New beta-carboline alkaloids from the Andaman Sea sponge Dragmacidon sp.
Chemical investigation of the hithertho undescribed sponge Dragmacidon sp. from the Andaman Sea afforded two new beta-carboline alkaloids, which were named dragmacidonamines A (1) and B (2). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H detected direct, and long-range 13C-1H correlations) and mass spectrometric (EI and ESIMS) data. The 3-carboxylic-beta-carboline moiety and the thiomethylated imidazolinium unit as found in dragmacidonamines are very rarely encountered in nature.
Pedpradab
Suwigarn
S
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Edrada
RuAngelie
R
Ebel
Rainer
R
Wray
Victor
V
Proksch
Peter
P
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*
D000470:Alkaloids; D002243:Carbolines; C497311:dragmacidonamine A; C497312:dragmacidonamine B