The intelligent data management system for toxicogenomics.
Toxicogenomics is now emerging as one of the most important genomic application because the toxicity test based on gene expression profiles is expected to be more precise and efficient than current histopathological approaches in a pre-clinical phase. One of the challenging issues in toxicogenomics is the construction of intelligent database management system which can deal with heterogeneous and complex data from many different experimental and information sources. TEST(Toxicogenomics for Efficient Safety Test) database is especially focused on the connectivity of heterogeneous data and the intelligent query system which enable users to obtain relevant useful information from the complex data sets. The database deals with four kinds of information; compound, histopathology, gene expression, and annotation information. Currently, TEST database maintains toxicogenomics information for 16 compounds, 45 microarrays, 190 animal experiments, and customized 4.8 K rat clone set. Our presented system is expected to be a good information source for studying of toxicology mechanism in the genome-wide level and can also be applied to the designing toxicity test chip.
Lee
Wan-Seon
WS
Bioinformatics Unit, ISTECH Inc., Goyang, Gyeonggi-do, South Korea.
Lee
Gyoum-Jung
GJ
Lee
Gyoung-Jae
GJ
Yeo
Chan-Dong
CD
Kang
Jong-Soo
JS
Kim
Yong-Hyun
YH
Kim
Seung-Jun
SJ
Kim
Jun-Sub
JS
Hwang
Seung Yong
SY
Park
Joon-Suk
JS
Hwang
Jae-Woong
JW
Kang
Kyung-Sun
KS
Lee
Yong-Soon
YS
Jeon
Ki-Seon
KS
Um
Chan-Hwi
CH
Hong
Seok-Il
SI
Kim
Yang-Seok
YS
D000818:Animals; D016208:Databases, Factual; D043922:Toxicogenetics