Enantioselective tandem michael addition/H2-hydrogenation catalyzed by ruthenium hydride borohydride complexes containing beta-aminophosphine ligands.
A variety of ruthenium(II) catalyst precursors containing beta-aminophosphine ligands and a borohydride ligand were found to be active for a one-pot, tandem asymmetric Michael addition/H2-hydrogenation reaction to give the chiral alcohol in excellent diastereomeric excess. The most effective catalyst is 4b, containing the (S)-binap ligand and (R,R)-Pnor ligand, derived from (1S,2R)-norephedrine.
Guo
Rongwei
R
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
Morris
Robert H
RH
Song
Datong
D