title: Cerebellar atrophy in temporal lobe epilepsy affects procedural memory.
abstract: The authors examined a cognitive function mediated by the cerebellum, classical eyeblink conditioning, and its relationship to cerebellar volume in healthy controls (n = 59) and temporal lobe epilepsy subjects (n = 77). Controls demonstrated better conditioning, larger cerebellar volumes, and an association between conditioning and cerebellar volume that was not observed in epilepsy patients. These findings provide support for the hypothesis that cerebellar atrophy in epilepsy affects procedural memory.
authors.affiliation: Matthews Neuropsychology Lab, Department of Neurology, University of Wisconsin, 600 N. Highland, Madison, WI 53792, USA. hermann@neurology.wisc.edu
authors.forename: B
authors.initials: B
authors.lastname: Hermann
authors.forename: M
authors.initials: M
authors.lastname: Seidenberg
authors.forename: L
authors.initials: L
authors.lastname: Sears
authors.forename: R
authors.initials: R
authors.lastname: Hansen
authors.forename: K
authors.initials: K
authors.lastname: Bayless
authors.forename: P
authors.initials: P
authors.lastname: Rutecki
authors.forename: C
authors.initials: C
authors.lastname: Dow
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000388:Air; D001284:Atrophy; D001767:Blinking / Q000502:physiology; D002531:Cerebellum / Q000473:pathology*; D003214:Conditioning, Classical / Q000502:physiology*; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000473:pathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D012021:Reflex, Abnormal / Q000502:physiology