title: Longitudinal decline in lung function: evaluation of interleukin-10 genetic polymorphisms in firefighters.
abstract: During annual medical monitoring, some firefighters are found to have rates of decline in forced expiratory volume in one second (FEV1) far exceeding their peers. Interleukin-10 (IL-10) suppresses inflammation, and single nucleotide polymorphisms (SNPs) in the IL-10 gene may confer variable susceptibility to more rapid decline in lung function. In 1204 firefighters with at least six annual FEV1 measurements, increased age and greater initial FEV1 were associated with more rapid decline in lung function. DNA collected from 379 of these firefighters was screened for IL-10 SNPs at -1117, -854, 919, 1668, and 1812. A statistically significant difference in decline in lung function was found based on genotyping at the 1668 SNP. Evaluation of gene polymorphisms regulating lung inflammation may help to explain some of the variation in rate of decline in lung function in firefighters.
authors.affiliation: University of Arizona, Tucson, Arizona, USA. jburgess@u.arizona.edu
authors.forename: Jefferey L
authors.initials: JL
authors.lastname: Burgess
authors.forename: Maria A
authors.initials: MA
authors.lastname: Fierro
authors.forename: R Clark
authors.initials: RC
authors.lastname: Lantz
authors.forename: Tracy A
authors.initials: TA
authors.lastname: Hysong
authors.forename: Joy E
authors.initials: JE
authors.lastname: Fleming
authors.forename: Richard
authors.initials: R
authors.lastname: Gerkin
authors.forename: Eva
authors.initials: E
authors.lastname: Hnizdo
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Conley
authors.forename: Walter
authors.initials: W
authors.lastname: Klimecki
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001483:Base Sequence; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005390:Fires; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D015994:Incidence; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009784:Occupational Diseases / Q000175:diagnosis* / Q000235:genetics; D016272:Occupational Health; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011336:Probability; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000209:etiology; D012016:Reference Values; D012129:Respiratory Function Tests; D018570:Risk Assessment
chemical_list: D005819:Genetic Markers; D016753:Interleukin-10