title: Pregnancy outcome after IVF and ICSI in unexplained, endometriosis-associated and tubal factor infertility.
abstract: BACKGROUND
  This study was undertaken in order to compare pregnancy outcome after IVF and ICSI in unexplained and endometriosis-associated infertility using tubal factor infertility as controls.
  
  
  METHODS
  This was a retrospective cohort study of early IVF/ICSI pregnancies verified by serum hCG measurement, comparing the subsequent outcome in unexplained (n = 274) and minimal endometriosis-associated (n = 212) with tubal factor (n = 540) infertility as controls. From January 1990 to December 2002, 1026 conception cycles after treatment with IVF or ICSI complied with the inclusion criteria.
  
  
  RESULTS
  Live birth rate, twin birth rate after transfer of two embryos and abortion rate prior to 6 weeks of gestation were superior for the unexplained (78.8, 23.5 and 11.7%) compared to endometriosis-associated (66.0, 15.0 and 19.3%) and tubal factor (66.7, 18.1 and 18.0%) infertility groups (P < 0.05). Compared to the endometriosis-associated, the unexplained infertility group attained a higher pregnancy rate after the first treatment cycle (P < 0.05).
  
  
  CONCLUSIONS
  The overall better outcome for the unexplained infertility group with respect to live birth rate, twin birth rate and early abortion rate compared to the minimal peritoneal endometriosis-associated and tubal factor infertility groups might be a guide to select diagnostic groups for single embryo transfer and be useful in patient counselling.
authors.affiliation: Department of Obstetrics and Gynaecology, National Hospital, University of Oslo, Sognsvannsveien 20, 0027 Oslo, Norway. anne.omland@rikshospitalet.no
authors.forename: Anne K
authors.initials: AK
authors.lastname: Omland
authors.forename: Thomas
authors.initials: T
authors.lastname: Abyholm
authors.forename: Peter
authors.initials: P
authors.lastname: Fedorcsák
authors.forename: Gudvor
authors.initials: G
authors.lastname: Ertzeid
authors.forename: Nan B
authors.initials: NB
authors.lastname: Oldereid
authors.forename: Sverre
authors.initials: S
authors.lastname: Bjercke
authors.forename: Tom
authors.initials: T
authors.lastname: Tanbo
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D001723:Birth Rate; D015331:Cohort Studies; D004715:Endometriosis / Q000150:complications*; D005184:Fallopian Tube Diseases / Q000150:complications*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000209:etiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D014427:Twins