One-year change in cerebral glucose metabolism in patients with Alzheimer's disease.
By using [(18)F]-2-fluoro-deoxy-d-glucose and positron emission tomography, the authors studied changes in regional glucose metabolism after a 1-year interval in patients with mild Alzheimer's disease (AD). Glucose metabolism declined over time in the bilateral precuneus and posterior cingulate gyri and in the frontal, temporal, and parietal cortices. Glucose metabolism in these regions may be a useful measure of the progression of AD and a valid surrogate outcome measure of clinical drug trials.
Hirono
Nobutsugu
N
Department of Psychology, Kobegakuin University, 518 Arise, Ikawadani, Nishi-Ku, Kobe, 651-2180, Japan.
Hashimoto
Mamoru
M
Ishii
Kazunari
K
Kazui
Hiroaki
H
Mori
Etsuro
E
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D001923:Brain Chemistry / Q000502:physiology*; D001931:Brain Mapping; D018450:Disease Progression; D000077265:Donepezil; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007189:Indans / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D018697:Nootropic Agents / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals
D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D000077265:Donepezil; D005947:Glucose