title: CYP3A4*18: it is not rare allele in Japanese population.
abstract: We sequenced all 13 exons of the CYP3A4 gene derived from 48 Japanese subjects. One subject possess the 20070 T>C mutation in the exon 10 (result in leu293Pro substitution, namely CYP3A4(*)18), as heterozygote. Thus, we investigated the frequency of CYP3A4(*)18 in 118 Japanese population using polymerase chain reaction-restriction fragment length polymorphism with Msp I and determined that the frequency of the CYP3A4(*)18 allele was 1.3%.
authors.affiliation: Department of Pharmacy, University of Tokyo Hospital, Japan.
authors.forename: Takehito
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Nobue
authors.initials: N
authors.lastname: Nagafuchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ozeki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kubota
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Seishi
authors.initials: S
authors.lastname: Ogawa
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yamada
authors.forename: Hisamaru
authors.initials: H
authors.lastname: Hirai
authors.forename: Tatsuji
authors.initials: T
authors.lastname: Iga