Application of tandem Ugi multi-component reaction/ring closing metathesis to the synthesis of a conformationally restricted cyclic pentapeptide.
A conformationally restricted cyclic pentapeptide, containing an unsaturated 9-membered lactam as a semi-rigid scaffold, was prepared in a very convergent manner, through tandem Ugi reaction/ring closing metathesis.
Dietrich
Silvia Anthoine
SA
Department of Chemistry and Industrial Chemistry, via Dodecaneso 31, 16146, Genova, Italy.
Banfi
Luca
L
Basso
Andrea
A
Damonte
Gianluca
G
Guanti
Giuseppe
G
Riva
Renata
R
D018360:Crystallography, X-Ray; D003500:Cyclization; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D011487:Protein Conformation; D013237:Stereoisomerism
D010456:Peptides, Cyclic