Platelets and metastasis revisited: a novel fatty link.
Platelets have long been suspected of having a role in cancer progression and metastasis that has largely been attributed to platelet-mediated enhancement of tumor cell survival, extravasation, and angiogenesis. A study in this issue of the JCI suggests that platelet-derived lysophosphatidic acid is coopted by aggressive breast and ovarian cancer cells as a tumor cell mitogen and promoter of osteolysis during bone metastasis.
Gupta
Gaorav P
GP
Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.
Massagué
Joan
J
D001792:Blood Platelets / Q000378:metabolism* / Q000502:physiology*; D001842:Bone and Bones / Q000473:pathology; D001943:Breast Neoplasms / Q000378:metabolism; D045744:Cell Line, Tumor; D018450:Disease Progression; D005260:Female; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic; D010014:Osteolysis; D010051:Ovarian Neoplasms / Q000378:metabolism
D008246:Lysophospholipids; C032881:lysophosphatidic acid