title: Piperitone from Mentha longifolia var. chorodictya Rech F. reduces the nitrofurantoin resistance of strains of enterobacteriaceae.
abstract: The diluted essential oil of Mentha longifolia (L.) var. chlorodictya Rech F. foliage enhanced the bactericidal activity of nitrofurantoin decreasing the minimum inhibitory concentration (MIC) of nitrofurantoin for nitrofurantoin-resistant strains of Enterobacteriaceae. Thin-layer chromatography (TLC) analysis of the essential oil detected a fraction (R(f) = 0.35, UV lambda(max) of 232.5), which was the most effective in enhancement of nitrofurantoin activity. Using gas liquid chromatography and known standards, the active fraction was identified as piperitone. 1 microl of the piperitone fraction decreased the MIC of nitrofurantoin 3-20 fold for the different strains of Enterobacteriaceae tested.
authors.affiliation: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. shahverd@sina.tums.ac.ir
authors.forename: A R
authors.initials: AR
authors.lastname: Shahverdi
authors.forename: F
authors.initials: F
authors.lastname: Rafii
authors.forename: F
authors.initials: F
authors.lastname: Tavassoli
authors.forename: M
authors.initials: M
authors.lastname: Bagheri
authors.forename: F
authors.initials: F
authors.lastname: Attar
authors.forename: A
authors.initials: A
authors.lastname: Ghahraman
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000081005:Cyclohexane Monoterpenes; D004347:Drug Interactions; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects*; D006801:Humans; D027541:Mentha; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000892:Anti-Infective Agents, Urinary; D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; D010938:Plant Oils; C496656:piperitone; D009582:Nitrofurantoin