[Electrochemical behavior of daunorubicin at Co/GC ion implantation modified electrode and the application of the electrode].
OBJECTIVE
To study the electrochemical behavior of daunorubicin at Co/GC ion implantation modified electrode.


METHODS
With Co/GC ion implantation modified electrode as working electrode, daunorubicin was determined by voltammetry in 0.05 mol x L(-1) Na2HPO4-KH2PO4 (pH 6.82) solution.


RESULTS
A sensitive reductive peak of daunorubicin was obtained by linear sweep voltammetry. The peak potential was -0.60 V (vs SCE). The peak current was proportional to the concentration of daunorubicin over the range of 2.84 x 10(-8) - 1.42 x 10(-6) mol x L(-1) and 1.42 x 10(-6) - 1.28 x 10(-5) mol x L(-1) with the detection limit of 1.42 x 10(-8) mol x L(-1). The reduction wave was applied to the determination of daunorubicin. The electrochemical behavior and reaction mechanism were studied by linear sweep and cyclic voltammetry.


CONCLUSIONS
The reduction process was quasi-reversible with adsorption characteristics.
Wang
Jing
J
Department of Chemistry, Beijing Normal University, Beijing 100875, China.
Hu
Jing-bo
JB
Li
Qi-long
QL
D000903:Antibiotics, Antineoplastic / Q000032:analysis* / Q000737:chemistry; D002244:Carbon; D003035:Cobalt; D003630:Daunorubicin / Q000032:analysis* / Q000737:chemistry; D004563:Electrochemistry; D004566:Electrodes; D006863:Hydrogen-Ion Concentration
D000903:Antibiotics, Antineoplastic; D003035:Cobalt; D002244:Carbon; D003630:Daunorubicin