title: Predictors of long-term mortality and cardiac events in patients with known or suspected coronary artery disease who survive major non-cardiac surgery.
abstract: The aim of this prospective study was to assess predictors of long-term outcome in patients with documented or suspected coronary artery disease who survive major non-cardiac surgery. The impact of patients' comorbidities, pre-operative heart rate variability and postoperative increase in cardiac troponin I on all-cause mortality and major cardiac events within 2 years was explored using multivariable logistic regression. Six of 173 patients died within the first month after surgery and were excluded from the study. Thirty-four of 167 patients (20%) died 1-24 months after surgery. Independent predictors of all-cause mortality were history of congestive heart failure (odds ratio 6.4 [95%, confidence interval 1.7-24]), pre-operatively depressed heart rate variability (odds ratio 6.4 [95%, confidence interval 1.9-21]), and age > 70 years (odds ratio 4.5 [95%, confidence interval 1.2-16]). In contrast, postoperative elevation of cardiac troponin I did not independently predict all-cause mortality or major cardiac events.
authors.affiliation: Department of Anaesthesia, University Hospital Basel, CH 4031 Basel, Switzerland. mfilipovic@uhbs.ch
authors.forename: M
authors.initials: M
authors.lastname: Filipovic
authors.forename: R V
authors.initials: RV
authors.lastname: Jeger
authors.forename: T
authors.initials: T
authors.lastname: Girard
authors.forename: C
authors.initials: C
authors.lastname: Probst
authors.forename: M
authors.initials: M
authors.lastname: Pfisterer
authors.forename: L
authors.initials: L
authors.lastname: Gürke
authors.forename: W
authors.initials: W
authors.lastname: Studer
authors.forename: M D
authors.initials: MD
authors.lastname: Seeberger
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002423:Cause of Death; D003327:Coronary Disease / Q000150:complications*; D005260:Female; D006331:Heart Diseases / Q000209:etiology; D006333:Heart Failure / Q000150:complications; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013514:Surgical Procedures, Operative / Q000401:mortality; D016019:Survival Analysis; D019210:Troponin I / Q000378:metabolism
chemical_list: D015415:Biomarkers; D019210:Troponin I