A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study.
Plasma insulin and glucose concentrations are important quantitative phenotypes related to diabetes and the metabolic syndrome. Reports purporting to identify quantitative trait loci (QTLs) that contribute to the variation in fasting insulin and glucose concentrations are discrepant. As part of the Insulin Resistance Atherosclerosis Study (IRAS) Family Study, a genome scan was performed in African-American (n = 42) and Hispanic (n = 90) extended families to identify regions that may contain positional candidate genes for fasting insulin and fasting glucose (n = 1,604 subjects). There was significant evidence for linkage of fasting insulin to the short arm of chromosome 17 (logarithm of odds [LOD] = 3.30; 54 cM between D17S1294 and D17S1299, P = 1.0 x 10(-4)). The strongest evidence for linkage over all pedigrees for fasting glucose was also observed in this region (LOD = 1.44; 58 cM, P = 9.9 x 10(-3)). The results of this study provide impetus for future positional cloning of QTLs regulating insulin and glucose levels. Identifying genes in these regions should provide insight into the nature of genetic factors regulating plasma glucose and insulin concentrations.
Rich
Stephen S
SS
Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor MRI Center, Winston-Salem, NC 27157, USA. srich@wfubmc.edu
Bowden
Donald W
DW
Haffner
Steven M
SM
Norris
Jill M
JM
Saad
Mohammed F
MF
Mitchell
Braxton D
BD
Rotter
Jerome I
JI
Langefeld
Carl D
CD
Hedrick
Catherine C
CC
Wagenknecht
Lynne E
LE
Bergman
Richard N
RN
D001741:Black or African American / Q000235:genetics; D001161:Arteriosclerosis / Q000235:genetics; D001786:Blood Glucose / Q000235:genetics / Q000378:metabolism*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics; D005190:Family; D005215:Fasting; D040481:Genome Components / Q000235:genetics*; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000097:blood / Q000235:genetics*; D007333:Insulin Resistance; D040641:Quantitative Trait Loci; D018570:Risk Assessment; D014481:United States
D001786:Blood Glucose; D007328:Insulin