title: Biological optimization of the dose in stereotactic radiotherapy of brain tumors.
abstract: The techniques of radiotherapy with a high dose gradient require several demanding choices but represent a major innovation in the radiation therapy of brain tumors. To optimize the expected outcomes in terms of effectiveness and efficacy some recent acquisitions of biological parameters of integration of the linear-quadratic model are illustrated, aimed at the progressive understanding of the role of histology, dose fractionation, timing, toxicity and combined modality therapy.
authors.affiliation: Istituto di Radiologia, Cattedra di Radioterapia, Università Cattolica del Sacro Cuore, Policlinico A Gemelli, Roma, Italy. dhrt@rm.unicatt.it
authors.forename: Mario
authors.initials: M
authors.lastname: De Santis
authors.forename: Mario
authors.initials: M
authors.lastname: Balducci
authors.forename: Andrea
authors.initials: A
authors.lastname: Simili
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Frascino
authors.forename: Daniela
authors.initials: D
authors.lastname: Giammarino
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D019583:Dose Fractionation, Radiation; D006801:Humans; D016014:Linear Models; D016634:Radiosurgery; D012062:Relative Biological Effectiveness