title: Dilated versus nondilated cardiomyopathy in the elderly population treated with guideline-based medical therapy for systolic chronic heart failure.
abstract: BACKGROUND
  Although the process by which the left ventricular (LV) remodels in response to an injury generally leads to dilatation, in patients with heart failure (HF) the recognition of a small or mildly dilated left ventricle is not uncommon. We investigated the prevalence and the characteristics of elderly patients with traditional dilated and nondilated cardiomyopathy (CMP). We also assessed the response to the guideline-based medical therapy and the prognosis based on LV dilatation in this population.
  
  
  RESULTS
  We selected 243 patients >70 years of age with HF and LV ejection fraction <40% who underwent clinical and echocardiographic evaluations at baseline and after 12 months. They were subdivided into 2 groups according to baseline LV end-diastolic volume (LVEDV) (values < or =78 mL/m(2) identified nondilated CMP). Nondilated CMP was recognized in 64 patients (26%) who showed at baseline better clinical status, less severe mitral regurgitation, and higher LV ejection fraction than those with dilated CMP. At the final evaluation, favorable changes in clinical and echocardiographic parameters could be detected in both groups. The magnitude of these variations did not differ between the groups. The risk of hospitalization for worsening HF was 2.4-fold higher in patients with nondilated than dilated CMP. Mortality was 11% and 20%, respectively (P = .06). Statistical analysis revealed a direct, approximately linear relationship between LVEDV and outcomes in this population.
  
  
  CONCLUSIONS
  A total of 1 of 4 elderly patients with systolic HF had a nondilated left ventricle. These patients had a better clinical presentation than did counterparts with dilated left ventricles. After HF therapy is optimized, the likelihood of improvement is independent of LV size in this population, whereas the risk of death or worsening HF linearly increases with LV dilatation.
authors.affiliation: Department of Cardiology, Villa Bianca Hospital, Via Piave 78, 38100, Trento, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cioffi
authors.forename: Luigi
authors.initials: L
authors.lastname: Tarantini
authors.forename: Stefania
authors.initials: S
authors.lastname: De Feo
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pulignano
authors.forename: Donatella
authors.initials: D
authors.lastname: Del Sindaco
authors.forename: Carlo
authors.initials: C
authors.lastname: Stefenelli
authors.forename: Cristina
authors.initials: C
authors.lastname: Opasich
authors.forename: Cristina
authors.initials: C
authors.lastname: Pasich
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002311:Cardiomyopathy, Dilated / Q000453:epidemiology* / Q000503:physiopathology; D015897:Comorbidity; D004108:Dilatation, Pathologic; D005260:Female; D006333:Heart Failure / Q000453:epidemiology* / Q000503:physiopathology; D006352:Heart Ventricles / Q000473:pathology; D006439:Hemodynamics; D006801:Humans; D016015:Logistic Models; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000453:epidemiology* / Q000503:physiopathology