title: Fungal granuloma of the brain caused by Cladosporium bantianum--a case report and review of literature.
abstract: Involvement of the brain by neurotropic, dematiaceous fungi namely Cladosporium bantianum is extremely rare. The disease is very resistant to treatment and prone for frequent relapses despite treatment with amphotericin B and flucytosine, the drugs of choice for the infection. Surgery is often required for resection of the fungal granuloma. Isolation of the fungus from the tissue specimens and its culture, showing dark colored fungal colonies clinches the diagnosis. Animal inoculation studies can provide insights to the portal of entry of the organism. We hereby report a case of fungal granuloma of the brain due to C. bantianum, which responded favorably to intensive antifungal treatment alone, with relevant review of literature.
authors.affiliation: Department of Neurology, 702, Neurosciences Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
authors.forename: Sumit
authors.initials: S
authors.lastname: Singh
authors.forename: Prabhjeet
authors.initials: P
authors.lastname: Singh
authors.forename: Chitra
authors.initials: C
authors.lastname: Sarkar
authors.forename: Vinay
authors.initials: V
authors.lastname: Goel
authors.forename: Trilochan
authors.initials: T
authors.lastname: Srivastava
authors.forename: M C
authors.initials: MC
authors.lastname: Sharma
authors.forename: Madhuri
authors.initials: M
authors.lastname: Behari
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D002963:Cladosporium; D015725:Fluconazole / Q000627:therapeutic use; D006099:Granuloma / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D006261:Headache / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D012196:Review Literature as Topic; D013194:Staining and Labeling / Q000379:methods
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole