Case of chronic lymphocytic leukemia with unusual chromosome aberrations.
Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome banding analysis and confirmed by fluorescence in situ hybridization analysis of interphase cells. Because of the rarity of these changes, possible molecular mechanisms associated with this karyotype are discussed.
Hsiao
Hui-Hua
HH
Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Hung
Yi-Hui
YH
Hsiao
Hui-Pin
HP
Tseng
Shih-Bin
SB
Tsai
Hui-Jen
HJ
Liu
Yi-Chang
YC
Liu
Ta-Chih
TC
Chao
Mei-Chyn
MC
Chang
Yuli
Y
Lin
Sheng-Fung
SF
D000368:Aged; D002892:Chromosomes, Human, Pair 22; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D017809:Fatal Outcome; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic