HIV treatment models with time delay.
The present paper shows possible effects of antiretroviral treatment on the dynamics of the spread of the disease of human immunodeficiency virus infection in a population of varying size. By introducing time delays, we model the latency period and the delayed onset of positive treatment effects in the patients. The Hopf bifurcation and stability behaviour of the delay differential-equation model are analysed and simulations for different scenarios depending on the size of the treatment-induced delay are presented, and the results are discussed in detail.
Bachar
Mostafa
M
Institute for Mathematics, University of Graz, Heinrichstrasse 36, 8010 Graz, Austria. mostafa.bachar@uni-graz.at
Dorfmayr
Anita
A
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D018655:Lymphocyte Count; D008433:Mathematics; D008954:Models, Biological; D013997:Time Factors
D019380:Anti-HIV Agents