title: Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors.
abstract: Angiogenesis in tumors is controlled by the so-called 'angiogenic switch' which allows the passage from low invasive and poorly vascularized tumors to highly invasive and angiogenic tumors. A number of cellular stress factors such as hypoxia, nutrient deprivation or inducers of reactive oxygen species (ROS) are important stimuli of angiogenic signalling. The HIF system plays a significant role in several of these effects and the molecular mechanisms of its regulation have recently been characterized. In addition, HIF-independent mechanisms have been described which involved number of other molecules and transcription factors such as nuclear factor-(kappa)B (NF-(kappa)B) and p53. p53 is an important intracellular mediator of the stress response and is now also recognized as a modifier of the angiogenic response. p53 may interact with the HIF system but may also have direct effects on angiogenesis regulators or interfere with translation mechanisms of angiogenesis factors.
authors.affiliation: Molecular Mechanisms of Angiogenesis Laboratory, INSERM EMI 0113, University Bordeaux I, Avenue des Facultes, 33 405 Talence, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: North
authors.forename: Michel
authors.initials: M
authors.lastname: Moenner
authors.forename: Andreas
authors.initials: A
authors.lastname: Bikfalvi
mesh_terms: D015687:Cell Hypoxia; D006801:Humans; D018977:Micronutrients / Q000378:metabolism; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009369:Neoplasms / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics* / Q000503:physiopathology*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000494:pharmacology*
chemical_list: D018977:Micronutrients; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53