Biotransformation of hydrocortisone by a natural isolate of Nostoc muscorum.
Hydrocortisone was converted in the culture of an isolated strain of the cyanobacterium Nostoc muscorum PTCC 1636 into some androstane and pregnane derivatives. The microorganism was, isolated during a screening program from soil samples collected from paddy fields of north of Iran. The bioproducts obtained were purified using chromatographic methods and identified as 11beta-hydroxytestosterone, 11beta-hydroxyandrost-4-en-3,17-dione and 11beta,17alpha,20beta,21-tetrahydroxypregn-4-en-3-one on the basis of their spectroscopic features.
Yazdi
Mojtaba Tabatabaei
MT
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14174, Iran. mtabataba@sina.tums.ac.ir
Arabi
Homeira
H
Faramarzi
Mohammad Ali
MA
Ghasemi
Younes
Y
Amini
Mohsen
M
Shokravi
Shadman
S
Mohseni
Farzaneh Aziz
FA
D000736:Androstenes / Q000302:isolation & purification*; D001711:Biotransformation; D005285:Fermentation; D006854:Hydrocortisone / Q000378:metabolism*; D015394:Molecular Structure; D046937:Nostoc / Q000378:metabolism*; D011283:Pregnenes / Q000302:isolation & purification*
D000736:Androstenes; D011283:Pregnenes; D006854:Hydrocortisone