Theoretical approaches and practical investigations in carbopol buccal patches for drug delivery.
This paper describes the theoretical approaches in the peeling test method which can be used to evaluate the bioadhesive patches for buccal drug delivery purposes. The effects of patch thickness and the peeling rate on the bioadhesion of buccal patches were investigated from a theoretical point of view. The influence of a crosslinking agent on the swelling and bioadhesive properties of the patches was also evaluated.
Guo
J H
JH
Aqualon Division, Hercules Incorporated, 500 Hercules Rd., Wilmington Delaware 19808-1599, USA.
Cooklock
K M
KM
D000180:Acrylic Resins; D000278:Administration, Buccal; D003432:Cross-Linking Reagents; D016503:Drug Delivery Systems / Q000379:methods*; D011145:Polyvinyls / Q000008:administration & dosage*; D011480:Protease Inhibitors / Q000008:administration & dosage*
D000180:Acrylic Resins; D003432:Cross-Linking Reagents; D011145:Polyvinyls; D011480:Protease Inhibitors; C006912:carboxypolymethylene