[Study on the anticancer activities (in vivo) of the extract from Citrus reticulata Blanco and its influence on sarcoma-180 cells cycle].
OBJECTIVE
To study the anticancer activity of the extract from Citrus reticulata in vivo.


METHODS
Anticancer activities were tested with tumor model in vivo (Sarcoma-180 cells, Heps cells, EAC cells implanted in mice).


RESULTS
The extract from Citrus reticulata showed marked anticancer activities on Sarcoma-180 cells and Heps cells implanted in mice, had no marked anticancer activities on EAC cells implanted in mice and induced apoptosis of Sarcoma-180 cell.


CONCLUSIONS
The extract from Citrus reticulata will have promising prospects as an anticancer Chinese medicine, but further studies will be needed.
Qian
Shi-hui
SH
Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China. qshihui@jlonline.com
Wang
Yi-xian
YX
Yang
Nian-yun
NY
Yuan
Li-hong
LH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D002957:Citrus / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005638:Fruit / Q000737:chemistry; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010946:Plants, Medicinal / Q000737:chemistry; D012510:Sarcoma 180 / Q000188:drug therapy / Q000473:pathology*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal