title: Unrelated cord blood transplantation with a reduced-intensity conditioning regimen following autologous transplantation for multiple myeloma.
abstract: Two patients, 51- and 45-year-old men with stage III immunoglobulin G multiple myeloma, achieved partial and complete remissions, respectively, after conventional chemotherapy. They both received high-dose melphalan (200 mg/m2) with autologous stem cell transplantation (ASCT). Eighty-four and 78 days after ASCT, the patients underwent unrelated cord blood transplantation (CBT) following treatment with total-body irradiation (2 Gy), fludarabine (90 mg/m2), and melphalan (140 mg/m2). Neutrophil engraftment was attained on day +27 in patient 1 and day +15 in patient 2. Full donor chimerism of the marrow cells was confirmed. Regimen-related toxicity in both patients remained within grade I. Grades I and II acute graft-versus-host disease (GVHD) occurred in patients I and 2, respectively, but improved without steroid therapy. Both patients developed limited chronic GVHD of the skin but needed no treatment. The serum paraprotein level in patient 1 decreased further after ASCT and CBT but remained at minimally detectable levels. The serum and urine paraprotein levels in patient 2 remained below detectable limits. These results suggested that CBT with a reduced-intensity conditioning regimen after high-dose chemotherapy with ASCT is a new promising approach for the treatment of multiple myeloma.
authors.affiliation: Department of Hematology/Oncology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yamada
authors.forename: Akira
authors.initials: A
authors.lastname: Tomonari
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Jun
authors.initials: J
authors.lastname: Ooi
authors.forename: Tohru
authors.initials: T
authors.lastname: Iseki
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shimohakamada
authors.forename: Kashiya
authors.initials: K
authors.lastname: Takasugi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ohno
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Nagamura
authors.forename: Kaoru
authors.initials: K
authors.lastname: Uchimaru
authors.forename: Arinobu
authors.initials: A
authors.lastname: Tojo
authors.forename: Hisataka
authors.initials: H
authors.lastname: Moriwaki
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Asano
mesh_terms: D036101:Cord Blood Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy*; D019172:Transplantation Conditioning / Q000379:methods*; D014182:Transplantation, Autologous