title: [Effect of insulin on expression of whole-blood platelet membrane P-selectin].
abstract: OBJECTIVE
  To investigate the effects of insulin on the expression of whole-blood platelet membrane P-selectin.
  
  
  METHODS
  Flow cytometry (FCM) was used to detect the expression of whole-blood platelet membrane P-selectin, and the effect of insulin on the expression on quiescent and activated plasma platelet observed in normal young subjects.
  
  
  RESULTS
  Insulin had no effect on the P-selectin expression on quiescent platelet membrane, but significantly inhibited the up-regulation of P-selectin expression induced by thrombin and collagen respectively, exhibiting dose- and time-dependent effects.
  
  
  CONCLUSIONS
  Insulin can inhibit P-selectin expression on activated platelet membrane.
authors.affiliation: Clinic of Dongkeng Labor Reeducation Camp, Justice Bureau of Guangzhou, Guangzhou 510515, China. pengbiyou@fm365.com
authors.forename: Bi-you
authors.initials: BY
authors.lastname: Peng
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Wei-ren
authors.initials: WR
authors.lastname: Dong
authors.forename: Ji-yi
authors.initials: JY
authors.lastname: Wang
authors.forename: Yao-ming
authors.initials: YM
authors.lastname: Xue
authors.forename: De-hong
authors.initials: DH
authors.lastname: Cai
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D019007:P-Selectin / Q000096:biosynthesis* / Q000235:genetics; D015539:Platelet Activation
chemical_list: D007328:Insulin; D019007:P-Selectin