title: [Anti-mutagenesis effects of total flavonoids of Astragalus].
abstract: OBJECTIVE
  To investigate the anti-mutagenic action of the total flavonoids of Astragalus (TFA).
  
  
  METHODS
  Three groups of concentrations of TFA and one inducer group were used. The anti-mutagenic action of TFA was studied by experiments in vitro and in vivo including miconucleolus assay, semen teraogenesis test and gene mutagenesis of V79/HGPRT.
  
  
  RESULTS
  TFA did not affect the weight of the mice during the experiment period. The high concentration of TFA could significantly reduce cyclohophamide-induced miconucleolus number and gene mutagenesis of V79/HGPRT compared with inducer group. However, TFA did not make statistic change in the semen teraogenesis induced by mitomycin C.
  
  
  CONCLUSIONS
  TFA has antimutagenesis effect.
authors.affiliation: Department of Biochemistry, PLA General Hospital, Beijing 100853, China. deqingw@vip.sina.com
authors.forename: De-qing
authors.initials: DQ
authors.lastname: Wang
authors.forename: Ya-ping
authors.initials: YP
authors.lastname: Tian
authors.forename: Shu-zhen
authors.initials: SZ
authors.lastname: Song
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D027885:Astragalus propinquus / Q000737:chemistry; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D016296:Mutagenesis / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry; D013737:Testis / Q000166:cytology / Q000187:drug effects
chemical_list: D016587:Antimutagenic Agents; D005419:Flavonoids