Partial protection induced by a BHV-1 recombinant vaccine against challenge with BHV-5.
Bovine herpesvirus type 5 (BHV-5) is the causative agent of bovine herpetic encephalitis, a major concern for cattle farming in Brazil and Argentina. We recently developed a differential, gE-negative vaccine (265 gE-), based on a Brazilian BHV-1 strain. The present study was carried out to examine whether such a vaccine would confer protection to BHV-5 infections. It was concluded that the recombinant BHV-1 vaccine tested here is not capable of conferring full protection to BHV-5 challenge.
Spilki
Fernando R
FR
Laboratório de Virologia, DM-ICBS/Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Silva
Alessandra D
AD
Hübner
Silvia
S
Esteves
Paulo A
PA
Franco
Ana Cláudia
AC
Driemeier
David
D
Roehe
Paulo M
PM
D000818:Animals; D000917:Antibody Formation; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D018792:Encephalitis, Viral / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary*; D006566:Herpesviridae Infections / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary*; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D025881:Herpesvirus 5, Bovine / Q000276:immunology* / Q000472:pathogenicity*; D008590:Meningoencephalitis / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary*; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines
D014765:Viral Vaccines