title: Calcium and mitochondria: mechanisms and functions of a troubled relationship.
abstract: Mitochondria promptly respond to Ca(2+)-mediated cell stimulations with a rapid accumulation of the cation into the matrix. In this article, we review (i) the basic principles of mitochondrial Ca(2+) transport, (ii) the physiological/pathological role of mitochondrial Ca(2+) uptake, (iii) the regulatory mechanisms that may operate in vivo, and (iv) the new targeted Ca(2+) probes that allowed the "rediscovery" of these organelles in calcium signalling.
authors.affiliation: Department of Experimental and Diagnostic Medicine and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, 44100 Ferrara, Italy.
authors.forename: Katiuscia
authors.initials: K
authors.lastname: Bianchi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rimessi
authors.forename: Andrea
authors.initials: A
authors.lastname: Prandini
authors.forename: György
authors.initials: G
authors.lastname: Szabadkai
authors.forename: Rosario
authors.initials: R
authors.lastname: Rizzuto
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport; D008928:Mitochondria / Q000378:metabolism*
chemical_list: D000255:Adenosine Triphosphate; D002118:Calcium