title: Positive and negative symptom profile schizophrenia and abnormalities in the P300 component of the event-related potential: a longitudinal controlled study.
abstract: The relationship between symptoms of schizophrenia and abnormalities in the P300 component of the event-related potential (ERP) was investigated in 22 and 27 patients diagnosed with positive and negative profile schizophrenia, respectively. The Positive and Negative Syndrome Scale (PANSS) was used to characterize clinical symptoms. A group of 30 normal controls were also studied. Results showed that patients with schizophrenia exhibited reduced P300 amplitudes compared with controls and that those with negative profile schizophrenia had amplitude decrements and longer latencies. These findings suggest that there are neurobiological differences between positive and negative profile schizophrenia.
authors.affiliation: Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. zheningl@hotmail.com
authors.forename: Zhening
authors.initials: Z
authors.lastname: Liu
authors.forename: Wai-Cheong Carl
authors.initials: WC
authors.lastname: Tam
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Xue
authors.forename: Shuqiao
authors.initials: S
authors.lastname: Yao
authors.forename: Daxing
authors.initials: D
authors.lastname: Wu
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D039721:Diagnostic and Statistical Manual of Mental Disorders; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index