Monosomy 22 as a diagnostic aid in a case of late recurrence of adult granulosa cell tumor of the ovary.
Cytogenetic analysis of a case of metastatic granulosa cell tumor recurring 21 years after oophorectomy revealed monosomy 22. This anomaly, typical of granulosa cell tumor, coupled with the pathologic and immunophenotypic findings assisted in establishing the proper diagnosis of this lesion in the absence of the original histopathologic slides.
Caughron
Samuel K
SK
Department of Pathology, Creighton University Medical Center, 601 North 30th Street, Omaha, NE 68131, USA. caughron@creighton.edu
Bridge
Julia A
JA
Bewtra
Chhanda B
CB
Hunter
William J
WJ
Nelson
Marilu
M
Soundararajan
Suganthi
S
Silva
Edibaldo
E
Gatalica
Zoran
Z
D000368:Aged; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006106:Granulosa Cell Tumor / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D009006:Monosomy; D010051:Ovarian Neoplasms / Q000235:genetics*; D012186:Retroperitoneal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000556:secondary*