Monoamine oxidase inhibitors from Gentiana lutea.
Three monoamine oxidase (MAO) inhibitors were isolated from Gentiana lutea. Their structures were elucidated to be 3-3''linked-(2'-hydroxy-4-O-isoprenylchalcone)-(2'''-hydroxy-4''-O-isoprenyldihydrochalcone) (1), 2-methoxy-3-(1,1'-dimethylallyl)-6a,10a-dihydrobenzo(1,2-c)chroman-6-one and 5-hydroxyflavanone. These compounds, and the hydrolysis product of 1, displayed competitive inhibitory properties against MAO-B which was more effective than MAO-A.
Haraguchi
Hiroyuki
H
Faculty of Life Science and Biotechnology, Fukuyama University, Gakuen-cho, Fukuyama 729-0292, Japan. haragu@bt.fubt.fukuyama-u.ac.jp
Tanaka
Yasumasa
Y
Kabbash
Amal
A
Fujioka
Toshihiro
T
Ishizu
Takashi
T
Yagi
Akira
A
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D030012:Gentiana / Q000737:chemistry*; D066298:In Vitro Techniques; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry; D011208:Powders; D051381:Rats; D017208:Rats, Wistar
D008996:Monoamine Oxidase Inhibitors; D010936:Plant Extracts; D011208:Powders; D008995:Monoamine Oxidase