A 1-year study on carbon, titanium surface-modified intraocular lens in rabbit eyes.
OBJECTIVE
To evaluate biocompatibility of Carbon (C) and Titanum (T) surface modified Polymethyl-methacrylate (PMMA) Intraocular Lens (IOLs) in pseudophakic rabbit model.


METHODS
Extracapsule Cataract Extraction (ECCE) and IOLs implantation were performed in Japanese albino rabbit eyes. The white cell concentration from the aqueous humor in the eyes was counted within 3 months post operation. The inflammatory cells in the eyes were noted and graded by slit lamp using a semiquantitive scale up to 1-year post operation. The rabbit eyes were inspected under light microscopy, where pathology of the eyes was caracterized.


RESULTS
The white cell concentration in the aqueous humor was significantly attenuated in C and T IOL-implanted eyes compared with PMMA IOL-implanted eyes 1 week post operation. The exudate levels in the anterior ocular chamber and the posterior synechias were significant lower in T IOL-implanted eyes than in PMMA IOL-implanted eyes 1 week and 2 weeks after surgery. The exudate levels in the anterior chambers and the posterior synechias were not significantly different in C IOL-implanted versus PMMA IOL-implanted eyes.


CONCLUSIONS
This in vivo study provides evidence of effectiveness of Carbon and Titanium IOLs in improving the biocompatibility of PMMA IOLs.
Yuan
Zhaoxu
Z
Scott & White Hospital, 702 SW H.K. Dodgen Loop, Temple, TX 76504, USA. yuanzhaoxu3@yahoo.com
Sun
Huimin
H
Yuan
Jiaqin
J
D000818:Animals; D001082:Aqueous Humor / Q000166:cytology; D002244:Carbon; D020099:Coated Materials, Biocompatible; D005260:Female; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology; D008297:Male; D008422:Materials Testing; D019904:Polymethyl Methacrylate; D011817:Rabbits; D014025:Titanium
D020099:Coated Materials, Biocompatible; D002244:Carbon; D019904:Polymethyl Methacrylate; D014025:Titanium