title: Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii.
abstract: The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-beta-lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 x MIC and 1 x MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35 degrees C.
authors.affiliation: Department of Internal Medicine and AIDS Research Institute, BK21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Choi
authors.forename: Y Soo
authors.initials: YS
authors.lastname: Park
authors.forename: C H
authors.initials: CH
authors.lastname: Cho
authors.forename: Y Seon
authors.initials: YS
authors.lastname: Park
authors.forename: S Y
authors.initials: SY
authors.lastname: Shin
authors.forename: Y G
authors.initials: YG
authors.lastname: Song
authors.forename: D
authors.initials: D
authors.lastname: Yong
authors.forename: K
authors.initials: K
authors.lastname: Lee
authors.forename: J M
authors.initials: JM
authors.lastname: Kim
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013407:Sulbactam / Q000494:pharmacology*; D013997:Time Factors; D065093:beta-Lactamase Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors; D015378:Imipenem; D013407:Sulbactam