[Study on cellular immunity in children with respiratory syncytial virus associated acute lower respiratory infection].
For exploring cellular immunity disturbances in children with acute lower respiratory infection (ALRI) caused by respiratory syncytial virus (RSV) the level of interleukin-2 (IL-2) soluble interleukin-2 receptor (sIL- 2R), the expression rate of interleukin-2 receptor (IL-2R) on T cells and percentage of T lymphocyte subsets were determined in peripheral blood of 25 acute cases. The results showed that compared acute stage of RSV associated ALRI with recovery stage and control group, the level of peripheral blood IL-2 and expression rates of IL-2R decreased but the level of sIL-2R increased. The level of IL-2 had positive correlation with IL-2R and percentage of CD4+ cells, but had negative correlation with sIL-2R and percentage of CD8+ cells. The plasma sIL-2R level had negative correlation with expression rate of IL-2R, but had a positive correlation with clinical severity. These results suggested that human body had a functional disturbance in cellular immunity when infected with RSV.
Chen
Z
Z
Department of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan 430030.
Dong
Y
Y
Zhang
M
M
Li
G
G
D000208:Acute Disease; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D015375:Receptors, Interleukin-2 / Q000097:blood; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology
D007376:Interleukin-2; D015375:Receptors, Interleukin-2