title: NPY neurons express somatostatin receptor subtype 1 in the arcuate nucleus.
abstract: The regulation of growth hormone (GH) secretion involves hypothalamic somatostatin and its specific receptors (sst1-sst5). sst1 is highly expressed in the arcuate nucleus (AN), and several data suggest that sst1 receptors are preferentially involved in the somatotropic hypothalamic network. Neuropeptide Y (NPY)-containing neurons function as direct transducers for GH feedback. Interestingly, there is an overlap in the distribution of NPY and sst1 containing cells in the AN. To determine whether these NPY cells are target for somatostatin we used a double label in situ hybridization histochemistry. Image analysis revealed that approximately 7% of NPY-hybridizing neurons coexpressed sst1 mRNA. These results further support the evidence for the direct interactions between the somatotropic axis and the neuroendocrine regulatory loops of energy homeostasis.
authors.affiliation: Department of Pediatrics, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. fodor@vumc.nl
authors.forename: Mariann
authors.initials: M
authors.lastname: Fodor
authors.forename: Eef J
authors.initials: EJ
authors.lastname: van Elk
authors.forename: Carla T
authors.initials: CT
authors.lastname: Huizinga
authors.forename: Tamara
authors.initials: T
authors.lastname: Prins
authors.forename: Henriette A
authors.initials: HA
authors.lastname: Delemarre-van de Waal
mesh_terms: D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology*; D009478:Neuropeptide Y / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D017481:Receptors, Somatostatin / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D009478:Neuropeptide Y; D012333:RNA, Messenger; D017481:Receptors, Somatostatin; C101130:somatostatin receptor type 1