Reasoning of spike glycoproteins being more vulnerable to mutations among 158 coronavirus proteins from different species.
In this study, we used the probabilistic models developed by us over the last several years to analyze 158 proteins from coronaviruses in order to determine which protein is more vulnerable to mutations. The results provide three lines of evidence suggesting that the spike glycoprotein is different from the other coronavirus proteins: (1) the spike glycoprotein is more sensitive to mutations, this is the current state of the spike glycoprotein, (2) the spike glycoprotein has undergone more mutations in the past, this is the history of spike glycoprotein, and (3) the spike glycoprotein has a bigger potential towards future mutations, this is the future of spike glycoprotein. Furthermore, this study gives a clue on the species susceptibility regarding different proteins.
Wu
Guang
G
Computational Mutation Project, DreamSciTech Consulting Co. Ltd., 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province, 518054, China. hongguanglishibahao@yahoo.com
Yan
Shaomin
S
D000704:Analysis of Variance; D000818:Animals; D002415:Cats; D017934:Coronavirus / Q000235:genetics*; D004285:Dogs; D006736:Horses; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics*; D008958:Models, Molecular; D009154:Mutation; D020539:Sequence Analysis, Protein; D064370:Spike Glycoprotein, Coronavirus; D014422:Turkeys; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics
D008562:Membrane Glycoproteins; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins; D014764:Viral Proteins