Expression of nuclear receptor coregulators in ovarian stromal and epithelial tumours.
Granulosa cell tumours of the ovary (GCT) exhibit high expression of estrogen receptor beta (ERbeta). A role for estrogen receptors in these tumours may depend on altered co-activator expression. This study examines the expression of the co-activators SRC-1a/e, SRC-2, SRC-3, SRA, and the corepressors NCoR and SMRT in GCT, epithelial ovarian tumours and normal ovary. No significant difference in the expression of SRC-1, SRC-2, SRC-3 or NCoR and SMRT was found. In particular, there was no correlation of co-activator expression with ERbeta expression. There was a significant upregulation in the expression of the novel RNA co-activator SRA in the serous tumours compared with the other tumour types and normal ovary. The findings suggest that ERbeta may require co-activators, other than members of the SRC family for the modulation of transcription in GCT.
Hussein-Fikret
S
S
Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Vic. 3168, Australia; Monash University Department of Medicine, Monash Medical Centre, Clayton, Vic. 3168, Australia.
Fuller
P J
PJ
D000123:Acetyltransferases; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D018282:Cystadenocarcinoma, Mucinous / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D018284:Cystadenocarcinoma, Serous / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004268:DNA-Binding Proteins / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D047629:Estrogen Receptor beta / Q000378:metabolism*; D005260:Female; D006106:Granulosa Cell Tumor / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D051548:Histone Acetyltransferases; D006801:Humans; D007265:Inhibins / Q000097:blood; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D056971:Nuclear Receptor Co-Repressor 1; D056985:Nuclear Receptor Co-Repressor 2; D056920:Nuclear Receptor Coactivator 1; D051958:Nuclear Receptor Coactivator 2; D056921:Nuclear Receptor Coactivator 3; D015513:Oncogene Proteins; D010053:Ovary / Q000166:cytology / Q000378:metabolism*; D062085:RNA, Long Noncoding; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D017154:Stromal Cells / Q000166:cytology / Q000378:metabolism*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; C539127:NCOR1 protein, human; C539130:NCOR2 protein, human; D009687:Nuclear Proteins; D056971:Nuclear Receptor Co-Repressor 1; D056985:Nuclear Receptor Co-Repressor 2; D051958:Nuclear Receptor Coactivator 2; D015513:Oncogene Proteins; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D022661:RNA, Untranslated; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C405423:steroid receptor RNA activator; D007265:Inhibins; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; C538859:NCOA1 protein, human; C538866:NCOA3 protein, human; D056920:Nuclear Receptor Coactivator 1; D056921:Nuclear Receptor Coactivator 3