title: [The synthesis and antiherpetic activity of acyclovir phosphonate esters].
abstract: Alkyl esters of acyclovir phosphite, alkoxycarbonylphosphonate, ethoxycarbonylmethylphosphonate, and aminocarbonylphosphonate were synthesized. Most of them were shown to inhibit the replication of type 1 herpes simplex virus in Vero cell culture. The stability in phosphate buffer and human blood serum was studied for several of the derivatives. A correlation between the stability and antiviral activity of the synthesized compounds is discussed. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 6; see also http://www.maik.ru.
authors.forename: M V
authors.initials: MV
authors.lastname: Ias'ko
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Ulanova
authors.forename: V L
authors.initials: VL
authors.lastname: Andronova
authors.forename: A V
authors.initials: AV
authors.lastname: Ivanov
authors.forename: I L
authors.initials: IL
authors.lastname: Karpenko
authors.forename: M K
authors.initials: MK
authors.lastname: Kukhanova
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Skoblov
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002522:Chlorocebus aethiops; D004355:Drug Stability; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000494:pharmacology; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
chemical_list: D063065:Organophosphonates; D000212:Acyclovir