title: Micro-CT of carotid arteries: a tool for experimental studies.
abstract: Micro-computed tomography (micro-CT) is a high-resolution, non-destructive tool for two- and three-dimensional imaging and quantification. The ability of this technique to assess atherosclerosis of the carotid artery was evaluated in three human cadaver samples based on the original axial acquisitions, multiplanar reconstructions and volume rendering techniques. Quantitative analysis included the calculation of: (1) the original lumen perimeter, original lumen area, plaque area, residual lumen area, calcified area and gross sectional area reduction of the vascular lumen from two-dimensional slices; (2) the total tissue volume, soft tissue volume and calcified tissue volume from the three-dimensional data set. This preliminary study demonstrates the potential of micro-CT as a supplementary method for the two- and three-dimensional ex vivo evaluation of carotid atherosclerosis.
authors.affiliation: Department of Diagnostic Radiology, Christian Albrechts University of Kiel, Kiel, Germany. andreas.mohr@rad.uni-kiel.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Mohr
authors.forename: Ruediger
authors.initials: R
authors.lastname: Wenke
authors.forename: Frank W
authors.initials: FW
authors.lastname: Roemer
authors.forename: John A
authors.initials: JA
authors.lastname: Lynch
authors.forename: Christian
authors.initials: C
authors.lastname: Gatzka
authors.forename: Markus
authors.initials: M
authors.lastname: Priebe
authors.forename: Ali
authors.initials: A
authors.lastname: Guermazi
authors.forename: Mikayel
authors.initials: M
authors.lastname: Grigorian
authors.forename: Martin
authors.initials: M
authors.lastname: Heller
authors.forename: Stefan
authors.initials: S
authors.lastname: Mueller-Huelsbeck
mesh_terms: D000368:Aged; D001161:Arteriosclerosis / Q000000981:diagnostic imaging*; D002102:Cadaver; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D014057:Tomography, X-Ray Computed / Q000379:methods*