title: [Hepatitis B and C virus infection and the hepatocellular carcinoma in the East Amazon, Brazil].
abstract: In order to contribute to a better understanding of the possible role of hepatits B and C in the etiopathogenis of HCC in the East Amazon, there were studied 36 patients in Belém/PA. Serological hepatitis markers were evaluated and polymerase chain reaction assays were used to detect HBV-DNA and HCV-RNA. Alcohol abuse was observed in 33.3% and cirrhosis in 83.3%. In 88.9% of the sample, one or more hepatitis B markers were positive. Also, 8.3% those patients had anti-HCV simultaneously positive. The HBsAg serological test was positive in 58.3%; anti-HBc in 86%; anti-HBe in 85.7%; anti-HBe in 9.5%; IgM anti-HBc in 57.1%. The HBV DNA was found in 37.7% and in 65% of the HBsAg positive. The HCV RNA was detected in 8.5% and in 100% of the patients positive to anti-HCV. The AFP was above the normal value in 88.9% of patients, with levels up to 400ng/ml in 75% of them. In conclusion, hepatitis B virus infection seems to be important in the etiology of HCC and improving measures such immunization and screening in the risk population should be emphasyzed.
authors.affiliation: Programa de Hepatopatias Crônicas da Fundação Hospital Santa Casa de Misericórdia do Pará, Belém, PA. miranda@amazon.com.br
authors.forename: Esther Castello Branco Mello
authors.initials: EC
authors.lastname: Miranda
authors.forename: Lizomar de Jesus Pereira
authors.initials: Lde J
authors.lastname: Moia
authors.forename: Ivanete do Socorro Abraçado
authors.initials: Ido S
authors.lastname: Amaral
authors.forename: Maria Silvia de Brito
authors.initials: MS
authors.lastname: Barbosa
authors.forename: Simone Regina Souza da Silva
authors.initials: SR
authors.lastname: Conde
authors.forename: Marialva Tereza Ferreira
authors.initials: MT
authors.lastname: de Araújo
authors.forename: Ermelinda do Rosário Moutinho
authors.initials: Edo R
authors.lastname: da Cruz
authors.forename: Samia
authors.initials: S
authors.lastname: Demachki
authors.forename: Gilberta
authors.initials: G
authors.lastname: Bensabath
authors.forename: Manoel do Carmo Pereira
authors.initials: Mdo C
authors.lastname: Soares
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001938:Brazil; D006528:Carcinoma, Hepatocellular / Q000821:virology*; D002648:Child; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000150:complications*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D008113:Liver Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis
chemical_list: D015415:Biomarkers; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D012367:RNA, Viral