Molecular determinants of the structural and functional organization of the sarcoplasmic reticulum.
The endo-sarcoplasmic reticulum of striated muscle cells consists of distinct functional domains that are extremely well organized both in terms of functional specialisation and of spatial organisation. Here we shall review recent evidence on the potential involvement of recently identified novel proteins and of cytoskeletal components in the structural and functional organization of the sarcoplasmic reticulum with respect to the surface membrane/T-tubule system and the contractile apparatus.
Sorrentino
Vincenzo
V
Molecular Medicine Section, Department of Neuroscience, University of Siena, via Aldo Moro 5, 53100, Italy. v.sorrentino@unisi.it
D000818:Animals; D017487:Ankyrins / Q000378:metabolism; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism / Q000648:ultrastructure; D020033:Protein Isoforms / Q000378:metabolism; D012519:Sarcoplasmic Reticulum / Q000737:chemistry* / Q000502:physiology*
D017487:Ankyrins; D020033:Protein Isoforms