An antibody to VacA of Helicobacter pylori in the CSF of patients with Miller-Fisher syndrome.
The authors examined antibodies against native vacuolating cytotoxin (VacA) of Helicobacter pylori in CSF from 12 patients with Miller-Fisher syndrome (MFS). The VacA protein was separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting analysis was carried out. Eight of 12 MFS patients had a specific immunoglobulin G antibody against VacA in the CSF. There is sequence homology between VacA and some membrane ion transport proteins, raising the possibility that A-VacA-Ab involves the ion channels in the node of Ranvier in some patients with MFS.
Chiba
S
S
Department of Neurology, School of Medicine, Sapporo Medical University, Minami 1-Jo Nishi 16 chome, Chuo-ku, Sapporo 060-8543, Japan. chiba@sapmed.ac.jp
Sugiyama
T
T
Yonekura
K
K
Tanaka
S
S
Matsumoto
H
H
Fujii
N
N
Yokota
S
S
Hirayama
T
T
D000328:Adult; D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid* / Q000276:immunology; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D005260:Female; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000134:cerebrospinal fluid / Q000276:immunology*; D018716:Molecular Mimicry; D021122:Protein Subunits; D011901:Ranvier's Nodes / Q000276:immunology; D000254:Sodium-Potassium-Exchanging ATPase / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D021122:Protein Subunits; C074689:VacA protein, Helicobacter pylori; D000254:Sodium-Potassium-Exchanging ATPase