title: Complex systems model of fatigue: integrative homoeostatic control of peripheral physiological systems during exercise in humans.
abstract: Fatigue is hypothesised as being the result of the complex interaction of multiple peripheral physiological systems and the brain. In this new model, all changes in peripheral physiological systems such as substrate depletion or metabolite accumulation act as afferent signallers which modulate control processes in the brain in a dynamic, non-linear, integrative manner.
authors.affiliation: University of Cape Town, Research Unit for Exercise Science and Sports Medicine, Sports Science of South Africa, P O Box 115, Newlands 7725, South Africa. vlambert@sports.uct.ac.za
authors.forename: E V
authors.initials: EV
authors.lastname: Lambert
authors.forename: A
authors.initials: A
authors.lastname: St Clair Gibson
authors.forename: T D
authors.initials: TD
authors.lastname: Noakes
mesh_terms: D004576:Electromyography / Q000379:methods; D015444:Exercise / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007003:Hypoglycemia / Q000503:physiopathology; D018763:Muscle Fatigue / Q000502:physiology*; D010465:Perception