Effects of baicalein on beta-amyloid peptide-(25-35)-induced amnesia in mice.
Baicalein may act on the benzodiazepine binding sites to exert an anxiolytic-like effect in mice. Since many benzodiazepine drugs have amnesic side-effect and baicalein can protect cultured cortical neurons from beta-amyloid peptide-(25-35)-induced toxicity, this study examined the amnesic effect of baicalein and its effects on beta-amyloid peptide-(25-35) (3 nmol/mouse, i.c.v.)-induced amnesia in mice. Using the step-through passive avoidance test, the results showed that baicalein (10-100 mg/kg, i.p.), unlike the benzodiazepine drug chlordiazepoxide (10 mg/kg, i.p.), had no significant amnesic effect. Baicalein (10-50 mg/kg, i.p.) also had no facilitating effect on the learning and memory. However, one dosage pretreatment, but not post-treatment, of baicalein (5 or 10 mg/kg, i.p.) attenuated beta-amyloid peptide-(25-35)-induced amnesia. Interestingly, post-treatment for 7 or 13 days of baicalein (10-15 mg/kg/day, i.p.), like melatonin (10 mg/kg/day, i.p.), also attenuated beta-amyloid peptide-(25-35)-induced amnesia. Therefore, this study demonstrated that baicalein has protective effect on beta-amyloid peptide-(25-35)-induced amnesia.
Wang
Sheng-Yun
SY
Department and Institute of Pharmacology, School of Medicine, National Yang-Ming University, No.155, Sec. 2, Li-Nong Street, Pei-tou Dist. (112), Taipei, Taiwan, Republic of China.
Wang
Hui-Hung
HH
Chi
Chin-Wen
CW
Chen
Chieh-Fu
CF
Liao
Jyh-Fei
JF
D000647:Amnesia / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control; D016229:Amyloid beta-Peptides / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects*; D002707:Chlordiazepoxide / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D044950:Flavanones / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D010446:Peptide Fragments / Q000008:administration & dosage / Q000633:toxicity; D012601:Scopolamine / Q000008:administration & dosage / Q000633:toxicity; D013997:Time Factors
D016229:Amyloid beta-Peptides; D014151:Anti-Anxiety Agents; D044950:Flavanones; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35); C006680:baicalein; D002707:Chlordiazepoxide; D012601:Scopolamine; D008550:Melatonin