A new polymer-supported reagent for the synthesis of beta-lactams in solution.
A modified Mukaiyama reagent was prepared on a PS-DVB resin. This reagent was used for the preparation of beta-lactams, using the Staudinger reaction. The products were obtained by generating the ketene from a carboxylic acid under sonication with the resin followed by reaction with the imine. Excess of the imine was removed by reduction followed by acid scavenging.
Donati
Donato
D
Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy.
Morelli
Costanza
C
Porcheddu
Andrea
A
Taddei
Maurizio
M
D007202:Indicators and Reagents / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012996:Solutions; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D011108:Polymers; D012996:Solutions; D047090:beta-Lactams