In vitro chemosensitivity to gemcitabine, oxaliplatin and zoledronic acid predicts treatment response in metastatic gastric cancer.
Individual response of disseminated cancer to chemotherapy is unpredictable. In vitro chemotherapy-induced apoptosis can be measured and might be a method to evaluate in vivo activity of tested drugs. In this report, tumor cells of a patient with signet cell carcinoma of the stomach and diffuse bone marrow infiltration were cultured and tested for in vitro chemosensitivity. The drugs gemcitabine, oxaliplatin and zoledronic acid were found to induce in vitro tumor cell apoptosis synergistically, and subsequently were used as combination chemotherapy regimen. An initially existing disseminated intravascular coagulopathy quickly resolved and after 6 months of treatment on ongoing complete response was induced, thus confirming the results of in vitro chemosensitivity testing.
Trojan
Jörg
J
Division of Gastroenterology, Department of Internal Medicine, Johann Wolfgang Goethe University Medical Center, Frankfurt, Germany. trojan@em.uni-frankfurt.de
Kim
Soo-Zin
SZ
Engels
Knut
K
Kriener
Susanne
S
Mitrou
Paris S
PS
Chow
Kai U
KU
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy* / Q000556:secondary; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004164:Diphosphonates / Q000008:administration & dosage; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D008297:Male; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D011237:Predictive Value of Tests; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014407:Tumor Cells, Cultured; D000077211:Zoledronic Acid; D000093542:Gemcitabine
D004164:Diphosphonates; D007093:Imidazoles; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D003841:Deoxycytidine; D000077211:Zoledronic Acid; D000093542:Gemcitabine