Neoplastic meningitis-related encephalopathy: prognostic significance.
Two cohorts of 20 patients diagnosed with neoplastic meningitis (NM) with or without encephalopathy were matched with respect to age, sex, primary tumor, and performance status. Median survival was 10 weeks (range 6 to 20 weeks) in the cohort with NM-related encephalopathy compared to 24 weeks (range 8 to 40 weeks) in the cohort without NM-related encephalopathy (p < 0.001). NM-related encephalopathy is a clinical variable that predicts for poor survival in patients with NM.
Chamberlain
Marc C
MC
Department of Preventive Medicine, USC/Norris Cancer Center, University of Southern California, Los Angeles, USA. ChambeMC@moffitt.usf.edu
Tsao-Wei
Denice
D
Groshen
Susan
S
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000150:complications / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary*; D015331:Cohort Studies; D003131:Combined Modality Therapy; D003221:Confusion / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D015993:Life Tables; D008297:Male; D008545:Melanoma / Q000150:complications / Q000401:mortality / Q000556:secondary; D008577:Meningeal Neoplasms / Q000150:complications / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary*; D008582:Meningitis, Aseptic / Q000209:etiology* / Q000401:mortality / Q000532:radiotherapy; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis