Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature.
BACKGROUND
Granulosa cell tumors (GCTs) of the ovary are rare, hormonally active neoplasms characterized by endocrine manifestations, an indolent course, and late relapse.


METHODS
We report a case of a prolonged history of ovarian GCT managed primarily with repeat surgical resections.


CONCLUSIONS
This case illustrates the benefits of cytoreductive surgery for the management of recurrent disease, the use of serum tumor markers to help guide therapy, and the importance of extended follow-up.
Crew
Katherine D
KD
Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA.
Cohen
Michael H
MH
Smith
Daniel H
DH
Tiersten
Amy D
AD
Feirt
Nikki M
NM
Hershman
Dawn L
DL
D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000473:pathology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery