title: Helicobacter pylori and gastric autoimmunity.
abstract: Host specific T-cell response is critical for the outcome of Helicobacter pylori infection. In genetically susceptible individuals, H. pylori can activate gastric CD4+ Th1 cells that recognize cross-reactive epitopes shared by H. pylori proteins and self H+, K+-ATPase, leading to gastric autoimmunity via molecular mimicry.
authors.affiliation: Department of Internal Medicine, University of Florence, Viale Morgagni, 85-50134 Florence, Italy. delios@unifi.it
authors.forename: Mario Milco
authors.initials: MM
authors.lastname: D'Elios
authors.forename: Mathijs P
authors.initials: MP
authors.lastname: Bergman
authors.forename: Amedeo
authors.initials: A
authors.lastname: Amedei
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Appelmelk
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Del Prete
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D005756:Gastritis / Q000201:enzymology / Q000276:immunology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans
chemical_list: D000942:Antigens, Bacterial; D001324:Autoantigens