title: [Experimental study on estrogenic function of triphasic contraceptive tablets].
abstract: OBJECTIVE
  To assess the estrogenic effect and activity of oral triphasic contraceptive tablets and provide the theoretical foundation for the use of homemade Kalirui in the treatment of metrorrhagic, menometrorrhagic, oligomenorrheic, and polymenorrheic dysfunctional uterine bleeding.
  
  
  METHODS
  The vaginal smears of mice treated by triphasic contraceptive tablets (Kalirui and Trinordiol) were examined using light microscope. Radiational receptor analysis was made to measure the estrogenic effect of Kalirui and Trinordiol on Compared with the control group, the three dosage groups of homemade (Kalirui) rabbit uterus.
  
  
  RESULTS
  triphasic contraceptive tablets and the import tablets (Trinordiol) group all showed obviously accelerate vagina kera-epithelium forming (P < 0.01), especially in the first phase and second phase. Both Kalirui and Trinordiol were found to have higher affinity to estrogenic receptor, and there were no significant differences between them Kalirui and Trinordiol triphasic oral contraceptive and the estrogenic standard sample (P > 0.05).
  
  
  CONCLUSIONS
  tablets have apparently estrogenic effect and activity.
authors.affiliation: Department of Pharmacology, West China of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
authors.forename: Fangju
authors.initials: F
authors.lastname: Yang
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.forename: Guanqiang
authors.initials: G
authors.lastname: Zhou
authors.forename: Suznen
authors.initials: S
authors.lastname: Zhou
authors.forename: Ailan
authors.initials: A
authors.lastname: Fan
mesh_terms: D000818:Animals; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination / Q000494:pharmacology*; D005260:Female; D016912:Levonorgestrel / Q000494:pharmacology; D051379:Mice; D011897:Random Allocation; D011960:Receptors, Estrogen / Q000032:analysis / Q000187:drug effects; D014621:Vagina / Q000166:cytology*
chemical_list: D003280:Contraceptives, Oral, Synthetic; D004968:Estrogens, Non-Steroidal; D011960:Receptors, Estrogen; D016912:Levonorgestrel; D019304:Ethinyl Estradiol-Norgestrel Combination