title: Hypereosinophilic syndrome: long-term remission following allogeneic stem cell transplant in spite of transient eosinophilia post-transplant.
abstract: A 38-year-old male with progressive myeloproliferative variant of hypereosinophilic syndrome (HES) underwent allogeneic bone marrow transplantation from a matched unrelated donor. The preparative regimen consisted of TBI, cytarabine, and cyclophosphamide. The graft was T-cell-depleted. The patient had slow, but complete, hematologic recovery, and all cells were shown by VNTR analysis to be of donor origin. Five months after transplant, the patient developed prominent eosinophilia (peak 4.1 x 10(9)/L) with dermatographism and very high IL-5 levels. Eosinophils isolated to purity by cell sorting were all of donor origin. Mild increase in immunosuppression led to a normalization of eosinophil count after about 6 months. The patient is now 6 years after transplant, off all medications, and without evidence of disease. Allogeneic stem-cell transplantation is a potentially curative therapy for HES.
authors.affiliation: Indiana Oncology-Hematology Consultants, Indianapolis, Indiana 46107, USA.
authors.forename: Maureen A
authors.initials: MA
authors.lastname: Cooper
authors.forename: Luke P
authors.initials: LP
authors.lastname: Akard
authors.forename: James M
authors.initials: JM
authors.lastname: Thompson
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Dugan
authors.forename: Jan
authors.initials: J
authors.lastname: Jansen
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004802:Eosinophilia / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000601:surgery*; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015848:Interleukin-5 / Q000097:blood; D008297:Male; D011184:Postoperative Period; D012074:Remission Induction; D013997:Time Factors; D014184:Transplantation, Homologous; D014581:Urticaria / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology
chemical_list: D007166:Immunosuppressive Agents; D015848:Interleukin-5; D003561:Cytarabine; D003520:Cyclophosphamide