title: The effects of sodium cromoglycate on antigen inhalation challenge in two horses affected with chronic obstructive pulmonary disease (COPD).
abstract: 80 mg sodium cromoglycate (SCG) was administered by inhalation to two COPD-affected animals known to have respiratory hypersensitivity to Micropolyspora faeni. SCG treatment 20-30 minutes prior to inhalation challenge with M. faeni prevented exacerbation of respiratory disease, usually seen 4-8 hours after challenge. duration of protection against antigen challenge after a single SCG treatment was 4-5 days. The duration of protection was not prolonged by reducing the frequency of antigen challenge. Multiple antigen challenge, using M. faeni and Aspergillus fumigatus, shortened the protective period of SCG to 3 days.
authors.affiliation: Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Great Britain.
authors.forename: J R
authors.initials: JR
authors.lastname: Murphy
authors.forename: E A
authors.initials: EA
authors.lastname: McPherson
authors.forename: G H
authors.initials: GH
authors.lastname: Lawson
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001232:Aspergillus fumigatus / Q000276:immunology; D001985:Bronchial Provocation Tests / Q000662:veterinary; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy* / Q000276:immunology*; D006736:Horses; D008297:Male; D008848:Micromonosporaceae / Q000276:immunology; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000276:immunology / Q000662:veterinary*
chemical_list: D018927:Anti-Asthmatic Agents; D004205:Cromolyn Sodium