A third case of cardiac neoplasm in a fetus with Beckwith-Wiedemann syndrome: epicardial angiofibroma.
OBJECTIVE
A personal observation of a 20-week-old fetus with Beckwith-Wiedemann syndrome (BWS) presenting epicardial angiofibroma prompted us to evaluate cardiac neoplasms in this genetic condition.


METHODS
We performed an autopsy and a histological evaluation of the fetus, and searched the literature for cardiac anomalies in BWS.


RESULTS
Although cardiac tumors are exceptional and although BWS is rare, we found two other cardiac neoplasms in infants with BWS, whereas no more than one was expected.


CONCLUSIONS
Besides an excess of cardiac malformation, BWS seems to favor an excess of cardiac tumors, which may occur very early.
Satgé
Daniel
D
Laboratoire d'Anatomie Pathologique Centre Hospitalier, Tulle, France. daniel.satge@ch-tulle.fr
Vidalo
Evelyne
E
Desfarges
François
F
de Geeter
Bernard
B
D000328:Adult; D018322:Angiofibroma / Q000209:etiology* / Q000473:pathology; D001506:Beckwith-Wiedemann Syndrome / Q000150:complications*; D005260:Female; D005315:Fetal Diseases; D006222:Hamartoma / Q000209:etiology / Q000473:pathology; D006331:Heart Diseases / Q000209:etiology / Q000473:pathology; D006338:Heart Neoplasms / Q000209:etiology* / Q000473:pathology; D006801:Humans; D010496:Pericardium; D011247:Pregnancy; D011261:Pregnancy Trimester, First