title: The Ca2+/Mn2+ pumps in the Golgi apparatus.
abstract: Recent evidence highlights the functional importance of the Golgi apparatus as an agonist-sensitive intracellular Ca(2+) store. Besides Ca(2+)-release channels and Ca(2+)-binding proteins, the Golgi complex contains Ca(2+)-uptake mechanisms consisting of the well-known sarco/endoplasmic reticulum Ca(2+)-transport ATPases (SERCA) and the much less characterized secretory-pathway Ca(2+)-transport ATPases (SPCA). SPCA supplies the Golgi compartments and, possibly, the more distal compartments of the secretory pathway with both Ca(2+) and Mn(2+) and, therefore, plays an important role in the cytosolic and intra-Golgi Ca(2+) and Mn(2+) homeostasis. Mutations in the human gene encoding the SPCA1 pump (ATP2C1) resulting in Hailey-Hailey disease, an autosomal dominant skin disorder, are discussed.
authors.affiliation: Laboratorium voor Fysiologie, K.U. Leuven Campus Gasthuisberg O/N, Herestraat 49, B-3000, Leuven, Belgium.
authors.forename: Kurt
authors.initials: K
authors.lastname: Van Baelen
authors.forename: Leonard
authors.initials: L
authors.lastname: Dode
authors.forename: Jo
authors.initials: J
authors.lastname: Vanoevelen
authors.forename: Geert
authors.initials: G
authors.lastname: Callewaert
authors.forename: Humbert
authors.initials: H
authors.lastname: De Smedt
authors.forename: Ludwig
authors.initials: L
authors.lastname: Missiaen
authors.forename: Jan B
authors.initials: JB
authors.lastname: Parys
authors.forename: Luc
authors.initials: L
authors.lastname: Raeymaekers
authors.forename: Frank
authors.initials: F
authors.lastname: Wuytack
mesh_terms: D000252:Calcium-Transporting ATPases / Q000737:chemistry / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D008345:Manganese / Q000737:chemistry / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D016506:Pemphigus, Benign Familial / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D026901:Membrane Transport Proteins; D008345:Manganese; D000252:Calcium-Transporting ATPases