Focus on vascular pharmacology.
At the joint meeting of the British Pharmacological Society and the Danish Society for Pharmacology and Toxicology, held July 6-8, 2004, in Bath, United Kingdom, the focus was vascular pharmacology. In the symposium on signaling pathways in vascular muscle, the topics included were the molecular structure of G-protein-coupled receptors, phosphoinositides and other lipid messengers, the regulation of vascular contractility by cyclic nucleotides, Ca(2+) channels in the kidney vasculature, conducted vascular responses and intracellular signaling in smooth muscle cell growth. Endothelium-derived hyperpolarizing factor was the subject of a symposium and many of the communications. There was discussion whether epoxyeicosatrienoic acids, K(+), C-type natriuretic peptide, hydrogen peroxide or gap junction were endothelium-derived hyperpolarizing factor. In the J.R. Vane Medal Lecture, Prof. P. Vanhoutte discussed endothelial dysfunction, and in the Anglo-Nordic Lecture, Prof. M. Mulvany discussed the pharmacology of hypertension. Finally, there was some discussion of whether antihypertensive drug response can be predicted on the basis of DNA microsequencing.
Doggrell
Sheila A
SA
University of Queensland, School of Biomedical Sciences, Australia. s_doggrell@yahoo.com
D000818:Animals; D001685:Biological Factors / Q000502:physiology; D002317:Cardiovascular Agents / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D015394:Molecular Structure; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D006113:United Kingdom
D001685:Biological Factors; D002317:Cardiovascular Agents; C067410:endothelium-dependent hyperpolarization factor