Relationship between copper, glycopeptide, and macrolide resistance among Enterococcus faecium strains isolated from pigs in Denmark between 1997 and 2003.
A significant relationship between copper resistance (tcrB), glycopeptide resistance (Tn1546), and macrolide resistance [erm(B)] in Enterococcus faecium isolated from pigs was found. The tcrB gene was located closely upstream of the Tn1546 element. However, the continued use of copper sulfate has not been able to maintain high levels of macrolide and glycopeptide resistance.
Hasman
Henrik
H
Danish Institute for Food and Veterinary Research, Bülowsvej 27, DK-1790 Copenhagen V, Denmark. hha@dfvf.dk
Aarestrup
Frank M
FM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D019327:Copper Sulfate / Q000494:pharmacology*; D004251:DNA Transposable Elements / Q000235:genetics; D003718:Denmark; D024881:Drug Resistance, Bacterial; D016984:Enterococcus faecium / Q000187:drug effects* / Q000302:isolation & purification; D006020:Glycopeptides; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013552:Swine / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D006020:Glycopeptides; D018942:Macrolides; C461665:TcrB protein, Enterococcus faecium; D019327:Copper Sulfate