The SBASE domain sequence resource, release 12: prediction of protein domain-architecture using support vector machines.
SBASE (http://www.icgeb.trieste.it/sbase) is an online resource designed to facilitate the detection of domain homologies based on sequence database search. The present release of the SBASE A library of protein domain sequences contains 972,397 protein sequence segments annotated by structure, function, ligand-binding or cellular topology, clustered into 8547 domain groups. SBASE B contains 169,916 domain sequences clustered into 2526 less well-characterized groups. Domain prediction is based on an evaluation of database search results in comparison with a 'similarity network' of inter-sequence similarity scores, using support vector machines trained on similarity search results of known domains.
Vlahovicek
Kristian
K
ICGEB-International Center for Genetic Engineering and Biotechnology, Area Science Park, 34012 Trieste, Italy.
Kaján
László
L
Agoston
Vilmos
V
Pongor
Sándor
S
D001185:Artificial Intelligence; D030562:Databases, Protein; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein
D011506:Proteins