title: Natural-cycle in vitro fertilization combined with in vitro maturation of immature oocytes is a potential approach in infertility treatment.
abstract: OBJECTIVE
  To describe pregnancies and live births that resulted from IVF of mature oocytes retrieved from dominant follicles in a natural cycle combined with in vitro maturation (IVM) of immature oocytes retrieved from small follicles.
  
  
  METHODS
  Case reports.
  
  
  METHODS
  McGill Reproductive Center, Royal Victoria Hospital, McGill University.
  
  
  METHODS
  Three women with normal ovaries or polycystic ovaries who underwent infertility treatment.
  
  
  METHODS
  Administration of s.c. hCG (10,000 IU) 36 hours before oocyte retrieval in a natural cycle. After aspiration of all follicles, mature oocytes were inseminated immediately; immature oocytes were matured in vitro, inseminated by intracytoplasmic sperm injection (ICSI), and then the embryos transferred.
  
  
  METHODS
  Pregnancy and live birth.
  
  
  RESULTS
  Three pregnancies (two live births and one ongoing at time of writing) were achieved after the combination of natural-cycle IVF with IVM after transfer of the resulting embryos.
  
  
  CONCLUSIONS
  Natural-cycle IVF combined with IVM might be a new approach to IVF treatment for women with various causes of infertility.
authors.affiliation: Department of Obstetrics and Gynecology, McGill Reproductive Center, Royal Victoria Hospital, Montreal, Quebec, Canada. ri-cheng.chian@muhc.mcgill.ca
authors.forename: Ri-Cheng
authors.initials: RC
authors.lastname: Chian
authors.forename: William M
authors.initials: WM
authors.lastname: Buckett
authors.forename: Ahmad Kamal
authors.initials: AK
authors.lastname: Abdul Jalil
authors.forename: Weon-Young
authors.initials: WY
authors.lastname: Son
authors.forename: Camille
authors.initials: C
authors.lastname: Sylvestre
authors.forename: Durga
authors.initials: D
authors.lastname: Rao
authors.forename: Seang Lin
authors.initials: SL
authors.lastname: Tan
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D016922:Cellular Senescence; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D007279:Injections, Subcutaneous; D008597:Menstrual Cycle; D009865:Oocytes; D006080:Ovarian Follicle; D036801:Parturition; D011085:Polycystic Ovary Syndrome / Q000150:complications; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D020858:Tissue and Organ Harvesting
chemical_list: D006063:Chorionic Gonadotropin