Synthesis of some novel 6-benzyl(or substituted benzyl)-2-beta-D-glucopyranosyl-1,2,4-triazolo[4,3-b][1,2,4]triazines as potential antimicrobial chemotherapeutics.
Glucosidation of the new 8-amino-6-benzyl(or substituted benzyl)-2,8-dihydro-1,2,4-triazolo[4,3-b][1,2,4]triazin-7(3H)-ones (3a-d) with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide 4 gave the corresponding N-glucosides 5a-d. Chemical transformations leading to new functionalities have also been achieved to give compounds 7-12. Antimicrobial activity of compounds 5a-c against Aspergillus fumigatus, Penicillium italicum, Syncephalastrum racemosum, Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli is described.
Khalil
Nasser S A M
NS
Central Laboratory for Food and Feed, Agricultural Research Center, Giza, Egypt. Nasserkhalil_23@hotmail.com
Mansour
Abdel Kader
AK
Eid
Mohga M
MM
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005947:Glucose / Q000031:analogs & derivatives / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D014227:Triazines; D005947:Glucose