title: Preparation of tertiary alkyl carbinamines, propargylamines, and alpha-heteroarylamines by ketone-based aminoalkylation.
abstract: Ketones 6a-i were converted into their benzotriazolylamine adducts 8a-i either directly from the corresponding ketone 6a or via enamines 7b-i. Adducts 8a-i on treatment with Grignard reagents, lithium phenylacetylide, or heteroaryllithiums gave tertiary alkyl carbinamines 9a-h (47-61%), propargylamines 10a-i (30-98%), and alpha-heteroarylamines 11a-k (44-85%), respectively.
authors.affiliation: Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
authors.forename: Hongfang
authors.initials: H
authors.lastname: Yang
authors.forename: Sandeep K
authors.initials: SK
authors.lastname: Singh