Basal cell carcinoma in childhood after radiation therapy: case report and review.
We describe 2 patients who received ionizing radiation as part of a curative regimen for childhood malignancy which later developed basal cell carcinoma at an early age. They do not occur within the context of well-defined syndromes, such like basal cell nevus syndrome, albinism, or xeroderma pigmentosum. Basal cell carcinomas appears on radiated areas in older individuals, less often in younger patients, in which the period of latency between exposure to radiation and the appearance of basal cell carcinomas is shorter than in older patients. Our 2 cases presented a period of latency of 11 and 10 years. Radiated skin areas must be explored as part of the follow-up in children who received radiotherapy and should probably be maintained for life. The basal cell carcinoma in childhood is best treated by excision.
Marín-Gutzke
Martina
M
Department of Plastic Surgery, Children's Hospital Niño Jesus, Madrid, Spain. maringutzke@yahoo.com
Sánchez-Olaso
Alberto
A
Berenguer
Beatriz
B
González
Beatriz
B
Rodríguez
Pilar
P
De Salamanca
Javier Enríquez
JE
De Prada
Inmaculada
I
D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D002280:Basal Cell Carcinoma / Q000209:etiology* / Q000601:surgery; D002675:Child, Preschool; D004806:Ependymoma / Q000188:drug therapy / Q000532:radiotherapy; D006258:Head and Neck Neoplasms / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000601:surgery; D017253:Neurofibromatoses / Q000188:drug therapy / Q000532:radiotherapy; D020339:Optic Nerve Glioma / Q000188:drug therapy / Q000532:radiotherapy; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012878:Skin Neoplasms / Q000209:etiology* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome