Effects of clozapine, olanzapine and haloperidol on ethanol-induced ascorbic acid release in mouse striatum.
The effects of clozapine, olanzapine and haloperidol on ethanol-induced striatal ascorbic acid (AA) release in mice were compared by using microdialysis coupled to high performance liquid chromatography with electrochemical detection. Ethanol (4.0 g/kg i.p.) significantly stimulated striatal AA release by about 200% of baseline in mice. Clozapine and olanzapine, two atypical neuroleptic drugs, at the dose of 1.0 mg/kg s.c., had no effect on basal AA or ethanol-induced AA release. However, both drugs, at the dose of 10 mg/kg s.c., significantly inhibited ethanol-induced AA release. In contrast, haloperidol, a typical neuroleptic drug, at the doses of 0.1-2.0 mg/kg, had no effect on both basal and ethanol-induced AA release. The present study demonstrated that similar actions were exhibited by clozapine and olanzapine, but not by haloperidol, for the regulation of ethanol-induced AA release in the mouse striatum.
Hou
Yue
Y
Department of Pharmacology, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, P.R. China.
Yang
Jing Yu
JY
Wu
Chun Fu
CF
Huang
Mei
M
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism*; D001569:Benzodiazepines / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology*; D003956:Dialysis; D000431:Ethanol / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D000077152:Olanzapine; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D014150:Antipsychotic Agents; D002492:Central Nervous System Depressants; D017366:Serotonin Receptor Agonists; D001569:Benzodiazepines; D000431:Ethanol; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D003024:Clozapine; D006220:Haloperidol; D000077152:Olanzapine; D001205:Ascorbic Acid