title: Concurrent hepatic and ruptured renal angiomyolipoma in tuberous sclerosis complex.
abstract: Angiomyolipoma of the liver or kidney is one of the clinical manifestations of tuberous sclerosis complex. However, concurrence of angiomyolipoma in both liver and kidney associated with tuberous sclerosis complex is a rare entity. Renal angiomyolipomas with large aneurysms confer a higher probability of rupture as compared to small aneurysms. Herein, we document a case of tuberous sclerosis coexisting with hepatic and renal angiomyolipoma in a 37 year-old woman who presented with an acute abdomen due to ruptured tumor. Computed tomography of the abdomen revealed multiple tumors over the bilateral kidneys and liver. A right nephrectomy was performed. During surgery, a liver biopsy was performed from which a preliminary diagnosis of necrosis was established. However, immunoreactivity staining using monoclonal antibody HMB-45 (Human Melanoma, Black) led to the final diagnosis of angiomyolipoma. We emphasized that pathologists and clinicians should be aware that cases of tuberous sclerosis complex may be associated with renal and hepatic angiomyolipoma. To avoid an inappropriate diagnosis, before diagnosing liver necrosis, immunohistochemical staining for HMB-45 is recommended.
authors.affiliation: Division of Nephrology, Hsin-Chu Hospital, Department of Health, The Executive Yuan, Hsin Chu, Taiwan.
authors.forename: Cheng-Han
authors.initials: CH
authors.lastname: Chao
authors.forename: Chin-Yew
authors.initials: CY
authors.lastname: Lin
authors.forename: Siu-Cheung
authors.initials: SC
authors.lastname: Chan
authors.forename: Kuo-Su
authors.initials: KS
authors.lastname: Chen
mesh_terms: D015746:Abdominal Pain / Q000209:etiology / Q000601:surgery; D000328:Adult; D018207:Angiomyolipoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D000951:Antigens, Neoplasm; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis; D009392:Nephrectomy; D014057:Tomography, X-Ray Computed; D014402:Tuberous Sclerosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins