Protective constituents against sepsis in mice from the root cortex of Paeonia suffruticosa.
The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoniflorin (5), oxypaeoniflorin (6), apiopaeonoside (7), and methyl 3-hydroxy-4-methoxybenzoate (8). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 17% for the control experiment) and reduced alanine aminotransferase level to be a half of the control value on the sepsis model induced by lipopolysaccharide/D-galactosamine.
Li
Gao
G
College of Pharmacy, Yanbian University, Yanji 133000, P R China.
Seo
Chang-Seob
CS
Lee
Kyeung-Seon
KS
Kim
Hyo-Jin
HJ
Chang
Hyun-Wook
HW
Jung
Jun-Sub
JS
Song
Dong-Keun
DK
Son
Jong-Keun
JK
D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D029596:Paeonia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D018805:Sepsis / Q000097:blood / Q000401:mortality / Q000517:prevention & control*; D015996:Survival Rate; D013997:Time Factors
D010936:Plant Extracts; D000410:Alanine Transaminase