title: In vivo single-shot three-dimensionally localized multiple quantum spectroscopy of GABA in the human brain with improved spectral selectivity.
abstract: A single-shot multiple quantum filtering method is developed that uses two double-band frequency selective pulses for enhanced spectral selectivity in combination with a slice-selective 90 degrees, a slice-selective universal rotator 90 degrees, and a spectral-spatial pulse composed of two slice-selective universal rotator 45 degrees pulses for single-shot three-dimensional localization. The use of this selective multiple quantum filtering method for C(3) and C(4) methylene protons of GABA resulted in improved spectral selectivity for GABA and effective suppression of overlapping signals such as creatine and glutathione in each single scan, providing reliable measurements of the GABA doublet in all subjects. The concentration of GABA was measured to be 0.7 +/- 0.2 micromol/g (means +/- SD, n = 15) in the fronto-parietal region of the human brain in vivo.
authors.affiliation: The Nathan Kline Institute, Medical Physics, Orangeburg, NY 10962, USA. iychoi@nki.rfmh.org
authors.forename: In-Young
authors.initials: IY
authors.lastname: Choi
authors.forename: Sang-Pil
authors.initials: SP
authors.lastname: Lee
authors.forename: Jun
authors.initials: J
authors.lastname: Shen
mesh_terms: D000328:Adult; D001923:Brain Chemistry; D005625:Frontal Lobe / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010296:Parietal Lobe / Q000737:chemistry; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted; D005680:gamma-Aminobutyric Acid / Q000032:analysis* / Q000737:chemistry
chemical_list: D005680:gamma-Aminobutyric Acid