Natural-cycle in vitro fertilization combined with in vitro maturation of immature oocytes is a potential approach in infertility treatment.
OBJECTIVE
To describe pregnancies and live births that resulted from IVF of mature oocytes retrieved from dominant follicles in a natural cycle combined with in vitro maturation (IVM) of immature oocytes retrieved from small follicles.


METHODS
Case reports.


METHODS
McGill Reproductive Center, Royal Victoria Hospital, McGill University.


METHODS
Three women with normal ovaries or polycystic ovaries who underwent infertility treatment.


METHODS
Administration of s.c. hCG (10,000 IU) 36 hours before oocyte retrieval in a natural cycle. After aspiration of all follicles, mature oocytes were inseminated immediately; immature oocytes were matured in vitro, inseminated by intracytoplasmic sperm injection (ICSI), and then the embryos transferred.


METHODS
Pregnancy and live birth.


RESULTS
Three pregnancies (two live births and one ongoing at time of writing) were achieved after the combination of natural-cycle IVF with IVM after transfer of the resulting embryos.


CONCLUSIONS
Natural-cycle IVF combined with IVM might be a new approach to IVF treatment for women with various causes of infertility.
Chian
Ri-Cheng
RC
Department of Obstetrics and Gynecology, McGill Reproductive Center, Royal Victoria Hospital, Montreal, Quebec, Canada. ri-cheng.chian@muhc.mcgill.ca
Buckett
William M
WM
Abdul Jalil
Ahmad Kamal
AK
Son
Weon-Young
WY
Sylvestre
Camille
C
Rao
Durga
D
Tan
Seang Lin
SL
D000328:Adult; D002478:Cells, Cultured; D016922:Cellular Senescence; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D007279:Injections, Subcutaneous; D008597:Menstrual Cycle; D009865:Oocytes; D006080:Ovarian Follicle; D036801:Parturition; D011085:Polycystic Ovary Syndrome / Q000150:complications; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D020858:Tissue and Organ Harvesting
D006063:Chorionic Gonadotropin