Gastroretentive delivery systems: a mini review.
Various attempts have been made to develop gastroretentive delivery systems. For example, floating, swelling, mucoadhesive, and high-density systems have been developed to increase gastric retention time of the dosage forms. It is known that differences in gastric physiology, such as, gastric pH, and motility exhibit both intra- as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behavior. Nevertheless, some floating devices have shown promising results. In this paper, the gastric physiology and the reported intragastric delivery systems have briefly been presented.
Talukder
R
R
Temple University School of Pharmacy, Philadelphia, PA 19140, USA.
Fassihi
R
R
D016503:Drug Delivery Systems / Q000379:methods*; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology; D005772:Gastrointestinal Transit / Q000187:drug effects / Q000502:physiology; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods