title: Cyclotron production of Ac-225 for targeted alpha therapy.
abstract: The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8 MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8 MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer.
authors.affiliation: European Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, 76125 Karlsruhe, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Apostolidis
authors.forename: R
authors.initials: R
authors.lastname: Molinet
authors.forename: J
authors.initials: J
authors.lastname: McGinley
authors.forename: K
authors.initials: K
authors.lastname: Abbas
authors.forename: J
authors.initials: J
authors.lastname: Möllenbeck
authors.forename: A
authors.initials: A
authors.lastname: Morgenstern
mesh_terms: D000186:Actinium / Q000737:chemistry* / Q000627:therapeutic use; D000512:Alpha Particles / Q000627:therapeutic use*; D017357:Cyclotrons; D009683:Nuclear Medicine / Q000379:methods*; D011522:Protons; D011878:Radiotherapy / Q000379:methods; D011883:Radium / Q000737:chemistry*
chemical_list: D011522:Protons; D000186:Actinium; D011883:Radium