Bismuth triflate-catalyzed three-component mannich-type reaction.
Bismuth triflate catalyzes the Mannich-type reaction of a variety of in situ generated aldimines using aldehydes, anilines, and silyl enol ethers in a three-component reaction. The reaction proceeds rapidly and affords the corresponding protected beta-amino ketones in high yields (up to 94%).
Ollevier
Thierry
T
Département de chimie, Université Laval, Québec, Canada G1K 7P4. thierry.ollevier@chm.ulaval.ca
Nadeau
Etienne
E