Hydroamination/Heck reaction sequence for a highly regioselective one-pot synthesis of indoles using 2-chloroaniline.
A one-pot indole synthesis consisting of a highly regioselective TiCl(4)-catalyzed hydroamination and a 5-endo Heck cyclization starting from 2-chloroaniline is described, using an in-situ generated, sterically hindered imidazol-2-ylidene palladium complex.
Ackermann
Lutz
L
Department of Chemistry, Ludwig-Maximilians-Universität München, D-81377 München, Germany. lutz.ackermann@cup.uni-muenchen.de
Kaspar
Ludwig T
LT
Gschrei
Christian J
CJ