[An investigation on the percentages of TRAb-producing cells in Graves disease].
OBJECTIVE
To investigate the presence of the TRAb-producing cell precursors in the cases of Graves disease.


METHODS
Peripheral lymphocytes were infected with Epstein-Barr virus, a kind of lymphocyte precursor stimulator, and were stimulated to produce TRAb.


RESULTS
The percentages of TRAb-producing cells from Graves disease group were obviously higher than those from healthy control group. The isotype of TRAb in The frequencies of supernants of these EBV-transformed B lymphocytes was predominatly IgM.


CONCLUSIONS
TRAb-specific precursors were higher in the cases of Graves disease than in healthy control.
Jia
Weiguo
W
Division of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China.
An
Zhenmel
Z
Chen
Decai
D
Wei
Songquan
S
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000378:metabolism / Q000821:virology; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000276:immunology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors; D011989:Receptors, Thyrotropin / Q000276:immunology*
D001323:Autoantibodies; D007075:Immunoglobulin M; D011498:Protein Precursors; D011989:Receptors, Thyrotropin