title: Ginsenoside-Rd from Panax notoginseng enhances astrocyte differentiation from neural stem cells.
abstract: Neural stem cells cultured as neurospheres were used to assess the effects of P. notoginseng on the production of neurons and glia. The crude saponins (PNS) and ginsenoside-Rd promote the differentiation of neurospheres into astrocytes. Ginsenoside-Rd increases the production of astrocytes in a dose-dependent manner. On the other hand, both PNS and ginsenoside-Rd induce a weak but significant effect by decreasing the number of neurons. The other ginsenosides do not induce any differentiation on both neurons and astrocytes.
authors.affiliation: Laboratoire de Chimie Organique des Substances Naturelles, UMR CNRS-ULP 7123, 5 rue Blaise Pascal 67084 Strasbourg, France.
authors.forename: Qin
authors.initials: Q
authors.lastname: Shi
authors.forename: Qi
authors.initials: Q
authors.lastname: Hao
authors.forename: Julien
authors.initials: J
authors.lastname: Bouissac
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Songjiu
authors.initials: S
authors.lastname: Tian
authors.forename: Bang
authors.initials: B
authors.lastname: Luu
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D036145:Ginsenosides / Q000494:pharmacology*; D051379:Mice; D009474:Neurons / Q000166:cytology*; D005894:Panax / Q000737:chemistry; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects*
chemical_list: D036145:Ginsenosides; C049863:ginsenoside Rd