title: Topical application of ionic polymers affects skin permeability barrier homeostasis.
abstract: We previously demonstrated that the external electric potential affected skin barrier homeostasis. On the other hand, topical application of an ionic polymer formed a diffusion electric double layer on the surface of the skin. Thus, we evaluated effects of topical application of ionic polymers on the damaged skin barrier. Application of a nonionic polymer did not affect barrier recovery. Application of sodium salts of anionic polymers accelerated barrier recovery, while that of cationic polymers delayed it. Topical application of a sodium-exchange resin accelerated barrier recovery, but application of a calcium-exchange resin had no effect even when the resins had the same structure. Application of a chloride-exchange resin delayed barrier recovery. Topical application of ionic polymers influenced skin barrier homeostasis.
authors.affiliation: Shiseido Research Center, 2-12-1 Fukuura, Kanazawa-ku, Yokohama, 236-8643, Japan. mitsuhiro.denda@to.shiseido.co.jp
authors.forename: M
authors.initials: M
authors.lastname: Denda
authors.forename: K
authors.initials: K
authors.lastname: Nakanishi
authors.forename: N
authors.initials: N
authors.lastname: Kumazawa
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000838:Anions / Q000493:pharmacokinetics; D002412:Cations / Q000493:pharmacokinetics; D002480:Cellulase / Q000493:pharmacokinetics; D048271:Chitosan / Q000493:pharmacokinetics; D002809:Chondroitin Sulfates / Q000493:pharmacokinetics; D004594:Electrophysiology; D004817:Epidermis / Q000502:physiology; D006493:Heparin / Q000493:pharmacokinetics; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D011095:Polyethylenes / Q000493:pharmacokinetics; D011108:Polymers / Q000493:pharmacokinetics*; D011142:Polyvinyl Alcohol / Q000493:pharmacokinetics; D000644:Quaternary Ammonium Compounds / Q000493:pharmacokinetics; D012869:Skin Absorption / Q000187:drug effects* / Q000502:physiology
chemical_list: D000838:Anions; D002412:Cations; D011095:Polyethylenes; D011108:Polymers; D000644:Quaternary Ammonium Compounds; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; D011142:Polyvinyl Alcohol; D006493:Heparin; D002809:Chondroitin Sulfates; D048271:Chitosan; D002480:Cellulase; C019826:carboxymethylcellulase