Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses.
The Killer Ig-like receptors (KIRs) on NK cells regulate NK activity via the recognition of specific HLA class I products on the surface of target cells. To investigate the level at which these genetically polymorphic receptors and ligands influence HIV-1 disease progression, we examined the effect of KIR and HLA genotype on HIV outcome. We observed a significant association between particular combinations of KIR epitopes expressed by HLA-B/-C haplotypes and propose that the repertoire of KIR epitopes expressed by HLA-B and HLA-C alleles within the context of particular haplotypes may be an important component of the NK mediated immune response to HIV and/or other infectious pathogens.
Gaudieri
Silvana
S
Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, Perth, WA, Australia.
Nolan
David
D
McKinnon
Elizabeth
E
Witt
Campbell S
CS
Mallal
Simon
S
Christiansen
Frank T
FT
D005787:Gene Frequency; D005828:Genetics, Population; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology*; D015497:HIV-1; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D015236:HLA-C Antigens / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D016056:Immunodominant Epitopes / Q000235:genetics / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D015810:Linkage Disequilibrium; D011971:Receptors, Immunologic / Q000235:genetics* / Q000276:immunology; D054340:Receptors, KIR
D015235:HLA-B Antigens; D015236:HLA-C Antigens; D016056:Immunodominant Epitopes; D011971:Receptors, Immunologic; D054340:Receptors, KIR