Production of chemokines in Kawasaki disease, Henoch-Schönlein purpura and acute febrile illness.
We compared the production of three chemokines; interferon-gamma-inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and growth-related onco-gene-alpha(Gro-alpha) that attracts monocytes or neutrophils, or both, in peripheral blood at acute stage of Kawasaki disease (n=29), Henoch-Schönlein purpura (n=15) and acute febrile illnesses (n=12). The production of the chemokines was assayed by ELISA. The plasma levels of IP-10 were markedly elevated in Kawasaki disease (538.6+/-336.4 pg/mL) and acute febrile illnesses (417.1 +/-262.2 pg/mL) compared with in Henoch-Schönlein purpura (58.7 +/-95.7 pg/mL) (p<0.05). The MCP-1 levels were elevated in Kawasaki disease (443.0 +/-473.1 pg/mL) and acute febrile illnesses (328.6 +/-261.1 pg/mL) compared with in Henoch-Schönlein purpura (82.9 +/-79.0 pg/mL) (p<0.05). The Gro-alpha levels were elevated only in acute febrile illnesses (134.3 +/-153.6 pg/mL) compared with in Kawasaki disease (31.8 +/-22.1 pg/mL) or Henoch-Schönlein purpura (29.4 +/-53.3 pg/mL) (p<0.05). According to these results, monocytes may play an important role in Kawasaki disease. In acute febrile illnesses, both monocytes and neutrophils may play an important role. By contrast, Henoch-Schönlein purpura may not be associated with the role of monocytes and neutrophils. Further studies using a larger number of cases are needed.
Chung
Hyo Seok
HS
Department of Pediatrics, Yeungnam University, College of Medicine, Daegu, Korea.
Kim
Hyo Young
HY
Kim
Hee Sun
HS
Lee
Hee Jung
HJ
Yuh
Ji Hyun
JH
Lee
Eun Sil
ES
Choi
Kwang Hae
KH
Lee
Young Hwan
YH
D000208:Acute Disease; D000293:Adolescent; D018925:Chemokines / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood* / Q000453:epidemiology*; D007231:Infant, Newborn; D007723:Korea / Q000453:epidemiology; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000453:epidemiology*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
D018925:Chemokines