The febrile response to intraperitoneal lipopolysaccharide: strain and gender differences in rats.
The acute-phase febrile responses of the inbred Lewis (LEW) and Fischer 344 (F344) rat strains and their parent Sprague-Dawley (S-D) strain to immune challenge with lipopolysaccharide (LPS) were compared. LEW and S-D males and females displayed a biphasic febrile response with a markedly attenuated second phase in F344 rats. At 2 h after LPS (50 microg/kg), corticosterone was significantly higher in F344 than in LEW rats, but serum interleukin-1beta was higher only in F344 than LEW males. These data suggest that the greater LPS-induced corticosterone response of F344 rats mediates differences between febrile responses of F344 and LEW males and females.
Taylor
Anna N
AN
Department of Neurobiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095-1763, USA. ataylor@mednet.ucla.edu
Tio
Delia L
DL
Romeo
Horacio E
HE
D000704:Analysis of Variance; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005334:Fever / Q000097:blood / Q000139:chemically induced* / Q000235:genetics / Q000503:physiopathology; D007274:Injections, Intraperitoneal / Q000379:methods; D007375:Interleukin-1 / Q000097:blood; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D011863:Radioimmunoassay / Q000379:methods; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D013045:Species Specificity; D013997:Time Factors
D007375:Interleukin-1; D008070:Lipopolysaccharides; D003345:Corticosterone