title: Hemolytic effects of water-soluble fullerene derivatives.
abstract: A series of water-soluble fullerene C(60) derivatives has been investigated for their cytotoxic and hemolytic properties, with the aim to correlate structure with toxicity. We observed that cationic chains induce significant toxicity while the presence of neutral or anionic moieties did not produce any response in our model. A validation of these experimental observations has been performed by theoretical studies in which hydrophilic and hydrophobic surface areas were correlated quantitatively with hemolytic properties.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa, 1-34127 Trieste, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Bosi
authors.forename: Luigi
authors.initials: L
authors.lastname: Feruglio
authors.forename: Tatiana
authors.initials: T
authors.lastname: Da Ros
authors.forename: Giampiero
authors.initials: G
authors.lastname: Spalluto
authors.forename: Barbara
authors.initials: B
authors.lastname: Gregoretti
authors.forename: Michela
authors.initials: M
authors.lastname: Terdoslavich
authors.forename: Giuliana
authors.initials: G
authors.lastname: Decorti
authors.forename: Sabina
authors.initials: S
authors.lastname: Passamonti
authors.forename: Stefano
authors.initials: S
authors.lastname: Moro
authors.forename: Maurizio
authors.initials: M
authors.lastname: Prato
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D037741:Fullerenes / Q000737:chemistry / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D012995:Solubility
chemical_list: D037741:Fullerenes; C069837:fullerene C60