Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a cat model: part I: comparison with pathologic examination.
OBJECTIVE
To investigate the capacity of manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging (MRI) to discriminate the injured myocardium from the normal myocardium in a cat model.


METHODS
Fourteen cats were prepared for acute myocardial infarction with 90-minute occlusion followed by 120-minute reperfusion. Inversion recovery gradient-recalled echo (IR-GRE) MR images were obtained at 60-minute intervals for 4 hours after the injection of MnDPDP, and ex vivo after the cats were killed. We evaluated the differences between the unenhanced area on the in vivo and ex vivo MR images and the unstained area on triphenyl tetrazolium chloride (TTC) staining.


RESULTS
The unenhanced area on the in vivo MR images was well correlated with that on the ex vivo MR images. The unenhanced area on the ex vivo MR images was significantly larger than the unstained area on TTC staining.


CONCLUSIONS
This study suggests that the MnDPDP-unenhanced area on the MR images includes not only the infarcted myocardium but also the stunned myocardium.
Kim
Tae Hoon
TH
Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.
Yang
Dong Hyun
DH
Choi
Jin Woo
JW
Kim
Sang Tae
ST
Yoon
Jin Ho
JH
Shin
Ji Hoon
JH
Seo
Joon Beom
JB
Gong
Gyung Yub
GY
Lim
Tae-Hwan
TH
D000208:Acute Disease; D000818:Animals; D002415:Cats; D003287:Contrast Media; D004195:Disease Models, Animal; D004492:Edetic Acid / Q000031:analogs & derivatives*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis* / Q000473:pathology; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*
D003287:Contrast Media; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid