title: Fluconazole nasal spray in the treatment of allergic fungal sinusitis: a pilot study.
abstract: The authors describe a prospective pilot study designed to investigate the use of topical nasal antifungal spray in addition to systemic steroids and itraconazole in the treatment of allergic fungal sinusitis. Sixteen patients with a history of allergic fungal sinusitis were given fluconazole nasal spray and followed for 3 months. Stabilization or improvement of disease without significant side effects was observed in 12 of the 16 patients who were treated with this protocol. These results indicate that topical fluconazole application may help patients with allergic fungal sinusitis; however, a larger multicenter study with longer patient follow-up is required to validate these initial findings.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, New York Presbyterian Hospital of Columbia, USA.
authors.forename: Albert
authors.initials: A
authors.lastname: Jen
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Kacker
authors.forename: Clark
authors.initials: C
authors.lastname: Huang
authors.forename: Vijay
authors.initials: V
authors.lastname: Anand
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole