title: Tau modifiers as therapeutic targets for Alzheimer's disease.
abstract: Fibrillogenesis is a major feature of Alzheimer's disease (AD) and other neurodegenerative diseases. Fibers are correlated with disease severity and they have been implicated as playing a direct role in disease pathophysiology. In studies of tau, instead of finding causality with tau fibrils, we found that tau is associated with reduction of oxidative stress. Biochemical findings show that tau oxidative modifications are regulated by phosphorylation and that tau found in neurofibrillary tangles is oxidatively modified, suggesting that tau is closely linked to the biology, not toxicity, of AD.
authors.affiliation: Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA.
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
authors.forename: Hyoung-gon
authors.initials: HG
authors.lastname: Lee
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Honda
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Siedlak
authors.forename: Peggy L R
authors.initials: PL
authors.lastname: Harris
authors.forename: Adam D
authors.initials: AD
authors.lastname: Cash
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nunomura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeda
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: George
authors.initials: G
authors.lastname: Perry
mesh_terms: D000447:Aldehydes / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D006151:Guanosine / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D051379:Mice; D009410:Nerve Degeneration; D016874:Neurofibrillary Tangles / Q000737:chemistry*; D018384:Oxidative Stress; D010766:Phosphorylation; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D000447:Aldehydes; D016875:tau Proteins; D006151:Guanosine; C046215:8-hydroxyguanosine; C027576:4-hydroxy-2-nonenal