Population-based prevalence and age distribution of human papillomavirus among women in Santiago, Chile.
More than 18 types of human papillomavirus (HPV) are associated with cervical cancer, the relative importance of the HPV types may vary in different populations.


OBJECTIVE
To investigate the types of HPV, age distribution, and risk factors for HPV infection in women from Santiago, Chile.


METHODS
We interviewed and obtained two cervical specimens from a population-based random sample of 1,038 sexually active women (age range, 15-69 years). Specimens were tested for the presence of HPV DNA using a GP5+/6+ primer-mediated PCR and for cervical cytologic abnormalities by Papanicolaou smears.


RESULTS
122 women tested positive for HPV DNA, 87 with high risk types (HR), and 35 with low risks (LR) only. Standardized prevalence of HPV DNA was 14.0% [95% confidence interval (95% CI), 11.5-16.4]. HR HPV by age showed a J reverse curve, whereas LR HPV showed a U curve, both statistically significant in comparison with no effect or with a linear effect. We found 34 HPV types (13 HR and 21 LR); HPV 16, 56, 31, 58, 59, 18, and 52 accounted for 75.4% of HR infections. Thirty-four (3.6%) women had cytologic lesions. Main risk factor for HPV and for cytologic abnormalities was number of lifetime sexual partners, odds ratios for > or =3 versus 1 were 2.8 (95% CI, 1.6-5.0) and 3.8 (95% CI, 1.3-11.4), respectively.


CONCLUSIONS
LR HPV presented a clear bimodal age pattern; HR HPV presented a J reverse curve. HPV prevalence was similar to that described in most Latin American countries.
Ferreccio
Catterina
C
Department of Public Health, School of Medicine, P Catholic University, Depto. de Salud Pública, Marcoleta, 434, Santiago, Santiago 6510259, Chile. cferrec@med.puc.cl
Prado
Rodrigo B
RB
Luzoro
Amaranta V
AV
Ampuero
Sandra Ll
SL
Snijders
Peter J F
PJ
Meijer
Chris J L M
CJ
Vaccarella
Salvatore V
SV
Jara
Alejandro T
AT
Puschel
Klaus I
KI
Robles
Sylvia C
SC
Herrero
Rolando
R
Franceschi
Silvia F
SF
Ojeda
Jose M
JM
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002677:Chile / Q000453:epidemiology; D004279:DNA, Viral / Q000032:analysis; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000235:genetics* / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000453:epidemiology*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D014505:Urban Population; D002583:Uterine Cervical Neoplasms / Q000821:virology; D014626:Vaginal Smears
D004279:DNA, Viral