title: Identification of 7-phenylaminothieno- [3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors.
abstract: We disclose here a new class of kinase inhibitors, obtained by replacing the phenyl ring of a 3-quinolinecarbonitrile system with a thiophene ring. When suitably substituted, the resultant 7-phenylaminothieno[3,2-b]pyridine-6-carbonitrile analogues show potent inhibition of Src kinase activity.
authors.affiliation: Chemical and Screening Sciences and Oncology, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. bosched@wyeth.com
authors.forename: Diane H
authors.initials: DH
authors.lastname: Boschelli
authors.forename: Biqi
authors.initials: B
authors.lastname: Wu
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Barrios Sosa
authors.forename: Haris
authors.initials: H
authors.lastname: Durutlic
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
authors.forename: Yuri
authors.initials: Y
authors.lastname: Raifeld
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Golas
authors.forename: Frank
authors.initials: F
authors.lastname: Boschelli
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology; D019061:src-Family Kinases / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D011725:Pyridines; D013876:Thiophenes; D019061:src-Family Kinases