Management of late intrauterine death using a combination of mifepristone and misoprostol--experience of two regimens.
OBJECTIVE
To determine the safety and effectiveness of managing intrauterine death after 24 weeks gestation using a combination of mifepristone and misoprostol.


METHODS
Two regimens are compared. Twenty-nine women (group one) were managed using a combination of oral mifepristone and vaginal/oral misoprostol. After a change in dosage and route of administration, a further 20 women were managed with oral mifepristone and vaginal misoprostol (group two).


RESULTS
All women delivered vaginally. The mean induction to delivery interval in group one was 7 h compared with 10.2 h in group two. Group two experienced fewer gastrointestinal side-effects than group one.


CONCLUSIONS
This study confirms that the combined use of mifepristone and misoprostol is a safe and effective way of managing IUD after 24 weeks gestation. Regimen one results in a shorter induction to delivery interval but is associated with a higher incidence of gastrointestinal side-effects.
Fairley
Tara E
TE
Department of Obstetrics, Princess Royal Maternity, Alexandra Parade, Glasgow, Scotland, UK. tarafairley@hotmail.com
Mackenzie
Maureen
M
Owen
Philip
P
Mackenzie
Fiona
F
D000019:Abortifacient Agents / Q000008:administration & dosage*; D036861:Delivery, Obstetric; D004359:Drug Therapy, Combination; D005260:Female; D005313:Fetal Death / Q000628:therapy*; D005865:Gestational Age; D006801:Humans; D007751:Labor, Induced; D015735:Mifepristone / Q000008:administration & dosage* / Q000009:adverse effects; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D013997:Time Factors; D016896:Treatment Outcome
D000019:Abortifacient Agents; D016595:Misoprostol; D015735:Mifepristone