title: A foxy intoxication.
abstract: Foxy is the colloquial name for the hallucinogen 5-ethoxy-diisopropyltryptamine (5-MeO-DIPT). A non-fatality involving a 23-year-old Caucasian man who ingested a capsule containing 5-MeO-DIPT is described. He presented to the Emergency Department, not with visual nor auditory hallucinations but with sensory hallucinations, that of formication and paranoia. He was observed and given supportive care for 4 h, then discharged without any known sequelae. Blood and urine were collected for laboratory analyses. Foxy and its metabolites were identified in urine by gas chromatography-mass spectrometry. The concentrations of 5-MeO-DIPT in the serum and urine were 0.14 and 1.6 microg/mL, respectively. The drug undergoes oxidative deamination to form 5-methoxy-indole acetic acid. The urinary concentration of this metabolite was 0.17 microg/mL. Also, the urine contained three other related compounds. Two of them have been described in a previous case of 5-MeO-DIPT ingestion as 5-methoxy-isopropyltryptamine (5-MeO-IPT) and 5-methoxy-diisopropyltryptamine-N'-oxide (5-MeO-DIPT-N'-oxide). The third compound was substantially present in the urine and was tentatively identified as 5-hydroxy-diisopropyltryptamine (5-OH-DIPT). Only the parent drug, 5-MeO-DIPT was detected in the serum sample.
authors.affiliation: Clinical Pathology, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, MI 48073, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Wilson
authors.forename: Frank
authors.initials: F
authors.lastname: McGeorge
authors.forename: Susan
authors.initials: S
authors.lastname: Smolinske
authors.forename: Robert
authors.initials: R
authors.lastname: Meatherall
mesh_terms: D008735:5-Methoxytryptamine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine; D000328:Adult; D003497:Cyclic N-Oxides / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000031:analogs & derivatives* / Q000652:urine; D008297:Male; D010259:Paranoid Disorders / Q000139:chemically induced*; D010292:Paresthesia / Q000139:chemically induced*
chemical_list: C487455:5-methoxy-N,N-diisopropyltryptamine N-oxide; C487454:5-methoxy-N-isopropyltryptamine; D003497:Cyclic N-Oxides; C033696:5-methoxy-N,N-diisopropyltryptamine; C001736:5-methoxyindoleacetic acid; D008735:5-Methoxytryptamine; D006897:Hydroxyindoleacetic Acid