TAT conjugated, FITC doped silica nanoparticles for bioimaging applications.
Water-in-oil (w/o) microemulsion synthesis of 70 nm size monodisperse TAT (a cell penetrating peptide, CPP) conjugated, FITC (fluorescein isothiocyanate) doped silica nanoparticles (TAT-FSNPs) is reported; human lung adenocarcinoma (A549) cells (in vitro) and rat brain tissue (in vivo) were successfully labeled using TAT-FSNPs.
Santra
Swadeshmukul
S
Department of Neurological Surgery, University of Florida, PO Box 100265, Gainesville, FL 32610, USA. santra@neurosurgery.ufl.edu
Yang
Heesun
H
Dutta
Debamitra
D
Stanley
Jessie T
JT
Holloway
Paul H
PH
Tan
Weihong
W
Moudgil
Brij M
BM
Mericle
Robert A
RA
D000818:Animals; D001921:Brain / Q000378:metabolism; D045744:Cell Line, Tumor; D004655:Emulsions / Q000737:chemistry; D016650:Fluorescein-5-isothiocyanate / Q000032:analysis* / Q000737:chemistry*; D015696:Gene Products, tat / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D051381:Rats; D012822:Silicon Dioxide / Q000737:chemistry*
D004655:Emulsions; D015696:Gene Products, tat; D012822:Silicon Dioxide; D016650:Fluorescein-5-isothiocyanate