title: Budesonide once versus twice-daily administration: meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to examine the efficacy of budesonide administered once daily compared to twice daily in asthma.
  
  
  METHODS
  Meta-analysis of randomised controlled trials comparing budesonide administered once versus twice a day that presented data on at least one clinical outcome measure was conducted.
  
  
  RESULTS
  A total of 10 studies, with 1922 children and adults with asthma, met the inclusion criteria. These studies were performed predominantly with mild to moderate asthmatic patients, using doses of budesonide ranging from 200 to 800 microg per day. There was no significant difference between daily dosing once or twice for all the clinical outcome variables, including withdrawals due to asthma, for which the odds ratio was 1.0 (95% confidence interval, 0.65-1.52).
  
  
  CONCLUSIONS
  In mild to moderate asthma a once-daily budesonide regimen has a similar efficacy to a twice-daily regimen in doses up to 800 microg per day. A once-daily regimen has potential advantages in terms of patient compliance and satisfaction, when used in clinical practice.
authors.affiliation: Medical Research Institute of New Zealand, Wellington, New Zealand.
authors.forename: Matthew
authors.initials: M
authors.lastname: Masoli
authors.forename: Mark
authors.initials: M
authors.lastname: Weatherall
authors.forename: Shaun
authors.initials: S
authors.lastname: Holt
authors.forename: Richard
authors.initials: R
authors.lastname: Beasley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D019819:Budesonide / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D016896:Treatment Outcome
chemical_list: D001993:Bronchodilator Agents; D019819:Budesonide