The zinspy family of fluorescent zinc sensors: syntheses and spectroscopic investigations.
Four fluorescent sensors designed for Zn(II) detection that contain a fluorescein reporting group and a pyridyl-amine-thioether derivatized ligand moiety were prepared and their photophysical properties characterized. These "Zinspy" sensors are water soluble and generally display approximately 1.4- to approximately 4.5-fold fluorescence enhancement upon Zn(II) coordination, depending upon fluorescein halogenation and the number and nature of the zinc-binding appendages. The Zinspy sensors exhibit improved selectivity for zinc compared to the di-(2-picolyl)amine-based Zinpyr family.
Nolan
Elizabeth M
EM
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Lippard
Stephen J
SJ
D005452:Fluoresceins / Q000138:chemical synthesis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000032:analysis / Q000737:chemistry*
D005452:Fluoresceins; D005456:Fluorescent Dyes; D014867:Water; D015032:Zinc