title: Effect of nerve cell currents on MRI images in snail ganglia.
abstract: We performed extracellular potential recording with dissected snail ganglia inside an MRI scanner to investigate correlation between neuronal activity and MR image intensity. To increase neuronal activity we applied a nitric oxide donor, sodium-nitrosocystein, to the ganglia. The MR image intensity change in the ganglia region is correlated with the neuronal activity and was up to 5.49+/-1.94%. Since the snail has non-magnetic hemocyanins as oxygen carrying protein, it seems that the image intensity change is mainly due to the local magnetic fields produced by the neuronal currents.
authors.affiliation: Graduate School of East-West Medical Science, Kyung Hee University, 1 Seochun, Kiheung, Yongin, Kyungki 449-701, Korea.
authors.forename: Tae S
authors.initials: TS
authors.lastname: Park
authors.forename: Sang Y
authors.initials: SY
authors.lastname: Lee
authors.forename: Ji-Ho
authors.initials: JH
authors.lastname: Park
authors.forename: Soo Y
authors.initials: SY
authors.lastname: Lee
mesh_terms: D000818:Animals; D017952:Ganglia, Invertebrate / Q000166:cytology*; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging; D008564:Membrane Potentials / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D012908:Snails