Hemolytic effects of water-soluble fullerene derivatives.
A series of water-soluble fullerene C(60) derivatives has been investigated for their cytotoxic and hemolytic properties, with the aim to correlate structure with toxicity. We observed that cationic chains induce significant toxicity while the presence of neutral or anionic moieties did not produce any response in our model. A validation of these experimental observations has been performed by theoretical studies in which hydrophilic and hydrophobic surface areas were correlated quantitatively with hemolytic properties.
Bosi
Susanna
S
Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa, 1-34127 Trieste, Italy.
Feruglio
Luigi
L
Da Ros
Tatiana
T
Spalluto
Giampiero
G
Gregoretti
Barbara
B
Terdoslavich
Michela
M
Decorti
Giuliana
G
Passamonti
Sabina
S
Moro
Stefano
S
Prato
Maurizio
M
D002470:Cell Survival / Q000187:drug effects; D037741:Fullerenes / Q000737:chemistry / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D012995:Solubility
D037741:Fullerenes; C069837:fullerene C60