title: Multi-scale modelling and the IUPS physiome project.
abstract: We review the development of models of cellular and tissue function and in particular address issues of multi-scale modelling, including the transition from stochastic models to continuum models and the incorporation of cell and tissue structure. The heart is used as an example of linking models at the molecular level to cell, tissue and organ level function.
authors.affiliation: Bioengineering Institute, The University of Auckland, Private Bag 92019 Auckland, New Zealand.
authors.forename: Edmund J
authors.initials: EJ
authors.lastname: Crampin
authors.forename: Nicolas P
authors.initials: NP
authors.lastname: Smith
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hunter
mesh_terms: D000818:Animals; D001669:Biochemical Phenomena; D001671:Biochemistry; D002468:Cell Physiological Phenomena; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology; D008954:Models, Biological; D008962:Models, Theoretical; D013269:Stochastic Processes