title: Relationship between bone resorption and adrenal sex steroids and their derivatives in oophorectomized women.
abstract: OBJECTIVE
  To clarify the role of adrenal sex steroids and their derivatives on bone resorption in oophorectomized women.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University.
  
  
  METHODS
  Forty-eight women who were within one year of bilateral oophorectomy were recruited for this study.
  
  
  METHODS
  None of the subjects were treated with the drugs affecting bone metabolism.
  
  
  METHODS
  Urinary deoxypyridinoline (Dpyr) as marker of bone resorption and serum DHEAS, androstenedione (A-dione), testosterone (T) and estrone (E1) levels as adrenal sex steroids and their derivatives.
  
  
  RESULTS
  There was an inverse correlation between urinary Dpyr and serum concentrations of E1, DHEAS, or A-dione. There was no significant relationship between urinary Dpyr and T.
  
  
  CONCLUSIONS
  These results suggest that adrenal steroids and their derivatives may influence the bone resorption in oophorectomized women.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. nozaki@med.kyushu-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Nozaki
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Nakano
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000652:urine; D000735:Androstenedione / Q000097:blood*; D001862:Bone Resorption / Q000097:blood* / Q000652:urine; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D004970:Estrone / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010052:Ovariectomy; D013739:Testosterone / Q000097:blood
chemical_list: D000596:Amino Acids; D004970:Estrone; D013739:Testosterone; D000735:Androstenedione; D019314:Dehydroepiandrosterone Sulfate; C036020:deoxypyridinoline; D003404:Creatinine