetics; D011110:Polymorphism, Genetic
D003577:Cytochrome P-450 Enzyme System; D009195:Peroxidase; D016660:NAD(P)H Dehydrogenase (Quinone); D005982:Glutathione Transferase