title: [A study of human papillomavirus infection during pregnancy and transmission of virus to fetus].
abstract: To study the human papillomavirus (HPV) infection during pregnancy and transmission of virus to fetus, samples such as, cervical secretion, peripheral blood, amniotic fluid, neonatal umbilical blood from 96 women with normal pregnancy were screened for HPV DNA by polymerase chain reaction (PCR), and HPV DNA in condyloma acuminata tissues, amniotic fluid of 31 pregnant women were detected by PCR as well. The results showed HPV DNA positive rate of condyloma acuminata tissues was 92.32%, of cervical secretion in normal pregnant group, was 35.71%, of peripheral blood was 57.69%. The HPV DNA maternal-fetus transmission rate was 44.44%, the transmission rate via placenta was 60%. It is concluded that HPV DNA can be found not only in condyloma acuminata tissues, but also in genital tract, peripheral blood of pregnant women, Besides the transmission route of genital tract, there is also the blood-placenta route.
authors.affiliation: The Second Affiliated Hospital, Tong Ji Medical University, Wuhan 430030.
authors.forename: D
authors.initials: D
authors.lastname: Deng
authors.forename: L
authors.initials: L
authors.lastname: Wen
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Zeng
authors.forename: X
authors.initials: X
authors.lastname: Ling
mesh_terms: D000328:Adult; D052685:Alphapapillomavirus / Q000235:genetics / Q000302:isolation & purification*; D000653:Amniotic Fluid / Q000821:virology; D003218:Condylomata Acuminata / Q000821:virology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D030361:Papillomavirus Infections / Q000635:transmission* / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D055815:Young Adult