A reciprocal t(4;9)(q31;p22) in a solitary neurofibroma.
Cytogenetic reports of solitary neurofibromas are rare and, to our knowledge, no clonal reciprocal translocations have been reported in these tumors. Reciprocal chromosome translocations have been identified in a number of solid tumors and can have both diagnostic and prognostic significance. We report the first case of a solitary circumscribed neurofibroma with a (4;9)(q31;p22) balanced reciprocal translocation as the sole cytogenetic abnormality.
Sawyer
Jeffrey R
JR
Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. sawyerjefferyr@uams.edu
Parr
Lewis G
LG
Gokden
Neriman
N
Nicholas
Richard W
RW
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D007621:Karyotyping; D019042:Muscle Neoplasms / Q000235:genetics / Q000473:pathology; D009455:Neurofibroma / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
D015703:Antigens, CD