Anaplastic large cell lymphoma of the pancreas: a pediatric case and literature review.
A 13-year-old boy presented with acute abdominal pain and later became jaundiced. Medical imaging subsequently demonstrated a 7 x 8 cm pancreatic mass. Examination of a biopsy specimen obtained by open laparotomy revealed malignant lymphoma. Histology, immunohistochemistry, and cytogenetics confirmed the diagnosis of ALK1-positive anaplastic large cell lymphoma. He was treated with multiagent chemotherapy and remains in complete remission 12 months off treatment. This is the first case of primary pancreatic ALK1-positive anaplastic large cell lymphoma described in a child and shows that aggressive surgical resection of pancreatic tumors is not always necessary to achieve a cure.
Fraser
Christopher J
CJ
Children's Cancer Centre, Royal Children's Hospital, Melbourne, Australia.
Chan
Yuen F
YF
Heath
John A
JA
D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome