title: [An investigation on the percentages of TRAb-producing cells in Graves disease].
abstract: OBJECTIVE
  To investigate the presence of the TRAb-producing cell precursors in the cases of Graves disease.
  
  
  METHODS
  Peripheral lymphocytes were infected with Epstein-Barr virus, a kind of lymphocyte precursor stimulator, and were stimulated to produce TRAb.
  
  
  RESULTS
  The percentages of TRAb-producing cells from Graves disease group were obviously higher than those from healthy control group. The isotype of TRAb in The frequencies of supernants of these EBV-transformed B lymphocytes was predominatly IgM.
  
  
  CONCLUSIONS
  TRAb-specific precursors were higher in the cases of Graves disease than in healthy control.
authors.affiliation: Division of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Jia
authors.forename: Zhenmel
authors.initials: Z
authors.lastname: An
authors.forename: Decai
authors.initials: D
authors.lastname: Chen
authors.forename: Songquan
authors.initials: S
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000378:metabolism / Q000821:virology; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000276:immunology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors; D011989:Receptors, Thyrotropin / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007075:Immunoglobulin M; D011498:Protein Precursors; D011989:Receptors, Thyrotropin