Integration from proteins to organs: the IUPS Physiome Project.
The IUPS Physiome Project is an internationally collaborative open source project intended to provide a public domain framework for computational physiology, including the development of modeling standards, computational tools and web-accessible databases of models of structure and function at all spatial scales and across all organ systems. Here, we illustrate the application of this multi-scale modeling approach to three organ systems: the heart, the lungs and the musculo-skeletal system, and in each case we show how the organ level models incorporate tissue and cell-level physiology. Although the computational physiology framework presented here does not yet incorporate models of ageing processes, the model-based approach is certainly capable of describing ageing and disease-related processes both via parameter changes within the models of normal physiological processes and via models of additional processes added to the framework.
Hunter
Peter
P
Bioengineering Institute, University of Auckland, 70 Symonds Street, Auckland, New Zealand. p.hunter@auckland.ac.nz
Smith
Nicolas
N
Fernandez
Justin
J
Tawhai
Merryn
M
D000818:Animals; D019295:Computational Biology; D003198:Computer Simulation; D016208:Databases, Factual; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology; D008954:Models, Biological; D009142:Musculoskeletal Physiological Phenomena; D009141:Musculoskeletal System / Q000033:anatomy & histology; D012984:Software; D018511:Systems Integration