The effects of the immature rat model of febrile seizures on the occurrence of later generalized tonic-clonic and absence epilepsy.
This study was designed to investigate whether the intensity of experimental febrile seizures reduces the threshold to generalized tonic-clonic epilepsy and its effects on the development of generalized absence epilepsy in adulthood. For the evaluation of absence epilepsy, WAG/Rij rats and for the tonic-clonic seizures, PTZ injected Wistar rats were used. Our results showed that while the frequency of the experimental febrile seizures facilitates PTZ-induced generalized tonic-clonic seizures, it does not influence the properties of absence epileptic seizures in adulthood.
Ateş
Nurbay
N
Department of Physiology, Faculty of Medicine, Kocaeli University, 41900, Derince, Kocaeli, Turkey. nates@kou.edu.tr
Akman
Ozlem
O
Karson
Ayşe
A
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development / Q000503:physiopathology*; D015984:Causality; D003292:Convulsants; D004195:Disease Models, Animal; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology* / Q000503:physiopathology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D003294:Seizures, Febrile / Q000150:complications* / Q000503:physiopathology*
D003292:Convulsants; D010433:Pentylenetetrazole