title: Cardiotoxicity and neurotoxicity of high-dose continuous fluorouracil as a result of degradation compounds in the drug vials.
authors.forename: Johannes
authors.initials: J
authors.lastname: Lukaschek
authors.forename: Martin
authors.initials: M
authors.lastname: Nufer
authors.forename: Dominik
authors.initials: D
authors.lastname: Maurer
authors.forename: Maximilian
authors.initials: M
authors.lastname: Asanger
authors.forename: Hanspeter
authors.initials: H
authors.lastname: Honegger
authors.forename: Lucas
authors.initials: L
authors.lastname: Widmer
authors.forename: Myriam
authors.initials: M
authors.lastname: Malet-Martino
authors.forename: Rémi
authors.initials: R
authors.lastname: Legay
authors.forename: Robert
authors.initials: R
authors.lastname: Martino
mesh_terms: D000079:Acetaldehyde / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000737:chemistry; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use*; D001927:Brain Diseases / Q000139:chemically induced*; D002277:Carcinoma / Q000188:drug therapy; D002626:Chemistry, Pharmaceutical; D004938:Esophageal Neoplasms / Q000188:drug therapy; D005079:Excipients / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D022124:Hyperammonemia / Q000139:chemically induced*; D008297:Male; D008314:Malonates / Q000009:adverse effects*; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy; D014325:Tromethamine / Q000009:adverse effects*; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced*
chemical_list: D000964:Antimetabolites, Antineoplastic; D005079:Excipients; D008314:Malonates; C495164:fluoromalonic acid semialdehyde; D014325:Tromethamine; C075898:fluoroacetaldehyde; D000079:Acetaldehyde; D005472:Fluorouracil