A novel model for post-transplant obliterative airway disease reveals angiogenesis from the pulmonary circulation.
We present a novel animal model for post-transplant obliterative airway disease in which the donor trachea is implanted into the recipient's lung parenchyma. Although this procedure is technically more challenging than the heterotopic model of implantation into a subcutaneous pouch, it has several important advantages some of which are the appropriate local environment and the possibility of local immunosuppressive therapy after transtracheal gene, cell or drug delivery. This model has revealed new insights into angiogenic potential of the pulmonary circulation.
Dutly
Andre E
AE
Thoracic Surgery Research Laboratory, Toronto General Hospital Research Institute, Toronto, ON, Canada.
Andrade
Cristiano F
CF
Verkaik
Ryan
R
Kugathasan
Lakshmi
L
Trogadis
Judy
J
Liu
Mingyao
M
Waddell
Thomas K
TK
Stewart
Duncan J
DJ
Keshavjee
Shaf
S
D000818:Animals; D001989:Bronchiolitis Obliterans / Q000209:etiology; D004195:Disease Models, Animal; D008168:Lung / Q000601:surgery; D016040:Lung Transplantation; D009389:Neovascularization, Pathologic; D011652:Pulmonary Circulation; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D013997:Time Factors; D014132:Trachea / Q000637:transplantation