title: Antifungal properties of pristimerin and celastrol isolated from Celastrus hypoleucus.
abstract: Pristimerin and celastrol isolated from the roots of Celastrus hypoleucus (Oliv) Warb f argutior Loes exhibited inhibitory effects against diverse phytopathogenic fungi. Pristimerin and celastrol were found to inhibit the mycelial growth of Rhizoctonia solani Kuhn and Glomerella cingulata (Stonem) Spauld & Schrenk in vitro by 83.6 and 62.6%, respectively, at 10 microg ml(-1). Pristimerin showed good preventive effect (96.7% at 100 microg ml(-1)) and curative effect (66.5% at 100 microg ml(-1)) against wheat powdery mildew in vivo. For celastrol, the preventive and curative effects against wheat powdery mildew were 80.5 and 45.4%, respectively, at 100 microg ml(-1).
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
authors.forename: Du-Qiang
authors.initials: DQ
authors.lastname: Luo
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Xuan
authors.initials: X
authors.lastname: Tian
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Shao
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D031247:Celastrus / Q000737:chemistry*; D005659:Fungicides, Industrial / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D005659:Fungicides, Industrial; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C050414:celastrol