title: dfrA20, A novel trimethoprim resistance gene from Pasteurella multocida.
abstract: A novel trimethoprim resistance gene, designated dfrA20, was detected on the 11-kb plasmid pCCK154 from Pasteurella multocida. The dfrA20 gene codes for a dihydrofolate reductase of 169 amino acids. Sequence comparisons revealed that the DfrA20 protein differed distinctly from all dihydrofolate reductases known so far.
authors.affiliation: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft, Höltystr. 10, 31535 Neustadt-Mariensee, Germany.
authors.forename: Corinna
authors.initials: C
authors.lastname: Kehrenberg
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwarz
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D002417:Cattle; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D016979:Pasteurella multocida / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics*; D010802:Phylogeny; D010957:Plasmids; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry / Q000235:genetics*; D014295:Trimethoprim / Q000494:pharmacology; D014296:Trimethoprim Resistance / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase