title: Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota.
abstract: The aim of the study was to assess the quantitative and qualitative differences of the gut microbiota in infants. We evaluated gut microbiota at the age of 6 months in 32 infants who were either exclusively breast-fed, formula-fed, nursed by a formula supplemented with prebiotics (a mixture of fructo- and galacto-oligosaccharides) or breast-fed by mothers who had been given probiotics. The Bifidobacterium, Bacteroides, Clostridium and Lactobacillus/Enterococcus microbiota were assessed by the fluorescence in situ hybridization, and Bifidobacterium species were further characterized by PCR. Total number of bifidobacteria was lower among the formula-fed group than in other groups (P=0.044). Total amounts of the other bacteria were comparable between the groups. The specific Bifidobacterium microbiota composition of the breast-fed infants was achieved in infants receiving prebiotic supplemented formula. This would suggest that early gut Bifidobacterium microbiota can be modified by special diets up to the age of 6 months.
authors.affiliation: The University of Turku, 20014 Turku, Finland; Department of Pediatrics, Turku University Central Hospital, 20520 Turku, Finland. minrin@utu.fi
authors.forename: Minna M
authors.initials: MM
authors.lastname: Rinne
authors.forename: Miguel
authors.initials: M
authors.lastname: Gueimonde
authors.forename: Marko
authors.initials: M
authors.lastname: Kalliomäki
authors.forename: Ulla
authors.initials: U
authors.lastname: Hoppu
authors.forename: Seppo J
authors.initials: SJ
authors.lastname: Salminen
authors.forename: Erika
authors.initials: E
authors.lastname: Isolauri
mesh_terms: D001439:Bacteroides / Q000302:isolation & purification; D001644:Bifidobacterium / Q000145:classification / Q000302:isolation & purification*; D001942:Breast Feeding; D003013:Clostridium / Q000302:isolation & purification; D015169:Colony Count, Microbial; D019587:Dietary Supplements; D016983:Enterococcus / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005387:Finland; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007225:Infant Food; D041943:Infant Formula; D007778:Lactobacillus / Q000302:isolation & purification; D009844:Oligosaccharides / Q000008:administration & dosage; D016133:Polymerase Chain Reaction
chemical_list: D009844:Oligosaccharides