title: Retrovirus restriction factors.
abstract: A number of cellular genes have recently been identified that actively inhibit retrovirus replication and so protect cells from infection. The genes target many distinct steps in the viral life cycle: entry, viral DNA synthesis, intracellular movement of viral nucleic acids, and viral gene expression. These restriction systems constitute newly appreciated components of an innate immunity that may be important for survival of a host exposed to retrovirus infection. It may someday be possible to enhance or activate these systems to induce antiviral states.
authors.affiliation: Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, 701 West 168th Street, New York, NY 10032, USA. goff@cancercenter.columbia.edu
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Goff
mesh_terms: D000818:Animals; D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins / Q000378:metabolism; D003562:Cytidine / Q000378:metabolism; D004279:DNA, Viral / Q000378:metabolism; D006801:Humans; D008253:Macaca mulatta; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D011506:Proteins / Q000378:metabolism; D016601:RNA-Binding Proteins; D051381:Rats; D012190:Retroviridae / Q000378:metabolism*; D000070584:Tripartite Motif Proteins; D044767:Ubiquitin-Protein Ligases; D014779:Virus Replication / Q000502:physiology*
chemical_list: D000090103:Antiviral Restriction Factors; D002352:Carrier Proteins; D004279:DNA, Viral; C103189:Fv1 protein, mouse; C103555:Fv4 protein, mouse; D008565:Membrane Proteins; D011506:Proteins; D016601:RNA-Binding Proteins; D000070584:Tripartite Motif Proteins; C465959:Zc3hav1 protein, rat; D003562:Cytidine; C477346:TRIM5 protein, human; D044767:Ubiquitin-Protein Ligases