title: hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations.
abstract: Oxidative DNA damage caused by reactive oxygen species (ROS) generated by Helicobacter pylori (H. pylori ) infection or smoking may be a cause of gastric cancer development. 8-Hydroxydeoxyguanine (8-OHdG) formation is one of the most common types of oxidative DNA damage, while human oxoguanine glycosylase 1 (hOGG1) is responsible for repairing 8-OHdG lesions. Among several hOGG1 gene polymorphisms, the Ser-->Cys polymorphism at position 326 is related to biological function. To investigate the association between Ser326Cys hOGG1 polymorphism and gastric cancer in relation to the potential risk factors of gastric cancer and antioxidant dietary or nutrient intakes, we conducted a case-control study with 142 histologically-confirmed gastric cancer cases and 271 age, sex-matched healthy controls in Japanese populations. Overall, neither the hOGG1 Ser/Cys nor the Cys/Cys genotype was associated with risk of gastric cancer, compared with the Ser/Ser genotype. A significant interaction was observed between hOGG1 Ser/Cys or Cys/Cys genotype and atrophic gastritis (P for interaction=0.03). No significant interaction was found between hOGG1 genotype and antioxidant dietary or nutrient intakes. The results of the present study suggest that patients with atrophic gastritis in conjunction with the hOGG1 Cys allele might have a higher susceptibility to gastric cancer.
authors.affiliation: Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Tsukino
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Hanaoka
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Otani
authors.forename: Motoki
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Minatsu
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Megumi
authors.initials: M
authors.lastname: Hara
authors.forename: Syusuke
authors.initials: S
authors.lastname: Natsukawa
authors.forename: Kozo
authors.initials: K
authors.lastname: Shaura
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Koizumi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kasuga
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
mesh_terms: D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D000975:Antioxidants / Q000378:metabolism; D016022:Case-Control Studies; D004249:DNA Damage; D045647:DNA Glycosylases / Q000235:genetics*; D004032:Diet; D004781:Environmental Exposure; D005260:Female; D005757:Gastritis, Atrophic / Q000209:etiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D016481:Helicobacter Infections / Q000453:epidemiology / Q000235:genetics; D016480:Helicobacter pylori / Q000235:genetics / Q000276:immunology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000201:enzymology / Q000209:etiology*
chemical_list: D000975:Antioxidants; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human