title: [Hepatotoxicity and pancreatitis associated with gold salts: case report].
abstract: The case of a patient, 37 years old, born and resident of Lima, suffering rheumatoid arthritis who underwent treatment with prednisone, methotrexate, and chloroquine is reported. This therapy was substituted for gold salts one month before her admission. After the third dose she presented symptoms of abdominal pain and diarrhea, itching, and jaundice, associated with asthenia and a feverish sensation. Liver biochemistry demonstrated elevated transaminase, bilirubin, alkaline phosphatase, eosinophilia, inversion of the rate albumin/globulin, higher titer of immunoglobulin G, as well as an elevation of amylase and lipase. The anatomopathological study showed cholestasis, hepatocyte ballooning, spotty necrosis, predominantly in zone 3 of the acinus. These findings where found consistent with a toxic reaction.
authors.affiliation: Dpto. del Aparato Digestivo, HNERM, EsSalud.
authors.forename: Javier
authors.initials: J
authors.lastname: Díaz
authors.forename: Milagros
authors.initials: M
authors.lastname: Dávalos
authors.forename: Rossana
authors.initials: R
authors.lastname: Román
authors.forename: Carla
authors.initials: C
authors.lastname: Bustíos
authors.forename: Eduardo
authors.initials: E
authors.lastname: Zumaeta
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001707:Biopsy, Needle; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008099:Liver / Q000473:pathology*; D050607:Organogold Compounds; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
chemical_list: D018501:Antirheumatic Agents; D050607:Organogold Compounds