[Anti-mutagenesis effects of total flavonoids of Astragalus].
OBJECTIVE
To investigate the anti-mutagenic action of the total flavonoids of Astragalus (TFA).


METHODS
Three groups of concentrations of TFA and one inducer group were used. The anti-mutagenic action of TFA was studied by experiments in vitro and in vivo including miconucleolus assay, semen teraogenesis test and gene mutagenesis of V79/HGPRT.


RESULTS
TFA did not affect the weight of the mice during the experiment period. The high concentration of TFA could significantly reduce cyclohophamide-induced miconucleolus number and gene mutagenesis of V79/HGPRT compared with inducer group. However, TFA did not make statistic change in the semen teraogenesis induced by mitomycin C.


CONCLUSIONS
TFA has antimutagenesis effect.
Wang
De-qing
DQ
Department of Biochemistry, PLA General Hospital, Beijing 100853, China. deqingw@vip.sina.com
Tian
Ya-ping
YP
Song
Shu-zhen
SZ
Wang
Ling
L
D000818:Animals; D016587:Antimutagenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D027885:Astragalus propinquus / Q000737:chemistry; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D016296:Mutagenesis / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry; D013737:Testis / Q000166:cytology / Q000187:drug effects
D016587:Antimutagenic Agents; D005419:Flavonoids