C-kit as a target in the treatment of acute myelogenous leukemia.
Acute myelogenous leukemia (AML) is a difficult disease to treat. Novel treatment strategies, including molecular targeted therapy, are currently being explored. The c-kit receptor represents a potential therapeutic target for AML. The receptor is expressed on more than 10% of blasts in 64% of de novo AMLs and 95% of relapsed AMLs. C-kit mediates proliferation and anti-apoptotic effects in AML. This review will discuss the biology of c-kit in normal and malignant hematopoiesis, and the recent clinical trials targeting c-kit in AML.
Advani
Anjali S
AS
Department of Hematology Medical Oncology, Desk 35, The Cleveland Clinic Lerner College of Medicine, 9500 Euclid Avenue, Cleveland, OH 44195, USA. advania@ccf.org
D000208:Acute Disease; D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001549:Benzamides; D045744:Cell Line, Tumor; D002986:Clinical Trials as Topic; D006410:Hematopoiesis; D006801:Humans; D000068877:Imatinib Mesylate; D007211:Indoles / Q000494:pharmacology / Q000627:therapeutic use; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000235:genetics; D051379:Mice; D000078183:Oxindoles; D010879:Piperazines / Q000627:therapeutic use; D011422:Propionates; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D019009:Proto-Oncogene Proteins c-kit / Q000737:chemistry / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D011743:Pyrimidines / Q000627:therapeutic use; D011758:Pyrroles / Q000494:pharmacology / Q000627:therapeutic use; D019089:Stem Cell Factor / Q000502:physiology* / Q000627:therapeutic use
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D001549:Benzamides; D007211:Indoles; D000078183:Oxindoles; D010879:Piperazines; D011422:Propionates; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D011758:Pyrroles; D019089:Stem Cell Factor; C116890:Semaxinib; D000068877:Imatinib Mesylate; C412603:orantinib; D019009:Proto-Oncogene Proteins c-kit