[An analysis of the infection state of hepatitis C virus in liver diseases].
The local state of hepatitis C virus infection was probed.


METHODS
The markers of hepatitis viruses were tested by nested RT-PCR and ELISA.


RESULTS
In the patients with transfusion history, the incidence of acute hepatitis C (60.53%) was higher than that of acute hepatitis B (10.53%, P<0.01). In the patients with acute hepatitis without transfusion, however, the percentage of type A (41.67%) and type B (30.56%) hepatitis were higher than that of type C hepatitis (4.17%, P<0.01). The incidences of acute and chronic posttransfusion hepatitis C and asymptomatic HCV-infected cases, respectively 60.53%, 20.34% and 29.17%, were higher than that of the cases without transfusion, which were 4.2%, 8.74% and 3.33% respectively (P<0.01-0.05). No matter whether the patients with chronic hepatitis, severe hepatitis, cirrhosis, hepatocellular carcinoma or asymptomatic had transfusion history or not the incidences of HBV infection in them were higher than that of HCV infection (P<0.01).


CONCLUSIONS
Most of the source of HCV infection were from transfusion, but infective rate of HCV by way of non-transfusion was lower. Severe hepatitis, chronic hepatitis, cirrhosis and hepatocellular carcinoma in local area was mostly induced by HBV.
He
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Department of Infectious Diseases, Xiehe Hospital, Tongji Medical University, Wuhan 430022.
Liu
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W
D000328:Adult; D000368:Aged; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification*; D006509:Hepatitis B / Q000821:virology; D006526:Hepatitis C / Q000821:virology; D006801:Humans; D008107:Liver Diseases / Q000821:virology*; D008297:Male; D008875:Middle Aged; D065227:Transfusion Reaction; D055815:Young Adult