Subfulminant liver failure associated with quetiapine.
We report the clinical history of a patient with drug induced liver injury due to quetiapine who ultimately developed subfulminant hepatic failure and died. The clinical presentation, laboratory data, as well as liver histopathology were supportive of the putative diagnosis of drug induced liver injury. To our knowledge, this is the first report of the important association between quetiapine and drug induced liver injury.
El Hajj
Ihab
I
Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Sharara
Ala I
AI
Rockey
Don C
DC
D014150:Antipsychotic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy; D003987:Dibenzothiazepines / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged; D000069348:Quetiapine Fumarate
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate