Dendritic cell-mediated T cell polarization.
Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4(+) T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T cells are controlled by regulatory T cells. The optimal balance in the development of the different types of effector and regulatory Th cells is orchestrated by dendritic cells (DC). This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response.
de Jong
Esther C
EC
Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ, Amsterdam, The Netherlands. E.C.deJong@amc.uva.nl
Smits
Hermelijn H
HH
Kapsenberg
Martien L
ML
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D018122:B7-1 Antigen / Q000276:immunology; D051940:B7-2 Antigen; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology*; D006801:Humans; D007370:Interferon Type I / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D018664:Interleukin-12 / Q000276:immunology; D020382:Interleukin-18 / Q000276:immunology; D015847:Interleukin-4 / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology; D018448:Models, Immunological; D053278:OX40 Ligand; D015398:Signal Transduction; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497964:CD86 protein, human; D007370:Interferon Type I; D020382:Interleukin-18; D008562:Membrane Glycoproteins; D053278:OX40 Ligand; C089251:TNFSF4 protein, human; D016753:Interleukin-10; D018664:Interleukin-12; D015847:Interleukin-4