title: Free radical theory of apoptosis and metamorphosis.
abstract: Reactive oxygen species (ROS) are the major factors that induce oxidative modification of DNA and gene mutation. ROS can elicit oxidative stress and affect a wide variety of physiological and pathological processes including embryonal development, maturation and aging.
authors.affiliation: Department of Biochemistry & Molecular Pathology, Osaka City University Medical School, Osaka, Japan. inoue@med.osaka-cu.ac.jp
authors.forename: Masayasu
authors.initials: M
authors.lastname: Inoue
authors.forename: Eisuke F
authors.initials: EF
authors.lastname: Sato
authors.forename: Manabu
authors.initials: M
authors.lastname: Nishikawa
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hiramoto
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kashiwagi
authors.forename: Kozo
authors.initials: K
authors.lastname: Utsumi
mesh_terms: D000818:Animals; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism; D002331:Carnitine / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D002470:Cell Survival; D016572:Cyclosporine / Q000494:pharmacology; D004247:DNA / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005609:Free Radicals; D006801:Humans; D008675:Metamorphosis, Biological; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D011898:Ranidae; D017382:Reactive Oxygen Species; D013997:Time Factors; D014508:Urea / Q000378:metabolism / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D005609:Free Radicals; D017382:Reactive Oxygen Species; D016572:Cyclosporine; D014508:Urea; D004247:DNA; D002374:Catalase; D002331:Carnitine; D010100:Oxygen; D002118:Calcium