title: Prescription drug use and risk of acute myeloid leukemia by French-American-British subtype: results from a Los Angeles County case-control study.
abstract: Chemotherapy is a well-established risk factor for acute myeloid leukemia (AML) but little is known about other prescription drugs and AML risk. We report data from a population-based Los Angeles County study in which 299 matched case-control pairs had complete data on prescription drug use and 88% of cases were subtyped according to the French-American-British (FAB) criteria. Cases were diagnosed between 1987 and 1994. Prescription nonsteroidal anti-inflammatory drug (NSAID) use for at least 4 weeks in the 2 to 10 years before diagnosis was associated with decreased risk (odds ratio = 0.5, 95% confidence interval=0.3, 1.0; p=0.04) with dose-response most evident for FAB subtype M2 (OR = 0.6, CI: 0.1, 2.9 for duration < or =6 months; OR = 0.2, CI: 0.0, 1.6 for >6 months). For subtype M4, ORs increased with increasing duration of benzodiazepine use in the 2 to 10 years before diagnosis (OR = 1.5, CI: 0.3, 9.0 for < or =6 months vs. OR = 5.0, CI: 0.6, 42.8 for >6 months). These results suggest that prescription drugs other than chemotherapy may have FAB subtype-specific effects on AML risk.
authors.affiliation: Keck School of Medicine, University of Southern California (USC), Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, CA, USA. jpogoda@statology.com
authors.forename: Janice M
authors.initials: JM
authors.lastname: Pogoda
authors.forename: Jonathan
authors.initials: J
authors.lastname: Katz
authors.forename: Roberta
authors.initials: R
authors.lastname: McKean-Cowdin
authors.forename: Peter W
authors.initials: PW
authors.lastname: Nichols
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Ross
authors.forename: Susan
authors.initials: S
authors.lastname: Preston-Martin
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001569:Benzodiazepines / Q000009:adverse effects; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D011307:Drug Prescriptions; D004358:Drug Therapy; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000145:classification* / Q000209:etiology*; D015141:Los Angeles; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012306:Risk; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001569:Benzodiazepines