title: A three-centre experience of orthotopic neobladder reconstruction after radical cystectomy: initial results.
abstract: OBJECTIVE
  To assess, in a retrospective three-centre series, the initial experience and results of patients undergoing radical cystectomy and orthotopic neobladder reconstruction.
  
  
  METHODS
  The medical records were retrospectively reviewed for 104 suitable consecutive patients undergoing radical cystectomy and orthotopic neobladder reconstruction between June 1994 and April 2003. The initial histology, operating times, transfusion rates, complications, mortality rates, continence rates, potency rates, and cancer control rates were recorded.
  
  
  RESULTS
  The median (range) follow-up was 48 (6-113) months; 90 patients had a reconstruction with a 'Studer' neobladder, 12 with a 'Hautmann W pouch' and two with a 'T pouch' ileal neobladder. There were 24 early complications, and in eight patients re-operation was required; there was one death after surgery. There were 14 late complications and 10 patients required re-operation. The daytime continence rate was 99% and the nocturnal continence rate 78%. Five patients required intermittent self-catheterization. Twenty-two patients died from local and/or distant recurrences, and four from other causes.
  
  
  CONCLUSIONS
  Orthotopic neobladder reconstruction provides excellent continence rates, and both acceptable complication and mortality rates. Suitable patients undergoing radical cystectomy should be offered orthotopic neobladder reconstruction.
authors.affiliation: Harold Hopkins Department of Urology, Royal Berkshire Hospital, Reading, UK. jpmeyer@doctors.org.uk
authors.forename: Jon-Paul
authors.initials: JP
authors.lastname: Meyer
authors.forename: Brent
authors.initials: B
authors.lastname: Drake
authors.forename: James
authors.initials: J
authors.lastname: Boorer
authors.forename: David
authors.initials: D
authors.lastname: Gillatt
authors.forename: Rajendra
authors.initials: R
authors.lastname: Persad
authors.forename: Derek
authors.initials: D
authors.lastname: Fawcett
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015653:Cystectomy / Q000379:methods*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011183:Postoperative Complications / Q000209:etiology; D012008:Recurrence; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000601:surgery*; D014547:Urinary Diversion / Q000379:methods*; D016476:Urinary Reservoirs, Continent