Towards a splicing code.
A combination of experimental and bioinformatics approaches leads Burge and colleagues (Wang et al., 2004 [this issue of Cell]) to a global view of how an RNA segment may be selected or avoided in mature mRNAs due to biased distributions of exonic enhancers and silencers, a process vital for genome evolution, developmental control, and disease onset.
Fu
Xiang-Dong
XD
Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
D000465:Algorithms; D000818:Animals; D016000:Cluster Analysis; D003198:Computer Simulation; D005091:Exons / Q000235:genetics; D015723:Gene Library; D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B / Q000235:genetics; D034541:Heterogeneous-Nuclear Ribonucleoprotein Group F-H / Q000235:genetics; D006801:Humans; D012326:RNA Splicing / Q000235:genetics* / Q000502:physiology; D038621:Regulatory Sequences, Ribonucleic Acid / Q000235:genetics*; D037941:Silencer Elements, Transcriptional / Q000235:genetics*
D000076245:Heterogeneous Nuclear Ribonucleoprotein A1; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D034541:Heterogeneous-Nuclear Ribonucleoprotein Group F-H; D038621:Regulatory Sequences, Ribonucleic Acid