title: MMP-3 and -8 expression is found in the condylar surface of temporomandibular joints with internal derangement.
abstract: BACKGROUND
  Internal derangement is one of the most common disorder of the temporomandibular joint (TMJ). The aim of this study was to investigate the associations of matrix metalloproteinase (MMP)-3 and -8 expression in articular condylar surface with different stages of TMJ internal derangement according to Wilkes (Minn Med, 1978; 61: 645-52) and osteoarthrosis (OA) according to Dijkgraaf et al. (J Oral Maxillofac Surg, 1995; 53: 1182-92).
  
  
  METHODS
  The study was based on 54 condylar specimens obtained during TMJ surgery. Immunohistochemistry using antibodies specific to MMP-3 and -8, represented in cartilage destruction, was carried out.
  
  
  RESULTS
  In all tissue specimens, MMP-3 expression was intense in the surface layer but showed less intensive staining in the deeper layers. Some MMP-8 expression was also seen. The severity of TMJ internal derangement, however, did not seem to have a statistically significant correlation (P<0.05) with the expression of these enzymes.
  
  
  CONCLUSIONS
  The study confirms that distinct expression of MMP-3 and -8 is found in the condylar surface of TMJs with internal derangement.
authors.affiliation: Department of Prosthetic Dentistry and Stomatognathic Physiology, Institute of Dentistry, University of Oulu and Oulu University Hospital, Finland. petri.tiilikainen@oulu.fi
authors.forename: P
authors.initials: P
authors.lastname: Tiilikainen
authors.forename: P
authors.initials: P
authors.lastname: Pirttiniemi
authors.forename: T
authors.initials: T
authors.lastname: Kainulainen
authors.forename: H
authors.initials: H
authors.lastname: Pernu
authors.forename: A
authors.initials: A
authors.lastname: Raustia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008335:Mandibular Condyle / Q000378:metabolism*; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism*; D020784:Matrix Metalloproteinase 8 / Q000378:metabolism*; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism; D013704:Temporomandibular Joint / Q000378:metabolism* / Q000601:surgery; D013705:Temporomandibular Joint Disorders / Q000378:metabolism* / Q000601:surgery
chemical_list: D019278:Matrix Metalloproteinase 3; D020784:Matrix Metalloproteinase 8