Acral necrosis after inadequate excessive administration of bleomycin in a testicular cancer patient.
BACKGROUND
Testicular cancer has a favorable prognosis in the majority of patients due to the excellent susceptibility to chemotherapy with cisplatin, etoposide and bleomycin (BEP), which is commonly administered over 3-4 cycles of treatment.


METHODS
A 22-year-old male failed to achieve complete response after unconventional treatment with 6 courses of BEP for intermediate-risk metastasized testicular cancer. The patient developed chemotherapy-induced digital necrosis and substantial loss of digital function after this excessive treatment. This condition resolved with infusional alprostadil combined with oral clonidin and pentoxifyllin.


RESULTS
Infusional alprostadil adds substantial clinical benefit to combined vasoactive therapy in chemotherapy-induced vascular toxicity, even after the onset of digital necrosis.
Grünwald
Viktor
V
Abteilung für Hämatologie, Hämostaseologie und Onkologie, Medizinische Hochschule Hannover, Germany. Gruenwald.Viktor@mh-hannover.de
Bolte
Oliver
O
Wiebe
Stefanie
S
Ganser
Arnold
A
Schöffski
Patrick
P
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D001761:Bleomycin / Q000008:administration & dosage* / Q000009:adverse effects*; D003000:Clonidine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005385:Fingers / Q000473:pathology*; D006801:Humans; D008297:Male; D009257:Nafronyl / Q000008:administration & dosage; D009336:Necrosis / Q000139:chemically induced / Q000188:drug therapy; D011928:Raynaud Disease / Q000188:drug therapy* / Q000209:etiology*; D013736:Testicular Neoplasms / Q000188:drug therapy*; D017211:Treatment Failure; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
D000970:Antineoplastic Agents; D014665:Vasodilator Agents; D001761:Bleomycin; D009257:Nafronyl; D003000:Clonidine