B-type natriuretic peptide and its clinical implications in heart failure.
B-type natriuretic peptide (BNP) is a cardiac neurohormone released as preproBNP and then enzymatically cleaved to N-terminal-proBNP and BNP upon ventricular myocyte stretch. Blood measurements of BNP have been used to identify patients with heart failure. Currently, BNP assay is used as a diagnostic and prognostic aid in congestive heart failure. In general, a BNP level <100 pg/mL excludes acutely decompensated heart failure. This article sorts out the literature concerning the practical use of BNP in a variety of clinical scenarios.
McCullough
Peter A
PA
Department of Medicine, Division of Cardiology, William Beaumont Hospital, 4949 Coolidge, Royal Oak, MI 48073-1026, USA. pmccullough@beaumont.edu
D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000368:Aged; D000465:Algorithms; D000553:Ambulatory Care; D001835:Body Weight; D003663:Decision Trees; D016903:Drug Monitoring / Q000379:methods / Q000592:standards; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012727:Sex Characteristics; D016896:Treatment Outcome
D020097:Natriuretic Peptide, Brain