Notch governing mature T cell differentiation.
The differentiation of naive T cells to effector/memory T cells is regulated by a variety of factors. The recent advance of the contribution of Notch signaling in this differentiation step has provided a new path to better understand the acquisition or persistence of effector function of mature T cells. In this review, we summarize emerging and, in some points, conflicting evidence for Notch signaling on mature T cell activation and differentiation.
Tsukumo
Shin-Ichi
S
Department of Immunology and Parasitology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima, Japan.
Yasutomo
Koji
K
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D051880:Receptors, Notch; D016192:Resting Phase, Cell Cycle / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*
D008565:Membrane Proteins; D051880:Receptors, Notch