title: Sirolimus-eluting stents for percutaneous coronary intervention in acute myocardial infarction Lesson from a case-controlled comparison of bare metal versus drug-eluting stents in thrombus-laden lesions.
abstract: BACKGROUND
  Given the encouraging results on early restenosis rate with drug-eluting coronary stents, both safety and 6 months outcomes of PCI with sirolimus-eluting stents (SES) in acute myocardial infarction are scarce.
  
  
  RESULTS
  Fifty consecutive patients with acute myocardial infarction were subjected to acute PCI with SES and compared to 50 matched control patients who received a bare metal stent (BMS). All patients were followed over 6 months; in addition repeat angiography was obtained in 88.0% of SES and 92.0% of BMS patients. As a result of matching both groups were similar with regard to demographic, clinical, and infarction characteristics, as well as procedural data and adjunctive medication. SES diameter was 3.0 +/- 0.1 versus 3.3 +/- 0.5 mm with BMS, while the length of stented segment was 24 +/- 11 mm with SES versus 16 +/- 8 mm with BMS (p<0.05). No subacute stent thrombosis occurred in either group. At 6 months, all-cause mortality was 2.0% with SES, and 4.0% with BMS (n. s.); reinfarction rate was 2.0% in both groups, but binary restenosis rate (4.0 versus 18.0%; p<0.05) and target vessel revascularization (TVR) were improved with SES (2.0 versus 16.0%; p<0.05) resulting in lower MACE rate of 6.0 versus 22.0% with BMS (p<0.05).
  
  
  CONCLUSIONS
  Placement of SES with PCI for myocardial infarction is feasible and as safe as BMS; 6-month outcome is superior with SES due to the lower rate of both angiographic restenosis and TVR.
authors.affiliation: University Hospital Rostock, Department of Internal Medicine, Division of Cardiology, Ernst-Heydemann-Strasse 6, 18057 Rostock, Germany. frank.weber@medizin.uni-rostock.de
authors.forename: F
authors.initials: F
authors.lastname: Weber
authors.forename: H
authors.initials: H
authors.lastname: Schneider
authors.forename: C
authors.initials: C
authors.lastname: Schwarz
authors.forename: C
authors.initials: C
authors.lastname: Holzhausen
authors.forename: M
authors.initials: M
authors.lastname: Petzsch
authors.forename: C A
authors.initials: CA
authors.lastname: Nienaber
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D016022:Case-Control Studies; D020099:Coated Materials, Biocompatible; D015331:Cohort Studies; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000517:prevention & control; D018795:Device Approval; D004869:Equipment Safety; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D011474:Prosthesis Design; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D020123:Sirolimus