New polyhydroxylated sterols stylisterols A-C and a novel 5,19-cyclosterol hatomasterol from the Okinawan marine sponge Stylissa sp.
New polyhydroxylated sterols, stylisterol A-C (1-3), and a novel 5,19-cyclosterol, hatomasterol (4) were isolated from the Okinawan sponge Stylissa sp. Structural determinations of these compounds were made by spectroscopic analysis and chemical conversion. Assessment of cytotoxicity toward HeLa cells was also determined.
Mitome
Hidemichi
H
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Shirato
Nao
N
Hoshino
Ayako
A
Miyaoka
Hiroaki
H
Yamada
Yasuji
Y
Van Soest
Rob W M
RW
D000818:Animals; D006367:HeLa Cells; D006801:Humans; D006900:Hydroxylation; D008958:Models, Molecular; D011161:Porifera / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification*
D013261:Sterols