title: [Effect of guizhi tang and its active components on the fever induced by EP3 agonist].
abstract: OBJECTIVE
  To investigate the effect of Guizhi Tang and its active components on the fever induced by EP3 receptor agonist sulprostone in rats.
  
  
  METHODS
  The rise in body temperature evoked by a LCV(lateral cerebroventricle)-injection of sulprostone was compared with that of sulprostone induced-fever rats pretreated with Guizgi Tang and its active compounds, cinnamaldehyde, cinnamic acid and total glucosides of paeony.
  
  
  RESULTS
  Pretreatments with Guizhi Tang and cinnamaldehyde inhibited the rise in body temperature induced by sulprostone, while cinnamic acid tended to augment the fever. The sulprostone-induced fever was blocked by an ip pretreatment of total glucosides of paeony even below the basement.
  
  
  CONCLUSIONS
  Present data suggest that interruption with the down-stream events of EP3 receptor may contribute to the antipyretic action of Guizhi Tang, cinnamaldehyde and the total glucosides of paeony, while cinnamic acid may have no such effect.
authors.affiliation: Department of Pharmacology, Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China. leech-h@etang.com
authors.forename: Cang-hai
authors.initials: CH
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Hai-ru
authors.initials: HR
authors.lastname: Huo
authors.forename: Xu-liang
authors.initials: XL
authors.lastname: Kang
authors.forename: Ting-liang
authors.initials: TL
authors.lastname: Jiang
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002934:Cinnamates / Q000302:isolation & purification / Q000494:pharmacology; D015232:Dinoprostone / Q000031:analogs & derivatives; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D029596:Paeonia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D018078:Receptors, Prostaglandin E / Q000819:agonists; D058308:Receptors, Prostaglandin E, EP3 Subtype
chemical_list: D018712:Analgesics, Non-Narcotic; D002934:Cinnamates; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D018078:Receptors, Prostaglandin E; D058308:Receptors, Prostaglandin E, EP3 Subtype; C029010:cinnamic acid; C016767:sulprostone; D000171:Acrolein; D015232:Dinoprostone; C012843:cinnamaldehyde