title: [Functional repair of a major necrotic palatine defect caused by chronic cocaine inhalation].
abstract: BACKGROUND
  Chronic use of cocaine provokes vasoconstriction and irritation of the upper airway epithelium. These mechanisms can lead to tissue necrosis and perforations.
  
  
  METHODS
  A 37-year-old woman had major centrofacial necrosis subsequent to chronic inhalation of cocaine. The tissue loss involved the right wing of the right ala nasi, the bony and soft palate and nearly all of the lateronasal walls. A microanastomosed antebrachial fasciocutaneous flap was used for reconstruction of the nasal vault. A classical veloplasty was used to close the palate. Velar competency was improved with a second procedure with Ortricochea sphincter pharyngoplasty. Later loss of the antebrachial flap required salvage with a flap from the lateral border of the tongue which provided a satisfactory functional result.
  
  
  CONCLUSIONS
  This case of extended necrosis is rare and treatment was complex. Such treatment can only be undertaken after total and definitive cessation of drug abuse, including tobacco smoking.
authors.affiliation: Service de chirurgie Maxillo-Faciale et Plastique, CHU de Charleroi, Boulevard Paul Janson, 92, 6000 Charleroi, Belgique.
authors.forename: T
authors.initials: T
authors.lastname: Ladner
authors.forename: M
authors.initials: M
authors.lastname: Linker
authors.forename: J
authors.initials: J
authors.lastname: Gitani
mesh_terms: D000328:Adult; D019970:Cocaine-Related Disorders / Q000150:complications*; D005205:Fascia / Q000637:transplantation; D005260:Female; D006801:Humans; D009296:Nasal Cavity / Q000473:pathology / Q000601:surgery; D009336:Necrosis; D009666:Nose / Q000473:pathology / Q000601:surgery; D021362:Palate, Hard / Q000473:pathology / Q000601:surgery*; D010160:Palate, Soft / Q000473:pathology / Q000601:surgery*; D016038:Skin Transplantation; D013524:Surgical Flaps