[Study of serum levels of interlukin-2 and its receptor, interlukin-6, sICAM-1, sVCAM-1 in patients with recurrent genital herpes].
OBJECTIVE
To study cellular immunity status and serum levels of adhesion molecules of patients with recurrent genital herpes.


METHODS
Serum levels of interlukin-2 and its soluble receptor, interlukin-6, sICAM-1, sVCAM-1 were measured by ELISA in 34 patients with recurrent genital herpes.


RESULTS
The serum levels of IL-2 and IL-6 were significantly lower in patients than in healthy controls (P < 0.01). The levels of sIL-2R, sICAM-1 and sVCAM-1 were significantly higher in patients than in controls (P < 0.05). No significant differences were seen in all variables of patients in relapse phase and remission phase (P > 0.05).


CONCLUSIONS
There are cellular immunity deficiency and high serum levels of adhesion molecules in patients with recurrent genital herpes, and these changes may be related to therecurrence of genital herpes and the development of inflammatory reaction.
Zhang
Min
M
Department of Dermatovenerology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhang
Yizhi
Y
D000328:Adult; D005260:Female; D006558:Herpes Genitalis / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood; D012008:Recurrence; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D007376:Interleukin-2; D015850:Interleukin-6; D015375:Receptors, Interleukin-2; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1