Cytogenetics of a pediatric unclassified sex cord-stromal tumor of the testis: a case report.
Unclassified sex cord-stromal tumors account for a small proportion of pediatric testicular tumors and, while most are clinically benign, some have demonstrated malignant potential. Histological findings do not correlate well with clinical behavior and, while cytogenetics may aid in both diagnosis and predicting clinical behavior, these data on sex cord-stromal tumors are scarce. We describe an unclassified sex cord-stromal tumor occurring in the testis of a prepubertal male without evidence of metastasis that had a previously unreported 54,XY,+3,+7,+9,+12,+13,+18,+19,+20 karyotype.
Yang
David T
DT
Department of Pathology,University of Utah Health Sciences Center, Room A513, 50 North Medical Drive, Salt Lake City, UT 84132, USA. david.yang@hsc.utah.edu
Lowichik
Amy
A
Chen
Jige
J
Snow
Brent W
BW
Ulbright
Thomas M
TM
Chen
Zhong
Z
D002881:Chromosomes, Human, Pair 12; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D018312:Sex Cord-Gonadal Stromal Tumors / Q000235:genetics* / Q000473:pathology; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology; D014314:Trisomy