Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720.
ICC-1132, a recombinant virus-like particle comprising of a modified hepatitis B core protein with a B cell (NANP) and two T cell epitopes of Plasmodium falciparum circumsporozoite protein (CSP), was administered i.m. as a single 50 microg dose in Seppic ISA 720 to 11 volunteers. Local reactogenicity and systemic side effects were acceptable with the predominant finding being mild pain at the injection site. This regimen induced anti-NANP antibodies in 10/11 and modest T cell responses. There was no evidence of protection from experimental challenge with P. falciparum sporozoites. Other formulations and/or multi-dose regimens will be required to enhance the immunogenicity and efficacy of ICC-1132.
Walther
Michael
M
Nuffield Department of Clinical Medicine, Centre for Clinical Vaccinology and Tropical Medicine, Oxford University, Old Road, Headington, Oxford OX3 7LJ, UK. Michael.walther@ndm.ox.ac.uk
Dunachie
Susanna
S
Keating
Sheila
S
Vuola
Jenni M
JM
Berthoud
Tamara
T
Schmidt
Annette
A
Maier
Carolin
C
Andrews
Laura
L
Andersen
Rikke F
RF
Gilbert
Sarah
S
Poulton
Ian
I
Webster
Daniel
D
Dubovsky
Filip
F
Tierney
Eveline
E
Sarpotdar
Pramod
P
Correa
Simon
S
Huntcooke
Angela
A
Butcher
Geoffrey
G
Williams
Jack
J
Sinden
Robert E
RE
Thornton
George B
GB
Hill
Adrian V S
AV
D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D018984:Epitopes, T-Lymphocyte / Q000008:administration & dosage / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology* / Q000469:parasitology*; D005260:Female; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D017780:Malaria Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000235:genetics / Q000276:immunology*; D016778:Malaria, Falciparum / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control; D008297:Male; D010963:Plasmodium falciparum / Q000276:immunology*; D034101:Sporozoites / Q000276:immunology
D018984:Epitopes, T-Lymphocyte; D017780:Malaria Vaccines