title: Mitochondrial proteomics in free radical research.
abstract: The importance of mitochondrial dysfunction in numerous diseases has long been appreciated. The impact of oxidative and nitrosative stress on mitochondrial function is complex; however, recent progress in the field using proteomics technologies has begun to shed light on the molecular defects responsible for mitochondrial and cellular dysfunction. This review focuses on the state-of-the-art technologies being used and current research endeavors in the field of mitochondrial proteomics with emphasis on those advancements being made in the field of free radical biology to identify the importance of alterations to the mitochondrial proteome in the development of disease.
authors.affiliation: Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, 1530 3rd Avenue South, Ryals Building, Room 623, Birmingham, AL 35294, USA. sbailey@uab.edu
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Bailey
authors.forename: Aimee
authors.initials: A
authors.lastname: Landar
authors.forename: Victor
authors.initials: V
authors.lastname: Darley-Usmar
mesh_terms: D000438:Alcohols; D000818:Animals; D003545:Cysteine / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D009584:Nitrogen / Q000378:metabolism; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D020543:Proteome; D040901:Proteomics; D014443:Tyrosine / Q000378:metabolism
chemical_list: D000438:Alcohols; D005609:Free Radicals; D020543:Proteome; D014443:Tyrosine; D003545:Cysteine; D009584:Nitrogen; D010100:Oxygen