title: [Infection with Chlamydophila pneumoniae as a cause of female infertility of tubal origin?].
abstract: OBJECTIVE
  A contribution to the role of Chlamydophila pneumoniae in women from the IVF program.
  
  
  METHODS
  A serological study proving the antibodies against the antigens of Chlamydophila pneumoniae (C. pneumoniae) and Chlamydia trachomatis (C. trachomatis) in women from the IVF program suffering from different factor of infertility.
  
  
  METHODS
  Veterinary Research Institute, Brno.
  
  
  METHODS
  The complement fixation test with chlamydial antigen and ELISA tests proving IgA and IgG antibodies against genus-specific antigen (cLPS) and species-specific chlamydial major outer membrane protein (cMOMP) of C. trachomatis and C. pneumoniae in the blood serum of 32 females being in the fertilization program due the tubal factor infertility have been estimated and the results compared with those obtained in 26 females being in the fertilization program due the ovarian factor and in 42 female with andrological factor, respectively.
  
  
  RESULTS
  The frequency of positive complement fixation test proved in the group of women with tubal factor infertility was significantly higher than in the groups with ovarial and andrological factor, respectively. The number of the strongly positive reactions (with high titres) in the group with tubal factor infertility was higher than in two remaining groups. The occurrence of species-specific IgG antibodies (anti-C. trachomatis) and chlamydia genus-specific IgA antibodies proved by means of ELISA in the group with tubal factor was statistically more frequent. The difference of the species-specific anti-C. pneumoniae antibodies in all three groups examined was not significant. The simultaneous occurrence of species-specific antibodies against anti-C. pneumoniae and C. trachomatis in the group with tubal factor was higher than in other groups (in comparing with the group with andrological factor statistically significant).
  
  
  CONCLUSIONS
  The opinion of the authors being in agreement with the view of most specialists is that the most important agent in the pathogenesis of tubal factor fertility is C. trachomatis. C. pneumoniae is above all a respiratory pathogen with a high prevalence and its impact for fertility disorders may be in the synergismus with C. trachomatis. The serological examination of both chlamydial infections should be a standard part of diagnostic algorithm.
authors.affiliation: Výzkumný ústav veterinárního lékarství, Brno.
authors.forename: L
authors.initials: L
authors.lastname: Pospísil
authors.forename: J
authors.initials: J
authors.lastname: Canderle
authors.forename: M
authors.initials: M
authors.lastname: Huser
authors.forename: H
authors.initials: H
authors.lastname: Stroblová
authors.forename: V
authors.initials: V
authors.lastname: Unzeitig
authors.forename: Z
authors.initials: Z
authors.lastname: Vezník
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D002690:Chlamydia Infections / Q000150:complications* / Q000175:diagnosis; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification; D003168:Complement Fixation Tests; D003251:Constriction, Pathologic; D004797:Enzyme-Linked Immunosorbent Assay; D005184:Fallopian Tube Diseases / Q000150:complications / Q000382:microbiology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial