Signaling circuitries in development: insights from the retinal determination gene network.
Context-specific integration of information received from the Notch, Transforming growth factor beta, Wingless/Wnt, Hedgehog and Epidermal growth factor receptor signaling pathways sets the stage for deployment of the retinal determination gene network (RDGN), a group of transcription factors that collectively directs the formation of the eye and other tissues. Recent investigations have revealed how these transcription factors are regulated by their interactions with each other and with effectors of the above signaling pathways. Further study of the RDGN may provide insights into how common cues can generate context-specific responses, a key aspect of developmental regulation that remains poorly understood.
Silver
Serena J
SJ
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Rebay
Ilaria
I
D000818:Animals; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D005786:Gene Expression Regulation; D053823:Hedgehog Proteins; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008954:Models, Biological; D010641:Phenotype; D017956:Photoreceptor Cells, Invertebrate / Q000196:embryology; D012160:Retina / Q000502:physiology*; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism; D051153:Wnt Proteins
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D036341:Intercellular Signaling Peptides and Proteins; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D051153:Wnt Proteins; C077245:hh protein, Drosophila; D066246:ErbB Receptors