title: Polymorphism of MDR1 gene in healthy japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys).
abstract: We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. Details are as follows. SNP, 020614Honda001; GENE NAME, human P-glycoprotein (MDR1); ACCESSION NUMBER, M29427; LENGTH, 25 bases; 5'-ATGAATCTGGAGG/AAAGACATGACCA-3'. This SNP is expected to cause an amino acid substitution (Glu108Lys). In this study, one homozygote and one heterozygote for G325A were identified.
authors.affiliation: Division of Biopharmaceutics, Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Honda
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Dan
authors.forename: Noriko
authors.initials: N
authors.lastname: Koyabu
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ieiri
authors.forename: Kenji
authors.initials: K
authors.lastname: Otsubo
authors.forename: Shun
authors.initials: S
authors.lastname: Higuchi
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Ohtani
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Sawada