Influence of carbon dioxide on the MIC of telithromycin for Streptococcus pneumoniae: an in vitro-in vivo study.
Incubation in CO(2) resulted in higher (> or =3 doubling dilution) MICs of telithromycin than those found in ambient air for 31.2% of 346 Streptococcus pneumoniae ermB-positive strains. An increased telithromycin MIC in CO(2) was not correlated with loss of its activity in the murine sepsis/peritonitis model.
Batard
Eric
E
Laboratoire d'Antibiologie, UER de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France. ebatard@chu-nantes.fr
Juvin
Marie Emmanuelle
ME
Jacqueline
Cédric
C
Bugnon
Denis
D
Caillon
Jocelyne
J
Potel
Gilles
G
Drugeon
Henri B
HB
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D002245:Carbon Dioxide / Q000494:pharmacology*; D004195:Disease Models, Animal; D006801:Humans; D048628:Ketolides / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000379:methods; D010538:Peritonitis / Q000188:drug therapy / Q000382:microbiology; D011008:Pneumococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D048628:Ketolides; D011500:Protein Synthesis Inhibitors; D002245:Carbon Dioxide; C106791:telithromycin