Relationship between bone resorption and adrenal sex steroids and their derivatives in oophorectomized women.
OBJECTIVE
To clarify the role of adrenal sex steroids and their derivatives on bone resorption in oophorectomized women.


METHODS
Cross-sectional study.


METHODS
Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University.


METHODS
Forty-eight women who were within one year of bilateral oophorectomy were recruited for this study.


METHODS
None of the subjects were treated with the drugs affecting bone metabolism.


METHODS
Urinary deoxypyridinoline (Dpyr) as marker of bone resorption and serum DHEAS, androstenedione (A-dione), testosterone (T) and estrone (E1) levels as adrenal sex steroids and their derivatives.


RESULTS
There was an inverse correlation between urinary Dpyr and serum concentrations of E1, DHEAS, or A-dione. There was no significant relationship between urinary Dpyr and T.


CONCLUSIONS
These results suggest that adrenal steroids and their derivatives may influence the bone resorption in oophorectomized women.
Nozaki
M
M
Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. nozaki@med.kyushu-u.ac.jp
Hashimoto
K
K
Nakano
H
H
D000328:Adult; D000596:Amino Acids / Q000652:urine; D000735:Androstenedione / Q000097:blood*; D001862:Bone Resorption / Q000097:blood* / Q000652:urine; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D004970:Estrone / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010052:Ovariectomy; D013739:Testosterone / Q000097:blood
D000596:Amino Acids; D004970:Estrone; D013739:Testosterone; D000735:Androstenedione; D019314:Dehydroepiandrosterone Sulfate; C036020:deoxypyridinoline; D003404:Creatinine