Neuronal outgrowth of PC-12 cells after combined treatment with nerve growth factor and a magnetic field: influence of the induced electric field strength.
In view of possible therapeutic applications of magnetic fields, the effect of an enhancement of neuronal outgrowth at higher figures of flux density and induced field strength was investigated. On the average sinusoidal magnetic field treatment at 100 microTrms/50 Hz did not change nerve growth factor (NGF) induced neurite outgrowth to a statistically significant extent. These results suggest that further increasing the induced field strength by using either higher flux densities and/or more sophisticated wave forms might be necessary to cause the neuronal response of PC-12 cells, as seen in other experiments.
Schimmelpfeng
J
J
Research Centre Karlsruhe, Institute for Medical Engineering and Biophysics, Karlsruhe, Germany. schimmelpfeng@imb.fzk.de
Weibezahn
K-F
KF
Dertinger
H
H
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000528:radiation effects; D049108:Cell Enlargement / Q000187:drug effects / Q000528:radiation effects; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004361:Drug Tolerance / Q000528:radiation effects; D004574:Electromagnetic Fields; D020932:Nerve Growth Factor / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects* / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D011829:Radiation Dosage; D051381:Rats
D020932:Nerve Growth Factor