Extremely potent antifeedant neo-clerodane derivatives of scutecyprol A.
Two known neo-clerodane diterpenoids, scutecyprol A (1) and scutalbin C (2), have been isolated from the acetone extract of the aerial parts of Scutellaria sieberi. The antifeedant activity of scutecyprol A (1), of its 15-oxo derivative (3), and of several halohydrins (4-9), synthesized starting from compounds 1 and 3, against Spodoptera littoralis have been determined and structure-antifeedant relationships are discussed.
Rosselli
Sergio
S
Dipartimento di Chimica Organica E. Paterno, Università di Palermo, viale delle Scienze, Parco d'Orleans II, 90128 Palermo, Italy.
Maggio
Antonella
A
Piozzi
Franco
F
Simmonds
Monique S J
MS
Bruno
Maurizio
M
D000818:Animals; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification*; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*; D031363:Scutellaria / Q000737:chemistry*; D018411:Spodoptera
D045785:Diterpenes, Clerodane; D007306:Insecticides; C495516:scutalbin C; C495515:scutecyprol A