title: Landiolol attenuates acute hemodynamic responses but does not reduce seizure duration during maintenance electroconvulsive therapy.
abstract: Maintenance electroconvulsive therapy (mECT) is an outpatient procedure that requires further consideration in terms of management of ambulatory anesthesia. Although many adjunctive drugs for stabilizing hemodynamic changes during ECT have been reported, side-effects of these drugs may delay recovery and discharge from hospital. The effects of landiolol, a novel ultra-short-acting beta-adrenergic blocker, have been measured on seizure duration, hemodynamic changes, recovery from anesthesia, and cognitive function during mECT under propofol anesthesia. A total of 10 patients with depression in the remission phase, were studied in a randomized, double-blind, placebo-controlled, crossover manner. Administration of 0.1 mg/kg of landiolol immediately before anesthesia significantly blunted the increase in heart rate and blood pressure during convulsions compared with placebo; landiolol was not associated with excessive hypotension or bradycardia. Landiolol did not affect seizure duration, recovery from anesthesia, or cognitive function before or after ECT. These results suggest that landiolol can be used effectively and safely during mECT.
authors.affiliation: Department of Anesthesiology, Nippon Medical School, Tokyo, Japan. no1-saka@nms.ac.jp
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Ryo
authors.initials: R
authors.lastname: Ogawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Suzuki
authors.forename: Mahito
authors.initials: M
authors.lastname: Kimura
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Okubo
authors.forename: Testuo
authors.initials: T
authors.lastname: Fujiya
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000758:Anesthesia; D000762:Anesthesia Recovery Period; D018592:Cross-Over Studies; D003866:Depressive Disorder / Q000628:therapy; D004311:Double-Blind Method; D004565:Electroconvulsive Therapy / Q000009:adverse effects* / Q000523:psychology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000627:therapeutic use*; D011594:Psychometrics; D012640:Seizures / Q000503:physiopathology* / Q000523:psychology; D014508:Urea / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D009025:Morpholines; C077049:landiolol; D014508:Urea