title: New aspects on the preparation of [11C]Methionine--a simple and fast online approach without preparative HPLC.
abstract: At present, most data available on PET imaging of brain tumors using amino acids are based on l-[S-methyl-11C]methionine (MET). This radiopharmaceutical accurately delineates tumor extent, sometimes even better than CT. Since MET is playing such an important role for PET, a potent preparation method for this radiotracer allowing frequent syntheses for PET routine is desirable. Therefore, a simple disposable synthesis module was conceived without HPLC purification. Using a solid supported [11C]methylation on Al2O3 leads to the simplification of the preparation requiring only filtration for separation of precursor and MET. The presented method is able to produce high purity MET in excellent yields enough to serve several consecutive patients.
authors.affiliation: Department of Nuclear Medicine, Medical University of Vienna, AKH Wien, Waehringer Guertel 18-20, Vienna A-1090, Austria. markus.mitterhauser@akh-wien.ac.at
authors.forename: Markus
authors.initials: M
authors.lastname: Mitterhauser
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wadsak
authors.forename: Andreas
authors.initials: A
authors.lastname: Krcal
authors.forename: Joern
authors.initials: J
authors.lastname: Schmaljohann
authors.forename: Harald
authors.initials: H
authors.lastname: Eidherr
authors.forename: Alexander
authors.initials: A
authors.lastname: Schmid
authors.forename: Helmut
authors.initials: H
authors.lastname: Viernstein
authors.forename: Robert
authors.initials: R
authors.lastname: Dudczak
authors.forename: Kurt
authors.initials: K
authors.lastname: Kletter
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes / Q000737:chemistry*; D006801:Humans; D007553:Isotope Labeling; D008715:Methionine / Q000138:chemical synthesis*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D008715:Methionine