title: Prediction of heart transplant rejection with a breath test for markers of oxidative stress.
abstract: The Heart Allograft Rejection: Detection with Breath Alkanes in Low Levels study evaluated a breath test for oxidative stress in heart transplant recipients, and we report here a mathematical model predicting the probability of grade 3 rejection. The breath test divided the heart transplant recipients into 3 groups: positive for grade 3 rejection, negative for grade 3 rejection, and intermediate. The test was 100% sensitive for grade 3 heart transplant rejection when the p value was >/=0.98, and 100% specific when the p value was </=0.058; in the intermediate group, the breath test determined the probability of grade 3 rejection and the predictive value of the result.
authors.affiliation: Menssana Research Inc., Fort Lee, New Jersey, USA. mphilips@menssanaresearch.com
authors.forename: Michael
authors.initials: M
authors.lastname: Phillips
authors.forename: John P
authors.initials: JP
authors.lastname: Boehmer
authors.forename: Renee N
authors.initials: RN
authors.lastname: Cataneo
authors.forename: Taseer
authors.initials: T
authors.lastname: Cheema
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Eisen
authors.forename: John T
authors.initials: JT
authors.lastname: Fallon
authors.forename: Peter E
authors.initials: PE
authors.lastname: Fisher
authors.forename: Alan
authors.initials: A
authors.lastname: Gass
authors.forename: Joel
authors.initials: J
authors.lastname: Greenberg
authors.forename: Jon
authors.initials: J
authors.lastname: Kobashigawa
authors.forename: Donna
authors.initials: D
authors.lastname: Mancini
authors.forename: Barry
authors.initials: B
authors.lastname: Rayburn
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Zucker
mesh_terms: D000473:Alkanes / Q000032:analysis; D001944:Breath Tests; D006084:Graft Rejection / Q000175:diagnosis*; D016027:Heart Transplantation; D006801:Humans; D008433:Mathematics; D008962:Models, Theoretical; D018384:Oxidative Stress / Q000502:physiology*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity
chemical_list: D000473:Alkanes