Non-metazoan class III nucleotidyl cyclases: novel forms and functions.
Nucleotidyl cyclases synthesize cAMP or cGMP in response to various forms of sensory input. Their regulation and function in mammalian hormone action and neurotransmission has been well characterized over the past 40 years. More recently a much broader repertoire of adenylyl- and guanylyl cyclase forms is emerging from studies of more basal eukaryotes and prokaryotes. These cyclases play crucial roles in the development, physiology and pathogenicity of these organisms. This series of reviews highlights both unique and highly conserved aspects of the activation mechanisms of these enzymes, as compared to those of their mammalian descendants.
Schaap
Pauline
P
School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. p.schaap@dundee.ac.uk
D000262:Adenylyl Cyclases / Q000502:physiology*; D000242:Cyclic AMP / Q000096:biosynthesis*; D006162:Guanylate Cyclase / Q000502:physiology*
D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase