title: ADDA: a domain database with global coverage of the protein universe.
abstract: We used the Automatic Domain Decomposition Algorithm (ADDA) to generate a database of protein domain families with complete coverage of all protein sequences. Sequences are split into domains and domains are grouped into protein domain families in a completely automated process. The current database contains domains for more than 1.5 million sequences in more than 40,000 domain families. In particular, there are 3828 novel domain families that do not overlap with the curated domain databases Pfam, SCOP and InterPro. The data are freely available for downloading and querying via a web interface (http://ekhidna.biocenter.helsinki.fi:9801/sqgraph/pairsdb).
authors.affiliation: Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland. andreas.heger@helsinki.fi
authors.forename: Andreas
authors.initials: A
authors.lastname: Heger
authors.forename: Christopher Andrew
authors.initials: CA
authors.lastname: Wilton
authors.forename: Ashwin
authors.initials: A
authors.lastname: Sivakumar
authors.forename: Liisa
authors.initials: L
authors.lastname: Holm
mesh_terms: D000465:Algorithms; D030562:Databases, Protein / Q000592:standards; D006801:Humans; D020407:Internet; D017434:Protein Structure, Tertiary; D011786:Quality Control; D020539:Sequence Analysis, Protein; D014584:User-Computer Interface