title: Early suppression of disease activity is essential for maintenance of work capacity in patients with recent-onset rheumatoid arthritis: five-year experience from the FIN-RACo trial.
abstract: OBJECTIVE
  To explore the impact of an early treatment response on maintenance of work capacity in patients with early, active rheumatoid arthritis (RA).
  
  
  METHODS
  In the Finnish Rheumatoid Arthritis Combination Therapy trial, 195 patients with recent-onset RA were randomized to receive either a combination of disease-modifying antirheumatic drugs (DMARDs) with prednisolone or a single DMARD with or without prednisolone for 2 years. Treatment responses were evaluated according to the American College of Rheumatology (ACR) criteria. After a 5-year followup, the cumulative number of days of sick leave and RA-related permanent work disability was calculated for each of the 162 patients who were available for the active work force at baseline.
  
  
  RESULTS
  Of the 159 patients assessed at 6 months, 29 were in clinical remission, 66 achieved an ACR50 response but not remission, 29 achieved an ACR20 response but not an ACR50 response, and 35 failed to achieve an ACR20 response. In these 4 groups, the median numbers of work disability days per patient-year from 6 months through 60 months of followup were 0 (interquartile range [IQR] 0-3), 4 (IQR 0-131), 16 (IQR 0-170), and 352 (16-365), respectively (P < 0.001). Pairwise multiple comparisons showed a statistically significant difference between all groups except the ACR50 and ACR20 groups. At 12 months, 30 patients were in remission. None of the 44 patients in remission at 6 or 12 months became permanently work disabled over the 5-year followup, as compared with 15 patients in the ACR50 group (23%), 6 in the ACR20 group (21%), and 19 without an ACR20 response at 6 months (56%).
  
  
  CONCLUSIONS
  Prompt induction of remission translates into maintenance of work capacity. At 6 months, an ACR50 response is no better than an ACR20 response with regard to future productivity, while failure to achieve an ACR20 response carries a high risk for work disability.
authors.affiliation: Department of Medicine, Lappeenranta Central Hospital, Valto Käkelän katu 1, Lappeenranta FIN-53130, Finland. kari.puolakka@fimnet.fi
authors.forename: Kari
authors.initials: K
authors.lastname: Puolakka
authors.forename: Hannu
authors.initials: H
authors.lastname: Kautiainen
authors.forename: Timo
authors.initials: T
authors.lastname: Möttönen
authors.forename: Pekka
authors.initials: P
authors.lastname: Hannonen
authors.forename: Markku
authors.initials: M
authors.lastname: Korpela
authors.forename: Markku
authors.initials: M
authors.lastname: Hakala
authors.forename: Pentti
authors.initials: P
authors.lastname: Järvinen
authors.forename: Jari
authors.initials: J
authors.lastname: Ahonen
authors.forename: Sinikka
authors.initials: S
authors.lastname: Forsberg
authors.forename: Marjatta
authors.initials: M
authors.lastname: Leirisalo-Repo
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000503:physiopathology*; D004185:Disability Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*; D012074:Remission Induction; D018582:Sick Leave; D012460:Sulfasalazine / Q000627:therapeutic use; D013997:Time Factors; D014938:Work Capacity Evaluation
chemical_list: D000893:Anti-Inflammatory Agents; D018501:Antirheumatic Agents; D012460:Sulfasalazine; D006886:Hydroxychloroquine; D011239:Prednisolone; D008727:Methotrexate