Recognition and phagocytosis of multiple periodontopathogenic bacteria by anti-Porphyromonas gingivalis heat-shock protein 60 antisera.
The present study has been performed to evaluate Porphyromonas gingivalis heat shock protein (HSP) 60 as a candidate vaccine to protect against multiple putative periodontopathic bacteria. Mouse anti-P. gingivalis HSP antisera demonstrated the elevated IgG antibody titers against the multiple bacteria tested and cross-reacted with heat-induced bacterial proteins of the target bacteria. The antisera also demonstrated a significantly higher opsonophagocytosis function against all the target bacteria than the control sera (P<0.01). We concluded that P. gingivalis HSP 60 could potentially be developed as a vaccine against multiple periodontopathic bacteria.
Choi
J-I
JI
Department of Periodontology and Research Institute for Oral Biotechnology, School of Dentistry, Pusan National University, Pusan, Republic of Korea. jrapa@pusan.ac.kr
Choi
K-S
KS
Yi
N-N
NN
Kim
U-S
US
Choi
J-S
JS
Kim
S-J
SJ
D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology*; D015153:Blotting, Western; D018834:Chaperonin 60 / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D007106:Immune Sera / Q000276:immunology*; D051379:Mice; D010510:Periodontal Diseases / Q000382:microbiology / Q000517:prevention & control*; D016966:Porphyromonas gingivalis / Q000276:immunology*
D001428:Bacterial Vaccines; D018834:Chaperonin 60; D007106:Immune Sera