Simplified PET measurement for evaluating histamine H1 receptors in human brains using [11C]doxepin.
The aim of this study was to develop simplified positron emission tomography measurement using [(11)C]doxepin ([(11)C]DOX) to evaluate histamine H(1) receptors (H1Rs) in human brains. We evaluated the correlation between the distribution volume (DV) of [(11)C]DOX, estimated quantitatively with a two-compartment model, and the [(11)C]DOX uptake obtained at various time intervals and normalized using the metabolite-corrected plasma radioactivity. We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [(11)C]DOX-H1R binding.
Mochizuki
Hideki
H
Department of Pharmacology, Tohoku University School of Medicine, Sendai 980-8575, Japan.
Kimura
Yuichi
Y
Ishii
Kenji
K
Oda
Keiichi
K
Sasaki
Toru
T
Tashiro
Manabu
M
Yanai
Kazuhiko
K
Ishiwata
Kiichi
K
D000328:Adult; D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002250:Carbon Radioisotopes; D004316:Doxepin / Q000493:pharmacokinetics*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D013223:Statistics as Topic; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D011969:Receptors, Histamine H1; D004316:Doxepin