Effect of hormone therapy on mortality rates among women with heart failure and coronary artery disease.
Randomized, controlled trial data from the Heart and Estrogen-progestin Replacement Study were used to evaluate the effect of estrogen plus progestin use on all-cause mortality in women with heart failure and coronary disease. Over the 4.1-year follow-up, estrogen plus progestin use had no effect on all-cause mortality (hazard ratio 1.0, 95% confidence interval 0.7 to 1.4, p = 0.8) in women with heart failure and coronary disease.
Bibbins-Domingo
Kirsten
K
Division of General Internal Medicine, San Francisco General Hospital, University of California-San Francisco, San Francisco, CA 94143, USA. bibbinsk@medicine.ucsf.edu
Lin
Feng
F
Vittinghoff
Eric
E
Barrett-Connor
Elizabeth
E
Hulley
Stephen B
SB
Grady
Deborah
D
Shlipak
Michael G
MG
D000368:Aged; D002140:California / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000150:complications / Q000453:epidemiology / Q000401:mortality* / Q000517:prevention & control*; D015914:Estrogen Replacement Therapy; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000150:complications / Q000453:epidemiology / Q000401:mortality* / Q000517:prevention & control*; D006801:Humans; D008525:Medroxyprogesterone / Q000008:administration & dosage; D016016:Proportional Hazards Models; D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis
D004966:Estrogens, Conjugated (USP); D008525:Medroxyprogesterone