Nucleic acid-triggered fluorescent probe activation by the Staudinger reaction.
Highly sequence specific and sensitive detection systems for DNA or RNA in vivo would be of great use in biology and medicine for monitoring gene expression and diagnosing diseased cells. Herein we describe a new nucleic acid-triggered fluorescent probe system that is activated by a biocompatible and chemoselective Staudinger reaction.
Cai
Jianfeng
J
Department of Chemistry, Washington University, One Brookings Drive, St. Louis, Missouri 63130, USA.
Li
Xiaoxu
X
Yue
Xuan
X
Taylor
John Stephen
JS
D000085:Acetates / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D005449:Fluorenes / Q000737:chemistry; D005452:Fluoresceins / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D007700:Kinetics; D009943:Organophosphorus Compounds / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics
D000085:Acetates; D000596:Amino Acids; D005449:Fluorenes; D005452:Fluoresceins; D005456:Fluorescent Dyes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D009943:Organophosphorus Compounds; D020135:Peptide Nucleic Acids; D011355:Prodrugs; C061896:triphenylphosphine