title: Fertilization, embryonic development and oviductal environment: role of estrogen induced oviductal glycoprotein.
abstract: Mammalian oviduct is the physiological site for sperm capacitation, gamete fertilization and early embryonic development. The secretory cells lining the lumen of the mammalian oviduct synthesize and secrete high molecular weight glycoprotein (OGP) in response to estrogen. The protein has been shown to interact with gametes and early embryo. Several key functions have been postulated particularly its role in pre-implantation events which would have far reaching implications in assisted reproductive technology and in the development of non-hormonal contraceptive vaccine. The intention of this article is to discuss the current status of the protein and analyze how far the postulated function of OGP has been borne out by the available data.
authors.affiliation: National Institute for Research in Reproductive Health, Parel, Mumbai, India.
authors.forename: Purvi
authors.initials: P
authors.lastname: Bhatt
authors.forename: Kaushiki
authors.initials: K
authors.lastname: Kadam
authors.forename: Anjana
authors.initials: A
authors.lastname: Saxena
authors.forename: Usha
authors.initials: U
authors.lastname: Natraj
mesh_terms: D000818:Animals; D047108:Embryonic Development; D004967:Estrogens / Q000494:pharmacology*; D005187:Fallopian Tubes / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D005298:Fertility / Q000502:physiology*; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans
chemical_list: D004967:Estrogens; D006023:Glycoproteins