Quantitative NAT for pathogen inactivation verification.
A novel Quantitative Nucleic Acid Test (Q-NAT) technology has been developed to demonstrate, quantify and verify pathogen inactivation by methods that break pathogen nucleic acids, specifically, gamma irradiation. The Q-NAT technology provides significant advantages in cost, efficiency and broad applicability compared with traditional methods for pathogen inactivation detection and quantification such as cell culture.
McKenney
K
K
Clearant Inc., Gaithersburg, MD 20879, USA. kmckenney@clearant.com
Gillmeister
L
L
Marlowe
K
K
Armistead
D
D
Burgess
W
W
Drohan
W
W
D001688:Biological Products / Q000302:isolation & purification; D005720:Gamma Rays; D006801:Humans; D009696:Nucleic Acids / Q000032:analysis / Q000528:radiation effects; D016732:Parvovirus B19, Human / Q000235:genetics / Q000302:isolation & purification / Q000528:radiation effects; D016133:Polymerase Chain Reaction / Q000379:methods; D012449:Safety; D014773:Virology / Q000379:methods*; D038301:Virus Inactivation; D014780:Viruses / Q000235:genetics* / Q000302:isolation & purification* / Q000528:radiation effects
D001688:Biological Products; D009696:Nucleic Acids