title: [Restriction analysis of N-acetyltransferase 2 gene in Caucasian population of West Siberia].
abstract: Restriction analysis of the NAT2 gene was carried out in inhabitants of Novosibirsk. Polymorphism of this gene for nine known point mutations was studied in a sample of Novosibirsk residents consisting of 109 healthy Caucasians. The frequencies of these mutations did not significantly differ from the frequencies reported for Caucasian populations of other countries. In 79 patients with lung cancer, a region of the NAT2 gene that includes 29.7% of the coding sequence was analyzed for the new mutations by the RFLP analysis. No new mutations were found in this group.
authors.forename: M V
authors.initials: MV
authors.lastname: Nikishina
authors.forename: S I
authors.initials: SI
authors.lastname: Makarova
authors.forename: A G
authors.initials: AG
authors.lastname: Akishev
authors.forename: V A
authors.initials: VA
authors.lastname: Vavilin
authors.forename: S Kh
authors.initials: SKh
authors.lastname: Degtiarev
authors.forename: V V
authors.initials: VV
authors.lastname: Liakhovich
mesh_terms: D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D006801:Humans; D017354:Point Mutation; D012150:Polymorphism, Restriction Fragment Length; D012800:Siberia; D044465:White People / Q000235:genetics*
chemical_list: D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human