title: [Study of serum levels of interlukin-2 and its receptor, interlukin-6, sICAM-1, sVCAM-1 in patients with recurrent genital herpes].
abstract: OBJECTIVE
  To study cellular immunity status and serum levels of adhesion molecules of patients with recurrent genital herpes.
  
  
  METHODS
  Serum levels of interlukin-2 and its soluble receptor, interlukin-6, sICAM-1, sVCAM-1 were measured by ELISA in 34 patients with recurrent genital herpes.
  
  
  RESULTS
  The serum levels of IL-2 and IL-6 were significantly lower in patients than in healthy controls (P < 0.01). The levels of sIL-2R, sICAM-1 and sVCAM-1 were significantly higher in patients than in controls (P < 0.05). No significant differences were seen in all variables of patients in relapse phase and remission phase (P > 0.05).
  
  
  CONCLUSIONS
  There are cellular immunity deficiency and high serum levels of adhesion molecules in patients with recurrent genital herpes, and these changes may be related to therecurrence of genital herpes and the development of inflammatory reaction.
authors.affiliation: Department of Dermatovenerology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Yizhi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D005260:Female; D006558:Herpes Genitalis / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood; D012008:Recurrence; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D007376:Interleukin-2; D015850:Interleukin-6; D015375:Receptors, Interleukin-2; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1