A stereoselective three-component reaction: KAl(SO4)2.12H2O, an efficient and reusable catalyst for the one-pot synthesis of cis-isoquinolonic acids.
KAl(SO(4))(2).12H(2)O is found to catalyze efficiently the stereoselective one-pot three-component cyclocondensation of homophthalic anhydride, aldehydes, and amines under mild conditions to afford the corresponding cis-isoquinolonic acids in good yields.
Azizian
Javad
J
Department of Chemistry, Faculty of Science, Shahid Beheshti University, P.O. Box 19395-4716, Tehran, Iran. j-azizian@cc.sbu.ac.ir
Mohammadi
Ali A
AA
Karimi
Ali R
AR
Mohammadizadeh
Mohammad R
MR
D000447:Aldehydes / Q000737:chemistry; D017607:Aluminum Compounds / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D000812:Anhydrides / Q000737:chemistry; D002384:Catalysis; D007546:Isoquinolines / Q000138:chemical synthesis*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017680:Potassium Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013431:Sulfates / Q000737:chemistry*
D000447:Aldehydes; D017607:Aluminum Compounds; D000588:Amines; D000812:Anhydrides; D007546:Isoquinolines; C496295:KAl(SO4)2.12H2O; D017680:Potassium Compounds; D013431:Sulfates