[Inhibition of respiratory syncytial virus (RSV) by moroxydine, allicin, alpha-interferon and their joint application].
This paper reported the inhibition of respiratory syncytial virus by Moroxydine (ABOB), Allicin, alpha-interferon and their joint application. The results indicated that each of the three drugs inhibited RSV in HeLa cells, and the effective dosage of ABOB was 100 mg/L, alpha-interferon 1.5 x 10(4) U/L and Allicin one eight hundred thousandth of the pure material. The combinations of 3 drugs showed synergism without antagonism, this not only decreased the dosage, toxicity but also enhanced the inhibition effects on respiratory syncytial virus obviously.
Zhou
G
G
Yantai Health and Anti-epidemic Station, Shandong Yantai 264001.
Han
S
S
Shi
Y
Y
Sui
H
H
D001645:Biguanides; D004220:Disulfides; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006367:HeLa Cells; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D009025:Morpholines / Q000494:pharmacology*; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy* / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000187:drug effects*; D013441:Sulfinic Acids / Q000494:pharmacology*
D001645:Biguanides; D004220:Disulfides; D016898:Interferon-alpha; D009025:Morpholines; D013441:Sulfinic Acids; C006452:allicin; C005267:moroxydine