Nicotine augmentation for refractory obsessive-compulsive disorder. A case report.
The authors present a case of obsessive-compulsive disorder (OCD) resistant to conventional treatments, which improved following nicotine augmentation administered as 4 mg chewing gum. The role of acetylcholine in the pathophysiology of OCD is not clear. The authors discuss the effect of nicotine on memory for actions.
Pasquini
Massimo
M
Psychiatric Clinic III, University of Rome La Sapienza, Viale dell'Università, 30; 00185 Roma, Italy. maxpasquini@tiscalinet.it
Garavini
Alessandra
A
Biondi
Massimo
M
D000109:Acetylcholine / Q000502:physiology; D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D002997:Clomipramine / Q000627:therapeutic use; D004351:Drug Resistance; D018682:GABA Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009538:Nicotine / Q000627:therapeutic use*; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use
D000929:Antidepressive Agents, Tricyclic; D018682:GABA Agents; D018722:Nicotinic Agonists; D014635:Valproic Acid; D009538:Nicotine; D000109:Acetylcholine; D002997:Clomipramine