title: Treatment of pediatric chronic pain with tramadol hydrochloride: siblings with Ehlers-Danlos syndrome - Hypermobility type.
abstract: OBJECTIVE
  To evaluate the effectiveness of tramadol hydrochloride for the treatment of chronic pain refractory to previous treatment in two pediatric patients.
  
  
  METHODS
  Tramadol hydrochloride was administered (50 mg/day to 150 mg/day) to two siblings with Ehlers-Danlos syndrome - Hypermobility type refractory to previous pharmacological treatments, and changes in pain intensity and physical activity were assessed.
  
  
  RESULTS
  Pain intensity decreased and physical activity improved within days of starting therapy. Positive results have been maintained for 30 months.
  
  
  CONCLUSIONS
  Tramadol hydrochloride was a safe and effective treatment for relieving chronic pain in two pediatric patients suffering from the hypermobility type of Ehlers-Danlos syndrome. No morbidity or side effects were noted during the 30-month follow-up.
authors.affiliation: Department of Anaesthesia, The Hospital for Sick Children, Toronto, Ontario. stephen.brown@sickkids.ca
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Brown
authors.forename: Jennifer
authors.initials: J
authors.lastname: Stinson
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004535:Ehlers-Danlos Syndrome / Q000150:complications*; D006801:Humans; D007593:Joint Instability / Q000209:etiology; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D014147:Tramadol / Q000008:administration & dosage*
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol