Synthesis and antibacterial activity of new poly-S-lysine-porphyrin conjugates.
Studies on the synthesis, structural elucidation, and biological evaluation of new conjugates of poly-S-lysine with meso-substituted porphyrins are described. The new conjugates were used in the photoinactivation of antibiotic-resistant Gram-positive bacteria (Staphylococcus aureus strains ATCC 25923 and MRSA 110) and Gram-negative bacteria (Escherichia coli strain O4). The results show that the cationic conjugates are able to photosensitize the efficient inactivation of both types of bacteria.
Tomé
João P C
JP
Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Neves
Maria G P M S
MG
Tomé
Augusto C
AC
Cavaleiro
José A S
JA
Soncin
Marina
M
Magaraggia
Michela
M
Ferro
Stefania
S
Jori
Giulio
G
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008027:Light; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011107:Polylysine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013997:Time Factors
D000900:Anti-Bacterial Agents; D017319:Photosensitizing Agents; D011166:Porphyrins; D011107:Polylysine