Ibuprofen and cerebral oxygenation and circulation.
The effect of prophylactic administration of ibuprofen on the cerebral circulation in preterm babies was measured with near infrared spectroscopy. No significant difference in the change in cerebral blood volume, change in cerebral blood flow, or tissue oxygenation index was found between administration of ibuprofen or placebo.
Naulaers
G
G
Neonatal Intensive Care Unit, Department of Paediatrics, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium. gunnar.naulaers@uz.kuleuven.ac.be
Delanghe
G
G
Allegaert
K
K
Debeer
A
A
Cossey
V
V
Vanhole
C
C
Casaer
P
P
Devlieger
H
H
Van Overmeire
B
B
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004311:Double-Blind Method; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects*; D011446:Prospective Studies; D019265:Spectroscopy, Near-Infrared
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010100:Oxygen; D007052:Ibuprofen