title: Direct pericardial involvement of non-small cell lung cancer rapidly developing pericardial constriction.
abstract: A 71-year-old male, who had been followed up after being treated with chemo-radiotherapy for non-small cell lung cancer (adenocarcinoma), rapidly developed dyspnea and mild fever. Radiographs showed left pleural effusion and cardiomegaly, and echocardiographic examination revealed echo-free space, suggesting a pericardial effusion. The patient was treated conservatively without any surgical procedures such as pericardiocentesis. Disappearance of the echo-free space was followed by development of pericardial constriction within two months. At post-mortem examination, a direct extension to the pericardium from the primary lesion of the right upper lobe through the mediastinum was observed. The rapid development of pericardial constriction is extremely rare in patients with malignant pericarditis.
authors.affiliation: The First Department of Medicine, Shinshu University School of Medicine, Asahi, Matsumoto 390-8621, Japan.
authors.forename: Toshihide
authors.initials: T
authors.lastname: Wakamatsu
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Urushihata
authors.forename: Keisaku
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Shiniichirou
authors.initials: S
authors.lastname: Uchikawa
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
authors.forename: Ayahiko
authors.initials: A
authors.lastname: Iwamura
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yazawa
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004452:Echocardiography; D006333:Heart Failure / Q000209:etiology; D006338:Heart Neoplasms / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D010490:Pericardial Effusion / Q000000981:diagnostic imaging / Q000209:etiology*; D010496:Pericardium / Q000473:pathology*