title: Enhancement of dissolution rate of poorly-soluble active ingredients by supercritical fluid processes. Part I: Micronization of neat particles.
abstract: In this first of two articles, we discuss some issues surrounding the dissolution rate enhancement of poorly-soluble active ingredients micronized into nano-particles using several supercritical fluid particle design processes including rapid expansion of supercritical solutions (RESS), supercritical anti-solvent (SAS) and particles from gas-saturated solutions/suspensions (PGSS). Experimental results confirm that dissolution rates do not only depend on the surface area and particle size of the processed powder, but are greatly affected by other physico-chemical characteristics such as crystal morphology and wettability that may reduce the benefit of micronization.
authors.affiliation: SEPAREX, 5, Rue Jacques Monod F-54250 Champigneulles, France. mperrut@separex.fr
authors.forename: M
authors.initials: M
authors.lastname: Perrut
authors.forename: J
authors.initials: J
authors.lastname: Jung
authors.forename: F
authors.initials: F
authors.lastname: Leboeuf
mesh_terms: D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D008863:Microspheres; D049329:Nanostructures / Q000737:chemistry; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility
chemical_list: D004364:Pharmaceutical Preparations