Anaphylactoid response to Optison(R) and its effects on pulmonary function in two dogs.
Two of 26 anesthetized dogs given the cardiac echo-enhancing agent Optison showed anaphylactoid responses (AR) related to the human albumin component of this agent. The episodes of AR were self-limited, and could be reproduced by human albumin injection alone. Gas exchange was maintained by mechanical ventilation and 5 cm H(2)O PEEP, and dispersion of ventilation remained normal during AR despite severe hypotension. We suggest that: (1) pre-screening by measuring blood pressure response to intravenous injection of small doses of Optison, and (2) availability of access to the airway in addition to emergency agents may be prudent preventive measures when Optison is used in animals to enhance echocardiographic imaging.
Yamaya
Yoshiki
Y
Division of Physiology, Department of Medicine, University of California, USA.
Niizeki
Kyuichi
K
Kim
Jeannie
J
Entin
Pauline
P
Wagner
Harrieth
H
Wagner
Peter D
PD
D000418:Albumins / Q000009:adverse effects*; D000707:Anaphylaxis / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D004283:Dog Diseases / Q000139:chemically induced* / Q000503:physiopathology; D004285:Dogs; D005466:Fluorocarbons / Q000009:adverse effects*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D000418:Albumins; D003287:Contrast Media; C099458:FS 069; D005466:Fluorocarbons