title: Growth factor receptor expression in orbital lymphangioma: possible therapeutic implications.
abstract: OBJECTIVE
  To examine the expression of molecules targeted by imatinib mesylate (STI571;Gleevec) and epidermal growth factor receptor (EGFR) inhibitors in orbital lymphangiomas.
  
  
  METHODS
  Retrospective observational case series.
  
  
  METHODS
  Six patients with orbital lymphangioma treated at four institutions between March 2000 and December 2002.
  
  
  METHODS
  Tissue specimens and medical records from six patients were collected. Immunohistochemical analysis was performed using antibodies against c-kit and platelet-derived growth factor receptor (PDGFR) alpha and beta and EGFR tyrosine kinase.
authors.affiliation: Ophthalmology Section, Department of Plastic Surgery, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009, USA. besmaeli@mdanderson.org
authors.forename: Bita
authors.initials: B
authors.lastname: Esmaeli
authors.forename: Victor G
authors.initials: VG
authors.lastname: Prieto
authors.forename: Russell
authors.initials: R
authors.lastname: Gonnering
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Hawes
authors.forename: Roxana
authors.initials: R
authors.lastname: Diba
authors.forename: Hossein G
authors.initials: HG
authors.lastname: Saadati
authors.forename: Todd R
authors.initials: TR
authors.lastname: Shepler
authors.forename: Zeynel
authors.initials: Z
authors.lastname: Karcioglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008202:Lymphangioma / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D009918:Orbital Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D006133:Growth Substances; D066246:ErbB Receptors; D019009:Proto-Oncogene Proteins c-kit; D020796:Receptor, Platelet-Derived Growth Factor alpha; D020797:Receptor, Platelet-Derived Growth Factor beta