title: How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?
abstract: Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication.
authors.affiliation: Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9072, USA. paula.fischhaber@utsouthwestern.edu
authors.forename: Paula L
authors.initials: PL
authors.lastname: Fischhaber
authors.forename: Errol C
authors.initials: EC
authors.lastname: Friedberg
mesh_terms: D000818:Animals; D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D004259:DNA-Directed DNA Polymerase / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology; D006801:Humans; D025842:SUMO-1 Protein / Q000502:physiology; D025801:Ubiquitin / Q000502:physiology
chemical_list: D025842:SUMO-1 Protein; D025801:Ubiquitin; D004259:DNA-Directed DNA Polymerase