Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii.
The interaction between sulbactam and imipenem was evaluated with four clinical isolates of Acinetobacter baumannii, including two isolates resistant to imipenem, one of which produced IMP-1 metallo-beta-lactamase. Two isolates (one of which was imipenem-resistant) were sulbactam-resistant by undefined mechanisms. MICs were determined by standard broth microdilution methods. Time-kill assays with imipenem and sulbactam, alone or in combination at 0.5 x MIC and 1 x MIC, showed a synergic effect in all four isolates of A. baumannii after incubation for 0, 4, 8 and > 24 h at 35 degrees C.
Choi
J Y
JY
Department of Internal Medicine and AIDS Research Institute, BK21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Park
Y Soo
YS
Cho
C H
CH
Park
Y Seon
YS
Shin
S Y
SY
Song
Y G
YG
Yong
D
D
Lee
K
K
Kim
J M
JM
D040981:Acinetobacter baumannii / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013407:Sulbactam / Q000494:pharmacology*; D013997:Time Factors; D065093:beta-Lactamase Inhibitors
D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors; D015378:Imipenem; D013407:Sulbactam