title: Production of chemokines in Kawasaki disease, Henoch-Schönlein purpura and acute febrile illness.
abstract: We compared the production of three chemokines; interferon-gamma-inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and growth-related onco-gene-alpha(Gro-alpha) that attracts monocytes or neutrophils, or both, in peripheral blood at acute stage of Kawasaki disease (n=29), Henoch-Schönlein purpura (n=15) and acute febrile illnesses (n=12). The production of the chemokines was assayed by ELISA. The plasma levels of IP-10 were markedly elevated in Kawasaki disease (538.6+/-336.4 pg/mL) and acute febrile illnesses (417.1 +/-262.2 pg/mL) compared with in Henoch-Schönlein purpura (58.7 +/-95.7 pg/mL) (p<0.05). The MCP-1 levels were elevated in Kawasaki disease (443.0 +/-473.1 pg/mL) and acute febrile illnesses (328.6 +/-261.1 pg/mL) compared with in Henoch-Schönlein purpura (82.9 +/-79.0 pg/mL) (p<0.05). The Gro-alpha levels were elevated only in acute febrile illnesses (134.3 +/-153.6 pg/mL) compared with in Kawasaki disease (31.8 +/-22.1 pg/mL) or Henoch-Schönlein purpura (29.4 +/-53.3 pg/mL) (p<0.05). According to these results, monocytes may play an important role in Kawasaki disease. In acute febrile illnesses, both monocytes and neutrophils may play an important role. By contrast, Henoch-Schönlein purpura may not be associated with the role of monocytes and neutrophils. Further studies using a larger number of cases are needed.
authors.affiliation: Department of Pediatrics, Yeungnam University, College of Medicine, Daegu, Korea.
authors.forename: Hyo Seok
authors.initials: HS
authors.lastname: Chung
authors.forename: Hyo Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Hee Sun
authors.initials: HS
authors.lastname: Kim
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Yuh
authors.forename: Eun Sil
authors.initials: ES
authors.lastname: Lee
authors.forename: Kwang Hae
authors.initials: KH
authors.lastname: Choi
authors.forename: Young Hwan
authors.initials: YH
authors.lastname: Lee
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D018925:Chemokines / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood* / Q000453:epidemiology*; D007231:Infant, Newborn; D007723:Korea / Q000453:epidemiology; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000453:epidemiology*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
chemical_list: D018925:Chemokines