title: Constituents of red wine other than alcohol improve endothelial function in patients with coronary artery disease.
abstract: BACKGROUND
  Several studies suggest that red wine is beneficial in coronary artery disease (CAD). Although the long-term effect of moderate red wine consumption on endothelial function is currently under investigation, there is little knowledge about its effect on postprandial endothelial function and haemostatic factors. The aim of the present study was to investigate the postprandial effects of alcohol content and the antioxidants of red wine on endothelial function and fibrinogen levels in CAD patients.
  
  
  METHODS
  Fifteen males with angiographically documented CAD were recruited for the study. All volunteers ingested 250 ml of either red wine or de-alcoholized red wine on two different days. Blood samples (for analysis of fibrinogen and blood lipids) were collected and flow-mediated dilatation (FMD) was determined before and 30, 60 and 90 min following consumption of each beverage
  
  
  RESULTS
  FMD was higher following the consumption of de-alcoholized red wine [type of wine effect, P=0.05 repeated measures analysis of variance (ANOVA)]. Furthermore, the pattern of the response was different between the two beverages, as FMD increased following the ingestion of de-alcoholized red wine, but it decreased after consumption of regular red wine (type of wine by time interaction effect, P=0.006 repeated measures ANOVA). Fibrinogen concentrations were unaltered
  
  
  CONCLUSIONS
  Acute ingestion of red wine without alcohol led to higher FMD than ingestion of regular red wine in CAD patients. The acute effect of red wine on endothelial function may be different than its long-term effect and it could be attributed to its constituents other than alcohol.
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece. popikaratzi@yahoo.com
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Karatzi
authors.forename: Christos
authors.initials: C
authors.lastname: Papamichael
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Aznaouridis
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Karatzis
authors.forename: John
authors.initials: J
authors.lastname: Lekakis
authors.forename: Charis
authors.initials: C
authors.lastname: Matsouka
authors.forename: George
authors.initials: G
authors.lastname: Boskou
authors.forename: Antonia
authors.initials: A
authors.lastname: Chiou
authors.forename: Marietta
authors.initials: M
authors.lastname: Sitara
authors.forename: Giorgia
authors.initials: G
authors.lastname: Feliou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kontoyiannis
authors.forename: Antonis
authors.initials: A
authors.lastname: Zampelas
authors.forename: Myron
authors.initials: M
authors.lastname: Mavrikakis
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D003327:Coronary Disease / Q000097:blood / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D000431:Ethanol / Q000008:administration & dosage; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014920:Wine
chemical_list: D000975:Antioxidants; D008055:Lipids; D000431:Ethanol; D005340:Fibrinogen