Shiga-toxigenic Escherichia coli-inoculated neonatal piglets develop kidney lesions that are comparable to those in humans with hemolytic-uremic syndrome.
Kidney lesions similar to those in humans with hemolytic-uremic syndrome were observed histologically in 82 of 122 piglets inoculated intragastrically with Shiga-toxigenic Escherichia coli but not in 29 controls. The locations of lesions matched locations where Stx-2 binding and Gb3 (globotriasylceramide receptors for Stx) were identified immunohistochemically.
Pohlenz
J F
JF
National Animal Disease Center, USDA, ARS, P.O. Box 70, Ames, IA 50010-0070, USA.
Winter
K R
KR
Dean-Nystrom
E A
EA
D000818:Animals; D000831:Animals, Newborn; D004926:Escherichia coli / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000473:pathology*; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology*; D012189:Retrospective Studies; D022641:Shiga Toxin 2 / Q000378:metabolism / Q000633:toxicity*; D013552:Swine; D014281:Trihexosylceramides / Q000378:metabolism
D022641:Shiga Toxin 2; D014281:Trihexosylceramides; C018549:globotriaosylceramide