Effect of parenteral antibiotic administration on establishment of intestinal colonization by Candida glabrata in adult mice.
We examined the effect of antibiotic treatment on establishment of intestinal colonization by Candida glabrata in adult mice. Subcutaneous ceftriaxone, piperacillin-tazobactam, clindamycin, and metronidazole promoted increased density of stool colonization, whereas cefepime, levofloxacin, and aztreonam did not. These findings suggest that antibiotics that inhibit intestinal anaerobes promote C. glabrata colonization.
Pultz
Nicole J
NJ
Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA.
Stiefel
Usha
U
Ghannoum
Mahmoud
M
Helfand
Marion S
MS
Donskey
Curtis J
CJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D041221:Candida glabrata / Q000187:drug effects* / Q000254:growth & development*; D015169:Colony Count, Microbial; D005260:Female; D007279:Injections, Subcutaneous; D007422:Intestines / Q000382:microbiology*; D051379:Mice
D000900:Anti-Bacterial Agents