title: PET-CT imaging of combined brachial and lumbosacral neurolymphomatosis.
abstract: Neurolymphomatosis is a rare manifestation of progressive non-Hodgkin's lymphoma. A 44-yr-old man with diffuse large B-cell lymphoma presented with unilateral progressive peripheral sensorimotor neuropathy after the 7th cycle of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) therapy. No pathology in the nervous system was evident by computerized tomography (CT), magnetic resonance imaging (MRI) of the head, spinal axis and plexuses and by repeated analysis of cerebrospinal fluid. However, the hybrid modality of positron emission tomography (PET) of fluorinated deoxyglucose (FDG) combined with CT scan (PET-CT) showed unilateral involvement of both the brachial and lumbosacral nervous plexuses. A complete recovery of neurological manifestations and normalization of PET-CT followed intensive chemotherapy with autologous stem cell transplantation. The diagnosis and localization of neurolymphomatosis may be supported by PET-CT imaging.
authors.affiliation: Department of Internal medicine B, Rabin Medical Center, Golda- Hasharon Campus, Petah-Tikva, Israel.
authors.forename: Pazit
authors.initials: P
authors.lastname: Kanter
authors.forename: Aliza
authors.initials: A
authors.lastname: Zeidman
authors.forename: Jonathan
authors.initials: J
authors.lastname: Streifler
authors.forename: Victor
authors.initials: V
authors.lastname: Marmelstein
authors.forename: Einat
authors.initials: E
authors.lastname: Even-Sapir
authors.forename: Ur
authors.initials: U
authors.lastname: Metser
authors.forename: Gideon Y
authors.initials: GY
authors.lastname: Stein
authors.forename: Amos M
authors.initials: AM
authors.lastname: Cohen
mesh_terms: D000328:Adult; D001917:Brachial Plexus; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008160:Lumbosacral Plexus; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000000981:diagnostic imaging* / Q000628:therapy; D008297:Male; D010524:Peripheral Nervous System Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18