title: [Effects of catalase on the mitochondria and apoptosis of SW480 cells].
abstract: OBJECTIVE
  To investigate the effects of catalase on the mitochondria and apoptotic behavior of SW480 cells treated by lipopolysaccharide (LPS), and the changes in intracellular expression of nuclear factor kappaB (NF-kappaB).
  
  
  METHODS
  LPS-stimulated SW480 cells were treated with catalase and the changes in their mitochondria and apoptotic behavior were observed by transmission electron microscopy. The expression of NF-kappaB was detected by immunohistochemical method.
  
  
  RESULTS
  Mitochondria damages and apoptosis were slightly diminished in the LPS-stimulated cells with catalase pretreatment, and the NF-kappaB expression was also decreased.
  
  
  CONCLUSIONS
  Catalase protect the mitochondria of SW480 cells from damages by LPS and inhibit the cell apoptosis, possibly due to the activation of NF-kappaB.
authors.affiliation: Institute for Digestive Diseases of PLA, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. captainwl@163.com
authors.forename: Qun-ying
authors.initials: QY
authors.lastname: Wang
authors.forename: Ji-de
authors.initials: JD
authors.lastname: Wang
authors.forename: Shi-shun
authors.initials: SS
authors.lastname: Zhong
authors.forename: Ya-dong
authors.initials: YD
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.forename: Liang-ren
authors.initials: LR
authors.lastname: Li
authors.forename: Ya-li
authors.initials: YL
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002374:Catalase / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008070:Lipopolysaccharides; D008928:Mitochondria / Q000378:metabolism*; D016328:NF-kappa B / Q000096:biosynthesis / Q000235:genetics
chemical_list: D008070:Lipopolysaccharides; D016328:NF-kappa B; D002374:Catalase