In vitro release study of transdermal delivery systems of progesterone.
A potential transdermal application of progesterone was investigated. In vitro diffusion studies of the drug were performed. Investigations were carried out in order to examine if the addition of urea, pantothenol, or laurocapram can enhance the release rates from Eud (Eudragit NE 30 D) matrices. Pantothenol and urea increased the release 1.4- to 1.6-fold. The transdermal therapeutic system (TTS) containing 10% laurocapram delivered the highest release rates with a 2.8-fold enhancement.
Valenta
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Institute of Pharmaceutical Technology, University of Vienna, A-1090 Vienna, Althanstrasse 14, Austria.
Biebel
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D000279:Administration, Cutaneous; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems; D011374:Progesterone / Q000008:administration & dosage*
D011374:Progesterone