title: Correlation between antemortem magnetic resonance imaging findings and pathologically confirmed corticobasal degeneration.
abstract: BACKGROUND
  Slowly progressive asymmetric parkinsonism and cortical dysfunction clinically characterize corticobasal syndrome (CBS). Various pathologic findings, including corticobasal degeneration (CBD), progressive supranuclear palsy, and frontotemporal degenerations, underlie CBS.
  
  
  OBJECTIVE
  To determine if regional cortical and corpus callosum atrophy and subcortical and periventricular white matter (SPWM) signal changes on head magnetic resonance imaging were specific to CBD.
  
  
  METHODS
  Historical review of autopsy cases.
  
  
  METHODS
  Subspecialized behavioral neurology and movement disorder clinics within a neurology department of a tertiary referral center.
  
  
  METHODS
  Seventeen patients with CBS who had an autopsy-confirmed diagnosis of CBD or another neurodegenerative disease.
  
  
  METHODS
  Regional cerebral cortical atrophy, regional corpus callosum atrophy, and SPWM signal changes.
  
  
  RESULTS
  Similar patterns of regional atrophy and SPWM signal changes were found in the patients with autopsy-proven CBD and in the patients with other neurodegenerative diseases.
  
  
  CONCLUSIONS
  Neither cortical nor corpus callosum atrophy nor SPWM signal changes on head magnetic resonance imaging are specific to CBD.
authors.affiliation: Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. josephs.keith@mayo.edu
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
authors.forename: David F
authors.initials: DF
authors.lastname: Tang-Wai
authors.forename: Steven D
authors.initials: SD
authors.lastname: Edland
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Dickson
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Parisi
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
authors.forename: Bradley F
authors.initials: BF
authors.lastname: Boeve
mesh_terms: D000368:Aged; D001284:Atrophy / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000473:pathology*; D018709:Statistics, Nonparametric