Heart healthy equals prostate healthy equals statins: the next cancer chemoprevention trial. Part II.
OBJECTIVE
Specific ongoing observations from diverse medical studies do not serve to belittle the impact of prostate or other cancers, but the overall impact of cardiovascular disease (CVD) in individuals at high-risk or in individuals that have been diagnosed with common cancers needs to be addressed by future research. CVD has been the number one cause of death in men and women since the year 1990. Serum cholesterol levels are some of the most accurate long-term predictors of all-cause mortality. CVD has been the number one cause of death in the largest dietary supplement cancer chemoprevention trials.


RESULTS
The potential for utilizing a cancer chemoprevention agent that may simultaneously reduce the risk of CVD and cancer is not only attractive, but several agents are available immediately that may demonstrate this unique impact. For example, recently statin drugs, low-dose aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), and even fish oil supplements may be utilized in the next major cancer chemoprevention trial.


CONCLUSIONS
Heart healthy agents and interventions seem to also exhibit the ability to be prostate healthy. In addition, their low cost and potential to reduce all-cause mortality may also ensure good compliance. Statins and other heart healthy agents should be considered to be the next most ideal interventions to be utilized in the next major chemoprevention trial, especially now because several popular past dietary supplements and drugs have demonstrated the potential for notable side effects and an inability to impact the risk of CVD.
Moyad
Mark A
MA
Department of Urology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0330, USA. moyad@umich.edu
D002318:Cardiovascular Diseases / Q000150:complications / Q000401:mortality* / Q000517:prevention & control; D002423:Cause of Death; D002986:Clinical Trials as Topic; D019049:Developed Countries / Q000706:statistics & numerical data*; D019587:Dietary Supplements; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000150:complications / Q000401:mortality* / Q000517:prevention & control; D014481:United States / Q000453:epidemiology