Transforming growth factor-beta1 in the urine of young children with urinary tract infection.
Urinary tract infection (UTI) is a frequent cause of morbidity during the first years of life and may lead to renal insufficiency. Transforming growth factor-beta1 (TGF-beta) is both immunoregulatory and an important mediator of interstitial fibrosis. TGF-beta was detected in the urine of 52% of 48 children aged 1-24 months with a first episode of UTI (94% due to Escherichia coli) and no obstructive nephropathy compared with 0 of 20 healthy young children (P<0.001). TGF-beta was detected in the urine only during the early stage (<1 day) after initiation of treatment. It was detected more frequently (P=0.06) and in significantly higher concentrations (P=0.046) in children with a normal (99m )Tc-dimercaptosuccinic acid scan compared with those with abnormal scans performed 3-14 days after the diagnosis of UTI, suggesting a regulatory role in fibrogenesis and outcome of pyelonephritis in childhood.
Farmaki
Evangelia
E
3rd Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, 49 Konstantinoupoleos Street, Thessaloniki 54642, Greece. roilides@med.auth.gr
Papachristou
Fotis
F
Winn
Richard M
RM
Karatzas
Nicolas
N
Sotiriou
John
J
Roilides
Emmanuel
E
D002675:Child, Preschool; D005260:Female; D005355:Fibrosis / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D011704:Pyelonephritis / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000032:analysis* / Q000276:immunology*; D053773:Transforming Growth Factor beta1; D014552:Urinary Tract Infections / Q000150:complications / Q000276:immunology* / Q000652:urine
C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1