title: HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California.
abstract: We evaluated human leukocyte antigen (HLA)-DRB1 and -DQB1 alleles as genetic markers for Vogt-Koyanagi-Harada (VKH) disease in Mestizo patients in Southern California. Mestizo individuals with VKH disease (n = 29) at two institutions were evaluated. Typing of HLA-DRB1 and DQB1 genes was performed using DNA-based techniques. Gene frequencies were compared to Mestizo individuals living in Southern California. All patients had HLA-DRB1*01, DRB1*04, DQB1*03 or DQB1*05, or a combination of these genes. The gene frequency of combined HLA-DR4 alleles was increased when compared to controls. The frequencies of HLA-DRB1*0404 and DRB1*0407 were increased compared to controls, but were not significant after Bonferroni correction. Three patients had the HLA-DRB1*0410 allele; this allele was not found in controls. All HLA-DRB1*01 positive patients had the DRB1*0102 subtype. No HLA-DQB1 allele was significantly increased compared to controls. This study is the first to identify a possible association between HLA-DRB1*0404 and VKH disease, as well as to find DRB1*0102 and DRB1*0410 in Mestizo patients.
authors.affiliation: Ocular Inflammatory Disease Center, Jules Stein Eye Institute and Department of Ophthalmology, Los Angeles, USA. levinson@jsei.ucla.edu
authors.forename: Ralph D
authors.initials: RD
authors.lastname: Levinson
authors.forename: Robert F
authors.initials: RF
authors.lastname: See
authors.forename: Raja
authors.initials: R
authors.lastname: Rajalingam
authors.forename: Elaine F
authors.initials: EF
authors.lastname: Reed
authors.forename: Min S
authors.initials: MS
authors.lastname: Park
authors.forename: Narsing A
authors.initials: NA
authors.lastname: Rao
authors.forename: Gary N
authors.initials: GN
authors.lastname: Holland
mesh_terms: D000483:Alleles; D002140:California; D016022:Case-Control Studies; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D014607:Uveomeningoencephalitic Syndrome / Q000235:genetics* / Q000276:immunology*
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains