NK cell regulation of T cell-mediated responses.
NK cells promote adaptive immune responses through their production of type 1 and type 2 cytokines or chemokines. Secretion of these factors by activated NK cells influences the differentiation of B and T lymphocytes. Increasing evidence indicates that NK cells are also directly involved in dendritic cell (DC) maturation. By contrast, a potential role for direct cell-cell interactions between NK and T lymphocytes, in particular CD4(+) T cells, has not been explored. We provide evidence that activated human NK cells are able of promoting TcR-dependent proliferation of resting autologous peripheral blood CD4(+) T cells by a process that involves costimulatory molecules of the immunoglobulin (Ig) and tumor necrosis factor (TNF) superfamilies. These findings suggest a novel link between natural and adaptative immune responses.
Zingoni
Alessandra
A
Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, CA 94143, USA. alessandra.zingoni@uniroma1.it
Sornasse
Thierry
T
Cocks
Benjamin G
BG
Tanaka
Yuetsu
Y
Santoni
Angela
A
Lanier
Lewis L
LL
D002450:Cell Communication / Q000276:immunology*; D016207:Cytokines / Q000276:immunology / Q000502:physiology*; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D007694:Killer Cells, Natural / Q000276:immunology*; D008024:Ligands; D008213:Lymphocyte Activation / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines; D008024:Ligands