Neurobehavioral effects of treatment for opiate withdrawal.
A partially randomised, controlled trial was performed to test the hypothesis that opiate exposed infants treated with diluted tincture of opium (DTO) and phenobarbital would have better neurobehavioral scores than infants treated with DTO alone. Compared with those treated with DTO alone (n = 15), infants treated with DTO and phenobarbital (n = 17) were more interactive, had smoother movements, were easier to handle, and less stressed. Dual treatment results in improved neurobehavioral organisation during the first three weeks of life, which may indicate a more rapid recovery from opiate withdrawal.
Coyle
M G
MG
Department of Pediatrics, Brown Medical School, Women & Infants Hospital, 101 Dudley Street, Providence, Rhode Island 02905-2401, USA. coylem@southcoast.org
Ferguson
A
A
Lagasse
L
L
Liu
J
J
Lester
B
B
D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D003932:Heroin / Q000009:adverse effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D018730:Infant Behavior / Q000187:drug effects; D007231:Infant, Newborn; D008691:Methadone / Q000009:adverse effects*; D009357:Neonatal Abstinence Syndrome / Q000188:drug therapy*; D009892:Opium / Q000627:therapeutic use*; D010634:Phenobarbital / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects; D016896:Treatment Outcome
D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives; D003932:Heroin; D009892:Opium; D008691:Methadone; D010634:Phenobarbital