Prenylated flavonoids as tyrosinase inhibitors.
In order to find new tyrosinase inhibitors and the effects of prenyl residue on flavonoid molecules, eight prenylated and three synthetic vinylated flavonoids were examined on their inhibitory effect against tyrosinase activity. From the results, kuwanon C, papyriflavonol A, sanggenon D and sophoflavescenol were found to possess the considerable inhibitory activity. Especially, sanggenon D is revealed as a potent inhibitor (IC50 = 7.3 microM), compared to the reference compound, kojic acid (IC50 = 24.8 microM). However, the prenylation with isoprenyl group or the vinylation to flavonoid molecules did not enhance tyrosinase inhibitory activity.
Lee
Nan Kyoung
NK
College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea.
Son
Kun Ho
KH
Chang
Hyeun Wook
HW
Kang
Sam Sik
SS
Park
Haeil
H
Heo
Moon Young
MY
Kim
Hyun Pyo
HP
D000363:Agaricales / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D029586:Moraceae / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D017368:Protein Prenylation
D005419:Flavonoids; D010455:Peptides; D010936:Plant Extracts; C117237:sophoflavescenol; D014442:Monophenol Monooxygenase