Anti-adipogenic effects of Garcinia extract on the lipid droplet accumulation and the expression of transcription factor.
Garcinia extract was used as a potential anti-obesity agent. In this study, we found that Garcinia extract inhibits the cytoplasmic lipid accumulation as well as adipogenic differentiation of preadipocytes. The mechanisms that regulate the inhibition of insulin-induced differentiation by Garcinia extracts include the inhibition of expression of the early adipogenic transcription factor, CCAAT element binding protein (C/EBP)alpha that regulate adipogenesis. These results suggest that the specific targets of Garcinia extract on differentiation process of 3T3-L1 cells could be, at least, early adipogenic differentiation factor.
Kim
Myung-Sunny
MS
Korea Food Research Institute, Songnam, Kyongki-do, South Korea. truka@kfri.re.kr
Kim
Jin-Kyung
JK
Kwon
Dae-Young
DY
Park
Raekil
R
D016475:3T3 Cells; D017667:Adipocytes / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D019440:Anti-Obesity Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D029761:Garcinia cambogia; D005786:Gene Expression Regulation / Q000187:drug effects; D050356:Lipid Metabolism; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D014157:Transcription Factors / Q000187:drug effects / Q000235:genetics*
D019440:Anti-Obesity Agents; D010936:Plant Extracts; D014157:Transcription Factors