L-Arginine treatment for asymmetric fetal growth restriction.
OBJECTIVE
[corrected] To investigate the effects of L-Arginine in treating asymmetric fetal growth restriction (FGR).


METHODS
A total of 66 pregnant women whose fetuses were diagnosed with asymmetric fetal growth restriction were divided into two groups. Group 1 consisted of 36 women who were given routine therapy alone; group 2 consisted of 30 women who were given L-Arginine and routine therapy; and the control group consisted of 30 more women with a normal pregnancy.


RESULTS
Before treatment, mean maternal serum levels of NO2-/NO3- were significantly lower in groups 1 and 2 than in the control group (P<0.01). After treatment, maternal serum levels of NO2-/NO3- were considerably higher in group 2 than in group 1 (P<0.01). Mean birth weight was significantly higher in group 2 than in group 1 (P<0.05), but still lower in group 2 than in the control group (P<0.01).


CONCLUSIONS
A deficiency in nitric oxide may play an important role in the development of asymmetric fetal growth restriction. L-Arginine can be used to increase maternal NO2-/NO3- levels and newborn birth weight.
Xiao
X M
XM
Department of Gynecology/Obstetrics, First Affiliated Hospital of Jinan University, Guangzhou, China.
Li
L P
LP
D000328:Adult; D001120:Arginine / Q000627:therapeutic use*; D001724:Birth Weight; D005317:Fetal Growth Retardation / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D009569:Nitric Oxide / Q000097:blood; D014469:Umbilical Arteries / Q000737:chemistry
D009569:Nitric Oxide; D001120:Arginine