title: Is previous aberrant reproductive outcome predictive of subsequently reduced fecundity?
abstract: BACKGROUND
  Effect of past reproductive performance on subsequent fecundity is uncertain.
  
  
  METHODS
  A total of 2983 consecutive pregnant women self-completed questionnaires about time to pregnancy (TTP), pregnancy planning, previous pregnancies, contraceptive use, age, and individual/lifestyle variables. Outcome measures were: TTP, conception rates (CR) and, subfecundity odds ratio (OR; with 95% confidence intervals) before and after each outcome of last pregnancy.
  
  
  RESULTS
  After miscarriage, TTP was longer than before miscarriage [2.1 (1.4-3.0), P < 0.001] and than TTP after livebirth [OR = 2.1 (1.6-2.6), P < 0.001]. Also subfecundity OR after miscarriage increased [1.7 (1.2-2.4), 1.8 (1.2-2.5), P = 0.001, 0.002 respectively]. This effect was more evident in older and obese women. Compared with livebirth, time to ectopic pregnancy (EP) was longer [OR = 13.8 (1.8-108.5), P = 0.001] but TTP after EP was not significantly different. Subfecundity OR relative to livebirth were 12.8 (3.6-45.0) (P<0.001) before, and 3.9 (1.4-11.0) (P=0.01) after, EP. The CR after EP increased 3-fold (1.1-8.3) over those prior to EP. Time to the terminated pregnancies even without contraceptive failures was shorter than that to livebirth [OR = 0.5 (0.3-0.7), P = 0.001] and than TTP after termination [0.35 (0.1-0.8), P = 0.001]. Also subfecundity OR increased after termination [7.2 (1.8-29.7), P = 0.02].
  
  
  CONCLUSIONS
  Miscarriers should be counselled about short-term reduction in subsequent fecundity, and earlier investigations should be considered in those who have other potential risk factors for reduced fertility. Further studies are required to clarify the relatively favourable effect on fecundity following EP and the relative reduction in fecundity after termination of pregnancy.
authors.affiliation: University of Hull Postgraduate Medical Institute, Hull and York Medical School, The Academic Department of Obstetrics and Gynaecology, Hull, UK. mamhassan@yahoo.com
authors.forename: M A M
authors.initials: MA
authors.lastname: Hassan
authors.forename: S R
authors.initials: SR
authors.lastname: Killick
mesh_terms: D000028:Abortion, Induced / Q000009:adverse effects*; D000022:Abortion, Spontaneous / Q000150:complications* / Q000503:physiopathology; D000375:Aging; D005260:Female; D005298:Fertility; D005306:Fertilization; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D011271:Pregnancy, Ectopic / Q000503:physiopathology*; D011379:Prognosis; D011795:Surveys and Questionnaires; D013997:Time Factors