Intestinal immunity following a single intraperitoneal immunisation in lambs.
A single intraperitoneal injection of ovalbumin in oil adjuvant in young lambs has been shown to result in the appearance in the intestinal lamina propria of antibody-containing cells, most of which contained antibody of IgA specificity. Intraperitoneal immunisation of lambs with a Salmonella typhimurium vaccine during the suckling period provided protection against postweaning challenge with live organisms. This response was shown to be associated with specific IgA antibody in intestinal secretion.
Husband
A J
AJ
New South Wales Department of Agriculture, Veterinary Research Station, Glenfield. NSW 2167, Australia.
D000818:Animals; D000833:Animals, Suckling; D000907:Antibodies, Bacterial / Q000097:blood; D005260:Female; D007114:Immunization / Q000662:veterinary*; D007070:Immunoglobulin A / Q000097:blood; D010047:Ovalbumin / Q000276:immunology; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D022562:Salmonella Vaccines / Q000276:immunology / Q000592:standards / Q000627:therapeutic use*; D012486:Salmonella typhimurium / Q000276:immunology*; D012756:Sheep / Q000276:immunology*; D012757:Sheep Diseases / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control*
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D022562:Salmonella Vaccines; D010047:Ovalbumin