Poly(lactide-co-glycolide) microparticles as systems for controlled release of proteins -- preparation and characterization.
Poly(DL-lactide-co-glycolide) (PDLLGA) and poly(L-lactide-co-glycolide) (PLLGA) copolymers were prepared by bulk ring opening polymerization of lactide and glycolide and characterized by GPC, FTIR, 1H NMR and DSC. Copolymers with different molar masses at a constant lactide/glycolide ratio were used for preparation of bovine serum albumin (BSA)-loaded microparticles by the double emulsion w/o/w method. The influence of the copolymer molar mass and composition on the microparticle morphology, size, yield, degradation rate, BSA-loading efficiency and BSA release profile were studied. For microparticles prepared from PDLLGA copolymers, a biphasic profile for BSA release was found and for those made from PLLGA copolymers the release profile was typically triphasic; both of them were characterized by high initial burst release. Possible reasons for such behavior are discussed.
Porjazoska
Aleksandra
A
Institute of Organic Technology, Faculty of Technology and Metallurgy, University Ss Cyril and Methodius, Skopje, R. Macedonia.
Goracinova
Katerina
K
Mladenovska
Kristina
K
Glavas
Marija
M
Simonovska
Maja
M
Janjević
Emilija Ivanovska
EI
Cvetkovska
Maja
M
D000818:Animals; D002417:Cattle; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000493:pharmacokinetics; D004655:Emulsions; D006016:Glycolates / Q000138:chemical synthesis / Q000493:pharmacokinetics; D019344:Lactic Acid / Q000138:chemical synthesis* / Q000145:classification / Q000493:pharmacokinetics*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000138:chemical synthesis* / Q000145:classification / Q000493:pharmacokinetics*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000138:chemical synthesis* / Q000145:classification / Q000493:pharmacokinetics*; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000493:pharmacokinetics; D013678:Technology, Pharmaceutical / Q000379:methods
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004655:Emulsions; D006016:Glycolates; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D012710:Serum Albumin, Bovine; D019344:Lactic Acid