Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent.
Bakuchiol, extracted from the plant Psoralea corylifolia, has been proven to have anti-tumor, cytotoxic, anti-microbial and anti-inflammatory activity. In order to study if radiolabeled bakuchiol exhibits enhanced cytotoxicity, bakuchiol was radiolabeled with 125I. In-vitro uptake studies of 125I-bakuchiol were carried out using LS-A (lymphosarcoma) and barcl-95 (radiation-induced thymic lymphoma) ascitic and solid tumor cells of murine origin. In both LS-A and barcl-95, 125I-bakuchiol showed significant uptake. Viability studies showed that the radioiodinated compound showed greater cytotoxic effect than bakuchiol.
Bapat
Ketaki
K
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Chintalwar
G J
GJ
Pandey
Usha
U
Thakur
V S
VS
Sarma
H D
HD
Samuel
Grace
G
Pillai
M R A
MR
Chattopadhyay
S
S
Venkatesh
Meera
M
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics / Q000494:pharmacology*; D007553:Isotope Labeling; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000532:radiotherapy; D051379:Mice; D010636:Phenols / Q000493:pharmacokinetics / Q000494:pharmacology*; D010936:Plant Extracts / Q000378:metabolism; D029907:Psoralea / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D007457:Iodine Radioisotopes; D010636:Phenols; D010936:Plant Extracts; D019275:Radiopharmaceuticals; C012765:bakuchiol