Serum levels of 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol in dogs with hypercalcaemia.
1,25-Dihydroxycholecalciferol (1,25-(OH)2-D3) and 25-hydroxycholecalciferol (25-OH-D3) were measured among dogs with hypercalcaemia (total serum calcium > 3.01 mmol/L) due to various causes. All values were compared to those of healthy control dogs. Serum 1,25-(OH)]2-D3 was measured by a radioimmunoassay test and serum 25-OH-D3 was measured by a protein binding assay. 1,25-(OH)2-D3 ranged from 26 to 332 pmol/L (median 110.0) in dogs with lymphoma (n = 12); from 61 to 398 pmol/L (median 248.0) in dogs with primary hyperparathyreoidism (n = 5); from 28 to 310 pmol/L (median 88.5) in dogs with chronic renal failure (n = 10); and from 60 to 239 pmol/L (median 157.5) in control dogs (n = 24). There was no significant difference in 1,25-(OH)2-D3 among dogs with different causes of hypercalcaemia. 25-OH-D3 ranged from 64 to 291 nmol/L (median 101.5) in dogs with lymphoma; from 66 to 298 nmol/L (median 91.0) in dogs with primary hyperparathyreoidism; from 35 to 184 nmol/L (median 67.0) in dogs with chronic renal failure; and from 48 to 350 nmol/L (median 306.5) in control dogs. 25-OH-D3 was significantly lower in dogs with lymphoma, primary hyperparathyroidism and chronic renal failure than in control dogs. 1,25-(OH)2-D3 and 25-OH-D3 are not predictable in dogs with hypercalcaemia.
Gerber
B
B
Clinic for Small Animal Internal Medicine, University of Zurich, Winterthurstrasse 260, CH-8057 Zurich, Switzerland.
Hauser
B
B
Reusch
C E
CE
D000818:Animals; D002112:Calcifediol / Q000097:blood*; D002117:Calcitriol / Q000097:blood*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D006961:Hyperparathyroidism / Q000097:blood / Q000662:veterinary; D007676:Kidney Failure, Chronic / Q000097:blood / Q000662:veterinary; D008223:Lymphoma / Q000097:blood / Q000662:veterinary; D008297:Male
D002117:Calcitriol; D002112:Calcifediol