title: Opportunities for detection and use of QTL influencing seasonal reproduction in sheep: a review.
abstract: Genetic improvement in traits associated with seasonal breeding in sheep is challenging because these traits have low heritabilities, are generally not expressed until late in life, are commonly recorded only in females, and are expressed only in some lambing seasons and management systems. Detection of quantitative trait loci and their use in marker-assisted selection could therefore substantially enhance selection responses. A population of sheep with an extended breeding season was developed through selection for fertility in spring matings and provides opportunities for further study of candidate genes influencing seasonal breeding. In particular, the melatonin receptor 1a gene is polymorphic in many sheep breeds and appears to influence a number of seasonal reproductive responses. In addition, a variety of clock genes have been identified in laboratory mammals and shown to influence biological rhythms. Mutations in these clock genes have been identified and shown to influence circadian periodicities and reproductive patterns in golden hamster and mouse. In sheep, expression of clock genes in the suprachaismatic nucleus and pars tuberalis (PT) suggests that "calendar" cells in the ovine PT play a role in maintaining circannual rhythms. Thus the various clock genes represent potentially important candidate genes that may be involved in control of seasonal breeding.
authors.affiliation: Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA. drnotter@vt.edu
authors.forename: David R
authors.initials: DR
authors.lastname: Notter
authors.forename: Noelle E
authors.initials: NE
authors.lastname: Cockett
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000235:genetics; D001947:Breeding / Q000379:methods*; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics*; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci; D044122:Receptor, Melatonin, MT1 / Q000235:genetics; D012098:Reproduction / Q000235:genetics*; D012621:Seasons; D012756:Sheep / Q000235:genetics*
chemical_list: D044122:Receptor, Melatonin, MT1