title: Intracranial arterial dolichoectasia is associated with enlarged descending thoracic aorta.
abstract: BACKGROUND
  Intracranial arterial dolichoectasia (IADE) is defined as an increase in length and diameter of the intracranial arteries and is present in 12% of stroke patients. The pathophysiology is unknown; some data suggest that IADE is not merely a complication of atherosclerosis, but a distinct arteriopathy characterized by loss of elastic tissue in the media.
  
  
  OBJECTIVE
  To investigate the relationship between IADE and transesophageal echocardiography (TEE) variables such as ascending and descending thoracic aorta diameters.
  
  
  METHODS
  The sample included 154 patients with brain infarction (BI) and with measurement of the descending thoracic aorta on TEE. IADE was diagnosed by consensus between two neurologists. Information on demographic characteristics and risk factors was collected using a structured questionnaire, and a carotid ultrasound scan was performed.
  
  
  RESULTS
  IADE was identified in 23 of the 154 stroke patients (15%). The mean diameter (+/-SD) of the descending thoracic aorta was significantly higher in the IADE(+) than in the 131 IADE(-) stroke patients (mean +/- SD 26.6 +/- 3.6 vs 24.8 +/- 2.7 mm). The proportion of IADE increased regularly with the quartiles of descending thoracic aorta diameter: 5%, 13%, 18%, and 24% (test of linear trend, p = 0.02). The adjusted OR (95% CI) of IADE associated with a 1 mm increase in descending thoracic aorta diameter was 1.22 (95% CI, 1.02 to 1.45).
  
  
  CONCLUSIONS
  Patients with intracranial arterial dolichoectasia (IADE) have larger descending thoracic aorta diameters than non-IADE patients, suggesting that the underlying process causing IADE also affects the descending thoracic aorta.
authors.affiliation: Department of Neurology, Mignot Versailles Hospital, Versailles, France.
authors.forename: F
authors.initials: F
authors.lastname: Pico
authors.forename: J
authors.initials: J
authors.lastname: Labreuche
authors.forename: A
authors.initials: A
authors.lastname: Cohen
authors.forename: P-J
authors.initials: PJ
authors.lastname: Touboul
authors.forename: P
authors.initials: P
authors.lastname: Amarenco
mesh_terms: D000368:Aged; D000886:Anthropometry; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000473:pathology*; D017545:Aortic Aneurysm, Thoracic / Q000453:epidemiology; D002539:Cerebral Arterial Diseases / Q000097:blood / Q000453:epidemiology*; D002544:Cerebral Infarction / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D015897:Comorbidity; D004108:Dilatation, Pathologic / Q000453:epidemiology; D004452:Echocardiography; D017548:Echocardiography, Transesophageal; D004547:Elastic Tissue / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D010297:Paris / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL