Integration of Toll-like receptor and phagocytic signaling for tailored immunity.
Toll-like receptors (TLRs) are recruited to phagosomes and sample the contents of the compartment for microbial products. In this review, we discuss the relationship between phagocytosis and TLRs from two additional perspectives: first, TLR signaling modulates phagocytosis; second, phagocytosis modulates the consequences of TLR activation.
Underhill
David M
DM
Institute for Systems Biology, 1441 N. 34th Street, Seattle, WA 98103, USA. dunderhill@systemsbiology.org
Gantner
Benjamin
B
D000818:Animals; D000943:Antigens, Differentiation / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008562:Membrane Glycoproteins / Q000502:physiology*; D010587:Phagocytosis / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology*; D011971:Receptors, Immunologic / Q000276:immunology*; D015398:Signal Transduction; D051193:Toll-Like Receptors
D000943:Antigens, Differentiation; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D051193:Toll-Like Receptors