Identification of 7-phenylaminothieno- [3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors.
We disclose here a new class of kinase inhibitors, obtained by replacing the phenyl ring of a 3-quinolinecarbonitrile system with a thiophene ring. When suitably substituted, the resultant 7-phenylaminothieno[3,2-b]pyridine-6-carbonitrile analogues show potent inhibition of Src kinase activity.
Boschelli
Diane H
DH
Chemical and Screening Sciences and Oncology, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. bosched@wyeth.com
Wu
Biqi
B
Barrios Sosa
Ana Carolina
AC
Durutlic
Haris
H
Ye
Fei
F
Raifeld
Yuri
Y
Golas
Jennifer M
JM
Boschelli
Frank
F
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology; D019061:src-Family Kinases / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D011725:Pyridines; D013876:Thiophenes; D019061:src-Family Kinases