title: Prenylated flavonoids as tyrosinase inhibitors.
abstract: In order to find new tyrosinase inhibitors and the effects of prenyl residue on flavonoid molecules, eight prenylated and three synthetic vinylated flavonoids were examined on their inhibitory effect against tyrosinase activity. From the results, kuwanon C, papyriflavonol A, sanggenon D and sophoflavescenol were found to possess the considerable inhibitory activity. Especially, sanggenon D is revealed as a potent inhibitor (IC50 = 7.3 microM), compared to the reference compound, kojic acid (IC50 = 24.8 microM). However, the prenylation with isoprenyl group or the vinylation to flavonoid molecules did not enhance tyrosinase inhibitory activity.
authors.affiliation: College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea.
authors.forename: Nan Kyoung
authors.initials: NK
authors.lastname: Lee
authors.forename: Kun Ho
authors.initials: KH
authors.lastname: Son
authors.forename: Hyeun Wook
authors.initials: HW
authors.lastname: Chang
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Haeil
authors.initials: H
authors.lastname: Park
authors.forename: Moon Young
authors.initials: MY
authors.lastname: Heo
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Kim
mesh_terms: D000363:Agaricales / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D029586:Moraceae / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D017368:Protein Prenylation
chemical_list: D005419:Flavonoids; D010455:Peptides; D010936:Plant Extracts; C117237:sophoflavescenol; D014442:Monophenol Monooxygenase