title: The peripheral blood Valpha24+ NKT cell numbers decrease in patients with haematopoietic malignancy.
abstract: Valpha24TCR+ CD161+ NKT (Valpha24+ NKT) cells are activated by alpha-galactosylceramide and can exert anti-tumor activity against a variety of tumor cells. In this study, we assessed the Valpha24+ NKT cell numbers in peripheral blood (PB) from 30 healthy donors and 70 patients with haematopoietic malignancy including chronic myelogenous leukemia (CML), malignant lymphoma (ML), acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). Here, we demonstrated that PB Valpha24+ NKT cell numbers were significantly decreased in all the patients with haematopoietic malignancy in comparison with that in healthy donors (P < 0.005). In particular CD4- CD8- Valpha24+ NKT cell numbers were more significantly decreased in the patients with haematopoietic malignancy (P < 0.0001).
authors.affiliation: The Second Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara 634-8522, Japan. yoneda@bk9.so-net.ne.jp
authors.forename: Ken-ichirou
authors.initials: K
authors.lastname: Yoneda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Morii
authors.forename: Mie
authors.initials: M
authors.lastname: Nieda
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Tsukaguchi
authors.forename: Itsuto
authors.initials: I
authors.lastname: Amano
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Hideo
authors.initials: H
authors.lastname: Yagi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Narita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
mesh_terms: D015704:CD4 Antigens / Q000096:biosynthesis; D016827:CD8 Antigens / Q000096:biosynthesis; D005434:Flow Cytometry; D019337:Hematologic Neoplasms / Q000097:blood*; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis*; D016019:Survival Analysis
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta