UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs.
The 5' and 3' untranslated regions of eukaryotic mRNAs play crucial roles in the post-transcriptional regulation of gene expression through the modulation of nucleo-cytoplasmic mRNA transport, translation efficiency, subcellular localization and message stability. UTRdb is a curated database of 5' and 3' untranslated sequences of eukaryotic mRNAs, derived from several sources of primary data. Experimentally validated functional motifs are annotated (and also collated as the UTRsite database) and cross-links to genomic and protein data are provided. The integration of UTRdb with genomic and protein data has allowed the implementation of a powerful retrieval resource for the selection and extraction of UTR subsets based on their genomic coordinates and/or features of the protein encoded by the relevant mRNA (e.g. GO term, PFAM domain, etc.). All internet resources implemented for retrieval and functional analysis of 5' and 3' untranslated regions of eukaryotic mRNAs are accessible at http://www.ba.itb.cnr.it/UTR/.
Mignone
Flavio
F
Dipartimento di Scienze Biomolecolari e Biotecnologie, Università di Milano, via Celoria 26, 20133 Milano, Italy.
Grillo
Giorgio
G
Licciulli
Flavio
F
Iacono
Michele
M
Liuni
Sabino
S
Kersey
Paul J
PJ
Duarte
Jorge
J
Saccone
Cecilia
C
Pesole
Graziano
G
D020413:3' Untranslated Regions / Q000737:chemistry*; D020121:5' Untranslated Regions / Q000737:chemistry*; D001483:Base Sequence; D030561:Databases, Nucleic Acid; D005057:Eukaryotic Cells / Q000378:metabolism; D038621:Regulatory Sequences, Ribonucleic Acid; D018511:Systems Integration
D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D038621:Regulatory Sequences, Ribonucleic Acid