title: Antiepileptogenic and anticonvulsant activity of interleukin-1 beta in amygdala-kindled rats.
abstract: Ischaemic, excitotoxic and traumatic brain injuries have been associated with the occurrence of epileptic seizures. Microglia, the principal immune cells in the brain, produce a variety of proinflammatory and cytotoxic factors especially interleukin-1 (IL-1) early after an acute insult. We studied the effect of intracerebroventricularly administered IL-1beta on seizure acquisition and on fully kindled seizures in amygdala kindling model of epilepsy. IL-1beta (0.01 ng/rat) retarded acquisition of kindled behavioral seizures and growth of afterdischarges (AD). IL-1beta (0.01-10 ng/rat) also exhibited significant anticonvulsant effect on established kindled seizures and AD duration. This effect began 0.5 h after administration and was continued up to 72 h. Pretreatment of the kindled animals with nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester, or cyclooxygenase inhibitor, piroxicam, reversed the anticonvulsant effect of IL-1beta at early time points. Although most of the previous studies indicate a proconvulsant or convulsant property of IL-1, our results support a protective and antiepileptogenic role of IL-1beta.
authors.affiliation: Department of Physiology and Pharmacology, Institute Pasteur of Iran, Tehran, Iran. sayyah@pasteur.ac.ir
authors.forename: M
authors.initials: M
authors.lastname: Sayyah
authors.forename: S
authors.initials: S
authors.lastname: Beheshti
authors.forename: M A
authors.initials: MA
authors.lastname: Shokrgozar
authors.forename: A
authors.initials: A
authors.lastname: Eslami-far
authors.forename: Z
authors.initials: Z
authors.lastname: Deljoo
authors.forename: A R
authors.initials: AR
authors.lastname: Khabiri
authors.forename: A
authors.initials: A
authors.lastname: Haeri Rohani
mesh_terms: D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology; D007375:Interleukin-1 / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000927:Anticonvulsants; D007375:Interleukin-1