title: Bioinformatics research on inter-racial difference in drug metabolism I. Analysis on frequencies of mutant alleles and poor metabolizers on CYP2D6 and CYP2C19.
abstract: The enzyme activities of CYP2D6 and CYP2C19 show a genetic polymorphism, and the frequency of poor metabolizers (PMs) on these enzymes depends on races. In the present study, the frequencies of mutant alleles and PMs in each race were analyzed based on information from published studies, considering the genetic polymorphisms of CYP2D6 and CYP2C19 as the causal factors of racial and inter-individual differences in pharmacokinetics. As a result, it was shown that there were racial differences in the frequencies of each mutant allele and PMs. The frequencies of PMs on CYP2D6 are 1.9% of Asians and 7.7% of Caucasians, and those of PMs on CYP2C19 are 15.8% of Asians and 2.2% of Caucasians. Based on the results, it was suggested that there would be racial differences in the frequencies of PM subjects whose blood concentrations might be higher for drugs metabolized by these enzymes. Additionally, it was suggested that enzyme activities would vary according to the number of functional alleles even in subjects judged to be extensive metabolizers (EMs). In the bridging study, genetic information regarding CYP2D6 and CYP2C19 of the subjects will help extrapolate foreign clinical data to a domestic population.
authors.affiliation: Pharmacia.
authors.forename: Takako
authors.initials: T
authors.lastname: Shimizu
authors.forename: Hirohide
authors.initials: H
authors.lastname: Ochiai
authors.forename: Fredrik
authors.initials: F
authors.lastname: Asell
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimizu
authors.forename: Ryuta
authors.initials: R
authors.lastname: Saitoh
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Hama
authors.forename: Jun
authors.initials: J
authors.lastname: Katada
authors.forename: Munehiro
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Matsui
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Taki
authors.forename: Tsuguchika
authors.initials: T
authors.lastname: Kaminuma
authors.forename: Michiko
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Aida
authors.forename: Akira
authors.initials: A
authors.lastname: Ohashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Ozawa