title: [The role of the complement system in the defence against infections and new ways of assessing the activation routes].
abstract: The complement system is of major importance in the defence against infections. Deficiencies in one of the three pathways of activation of the complement system can cause serious infections; the classical pathway, the alternative pathway and the lectin pathway. A new ELISA assay has been developed to enable the assessment of the functional activity of the whole lectin pathway and to determine the classical and the alternative pathway functional activity in a simple uniform design.
authors.affiliation: Leids Universitair Medisch Centrum, afd. Nierziekten, C3P-29, Albinusdreef 2, 2333 ZA Leiden. majseelen@lumc.nl
authors.forename: M A
authors.initials: MA
authors.lastname: Seelen
authors.forename: L A
authors.initials: LA
authors.lastname: Trouw
authors.forename: A
authors.initials: A
authors.lastname: Daha
authors.forename: A
authors.initials: A
authors.lastname: Roos
mesh_terms: D001424:Bacterial Infections / Q000276:immunology*; D003167:Complement Activation / Q000276:immunology* / Q000502:physiology*; D003170:Complement Pathway, Alternative / Q000276:immunology / Q000502:physiology; D003171:Complement Pathway, Classical / Q000276:immunology / Q000502:physiology; D037582:Complement Pathway, Mannose-Binding Lectin / Q000276:immunology / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans