Stilbene derivatives with antifungal and radical scavenging properties from the stem bark of Artocarpus nobilis.
Antifungal activity-guided fractionation of the n-butanol extract from the methanol extract of the stem bark of Artocarpus nobilis furnished two stilbene derivatives (E)-4-isopentenyl-3,5,2',4'-tetrahydroxystilbene and (E)-4-(3-methyl-E-but-1-enyl)-3,5,2',4'-tetrahydroxystilbene. Both compounds showed strong antifungal activity against Cladosporium cladosporioides and high radical scavenging activity towards the DPPH radical in TLC bio-autography method.
Jayasinghe
U L B
UL
Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka. lalith@ifs.ac.lk
Puvanendran
S
S
Hara
N
N
Fujimoto
Y
Y
D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031622:Artocarpus; D001713:Biphenyl Compounds; D002963:Cladosporium / Q000187:drug effects*; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D000935:Antifungal Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D013267:Stilbenes; C004931:1,1-diphenyl-2-picrylhydrazyl