Unified perspective on proteins: a physics approach.
We study a physical system which, while devoid of the complexity one usually associates with proteins, nevertheless displays a remarkable array of proteinlike properties. The constructive hypothesis that this striking resemblance is not accidental not only leads to a unified framework for understanding protein folding, amyloid formation, and protein interactions but also has implications for natural selection.
Banavar
Jayanth R
JR
Department of Physics, 104 Davey Lab, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Hoang
Trinh X
TX
Maritan
Amos
A
Seno
Flavio
F
Trovato
Antonio
A
D001665:Binding Sites; D003198:Computer Simulation; D008956:Models, Chemical; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000032:analysis / Q000737:chemistry*; D010825:Physics / Q000379:methods; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000032:analysis / Q000737:chemistry*
D046912:Multiprotein Complexes; D011506:Proteins