title: Cortical effects of quetiapine in first-episode schizophrenia: a preliminary functional magnetic resonance imaging study.
abstract: BACKGROUND
  Quetiapine improves both psychotic symptoms and cognitive function in schizophrenia. The neural basis of these actions is poorly understood.
  
  
  METHODS
  Three subject groups underwent a single functional magnetic resonance imaging (fMRI) session: drug-naive (n = 7) and quetiapine-treated samples of patients with schizophrenia (n = 8) and a healthy control group (n = 8). The fMRI session included an overt verbal fluency task and a passive auditory stimulation task.
  
  
  RESULTS
  In the verbal fluency task, there was significantly increased activation in the left inferior frontal cortex in the quetiapine-treated patients and the healthy control sample compared with the drug-naive sample. During auditory stimulation, the healthy control group and stably treated group produced significantly greater activation in the superior temporal gyrus than the drug-naive sample.
  
  
  CONCLUSIONS
  Quetiapine treatment is associated with altered blood oxygen level-dependent responses in both the prefrontal and temporal cortex that cannot be accounted for by improved task performance subsequent to drug treatment.
authors.affiliation: Section of Neurochemical Imaging, Institute of Psychiatry, Kings College London, 1 Windsor Walk, London SE5 8AF, United Kingdom. hugh.jones@iop.kcl.ac.uk
authors.forename: Hugh M
authors.initials: HM
authors.lastname: Jones
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Brammer
authors.forename: Mary
authors.initials: M
authors.lastname: O'Toole
authors.forename: Tess
authors.initials: T
authors.lastname: Taylor
authors.forename: Ruth I
authors.initials: RI
authors.lastname: Ohlsen
authors.forename: Richard G
authors.initials: RG
authors.lastname: Brown
authors.forename: Richard
authors.initials: R
authors.lastname: Purvis
authors.forename: Steven
authors.initials: S
authors.lastname: Williams
authors.forename: Lyn S
authors.initials: LS
authors.lastname: Pilowsky
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001931:Brain Mapping; D000077463:Carbamide Peroxide; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D003071:Cognition / Q000187:drug effects; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010545:Peroxides / Q000097:blood; D000069348:Quetiapine Fumarate; D011930:Reaction Time / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology*; D014508:Urea / Q000031:analogs & derivatives* / Q000097:blood; D014706:Verbal Learning / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D004338:Drug Combinations; D010545:Peroxides; D000069348:Quetiapine Fumarate; D000077463:Carbamide Peroxide; D014508:Urea