title: Bowenoid papulosis in a patient with AIDS treated with imiquimod: case report.
abstract: A 53-year-old male patient with acquired immunodeficiency syndrome (AIDS) was treated with topical immunomodulator imiquimod for bowenoid papular. Clinically the lesions presented as condilomatous and papulous changes with color varying from skin color to grayish. The lesions were located in the glans and in the dorsum of the penis. Clinical diagnosis was confirmed by histopathological examination, and the polymerase chain reaction (PCR) demonstrated the presence of human papilloma virus (HPV) 16. It was decided to apply a topical treatment with imiquimod 5% cream three times a week for 16 weeks. Almost complete regression was obtained; the residual lesions were treated with a combined chemical cauterization by using 50% trichloroacetic acid followed by 25% podophylin. Although it is not a definitive treatment, the use of topical immunomodulator is one more therapeutic option in the selected HPV cases.
authors.affiliation: Sector of Dermatology, HUCFF-UFRJ and School of Medicine, Rua Sorocaba 464/205 22271-110 Rio de Janeiro, Brasil.
authors.forename: Mariana de Gusmăo
authors.initials: Mde G
authors.lastname: Nunes
authors.forename: Beatriz Moritz
authors.initials: BM
authors.lastname: Trope
authors.forename: Silvia Maria Baeta
authors.initials: SM
authors.lastname: Cavalcanti
authors.forename: Ledy do Horto Dos Santos
authors.initials: Ldo H
authors.lastname: Oliveira
authors.forename: Marcia
authors.initials: M
authors.lastname: Ramos-e-Silva
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000634:Aminoquinolines / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001913:Bowen's Disease / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D000077271:Imiquimod; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications; D010413:Penis; D012611:Scrotum; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000821:virology
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod