title: Leucocyte phagocytosis and circulating immune complexes in mothers after child birth.
abstract: Leucocyte phagocytosis and level of circulating immune complexes (CICs) were measured in pregnant women at the three trimesters of pregnancy and in mothers 24-48 hours after child birth to evaluate the influence of pregnancy on leucocyte functions. The mothers were divided into gestation groups depending on the ages of their pregnancies as 1st trimester, 2nd trimester and 3rd trimester. The result shows that total white blood cell count (WBC), lymphocytes (B- and T-lymphocytes) and circulating immune complexes were high in pregnant women (independent of gestational ages) and mothers 24-48 hrs after child birth compared with non-pregnant controls. In contrast, mean percentage migration index (% M.I.), percentage candidacidal index (% C. I) and H2O2 production were reduced in pregnant women and mothers after child birth compared with non-pregnant controls. When test groups (pregnant women and mothers after child birth) were compared, women after child birth had least mean % C.I and %M.I while pregnant women at 1st trimester had highest mean %C. I., %M. I. and highest level of H2O2 production. Within the gestational groups, pregnant women at 3rd trimester had higher %M. I. compared with those in 2nd trimester while those in 2nd trimester had lower %M. I., %C. I. and H2O2 production compared with women at 1st trimester. Our finding shows that cell mediated immune responses vary between trimesters therefore susceptibility of pregnant women to different pathogens may vary with gestation.
authors.affiliation: Department of Chemical Pathology and Immunology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: O G
authors.initials: OG
authors.lastname: Arinola
authors.forename: K
authors.initials: K
authors.lastname: Obisesan
authors.forename: L S
authors.initials: LS
authors.lastname: Salimonu
authors.forename: R
authors.initials: R
authors.lastname: Onifade
authors.forename: K
authors.initials: K
authors.lastname: Afolabi
mesh_terms: D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology*; D008875:Middle Aged; D010587:Phagocytosis / Q000276:immunology*; D049590:Postpartum Period / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D011264:Pregnancy Trimesters / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex