Synthesis and antiviral activity against Coxsackie virus B3 of some novel benzimidazole derivatives.
Some benzimidazole derivatives were synthesized and evaluated for their antiviral properties. Compounds 20 and 21 showed potent selective activity against Coxsackie virus B(3) in VERO cells. Some structure-activity relationships were discussed.
Cheng
Jun
J
School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240, PR China.
Xie
Jiangtao
J
Luo
Xianjin
X
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D029822:Enterovirus B, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D001562:Benzimidazoles