title: Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems.
abstract: The estrogenic activity of several intermediary plant compounds has raised concern about possible risks of unwanted interference with endocrine regulation, but on the other hand there are potential medical benefits, in particular in treatment of menopausal symptoms or cancer. In the present study, we compare the estrogenic effects of phytoestrogens naringenin, 8-prenylnaringenin, 6-(1,1-dimethylallyl)naringenin, and the synthetic 4'-acetyl-7-prenyloxynaringenin. Two mammalian in vitro systems and a fish in vivo system were used to study the estrogenic properties with reference to genistein, 17-beta-estradiol or ethynylestradiol. Strong differences were observed between the mammalian in vitro and the fish in vivo test system. In the medaka sex reversal/vtg gene expression assay no estrogenic effects of the naringenin-type flavonoids were observed, while mammalian in vitro systems showed a similar and graded response to the test compounds.
authors.affiliation: Institute of Zoology, Dresden University of Technology, 01062 Dresden, Germany. oliver.zierau@mailbox.tu-dresden.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Zierau
authors.forename: Juliane
authors.initials: J
authors.lastname: Hamann
authors.forename: Sandra
authors.initials: S
authors.lastname: Tischer
authors.forename: Pia
authors.initials: P
authors.lastname: Schwab
authors.forename: Peter
authors.initials: P
authors.lastname: Metz
authors.forename: Günter
authors.initials: G
authors.lastname: Vollmer
authors.forename: Herwig O
authors.initials: HO
authors.lastname: Gutzeit
authors.forename: Stefan
authors.initials: S
authors.lastname: Scholz
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000493:pharmacokinetics / Q000494:pharmacology; D044950:Flavanones / Q000493:pharmacokinetics* / Q000494:pharmacology*; D005419:Flavonoids / Q000493:pharmacokinetics / Q000494:pharmacology; D019833:Genistein / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D009990:Oryzias / Q000502:physiology*; D048789:Phytoestrogens / Q000145:classification / Q000493:pharmacokinetics* / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000378:metabolism*; D012733:Sex Differentiation / Q000187:drug effects* / Q000502:physiology; D013045:Species Specificity
chemical_list: D004967:Estrogens; D044950:Flavanones; D005419:Flavonoids; D048789:Phytoestrogens; D011960:Receptors, Estrogen; D019833:Genistein; C005273:naringenin