Anti-diabetic activities of fucosterol from Pelvetia siliquosa.
Fucosterol isolated from Pelvetia siliquosa was tested for its anti-diabetic activity in vivo. Fucosterol, when administered orally at 30 mg/kg in streptozotocin-induced diabetic rats, was caused a significant decrease in serum glucose concentrations, and exhibited an inhibition of sorbitol accumulations in the lenses. Fucosterol, when administered orally at 300 mg/kg in epinephrine-induced diabetic rats, was also caused an inhibition of blood glucose level and glycogen degradation. These results demonstrated that fucosterol is a main anti-diabetic principle from the marine algae P. siliquosa.
Lee
Yeon Sil
YS
Seokwon Life Science Research Institute, World Sea Green Co Ltd, Paju 413-832, Korea.
Shin
Kuk Hyun
KH
Kim
Bak-Kwang
BK
Lee
Sanghyun
S
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051379:Mice; D000459:Phaeophyceae / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012236:Rhodanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013265:Stigmasterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053778:Thiazolidines
D001786:Blood Glucose; D008112:Liver Glycogen; D053778:Thiazolidines; C038131:epalrestat; C015896:fucosterol; D012236:Rhodanine; D013265:Stigmasterol