New camptothecin and ellagic acid analogues from the root bark of Camptotheca acuminata.
As part of a study on chemical constituents of Camptotheca species, one new natural camptothecin analogue (2), two new alkaloids (3, 4), one new ellagic acid analogue (5), and 19 known compounds (1, 6-23) have been isolated from the root bark, stem bark, fruits, and leaves of Camptotheca acuminata Decaisne. The structures of 2-5 were determined from spectral data to be 10-methoxy-20-O-acetylcamptothecin (2), 20-O-beta-glucopyranosyl 18-hydroxycamptothecin (3), 20-formylbenz indolizino [1,2-b]quino-line-11(13H)-one (4), and 3,4-methylenedioxy-3'-O-methyl-5'-hydroxyellagic acid (5).
Zhang
Zhizhen
Z
Center for Medicinal Plant Research, Arthur Temple College of Forestry, Stephen F. Austin State University, Nacogdoches, Texas 75962-6109, USA.
Li
Shiyou
S
Zhang
Shanmin
S
Liang
Chun
C
Gorenstein
David
D
Beasley
R Scott
RS
D029769:Camptotheca; D002166:Camptothecin / Q000737:chemistry; D004610:Ellagic Acid / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots
D010936:Plant Extracts; D004610:Ellagic Acid; D002166:Camptothecin