title: Synthesis and antiviral activity against Coxsackie virus B3 of some novel benzimidazole derivatives.
abstract: Some benzimidazole derivatives were synthesized and evaluated for their antiviral properties. Compounds 20 and 21 showed potent selective activity against Coxsackie virus B(3) in VERO cells. Some structure-activity relationships were discussed.
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Cheng
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Xie
authors.forename: Xianjin
authors.initials: X
authors.lastname: Luo
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D029822:Enterovirus B, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles