Susceptibility for postmenopausal osteoporosis: interaction between genetic, hormonal and lifestyle factors.
Although previous studies have established the importance of genetic, hormonal and lifestyle factors separately, the integral role of these factors on bone mass in postmenopausal women is still controversial. We examined the association of the collagen 1-alpha-1 gene (COLIA1) and vitamin D receptor gene (VDR) polymorphisms, s-IGF-I, s-25OHD and lifestyle factors with bone mineral density (BMD) in postmenopausal women. We determined anthropometric parameters, lifestyle factors, serum levels of IGF-I and 25OHD, the COLIA1 Sp1 (Mscl) and VDR (Bsml, Taql) polymorphisms by PCR and BMD by dual X-ray absorptiometry in 141 ambulatory postmenopausal Spanish women. There were significant linear correlations between S-25OHD and BMD and between s-IGF-I and BMD. BMD was statistically higher in active subjects. Of the three different polymorphisms, only the COLIA1 Sp1 polymorphism was significantly associated with BMD. In the logistic regression model, the COLIA1 Sp1 polymorphism, S-25OHD, s-IGF-I and physical activity variables were independently associated with osteoporosis. Our study shows that COLIA1 Sp1 polymorphism, S-25OHD and s-IGF-I serum levels and physical activity are independently associated with BMD in postmenopausal Spanish women.
Mezquita-Raya
Pedro
P
Endocrinology Division, Hospital Torrecardenas, Almería, Spain.
Muñoz-Torres
Manuel
M
Alonso
Guillermo
G
de Luna
Juan Dios
JD
Quesada
Jose Manuel
JM
Dorado
Gabriel
G
Luque-Recio
Fernando
F
Ruiz-Requena
Maria Estrella
ME
Lopez-Rodriguez
Francisca
F
Escobar-Jiménez
Fernando
F
D000886:Anthropometry; D015519:Bone Density / Q000235:genetics*; D024042:Collagen Type I / Q000235:genetics*; D016001:Confidence Intervals; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008019:Life Style; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D013030:Spain / Q000453:epidemiology
D024042:Collagen Type I; D018167:Receptors, Calcitriol; D007334:Insulin-Like Growth Factor I