title: Protective constituents against sepsis in mice from the root cortex of Paeonia suffruticosa.
abstract: The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoniflorin (5), oxypaeoniflorin (6), apiopaeonoside (7), and methyl 3-hydroxy-4-methoxybenzoate (8). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 17% for the control experiment) and reduced alanine aminotransferase level to be a half of the control value on the sepsis model induced by lipopolysaccharide/D-galactosamine.
authors.affiliation: College of Pharmacy, Yanbian University, Yanji 133000, P R China.
authors.forename: Gao
authors.initials: G
authors.lastname: Li
authors.forename: Chang-Seob
authors.initials: CS
authors.lastname: Seo
authors.forename: Kyeung-Seon
authors.initials: KS
authors.lastname: Lee
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hyun-Wook
authors.initials: HW
authors.lastname: Chang
authors.forename: Jun-Sub
authors.initials: JS
authors.lastname: Jung
authors.forename: Dong-Keun
authors.initials: DK
authors.lastname: Song
authors.forename: Jong-Keun
authors.initials: JK
authors.lastname: Son
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D029596:Paeonia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D018805:Sepsis / Q000097:blood / Q000401:mortality / Q000517:prevention & control*; D015996:Survival Rate; D013997:Time Factors
chemical_list: D010936:Plant Extracts; D000410:Alanine Transaminase