title: Ultrastructural study on human placenta from intrauterine growth retardation cases.
abstract: A morphological study was performed on 27 human placentas from normal gestations (Group 1) and compared with those from eight cases of intrauterine growth restriction (IUGR) (Group 2). Semithin section light microscopy, transmission, and scanning electron microscopy were carried out on trophoblastic terminal villi, carefully identified under the stereomicroscope. In growth retardation cases, villi appear longer, thinner, and less vascularized, compared to the normal condition. Fibrinoid, an extracellular material of hematic origin, frequently fills villar stroma. The density of apical microvilli appears considerably reduced and occasional microvilli-free areas are observed in growth retardation cases. Moreover, the underlying basal membrane appears significantly thicker than that of normal syncytiotrophoblast. Recently, particular attention has been paid to apoptosis as a possible cell deletion mechanism in growth restriction. In our study, a majority of typical apoptotic features appear indifferently in both IUGR and normal pregnancy. Our data hints that growth retardation might be correlated with a complex of structural changes, suggestive of maternofetal traffic downregulation, but further studies are required to understand the underlying functional mechanisms.
authors.affiliation: Istituto di Scienze Morfologiche, Urbino University, Italia.
authors.forename: Michela
authors.initials: M
authors.lastname: Battistelli
authors.forename: Sabrina
authors.initials: S
authors.lastname: Burattini
authors.forename: Francesco
authors.initials: F
authors.lastname: Pomini
authors.forename: Maria
authors.initials: M
authors.lastname: Scavo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Caruso
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Falcieri
mesh_terms: D000328:Adult; D001485:Basement Membrane / Q000648:ultrastructure; D002824:Chorionic Villi / Q000473:pathology / Q000648:ultrastructure*; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology*; D006801:Humans; D008853:Microscopy; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008871:Microvilli / Q000648:ultrastructure; D010920:Placenta / Q000473:pathology / Q000648:ultrastructure*; D011247:Pregnancy