Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential.
BACKGROUND
Gene expression profiling of melanoma and nevic tissue has demonstrated that pleiotrophin (PTN) is significantly overexpressed in human melanomas.


METHODS
To further evaluate PTN expression in melanocytic lesions, protein immunohistochemistry was performed on the spectrum of melanocytic lesions.


RESULTS
Melanocytic nevi were consistently negative (n=58). In contrast, the great majority of metastatic melanomas were positive (33/34, 97%). The analysis of 34 primary melanomas demonstrated PTN positivity in 20 lesions while 14 lesions were negative. Within the primary melanomas, PTN immunoreactivity was associated with metastasis (p=0.0004) and decreased melanoma-related survival (p=0.0444). Univariate analysis of PTN immunoreactivity predicted an increased risk for metastasis (relative risk 9.1, p=0.003).


CONCLUSIONS
The results of this study confirm previous gene profiling data showing differential PTN expression between melanocytic nevi and melanomas. In addition, lesional PTN expression is associated with metastatic potential and may be a prognostic factor for melanomas.
Wu
H
H
Department of Pathology, Fox Chase Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Barusevicius
A
A
Babb
J
J
Klein-Szanto
A
A
Godwin
A
A
Elenitsas
R
R
Gelfand
J M
JM
Lessin
S
S
Seykora
J T
JT
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002352:Carrier Proteins / Q000096:biosynthesis*; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D009362:Neoplasm Metastasis / Q000473:pathology*; D009508:Nevus, Pigmented / Q000378:metabolism*; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis
D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D016207:Cytokines; C066845:pleiotrophin