[Changes in serum endothelin and in pregnant rabbits with pulmonary embolism].
OBJECTIVE
To study change of serum endothelin (ET) and in serum endothelin and in pregnant rabbit with acute pulmonary embolism.


METHODS
In 17 pregnant rabbits, autologous blood clots were administered into the right atrium via the femoral vein to establish the animal models of acute pulmonary embolism, and another 10 pregnant rabbits received injection with saline to serve as the control group. Serum levels of ET and CGRP were measured before, 0, 2, 4, 6 and 8 h after the injection.


RESULTS
Acute pulmonary embolism was induced in all the rabbits receiving the injection of autologous blood clots with a success rate of 100%. In these rabbit models of pulmonary embolism, serum ET increased 0 h after the embolism and kept rising till 6 h, whereas CGRP level underwent immediate decrease after the embolism followed then by increase during the period from 4 to 8 h, showing significant difference from the levels of the control group.


CONCLUSIONS
Significant difference in serum ET and CGRP levels occur in the event of acute pulmonary embolism in pregnant rabbits.
Zhong
Mei
M
Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Cui
Bao-kui
BK
Yu
Yan-hong
YH
Huang
Li-ping
LP
Liu
Bao-ying
BY
Song
Tian-rong
TR
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D016232:Endothelins / Q000097:blood*; D005260:Female; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D011655:Pulmonary Embolism / Q000097:blood*; D011817:Rabbits
D016232:Endothelins; D015740:Calcitonin Gene-Related Peptide