Insulin resistance, the metabolic syndrome, and nonalcoholic fatty liver disease.
OBJECTIVE
An association of nonalcoholic fatty liver disease with the insulin-resistant metabolic syndrome has been suggested. The aim of the study was to assess the association of fatty liver to different degrees of insulin resistance and secretion.


RESULTS
The study was performed in 308 alcohol- and virus-negative consecutive patients attending a metabolic clinic, who underwent a complete clinical and biochemical work-up including oral glucose tolerance test and routine liver ultrasonography. Steatosis was graded as absent/mild, moderate, and severe. In nondiabetic subjects, a progressive (P < 0.05) increase in mean homeostasis model of insulin resistance was recorded from the group without steatosis to the groups with mild/moderate and severe steatosis. Severe steatosis was associated with the clustering of the five clinical and biochemical features proposed for the clinical diagnosis of the metabolic syndrome. Subjects with the metabolic syndrome with a more pronounced insulin resistance had a higher prevalence of severe steatosis (P < 0.01) compared with those with homeostasis model of insulin resistance below the median.


CONCLUSIONS
The findings stress the heterogeneous presentation of patients with the metabolic syndrome when the diagnosis is based on the broad Adult Treatment Panel III clinical criteria and demonstrate that those who are more insulin resistant have a higher prevalence of severe steatosis.
Angelico
F
F
IV Division of Internal Medicine, Policlinico Umberto 1, Via Antonio Nibby 8, 00161 Rome, Italy. Francesco.angelico@uniroma1.it.
Del Ben
M
M
Conti
R
R
Francioso
S
S
Feole
K
K
Fiorello
S
S
Cavallo
M G
MG
Zalunardo
B
B
Lirussi
F
F
Alessandri
C
C
Violi
F
F
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000378:metabolism; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000378:metabolism*; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D014463:Ultrasonography