title: Implications for the human food chain of models of cadmium accumulation in sheep.
abstract: Critical limits for cadmium in parts of the human food chain are considered to have too small margins of safety and some limits are regularly exceeded. There is concern about the exposure of some sections of the population to cadmium in the human food chain, in particular regarding offal, which is a major source of cadmium to some sectors. The kidney is the first organ of sheep to reach the limit of fitness for human consumption. A model (based on a meta-analysis) predicts that this would occur after a mean of just 130 days of feeding sheep the maximum permitted cadmium concentration in feed (in the European Union) in the organic form. Thus it is not surprising that sheep organs are found routinely to exceed cadmium limits. Since reduction of maximum cadmium levels in sheep feed or of the duration of their exposure are not economically viable measures of control, routine removal of liver and kidney from older sheep from the food chain is recommended as the best option to reduce human dietary cadmium intake from sheep origin.
authors.affiliation: Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
authors.forename: S H
authors.initials: SH
authors.lastname: Prankel
authors.forename: R M
authors.initials: RM
authors.lastname: Nixon
authors.forename: C J C
authors.initials: CJ
authors.lastname: Phillips
mesh_terms: D000821:Animal Feed; D000818:Animals; D002104:Cadmium / Q000032:analysis*; D004785:Environmental Pollutants / Q000032:analysis*; D020387:Food Chain; D005506:Food Contamination; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008460:Meat / Q000032:analysis*; D008954:Models, Biological; D012756:Sheep
chemical_list: D004785:Environmental Pollutants; D002104:Cadmium