title: Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter.
abstract: Major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (SLC6A4). During the presentation of aversive, but not pleasant, pictures, healthy carriers of the SLC6A4 short (s) allele showed stronger activation of the amygdala on functional magnetic resonance imaging. s carriers also showed greater coupling between the amygdala and the ventromedial prefrontal cortex, which may contribute to the abnormally high activity in the amygdala and medial prefrontal cortex seen in major depression.
authors.affiliation: Department of Psychiatry, Charité University Medicine Berlin, Campus Charité Mitte, Schumannstr. 20-21, 10117 Berlin, Germany. andreas.heinze@charite.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinz
authors.forename: Dieter F
authors.initials: DF
authors.lastname: Braus
authors.forename: Michael N
authors.initials: MN
authors.lastname: Smolka
authors.forename: Jana
authors.initials: J
authors.lastname: Wrase
authors.forename: Imke
authors.initials: I
authors.lastname: Puls
authors.forename: Derik
authors.initials: D
authors.lastname: Hermann
authors.forename: Sabine
authors.initials: S
authors.lastname: Klein
authors.forename: Sabine M
authors.initials: SM
authors.lastname: Grüsser
authors.forename: Herta
authors.initials: H
authors.lastname: Flor
authors.forename: Gunter
authors.initials: G
authors.lastname: Schumann
authors.forename: Karl
authors.initials: K
authors.lastname: Mann
authors.forename: Christian
authors.initials: C
authors.lastname: Büchel
mesh_terms: D000368:Aged; D000483:Alleles; D000679:Amygdala / Q000098:blood supply / Q000502:physiology*; D004644:Emotions; D006579:Heterozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000502:physiology*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000098:blood supply / Q000502:physiology*; D050486:Serotonin Plasma Membrane Transport Proteins
chemical_list: D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D010100:Oxygen