title: Genotoxicity of vegetable cooking oils in the Drosophila wing spot test.
abstract: Seven vegetable oils consumed by humans were tested for genotoxic activity in the Drosophila somatic mutation and recombination test. The oils included five seed oils (sesame, sunflower, wheat germ, flax, and soy oil) and both first-class extra-virgin and low-grade (refined) olive oil. Larvae of the standard (STD) and highly bioactive (NORR) crosses of Drosophila melanogaster were fed medium containing 6% and 12% of each of the oils. Flax oil produced the strongest response, while sesame, wheat germ, and soy oil showed some genotoxic activity. Sunflower and the low-grade olive oil gave inconclusive results, and extra-virgin olive oil was clearly nongenotoxic. It is argued that the genotoxicity is probably due to the fatty acid composition of the oils, which after peroxidation can form specific DNA-adducts.
authors.affiliation: Department of Genetics, University of Córdoba, Córdoba, Spain.
authors.forename: Mar
authors.initials: M
authors.lastname: Rojas-Molina
authors.forename: Juan
authors.initials: J
authors.lastname: Campos-Sánchez
authors.forename: Mohamed
authors.initials: M
authors.lastname: Analla
authors.forename: Andrés
authors.initials: A
authors.lastname: Muñoz-Serrano
authors.forename: Angeles
authors.initials: A
authors.lastname: Alonso-Moraga
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics; D019597:Flax; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity; D000069463:Olive Oil; D010938:Plant Oils / Q000633:toxicity*; D012715:Sesame Oil; D013024:Soybean Oil
chemical_list: D009153:Mutagens; D000069463:Olive Oil; D010938:Plant Oils; C050055:wheat germ oil; D013024:Soybean Oil; D012715:Sesame Oil