[Glomeruli manifestation of hepatitis C virus infection].
The purpose of this study was to explore the relationship between hepatitis C virus (HCV) infection and glomerulonephritis. Renal autopsy tissues taken from 21 patients with HCV infection were examined by immunohistochemical technique (S-P assay) with monoclonal anti-HCV NS3 and anti-HCV NS5. Results showed that HCAg positivity were detected in 13 out of 21 renal tissues (61.9%). 11 and 1 out of 13 were identified as membranoproliferative glomerulonephritis (MPGN) and mesangial proliferative glomerulonephritis (MsPGN) respectively, and another 1 case did not show obvious lesion. 8 out of 21 cases were negative for HCAg, in which MsPGN and membranous glomerulonephritis (MN) as well as postinfectious glomerulonephritis (PSGN) were identified in 2 and each in 1 case, respectively, except another 4 cases with no obvious lesion. The renal lesion were more common and diverse in HCV associated glomerulonephritis than hepatitis B virus (HBV) associated glomerulonephritis, the show of clinical data were similar between the two. There was HCV related glomerulonephritis and the clinical manifestation may present relevantly.
Guo
X
X
You An Hospital, Beijing 100054.
Zhang
T
T
D005260:Female; D005921:Glomerulonephritis / Q000473:pathology / Q000821:virology*; D016174:Hepacivirus / Q000378:metabolism; D006526:Hepatitis C / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D017361:Viral Nonstructural Proteins / Q000378:metabolism; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; D012324:RNA-Dependent RNA Polymerase
D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase