title: Nutrient induced thermogenesis during major colorectal excision--a pilot study.
abstract: OBJECTIVE
  Hypothermia may occur during general anaesthesia and is associated with postoperative coagulopathy, ischaemic cardiac events, wound infections and increased metabolic expenditure due to shivering. The purpose of the present pilot study was to determine whether the administration of certain amino acids (Vamin 18) during general anaesthesia could prevent postoperative hypothermia.
  
  
  METHODS
  Two groups of patients were studied. The study group comprised 10 patients who underwent complex major colorectal operations. In this group an infusion of 500 mls of Vamin 18 (Fresenius Kabi Ltd) was commenced immediately after induction of anaesthesia but prior to the skin incision. In a control group (n=10) who underwent similar surgical procedures Vamin 18 was not administered. In both groups core body temperature, using an oesophageal probe was recorded during the procedure and recovery period. Ambient theatre and recovery room temperature and other body warming techniques were standardized for all patients. Statistical analysis was performed using t-test for comparison of linear temperature changes at different times during the procedure for both groups of patients.
  
  
  RESULTS
  The body temperature was statistically significantly reduced in both groups at skin incision when compared with temperature prior to induction of anaesthesia. (
  
  
  METHODS
  mean 0.74 degrees C, SD=0.38, P =<0.001;
  
  
  METHODS
  mean 0.54 degrees C, SD=0.43, P=0.003]. The increase in body temperature between the time of skin incision and recovery period was statistically significant (P=0.012) in the study group but not so in the control group (P=0.730).
  
  
  CONCLUSIONS
  The results of the present pilot study demonstrate that complex colorectal operations are associated with a decrease in body temperature which is most marked immediately after the induction of anaesthesia. The perioperative administration of Vamin 18 appears to increase the rate of recovery of body temperature. The impact of this thermogenic effect on perioperative morbidity and mortality should be studied in a prospective randomised clinical trial.
authors.affiliation: Department of Colorectal Surgery, Singleton Hospital, Sketty, Swansea, UK.
authors.forename: T V
authors.initials: TV
authors.lastname: Chandrasekaran
authors.forename: R N W
authors.initials: RN
authors.lastname: Morgan
authors.forename: R A
authors.initials: RA
authors.lastname: Mason
authors.forename: P S
authors.initials: PS
authors.lastname: Mangat
authors.forename: A J
authors.initials: AJ
authors.lastname: Watkins
authors.forename: N D
authors.initials: ND
authors.lastname: Carr
mesh_terms: D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage*; D003110:Colonic Neoplasms / Q000601:surgery; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D004573:Electrolytes; D005260:Female; D005947:Glucose; D006801:Humans; D007035:Hypothermia / Q000209:etiology* / Q000517:prevention & control*; D015212:Inflammatory Bowel Diseases / Q000601:surgery; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D057947:Parenteral Nutrition Solutions; D019990:Perioperative Care; D010865:Pilot Projects; D012004:Rectal Neoplasms / Q000601:surgery; D012996:Solutions; D022722:Thermogenesis / Q000187:drug effects*
chemical_list: D000596:Amino Acids; D004573:Electrolytes; D057947:Parenteral Nutrition Solutions; D012996:Solutions; C545824:amino-acid, glucose, and electrolyte solution; D005947:Glucose