title: The traditional Chinese medicine Cordyceps sinensis and its effects on apoptotic homeostasis.
abstract: Cordyceps sinensis is a medicinal fungus of Traditional Chinese Medicine. While there are a wide range of reported uses of Cordyceps sinensis in the literature, the reports that extracts of this fungus may alter apoptotic homeostasis are most intriguing. However, there are significant challenges regarding research surrounding Cordyceps sinensis, such as the difficulty identifying the various species of Cordyceps and the many conflicting reports of pharmacological function in the literature. In this review we outline what is known about the ability of Cordyceps sinensis to alter apoptotic homeostasis, attempt to reconcile the differences in reported function, identify the challenges surrounding future Cordyceps sinensis research, and delineate options for overcoming these critical hurdles.
authors.affiliation: Complementary and Integrative Medicine Program, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Buenz
authors.forename: B A
authors.initials: BA
authors.lastname: Bauer
authors.forename: T W
authors.initials: TW
authors.lastname: Osmundson
authors.forename: T J
authors.initials: TJ
authors.lastname: Motley
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001688:Biological Products / Q000627:therapeutic use; D032661:Cordyceps; D006801:Humans; D008516:Medicine, Chinese Traditional
chemical_list: D001688:Biological Products