Tissue inhibitor of metalloproteinase 1 regulates resistance to infection.
Tissue inhibitor of metalloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.
Lee
Marie Mei
MM
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
Yoon
Bong-June
BJ
Osiewicz
Keith
K
Preston
Michael
M
Bundy
Brian
B
van Heeckeren
Anna M
AM
Werb
Zena
Z
Soloway
Paul D
PD
D000818:Animals; D008171:Lung Diseases / Q000276:immunology; D019278:Matrix Metalloproteinase 3 / Q000502:physiology; D020780:Matrix Metalloproteinase 9 / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D011552:Pseudomonas Infections / Q000276:immunology*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000502:physiology*
D019715:Tissue Inhibitor of Metalloproteinase-1; D019278:Matrix Metalloproteinase 3; D020780:Matrix Metalloproteinase 9