title: Novel adamantylated pyrimidines and their preliminary biological evaluations.
abstract: The synthesis of adamantylated pyrimidines was based on the reaction of 3-(adamantan-1-yl)-3-oxopropionic acid ethyl ester with urea, thiourea, guanidine as well as acetamidine, respectively. Then the compounds obtained were converted into respective bromo-, thio- and S-alkyl derivatives. The molecular structures for some compounds were studied by X-ray methods. The significant anticancer and antimicrobial properties of [2-(6-adamantan-1-yl-2-methylpyrimidin-4-ylthio)ethyl]dimethylamine were found.
authors.affiliation: Faculty of Chemistry, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw, Poland. orzeszkoa@delta.sggw.waw.pl
authors.forename: Barbara
authors.initials: B
authors.lastname: Orzeszko
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Kazimierczuk
authors.forename: Jan Krzysztof
authors.initials: JK
authors.lastname: Maurin
authors.forename: Agnieszka Ewa
authors.initials: AE
authors.lastname: Laudy
authors.forename: Bohdan Jerzy
authors.initials: BJ
authors.lastname: Starościak
authors.forename: Juhani
authors.initials: J
authors.lastname: Vilpo
authors.forename: Leena
authors.initials: L
authors.lastname: Vilpo
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Andrzej
authors.initials: A
authors.lastname: Orzeszko
mesh_terms: D000218:Adamantane; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011743:Pyrimidines; D000218:Adamantane