Investigation of the effects of tianeptine and fluoxetine on pentylenetetrazole-induced seizures in rats.
The effects of tianeptine and fluoxetine on pentylenetetrazole (PTZ)-induced seizures in rats were investigated. Female Wistar rats (172-278 g) were used in the study. Tianeptine (1.25, 2.5, 5, 10 and 20 mg/kg) and fluoxetine (2.5, 5, 10 and 20 mg/kg) or saline were injected to rats intraperitoneally 30 min before PTZ (50 mg/kg) injections. Immediately after PTZ administrations, latency and intensity of the PTZ-induced seizures was recorded and scored, respectively. Fluoxetine (2.5-20 mg/kg) did not produce any significant difference in latency and intensity of the PTZ-induced seizures. Although tianeptine (1.25-20 mg/kg) also did not affect the latency time, it produced significant attenuations in the intensity of the seizures. Tianeptine did not cause any significant change in the locomotor activity of the rats. The results of this preliminary study suggest that tianeptine but not fluoxetine has some inhibitory effects on PTZ-induced seizures in rats.
Ceyhan
Mert
M
Psychopharmacology Research Unit, Department of Medical Pharmacology, Faculty of Medicine, Gülhane Military Medical Academy, Etlik, Ankara 06018, Turkey.
Kayir
Hakan
H
Uzbay
I Tayfun
IT
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D007263:Infusions, Parenteral; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013841:Thiazepines / Q000494:pharmacology*
D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D003292:Convulsants; D013841:Thiazepines; D005473:Fluoxetine; C050504:tianeptine; D010433:Pentylenetetrazole