title: Statistical analysis of monotone or non-monotone dose-response data from in vitro toxicological assays.
abstract: Various tests on trend in toxicological studies are reviewed, and the advantages and the disadvantages involved with such procedures are discussed. New tests are introduced to overcome difficulties common to many current procedures, such as downturns at higher doses, and missing numerical availability.
authors.affiliation: Bioinformatics Unit, University of Hannover, 30419 Hannover, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Bretz
authors.forename: Ludwig A
authors.initials: LA
authors.lastname: Hothorn
mesh_terms: D000826:Animal Testing Alternatives / Q000379:methods / Q000706:statistics & numerical data; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D015233:Models, Statistical; D009153:Mutagens / Q000145:classification / Q000633:toxicity; D015203:Reproducibility of Results; D018675:Toxicity Tests / Q000379:methods* / Q000706:statistics & numerical data*
chemical_list: D009153:Mutagens