title: Autoimmune hemolytic anemia with giant cell hepatitis: case report and review of the literature.
abstract: Autoimmune hemolytic anemia (AIHA) with giant cell hepatitis (GCH) is an uncommon disease in children and is associated with an aggressive and often fatal course. The authors describe a 4-month-old girl who presented with AIHA and elevated liver enzymes. A liver biopsy was consistent with GCH. She was successfully treated with anti-CD20 antibody (rituximab)-containing therapy after failing initial immune suppression therapy. The authors also review the literature for similar cases.
authors.affiliation: Department of Pediatric Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Gorelik
authors.forename: Robert
authors.initials: R
authors.lastname: Debski
authors.forename: Haydar
authors.initials: H
authors.lastname: Frangoul
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy* / Q000473:pathology*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D015726:Giant Cells; D006505:Hepatitis / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007223:Infant; D000069283:Rituximab; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab