title: Intravesical instillation of cidofovir in the treatment of hemorrhagic cystitis caused by adenovirus type 11 in a bone marrow transplant recipient.
abstract: Hemorrhagic cystitis that occurs late after bone marrow transplantation (BMT) in BMT recipients is often associated with adenovirus or polyomavirus BK infections. Intravesical instillation of cidofovir in a BMT recipient with intractable hemorrhagic cystitis resulted in clinical improvement. Local cidofovir therapy for viral hemorrhagic cystitis could be an alternative to intravenous administration of cidofovir.
authors.affiliation: Infectious Disease Department, Institute Jules Bordet, Brussels, Belgium.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Fanourgiakis
authors.forename: Aspasia
authors.initials: A
authors.lastname: Georgala
authors.forename: Marc
authors.initials: M
authors.lastname: Vekemans
authors.forename: Agnes
authors.initials: A
authors.lastname: Triffet
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: De Bruyn
authors.forename: Valerie
authors.initials: V
authors.lastname: Duchateau
authors.forename: Philippe
authors.initials: P
authors.lastname: Martiat
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Robert
authors.initials: R
authors.lastname: Snoeck
authors.forename: Elke
authors.initials: E
authors.lastname: Wollants
authors.forename: Annabel
authors.initials: A
authors.lastname: Rector
authors.forename: Marc
authors.initials: M
authors.lastname: Van Ranst
authors.forename: Michael
authors.initials: M
authors.lastname: Aoun
mesh_terms: D000256:Adenoviridae; D000258:Adenovirus Infections, Human / Q000188:drug therapy* / Q000209:etiology; D000283:Administration, Intravesical; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D001739:BK Virus; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D000077404:Cidofovir; D003556:Cystitis / Q000188:drug therapy* / Q000209:etiology / Q000821:virology; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir