Influence of the absolute configuration on pharmacological activity of antihypertensive and antiarrhythmic drugs.
Chirality is a fundamental property of biological systems and reflects the underlying asymmetry of matter. Interactions of drugs with receptors, enzymes or binding sites have long been known to be stereoselective, and it is increasingly recognized that both pharmacodynamic and pharmacokinetic events contribute to the overall clinically observed stereoselectivity. The pharmacological activity may reside only in one enantiomer, while the second one may be inactive or have desirable or undesirable activity. Two isomers may be nearly identical both in qualitative and quantitative aspects of pharmacological activity. The activity of particular enantiomers may differ only at the quantitative level. It is also possible that a particular enantiomer displays qualitatively different mode of action than the second one. This review describes the influence of the absolute configuration on pharmacological activity of the selected currently used or being under investigation drugs acting on cardiovascular system, especially as the antihypertensive and antiarrhythmic agents.
Kulig
K
K
Department of Pharmacological Chemistry, Medical College, Jagiellonian University, Medyczna 9, PL 30-688, Kraków, Poland.
Nowicki
P
P
Malawska
B
B
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry* / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology; D013237:Stereoisomerism
D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents