Direct estimation of genetic principal components: simplified analysis of complex phenotypes.
Estimating the genetic and environmental variances for multivariate and function-valued phenotypes poses problems for estimation and interpretation. Even when the phenotype of interest has a large number of dimensions, most variation is typically associated with a small number of principal components (eigen-vectors or eigenfunctions). We propose an approach that directly estimates these leading principal components; these then give estimates for the covariance matrices (or functions). Direct estimation of the principal components reduces the number of parameters to be estimated, uses the data efficiently, and provides the basis for new estimation algorithms. We develop these concepts for both multivariate and function-valued phenotypes and illustrate their application in the restricted maximum-likelihood framework.
Kirkpatrick
Mark
M
Section of Integrative Biology, University of Texas, Austin, Texas 78712, USA. kirkp@mail.utexas.edu <kirkp@mail.utexas.edu>
Meyer
Karin
K
D000465:Algorithms; D003627:Data Interpretation, Statistical; D014644:Genetic Variation; D010641:Phenotype; D025341:Principal Component Analysis