[Physiopathology of bipolar disorders: what have changed in the last 10 years?].
Despite recent efforts to understand the neurobiology of Bipolar Disorder (BD), the exact pathophysiology remains undetermined. Due to the effects of various psychopharmacological agents, initial research focused on the study of biogenic amines. Recent evidence has shown that dysfunction in intracellular signaling systems and gene expression may be associated with BD. These alterations may cause interruptions in mood regulating circuits such as the limbic system, striatum and prefrontal cortex, and the neuroprotective effects of mood stabilizers may reverse this pathological process. This study aims to update the recent findings relative to the neurochemistry of BD.
Kapczinski
Flávio
F
Laboratório de Psiquiatria Experimental, Centro de Pesquisas, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS. kapcz@terra.com.br
Frey
Benício Noronha
BN
Zannatto
Vanessa
V
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D002908:Chronic Disease; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D014150:Antipsychotic Agents; D036341:Intercellular Signaling Peptides and Proteins; D018377:Neurotransmitter Agents