Preparation of indapamide slow-release pellets.
During the process of developing a slow-release formulation of indapamide, researchers created a drug-containing pellet coated with Eudragit RS100 (Rohm GMbH & Co. KG, Darmstadt, Germany) to control the rate at which the drug was released. The two main variables were the agglomerants used in the pellet preparation and the amount of Eudragit RS100 used to coat them. The optimal outcome was indicated by the greatest number of drug-containing pellets recovered through an 18- to 24-mesh sieve and a satisfactory 24-hour release curve. The kinetics of dissolution fit the Higuchi kinetics model. Stability tests of the drug pellets showed no notable changes in the rate of drug release, related substances (mean byproducts or impurities from interactions or decompositions), and drug content.
Jia
Wei
W
School of Pharmacy, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China.
Qiu
Mingfeng
M
Sun
Xia
X
Qiu
Yungping
Y
Su
Mingming
M
D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D002681:China; D002851:Chromatography, High Pressure Liquid; D017321:Clinical Trials, Phase I as Topic; D003692:Delayed-Action Preparations; D004304:Dosage Forms; D006801:Humans; D007190:Indapamide / Q000494:pharmacology* / Q000627:therapeutic use; D011358:Product Surveillance, Postmarketing; D012680:Sensitivity and Specificity; D013608:Tablets, Enteric-Coated / Q000737:chemistry
D003692:Delayed-Action Preparations; D004304:Dosage Forms; D013608:Tablets, Enteric-Coated; D007190:Indapamide