Relative contributions of innate and acquired host responses to bacterial control and arthritis development in Lyme disease.
TLR2(-/-)/scid double-mutant mice were infected with B. burgdorferi to assess the relative importance of acquired and innate host defenses. Although spirochete levels at 4 weeks were lower in TLR2(-/-) mice than in TLR2(-/-)/scid mice, the increased arthritis severity of TLR2 (Toll-like receptor 2)-deficient mice was reduced by the presence of the scid mutation.
Wang
Xiaohui
X
Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132-2501, USA.
Ma
Ying
Y
Weis
John H
JH
Zachary
James F
JF
Kirschning
Carsten J
CJ
Weis
Janis J
JJ
D000818:Animals; D025065:Borrelia burgdorferi / Q000302:isolation & purification*; D007113:Immunity, Innate; D007596:Joints / Q000473:pathology; D008193:Lyme Disease / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D016513:Mice, SCID; D011956:Receptors, Cell Surface / Q000502:physiology*; D051195:Toll-Like Receptor 2
D011956:Receptors, Cell Surface; C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2