[Short-term effect of nebivolol on the left ventricular diastolic function].
OBJECTIVE
To determine the effects of nebivolol on diastolic functions of the left ventricle in the hypertensive patients in the early treatment period.


METHODS
Twenty patients with mild to moderate hypertension taking daily 5 mg of nebivolol were assessed by using Doppler echocardiography before and after 6-week drug treatment period. The results were analyzed with Wilcoxon test and p<0.05 was accepted as statistically significant value.


RESULTS
The arterial blood pressure and heart rate of the patients significantly decreased after 6 weeks of treatment. Statistically significant decrease was found in the peak of A wave velocity, isovolumetric relaxation time, E wave deceleration time and increase in E/A ratio with Doppler echocardiography after 6-week treatment period. No statistically significant difference was observed in the peak velocity of E wave after treatment period.


CONCLUSIONS
We found that nebivolol improved left ventricular diastolic function in patients with hypertension in the early term.
Demiralp
Ergün
E
Department of Cardiology, Haydarpaşa Education Hospital, Gülhane Military Medical Academy, Istanbul.
Kardeşoğlu
Ejder
E
Celik
Turgay
T
Cebeci
Bekir Sitki
BS
Ozmen
Namik
N
Işilak
Zafer
Z
Ulusoy
Rifat Eralp
RE
Dinçtürk
Mehmet
M
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001578:Benzopyrans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D015150:Echocardiography, Doppler; D004983:Ethanolamines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol; D012720:Severity of Illness Index; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*; D016277:Ventricular Function, Left / Q000187:drug effects*
D000959:Antihypertensive Agents; D001578:Benzopyrans; D004983:Ethanolamines; D000068577:Nebivolol