title: Acquired macroglossia due to lopinavir/ritonavir treatment.
abstract: A HIV-positive patient, 3 months after the treatment initiation with lopinavir-/ritonavir (LPV/r) acquired macroglossia. The tongue biopsy revealed mature adipose tissue accumulated into submucosa. The drug was discontinued and the patient showed a significant improvement. This case is the first case in the medical literature of acquired macroglossia because of LPV/r, a drug causing changes in body fat composition.
authors.affiliation: Specific Infectious Disease Unit, AHEPA General Hospital of Thessaloniki, Thessaloniki, Greece.
authors.forename: Eleni
authors.initials: E
authors.lastname: Vritsali
authors.forename: Alexandros
authors.initials: A
authors.lastname: Kolokotronis
authors.forename: Despina
authors.initials: D
authors.lastname: Valagouti
authors.forename: Georgios
authors.initials: G
authors.lastname: Miteloudis
authors.forename: Thomas
authors.initials: T
authors.lastname: Zaraboukas
authors.forename: Vassilios
authors.initials: V
authors.lastname: Kioses
authors.forename: Demetrios
authors.initials: D
authors.lastname: Antoniades
mesh_terms: D000368:Aged; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D061466:Lopinavir; D008260:Macroglossia / Q000139:chemically induced* / Q000473:pathology; D011744:Pyrimidinones / Q000009:adverse effects* / Q000627:therapeutic use; D019438:Ritonavir / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D061466:Lopinavir; D019438:Ritonavir