title: Fulminant acute disseminated encephalomyelitis mimicking acute bacterial menigoencephalitis.
abstract: Most patients with acute disseminated encephalomyelitis (ADEM) recover quickly under corticosteroid treatment and have a favourable long-term prognosis. We report on a young woman with acute onset of an extensive and solitary white-matter lesion in the left hemisphere. Fever, high pleocytosis and elevated protein in cerebrospinal fluid initially suggested bacterial meningoencephalitis. The patient died from brain herniation despite maximal conservative therapy. Histological changes in necropsy were consistent with the diagnosis ADEM. Treatment options of fulminant ADEM are discussed.
authors.affiliation: Department of Neurology and Clinical Neurophysiology, Albert-Ludwigs University, Freiburg, Germany. aharloff@nz.ukl.uni-freiburg.de
authors.forename: A
authors.initials: A
authors.lastname: Harloff
authors.forename: S
authors.initials: S
authors.lastname: Rauer
authors.forename: M
authors.initials: M
authors.lastname: Hofer
authors.forename: J
authors.initials: J
authors.lastname: Klisch
authors.forename: T
authors.initials: T
authors.lastname: Els
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis*; D005260:Female; D006801:Humans; D016920:Meningitis, Bacterial / Q000175:diagnosis*; D008590:Meningoencephalitis / Q000175:diagnosis*