[Protective effect of lycopene on the oxidative damage of lung in rat induced by ozone].
OBJECTIVE
To observe the effect of Lycopene (LP) on the oxidative damage of lung induced by exposing ozone.


METHODS
The injury model of lung was induced by exposing ozone. The xanthines oxidize method and TBA was used to determine SOD, MDA and GSH-Px in serum and lung respectively.


RESULTS
Compared with model rats, SOD and GSH-Px in the group of LP administrated were increased and MDA were decreased significantly (P < 0.05).


CONCLUSIONS
it was showed that LP could protect oxidative damage of lung induced by ozone in rats.
Pan
Hongzhi
H
School of Public Health, Harbin Medical University, Harbin 150001, China.
Wan
Likui
L
Sun
Shengbo
S
Na
Lixin
L
Li
Shengsan
S
Cao
Jun
J
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002338:Carotenoids / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D000077276:Lycopene; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010126:Ozone / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D002338:Carotenoids; D008315:Malondialdehyde; D010126:Ozone; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000077276:Lycopene