Effect of antacids and ranitidine on the single-dose pharmacokinetics of fosamprenavir.
Single doses of MAALOX TC and ranitidine were administered separately with 1,400 mg of fosamprenavir (FPV). MAALOX TC decreased the area under the concentration-time curve from 0 to 24 h (AUC(0-24)) for plasma amprenavir (APV) by 18% and the maximum concentration of drug in serum (C(max)) by 35%; the plasma APV concentration at 12 h (C(12)) increased by 14%. Ranitidine at 300 mg decreased the AUC(0-24) for plasma APV by 30% and C(max) by 51%; C(12) was unchanged. FPV may be coadministered with antacids without concern and without separation in dosing; however, caution is recommended when FPV is coadministered with histamine(2)- receptor antagonists or proton pump inhibitors.
Ford
Susan L
SL
GlaxoSmithKline, 5 Moore Dr., Research Triangle Park, NC 27709, USA. susan.l.ford@gsk.com
Wire
Mary B
MB
Lou
Yu
Y
Baker
Katherine L
KL
Stein
Daniel S
DS
D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000494:pharmacology*; D000863:Antacids / Q000008:administration & dosage / Q000494:pharmacology*; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D019540:Area Under Curve; D002219:Carbamates; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004347:Drug Interactions; D005663:Furans; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008276:Magnesium Hydroxide / Q000008:administration & dosage / Q000494:pharmacology*; D010755:Organophosphates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011899:Ranitidine / Q000008:administration & dosage / Q000494:pharmacology*; D013449:Sulfonamides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000863:Antacids; D000897:Anti-Ulcer Agents; D002219:Carbamates; D004338:Drug Combinations; D005663:Furans; D017320:HIV Protease Inhibitors; D010755:Organophosphates; D013449:Sulfonamides; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; C095108:amprenavir; D011899:Ranitidine; D008276:Magnesium Hydroxide; C426859:fosamprenavir