title: Ecological effects of perorally administered pivmecillinam on the normal vaginal microflora.
abstract: The knowledge of the effects of antimicrobial agents on the normal vaginal microflora is limited. The objective of the present study was to study the ecological impact of pivmecillinam on the normal vaginal microflora. In 20 healthy women, the estimated day of ovulation was determined during three subsequent menstrual cycles. Microbiological and clinical examinations were performed on the estimated day of ovulation and on day 3 in all cycles and also on day 7 after ovulation in cycles 1 and 2. Anaerobic and facultative anaerobic gram-positive rods, mainly species of lactobacilli and actinomycetes, dominated the microflora. One woman was colonized on the third day of administration with a resistant Escherichia coli strain, and Candida albicans was detected in one woman on days 3 and 7 in cycle 2. No other major changes in the normal microflora occurred during the study. Administration of pivmecillinam had a minor ecological impact on the normal vaginal microflora.
authors.affiliation: Division of Clinical Bacteriology, F82, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden.
authors.forename: Asa
authors.initials: A
authors.lastname: Sullivan
authors.forename: Aino
authors.initials: A
authors.lastname: Fianu-Jonasson
authors.forename: Britt-Marie
authors.initials: BM
authors.lastname: Landgren
authors.forename: Carl Erik
authors.initials: CE
authors.lastname: Nord
mesh_terms: D039903:Actinobacteria / Q000187:drug effects / Q000254:growth & development; D000284:Administration, Oral; D000328:Adult; D000561:Amdinocillin Pivoxil / Q000008:administration & dosage / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects / Q000254:growth & development; D001421:Bacteria, Anaerobic / Q000187:drug effects / Q000254:growth & development; D017753:Ecosystem; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects / Q000254:growth & development; D008598:Menstruation; D014621:Vagina / Q000187:drug effects / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D000561:Amdinocillin Pivoxil