Early, selective growth hormone administration may ameliorate left ventricular remodeling after myocardial infarction.
Left ventricular (LV) remodeling after myocardial infarction (MI) may lead to congestive heart failure, disability and death. It consists of expansion of the infarct zone and dilatation of the non-infarcted myocardium, causing shape distortion and ventricular enlargement. Experimental studies have shown that treatment with growth hormone (GH) stimulates cardiac repair, resulting in increased infarct zone collagen scar formation and possibly enhanced proteinosynthesis. These actions may ameliorate the process of LV remodeling. We hypothesize that these beneficial effects may be more prominent, if GH is delivered selectively in the infarct area, during the early phase of acute MI. Experimental and clinical studies are necessary to validate this hypothesis.
Mitsi
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AC
Department of Cardiology, University of Ioannina, 1 University Avenue, University Campus, 45110 Ioannina, Epirus, Greece.
Hatzistergos
K
K
Baltogiannis
G G
GG
Kolettis
T M
TM
D000818:Animals; D004108:Dilatation, Pathologic / Q000503:physiopathology; D013006:Growth Hormone / Q000008:administration & dosage* / Q000494:pharmacology / Q000502:physiology*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D008954:Models, Biological; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology*
D013006:Growth Hormone