title: Age-related increase of pulse pressure and plasminogen activator inhibitor-1 I/D gene polymorphism in essential hypertension.
abstract: BACKGROUND
  Pulse pressure (PP), a marker of cyclic strain on the arterial wall, is a significant predictor of cardiovascular (CV) risk, particularly regarding the incidence of coronary arterial stenosis. Genes related to haemostatic and/or fibrinolytic factors are consistently influenced in vitro by mechanical strain.
  
  
  OBJECTIVE
  The goal of the present study was to determine, in the three genotypes of the plasminogen activator inhibitor (PAI)-1 gene polymorphism, the gender-adjusted difference in the relationships between age and PP in subjects with never treated essential hypertension.
  
  
  RESULTS
  In the studied population, the genotype deletion (D)/D at position -675 of the PAI-1 insertion (I)/D gene polymorphism was associated with a significant increase in the adjusted slope of the curve relating age to PP by comparison with the two other genotypes. No comparable difference in age-related changes in systolic, diastolic or mean blood pressure was found.
  
  
  CONCLUSIONS
  In subjects with essential hypertension, the PAI-1 I/D gene polymorphism modulates the age-mediated increase of PP, suggesting new insights on the complex interactions between genes, mechanical factors and CV risk.
authors.affiliation: Department of Internal Medicine, Avicenne Hospital-AP-HP, Bobigny, France.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Mourad
authors.forename: G
authors.initials: G
authors.lastname: du Cailar
authors.forename: E-M
authors.initials: EM
authors.lastname: Nazal
authors.forename: M E
authors.initials: ME
authors.lastname: Safar
authors.forename: A
authors.initials: A
authors.lastname: Mimran
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D017395:Plasminogen Activator Inhibitor 1