title: Biotransformation of (+)-androst-4-ene-3,17-dione.
abstract: Fermentation of (+)-androst-4-ene-3,17-dione (1) with Curvularia lunata for 10 days yielded five oxidative and reductive metabolites, androsta-1,4-diene-3,17-dione (2), 17beta-hydroxyandrosta-1,4-dien-3-one (3), 11alpha-hydroxyandrost-4-ene-3,17-dione (4), 11alpha,17beta-dihydroxyandrost-4-en-3-one (5) and 15alpha-hydroxyandrosta-1,4-dien-17-one (6). The structures of these metabolites were elucidated on the basis of spectroscopic techniques. These microbially transformed products were assayed against the clinically important enzymes, tyrosinase and prolyl endopeptidase.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Sadia
authors.initials: S
authors.lastname: Sultan
authors.forename: Mahmmud Tareq Hassan
authors.initials: MT
authors.lastname: Khan
authors.forename: Amsha
authors.initials: A
authors.lastname: Yasin
authors.forename: Farzana
authors.initials: F
authors.lastname: Shaheen
authors.lastname: Atta-ur-Rahman
mesh_terms: D000735:Androstenedione / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D001203:Ascomycota / Q000378:metabolism*; D001711:Biotransformation; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D010936:Plant Extracts; D000735:Androstenedione