title: A particular hepatitis C virus protease NS3 gene pattern in a patient not responding to interferon-ribavirin therapy.
authors.affiliation: Département de Microbiologie (E.A. Biodiversity and Microbial Ecology no. 3882), Centre Hospitalier Universitaire Morvan, 2 avenue Foch, 29609 Brest Cedex, France. sophie.vallet@chu-brest.fr
authors.forename: S
authors.initials: S
authors.lastname: Vallet
authors.forename: J B
authors.initials: JB
authors.lastname: Nousbaum
authors.forename: S
authors.initials: S
authors.lastname: Gouriou
authors.forename: M C
authors.initials: MC
authors.lastname: Legrand-Quillien
authors.forename: A
authors.initials: A
authors.lastname: Goudeau
authors.forename: B
authors.initials: B
authors.lastname: Picard
mesh_terms: D001707:Biopsy, Needle; D004279:DNA, Viral / Q000032:analysis; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D016174:Hepacivirus / Q000235:genetics* / Q000302:isolation & purification; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007150:Immunohistochemistry; D016898:Interferon-alpha / Q000627:therapeutic use*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D012254:Ribavirin / Q000627:therapeutic use*; D012720:Severity of Illness Index; D017211:Treatment Failure; D019562:Viral Load; D017361:Viral Nonstructural Proteins / Q000235:genetics*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D004279:DNA, Viral; D016898:Interferon-alpha; D012254:Ribavirin; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases