title: Proportional odds ratio model for comparison of diagnostic tests in meta-analysis.
abstract: BACKGROUND
  Consider a meta-analysis where a 'head-to-head' comparison of diagnostic tests for a disease of interest is intended. Assume there are two or more tests available for the disease, where each test has been studied in one or more papers. Some of the papers may have studied more than one test, hence the results are not independent. Also the collection of tests studied may change from one paper to the other, hence incomplete matched groups.
  
  
  METHODS
  We propose a model, the proportional odds ratio (POR) model, which makes no assumptions about the shape of ORp, a baseline function capturing the way OR changes across papers. The POR model does not assume homogeneity of ORs, but merely specifies a relationship between the ORs of the two tests. One may expand the domain of the POR model to cover dependent studies, multiple outcomes, multiple thresholds, multi-category or continuous tests, and individual-level data.
  
  
  RESULTS
  In the paper we demonstrate how to formulate the model for a few real examples, and how to use widely available or popular statistical software (like SAS, R or S-Plus, and Stata) to fit the models, and estimate the discrimination accuracy of tests. Furthermore, we provide code for converting ORs into other measures of test performance like predictive values, post-test probabilities, and likelihood ratios, under mild conditions. Also we provide code to convert numerical results into graphical ones, like forest plots, heterogeneous ROC curves, and post test probability difference graphs.
  
  
  CONCLUSIONS
  The flexibility of POR model, coupled with ease with which it can be estimated in familiar software, suits the daily practice of meta-analysis and improves clinical decision-making.
authors.affiliation: Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Box 800717, Charlottesville, Virginia 22908, USA. mirSiadaty@virginia.edu
authors.forename: Mir Said
authors.initials: MS
authors.lastname: Siadaty
authors.forename: Jianfen
authors.initials: J
authors.lastname: Shu
mesh_terms: D003627:Data Interpretation, Statistical; D003658:Decision Making, Computer-Assisted; D003954:Diagnostic Services / Q000145:classification* / Q000706:statistics & numerical data; D006801:Humans; D015201:Meta-Analysis as Topic; D015233:Models, Statistical; D016017:Odds Ratio; D012372:ROC Curve; D012984:Software