Repair of cartilage defects with periosteal grafts.
Alternative sources for repair of cartilage defects are limited and donor sites are associated with morbidity. It is known that cartilage development from periosteal grafts is possible. Various factors have been found positively to affect this process in experimental settings. However, all of these studies were limited to joint cartilage. We conducted an experimental study in rabbits for the investigation of the elastic cartilage regeneration from perichondrial and periosteal grafts together with the effects of hyaluronan on this process. 1 x 1 cm(2) cartilage defects were created on the elastic ear cartilage of rabbits. Four experimental groups with 18 ears in each group were created: Group 1 (repair with perichondrium graft), group 2 (repair with periosteum graft), group 3 (repair with periosteum graft+hyaluronan), group 4 (defect-only control group). Macroscopic and microscopic evaluations were done on the 4th, 8th and 12th weeks. Cellular morphology of the regenerated cartilage and its integration and similarity with adjacent cartilage were evaluated. Cartilage regeneration groups 1, 2 and 3 were found to be statistically different from the control group. There was not a significant difference between groups 1 and 2 or 2 and 3. There is no significant difference between perichondrial and periosteal grafts in cartilage regeneration, and hyaluronan has no beneficial effect on this process.
Ulutaş
Kutay
K
Department of Plastic and Reconstructive Surgery, Medical Faculty, Dokuz Eylül University, 35340 Inciralti, Izmir, Turkey. kutayu@mailcity.com
Menderes
Adnan
A
Karaca
Can
C
Ozkal
Sermin
S
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004423:Ear; D004425:Ear Cartilage / Q000187:drug effects / Q000293:injuries* / Q000601:surgery; D004548:Elasticity; D006820:Hyaluronic Acid / Q000494:pharmacology*; D010521:Periosteum / Q000637:transplantation*; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects / Q000502:physiology
D000276:Adjuvants, Immunologic; D006820:Hyaluronic Acid