title: An expedient synthesis of the repeating unit of the acidic polysaccharide of the bacteriolytic complex of lysoamidase.
abstract: The first synthesis of the trisaccharide repeating unit of the acidic polysaccharide of the bacteriolytic complex of lysoamidase is presented. The construction is based on a linear glycosylation strategy that starts from the reducing end and employs thio- and selenoglycosides in a highly stereoselective manner by a single set of activation conditions. The thus-formed trisaccharide is selectively deprotected and oxidised, after which a final deprotection step furnishes the desired repeating unit.
authors.affiliation: Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
authors.forename: Remy E J N
authors.initials: RE
authors.lastname: Litjens
authors.forename: René
authors.initials: R
authors.lastname: den Heeten
authors.forename: Mattie S M
authors.initials: MS
authors.lastname: Timmer
authors.forename: Herman S
authors.initials: HS
authors.lastname: Overkleeft
authors.forename: Gijsbert A
authors.initials: GA
authors.lastname: van der Marel
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000737:chemistry*; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D014974:Xanthomonas / Q000737:chemistry* / Q000201:enzymology
chemical_list: D011134:Polysaccharides; C060332:lysoamidase; D010447:Peptide Hydrolases