title: Magnetic resonance imaging and surgical repair of cleft palate in a four-week-old canine (Canis familiaris): an animal model for cleft palate repair.
abstract: Successful cleft palate repair (palatoplasty) was accomplished in a male canine pup from a kindred with autosomal recessive transmission for a complete cleft palate phenotype. This case represents the potential application of a new animal model for cleft palate repair. This reproducible congenital defect provides a clinically relevant model to improve research into the human anomaly, as compared with previous iatrogenic or teratogenically induced animal models. This case report presents the basis for new repair techniques and for studying the genetic basis of the cleft palate defect.
authors.affiliation: Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Ravi
authors.initials: R
authors.lastname: Tolwani
authors.forename: Catherine
authors.initials: C
authors.lastname: Hagan
authors.forename: Jonathan
authors.initials: J
authors.lastname: Runstadler
authors.forename: Heather
authors.initials: H
authors.lastname: Lyons
authors.forename: Sherril
authors.initials: S
authors.lastname: Green
authors.forename: Donna
authors.initials: D
authors.lastname: Bouley
authors.forename: Luis
authors.initials: L
authors.lastname: Rodriguez
authors.forename: Stephen
authors.initials: S
authors.lastname: Schendel
authors.forename: Michael
authors.initials: M
authors.lastname: Moseley
authors.forename: David
authors.initials: D
authors.lastname: Daunt
authors.forename: Glen
authors.initials: G
authors.lastname: Otto
authors.forename: Linda
authors.initials: L
authors.lastname: Cork
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002972:Cleft Palate / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D004285:Dogs; D008279:Magnetic Resonance Imaging; D008297:Male; D019647:Oral Surgical Procedures / Q000379:methods*; D019651:Plastic Surgery Procedures / Q000379:methods*; D016896:Treatment Outcome