Copper-free sonogashira coupling reaction with PdCl2 in water under aerobic conditions.
A mild protocol for the copper-free Sonogashira coupling of aryl iodides with terminal acetylenes in water under aerobic conditions has been developed. The use of 1 mol % PdCl(2) in the presence of pyrrolidine allows the coupling reaction to proceed at room temperature or 50 degrees C with good to excellent yields.
Liang
Bo
B
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Beijing 100871, China.
Dai
Mingji
M
Chen
Jiahua
J
Yang
Zhen
Z