title: [Evaluation of in vitro/in vivo correlation for three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method].
abstract: OBJECTIVE
  To evaluate the in vitro/in vivo correlation for three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method.
  
  
  METHODS
  The characteristics of in vivo release were calculated by deconvolution method using the data of plasma concentration of three kinds of self-designed sustained-release nitrendipine formulations in healthy dogs, in which the in vivo results of nitrendipine solution after oral administrated to dogs were used as weight function. It was the compared with characteristics of in vitro release to assess the in vitro/in vivo correlations.
  
  
  RESULTS
  The good correlations of in vitro/in vivo were shown in three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method.
  
  
  CONCLUSIONS
  The deconvolution method exhibited advantage in evaluation of in vitro/in vivo correlation for self-designed sustained-release nitrendipine formulations.
authors.affiliation: Department of Pharmaceutics, School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Ming-shi
authors.initials: MS
authors.lastname: Yang
authors.forename: Ben-gang
authors.initials: BG
authors.lastname: You
authors.forename: Ming-hua
authors.initials: MH
authors.lastname: Yang
authors.forename: Dong-mei
authors.initials: DM
authors.lastname: Cun
authors.forename: An-jin
authors.initials: AJ
authors.lastname: Tao
authors.forename: Fu-de
authors.initials: FD
authors.lastname: Cui
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003692:Delayed-Action Preparations; D004285:Dogs; D008747:Methylcellulose / Q000031:analogs & derivatives*; D008863:Microspheres; D009568:Nitrendipine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011208:Powders; D020034:Silicone Gels; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D003692:Delayed-Action Preparations; D011208:Powders; D020034:Silicone Gels; D008747:Methylcellulose; C053309:hydroxypropyl methylcellulose phthalate; D009568:Nitrendipine