title: Clinical management of osteogenesis imperfecta.
abstract: Knowledge of the natural history of different types of OI permits planning of rehabilitation goals for children with OI. Notwithstanding this knowledge, rehabilitation will need to be modified to accommodate unexpected fractures and the highly variable chance of deformity in each individual. Immobilisation should be minimized to avoid immobilization osteoporosis. New rehabilitation issues include basilar impression, recommencement of fractures in postmenopausal women with OI, pregnancy related bone loss and sleep apnoea.
authors.affiliation: Department of Genetics, The Children's Hospital, Camperdown NSW 2050, Australia.
authors.forename: D O
authors.initials: DO
authors.lastname: Sillence
authors.forename: K
authors.initials: K
authors.lastname: Morley
authors.forename: J E
authors.initials: JE
authors.lastname: Ault
mesh_terms: D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D024042:Collagen Type I / Q000172:deficiency* / Q000235:genetics; D050723:Fractures, Bone / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009154:Mutation / Q000235:genetics; D010013:Osteogenesis Imperfecta / Q000473:pathology / Q000503:physiopathology* / Q000534:rehabilitation*; D010806:Physical Education and Training / Q000592:standards; D026741:Physical Therapy Modalities / Q000592:standards
chemical_list: D024042:Collagen Type I