Molecular aspects of the transport and toxicity of ochratoxin a.
Ochratoxins are a class of naturally occurring compounds produced by several fungi. The most toxic is ochratoxin A (OTA), and occurrence of some human nephropathies and tumors correlate with enhanced OTA exposure. In this Account, the following areas are examined: molecular details of the binding of OTA to human serum albumin (HSA), the influences of binding to HSA on the trans-port of OTA across epithelial cell membranes by organic anion transport proteins, the oxidative activation of OTA, and the formation of OTA adducts with biological molecules. These studies are beginning to provide a detailed chemical model for the trans-port, accumulation, and genotoxic and carcinogenic effects of OTA.
Dai
Jian
J
Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27106, USA.
Park
Gyungse
G
Perry
Jennifer L
JL
Il'ichev
Yuri V
YV
Bow
Daniel A J
DA
Pritchard
John B
JB
Faucet
Virginie
V
Pfohl-Leszkowicz
Annie
A
Manderville
Richard A
RA
Simon
John D
JD
D000418:Albumins / Q000378:metabolism; D001345:Autoradiography; D001692:Biological Transport; D006801:Humans; D009793:Ochratoxins / Q000378:metabolism* / Q000633:toxicity*; D010084:Oxidation-Reduction; D011485:Protein Binding
D000418:Albumins; D009793:Ochratoxins; C025589:ochratoxin A