Tau and src family tyrosine kinases.
The interaction between tau and src family non-receptor tyrosine kinases represents a new function for tau. Mediated by the proline-rich region of tau and the SH3 domain of fyn or src, this interaction has the potential to confer novel cellular activities for tau in the growth cone and in the membrane. The subsequent finding that tau is tyrosine phosphorylated has led to the observation that tau in neurofibrillary tangles is tyrosine phosphorylated. Therefore, a role for tyrosine kinases such as fyn in neuropathogenesis is predicted.
Lee
Gloria
G
Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. gloria-lee@uiowa.edu
D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D006801:Humans; D051379:Mice; D009474:Neurons / Q000378:metabolism; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D051381:Rats; D019061:src-Family Kinases / Q000502:physiology*; D016875:tau Proteins / Q000502:physiology*
D016875:tau Proteins; D019061:src-Family Kinases