title: Case of chronic lymphocytic leukemia with unusual chromosome aberrations.
abstract: Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome banding analysis and confirmed by fluorescence in situ hybridization analysis of interphase cells. Because of the rarity of these changes, possible molecular mechanisms associated with this karyotype are discussed.
authors.affiliation: Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Hui-Hua
authors.initials: HH
authors.lastname: Hsiao
authors.forename: Yi-Hui
authors.initials: YH
authors.lastname: Hung
authors.forename: Hui-Pin
authors.initials: HP
authors.lastname: Hsiao
authors.forename: Shih-Bin
authors.initials: SB
authors.lastname: Tseng
authors.forename: Hui-Jen
authors.initials: HJ
authors.lastname: Tsai
authors.forename: Yi-Chang
authors.initials: YC
authors.lastname: Liu
authors.forename: Ta-Chih
authors.initials: TC
authors.lastname: Liu
authors.forename: Mei-Chyn
authors.initials: MC
authors.lastname: Chao
authors.forename: Yuli
authors.initials: Y
authors.lastname: Chang
authors.forename: Sheng-Fung
authors.initials: SF
authors.lastname: Lin
mesh_terms: D000368:Aged; D002892:Chromosomes, Human, Pair 22; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D017809:Fatal Outcome; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic