Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus.
Susceptibility to autoimmunity in B6.Sle1b mice is associated with extensive polymorphisms between two divergent haplotypes of the SLAM/CD2 family of genes. The B6.Sle1b-derived SLAM/CD2 family haplotype is found in many other laboratory mouse strains but only causes autoimmunity in the context of the C57Bl/6 (B6) genome. Phenotypic analyses have revealed variations in the structure and expression of several members of the SLAM/CD2 family in T and B lymphocytes from B6.Sle1b mice. T lymphocytes from B6.Sle1b mice have modified signaling responses to stimulation at 4-6 weeks of age. While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly108, a specific isoform of which is constitutively upregulated in B6.Sle1b lymphocytes.
Wandstrat
Amy E
AE
Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
Nguyen
Charles
C
Limaye
Nisha
N
Chan
Alice Y
AY
Subramanian
Srividya
S
Tian
Xiang-Hong
XH
Yim
Young-Sun
YS
Pertsemlidis
Alexander
A
Garner
Harold R
HR
Morel
Laurence
L
Wakeland
Edward K
EK
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D020296:Animals, Congenic; D015703:Antigens, CD; D015551:Autoimmunity / Q000235:genetics / Q000276:immunology; D018801:CD2 Antigens / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation; D006023:Glycoproteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011956:Receptors, Cell Surface; D017422:Sequence Analysis, DNA; D000071176:Signaling Lymphocytic Activation Molecule Family; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1
D015703:Antigens, CD; D018801:CD2 Antigens; D006023:Glycoproteins; D007136:Immunoglobulins; D011956:Receptors, Cell Surface; C000604060:SLAMF6 protein, human; D000071176:Signaling Lymphocytic Activation Molecule Family; C000604063:Slamf6 protein, mouse; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D002118:Calcium