title: Non-nucleoside structures retain full anti-HCMV potency of the dideoxy furanopyrimidine family.
abstract: We have recently reported that 2',3'dideoxy analogues of our exquisitely potent anti-VZV furanopyrimidine deoxynucleosides are shifted to selective anti-HCMV agents. We now find that the fully deoxygenated 2',3',5'-trideoxy analogue is fully antivirally active. This is taken as proof that these agents act by a novel non-nucleoside mechanism of action.
authors.affiliation: Welsh School of Pharmacy, Cardiff University, Cardiff, UK. bideto@cardiff.ac.uk
authors.forename: Olivier
authors.initials: O
authors.lastname: Bidet
authors.forename: Christopher
authors.initials: C
authors.lastname: McGuigan
authors.forename: Robert
authors.initials: R
authors.lastname: Snoeck
authors.forename: Graciela
authors.initials: G
authors.lastname: Andrei
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects*; D015224:Dideoxynucleosides / Q000737:chemistry / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry*; D006801:Humans; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D015224:Dideoxynucleosides; D005663:Furans; D011741:Pyrimidine Nucleosides