title: Screening of bioactive metabolites for pancreatic regeneration chemotherapy.
abstract: Plants and microorganisms are the treasury of bioactive metabolites including useful chemical ligands. Chemical ligands that induce beta-cell differentiation may be useful as new therapeutic agents for both type-1 and type-2 diabetes mellitus. We isolated conophylline from the leaves of Ervatamia microphylla as an agent that induce insulin production in rat pancreatic acinar carcinoma cells.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-0061, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takatsuna
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umezawa
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D010179:Pancreas / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D012038:Regeneration / Q000187:drug effects* / Q000502:physiology