title: Late onset of serologic positive titers in a patient with Parinaud's oculoglandular syndrome.
abstract: OBJECTIVE
  To report a case of Parinaud's oculoglandular syndrome (POS) in which, despite the initially negative, a late onset of serologic positive titers was observed.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 65-year-old man was examined for a foreign body in the left eye associated with granulomatous nodule on the palpebral conjuctiva, chemosis and a swollen preauricular lymph node. Despite the initially negative serologic titers to Bartonella henselae, a clinical diagnosis of POS was made and treatment was instituted initially with oral ciprofloxacin (500 mg twice a day). Three weeks later, serologic positive titers were found which confirmed the diagnosis of POS.
  
  
  CONCLUSIONS
  Even though the improvements in diagnostic testing such as indirect immunofluorescence antibody, negative titles could be initially observed, confusing the diagnostic process. Other techniques (such as polymerase chain reaction (PCR) testing) should be also taken into consideration in cases with increased clinical suspicious of B. henselae indections.
authors.affiliation: Department of Ophthalmology, University of Crete, Medical School, Heraklion, Greece. kymionis@med.uoc.gr
authors.forename: George D
authors.initials: GD
authors.lastname: Kymionis
authors.forename: Charalambos S
authors.initials: CS
authors.lastname: Siganos
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Pallikaris
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood*; D018416:Bartonella henselae / Q000276:immunology*; D002372:Cat-Scratch Disease / Q000175:diagnosis* / Q000382:microbiology*; D002939:Ciprofloxacin / Q000627:therapeutic use; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis / Q000382:microbiology; D008297:Male; D015835:Ocular Motility Disorders / Q000175:diagnosis / Q000382:microbiology*; D012698:Serologic Tests
chemical_list: D000890:Anti-Infective Agents; D000907:Antibodies, Bacterial; D002939:Ciprofloxacin