title: Design and synthesis of a bimodal target-specific contrast agent for angiogenesis.
abstract: [structure: see text] A bimodal target-specific contrast agent based on a cyclic peptide containing the target-specific NGR sequence, gadolinium(III) diethylenetriaminepentaacetic acid (Gd(III)DTPA), and Oregon Green 488 (OG488) suitable for both MR imaging and optical imaging of angiogenesis is developed. The synthetic strategy for this target-specific contrast agent exploits the use of highly efficient, chemoselective reactions, such as native chemical ligation, and gives a straightforward approach for double labeling of peptides in general.
authors.affiliation: Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
authors.forename: Anouk
authors.initials: A
authors.lastname: Dirksen
authors.forename: Sander
authors.initials: S
authors.lastname: Langereis
authors.forename: Bas F M
authors.initials: BF
authors.lastname: de Waal
authors.forename: Marcel H P
authors.initials: MH
authors.lastname: van Genderen
authors.forename: E W
authors.initials: EW
authors.lastname: Meijer
authors.forename: Quido G
authors.initials: QG
authors.lastname: de Lussanet
authors.forename: Tilman M
authors.initials: TM
authors.lastname: Hackeng
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D019786:Gadolinium DTPA / Q000138:chemical synthesis / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015394:Molecular Structure; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D010456:Peptides, Cyclic / Q000737:chemistry*; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods
chemical_list: D002264:Carboxylic Acids; D003287:Contrast Media; C436864:Oregon Green 488 carboxylic acid; D010456:Peptides, Cyclic; D019786:Gadolinium DTPA