title: Neural correlates of speech anticipatory anxiety in generalized social phobia.
abstract: Patients with generalized social phobia fear embarrassment in most social situations. Little is known about its functional neuroanatomy. We studied BOLD-fMRI brain activity while generalized social phobics and healthy controls anticipated making public speeches. With anticipation minus rest, 8 phobics compared to 6 controls showed greater subcortical, limbic, and lateral paralimbic activity (pons, striatum, amygdala/uncus/anterior parahippocampus, insula, temporal pole)--regions important in automatic emotional processing--and less cortical activity (dorsal anterior cingulate/prefrontal cortex)--regions important in cognitive processing. Phobics may become so anxious, they cannot think clearly or vice versa.
authors.affiliation: Department of Psychiatry and Center for Advanced Imaging, Medical University of South Carolina Charleston (MUSC), SC 29425, USA. lorberjp@musc.edu
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Lorberbaum
authors.forename: Samet
authors.initials: S
authors.lastname: Kose
authors.forename: Michael R
authors.initials: MR
authors.lastname: Johnson
authors.forename: George W
authors.initials: GW
authors.lastname: Arana
authors.forename: Lindsay K
authors.initials: LK
authors.lastname: Sullivan
authors.forename: Mark B
authors.initials: MB
authors.lastname: Hamner
authors.forename: James C
authors.initials: JC
authors.lastname: Ballenger
authors.forename: R Bruce
authors.initials: RB
authors.lastname: Lydiard
authors.forename: Peter S
authors.initials: PS
authors.lastname: Brodrick
authors.forename: Daryl E
authors.initials: DE
authors.lastname: Bohning
authors.forename: Mark S
authors.initials: MS
authors.lastname: George
mesh_terms: D000328:Adult; D001007:Anxiety / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D001931:Brain Mapping; D000077463:Carbamide Peroxide; D016022:Case-Control Studies; D004338:Drug Combinations; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010545:Peroxides / Q000097:blood; D010698:Phobic Disorders / Q000503:physiopathology*; D013060:Speech; D013315:Stress, Psychological / Q000503:physiopathology; D014508:Urea / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D004338:Drug Combinations; D010545:Peroxides; D000077463:Carbamide Peroxide; D014508:Urea