Caffeine: a valuable tool to study central fatigue in humans?
This review focuses on caffeine's effects on the central modulation of muscle activation in humans. The drug's effects on voluntary muscle activation, the Hoffman reflex, motor-evoked potentials, self-sustained firing, pain, and sensation are discussed, and the possibility that caffeine maybe useful in the study of central fatigue is explored.
Kalmar
Jayne M
JM
Department of Biology and 2School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
Cafarelli
E
E
D002110:Caffeine / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D019054:Evoked Potentials, Motor / Q000187:drug effects; D015444:Exercise / Q000502:physiology*; D005221:Fatigue / Q000378:metabolism*; D006801:Humans; D009044:Motor Cortex / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000294:innervation; D011930:Reaction Time; D011985:Receptors, Serotonin / Q000187:drug effects
D000697:Central Nervous System Stimulants; D011985:Receptors, Serotonin; D002110:Caffeine