title: Histopathological and enzyme histochemical observations on mast cells in pulmonary arterial lesion of dogs with Dirofilaria immitis infestation.
abstract: Histopathological and enzyme histochemical observations were performed on mast cells in pulmonary arterial lesion of Dirofilaria immitis in dogs. The results showed that chymase- and tryptase-positive mast cells were diffusely present in the lesions, especially in the adventitia and proliferated intima. At 2 weeks after surgical worm transplantation, mast cells already appeared in the intima and media, and chymase-positive cells were dominant in the adventitia. Results of this study suggested a possibility that mast cells would be involved in the pathogenesis of pulmonary arterial lesion of dogs with Dirofilaria immitis infestation.
authors.affiliation: Department of Veterinary Surgery, Faculty of Agriculture, University of Miyazaki, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hidaka
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Hagio
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Horii
authors.forename: Takayuki
authors.initials: T
authors.lastname: Murakami
authors.forename: Kiyokazu
authors.initials: K
authors.lastname: Naganobu
authors.forename: Toru
authors.initials: T
authors.lastname: Miyamoto
mesh_terms: D000818:Animals; D004184:Dirofilariasis / Q000276:immunology* / Q000473:pathology; D004283:Dog Diseases / Q000276:immunology* / Q000473:pathology; D004285:Dogs; D005260:Female; D006651:Histocytochemistry / Q000662:veterinary; D008297:Male; D008407:Mast Cells / Q000201:enzymology* / Q000473:pathology*; D011651:Pulmonary Artery / Q000276:immunology* / Q000473:pathology