title: Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist.
abstract: The discovery of a novel, potent and selective beta(3)-adrenergic receptor (AR) agonist is described. SAR studies demonstrated the structural requirements for activity and selectivity. Compound 1c, which showed good beta(3)-AR activity and selectivity, was identified and pharmacokinetics were investigated.
authors.affiliation: Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, 1-6, Kashima 2-Chome, Yodogawa-Ku, Osaka 532-8514, Japan. yutaka_nakajima@po.fujisawa.jp
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hamashima
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Washizuka
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Tomishima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohtake
authors.forename: Emiko
authors.initials: E
authors.lastname: Imamura
authors.forename: Toshiko
authors.initials: T
authors.lastname: Miura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kayakiri
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kato
mesh_terms: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D008956:Models, Chemical; D013329:Structure-Activity Relationship
chemical_list: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists