Development and validation of computational models of cellular interaction.
In this paper we take the view that computational models of biological systems should satisfy two conditions - they should be able to predict function at a systems biology level, and robust techniques of validation against biological models must be available. A modelling paradigm for developing a predictive computational model of cellular interaction is described, and methods of providing robust validation against biological models are explored, followed by a consideration of software issues.
Smallwood
R H
RH
Department of Computer Science, University of Sheffield, 211 Portobello Street, Sheffield, S1 4DP, UK.
Holcombe
W M L
WM
Walker
D C
DC
D000818:Animals; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D004848:Epithelium / Q000502:physiology; D008954:Models, Biological; D012984:Software