State of the science in brain tumor classification.
OBJECTIVE
To review the incidence of metastatic and primary brain tumors and the most widely used brain tumor classification systems, and to discuss discoveries advancing the understanding, classification, and grading of selected brain tumor histologies.


METHODS
Journal articles, text books, epidemiologic and statistical reports.


CONCLUSIONS
Recent advances in understanding the molecular biology of brain tumors have shown that molecular and genetic signatures may predict brain tumor behavior and may soon guide tumor classification, diagnosis, and tumor-specific treatment strategies.


CONCLUSIONS
Understanding recent advances in the molecular biology of brain tumors is important because these advances may soon guide treatment decisions. New tumor-specific therapeutic opportunities may improve outcomes as well as the care of persons with brain tumors.
Doolittle
Nancy D
ND
Department of Neurology, School of Medicine, Oregon Health and Science University, Portland 97239-3098, USA. doolittl@ohsu.edu
D001254:Astrocytoma / Q000145:classification; D014408:Biomarkers, Tumor / Q000235:genetics; D001932:Brain Neoplasms / Q000145:classification* / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000145:classification; D005826:Genetics, Medical / Q000379:methods / Q000639:trends*; D015894:Genome, Human; D005909:Glioblastoma / Q000145:classification; D006801:Humans; D015994:Incidence; D008223:Lymphoma / Q000145:classification; D008527:Medulloblastoma / Q000145:classification; D008579:Meningioma / Q000145:classification; D008967:Molecular Biology / Q000379:methods / Q000639:trends*; D009154:Mutation / Q000235:genetics; D009367:Neoplasm Staging; D009837:Oligodendroglioma / Q000145:classification; D011379:Prognosis
D014408:Biomarkers, Tumor