[Synthesis and the drug release properties of poly(acrylamide-co-glycosylallylamide) hydrogels].
Sugar-containing monomer glycosylallylamide (AAG) was synthesized by allyl amine and delta-gluconolactone in dimethylformamide (DMF) solution. The sugar-based hydrogels were prepared by free radical crosslinking copolymerization of AAG and acrylamide (AM). The release properties of Aspirin from xerogels matrices were studied and the release mechanism of Aspirin was further identified by evaluating the n value in Peppas equation. The results indicate that the drug release decreases with the increase of the sugar content of hydrogel.
Li
Lingbing
L
School of Pharmaceutics, Shandong University, Ji'nan 250012, China. cn-lbli@263.sina.com
Tan
Yebang
Y
Meng
Jianwen
J
D020106:Acrylamide / Q000138:chemical synthesis / Q000737:chemistry*; D001241:Aspirin / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D005942:Gluconates / Q000138:chemical synthesis / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D007783:Lactones; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
D003692:Delayed-Action Preparations; D005942:Gluconates; D020100:Hydrogels; D007783:Lactones; D011108:Polymers; D020106:Acrylamide; D001241:Aspirin; C010730:beta-glucono-1,5-lactone