Is one Gy equal to one Gy in chemo-radiotherapy or hormono-radiotherapy?
The biological effect induced in the cell by a fixed dose of radiotherapy (e.g. 1 Gy) can be increased, reduced or significantly altered when chemotherapeutic or hormonal agents interact. A different timing of the combination between chemo/hormonotherapy and radiotherapy may also influence the cascade of effects induced by the dose of 1 Gy. Furthermore, patient, tumor and treatment-related factors are individual parameters which should be carefully considered for their potential impact on the radiation dose.
Corvò
Renzo
R
Istituto Nazionale per la Ricerca sul Cancro, Genova. corvo@hp380.ist.unige.it
Berretta
Laura
L
Andretta
Valeria
V
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D012062:Relative Biological Effectiveness
D000970:Antineoplastic Agents