title: A rare case of bilateral stage IV adrenal neuroblastoma with multiple skin metastases in a neonate: diagnosis, management, and outcome.
abstract: A neonate with stage IV bilateral adrenal neuroblastoma associated with metastases to the skin, liver, bone marrow, and right ocular conjunctiva is reported. At birth, skin metastases were present all over the body. He underwent a combination of chemotherapy, surgery, and peripheral blood stem cell transplantation (PBSCT). Histopathology was unfavorable with diploid tumor cell DNA content and low levels of TRK-A mRNA expression. Skin and conjunctival metastases disappeared after PBSCT, and there have been no signs of recurrence after 5 years of follow-up. Accurate staging of disease and histologic examination followed by intensive management are essential even in infants with neuroblastoma to ensure successful outcome.
authors.affiliation: Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Yanai
authors.forename: Tadaharu
authors.initials: T
authors.lastname: Okazaki
authors.forename: Atsuyuki
authors.initials: A
authors.lastname: Yamataka
authors.forename: Hiroo
authors.initials: H
authors.lastname: Fujita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Saito
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Lane
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamashiro
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miyano
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009447:Neuroblastoma / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D012878:Skin Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy