title: Process technologies for purity enhancement of large discovery libraries.
abstract: The design, synthesis and characterization of structurally diverse compound libraries are key first steps in drug discovery. High-throughput screening of these libraries against protein targets is a useful procedure for identifying hits, which can then be optimized to produce compound leads against these protein targets. For this process to be most successful the initial compounds screened must be of high quality, necessitating high-throughput characterization and purification. This review summarizes recent advances in purification processes for combinatorial chemistry.
authors.affiliation: Johnson & Johnson Pharmaceutical Research & Development LLC Drug Discovery, Cranbury, NJ 08512, USA.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Pottorf
authors.forename: Mark R
authors.initials: MR
authors.lastname: Player
mesh_terms: D002845:Chromatography; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis / Q000302:isolation & purification*
chemical_list: D004364:Pharmaceutical Preparations