title: Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups.
abstract: The synthesis of potential beta-turn mimetics based on cyclic sulfonamide peptoid/peptoid hybrids is described. These are readily synthesized using a solid phase protocol followed by cyclization in solution, and their suitability to combinatorial approaches is illustrated by the synthesis of a small but diversely functionalized library.
authors.affiliation: Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
authors.forename: Bas
authors.initials: B
authors.lastname: Wels
authors.forename: John A W
authors.initials: JA
authors.lastname: Kruijtzer
authors.forename: Keith M
authors.initials: KM
authors.lastname: Garner
authors.forename: Roger A H
authors.initials: RA
authors.lastname: Adan
authors.forename: Rob M J
authors.initials: RM
authors.lastname: Liskamp
mesh_terms: D003500:Cyclization; D008956:Models, Chemical; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D044105:Receptor, Melanocortin, Type 4 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D010456:Peptides, Cyclic; D044105:Receptor, Melanocortin, Type 4; D013449:Sulfonamides