Validity and reliability of a French version of the MRF-28 health-related quality of life questionnaire.
BACKGROUND
Evaluation of health-related quality of life (HRQL) in chronic respiratory failure (CRF) is an important issue for evaluating the impact of treatment.


OBJECTIVE
To elaborate a French version of the Maugeri Foundation Respiratory Failure Questionnaire (MRF-28) disease-specific HRQL questionnaire and determine its validity and reliability in patients with CRF treated by home mechanical ventilation (HMV).


METHODS
Forward- and back-translation of the MRF-28 questionnaire; the final version was submitted to 81 patients treated with HMV for CRF, simultaneously with the St. George's Respiratory Questionnaire (SGRQ), the Short Form 36 (SF-36), and the Hospital Anxiety and Depression scale (HAD). Validity was determined by correlation with previously validated HRQL scores and recorded physiological parameters. Reliability was evaluated by assessing internal consistency and test-retest stability of the MRF-28 scores.


RESULTS
The French version of the MRF-28 and its subscores ('daily activity', 'cognitive function', and 'invalidity') were highly significantly correlated with subscores of the SGRQ, the SF-36 and the HAD. Both the MRF-28 and the SGRQ were correlated only with age and the 6-min walk test. The MRF-28 showed high test-retest reliability after 2 weeks (r2 = 0.80, p < 0.0001) and high internal consistency (Crohnbachs' alpha coefficient: 0.91).


CONCLUSIONS
The French version of the MRF-28 is a valid and reliable disease-specific questionnaire for assessing HRQL in patients with CRF.
Janssens
Jean-Paul
JP
Division of Pulmonary Diseases, Geneva University Hospital, Geneva, Switzerland. Jean-Paul.Janssens@hcuge.ch
Héritier-Praz
Anne
A
Carone
Mauro
M
Burdet
Luc
L
Fitting
Jean-William
JW
Uldry
Christophe
C
Tschopp
Jean-Marie
JM
Rochat
Thierry
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D015203:Reproducibility of Results; D012131:Respiratory Insufficiency; D011795:Surveys and Questionnaires