The interaction between levofloxacine hydrochloride and DNA mediated by Cu2+.
Levofloxacin (LEV) is a fluoroquinolone antimicrobial agent. LEV also inhibits DNA synthesis and is bactericidal. The mechanisms of the interaction among LEV, DNA and Cu2+ are studied by fluorescence method. In the paper, the results show that LEV and Cu2+ can form binary complex, and also LEV and DNA can form complex mediated by Cu2+. The composition of the complex is determined. The affects to the reaction are also found.
Song
Gongwu
G
Faculty of Chemistry and Material Science, Hubei University, Wuhan 430062, People's Republic of China. songgw@hubu.edu.cn
He
Yu
Y
Cai
Zhaoxia
Z
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D002417:Cattle; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D066298:In Vitro Techniques; D064704:Levofloxacin; D009691:Nucleic Acid Denaturation; D015242:Ofloxacin / Q000737:chemistry*; D009994:Osmolar Concentration; D013050:Spectrometry, Fluorescence; D013696:Temperature
D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D003300:Copper; D004247:DNA; D015242:Ofloxacin