The potential of minocycline for neuroprotection in human neurologic disease.
Minocycline is a member of the tetracycline class of molecules with broad-spectrum antibiotic activity. The unique properties of minocycline result in increased tissue distribution when compared with the other tetracyclines. Of particular interest is the ability of minocycline to diffuse into the central nervous system at clinically effective levels. Aside from its antimicrobial properties, minocycline has been found to have beneficial effects on inflammation, microglial activation, matrix metalloproteinases, nitric oxide production, and apoptotic cell death. Concordantly, minocycline has been found to have neuroprotective effects in animal models of a number of diseases including stroke, multiple sclerosis, and Parkinson disease. The proven safety of minocycline over decades of use as an antibiotic suggests that it may have potential for development into an effective treatment of multiple neurologic conditions in humans.
Zemke
Daniel
D
Department of Neurology and Ophthalmology, Michigan State University, East Lansing, Michigan 48824, USA.
Majid
Arshad
A
D000818:Animals; D016923:Cell Death / Q000187:drug effects; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D017628:Microglia / Q000187:drug effects; D008911:Minocycline / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D009422:Nervous System Diseases / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
D018696:Neuroprotective Agents; D020782:Matrix Metalloproteinases; D008911:Minocycline