title: Early failure of a tricuspid valve replacement with a mitral valve homograft in a heart transplant recipient.
abstract: A 24-year-old woman experienced severe tricuspid valve regurgitation 6 years after heart transplantation. Tricuspid valve replacement was performed using a cryopreserved mitral valve homograft. Severe tricuspid valve regurgitation recurred within 4 months, associated with an increase in the panel reactive antibody titers from zero to 72%. Tricuspid valve replacement was repeated with a porcine bioprosthesis with excellent recovery and function for >2 years. The mitral valve homograft displayed inflammatory features consistent with humoral immune-mediated destruction.
authors.affiliation: Utah Transplantation Affiliated Hospitals (UTAH) Cardiac Transplant Program, LDS Hospital, Primary Children's Medical Center, Salt Lake City, Utah 84143, USA.
authors.forename: Rami
authors.initials: R
authors.lastname: Alharethi
authors.forename: Robert E
authors.initials: RE
authors.lastname: Shaddy
authors.forename: Donald B
authors.initials: DB
authors.lastname: Doty
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Moore
authors.forename: M Elizabeth H
authors.initials: ME
authors.lastname: Hammond
authors.forename: Bashar
authors.initials: B
authors.lastname: Dabbas
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Fuller
authors.forename: Dale G
authors.initials: DG
authors.lastname: Renlund
mesh_terms: D000328:Adult; D001705:Bioprosthesis; D002311:Cardiomyopathy, Dilated / Q000601:surgery; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D016027:Heart Transplantation; D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve / Q000637:transplantation*; D011183:Postoperative Complications; D012008:Recurrence; D014184:Transplantation, Homologous; D014262:Tricuspid Valve Insufficiency / Q000473:pathology / Q000601:surgery*
chemical_list: D006680:HLA Antigens