title: Selective effects of antibodies to protein SMP-69 on the activity of defensive behavior command neurons in the common snail.
abstract: The effects of antibodies to the serotonin-modulated protein SMP-69 on the activity of defensive behavior command neurons LP11 and RP11 in semi-intact preparations from common snails were studied. Antibody to SMP-69 increased membrane excitability and facilitated neuron responses to chemical sensory stimulation by application of dilute quinine solution to the animal's head, these effects being seen at 1-1.5 h. The synaptic effects of the antibodies were specific, as they had no influence on responses induced by tactile stimulation of the head. The neuronal effects of antibody SMP-69 were similar to changes in the activity of cells LP11 and RP11 induced by serotonin and cAMP, and to changes seen when snails acquired nociceptive sensitization. It seems likely that a protein homologous to mammalian SMP-69 is involved in the mechanisms controlling excitability and long-term specific plasticity of the synaptic inputs to neurons LP11 and RP11 from chemoreceptors on the snail's head.
authors.affiliation: A. I. Karaev Institute of Physiology, Azerbaidzhan National Academy of Sciences, 2 Sharif-Zale Street, 370100 Baku, Azerbaidzhan.
authors.forename: A A
authors.initials: AA
authors.lastname: Mekhtiev
authors.forename: S A
authors.initials: SA
authors.lastname: Kozyrev
authors.forename: V P
authors.initials: VP
authors.lastname: Nikitin
authors.forename: V V
authors.initials: VV
authors.lastname: Sherstnev
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000528:radiation effects; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D001522:Behavior, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D017952:Ganglia, Invertebrate / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D006372:Helix, Snails / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000276:immunology* / Q000378:metabolism; D009433:Neural Inhibition / Q000187:drug effects / Q000528:radiation effects; D009474:Neurons / Q000145:classification / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D010812:Physical Stimulation / Q000379:methods; D011803:Quinine / Q000009:adverse effects
chemical_list: D018712:Analgesics, Non-Narcotic; D000906:Antibodies; D009419:Nerve Tissue Proteins; D011803:Quinine