Association between human alpha 2-Heremans Schmidt glycoprotein (AHSG) polymorphism and endometriosis in Korean women.
OBJECTIVE
To evaluate the relationship between the alpha 2-Heremans Schmidt glycoprotein (AHSG) gene polymorphism and endometriosis.


METHODS
Case-control study.


METHODS
Department of Obstetrics and Gynecology, Seoul National University Hospital, Korea.


METHODS
Seventy-nine women with endometriosis and 105 women without endometriosis.


METHODS
Determination of AHSG gene polymorphism.


METHODS
Prevalence of AHSG genotypes or alleles.


RESULTS
The allele frequencies of AHSG 1 and AHSG 2 were found to be 0.69 and 0.31, respectively. The proportion of noncarriers of the AHSG 2 allele was significantly higher in women with endometriosis than in women without (55.7% vs. 39.0%). Women not carrying the AHSG 2 allele were found to have twice the risk of endometriosis than those carrying at least one copy of this allele. No significant difference was noted in the distribution of the AHSG alleles or AHSG genotypes between early stage endometriosis and late stage endometriosis.


CONCLUSIONS
Endometriosis is associated with the AHSG gene polymorphism in Korean women.
Kim
Jung Gu
JG
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. kimjg@plaza.snu.ac.kr
Kim
Hoon
H
Ku
Seung-Yup
SY
Kim
Seok Hyun
SH
Choi
Young Min
YM
Moon
Shin Yong
SY
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001798:Blood Proteins / Q000235:genetics*; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D001798:Blood Proteins; D060749:alpha-2-HS-Glycoprotein