title: Follicular dendritic cell sarcoma of the pharyngeal region: histologic, cytologic, immunohistochemical, and ultrastructural study of three cases.
abstract: Follicular dendritic cell sarcoma is a tumor of recent description and characterization; it is often underdiagnosed because it is easily confused with other entities. Three cases of follicular dendritic cell sarcoma are described in the present article. The first occurred in the parapharyngeal space in a 29-year-old woman who developed multiple recurrences over the span of 10 years. The second was located in the left tonsil in a 48-year-old man, and the third case developed in the parapharyngeal space in a 26-year-old man. All cases were positive for CD21 and CD35 and ultrastructurally they displayed a morphologic spectrum. The first case featured spindle cells with interdigitated long cell processes joined by well-developed desmosomes. In the other two cases there were round to ovoid cells with interwoven processes connected by occasional desmosomes. Including these three cases, a total of 20 follicular dendritic cell sarcoma of the pharyngeal region have been reported to date. The clinical behavior of these tumors is similar to other low-grade sarcomas.
authors.affiliation: Departamento de Patología, Instituto Nacional de Cancerologiía, México, DF. hdominguezm@terra.com.mx
authors.forename: Hugo
authors.initials: H
authors.lastname: Domínguez-Malagón
authors.forename: Ana María
authors.initials: AM
authors.lastname: Cano-Valdez
authors.forename: Adalberto
authors.initials: A
authors.lastname: Mosqueda-Taylor
authors.forename: Ondrej
authors.initials: O
authors.lastname: Hes
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D020566:Dendritic Cells, Follicular / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D017463:Receptors, Complement 3b / Q000032:analysis; D017464:Receptors, Complement 3d / Q000032:analysis; D012509:Sarcoma / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D017463:Receptors, Complement 3b; D017464:Receptors, Complement 3d