Mouse brain organization revealed through direct genome-scale TF expression analysis.
In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identifed 1445 putative TFs in the mouse genome. We used in situ hybridization to map the expression of over 1000 of these TFs and TF-coregulator genes in the brains of developing mice. We found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain. We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.
Gray
Paul A
PA
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Fu
Hui
H
Luo
Ping
P
Zhao
Qing
Q
Yu
Jing
J
Ferrari
Annette
A
Tenzen
Toyoaki
T
Yuk
Dong-In
DI
Tsung
Eric F
EF
Cai
Zhaohui
Z
Alberta
John A
JA
Cheng
Le-Ping
LP
Liu
Yang
Y
Stenman
Jan M
JM
Valerius
M Todd
MT
Billings
Nathan
N
Kim
Haesun A
HA
Greenberg
Michael E
ME
McMahon
Andrew P
AP
Rowitch
David H
DH
Stiles
Charles D
CD
Ma
Qiufu
Q
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism*; D003001:Cloning, Molecular; D003342:Corpus Striatum / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D017931:DNA Primers; D016208:Databases, Factual; D020869:Gene Expression Profiling; D016678:Genome; D007031:Hypothalamus / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D017403:In Situ Hybridization; D008636:Mesencephalon / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D051379:Mice; D019579:Neocortex / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D016133:Polymerase Chain Reaction; D012249:Rhombencephalon / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D013116:Spinal Cord / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D013788:Thalamus / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*
D017931:DNA Primers; D014157:Transcription Factors