title: E-cadherin gene C-160A promoter polymorphism and risk of non-cardia gastric cancer in a Chinese population.
abstract: OBJECTIVE
  To test the hypothesis that E-cadherin gene (CDH1) C-160A promoter variant genotype is associated with an increased risk for developing gastric cancer.
  
  
  METHODS
  In this population-based case-control study of gastric cancer in Jiangsu Province, China, we performed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to genotype the C-160A polymorphism of CDH1 promoter in 206 non-cardia gastric cancer patients and 261 age- and sex-matched but unrelated cancer-free controls.
  
  
  RESULTS
  The frequencies of genotypes CC, CA and AA were 57.8%, 36.4% and 5.8% in gastric cancer cases, respectively, and 58.2%, 34.9% and 6.9% in controls respectively. The distributions of CDH1 genotypes were not significantly different between gastric cancer cases and controls (P = 0.87 for genotype frequency and P = 0.92 for allele frequency). Compared with the CC genotype, the CA and AA genotypes were not associated with an increased risk for non-cardia gastric cancer (adjusted odds ratios (OR) = 1.15, and 95% confidence interval (95% CI) = 0.78-1.72 for CA genotype, and OR = 0.90 and 95% CI = 0.42-2.01 for AA genotype).
  
  
  CONCLUSIONS
  E-cadherin gene C-160A promoter polymorphism may not play a major role in the etiology of non-cardia gastric cancer in Chinese population.
authors.affiliation: Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, Nanjing 210029, Jiangsu Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Yao-Chu
authors.initials: YC
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Shen
authors.forename: Rong-Bin
authors.initials: RB
authors.lastname: Yu
authors.forename: Ju-Yin
authors.initials: JY
authors.lastname: Niu
authors.forename: Jian-Tao
authors.initials: JT
authors.lastname: Guo
authors.forename: Xu
authors.initials: X
authors.lastname: Hu
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D015820:Cadherins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology* / Q000235:genetics*
chemical_list: D015820:Cadherins