Transgenic animal models of tauopathies.
Tauopathies are a group of neurodegenerative disorders that include Alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) and other related diseases with prominent tau pathology. Research advances in the last several decades have characterized and defined tau neuropathologies of both neuron and glia in these diverse disorders and this has stimulated development of animal models of tauopathies. Indeed, animal models ranging from invertebrate species such as C. elegan to Drosophila melanogaster and mammalian transgenic mouse models of tauopathies have been generated and reported. This review summarizes the salient features of many of the known models of tauopathies.
Lee
Virginia M-Y
VM
University of Pennsylvania School of Medicine, Pathology, 3600 Spruce Street, HUP, 3rd Floor Maloney Building 1914104-4283, Philadelphia, PA, USA. vmylee@mail.med.upenn.edu
Kenyon
Theresa K
TK
Trojanowski
John Q
JQ
D000818:Animals; D030801:Animals, Genetically Modified; D001921:Brain / Q000473:pathology; D017173:Caenorhabditis elegans / Q000235:genetics; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D008869:Microtubule-Associated Proteins / Q000235:genetics; D024801:Tauopathies / Q000235:genetics* / Q000473:pathology; D014981:Xenopus / Q000235:genetics; D016875:tau Proteins / Q000235:genetics*
C054369:MAPT protein, human; D008869:Microtubule-Associated Proteins; D016875:tau Proteins