A monoclonal antibody driven biodiagnostic system for the quantitative screening of breast cancer.
A prospective clinical parametric study comprising women afflicted by breast cancer and otherwise healthy participants was undertaken. The mean plasmatic concentration of putative leucine amino peptidase and nucleoside diphosphate phosphotransferase enzymatic complex in breast cancer cases was significantly elevated [43.9 +/- 2.8 microg ml(-1) (n = 9)] when compared to those found in otherwise healthy women [8.07 +/- 0.14 microg ml(-1) (n = 8)]. Women without images compatible with any tumours (n = 13) had a mean concentration of 10.77 +/- 1.49 microg ml(-1). The mean value obtained in women with fibroadenomas was 10.15 +/- 0.81 microg ml(-1) (n = 6) and with cystic fibrosis mastopathy 8.75 +/- 0.28 microg ml(-1) (n = 7). The efficacy of a tandem quantitative biodiagnostic system as a parametric screening tool for the early detection of breast cancer is underlined, raising the possibility of increasing the cost effectiveness of current imaging non-parametric technologies.
Pulido-Cejudo
Gabriel
G
The Canadian Breast Cancer Laboratories, Canbreal Therodiagnostics International Inc. 600 Peter Morand Crescent Suite 330, Ottawa, Ontario, K1G 5Z3, Canada. gpulido@canbreal.com
Miranda
Hernando
H
El Abdaimi
Khadija
K
Wang
Chen
C
Kar
Bratati
B
Medina Acevedo
Jorge
J
Cárdenas
José Manuel
JM
Sarti Gutiérrez
Elsa
E
Pérez Palacios
Gregorio
G
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000097:blood* / Q000276:immunology; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis*; D003365:Costs and Cost Analysis; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D018226:Fibroadenoma / Q000097:blood / Q000175:diagnosis*; D005348:Fibrocystic Breast Disease / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007931:Leucyl Aminopeptidase / Q000097:blood; D008403:Mass Screening / Q000191:economics / Q000379:methods*; D008875:Middle Aged; D009097:Multienzyme Complexes / Q000097:blood* / Q000276:immunology; D009701:Nucleoside-Diphosphate Kinase / Q000097:blood; D011237:Predictive Value of Tests
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D009097:Multienzyme Complexes; D009701:Nucleoside-Diphosphate Kinase; D007931:Leucyl Aminopeptidase