2B4 co-stimulation: NK cells and their control of adaptive immune responses.
NK cells have primarily been defined by their ability to kill infected cells, tumor cells and some normal cells expressing low levels of MHC class I molecules. NK cells have also been shown to affect adaptive immune responses by their production of both pro- and anti-inflammatory cytokines. Recently it has been shown that adaptive immune responses can be enhanced or maintained also through direct lymphocyte-lymphocyte interactions. One of these interactions was identified to occur between 2B4 and CD48, where 2B4 acted as a co-stimulatory ligand for both NK cells and T cells. In the current article, we discuss the role of 2B4 in the development of adaptive immune responses and the role of NK-T cell interactions in these responses.
Assarsson
Erika
E
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, F59, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
Kambayashi
Taku
T
Persson
Catrine M
CM
Ljunggren
Hans-Gustaf
HG
Chambers
Benedict J
BJ
D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D002450:Cell Communication / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D011971:Receptors, Immunologic / Q000502:physiology*; D000071176:Signaling Lymphocytic Activation Molecule Family; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; C084093:CD244 protein, human; C490007:Cd244a protein, mouse; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D000071176:Signaling Lymphocytic Activation Molecule Family