[Telomere and cancer: what's more at the end?].
Telomeres are nucleoprotein complexes that cap the end of eukaryotic chromosomes. They are essential for the functions and the stability of the genomes. There is now compelling evidences that telomerase, the enzyme that adds telomeric DNA repeats to chromosome end, is an important player in oncogenesis. The absence of telomerase in somatic tissues is thought to promote genome instability at initial stages of oncogenesis, favoring the emergence of cancer-associated chromosomal abnormalities \; restablishment of telomerase activity is expected afterwards if long term cell cycling is to occur. In addition to telomerase, various factors control the structure and function of telomeres, suggesting that additional telomeric components play important roles during oncogenesis.
Brunori
Michele
M
Laboratoire de Biologie moléculaire de la cellule, UMR 5161, CNRS, Ecole normale supérieure de Lyon, 46, allée d'Italie, 69364 Lyon Cedex 07, France. Eric.Gilson@ens-lyon.fr
Gilson
Eric
E
D002875:Chromosomes / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics*; D019098:Telomerase / Q000235:genetics; D016615:Telomere
D019098:Telomerase