title: Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection.
abstract: In recent years, a number of newer designer drugs have entered the illicit drug market. The methylenedioxy-derivates of amphetamine represent the largest group of designer drugs. This paper describes a method for screening for and quantification of ten 2,5-methylenedioxy-derivates of amphetamine and phenylethylamine in human urine, using capillary electrophoresis coupled to electrospray ionisation-mass spectrometry (CE-ESI-MS). Prior to CE-MS analysis, a simple solid-phase extraction (SPE) was used for sample cleanup. The method was validates according to international guidelines.
authors.affiliation: Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Italy. gboatto@uniss.it
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Boatto
authors.forename: Maria
authors.initials: M
authors.lastname: Nieddu
authors.forename: Antonio
authors.initials: A
authors.lastname: Carta
authors.forename: Amedeo
authors.initials: A
authors.lastname: Pau
authors.forename: Michele
authors.initials: M
authors.lastname: Palomba
authors.forename: Battistina
authors.initials: B
authors.lastname: Asproni
authors.forename: Riccardo
authors.initials: R
authors.lastname: Cerri
mesh_terms: D000662:Amphetamines / Q000652:urine*; D015198:Designer Drugs / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
chemical_list: D000662:Amphetamines; D015198:Designer Drugs