title: Dianion approach to chiral cyclopropene carboxylic acids.
abstract: [reaction: see text] In this Letter, we describe a general method for preparing the dianions of cyclopropene carboxylic acids, and we show that their subsequent reactions with electrophiles provide a general means for selectively introducing diverse types of functional groups. This provides a general method for the synthesis of chiral 1,2-disubstituted cyclopropenes, and opens new avenues for the enantioselective preparation of cyclopropenes.
authors.affiliation: Brown Laboratories, Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA.
authors.forename: Lian-an
authors.initials: LA
authors.lastname: Liao
authors.forename: Ni
authors.initials: N
authors.lastname: Yan
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Fox
mesh_terms: D000838:Anions / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D000838:Anions; D002264:Carboxylic Acids; D003521:Cyclopropanes; C021985:cyclopropene