title: Detection of gliotoxin in experimental and human aspergillosis.
abstract: Gliotoxin was measured in the lungs (mean, 3,976 +/- 1,662 ng/g of tissue) and sera (mean, 36.5 +/- 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.
authors.affiliation: University of Houston College of Pharmacy; 1441 Moursund St. #423, Houston, TX 77030, USA. rlewis@uh.edu
authors.forename: Russell E
authors.initials: RE
authors.lastname: Lewis
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Wiederhold
authors.forename: Jingduan
authors.initials: J
authors.lastname: Chi
authors.forename: Xiang Y
authors.initials: XY
authors.lastname: Han
authors.forename: Krishna V
authors.initials: KV
authors.lastname: Komanduri
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
authors.forename: Randall A
authors.initials: RA
authors.lastname: Prince
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005912:Gliotoxin / Q000032:analysis*; D006801:Humans; D008168:Lung / Q000737:chemistry; D051379:Mice
chemical_list: D005912:Gliotoxin; D000666:Amphotericin B