title: Population-based incidence rates of malignant melanoma of the vulva in Germany.
abstract: OBJECTIVE
  Only few population-based incidence analyses of vulvar melanoma including the United States and Sweden are currently available. We studied the incidence of vulvar melanoma in a large population-based cancer registry of East Germany and compared our findings with the United States and Sweden.
  
  
  METHODS
  We extracted vulvar melanoma registered between 1976 and 1989 in the former National Cancer Registry of the German Democratic Republic (GDR) and of three new East German cancer registries of the federal states of Sachsen, Brandenburg, and Mecklenburg-Vorpommern of the period 1998 to 2002. We calculated age-specific and age-standardized incidence rates using the World Standard Population.
  
  
  RESULTS
  One hundred two cases (1976-1989, former GDR) and twenty-five cases of vulvar melanoma (1998-2002, three new federal states) were registered. The age-standardized incidence rate (World Standard Population) remained constant over the period from 1976 to 1989 and ranged between 0.26 and 0.52 cases per million. From 1998 to 2002, the incidence rate was 0.48 per million. The ratio of registered vulvar melanoma to skin melanoma was 1:71, and the ratio of vaginal melanoma to skin melanoma was 1:314. Age at diagnosis during the period 1976 to 1989 was lower among women with vulvar melanoma (median age 70 years) compared to women with vulvar tumors other than melanoma (median age 73 years).
  
  
  CONCLUSIONS
  The risk of vulvar melanoma was considerably lower in East Germany than in the United States and Sweden. Due to the rarity of vulvar melanoma, population-based cancer registries are hampered to study this tumor in detail.
authors.affiliation: Institute of Medical Epidemiology, Biometry and Epidemiology, University Hospital of Halle, 06097 Halle (Saale), Germany. andreas.stang@medizin.uni-halle.de
authors.forename: A
authors.initials: A
authors.lastname: Stang
authors.forename: B
authors.initials: B
authors.lastname: Streller
authors.forename: B
authors.initials: B
authors.lastname: Eisinger
authors.forename: K H
authors.initials: KH
authors.lastname: Jöckel
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008545:Melanoma / Q000453:epidemiology* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D012042:Registries; D012878:Skin Neoplasms / Q000453:epidemiology / Q000473:pathology; D014846:Vulvar Neoplasms / Q000453:epidemiology* / Q000473:pathology