Transcription factors, pancreatic development, and beta-cell maintenance.
Transcription factors play an important role during pancreatic development ensuring normal differentiation of the islet endocrine cells. In mature beta-cells, expression of specific transcription factors is essential in maintaining normal beta-cell function.
Cerf
M E
ME
Diabetes Research Group, Medical Research Council, Tygerberg, South Africa. marlon.cerf@mrc.ac.za
Muller
C J F
CJ
Du Toit
D F
DF
Louw
J
J
Wolfe-Coote
S A
SA
D000818:Animals; D002454:Cell Differentiation; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000473:pathology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007515:Islets of Langerhans / Q000254:growth & development* / Q000378:metabolism* / Q000473:pathology; D010179:Pancreas / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism* / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors