Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease.
We analyzed the concentrations of four chemokines in the cerebrospinal fluid (CSF) and sera in Vogt-Koyanagi-Harada disease (VKH), an autoimmune uveomeningitis syndrome against melanocyte-associated proteins, with ELISA. CSF-CXCL10/IP-10 and CSF-CCL17/TARC were significantly elevated in VKH than in controls. In the majority of VKH cases and controls, CSF-CXCL10 was higher than serum-CXCL10, and CSF-CCL17 was lower than serum-CCL17. CCL11/Eotaxin was not different between groups. CSF-CCL2/MCP-1 was significantly lower in VKH than in control. The changes in VKH were essentially similar to those in multiple sclerosis, a known Th1-dominant condition.
Miyazawa
Isabelle
I
Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai 980-8574, Japan.
Abe
Toshiaki
T
Narikawa
Koichi
K
Feng
Juan
J
Misu
Tatsuro
T
Nakashima
Ichiro
I
Fujimori
Juichi
J
Tamai
Makoto
M
Fujihara
Kazuo
K
Itoyama
Yasuto
Y
D000293:Adolescent; D000328:Adult; D018925:Chemokines / Q000097:blood* / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D014607:Uveomeningoencephalitic Syndrome / Q000097:blood* / Q000134:cerebrospinal fluid*
D018925:Chemokines