title: Significance of beta 2-toxigenic clostridium perfringens infections in animals and their predisposing factors--a review.
abstract: The novel beta 2-toxin of Clostridium perfringens has recently been described as the cause of enteric diseases in animals. The biological activity of beta 2-toxin is similar to that of the beta1-toxin with a possibly weaker cytotoxic activity. However, the production of beta 2-toxin in vitro is not seen in all beta 2-toxin-gene (cpb2)-positive C. perfringens strains, and to deduce a clinical importance solely from the detection of cpb2 is difficult. Detection of cpb2-positive C. perfringens from various animal species with and without enteric diseases demonstrates the wide distribution of cpb2 in nature, and the presence of cpb2 gene is therefore not considered a risk by itself. Predisposing factors like low trypsin activity in the intestinal tract, antibiotic and/or antiphlogistic treatment or changes in diet can result in the selection of beta 2-toxigenic C. perfringens which may lead to enteritis or enterotoxaemia.
authors.affiliation: Central Medical Service Institute of German Armed Forces Kiel, Division of Veterinary Medicine, Kopperpahler Allee 120, 24119 Kronshagen, Germany. u.schotte@t-online.de
authors.forename: U
authors.initials: U
authors.lastname: Schotte
authors.forename: U
authors.initials: U
authors.lastname: Truyen
authors.forename: H
authors.initials: H
authors.lastname: Neubauer
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000235:genetics; D003015:Clostridium Infections / Q000382:microbiology / Q000662:veterinary*; D003016:Clostridium perfringens / Q000235:genetics / Q000472:pathogenicity*; D004751:Enteritis / Q000382:microbiology / Q000662:veterinary*
chemical_list: D001427:Bacterial Toxins