Preparation of 2-pyridone-containing tricyclic alkaloid derivatives as potential inhibitors of tumor cell proliferation by regioselective intramolecular N- and C-acylation of 2-pyridone.
A novel and practical preparation of 2-pyridone-containing tricyclic alkaloid derivatives was developed. By regioselective intramolecular N- and C-acylation of 2-(4-aryl-2-pyridon-6-yl)benzoic acid, a pair of structural isomers 2-aryl pyrido[2,1-a]isoindole-4,6-diones and 4-aryl 1-methyl-1H-indeno[1,2-b]-pyridine-2,5-diones, as potential inhibitors of tumor cell proliferation, were prepared respectively.
Wang
Shaozhong
S
Department of Chemistry, Nanjing University, Nanjing, P. R. China.
Cao
Liya
L
Shi
Haijian
H
Dong
Yanmei
Y
Sun
Jianwei
J
Hu
Yuefei
Y
D000215:Acylation / Q000187:drug effects; D000470:Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011728:Pyridones / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism
D000470:Alkaloids; D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D011728:Pyridones; C017679:2-hydroxypyridine