title: [Expression of uncoupling protein 2 in periimplantation endometrium and its relationship with infertility].
abstract: OBJECTIVE
  To study the expression of uncoupling protein 2 (UCP2) mRNA and protein in the endometrium and its changes during periimplantation period in relation to infertility.
  
  
  METHODS
  In situ hybridation and Western blotting were used to detect 21 endometrium specimens from normal cycling women during different menstrual phases, 22 secretory endometrium specimens from infertile women and 7 decidual and chorionic villus specimens.
  
  
  RESULTS
  UCP2 mRNA and protein were detected in the endometrium and decidua besides, the trophoblast, and UCP2 level in the endometrium increased during pregnancy. Compared with normal women, women with hydrosalpinges had significantly stronger endometrial UCP2 expression in the mid-luteal stage.
  
  
  CONCLUSIONS
  UCP2 down-regulates reactive oxygen species and plays a role in the regulation of inflammatory events to prepare for embryo implantation. Strong endometrial UCP2 expression might be an important reason that hydrosalpinges affect embryo implantation.
authors.affiliation: Assisted Reproductive Technology Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. fzhlxy@fimmu.com
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Fu
authors.forename: Shi-ling
authors.initials: SL
authors.lastname: Chen
authors.forename: Ling-hong
authors.initials: LH
authors.lastname: Kong
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Si-mei
authors.initials: SM
authors.lastname: Chen
authors.forename: Fu-qi
authors.initials: FQ
authors.lastname: Xing
mesh_terms: D000328:Adult; D003656:Decidua / Q000378:metabolism; D010064:Embryo Implantation / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism*; D007473:Ion Channels / Q000096:biosynthesis* / Q000235:genetics; D024101:Mitochondrial Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D000071246:Uncoupling Protein 2
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2