[Clinical observation on effect of xuefu zhuyu decoction in treating patients with liver fibrosis caused by chronic hepatitis B].
OBJECTIVE
To observe the effect of Xuefu Zhuyu decoction (XZD) on the chronic hepatitis B caused liver fibrosis (CHBLF) and the portal hemodynamics.


METHODS
Sixty patients with CHBLF were randomly divided into two groups, the 28 patients in the treated group were treated with oral intake of XZD and conventional liver protective treatment, the 32 patients in the control group were treated with conventional liver protective treatment alone, the therapeutic course for both groups was 3 months. Serum liver fibrosis criteria and portal dynamical criteria were observed before and after treatment.


RESULTS
Comparison of the remarkable effective rate between the two groups showed significant difference. After treatment, in the treated group, all the serum criteria for liver fibrosis (HA, PCIII, LN) and criteria for portal trunk hemodynamics, such as mean velocity and quantity of blood flow were significantly improved (P < 0.05 or P < 0.01), as compared with those in the control group, the difference was also significant (P < 0.05 or P < 0.01).


CONCLUSIONS
XZD has definite therapeutic effect on chronic hepatitis B caused liver fibrosis.
Ru
Qing-jing
QJ
Xinhua Hospital Affiliated to Zhejiang TCM College, Hangzhou. cshru@163.com
Tang
Zhi-min
ZM
Zhang
Zhen-e
ZE
Zhu
Qigui
Q
D000293:Adolescent; D000328:Adult; D024061:Collagen Type III / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011169:Portal Vein / Q000503:physiopathology
D024061:Collagen Type III; D004365:Drugs, Chinese Herbal; D006820:Hyaluronic Acid