title: Plantar hyperhidrosis and pitted keratolysis treated with botulinum toxin injection.
abstract: BACKGROUND
  Sulcate plantare keratolysis or pitted keratolysis (plantar keratolysis sulcatum) is a disease that is commonly found in tropical countries. Patients have also reported plantar hyperhidrosis.
  
  
  OBJECTIVE
  Two patients with pitted keratolysis resistant to topical and systemic treatments are described.
  
  
  METHODS
  Both patients were injected with botulinum toxin distributed evenly through the plantar extension.
  
  
  RESULTS
  The response to the treatment was excellent despite using a low dose of botulinum toxin with the plantar keratolysis healing completely.
  
  
  CONCLUSIONS
  Hyperhidrosis may be considered the major etiologic factor for pitted keratolysis that does not respond to treatment.
authors.affiliation: General Hospital of the Medical School of the University of São Paulo, São Paulo, Brazil. tamurab@uol.com.br
authors.forename: Bhertha M
authors.initials: BM
authors.lastname: Tamura
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: Cucé
authors.forename: Raquel Leão
authors.initials: RL
authors.lastname: Souza
authors.forename: Jacob
authors.initials: J
authors.lastname: Levites
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D005533:Foot Dermatoses / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D006945:Hyperhidrosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D007271:Injections, Intradermal; D008297:Male
chemical_list: D003879:Dermatologic Agents; D019274:Botulinum Toxins, Type A