title: Tissue inhibitor of metalloproteinase 1 regulates resistance to infection.
abstract: Tissue inhibitor of metalloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Marie Mei
authors.initials: MM
authors.lastname: Lee
authors.forename: Bong-June
authors.initials: BJ
authors.lastname: Yoon
authors.forename: Keith
authors.initials: K
authors.lastname: Osiewicz
authors.forename: Michael
authors.initials: M
authors.lastname: Preston
authors.forename: Brian
authors.initials: B
authors.lastname: Bundy
authors.forename: Anna M
authors.initials: AM
authors.lastname: van Heeckeren
authors.forename: Zena
authors.initials: Z
authors.lastname: Werb
authors.forename: Paul D
authors.initials: PD
authors.lastname: Soloway
mesh_terms: D000818:Animals; D008171:Lung Diseases / Q000276:immunology; D019278:Matrix Metalloproteinase 3 / Q000502:physiology; D020780:Matrix Metalloproteinase 9 / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D011552:Pseudomonas Infections / Q000276:immunology*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000502:physiology*
chemical_list: D019715:Tissue Inhibitor of Metalloproteinase-1; D019278:Matrix Metalloproteinase 3; D020780:Matrix Metalloproteinase 9