Intravascular ultrasonic comparative analysis of degree of intimal hyperplasia produced by four different stents in the coronary arteries.
Intravascular ultrasound studies were performed at angiographic follow-up on 121 native coronary lesions treated with 1 bare metal stent (n = 50), high-dose dexamethasone-eluting stents (n = 18), non-polymer-based paclitaxel-eluting stents (n = 18), or sirolimus-eluting stents (n = 35). Paclitaxel- and sirolimus-eluting stents reduced mean intimal hyperplasia thickness compared with bare metal stents by 49% and 90% (p = 0.048 and p <0.001), respectively, whereas mean intimal hyperplasia thickness treated with dexamethasone-eluting stents was similar to those lesions treated with bare metal stents.
Hoffmann
Rainer
R
Medical Clinic I, University RWTH Aachen, Aachen, Germany. RHoffmann@UKAACHEN.de
Radke
Peter W
PW
Ortlepp
Jan R
JR
Haager
Philipp K
PK
Blindt
Rüdiger
R
Iofina
Ekatarina
E
Franke
Andreas
A
Langenberg
Roswitha
R
Weber
Christian
C
Hanrath
Peter
P
D023903:Coronary Restenosis / Q000209:etiology; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology*; D003907:Dexamethasone; D006801:Humans; D006965:Hyperplasia; D017239:Paclitaxel; D011474:Prosthesis Design; D020123:Sirolimus; D015607:Stents / Q000009:adverse effects; D017539:Tunica Intima / Q000473:pathology; D018084:Ultrasonography, Interventional
D003907:Dexamethasone; D017239:Paclitaxel; D020123:Sirolimus