Expression of adhesion molecules on peripheral lymphocytes predicts future lesion development in MS.
The expression of adhesion molecules (alpha4beta1-integrin, LFA-1, ICAM-1) on T cells, measured by flow cytometry, was compared in different subtypes of multiple sclerosis (MS) and related to future lesion development as seen as delta T1 and T2 lesion load per year on magnetic resonance imaging (MRI). LFA-1 and alpha4beta1-integrin showed higher expression on CD4 and CD8 T lymphocytes in the secondary progressive compared to the relapsing-remitting (CD4: p<0.01, p=ns, p<0.05; CD8: p<0.001, p<0.001, p<0.001, respectively) and primary progressive MS phase (CD4: p<0.001, p<0.01, p<0.05; CD8: p<0.01, p<0.01, p<0.001, respectively). The adhesion molecule expression of alpha4- (r=0.31; p<0.05) and beta1-integrin (r=0.38; p<0.01) on CD4+ cells and of LFA-1beta on both CD4+ and CD8+ (r=0.28, p<0.05) and r=0.29; p<0.05, respectively) cells was significantly related to increase in T2 lesion load. Our study provides further evidence for the involvement of integrins in lesion development, shown as T2 lesions on MRI in MS.
Eikelenboom
M Judith
MJ
Department of Neurology, VU University Medical Center, P.O. Box 7057, Amsterdam 1007, The Netherlands. j.eikelenboom@vumc.nl
Killestein
Joep
J
Izeboud
Thijs
T
Kalkers
Nynke F
NF
Baars
Paul A
PA
van Lier
Rene A W
RA
Barkhof
Frederik
F
Uitdehaag
Bernard M J
BM
Polman
Chris H
CH
D000328:Adult; D000704:Analysis of Variance; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000097:blood* / Q000145:classification; D003710:Demography; D018450:Disease Progression; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies; D013223:Statistics as Topic / Q000379:methods
D015815:Cell Adhesion Molecules