title: [Severe imported malaria in adults: a retrospective study of 32 cases admitted to intensive care units].
abstract: BACKGROUND
  Few studies have focused on severe imported malaria in patients admitted to intensive care units. We, therefore, undertook a retrospective study in the University Hospital of Montpellier.
  
  
  METHODS
  All patients, more than 15 years-old with falciparum malaria who were admitted to intensive care units between October 1997 and April 2004 were included. Main epidemiological features, criteria of admission, treatment and outcome were investigated.
  
  
  RESULTS
  Thirty-two patients were included, representing 9% of falciparum malaria cases diagnosed in the same period. The mean age was 44 years. All patients acquired falciparum malaria in sub-Sahara Africa and 25 patients were nonimmune. Chemoprophylaxis was absent or inadequate in 94%. The mean time from symptom onset and treatment initiation was 6 days. Mean parasitemia on admission was 15%. Criteria of admission were impaired consciousness in 69%, acute renal failure in 19% and isolated high parasitemia in 19% of the cases. All, but one received quinine therapy and a loading dose was performed in 34%. Seven patients (22%) had community-acquired coinfections and six (19%) had nosocomial infections. Mortality was 16%. Causes of death were refractory shock, cerebral edema, and acute respiratory distress syndrome.
  
  
  CONCLUSIONS
  Severe imported malaria remains associated with a bad outcome. Improving chemoprophylaxis and an earlier diagnosis may reduce significantly this mortality.
authors.affiliation: Service de réanimation médicale assistance respiratoire, hôpital Gui de Chauliac, 80, avenue Augustin-Fliche, 34295 Montpellier, France. p-corne@chu-montpellier.fr
authors.forename: P
authors.initials: P
authors.lastname: Corne
authors.forename: K
authors.initials: K
authors.lastname: Klouche
authors.forename: D
authors.initials: D
authors.lastname: Basset
authors.forename: L
authors.initials: L
authors.lastname: Amigues
authors.forename: J-J
authors.initials: JJ
authors.lastname: Béraud
authors.forename: O
authors.initials: O
authors.lastname: Jonquet
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use; D005602:France; D006801:Humans; D007362:Intensive Care Units; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality / Q000635:transmission; D012189:Retrospective Studies; D016019:Survival Analysis; D014195:Travel; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials