Angiolipoma of the buccal mucosa: a possible role of mast cell-derived VEGF in its enhanced vascularity.
A case of angiolipoma occurring in the buccal mucosa of a 69-year-old male is described. The patient had noticed a painless mass in his buccal mucosa for 2 years. The surgically removed tumor, measuring 9 mm in diameter, was mainly located in the submucosal layer with focal expansion into the muscle layer. Histologically, the tumor was well-demarcated and composed of proliferations of mature fat cells and fibrous connective tissue containing many small blood vessels, which were evenly distributed. There was diffuse infiltration of a large number of mast cells, which were immunopositive for vascular endothelial growth factor (VEGF) especially around blood vessels, suggesting that VEGF produced by mast cells in angiolipomas plays an important role in the vascular proliferation in this particular tumor.
Ida-Yonemochi
Hiroko
H
Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Swelam
Wael
W
Saito
Chikara
C
Saku
Takashi
T
D000368:Aged; D018206:Angiolipoma / Q000098:blood supply*; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D009061:Mouth Mucosa / Q000098:blood supply; D009062:Mouth Neoplasms / Q000098:blood supply*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D042461:Vascular Endothelial Growth Factor A