title: [Physiopathology of bipolar disorders: what have changed in the last 10 years?].
abstract: Despite recent efforts to understand the neurobiology of Bipolar Disorder (BD), the exact pathophysiology remains undetermined. Due to the effects of various psychopharmacological agents, initial research focused on the study of biogenic amines. Recent evidence has shown that dysfunction in intracellular signaling systems and gene expression may be associated with BD. These alterations may cause interruptions in mood regulating circuits such as the limbic system, striatum and prefrontal cortex, and the neuroprotective effects of mood stabilizers may reverse this pathological process. This study aims to update the recent findings relative to the neurochemistry of BD.
authors.affiliation: Laboratório de Psiquiatria Experimental, Centro de Pesquisas, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS. kapcz@terra.com.br
authors.forename: Flávio
authors.initials: F
authors.lastname: Kapczinski
authors.forename: Benício Noronha
authors.initials: BN
authors.lastname: Frey
authors.forename: Vanessa
authors.initials: V
authors.lastname: Zannatto
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D002908:Chronic Disease; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D014150:Antipsychotic Agents; D036341:Intercellular Signaling Peptides and Proteins; D018377:Neurotransmitter Agents