Determination of baclofen enantiomers in pharmaceutical formulations using maltodextrin-based enantioselective, potentiometric membrane electrodes.
Two enantioselective, potentiometric membrane electrodes (EPMEs) based on maltodextrins with different value of dextrose equivalent (DE) (maltodextrin I: DE 4.0-7.0; maltodextrin II: DE 16.5-19.5) were proposed for the assay of baclofen enantiomers in baclofen raw materials and from its pharmaceutical formulation, Norton-Baclofen tablets. The slopes of the electrode function of the proposed electrodes were 55.0 mV/pS-baclofen for maltodextrin I-based electrode and 59.0 mV/pR-baclofen for maltodextrin II-based electrode and the detection limits were 1.34 x 10(-6) mol l(-1) (S-baclofen) and 2.52 x 10(-10) mol l(-1) (R-baclofen), respectively. The surfaces of the electrodes are stable and easily renewable by simply polishing on alumina paper.
Rat'ko
Alexander A
AA
Department of Chemistry, University of Pretoria, Pretoria 0002, South Africa.
Stefan-van Staden
Raluca-Ioana
RI
D001418:Baclofen / Q000032:analysis* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004566:Electrodes; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D011134:Polysaccharides / Q000032:analysis* / Q000737:chemistry; D011199:Potentiometry / Q000379:methods; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations; D011134:Polysaccharides; C008315:maltodextrin; D001418:Baclofen