[Feasibility of short-term antibiotic prophylaxis after pulmonary resection].
How long to administer antibiotics after lung surgery is controversial. We investigated the feasibility of short-duration cefmetazole sodium administration as antibiotic prophylaxis after lung cancer surgery. A total of 40 patients were randomized into either a short-duration prophylaxis group (n=20) that was given 4 g of cefmetazole sodium for 2 days or a long-duration patients group (n=20) that was given 14 g of cefmetazole sodium for 7 days. Daily changes in body temperature, WBC, and plasma CRP concentration were determined for 9 days after surgery. The data were compared statistically between the 2 groups. Postoperative infection occurred in 20% of patients in the short-duration group and in 30% of patients in the long-duration group. The mean hospital stay after surgery was 15.5 days in the short-duration group and 18.6 days in the long-duration group. All variables did not differ significantly between the 2 groups. Our results indicate that short-duration antibiotic administration is an effective prophylactic treatment after surgery for lung cancer.
Otani
Shin-ichi
S
Division of General Thoracic Surgery, Jichi Medical School, Tochigi, Japan.
Endo
S
S
Sato
Y
Y
Hasegawa
T
T
Saito
N
N
Sohara
Y
Y
D000368:Aged; D019072:Antibiotic Prophylaxis; D015311:Cefmetazole / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D013530:Surgical Wound Infection / Q000517:prevention & control*
D015311:Cefmetazole