Viruses and Toll-like receptors.
Production of inflammatory cytokines and type I interferons by mammalian cells is mediated through virus-specific activation of Toll-like receptors (TLRs). Known roles for different TLRs and speculation as to their roles in viral pathogenesis and immunity are discussed in this review.
Finberg
Robert W
RW
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB 228, Worcester, MA 01605, USA. robert.finberg@umassmed.edu
Kurt-Jones
Evelyn A
EA
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D051193:Toll-Like Receptors; D014780:Viruses / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*
D016207:Cytokines; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors