title: Topographic distribution of lymphatic vessels in the normal human prostate.
abstract: BACKGROUND
  The lymphatic endothelial hyaluronan receptor (LYVE-1) is a specific cell surface protein in lymphatic endothelium. The antiserum against human LYVE-1 was developed and was confirmed a powerful marker of lymphatic endothelium in human organs. With this novel marker we investigated the small network of intraprostate lymphatic vessels.
  
  
  METHODS
  To identify intraprostatic lymphatic vessels, we performed an immunohistochemical staining method using LYVE-1 pAb and von Willebrand Factor (vWF), and assessed the difference in distribution of small lymphatic vessels between the components in the prostate.
  
  
  RESULTS
  The density of lymphatic vessel was significantly high around ejaculatory ducts and in the fibromascular area between the globular area of peripheral zone and transitional zone. Predominat lymphatic vessels distributed in the fibromascular area in the anterior and posterior prostate of extrastromal area.
  
  
  CONCLUSIONS
  Recognition of the distinctive features of the intraprostate lymphatic network, can help the investigation of lymphatic involvement in cancer of the prostate.
authors.affiliation: Department of Urology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. ssong@md.kitasato-u.ac.jp
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Soh
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Ishii
authors.forename: Erina
authors.initials: E
authors.lastname: Sato
authors.forename: Yuri
authors.initials: Y
authors.lastname: Akishima
authors.forename: Kinji
authors.initials: K
authors.lastname: Ito
authors.forename: Shiro
authors.initials: S
authors.lastname: Baba
mesh_terms: D015415:Biomarkers; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D042601:Lymphatic Vessels / Q000033:anatomy & histology* / Q000378:metabolism; D008297:Male; D009929:Organ Size; D011467:Prostate / Q000033:anatomy & histology*; D033921:Vesicular Transport Proteins
chemical_list: D015415:Biomarkers; D006023:Glycoproteins; C119248:LYVE1 protein, human; D033921:Vesicular Transport Proteins