title: [Monocyte HLA-DR expression as predictors of clinical outcome for patients with sepsis].
abstract: It has been generally accepted that the frequency of the HLA-DR-antigen expression on monocytes reflects the individual's immune state; therefore it has been regarded as a key indicator of the immune status in SIRS (systemic inflammatory response syndrome)-sepsis. One of the diagnostic indices for the level of immunoparalysis, it characterizes CARS (compensatory anti-inflammatory response syndrome). Lately, it has been frequently reported that the frequency of HLA-DR-antigen expression on monocytes is abnormally reduced in those patients with SIRS-sepsis. Reports suggest that the prognosis is very poor in cases with long-term sharp declines in HLA-DR-antigen expression on monocytes.
authors.affiliation: Department of Emergency and Critical Care Medicine, Nihon University School of Medicine.
authors.forename: Shozo
authors.initials: S
authors.lastname: Yoshida
mesh_terms: D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D009000:Monocytes / Q000276:immunology*; D011379:Prognosis; D018805:Sepsis / Q000175:diagnosis*; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis*
chemical_list: D006684:HLA-DR Antigens