title: Gender-specific association of a perilipin gene haplotype with obesity risk in a white population.
abstract: OBJECTIVE
  Perilipin is a class of protein-coating lipid droplets in adipocytes and steroidogenic cells. Our purpose was to examine the association between common single-nucleotide polymorphisms (SNPs) at the perilipin (PLIN) locus and obesity, as well as related phenotypes, in unrelated American adults.
  
  
  METHODS
  Four PLIN SNPs (PLIN 6209T>C, 11482G>A, 13041A>G, and 14995A>T) were typed in 734 white subjects (373 men and 361 women) attending a residential lifestyle intervention program. The baseline anthropometric and biochemical measures were used. Obesity was defined as BMI > or = 30 kg/m(2).
  
  
  RESULTS
  Multivariate analysis demonstrated that, in women, two of the SNPs (13041A>G, and 14995A>T) were significantly associated with percentage body fat (p = 0.016 for 13041A>G and p = 0.010 for 14995A>T) and waist circumference (p = 0.020 for 13041A>G and p = 0.045 for 14995A>T). Moreover, haplotype analysis using these two SNPs indicated that haplotypes A/T and G/T were both associated with significantly increased obesity risk (odds ratio = 1.76, 95% confidence interval 1.07 to 2.90 for haplotype A/T, and odds ratio = 1.73, 95% confidence interval 1.06 to 2.82 for haplotype G/T) when compared with haplotype A/A. No significant associations between PLIN variations and obesity were found in men.
  
  
  CONCLUSIONS
  Our data support the hypothesis that the PLIN locus may be a significant genetic determinant for obesity risk in whites and that women are more sensitive to the genetic effects of perilipin than men.
authors.affiliation: Nutrition and Genomics Laboratories, Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.forename: Haiqing
authors.initials: H
authors.lastname: Shen
authors.forename: Ilona
authors.initials: I
authors.lastname: Larson
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Schaefer
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Greenberg
authors.forename: David A
authors.initials: DA
authors.lastname: Tregouet
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella
authors.forename: Jose M
authors.initials: JM
authors.lastname: Ordovas
mesh_terms: D000273:Adipose Tissue; D000704:Analysis of Variance; D001823:Body Composition / Q000235:genetics; D015992:Body Mass Index; D002352:Carrier Proteins; D004247:DNA / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D000070778:Perilipin-1; D010750:Phosphoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012727:Sex Characteristics; D049629:Waist-Hip Ratio; D044465:White People
chemical_list: D002352:Carrier Proteins; D000070778:Perilipin-1; D010750:Phosphoproteins; D004247:DNA