No changes in serum ghrelin levels in female patients with bulimia nervosa.
It has been reported that fasting plasma ghrelin levels may play a role in the pathophysiology of eating disorders. In this study, the authors examined whether serum levels of ghrelin were altered in the patients with bulimia nervosa (BN). We enrolled 18 female patients with BN, and 21 age-matched female controls for this study. Eating-related psychopathology, depressive symptoms were evaluated by using the Bulimic Investigatory Test, Edinburgh (BITE) and the 17-item Hamilton Depression Rating Scale (HDRS). Serum levels of ghrelin were measured by Ghrelin enzyme immunoassay kit. There were no significant differences in serum ghrelin levels between the patients with BN and normal controls. Furthermore, the authors did not found correlation between serum ghrelin levels and clinical parameters in the patients with BN. Our study suggests that serum ghrelin levels in the patients with BN were indistinguishable from normal controls. Therefore, it is unlikely that ghrelin plays a role in the pathophysiology of BN.
Nakazato
Michiko
M
Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chiba City, Chiba 260-8670, Japan. nakazato@faculty.chiba-u.jp
Hashimoto
Kenji
K
Shiina
Akihiro
A
Koizumi
Hiroki
H
Mitsumoti
Makoto
M
Imai
Masao
M
Shimizu
Eiji
E
Iyo
Masaomi
M
D000293:Adolescent; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood; D002032:Bulimia / Q000097:blood* / Q000523:psychology; D005260:Female; D054439:Ghrelin; D006801:Humans; D036361:Peptide Hormones / Q000097:blood*; D011569:Psychiatric Status Rating Scales
D019208:Brain-Derived Neurotrophic Factor; D054439:Ghrelin; D036361:Peptide Hormones