title: Anti-inflammatory, antinociceptive, and antipyretic effects of Lantana trifolia Linnaeus in experimental animals.
abstract: Lantana trifolia L. (Verbenaceae) is traditionally used as an anti-inflammatory medicinal plant in Venezuela. The methanol extract of the aerial parts of L. trifolia were assessed for the anti-inflammatory, anti-nociceptive and anti-pyretic properties. The extract produced an inhibition of carrageenan-induced edema in the rat paw over a dose range of 10-300 mg/kg i.p.; the dose-response curve was bell-shaped with a maximal effect at 100 mg/kg. The extract also produced a small but significant increase in the response latency of rats subjected to the hot plate, a thermal pain test that only detects analgesia by high-efficacy agents. The extract did not exhibit antipyretic activity. Thus, the L. trifolia extract could have therapeutically relevant anti-inflammatory and analgesic properties in humans.
authors.affiliation: Natural Products Laboratory, Faculty of Sciences, University of Zulia, Maracaibo, Venezuela.
authors.forename: Bercy
authors.initials: B
authors.lastname: Uzcátegui
authors.forename: Dinorah
authors.initials: D
authors.lastname: Avila
authors.forename: Heberto
authors.initials: H
authors.lastname: Suárez-Roca
authors.forename: Luis
authors.initials: L
authors.lastname: Quintero
authors.forename: José
authors.initials: J
authors.lastname: Ortega
authors.forename: Beatriz
authors.initials: B
authors.lastname: González
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy; D032410:Lantana; D008297:Male; D010146:Pain / Q000188:drug therapy; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D028321:Plant Preparations