Severe systemic autoimmune disease associated with Epstein-Barr virus infection.
Infection with Epstein-Barr virus (EBV) has been associated with different autoimmune manifestations. The authors describe a girl who developed a severe systemic autoimmune disease with severe autoimmune hemolytic anemia, mild autoimmune thrombopenia, antineutrophil antibodies, and fatal autoimmune hepatitis after EBV infection. Despite immunosuppressive treatment and ultimately liver transplantation, this patient could not overcome her clinical condition and died. The etiopathogenesis of this complex disease and the association with EBV infection is discussed.
Sevilla
Julián
J
Pediatric Oncohematology, Hospital Niño Jesús, Menéndez Pelayo 65, Madrid 28009, Spain. jsevilla.hnjs@salud.madrid.org
del Carmen Escudero
Maria
M
Jiménez
Raquel
R
González-Vicent
Marta
M
Manzanares
Javier
J
García-Novo
Dolores
D
Madero
Luis
L
D000743:Anemia, Hemolytic / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D000974:Antibodies, Antinuclear; D001327:Autoimmune Diseases / Q000209:etiology* / Q000473:pathology; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006505:Hepatitis / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D016031:Liver Transplantation; D013921:Thrombocytopenia / Q000209:etiology
D000974:Antibodies, Antinuclear; D007166:Immunosuppressive Agents