title: Current status of cardiac MRI in small animals.
abstract: Cardiac magnetic resonance imaging (MRI) on small animals is possible but remains challenging and not well standardized. This publication aims to provide an overview of the current techniques, applications and challenges of cardiac MRI in small animals for researchers interested in moving into this field. Solutions have been developed to obtain a reliable cardiac trigger in both the rat and the mouse. Techniques to measure ventricular function and mass have been well validated and are used by several research groups. More advanced techniques like perfusion imaging, delayed enhancement or tag imaging are emerging. Regarding cardiac applications, not only coronary ischemic disease but several other pathologies or conditions including cardiopathies in transgenic animals have already benefited from these new developments. Therefore, cardiac MRI has a bright future for research in small animals.
authors.affiliation: Digital Imaging Unit, Radiology and Medical Informatics Department, Geneva University Hospitals, CH-1211, Geneva 14, Switzerland. jean-paul.vallee@sim.hcuge.ch
authors.forename: J-P
authors.initials: JP
authors.lastname: Vallée
authors.forename: M K
authors.initials: MK
authors.lastname: Ivancevic
authors.forename: D
authors.initials: D
authors.lastname: Nguyen
authors.forename: D R
authors.initials: DR
authors.lastname: Morel
authors.forename: M
authors.initials: M
authors.lastname: Jaconi
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000175:diagnosis / Q000662:veterinary; D004195:Disease Models, Animal; D004562:Electrocardiography / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends / Q000662:veterinary*; D051379:Mice; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000662:veterinary; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis* / Q000662:veterinary; D051381:Rats; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000662:veterinary