title: Isatin-derived antibacterial and antifungal compounds and their transition metal complexes.
abstract: A series of isatins incorporating thiazole, thiadiazole, benzothiazole and p-toluene sulfonyl hydrazide moieties, along with their cobalt(II), copper(II), nickel(II) and zinc(II) metal complexes have been synthesized and characterized by elemental analyses, molar conductances, magnetic moments, IR, NMR and electronic spectral data. These compounds have been screened for antibacterial activity against Escherichia coli, Bacillus subtillis, Shigella flexneri, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi, and for antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata using the agar-well diffusion method. All the synthesized compounds have shown good affinity as antibacterial and/or antifungal agents which increased in most of the cases on complexation with the metal ions.
authors.affiliation: Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
authors.forename: Humayun
authors.initials: H
authors.lastname: Pervez
authors.forename: A
authors.initials: A
authors.lastname: Rauf
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Khan
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002247:Carbon Isotopes; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects; D007510:Isatin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D019216:Metals, Heavy / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011522:Protons; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D002247:Carbon Isotopes; D008024:Ligands; D019216:Metals, Heavy; D009942:Organometallic Compounds; D011522:Protons; D007510:Isatin