title: Essential tremor: occupational exposures to manganese and organic solvents.
abstract: Occupational exposures to manganese and organic solvents cause parkinsonism as well as prominent action tremor, resembling essential tremor (ET), yet their association with ET has not been studied. These chemicals cause cerebellar pathology. Cerebellar changes have been linked with ET. Using lifetime occupational histories, the authors demonstrated that occupational exposures were similar in cases and controls, which does not support an etiologic link between occupational exposures to these chemicals and ET.
authors.affiliation: Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA. EDL2@columbia.edu
authors.forename: E D
authors.initials: ED
authors.lastname: Louis
authors.forename: L M
authors.initials: LM
authors.lastname: Applegate
authors.forename: P
authors.initials: P
authors.lastname: Factor-Litvak
authors.forename: M K
authors.initials: MK
authors.lastname: Parides
authors.forename: L
authors.initials: L
authors.lastname: Andrews
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002531:Cerebellum / Q000187:drug effects; D003237:Connecticut / Q000453:epidemiology; D020329:Essential Tremor / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008345:Manganese / Q000009:adverse effects*; D008875:Middle Aged; D009515:New Jersey / Q000453:epidemiology; D009518:New York / Q000453:epidemiology; D009784:Occupational Diseases / Q000139:chemically induced / Q000453:epidemiology; D016273:Occupational Exposure; D009930:Organic Chemicals / Q000009:adverse effects*; D012997:Solvents / Q000009:adverse effects*
chemical_list: D009930:Organic Chemicals; D012997:Solvents; D008345:Manganese