title: Update on genome completion and annotations: Protein Information Resource.
abstract: The Protein Information Resource (PIR) recently joined the European Bioinformatics Institute (EBI) and Swiss Institute of Bioinformatics (SIB) to establish UniProt--the Universal Protein Resource--which now unifies the PIR, Swiss-Prot and TrEMBL databases. The PIRSF (SuperFamily) classification system is central to the PIR/UniProt functional annotation of proteins, providing classifications of whole proteins into a network structure to reflect their evolutionary relationships. Data integration and associative studies of protein family, function and structure are supported by the iProClass database, which offers value-added descriptions of all UniProt proteins with highly informative links to more than 50 other databases. The PIR system allows consistent, rich and accurate protein annotation for all investigators.
authors.affiliation: Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC, USA.
authors.forename: Cathy
authors.initials: C
authors.lastname: Wu
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Nebert
mesh_terms: D000818:Animals; D019295:Computational Biology; D030562:Databases, Protein; D015894:Genome, Human; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D011506:Proteins / Q000145:classification / Q000235:genetics
chemical_list: D011506:Proteins