[Cancer antigen 125 as a marker of ascites in patients with liver cirrhosis].
Cancer antigen 125 (CA-125) is usually used to monitor the course of epithelial ovarian cancer. It has recently been reported that liver cirrhosis is associated with elevated serum CA-125, especially in the presence of ascites. The aim of the study was to evaluate CA-125 as a marker of ascites in patients with liver cirrhosis. Seventy-two (72) patients with liver cirrhosis of different aetiology were studied. Ca-125 levels were measured in stored serum collected from the patients. Ca-125 concentrations were elevated in patients with liver cirrhosis and ascites, irrespective of patients' sex and cirrhosis aetiology. CA-125 concentrations were normal in cases of liver cirrhosis without ascites. Elevated cancer antigen 125 is a sensitive marker of cirrhotic ascites. An inappropriate use of this test in cases of liver cirrhosis in females may suggest the ovarian cancer incident and lead to unnecessary surgical intervention.
Jabłkowski
Maciej
M
Katreda Chorób Zakaźnych UM w Lodzi. m.jablkowski@pro.onet.pl
Białkowska
Jolanta
J
Koktysz
Robert
R
Bartkowiak
Jacek
J
Stankiewicz
Wanda
W
Dworniak
Daniela
D
D001201:Ascites / Q000453:epidemiology / Q000276:immunology*; D015415:Biomarkers; D018394:CA-125 Antigen / Q000276:immunology*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D018394:CA-125 Antigen