title: Bioinformatics research on inter-racial difference in drug metabolism II. Analysis on relationship between enzyme activities of CYP2D6 and CYP2C19 and their relevant genotypes.
abstract: The enzyme activities of CYP2D6 and CYP2C19 show a genetic polymorphism, and the frequency of poor metabolizers (PMs) on these enzymes depends on races. We have analyzed frequencies of mutant alleles and PMs based on the published data in previous study (Shimizu, T. et al.: Bioinformatics research on inter-racial difference in drug metabolism, I. Analysis on frequencies of mutant alleles and poor metabolizers on CYP2D6 and CYP2C19.). The study shows that there were racial differences in the frequencies of each mutant allele and PMs. In the present study, the correlation between genotypes and drug-metabolizing enzyme activities was investigated. The result showed that enzyme activities varied according to the genotypes of subjects even in the same race. On the other hand, if subjects had the same genotypes, almost no racial differences were observed in drug-metabolizing enzyme activities. From these results, it was supposed that the racial differences in activities of these enzymes could be explained by the differences in distribution of genotypes. It would be possible to explain the racial differences in drug-metabolizing enzyme activities based on the differences on individual pharmacogenetic background information, not merely by comparison of frameworks such as races and nations.
authors.affiliation: Pharmacia.
authors.forename: Takako
authors.initials: T
authors.lastname: Shimizu
authors.forename: Hirohide
authors.initials: H
authors.lastname: Ochiai
authors.forename: Fredrik
authors.initials: F
authors.lastname: Asell
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Yokono
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Masashi
authors.initials: M
authors.lastname: Nitta
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Hama
authors.forename: Shizuyo
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Munehiro
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Taki
authors.forename: Kotoko
authors.initials: K
authors.lastname: Nakata
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Aida
authors.forename: Akira
authors.initials: A
authors.lastname: Ohashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Ozawa