[Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat].
OBJECTIVE
To study the protective effect of Ligustrazine on IR after local cerebral ischemia of rat.


METHODS
Models of rat IR after local cerebral ischemia were prepared by electrocagulation of the middle cerebral artery, and changes of serum insulin, tomer necrosis factor-alpha (TNF-alpha), plasma endothelin-1 (ET-1), nitric oxide (NO) and nitric oxide synthase (NOS) were observed 2 weeks after the ischemia.


RESULTS
Ligustrazine could significantly reduce serum insulin (P < 0.01), the content of plasma ET-1 (P < 0.01) and serum TNF-alpha (P < 0.01), the activity of brain tissue NO and NOS (P < 0.01). The drug also increased insulin sensitivity indexes (ISI).


CONCLUSIONS
The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-alpha content in serum, NO content and NOS activities in tissue.
Wang
Yuan-jing
YJ
Department of Combination of Chinese and Western Medicine, Anhui College of Traditional Chinese Medicine, Hefei 230038, Anhui, China.
Jiang
An-hong
AH
Wang
Qin-mao
QM
Bai
Mei
M
Ma
Ke-long
KL
D000818:Animals; D002545:Brain Ischemia / Q000097:blood* / Q000209:etiology; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology; D011719:Pyrazines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D019332:Endothelin-1; D007328:Insulin; D018696:Neuroprotective Agents; D011719:Pyrazines; D014409:Tumor Necrosis Factor-alpha; D013482:Superoxide Dismutase; C017953:tetramethylpyrazine