title: Correlation between angiogenesis and reduction ratio measured using 201Tl chloride single photon emission computed tomography in patients with oral cavity squamous cell carcinoma.
abstract: OBJECTIVE
  The aim of this study is to examine the correlation between tumor angiogenesis and response to preoperative radiotherapy evaluated using 201Tl single photon emission computed tomography (Tl SPECT) in oral cavity squamous cell carcinoma (SCC).
  
  
  METHODS
  Tl SPECTs before and after preoperative radiotherapy were obtained from 11 patients diagnosed with SCC in oral cavity. Regions of interest were set around the tumor and scalp respectively, and the ratio of mean counts in the tumor to those in the scalp was calculated (T/N). Immunohistochemical staining for investigating microvessel density of pre-treatment biopsy specimen was performed using CD31 monoclonal antibody. We compared microvessel density with semi-quantitative parameters obtained using Tl SPECT (T/N at pre- an post-treatment, reduction ratio) and prognosis.
  
  
  RESULTS
  The subgroup with higher microvessel density showed a significantly higher reduction ratio than the one with lower microvessel density. Regarding prognosis, the subgroup with locoregional recurrent disease exhibited a significantly higher microvessel density than the one without recurrence.
  
  
  CONCLUSIONS
  In SCC of the oral cavity, there was a significant correlation between microvessel density and response to preoperative radiotherapy. Namely, it was revealed that change of 201Tl uptake after preoperative radiotherapy correlated with tumor angiogenesis of oral cavity SCC.
authors.affiliation: Oral and Maxillofacial Surgery, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, Japan. asuzuki.osur@tmd.ac.jp
authors.forename: Aya
authors.initials: A
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Togawa
authors.forename: Junpei
authors.initials: J
authors.lastname: Kuyama
authors.forename: Tadaki
authors.initials: T
authors.lastname: Nakahara
authors.forename: Toshinao
authors.initials: T
authors.lastname: Takenouchi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hatano
authors.forename: Ken
authors.initials: K
authors.lastname: Omura
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000000981:diagnostic imaging / Q000528:radiation effects / Q000601:surgery; D009062:Mouth Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000532:radiotherapy* / Q000601:surgery; D009389:Neovascularization, Pathologic / Q000150:complications / Q000000981:diagnostic imaging*; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013793:Thallium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; C027549:thallium chloride; D013793:Thallium