title: Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions.
abstract: Tetrazole and acylsulfonamide organocatalysts derived from proline have been synthesised and applied to the asymmetric Mannich, nitro-Michael and aldol reactions to give results that are superior to the proline-catalysed counterpart.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Alexander J A
authors.initials: AJ
authors.lastname: Cobb
authors.forename: David M
authors.initials: DM
authors.lastname: Shaw
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Longbottom
authors.forename: Johan B
authors.initials: JB
authors.lastname: Gold
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007659:Ketones; D009574:Nitro Compounds; D013449:Sulfonamides; D013777:Tetrazoles; C045574:1H-tetrazole; D011392:Proline