Primary effusion lymphoma of the pericardial cavity carrying t(1;22)(q21;q11) and t(14;17)(q32;q23).
We report a case of primary effusion lymphoma (PEL) in a 75-year-old woman without human immunodeficiency virus or hepatitis C virus, which presented as fever, chest pain, and pericardial effusion. The lymphoma cells were positive for CD20 and CD79a, and were negative for CD3 and CD10. Genomic human herpes virus 8 (HHV-8) and Epstein-Barr virus were not detected in the lymphoma cells. Cytogenetic analysis showed complex abnormalities by the G-banding technique, and spectral karyotyping (SKY) analysis provided more detailed characterization of the chromosomal aberrations, including t(1;22)(q21;q11) and t(14;17)(q32;q23). We did not detect C-MYC gene rearrangement or BCL-2 expression. She was treated successfully with six courses of the CHOP regimen. The present case demonstrated a rare category of PEL that is not associated with HHV-8 or C-MYC gene rearrangement. In addition, SKY analysis disclosed cryptic chromosomal abnormalities involving 1q21 and 17q23.
Fujiwara
Tohru
T
Department of Rheumatology, Tohoku University Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai 980-8574, Japan. fujiwara-t@mail.tains.tohoku.ac.jp
Ichinohasama
Ryo
R
Miura
Ikuo
I
Sugawara
Tomohiro
T
Harigae
Hideo
H
Yokoyama
Hisayuki
H
Takahashi
Shinichiro
S
Tomiya
Yasuo
Y
Yamada
Minami
M
Ishizawa
Kenichi
K
Kameoka
Junichi
J
Sasaki
Takeshi
T
D000368:Aged; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D002886:Chromosomes, Human, Pair 17; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology; D016066:Pleural Effusion, Malignant / Q000209:etiology / Q000235:genetics*; D032681:Spectral Karyotyping; D014178:Translocation, Genetic