title: Alkynyltrifluoroborates as versatile tools in organic synthesis: a new route to spiroketals.
abstract: [reaction: see text] A simple and efficient two-step approach to spiroketals is described. Key steps include the preparation of functionalized hydroxyl alpha-alkynones by ring-opening reactions of lactones with lithium alkynyltrifluoroborates followed by a palladium-catalyzed hydrogenation/spirocyclization of the prespiroketal intermediate.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Doubský
authors.forename: Ludvík
authors.initials: L
authors.lastname: Streinz
authors.forename: David
authors.initials: D
authors.lastname: Saman
authors.forename: Jirí
authors.initials: J
authors.lastname: Zedník
authors.forename: Bohumír
authors.initials: B
authors.lastname: Koutek
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D008094:Lithium / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001896:Boron Compounds; D013141:Spiro Compounds; D010165:Palladium; D008094:Lithium