Dichloromethane activation. Direct methylenation of ketones and aldehydes with CH2Cl2 promoted by Mg/TiCl4/THF.
[reaction: see text] This Mg-TiCl4-promoted CH2-transfer reaction of CH2Cl2 represents an extremely simple, practical, and efficient methylenation of a variety of ketones and aldehydes, especially in enolizable or sterically hindered ketones such as 2,2-dimethylcyclohexanone, camphor, and fenchone.
Yan
Tu-Hsin
TH
Department of Chemistry, National Chung-Hsing University, Taichung 400, Taiwan, Republic of China. thyan@mail.nchu.edu.tw
Tsai
Chia-Chung
CC
Chien
Ching-Ting
CT
Cho
Chia-Ching
CC
Huang
Pei-Chen
PC