title: [Expression of bax protein in the cartilage cells of epiphyseal plate].
abstract: OBJECTIVE
  This experiment was designed to investigate the expression of Bax in the chondrocytes of the epiphyseal plate cartilage.
  
  
  METHODS
  Immunocytochemistry ABC method was used to determine the distribution of Bax immunoreactivity in the epiphyseal plate cartilage of rats.
  
  
  RESULTS
  Bax immunoreactivity was non-uniformly distributed throughout the epiphyseal cartilage. There was no Bax expression in chondrocytes under the perichondrium. Bax expression was observed in the resting chondrocytes of epiphysis; it increased in the proliferative chondrocytes of epiphysis, and immunoreactivity was mainly in the cytoplasm of chondrocytes; Bax expression was maximal in the hypertrophic chondrocytes of epiphysis, and immunoreactivity was mainly in the cytoplasm and nuclei of chondrocytes.
  
  
  CONCLUSIONS
  These immunocytochemical data indicate that Bax may promote chondrocytes apoptosis of epiphysis through an accumulative increase in quantity.
authors.affiliation: Department of Experiment Technique of Chengdu Military College, The 3rd Military Medical University, Chengdu 610083, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.forename: Ruixiang
authors.initials: R
authors.lastname: Li
authors.forename: Huijun
authors.initials: H
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Gao
authors.forename: Shuxia
authors.initials: S
authors.lastname: Yang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000502:physiology; D019902:Chondrocytes / Q000378:metabolism*; D006132:Growth Plate / Q000378:metabolism*; D007150:Immunohistochemistry; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D051028:bcl-2-Associated X Protein
chemical_list: C494828:Bax protein, rat; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein