title: Pyrimidine containing RSV fusion inhibitors.
abstract: The knowledge of SAR in a series of biphenyl anionic RSV inhibitors has been broadened by synthesis and testing of analogs with pyrimidine linkers. Generally, pyrimidine compounds were much harder to synthesize, and their anti-RSV activity was lower in comparison with triazine analogs.
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA. nikitea@wyeth.com
authors.forename: Antonia
authors.initials: A
authors.lastname: Nikitenko
authors.forename: Yuri
authors.initials: Y
authors.lastname: Raifeld
authors.forename: Boris
authors.initials: B
authors.lastname: Mitsner
authors.forename: Howard
authors.initials: H
authors.lastname: Newman
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014227:Triazines / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D011743:Pyrimidines; D014227:Triazines