[Association studies of G352A polymorphism of dopamine transporter gene in Han Chinese attention deficit hyperactivity disorder patients].
OBJECTIVE
To investigate association of the new polymorphism G352A in the dopamine transporter gene (DAT1) exon 15 with attention deficit hyperactivity disorder (ADHD) in Han Chinese children.


METHODS
The new mutant polymorphism G352A in the dopamine transporter gene (DAT1) exon 15 was found by the fluorescently-labeled dye-terminators assay. The study samples were comprised of 337 ADHD children, 207 unrelated controls and 201 integrated ADHD trios (included proband and biological parents). Associations of polymorphisms with ADHD and its subtypes were examined by: (i) comparing cases and controls; and (ii) using family-based association study in transmission-disequilibrium test (TDT).


RESULTS
The allele frequencies at the DAT1 G352A locus in the control samples were 79.5% for 352G and 20.5% for 352A respectively. Association studies revealed no association between G352A in exon 15 of DAT1 and ADHD. But after a stratification by gender, there was possible association between G352A and ADHD girls: the 352G allele had a tendency to be preferentially transmitted to ADHD girls.


CONCLUSIONS
There is no association between G352A, the new polymorphism, in exon 15 of DAT1 and ADHD. The 352G allele has a tendency to be preferentially transmitted to ADHD girls, but the findings require replication before drawing a definitive conclusion.
Qian
Qiu-jin
QJ
Peking University Institute of Mental Health, Beijing 100083, China.
Wang
Yu-feng
YF
Zhou
Ru-lun
RL
Yang
Li
L
Li
Jun
J
D000293:Adolescent; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001289:Attention Deficit Disorder with Hyperactivity / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D002648:Child; D002681:China; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005091:Exons; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide
D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human