title: Biphasic sarcomatoid basal cell carcinoma (carcinosarcoma): four cases with immunohistochemistry and review of the literature.
abstract: BACKGROUND
  Biphasic sarcomatoid carcinoma (BSC), or carcinosarcoma, is an uncommon biphasic neoplasm that has been reported in diverse anatomical sites. The tumor is composed of a malignant epithelial component intimately associated with a malignant mesenchymal component, which may be homologous or heterologous. Twenty-three cases of primary cutaneous BSC have been reported in the English literature. In only eight of these cases was basal cell carcinoma the epithelial component.
  
  
  METHODS
  We report a further four cases of primary cutaneous biphasic basal cell carcinoma, and include the clinical, histological and immunohistochemical features.
  
  
  RESULTS
  The four cases showed basal cell carcinoma associated with a pleomorphic sarcomatous stroma. In addition, myofibroblastic differentiation and foci of osteoid were present in one case, and leiomyosarcomatous areas in another. The epithelial components were positive for several epithelial markers. The mesenchymal components were positive for vimentin and CD99, and negative for epithelial markers. p53 was positive with equal intensity in both epithelial and mesenchymal components. A significantly worse outcome was observed in patients with tumors measuring 40 mm or more at excision.
  
  
  CONCLUSIONS
  The sarcomatous component of the tumor is best regarded as a metaplastic transformation of the carcinomatous component. These tumors are potentially aggressive if incompletely excised, and complete resection is recommended.
authors.affiliation: Department of Pathology, Diagnostic-Medlab, Auckland, New Zealand. SBigby@dml.co.nz
authors.forename: S M
authors.initials: SM
authors.lastname: Bigby
authors.forename: A
authors.initials: A
authors.lastname: Charlton
authors.forename: M V
authors.initials: MV
authors.lastname: Miller
authors.forename: L J
authors.initials: LJ
authors.lastname: Zwi
authors.forename: G F
authors.initials: GF
authors.lastname: Oliver
mesh_terms: D000071443:12E7 Antigen; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism; D002296:Carcinosarcoma / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D015815:Cell Adhesion Molecules / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D016159:Tumor Suppressor Protein p53; D014746:Vimentin