Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups.
The synthesis of potential beta-turn mimetics based on cyclic sulfonamide peptoid/peptoid hybrids is described. These are readily synthesized using a solid phase protocol followed by cyclization in solution, and their suitability to combinatorial approaches is illustrated by the synthesis of a small but diversely functionalized library.
Wels
Bas
B
Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
Kruijtzer
John A W
JA
Garner
Keith M
KM
Adan
Roger A H
RA
Liskamp
Rob M J
RM
D003500:Cyclization; D008956:Models, Chemical; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D044105:Receptor, Melanocortin, Type 4 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology
D010456:Peptides, Cyclic; D044105:Receptor, Melanocortin, Type 4; D013449:Sulfonamides