title: EEG coherence reflects regional corpus callosum area in Alzheimer's disease.
abstract: OBJECTIVE
  Correlations between corpus callosum size and interhemispheric EEG coherence were investigated as measures of interhemispheric connectivity in patients with Alzheimer's disease.
  
  
  METHODS
  11 patients underwent both magnetic resonance imaging and quantitative electroencephalography to assess corpus callosum size and interhemispheric coherence. For comparison, corpus callosum size was measured in 24 healthy elderly control subjects.
  
  
  RESULTS
  Corpus callosum cross sectional area was significantly reduced in Alzheimer patients relative to controls. Posterior interhemispheric coherence (alpha and beta frequencies) correlated significantly with the size of posterior corpus callosum area, and anterior coherence (delta, theta, and alpha frequencies) with the size of anterior corpus callosum area in the Alzheimer patients.
  
  
  CONCLUSIONS
  Region specific correlations between corpus callosum size and EEG coherence suggest that the decline in interhemispheric connectivity in Alzheimer's disease results from a specific loss of cortical association neurones projecting through the corpus callosum.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilians-University of Munich, Nussbaumstrasse 7, D-80336 Munich, Germany. oliver.pogarell@med.uni-muenchen.de
authors.forename: O
authors.initials: O
authors.lastname: Pogarell
authors.forename: S J
authors.initials: SJ
authors.lastname: Teipel
authors.forename: G
authors.initials: G
authors.lastname: Juckel
authors.forename: L
authors.initials: L
authors.lastname: Gootjes
authors.forename: T
authors.initials: T
authors.lastname: Möller
authors.forename: K
authors.initials: K
authors.lastname: Bürger
authors.forename: G
authors.initials: G
authors.lastname: Leinsinger
authors.forename: H-J
authors.initials: HJ
authors.lastname: Möller
authors.forename: U
authors.initials: U
authors.lastname: Hegerl
authors.forename: H
authors.initials: H
authors.lastname: Hampel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology*; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000473:pathology* / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size