Polyomaviruses and cancer--interplay between viral proteins and signal transduction pathways.
Polyomaviruses are highly suspected to be involved in the development of cancer. A strong correlation has been established between the activity of an early viral genome and the development of a transformed phenotype. Polyomavirus transforming antigens (T-antigens) are the major suspects in the process of deregulating cellular equilibrium. Multiple interactions between T-antigens and cellular regulatory proteins have been detected at different regulatory levels including signal transduction, gene expression, cell cycle progression, and possible DNA repair. In this context, we are reviewing the most recent experimental evidence which, in combination with more than thirty years of studies of polyomaviruses, could help us understand whether and how viral infection contributes to the development of malignant transformation.
Wang
J Ying
JY
Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, PA 19122, USA.
Del Valle
L
L
Peruzzi
F
F
Trojanek
J
J
Giordano
A
A
Khalili
K
K
Reiss
K
K
D000818:Animals; D000957:Antigens, Viral, Tumor / Q000737:chemistry; D001665:Binding Sites; D001932:Brain Neoplasms / Q000821:virology; D002453:Cell Cycle; D003593:Cytoplasm / Q000378:metabolism; D004260:DNA Repair; D005786:Gene Expression Regulation; D016679:Genome, Viral; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D008954:Models, Biological; D009368:Neoplasm Transplantation; D011120:Polyomavirus / Q000378:metabolism / Q000502:physiology*; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D017526:Receptor, IGF Type 1 / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000378:metabolism; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D051153:Wnt Proteins
D000957:Antigens, Viral, Tumor; D036341:Intercellular Signaling Peptides and Proteins; D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53; D051153:Wnt Proteins; D017526:Receptor, IGF Type 1