title: Shiga-toxigenic Escherichia coli-inoculated neonatal piglets develop kidney lesions that are comparable to those in humans with hemolytic-uremic syndrome.
abstract: Kidney lesions similar to those in humans with hemolytic-uremic syndrome were observed histologically in 82 of 122 piglets inoculated intragastrically with Shiga-toxigenic Escherichia coli but not in 29 controls. The locations of lesions matched locations where Stx-2 binding and Gb3 (globotriasylceramide receptors for Stx) were identified immunohistochemically.
authors.affiliation: National Animal Disease Center, USDA, ARS, P.O. Box 70, Ames, IA 50010-0070, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Pohlenz
authors.forename: K R
authors.initials: KR
authors.lastname: Winter
authors.forename: E A
authors.initials: EA
authors.lastname: Dean-Nystrom
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004926:Escherichia coli / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000473:pathology*; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology*; D012189:Retrospective Studies; D022641:Shiga Toxin 2 / Q000378:metabolism / Q000633:toxicity*; D013552:Swine; D014281:Trihexosylceramides / Q000378:metabolism
chemical_list: D022641:Shiga Toxin 2; D014281:Trihexosylceramides; C018549:globotriaosylceramide