[Effects of Chinese herbs for cool-moistening and freeing collaterals on serum gastrin and surface electrogastrogram in patients of diabetes mellitus with gastroparesis].
OBJECTIVE
To explore the effect of Chinese herbs (CH) for cool-moistening and freeing collaterals on gastro-dynamic disturbance in patients of diabetes mellitus type 2 with gastroparesis (DM-GP).


METHODS
Fifty-three patients of DM-GP were enrolled and treated with CH (n = 28) and Cisapride (n = 25) respectively for 4 weeks, the changes of gastrin and electro-gastrogram (EGG) before and after treatment were observed.


RESULTS
After treatment, the EGG improved significantly, showing the rhythm significantly improved, and level of serum gastrin lowered significantly, as compared with those before treatment, the difference was significant (P<0.01), but insignificant difference was found between the two groups. Fifteen patients in each group were followed-up afar stopping medication for 3 months, recurrence occurred in 1 patient of CH treated group, and 2 patients of Cisapride treated group. No adverse reaction was found in the rest patients.


CONCLUSIONS
CH could obviously improve the gastro-intestinal motility and hormones abnormality.
Rong
Shi-ling
SL
TCM Hospital, Hebei Medical University, Shijiazhuang (050011). hbrongsl@eyou.com
Li
Dian-gui
DG
Fan
Hong-mei
HM
Zheng
Yanping
Y
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D004576:Electromyography; D004594:Electrophysiology; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005755:Gastrins / Q000097:blood*; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005769:Gastrointestinal Motility / Q000187:drug effects; D018589:Gastroparesis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal; D005755:Gastrins; D005765:Gastrointestinal Agents