Putting RNAs in the right place at the right time: RNA localization in the frog oocyte.
Localization of maternal mRNAs in many developing organisms provides the basis for both initial polarity during oogenesis and patterning during embryogenesis. Prominent examples of this phenomenon are found in Xenopus laevis, where localized maternal mRNAs generate developmental polarity along the animal/vegetal axis. Targeting of mRNA molecules to specific subcellular regions is a fundamental mechanism for spatial regulation of gene expression, and considerable progress has been made in defining the underlying molecular pathways.
King
Mary Lou
ML
Department of Cell Biology and Anatomy, University of Miami School of Medicine, 1011 NW 15th St., Miami, FL 33136, USA. mking@med.miami.edu
Messitt
Timothy J
TJ
Mowry
Kimberly L
KL
D000818:Animals; D001692:Biological Transport; D016764:Cell Polarity / Q000502:physiology*; D005260:Female; D009865:Oocytes / Q000378:metabolism / Q000502:physiology*; D014176:Protein Biosynthesis / Q000235:genetics* / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D023121:RNA, Messenger, Stored / Q000235:genetics / Q000378:metabolism; D014982:Xenopus laevis / Q000378:metabolism / Q000502:physiology
D012333:RNA, Messenger; D023121:RNA, Messenger, Stored