Mitochondrial dynamics of survivin and "four dimensional" control of tumor cell apoptosis.
The intense investigation of cell death pathways over the past few years has uncovered elevated complexity with panoply of molecular interactions, multiple intersecting gene networks and bidirectional crosstalk among disparate cellular regulators. What has remained more elusive is how these interactions are spatially arranged in the "four dimensions" of the cell as a whole, and their true relevance to human diseases. Fresh evidence obtained with survivin has unraveled a process of dynamic subcellular shuttling that is required to inhibit apoptosis during tumor growth, with the mitochondrion playing a central, orchestrating role.
Dohi
Takehiko
T
Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Altieri
Dario C
DC
D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000235:genetics / Q000502:physiology; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D045304:Cytochromes c / Q000235:genetics / Q000502:physiology; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000502:physiology*; D008928:Mitochondria / Q000737:chemistry* / Q000502:physiology*; D008938:Mitosis / Q000235:genetics / Q000502:physiology; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology*; D021381:Protein Transport / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin; D045304:Cytochromes c; D020169:Caspases