Cytokines and soluble tumour necrosis factor I receptor levels during pretransplant conditioning in allogeneic stem-cell transplantation.
The inflammatory response induced by the conditioning regime may be related to the outcome in allogeneic stem-cell transplantation (SCT). However, previous statements concerning the prognostic significance of cytokine measurements during conditioning have not been conclusive. We investigated a broad range of cytokines in plasma samples drawn daily immediately before start of pretransplant conditioning and during the conditioning. The presented data indicate that single-day measurements of inflammatory cytokines during conditioning may lead to unreliable conclusions concerning their prognostic significance. However, serial quantitation of soluble tumour necrosis factor receptor I (sTNFRI) is more likely to reflect the degree of inflammatory activation induced by pretransplant conditioning.
Andersen
Johnny
J
Institute for Inflammation Research, The National University Hospital Rigshospitalet, Copenhagen, Denmark.
Heilmann
Carsten
C
Jacobsen
Niels
N
Bendtzen
Klaus
K
Müller
Klaus
K
D000328:Adult; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D002648:Child; D016207:Cytokines / Q000096:biosynthesis / Q000097:blood*; D003718:Denmark; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D007951:Leukemia, Myeloid / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011379:Prognosis; D017472:Receptors, Interleukin-1 / Q000096:biosynthesis; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000032:analysis* / Q000096:biosynthesis; D013997:Time Factors; D014916:Whole-Body Irradiation
D000961:Antilymphocyte Serum; D016207:Cytokines; D017472:Receptors, Interleukin-1; D047888:Receptors, Tumor Necrosis Factor, Type I