title: Effect of cardiac resynchronization therapy on global and regional oxygen consumption and myocardial blood flow in patients with non-ischaemic and ischaemic cardiomyopathy.
abstract: OBJECTIVE
  We studied the effects of cardiac resynchronization therapy (CRT) on global and regional myocardial oxygen consumption (MVO2) and myocardial blood flow (MBF) in non-ischaemic (NICM) and ischaemic dilated cardiomyopathy (ICM).
  
  
  RESULTS
  Thirty-one NICM and 11 ICM patients, all of them acute responders, were investigated. MVO2 and MBF were obtained by 11C-acetate PET before and after 4 months of CRT. In NICM global MVO2 and MBF did not change during CRT, while the rate pressure product (RPP) normalized MVO2 increased (P=0.03). Before CRT regional MVO2 and MBF were highest in the lateral wall and lowest in the septum. Under therapy, MVO2 and MBF decreased in the lateral wall (P=0.045) and increased in the septum (P=0.045) resulting in a more uniform distribution. In ICM, global MVO2, MBF, and RPP did not change under CRT. Regional MVO2 and MBF showed no significant changes but a similar tendency in the lateral and septal wall to that in NICM.
  
  
  CONCLUSIONS
  CRT induces changes of MVO2 and MBF on a regional level with a more uniform distribution between the myocardial walls and improved ventricular efficiency in NICM. Based on the investigated parameters, CRT appears to be more effective in NICM than in ICM.
authors.affiliation: Institute of Molecular Biophysics, Radiopharmacy, and Nuclear Medicine, Heart and Diabetes Center North Rhine-Westphalia, Georgstr. 11, D-32545 Bad Oeynhausen, Germany. olindner@hdz-nrw.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Lindner
authors.forename: Jürgen
authors.initials: J
authors.lastname: Vogt
authors.forename: Annett
authors.initials: A
authors.lastname: Kammeier
authors.forename: Peter
authors.initials: P
authors.lastname: Wielepp
authors.forename: Jens
authors.initials: J
authors.lastname: Holzinger
authors.forename: Detlev
authors.initials: D
authors.lastname: Baller
authors.forename: Barbara
authors.initials: B
authors.lastname: Lamp
authors.forename: Bert
authors.initials: B
authors.lastname: Hansky
authors.forename: Reiner
authors.initials: R
authors.lastname: Körfer
authors.forename: Dieter
authors.initials: D
authors.lastname: Horstkotte
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Burchert
mesh_terms: D000704:Analysis of Variance; D001794:Blood Pressure / Q000502:physiology; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D002311:Cardiomyopathy, Dilated / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D003326:Coronary Circulation / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D010101:Oxygen Consumption / Q000502:physiology*; D049268:Positron-Emission Tomography