Finding the maximum safe dose level for heteroscedastic data.
In this article we extend to the heteroscedastic setting the multiple stepwise test procedures proposed in Tamhane et al. [Tamhane. A. C., Dunnett, C. W., Green, J. W., Wetherington, J. F. (2001). Multiple test procedures for identifying a safe dose. J. Am. Statist. Assoc. 96:835-843] for finding the maximum safe dose. Toxicological data are often heteroscedastic; therefore, the extensions given herein should be highly useful in practice. Simulations are performed to study the Type I familywise error rate and power properties of the procedures. A real data example is given to illustrate the procedures.
Tamhane
Ajit C
AC
Departments of IE/MS and of Statistics, Northwestern University, Evanston, IL 60208, USA. ajit@iems.northwestern-edu
Logan
Brent R
BR
D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions; D009010:Monte Carlo Method; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D051381:Rats
D004364:Pharmaceutical Preparations