title: Using solution-phase nanoparticles, surface-confined nanoparticle arrays and single nanoparticles as biological sensing platforms.
abstract: The intense colors of noble metal nanoparticles have inspired artists and fascinated scientists for hundreds of years. In this review, we describe three sensing platforms based on the tunability of the localized surface plasmon resonance (LSPR) of gold and silver nanoparticles. Specifically, the color associated with solution-phase nanoparticles, surface-confined nanoparticle arrays, and single nanoparticles will be shown to be tunable and useful as platforms for biological sensing.
authors.affiliation: Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Haes
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Stuart
authors.forename: Shuming
authors.initials: S
authors.lastname: Nie
authors.forename: Richard P
authors.initials: RP
authors.lastname: Van Duyne
mesh_terms: D000465:Algorithms; D000906:Antibodies / Q000276:immunology; D001426:Bacterial Proteins / Q000032:analysis; D015374:Biosensing Techniques / Q000379:methods; D001710:Biotin / Q000031:analogs & derivatives* / Q000032:analysis / Q000276:immunology / Q000378:metabolism; D003124:Colorimetry; D006046:Gold / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D012834:Silver / Q000737:chemistry; D012996:Solutions / Q000737:chemistry; D013053:Spectrophotometry; D019809:Streptavidin / Q000032:analysis / Q000378:metabolism; D020349:Surface Plasmon Resonance / Q000379:methods*
chemical_list: D000906:Antibodies; D001426:Bacterial Proteins; D012996:Solutions; C066114:biotin-streptavidin complex; D012834:Silver; D001710:Biotin; D006046:Gold; D019809:Streptavidin