title: Novel mutations of the CYP2A6 gene in a Thai population with lowered capacity of coumarin 7-hydroxylation.
abstract: We explored genetic polymorphisms in a Thai population which exhibited a low capacity to metabolize coumarin. The following two silent single nucleotide polymorphisms (SNPs) were found: 1) SNP, 020228Kiyotani001; GENE NAME, CYP2A6; ACCESSION NUMBER, NT_011139; LENGTH, 25 base; 5'-AAACTACCTGCAG/TCTGAACACAGAG-3'. 2) SNP, 020228Kiyotani002; GENE NAME, CYP2A6; ACCESSION NUMBER, NT_011139; LENGTH, 25 base; 5'-AATCCCCAGCAC/TTTCCTGAATGAG-3'. These two mutations (G144A and C1245T), which were located in exon 1 and exon 8 of the CYP2A6 gene, were found in two subjects among nine poor metabolizers for coumarin.
authors.affiliation: Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Kiyotani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujieda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Daigo
authors.forename: Soisungwan
authors.initials: S
authors.lastname: Satarug
authors.forename: Pailin
authors.initials: P
authors.lastname: Ujjin
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kamataki