title: Effect of parenteral antibiotic administration on establishment of intestinal colonization by Candida glabrata in adult mice.
abstract: We examined the effect of antibiotic treatment on establishment of intestinal colonization by Candida glabrata in adult mice. Subcutaneous ceftriaxone, piperacillin-tazobactam, clindamycin, and metronidazole promoted increased density of stool colonization, whereas cefepime, levofloxacin, and aztreonam did not. These findings suggest that antibiotics that inhibit intestinal anaerobes promote C. glabrata colonization.
authors.affiliation: Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA.
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: Pultz
authors.forename: Usha
authors.initials: U
authors.lastname: Stiefel
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Ghannoum
authors.forename: Marion S
authors.initials: MS
authors.lastname: Helfand
authors.forename: Curtis J
authors.initials: CJ
authors.lastname: Donskey
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D041221:Candida glabrata / Q000187:drug effects* / Q000254:growth & development*; D015169:Colony Count, Microbial; D005260:Female; D007279:Injections, Subcutaneous; D007422:Intestines / Q000382:microbiology*; D051379:Mice
chemical_list: D000900:Anti-Bacterial Agents