The relationship between hippocampal EEG theta activity and locomotor behaviour in freely moving rats: effects of vigabatrin.
The relationship between hippocampal electroencephalogram (EEG) theta activity and locomotor speed in both spontaneous and forced walking conditions was studied in rats after vigabatrin injection (500 mg/kg i.p.). Vigabatrin increased the percentage of time that rats spent being immobile. During spontaneous walking in the open field, the speed of locomotion was increased by vigabatrin, while theta peak frequency was decreased. Vigabatrin also reduced the theta peak frequency during forced (speed controlled) walking. There was only a weak positive correlation (r=0.22) between theta peak frequency and locomotor speed for the saline condition. Furthermore, vigabatrin abolishes the weak relationship between speed of locomotion and theta peak frequency. Vigabatrin and saline did not differ in the slope of the regression line, but showed different offset points at the theta peak frequency axis. Thus, other factors than speed of locomotion seem to be involved in determination of the theta peak frequency.
Bouwman
B M
BM
NICI, Department Biological Psychology, Radboud University Nijmegen, P.O. Box 9104, 6500 HE Nijmegen, The Netherlands. B.Bouwman@nici.ru.nl
van Lier
H
H
Nitert
H E J
HE
Drinkenburg
W H I M
WH
Coenen
A M L
AM
van Rijn
C M
CM
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D013826:Theta Rhythm / Q000187:drug effects*; D020888:Vigabatrin / Q000494:pharmacology*; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D004791:Enzyme Inhibitors; D020888:Vigabatrin