Prognostic factors responsible for survival in sex cord stromal tumors of the ovary--a multivariate analysis.
OBJECTIVE
To evaluate prognostic factors that impacts the survival of women with sex cord stromal tumors of the ovary (SCST).


METHODS
Cases were identified from tumor registry databases at three academic institutions between 1975 and 2003. Patient characteristics, surgical treatment, adjuvant therapy, pathologic and follow-up information were collected from hospital charts and clinic records. Kaplan-Meier and Cox proportional hazards analyses were used to identify predictors of outcome.


RESULTS
Eighty-three women (median age: 49 years) with SCST of the ovary, including 73 with granulosa and 10 with Sertoli-Leydig cell tumors were identified. Fifty-one were stage I, 8 stage II, 10 stage III, 3 stage IV, and 11 patients were unstaged. The median and 5-year disease-specific survival of women with stage I-II vs. III-IV was 180 months and 85% compared to 58 months and 48%, respectively (P = 0.012). Furthermore, age <50 (P = 0.003), premenopausal status (P = 0.013), tumor size < 10 cm (P = 0.003), lack of lymph node invasion (P < 0.0005), and absence of residual disease (P = 0.002) were all significant predictors for improved survival. Of the patients who received adjuvant treatment, chemotherapy did not impact survival (P = 0.11). Twelve of 51 stage I patients underwent fertility-sparing surgery with three recurrences. In multivariate analysis, age <50, smaller tumor size, and absence of residual disease remained as independent prognostic factors. The median follow up was 58 months (range: 1-310).


CONCLUSIONS
Age <50, smaller tumor size, and absence of residual disease are important predictors for improved survival in patients with SCST of the ovary.
Chan
John K
JK
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, HH333, Stanford Cancer Center, Stanford, CA 94305, USA. johnchan@stanford.edu
Zhang
Mallory
M
Kaleb
Vanessa
V
Loizzi
Vera
V
Benjamin
Jacqueline
J
Vasilev
Steve
S
Osann
Kathryn
K
Disaia
Philip J
PJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D012042:Registries; D018312:Sex Cord-Gonadal Stromal Tumors / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate