Phostoxin-induced biochemical and pathomorphological changes in rabbits.
The effect of chronic phostoxin administration on some tissue ATPases, hematology and tissue histopathology was investigated using a combination of gravimetric, enzymatic, colorimetric and histological procedures in New Zealand White rabbits after 2 weeks administration of 0.8mg phostoxin/kg body weight/day, po. The phostoxin treatment led to significant decreases in Na(+)-K+ ATPase activities in renal, hepatic and cardiac tissues. Similar decreases were obtained in the activities of Ca(2+)-ATPase and Mg(2+)-ATPase in liver. In addition, the phostoxin-toxified rabbits manifested significant decreases in hematocrit, red blood cell count, hemoglobin and platelets. Histological examination of the tissues revealed pronounced degenerative changes in liver, heart and kidney.
Okolie
Ngozi Paulinus
NP
Department of Biochemistry, Faculty of Science, University of Benin, Benin City, Nigeria. ajino@uniben.edu
Aligbe
Jonathan Umezuluike
JU
Osakue
Edorisiagbon Eguagu
EE
D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D004906:Erythrocyte Count; D006321:Heart / Q000187:drug effects / Q000502:physiology; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D010575:Pesticides / Q000633:toxicity*; D010720:Phosphines / Q000633:toxicity*; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity
D017607:Aluminum Compounds; D010575:Pesticides; D010720:Phosphines; D014874:Water Pollutants, Chemical; C001864:aluminum phosphide; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase