title: Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in Candida albicans-infected human gingival epithelial cells.
abstract: Increased induction of interleukin 8 (IL-8) and intercellular adhesion molecule 1 (ICAM-1) by oral epithelial cells may play a role in the host defense mechanism in oropharyngeal candidiasis; however, little is known about the expression feature of these molecules on human gingival epithelial cells (HGECs) during Candida albicans infection. In this report we present evidence that neutralization with antibody against ICAM-1 inhibited both the adherence of C. albicans to HGECs and the Candida-induced production of IL-8, suggesting a role for ICAM-1 in recognition and signaling in HGECs to express IL-8 upon infection with C. albicans.
authors.affiliation: Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita City, Osaka 565-0871, Japan. egu@dent.osaka-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Egusa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nikawa
authors.forename: Seicho
authors.initials: S
authors.lastname: Makihira
authors.forename: Anahid
authors.initials: A
authors.lastname: Jewett
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yatani
authors.forename: Taizo
authors.initials: T
authors.lastname: Hamada
mesh_terms: D002176:Candida albicans / Q000276:immunology*; D004847:Epithelial Cells / Q000382:microbiology; D005786:Gene Expression Regulation; D005881:Gingiva / Q000382:microbiology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000502:physiology*; D016209:Interleukin-8 / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D016209:Interleukin-8; D012333:RNA, Messenger; D018799:Intercellular Adhesion Molecule-1