title: [Investigation of pathogenic bacteria for pulmonary infections and their drug resistance in neurological intensive care unit].
abstract: OBJECTIVE
  To investigate the pathogenic bacterial spectrum responsible for pulmonary infections and their drug resistance in patients admitted to neurological care unit.
  
  
  METHODS
  Sputum specimens were obtained from patients who developed pulmonary infections in neurological intensive care unit between January, 2001 and June, 2002 for bacterial culture and isolation. K-B paper disc method was employed for determination of the drug sensitivity of the bacterial isolates.
  
  
  RESULTS
  In the 207 strains obtained from the patients, the majority (68.51%) were Gram-negative and 30.91/ Gram-positive bacteria, with fungi detected in one case (0.48%). The major pathogenic bacteria for pulmonary infection were, in the order of frequency, Staphylococcus aureus(14.49%), Pseudomonas aeruginosa (14.49%), Klebsiella pneumoniae (8.7%), Enterobacter cloacae (6.76%), and Enterobacter aerogenes (6.28%). Drug sensitivity tests showed increased drug resistance of the bacteria, but Staphylococcus aureus still remained sensitive to vancomycin and most of the Gram-negative bacillus sensitive to imipenem.
  
  
  CONCLUSIONS
  The major pathogenic bacteria causing pulmonary infections in neurological intensive care unit are Staphylococcus aureus and Pseudomonas aeruginosa, and their drug resistance is obviously increased, suggesting the necessity of strengthening bacterial surveillance and more adequate clinical use of antibiotics.
authors.affiliation: Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. shitaoyang@tom.com
authors.forename: Meng-yun
authors.initials: MY
authors.lastname: Shi
authors.forename: Hui-fang
authors.initials: HF
authors.lastname: Xie
authors.forename: Ji-peng
authors.initials: JP
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000150:complications; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D020300:Intracranial Hemorrhages / Q000150:complications; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011014:Pneumonia / Q000209:etiology / Q000382:microbiology*; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects*