title: Elimination of Pancoast tumor by carboplatin, paclitaxel, and concurrent radiation.
abstract: Preoperative chemoradiotherapy with carboplatin (AUC 1.5), paclitaxel (40 mg/m2), and concurrent extracorporeal radiation (40 Gy) was used to treat a Pancoast tumor (clinical T3N0M0), without causing adverse events. Then left upper lobectomy was performed along with mediastinal lymph node dissection plus resection of the chest wall and Th1 nerve root. Histological examination revealed a pathological complete response. This multimodal regimen was feasible and achieved a good response, so it seems worthwhile to evaluate the clinical effectiveness of the therapy in a cohort study.
authors.affiliation: Department of Surgery, Osaka Kosei-Nenkin Hospital, 4-2-78 Fukushima, Fukushima-ku, Osaka 553-0003, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Utsumi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Midori
authors.initials: M
authors.lastname: Tamura
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ohno
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D010178:Pancoast Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D011859:Radiography
chemical_list: D016190:Carboplatin; D017239:Paclitaxel