title: Site-selective Pd-catalyzed coupling of 1,4-diiodo-1,3-alkadienes with Grignard reagents and its application to the synthesis of fulvenes.
abstract: [reaction: see text] The coupling reaction of 1,4-diiodo-1,3-alkadienes with a Grignard reagent in the presence of a catalytic amount of Pd(PPh3)4 proceeded with excellent site-selectivity. Synthetic application of the reaction was demonstrated by a regio- and stereoselective synthesis of 1,3,6-trisubstituted fulvenes.
authors.affiliation: Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Uemura
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Takayama
authors.forename: Fumie
authors.initials: F
authors.lastname: Sato