The effects of sodium cromoglycate on antigen inhalation challenge in two horses affected with chronic obstructive pulmonary disease (COPD).
80 mg sodium cromoglycate (SCG) was administered by inhalation to two COPD-affected animals known to have respiratory hypersensitivity to Micropolyspora faeni. SCG treatment 20-30 minutes prior to inhalation challenge with M. faeni prevented exacerbation of respiratory disease, usually seen 4-8 hours after challenge. duration of protection against antigen challenge after a single SCG treatment was 4-5 days. The duration of protection was not prolonged by reducing the frequency of antigen challenge. Multiple antigen challenge, using M. faeni and Aspergillus fumigatus, shortened the protective period of SCG to 3 days.
Murphy
J R
JR
Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Great Britain.
McPherson
E A
EA
Lawson
G H
GH
D000280:Administration, Inhalation; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001232:Aspergillus fumigatus / Q000276:immunology; D001985:Bronchial Provocation Tests / Q000662:veterinary; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy* / Q000276:immunology*; D006736:Horses; D008297:Male; D008848:Micromonosporaceae / Q000276:immunology; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000276:immunology / Q000662:veterinary*
D018927:Anti-Asthmatic Agents; D004205:Cromolyn Sodium