Interaction of bismuth subsalicylate with fruit juices, ascorbic acid, and thiol-containing substrates to produce soluble bismuth products active against Clostridium difficile.
Bismuth subsalicylate (BSS), the active ingredient of Pepto-Bismol, has been used for many years to treat various disorders of the gastrointestinal tract. Using mass spectrometry and the agar dilution method, we determined that insoluble BSS interacts with certain dietary components and organic substrates to produce water-soluble products with activity against Clostridium difficile.
Mahony
D E
DE
Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7. David.E.Mahony@Dal.Ca
Woods
A
A
Eelman
M D
MD
Burford
N
N
Veldhuyzen van Zanten
S J O
SJ
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001205:Ascorbic Acid / Q000737:chemistry* / Q000494:pharmacology; D001628:Beverages; D001729:Bismuth / Q000737:chemistry / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects*; D004347:Drug Interactions; D005638:Fruit; D006801:Humans; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D012459:Salicylates / Q000737:chemistry / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D012459:Salicylates; D013438:Sulfhydryl Compounds; C015715:bismuth subsalicylate; D001205:Ascorbic Acid; D001729:Bismuth