The structure of mammalian fatty acid synthase turned back to front.
On page 1667 of this issue, Stuart Smith and colleagues [1] demonstrate that the animal fatty acid synthase is a head-to-head dimer rather than the head-to-tail dimer depicted in textbooks. This has important ramifications for the mechanisms of other multifunctional enzymes such as polyketide synthases [2].
Cronan
John E
JE
Department of Microbiology, University of Illinois, Urbana, 81801, USA.
D000818:Animals; D019281:Dimerization; D064429:Fatty Acid Synthases / Q000737:chemistry*; D008958:Models, Molecular; D017434:Protein Structure, Tertiary / Q000502:physiology; D051381:Rats; D017384:Sequence Deletion
D064429:Fatty Acid Synthases