[Neurogenesis in the adult brain: the demise of a dogma and the advent of new treatments].
Since the early sixties, many concepts concerning neurogenesis have been progressively ruled out. Proof of the persistence of a physiological neurogenesis in adult mammals, including humans, raised the concept of a unique precursor cell giving birth to neurons and glial cells. According to this concept, a real continuum between neuroepithelial cells, radial glia and astrocytes exists from the embryonic period to adult age and generates both neurons and glial cells. Different factors, either secreted in situ or transported by blood, can influence this physiological neurogenesis process. The targets and role of newborn neurons are not clearly understood. In pathological conditions (ischemia, epilepsy, lesions), the physiological neurogenesis process is enhanced; however the significance of this neurogenesis excess (beneficial or deleterious) is not completely known. Advances in understanding the regulation of neurogenesis in these different conditions represent hopes of new therapeutic procedures, not only by improving the control of differentiation and survival of transplanted stem cells, but also by the possibility of modifying the processes of "endogenous neurogenesis".
Crespel
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Service Explorations Neurologiques et Epileptologie, Hôpital Gui de Chauliac, Montpellier. a-crespel@chu-montpellier.fr
Baldy-Moulinier
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Lerner Natoli
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M
D000328:Adult; D000367:Age Factors; D000818:Animals; D001921:Brain / Q000166:cytology / Q000254:growth & development*; D006801:Humans; D009024:Morphogenesis; D019636:Neurodegenerative Diseases / Q000601:surgery; D033581:Stem Cell Transplantation; D013234:Stem Cells