[Experimental study on hemostatic effect of flos sophorae and its extracts].
OBJECTIVE
To compare the hemostatic effect of Flos Sophorae in crude, parched and carbonized forms and its extracts, including rutin, quercetin and tannin.


METHODS
All the testing samples were orally administered to the experimental animals for 5 days, then the bleeding time (BT), coagulation time (CT), platelet count and capillary permeability (CP) in the treated mice were tested, and the prothrombin time (PT), fibrinogen (FBG) content and platelet aggregation rate (PAR) in the treated rats were determined.


RESULTS
All the samples could lower the CP, BT and CT in mice and also decrease the plasma PT in rats. All three forms of Flos Sophorae could increase FBG in rats, while the three extracts of it could inhibit the PAR in rats obviously. In addition, rutin had the effect of raising the platelet count.


CONCLUSIONS
All the three forms and three extracts of Flos Sophorae have hemostatic effect, the effect of parched and carbonized form is higher than that of crude drug. The mechanism of the hemostatic effect of the six kinds of sample might be various.
Li
Hui
H
Institute of Chinese Materia Medica, China Academy of TCM, Beijing (100700). annasohou@hotmail.com
Yuan
Gui-dong
GD
Jin
Ya-hong
YH
Li
Raorao
R
Wang
Lan
L
Wang
Sufen
S
D000818:Animals; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D035264:Flowers / Q000737:chemistry; D006490:Hemostatics / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011794:Quercetin / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012431:Rutin / Q000302:isolation & purification / Q000494:pharmacology; D029909:Sophora / Q000737:chemistry; D013634:Tannins / Q000302:isolation & purification / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D006490:Hemostatics; D013634:Tannins; D012431:Rutin; D011794:Quercetin