title: [Short-term effect of nebivolol on the left ventricular diastolic function].
abstract: OBJECTIVE
  To determine the effects of nebivolol on diastolic functions of the left ventricle in the hypertensive patients in the early treatment period.
  
  
  METHODS
  Twenty patients with mild to moderate hypertension taking daily 5 mg of nebivolol were assessed by using Doppler echocardiography before and after 6-week drug treatment period. The results were analyzed with Wilcoxon test and p<0.05 was accepted as statistically significant value.
  
  
  RESULTS
  The arterial blood pressure and heart rate of the patients significantly decreased after 6 weeks of treatment. Statistically significant decrease was found in the peak of A wave velocity, isovolumetric relaxation time, E wave deceleration time and increase in E/A ratio with Doppler echocardiography after 6-week treatment period. No statistically significant difference was observed in the peak velocity of E wave after treatment period.
  
  
  CONCLUSIONS
  We found that nebivolol improved left ventricular diastolic function in patients with hypertension in the early term.
authors.affiliation: Department of Cardiology, Haydarpaşa Education Hospital, Gülhane Military Medical Academy, Istanbul.
authors.forename: Ergün
authors.initials: E
authors.lastname: Demiralp
authors.forename: Ejder
authors.initials: E
authors.lastname: Kardeşoğlu
authors.forename: Turgay
authors.initials: T
authors.lastname: Celik
authors.forename: Bekir Sitki
authors.initials: BS
authors.lastname: Cebeci
authors.forename: Namik
authors.initials: N
authors.lastname: Ozmen
authors.forename: Zafer
authors.initials: Z
authors.lastname: Işilak
authors.forename: Rifat Eralp
authors.initials: RE
authors.lastname: Ulusoy
authors.forename: Mehmet
authors.initials: M
authors.lastname: Dinçtürk
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001578:Benzopyrans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D015150:Echocardiography, Doppler; D004983:Ethanolamines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol; D012720:Severity of Illness Index; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D000959:Antihypertensive Agents; D001578:Benzopyrans; D004983:Ethanolamines; D000068577:Nebivolol