Quassinoids can induce mitochondrial membrane depolarisation and caspase 3 activation in human cells.
Rosati
A
A
Quaranta
E
E
Ammirante
M
M
Turco
M C
MC
Leone
A
A
De Feo
V
V
D032268:Ailanthus / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins; D053148:Caspase 3; D020169:Caspases / Q000187:drug effects* / Q000378:metabolism; D045744:Cell Line, Tumor; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D019169:Jurkat Cells / Q000187:drug effects*; D008562:Membrane Glycoproteins / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D036702:Quassins / Q000302:isolation & purification / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D053221:TNF-Related Apoptosis-Inducing Ligand; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D051017:Apoptosis Regulatory Proteins; D008562:Membrane Glycoproteins; D036702:Quassins; D011994:Recombinant Proteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha; C029825:ailanthone; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases