Studies on the anti-inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Corr.
The serial extracts of the leaves of Aegle marmelos Corr. were investigated for anti-inflammatory property. The analgesic and antipyretic properties were also evaluated. The most of the extracts derived from the plant Aegle marmelos caused a significant inhibition of the carrageenan-induced paw oedema and cotton-pellet granuloma in rats. The extracts also produced marked analgesic activity by reduction the early and late phases of paw licking in mice. A significant reduction in hyperpyrexia in rats was also produced by the most of the extracts. This study was established anti-inflammatory, antinociceptive and antipyretic activities of the leaves of Aegle marmelos.
Arul
Veerappan
V
Department of Pharmacology and Environmental Toxicology, Dr. ALM Post-Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, Tamil Nadu, India. v_arul@hotmail.com
Miyazaki
Shigeru
S
Dhananjayan
Renganathan
R
D019342:Acetic Acid; D045471:Aegle; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005334:Fever / Q000188:drug therapy / Q000209:etiology; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D015003:Yeasts
D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan; D019342:Acetic Acid