title: [Multiple extrahepatic manifestations in a patient with chronic hepatitis C treated with interferon-alfa].
abstract: The case of a 61-years-old female patient with chronic hepatitis C who developed multiple consecutive extrahepatic manifestations is reported. One of these manifestations (lichen planus) appeared before HCV-related chronic hepatitis was diagnosed and treated with interferon-alpha, suggesting that it was likely associated with HCV itself. Other manifestations appeared during IFN-alpha treatment (polyarthritis) or after the end of treatment (ulcerative cholitis, sarcoidosis) implying a role for either HCV or IFN-alpha treatment in the pathogenesis of extrahepatic manifestations.
authors.affiliation: Dipartimento di Clinica Medica, Immunologia e Malattie Infettive, Sezione di Medicina Interna, Università, Bari. n.napoli@intmed.uniba.it
authors.forename: Nicola
authors.initials: N
authors.lastname: Napoli
authors.forename: Cosimo
authors.initials: C
authors.lastname: Tortorella
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Deramo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Antonaci
authors.forename: Carmen Vita
authors.initials: CV
authors.lastname: Parisi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Antonaci
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D001168:Arthritis / Q000139:chemically induced / Q000209:etiology*; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use*; D008010:Lichen Planus / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D017565:Sarcoidosis, Pulmonary / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D016898:Interferon-alpha; D011241:Prednisone