title: Older rhesus macaque infants are more susceptible to oral infection with simian-human immunodeficiency virus 89.6P than neonates.
abstract: Earlier primate studies revealed that oral transmission of immunodeficiency viruses can occur at all ages [R. M. Ruprecht et al., J. Infect. Dis. 179(Suppl. 3):S408-S412, 1999]. Using a stock of pathogenic simian-human immunodeficiency virus, SHIV89.6P, we compared the 50% animal infectious dose needed to achieve systemic infection after oral challenge in newborn and older infant or juvenile rhesus macaques. Unexpectedly, the older monkeys required a 150-fold-lower virus challenge dose than the neonates (P=3.3 x 10(-5)). In addition, at least 60,000 times more virus was needed to achieve systemic infection in neonates by the oral route than by the intravenous route (P <1 x 10(-5)). Thus, route of inoculation and age are important determinants of SHIV89.6P infectivity in rhesus macaques.
authors.affiliation: Department of Cancer Immunology, Dana-Farber Cancer Institute, 44 Binney Street, JFB809, Boston, MA 02115-6084, USA.
authors.forename: Agnès-Laurence
authors.initials: AL
authors.lastname: Chenine
authors.forename: Flavia
authors.initials: F
authors.lastname: Ferrantelli
authors.forename: Regina
authors.initials: R
authors.lastname: Hofmann-Lehmann
authors.forename: Mark G
authors.initials: MG
authors.lastname: Vangel
authors.forename: Harold M
authors.initials: HM
authors.lastname: McClure
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Ruprecht
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D008253:Macaca mulatta / Q000821:virology*; D019713:Receptors, CCR5 / Q000502:physiology; D019718:Receptors, CXCR4 / Q000502:physiology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000209:etiology* / Q000821:virology; D019562:Viral Load
chemical_list: D019713:Receptors, CCR5; D019718:Receptors, CXCR4