title: Determinants of health-related quality of life after aortic valve replacement in six-month survivors of intervention.
abstract: OBJECTIVE
  Although several determinants of survival after aortic valve replacement (AVR) have been identified, current knowledge regarding factors influencing the postoperative quality of life (QoL) is poor. The study aim was to evaluate health-related QoL (using Medical Outcome Study Short Form-36) in six-month survivors after AVR, and to determine predictors of outcome.
  
  
  METHODS
  All patients undergoing heart valve surgery at the authors' hospital between 1992 and May 1999 were included. Data from 201 patients (119 males, 82 females; mean age 66.6 years) after AVR were obtained. The mean observation period was 42.5 months.
  
  
  RESULTS
  Patients in preoperative NYHA classes I and II had a postoperative QoL comparable to that of the general population, while subjects in NYHA classes III and IV scored significantly lower. Multivariate analysis identified four independent predictors (preoperative NYHA class, diabetes mellitus, prosthetic valve type, sternal complications) for the Physical component score. NYHA class, atrial fibrillation, sternal complications and type of valvular heart disease were predictors for the Mental component score. No correlation was found between preoperative left ventricular function or size, pre-existing coronary artery disease or prior myocardial infarction and the postoperative QoL.
  
  
  CONCLUSIONS
  Notably, preoperative aortic stenosis was identified as a strong and independent predictor of the postoperative QoL in six-month survivors after AVR. This effect was independent of left ventricular size and function. These findings support the proposal that patients with aortic stenosis should be operated on at an earlier stage, if possible before they develop symptoms.
authors.affiliation: Medical Clinic II, Cardiology and Angiology, University Hospital Bergmannsheil, Bochum, Germany. henning.baberg@ruhr-uni-bochum.de
authors.forename: Henning T
authors.initials: HT
authors.lastname: Baberg
authors.forename: Matthias
authors.initials: M
authors.lastname: Dirlich
authors.forename: Axel
authors.initials: A
authors.lastname: Laczkovics
authors.forename: Peter
authors.initials: P
authors.lastname: Grewe
authors.forename: Waldemar
authors.initials: W
authors.lastname: Bojara
authors.forename: Justus
authors.initials: J
authors.lastname: de Zeeuw
authors.forename: Torsten T
authors.initials: TT
authors.lastname: Bauer
authors.forename: Joachim
authors.initials: J
authors.lastname: Kugler
authors.forename: Andreas
authors.initials: A
authors.lastname: Mügge
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006349:Heart Valve Diseases / Q000503:physiopathology / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology / Q000601:surgery*; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology; D011788:Quality of Life; D012720:Severity of Illness Index; D013318:Stroke Volume; D016896:Treatment Outcome; D016277:Ventricular Function, Left