[Investigation of antioxidant therapy with sodium selenite in acute pancreatitis. A prospective randomized blind trial].
OBJECTIVE
Oxygen free radicals appear in the early phase of acute pancreatitis followed by an imbalance between the oxygen and anti-oxygen system. Sodium selenite may play an important role in the reduction of radicals in experimental pancreatitis. The aim of this study was to evaluate the effects of selenium in a clinical prospective trial.


METHODS
70 patients with acute pancreatitis were prospectively allocated to a selenium and a placebo group. Clinical and paraclinical parameters were investigated with a follow-up of 90 days after hospital stay.


RESULTS
The clinical course of the two treatment groups did not show statistically significant differences. Five patients in the selenium and three patients in the placebo group died. Depending on selenium therapy, antioxidant substances were presented in higher levels. All 17 clinical parameters showed no statistical significance.


CONCLUSIONS
Substitution of sodium selenite has no beneficial effect on the clinical outcome of patients with acute pancreatitis.
Lindner
Dirk
D
Medizinische Klinik Flemmingstrasse der Klinikum Chemnitz gGmbH, Chemnitz.
Lindner
Joachim
J
Baumann
Gunter
G
Dawczynski
Horst
H
Bauch
Karlheinz
K
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000188:drug therapy*; D011446:Prospective Studies; D018038:Sodium Selenite / Q000627:therapeutic use*; D016896:Treatment Outcome
D000975:Antioxidants; D018038:Sodium Selenite