title: [Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat].
abstract: OBJECTIVE
  To study the protective effect of Ligustrazine on IR after local cerebral ischemia of rat.
  
  
  METHODS
  Models of rat IR after local cerebral ischemia were prepared by electrocagulation of the middle cerebral artery, and changes of serum insulin, tomer necrosis factor-alpha (TNF-alpha), plasma endothelin-1 (ET-1), nitric oxide (NO) and nitric oxide synthase (NOS) were observed 2 weeks after the ischemia.
  
  
  RESULTS
  Ligustrazine could significantly reduce serum insulin (P < 0.01), the content of plasma ET-1 (P < 0.01) and serum TNF-alpha (P < 0.01), the activity of brain tissue NO and NOS (P < 0.01). The drug also increased insulin sensitivity indexes (ISI).
  
  
  CONCLUSIONS
  The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.
authors.affiliation: Department of Combination of Chinese and Western Medicine, Anhui College of Traditional Chinese Medicine, Hefei 230038, Anhui, China.
authors.forename: Yuan-jing
authors.initials: YJ
authors.lastname: Wang
authors.forename: An-hong
authors.initials: AH
authors.lastname: Jiang
authors.forename: Qin-mao
authors.initials: QM
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Bai
authors.forename: Ke-long
authors.initials: KL
authors.lastname: Ma
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000097:blood* / Q000209:etiology; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology; D011719:Pyrazines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D019332:Endothelin-1; D007328:Insulin; D018696:Neuroprotective Agents; D011719:Pyrazines; D014409:Tumor Necrosis Factor-alpha; D013482:Superoxide Dismutase; C017953:tetramethylpyrazine