title: Caffeine: a valuable tool to study central fatigue in humans?
abstract: This review focuses on caffeine's effects on the central modulation of muscle activation in humans. The drug's effects on voluntary muscle activation, the Hoffman reflex, motor-evoked potentials, self-sustained firing, pain, and sensation are discussed, and the possibility that caffeine maybe useful in the study of central fatigue is explored.
authors.affiliation: Department of Biology and 2School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
authors.forename: Jayne M
authors.initials: JM
authors.lastname: Kalmar
authors.forename: E
authors.initials: E
authors.lastname: Cafarelli
mesh_terms: D002110:Caffeine / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D019054:Evoked Potentials, Motor / Q000187:drug effects; D015444:Exercise / Q000502:physiology*; D005221:Fatigue / Q000378:metabolism*; D006801:Humans; D009044:Motor Cortex / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000294:innervation; D011930:Reaction Time; D011985:Receptors, Serotonin / Q000187:drug effects
chemical_list: D000697:Central Nervous System Stimulants; D011985:Receptors, Serotonin; D002110:Caffeine