Sensitization to propolis in 1255 children undergoing patch testing.
To investigate the frequency and the features of contact sensitization to propolis in children, we patch tested 1255 consecutive children suspected of allergic contact dermatitis with propolis 20% petrolatum over an 8-year period (1995-2002). Positive responses were observed in 5.9% of patch-tested subjects, with a significantly higher frequency in boys than in girls. The dermatitis was localized mainly on the face, hands and limbs. A significant linear increase in the annual frequency of propolis allergy was noted. Confirming literature data, a significant association with balsam of Peru sensitivity was present in children reacting to propolis, linked to the presence of common constituents in the 2 substances. In conclusion, based on our data, we suggest that propolis should not be used in topical products for children because of its high sensitization rate at the paediatric age.
Giusti
Francesca
F
Department of Dermatology, University of Modena and Reggio Emilia, 41100 Modena, Italy.
Miglietta
Roberta
R
Pepe
Patrizia
P
Seidenari
Stefania
S
D000485:Allergens / Q000009:adverse effects*; D001453:Balsams / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology*; D003876:Dermatitis, Atopic / Q000453:epidemiology; D005148:Facial Dermatoses / Q000453:epidemiology; D005260:Female; D006229:Hand Dermatoses / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007558:Italy / Q000453:epidemiology; D007868:Leg Dermatoses / Q000453:epidemiology; D008297:Male; D010328:Patch Tests / Q000706:statistics & numerical data*; D011429:Propolis / Q000009:adverse effects*; D012737:Sex Factors; D034941:Upper Extremity / Q000473:pathology
D000485:Allergens; D001453:Balsams; C025080:Peruvian balsam; D011429:Propolis