title: [Clinical observation on effect of xuefu zhuyu decoction in treating patients with liver fibrosis caused by chronic hepatitis B].
abstract: OBJECTIVE
  To observe the effect of Xuefu Zhuyu decoction (XZD) on the chronic hepatitis B caused liver fibrosis (CHBLF) and the portal hemodynamics.
  
  
  METHODS
  Sixty patients with CHBLF were randomly divided into two groups, the 28 patients in the treated group were treated with oral intake of XZD and conventional liver protective treatment, the 32 patients in the control group were treated with conventional liver protective treatment alone, the therapeutic course for both groups was 3 months. Serum liver fibrosis criteria and portal dynamical criteria were observed before and after treatment.
  
  
  RESULTS
  Comparison of the remarkable effective rate between the two groups showed significant difference. After treatment, in the treated group, all the serum criteria for liver fibrosis (HA, PCIII, LN) and criteria for portal trunk hemodynamics, such as mean velocity and quantity of blood flow were significantly improved (P < 0.05 or P < 0.01), as compared with those in the control group, the difference was also significant (P < 0.05 or P < 0.01).
  
  
  CONCLUSIONS
  XZD has definite therapeutic effect on chronic hepatitis B caused liver fibrosis.
authors.affiliation: Xinhua Hospital Affiliated to Zhejiang TCM College, Hangzhou. cshru@163.com
authors.forename: Qing-jing
authors.initials: QJ
authors.lastname: Ru
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Tang
authors.forename: Zhen-e
authors.initials: ZE
authors.lastname: Zhang
authors.forename: Qigui
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D024061:Collagen Type III / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011169:Portal Vein / Q000503:physiopathology
chemical_list: D024061:Collagen Type III; D004365:Drugs, Chinese Herbal; D006820:Hyaluronic Acid