Pentoxifylline does not affect nociception if administered postoperatively.
Proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1) and interleukin-6 (IL-6), act as mediators of post-injury inflammation and increase pain sensitivity. Pentoxifylline (PTX) has the property of inhibiting TNF-alpha, IL-1, and IL-6 production. Previous studies revealed that the pre-injury or preoperative administration of PTX inhibited consequent hyperalgesia or postoperative pain. The aim of the study was to determine, if postoperative PTX administration affects postoperative pain. A group of 40 patients undergoing laparotomic cholecystectomy received postoperatively PTX at 10 mg/kg or placebo directly after the termination of general anesthesia. There were no differences in postoperative pain, analgesic drug requirement or TNF-alpha and IL-6 serum levels between the groups.
Szczepanik
A M
AM
Department of General and GI Surgery, Jagiellonian University Medical College, Kopernika 40, PL 31-501 Kraków, Poland. msszczep@cyf-kr.edu.pl
Wordliczek
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Serednicki
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Siedlar
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Czupryna
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D006801:Humans; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010149:Postoperative Pain / Q000097:blood / Q000188:drug therapy*; D010431:Pentoxifylline / Q000008:administration & dosage*; D011182:Postoperative Care / Q000379:methods*
D010431:Pentoxifylline