title: Halogen-lithium exchange reactions under in situ-quench conditions: a powerful concept for organic synthesis.
abstract: In contrast to commonly accepted routine protocols for chemical synthesis, the reactions of lithioarenes, generated either by deprotonation or halogen-lithium exchange, need not necessarily be conducted in a stepwise fashion. As this review will demonstrate, the 'in situ-quench protocol provides a powerful alternative to stepwise construction in many cases. The operational simplicity of this methodology suggests interesting applications both for library syntheses and microreactor technology.
authors.affiliation: University of Cologne, Institute for Organic Chemistry, Greinstrasse 4, D-50939 Köln, Germany.
authors.forename: Sherif
authors.initials: S
authors.lastname: El Sheikh
authors.forename: Hans-Günther
authors.initials: HG
authors.lastname: Schmalz
mesh_terms: D001895:Boron / Q000737:chemistry; D001896:Boron Compounds / Q000737:chemistry; D006219:Halogens / Q000737:chemistry*; D007202:Indicators and Reagents; D008094:Lithium / Q000737:chemistry*; D009930:Organic Chemicals / Q000138:chemical synthesis*
chemical_list: D001896:Boron Compounds; D006219:Halogens; D007202:Indicators and Reagents; D009930:Organic Chemicals; D008094:Lithium; D001895:Boron