title: [Diagnosis and therapy of pneumocystosis complicated after renal transplantation].
abstract: OBJECTIVE
  To investigate the early diagnosis, treatment and prevention of pneumocystosis complicated after renal transplantation.
  
  
  METHODS
  Data from 12 cases of kidney transplant recipients who developed pneumocystosis were analyzed by clinical symptoms and signs, results of laboratory examination, imaging, bronchoscopy and biopsy. Combined TMP/SMZ was used for the prevention and treatment.
  
  
  RESULTS
  Pneumocystis carinii (Pc) detection rate was 16.7% from alveolar douche, 66.7% with bronchoscopy and biopsy. Two cases was diagnosed by PCR method with sputum. Plain chest film showed 58.3% of lung cirrhosis. CT showed 50% frosted glass-like change in lungs and 25% with lung consolidation. Eleven cases were cured but one died.
  
  
  CONCLUSIONS
  Pc detection by bronchoscopy and biopsy, and PCR are most helpful in the diagnosis of pneumocystosis complicated with renal transplantation, in addition to plain chest film and CT scaning. Combined TMP/SMZ is effective in the prevention and treatment of pneumocystosis.
authors.affiliation: Department of Urology, Westchina Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Sun
authors.forename: Yu-ru
authors.initials: YR
authors.lastname: Yang
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Lu
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Ke-shi
authors.initials: KS
authors.lastname: Tang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.forename: Hong
authors.initials: H
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D005260:Female; D005921:Glomerulonephritis / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy*; D011183:Postoperative Complications / Q000175:diagnosis / Q000628:therapy*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D007166:Immunosuppressive Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination