NPY neurons express somatostatin receptor subtype 1 in the arcuate nucleus.
The regulation of growth hormone (GH) secretion involves hypothalamic somatostatin and its specific receptors (sst1-sst5). sst1 is highly expressed in the arcuate nucleus (AN), and several data suggest that sst1 receptors are preferentially involved in the somatotropic hypothalamic network. Neuropeptide Y (NPY)-containing neurons function as direct transducers for GH feedback. Interestingly, there is an overlap in the distribution of NPY and sst1 containing cells in the AN. To determine whether these NPY cells are target for somatostatin we used a double label in situ hybridization histochemistry. Image analysis revealed that approximately 7% of NPY-hybridizing neurons coexpressed sst1 mRNA. These results further support the evidence for the direct interactions between the somatotropic axis and the neuroendocrine regulatory loops of energy homeostasis.
Fodor
Mariann
M
Department of Pediatrics, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. fodor@vumc.nl
van Elk
Eef J
EJ
Huizinga
Carla T
CT
Prins
Tamara
T
Delemarre-van de Waal
Henriette A
HA
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology*; D009478:Neuropeptide Y / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D017481:Receptors, Somatostatin / Q000235:genetics*; D014158:Transcription, Genetic
D009478:Neuropeptide Y; D012333:RNA, Messenger; D017481:Receptors, Somatostatin; C101130:somatostatin receptor type 1