Large cell variant of small cell carcinoma, hypercalcemic type, of primary peritoneal origin.
BACKGROUND
Large cell variant of small cell carcinoma hypercalcemic type (SCC-HT) is extremely rare. All reported cases involved an ovary, and one with primary peritoneal origin has not been described. Also, convincing neuroendocrine granules have not been illustrated.


METHODS
A 35-year-old woman underwent an exploratory laparotomy for leiomyomas. Intraoperative impression of peritoneal carcinomatosis was confirmed on frozen section. TAH/BSO, debulking/omentectomy followed. The tumor was present on the pelvic/abdominal peritoneum. The normal-sized ovaries were free of tumor grossly. The tumor had features of large cell variant of SCC-HT, described in the ovary. Furthermore, unequivocal neuroendocrine granules were present. The patient received standard chemotherapy for SCC. At 22 months she is NED.


CONCLUSIONS
SCC-HT should be considered in the differential diagnosis of primary neoplasms of the peritoneum.
Popiolek
Dorota A
DA
Department of Pathology, 4W35B, New York University School of Medicine, Belluvue Hospital, 462 First Avenue, New York, NY 10016, USA. dorota.popiolek@med.nyu.edu
Kumar
Asok R
AR
Mittal
Khush
K
D000328:Adult; D018288:Carcinoma, Small Cell / Q000097:blood / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure