Interleukin-17/interleukin-17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection.
We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R(-/-) mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.
Kelly
Michelle N
MN
Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Kolls
Jay K
JK
Happel
Kyle
K
Schwartzman
Joseph D
JD
Schwarzenberger
Paul
P
Combe
Crescent
C
Moretto
Magali
M
Khan
Imtiaz A
IA
D000818:Animals; D002465:Cell Movement; D005260:Female; D020381:Interleukin-17 / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000276:immunology*; D010529:Peritoneal Cavity / Q000166:cytology; D018123:Receptors, Interleukin / Q000502:physiology*; D053722:Receptors, Interleukin-17; D015398:Signal Transduction; D014124:Toxoplasmosis, Animal / Q000276:immunology*
C491673:Il17ra protein, mouse; D020381:Interleukin-17; D018123:Receptors, Interleukin; D053722:Receptors, Interleukin-17