title: Topical application of Bifidobacterium-fermented soy milk extract containing genistein and daidzein improves rheological and physiological properties of skin.
abstract: The authors examined the effects of Bifidobacterium-fermented soy milk extract (BE) containing genistein and daidzein on the hyaluronic acid (HA) content and rheological and physiological properties of hairless mouse and/or human skin. Topical application of BE for six weeks significantly restored changes in the elasticity and viscoelasticity of mouse skin, increased the HA content, and hydrated and thickened mouse skin. Also, topical application of a gel formula containing 10% BE to the human forearm for three months significantly lessened the decrease in skin elasticity. Therefore, BE is expected to become a new cosmetic ingredient to prevent the loss of skin elasticity through enhancement of HA production.
authors.affiliation: Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo.
authors.forename: Kouji
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hanamizu
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sone
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Chiba
authors.forename: Takashi
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoshikawa
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000818:Animals; D001644:Bifidobacterium / Q000378:metabolism*; D004548:Elasticity; D005260:Female; D005285:Fermentation; D019833:Genistein / Q000008:administration & dosage*; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism; D007529:Isoflavones / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D041942:Soy Milk / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007529:Isoflavones; C004742:daidzein; D006820:Hyaluronic Acid; D019833:Genistein