Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part II: comparison with cine magnetic resonance imaging.
OBJECTIVE
To compare manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging (MRI) with cine MRI for distinguishing the dysfunctional myocardium from the normal myocardium.


METHODS
Seventeen cats were prepared for acute myocardial infarction with 90 minutes of occlusion followed by 120 minutes of reperfusion. In vivo inversion-recovery gradient-recalled echo MRI and cine MRI were performed. Two radiologists independently analyzed the MR images and recorded the size of the unenhanced area on the MnDPDP-enhanced MR images as well as that of the dysfunctional area on the cine MR images. Agreement between these abnormal areas was evaluated using Bland-Altman analysis. Interobserver agreement was assessed using Bland-Altman analysis.


RESULTS
The sizes of the unenhanced area on the MnDPDP-enhanced MR images and the dysfunctional area on the cine MR images showed good agreement on Bland-Altman analysis (the limits of agreement: observer 1= 1.8% +/- 11.6, observer 2 = 0.1% +/- 9.9). The abnormal segments on both types of MR imaging showed a good interobserver agreement (the limits of agreement: MnDPDP-enhanced MRI = 0.3% +/- 7.6, cine MRI = -1.4% +/- 10.9).


CONCLUSIONS
The size of the dysfunctional area on the cine MR images was well correlated with that of the unenhanced area on the MnDPDP-enhanced MR images.
Yang
Dong Hyun
DH
Department of Radiology, Ulsan University College of Medicine, Seoul, Korea.
Kim
Tae Hoon
TH
Choi
Jin Woo
JW
Kim
Sang Tae
ST
Yoon
Jin Ho
JH
Shin
Ji Hoon
JH
Seo
Joon Beom
JB
Lim
Tae-Hwan
TH
D000208:Acute Disease; D000818:Animals; D002415:Cats; D003287:Contrast Media; D004195:Disease Models, Animal; D004492:Edetic Acid / Q000031:analogs & derivatives*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis*; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*
D003287:Contrast Media; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid