title: Experimental infection of calves with two strains of bovine virus diarrhoea virus: certain immunological reactions.
abstract: Certain immunological responses of 4-6 month old calves experimentally inoculated with either cytopathic or non-cytopathic bovine virus diarrhoea virus (BVDV) were compared with those of uninfected control calves. The tests used to demonstrate the immunological responses were the transformation of lymphocytes by PHA mitogen, the percentage of lymphocytes with surface immunoglobulin, and the antibody titres induced by an intravenous inoculation of killed Brucella abortus. There were no significant differences between the two groups of calves and therefore, the mild experimental disease produced by BVDV did not appear to affect adversely the immunological response.
authors.affiliation: A.R.C. Institute for Research on Animal Diseases, Compton, Nr. Newbury, Berks RG16 ONN, Great Britain.
authors.forename: J
authors.initials: J
authors.lastname: Brownlie
authors.forename: P A
authors.initials: PA
authors.lastname: Nuttall
authors.forename: E J
authors.initials: EJ
authors.lastname: Stott
authors.forename: G
authors.initials: G
authors.lastname: Taylor
authors.forename: L H
authors.initials: LH
authors.lastname: Thomas
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology* / Q000821:virology; D002003:Brucella abortus / Q000276:immunology; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral / Q000145:classification / Q000276:immunology*; D007136:Immunoglobulins / Q000097:blood; D008213:Lymphocyte Activation / Q000276:immunology; D010835:Phytohemagglutinins / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D007136:Immunoglobulins; D010835:Phytohemagglutinins