Plasma adiponectin levels in post-menopausal women receiving hormone replacement therapy.
This study aimed to evaluate the correlation between plasma adiponectin levels and plasma lipid and lipoprotein levels in post-menopausal women (PMW) receiving hormone replacement therapy (HRT). Various clinical and biochemical parameters, including plasma lipid and lipoprotein concentrations and adiponectin levels, were measured in 54 healthy PMW before and after 3 and 6 months of HRT. Control groups consisted of women aged < 40 years (n = 20) or > 60 years (n = 17). PMW had significantly lower baseline adiponectin levels compared with the younger or older control groups, but adiponectin concentrations were not significantly altered after 3 or 6 months of HRT. Adiponectin levels in PMW were positively correlated with plasma high-density lipoprotein-cholesterol levels and were negatively correlated with body mass index and triglyceride levels. Our data suggest that circulating adiponectin may contribute to lipid homeostasis in PMW. Further studies are needed to elucidate the effects of HRT and oestrogen on adiponectin levels.
Sumino
H
H
Second Department of Internal Medicine, Gunma University School of Medicine, Gunma, Japan.
Takahashi
T
T
Itoh
T
T
Kusaka
K
K
Yamakawa
J
J
Ichikawa
S
S
Kurabayashi
M
M
Kanda
T
T
D052242:Adiponectin; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001835:Body Weight; D008076:Cholesterol, HDL / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000378:metabolism; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology; D008875:Middle Aged; D017698:Postmenopause; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D052242:Adiponectin; D008076:Cholesterol, HDL; D004967:Estrogens; D036341:Intercellular Signaling Peptides and Proteins; D008074:Lipoproteins; D014280:Triglycerides; D017258:Medroxyprogesterone Acetate