title: The genotoxic effect of the new acaricide etoxazole.
abstract: Etoxazole is a member of the diphenyl oxazoline class of insecticide was newly developed for use on pome fruits, cotton and strawberries as a acaricide. In the present study, genotoxic effects of acaricide etoxazole (ETX) (miticide/ovicide) were investigated using chromosome aberration (CA) test, sister chromatid exchange (SCE) test and micronucleus test in human lymphocytes. ETX induced the CAs at all concentrations (5, 10 and 20 microg/ml) for 24 h and also induced the CA at the highest concentration (20 microg/ml) for 48 h only. The inducing the CAs for 48 hours treatment period was dose-dependent. Besides, it induced the SCE at all concentrations and treatment periods in a dose-dependent manner as well. Although, ETX decreased the mitotic index (MI) at all concentration and treatment periods dose-dependently, while it did not decrease the replication index (RI) when compared to the negative and solvent controls. In addition, ETX induced the micronucleus at all concentrations except 5 microg/ml for 48 h. This inducing was in a dose-dependent manner as well. In conclusion, it can be concluded that ETX has a potential genotoxic effects in cultured human peripheral lymphocytes.
authors.affiliation: Cukurova University, Faculty of Arts and Sciences, Department of Biology, Adana 01330, Turkey. reyyup@mail.cu.edu.tr
authors.forename: Eyyüp
authors.initials: E
authors.lastname: Rencüzoğullari
authors.forename: Hasan Basri
authors.initials: HB
authors.lastname: Ila
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kayraldiz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Arslan
authors.forename: Songül Budak
authors.initials: SB
authors.lastname: Diler
authors.forename: Mehmet
authors.initials: M
authors.lastname: Topaktaş
mesh_terms: D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D012854:Sister Chromatid Exchange
chemical_list: D007306:Insecticides; D009153:Mutagens