title: Late coronary artery recanalization effects on left ventricular remodelling and contractility by magnetic resonance imaging.
abstract: OBJECTIVE
  To assess the recanalization effects of post-myocardial infarction (MI) on left ventricular (LV) remodelling and contractility in relation to conservative therapy.
  
  
  RESULTS
  Thirty-six patients with occluded infarct-related artery between 12 h and 14 days post-anterior MI were randomized to percutaneous coronary intervention (PCI group) or conservative therapy (no-PCI group). Magnetic resonance imaging was performed at enrollment and after 6 months. The left ventricle was divided into infarct, adjacent, and remote segments. There was no difference in relation to LV volume between groups at the 6 month follow-up. Change in LV ejection fraction was favourable to the PCI group: 5.00% vs. -0.76%, P=0.012. Change in circumferential shortening (Ecc) of the remote segments in the PCI group was significantly better than in the no-PCI group: -1.67+/-6.30% vs. 0.29+/-6.02%, P<0.001. Infarct size and LV mass were similar between groups.
  
  
  CONCLUSIONS
  Late recanalization improved LV ejection fraction and myocardial contractility in late follow-up, but did not change the ventricular volumes. Improvement in the left ventricle global and regional contractility may benefit the long-term outcome in post-MI patients with sustained patency of the infarct-related artery.
authors.affiliation: Acute Coronary Disease Unit, Heart Institute (InCor), University of São Paulo Medical School, Av. Enéas de Carvalho de Aguiar, 44, 2nd Floor, 05403-000, São Paulo, Brazil. joaoclima@uol.com.br
authors.forename: João C
authors.initials: JC
authors.lastname: Silva
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Rochitte
authors.forename: José S
authors.initials: JS
authors.lastname: Júnior
authors.forename: Jeanne
authors.initials: J
authors.lastname: Tsutsui
authors.forename: Joalbo
authors.initials: J
authors.lastname: Andrade
authors.forename: Eulógio E
authors.initials: EE
authors.lastname: Martinez
authors.forename: Paulo J
authors.initials: PJ
authors.lastname: Moffa
authors.forename: José C
authors.initials: JC
authors.lastname: Menegheti
authors.forename: Roberto
authors.initials: R
authors.lastname: Kalil-Filho
authors.forename: José F
authors.initials: JF
authors.lastname: Ramires
authors.forename: José C
authors.initials: JC
authors.lastname: Nicolau
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D009203:Myocardial Infarction / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D020257:Ventricular Remodeling / Q000502:physiology*