[Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients].
OBJECTIVE
To explore factors influencing the effectiveness of immunosuppressive therapy in severe aplastic anemia (SAA).


METHODS
The serum levels of interleukin-2 (IL-2) and soluble IL-2 receptor (sIL-2R) of 22 SAA patients and 15 normal controls were measured by immunoenzyme assay.


RESULTS
Comparing with the normal controls, 40.9% and 63.6% of the SAA patients had higher serum levels of IL-2 (>840ng/L) and of sIL 2R (>320 x 10(3) U/L), respectively. Those who had higher IL-2 levels and higher sIL-2R levels got better responses to cyclosporin A(CsA) and CsA plus antilymphocyte globulin (ALG).


CONCLUSIONS
The serum levels of IL-2 and sIL-2R were correlated with the responsiveness to immunosuppressive therapy in SAA patients and might be useful for directing treatment.
Shao
Z
Z
Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.
Chen
K
K
Chen
G
G
Zhang
Y
Y
Wang
T
T
Zou
R
R
Zhou
X
X
Zhou
Y
Y
Chu
Y
Y
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood* / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007165:Immunosuppression Therapy; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood* / Q000737:chemistry*; D012189:Retrospective Studies; D012995:Solubility; D016896:Treatment Outcome; D055815:Young Adult
D007376:Interleukin-2; D015375:Receptors, Interleukin-2