title: Osteochondritis dissecans of the talus treated by the transplantation of tissue-engineered cartilage.
abstract: Management of osteochondral lesions of the joint has been difficult, because articular cartilage has a poor healing capacity as a result of its lack of vessels, nerve supply, and its isolation of systemic regulation. Although a lot of basic research and surgical treatments for cartilage repair have focused on osteochondral lesions in the knee joint, orthopedic surgeons have recently diverted their attention to osteochondral lesions in the ankle joint, partly because of the widespread introduction of arthroscopy in ankle surgery. There have been many attempts to treat articular cartilage defects in the ankle joint as well as in the knee joint. However, no treatment has achieved efficient healing with hyaline cartilage. Recently, tissue engineering technique for cartilage repair has been gaining much attention in the orthopedic field. In this study, we reported on a patient with osteochondritis dissecans of the talar dome, successfully treated by transplantation of tissue-engineered cartilage made ex vivo using atelocollagen gel and low tibial osteotomy.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Agung
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Ochi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Adachi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Uchio
authors.forename: Masato
authors.initials: M
authors.lastname: Takao
authors.forename: Kenzo
authors.initials: K
authors.lastname: Kawasaki
mesh_terms: D000328:Adult; D000843:Ankle Joint; D002356:Cartilage / Q000637:transplantation*; D005260:Female; D006801:Humans; D010008:Osteochondritis Dissecans / Q000601:surgery*; D023822:Tissue Engineering; D014180:Transplantation / Q000379:methods