title: Full-field ERG, multifocal ERG and multifocal VEP in patients with retinitis pigmentosa and residual central visual fields.
abstract: OBJECTIVE
  To evaluate (with three different electrophysiological methods) the residual retinal function in a selected group of patients with retinitis pigmentosa and remaining small central visual fields.
  
  
  METHODS
  Fourteen patients from several different genetic subgroups, who had been followed with visual acuity and visual field testing for periods up to 32 years, were examined. Ophthalmological examination included full-field electroretinography (ERG), multifocal electroretinography (mfERG) and multifocal visual evoked potential (mfVEP).
  
  
  RESULTS
  The ERGs were severely reduced in all patients. The mfERGs demonstrated the residual central retinal function in five of the patients. The mfVEPs showed measurable amplitudes centrally in most of the patients. The follow-up examinations demonstrated the slowly progressive course of the disease with preservation or only slight further loss of visual fields over a period of 7-32 years.
  
  
  CONCLUSIONS
  Patients with retinitis pigmentosa may not always follow the typical natural course with progressive loss of visual fields, which may in some patients remain unaffected over several decades. Multifocal ERG and mfVEP may be clinically useful for evaluating remaining visual function in these patients.
authors.affiliation: Department of Ophthalmology, University Hospital of Lund, Lund, Sweden. lotta.granse@telia.com
authors.forename: Lotta
authors.initials: L
authors.lastname: Gränse
authors.forename: Vesna
authors.initials: V
authors.lastname: Ponjavic
authors.forename: Sten
authors.initials: S
authors.lastname: Andréasson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004594:Electrophysiology; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012160:Retina / Q000503:physiopathology*; D012174:Retinitis Pigmentosa / Q000503:physiopathology*; D014786:Vision Disorders / Q000503:physiopathology; D014794:Visual Fields / Q000502:physiology*