Early failure of a tricuspid valve replacement with a mitral valve homograft in a heart transplant recipient.
A 24-year-old woman experienced severe tricuspid valve regurgitation 6 years after heart transplantation. Tricuspid valve replacement was performed using a cryopreserved mitral valve homograft. Severe tricuspid valve regurgitation recurred within 4 months, associated with an increase in the panel reactive antibody titers from zero to 72%. Tricuspid valve replacement was repeated with a porcine bioprosthesis with excellent recovery and function for >2 years. The mitral valve homograft displayed inflammatory features consistent with humoral immune-mediated destruction.
Alharethi
Rami
R
Utah Transplantation Affiliated Hospitals (UTAH) Cardiac Transplant Program, LDS Hospital, Primary Children's Medical Center, Salt Lake City, Utah 84143, USA.
Shaddy
Robert E
RE
Doty
Donald B
DB
Moore
Stephanie A
SA
Hammond
M Elizabeth H
ME
Dabbas
Bashar
B
Fuller
Thomas C
TC
Renlund
Dale G
DG
D000328:Adult; D001705:Bioprosthesis; D002311:Cardiomyopathy, Dilated / Q000601:surgery; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D016027:Heart Transplantation; D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve / Q000637:transplantation*; D011183:Postoperative Complications; D012008:Recurrence; D014184:Transplantation, Homologous; D014262:Tricuspid Valve Insufficiency / Q000473:pathology / Q000601:surgery*
D006680:HLA Antigens