Long-term effects of green tea ingestion on atherosclerotic biological markers in smokers.
OBJECTIVE
Smoking is a risk factor for coronary artery disease and triggers vascular injury by platelet aggregation and induces atherosclerosis through induction of oxidative stress. Green tea is known to have antioxidant capacity and anti-platelet activity.


METHODS
Twenty adult male smokers ingested 600 mL of green tea for 4 weeks. Their lipid profile, C-reactive protein (CRP), total antioxidant capacity, oxidized LDL, soluble VCAM-1, soluble ICAM-1, and soluble P-selectin were measured at baseline and 2 and 4 weeks after green tea ingestion.


RESULTS
Plasma soluble P-selectin (sP-selectin) levels decreased significantly after 2 and 4 weeks of green tea ingestion compared with those before green tea ingestion (P < 0.001). Plasma concentrations of oxidized LDL decreased significantly after green tea ingestion (P < 0.05).


CONCLUSIONS
The results of this study suggest the effect of green tea on sP-selectin and oxidized LDL.
Lee
Woochang
W
Department of Laboratory Medicine, Asan Medical Center and University of Ulsan College of Medicine, Songpa-Gu, Seoul, South Korea.
Min
Won-Ki
WK
Chun
Sail
S
Lee
Yong-Wha
YW
Park
Hyosoon
H
Lee
Do Hoon
DH
Lee
You Kyoung
YK
Son
Ji Eun
JE
D000328:Adult; D001161:Arteriosclerosis / Q000378:metabolism*; D015415:Biomarkers; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D019007:P-Selectin / Q000097:blood; D012907:Smoking / Q000378:metabolism*; D013662:Tea / Q000378:metabolism*; D013997:Time Factors
D015415:Biomarkers; D008077:Lipoproteins, LDL; D019007:P-Selectin; D013662:Tea; C099252:oxidized low density lipoprotein