[Membranous nephropathy following allogeneic peripheral blood stem cell transplantation in a boy with anaplastic large cell lymphoma].
We report the case of 13-year-old boy who had been diagnosed as having anaplastic large cell lymphoma (ALCL) when he was 11 years old. He suffered a relapse despite the chemotherapy regimens he had been subjected to. Since anaplastic lymphoma kinase (ALK), one of the important prognostic factors of ALCL, was not expressed in the tumor cells, allogeneic peripheral blood stem cell transplantation (PBSCT) from his HLA-matched elder brother was performed. Eleven months after PBSCT, the patient developed nephrotic syndrome as a consequence of chronic graft-versus-host disease (GVHD). He was diagnosed as having membranous nephropathy (MN) based on the results of histological examinations. Soluble interleukin-2 receptor and anti-nuclear antibody closely reflected the clinical course of MN, therefore some immune mechanisms closely related to chronic GVHD seemed to contribute to the occurrence of MN after PBSCT.
Park
Young-Dong
YD
Department of Pediatrics, Nara Medical University.
Hamada
Masaaki
M
Higuchi
Banryoku
B
Kishimoto
Tomoko
T
Inagaki
Jiro
J
Nishiguchi
Masayuki
M
Shimoyama
Hironobu
H
Nakajima
Mitsuru
M
Nakagawa
Atsuko
A
Yoshioka
Akira
A
D000293:Adolescent; D015433:Glomerulonephritis, Membranous / Q000209:etiology*; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000628:therapy*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous