Comparison between glycoprotein IIb/IIIa blockade and distal protection device for the restoration of myocardial perfusion during percutaneous coronary intervention for acute myocardial infarction.
We compared the use of abciximab with a distal balloon occlusion device in preserving myocardial perfusion among patients undergoing acute percutaneous coronary intervention for ST-segment elevation myocardial infarction. Of 114 patients, 40 were treated with abciximab and 74 with distal protection. Although pre-treatment with abciximab resulted in marginally better myocardial perfusion at initial coronary angiography, distal protection emerged superior at the end of the procedure. The use of distal protection was associated with an adjusted odds of 4 (p = 0.017) for achieving normal myocardial perfusion and adjusted reduction of 11 corrected TIMI frame counts (p = 0.001) compared with abciximab.
Mak
Koon-Hou
KH
National Heart Centre, Singapore. makkh001@yahoo.com
Phay
Corinna
C
Wong
Aaron
A
Kwok
Veronica
V
Tan
Kok-Soon
KS
Lau
Kean-Wah
KW
Koh
Tian-Hai
TH
D000077284:Abciximab; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D017023:Coronary Angiography; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D015607:Stents; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D000077284:Abciximab