Intravesical instillation of cidofovir in the treatment of hemorrhagic cystitis caused by adenovirus type 11 in a bone marrow transplant recipient.
Hemorrhagic cystitis that occurs late after bone marrow transplantation (BMT) in BMT recipients is often associated with adenovirus or polyomavirus BK infections. Intravesical instillation of cidofovir in a BMT recipient with intractable hemorrhagic cystitis resulted in clinical improvement. Local cidofovir therapy for viral hemorrhagic cystitis could be an alternative to intravenous administration of cidofovir.
Fanourgiakis
Panagiotis
P
Infectious Disease Department, Institute Jules Bordet, Brussels, Belgium.
Georgala
Aspasia
A
Vekemans
Marc
M
Triffet
Agnes
A
De Bruyn
Jean-Marc
JM
Duchateau
Valerie
V
Martiat
Philippe
P
De Clercq
Erik
E
Snoeck
Robert
R
Wollants
Elke
E
Rector
Annabel
A
Van Ranst
Marc
M
Aoun
Michael
M
D000256:Adenoviridae; D000258:Adenovirus Infections, Human / Q000188:drug therapy* / Q000209:etiology; D000283:Administration, Intravesical; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D001739:BK Virus; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D000077404:Cidofovir; D003556:Cystitis / Q000188:drug therapy* / Q000209:etiology / Q000821:virology; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000627:therapeutic use*
D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir