title: [Sequence variability in Borna disease virus ORF II from human beings].
abstract: 40 clones from five psychiatric patients and three healthy blood donors in whom Borna disease virus (BDV) ORF II fragments in PBMC were previously proved by nested RT-PCR were sequenced and compared with BDV/MDCK. There were eleven point mutations in all clones compared with reported HE80-1, but no difference between human and BDV/MDCK clones. We found specific sequence variability at nt 1701 in ten clones from two psychiatric disorder patients (T-->C) and at nt 1696 in fifteen clones from three healthy blood donors (A-->T). This result strongly suggests there are some special gene divergence in BDV derived from human beings.
authors.affiliation: Institute of Neurology and Psychiatry, Chongqing University of Medical Sciences, China 400016.
authors.forename: P
authors.initials: P
authors.lastname: Xie
authors.forename: Y
authors.initials: Y
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D001483:Base Sequence; D001890:Borna Disease / Q000821:virology*; D001891:Borna disease virus / Q000235:genetics* / Q000302:isolation & purification; D014644:Genetic Variation; D006801:Humans; D001523:Mental Disorders / Q000821:virology; D008969:Molecular Sequence Data; D009154:Mutation; D016366:Open Reading Frames; D016415:Sequence Alignment