Relationship between cerebral injury and inflammatory responses in patients undergoing cardiac surgery with cardiopulmonary bypass.
This study was performed to evaluate whether cytokines, adhesion molecules, ghrelin and S-100B are useful markers in predicting the cerebral infarction after cardiac surgery with cardioplumomary bypass (CPB). The patients (n=20) were classified into two groups; group A (n=4) showed postoperative organized cerebral damage, while group B (n=16) consisted of patients without occurrence of postoperative strokes. Before CPB, serum levels of S-100B in both groups A and B were low (<0.5 ng/mL), while ghrelin concentrations in group A (all patients had history of strokes) were much higher than those in group B. After CPB, when serum levels of S-100B in group A at 24h were higher than those in group B, ghrelin in group A at same time point showed high levels in comparison to group B. At 12 and 24h after CPB, levels of tumor necrosis factor (TNF)-alpha, interleukin-10 and soluble TNF-receptor I in group A were significantly higher than those in group B. In conclusion, it is considered that ghrelin as well as S-100B can be a useful marker for the prediction of stoke after CPB. Increase of TNF-alpha, interleukin-10 and soluble TNF-receptor I after CPB may be involved in the pathogenesis of stroke after CPB.
Nakamura
Kazuo
K
Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. nakamura@m3.kufm.kagoshima-u.ac.jp
Ueno
Takayuki
T
Yamamoto
Hiroyuki
H
Iguro
Yoshifumi
Y
Yamada
Katsushi
K
Sakata
Ryuzo
R
D000368:Aged; D015415:Biomarkers; D002315:Cardiopulmonary Bypass; D002544:Cerebral Infarction; D016207:Cytokines / Q000097:blood; D019040:E-Selectin / Q000097:blood; D005260:Female; D054439:Ghrelin; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D009414:Nerve Growth Factors; D019007:P-Selectin / Q000097:blood; D036361:Peptide Hormones / Q000097:blood; D012307:Risk Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood
D015415:Biomarkers; D016207:Cytokines; D019040:E-Selectin; D054439:Ghrelin; D009414:Nerve Growth Factors; D019007:P-Selectin; D036361:Peptide Hormones; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins