[Hepatotoxicity and pancreatitis associated with gold salts: case report].
The case of a patient, 37 years old, born and resident of Lima, suffering rheumatoid arthritis who underwent treatment with prednisone, methotrexate, and chloroquine is reported. This therapy was substituted for gold salts one month before her admission. After the third dose she presented symptoms of abdominal pain and diarrhea, itching, and jaundice, associated with asthenia and a feverish sensation. Liver biochemistry demonstrated elevated transaminase, bilirubin, alkaline phosphatase, eosinophilia, inversion of the rate albumin/globulin, higher titer of immunoglobulin G, as well as an elevation of amylase and lipase. The anatomopathological study showed cholestasis, hepatocyte ballooning, spotty necrosis, predominantly in zone 3 of the acinus. These findings where found consistent with a toxic reaction.
Díaz
Javier
J
Dpto. del Aparato Digestivo, HNERM, EsSalud.
Dávalos
Milagros
M
Román
Rossana
R
Bustíos
Carla
C
Zumaeta
Eduardo
E
D000328:Adult; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001707:Biopsy, Needle; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008099:Liver / Q000473:pathology*; D050607:Organogold Compounds; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
D018501:Antirheumatic Agents; D050607:Organogold Compounds