title: Predictors of disease-related concerns and other aspects of health-related quality of life in outpatients with inflammatory bowel disease.
abstract: OBJECTIVE
  Disease-related concerns are a major dimension of health-related quality of life in inflammatory bowel disease (IBD). The aim of this study was to assess the concerns of IBD patients in an outpatient sample, and to determine the impact of psychological and disease factors on concerns and on other variables of health-related quality of life.
  
  
  METHODS
  Seventy-two outpatients with IBD were assessed with regard to disease-related concerns [with the Rating Form of IBD Patients' Concerns (RFIPC)], psychological symptoms and somatic complaints non-specific to IBD as dependent variables. Coping with illness, health locus of control, and disease variables were assessed as predictor variables. Multiple regression analyses determined the independent contribution of each predictor on the dependent variables.
  
  
  RESULTS
  Women reported more intense concerns than men. No difference in concerns was found between patients with Crohn's disease and ulcerative colitis. The highest predictive value for the RFIPC total score was found for depressive coping. It explained a greater proportion of variance on the RFIPC total score (23%) than demographic (10%) and disease variables (7%), and comparably impinged on RFIPC subscores. Furthermore, depressive coping was significantly associated with psychological distress, the self-rated health status and somatic complaints non-specific to IBD.
  
  
  CONCLUSIONS
  Our findings suggest that in IBD psychological variables, particularly depressive coping, are more predictive than medical variables for disease-related concerns and other variables of health-related quality of life. Further studies are needed to examine the effects that the way of coping with disease have on long-term outcome in IBD.
authors.affiliation: Department of Medicine II (Gastroenterology/Hepatology/Infectious Diseases), University of Heidelberg, Medical Faculty of Mannheim, Mannheim, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Mussell
authors.forename: Ulrich
authors.initials: U
authors.lastname: Böcker
authors.forename: Nils
authors.initials: N
authors.lastname: Nagel
authors.forename: Manfred V
authors.initials: MV
authors.lastname: Singer
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D003093:Colitis, Ulcerative / Q000523:psychology / Q000534:rehabilitation; D003424:Crohn Disease / Q000523:psychology / Q000534:rehabilitation; D003863:Depression / Q000523:psychology; D005260:Female; D006304:Health Status; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000523:psychology* / Q000534:rehabilitation; D007389:Internal-External Control; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D011788:Quality of Life; D012044:Regression Analysis; D012737:Sex Factors; D013315:Stress, Psychological / Q000523:psychology