Correlation between antemortem magnetic resonance imaging findings and pathologically confirmed corticobasal degeneration.
BACKGROUND
Slowly progressive asymmetric parkinsonism and cortical dysfunction clinically characterize corticobasal syndrome (CBS). Various pathologic findings, including corticobasal degeneration (CBD), progressive supranuclear palsy, and frontotemporal degenerations, underlie CBS.


OBJECTIVE
To determine if regional cortical and corpus callosum atrophy and subcortical and periventricular white matter (SPWM) signal changes on head magnetic resonance imaging were specific to CBD.


METHODS
Historical review of autopsy cases.


METHODS
Subspecialized behavioral neurology and movement disorder clinics within a neurology department of a tertiary referral center.


METHODS
Seventeen patients with CBS who had an autopsy-confirmed diagnosis of CBD or another neurodegenerative disease.


METHODS
Regional cerebral cortical atrophy, regional corpus callosum atrophy, and SPWM signal changes.


RESULTS
Similar patterns of regional atrophy and SPWM signal changes were found in the patients with autopsy-proven CBD and in the patients with other neurodegenerative diseases.


CONCLUSIONS
Neither cortical nor corpus callosum atrophy nor SPWM signal changes on head magnetic resonance imaging are specific to CBD.
Josephs
Keith A
KA
Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. josephs.keith@mayo.edu
Tang-Wai
David F
DF
Edland
Steven D
SD
Knopman
David S
DS
Dickson
Dennis W
DW
Parisi
Joseph E
JE
Petersen
Ronald C
RC
Jack
Clifford R
CR
Boeve
Bradley F
BF
D000368:Aged; D001284:Atrophy / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000473:pathology*; D018709:Statistics, Nonparametric