Topical application of ionic polymers affects skin permeability barrier homeostasis.
We previously demonstrated that the external electric potential affected skin barrier homeostasis. On the other hand, topical application of an ionic polymer formed a diffusion electric double layer on the surface of the skin. Thus, we evaluated effects of topical application of ionic polymers on the damaged skin barrier. Application of a nonionic polymer did not affect barrier recovery. Application of sodium salts of anionic polymers accelerated barrier recovery, while that of cationic polymers delayed it. Topical application of a sodium-exchange resin accelerated barrier recovery, but application of a calcium-exchange resin had no effect even when the resins had the same structure. Application of a chloride-exchange resin delayed barrier recovery. Topical application of ionic polymers influenced skin barrier homeostasis.
Denda
M
M
Shiseido Research Center, 2-12-1 Fukuura, Kanazawa-ku, Yokohama, 236-8643, Japan. mitsuhiro.denda@to.shiseido.co.jp
Nakanishi
K
K
Kumazawa
N
N
D000279:Administration, Cutaneous; D000818:Animals; D000838:Anions / Q000493:pharmacokinetics; D002412:Cations / Q000493:pharmacokinetics; D002480:Cellulase / Q000493:pharmacokinetics; D048271:Chitosan / Q000493:pharmacokinetics; D002809:Chondroitin Sulfates / Q000493:pharmacokinetics; D004594:Electrophysiology; D004817:Epidermis / Q000502:physiology; D006493:Heparin / Q000493:pharmacokinetics; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D011095:Polyethylenes / Q000493:pharmacokinetics; D011108:Polymers / Q000493:pharmacokinetics*; D011142:Polyvinyl Alcohol / Q000493:pharmacokinetics; D000644:Quaternary Ammonium Compounds / Q000493:pharmacokinetics; D012869:Skin Absorption / Q000187:drug effects* / Q000502:physiology
D000838:Anions; D002412:Cations; D011095:Polyethylenes; D011108:Polymers; D000644:Quaternary Ammonium Compounds; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; D011142:Polyvinyl Alcohol; D006493:Heparin; D002809:Chondroitin Sulfates; D048271:Chitosan; D002480:Cellulase; C019826:carboxymethylcellulase