title: Molecular cytogenetic study of instability at 1q21 approximately q32 in adult acute lymphoblastic leukemia.
abstract: In the present paper, we report a molecular cytogenetic study of 1q abnormalities associated with t(8;14)(q24;q32) in an adult common B acute lymphoblastic leukemia case with FAB-L2 morphology. The use of appropriate molecular cytogenetic probes allowed us to detect 13 different subclones showing heterogeneous chromosome 1 abnormalities. A complex pattern of rearrangements consisting of translocations, duplications, and inversions was observed. Breakage-fusion-bridge cycle and jumping translocation are hypothesized to have been involved in generating the large number of aberrations we detected.
authors.affiliation: Hematology, University of Foggia, Foggia, Italy. emadhba@cimedoc.uniba.it
authors.forename: Giorgina
authors.initials: G
authors.lastname: Specchia
authors.forename: Francesco
authors.initials: F
authors.lastname: Albano
authors.forename: Luisa
authors.initials: L
authors.lastname: Anelli
authors.forename: Antonella
authors.initials: A
authors.lastname: Zagaria
authors.forename: Arcangelo
authors.initials: A
authors.lastname: Liso
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pannunzio
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Archidiacono
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Liso
authors.forename: Mariano
authors.initials: M
authors.lastname: Rocchi
mesh_terms: D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology