title: Phase II study of E7070 in patients with metastatic melanoma.
abstract: E7070 is a synthetic chloro-indolyl sulphonamide that is being developed as an anti cancer agent. In this phase II study, 28 patients with metastatic melanoma received 700 mg/m(2) of E7070 as a 60-min infusion repeated every 3 weeks. Although therapy was well tolerated, with one patient receiving 14 courses of treatment, there were only minor responses on independent radiological review. E7070 does not warrant further development as a single agent for the treatment of metastatic melanoma.
authors.affiliation: University of Edinburgh, Cancer Research Centre, Western General Hospital, Edinburgh, UK. john.smyth@cancer.org.uk
authors.forename: J F
authors.initials: JF
authors.lastname: Smyth
authors.forename: S
authors.initials: S
authors.lastname: Aamdal
authors.forename: A
authors.initials: A
authors.lastname: Awada
authors.forename: C
authors.initials: C
authors.lastname: Dittrich
authors.forename: F
authors.initials: F
authors.lastname: Caponigro
authors.forename: P
authors.initials: P
authors.lastname: Schöffski
authors.forename: M
authors.initials: M
authors.lastname: Gore
authors.forename: T
authors.initials: T
authors.lastname: Lesimple
authors.forename: N
authors.initials: N
authors.lastname: Djurasinovic
authors.forename: B
authors.initials: B
authors.lastname: Baron
authors.forename: M
authors.initials: M
authors.lastname: Ravic
authors.forename: P
authors.initials: P
authors.lastname: Fumoleau
authors.forename: C J A
authors.initials: CJ
authors.lastname: Punt
mesh_terms: D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: C439829:N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide; D013449:Sulfonamides