[Matrix metalloproteinases, C-reactive protein, and markers of thrombinemia in patients with stable angina and restenoses after percutaneous coronary interventions.].
OBJECTIVE
To elucidate relationships between blood levels of matric metalloproteinases (MMP), C-reactive protein (CRP), markers of thrombinemia, and development of restenosis after percutaneous coronary interventions (PCI) in patients with stable angina.


METHODS
Patients (n=78, mean age 55.7+/-0.9 years) after successful PCI.


METHODS
MMP-2, MMP-9, CRP, prothrombin fragments 1 and 2, thrombin-antithrombin complex and plasminogen activator inhibitor antigen were measured in blood plasma taken before PCI. Repeat coronary angiography was carried out in 31 patients 6-8 months after PCI. Exercise ECG was used for diagnosis of restenosis in other patients. More than 1 mm ST depression in same ECG leads as before PCI was used as criterion of restenosis.


RESULTS
Overall sings of restenosis were found in 28 patients (35.9%). Patients with and without restenosis had similar contents of prothrombin fragments 1 and 2, thrombin-antithrombin complex, plasminogen activator inhibitor antigen and CRP, while patients with restenosis had significantly higher levels of MMP 2 and 9 (r<0.05). At multifactorial analysis level of MMP-9 was independently related to development of restenosis.


CONCLUSIONS
Elevated level of MP-9 has predictive value in relation to development of restenosis.
Zemlianskaia
O A
OA
Cardiology Research Complex; ul. Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia.
Panchenko
E P
EP
Samko
A N
AN
Dobrovol'skiĭ
A B
AB
Levitskiĭ
I V
IV
Masenko
V P
VP
Titaeva
E V
EV
D060050:Angina, Stable; D015906:Angioplasty, Balloon, Coronary; D002097:C-Reactive Protein; D023903:Coronary Restenosis / Q000175:diagnosis; D006801:Humans; D020782:Matrix Metalloproteinases; D062645:Percutaneous Coronary Intervention
D002097:C-Reactive Protein; D020782:Matrix Metalloproteinases