title: Label free colorimetric biosensing using nanoparticles.
abstract: In this review article, we discuss a class of biosensors that exploit the change in the colorimetric properties of noble metal nanoparticles in response to biomolecular binding at their surface. Several sensor fabrication techniques as well as sensor configurations are discussed with an emphasis on their strengths and limitations. We conclude by presenting the future prospects and challenges for the successful transition of this technology from the laboratory to a commercial product.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Nath
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Chilkoti
mesh_terms: D000465:Algorithms; D015374:Biosensing Techniques / Q000379:methods* / Q000639:trends; D003124:Colorimetry; D006046:Gold / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D046208:Microchip Analytical Procedures / Q000379:methods; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D010316:Particle Size; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism; D012834:Silver / Q000737:chemistry; D013053:Spectrophotometry; D020349:Surface Plasmon Resonance
chemical_list: D011506:Proteins; D012834:Silver; D006046:Gold