title: cDNA microarray gene expression analysis and toxicological phenotype for anticancer drug.
abstract: Toxicogenomics, the subdiscipline that merges genomics with toxicology, hold the promise to contributing toward the goal of elucidating mechanism by studying genomic profiling related with various drugs. The application of gene expression profiling technology to examine multiple genes and signaling pathways promises a significant advance in understanding the toxic mechanisms of various drugs and prediction of new drug candidate. Toxicogenomics is emerging field combining genomics and bioinformatics to identify and characterize mechanisms of toxicity of drug and various compounds. The principal hypothesis underlying on this field is that chemical-specific pattern of altered gene expression is related with each chemicals properties, especially toxicological property, and it will be revealed using high-density microarray analysis of sample from exposed organisms. So, in this study we compare the gene expression pattern of two anticancer drugs paclitaxel and orally absorbable paclitaxel, using the cDNA microarray. And from the result of this study, it is possible to provide the new possibility for genome-wide insight into mechanism of their anticancer activity and toxicological phenotype.
authors.affiliation: Research Institute, Shin-Won Scientific Co., Ltd. Gyeonggi-do, South Korea.
authors.forename: Gyoung-Jae
authors.initials: GJ
authors.lastname: Lee
authors.forename: Wan-Seon
authors.initials: WS
authors.lastname: Lee
authors.forename: Ki-Seon
authors.initials: KS
authors.lastname: Jeon
authors.forename: Chan-Hwi
authors.initials: CH
authors.lastname: Um
authors.forename: Yang-Suk
authors.initials: YS
authors.lastname: Kim
authors.forename: Seung-Jun
authors.initials: SJ
authors.lastname: Kim
authors.forename: Chang-Hyeon
authors.initials: CH
authors.lastname: Lee
authors.forename: Hyun-Kyu
authors.initials: HK
authors.lastname: Yoon
authors.forename: Seung Yong
authors.initials: SY
authors.lastname: Hwang
authors.forename: Joon-Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Jae-Woong
authors.initials: JW
authors.lastname: Hwang
authors.forename: Kyung-Sun
authors.initials: KS
authors.lastname: Kang
authors.forename: Yong-Soon
authors.initials: YS
authors.lastname: Lee
authors.forename: Maeng-Sup
authors.initials: MS
authors.lastname: Kim
authors.forename: Kum-Jin
authors.initials: KJ
authors.lastname: Chon
authors.forename: Chan-Dong
authors.initials: CD
authors.lastname: Yeo
authors.forename: Jong-Soo
authors.initials: JS
authors.lastname: Kang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D017239:Paclitaxel / Q000008:administration & dosage / Q000633:toxicity*; D010641:Phenotype; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D043922:Toxicogenetics
chemical_list: D000970:Antineoplastic Agents; D017239:Paclitaxel