Effect of voriconazole on a corneal abscess caused by fusarium.
OBJECTIVE
To describe a case of corneal abscess caused by Fusarium solani that did not respond to common antifungal agents.


METHODS
Case report.


RESULTS
Twenty days after accidental contact with vegetation, a 56-year-old man presented with a corneal abscess. Corneal ulceration developed and a perforating keratoplasty was performed. After a microbiological examination, the diagnosis of F. solani infection was made. Systemic and topical amphotericin B and fluconazole were prescribed, with no results. A new abscess formed on the transplanted graft and a wound leak developed. We administered topical and systemic voriconazole. No side-effects were observed. The choroidal detachment and the surgical transplant recovered completely in 20 days. A vascular leukoma developed at the site of the transplanted corneal abscess.


CONCLUSIONS
From a functional point of view, another corneal transplant will be necessary. Voriconazole was effective in treating a severe keratomycosis caused by F. solani that was resistant to other topical and systemic antifungal agents.
Polizzi
Anna
A
Department of Neurological and Visual Sciences, Section of Ophthalmology, University of Genoa, Genoa, Italy.
Siniscalchi
Cristina
C
Mastromarino
Antonio
A
Saccà
Sergio C
SC
D000038:Abscess / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D000935:Antifungal Agents / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D005670:Fusarium / Q000302:isolation & purification*; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole