Exacerbation of protracted-relapsing experimental allergic encephalomyelitis in DA rats by gluten-free diet.
The observation of neurological dysfunctions resembling multiple sclerosis (MS) seen clinically and/or by MRI in patients with celiac disease has focused attention on the possibility that cryptic gluten sensitivity may be involved in the pathogenesis of MS. Here we study the effects of a gluten-free diet on the course of protracted-relapsing EAE in DA rats, serving as a preclinical model of human MS. The data show not only that this nutritional approach failed to ameliorate development of the disease but rather that it exacerbated the course.
Di Marco
Roberto
R
Department of Microbiological and Gynaecological Sciences, School of Medicine, University of Catania, Italy.
Mangano
Katia
K
Quattrocchi
Cinzia
C
Amato
Filiberto
F
Nicoletti
Ferdinando
F
Buschard
Karsten
K
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D004032:Diet; D004035:Diet Therapy; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D005983:Glutens; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew
D005983:Glutens