Vaccination with purified Dr Fimbriae reduces mortality associated with chronic urinary tract infection due to Escherichia coli bearing Dr adhesin.
The vaccination of C3H/HeJ mice with Escherichia coli Dr fimbrial antigen reduced mortality associated with an experimental urinary tract infection due to a homologous strain bearing Dr adhesin. Immune sera with high titers of anti-Dr antibody inhibited bacterial binding to bladders and kidneys but did not affect the rate of renal colonization.
Goluszko
Pawel
P
University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1062, USA. pgoluszk@utmb.edu
Goluszko
Elzbieta
E
Nowicki
Bogdan
B
Nowicki
Stella
S
Popov
Vsevolod
V
Wang
Hui-Qun
HQ
D018830:Adhesins, Escherichia coli / Q000502:physiology*; D000818:Animals; D002908:Chronic Disease; D004927:Escherichia coli Infections / Q000517:prevention & control*; D029968:Escherichia coli Proteins / Q000276:immunology*; D005260:Female; D036781:Fimbriae Proteins / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D014552:Urinary Tract Infections / Q000517:prevention & control*; D014611:Vaccination
D018830:Adhesins, Escherichia coli; D029968:Escherichia coli Proteins; D036781:Fimbriae Proteins