title: Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus.
abstract: Susceptibility to autoimmunity in B6.Sle1b mice is associated with extensive polymorphisms between two divergent haplotypes of the SLAM/CD2 family of genes. The B6.Sle1b-derived SLAM/CD2 family haplotype is found in many other laboratory mouse strains but only causes autoimmunity in the context of the C57Bl/6 (B6) genome. Phenotypic analyses have revealed variations in the structure and expression of several members of the SLAM/CD2 family in T and B lymphocytes from B6.Sle1b mice. T lymphocytes from B6.Sle1b mice have modified signaling responses to stimulation at 4-6 weeks of age. While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly108, a specific isoform of which is constitutively upregulated in B6.Sle1b lymphocytes.
authors.affiliation: Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Wandstrat
authors.forename: Charles
authors.initials: C
authors.lastname: Nguyen
authors.forename: Nisha
authors.initials: N
authors.lastname: Limaye
authors.forename: Alice Y
authors.initials: AY
authors.lastname: Chan
authors.forename: Srividya
authors.initials: S
authors.lastname: Subramanian
authors.forename: Xiang-Hong
authors.initials: XH
authors.lastname: Tian
authors.forename: Young-Sun
authors.initials: YS
authors.lastname: Yim
authors.forename: Alexander
authors.initials: A
authors.lastname: Pertsemlidis
authors.forename: Harold R
authors.initials: HR
authors.lastname: Garner
authors.forename: Laurence
authors.initials: L
authors.lastname: Morel
authors.forename: Edward K
authors.initials: EK
authors.lastname: Wakeland
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D020296:Animals, Congenic; D015703:Antigens, CD; D015551:Autoimmunity / Q000235:genetics / Q000276:immunology; D018801:CD2 Antigens / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation; D006023:Glycoproteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011956:Receptors, Cell Surface; D017422:Sequence Analysis, DNA; D000071176:Signaling Lymphocytic Activation Molecule Family; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1
chemical_list: D015703:Antigens, CD; D018801:CD2 Antigens; D006023:Glycoproteins; D007136:Immunoglobulins; D011956:Receptors, Cell Surface; C000604060:SLAMF6 protein, human; D000071176:Signaling Lymphocytic Activation Molecule Family; C000604063:Slamf6 protein, mouse; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D002118:Calcium