title: [Clinical and pathological analysis of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome].
abstract: OBJECTIVE
  To explore clinical and histopathological characteristics of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome.
  
  
  METHODS
  Clinical data and pathological findings of 10 patients were reviewed.
  
  
  RESULTS
  Serum glutamine transpeptidase,alkaline phosphatase levels,alanine transaminase, aspartate transaminase, serum IgG and IgM were elevated in all the patients. They were all positive for anti-mitochondrial antibody and AMA-M2. Nine patients were positive for anti-nuclear antibody and one patient was positive for anti liver-kidney microsome antibody. Liver biopsies in these patients revealed: ten patients had bile duct lesion,hepatitis activities ranged from moderate to severe, and fibrosis ranged from S1 to S3.
  
  
  CONCLUSIONS
  PBC-AIH overlap syndrome is mostly found in middle-aged women. It has the clinical and histopathological characteristics of both PBC and AIH. Accurate and prompt diagnosis of overlap syndrome patients should be based on the clinical presentation,biochemical and immune indexes,and hepatic pathological changes.
authors.affiliation: Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China. howard 1@263.net
authors.forename: Chi-hong
authors.initials: CH
authors.lastname: Wu
authors.forename: Xiao-yuan
authors.initials: XY
authors.lastname: Xu
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Lu
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Yu
authors.forename: Gui-qiang
authors.initials: GQ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008105:Liver Cirrhosis, Biliary / Q000150:complications / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000276:immunology; D012189:Retrospective Studies; D013577:Syndrome; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase