Relationship between plasma and hippocampal lipid peroxidation in obese and hypertensive SHR/NDmcr-cp rats.
1. It has been suggested that hypertension, hyperlipidaemia and diabetes participate in the onset and development of dementia. 2. To understand cognitive dysfunction in metabolic syndrome, the relationship between the plasma and the hippocampus regarding fatty acid composition and lipid peroxidation was estimated in genetically hypertensive and obese SHR/NDmcr-cp rats (SHR-cp) aged 7-9 and 18-20 weeks. 3. Levels of total fatty acids and lipid peroxide in the plasma were much higher (by 200-500%) in SHR-cp compared with age-matched control rats (Wistar-Kyoto rats). However, in the hippocampus these levels were not significantly different between the two groups of rats. 4. Levels of hippocampal lipid peroxide in both groups increased significantly with ageing. 5. These results indicate that, in SHR-cp, lipid peroxidation in the hippocampus would not be affected even if plasma levels of fatty acids and lipid peroxide increased markedly, when ageing is not a predicative factor.
Hashimoto
Michio
M
Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Japan. michio1@med.shimane-u
Kubota
Yoko
Y
Tanaka
Naoko
N
Yamaguchi
Yu
Y
Fujii
Yoshimi
Y
Kagota
Satomi
S
Kawakita
Eisuke
E
Shido
Osamu
O
Kunitomo
Masaru
M
Shinozuka
Kazumasa
K
D000375:Aging / Q000378:metabolism; D000818:Animals; D003072:Cognition Disorders / Q000209:etiology; D005227:Fatty Acids / Q000097:blood; D006624:Hippocampus / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D024821:Metabolic Syndrome / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D005227:Fatty Acids; D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde