title: [Custom moldable hydroxyapatite collagen composite for repair of osseous defects].
abstract: OBJECTIVE
  In the following study we evaluated the biological response of a new freely moldable bone substitute in an animal model.
  
  
  METHODS
  Critically sized defects were created surgically in the lower jaw of ten adult minipigs. The drill defects were filled with hydroxyapatite collagen paste. After observation periods of 1, 3, 6, 12, and 18 months the mandibles were harvested without wound healing defects for histological evaluation of resorption and bone ingrowth with a sawing and grinding technique.
  
  
  RESULTS
  The result of the remodeling process was a complete degradation of hydroxyapatite collagen implants after 12-18 months with reorganization of vital trabeculae oriented in a mature pattern.
  
  
  CONCLUSIONS
  The hydroxyapatite collagen cement works as an osteoconductor and shows signs of direct osseointegration and resorption.
authors.affiliation: Klinik für Mund-, Kiefer- und Gesichtschirurgie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden. Ronald.Mai@mailbox.tu-dresden.de
authors.forename: R
authors.initials: R
authors.lastname: Mai
authors.forename: A
authors.initials: A
authors.lastname: Reinsdorf
authors.forename: E
authors.initials: E
authors.lastname: Pilling
authors.forename: G
authors.initials: G
authors.lastname: Lauer
authors.forename: M
authors.initials: M
authors.lastname: Gelinsky
authors.forename: U
authors.initials: U
authors.lastname: Eckelt
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002130:Calcium Phosphates; D024042:Collagen Type I / Q000627:therapeutic use*; D004338:Drug Combinations; D008334:Mandible / Q000473:pathology / Q000601:surgery*; D008855:Microscopy, Electron, Scanning; D009930:Organic Chemicals; D016348:Osseointegration / Q000502:physiology; D018583:Pliability; D013552:Swine; D013556:Swine, Miniature
chemical_list: D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D024042:Collagen Type I; D004338:Drug Combinations; D009930:Organic Chemicals; C471699:biocement D