title: Synthesis of optically active constrained 2-substituted norstatines: a straightforward application of Seebach's "SRS" synthetic principle.
abstract: A straightforward two-step methodology of synthesis of optically active (2R)-substituted norstatines via addition of N-tert-butoxycarbonyl-substituted aldimines to (2S)-chiral enolates of 1,3-dioxolan-4-ones has been developed. In particular, the use of the natural (2S)-malic acid is examined for the synthesis of potential GABAergic spirocyclic gamma-lactams.
authors.affiliation: Istituto CNR per la Sintesi Organica e Fotoreattività I.S.O.F., Area della Ricerca di Bologna, via P. Gobetti 101, 40129 Bologna, Italy. battaglia@isof.cnr.it
authors.forename: Arturo
authors.initials: A
authors.lastname: Battaglia
authors.forename: Andrea
authors.initials: A
authors.lastname: Guerrini
authors.forename: Carlo
authors.initials: C
authors.lastname: Bertucci