title: Gene-nutrient interactions in cancer etiology.
abstract: Relationships between dietary components and cancer risk are often unclear, and the results from epidemiologic studies are inconsistent. While some inconsistencies could be due to study design issues, we propose that genetic heterogeneity of study populations could mask associations. In this report, we review the literature regarding meat consumption and risk of colon, breast, and prostate cancers, particularly in relation to phenotypes and genotypes for enzymes that metabolize food-borne promutagens. The role of consumption of fruits and vegetables, as well as the role of genetic variants in oxidative stress genes, in the risk of breast cancer are also discussed.
authors.affiliation: Department of Epidemiology, Roswell Park Cancer Institute, Elm Street, Buffalo, NY 14263, USA.
authors.forename: Susan A
authors.initials: SA
authors.lastname: Nowell
authors.forename: Jiyoung
authors.initials: J
authors.lastname: Ahn
authors.forename: Christine B
authors.initials: CB
authors.lastname: Ambrosone
mesh_terms: D002273:Carcinogens / Q000008:administration & dosage / Q000009:adverse effects; D004032:Diet; D005638:Fruit; D020022:Genetic Predisposition to Disease; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects; D008460:Meat / Q000009:adverse effects; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics*; D009602:Nitrosamines / Q000008:administration & dosage / Q000009:adverse effects; D014675:Vegetables
chemical_list: D002273:Carcinogens; D007093:Imidazoles; D009602:Nitrosamines; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine