Is plasminogen activator inhibitor-1 a cardiovascular risk factor in young women with polycystic ovary syndrome?
This study aimed to evaluate plasminogen activator inhibitor-1 (PAI-1) activity in PCOS. Thirty women with PCOS - 15 normal-weight and 15 obese - and 30 healthy women matched as a group for age and body mass index (BMI) were recruited. The homeostasis model assessment (HOMA) score was significantly elevated in obese compared with normal-weight women, in both PCOS women and controls. HOMA score was significantly higher in both PCOS groups relative to controls. After further adjustment for BMI, PAI-1 activity (IU/ml +/- SD) was significantly higher in the PCOS groups compared with controls. A significant positive correlation was found between HOMA score and BMI in PCOS and control groups. Serum PAI-1 activity was significantly related to BMI and HOMA score. When considering two BMI subgroups, there was no significant difference in the relationship between serum PAI-1 activity and HOMA score in both the control and PCOS groups. No other significant relationship was found between serum PAI-1 activity and any other hormonal or metabolic parameter. In conclusion, women with PCOS have significantly elevated PAI-1 activity independent of obesity, and it is speculated that elevated PAI-1 activity may be a factor in the increased cardiovascular morbidity seen in PCOS.
Orio
Francesco
F
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy. francescoorio@virgilio.it
Palomba
Stefano
S
Cascella
Teresa
T
Tauchmanovà
Libuse
L
Nardo
Luciano G
LG
Di Biase
Sebastiano
S
Labella
Donato
D
Russo
Tiziana
T
Savastano
Silvia
S
Tolino
Achille
A
Zullo
Fulvio
F
Colao
Annamaria
A
Lombardi
Gaetano
G
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000097:blood* / Q000401:mortality*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood / Q000401:mortality; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000401:mortality*; D012307:Risk Factors
D017395:Plasminogen Activator Inhibitor 1