Pathogenesis of acute rheumatic fever and rheumatic heart disease: evasive after half a century of clinical, epidemiological, and laboratory investigation.
Rheumatic fever and rheumatic heart disease continue to be a problem for medical and public health communities--the fact that penicillin has failed to eradicate this disease process is irrefutable proof of the need for more laboratory, epidemiological, and clinical research.
Kaplan
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D000208:Acute Disease; D001327:Autoimmune Diseases / Q000209:etiology; D006349:Heart Valve Diseases / Q000209:etiology; D006801:Humans; D008943:Mitral Valve; D012213:Rheumatic Fever / Q000209:etiology*; D012214:Rheumatic Heart Disease / Q000209:etiology; D013297:Streptococcus pyogenes