[Anti-enterovirus and immunostimulating activity of the polyphenol complex extracted from Pethaphylloides fruticosa (L.) O. Schwarz].
Studied within the present case study was the antiviral and viricidal activity of the water-soluble polyphenol complex, obtained from Penthaphylloides fruticosa (L.) O. Schwarz, in respect to Enteroviruses Coxsackie B. The complex had a low toxicity and high chemotherapeutic index when introduced experimentally in the cell culture. The therapeutic effect of the water-soluble extract was detected in an experimental infection of newborn mice caused by Coxsackievirus B3. The interferongenic and immunostimulating action of the drug were demonstrated. The results obtained are in favor of further research of the extract as of a promising antiviral drug.
Evstropov
A N
AN
Burova
L G
LG
Orlovskaia
I A
IA
Grek
O R
OR
Zakharova
L N
LN
Volkhonskaia
T A
TA
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000831:Animals, Newborn; D021461:Animals, Outbred Strains; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000276:immunology; D002460:Cell Line / Q000187:drug effects; D029822:Enterovirus B, Human / Q000187:drug effects* / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D005260:Female; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D006801:Humans; D007372:Interferons / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D059808:Polyphenols; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D007372:Interferons