title: Existence of two forms of L protein of Newcastle disease virus isolates due to a compensatory mutation in Domain V.
abstract: Nucleotide sequence comparison of the L gene of the Malaysian neurotropic-viscerotropic velogenic NDV strain AF2240 with other NDV strains revealed a single nucleotide insertion at position 3870. This mutation is compensated by a nucleotide deletion downstream at position 3958 which results in two forms of the L proteins containing a 30-amino acid substitution in Domain V. This compensatory mutation does not correlate with the pathogenicity of the viral strains but it may affect the viral replication as Domain V is believed to play an important role in the replication of paramyxoviruses.
authors.affiliation: Department of Biochemistry and Microbiology, Faculty of Science and Environmental Studies, Serdang, Malaysia.
authors.forename: E
authors.initials: E
authors.lastname: Kusumaningtyas
authors.forename: W S
authors.initials: WS
authors.lastname: Tan
authors.forename: Z
authors.initials: Z
authors.lastname: Zamrod
authors.forename: M
authors.initials: M
authors.lastname: Eshaghi
authors.forename: K
authors.initials: K
authors.lastname: Yusoff
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001483:Base Sequence; D016368:Frameshift Mutation; D008969:Molecular Sequence Data; D009522:Newcastle disease virus / Q000235:genetics*; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics*
chemical_list: D014764:Viral Proteins