Analgesic and anti-inflammatory activities of [6]-gingerol.
In the present study, the analgesic and anti-inflammatory effects of [6]-gingerol, which is the pungent constituent of ginger, were performed. Intraperitoneal administration of [6]-gingerol (25 mg/kg-50 mg/kg) produced an inhibition of acetic acid-induced writhing response and formalin-induced licking time in the late phase. [6]-Gingerol (50 mg/kg-100 mg/kg) also produced an inhibition of paw edema induced by carrageenin. These results suggested that [6]-gingerol possessed analgesic and anti-inflammatory activities.
Young
Haw-Yaw
HY
TzuHui Institute of Technology, 926 Ping'Tung, Taiwan, ROC.
Luo
Yen-Lin
YL
Cheng
Hao-Yuan
HY
Hsieh
Wen-Chiuan
WC
Liao
Jung-Chun
JC
Peng
Wen-Huang
WH
D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan; D002396:Catechols; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005233:Fatty Alcohols / Q000494:pharmacology*; D005557:Formaldehyde; D020939:Zingiber officinale; D006614:Hindlimb; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D008517:Phytotherapy; D013997:Time Factors
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D002396:Catechols; D005233:Fatty Alcohols; D005557:Formaldehyde; D002351:Carrageenan; C007845:gingerol; D019342:Acetic Acid