[Effect of guizhi tang and its active components on the fever induced by EP3 agonist].
OBJECTIVE
To investigate the effect of Guizhi Tang and its active components on the fever induced by EP3 receptor agonist sulprostone in rats.


METHODS
The rise in body temperature evoked by a LCV(lateral cerebroventricle)-injection of sulprostone was compared with that of sulprostone induced-fever rats pretreated with Guizgi Tang and its active compounds, cinnamaldehyde, cinnamic acid and total glucosides of paeony.


RESULTS
Pretreatments with Guizhi Tang and cinnamaldehyde inhibited the rise in body temperature induced by sulprostone, while cinnamic acid tended to augment the fever. The sulprostone-induced fever was blocked by an ip pretreatment of total glucosides of paeony even below the basement.


CONCLUSIONS
Present data suggest that interruption with the down-stream events of EP3 receptor may contribute to the antipyretic action of Guizhi Tang, cinnamaldehyde and the total glucosides of paeony, while cinnamic acid may have no such effect.
Li
Cang-hai
CH
Department of Pharmacology, Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China. leech-h@etang.com
Zhou
Jun
J
Huo
Hai-ru
HR
Kang
Xu-liang
XL
Jiang
Ting-liang
TL
D000171:Acrolein / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002934:Cinnamates / Q000302:isolation & purification / Q000494:pharmacology; D015232:Dinoprostone / Q000031:analogs & derivatives; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D029596:Paeonia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D018078:Receptors, Prostaglandin E / Q000819:agonists; D058308:Receptors, Prostaglandin E, EP3 Subtype
D018712:Analgesics, Non-Narcotic; D002934:Cinnamates; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D018078:Receptors, Prostaglandin E; D058308:Receptors, Prostaglandin E, EP3 Subtype; C029010:cinnamic acid; C016767:sulprostone; D000171:Acrolein; D015232:Dinoprostone; C012843:cinnamaldehyde