[Characterization of Me. PEG-PLA copolymer nanoparticles prepared by modified spontaneous emulsion-solvent evaporation].
OBJECTIVE
Characterization of poly (D, L-lactic acid)/monomethylether terminated/polyethylene glycol (Me. PEG-PLA) block copolymers nanoparticles.


METHODS
Me. PEG-PLA block copolymers were prepared by bulk polymerization. A series of nanoparticles were made from Me. PEG-PLA block copolymer by modified spontaneous emulsion-solvent evaporation technique.


CONCLUSIONS
The structure of copolymer was performed by means of 1HNMR and FT-IR. The morphological examination of nanoparticles was performed by means of atomic force microscope (AFM). Results indicated that nanoparticles exhibited a smooth spherulite and core-shell structure. The hydrophilic shell is consisted of PEG segments and hydrophobic core is consisted of PLA segments. Zeta potential of nanoparticles was zero and further indicated core-shell structure. The particle size and size distribution of nanoparticles were measured by laser light scattering technique. The effective particle size range was from 70 to 160 nm and showed a normal distribution.
Dong
Jing
J
Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China.
Liu
Ming-xing
MX
Yang
Ya-jiang
YJ
Xu
Hui-bi
HB
Yang
Xiang-liang
XL
D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D004655:Emulsions; D018625:Microscopy, Atomic Force; D036103:Nanotechnology; D010316:Particle Size; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*
D004337:Drug Carriers; D004655:Emulsions; D011091:Polyesters; D011092:Polyethylene Glycols; C033616:poly(lactide)