Concise synthesis of novel practical sulfamide-amine alcohols for the enantioselective addition of diethylzinc to aldehydes.
Novel sulfamide-amine alcohol ligands were designed using a grafting strategy and synthesized from readily available starting materials via a simple, efficient method. The key features of these ligands for the asymmetric addition of diethylzinc to aldehydes included stability, enhanced effectiveness without using Ti(O(i)Pr)(4), suitability for a variety of aldehydes, the ability to operate at room temperature, and selectability to afford either absolute configuration products with enantiomeric excess up to >99%.
Mao
Jincheng
J
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Wan
Boshun
B
Wang
Rongliang
R
Wu
Fan
F
Lu
Shiwei
S