The interface between the practice of medical genetics and human genetic research: what every genetic counselor needs to know.
Genetic counselors have historically used human genetic research as an advanced information resource for their patients. Most commonly, this has been via access to information provided by gene identification studies in advance of commercial testing. More recently genetic counselors have been participating in human genetic research studies as part of the investigative team. This review provides a framework to help genetic counselors in research and clinical practice understand the historical perspectives, ethical principles, and federal regulations that govern the current practice of human subject research. Special consideration is given to the IRB process and unique issues in human genetic research. This overview is intended to help improve the ability of genetic counselors to act as advocates for their patients.
Markel
Dorene S
DS
Center for the Advancement of Clinical Research, Department of Medical School Administration, University of Michigan, Ann Arbor, Michigan 48109-0738, USA. markel@umich.edu
Yashar
Beverly M
BM
D005817:Genetic Counseling; D036281:Genetic Research; D020408:Health Insurance Portability and Accountability Act; D006801:Humans; D007258:Informed Consent; D010818:Practice Patterns, Physicians'; D011361:Professional Competence; D014481:United States