title: Vessel maturation effects on tumour growth: validation of a computer model in implanted human ovarian carcinoma spheroids.
abstract: We analysed measurements of tumour growth, neovascular maturation and function in human epithelial ovarian carcinoma xenografts, studied noninvasively by magnetic resonance imaging. Results suggest that vascular maturation and mature and immature vessel regression occur continuously during tumour neovascularisation. Moreover, in these spheroids, a high tumour growth-rate is associated with monotonic changes in vessel density (VD) and with large proportions of mature blood vessels, whereas a lower tumour growth-rate is associated with fluctuating VD and lower proportions of mature vessels. These results corroborate a mathematical model for tumour dynamics, including vascular maturation and immature and mature vessel regression. The model predicts that rapid tumour growth may result from a high maturation-rate of neo-vasculatures, due to substantial mature VD in the microenvironment, while a slower tumour growth is an outcome of a lower background VD, leading to a lower vessel maturation-rate, larger proportion of immature vessels and, consequently, to regression-driven instabilities. The generality of these results for other tumour types should be validated.
authors.affiliation: Institute for Medical BioMathematics (IMBM), 10 Ha'Teena St., P.O. Box 282, Bene Ataroth, 60991, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Arakelyan
authors.forename: Y
authors.initials: Y
authors.lastname: Merbl
authors.forename: Z
authors.initials: Z
authors.lastname: Agur
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000254:growth & development*; D002455:Cell Division; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D008819:Mice, Nude; D008954:Models, Biological; D009389:Neovascularization, Pathologic / Q000473:pathology; D010051:Ovarian Neoplasms / Q000098:blood supply* / Q000473:pathology*; D018874:Spheroids, Cellular