title: A major genotype in UDP-glucuronosyltransferase 2B15.
abstract: A novel single nucleotide polymorphism (SNP) was found in exon 6 of the UDP-glucuronosyltransferase (UGT) 2B15 gene from healthy Japanese populations. The SNP was as follows: SNP, 020228Toide001; GENE NAME, UGT2B15; ACCESSION NUMBER, U08854, AF180322, and NM_001078; LENGTH, 25 base; 5'-AGCTTGCCAAAAC/AAGGAAAGAAGAA-3'. This SNP was expected to cause a change of an amino acid residue at the position 523 (Thr to Lys) located in a putative co-factor binding region. The allele frequency of this SNP was 79% in Japanese, suggesting this polymorphism to be a major genotype in Japanese people.
authors.affiliation: Laboratory of Drug Metabolism, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Toide
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Umeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Terauchi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Fujii
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kamataki