title: Optimal control of coupled spin dynamics: design of NMR pulse sequences by gradient ascent algorithms.
abstract: In this paper, we introduce optimal control algorithm for the design of pulse sequences in NMR spectroscopy. This methodology is used for designing pulse sequences that maximize the coherence transfer between coupled spins in a given specified time, minimize the relaxation effects in a given coherence transfer step or minimize the time required to produce a given unitary propagator, as desired. The application of these pulse engineering methods to design pulse sequences that are robust to experimentally important parameter variations, such as chemical shift dispersion or radiofrequency (rf) variations due to imperfections such as rf inhomogeneity is also explained.
authors.affiliation: Division of Applied Sciences, Harvard University, Cambridge, MA 02138, USA. navin@hrl.harvard.edu
authors.forename: Navin
authors.initials: N
authors.lastname: Khaneja
authors.forename: Timo
authors.initials: T
authors.lastname: Reiss
authors.forename: Cindie
authors.initials: C
authors.lastname: Kehlet
authors.forename: Thomas
authors.initials: T
authors.lastname: Schulte-Herbrüggen
authors.forename: Steffen J
authors.initials: SJ
authors.lastname: Glaser
mesh_terms: D000465:Algorithms; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*