Enhancement of dissolution rate of poorly soluble active ingredients by supercritical fluid processes. Part II: Preparation of composite particles.
In this second of two articles, we show that several supercritical processes have been developed to prepare composite particles of poorly soluble active ingredients. Microencapsulation, cyclodextrin inclusion and impregnation allow to incorporate poorly soluble materials in fast-dissolving hydrophilic excipients, leading to promising results in terms of dissolution rate enhancement.
Perrut
M
M
SEPAREX, 5 Rue Jacques Monod, F-54250 Champigneulles, France. mperrut@separex.fr
Jung
J
J
Leboeuf
F
F
D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility
D004364:Pharmaceutical Preparations