The relationship between risk factors and testosterone-induced relaxations in human internal mammary artery.
In human internal mammary artery (IMA), testosterone induces vasodilation that shows marked variability among patients. We aimed to investigate the relationship of this variability with cardiovascular risk factors. Cumulative relaxations to testosterone after precontraction with KCl were examined in IMA segments from patients with identified cardiovascular risk factors such as hypercholesterolemia, diabetes, hypertension, smoking, age, gender, body mass index (BMI), and number of occluded vessels. Testosterone responses were significantly diminished in subjects with 3 compared with 1 risk factor. Hypercholesterolemia independently influenced testosterone responses by significantly decreasing its maximum, and smoking significantly decreased the sensitivity to testosterone. Thus, the variability observed in testosterone-induced vascular relaxations may in part be related to differences in risk factors present among the individuals studied.
Yildiz
Oguzhan
O
Department of Pharmacology, Gulhane Military Medical Academy, Ankara, Turkey. oyildiz@gata.edu.tr
Seyrek
Melik
M
Un
Ismail
I
Gul
Husamettin
H
Candemir
Goknur
G
Yildirim
Vedat
V
D000367:Age Factors; D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology; D003920:Diabetes Mellitus / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000503:physiopathology; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D008323:Mammary Arteries / Q000187:drug effects* / Q000503:physiopathology; D008875:Middle Aged; D017534:Radial Artery / Q000187:drug effects / Q000503:physiopathology; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects / Q000503:physiopathology; D013739:Testosterone / Q000494:pharmacology* / Q000502:physiology; D014469:Umbilical Arteries / Q000187:drug effects / Q000503:physiopathology; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology
D013739:Testosterone