Neuroleptic malignant syndrome and clozapine withdrawal at the same time?
The authors report a case of a patient, who in a few days after an abrupt discontinuation of clozapine and haloperidol developed agitated and confused state resembling neuroleptic malignant syndrome (NMS) and clozapine withdrawal symptoms at the same time. Data obtained from family members led to gradual reintroduction of clozapine and to subsequent recovery. The case illustrates the importance for clinicians to be familiar with the variety of discontinuation symptoms, so they can recognize them and offer effective treatment.
Margetić
Branimir
B
Neuropsychiatric Hospital Dr. Ivan Barbot, 44 317 Popovaca, Croatia. branimir.margetic@zg.htnet.hr
Aukst-Margetić
Branka
B
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects*; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000150:complications* / Q000523:psychology; D011595:Psychomotor Agitation / Q000209:etiology; D013375:Substance Withdrawal Syndrome / Q000150:complications* / Q000523:psychology; D016312:Treatment Refusal
D014150:Antipsychotic Agents; D003024:Clozapine; D006220:Haloperidol