title: Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa.
abstract: To study the role of adipose tissue-derived hormones in the pathophysiology of eating disorders, circulating levels of adiponectin, resistin, and other hormonal and metabolic parameters were measured in 16 females with the restrictive subtype of anorexia nervosa (R-AN), 10 females with the binge/purge subtype of anorexia nervosa (P-AN), 15 females with bulimia nervosa (BN), and 12 age-matched healthy females (C). Body mass index (BMI), body fat content, and serum leptin levels were severely decreased in R-AN and moderately decreased in P-AN patients, whereas the BN group did not differ from C in these parameters. Serum soluble leptin receptor levels were increased in R-AN and P-AN and unchanged in BN patients. Circulating adiponectin levels were inversely related to BMI and were unchanged in BN patients and increased by 53% in P-AN and by 96% in R-AN relative to C group, respectively. In contrast, resistin levels in malnourished R-AN and P-AN were not different from either C or BN groups and showed no significant relationship to BMI or body fat content. We suggest that increased adiponectin levels reflect decreased body fat content in AN patients. In contrast, circulating resistin levels do not appear to be closely related to the nutritional status.
authors.affiliation: Third Department of Medicine, First Faculty of Medicine, Charles University, U Nemocnice 1, 128 08, Prague 2, Czech Republic. mhalu@lf1.cuni.cz
authors.forename: Jitka
authors.initials: J
authors.lastname: Housova
authors.forename: Katerina
authors.initials: K
authors.lastname: Anderlova
authors.forename: Jarmila
authors.initials: J
authors.lastname: Krizová
authors.forename: Denisa
authors.initials: D
authors.lastname: Haluzikova
authors.forename: Jaromir
authors.initials: J
authors.lastname: Kremen
authors.forename: Tereza
authors.initials: T
authors.lastname: Kumstyrová
authors.forename: Hana
authors.initials: H
authors.lastname: Papezová
authors.forename: Martin
authors.initials: M
authors.lastname: Haluzik
mesh_terms: D052242:Adiponectin; D000273:Adipose Tissue / Q000378:metabolism; D000856:Anorexia Nervosa / Q000145:classification / Q000378:metabolism*; D001786:Blood Glucose; D015992:Body Mass Index; D002032:Bulimia / Q000378:metabolism*; D005260:Female; D006706:Homeostasis; D006729:Hormones, Ectopic / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D020738:Leptin / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D054411:Receptors, Leptin; D052243:Resistin
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D006729:Hormones, Ectopic; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; C499624:RETN protein, human; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D052243:Resistin