title: A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent women.
abstract: BACKGROUND
  We performed a study to better characterize the natural history of genital human papillomavirus (HPV) infection in a cohort of closely followed adolescent women.
  
  
  METHODS
  A cohort of 60 adolescent women was followed over a 2.2-year period, on average. A median of 41.5 self-collected vaginal and clinician-obtained cervical swabs were obtained from each subject.
  
  
  RESULTS
  HPV was detected in 45.3% of all adequate specimens, by use of a polymerase chain reaction/reverse blot strip assay. Oncogenic--or high-risk (HR)--HPV types were detected in 38.6% of specimens, and nononcogenic--or low-risk (LR)--types were detected in 19.6% of specimens. During the entire study period, 49 of 60 subjects tested positive for HPV (cumulative prevalence, 81.7%). The most frequently detected HR types were HPV types 52, 16, and 59. Infections with multiple HPV types were common. The median duration of persistence of a specific HPV type was 168 days, and HR types were more persistent than LR types. Abnormal cervical cytological results occurred in 37% of the adolescent women and were significantly associated with HR HPV infection.
  
  
  CONCLUSIONS
  The cumulative prevalence of HPV infection in sexually active adolescent women is extremely high, involves numerous HPV types, and frequently results in cervical dysplasia.
authors.affiliation: Division of Infectious Diseases, Indiana University School of Medicine, 545 Barnhill Dr., Emerson Hall, Rm. 435, Indianapolis, IN 46202, USA. darbrow@iupui.edu
authors.forename: Darron R
authors.initials: DR
authors.lastname: Brown
authors.forename: Marcia L
authors.initials: ML
authors.lastname: Shew
authors.forename: Brahim
authors.initials: B
authors.lastname: Qadadri
authors.forename: Nicole
authors.initials: N
authors.lastname: Neptune
authors.forename: Maria
authors.initials: M
authors.lastname: Vargas
authors.forename: Wanzhu
authors.initials: W
authors.lastname: Tu
authors.forename: Beth E
authors.initials: BE
authors.lastname: Juliar
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Breen
authors.forename: J Dennis
authors.initials: JD
authors.lastname: Fortenberry
mesh_terms: D000293:Adolescent; D002584:Cervix Uteri / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000209:etiology / Q000821:virology; D015995:Prevalence; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000209:etiology; D002577:Uterine Cervical Diseases / Q000453:epidemiology* / Q000821:virology; D014626:Vaginal Smears