title: Bullous pemphigoid associated with mantle cell lymphoma.
abstract: BACKGROUND
  Bullous pemphigoid has developed in association with different types of malignant diseases, including a few cases of B-cell lymphoproliferative disorders. However, the paraneoplastic significance of this association is still controversial.
  
  
  METHODS
  We describe a 39-year-old patient who presented with a bullous eruption and generalized lymphadenopathy. The results of histologic, immunofluorescence, and antigenic studies confirmed the diagnosis of bullous pemphigoid. The histopathologic and immunophenotypic features of a lymph node biopsy specimen were consistent with mantle cell lymphoma. There was total resolution of the mucocutaneous lesions when mantle cell lymphoma went into remission.
  
  
  CONCLUSIONS
  The age of the patient and the concomitant appearance and simultaneous remission of both diseases strongly suggest that bullous pemphigoid was a paraneoplastic phenomenon in the present case.
authors.affiliation: Departments of Dermatology and Pathology, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. piranzo@clinic.ub.es
authors.forename: Pilar
authors.initials: P
authors.lastname: Iranzo
authors.forename: Ingrid
authors.initials: I
authors.lastname: López
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Robles
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Mascaró
authors.forename: Elías
authors.initials: E
authors.lastname: Campo
authors.forename: Carmen
authors.initials: C
authors.lastname: Herrero
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D020522:Lymphoma, Mantle-Cell / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000473:pathology; D010391:Pemphigoid, Bullous / Q000209:etiology* / Q000473:pathology; D012074:Remission Induction