Leukemia inhibitory factor is a proliferative factor for olfactory sensory neurons.
Neuropoietic cytokines are known to play crucial roles in neuronal development. Among them, leukemia inhibitory factor (LIF) has been implicated in various processes of neuronal development, such as neuronal differentiation, survival and neurogenesis. Moreover, LIF is highly expressed in regions of the central nervous system where adult neurogenesis occurs. LIF was tested for its efficacy in promoting postnatal neurogenesis using LIF-null mice and dissociated cultures of early postnatal rat olfactory sensory neurons. Our results indicate that LIF promoted proliferation of olfactory sensory neuron precursors both in vivo and in vitro. In addition, LIF did not affect proliferation of non-neuronal cells. LIF may therefore be useful when developing stem cell therapy to replace damaged olfactory sensory neurons as well as a therapeutic agent to treat some anosmic symptoms.
Kim
Esther J
EJ
Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Simpson
Phyllis J
PJ
Park
Dong-Joon
DJ
Liu
Bridget Q
BQ
Ronnett
Gabriele V
GV
Moon
Cheil
C
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology; D007150:Immunohistochemistry; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; D051379:Mice; D018345:Mice, Knockout; D009475:Neurons, Afferent / Q000502:physiology*; D009833:Olfactory Pathways / Q000502:physiology*; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D018121:Receptors, Cytokine / Q000235:genetics / Q000502:physiology; D053606:Receptors, OSM-LIF
D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; C507838:Lif protein, mouse; C507841:Lifr protein, mouse; C507842:Lifr protein, rat; D011506:Proteins; D018121:Receptors, Cytokine; D053606:Receptors, OSM-LIF