Decreased plasma adiponectin concentrations in women with gestational diabetes mellitus.
OBJECTIVE
Adiponectin is an adipocyte-specific protein that has been found to be associated with insulin sensitivity and obesity. Because gestational diabetes mellitus is associated with obesity and decreased insulin sensitivity, we have analyzed plasma adiponectin levels in women with gestational diabetes mellitus.


METHODS
Twenty women with gestational diabetes mellitus and 21 unaffected women were included in the study. Plasma adiponectin levels were analyzed with the use of enzyme-linked immunosorbent assay.


RESULTS
Women with gestational diabetes mellitus were significantly older (34.3 years vs 29.4 years; P < .001) than unaffected women. Adiponectin plasma levels were significantly lower in women with gestational diabetes mellitus when compared with women without gestational diabetes mellitus (5827 +/- 1988 ng/mL vs 8085 +/- 3816 ng/mL; P = .02). Adiponectin plasma levels were correlated negatively with plasma glucose concentrations of the oral glucose tolerance test ( r > -0.38; P < .04) and correlated positively with gestational age ( r = 0.36; P = .03).


CONCLUSIONS
Our data show that decreased plasma adiponectin levels were found in women with gestational diabetes mellitus compared with unaffected women.
Worda
Christof
C
Department of Obstetrics and Gynaecology, University of Vienna Medical School, Vienna General Hospital, Waehringer Guertel 18-20, A-1090 Vienna/Austria. christof.worda@akh-wien.ac.at
Leipold
Heinz
H
Gruber
Christian
C
Kautzky-Willer
Alexandra
A
Knöfler
Martin
M
Bancher-Todesca
Dagmar
D
D052242:Adiponectin; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood / Q000378:metabolism*; D015999:Multivariate Analysis; D011247:Pregnancy; D011256:Pregnancy Outcome; D011336:Probability; D012016:Reference Values; D012044:Regression Analysis; D018570:Risk Assessment; D012720:Severity of Illness Index
D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D036341:Intercellular Signaling Peptides and Proteins