title: Extrapulmonary tuberculosis: clinical and epidemiologic spectrum of 636 cases.
abstract: BACKGROUND
  The aim of this study was to evaluate the percentage and characteristics of extrapulmonary tuberculosis (EPTB) cases in a Turkish industrial city, Kocaeli (population: 1,203,335) and to illustrate its extent as a serious health problem for this city and country.
  
  
  METHODS
  We investigated the results of microbiologic, radiologic, and histopathologic findings of patients with extrapulmonary tuberculosis, retrospectively, who were admitted to four Tuberculous Dispensaries between 1996 and 2000.
  
  
  RESULTS
  Six hundred thirty six cases were diagnosed with EPTB. Three hundred forty five were males (54.2%) and 291, females (45.8%). Mean age of patient cases was 22.5+/-17.1 years (range, 1-86 years); 41.4% of cases were <15 years of age and 30.9%, between 20 and 39 years of age. Contact history with tuberculosis cases was determined in 242 cases (38%); of these, 194 were <15 years of age (80.2%). The most common form of EPTB was observed to be lymph node tuberculosis (56.3%); of these cases, 256 (71.5%) had involvement in intrathoracic, 92 (25.7%) in cervical, and 10 (2.8%) in axillary lymph nodes. The second most frequent extrapulmonary form was pleural tuberculosis (31.1%). EPTB was diagnosed by histopathologic methods in 229 patients (36.0%) and by microbiologic methods in 27 (4.2%); tuberculin skin test was significantly positive (>10 mm) in 95.5% of patients. When cases were classified according to severity, 87 cases (13.7%) were found severe and 549 (86.3%) as less severe EPTB. Five hundred sixty one cases (88.2%) lived in urban areas and 75 (11.8%), in rural areas.
  
  
  CONCLUSIONS
  EPTB is very common in early adulthood in the Kocaeli region, with lymph nodes the most common localization.
authors.affiliation: Department of Chest Diseases, Kocaeli University School of Medicine, Kocaeli, Turkey. ilgazah@yahoo.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ilgazli
authors.forename: Haşim
authors.initials: H
authors.lastname: Boyaci
authors.forename: Ilknur
authors.initials: I
authors.lastname: Basyigit
authors.forename: Füsun
authors.initials: F
authors.lastname: Yildiz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D014421:Turkey / Q000453:epidemiology