Leukemia and the nervous system.
Leukemia affects the central and peripheral nervous system. Neurologic complications are a consequence of direct leukemic infiltration, as occurs with leukemic meningitis, and due to complications of either antileukemic treatment (thrombocytopenic or disseminated intravascular coagulation-related intracranial hemorrhage, steroid myopathy, vinca alkaloid peripheral neuropathy) or immune compromise (Herpes zoster shingles or Aspergillus meningitis).
Chamberlain
Marc C
MC
Department of Neurology, University of Southern California, Norris Comprehensive Cancer Center and Hospital, 1441 Eastlake Avenue, Room 3459, Los Angeles, CA 90033, USA. chamberl@usc.edu
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000150:complications* / Q000175:diagnosis; D018450:Disease Progression; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007107:Immune System; D007938:Leukemia / Q000175:diagnosis* / Q000473:pathology*; D008581:Meningitis / Q000209:etiology / Q000473:pathology; D009420:Nervous System / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000175:diagnosis; D013117:Spinal Cord Compression
D000970:Antineoplastic Agents