Follicular carcinoma of the thyroid with poorly differentiated component presenting with an ileal osteoblastic metastasis.
A 4-year old history of left hip pain brought a 41-year-old women to the surgery clinic where an osteoblastic tumor in the ileum and a thyroid nodule were diagnosed. Incisional biopsy of the ileal lesion showed a metastatic carcinoma, possibly with neuroendocrine differentiation. The thyroid nodule was a follicular carcinoma with progression to insular carcinoma. In retrospect the histologic aspect of the ileal metastasis was identical to that of the insular areas in the thyroid carcinoma. In summary, a patient is described with an osteoblastic metastasis, derived from the insular component of a dedifferentiated follicular carcinoma of the thyroid.
Vanhaverbeke
Gerd
G
Department of Endocrinology, Universitaire Ziekenhuizen, Leuven, Belgium. gerd.vanhaverbeke@uz.kuleuven.ac.be
D018263:Adenocarcinoma, Follicular / Q000473:pathology*; D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary*; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007085:Ilium / Q000473:pathology*; D010006:Osteoblasts / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000473:pathology*