Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis.
We report the history of an 8-year-old girl who was treated for suspected lung lesions of respiratory papillomatosis with Indole-3-Carbinol, local and intravenous injections of Cidofovir for 27 months. This is the first report where a complete cure of the lung lesions occurred in a child, and was sustained for at least 24 months.
de Bilderling
Georges
G
Service de Pédiatrie, Cliniques de Mont-Godinne, Université Catholique de Louvain, Yvoir, Belgium. georges.debilderling@pedi.ucl.ac.be
Bodart
Eddy
E
Lawson
Georges
G
Tuerlinckx
David
D
Remacle
Marc
M
Naesens
Lieve
L
De Clercq
Erik
E
Snoeck
Robert
R
D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002648:Child; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000627:therapeutic use*; D015552:Injections, Intralesional; D007275:Injections, Intravenous; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000821:virology; D063065:Organophosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D010212:Papilloma / Q000188:drug therapy*; D011339:Probenecid / Q000627:therapeutic use
D000998:Antiviral Agents; D007211:Indoles; D063065:Organophosphonates; D003596:Cytosine; C016517:indole-3-carbinol; D000077404:Cidofovir; D011339:Probenecid