title: Modular synthesis of pantetheine and phosphopantetheine.
abstract: [structure: see text] D-Pantetheine and D-phosphopantetheine, precursors to coenzyme A, have been synthesized though a linear sequence from three modules (M1-M3) in 9 and 10 steps, respectively. These routes provide access to analogues of coenzyme A containing modified cystamines, beta-alanines, and pantoic acid residues. All three modules were joined using conventional methods of peptide synthesis. The chiral component, M3, was derived from D-pantolactone.
authors.affiliation: Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Mandel
authors.forename: James J
authors.initials: JJ
authors.lastname: La Clair
authors.forename: Michael D
authors.initials: MD
authors.lastname: Burkart
mesh_terms: D015394:Molecular Structure; D010204:Pantetheine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010204:Pantetheine; C003129:4'-phosphopantetheine