title: SilkDB: a knowledgebase for silkworm biology and genomics.
abstract: The Silkworm Knowledgebase (SilkDB) is a web-based repository for the curation, integration and study of silkworm genetic and genomic data. With the recent accomplishment of a approximately 6X draft genome sequence of the domestic silkworm (Bombyx mori), SilkDB provides an integrated representation of the large-scale, genome-wide sequence assembly, cDNAs, clusters of expressed sequence tags (ESTs), transposable elements (TEs), mutants, single nucleotide polymorphisms (SNPs) and functional annotations of genes with assignments to InterPro domains and Gene Ontology (GO) terms. SilkDB also hosts a set of ESTs from Bombyx mandarina, a wild progenitor of B.mori, and a collection of genes from other Lepidoptera. Comparative analysis results between the domestic and wild silkworm, between B.mori and other Lepidoptera, and between B.mori and the two sequenced insects, fruitfly and mosquito, are displayed by using B.mori genome sequence as a reference framework. Designed as a basic platform, SilkDB strives to provide a comprehensive knowledgebase about the silkworm and present the silkworm genome and related information in systematic and graphical ways for the convenience of in-depth comparative studies. SilkDB is publicly accessible at http://silkworm.genomics.org.cn.
authors.affiliation: College of Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Qingyou
authors.initials: Q
authors.lastname: Xia
authors.forename: Ximiao
authors.initials: X
authors.lastname: He
authors.forename: Mingtao
authors.initials: M
authors.lastname: Dai
authors.forename: Jue
authors.initials: J
authors.lastname: Ruan
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Guo
authors.initials: G
authors.lastname: Yu
authors.forename: Haifeng
authors.initials: H
authors.lastname: Yuan
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Hu
authors.forename: Ruiqiang
authors.initials: R
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Chen
authors.initials: C
authors.lastname: Ye
authors.forename: Cheng
authors.initials: C
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Songgang
authors.initials: S
authors.lastname: Li
authors.forename: Gane Ka-Shu
authors.initials: GK
authors.lastname: Wong
authors.forename: Huanming
authors.initials: H
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Zhonghuai
authors.initials: Z
authors.lastname: Xiang
authors.forename: Zeyang
authors.initials: Z
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
mesh_terms: D000818:Animals; D012831:Bombyx / Q000235:genetics* / Q000502:physiology; D030561:Databases, Nucleic Acid; D023281:Genomics; D020407:Internet; D007915:Lepidoptera / Q000235:genetics; D014584:User-Computer Interface