Chlamydia pneumoniae IgG serological status and venous thromboembolism: a cross-sectional hospital based study.
OBJECTIVE
To search for a link between Chlamydia pneumoniae serological status and venous thromboembolic disease.


METHODS
From March 1992 to October 1999, we conducted a cross-sectional hospital-based study of consecutive unselected outpatients referred to us for clinical suspicion of venous thromboembolism. We compared the Chlamydia pneumoniae serological status with respectively, the venous thromboembolism, the deep vein thrombosis and the proximal deep vein thrombosis status.


RESULTS
Among 1193 patients registered for suspected venous thromboembolism, 1010 samples were available (499 negative and 511 positive patients for venous thromboembolism). Seventy-nine patients were Chlamydia pneumoniae positive. Our work failed to demonstrate any clear association between Chlamydia pneumoniae and venous thromboembolism status. Nevertheless, we identified a statistical difference regarding Chlamydia pneumoniae seropositivity and proximal vein thrombosis status (adjusted odds ratio of 1.70, CI95%: 1.05 to 2.77).


CONCLUSIONS
The presence of Chlamydia pneumoniae antibodies might be a minor risk factor for venous thrombosis.
de Saint Martin
L
L
Internal Medicine and Chest Disease Department, University Hospital of Brest, France. luc.desaintmartin@chu-brest.fr
Pasquier
E
E
Betsou
F
F
Tran
A
A
Couturaud
F
F
Orfila
J
J
D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D023521:Chlamydophila Infections / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology* / Q000302:isolation & purification; D003430:Cross-Sectional Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D020246:Venous Thrombosis / Q000453:epidemiology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G