Molecular cytogenetic study of instability at 1q21 approximately q32 in adult acute lymphoblastic leukemia.
In the present paper, we report a molecular cytogenetic study of 1q abnormalities associated with t(8;14)(q24;q32) in an adult common B acute lymphoblastic leukemia case with FAB-L2 morphology. The use of appropriate molecular cytogenetic probes allowed us to detect 13 different subclones showing heterogeneous chromosome 1 abnormalities. A complex pattern of rearrangements consisting of translocations, duplications, and inversions was observed. Breakage-fusion-bridge cycle and jumping translocation are hypothesized to have been involved in generating the large number of aberrations we detected.
Specchia
Giorgina
G
Hematology, University of Foggia, Foggia, Italy. emadhba@cimedoc.uniba.it
Albano
Francesco
F
Anelli
Luisa
L
Zagaria
Antonella
A
Liso
Arcangelo
A
Pannunzio
Alessandra
A
Archidiacono
Nicoletta
N
Liso
Vincenzo
V
Rocchi
Mariano
M
D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology