Examination of candidate genes in language disorder: a model of genetic association for treatment studies.
The purpose of this review is to provide a model for studying genetic association of response to intervention in child language disorders. In addition to a theoretical overview and review of different approaches to studying candidate genes, a specific methodology for completing this type of analysis is presented. The goal of the analysis is to provide detail beyond simple broad phenotyping for affected and nonaffected individuals and to take advantage of data yielded from concise behavioral phenotyping often available in treatment studies.
Haines
Jonathan
J
Kennedy Center Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. jonathan@phg.mc.vancerbilt.edu
Camarata
Stephen
S
D001321:Autistic Disorder / Q000235:genetics / Q000628:therapy; D002884:Chromosomes, Human, Pair 15; D002888:Chromosomes, Human, Pair 19; D002897:Chromosomes, Human, Pair 7; D005544:Forecasting; D015870:Gene Expression; D005820:Genetic Testing; D006801:Humans; D007806:Language Disorders / Q000145:classification / Q000235:genetics* / Q000628:therapy*; D008957:Models, Genetic; D010641:Phenotype; D012107:Research Design; D016896:Treatment Outcome