Absorption, distribution, and excretion of [14C]-3-chloro-4-methylaniline hydrochloride in two species of birds following a single oral dose.
Ring-labeled [14C]-3-chloro-4-methylaniline hydrochloride (250 microg per bird) was delivered to 21 red-winged blackbirds (Agelaius phoeniceus) and 21 dark-eyed juncos (Junco hyemalis) via oral gavage, and the distribution and excretion of radioactivity were determined at 15 and 30 min and 1, 4, 8, 12, and 24 h (n = 3 per time point). Direct measurement of radioactivity as well as measurement following combustion was accomplished using a liquid scintillation counter. Elimination from most tissues followed a two-compartment model, with very rapid elimination occurring between time 0 and 4 h and a much slower elimination phase occurring after that. The average half-life of elimination for the initial phase in most tissues examined was 0.16 h for juncos and 0.62 h for blackbirds. The average for the slower second phase of elimination was 3.4 h for juncos and 5.4 h for blackbirds. The radioactivity in blackbird kidney tissues did not change significantly for the duration of the test, pointing toward the kidney as a possible site of action for this important agricultural chemical.
Goldade
David A
DA
National Wildlife Research Center, 4101 LaPorte Avenue, Fort Collins, Colorado 80521, USA. David.A.Goldade@usda.gov
Tessari
John D
JD
Johnston
John J
JJ
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D001717:Birds / Q000378:metabolism*; D002250:Carbon Radioisotopes; D006207:Half-Life; D007700:Kinetics; D007928:Lethal Dose 50; D010575:Pesticides / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014052:Toluidines / Q000008:administration & dosage / Q000493:pharmacokinetics*
D002250:Carbon Radioisotopes; D010575:Pesticides; D014052:Toluidines; C019296:starlicide