title: Lewy bodies in the amygdala: increase of alpha-synuclein aggregates in neurodegenerative diseases with tau-based inclusions.
abstract: BACKGROUND
  Increased attention has been given to alpha-synuclein aggregation in nonsynucleinopathies because alpha-synuclein-containing Lewy bodies (LBs) influence symptoms. However, the spectrum of disorders in which secondary inclusions are likely to occur has not been defined. Amygdala neurons commonly develop large numbers of secondary LBs, making it a practical region for studying this phenomenon.
  
  
  OBJECTIVE
  To characterize the spectrum of diseases associated with LB formation in the amygdala of neurodegenerative disease and control cases.
  
  
  METHODS
  An autopsy series of 101 neurodegenerative disease and 34 aged control cases. Using immunohistochemistry studies, we examined the amygdala for alpha-synuclein aggregates.
  
  
  RESULTS
  Lewy bodies were often abundant in classic Pick disease, argyrophilic grain disease, Alzheimer disease, and dementia with LBs but not in cases with amygdala degeneration lacking tau-based inclusions, control cases, preclinical disease carriers, or degenerative diseases lacking pathologic involvement of the amygdala. The exposed alpha-synuclein epitopes were similar in all cases containing LBs.
  
  
  CONCLUSIONS
  Abnormal alpha-synuclein aggregation in the amygdala is disease selective, but not restricted to disorders of alpha-synuclein and beta-amyloid. Our data are compatible with the notion that tau aggregates predispose neurons to develop secondary LBs.
authors.affiliation: Department of Neurology, Drexel University College of Medicine, 3300 Henry Avenue, Philadelphia, PA 19129, USA.
authors.forename: Anca
authors.initials: A
authors.lastname: Popescu
authors.forename: Carol F
authors.initials: CF
authors.lastname: Lippa
authors.forename: Virginia M-Y
authors.initials: VM
authors.lastname: Lee
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
mesh_terms: D000679:Amygdala / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D016631:Lewy Bodies / Q000378:metabolism / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology*; D051843:Synucleins; D024801:Tauopathies / Q000378:metabolism / Q000473:pathology*; D051844:alpha-Synuclein; D016875:tau Proteins / Q000096:biosynthesis
chemical_list: D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein; D016875:tau Proteins