title: Comparison of pressurized solvent and reflux extraction methods for the determination of perfluorooctanoic acid in polytetrafluoroethylene polymers using LC-MS-MS.
abstract: Both pressurized solvent extraction (PSE) and reflux extraction in various solvents were used to select the most efficient system for the determination of the quantity of perfluorooctanoic acid (PFOA) present in polytetrafluoroethylene polymers. After evaporating the solvent, PFOA was determined using liquid chromatography tandem mass spectrometry. Ethanol, water and methanol gave comparable results and were shown to be good solvents for this extraction. Acetonitrile was a reasonable solvent using the reflux extraction method, but not with PSE. Chloroform resulted in poor recovery for both extraction methods. PSE proved to be the more efficient extraction method.
authors.affiliation: DuPont Corporate Center for Analytical Sciences, Experimental Station 402/5321, P.O. Box 80402, Wilmington, DE 19880-0402, USA.
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Larsen
authors.forename: Mary A
authors.initials: MA
authors.lastname: Kaiser
authors.forename: Miguel
authors.initials: M
authors.lastname: Botelho
authors.forename: Gilbert R
authors.initials: GR
authors.lastname: Wooler
authors.forename: L William
authors.initials: LW
authors.lastname: Buxton
mesh_terms: D002210:Caprylates / Q000032:analysis*; D002853:Chromatography, Liquid / Q000379:methods; D005466:Fluorocarbons / Q000032:analysis*; D011108:Polymers; D011138:Polytetrafluoroethylene / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D002210:Caprylates; D005466:Fluorocarbons; D011108:Polymers; D014874:Water Pollutants, Chemical; D011138:Polytetrafluoroethylene; C023036:perfluorooctanoic acid