Case report: a common presentation of a rare disease-hepatosplenic T-cell lymphoma.
Hepatosplenic T-cell lymphoma is a rare neoplasm characterized by systemic B-symptoms, hepatosplenomegaly, no lymphadenopathy, and lymphomatous infiltrates in the splenic red pulp, hepatic sinusoids, and bone marrow sinuses. The team presents the case of a healthy 30 year old man, active duty Marine, who presented with classic symptoms, yet obtaining a diagnosis took over three months from the onset of symptoms. This clinical entity initially described in 1990, is elusive, with vague and misleading symptoms. Despite aggressive conventional therapy with anthracycline-based regimens and stem cell transplant, prognosis is poor and median survival is less than one year
Munir
Jamalah
J
US Army, Medical Corps, Tripler Army Medical Center, Honolulu, Hawaii 96859, USA. jamalah.munir@haw.tamc.amedd.army.mil
Preston
Glenn
G
Polish
Roger
R
D000328:Adult; D003937:Diagnosis, Differential; D006254:Hawaii; D006529:Hepatomegaly; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011859:Radiography; D013160:Splenic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D013163:Splenomegaly