Primary cutaneous plasmacytoma after rejection of a transplanted kidney: case report and review of the literature.
Immunosuppressed organ allograft recipients are at risk of developing lymphomas and lymphoproliferative disorders as a consequence of immunosuppressive therapy and long-term antigenic stimulation from both the graft and possible viral infections. No more than 4% of the malignant tumors detected in organ recipients are plasmacytomas. Primary cutaneous plasmacytoma is a rare type of cutaneous B-cell lymphoma arising primarily in the skin. It is derived from clonally expanded plasma cells with various degrees of maturation and atypia. We report the occurrence of a solitary cutaneous plasmacytoma in a 56-year-old male patient undergoing hemodialysis after rejection of a grafted kidney. The diagnosis was made a few months after the kidney had been surgically removed. A thorough examination showed no evidence of systemic disease. Skin lesions were successfully treated with local radiotherapy. After 2 years of follow-up there were no local or systemic recurrences.
Tessari
Gianpaolo
G
Department of Dermatology, University of Verona, Verona, Italy. gtessari@tele2.it
Fabbian
Fabio
F
Colato
Chiara
C
Benedetti
Fabio
F
Franchini
Massimo
M
Ortalda
Vittorio
V
Cavallini
Lucia
L
Barba
Annalisa
A
D006084:Graft Rejection / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010954:Plasmacytoma / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology* / Q000276:immunology / Q000473:pathology
D007166:Immunosuppressive Agents