title: [Expression of telomere repeat binding factor 1 (TRF1) protein in kidney cancer].
abstract: To investigate the expression levels of telomere repeat binding factor 1(TRF1) protein in normal kidney tissue and kidney cancer.
  
  
  
  Specimens of kidney cancer and pericancerous tissues were collected from 32 cases of renal carcinoma. A quantitative Western blotting technique was developed using TRF1 monoclonal antibody to determine the expression level of TRF1 protein in total protein extracts from tissue specimens.
  
  
  
  The expression level of TRF1 protein was higher in normal kidney tissues (3.611 +/-1.922 microg/microl) than that of cancer tissues (2.428 +/-1.352 microg/microl) (t=5.776, P<0.01).
  
  
  
  The expression level of TRF1 protein is significantly reduced in kidney cancer and the level is negatively correlated with malignant degree of the cancer.
authors.affiliation: The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors.forename: Ji-min
authors.initials: JM
authors.lastname: Shi
authors.forename: Wei
authors.initials: W
authors.lastname: Ding
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.forename: Zhi-gen
authors.initials: ZG
authors.lastname: Zhang
authors.forename: Li-dan
authors.initials: LD
authors.lastname: Tang
authors.forename: Mao-fang
authors.initials: MF
authors.lastname: Lin
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D035321:Telomeric Repeat Binding Protein 1 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D035321:Telomeric Repeat Binding Protein 1