title: Exacerbation of protracted-relapsing experimental allergic encephalomyelitis in DA rats by gluten-free diet.
abstract: The observation of neurological dysfunctions resembling multiple sclerosis (MS) seen clinically and/or by MRI in patients with celiac disease has focused attention on the possibility that cryptic gluten sensitivity may be involved in the pathogenesis of MS. Here we study the effects of a gluten-free diet on the course of protracted-relapsing EAE in DA rats, serving as a preclinical model of human MS. The data show not only that this nutritional approach failed to ameliorate development of the disease but rather that it exacerbated the course.
authors.affiliation: Department of Microbiological and Gynaecological Sciences, School of Medicine, University of Catania, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Marco
authors.forename: Katia
authors.initials: K
authors.lastname: Mangano
authors.forename: Cinzia
authors.initials: C
authors.lastname: Quattrocchi
authors.forename: Filiberto
authors.initials: F
authors.lastname: Amato
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
authors.forename: Karsten
authors.initials: K
authors.lastname: Buschard
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D004032:Diet; D004035:Diet Therapy; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D005983:Glutens; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew
chemical_list: D005983:Glutens