[Radioactive iodine therapy in Graves' hyperthyroidism].
Graves' disease is the most frequent cause of hyperthyroidism. Clinical thyrotoxicosis is directly caused by autoantibodies that activate the TSH receptor. The etiology is multifactorial, with genetic and nongenetic factors involved. Current treatment options are antithyroid drugs (ATD), radioiodine (131I) and surgery. Radioactive iodine is increasingly being used as definitive therapy, because it long has proven to be a safe, nonexpensive and effective treatment. Recent publications have discussed the use of 131I associated with ATD as well as the identification of predictors of treatment failure, which are discussed in this review. Antithyroid drugs are still the first choice therapy in patients with mild disease, small goiters, children, adolescents, and in pregnancy. Surgery is now rarely performed. It is indicated only in cases where ATD have not been effective and radioiodine is contraindicated or not acceptable by the patients.
Andrade
Vânia A
VA
Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS.
Gross
Jorge Luiz
JL
Maia
Ana Luiza
AL
D006111:Graves Disease / Q000150:complications*; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology / Q000532:radiotherapy*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*
D007457:Iodine Radioisotopes