Toxic epidermal necrolysis as a complication of treatment with voriconazole.
An 81-year-old female received voriconazole in a 7-day treatment course for a symptomatic Candida krusei urinary tract infection. Four days after the last dose, she developed toxic epidermal necrolysis. She was treated with intravenous immunoglobulin, and her symptoms promptly resolved.
Huang
David B
DB
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. dhuang1@bcm.tmc.edu
Wu
Jashin J
JJ
Lahart
Christopher J
CJ
D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D011743:Pyrimidines / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D014230:Triazoles / Q000009:adverse effects*; D065819:Voriconazole
D000935:Antifungal Agents; D016756:Immunoglobulins, Intravenous; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole