Fabry disease: a study of 6 hemizygous men and 5 heterozygous women with emphasis on dermatologic manifestations.
OBJECTIVE
To determine the significance of the dermatologic and systemic abnormalities found in 11 patients with Fabry disease (FD) which is an X-linked lysosomal storage disorder caused by the partial or complete deficiency of the alpha-galactosidase A enzyme. This defect leads to the accumulation of uncleaved glycosphingolipids throughout vascular endothelium and visceral tissues.


METHODS
Case series.


METHODS
Pediatric Dermatology Division, Ramos Mejia Hospital (primary care center) and Laboratory of Neurochemistry (referral center for metabolic diseases).


METHODS
Eleven patients with FD were studied: 6 hemizygous men (mean age, 23.0 years) and 5 heterozygous women (mean age, 49.4 years).


RESULTS
Mucocutaneous angiokeratomas (AKs) were found in 5 (83%) of 6 hemizygotes and 4 (80%) of 5 heterozygotes. The AKs appeared at an average age of 13 years, affecting predominantly genitalia, back, elbows, and other frequently traumatized areas. All the hemizygotes and none of the heterozygotes suffered from hypohidrosis. Angiokeratomas on the trunk and oral mucosa without sweat abnormalities were detected in 80% of heterozygous women. All hemizygotic men presented with acral pain in childhood.


CONCLUSIONS
We emphasize the value of early recognition of AKs and hypohidrosis as diagnostic clues to FD, a severe and progressive disorder.
Larralde
Margarita
M
Pediatric Dermatology Department, Ramos Mejía Hospital, Buenos Aires, Argentina. maggie@advancedsl.com.ar
Boggio
Paula
P
Amartino
Hernán
H
Chamoles
Néstor
N
D000328:Adult; D002081:Buttocks; D003229:Conjunctival Diseases / Q000209:etiology / Q000473:pathology; D004550:Elbow; D005121:Extremities; D000795:Fabry Disease / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D005260:Female; D005835:Genitalia; D006579:Heterozygote; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010146:Pain / Q000209:etiology; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology*