[Subchronic toxicity test of transgenic rice].
OBJECTIVE
To observe the subchronic toxic effects of transgenic rice on rats.


METHODS
Based on gender and weight, 144 Wistar rats were randomly divided into three groups: transgenic rice group, nontransgenic rice group and AIN93G normal control group. They were fed for 90 days. Rats in transgenic rice group were fed with 73.2% transgenic rice. Rats in non-transgenic rice group were fed with 73.7% non-transgenic rice. Indicators were the following: body weight, body length, blood routine test, blood biochemistry test, organ weight, bone density and organ pathological examination.


RESULTS
Compared with non-transgenic rice group, glucose was lower while cholesterol and HDLD concentration were higher in transgenic rice group in mid-experiment. But all these differences disappeared at the end of experiment. ALT activity in transgenic rice were higher than that in non-transgenic rice group. Compared with AIN93G normal control group, body weight, TG, HDLD were higher and glucose was lower in transgenic rice group in mid-experiment and all these differences disappeared at the end of the experiment. No abnormality was found with the pathological examination on brain, heart, spleen, lung, kidney, stomach, duodenum, adrenal gland, spermary and ovary.


CONCLUSIONS
There were not enough evidences to confirm that transgenic rice had adverse effects on the rat.
Li
Yinghua
Y
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Piao
Jianhua
J
Zhuo
Qin
Q
Chen
Xiaoping
X
Chen
Xiaobin
X
Yang
Xiaoguang
X
D000818:Animals; D005260:Female; D008297:Male; D012275:Oryza / Q000235:genetics / Q000633:toxicity*; D010940:Plant Proteins / Q000235:genetics*; D030821:Plants, Genetically Modified / Q000633:toxicity*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D036401:Toxicity Tests, Chronic
D010940:Plant Proteins; C097148:Xa21 protein, Oryza sativa; D017346:Protein Serine-Threonine Kinases