title: Metastatic glioblastoma in cervical lymph node after repeated craniotomies: report of a case with diagnosis by fine needle aspiration.
abstract: Head and neck metastasis from glioblastoma is rare event usually seen in patients with previous and repeated surgery. We present the case of a 35 yr-old-female suffering from metastatic glioblastoma in cervical lymph node that was diagnosed by fine needle aspiration. During the last 4 yr, she had four separate craniotomies for the recurrent brain tumors. Cytological diagnosis was made by light microscopy with immunostaining with glial fibrillay acid protein. Chemotherapy with vincristine and procarbazine was performed. The cervical masses were decreased in size and some disappeared while the intracranial glioblastoma continued to grow during chemotherapy. We discuss possible explanations for these different courses after chemotherapy in extraneural metastatic glioblastoma and primary intracranial glioblastoma.
authors.affiliation: Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hospital & Medical School, Gwangju, Korea.
authors.forename: Kyung-Sub
authors.initials: KS
authors.lastname: Moon
authors.forename: Shin
authors.initials: S
authors.lastname: Jung
authors.forename: Min-Cheol
authors.initials: MC
authors.lastname: Lee
authors.forename: In-Young
authors.initials: IY
authors.lastname: Kim
authors.forename: Hyun-Woo
authors.initials: HW
authors.lastname: Kim
authors.forename: Jung-Kil
authors.initials: JK
authors.lastname: Lee
authors.forename: Tae-Sun
authors.initials: TS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000601:surgery*; D003399:Craniotomy; D005260:Female; D005909:Glioblastoma / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D009333:Neck; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents