[Evaluation of in vitro/in vivo correlation for three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method].
OBJECTIVE
To evaluate the in vitro/in vivo correlation for three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method.


METHODS
The characteristics of in vivo release were calculated by deconvolution method using the data of plasma concentration of three kinds of self-designed sustained-release nitrendipine formulations in healthy dogs, in which the in vivo results of nitrendipine solution after oral administrated to dogs were used as weight function. It was the compared with characteristics of in vitro release to assess the in vitro/in vivo correlations.


RESULTS
The good correlations of in vitro/in vivo were shown in three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method.


CONCLUSIONS
The deconvolution method exhibited advantage in evaluation of in vitro/in vivo correlation for self-designed sustained-release nitrendipine formulations.
Yang
Ming-shi
MS
Department of Pharmaceutics, School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang 110016, China.
You
Ben-gang
BG
Yang
Ming-hua
MH
Cun
Dong-mei
DM
Tao
An-jin
AJ
Cui
Fu-de
FD
D000284:Administration, Oral; D000818:Animals; D003692:Delayed-Action Preparations; D004285:Dogs; D008747:Methylcellulose / Q000031:analogs & derivatives*; D008863:Microspheres; D009568:Nitrendipine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011208:Powders; D020034:Silicone Gels; D013678:Technology, Pharmaceutical / Q000379:methods*
D003692:Delayed-Action Preparations; D011208:Powders; D020034:Silicone Gels; D008747:Methylcellulose; C053309:hydroxypropyl methylcellulose phthalate; D009568:Nitrendipine