[Identification of factors influencing the response of antiretroviral treatment].
OBJECTIVE
The authors had an aim to define the ideal patient profile by determining the factors responsible for an initial variation of CD4 lymphocytes and viral load, and the effect of these factors on the therapeutic response after 12 months of treatment in HIV infected patients.


METHODS
A retrospective study was made on data concerning the clinical stage, the HIV phenotype strain, the therapeutic status, and the type of treatment. This data was compared to the CD4 count and the viral load before and after 12 months of treatment.


RESULTS
Initially, CD4 lymphocytes values were low in case of: phenotype SI (p = 0.012), patient in clinical stage C (p < 0.0001), or treated with protease inhibitor (p < 0.0002). The viral loads were high for patients in stage C (p < 0.0002) and treated with protease inhibitor (p < 0.0001). After 12 months of treatment, the increase of CD4 count was lower in patients with phenotype SI (p = 0.05). Furthermore, the viral load was statistically more important in naive patient (p < 0.0001).


CONCLUSIONS
According to our study, the ideal patient is naive and presents with phenotype NSI.
Nkoghe
D
D
Service de médecine interne et maladies infectieuses, CHU de Liège, Belgique b BP 5879 Libreville, Gabon. dnkoghe@hotmail.com
Nnégué
S
S
Léonard
P
P
Moutschen
M
M
Demonty
J
J
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D006678:HIV / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016896:Treatment Outcome
D019380:Anti-HIV Agents