Results of a phase I study to dose escalate using intensity modulated radiotherapy guided by combined PET/CT imaging with induction chemotherapy for patients with non-small cell lung cancer.
Intensity modulated radiation therapy (IMRT) guided by PET/CT imaging with respiratory gating was employed to dose escalate in patients with non-small cell lung cancer (NSCLC), using accelerated fractionation with induction chemotherapies. One patient developed a grade 5 pneumonitis and the study was halted at 84 Gy in 35 fractions.
Holloway
Caroline L
CL
Department of Radiation Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alta., Canada T6G 1Z2.
Robinson
Don
D
Murray
Brad
B
Amanie
John
J
Butts
Charles
C
Smylie
Michael
M
Chu
Karen
K
McEwan
A J
AJ
Halperin
Ross
R
Roa
Wilson H
WH
D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D017564:Radiation Pneumonitis; D014057:Tomography, X-Ray Computed