[Initial discussion of mice acute hepatic injury caused by Tripterygium glycosides].
OBJECTIVE
To discuss the mechanism of mice acute hepatic injury caused by tripterygium glycosides tablets with different dose at different time.


METHODS
Mice were given Tripterygium Glycosides respectively with the dosage of 10 times, 20 times, 30 times of clinical dose to observe the change of mice acute hepatic injury with different does; then, the acute hepatic injury mice were duplicated with 20 times clinical dosage and mice serum ALT were detected at 9, 18, 27, 36 h to observe the change of mice acute hepatic injury at different time. The activity of SOD, GSH-Px in serum and the level of LPO in liver homogenate wevedetected to discuss the mechanism of mice acute hepatic injury caused by Tripterygium Glycosides tablets; and liver tissue pathology was observed.


RESULTS
The acute hepatic injury was obvious with 20 times adult dosage in 18 hours and the acute hepatic injury mice death rate was low.


CONCLUSIONS
Tripterygium Glycosides tablets can cause acute hepatic injury to mice and its mechanism is related to Lipid peroxidation reaction.
Peng
Bo
B
Hepatopathy Institute of Henan Traditional Chinese Medicine, Zhengzhou 450008, Henan, China. pbsir@sina.com
Miao
Ming-san
MS
Wang
Yu-liang
YL
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006027:Glycosides / Q000302:isolation & purification / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors; D029757:Tripterygium / Q000737:chemistry
D006027:Glycosides; D008054:Lipid Peroxides; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000410:Alanine Transaminase