[The antiviral activity of RNAse Bacillus intermedius in experiments with mice preinfected with street rabies virus].
RNAse Bacillus intermedius, when administered once and according to 11 repeated experiments, protected the preliminarily infected CBA mice with street rabies virus (protection of 40-67%; p < 0.01-0.001). A reliable protection of Animals was registered only when RNAse was administered intramuscularly at the virus introduction spot; it was not effective, when the bacterial RNAse was injected in the brain, vein, under the skin or in muscles of a non-infected extremity. Neither did it produce any suppressive effect on the vaccinal antirabic immunity.
Gribencha
S V
SV
Potselueva
L A
LA
Barinskiĭ
I F
IF
Balandin
T G
TG
Deev
S M
SM
Leshchinskaia
I B
IB
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001407:Bacillus / Q000201:enzymology*; D007110:Immunity, Active / Q000187:drug effects; D007114:Immunization; D007273:Injections, Intramuscular; D051379:Mice; D008808:Mice, Inbred CBA; D009500:Neutralization Tests; D011818:Rabies / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D011819:Rabies Vaccines / Q000008:administration & dosage; D011820:Rabies virus / Q000187:drug effects*; D012260:Ribonucleases / Q000008:administration & dosage / Q000494:pharmacology*
D000998:Antiviral Agents; D011819:Rabies Vaccines; D012260:Ribonucleases