Controlled release of proteins from degradable poly(ether-ester) multiblock copolymers.
A new series of multiblock poly(ether-ester)s based on poly(ethylene glycol) (PEG), butylene terephthalate (BT) and butylene succinate (BS) segments were introduced as matrices for controlled release applications. The release of two model proteins, lysozyme and bovine serum albumin (BSA), from poly(ether-ester) films were evaluated and correlated to the swelling and degradation characteristics of the polymer matrices. First- and zero-order profiles were found for the release of lysozyme, depending on the composition of the polymer matrix. The initial diffusion coefficient was correlated to the swelling of the matrix, which increased with longer PEG segments and lower BT/BS ratios of the polymer. High swelling matrices released the lysozyme according to diffusion-controlled first-order release profiles. Zero-order release profiles were obtained from less swollen matrices due to a combination of diffusion and degradation of the matrix. In contrast to the release of lysozyme, BSA was released from the poly(ether-ester) matrices via delayed release profiles. Both the delay time and the release rate could be tailored by varying the matrix composition. The BSA release rate was mainly determined by the degradation, whereas the delay time was determined by a combination of the swelling and the degradation rate of the polymer matrix.
van Dijkhuizen-Radersma
R
R
OctoPlus Technologies B.V., Zernikedreef 12, 2333 CL Leiden, The Netherlands. vandijkhuizen@octoplus.nl
Métairie
S
S
Roosma
J R
JR
de Groot
K
K
Bezemer
J M
JM
D004058:Diffusion; D016503:Drug Delivery Systems; D009113:Muramidase / Q000008:administration & dosage / Q000737:chemistry; D011091:Polyesters / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000008:administration & dosage; D011506:Proteins / Q000008:administration & dosage*; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility
D011091:Polyesters; D011506:Proteins; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D009113:Muramidase