T1DBase, a community web-based resource for type 1 diabetes research.
T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D susceptibility and pathogenesis. It includes the following datasets: annotated genome sequence for human, rat and mouse; information on genetically identified T1D susceptibility regions in human, rat and mouse, and genetic linkage and association studies pertaining to T1D; descriptions of NOD mouse congenic strains; the Beta Cell Gene Expression Bank, which reports expression levels of genes in beta cells under various conditions, and annotations of gene function in beta cells; data on gene expression in a variety of tissues and organs; and biological pathways from KEGG and BioCarta. Tools on the site include the GBrowse genome browser, site-wide context dependent search, Connect-the-Dots for connecting gene and other identifiers from multiple data sources, Cytoscape for visualizing and analyzing biological networks, and the GESTALT workbench for genome annotation. All data are open access and all software is open source.
Smink
Luc J
LJ
Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge CB2 2XY, UK. Luc.Smink@cimr.cam.ac.uk
Helton
Erin M
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Healy
Barry C
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Cavnor
Christopher C
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Lam
Alex C
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Flamez
Daisy
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Burren
Oliver S
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Wang
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Dolman
Geoffrey E
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Burdick
David B
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Everett
Vincent H
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Gustavo
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Laneri
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Rowen
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Schuilenburg
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Walker
Neil M
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Mychaleckyj
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Wicker
Linda S
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Eizirik
Decio L
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Todd
John A
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Goodman
Nathan
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D000818:Animals; D035843:Biomedical Research; D003628:Database Management Systems; D030541:Databases, Genetic; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D004195:Disease Models, Animal; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D023281:Genomics; D006801:Humans; D020407:Internet; D007515:Islets of Langerhans / Q000378:metabolism; D051379:Mice; D051381:Rats; D014584:User-Computer Interface