title: Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps.
abstract: Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this ancestral genome into existing mammalian genomes. Here, the recently developed Multiple Genome Rearrangement (MGR) algorithm is applied to human, mouse, cat and cattle comparative maps (with 311-470 shared markers) to impute the ancestral mammalian genome. Reconstructed ancestors consist of 70-100 conserved segments shared across the genomes that have been exchanged by rearrangement events along the ordinal lineages leading to modern species genomes. Genomic distances between species, dominated by inversions (reversals) and translocations, are presented in a first multispecies attempt using ordered mapping data to reconstruct the evolutionary exchanges that preceded modern placental mammal genomes.
authors.affiliation: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA. murphywi@mail.ncifcrf.gov
authors.forename: William J
authors.initials: WJ
authors.lastname: Murphy
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bourque
authors.forename: Glenn
authors.initials: G
authors.lastname: Tesler
authors.forename: Pavel
authors.initials: P
authors.lastname: Pevzner
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: O'Brien
mesh_terms: D000465:Algorithms; D000818:Animals; D002415:Cats / Q000235:genetics; D002417:Cattle / Q000235:genetics; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D002875:Chromosomes; D002877:Chromosomes, Human; D019295:Computational Biology; D019143:Evolution, Molecular; D005260:Female; D015321:Gene Rearrangement; D005819:Genetic Markers; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008322:Mammals / Q000235:genetics*; D051379:Mice / Q000235:genetics; D015203:Reproducibility of Results; D013045:Species Specificity; D026801:Synteny; D014178:Translocation, Genetic
chemical_list: D005819:Genetic Markers