title: [Killer immunoglobulin-like receptor gene distribution in Guangdong Han population].
abstract: OBJECTIVE
  To investigate the distribution of killer immunoglobulin-like receptor (KIR) gene in Guangdong Han population.
  
  
  METHODS
  KIR phenotype was examined by PCR with sequence-specific primers in 96 subjects of Han nationality in Guangdong Province of China, and KIR frequency was calculated and compared with those in Caucasian, north Indian and Japanese populations.
  
  
  RESULTS
  The gene expression frequency of KIR in Guangdong Han people was 2DL1(0.85), 2DL2(0.12), 2DL3(0.58), 2DL4(1), 2DL5(0.24), 3DL1(0.96), 3DL2(1), 3DL3(1), 2DP1(0.97), 2DP2(0.98), 2DS1(0.10), 2DS2(0.30), 2DS3(0.02), 2DS4(0.28), 1D(0.65), 2DS5(0.19), and 3DS1(0.23) respectively. Comparison of the KIR recognizing the same HLA ligand suggested significantly higher expression frequency of inhibitory KIR than that of activating KIR. Compared with Caucasian and north Indian populations, Guangdong Han population had significantly lower expression frequency of activating KIR gene with the exception of KIR2DS4.
  
  
  CONCLUSIONS
  Different KIR genes have different expression frequencies in Guangdong Han population, and KIR gene distribution varies between populations of different races.
authors.affiliation: Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. yin-xl@163.com
authors.forename: Xiao-lin
authors.initials: XL
authors.lastname: Yin
authors.forename: Kun-yuan
authors.initials: KY
authors.lastname: Guo
authors.forename: Hong-jing
authors.initials: HJ
authors.lastname: Ma
authors.forename: Zheng-chuan
authors.initials: ZC
authors.lastname: Shang
authors.forename: Lu-lu
authors.initials: LL
authors.lastname: Xiao
authors.forename: Xin
authors.initials: X
authors.lastname: Ye
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000328:Adult; D002681:China / Q000208:ethnology; D005787:Gene Frequency; D006680:HLA Antigens / Q000378:metabolism; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000235:genetics*; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054344:Receptors, KIR2DL3; D054345:Receptors, KIR2DL4; D054341:Receptors, KIR3DL1; D054347:Receptors, KIR3DL2; D054349:Receptors, KIR3DS1
chemical_list: D006680:HLA Antigens; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054342:Receptors, KIR2DL1; D054344:Receptors, KIR2DL3; D054345:Receptors, KIR2DL4; D054341:Receptors, KIR3DL1; D054347:Receptors, KIR3DL2; D054349:Receptors, KIR3DS1