[The CELO-ANG recombinant avian adenovirus with human angiogenine gene inducing neovascularization in the anterior tibial muscle of rat].
The CELO recombinant avian adenovirus carrying the gene coding the human angiogenine (ANG) synthesis was obtained. Expression of the angiogenine gene was shown in the LMH cell culture after infection with the CELO-ANG virus. The ability of CELO recombinant adenoviruses to carry out the delivery and expression of alien genes in muscle cells was demonstrated in experiments with laboratory animals (Wistar line rats). The induced neovascularization in rat muscles after the animals were administered the CELO-ANG viruses was shown.
Avdeeva
S V
SV
Voronov
D A
DA
Khaĭdarova
N V
NV
Shmarov
M M
MM
Logunov
D Iu
DIu
Cherenova
L V
LV
Verkhovskaia
L V
LV
Sheremet'eva
G F
GF
Gavrilenko
A V
AV
Tarantul
V Z
VZ
Naroditskiĭ
B S
BS
Bochkov
N P
NP
Konstantinov
B A
BA
Sverdlov
E D
ED
D043925:Angiogenesis Inducing Agents; D000818:Animals; D000259:Aviadenovirus / Q000235:genetics* / Q000378:metabolism; D002460:Cell Line; D015870:Gene Expression; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000378:metabolism; D018919:Neovascularization, Physiologic; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000096:biosynthesis; D012259:Ribonuclease, Pancreatic / Q000096:biosynthesis / Q000235:genetics; D013977:Tibia; D014162:Transfection
D043925:Angiogenesis Inducing Agents; D011994:Recombinant Proteins; C046366:angiogenin; D012259:Ribonuclease, Pancreatic