title: [Effect of tea polyphenol on liver fibrosis in rats and related mechanism].
abstract: OBJECTIVE
  To investigate the effect of tea polyphenol (TP)'s on liver fibrosis in rats and its possible mechanism.
  
  
  METHODS
  Rats were divided into 5 groups, 4 groups of which were stomach perfused with alcohol resulting in alcoholic liver fibrosis, and 3 groups of which were stomach perfused with TP simultaneously. Another group was normal control one. Histological change of rat liver was investigated and quantitative analysis was made in 24 weeks, and rat liver anti-oxidation index and serum endotoxin were determined at the same time.
  
  
  RESULTS
  Liver fibrosis in TP group was slight, and anti-oxidize index and endotoxin level were markedly improved in comparison with those of alcohol groups.
  
  
  CONCLUSIONS
  Tea polyphenol can protect hepatocytes from fibrosis. Its mechanism is possibly due to cleaning up overfull lipid per-oxidation and reducing the level of endotoxin.
authors.affiliation: The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China. ZXG777@sohu.com
authors.forename: Xing-guo
authors.initials: XG
authors.lastname: Zhang
authors.forename: Chao-hui
authors.initials: CH
authors.lastname: Yu
authors.forename: Yu-e
authors.initials: YE
authors.lastname: Qing
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shao-hua
authors.initials: SH
authors.lastname: Chen
authors.forename: You-ming
authors.initials: YM
authors.lastname: Li
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D004731:Endotoxins / Q000097:blood*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D005978:Glutathione / Q000097:blood; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood* / Q000209:etiology / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000150:complications*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D059808:Polyphenols; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D013662:Tea / Q000737:chemistry
chemical_list: D004731:Endotoxins; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D020011:Protective Agents; D013662:Tea; D008315:Malondialdehyde; D003094:Collagen; D013482:Superoxide Dismutase; D005978:Glutathione