In search of endocrine progenitor/stem cells in the human pancreas.
Motives to isolate endocrine precursor cells vary between clinical and basic research needs. In our case, the object has been to identify cell populations that could be used for cell replacement in situations of beta-cell deficiency, such as type 1 diabetes. Initially, as was the case with most laboratories oriented toward translational islet research, experimentation was geared more toward cell replication than to the identification and isolation of putative endocrine cell precursors.
Hayek
Alberto
A
The Islet Research Laboratory, Whittier Institute for Diabetes, Department of Pediatrics, UCSD-School of Medicine, 9894 Genesee Ave, La Jolla, CA 92037, USA. ahayek@ucsd.edu
D000328:Adult; D000818:Animals; D015415:Biomarkers; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division; D016332:Fetal Tissue Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis; D007515:Islets of Langerhans / Q000166:cytology* / Q000196:embryology; D016381:Islets of Langerhans Transplantation; D009419:Nerve Tissue Proteins / Q000032:analysis; D064231:Nestin; D009536:Niacinamide / Q000494:pharmacology; D010179:Pancreas / Q000166:cytology* / Q000502:physiology*
D015415:Biomarkers; D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin; D009536:Niacinamide