Prediction of heart transplant rejection with a breath test for markers of oxidative stress.
The Heart Allograft Rejection: Detection with Breath Alkanes in Low Levels study evaluated a breath test for oxidative stress in heart transplant recipients, and we report here a mathematical model predicting the probability of grade 3 rejection. The breath test divided the heart transplant recipients into 3 groups: positive for grade 3 rejection, negative for grade 3 rejection, and intermediate. The test was 100% sensitive for grade 3 heart transplant rejection when the p value was >/=0.98, and 100% specific when the p value was </=0.058; in the intermediate group, the breath test determined the probability of grade 3 rejection and the predictive value of the result.
Phillips
Michael
M
Menssana Research Inc., Fort Lee, New Jersey, USA. mphilips@menssanaresearch.com
Boehmer
John P
JP
Cataneo
Renee N
RN
Cheema
Taseer
T
Eisen
Howard J
HJ
Fallon
John T
JT
Fisher
Peter E
PE
Gass
Alan
A
Greenberg
Joel
J
Kobashigawa
Jon
J
Mancini
Donna
D
Rayburn
Barry
B
Zucker
Mark J
MJ
D000473:Alkanes / Q000032:analysis; D001944:Breath Tests; D006084:Graft Rejection / Q000175:diagnosis*; D016027:Heart Transplantation; D006801:Humans; D008433:Mathematics; D008962:Models, Theoretical; D018384:Oxidative Stress / Q000502:physiology*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity
D000473:Alkanes