TPMD: a database and resources of microsatellite marker genotyped in Taiwanese populations.
Taiwan Polymorphic Marker Database (TPMD) (http://tpmd.nhri.org.tw/) is a marker database designed to provide experimental details and useful marker information allelotyped in Taiwanese populations accompanied by resources and technical supports. The current version deposited more than 372,000 allelotyping data from 1425 frequently used and fluorescent-labeled microsatellite markers with variation types of dinucleotide, trinucleotide and tetranucleotide. TPMD contains text and map displays with searchable and retrievable options for marker names, chromosomal location in various human genome maps and marker heterozygosity in populations of Taiwanese, Japanese and Caucasian. The integration of marker information in map display is useful for the selection of high heterozygosity and commonly used microsatellite markers to refine mapping of diseases locus followed by identification of disease gene by positional candidate cloning. In addition, our results indicated that the number of markers with heterozygosity over 0.7 in Asian populations is lower than that in Caucasian. To increase accuracy and facilitate genetic studies using microsatellite markers, we also list markers with genotyping difficulty due to ambiguity of allele calling and recommend an optimal set of microsatellite markers for genotyping in Taiwanese, and possible extension of genotyping in other Mongoloid populations.
Chang
Ya-Hui
YH
Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 115, Taiwan.
Su
Wen-Hui
WH
Lee
Tso-Ching
TC
Sun
Hsiao-Fang Sunny
HF
Chen
Chia-Hsiang
CH
Pan
Wen-Harn
WH
Tsai
Shih-Feng
SF
Jou
Yuh-Shan
YS
D000483:Alleles; D044466:Asian People / Q000235:genetics; D002874:Chromosome Mapping; D030561:Databases, Nucleic Acid; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic; D013624:Taiwan
D005819:Genetic Markers