title: First synthesis of rac-(5-2H3)-alpha-CEHC, a labeled analogue of a major vitamin E metabolite.
abstract: Over the past few years, quantitative determination of alpha- and gamma-CEHC, main urinary metabolites of vitamin E, has been becoming more and more important as a key parameter in assessing oxidative stress and supplementation of tocopherols. The use of deuterated analogues of these metabolites allows their accurate determination even in complex matrixes. While preparation of gamma-CEHC-d(2) has already been described, here we report the first synthesis of alpha-CEHC-d(3) together with alpha-tocopheronolactone-d(3), its oxidation product.
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Risorgimento 35, 56126 Pisa, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Mazzini
authors.forename: Thomas
authors.initials: T
authors.lastname: Netscher
authors.forename: Piero
authors.initials: P
authors.lastname: Salvadori
mesh_terms: D002839:Chromans / Q000138:chemical synthesis / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D011422:Propionates / Q000138:chemical synthesis / Q000737:chemistry*; D014810:Vitamin E / Q000378:metabolism*
chemical_list: D002839:Chromans; D011422:Propionates; D014810:Vitamin E; C084852:2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman