title: Cue-provoked craving and nicotine replacement therapy in smoking cessation.
abstract: Cue exposure paradigms have been used to examine reactivity to smoking cues. However, it is not known whether cue-provoked craving is associated with smoking cessation outcomes or whether cue reactivity can be attenuated by nicotine replacement therapy (NRT) in clinical samples. Cue-provoked craving ratings and reaction time responses were measured on the 1st day of abstinence among 158 smokers who had been randomized to high-dose nicotine (35 mg) or placebo patch. The nicotine patch reduced overall levels of craving but did not attenuate cue-provoked craving increases or reaction time responses. Cue-provoked craving predicted relapse among participants on the nicotine patch but not among those on placebo. In summary, NRT users could benefit from treatment that attenuates cue-provoked craving.
authors.affiliation: Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA. ajwaters@mdanderson.org
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Waters
authors.forename: Saul
authors.initials: S
authors.lastname: Shiffman
authors.forename: Michael A
authors.initials: MA
authors.lastname: Sayette
authors.forename: Jean A
authors.initials: JA
authors.lastname: Paty
authors.forename: Chad J
authors.initials: CJ
authors.lastname: Gwaltney
authors.forename: Mark H
authors.initials: MH
authors.lastname: Balabanis
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D003463:Cues; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000627:therapeutic use*; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation / Q000379:methods*
chemical_list: D009538:Nicotine