Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient.
A 62-year-old lung transplant recipient had Fusarium proliferatum pneumonia during itraconazole prophylaxis. Severe dyspnea and emphysema ensued, requiring supplemental oxygen therapy. Therapeutic options for this patient were limited; renal insufficiency and cyclosporine use precluded amphotericin B therapy, and susceptibility testing indicated that itraconazole and fluconazole had poor activity against F proliferatum. Treatment with posaconazole, a new triazole in clinical development for the prophylaxis and treatment of fungal infection, resulted in rapid clinical improvement and successful eradication of F proliferatum. Posaconazole may provide effective treatment for difficult-to-treat Fusarium infections.
Herbrecht
Raoul
R
Department of Hematology and Oncology, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, 67098 Strasbourg, France. raoul.herbrecht@chru-strasbourg.fr
Kessler
Romain
R
Kravanja
Christine
C
Meyer
Marie-Hélène
MH
Waller
Jocelyn
J
Letscher-Bru
Valérie
V
D000935:Antifungal Agents / Q000627:therapeutic use*; D005670:Fusarium; D006801:Humans; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000188:drug therapy*; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole