title: Nuclear factor-KappaB as a common target and activator of oncogenes in head and neck squamous cell carcinoma.
abstract: Head and neck squamous cell carcinomas exhibit alterations in cell proliferation, survival (apoptosis), migration, angiogenesis and inflammation. The transcription factor nuclear factor-KappaB integrates multiple signals and regulates expression of multiple genes involved in these phenotypic responses, suggesting the hypothesis that nuclear factor-KappaB is an important molecular switch for development of head and neck squamous cell carcinoma. Nuclear factor-KappaB has been found to be constitutively activated, and a common target and activator of oncogenes in cancer. Because of its important role, activation of nuclear factor-KappaB by the proteasome and other signal molecules may provide targets for molecular therapy of squamous cell carcinoma and other cancers.
authors.affiliation: National Institutes of Health Clinical Research Training Program, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA.
authors.forename: Angela A
authors.initials: AA
authors.lastname: Chang
authors.forename: Carter
authors.initials: C
authors.lastname: Van Waes
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008297:Male; D051379:Mice; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D009367:Neoplasm Staging; D009857:Oncogenes / Q000187:drug effects / Q000235:genetics; D011379:Prognosis; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D016328:NF-kappa B