title: Integration of Toll-like receptor and phagocytic signaling for tailored immunity.
abstract: Toll-like receptors (TLRs) are recruited to phagosomes and sample the contents of the compartment for microbial products. In this review, we discuss the relationship between phagocytosis and TLRs from two additional perspectives: first, TLR signaling modulates phagocytosis; second, phagocytosis modulates the consequences of TLR activation.
authors.affiliation: Institute for Systems Biology, 1441 N. 34th Street, Seattle, WA 98103, USA. dunderhill@systemsbiology.org
authors.forename: David M
authors.initials: DM
authors.lastname: Underhill
authors.forename: Benjamin
authors.initials: B
authors.lastname: Gantner
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008562:Membrane Glycoproteins / Q000502:physiology*; D010587:Phagocytosis / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology*; D011971:Receptors, Immunologic / Q000276:immunology*; D015398:Signal Transduction; D051193:Toll-Like Receptors
chemical_list: D000943:Antigens, Differentiation; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D051193:Toll-Like Receptors