title: Levels of soluble forms of ICAM and VCAM in patients with myelodysplastic syndromes and their prognostic significance.
abstract: The aim of this study was to assess circulating soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and interleukin-1beta (IL-1beta) in myelodysplastic syndromes (MDS) in order to evaluate their clinical significance. Seventy patients with untreated MDS [21 refractory anemia (RA), nine RA with ringed sideroblasts (RARS), 17 RA with excess of blasts (RAEB), 11 RAEB in transformation (RAEBt), and 12 chronic myelomonocytic leukemia (CMML)] were included in this study. Serum levels of sICAM, sVCAM, and IL-1beta were determined at diagnosis using commercially available immunoassays. In addition, 15 healthy volunteers were studied as a control group. sICAM, sVCAM, and IL-1beta serum levels were significantly higher in MDS patients in comparison with the control group (P <0.001). Patients with CMML showed the highest sICAM, sVCAM, and IL-1beta levels in comparison with other MDS-related subtypes. Furthermore significantly elevated levels of the studied parameters were detected in high-risk MDS patients (RAEB, RAEB-t, and CMML) in comparison with low-risk MDS (RA and RARS). IL-1beta was strongly correlated both to sICAM and sVCAM. In conclusion we have provided evidence that increased sICAM and sVCAM serum levels are related to MDS severity.
authors.affiliation: Haematology Unit, Third Department of Internal Medicine, Sotiria Hospital, Medical School of Athens, Athens, Greece.
authors.forename: F H
authors.initials: FH
authors.lastname: Passam
authors.forename: G
authors.initials: G
authors.lastname: Tsirakis
authors.forename: A
authors.initials: A
authors.lastname: Boula
authors.forename: A
authors.initials: A
authors.lastname: Fragou
authors.forename: I
authors.initials: I
authors.lastname: Consolas
authors.forename: A
authors.initials: A
authors.lastname: Alegakis
authors.forename: D S
authors.initials: DS
authors.lastname: Kyriakou
authors.forename: M G
authors.initials: MG
authors.lastname: Alexandrakis
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007375:Interleukin-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000175:diagnosis*; D011379:Prognosis; D012995:Solubility; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D007375:Interleukin-1; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1