title: Pathologic hepatic Tc-99m-MDP uptake in polyostotic fibrous dysplasia.
abstract: Fibrous dysplasia of bone is a congenital, sporadic developmental disorder characterized by immature fibrous connective tissue and bone deformities. Hepatic Tc-99m-MDP uptake is a rare, serendipitous finding during bone scanning studies. The present patient was a 25-year-old male who had severe polyostotic fibrous dysplasia. On Tc-99m-MDP (methylene diphosphonate) bone scintigraphy, increased activity accumulations were seen on multiple ribs, vertebrae and base of the cranium. In addition, diffuse increased pathologic uptake of Tc-99m-MDP in the liver was shown. Intravenous pamidronate was administered monthly for two months. In the third week of the last administration Tc-99m-MDP bone scintigraphy was performed again, but despite sustained bone involvement, pathologic hepatic uptake was not seen on the scan. We thought that pathologic hepatic Tc-99m-MDP accumulation, may be related to the formation and aggregation of calcium oxalate and phosphate crystals which improved with pamidromat treatment.
authors.affiliation: Department of Nuclear Medicine, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey. ekekilli@inonu.edu.tr
authors.forename: Ersoy
authors.initials: E
authors.lastname: Kekilli
authors.forename: Cengiz
authors.initials: C
authors.lastname: Yagmur
authors.forename: Akin
authors.initials: A
authors.lastname: Kuzucu
authors.forename: Omer
authors.initials: O
authors.lastname: Soysal
authors.forename: Ayse Sertkaya
authors.initials: AS
authors.lastname: Cikim
authors.forename: Kadir
authors.initials: K
authors.lastname: Ertem
mesh_terms: D000328:Adult; D002637:Chest Pain / Q000175:diagnosis / Q000209:etiology; D005359:Fibrous Dysplasia, Polyostotic / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D033162:Incidental Findings; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics*
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate