Reduction of carboxyhaemoglobin levels in the venous blood of cigarette smokers following the administration of carbogen.
Cigarette smokers have high carboxyhaemoglobin levels which can promote tumour radioresistance. Inhalation of carbogen gas shortens the half-life of carboxyhaemoglobin, increasing tumour radiosensitivity in animal models. Breathing 2.5% carbogen for 30 min results in a greater reduction in venous blood COHb levels than breathing 5% carbogen for 7 min.
Macdonald
Graham
G
Department of Radiation Oncology, Vancouver Cancer Centre, BC Cancer Agency, Vancouver, BC, Canada.
Kondor
Natalie
N
Yousefi
Vandad
V
Green
Alex
A
Wong
Frances
F
Aquino-Parsons
Christina
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002245:Carbon Dioxide / Q000008:administration & dosage* / Q000494:pharmacology*; D002263:Carboxyhemoglobin / Q000032:analysis* / Q000378:metabolism*; D015687:Cell Hypoxia; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy; D010100:Oxygen / Q000008:administration & dosage* / Q000494:pharmacology*; D011836:Radiation Tolerance; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D011878:Radiotherapy; D012907:Smoking / Q000009:adverse effects*
D011838:Radiation-Sensitizing Agents; D002245:Carbon Dioxide; C011700:carbogen; D002263:Carboxyhemoglobin; D010100:Oxygen