title: Large loop excision and cold coagulation for management of cervical intraepithelial neoplasia.
abstract: OBJECTIVE
  To evaluate the efficacy of large loop excision of the transformation zone (LLETZ) combined with a single application of the cone probe of a Semm Cold Coagulator as a new treatment for women with cervical intraepithelial neoplasia (CIN).
  
  
  METHODS
  Retrospective case-record review of 666 women treated with large loop excision and cold coagulation (LLECC) from 1992 to 2000.
  
  
  RESULTS
  Of the women who had high-grade CIN at their initial consultation, 4.2% had abnormal cytologic results 6 months after treatment and 0.6% had abnormal cytologic results at 12 months. Of the women who had low-grade CIN at initial presentation, 3.8% had abnormal cytologic results 6 months after treatment and none (0%) at 12 months. Furthermore, there were no reported cases of cervical cancer in this cohort of women during the follow-up period. Short-term bleeding complications (within 24 h of the procedure) occurred in 1% of the women assessed.
  
  
  CONCLUSIONS
  Large loop excision combined with cold coagulation is a new and effective treatment for CIN. Randomized controlled trials are required to confirm these findings and determine the long-term safety of the technique.
authors.affiliation: Department of Obstetrics and Gynaecology, Royal Alexandra Hospital, Corsebar Road, Paisley, PA2 9PN, UK.
authors.forename: M
authors.initials: M
authors.lastname: Allam
authors.forename: A
authors.initials: A
authors.lastname: Paterson
authors.forename: A
authors.initials: A
authors.lastname: Thomson
authors.forename: B
authors.initials: B
authors.lastname: Ray
authors.forename: C
authors.initials: C
authors.lastname: Rajagopalan
authors.forename: G
authors.initials: G
authors.lastname: Sarkar
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000601:surgery*; D017679:Cryotherapy / Q000295:instrumentation / Q000379:methods; D005260:Female; D006801:Humans; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000601:surgery / Q000628:therapy*; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000601:surgery / Q000628:therapy*