Drastically lowering the titer of waterborne bacteriophage PRD1 by exposure to immobilized hydrophobic polycations.
Decrease in the titer of bacteriophage PRD1 (a model of animal adenoviruses) in aqueous solutions caused by the presence of systematically chemically derivatized surfaces was kinetically investigated. The greatest loss of infectivity--up to a 4-log reduction in the titer--was observed with immobilized hydrophobic polyethylenimine-based and dendrimer-based polycations.
Gelman
Faina
F
Department of Chemistry and Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Lewis
Kim
K
Klibanov
Alexander M
AM
D000327:Adsorption; D025622:Bacteriophage PRD1 / Q000187:drug effects* / Q000254:growth & development*; D002452:Cell Count; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D057927:Hydrophobic and Hydrophilic Interactions; D011073:Polyamines / Q000494:pharmacology*; D000071228:Polyelectrolytes; D011094:Polyethyleneimine / Q000494:pharmacology*; D014871:Water Microbiology; D014876:Water Pollution / Q000517:prevention & control; D018508:Water Purification / Q000379:methods*
D011073:Polyamines; D000071228:Polyelectrolytes; D011094:Polyethyleneimine