An experimental design for the development of adaptive treatment strategies.
In adaptive treatment strategies, the treatment level and type is repeatedly adjusted according to ongoing individual response. Since past treatment may have delayed effects, the development of these treatment strategies is challenging. This paper advocates the use of sequential multiple assignment randomized trials in the development of adaptive treatment strategies. Both a simple ad hoc method for ascertaining sample sizes and simple analysis methods are provided.
Murphy
S A
SA
Department of Statistics, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. samurphy@umich.edu
D000465:Algorithms; D002985:Clinical Protocols; D006801:Humans; D015233:Models, Statistical; D011340:Problem Solving; D016032:Randomized Controlled Trials as Topic; D012107:Research Design / Q000706:statistics & numerical data*; D018401:Sample Size; D013812:Therapeutics