title: Changes in dolichol and pentosidine levels in the age-mismatched heterotopically transplanted rat heart.
abstract: To address some basic questions about primary and secondary events in the process of aging in different cell and tissue types, we studied changes in the levels of biomarkers of the aging cells (dolichol) and connective tissue (pentosidine) in the heart of older (22-month-old) Lewis rats heterotopically transplanted in younger (3-month-old) syngenic recipients. Results showed that age-mismatched transplantation did not alter the age-related accumulation of dolichol and significantly reduced the accumulation of pentosidine in cardiac tissue. It is concluded that aging of heart muscle and connective tissues is controlled by two independent clocks; that accumulation of dolichol in older tissues may be a primary consequence of the process of aging, whereas the accumulation of pentosidine may be secondary, perhaps to changes in circulating cells endowed with advanced glycation end products-specific receptors; in the perspective of organ transplantation, the environment of a younger host may positively interact with the graft and rejuvenate its collagen.
authors.affiliation: Department of Experimental Pathology, The University of Genova, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Cavallini
authors.forename: Rossella
authors.initials: R
authors.lastname: Di Stefano
authors.forename: Gianluca
authors.initials: G
authors.lastname: Bonanomi
authors.forename: Franco
authors.initials: F
authors.lastname: Mosca
authors.forename: Patrizio
authors.initials: P
authors.lastname: Odetti
authors.forename: Ilaria
authors.initials: I
authors.lastname: Parentini
authors.forename: Alessia
authors.initials: A
authors.lastname: Poggi
authors.forename: Simona
authors.initials: S
authors.lastname: Rossi
authors.forename: Ettore
authors.initials: E
authors.lastname: Bergamini
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism*; D001683:Biological Clocks; D003238:Connective Tissue / Q000378:metabolism; D004286:Dolichols / Q000378:metabolism*; D016027:Heart Transplantation; D008239:Lysine / Q000031:analogs & derivatives* / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010210:Papillary Muscles / Q000378:metabolism; D051381:Rats; D011917:Rats, Inbred Lew; D016042:Transplantation, Heterotopic
chemical_list: D004286:Dolichols; D001120:Arginine; C062187:pentosidine; D008239:Lysine