Identification of diadenosine-triphosphate in mature bovine lenses.
Mature bovine lenses contain 75-100 microM of a previously unidentified nucleoside polyphosphate. Using (31)P NMR spectroscopy we have identified this compound as diadenosine-5',5'''-triphosphate. The accumulation of this compound in the lens may be a consequence of the high levels of activities of t-RNA synthetases during lens differentiation and growth. The function, if any, of this compound in the bovine lenses is presently unknown.
Szwergold
Benjamin S
BS
Dartmouth Medical School, Hanover, NH, USA. szwergold@dartmouth.edu
Lal
Sundeep
S
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D002417:Cattle; D015226:Dinucleoside Phosphates / Q000032:analysis* / Q000737:chemistry*; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000737:chemistry* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
D015226:Dinucleoside Phosphates; C011440:diadenosine triphosphate