title: [Benzylthiouracil induced ANCA-positive vasculitis].
abstract: BACKGROUND
  Several cases of vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA) have been reported in patients treated with synthetic anti-thyroid drugs but only 2 cases have incriminated benzylthiouracil.
  
  
  METHODS
  A 36 year-old woman, 3 years after treatment with benzylthiouracil, rapidly developed progressive kidney failure, related to a pauci-immune extra-capillary glomerular nephropathy and necrotic vasculitis lesions. The search for p-ANCA was positive with anti-myeloperoxidase specificity. She was treated with corticosteroids and 6 monthly intravenous pulses of cyclophosphamide substituted by azathioprine. Renal failure and proteinuria significantly improved. However the high level of p-ANCA.
  
  
  CONCLUSIONS
  ANCA vascularities are a rare but serious complication of treatment with synthetic thiouracile-type anti-thyroid drugs. The ANCA must be measured when confronted with a systemic manifestation during treatment.
authors.affiliation: Service de médecine interne, Hôpital La Rabta, Tunis, Tunisie.
authors.forename: Amel
authors.initials: A
authors.lastname: Braham
authors.forename: Med Habib
authors.initials: MH
authors.lastname: Houman
authors.forename: Lamia
authors.initials: L
authors.lastname: Rais
authors.forename: Imed
authors.initials: I
authors.lastname: Ben Gborbel
authors.forename: Mounir
authors.initials: M
authors.lastname: Lamloum
authors.forename: Mohamed
authors.initials: M
authors.lastname: Miled
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis / Q000276:immunology*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D013889:Thiouracil / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D014543:Uridine Phosphorylase / Q000037:antagonists & inhibitors; D014657:Vasculitis / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000305:Adrenal Cortex Hormones; D000974:Antibodies, Antinuclear; D013889:Thiouracil; D014543:Uridine Phosphorylase; C019269:benzylthiouracil