title: Synthesis and binding affinity to human alpha and beta estrogen receptors of various 7-hydroxycoumarins substituted at 4- and 3,4- positions.
abstract: The study of the relative binding affinity (RBA) to the human alpha and beta estrogen receptors (ERs) of various 7-hydroxycoumarins substituted at 4- and 3,4- positions is weak and lacks in selectivity for both ERalpha and ERbeta. The 4-(4-hydroxyphenyl)-7-hydroxycoumarin shows a weak RBA to ERbeta and 3,4-diphenyl-7-hydroxycoumarin presents a stronger RBA to ERalpha than ERbeta.
authors.affiliation: Faculté de Pharmacie de Paris-Sud, Laboratoire de Chimie Thérapeutique, 5 rue Jean-Baptiste-Clément, 92296 Chatenay Malabry cedex, France. serge.kirkiacharian@cep.u-psud.fr
authors.forename: Serge
authors.initials: S
authors.lastname: Kirkiacharian
authors.forename: Anh Tuan
authors.initials: AT
authors.lastname: Lormier
authors.forename: Henri
authors.initials: H
authors.lastname: Chidiack
authors.forename: Françoise
authors.initials: F
authors.lastname: Bouchoux
authors.forename: Evelyne
authors.initials: E
authors.lastname: Cérède
mesh_terms: D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D047629:Estrogen Receptor beta / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding / Q000502:physiology; D014468:Umbelliferones / Q000138:chemical synthesis* / Q000378:metabolism*
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D014468:Umbelliferones