Exploiting dendritic cells for active immunotherapy of cancer and chronic infection.
Dendritic cells (DC) are important antigen-presenting cells (APC) that can prime naive T-cells and control lymphocyte-mediated adaptive immune responses with respect to magnitude, memory, and self-tolerance. Understanding the biology of these cells is central to the development of new generation immunotherapies for cancer and chronic infection. This chapter presents a brief overview of DC biology and the preparation and use of DC-based vaccines.
O'Neill
David
D
Tumor Vaccine Center, NYU Cancer Institute, New York University School of Medicine, New York, NY, USA.
Bhardwaj
Nina
N
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods*; D007239:Infections / Q000276:immunology* / Q000628:therapy*; D008213:Lymphocyte Activation / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*