Antiviral and antimicrobial activities of new nitrobutane derivatives.
It is known that some addition products of beta-nitrostyrenes exhibit potent antimicrobial activity. In order to investigate the effects of structural modifications on the biological properties, some new Michael type addition products of beta-ethyl-beta-nitrostyrenes were synthesized. In this study, eight new 1-[(2-aminophenyl)thio]-1-phenyl-2-nitrobutane (2) derivatives were synthesized by addition of 2-aminothiophenol to the double bond of beta-ethyl-beta-nitrostyrenes (1). The chemical structures were proved by IR and 1H-NMR data and by elemental analysis. Antimicrobial activities of the synthesized compound were investigated against Escherichia coil, Pseudomonas aeruginosa, Proteus mirabilis, Enterococcus faecalis, Bacillus subtilis, Staphylococcus aureus, Candida albicans by the microdilution method. In addition, the newly synthesized compounds were studied for antiviral activities. All of them were found to be almost 100 fold more active than the standard compound aciclovir (CAS 59277-89-3).
Gökçe
Mehtap
M
Department of Pharmaceutical Chemistrya, Faculty of Pharmacy, Gazi University, Ankara, Turkey. mgokce@gazi.edu.tr
Ozçelik
Berrin
B
Bakir
Gökçen
G
Karaoğlu
Taner
T
Bergçin
Erdoğan
E
Noyanalpan
Ningur
N
D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002073:Butanes / Q000138:chemical synthesis*; D002522:Chlorocebus aethiops; D003470:Culture Media; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D014709:Vero Cells; D010948:Viral Plaque Assay
D000890:Anti-Infective Agents; D000998:Antiviral Agents; D002073:Butanes; D003470:Culture Media; D009574:Nitro Compounds; D010406:Penicillins; D000667:Ampicillin