title: Antidepressant xerogenic medications and restoration rates.
abstract: OBJECTIVE
  This report examines the association between xerogenic antidepressant medication use and dental restorations (a proxy for dental caries).
  
  
  METHODS
  Data for this study was collected from the electronic databases of two large dental group practices associated with two managed care organizations. The population examined was at least 55-year-old on the reference date and had at least 48 months of concurrent dental, medical and pharmacy coverage. We identified 915 individuals whose only exposure to a xerogenic medication was to an antidepressant. This group was compared with a group not on any medications and to a group on medications without any known xerostomic side effect.
  
  
  RESULTS
  Poisson regression was used to compare restoration occurrence and restoration rates among the three groups. The antidepressant medication and the no xerogenic medication groups were more likely to have restorations than the no medication group but there was no difference in restoration rates between the two medication groups. The mean restoration rates were significantly different between the three groups with the antidepressant group having the highest restoration rate. The no xerogenic group also had a higher rate than the no medication group but not as high as the antidepressant group rate.
  
  
  CONCLUSIONS
  This study provides objective quantification of the long-term effects that anti-depressant medications have on restoration use.
authors.affiliation: HealthPartners Research Foundation, 8100 34th Avenue S., Bloomington, MN 55425, USA. d.brad.rindal@healthpartners.com
authors.forename: D Brad
authors.initials: DB
authors.lastname: Rindal
authors.forename: William A
authors.initials: WA
authors.lastname: Rush
authors.forename: Dawn
authors.initials: D
authors.lastname: Peters
authors.forename: Gerardo
authors.initials: G
authors.lastname: Maupomé
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D003731:Dental Caries / Q000209:etiology*; D003793:Dental Restoration, Permanent / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D014987:Xerostomia / Q000139:chemically induced / Q000150:complications
chemical_list: D000928:Antidepressive Agents