Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps.
Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here, the recently developed Multiple Genome Rearrangement (MGR) algorithm is applied to human, mouse, cat and cattle comparative maps (with 311-470 shared markers) to impute the ancestral mammalian genome. Reconstructed ancestors consist of 70-100 conserved segments shared across the genomes that have been exchanged by rearrangement events along the ordinal lineages leading to modern species genomes. Genomic distances between species, dominated by inversions (reversals) and translocations, are presented in a first multispecies attempt using ordered mapping data to reconstruct the evolutionary exchanges that preceded modern placental mammal genomes.
Murphy
William J
WJ
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA. murphywi@mail.ncifcrf.gov
Bourque
Guillaume
G
Tesler
Glenn
G
Pevzner
Pavel
P
O'Brien
Stephen J
SJ
D000465:Algorithms; D000818:Animals; D002415:Cats / Q000235:genetics; D002417:Cattle / Q000235:genetics; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D002875:Chromosomes; D002877:Chromosomes, Human; D019295:Computational Biology; D019143:Evolution, Molecular; D005260:Female; D015321:Gene Rearrangement; D005819:Genetic Markers; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008322:Mammals / Q000235:genetics*; D051379:Mice / Q000235:genetics; D015203:Reproducibility of Results; D013045:Species Specificity; D026801:Synteny; D014178:Translocation, Genetic
D005819:Genetic Markers