Selectivity for the spatial and nonspatial attributes of auditory stimuli in the ventrolateral prefrontal cortex.
Spatial and nonspatial auditory processing is hypothesized to occur in parallel dorsal and ventral pathways, respectively. In this study, we tested the spatial and nonspatial sensitivity of auditory neurons in the ventrolateral prefrontal cortex (vPFC), a cortical area in the hypothetical nonspatial pathway. We found that vPFC neurons were modulated significantly by both the spatial and nonspatial attributes of an auditory stimulus. When comparing these responses with those in anterolateral belt region of the auditory cortex, which is hypothesized to be specialized for processing the nonspatial attributes of auditory stimuli, we found that the nonspatial sensitivity of vPFC neurons was poorer, whereas the spatial selectivity was better than anterolateral neurons. Also, the spatial and nonspatial sensitivity of vPFC neurons was comparable with that seen in the lateral intraparietal area, a cortical area that is a part of the dorsal pathway. These data suggest that substantial spatial and nonspatial processing occurs in both the dorsal and ventral pathways.
Cohen
Yale E
YE
Department of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA. yec@dartmouth.edu
Russ
Brian E
BE
Gifford
Gordon W
GW
Kiringoda
Ruwan
R
MacLean
Katherine A
KA
D000200:Action Potentials / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology; D001306:Auditory Pathways / Q000033:anatomy & histology / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D005260:Female; D005403:Fixation, Ocular / Q000502:physiology; D008253:Macaca mulatta; D009474:Neurons / Q000502:physiology; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology*; D012438:Saccades / Q000502:physiology; D013017:Sound Localization / Q000502:physiology; D013045:Species Specificity; D014828:Vocalization, Animal