[Effects of myostatin and other growth factors on cultured human cells].
A dedicated cell-based biological test system was used for studying specific effects of myostatin and other human growth factors on the proliferation of cultured myoblasts and fibroblasts. Myostatin inhibited myoblast growth without affecting human fibroblasts. In this test system, human growth hormone and insulin-like growth factor I acted as antagonists of myostatin, which indicates that these agents have a potential for blocking its effects in vivo.
Shishkin
S S
SS
Krokhina
T B
TB
Akhunov
V S
VS
Makarov
A A
AA
Popov
V O
VO
D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D055435:Myostatin; D016212:Transforming Growth Factor beta / Q000502:physiology*
D006133:Growth Substances; C525911:MSTN protein, human; D055435:Myostatin; D016212:Transforming Growth Factor beta