title: Deep-seated, well differentiated lipomatous tumors of the chest wall and extremities: the role of cytogenetics in classification and prognostication.
abstract: BACKGROUND
  Intramuscular lipomas and atypical lipomatous tumors (ALT) are common deep-seated lipomatous tumors of the chest wall and extremities. Distinguishing between these two entities can be difficult based on histologic analysis alone. However, the cytogenetic profiles of ALT and intramuscular lipomas are distinct. Correct classification is important, because aggressive local disease recurrence occurs more frequently in patients with ALT than in patients with intramuscular lipoma. The authors examined their single institutional experience and correlated their classification with clinical features and outcome.
  
  
  METHODS
  In the current study, 106 patients with deep-seated, well differentiated adipose tumors of the chest wall and extremities were classified as having ALT or intramuscular lipoma using a combined approach of histology and cytogenetics, if available. The classification was correlated with clinicopathologic features and follow-up data.
  
  
  RESULTS
  Fifty-five patients were classified as having intramuscular lipoma and 51 were classified as having ALT. Classification did not correlate with age and gender (P = 0.28 and P = 0.96, respectively). Intramuscular lipomas were smaller than ALTs (P < 0.0001), but there was significant overlap between the 2 groups. ALT occurred preferentially in the lower extremity (P < 0.0009). Four percent of patients with intramuscular lipomas and 27% of patients with ALTs developed local disease recurrence (P = 0.0006). Disease recurrence did not correlate with patient age at diagnosis, patient gender, tumor size, and tumor location (P = 0.45, P = 0.26, P = 0.49, and P = 0.28, respectively). Within the subset of patients with ALTs, disease recurrence did not correlate with patient age at diagnosis, patient gender, or tumor location (P = 0.38, P = 0.54, and P = 0.86, respectively).
  
  
  CONCLUSIONS
  Classification of deep-seated, well differentiated lipomatous tumors of the extremities and chest wall using a combined approach of histology and cytogenetics correlated well with biologic behavior/disease recurrence. This combined approach is advocated to better stratify patients for treatment purposes and follow-up.
authors.affiliation: Department of Anatomic Pathology, University of Washington Medical Center, Seattle, Washington 98195, USA.
authors.forename: Mikelle D
authors.initials: MD
authors.lastname: Bassett
authors.forename: Scott M
authors.initials: SM
authors.lastname: Schuetze
authors.forename: Christine
authors.initials: C
authors.lastname: Disteche
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Norwood
authors.forename: Karen
authors.initials: K
authors.lastname: Swisshelm
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Chen
authors.forename: James
authors.initials: J
authors.lastname: Bruckner
authors.forename: Ernest U
authors.initials: EU
authors.lastname: Conrad
authors.forename: Brian P
authors.initials: BP
authors.lastname: Rubin
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003582:Cytogenetics; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008080:Liposarcoma / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D035002:Lower Extremity; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology*; D009367:Neoplasm Staging; D011336:Probability; D011379:Prognosis; D012042:Registries; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D012983:Soft Tissue Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D035441:Thoracic Wall / Q000473:pathology*; D034941:Upper Extremity