Serum leptin elevation in obese women with PCOs: a continuing controversy.
OBJECTIVE
To evaluate leptin levels in a sample of obese women with PCOS and compare the results with obese and non-obese control, to be ultimately correlated with BMI, and insulin sensitivity.


METHODS
Leptin and insulin assays by immuno-radiometric method, glucose assay by enzymatic colorimetric method.


RESULTS
Leptin levels were significantly different between obese and non-obese subjects, and were significantly different between insulin resistant and non-insulin resistant obese PCOS, but were not significantly different between obese non-insulin resistant PCOS, and obese controls.


CONCLUSIONS
Body mass index and insulin resistance are the two main factors governing serum leptin levels.
Saleh
Hisham Ali
HA
Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. hishamsaleh@link.net
El-Nwaem
Mohamed Amr
MA
El-Bordiny
Magdy Mamdouh
MM
Maqlad
Hala Mohamed El-Sayed
HM
El-Mohandes
Amr Ahmed
AA
Eldaqaq
Ebtehag Mohamed
EM
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000097:blood*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000150:complications*
D007004:Hypoglycemic Agents; D007328:Insulin; D020738:Leptin