Ruthenium- and enzyme-catalyzed dynamic kinetic asymmetric transformation of 1,4-diols: synthesis of gamma-hydroxy ketones.
Enzymatic kinetic resolution of unsymmetrical 1,4-diols in combination with a ruthenium-catalyzed hydrogen transfer process led to a dynamic kinetic asymmetric transformation (DYKAT) of the least hindered alcohol. Oxidation of the second hydroxy group takes place under the reaction conditions leading to the formation of gamma-acetoxy ketones in high enantiomeric purity.
Martín-Matute
Belén
B
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
Bäckvall
Jan-E
JE
D002384:Catalysis; D004798:Enzymes / Q000378:metabolism*; D007659:Ketones / Q000138:chemical synthesis*; D007700:Kinetics; D008958:Models, Molecular; D013057:Spectrum Analysis; D013237:Stereoisomerism
D004798:Enzymes; D007659:Ketones