title: DG-CST (Disease Gene Conserved Sequence Tags), a database of human-mouse conserved elements associated to disease genes.
abstract: The identification and study of evolutionarily conserved genomic sequences that surround disease-related genes is a valuable tool to gain insight into the functional role of these genes and to better elucidate the pathogenetic mechanisms of disease. We created the DG-CST (Disease Gene Conserved Sequence Tags) database for the identification and detailed annotation of human-mouse conserved genomic sequences that are localized within or in the vicinity of human disease-related genes. CSTs are defined as sequences that show at least 70% identity between human and mouse over a length of at least 100 bp. The database contains CST data relative to over 1088 genes responsible for monogenetic human genetic diseases or involved in the susceptibility to multifactorial/polygenic diseases. DG-CST is accessible via the internet at http://dgcst.ceinge.unina.it/ and may be searched using both simple and complex queries. A graphic browser allows direct visualization of the CSTs and related annotations within the context of the relative gene and its transcripts.
authors.affiliation: CEINGE Biotecnologie Avanzate, Naples, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Boccia
authors.forename: Mauro
authors.initials: M
authors.lastname: Petrillo
authors.forename: Diego
authors.initials: D
authors.lastname: di Bernardo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Guffanti
authors.forename: Flavio
authors.initials: F
authors.lastname: Mignone
authors.forename: Stefano
authors.initials: S
authors.lastname: Confalonieri
authors.forename: Lucilla
authors.initials: L
authors.lastname: Luzi
authors.forename: Graziano
authors.initials: G
authors.lastname: Pesole
authors.forename: Giovanni
authors.initials: G
authors.lastname: Paolella
authors.forename: Andrea
authors.initials: A
authors.lastname: Ballabio
authors.forename: Sandro
authors.initials: S
authors.lastname: Banfi
mesh_terms: D000818:Animals; D001483:Base Sequence; D003196:Computer Graphics; D017124:Conserved Sequence; D030561:Databases, Nucleic Acid; D020022:Genetic Predisposition to Disease; D023281:Genomics; D006801:Humans; D051379:Mice; D014584:User-Computer Interface