[The dynamics of physiological and biochemical indices of mouse status as a function of concentration of chemical toxicants in drinking water extracts].
The effect of single per os administration of oil solution of hexane-ether extracts with different contents of benzo[a]pyrene and polychlorobiphenyls on the dynamics of physiological and biochemical indices in the liver and blood of mice proved to significantly depend on chemical composition and concentration of the extract as well as time period after administration. No linear effect-dose relationships have been revealed for both physiological and biochemical indices. Administration of low doses of the extracts changed the scale and the degree of the relationship between mouse body weight and liver weight. The most pronounced changes in most biochemical indices were observed in the groups of mice administered with the lowest concentration of the extracts (5.3 x 10(-5) mg/kg).
Urnysheva
V V
VV
Smotriaeva
M A
MA
Shishkina
L N
LN
D000818:Animals; D001580:Benzopyrenes / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005618:Fresh Water; D008099:Liver / Q000473:pathology*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D001580:Benzopyrenes; D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls