Lack of association between oxidized LDL-cholesterol concentrations and haptoglobin phenotypes in healthy subjects.
BACKGROUND
The haptoglobin (Hp) 2-2 phenotype has been known to have less antioxidative activity than Hp 1-1 and Hp 2-1. However, few have reported the relationship between oxidative stress and Hp phenotypes by using oxidized LDL. The relationship between Hp phenotypes and oxidative stress was therefore investigated in healthy adults.


METHODS
The serum Hp concentrations, albumin, uric acid, iron, L-ascorbic acid, total antioxidant status and oxidized LDL concentrations were measured and analysed in 200 healthy Korean men and women with Hp 2-1 and Hp 2-2 phenotypes.


RESULTS
The serum concentrations of Hp were significantly higher in the Hp 2-1 compared with the Hp 2-2 phenotype. However, serum concentrations of total antioxidant status and oxidized LDL did not show any statistical differences in either sex. The L-ascorbic acid concentrations in serum showed lower values in the Hp 2-2 compared with the Hp 2-1 phenotype, for both sexes (P < 0.05).


CONCLUSIONS
The concentration of L-ascorbic acid, the first line antioxidant, was lower in the Hp 2-2 than in the Hp 2-1 phenotype; this did not significantly affect the total antioxidant status, and there was no significant difference in oxidized LDL for either group in healthy adults.
Lee
Yong-Wha
YW
Department of Laboratory Medicine, Asan Medical Center and University of Ulsan, College of Medicine, 388-1 Pungnap-dong, Songpa-Gu, Seoul, 138-736 South Korea.
Min
Won-Ki
WK
Chun
Sail
S
Lee
Woochang
W
Park
Hyosoon
H
Lee
You Kyoung
YK
Lee
Do Hoon
DH
Son
Ji Eun
JE
D000418:Albumins / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood; D005260:Female; D006242:Haptoglobins / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D018384:Oxidative Stress; D010641:Phenotype; D014527:Uric Acid / Q000097:blood
D000418:Albumins; D000975:Antioxidants; D006242:Haptoglobins; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D014527:Uric Acid; D007501:Iron; D001205:Ascorbic Acid