Comparative texturometric analysis of hydrogels based on cellulose derivatives, carraghenates, and alginates: evaluation of adhesiveness.
This paper reports a texturometric study of hydrogels based on cellulose derivatives, carraghenates (with or without Na+ or K+), and alginates (associated or not with Ca++). The stiffness, elasticity, and cohesiveness are evaluated and the influence of the nature and the concentration of gelling agent on the adhesiveness, an indicator of bioadhesion, is discussed. The highest adhesiveness values are found among the semi-stiff gels, particularly with those based on either sodium or potassium alginate, or cellulose derivatives. The least satisfactory results are obtained with the formulations associating carraghenates and Na+ or K+.
Vennat
B
B
Service de Pharmacie Galénique et Pharmacotechnie UFR Pharmacie 28, place H. Dunant, BP 38, 63001 Clermont-Ferrand, France.
Lardy
F
F
Arvouet-Grand
A
A
Pourrat
A
A
D000268:Adhesiveness; D000464:Alginates / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry; D002351:Carrageenan / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D020723:Glucuronic Acid / Q000737:chemistry*; D006603:Hexuronic Acids / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D013997:Time Factors
D000464:Alginates; D006603:Hexuronic Acids; D020100:Hydrogels; D020723:Glucuronic Acid; D002351:Carrageenan; D002482:Cellulose; D002118:Calcium