title: Fluorescence glucose detection: advances toward the ideal in vivo biosensor.
abstract: The importance of glucose monitoring for in vivo as well as for ex vivo applications has driven a vast number of scientific groups to pursue the development of an advanced glucose sensor. Such a sensor must be robust, versatile, and capable of the long-term, accurate and reproducible detection of glucose levels in various testing media. Among the different configurations and signal transduction mechanisms used, fluorescence-based glucose sensors constitute a growing class of glucose sensors represented by an increasing number of significant contributions to the field over the last few years. This manuscript reviews the progress in the development of fluorescence based glucose sensors resulting from the advances in the design of new receptor systems for glucose recognition and the utilization of new fluorescence transduction schemes.
authors.affiliation: Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Moschou
authors.forename: Bethel V
authors.initials: BV
authors.lastname: Sharma
authors.forename: Sapna K
authors.initials: SK
authors.lastname: Deo
authors.forename: Sylvia
authors.initials: S
authors.lastname: Daunert
mesh_terms: D015374:Biosensing Techniques / Q000379:methods* / Q000639:trends; D001897:Boronic Acids / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry*; D005470:Fluorometry; D001411:Geobacillus stearothermophilus / Q000201:enzymology; D005941:Glucokinase / Q000737:chemistry; D005947:Glucose / Q000032:analysis*; D005949:Glucose Oxidase / Q000737:chemistry; D006801:Humans; D037102:Lectins / Q000737:chemistry; D015394:Molecular Structure; D008991:Monitoring, Physiologic / Q000379:methods; D009004:Monosaccharide Transport Proteins / Q000737:chemistry / Q000235:genetics; D009154:Mutation; D011487:Protein Conformation
chemical_list: D001897:Boronic Acids; D005456:Fluorescent Dyes; D037102:Lectins; D009004:Monosaccharide Transport Proteins; D005949:Glucose Oxidase; D005941:Glucokinase; D005947:Glucose