title: Pathways of tau fibrillization.
abstract: New methods for analyzing tau fibrillization have yielded insights into the biochemical transitions involved in the process. Here we review the parallels between the sequential progression of tau fibrillization observed macroscopically in Alzheimer's disease (AD) lesions and the pathway of tau aggregation observed in vitro with purified tau preparations. In addition, pharmacological agents for further dissection of fibrillization mechanism and lesion formation are discussed.
authors.affiliation: Center for Molecular Neurobiology, Department of Molecular and Cellular Biochemistry, Ohio St. University College of Medicine and Public Health, 1060 Carmack Rd., Columbus, OH 43210, USA. kuret.3@osu.edu
authors.forename: Jeff
authors.initials: J
authors.lastname: Kuret
authors.forename: Carmen N
authors.initials: CN
authors.lastname: Chirita
authors.forename: Erin E
authors.initials: EE
authors.lastname: Congdon
authors.forename: Theresa
authors.initials: T
authors.lastname: Kannanayakal
authors.forename: Guibin
authors.initials: G
authors.lastname: Li
authors.forename: Mihaela
authors.initials: M
authors.lastname: Necula
authors.forename: Haishan
authors.initials: H
authors.lastname: Yin
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhong
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism; D001923:Brain Chemistry; D066298:In Vitro Techniques; D008869:Microtubule-Associated Proteins / Q000235:genetics; D008954:Models, Biological; D009154:Mutation; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D010766:Phosphorylation; D020033:Protein Isoforms; D011994:Recombinant Proteins; D016875:tau Proteins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; C054369:MAPT protein, human; D008869:Microtubule-Associated Proteins; D020033:Protein Isoforms; D011994:Recombinant Proteins; D016875:tau Proteins