[Biweekly regimen of high dose of leucovorin, 5-fluorouracil, and paclitaxel for patients with advanced gastric cancer].
OBJECTIVE
Clinical study showed that paclitaxel (PTX) may be used to treat gastric cancer. The combination of PTX and 5-fluorouracil (5-FU) is effective, and safe in treating advanced gastric cancer. This study was to investigate efficacy of biweekly regimen of high dose of leucovorin (CF), 5-FU, and PTX on advanced gastric cancer, and its toxicities.


METHODS
Twenty patients with advanced gastric cancer received biweekly regimen of CF/5-FU/PTX (200 mg/m(2) of CF, intravenous infusion for 2 h, day 1; 500 mg/m(2) of 5-FU, intravenous injection, day 1; 1 500 mg/m(2) of 5-FU, intravenous infusion for 46 h, day 1, 2; 90 mg/m(2) of PTX, intravenous infusion for 3 h,day 1). Efficacy, and toxicities were evaluated after 4 cycles.


RESULTS
Total response rate was 65.0% (13/20) with 2 (10.0%) cases of complete remission (CR), and 11 (55.0%) cases of partial remission (PR). No treatment- related death occurred. Stomatitis, hand-foot syndrome, and loss of hair were main toxicities.


CONCLUSIONS
Biweekly regimen of high dose of CF, 5-FU, and PTX may achieve a high response rate with tolerable toxicities in patients with advanced gastric cancer.
Feng
Ji-Feng
JF
Department of Internal Medicine, Jiangsu Provincial Tumor Hospital, Nanjing, Jiangsu 210009, P.R. China. fjif@vip.sina.com
Lu
Jian-Wei
JW
Sun
Xiao-Feng
XF
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013280:Stomatitis / Q000139:chemically induced
D017239:Paclitaxel; D002955:Leucovorin; D005472:Fluorouracil