title: Acremonium pyomyositis in a pediatric patient with acute leukemia.
abstract: Invasive Acremonium infection in humans is rare. We report a patient with leukemia who developed pyomyositis due to Acremonium species. Painful cutaneous nodules and severe myalgia were the first clinical manifestations during the neutropenic stage after chemotherapy. Magnetic resonance image (MRI) revealed multiple nodular lesions scattered along the intramuscular regions of the lower legs. Culture of an aspiration grew Acremonium species. Surgical drainage was performed. Although all antifungal agents tested showed no in vitro inhibitory activity, we successfully treated this patient with amphotericin B, granulocyte colony-stimulating factor (G-CSF), and surgical drainage.
authors.affiliation: Department of Pediatrics, Veterans General Hospital-Kaohsiung, Kaohsiung, Taiwan.
authors.forename: Yu-Hsiang
authors.initials: YH
authors.lastname: Chang
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Huang
authors.forename: Po-Ren
authors.initials: PR
authors.lastname: Hsueh
authors.forename: Cheng-Hsiang
authors.initials: CH
authors.lastname: Hsiao
authors.forename: Shinn-Forng
authors.initials: SF
authors.lastname: Peng
authors.forename: Rong-Sen
authors.initials: RS
authors.lastname: Yang
authors.forename: Kai-Hsin
authors.initials: KH
authors.lastname: Lin
mesh_terms: D000164:Acremonium; D000208:Acute Disease; D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D004322:Drainage; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000150:complications*; D009181:Mycoses / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D009503:Neutropenia / Q000150:complications; D009894:Opportunistic Infections
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D000666:Amphotericin B