Acquired macroglossia due to lopinavir/ritonavir treatment.
A HIV-positive patient, 3 months after the treatment initiation with lopinavir-/ritonavir (LPV/r) acquired macroglossia. The tongue biopsy revealed mature adipose tissue accumulated into submucosa. The drug was discontinued and the patient showed a significant improvement. This case is the first case in the medical literature of acquired macroglossia because of LPV/r, a drug causing changes in body fat composition.
Vritsali
Eleni
E
Specific Infectious Disease Unit, AHEPA General Hospital of Thessaloniki, Thessaloniki, Greece.
Kolokotronis
Alexandros
A
Valagouti
Despina
D
Miteloudis
Georgios
G
Zaraboukas
Thomas
T
Kioses
Vassilios
V
Antoniades
Demetrios
D
D000368:Aged; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006801:Humans; D061466:Lopinavir; D008260:Macroglossia / Q000139:chemically induced* / Q000473:pathology; D011744:Pyrimidinones / Q000009:adverse effects* / Q000627:therapeutic use; D019438:Ritonavir / Q000009:adverse effects* / Q000627:therapeutic use
D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D061466:Lopinavir; D019438:Ritonavir