[CD11b and CD62L receptors expression on neutrophils after laparoscopic versus open cholecystectomy].
The development of immunology correlated with surgery enables close recognition of multiple mechanisms responsible for more frequent complications observed after open surgical procedures than after minimally invasive operations.


OBJECTIVE
Evaluation of selected elements of non-specific immunity in patients undergoing open cholecystectomy (OC) versus laparoscopic cholecystectomy (LC).


METHODS
30 postmenopausal females with non-complicated cholecystolithiasis were analysed. Both OC and LC was performed in 15 cases. Blood samples for an analysis were collected 24 hours before surgery and 24 and 72 hours postoperatively. Qualitative changes of neutrophils measured by the expression of CD11b and CD62L receptors on their surface without or with formyl-methionyl-leucyl-phenylalanine (fMLP) stimulation were evaluated.


RESULTS
The expression of CD11b and CD62L receptors show no significant changes in patients that underwent LC while patients that underwent OC had significant changes 24 hours postoperatively compared both with their preoperative values and values observed in patients after LC.


CONCLUSIONS
The activation of neutrophils measured by changes of the expression of CD11b and CD62L receptors on their surface is connected with the magnitude of trauma and is only observed in patients after OC.
Kordiak
Jacek
J
Klinika Chirurgii Ogólnej i Torakochirurgii UM w Lodzi. jkordiak@interia.pl
Bella
Mariusz
M
Rysz
Jacek
J
Jabłoński
Sławomir
S
Brocki
Marian
M
Kowalska
Barbara
B
Kutwin
Leszek
L
Niemirowicz
Maciej
M
Gruda
Robert
R
Wcisło
Szymon
S
D000368:Aged; D039481:CD11b Antigen / Q000276:immunology / Q000378:metabolism*; D017081:Cholecystectomy, Laparoscopic / Q000379:methods*; D041761:Cholecystolithiasis / Q000276:immunology / Q000378:metabolism* / Q000601:surgery*; D005260:Female; D006801:Humans; D019041:L-Selectin / Q000276:immunology / Q000378:metabolism*; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism*; D011182:Postoperative Care; D011446:Prospective Studies
D039481:CD11b Antigen; D019041:L-Selectin