title: [Treatment of hemorrhagic shock. New therapy options].
abstract: The future of shock treatment depends on the importance of scientific results, and the willingness of physicians to optimize, and to reconsider established treatment protocols. There are four major potentially promising approaches to advanced trauma life support. First, control of hemorrhage by administration of local hemostatic agents, and a better, target-controlled management of the coagulation system. Second, improving intravascular volume by recruiting blood from the venous vasculature by preventing mistakes during mechanical ventilation, and by employing alternative spontaneous (i.e. use of the inspiratory threshold valve) or artificial ventilation strategies. In addition, artificial oxygen carriers may improve intravascular volume and oxygen delivery. Third, pharmacologic support of physiologic, endogenous mechanisms involved in the compensation phase of shock, and blockade of pathomechanisms that are known to cause irreversible vasoplegia (arginine vasopressin and K(ATP) channel blockers for hemodynamic stabilization). Fourth, employing potentially protective strategies such as mild or moderate hypothermia. Finally, the ultimate vision of trauma resuscitation is the concept of "suspended animation" as a form of delayed resuscitation after protection of vital organ systems.
authors.affiliation: Universitätsklinik für Anästhesiologie und Allgemeine Intensivmedizin, Medizinische Universität Innsbruck. wolfgang.voelckel@uibk.ac.at
authors.forename: W G
authors.initials: WG
authors.lastname: Voelckel
authors.forename: A
authors.initials: A
authors.lastname: von Goedecke
authors.forename: D
authors.initials: D
authors.lastname: Fries
authors.forename: A C
authors.initials: AC
authors.lastname: Krismer
authors.forename: V
authors.initials: V
authors.lastname: Wenzel
authors.forename: K H
authors.initials: KH
authors.lastname: Lindner
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects; D001802:Blood Substitutes / Q000627:therapeutic use; D001810:Blood Volume / Q000187:drug effects / Q000502:physiology; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D007036:Hypothermia, Induced; D011379:Prognosis; D012121:Respiration, Artificial; D012771:Shock, Hemorrhagic / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*
chemical_list: D001802:Blood Substitutes; D006490:Hemostatics