Protein kinase C in cardiac disease and as a potential therapeutic target.
Protein kinase C (PKC) is a member of a large family of serine/threonine kinases that plays an integral role in many of the signaling cascades that govern cellular behavior. As such, it is intricately involved in the processes that mediate disease pathogenesis. Strategies that serve to alter PKC function may prove to be useful in the treatment of numerous disease states. This article reviews the various roles PKC may play in cardiovascular disease, specifically with regard to ischemic heart disease, cardiac hypertrophy, heart failure, hypertension, and atherosclerosis, and suggests the potential for developing therapeutic approaches that can target PKC activity.
Murphy
Stephen
S
Department of Internal Medicine, University of Colorado School of Medicine, Denver, CO, USA.
Frishman
William H
WH
D001161:Arteriosclerosis / Q000201:enzymology; D023903:Coronary Restenosis / Q000201:enzymology; D006333:Heart Failure / Q000201:enzymology; D006801:Humans; D006973:Hypertension / Q000201:enzymology; D017379:Hypertrophy, Left Ventricular / Q000201:enzymology; D019157:Ischemic Preconditioning, Myocardial; D017202:Myocardial Ischemia / Q000201:enzymology*; D011493:Protein Kinase C / Q000378:metabolism*
D011493:Protein Kinase C