title: Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton.
abstract: Classical cadherin adhesion molecules are fundamental determinants of tissue organization in both health and disease. Recent advances in understanding the molecular and cellular basis of cadherin function have revealed that these adhesion molecules serve as molecular couplers, linking cell surface adhesion and recognition to both the actin cytoskeleton and cell signalling pathways. We will review some of these developments, to provide an overview of progress in this rapidly-developing area of cell and developmental biology.
authors.affiliation: Division of Molecular Cell Biology, Institute for Molecular Bioscience; School for Biomedical Science, The University of Queensland, St. Lucia, Australia 4072.
authors.forename: Marita
authors.initials: M
authors.lastname: Goodwin
authors.forename: Alpha S
authors.initials: AS
authors.lastname: Yap
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D046912:Multiprotein Complexes; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000199:Actins; D015820:Cadherins; D003598:Cytoskeletal Proteins; D046912:Multiprotein Complexes