[Oxazaphosphorinane drugs. New analogues, metabolic studies, and therapeutic approaches].
Recent studies on oxazaphosphorinane drugs, with the main focus on those carried out in Poland, are briefly reviewed. Research leading to the introduction of the new antitumor drug (S)-(-)-bromofosfamide are presented. The utility of phosphorus nuclear magnetic resonance in studies of ifosfamide metabolism and an application of analogues of the final, active metabolite of this drug in gene therapy are shown.
Misiura
Konrad
K
Zakład Chemii Bioorganicznej, Centrum Badań Molekularnych i Makromolekularnych PAN, Łódź. kmisiura@bio.cbmm.lodz.pl
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D015316:Genetic Therapy; D006801:Humans; D007069:Ifosfamide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
D000970:Antineoplastic Agents; C073801:bromofosfamide; D007069:Ifosfamide