Use of stable isotopic tracers in studies of whole body calcium metabolism.
Stable isotopic tracers of calcium have been used to characterize the absorption of dietary calcium and the subsequent distribution of this element through the body. For a group of 7 healthy children, ages 4-14, and 7 children with osteogenesis imperfecta (OI), types I, III and IV, ages 6-17, there were no detectable differences in the fractional absorption of dietary calcium, 0.29+/-0.11 and 0.28+/-0.16, respectively. The total exchangeable pool of calcium was found to be 161+/-52 mg/kg for the healthy children and 95+/-29 mg/kg for the 3 children with Type I OI, 250+/-75 mg/kg for the 3 children with Type III OI and 216 mg/kg for the child with Type IV OI.
Yergey
A L
AL
Laboratory of Theoretical and Physical Biology and the Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
Vieira
N E
NE
Abrams
S A
SA
Marini
J
J
Goans
R E
RE
D000284:Administration, Oral; D000293:Adolescent; D001846:Bone Development / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D002127:Calcium Isotopes / Q000378:metabolism / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D006130:Growth Disorders / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007275:Injections, Intravenous; D010013:Osteogenesis Imperfecta / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D012016:Reference Values; D013054:Spectrophotometry, Atomic
D002127:Calcium Isotopes; D002118:Calcium