Exercise physiology versus inactivity physiology: an essential concept for understanding lipoprotein lipase regulation.
Some health-related proteins such as lipoprotein lipase may be regulated by qualitatively different processes over the physical activity continuum, sometimes with very high sensitivity to inactivity. The most powerful process known to regulate lipoprotein lipase protein and activity in muscle capillaries may be initiated by inhibitory signals during physical inactivity, independent of changes in lipoprotein lipase messenger RNA.
Hamilton
Marc T
MT
Department of Biomedical Sciences, University of Missouri-Columbia, Columbia, MO, USA. hamiltonm@missouri.edu
Hamilton
Deborah G
DG
Zderic
Theodore W
TW
D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood; D015444:Exercise / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism*; D009043:Motor Activity / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D009124:Muscle Proteins / Q000096:biosynthesis; D018482:Muscle, Skeletal / Q000201:enzymology* / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism
D008076:Cholesterol, HDL; D009124:Muscle Proteins; D012333:RNA, Messenger; D008071:Lipoprotein Lipase