DG-CST (Disease Gene Conserved Sequence Tags), a database of human-mouse conserved elements associated to disease genes.
The identification and study of evolutionarily conserved genomic sequences that surround disease-related genes is a valuable tool to gain insight into the functional role of these genes and to better elucidate the pathogenetic mechanisms of disease. We created the DG-CST (Disease Gene Conserved Sequence Tags) database for the identification and detailed annotation of human-mouse conserved genomic sequences that are localized within or in the vicinity of human disease-related genes. CSTs are defined as sequences that show at least 70% identity between human and mouse over a length of at least 100 bp. The database contains CST data relative to over 1088 genes responsible for monogenetic human genetic diseases or involved in the susceptibility to multifactorial/polygenic diseases. DG-CST is accessible via the internet at http://dgcst.ceinge.unina.it/ and may be searched using both simple and complex queries. A graphic browser allows direct visualization of the CSTs and related annotations within the context of the relative gene and its transcripts.
Boccia
Angelo
A
CEINGE Biotecnologie Avanzate, Naples, Italy.
Petrillo
Mauro
M
di Bernardo
Diego
D
Guffanti
Alessandro
A
Mignone
Flavio
F
Confalonieri
Stefano
S
Luzi
Lucilla
L
Pesole
Graziano
G
Paolella
Giovanni
G
Ballabio
Andrea
A
Banfi
Sandro
S
D000818:Animals; D001483:Base Sequence; D003196:Computer Graphics; D017124:Conserved Sequence; D030561:Databases, Nucleic Acid; D020022:Genetic Predisposition to Disease; D023281:Genomics; D006801:Humans; D051379:Mice; D014584:User-Computer Interface