The multiple feedback loop hypothesis of chronic diseases.
The body uses multiple feedback loops to regulate the storage and retrieval of critical substances to maintain homeostasis. In the presence of a deficiency of some required constituents, this system will extract the required constituent from tissue storage. If this deficiency persists, after an extended period of time, the extraction depletes the stores of a constituent in the cells rendering the various cellular pumps ineffective in further extraction. When this happens, the endocrine system releases hormones instructing the immune system to assist in the extraction process. This results in inflammation and cumulative cellular damage. When there is a large quantity of tissue available the individual cellular damage will be less severe, but the total cumulative effect can still be significant to the point of being incapacitating. This cumulative cellular damage is the chronic disease like arthritis. Because of limited quantities of a tissue type, like myelin, the cumulative cellular damage can progress to such an extent that the immune system can no longer recognize the individual cells, which initiates an immune system response.
Pyle
Donald
D
Boeing, 312 N. Milstead, Wichita, KS 67212, USA. don.pyle@boeing.com
D000311:Adrenal Glands / Q000502:physiology; D002908:Chronic Disease; D015444:Exercise / Q000502:physiology; D025461:Feedback, Physiological / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D006963:Hyperphagia / Q000503:physiopathology; D007109:Immunity / Q000502:physiology*; D013256:Steroids / Q000502:physiology
D013256:Steroids