Inhibition of osteoporosis due to restricted food intake by the fish oils DHA and EPA and perilla oil in the rat.
Seven-week old female rats fed restricted foods including the fish oils Docosahesaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) and perilla oil with food intake decreased by 50%, had increases of fracture force and bone mineral density (BMD) and decreases in levels of Deoxypiridinoline (Dpd) and Calcium (Ca) in the urine, compared with those of rats with osteoporosis due to restricted soy bean oil food intake. Therefore, the fish oils DHA and EPA and perilla oil depressed excretion of urinary Ca and inhibited osteoporosis due to restricted food intake.
Sun
Liman
L
Laboratories of Applied Biochemistry, Faculty of Agriculture, University of the Ryukyus, Senbaru 1, Nishihara-cho, Okinawa 903-0213, Japan.
Tamaki
Hajime
H
Ishimaru
Tetsuji
T
Teruya
Tomokazu
T
Ohta
Yutaka
Y
Katsuyama
Naofumi
N
Chinen
Isao
I
D000596:Amino Acids / Q000652:urine; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects; D002118:Calcium / Q000652:urine; D004032:Diet; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000494:pharmacology; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005269:Femur; D005395:Fish Oils / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D050723:Fractures, Bone / Q000517:prevention & control; D010024:Osteoporosis / Q000517:prevention & control*; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013024:Soybean Oil / Q000008:administration & dosage / Q000494:pharmacology; D017962:alpha-Linolenic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
D000596:Amino Acids; D005395:Fish Oils; D010938:Plant Oils; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids; C058216:perilla seed oil; D013024:Soybean Oil; C036020:deoxypyridinoline; D015118:Eicosapentaenoic Acid; D002118:Calcium