title: Liver metastasis 30 years after enucleation of the left eyeball for choroidal melanoma.
abstract: Here, we report a case of 70-year-old female with metastatic choroidal melanoma in the liver, which was detected 30 years after enucleation of the left eyeball. At first, two hypovascular tumors (4cm and 1cm in diameter) were detected in the liver as high-density areas on plain computed tomography (CT). They were demonstrated as hyper- and hypo-intensity lesions on T1- and T2-weighted image of magnetic resonance imaging (MRI), respectively, with superparamagnetic iron oxide uptake. During about 2-years follow-up, the larger tumor did not change significantly in size and in the character. However, the smaller one grew up in size and changed its nature to hypervascular and hyper-intensity on T2-weighted image of MRI. These hypervascular tumors increased in number and in size rapidly. The specimens obtained with tumor biopsy revealed epithelioid tumor cells positive for HMB45 immunohistochemical stain with and without brown pigment, and the tumors were diagnosed as melanoma. The patient underwent transcatheter arterial chemoembolization with cisplatin and epirubicin hydrochloride, and subsequent transcatheter arterial infusion chemotherapy with cisplatin, nimustine and dacarbazine. Unfortunately, however, the tumor rapidly progressed and she died. We discuss the imaging of the melanoma metastasized to the liver with the estimation of doubling time (DT) of the tumors.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Cellular Function, Graduate School of Medical and Dental Science, Niigata University, 757 Asahimachi-Dori 1, Niigata City, Niigata 951-8122, Japan; Department of Internal Medicine, Sannocho Hospital, 2-30 Honcho 5, Sanjo City, Niigata 955-0071, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Waguri
authors.forename: Akira
authors.initials: A
authors.lastname: Yoshimura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Suda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamura
authors.forename: Masato
authors.initials: M
authors.lastname: Igarashi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Honma
authors.forename: Toru
authors.initials: T
authors.lastname: Takahashi
authors.forename: Minoru
authors.initials: M
authors.lastname: Nomoto
authors.forename: Masaru
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Aoyagi