title: NXY-059: a neuroprotective agent in acute stroke.
abstract: Free radicals play an important role in secondary processes in ischaemic brain injury. Disodium 4-[(tert-butylimino) methyl] benzene-1,3-disulphonate N-oxide (NXY-059) is a nitrone-based free radical trapping agent. Findings from animal stroke models showed that NXY-059 is a potent neuroprotective agent that has a large window of therapeutic opportunity and long-lasting effects. Therefore, NXY-059 may be used as a monotherapy agent for treatment of acute stroke. NXY-059 may also be used as an adjunct agent to thrombolytic therapy, as it can reduce tissue plasminogen activator-induced haemorrhage in ischaemic stroke.
authors.affiliation: Stroke Research Laboratory, University of Alberta, Edmonton, Canada.
authors.forename: C X
authors.initials: CX
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Shuaib
mesh_terms: D000818:Animals; D001557:Benzenesulfonates; D005609:Free Radicals; D006801:Humans; D008297:Male; D009589:Nitrogen Oxides / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D020521:Stroke / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D001557:Benzenesulfonates; D005609:Free Radicals; D009589:Nitrogen Oxides; C120851:disufenton sodium