The somite segmentation clock: it takes a licking and keeps on ticking.
This primer describes molecular mechanisms critical for somite segmentation clock function. In addition, two investigators of the segmentation clock, Olivier Pourquie, and Yun-Jin Jiang, give their perspectives on current research and on the future of the field.
Kiefer
Julie C
JC
Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. julie.kiefer@hci.utah.edu
D000818:Animals; D019521:Body Patterning; D002642:Chick Embryo; D015509:Developmental Biology; D047108:Embryonic Development; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000378:metabolism; D051880:Receptors, Notch; D019170:Somites / Q000502:physiology*
C496456:FGF8 protein, human; D018398:Homeodomain Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; C064045:delta protein; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors