title: Pathogenesis of esophageal rings in eosinophilic esophagitis.
abstract: Eosinophilic esophagitis and eosinophilic gastroenteritis is being recognized more frequently among the adult patients. The disease is characterized by massive infiltration of the wall of gastrointestinal tract by sheets of eosinophils. The clinical features depend upon the site of involvement. They include dyspepsia, dysphagia, nausea, vomiting, chest pain, diarrhea and protein-losing enteropathy. Eosinophilic esophagitis may present as chest pain, dysphagia or dyspepsia. The characteristic endoscopic feature of eosinophilic esophagitis is the formation of fine concentric mucosal rings (corrugated esophagus). Regarding the pathogenesis of these mucosal rings our hypothesis is that mast cells in the esophageal wall in response to allergens release histamine, eosinophilic chemotactic factor and platelet activating factor, etc. which activate eosinophils to release toxic cationic proteins. Activation of acetyl choline by histamine may cause contraction of the muscle fibers in the muscularis mucosae resulting in the formation of esophageal rings. This hypothesis can be tested by demonstrating the contraction of muscle layers of muscularis mucosae with the use of high frequency endoscopic ultrasonic probe introduced via the biopsy channel of an endoscope.
authors.affiliation: V.A. Medical Center, 150 Muir Road, Martinez, CA 94553, USA. frances.hill@med.va.gov
authors.forename: N S
authors.initials: NS
authors.lastname: Mann
authors.forename: J W
authors.initials: JW
authors.lastname: Leung
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000328:Adult; D000485:Allergens / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism / Q000633:toxicity; D002630:Chemotactic Factors / Q000378:metabolism; D004802:Eosinophilia / Q000209:etiology* / Q000503:physiopathology; D004804:Eosinophils / Q000378:metabolism; D004941:Esophagitis / Q000473:pathology* / Q000503:physiopathology*; D004947:Esophagus / Q000473:pathology; D005759:Gastroenteritis / Q000473:pathology / Q000503:physiopathology; D006632:Histamine / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D009119:Muscle Contraction; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D010972:Platelet Activating Factor / Q000378:metabolism
chemical_list: D000485:Allergens; D023181:Antimicrobial Cationic Peptides; D002630:Chemotactic Factors; D010972:Platelet Activating Factor; D006632:Histamine; D000109:Acetylcholine