title: [Epidemiology of 118 cases of multiple sclerosis after 15 years of follow-up on the reference center of Hospital da Restauração, Recife, Pernambuco, Brazil].
abstract: The prevalence of multiple sclerosis (MS) has a considerable variability all over the world. According to Kurtzke, South America is considered to have low prevalence (minor than 5 cases: 100000 habitants).
  
  
  OBJECTIVE
  To describe the MS epidemiology on a reference center, compared to eight Brazilian series.
  
  
  METHODS
  according to a descriptive, prospective, longitudinal, prevalence study, we analyzed data of 118 patients, who attended at the Reference Center for Attention to Patients with Demielinizating Diseases of Hospital da Restauração (CRAPPDD-HR)-Recife-Pernambuco, Brazil, from January 1987 to March 2002, to have MS diagnosed according to Poser criteria.
  
  
  RESULTS
  The patients were followed up by 1 to 15 years. Ninety five (80.5%) patients were in treatment with immune-modulators. The prevalence was 1,36:100000 habitants. We have identified: predominance of mulattoes (110,93.2%), 82 (82.2%) cases clinically defined, 15 (12.7%) cases laboratorial defined and 6 (5.1%) cases clinically probable; a number of maximum bouts equal to 46; more frequent mild EDSS for patients with 1 to 10 years of MS of remittent-recurrent (RR) form. Gender rate of 83 cases of RR form was equivalent to the general one, however on RR with secondary progressive form form, the rate was 2.5 times greater for females than for males, and on primary progressive form, 5.5 times greater for males.
  
  
  CONCLUSIONS
  Although some results of this research had been similar to that of eight studies used as standards for comparison, the differences will require new approaches.
authors.affiliation: Serviço de Neurologia, Centro de Referência para Atenção ao Paciente Portador de Doença Desmielizante, Hospital da Restauração, Recife, PE, Brazil. lucabrito@uol.com.br
authors.forename: Maria Lúcia Brito
authors.initials: ML
authors.lastname: Ferreira
authors.forename: Maria Iris Moraes
authors.initials: MI
authors.lastname: Machado
authors.forename: Maria Lúcia
authors.initials: ML
authors.lastname: Vilela
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Guedes
authors.forename: Luis
authors.initials: L
authors.lastname: Ataíde
authors.forename: Silvana
authors.initials: S
authors.lastname: Santos
authors.forename: Sílvia Gomes
authors.initials: SG
authors.lastname: Laurentino
mesh_terms: D000328:Adult; D017668:Age of Onset; D001938:Brazil / Q000453:epidemiology; D004196:Disease Outbreaks; D015981:Epidemiologic Factors; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000145:classification / Q000453:epidemiology*; D017678:Sex Distribution; D012737:Sex Factors