title: Distortion of normal pituitary structures in sellar pathologies on MRI.
abstract: OBJECTIVE
  This study was undertaken to assess the displacement patterns and shifts of the normal pituitary gland in sellar pathologies on MRI and to determine if the position of the bright spot (BS) represents a predicting factor for the position of the residual adenohypophysis (RAH) in pathological conditions.
  
  
  METHODS
  In a control group of 102 patients without any pituitary pathology, the presence of the BS was evaluated. In 100 patients with intra- or suprasellar pathologies, presence and respective topography of BS and RAH were scrutinized on MRI, according to lesion type, size, endocrine status and intra-operative findings in the surgical group.
  
  
  RESULTS
  The BS was visible in 91.2% of 102 cases in the control group, as compared to 75 of the 100 patients with sellar lesions. Location of RAH was identified in 58% of the patients, and RAH enhanced more than the lesion in all cases after contrast infusion. The RAH was identified in 65.3% of the 75 "BS positive" patients, as compared to 36% of the 25 "BS negative". The normal residual gland was visualized intra-operatively in 63.5% of the 52 operated patients: in 37 "BS positive" patients, it was visualized intra-operatively in 81.1% and in 28 "RAH positive" patients, it was identified in 82.1%.
  
  
  CONCLUSIONS
  The BS can be identified in the majority and RAH in more than half of the cases with pituitary lesions on MRI. Positions of both the BS and RAH help predict the location of the normal residual gland during surgery and, therefore, may contribute to preserving the pituitary function.
authors.affiliation: Division of Neurosurgery, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Burak
authors.initials: B
authors.lastname: Sade
authors.forename: Gérard
authors.initials: G
authors.lastname: Mohr
authors.forename: Jean Lorrain
authors.initials: JL
authors.lastname: Vézina
mesh_terms: D000718:Anatomy, Regional; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010900:Pituitary Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D010902:Pituitary Gland / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D011237:Predictive Value of Tests; D011859:Radiography; D012016:Reference Values; D012189:Retrospective Studies; D012658:Sella Turcica / Q000473:pathology*