[Assessment of soluble intracellular adhesion molecule-1 (sICAM-1) in women with benign ovarian tumors].
OBJECTIVE
Overexpression of intracellular adhesion molecule-I (ICAM-1) was observed in many benign and malignant tumors. The aim of our study was to evaluate its serum concentrations as well as CA-125 in women with benign ovarian tumors.


METHODS
Forty-five women treated surgically because of benign ovarian mass.


RESULTS
Mean concentrations of sICAM-1 in benign tumors was 241.8+/-74.1 ng/ml and 195.6+/-68.7 ng/ml in healthy controls. No correlations between sICAM-1 concentrations and leukocyte count, tumor volume, BMI and obstetrical history. Efficiency in tumor differentiation was higher for CA-125 than sICAM-1 (area under Receiver Operating Characteristic curve 0.78 and 0.63 respectively). We observed higher sICAM-1 concentrations in fibrothecomas and lower in endometrial and dermoid cysts.


CONCLUSIONS
Serum ICAM-1 concentrations correlate with some histological types of benign tumors, but not with tumor volume. Levels of CA-125 are more effective than ICAM-1 in ovarian tumors differentiation.
Rzymski
Paweł
P
Klinika Zdrowia Matki i Dziecka AM w Poznaniu, Poznań. parzymsk@gpsk.am.poznan.pl
Opala
Tomasz
T
Woźniak
Jakub
J
Drews
Krzysztof
K
Sajdak
Stefan
S
D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D009367:Neoplasm Staging; D010048:Ovarian Cysts / Q000276:immunology; D010049:Ovarian Diseases / Q000276:immunology; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000601:surgery; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013997:Time Factors
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018799:Intercellular Adhesion Molecule-1