title: Histamine H3-receptor isoforms.
abstract: Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor. As a result a wide variety of H3-receptor isoforms are now known that display differential brain expression patterns and signalling properties. These recent discoveries are discussed in view of the growing interest of the H3 receptor as a target for the development of potential therapeutics.
authors.affiliation: Leiden/Amsterdam Center for Drug Research, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands. RA.Bakker@few.vu.nl
authors.forename: R A
authors.initials: RA
authors.lastname: Bakker
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism; D006633:Histamine Antagonists / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D008956:Models, Chemical; D008969:Molecular Sequence Data; D018377:Neurotransmitter Agents / Q000378:metabolism; D020033:Protein Isoforms; D051381:Rats; D018100:Receptors, Histamine H3 / Q000096:biosynthesis* / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D014018:Tissue Distribution
chemical_list: D006633:Histamine Antagonists; D008024:Ligands; D018377:Neurotransmitter Agents; D020033:Protein Isoforms; D018100:Receptors, Histamine H3