[Bone mineral metabolism: recent data and perspectives related to osteogenesis].
Important data have recently been added to our knowledge of bone mineral metabolism in children. Molecular pathophysiology of several pediatric syndromes has been clarified. Specially, the components of endocrine and metabolic regulations are tightly related with regard to the trophicity of bone. On another hand, the impact of several therapeutics of bone diseases like biphosphonates, parathormone (PTH) or growth hormone on bone anabolism is now strongly emphasized. All these points are important for the becoming of bone pediatric diseases in the adult life. Here we analyze the essential components of mineral metabolism and of its regulation in view of the recent biological data, like PTH/PTHrP (PTH-related peptide)-evoked cell signaling, the role of FGF 23 (Fibroblast growth factor 23) in hypophosphatemia and the regulation of vitamin D metabolism by 1alpha-hydroxylase. Inter-relation of these regulating elements is present in several genetic diseases and in the Mc Cune Albright syndrome. Relationships between metabolic and endocrine factors are analyzed considering their impact on PTH secretion and osteogenesis.
Gennero
I
I
Laboratoire de biochimie, hôpital La Grave, TSA 60033, 31059 Toulouse 9, France.
Moulin
P
P
Edouard
T
T
Conte-Auriol
F
F
Tauber
M T
MT
Salles
J P
JP
D001847:Bone Diseases / Q000503:physiopathology; D001842:Bone and Bones / Q000378:metabolism*; D002648:Child; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D010012:Osteogenesis / Q000502:physiology*; D044162:Parathyroid Hormone-Related Protein / Q000502:physiology
C000717427:FGF23 protein, human; D044162:Parathyroid Hormone-Related Protein; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23