title: Beneficial effects of weight loss on plasma apolipoproteins in postmenopausal women.
abstract: A total of 39 postmenopausal women 40-70 years of age and undergoing hormone replacement therapy participated in a 6-month weight reduction program, which consisted of a low calorie diet (5040 KJ/day) and phentermine hydrochloride therapy. Subjects had an average body mass index of 35.95+/-5.32 kg/m(2) and 42.20+/-11.0 kg of total fat. Body mass index, plasma lipids, total and trunk fat, and plasma apoproteins were measured at baseline and after 3 and 6 months of the weight reduction program. Subjects experienced an overall 10% weight loss during the treatment period (P<0.001). Plasma LDL cholesterol and triglycerides were reduced by 18% and 15% (P<0.01) respectively, whereas HDL cholesterol was increased by 9% (P<0.01) over the 6-month period. Plasma apoproteins were significantly affected by weight loss. Plasma apolipoprotein (apo) B concentrations were reduced 6.5% (P<0.01), and apo C-III and apo E were reduced by 9% over 6 months (P<0.01). The observed decreases in plasma apo B were significantly correlated with the observed changes in plasma cholesterol (r=0.356, P<0.01) over 3 months. In addition, changes in plasma triglycerides were correlated with changes in both apo C-III (r=0.436) and apo E (r=0.354) over 6 months. These results suggest that weight loss may have multifactorial effects on lipoprotein metabolism, resulting in better plasma lipid and apoprotein profiles.
authors.affiliation: Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Road Ext., Storrs, CT 06268, USA. maria-luz.fernandez@uconn.edu
authors.forename: Maria Luz
authors.initials: ML
authors.lastname: Fernandez
authors.forename: Shiva
authors.initials: S
authors.lastname: Metghalchi
authors.forename: Sonia
authors.initials: S
authors.lastname: Vega-López
authors.forename: Karin
authors.initials: K
authors.lastname: Conde-Knape
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Lohman
authors.forename: Zaida R
authors.initials: ZR
authors.lastname: Cordero-Macintyre
mesh_terms: D000328:Adult; D000368:Aged; D053305:Apolipoprotein C-III; D001053:Apolipoproteins / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood; D001056:Apolipoproteins C / Q000097:blood; D001057:Apolipoproteins E / Q000097:blood; D001067:Appetite Depressants / Q000627:therapeutic use; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004038:Diet, Reducing; D002149:Energy Intake; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010645:Phentermine / Q000627:therapeutic use; D017698:Postmenopause / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D053305:Apolipoprotein C-III; D001053:Apolipoproteins; D001055:Apolipoproteins B; D001056:Apolipoproteins C; D001057:Apolipoproteins E; D001067:Appetite Depressants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D010645:Phentermine