Towards defining heart failure in adults with congenital heart disease.
Injury to the myocardium disrupts geometric integrity and results in changes to intracardiac pressure, wall stress and tension, and the pattern of blood flow through the heart. Significant disruption to pump function results in heart failure which is defined in terms of symptoms: breathlessness and fatigue, signs of salt and water retention, and neurohormonal activation. This syndrome most commonly occurs in the context of injury due to ischaemic heart disease and dilated cardiomyopathy but because patients with congenital heart disease (CHD) are born with sometimes gross distortions of cardiac anatomy they too are subject to the forces that drive heart failure. This paper explores the available data relating to the clinical and neurohormonal manifestations of heart failure in patients with congenital heart disease and describes how, by additionally exploring events at a cellular level, we may be able to arrive at a definition of heart failure relevant to this population.
Bolger
Aidan P
AP
National Heart and Lung Institute, Imperial College, London, UK. a.bolger@imperial.ac.uk
Gatzoulis
Michael A
MA
D006321:Heart / Q000502:physiology; D006330:Heart Defects, Congenital / Q000150:complications* / Q000503:physiopathology; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D045265:Natriuretic Peptides / Q000097:blood; D018377:Neurotransmitter Agents / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D018754:Ventricular Dysfunction / Q000209:etiology
D045265:Natriuretic Peptides; D018377:Neurotransmitter Agents