[Therapeutic strategies and prospects of gliomas].
The prognosis and the treatment of gliomas depend on age, performance status and histological grade. Symptomatic treatment relies on steroids against cerebral edema, anti-epileptic drugs for seizures and perioperatively, prevention of thrombo-embolism and digestive complications, physiotherapy. Specific therapies include surgery, radiotherapy and chemotherapy. Surgery is necessary for histological diagnosis. In low grade gliomas, it has a significant impact in terms of survival. In malignant gliomas, surgery provides symptomic relief without clearly improving survival. Radiation therapy has been shown to improve survival in malignant glioma, but not in asymptomatic low grade tumors. Chemotherapy has a modest efficacy in glioblastomas, whereas oligodendrogliomas with 1p 19q deletion are chemosensitive tumors.
Taillibert
Sophie
S
Fédération de neurologie Mazarin, Bâtiment Mazarin, Höpital Salpétrière, 47-83 bd de l'Hôpital, 75013, Paris.
Pedretti
Marta
M
Sanson
Marc
M
D000367:Age Factors; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D005910:Glioma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D006304:Health Status; D006801:Humans; D009367:Neoplasm Staging / Q000379:methods*; D011379:Prognosis; D016019:Survival Analysis
D000970:Antineoplastic Agents