title: Rupture of the gallbladder in a patient with acquired factor VIII inhibitors and systemic lupus erythematosus.
abstract: A 54-year-old woman with a 21-year history of systemic lupus erythematosus (SLE) was admitted to the Matsuyama Red Cross Hospital due to subcutaneous and gingival hemorrhaging. She was diagnosed with acquired factor VIII inhibitors based on a prolonged activated partial-thromboplastin time (APTT) and factor VIII inhibitors. Steroid pulse and factor VIII plasma concentrate were administered to her, not long after which she was transferred to Ehime University Hospital due to gallbladder hematoma. Although her APTT and factor VIII activity were improved after treatment with human factor VIII, she died of multiple organ failure. The autopsy demonstrated a ruptured gallbladder.
authors.affiliation: First Department of Internal Medicine, Ehime University Hospital, Ehime.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Onishi
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Hojo
authors.forename: Ikuya
authors.initials: I
authors.lastname: Sakai
authors.forename: Masaki
authors.initials: M
authors.lastname: Yasukawa
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hato
authors.forename: Youko
authors.initials: Y
authors.lastname: Minamoto
authors.forename: Eisuke
authors.initials: E
authors.lastname: Yokota
authors.forename: Mitsuko R
authors.initials: MR
authors.lastname: Ito
authors.forename: Kentaro
authors.initials: K
authors.lastname: Dote
authors.forename: Ichiro
authors.initials: I
authors.lastname: Shimizu
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fujita
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001774:Blood Chemical Analysis; D001780:Blood Coagulation Tests; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D017809:Fatal Outcome; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000473:pathology; D005705:Gallbladder Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000401:mortality; D006467:Hemophilia A / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008875:Middle Aged; D012422:Rupture, Spontaneous; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; D005169:Factor VIII