title: Three novel single nucleotide polymorphisms in UGT1A9.
abstract: Three novel single nucleotide polymorphisms (SNPs) were found in the UDP-glucuronosyltransferase (UGT) 1A9 gene from 97 Japanese subjects (47 cancer patients and 50 cardiovascular disease patients). The detected SNPs were as follows: 1) SNP, MPJ6_U1A006; GENE NAME, UGT1A9; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-AATTCTCTTAGGG/TTTCTCAGATGCC-3'. 2) SNP, MPJ6_U1A007; GENE NAME, UGT1A9; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-TGTTACGGAGTAT/GGATCTCTACAGC-3'. 3) SNP, MPJ6_U1A031; GENE NAME, UGT1A9; ACCESSION NUMBER, AF297093; LENGTH, 25 bases; 5'-ACTCATTCTCAGG/AGGGCATGAGGTG-3'. All three SNPs were located in exon 1 with frequencies of 0.036 for MPJ6_U1A006, and 0.005 for MPJ6_U1A007 and MPJ6_U1A031. SNP MPJ6_U1A007 (726T>G) results in formation of a termination codon TAG (Y242X). The other two SNPs, MPJ6_U1A006 (588G>T) and MPJ6_U1A031 (153G>A), result in synonymous changes (G196G and R51R, respectively).
authors.affiliation: Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan.
authors.forename: Mayumi
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authors.lastname: Saeki
authors.forename: Yoshiro
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authors.forename: Hideto
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authors.lastname: Jinno
authors.forename: Kimie
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authors.lastname: Sai
authors.forename: Kazuo
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authors.lastname: Komamura
authors.forename: Kazuyuki
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authors.lastname: Kamakura
authors.forename: Masafumi
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authors.lastname: Kitakaze
authors.forename: Kuniaki
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authors.forename: Hironobu
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authors.lastname: Minami
authors.forename: Atsushi
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authors.lastname: Ohtsu
authors.forename: Teruhiko
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authors.lastname: Yoshida
authors.forename: Nagahiro
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authors.lastname: Saijo
authors.forename: Shogo
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authors.lastname: Ozawa
authors.forename: Jun-ichi
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authors.lastname: Sawada