title: Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male.
abstract: We report herein a 19-year-old Japanese male with XYY syndrome who developed acute myelogenous leukemia. During three courses of cytotoxic chemotherapy, he suffered repeated hepatic and renal insufficiencies, possibly related to latent dysfunction from the XYY syndrome. The patient was treated with granulocyte colony-stimulating factor combined with etoposide, cytarabine, and busulfan (the latter adjusted to a targeting dose) followed by autologous peripheral blood stem cell transplantation. He had no severe regimen-related toxicities and is now free of leukemia.
authors.affiliation: Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Sada
authors.forename: Hideho
authors.initials: H
authors.lastname: Henzan
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ohtani
authors.forename: Ken
authors.initials: K
authors.lastname: Takase
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fukuda
authors.forename: Koji
authors.initials: K
authors.lastname: Nagafuji
authors.forename: Keita
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Takamatsu
authors.forename: Shoichi
authors.initials: S
authors.lastname: Inaba
authors.forename: Mine
authors.initials: M
authors.lastname: Harada
mesh_terms: D000328:Adult; D002066:Busulfan / Q000008:administration & dosage* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000601:surgery*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous; D014997:XYY Karyotype
chemical_list: D007166:Immunosuppressive Agents; D002066:Busulfan