Cytokines/chemokines and adhesion molecules in local inflammatory responses of the lung.
It is well accepted that local inflammatory responses are regulated by dynamic reactions among a variety of inflammatory cells. Most of the cells derived from bone marrow and hematopoietic cytokines play an important role in the maturation processes. Proinflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha) and IL-6 are also important in the induction of inflammatory responses. Recent progress in research, furthermore, has elucidated the critical role of chemokines and adhesion molecules in the recruitment and activation of the inflammatory cells in the lung. This article will focus on their roles in the pathogenesis of airway inflammatory disorders such as asthma.
Takizawa
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Department of Laboratory Medicine, University of Tokyo, School of Medicine, Bunkyo-ku, Japan.