The inhibition of gastric mucosal injury by Punicagranatum L. (pomegranate) methanolic extract.
Administration of 70% methanolic extract of Punicagranatum fruit rind (250 mg/kg and 500 mg/kg) shows a percentage of inhibition in 22.37, 74.21 and 21.95, 63.41 in aspirin- and ethanol-induced gastric ulceration, respectively. In treated groups of animals, the in vivo antioxidant levels such as superoxide dismutase (SOD), catalase, glutathione (GSH) and glutathione peroxidase (GPx) levels were increased and found more or less equal to the normal values. The tissue lipid peroxidation level was found to be decreasing in treated groups of animals as compared to the control group. The histopathological examination of the stomach of the ulcerated animals shows severe erosion of gastric mucosa, sub-mucosal edema and neutrophil infiltration. All of these symptoms were found to be normal in treated groups. In general, the results of the present investigation revealed the gastroprotective activity of the extract through antioxidant mechanism.
Ajaikumar
K B
KB
Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala, India.
Asheef
M
M
Babu
B H
BH
Padikkala
J
J
D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D001241:Aspirin; D000431:Ethanol; D005638:Fruit / Q000737:chemistry; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation; D029561:Lythraceae; D008297:Male; D000432:Methanol; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D011899:Ranitidine / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology
D000897:Anti-Ulcer Agents; D000975:Antioxidants; D010936:Plant Extracts; D000431:Ethanol; D011899:Ranitidine; D001241:Aspirin; D000432:Methanol