[Synthesis and antiaggregative activity of a new RGDF mimetic].
m-[4-Oxo-4-(piperazin-1-yl)butyrylamino)]benzoyl-D,L-beta-(3,4-methylenedioxyphenyl)-beta-alanine, a new mimetic of the peptide RGDF, was synthesized. This compound inhibited ADP-induced platelet aggregation in human blood plasma enriched with platelets with IC50 3.5 x 10(-8) M. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 6; see also http://www.maik.ru.
Krys'ko
A A
AA
Malovichko
O L
OL
Kabanova
T A
TA
Mazepa
A V
AV
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000409:Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D009842:Oligopeptides; D010879:Piperazines; D010975:Platelet Aggregation Inhibitors; C500343:m-(4-oxo-4-(piperazin-1-yl)butyrylamino)benzoyl-D,L-beta-(3,4-methylenedioxyphenyl)-beta-alanine; C084961:arginyl-glycyl-aspartyl-phenylalanine; D000244:Adenosine Diphosphate; D000409:Alanine