Helicobacter pylori and gastric autoimmunity.
Host specific T-cell response is critical for the outcome of Helicobacter pylori infection. In genetically susceptible individuals, H. pylori can activate gastric CD4+ Th1 cells that recognize cross-reactive epitopes shared by H. pylori proteins and self H+, K+-ATPase, leading to gastric autoimmunity via molecular mimicry.
D'Elios
Mario Milco
MM
Department of Internal Medicine, University of Florence, Viale Morgagni, 85-50134 Florence, Italy. delios@unifi.it
Bergman
Mathijs P
MP
Amedei
Amedeo
A
Appelmelk
Ben J
BJ
Del Prete
Gianfranco
G
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D005756:Gastritis / Q000201:enzymology / Q000276:immunology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans
D000942:Antigens, Bacterial; D001324:Autoantigens