[Grave's disease in children with 22q11 deletion. Report of three cases].
Hypothyroidism is a well recognized complication of 22q11.2 deletion syndrome. Auto-immune hyperthyroidism is less common. We report three patients with a 22q11.2 deletion and Graves' disease diagnosed at age 17, 14 and 11 years, respectively. The clinical and biological presentation was typical for auto-immune hyperthyroidism. Graves' disease should be periodically sought during the follow-up program of patients with 22q11.2 deletion syndrome.
Gosselin
J
J
Service de médecine infantile III et de génétique clinique, hôpital d'enfants, rue du Morvan, 54511 Vandoeuvre, France.
Lebon-Labich
B
B
Lucron
H
H
Marçon
F
F
Leheup
B
B
D000293:Adolescent; D000328:Adult; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006111:Graves Disease / Q000235:genetics*; D006801:Humans; D008297:Male