Age-related loss of skeletal muscle function; impairment of gene expression.
Mechano Growth Factor (MGF) is derived from the insulin-like growth factor (IGF-I) but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. It is expressed as a pulse following muscle damage and involved in the activation of muscle satellite (stem) cells. These donate nuclei to the muscle fibers that are required for repair and for the hypertrophy processes which may have similar regulatory mechanisms. Muscles in the elderly are unable to upregulate MGF in response to exercise. This is also true in certain diseases and this helps to explain muscle loss in those conditions. There is evidence that MGF is a local tissue repair factor as well as a growth factor and that it has an important role in damage limitation and inducing repair in other post-mitotic tissues. As there is no cell replacement in these tissues there has to be an effective local cellular repair mechanism. With advancing years this seems to become deficient and there is an increased chance that the damaged cells will undergo cell death leading to progressive loss of tissue function.
Goldspink
G
G
Division of Surgery and Reconstructive Medicine, Royal Free and University College Medical School, Royal Free Campus, London, UK. goldspink@rfc.ucl.ac.uk
D000368:Aged; D000375:Aging / Q000502:physiology*; D000818:Animals; D015870:Gene Expression; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology*; D009140:Musculoskeletal Diseases / Q000503:physiopathology*