Is there a link between malignant hyperthermia and exertional heat illness?
Exertional heat illness (EHI) and malignant hyperthermia (MH) are two potentially lethal conditions. It has been suggested that a subset of MH susceptible persons may be predisposed to EHI. We examine the current understanding of these disorders and explore evidence of a relationship. Screening for the muscle type I ryanodine receptor gene should help clarify the relationship between MH and EHI.
Muldoon
Sheila
S
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. smuldoon@usuhs.mil
Deuster
Patricia
P
Brandom
Barbara
B
Bunger
Rolf
R
D000138:Acidosis / Q000235:genetics / Q000378:metabolism; D000293:Adolescent; D002648:Child; D003620:Dantrolene / Q000627:therapeutic use; D017809:Fatal Outcome; D020022:Genetic Predisposition to Disease; D006359:Heat Exhaustion / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D018882:Heat Stress Disorders / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D009125:Muscle Relaxants, Central / Q000627:therapeutic use; D009154:Mutation; D005082:Physical Exertion; D012307:Risk Factors; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics / Q000378:metabolism
D009125:Muscle Relaxants, Central; D019837:Ryanodine Receptor Calcium Release Channel; D003620:Dantrolene