Comparison of 0.1% bromfenac sodium and 0.1% pemirolast potassium for the treatment of allergic conjunctivitis.
OBJECTIVE
We compared the efficacy of a new nonsteroidal antiinflammatory drug (NSAID) eye drop, 0.1% bromfenac sodium (Bromfenac), with that of an antiallergic agent, 0.1% pemirolast potassium (Pemirolast), in the treatment of seasonal allergic conjunctivitis in Japanese patients.


METHODS
Twenty-two subjects with seasonal allergic conjunctivitis were enrolled in the study. One eye was treated with Bromfenac eye drops and the contralateral eye was treated with Pemirolast eye drops for 1 week. Subjective ocular symptoms and objective ocular signs evaluated by slit-lamp examination were scored and recorded before and after treatment.


RESULTS
Both drugs significantly decreased ocular signs after 1 week, but not symptoms. No significant differences in subjective symptoms or objective signs were observed between the two drugs. Ten patients (45.5%) selected Bromfenac as more effective, nine patients (40.9%) selected Pemirolast, and three patients found no difference in efficacy between the two drugs.


CONCLUSIONS
Bromfenac sodium is as safe and effective for the treatment of allergic conjunctivitis as pemirolast potassium.
Miyake-Kashima
Minori
M
Department of Ophthalmology, Tokyo Dental College, Chiba, Ichikawa, Japan.
Takano
Yoji
Y
Tanaka
Mari
M
Satake
Yoshiyuki
Y
Kawakita
Tetsuya
T
Dogru
Murat
M
Asano-Kato
Naoko
N
Fukagawa
Kazumi
K
Fujishima
Hiroshi
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D001577:Benzophenones / Q000008:administration & dosage / Q000627:therapeutic use*; D001969:Bromobenzenes / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D003233:Conjunctivitis, Allergic / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006633:Histamine Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011725:Pyridines / Q000008:administration & dosage / Q000627:therapeutic use*; D011744:Pyrimidinones / Q000008:administration & dosage / Q000627:therapeutic use*; D012449:Safety; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001577:Benzophenones; D001969:Bromobenzenes; D006633:Histamine Antagonists; D009883:Ophthalmic Solutions; D011725:Pyridines; D011744:Pyrimidinones; C055139:pemirolast; D007073:Immunoglobulin E; C053083:bromfenac