title: Hyperuricemia in kidney transplantation.
abstract: Hyperuricemia is a common problem among renal transplant recipients. Its prevalence is clearly attributable to cyclosporine (CsA) use, although individual patients may have other risk factors as well. CsA lowers the urinary clearance of uric acid. The specific mechanism for this is unknown, but may involve alteration in tubular transport. Hyperuricemia may add on to several other factors in contributing to progressive deterioration of graft function and ultimately graft loss. The therapy of hyperuricemia may be particularly challenging in transplant patients.
authors.affiliation: Department of Medicine and Transplantation, Ospedali Riuniti di Bergamo, Mario Negri Institute for Pharmacological Research, Bergamo, Italy.
authors.forename: Norberto
authors.initials: N
authors.lastname: Perico
authors.forename: Igor
authors.initials: I
authors.lastname: Codreanu
authors.forename: Mariarosa
authors.initials: M
authors.lastname: Caruso
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Remuzzi
mesh_terms: D002908:Chronic Disease; D016572:Cyclosporine / Q000009:adverse effects; D006084:Graft Rejection; D006801:Humans; D033461:Hyperuricemia / Q000209:etiology*; D016030:Kidney Transplantation / Q000009:adverse effects*
chemical_list: D016572:Cyclosporine