The Ca2+/Mn2+ pumps in the Golgi apparatus.
Recent evidence highlights the functional importance of the Golgi apparatus as an agonist-sensitive intracellular Ca(2+) store. Besides Ca(2+)-release channels and Ca(2+)-binding proteins, the Golgi complex contains Ca(2+)-uptake mechanisms consisting of the well-known sarco/endoplasmic reticulum Ca(2+)-transport ATPases (SERCA) and the much less characterized secretory-pathway Ca(2+)-transport ATPases (SPCA). SPCA supplies the Golgi compartments and, possibly, the more distal compartments of the secretory pathway with both Ca(2+) and Mn(2+) and, therefore, plays an important role in the cytosolic and intra-Golgi Ca(2+) and Mn(2+) homeostasis. Mutations in the human gene encoding the SPCA1 pump (ATP2C1) resulting in Hailey-Hailey disease, an autosomal dominant skin disorder, are discussed.
Van Baelen
Kurt
K
Laboratorium voor Fysiologie, K.U. Leuven Campus Gasthuisberg O/N, Herestraat 49, B-3000, Leuven, Belgium.
Dode
Leonard
L
Vanoevelen
Jo
J
Callewaert
Geert
G
De Smedt
Humbert
H
Missiaen
Ludwig
L
Parys
Jan B
JB
Raeymaekers
Luc
L
Wuytack
Frank
F
D000252:Calcium-Transporting ATPases / Q000737:chemistry / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D008345:Manganese / Q000737:chemistry / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D016506:Pemphigus, Benign Familial / Q000378:metabolism; D011487:Protein Conformation
D026901:Membrane Transport Proteins; D008345:Manganese; D000252:Calcium-Transporting ATPases