title: Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent.
abstract: Bakuchiol, extracted from the plant Psoralea corylifolia, has been proven to have anti-tumor, cytotoxic, anti-microbial and anti-inflammatory activity. In order to study if radiolabeled bakuchiol exhibits enhanced cytotoxicity, bakuchiol was radiolabeled with 125I. In-vitro uptake studies of 125I-bakuchiol were carried out using LS-A (lymphosarcoma) and barcl-95 (radiation-induced thymic lymphoma) ascitic and solid tumor cells of murine origin. In both LS-A and barcl-95, 125I-bakuchiol showed significant uptake. Viability studies showed that the radioiodinated compound showed greater cytotoxic effect than bakuchiol.
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
authors.forename: Ketaki
authors.initials: K
authors.lastname: Bapat
authors.forename: G J
authors.initials: GJ
authors.lastname: Chintalwar
authors.forename: Usha
authors.initials: U
authors.lastname: Pandey
authors.forename: V S
authors.initials: VS
authors.lastname: Thakur
authors.forename: H D
authors.initials: HD
authors.lastname: Sarma
authors.forename: Grace
authors.initials: G
authors.lastname: Samuel
authors.forename: M R A
authors.initials: MR
authors.lastname: Pillai
authors.forename: S
authors.initials: S
authors.lastname: Chattopadhyay
authors.forename: Meera
authors.initials: M
authors.lastname: Venkatesh
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics / Q000494:pharmacology*; D007553:Isotope Labeling; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000532:radiotherapy; D051379:Mice; D010636:Phenols / Q000493:pharmacokinetics / Q000494:pharmacology*; D010936:Plant Extracts / Q000378:metabolism; D029907:Psoralea / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007457:Iodine Radioisotopes; D010636:Phenols; D010936:Plant Extracts; D019275:Radiopharmaceuticals; C012765:bakuchiol