title: Evaluation of the mixing effectiveness of a new powder mixer.
abstract: The effectiveness of the new powder mixer Canguro J tumbler was evaluated using lactose, microcrystalline cellulose, and salicylic acid as chemical indicator with the ratio 88:10:2 (w/w). The mixing time, the speed of the tumbler (rpm), its inclination, and filling percentage were varied in order to assess the limits of the mixer and the best parameters to use for obtaining a mixture as uniform as possible. The same experiments were then repeated after addition of 1% (w/w) magnesium stearate to the mixture of powders. The efficiency in the distribution of this lubricant was estimated by the progressive hardness reduction of the tablets derived from the compression of the powders, at a constant applied force. Finally, a comparison between Canguro J and a very efficient V-shaped mixer of the same capacity was performed. The results show that all investigated parameters influenced the mixing capability of Canguro J. The best effectiveness of the mixer occurred at the filling rate of 50% and a rotation speed of 20 rpm; in this case, Canguro J is even a little more effective than the V-shaped mixer. However, even at the filling rate of 70%, the same distribution uniformity of the powders can be obtained after a mixing time protraction of a few minutes.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Camerino, Via S. Agostino 1, 62032 Camerino (MC), Italy.
authors.forename: G F
authors.initials: GF
authors.lastname: Palmieri
authors.forename: D
authors.initials: D
authors.lastname: Lovato
authors.forename: L
authors.initials: L
authors.lastname: Marchitto
authors.forename: A
authors.initials: A
authors.lastname: Zanchetta
authors.forename: S
authors.initials: S
authors.lastname: Martelli
mesh_terms: D002482:Cellulose / Q000737:chemistry; D004339:Drug Compounding / Q000295:instrumentation* / Q000379:methods; D005079:Excipients / Q000737:chemistry; D006244:Hardness; D007785:Lactose / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D011208:Powders / Q000737:chemistry*; D011786:Quality Control; D020156:Salicylic Acid / Q000737:chemistry; D013229:Stearic Acids / Q000737:chemistry; D013997:Time Factors
chemical_list: D005079:Excipients; D011208:Powders; D013229:Stearic Acids; C031183:stearic acid; D002482:Cellulose; D007785:Lactose; D020156:Salicylic Acid; C109691:microcrystalline cellulose