Fetal warfarin syndrome.
Fetal warfarin syndrome (FWS) or warfarin (coumadin) embryopathy is a rare condition as a result of fetal exposure to maternal ingestion of warfarin during pregnancy. A male infant, whose mother was treated with the anticoagulant (warfarin) because of a mechanical heart valve replacement after rheumatic heart disease, presented with signs of warfarin embryopathy. The facial dysmorphism included hypoplasia of nasal bridge, laryngomalacia, pectus carinatum, congenital heart defects (atrial septal defect and patent ductus arteriosus), ventriculomegaly, stippled epiphyses, telebrachydactyly, and growth retardation. The pathogenesis and management of FWS are discussed.
Hou
Jia-Woei
JW
Division of Medical Genetics, Department of Pediatrics, Chang Gung Children's Hospital, 5, Fushing Street, Gueishan Shiang, Taoyuan, Taiwan 333, ROC. houjw741@cgmh.org.tw
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000015:Abnormalities, Multiple / Q000139:chemically induced / Q000473:pathology; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D048788:Growth and Development / Q000187:drug effects*; D006330:Heart Defects, Congenital / Q000139:chemically induced; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D018811:Maternal Exposure; D009666:Nose / Q000002:abnormalities; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014859:Warfarin / Q000009:adverse effects* / Q000627:therapeutic use
D000925:Anticoagulants; D014859:Warfarin