title: Use of stable isotopic tracers in studies of whole body calcium metabolism.
abstract: Stable isotopic tracers of calcium have been used to characterize the absorption of dietary calcium and the subsequent distribution of this element through the body. For a group of 7 healthy children, ages 4-14, and 7 children with osteogenesis imperfecta (OI), types I, III and IV, ages 6-17, there were no detectable differences in the fractional absorption of dietary calcium, 0.29+/-0.11 and 0.28+/-0.16, respectively. The total exchangeable pool of calcium was found to be 161+/-52 mg/kg for the healthy children and 95+/-29 mg/kg for the 3 children with Type I OI, 250+/-75 mg/kg for the 3 children with Type III OI and 216 mg/kg for the child with Type IV OI.
authors.affiliation: Laboratory of Theoretical and Physical Biology and the Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Yergey
authors.forename: N E
authors.initials: NE
authors.lastname: Vieira
authors.forename: S A
authors.initials: SA
authors.lastname: Abrams
authors.forename: J
authors.initials: J
authors.lastname: Marini
authors.forename: R E
authors.initials: RE
authors.lastname: Goans
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D001846:Bone Development / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D002127:Calcium Isotopes / Q000378:metabolism / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D006130:Growth Disorders / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007275:Injections, Intravenous; D010013:Osteogenesis Imperfecta / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D012016:Reference Values; D013054:Spectrophotometry, Atomic
chemical_list: D002127:Calcium Isotopes; D002118:Calcium