Comparison of bloodstream fatty acid composition from African-American women at gestation, delivery, and postpartum.
Our aim was to examine the docosahexaenoic acid (DHA; 22:6n-3) status of pregnant African-American women reporting to the antenatal clinic at Wayne State University in a longitudinal study design. Fatty acid compositions of plasma and erythrocyte total lipid extracts were determined and food frequency surveys were administered at 24 weeks of gestation, delivery, and 3 months postpartum for participants (n = 157). DHA (mean +/- SD) in the estimated total circulating plasma was similar at gestation (384 +/- 162 mg) and delivery (372 +/- 155 mg) but was significantly lower at 3 months postpartum (178 +/- 81 mg). The relative weight percentage of DHA and docosapentaenoic acid n-6 (DPAn-6; 22:5n-6) decreased postpartum, whereas their respective metabolic precursors, eicosapentaenoic acid (EPA; 20:5n-3) and arachidonic acid (AA; 20:4n-6), increased. Similar results were found in erythrocytes. Dietary intake of DHA throughout the study was estimated at 68 +/- 75 mg/day. The relative amounts of circulating DHA and DPAn-6 were increased during pregnancy compared with 3 months postpartum, possibly via increased synthesis from EPA and AA. The low dietary intake and blood levels of DHA in this population compared with others may not support optimal fetal DHA accretion and subsequent neural development.
Stark
Ken D
KD
Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA.
Beblo
Skadi
S
Murthy
Mahadev
M
Buda-Abela
Michelle
M
Janisse
James
J
Rockett
Helaine
H
Whitty
Janice E
JE
Martier
Susan S
SS
Sokol
Robert J
RJ
Hannigan
John H
JH
Salem
Norman
N
D000328:Adult; D001741:Black or African American; D036861:Delivery, Obstetric; D004032:Diet / Q000706:statistics & numerical data; D002149:Energy Intake / Q000502:physiology; D004912:Erythrocytes / Q000737:chemistry; D005227:Fatty Acids / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006801:Humans; D049590:Postpartum Period; D011247:Pregnancy; D012016:Reference Values
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated