Anticonflict actions of aqueous extracts of flowers of Achillea millefolium L. vary according to the estrous cycle phases in Wistar rats.
Anticonflict-like effects of aqueous extract of flowers of Achillea millefolium L., a plant with purported anxiolytic actions, were studied in female Wistar rats during late proestrus or diestrus. During late proestrus (p < 0.05), control rats displayed reduced conflict behavior compared with diestrus. Diazepam (2.0 mg/kg; i.p.) reduced conflict behavior both during late proestrus (p < 0.05) or diestrus (p < 0.05). Doses of 8.0 mg/kg (p < 0.05), 10.0 mg/kg (p < 0.05) or 12.0 mg/kg (p < 0.05) of Achillea millefolium reduced conflict behavior during late proestrus. Conversely, during diestrus, only the dose of 12.0 mg/kg (p < 0.05) of Achillea millefolium L. reduced conflict behavior. In conclusion, the anticonflict-like actions of Achillea millefolium L. may vary according to the estrous cycle phase.
Molina-Hernandez
M
M
Laboratorio de Conducta, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, México. mimoli@todito.com
Tellez-Alcantara
N P
NP
Diaz
M A
MA
Perez Garcia
J
J
Olivera Lopez
J I
JI
Jaramillo
M Teresa
MT
D031162:Achillea; D000378:Agonistic Behavior / Q000187:drug effects*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D030762:Estrous Cycle; D005260:Female; D035264:Flowers; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D010936:Plant Extracts