title: The development of immunoglobulin-containing cell populations in intestine, spleen and mesenteric lymphnode of the young rat.
abstract: Immunohistological and immunochemical techniques were used to study the absorption, synthesis and secretion of immunoglobulins A, G and M in rats from 0-51 days of age. Intestinal epithelial cell-staining with IgA and IgG occurred during the first two weeks of the suckling period. Immunoglobulin G was detected in serum at all ages studied. IgA was first detected in animals aged one week, the levels rising gradually in succeeding weeks; there was a concomitant increase in the number of IgA-containing cells in the lamina propria of the intestine. No evidence was obtained to indicate the route of intestinal secretion of this class of immunoglobulin. Immunoglobulin M-containing cells were present in only small numbers.
authors.affiliation: Department of Veterinary Pathology, The University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH, Great Britain.
authors.forename: P J
authors.initials: PJ
authors.lastname: Brown
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D004847:Epithelial Cells / Q000276:immunology; D005260:Female; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis / Q000097:blood / Q000276:immunology*; D007421:Intestine, Small / Q000166:cytology / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D008297:Male; D051381:Rats / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology*
chemical_list: D007132:Immunoglobulin Isotypes