title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
abstract: In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identifed 1445 putative TFs in the mouse genome. We used in situ hybridization to map the expression of over 1000 of these TFs and TF-coregulator genes in the brains of developing mice. We found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain. We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.
authors.affiliation: Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Gray
authors.forename: Hui
authors.initials: H
authors.lastname: Fu
authors.forename: Ping
authors.initials: P
authors.lastname: Luo
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.forename: Annette
authors.initials: A
authors.lastname: Ferrari
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Tenzen
authors.forename: Dong-In
authors.initials: DI
authors.lastname: Yuk
authors.forename: Eric F
authors.initials: EF
authors.lastname: Tsung
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Cai
authors.forename: John A
authors.initials: JA
authors.lastname: Alberta
authors.forename: Le-Ping
authors.initials: LP
authors.lastname: Cheng
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Jan M
authors.initials: JM
authors.lastname: Stenman
authors.forename: M Todd
authors.initials: MT
authors.lastname: Valerius
authors.forename: Nathan
authors.initials: N
authors.lastname: Billings
authors.forename: Haesun A
authors.initials: HA
authors.lastname: Kim
authors.forename: Michael E
authors.initials: ME
authors.lastname: Greenberg
authors.forename: Andrew P
authors.initials: AP
authors.lastname: McMahon
authors.forename: David H
authors.initials: DH
authors.lastname: Rowitch
authors.forename: Charles D
authors.initials: CD
authors.lastname: Stiles
authors.forename: Qiufu
authors.initials: Q
authors.lastname: Ma
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism*; D003001:Cloning, Molecular; D003342:Corpus Striatum / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D017931:DNA Primers; D016208:Databases, Factual; D020869:Gene Expression Profiling; D016678:Genome; D007031:Hypothalamus / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D017403:In Situ Hybridization; D008636:Mesencephalon / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D051379:Mice; D019579:Neocortex / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D016133:Polymerase Chain Reaction; D012249:Rhombencephalon / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D013116:Spinal Cord / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D013788:Thalamus / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*
chemical_list: D017931:DNA Primers; D014157:Transcription Factors