title: Development and validation of computational models of cellular interaction.
abstract: In this paper we take the view that computational models of biological systems should satisfy two conditions - they should be able to predict function at a systems biology level, and robust techniques of validation against biological models must be available. A modelling paradigm for developing a predictive computational model of cellular interaction is described, and methods of providing robust validation against biological models are explored, followed by a consideration of software issues.
authors.affiliation: Department of Computer Science, University of Sheffield, 211 Portobello Street, Sheffield, S1 4DP, UK.
authors.forename: R H
authors.initials: RH
authors.lastname: Smallwood
authors.forename: W M L
authors.initials: WM
authors.lastname: Holcombe
authors.forename: D C
authors.initials: DC
authors.lastname: Walker
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D004848:Epithelium / Q000502:physiology; D008954:Models, Biological; D012984:Software