Viral modulation of NK cell immunity.
Natural killer (NK) cells have been implicated in innate immune responses against viruses such as herpesviruses, which cause persistent infections in the host. In response to the selective pressure that is exerted by NK cells, many viruses have evolved strategies either to evade detection by NK cells or to modulate the activity of NK cells. Here, we review the unique relationship that exists between NK cells and viruses, with a focus on herpesviruses.
Lodoen
Melissa B
MB
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, HSE 1001G, Box 0414, San Francisco, California 94143-0414, USA.
Lanier
Lewis L
LL
D000818:Animals; D015536:Down-Regulation; D006564:Herpesviridae / Q000276:immunology* / Q000378:metabolism; D006566:Herpesviridae Infections / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008024:Ligands; D008213:Lymphocyte Activation; D018716:Molecular Mimicry; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism; D055607:Receptors, Natural Killer Cell; D011991:Receptors, Virus / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology / Q000378:metabolism
D015395:Histocompatibility Antigens Class I; D008024:Ligands; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell; D011991:Receptors, Virus; D014764:Viral Proteins