[Prevalence of hepatitis B virus genotypes and the occurrence of precore mutation A-1896 and to correlate them with the clinical presentation of chronic hepatitis, in a population group of the Eastern Amazon region].
Hepatitis B virus (HBV) infection presents itself with a variety of clinical manifestations. The present work aims to describe the prevalence of HBV genotypes and the occurrence of precore mutation A-1896 in a population group of the Eastern Amazon region of Brazil and to correlate them with the clinical presentation of chronic HBV infection. 51 HBsAg carriers (HBV-DNA positive) were selected and divided into three groups: A (14 asymptomatic subjects), B (20 HBeAg positive symptomatic patients) and C (17 HBeAg negative symptomatic patients). Using an automa ed DNA sequencer ABI model 377 by sequencing for determined of genotypes and precore mutation. The results showed that the genotype A was the most commonly found (81.1%, 89.5% and 93.7% in groups A, B and C, respectively) and precore mutation A-1896 was described in 11.5% (3/26) of group A subjects. Genotype A of HBV was the most prevalent (89.1%) and low occurrence of precore mutation A-1896, both not associate with the worst outcome of the chronic infection of HBV.
Conde
Simone Regina Souza da Silva
SR
Fundação Santa Casa de Misericórdia do Pará, Belém, PA. conde@libnet.com.br
Móia
Lizomar de Jesus Pereira
Lde J
Barbosa
Maria Silvia Brito
MS
Amaral
Ivanete do Socorro Abarcado
Ido S
Miranda
Esther Castello Branco de Mello
EC
Soares
Manoel do Carmo Pereira
Mdo C
Brito
Elizabete Maria de Figueiredo
EM
Souza
Olglaíze do Socorro Costa
Odo S
de Araújo
Marialva Tereza
MT
Demachki
Sâmia
S
Rebello
João Renato Pinho
JR
Mesquita
Michele Gomes Soares
MG
Denis
Alberto Bertollini
AB
Ishak
Ricardo
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005838:Genotype; D006512:Hepatitis B Core Antigens / Q000097:blood* / Q000235:genetics; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D015995:Prevalence; D019562:Viral Load
D004279:DNA, Viral; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens