The effect of wax on compaction of microcrystalline cellulose beads made by extrusion and spheronization.
The effect of wax on the deformation behavior and compression characteristics of microcrystalline cellulose (Avicel PH-101) and acetaminophen (APAP) beads is described. Beads of Avicel PH-101 and APAP formulations were prepared using extrusion and spheronization technology. A waxy material, glyceryl behenate, N.F. (Compritol), was added to the formulations in amounts ranging from 10% to 70% of total solid weight. Beads with a selected particle size range of 16-30 mesh were compressed with an instrumented single punch Manesty F press utilizing a 7/16-in. flat-faced tooling set. Compaction profiles were generated for the tablets to evaluate the effect of wax on the densification of beads containing wax. Beads made without wax (the control formulation) required greater compression forces to form cohesive tablets. As the amount of wax in the bead formulation was increased, the beads become more plastic and compressible. The Heckel equation which relates densification to compression pressure was used to evaluate the deformation mechanisms of the bead formulations. The analysis shows that as the level of wax in the bead formulation is increased, the yield pressure decreases, indicating that the beads densify by a plastic deformation mechanism.
Iloañusi
N O
NO
Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy and Science, Philadelphia, Pennsylvania 19104, USA.
Schwartz
J B
JB
D000082:Acetaminophen / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D011312:Pressure
D005079:Excipients; D005227:Fatty Acids; C086409:glyceryl behenate; D000082:Acetaminophen; D002482:Cellulose; C109691:microcrystalline cellulose