[Clinical analysis of nosocomial pulmonary fungal infection in patients with cancer].
OBJECTIVE
Nosocomial fungal infection is an important complication of cancer patients. Among them, pulmonary fungal infection is over 20%. This study was designed to analyze and evaluate risk factors, and clinical features of nosocomial pulmonary fungal infection in patients with cancer.


METHODS
In 1 229 patients with malignant tumor, clinical records of 78 patients with nosocomial pulmonary fungal infection were retrospectively analyzed.


RESULTS
Pulmonary fungal infection rate was 6.35% (78/1 229). The major fungus was Candida albicans (68.18%). The main risk factors were age of > or =50 years (P< 0.005), primary site (lung cancer, P< 0.001), cancer stage (stage IV, P< 0.005), pulmonary radiotherapy (P< 0.001), chemotherapy (P< 0.001), and long-term hospitalization ( >2 weeks, P< 0.005).


CONCLUSIONS
The effective methods to reduce nosocomial pulmonary fungal infection in patients with cancer are reducing risk factors, early diagnosis, and timely treatment.
Jiang
Yu
Y
Key Laboratory of Biotherapy of Human Diseases, Ministry of Education, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Li
Jun-Ying
JY
Li
Mei
M
Zhou
Lin
L
Peng
Feng
F
Wei
Yu-Quan
YQ
D000328:Adult; D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002176:Candida albicans / Q000302:isolation & purification*; D041022:Candida tropicalis / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology; D003428:Cross Infection / Q000209:etiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008172:Lung Diseases, Fungal / Q000209:etiology* / Q000382:microbiology; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012307:Risk Factors; D012621:Seasons
D000970:Antineoplastic Agents