title: Relation of hepatolithiasis to helminthic infestation.
abstract: OBJECTIVE
  The relation of helminthic infestation to hepatolithiasis is a subject of dispute. This case-control study was undertaken to evaluate the prevalence of helminthiasis in hepatolithiasis patients and to compare the clinicopathological features of hepatolithiasis between patients with and without helminthiasis.
  
  
  METHODS
  The prevalence of ascariasis or clonorchiasis was evaluated using ELISA in 131 patients with hepatolithiasis who were treated at Show-Chwan Memorial Hospital and 121 subjects who constituted a control group. The patients' detailed histories and medical charts were reviewed.
  
  
  RESULTS
  The prevalence of positive immunodiagnosis of ascariasis and clonorchiasis was higher in patients with hepatolithiasis than in control subjects (33.6%, 44/131 vs 17.4%, 21/121, odds ratio [OR] = 2.41, 95% confidence interval [CI] = 1.28-4.56, P = 0.005; and 6.9%, 9/131 v 0.8%, 1/121, OR = 8.85, 95% CI = 1.12-188.69, P = 0.02). Patients with helminthiasis rarely had concurrent gallbladder stones (26%, 12/47 vs 55%, 46/84, OR = 0.28, 95% CI = 0.12-0.66, P = 0.002). Prior to the diagnosis of hepatolithiasis in adulthood, most of the patients with helminthiasis tended to have a history of recurrent abdominal pain in their childhood and an asymptomatic 'lucid interval' during their teenage years (70.2%, 33/47 vs 39.3%, 33/84, OR = 3.64, 95% CI = 1.59-8.42, P = 0.0005). However, the prevalence of intrahepatic duct stricture (38.3%, 18/47 vs 40.5%, 34/84, OR = 0.91, 95% CI = 0.41-2.02, P > 0.05), secondary biliary cirrhosis (6.4%, 3/47 vs 3.6%, 3/84, OR = 1.84, 95% CI = 0.28-12.03, P > 0.05), cholangiocarcinoma (2.1%, 1/47 vs 0%, 0/84, OR = approximately , P > 0.05), and stone recurrence (54.8%, 24/42 vs 50.0%, 38/76, OR = 1.33, 95% CI = 0.58-3.06, P > 0.05) did not significantly increase.
  
  
  CONCLUSIONS
  Helminthiasis is a possible risk factor for hepatolithiasis, although it is unlikely to increase the incidence of complications, including bile duct stricture, secondary biliary cirrhosis, and cholangiocarcinoma. Patients with helminthiasis tend to have a history of an asymptomatic 'lucid interval' between the periods of recurrent abdominal pain in their childhood and the diagnosis of hepatolithiasis in their adulthood.
authors.affiliation: Digestive Disease Center, Show-Chwan Memorial Hospital, Changhua, Taiwan.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Huang
authors.forename: Chien-Hua
authors.initials: CH
authors.lastname: Chen
authors.forename: Chuan-Min
authors.initials: CM
authors.lastname: Yen
authors.forename: Jee-Chun
authors.initials: JC
authors.lastname: Yang
authors.forename: Chi-Chieh
authors.initials: CC
authors.lastname: Yang
authors.forename: Yung-Hsiang
authors.initials: YH
authors.lastname: Yeh
authors.forename: Der-Aur
authors.initials: DA
authors.lastname: Chou
authors.forename: Sen-Kou
authors.initials: SK
authors.lastname: Yueh
authors.forename: Yu-Yen
authors.initials: YY
authors.lastname: Yang
authors.forename: Chiu-Kuei
authors.initials: CK
authors.lastname: Nien
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001196:Ascariasis / Q000150:complications* / Q000453:epidemiology*; D002137:Calculi / Q000150:complications*; D016022:Case-Control Studies; D003003:Clonorchiasis / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015995:Prevalence