Clinical consequences of antiphospholipid antibodies.
Antiphospholipid antibodies (aPL), notably the lupus anticoagulant and anticardiolipin antibodies, are the serological hallmarks of the antiphospholipid syndrome. Thrombosis and pregnancy complications are the most prominent clinical manifestations of this syndrome. This paper provides the clinician with guidelines for ordering and interpreting tests for aPL and discusses consequences for treatment if persistently positive tests are found.
Derksen
R H W M
RH
Department of Rheumatology and Clinical Immunology, Room F02.127, University Medical Centre, Heidelberglaan 100, 3584 GA Utrecht, The Netherlands. r.h.w.m.derksen@digd.azu.nl
de Groot
P G
PG
D017153:Antibodies, Anticardiolipin / Q000097:blood* / Q000276:immunology; D017152:Antibodies, Antiphospholipid / Q000097:blood* / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D019411:Clinical Laboratory Techniques; D005260:Female; D006403:Hematologic Tests; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood* / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000209:etiology; D013927:Thrombosis / Q000209:etiology
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor