title: Computed-tomography-guided percutaneous core needle biopsies of suspected malignant lymphomas: impact of biopsy, lesion, and patient parameters on diagnostic yield.
abstract: OBJECTIVE
  To investigate the diagnostic yield of core needle biopsy in patients with malignant lymphoma.
  
  
  METHODS
  Computed-tomography-guided core needle biopsies in patients with malignant lymphoma performed in the period 1996 to 2001 were evaluated retrospectively. A biopsy was considered as "fully diagnostic" if a histological diagnosis, including the histologic subtype in the event of malignant lymphoma, was achieved and the clinical course and CT follow-up of at least 6 months confirmed the biopsy results. A biopsy was regarded as "partly diagnostic" if histological work-up defined malignant lymphoma but not the histological subtype, and if histological diagnosis bore therapeutic relevance. Diagnostic yield was correlated with features such as size of specimen, location and depth of the target lesion, and experience of the investigator.
  
  
  RESULTS
  45 biopsies were performed in 40 patients. With respect to definite histopathological diagnosis, 31 biopsies (68.9%) were diagnostic and 14 (31.1%) non-diagnostic. In 4 cases (8.8%), biopsies yielded partly diagnostic results, since therapy could be scheduled after biopsy without final sub-classification. Statistical analysis of biopsy parameters revealed that sample sizes were significantly larger in the diagnostic group.
  
  
  CONCLUSIONS
  CT-guided biopsy can be considered as an alternative for lymphoma diagnosis and should be the first interventional procedure. The most important parameter for diagnostic success is the size of the specimen.
authors.affiliation: Department of Radiology, University of Cologne, Köln, Germany. Volker.Hesselmann@uni-koeln.de
authors.forename: V
authors.initials: V
authors.lastname: Hesselmann
authors.forename: M
authors.initials: M
authors.lastname: Zähringer
authors.forename: B
authors.initials: B
authors.lastname: Krug
authors.forename: C
authors.initials: C
authors.lastname: Wesselmann
authors.forename: K
authors.initials: K
authors.lastname: Haferkamp
authors.forename: C
authors.initials: C
authors.lastname: Wickenhauser
authors.forename: K
authors.initials: K
authors.lastname: Lackner
mesh_terms: D001707:Biopsy, Needle / Q000379:methods*; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed