Sequential histologic analysis of the myocardium after dynamic cardiomyoplasty: a study based on right ventricular endomyocardial biopsies.
Although dynamic cardiomyoplasty may promote clinical amelioration and mild improvement in left ventricular function in selected patients, whether cardiac reverse remodeling occurs after the procedure is not clear. We did not find histologic differences among right ventricular endomyocardial biopsy specimens taken before and after the surgery at 3 time periods. This result suggests that the procedure has no effect on the microscopic structure of the right ventricular myocardium. However, because reverse remodeling does not necessarily occur concomitantly in both ventricles, our conclusion cannot be extrapolated to the left ventricular chamber.
Benvenuti
Luiz Alberto
LA
Laboratory of Pathology University of São Paulo Medical School, São Paulo, Brazil. anpluiz@incor.usp.br
Moreira
Luiz Felipe Pinho
LF
Aiello
Vera Demarchi
VD
Higuchi
Maria de Lourdes
Mde L
D000328:Adult; D001706:Biopsy; D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000601:surgery; D018421:Cardiomyoplasty; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D013318:Stroke Volume; D020257:Ventricular Remodeling