title: [Therapy for chronic radial epicondylitis with botulinum toxin A].
abstract: OBJECTIVE
  Chronic radial epicondylitis (tennis elbow) is not a serious disease but patients may suffer greatly. If standard conservative and possibly operative treatment modalities have not been effective, patients need further therapy. First trials with injection of Botulinum toxin A (Btx A) have shown promising results. The purpose of the study was to clarify if a single injection of Btx A could be an efficient therapy for chronic radial epicondylitis.
  
  
  METHODS
  In this study 16 patients received injections into the forearm extensors. The site of injection was determined by local tenderness and pain provocation on finger and wrist extension.
  
  
  RESULTS
  A significant clinical improvement was already seen at 2 weeks following injection. The effect was noted up to the last follow-up at 2 years. Continuous and maximal pain during the last 48 h, as self-assessed on a visual analogue scale, was also significantly reduced. In a few cases a significant decrease of muscle strength was seen for the third finger two weeks after injection. It slowly returned thereafter.
  
  
  CONCLUSIONS
  A single injection of Btx A was effective as therapy for chronic tennis elbow. It can be carried out in an out-patient setting, and allows the patient to continue working.
authors.affiliation: Klinik und Poliklinik für Orthopädie, Universitätsklinikum Hamburg-Eppendorf. richard.placzek@charitte.de
authors.forename: R
authors.initials: R
authors.lastname: Placzek
authors.forename: M S
authors.initials: MS
authors.lastname: Lindner
authors.forename: G
authors.initials: G
authors.lastname: Deuretzbacher
authors.forename: A L
authors.initials: AL
authors.lastname: Meiss
mesh_terms: D000553:Ambulatory Care; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D002908:Chronic Disease; D005500:Follow-Up Studies; D018737:Hand Strength; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007273:Injections, Intramuscular; D008279:Magnetic Resonance Imaging; D010147:Pain Measurement; D013716:Tennis Elbow / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D019274:Botulinum Toxins, Type A