title: Reduction of carboxyhaemoglobin levels in the venous blood of cigarette smokers following the administration of carbogen.
abstract: Cigarette smokers have high carboxyhaemoglobin levels which can promote tumour radioresistance. Inhalation of carbogen gas shortens the half-life of carboxyhaemoglobin, increasing tumour radiosensitivity in animal models. Breathing 2.5% carbogen for 30 min results in a greater reduction in venous blood COHb levels than breathing 5% carbogen for 7 min.
authors.affiliation: Department of Radiation Oncology, Vancouver Cancer Centre, BC Cancer Agency, Vancouver, BC, Canada.
authors.forename: Graham
authors.initials: G
authors.lastname: Macdonald
authors.forename: Natalie
authors.initials: N
authors.lastname: Kondor
authors.forename: Vandad
authors.initials: V
authors.lastname: Yousefi
authors.forename: Alex
authors.initials: A
authors.lastname: Green
authors.forename: Frances
authors.initials: F
authors.lastname: Wong
authors.forename: Christina
authors.initials: C
authors.lastname: Aquino-Parsons
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002245:Carbon Dioxide / Q000008:administration & dosage* / Q000494:pharmacology*; D002263:Carboxyhemoglobin / Q000032:analysis* / Q000378:metabolism*; D015687:Cell Hypoxia; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy; D010100:Oxygen / Q000008:administration & dosage* / Q000494:pharmacology*; D011836:Radiation Tolerance; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D011878:Radiotherapy; D012907:Smoking / Q000009:adverse effects*
chemical_list: D011838:Radiation-Sensitizing Agents; D002245:Carbon Dioxide; C011700:carbogen; D002263:Carboxyhemoglobin; D010100:Oxygen