LVV-hemorphin-7 lowers blood pressure in spontaneously hypertensive rats: radiotelemetry study.
Cardiovascular effects of LVV-hemorphin-7, a member of the family of fragments from beta-chain of human or bovine hemoglobin, were studied in conscious spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats by radiotelemetry. Intraperitoneal injection of hemorphin in a dose of 100 microg/kg significantly decreased blood pressure in SHR, whereas negligible effect was seen in normotensive WKY rats. Blood pressure changes were accompanied by reduction of heart rate. In conclusion, a direct effect of LVV-hemorphin-7 on blood pressure was demonstrated in SHR. These biologically active peptides could be involved in blood pressure regulation especially in hypertensive rats, but the precise mechanism should be elucidated.
Cejka
J
J
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Zelezná
B
B
Velek
J
J
Zicha
J
J
Kunes
J
J
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D006454:Hemoglobins / Q000008:administration & dosage*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage*; D051381:Rats; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D013686:Telemetry / Q000379:methods
D006454:Hemoglobins; D010446:Peptide Fragments; C074309:LVV-hemorphin-7