title: Human leukocyte antigens B8-DRB1*03 in pediatric patients with nephropathia epidemica caused by Puumala hantavirus.
abstract: In adults, HLA haplotype B8-DRB1*03 is clearly associated with a severe clinical course of nephropathia epidemica caused by Puumala hantavirus. We investigated whether the same applies in pediatric patients. This HLA haplotype was found in 20 of 39 (51%) of the patients, a significantly higher figure than in the Finnish population (19%). There were, however, no significant differences in the clinical picture between patients with and without HLA B8-DRB1*03.
authors.affiliation: Medical School, University of Tampere,Tampere University Hospital, Tampere, Finland.
authors.forename: Jukka
authors.initials: J
authors.lastname: Mustonen
authors.forename: Niilo-Pekka
authors.initials: NP
authors.lastname: Huttunen
authors.forename: Jukka
authors.initials: J
authors.lastname: Partanen
authors.forename: Maija
authors.initials: M
authors.lastname: Baer
authors.forename: Antti
authors.initials: A
authors.lastname: Paakkala
authors.forename: Olli
authors.initials: O
authors.lastname: Vapalahti
authors.forename: Matti
authors.initials: M
authors.lastname: Uhari
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D015795:HLA-B8 Antigen / Q000235:genetics* / Q000276:immunology*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000276:immunology*; D006801:Humans; D008297:Male; D029262:Puumala virus / Q000276:immunology*
chemical_list: D015795:HLA-B8 Antigen