Acremonium pyomyositis in a pediatric patient with acute leukemia.
Invasive Acremonium infection in humans is rare. We report a patient with leukemia who developed pyomyositis due to Acremonium species. Painful cutaneous nodules and severe myalgia were the first clinical manifestations during the neutropenic stage after chemotherapy. Magnetic resonance image (MRI) revealed multiple nodular lesions scattered along the intramuscular regions of the lower legs. Culture of an aspiration grew Acremonium species. Surgical drainage was performed. Although all antifungal agents tested showed no in vitro inhibitory activity, we successfully treated this patient with amphotericin B, granulocyte colony-stimulating factor (G-CSF), and surgical drainage.
Chang
Yu-Hsiang
YH
Department of Pediatrics, Veterans General Hospital-Kaohsiung, Kaohsiung, Taiwan.
Huang
Li-Min
LM
Hsueh
Po-Ren
PR
Hsiao
Cheng-Hsiang
CH
Peng
Shinn-Forng
SF
Yang
Rong-Sen
RS
Lin
Kai-Hsin
KH
D000164:Acremonium; D000208:Acute Disease; D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D004322:Drainage; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000150:complications*; D009181:Mycoses / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D009503:Neutropenia / Q000150:complications; D009894:Opportunistic Infections
D016179:Granulocyte Colony-Stimulating Factor; D000666:Amphotericin B