title: A case of multiple sclerosis with homonymous hemianopia examined by positron emission tomography.
abstract: BACKGROUND
  To demonstrate the efficacy of positron emission tomography (PET) for examining multiple sclerosis (MS) patients with hemianopia.
  
  
  METHODS
  A 20-year-old man visited us with a complaint of left homonymous hemianopia and headache.
  
  
  METHODS
  The patient's visual acuity was 1.2 (n.c.) OD and 0.9 (1.0) OS. Magnetic resonance imaging (MRI) showed a mass in the temporoparietal lobe. A pathological diagnosis of MS was made by brain biopsy. Low glucose metabolism in the lesion and visual cortex was observed by PET with (18)F-fluorodeoxy glucose. PET with (11)C-flumazenyl revealed a reduction of (11)C-uptake in the demyelinated optic radiation, and only a slight reduction of (11)C-uptake in the primary visual cortex. The results of (11)C-flumazenyl PET suggested a slight reduction of neuronal density. In 2 years, the visual field recovered to the normal state.
  
  
  CONCLUSIONS
  PET can be a useful tool for estimating the visual outcome of patients with hemianopia in MS.
authors.affiliation: Department of Ophthalmology and Visual Science, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8591, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Murai
authors.forename: Motohiro
authors.initials: M
authors.lastname: Kiyosawa
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Shoichi
authors.initials: S
authors.lastname: Mizoguchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
authors.forename: Kinya
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Takumi
authors.initials: T
authors.lastname: Akashi
mesh_terms: D000328:Adult; D005938:Glucocorticoids / Q000627:therapeutic use; D006423:Hemianopsia / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D016896:Treatment Outcome; D014793:Visual Cortex / Q000473:pathology*; D014794:Visual Fields
chemical_list: D005938:Glucocorticoids; D019275:Radiopharmaceuticals