title: Effective follow-up for recurrence or a second primary cancer in patients with early gastric cancer.
abstract: BACKGROUND
  Patients with early gastric cancer have an excellent prognosis with low rates of recurrence, but may have an increased risk of developing a second primary cancer. Because the number of early gastric cancers has increased, clarification of both recurrences and second primary cancers is important for the development of effective postoperative follow-up programmes.
  
  
  METHODS
  Data on 1070 patients with early gastric cancer were analysed retrospectively with respect to the clinicopathological features of both recurrence and second primary cancers after surgical treatment.
  
  
  RESULTS
  Multivariate analysis showed that lymph node metastasis and older age were independent risk factors for recurrence of early gastric cancer. The incidence of second primary cancers was 5.0 per cent; lung and colorectal cancers were detected most frequently, followed by cancers in the oesophagus, breast and remnant stomach.
  
  
  CONCLUSIONS
  Clinicopathological features of patients with early gastric cancer can be used to identify those most at risk of developing either recurrence or a second primary cancer.
authors.affiliation: Department of Surgery and Clinical Research Institute, Kyushu University, Fukuoka, Japan. yoikeda@qmed.hosp.go.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
authors.forename: M
authors.initials: M
authors.lastname: Saku
authors.forename: F
authors.initials: F
authors.lastname: Kishihara
authors.forename: Y
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D000367:Age Factors; D000368:Aged; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis*