title: Anticonflict actions of aqueous extracts of flowers of Achillea millefolium L. vary according to the estrous cycle phases in Wistar rats.
abstract: Anticonflict-like effects of aqueous extract of flowers of Achillea millefolium L., a plant with purported anxiolytic actions, were studied in female Wistar rats during late proestrus or diestrus. During late proestrus (p < 0.05), control rats displayed reduced conflict behavior compared with diestrus. Diazepam (2.0 mg/kg; i.p.) reduced conflict behavior both during late proestrus (p < 0.05) or diestrus (p < 0.05). Doses of 8.0 mg/kg (p < 0.05), 10.0 mg/kg (p < 0.05) or 12.0 mg/kg (p < 0.05) of Achillea millefolium reduced conflict behavior during late proestrus. Conversely, during diestrus, only the dose of 12.0 mg/kg (p < 0.05) of Achillea millefolium L. reduced conflict behavior. In conclusion, the anticonflict-like actions of Achillea millefolium L. may vary according to the estrous cycle phase.
authors.affiliation: Laboratorio de Conducta, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, México. mimoli@todito.com
authors.forename: M
authors.initials: M
authors.lastname: Molina-Hernandez
authors.forename: N P
authors.initials: NP
authors.lastname: Tellez-Alcantara
authors.forename: M A
authors.initials: MA
authors.lastname: Diaz
authors.forename: J
authors.initials: J
authors.lastname: Perez Garcia
authors.forename: J I
authors.initials: JI
authors.lastname: Olivera Lopez
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Jaramillo
mesh_terms: D031162:Achillea; D000378:Agonistic Behavior / Q000187:drug effects*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D030762:Estrous Cycle; D005260:Female; D035264:Flowers; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D014151:Anti-Anxiety Agents; D010936:Plant Extracts