Secondary erythrocytosis associated with schwannoma in a dog.
An 11-year-old, spayed female mixed-breed dog showed clinical signs of right forelimb lameness and pain by palpation around the neck. Radiography and computed tomography (CT) revealed an extradural mass at the 6th and 7th cervical vertebrae, which compressed the spinal cord. The mass was surgically removed and histopathologically diagnosed as schwannoma. The dog recovered her normal gait after hemilaminectomy and removal of the mass. Ten months after the surgery, the tumor recurred with absolute erythrocytosis and was surgically removed again. This removal temporarily resolved the erythrocytosis with a decrease in plasma erythropoietin (EPO) concentration. EPO protein was detected immunohistochemically in the tumor cells. Erythrocytosis in this dog may be caused by ectopic EPO produced in the schwannoma tissues.
Yamauchi
Akiko
A
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Ohta
Tamiko
T
Okada
Taro
T
Mochizuki
Manabu
M
Nishimura
Ryohei
R
Matsunaga
Satoru
S
Nakayama
Hiroyuki
H
Doi
Kunio
K
Sasaki
Nobuo
N
D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004921:Erythropoietin / Q000097:blood; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D007150:Immunohistochemistry / Q000662:veterinary; D009442:Neurilemmoma / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery / Q000662:veterinary*; D010524:Peripheral Nervous System Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery / Q000662:veterinary*; D011086:Polycythemia / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D011859:Radiography; D013126:Spinal Nerve Roots / Q000000981:diagnostic imaging
D004921:Erythropoietin