[Influence of new hybrid antioxidants ichphans on erythrocyte morphology].
Scanning electron microscopy was used to study the effects of the new generation of compounds ICHFANs, which have a combined antioxidant and acetylcholine esterase inhibitory effect on the surface architectonics of erythrocytes. The incorporation of each of the studied compounds with the positively charged quaternary ammonium in the erythrocyte membrane and their distribution in the itramembraneous space were accompanied by the formation of echinocytes, stomatocytes, and compensative effects on erythrocyte shape. The time-dependent morphological transformation of erythrocytes apparently is determined by changes in the distribution of the compounds between the outer and inner monolayers of the erythrocyte membrane. A difference in the morphological effects of compounds with different hydrophobic properties was revealed.
Parshina
E Iu
EIu
Gendel'
L Ia
LIa
Rubin
A B
AB
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D048430:Cell Shape / Q000187:drug effects*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000648:ultrastructure; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D010636:Phenols / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D000975:Antioxidants; D010636:Phenols; D000644:Quaternary Ammonium Compounds