title: Efficacy of intravenous diphenhydramine versus intravenous DHE-45 in the treatment of severe migraine headache.
abstract: This study was conducted to compare the efficacy of intravenous diphenhydramine with dihydroergotamine mesylate (DHE-45; Novartis International AG, Switzerland) in the treatment of severe, refractory, migraine headache. A retrospective review was conducted to include eighty randomly chosen patients who were admitted to the Michigan Head Pain & Neurological Institute's inpatient program at Chelsea Community Hospital. Patients had received nine doses of diphenhydramine or nine doses of DHE-45 during a 3-day period. Patients receiving DHE-45 also received metoclopramide (Reglan; AH Robins Company, Inc., Richmond, VA) as prophylaxis for nausea. Demographics, headache diagnosis, psychiatric discharge diagnoses, abortive medications, and adverse events were recorded and assessed.
authors.affiliation: Chelsea Community Hospital, Department of Pharmaceutical Care Services, 775 South Main Street, Chelsea, MI 48118, USA. sswidan@umich.edu
authors.forename: Sahar Z
authors.initials: SZ
authors.lastname: Swidan
authors.forename: Alvin E
authors.initials: AE
authors.lastname: Lake
authors.forename: Joel R
authors.initials: JR
authors.lastname: Saper
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use; D004087:Dihydroergotamine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004155:Diphenhydramine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000503:physiopathology*; D009325:Nausea / Q000517:prevention & control
chemical_list: D018712:Analgesics, Non-Narcotic; D000932:Antiemetics; D006634:Histamine H1 Antagonists; D004087:Dihydroergotamine; D004155:Diphenhydramine; D008787:Metoclopramide