title: Philadelphia chromosome-positive acute lymphoblastic leukemia secondary to chemoradiotherapy for Ewing sarcoma. Report of two cases and concise review of the literature.
abstract: Survivors of childhood solid tumors including Ewing sarcoma (ES) have an increased risk of secondary malignant neoplasms (SMNs) as a consequence of exposure to chemotherapy and/or radiation (see: Bhatia S, Sklar C. Nat Rev Cancer 2002;2:124-132). The most common hematologic SMNs are myelodysplasia (MDS) and acute myelogenous leukemia (AML). Acute lymphoblastic leukemia (ALL) is uncommon in this patient population, and Philadelphia chromosome positive (Ph+) ALL in particular, is rare. We report herein two cases of young adult patients who were both diagnosed with Ph+ ALL 19 years after successful treatment for ES with combined modality therapy. A review of the relevant literature follows the case reports.
authors.affiliation: Division of Hematology, City of Hope National Medical Center, Duarte, CA 91010, USA. dsnyder@coh.org
authors.forename: David S
authors.initials: DS
authors.lastname: Snyder
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Stein
authors.forename: Margaret R
authors.initials: MR
authors.lastname: O'Donnell
authors.forename: Karl
authors.initials: K
authors.lastname: Gaal
authors.forename: Marilyn L
authors.initials: ML
authors.lastname: Slovak
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Forman
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy / Q000009:adverse effects; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology*; D011832:Radiation Injuries / Q000150:complications*; D012512:Sarcoma, Ewing / Q000188:drug therapy* / Q000532:radiotherapy*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents