[Associations between aldosterone synthase gene polymorphisms and left ventricular structure and function in Chinese normal Han People].
OBJECTIVE
The aim of the present study was to investigate the association between a polymorphism of the aldosterone synthase gene CYP11B2 and left ventricular structure and function in Chinese Han people.


METHODS
One handred and ten persons aged 20 to 49 years were studies by echocardiography to assess left ventricular size, mass and function. The subjects were genotyped with the use of PCR-RFLP.


RESULTS
Three genotypes for aldosterone synthase at position -334 in the transcriptional regulatory region were found: TT, TC and CC. The distribution of sex and arterial blood pressure was homogeneous in the aldosterone synthase genotype groups. No significant associations of echocardiographic LV dimensions, mass and function with a specific aldosterone synthase genotype were noted.


CONCLUSIONS
The above data are not in favor of a significant association between the polymorphisms of aldosterone synthase gene CYP11B2 and the LV structure and function in Chinese normal Han people.
Rao
Li
L
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhang
Qing
Q
Liang
Weibo
W
Huang
Minghui
M
Zhang
Lin
L
D000328:Adult; D002681:China / Q000208:ethnology; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D004452:Echocardiography; D005260:Female; D005838:Genotype; D006352:Heart Ventricles / Q000033:anatomy & histology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*
D019405:Cytochrome P-450 CYP11B2