title: Ruthenium- and enzyme-catalyzed dynamic kinetic asymmetric transformation of 1,4-diols: synthesis of gamma-hydroxy ketones.
abstract: Enzymatic kinetic resolution of unsymmetrical 1,4-diols in combination with a ruthenium-catalyzed hydrogen transfer process led to a dynamic kinetic asymmetric transformation (DYKAT) of the least hindered alcohol. Oxidation of the second hydroxy group takes place under the reaction conditions leading to the formation of gamma-acetoxy ketones in high enantiomeric purity.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
authors.forename: Belén
authors.initials: B
authors.lastname: Martín-Matute
authors.forename: Jan-E
authors.initials: JE
authors.lastname: Bäckvall
mesh_terms: D002384:Catalysis; D004798:Enzymes / Q000378:metabolism*; D007659:Ketones / Q000138:chemical synthesis*; D007700:Kinetics; D008958:Models, Molecular; D013057:Spectrum Analysis; D013237:Stereoisomerism
chemical_list: D004798:Enzymes; D007659:Ketones