A patient with concurrent primary hyperaldosteronism and adrenal insufficiency.
A 73-year-old man with history of longstanding primary hyperaldosteronism developed adrenal insufficiency after he ruptured an abdominal aortic aneurysm and had a prolonged hypotensive episode. The patient presented as a diagnostic dilemma with recurrent hypotensive episodes and hypokalemia. A cosyntropin (Cortrosyn) stimulation test demonstrated a blunted cortisol response while at the same time having a suppressed plasma renin activity level and an elevated plasma aldosterone value. Diagnosis of Addison disease and concurrent primary hyperaldosteronism resulted in the patient's being treated with an unusual combination of prednisone and spironolactone followed by marked improvement in his symptoms.
Puentes
Francisco
F
Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA.
Jackson
Thomas W
TW
Isales
Carlos M
CM
D000309:Adrenal Insufficiency / Q000150:complications* / Q000188:drug therapy; D000368:Aged; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000188:drug therapy; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D011188:Potassium / Q000627:therapeutic use; D013148:Spironolactone / Q000627:therapeutic use
D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D011188:Potassium