title: [Prevalence of hepatitis B virus genotypes and the occurrence of precore mutation A-1896 and to correlate them with the clinical presentation of chronic hepatitis, in a population group of the Eastern Amazon region].
abstract: Hepatitis B virus (HBV) infection presents itself with a variety of clinical manifestations. The present work aims to describe the prevalence of HBV genotypes and the occurrence of precore mutation A-1896 in a population group of the Eastern Amazon region of Brazil and to correlate them with the clinical presentation of chronic HBV infection. 51 HBsAg carriers (HBV-DNA positive) were selected and divided into three groups: A (14 asymptomatic subjects), B (20 HBeAg positive symptomatic patients) and C (17 HBeAg negative symptomatic patients). Using an automa ed DNA sequencer ABI model 377 by sequencing for determined of genotypes and precore mutation. The results showed that the genotype A was the most commonly found (81.1%, 89.5% and 93.7% in groups A, B and C, respectively) and precore mutation A-1896 was described in 11.5% (3/26) of group A subjects. Genotype A of HBV was the most prevalent (89.1%) and low occurrence of precore mutation A-1896, both not associate with the worst outcome of the chronic infection of HBV.
authors.affiliation: Fundação Santa Casa de Misericórdia do Pará, Belém, PA. conde@libnet.com.br
authors.forename: Simone Regina Souza da Silva
authors.initials: SR
authors.lastname: Conde
authors.forename: Lizomar de Jesus Pereira
authors.initials: Lde J
authors.lastname: Móia
authors.forename: Maria Silvia Brito
authors.initials: MS
authors.lastname: Barbosa
authors.forename: Ivanete do Socorro Abarcado
authors.initials: Ido S
authors.lastname: Amaral
authors.forename: Esther Castello Branco de Mello
authors.initials: EC
authors.lastname: Miranda
authors.forename: Manoel do Carmo Pereira
authors.initials: Mdo C
authors.lastname: Soares
authors.forename: Elizabete Maria de Figueiredo
authors.initials: EM
authors.lastname: Brito
authors.forename: Olglaíze do Socorro Costa
authors.initials: Odo S
authors.lastname: Souza
authors.forename: Marialva Tereza
authors.initials: MT
authors.lastname: de Araújo
authors.forename: Sâmia
authors.initials: S
authors.lastname: Demachki
authors.forename: João Renato Pinho
authors.initials: JR
authors.lastname: Rebello
authors.forename: Michele Gomes Soares
authors.initials: MG
authors.lastname: Mesquita
authors.forename: Alberto Bertollini
authors.initials: AB
authors.lastname: Denis
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ishak
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005838:Genotype; D006512:Hepatitis B Core Antigens / Q000097:blood* / Q000235:genetics; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D015995:Prevalence; D019562:Viral Load
chemical_list: D004279:DNA, Viral; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens