Cdc14 and the temporal coordination between mitotic exit and chromosome segregation.
Cell division involves the inheritance of a complete set of the genome in the form of chromosomes. One of the strategies employed by eukaryotic cells is to maintain replicated sister chromatids together until the anaphase onset. A protein complex named cohesin holds sisters together following replication until anaphase when cleavage of cohesin by the protease separase initiates segregation. Recent studies in budding yeast have shown that cohesin cleavage alone is not sufficient for the segregation of the entire genome. Instead, repetitive regions, such as the ribosomal DNA (rDNA) array and telomeres, require additional mechanisms during mitotic disjunction. The segregation of such chromosome regions is delayed and needs specific cell cycle regulators such as the FEAR network and the conserved phosphatase Cdc14, all of which orchestrate the timely completion of chromosome segregation before mitotic exit. Future studies will be targeted towards unravelling the nature of the additional segregation requirements for repetitive regions and the specifics of its cell cycle control.
Torres-Rosell
Jordi
J
Cell Cycle Group, Clinical Sciences Centre, Medical Research Council, Imperial College London, London, UK.
Machín
Félix
F
Aragón
Luis
L
D000251:Adenosine Triphosphatases / Q000502:physiology; D000705:Anaphase / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone; D020090:Chromosome Segregation / Q000235:genetics / Q000502:physiology*; D015825:Chromosomes, Fungal / Q000235:genetics / Q000502:physiology; D004275:DNA, Ribosomal / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D010450:Endopeptidases / Q000502:physiology; D004789:Enzyme Activation / Q000502:physiology; D005656:Fungal Proteins / Q000502:physiology; D008938:Mitosis / Q000235:genetics / Q000502:physiology*; D046912:Multiprotein Complexes / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*; D004718:Saccharomycetales / Q000166:cytology* / Q000502:physiology; D064247:Separase; D016615:Telomere / Q000502:physiology; D014158:Transcription, Genetic; D000097722:Cohesins
D000251:Adenosine Triphosphatases; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004275:DNA, Ribosomal; D004268:DNA-Binding Proteins; D010450:Endopeptidases; D005656:Fungal Proteins; D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D017027:Protein Tyrosine Phosphatases; D029701:Saccharomyces cerevisiae Proteins; D064247:Separase; D000097722:Cohesins; C074860:CDC14 protein, S cerevisiae; C108312:condensin complexes; C577986:ESP1 protein, S cerevisiae