Rupture of the gallbladder in a patient with acquired factor VIII inhibitors and systemic lupus erythematosus.
A 54-year-old woman with a 21-year history of systemic lupus erythematosus (SLE) was admitted to the Matsuyama Red Cross Hospital due to subcutaneous and gingival hemorrhaging. She was diagnosed with acquired factor VIII inhibitors based on a prolonged activated partial-thromboplastin time (APTT) and factor VIII inhibitors. Steroid pulse and factor VIII plasma concentrate were administered to her, not long after which she was transferred to Ehime University Hospital due to gallbladder hematoma. Although her APTT and factor VIII activity were improved after treatment with human factor VIII, she died of multiple organ failure. The autopsy demonstrated a ruptured gallbladder.
Onishi
Sachiko
S
First Department of Internal Medicine, Ehime University Hospital, Ehime.
Hojo
Nobumasa
N
Sakai
Ikuya
I
Yasukawa
Masaki
M
Hato
Takaaki
T
Minamoto
Youko
Y
Yokota
Eisuke
E
Ito
Mitsuko R
MR
Dote
Kentaro
K
Shimizu
Ichiro
I
Nakanishi
Kazuo
K
Fujita
Shigeru
S
D001323:Autoantibodies / Q000097:blood; D001774:Blood Chemical Analysis; D001780:Blood Coagulation Tests; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D017809:Fatal Outcome; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000473:pathology; D005705:Gallbladder Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000401:mortality; D006467:Hemophilia A / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008875:Middle Aged; D012422:Rupture, Spontaneous; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D001323:Autoantibodies; D005169:Factor VIII