Calcium and mitochondria: mechanisms and functions of a troubled relationship.
Mitochondria promptly respond to Ca(2+)-mediated cell stimulations with a rapid accumulation of the cation into the matrix. In this article, we review (i) the basic principles of mitochondrial Ca(2+) transport, (ii) the physiological/pathological role of mitochondrial Ca(2+) uptake, (iii) the regulatory mechanisms that may operate in vivo, and (iv) the new targeted Ca(2+) probes that allowed the "rediscovery" of these organelles in calcium signalling.
Bianchi
Katiuscia
K
Department of Experimental and Diagnostic Medicine and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, 44100 Ferrara, Italy.
Rimessi
Alessandro
A
Prandini
Andrea
A
Szabadkai
György
G
Rizzuto
Rosario
R
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport; D008928:Mitochondria / Q000378:metabolism*
D000255:Adenosine Triphosphate; D002118:Calcium