title: Phostoxin-induced biochemical and pathomorphological changes in rabbits.
abstract: The effect of chronic phostoxin administration on some tissue ATPases, hematology and tissue histopathology was investigated using a combination of gravimetric, enzymatic, colorimetric and histological procedures in New Zealand White rabbits after 2 weeks administration of 0.8mg phostoxin/kg body weight/day, po. The phostoxin treatment led to significant decreases in Na(+)-K+ ATPase activities in renal, hepatic and cardiac tissues. Similar decreases were obtained in the activities of Ca(2+)-ATPase and Mg(2+)-ATPase in liver. In addition, the phostoxin-toxified rabbits manifested significant decreases in hematocrit, red blood cell count, hemoglobin and platelets. Histological examination of the tissues revealed pronounced degenerative changes in liver, heart and kidney.
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Benin, Benin City, Nigeria. ajino@uniben.edu
authors.forename: Ngozi Paulinus
authors.initials: NP
authors.lastname: Okolie
authors.forename: Jonathan Umezuluike
authors.initials: JU
authors.lastname: Aligbe
authors.forename: Edorisiagbon Eguagu
authors.initials: EE
authors.lastname: Osakue
mesh_terms: D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D004906:Erythrocyte Count; D006321:Heart / Q000187:drug effects / Q000502:physiology; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D010575:Pesticides / Q000633:toxicity*; D010720:Phosphines / Q000633:toxicity*; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity
chemical_list: D017607:Aluminum Compounds; D010575:Pesticides; D010720:Phosphines; D014874:Water Pollutants, Chemical; C001864:aluminum phosphide; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase