Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study.
In an exploratory study, 11 common polymorphisms were examined for contributing to longevity including: apolipoprotein E (apoE), methylenetetrahydrofolate reductase (MTHFR), cathepsin D (CAD), superoxide dismutase 2 (SOD2), angiotensinogen (AGT) and insulin-like growth factor 2 (IGF2), Leiden factor 7, p53 oncogene, dopamine D4 receptor (DRD4) and the serotonin transporter (SERT). Genotype and allele frequencies of these genes were compared in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity to a group of 441 younger subjects (22 years). Nominally significant results provide suggestive evidence in the Ashkenazi group that apoE, MHTFR, SOD2, IGF2 ApaI, and factor VII are risk factors for a single outcome, survival to 75. Overall, the more genetically homogenous Ashkenazi ethnic group showed evidence for association in five genes examined suggesting that future studies in this population would gainfully focus on this ethnic group.
Stessman
Jochanan
J
Department of Geriatric Rehabilitation, Hadassah Hospital, Hebrew University Medical Center, Mt. Scopus, Jerusalem.
Maaravi
Yoram
Y
Hammerman-Rozenberg
Robert
R
Cohen
Aaron
A
Nemanov
Lubov
L
Gritsenko
Inga
I
Gruberman
Nelly
N
Ebstein
Richard P
RP
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000208:ethnology / Q000235:genetics*; D000808:Angiotensinogen / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics; D002402:Cathepsin D / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D005167:Factor VII / Q000235:genetics; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D007557:Israel; D008017:Life Expectancy; D008136:Longevity / Q000235:genetics*; D008137:Longitudinal Studies; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D026901:Membrane Transport Proteins / Q000235:genetics; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050638:Receptors, Dopamine D4; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins; D013482:Superoxide Dismutase / Q000235:genetics; D000099156:Superoxide Dismutase 2
D000808:Angiotensinogen; D001057:Apolipoproteins E; D002402:Cathepsin D; D017931:DNA Primers; D005167:Factor VII; D007328:Insulin; D007335:Insulin-Like Growth Factor II; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009419:Nerve Tissue Proteins; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D050486:Serotonin Plasma Membrane Transport Proteins; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2; C493599:DRD4 protein, human; C493230:SLC6A4 protein, human