title: [Grave's disease in children with 22q11 deletion. Report of three cases].
abstract: Hypothyroidism is a well recognized complication of 22q11.2 deletion syndrome. Auto-immune hyperthyroidism is less common. We report three patients with a 22q11.2 deletion and Graves' disease diagnosed at age 17, 14 and 11 years, respectively. The clinical and biological presentation was typical for auto-immune hyperthyroidism. Graves' disease should be periodically sought during the follow-up program of patients with 22q11.2 deletion syndrome.
authors.affiliation: Service de médecine infantile III et de génétique clinique, hôpital d'enfants, rue du Morvan, 54511 Vandoeuvre, France.
authors.forename: J
authors.initials: J
authors.lastname: Gosselin
authors.forename: B
authors.initials: B
authors.lastname: Lebon-Labich
authors.forename: H
authors.initials: H
authors.lastname: Lucron
authors.forename: F
authors.initials: F
authors.lastname: Marçon
authors.forename: B
authors.initials: B
authors.lastname: Leheup
mesh_terms: D000293:Adolescent; D000328:Adult; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006111:Graves Disease / Q000235:genetics*; D006801:Humans; D008297:Male