Nitric oxide in postmenopausal women taking three different HRT regimens.
OBJECTIVE
To search and compare the effects of three different HRT regimens on nitric oxide levels of postmenopausal women.


METHODS
Four groups of postmenopausal women were included in this prospective, randomised, placebo controlled study. 34 women used 0.625 mg conjugated estrogen continuously combined with 5 mg medroxyprogesterone acetate, 32 women used 2.5 mg tibolone, 26 women used 50 mcg transdermal estrogen alone continuously and 32 women used placebo for 12 months. Before the treatment and after 1 year, serum NO (nitrate/nitrite) and some other biochemical parameters were evaluated.


RESULTS
All HRT using groups had increased serum nitric oxide levels significantly compared to placebo group and also there was not any difference among three HRT using groups concerning to increases in nitric oxide levels.


CONCLUSIONS
Both conjugated estrogen combined with continuous progestin and transdermal estrogen alone and also tibolone increases serum nitric oxide levels of postmenopausal women equally for 12-months of treatment.
Kesim
M D
MD
Third Obstetrics and Gynecology Clinic, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
Aydin
Y
Y
Erdemir
M
M
Atis
A
A
D000279:Administration, Cutaneous; D003271:Contraceptive Agents, Female / Q000627:therapeutic use; D020847:Estrogen Receptor Modulators / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy / Q000379:methods*; D004967:Estrogens / Q000627:therapeutic use; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D009652:Norpregnenes / Q000627:therapeutic use; D017698:Postmenopause; D011446:Prospective Studies
D003271:Contraceptive Agents, Female; D020847:Estrogen Receptor Modulators; D004967:Estrogens; D004966:Estrogens, Conjugated (USP); D009652:Norpregnenes; D009569:Nitric Oxide; D017258:Medroxyprogesterone Acetate; C027385:tibolone