[Effect of hot and humid environment on bone marrow and spleen of mice exposed to gamma irradiation].
OBJECTIVE
To study the effect of hot and humid environment (HHE) on the bone marrow and spleen in mouse exposed to gamma irradiation.


METHODS
After exposure to gamma irradiation at the dosage of 6.5 Gy, the mice were subjected to treatment in HHE for 1 h or at room temperature (RT) respectively. After exposure to HHE, the mice in HHE group were kept at RT. The bone marrow and spleen of the mice in both RT and HHE groups were examined at 1, 3, 5, 9 and 15 days after irradiation for bone marrow cellularity, DNA content in the bone marrow cells, and spleen/body weight ratio.


RESULTS
Compared with the RT group, mice in the HEE group showed aggravation of decreases in bone marrow cells, DNA content and spleen/body weight ratio.


CONCLUSIONS
HHE aggravates radiation injury of the bone marrow and spleen in mice.
Zheng
Li
L
Department of Radiation Medicine, Southern Medical University, Guangzhou 510515, China. fyzhengli@21cn.com
Zhou
Mei-juan
MJ
Ding
Zhen-hua
ZH
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D002980:Climate; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006358:Hot Temperature; D006813:Humidity; D008297:Male; D051379:Mice; D013154:Spleen / Q000528:radiation effects*; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes