title: Ultrasonographic criteria and tumor marker assay are good procedures for the diagnosis of ovarian neoplasia in preselected outpatients.
abstract: OBJECTIVE
  To identify parameters for the diagnosis of ovarian neoplasia using ultrasonography (US) and serum tumor marker (TM: CA125, CA19.9, CA15.3, AFP, CEA and estradiol) assay.
  
  
  METHODS
  Prospective study which included 373 women with increased ovarian volume (> 18 cm3 in premenopause and > 8 cm3 in postmenopause). US criteria (> or = 1) for surgery were: persistent (> 4 months) or increased cyst, cysts with > 1 thick septum or > or = 2 thin septa, cyst diameter > or = 7 cm, vegetation, calcification or cystic predominance (> 50%), solid tumor (> 50%). Doppler with a resistance index (RI) < 0.4 was considered abnormal.
  
  
  RESULTS
  Laparotomy was performed in 164 (44%) patients with 66 (40.2%) benign neoplasias and 19 (11.6%) malignant cases (73.6% at Stage I or II). Two hundred and nine patients were maintained on clinical follow-up. The sensitivity for neoplasia and malignant neoplasia was, respectively, for RI: 17 and 63.6 and RI plus TM: 53.1 and 90.9.
  
  
  CONCLUSIONS
  Ultrasound criteria and TM assay were indicated for the diagnosis of ovarian neoplasia.
authors.affiliation: Discipline of Gynecology and Obstetrics, Faculty of Medicine of Triângulo Mineiro, Uberaba-MG, Brazil.
authors.forename: E F C
authors.initials: EF
authors.lastname: Murta
authors.forename: C S
authors.initials: CS
authors.lastname: da Silva
authors.forename: R A S
authors.initials: RA
authors.lastname: Gomes
authors.forename: B M
authors.initials: BM
authors.lastname: Tavares-Murta
authors.forename: A L K O
authors.initials: AL
authors.lastname: Melo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000601:surgery; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler / Q000379:methods
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor