title: First autopsy study of an Okinawan centenarian: absence of many age-related diseases.
abstract: Consistent with the compression-of-morbidity hypothesis, several studies have reported that a significant proportion of centenarians delay or escape age-related diseases. Of those who live with such diseases for a long time, many appear to do so with better functional status than do younger persons who do not achieve extreme old age. The authors describe the first autopsy in an Okinawan-Japanese centenarian who escaped many age-related illnesses and delayed frailty toward the end of her very long life. Her late-life morbidity pattern is contrasted with that of white centenarians.
authors.affiliation: Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Bernstein
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Willcox
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tamaki
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kunishima
authors.forename: Makoto
authors.initials: M
authors.lastname: Suzuki
authors.forename: D Craig
authors.initials: DC
authors.lastname: Willcox
authors.forename: Ji-Suk Kristen
authors.initials: JS
authors.lastname: Yoo
authors.forename: Thomas T
authors.initials: TT
authors.lastname: Perls
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001344:Autopsy; D001996:Bronchopneumonia / Q000473:pathology; D005260:Female; D006801:Humans; D007564:Japan; D008136:Longevity