Site-selective Pd-catalyzed coupling of 1,4-diiodo-1,3-alkadienes with Grignard reagents and its application to the synthesis of fulvenes.
[reaction: see text] The coupling reaction of 1,4-diiodo-1,3-alkadienes with a Grignard reagent in the presence of a catalytic amount of Pd(PPh3)4 proceeded with excellent site-selectivity. Synthetic application of the reaction was demonstrated by a regio- and stereoselective synthesis of 1,3,6-trisubstituted fulvenes.
Uemura
Minoru
M
Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.
Takayama
Yuuki
Y
Sato
Fumie
F