title: Short-term physiologic response in neophyte subjects fitted with hydrogel and silicone hydrogel contact lenses.
abstract: OBJECTIVE
  To investigate the short-term physiologic response to three soft lens materials with different oxygen permeability characteristics.
  
  
  METHODS
  Forty-three neophytes were randomly prescribed Acuvue 2, Acuvue Advance (Johnson & Johnson Vision Care), or Focus Night & Day (CIBA Vision) for 4 weeks on a daily-wear basis. A further 19 subjects did not wear lenses (control). Experimental and control subjects were examined 2 and 4 weeks after dispensing. Ocular physiologic response was measured with a slitlamp biomicroscope in a strictly masked fashion.
  
  
  RESULTS
  Limbal redness increased in the Acuvue 2 group compared with the other two groups. Conjunctival redness increased more in the Acuvue 2 group than in the Acuvue Advance group. More conjunctival staining was seen with the Acuvue Advance and Focus Night & Day groups compared with the Acuvue 2 group. Increased scores for papillary conjunctivitis were seen in the Focus Night & Day group compared with the Acuvue Advance group.
  
  
  CONCLUSIONS
  The reduced level of limbal redness seen with the Acuvue Advance and Focus Night & Day groups suggests that these lenses provide more oxygen to the ocular surface than the Acuvue 2 lens to a degree that can be observed clinically. The conjunctival staining response was similar for the Acuvue Advance and Focus Night & Day groups. The results for the Acuvue Advance and Focus Night & Day groups for papillary conjunctivitis may reflect differences in their material and surface properties.
authors.affiliation: Eurolens Research, Department of Optometry, The University of Manchester, Manchester, United Kingdom. c.m-codina@manchester.ac.uk
authors.forename: Carole
authors.initials: C
authors.lastname: Maldonado-Codina
authors.forename: Philip B
authors.initials: PB
authors.lastname: Morgan
authors.forename: Cristina M
authors.initials: CM
authors.lastname: Schnider
authors.forename: Nathan
authors.initials: N
authors.lastname: Efron
mesh_terms: D000328:Adult; D003231:Conjunctivitis / Q000209:etiology / Q000378:metabolism; D003263:Contact Lenses, Hydrophilic; D005260:Female; D006801:Humans; D020100:Hydrogels; D008297:Male; D010100:Oxygen / Q000378:metabolism; D017755:Prosthesis Fitting; D012826:Silicone Elastomers
chemical_list: D020100:Hydrogels; D012826:Silicone Elastomers; D010100:Oxygen