title: Antidiabetic coumarin and cyclitol compounds from Peucedanum japonicum.
abstract: The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix (Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclitol as active principles, that is, peucedanol 7-O-beta-D-glucopyranoside (1) and myo-inositol (2). Their structures were identified by spectroscopic methods. Compound 1 showed 39% inhibition of postprandial hyperglycemia at 5.8 mg/kg dose, and compound 2 also significantly inhibited postprandial hyperglycemia by 34% (P<0.05).
authors.affiliation: Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon, Gyeonggi-Do 440-746, Korea.
authors.forename: Sung Ok
authors.initials: SO
authors.lastname: Lee
authors.forename: Sang Zin
authors.initials: SZ
authors.lastname: Choi
authors.forename: Jong Hwa
authors.initials: JH
authors.lastname: Lee
authors.forename: Sung Hyun
authors.initials: SH
authors.lastname: Chung
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Park
authors.forename: Hee Chol
authors.initials: HC
authors.lastname: Kang
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Yang
authors.forename: Hi Jae
authors.initials: HJ
authors.lastname: Cho
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000818:Animals; D019661:Apiaceae; D001786:Blood Glucose / Q000187:drug effects / Q000502:physiology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots
chemical_list: D001786:Blood Glucose; D003374:Coumarins; D007004:Hypoglycemic Agents; D010936:Plant Extracts; C030123:coumarin