Around the world of DNA damage INO80 days.
DNA damage is detected and repaired in the context of chromatin. In this issue of Cell, van Attikum et al. (2004) and Morrison et al. (2004) demonstrate that double-stranded break repair involves the recruitment of a specialized chromatin remodeling complex, INO80, through an interaction with phosphorylated histone H2A.
Cairns
Bradley R
BR
Howard Hughes Medical Institute and Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
D000255:Adenosine Triphosphate / Q000235:genetics / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly / Q000235:genetics / Q000502:physiology; D002875:Chromosomes / Q000235:genetics* / Q000378:metabolism; D004249:DNA Damage / Q000235:genetics* / Q000502:physiology; D004260:DNA Repair / Q000235:genetics* / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D011485:Protein Binding; D051721:Rad52 DNA Repair and Recombination Protein; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology
D004268:DNA-Binding Proteins; C468783:H2AX protein, human; D006657:Histones; C483404:INO80 complex, S cerevisiae; C497197:RAD52 protein, S cerevisiae; D051721:Rad52 DNA Repair and Recombination Protein; D029701:Saccharomyces cerevisiae Proteins; D000255:Adenosine Triphosphate