Oral alveolar soft-part sarcoma: review of literature and case report with immunohistochemistry study for prognostic markers.
OBJECTIVE
To describe a case of alveolar soft-part sarcoma (ASPS) affecting the tongue of a child and to study prognostic imunohistochemical markers for the disease.


METHODS
Tissue sections were incubated with primary antibodies reactive to neuron-specific enolase (NSE), vimentin, desmin, S-100 protein, cytokeratins AE1-AE3, EMA, neurofilament, synaptophysin, and muscle-specific actin (MSA), and for prognostic markers, including Ki-67, p53, bcl-2, bax, and nm23.


RESULTS
Histologically, the tumor showed a proliferation of large polygonal cells with PAS-positive diastase-resistant intracytoplasmatic material, arranged in an alveolar growth pattern. Diffuse positive reaction for neuron specific enolase (NSE), focal reactivity for desmin and S-100 protein, strong positivity for nm23 and bax, but weak reaction for p53 and Ki-67 were found. No bcl-2-positive cells were noted.


CONCLUSIONS
These immunohistochemical findings may reflect the less aggressive behavior of ASPS in oral tissues.
do Nascimento Souza
Kelen Christine
KC
Department of General Pathology, School of Medicine, FMTM Uberaba, Brazil.
Faria
Paulo Rogério
PR
Costa
Ivan Miguel
IM
Duriguetto
Antonio Francisco
AF
Loyola
Adriano Mota
AM
D000199:Actins / Q000032:analysis; D000293:Adolescent; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D003893:Desmin / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D018396:Mucin-1 / Q000032:analysis; D054778:NM23 Nucleoside Diphosphate Kinases; D016900:Neurofilament Proteins / Q000032:analysis; D009701:Nucleoside-Diphosphate Kinase / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D018234:Sarcoma, Alveolar Soft Part / Q000473:pathology*; D016708:Synaptophysin / Q000032:analysis; D014062:Tongue Neoplasms / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D051028:bcl-2-Associated X Protein
D000199:Actins; D000951:Antigens, Neoplasm; C494826:BAX protein, human; D014408:Biomarkers, Tumor; D003893:Desmin; D019394:Ki-67 Antigen; D018396:Mucin-1; D054778:NM23 Nucleoside Diphosphate Kinases; D016900:Neurofilament Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D009418:S100 Proteins; D016708:Synaptophysin; D016159:Tumor Suppressor Protein p53; D014746:Vimentin; D051028:bcl-2-Associated X Protein; D007633:Keratins; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D010751:Phosphopyruvate Hydratase