Brain plasticity and antidepressant treatments: new cells, new connections.
It is now a decade since we first wrote about the impact of antidepressant agents on plastic processes in the hippocampus (Stewart and Reid, 1993). Since then, the roles of various forms of brain plasticity have moved centre stage in efforts to understand the pathophysiology of depressive disorder. Here, we review the background to current views relating cytoarchitectural and synaptic changes to the aetiology and treatment of affective disease.
Reid
Ian C
IC
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.
Stewart
Caroline A
CA
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000166:cytology / Q000254:growth & development*; D003071:Cognition / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009414:Nerve Growth Factors / Q000494:pharmacology; D009473:Neuronal Plasticity / Q000187:drug effects*; D013315:Stress, Psychological / Q000503:physiopathology; D013569:Synapses / Q000187:drug effects / Q000502:physiology
D000928:Antidepressive Agents; D009414:Nerve Growth Factors