Serum concentrations of interleukin-8, vascular endothelial growth factor, and epidermal growth factor receptor in patients with squamous cell cancer of the head and neck.
Squamous cell cancer of the head and neck (SCCHN) is associated with production of pro-inflammatory and pro-angiogenic cytokines. We hypothesized that cytokine serum levels will correlate with tumor volume and aggressiveness. We investigated interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) in SCCHN. The patient population consisted of normal and irradiated controls: patients with newly diagnosed SCCHN, and patients with recurrent or metastatic disease. Pretreatment sera were studied by ELISA. Serum IL-8 levels, as opposed to VEGF or EGFR, were consistently elevated in patients with recurrent or metastatic disease. The differences in mean serum IL-8, compared to controls, were significant (p=0.02). Serum levels of IL-8 are consistently elevated in patients with recurrent or metastatic SCCHN and elevated levels may correlate with advanced or aggressive disease. Further, more intensive, study of IL-8 as a biomarker in SCCHN is warranted.
Gokhale
Abhay S
AS
Human Monoclonal Antibody Laboratory, Division of Hematology-Oncology, Department of Medicine, Room 556, 21-27 Burlington Avenue, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Haddad
Robert I
RI
Cavacini
Lisa A
LA
Wirth
Lori
L
Weeks
Linda
L
Hallar
Melissa
M
Faucher
Jarrod
J
Posner
Marshall R
MR
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology / Q000556:secondary; D066246:ErbB Receptors / Q000097:blood; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000473:pathology; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood; D009364:Neoplasm Recurrence, Local / Q000097:blood; D009367:Neoplasm Staging; D010865:Pilot Projects; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
D014408:Biomarkers, Tumor; D016209:Interleukin-8; D009363:Neoplasm Proteins; D042461:Vascular Endothelial Growth Factor A; D066246:ErbB Receptors