title: Long natural history of recurrent granulosa cell tumor of the ovary 23 years after initial diagnosis: a case report and review of the literature.
abstract: BACKGROUND
  Granulosa cell tumors (GCTs) of the ovary are rare, hormonally active neoplasms characterized by endocrine manifestations, an indolent course, and late relapse.
  
  
  METHODS
  We report a case of a prolonged history of ovarian GCT managed primarily with repeat surgical resections.
  
  
  CONCLUSIONS
  This case illustrates the benefits of cytoreductive surgery for the management of recurrent disease, the use of serum tumor markers to help guide therapy, and the importance of extended follow-up.
authors.affiliation: Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA.
authors.forename: Katherine D
authors.initials: KD
authors.lastname: Crew
authors.forename: Michael H
authors.initials: MH
authors.lastname: Cohen
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Smith
authors.forename: Amy D
authors.initials: AD
authors.lastname: Tiersten
authors.forename: Nikki M
authors.initials: NM
authors.lastname: Feirt
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Hershman
mesh_terms: D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000473:pathology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery