Participation of endogenous corticosteroids in inflammatory response in type 2 streptozotocin diabetic rats.
The inflammatory response is decreased in diabetic animals. After adrenals removal this impaired response in type 2 diabetic rats evaluated by pleurisy and vascular permeability tests was restored. Our studies demonstrate that endogenous corticosteroids play a partial role in the impaired inflammatory response in type 2 streptozotocin diabetic rats.
de Melo
G A N
GA
Paranaense University, 87502-210 Umuarama, PR, Brazil.
Sartoretto
J L
JL
Caparroz-Assef
S M
SM
Bersani-Amado
C A
CA
Fortes
Z B
ZB
Cuman
R K N
RK
D000305:Adrenal Cortex Hormones / Q000502:physiology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000473:pathology*; D018836:Inflammation Mediators / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000305:Adrenal Cortex Hormones; D018836:Inflammation Mediators