title: Results of a phase I study to dose escalate using intensity modulated radiotherapy guided by combined PET/CT imaging with induction chemotherapy for patients with non-small cell lung cancer.
abstract: Intensity modulated radiation therapy (IMRT) guided by PET/CT imaging with respiratory gating was employed to dose escalate in patients with non-small cell lung cancer (NSCLC), using accelerated fractionation with induction chemotherapies. One patient developed a grade 5 pneumonitis and the study was halted at 84 Gy in 35 fractions.
authors.affiliation: Department of Radiation Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alta., Canada T6G 1Z2.
authors.forename: Caroline L
authors.initials: CL
authors.lastname: Holloway
authors.forename: Don
authors.initials: D
authors.lastname: Robinson
authors.forename: Brad
authors.initials: B
authors.lastname: Murray
authors.forename: John
authors.initials: J
authors.lastname: Amanie
authors.forename: Charles
authors.initials: C
authors.lastname: Butts
authors.forename: Michael
authors.initials: M
authors.lastname: Smylie
authors.forename: Karen
authors.initials: K
authors.lastname: Chu
authors.forename: A J
authors.initials: AJ
authors.lastname: McEwan
authors.forename: Ross
authors.initials: R
authors.lastname: Halperin
authors.forename: Wilson H
authors.initials: WH
authors.lastname: Roa
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D017564:Radiation Pneumonitis; D014057:Tomography, X-Ray Computed