Isolation of ani-hepatotoxic principle form the juice of Ecballium elaterium.
The antihepatotoxic activity of elaterium (dried juice of the fruits of Ecballium elaterium, Cucurbitaceae) and cucurbitacin B (isolated from the juice) was studied against CCl4-induced hepatotoxicity. Pre- and posttreatment with elaterium and cucurbitacin B reduced CCl4-hepatotoxicity, as shown reduction in the anormally increased sGPT levels. Posttreatment caused a significant reduction in the degree of steatosis observed inthe control group, treated only with CCl4. In conclusion, elaterium and cucurbitacin B had preventive and curative effects against CCl4-induced hepatotoxicity.
Agil
A
A
Miró
M
M
Jimenez
J
J
Aneiros
J
J
Caracuel
M D
MD
García-Granados
A
A
Navarro
M C
MC
D000410:Alanine Transaminase / Q000032:analysis; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D019662:Cucurbitaceae / Q000737:chemistry*; D005234:Fatty Liver / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D005638:Fruit / Q000737:chemistry; D008107:Liver Diseases / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D020011:Protective Agents / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000627:therapeutic use; D014315:Triterpenes / Q000627:therapeutic use*
D010936:Plant Extracts; D020011:Protective Agents; D012838:Silymarin; D014315:Triterpenes; C041246:cucurbitacin B; D002251:Carbon Tetrachloride; D000410:Alanine Transaminase