IV immunoglobulins as add-on treatment to methylprednisolone for acute relapses in MS.
OBJECTIVE
To investigate if IV immunoglobulins (IVIg) in combination with methylprednisolone make recovery from a relapse faster and more complete than methylprednisolone alone. Design/


METHODS
The authors studied 76 patients with multiple sclerosis (MS) who had an acute relapse with involvement of visual function, upper limb motor function, or gait, and with onset of symptoms between 24 hours and 14 days before. Patients were treated with either IVIg 1 g/kg or placebo (0.1% human albumin), given 24 hours before treatment with IV methylprednisolone 1 g on 3 consecutive days.


RESULTS
Both groups improved, but the authors observed no significant difference between IVIg and placebo patients regarding the primary endpoint, the mean change in the Z-score of the individually chosen targeted neurologic deficit (the most affected system) from baseline to 12 weeks (p = 0.89). A slightly better, but not significant remission was seen in the IVIg group in global scores, i.e., Expanded Disability Status Scale (p = 0.23) and Multiple Sclerosis Impairment Scale (p = 0.24), and in time to next relapse (p = 0.22).


CONCLUSIONS
The results do not justify routine application of IV immunoglobulins as add-on therapy to IV methylprednisolone in the treatment of acute multiple sclerosis attacks.
Sorensen
P Soelberg
PS
MS Research Unit, Department of Neurology 2082, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark. pss@rh.dk
Haas
J
J
Sellebjerg
F
F
Olsson
T
T
Ravnborg
M
M
D000328:Adult; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D015993:Life Tables; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy / Q000628:therapy*; D011597:Psychomotor Performance; D012008:Recurrence; D017211:Treatment Failure; D014792:Visual Acuity; D016138:Walking
D016756:Immunoglobulins, Intravenous; D008775:Methylprednisolone