title: Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
abstract: The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.
authors.affiliation: Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamada
authors.forename: Koji
authors.initials: K
authors.lastname: Yazawa
authors.forename: Akira
authors.initials: A
authors.lastname: Shimizu
authors.forename: Takehiro
authors.initials: T
authors.lastname: Iwanaga
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Hisashi
authors.forename: Matthew
authors.initials: M
authors.lastname: Nuhn
authors.forename: Patricia
authors.initials: P
authors.lastname: O'Malley
authors.forename: Shuji
authors.initials: S
authors.lastname: Nobori
authors.forename: Parsia A
authors.initials: PA
authors.lastname: Vagefi
authors.forename: Clive
authors.initials: C
authors.lastname: Patience
authors.forename: Jay
authors.initials: J
authors.lastname: Fishman
authors.forename: David K C
authors.initials: DK
authors.lastname: Cooper
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hawley
authors.forename: Julia
authors.initials: J
authors.lastname: Greenstein
authors.forename: Henk-Jan
authors.initials: HJ
authors.lastname: Schuurman
authors.forename: Michel
authors.initials: M
authors.lastname: Awwad
authors.forename: Megan
authors.initials: M
authors.lastname: Sykes
authors.forename: David H
authors.initials: DH
authors.lastname: Sachs
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D003404:Creatinine / Q000378:metabolism; D004187:Disaccharides / Q000276:immunology / Q000378:metabolism; D005700:Galactosyltransferases / Q000235:genetics* / Q000378:metabolism; D016030:Kidney Transplantation; D010215:Papio; D013552:Swine; D013950:Thymus Gland / Q000637:transplantation*; D013997:Time Factors; D014183:Transplantation, Heterologous / Q000276:immunology
chemical_list: D004187:Disaccharides; C055075:galactosyl-(1-3)galactose; D003404:Creatinine; D005700:Galactosyltransferases