Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus.
A new seven-membered lactone type meroterpenoid, isoterreulactone A, was isolated from the solid state fermentation of Aspergillus terreus and its structure was established by various spectral analysis. Isoterreulactone A inhibited acetylcholinesterase with an IC(50) value of 2.5 microM while did not inhibit butyrylcholinesterase even at 500 microM.
Yoo
Ick-Dong
ID
Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yusong, Taejon 305-600, Korea.
Cho
Kyung-Mi
KM
Lee
Chong-Kil
CK
Kim
Won-Gon
WG
D000110:Acetylcholinesterase / Q000378:metabolism*; D001230:Aspergillus / Q000737:chemistry*; D002091:Butyrylcholinesterase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D005285:Fermentation; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D013729:Terpenes / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D007783:Lactones; D013729:Terpenes; C501341:isoterreulactone A; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase