An expedient synthesis of the repeating unit of the acidic polysaccharide of the bacteriolytic complex of lysoamidase.
The first synthesis of the trisaccharide repeating unit of the acidic polysaccharide of the bacteriolytic complex of lysoamidase is presented. The construction is based on a linear glycosylation strategy that starts from the reducing end and employs thio- and selenoglycosides in a highly stereoselective manner by a single set of activation conditions. The thus-formed trisaccharide is selectively deprotected and oxidised, after which a final deprotection step furnishes the desired repeating unit.
Litjens
Remy E J N
RE
Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
den Heeten
René
R
Timmer
Mattie S M
MS
Overkleeft
Herman S
HS
van der Marel
Gijsbert A
GA
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000737:chemistry*; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D014974:Xanthomonas / Q000737:chemistry* / Q000201:enzymology
D011134:Polysaccharides; C060332:lysoamidase; D010447:Peptide Hydrolases