Coordination of activating and inhibitory signals in natural killer cells.
NK cells are equipped with multiple activating and inhibitory cell surface receptors whose engagement regulate NK cell effector function (i.e. cytotoxicity as well as chemokine and cytokine production). Several components (adaptors, effector molecules) that participate to NK cell signalling pathways have been described. Yet, the spatio-temporal organisation of these pathways is still poorly understood. In addition, the mechanisms that integrate several simultaneous input signals in NK cells remain to be elucidated.
Chiesa
Sabrina
S
Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS-Université de la Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France.
Tomasello
Elena
E
Vivier
Eric
E
Vély
Frédéric
F
D020816:Amino Acid Motifs; D000818:Animals; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D011971:Receptors, Immunologic / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*
D011971:Receptors, Immunologic