title: The ways of PARP.
abstract: Two papers in this issue of Cell describe two roles of poly(ADP-ribose) polymerase (PARP) in modulating chromatin structure: as a structural component replacing linker histone (Kim et al., 2004) and as a constituent of a corepressor complex poised to dismiss repression upon receipt of an activating signal (Ju et al., 2004).
authors.affiliation: Department of Molecular Biology and Biochemistry, Nelson Laboratories, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Pirrotta
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009707:Nucleosomes / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D000072056:Transcription Factor HES-1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002843:Chromatin; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins; D006026:Glycoside Hydrolases; D006657:Histones; D018398:Homeodomain Proteins; D046911:Macromolecular Substances; D009243:NAD; D009707:Nucleosomes; D011065:Poly(ADP-ribose) Polymerases; D012097:Repressor Proteins; D000072056:Transcription Factor HES-1; C489735:Hes1 protein, rat; C499043:TLE1 protein, human; C091023:gro protein, Drosophila; C022407:poly ADP-ribose glycohydrolase