title: Aberrant expression of platelet-derived growth factor (PDGF) and PDGF receptor-alpha is associated with advanced bone marrow fibrosis in idiopathic myelofibrosis.
abstract: The expression of members of the platelet-derived growth factor (PDGF) system in bone marrow cells derived from Idiopathic myelofibrosis (IMF) has been investigated by real-time RT-PCR. Increased expression of PDGFs and the corresponding PDGF receptor a could be demonstrated to be a feature of advanced fibrosis in IMF that is not demonstrable in the prefibrotic phase of the disease.
authors.forename: Oliver
authors.initials: O
authors.lastname: Bock
authors.forename: Gero
authors.initials: G
authors.lastname: Loch
authors.forename: Guntram
authors.initials: G
authors.lastname: Büsche
authors.forename: Reinhard
authors.initials: R
authors.lastname: von Wasielewski
authors.forename: Jerome
authors.initials: J
authors.lastname: Schlué
authors.forename: Hans
authors.initials: H
authors.lastname: Kreipe
mesh_terms: D018450:Disease Progression; D015870:Gene Expression; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000737:chemistry / Q000235:genetics*; D055728:Primary Myelofibrosis / Q000235:genetics*; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000737:chemistry / Q000235:genetics*
chemical_list: D010982:Platelet-Derived Growth Factor; D020033:Protein Isoforms; D020796:Receptor, Platelet-Derived Growth Factor alpha