Peripheral NK cell phenotypes: multiple changing of faces of an adapting, developing cell.
We have defined the existence of developmental relationships among human peripheral NK cells with distinct phenotypic and functional characteristics. These findings closely parallel the changes that occur in vivo during NK cell development, and in vitro in experimental culture systems supporting NK cell generation from hematopoietic progenitors. These new insights provide a simplified framework to understand NK cell immunobiology and the cellular bases for their roles in innate immunity, initiation and maintenance of immune responses via regulation of adaptive and accessory cell functions, and immune pathologies.
Perussia
Bice
B
Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA. bice.perussia@mail.tju.edu
Chen
Yingying
Y
Loza
Matthew J
MJ
D015703:Antigens, CD / Q000276:immunology; D002454:Cell Differentiation; D016207:Cytokines / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D010641:Phenotype
D015703:Antigens, CD; D016207:Cytokines