National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development.
The use of illicit and licit drugs during pregnancy is a major public health concern because of potential adverse effects on the fetus and the risk to maternal health. Because the placenta is the primary link between the mother and the conceptus and is essential for the growth and survival of the fetus, abnormalities in placental formation and function resulting from drug use could have a major influence on pregnancy outcome. At present, little information is available on the impact of abused drugs on placental biology alone or in combination with other "host" factors (eg, stress, infections). This prompted the National Institute on Drug Abuse (NIDA) to convene a meeting of experts in placental biology to review cutting-edge research with the mission to translate existing information to new clinical and research initiatives in the drug abuse field. This report summarizes the presentations and research recommendations resulting from the workshop discussions.
Thadani
Pushpa V
PV
Division of Neuroscience and Behavioral Research. National Institute on Drug Abuse (NIDA), National Institutes of Health, 6001 Executive Boulevard, Room 4282, MSC 9555, Bethesda, MD 20892-9555, USA. pt24e@nih.gov
Strauss
Jerome F
JF
Dey
Sudhansu K
SK
Anderson
Virginia M
VM
Audus
Kenneth L
KL
Coats
Karen S
KS
Cross
James C
JC
Erlebacher
Adrian
A
Ganapathy
Vadivel
V
Linzer
Daniel I
DI
Miller
Richard K
RK
Novak
Donald A
DA
Rapaka
Rao S
RS
Sadovsky
Yoel
Y
Salafia
Carolyn M
CM
Soares
Michael
M
Unadkat
Jashvant
J
D005260:Female; D005313:Fetal Death; D047109:Fetal Development / Q000187:drug effects*; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000209:etiology*; D011256:Pregnancy Outcome; D011257:Pregnancy Proteins / Q000378:metabolism*; D018566:Pregnancy, High-Risk; D018570:Risk Assessment; D019966:Substance-Related Disorders / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control*; D014481:United States
D011257:Pregnancy Proteins