title: Postexercise left ventricular function and cTnT in recreational marathon runners.
abstract: OBJECTIVE
  To assess the impact of prolonged exercise on left ventricular (LV) function and the appearance of cardiac troponin T (cTnT) in older and recreational athletes.
  
  
  METHODS
  Heart rate (HR), blood pressures, and cTnT were recorded in 35 subjects (age range 22-57 yr, finishing time 157-341 min) pre- and postrace. Echocardiograms (N = 26) assessed stroke volume (SV), ejection fraction (EF), sBP/LV end-systolic volume (sBP/ESV), diastolic filling (E:A ratio) as well as preload (LV internal dimension at end-diastole [LVIDd]) and afterload (LV wall stress). HR and core temperature were recorded in-event. Prepost changes in LV function were analyzed by repeated measures t-test. Delta scores for LV function and cTnT data were correlated with each other, age, finishing time, alterations in loading, and in-event data.
  
  
  RESULTS
  SV was significantly decreased postrace (109 +/- 31 vs 85 +/- 25 mL, P < 0.05) likely due to a significant decrease in LVIDd (5.3 +/- 0.4 vs 4.9 +/- 0.5 cm, P < 0.05; r = 0.80, P < 0.05). LV wall stress was unchanged postrace (90 +/- 25 vs 89 +/- 27 g x cm(-2), P > 0.05). EF (70 +/- 12 vs.70 +/- 10%, P > 0.05) and sBP/ESV (3.7 +/- 2.9 vs 4.0 +/- 2.0, P > 0.05) did not change prepost race and were not related to age or finishing time (P > 0.05). E:A ratio was significantly reduced postrace (1.73 +/- 0.38 vs 1.41 +/- 0.25, P < 0.05) and could not be explained by an increased HR (56 +/- 9 vs 84 +/- 10, P < 0.05; r = 0.08, P > 0.05), a reduced LVIDd (r = 0.11, P > 0.05), age, finishing time, or in-event data. Postrace 26/33 subjects presented cTnT values in the range 0.024-0.080 microg x L(-1) that were not related to changes in LV function, loading, age, finishing time, or in-event data.
  
  
  CONCLUSIONS
  No evidence of load-independent depression in LV systolic function was reported. Changes in cTnT and E:A were not related, and their etiology is uncertain.
authors.affiliation: Research Institute for Sport and Exercise Science, Henry Cotton Campus, Liverpool John Moores University, Liverpool, United Kingdom. k.george@livjm.ac.uk
authors.forename: Keith
authors.initials: K
authors.lastname: George
authors.forename: Gregory
authors.initials: G
authors.lastname: Whyte
authors.forename: Claire
authors.initials: C
authors.lastname: Stephenson
authors.forename: Robert
authors.initials: R
authors.lastname: Shave
authors.forename: Ellen
authors.initials: E
authors.lastname: Dawson
authors.forename: Ben
authors.initials: B
authors.lastname: Edwards
authors.forename: David
authors.initials: D
authors.lastname: Gaze
authors.forename: Paul
authors.initials: P
authors.lastname: Collinson
mesh_terms: D000328:Adult; D001831:Body Temperature / Q000502:physiology; D003971:Diastole / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012420:Running / Q000502:physiology*; D013318:Stroke Volume / Q000502:physiology; D020107:Troponin T / Q000097:blood*; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D020107:Troponin T