title: A single dose of erythropoietin attenuates lipid peroxidation in experimental liver ischemia-reperfusion injury in the rat fetus.
abstract: OBJECTIVE
  The aim of the study was investigate the effectiveness of recombinant human erythropoietin (r-Hu-EPO) in attenuating the severity of experimental liver ischemic injury in fetal rats.
  
  
  METHODS
  The animals were divided randomly into four groups. In the control group, fetal whole liver tissue was taken immediately after laparotomy from pregnant animals. In the ischemia-reperfusion (I/R) group, tissue samples were taken immediately after I/R injury. In the vehicle group, 0.4 ml of human serum albumin solution and in the treatment group, r-Hu-EPO (5000 IU/kg) in 0.4 ml of human serum albumin solution were given intraperitoneally, 30 min before I/R injury, as a single dose. Thiobarbituric acid-reactive substances (TBARS) were estimated to demonstrate lipid peroxidation.
  
  
  RESULTS
  Lipid peroxidation byproducts increased after I/R injury. Administration of r-Hu-EPO reduced TBARS after I/R injury.
  
  
  CONCLUSIONS
  Further investigations are needed to understand the mechanism of the hepatoprotective effect of erythropoietin and the clinical importance of ischemic liver injury in the fetus.
authors.affiliation: Social Insurance Institution, Ankara Maternity and Women's Health Teaching Hospital, Department of Obstetrics and Gynecology, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Solaroglu
authors.forename: F S
authors.initials: FS
authors.lastname: Dede
authors.forename: E
authors.initials: E
authors.lastname: Okutan
authors.forename: A
authors.initials: A
authors.lastname: Bayrak
authors.forename: A
authors.initials: A
authors.lastname: Haberal
authors.forename: K
authors.initials: K
authors.lastname: Kilinc
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D004921:Erythropoietin / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000098:blood supply*; D006801:Humans; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000098:blood supply / Q000196:embryology*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D015427:Reperfusion Injury / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D011994:Recombinant Proteins; D017392:Thiobarbituric Acid Reactive Substances; D004921:Erythropoietin