Vitamin K2 improves the hematopoietic supportive functions of bone marrow stromal cells in vitro: a possible mechanism of improvement of cytopenia for refractory anemia in response to vitamin K2 therapy.
Miyazawa
Keisuke
K
Aizawa
Shin
S
D000256:Adenoviridae / Q000235:genetics; D000740:Anemia / Q000139:chemically induced / Q000188:drug therapy*; D000933:Antifibrinolytic Agents / Q000494:pharmacology; D018952:Antigens, CD34 / Q000096:biosynthesis; D001854:Bone Marrow Cells / Q000166:cytology*; D018920:Coculture Techniques; D004305:Dose-Response Relationship, Drug; D042783:Endothelial Cells / Q000166:cytology; D004797:Enzyme-Linked Immunosorbent Assay; D006402:Hematologic Diseases / Q000188:drug therapy*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D017154:Stromal Cells / Q000166:cytology*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D024482:Vitamin K 2 / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*
D000933:Antifibrinolytic Agents; D018952:Antigens, CD34; D014409:Tumor Necrosis Factor-alpha; D024482:Vitamin K 2