title: [Roles of Toll-like receptor in host defense and the mechanism of its signal transduction].
authors.affiliation: Department of Host Defense, Research Institute for Microbial Diseases, Osaka University.
authors.forename: Osamu
authors.initials: O
authors.lastname: Takeuchi
authors.forename: Shizuo
authors.initials: S
authors.lastname: Akira
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000502:physiology; D033942:Adaptor Proteins, Vesicular Transport / Q000737:chemistry / Q000502:physiology; D000818:Animals; D000943:Antigens, Differentiation / Q000737:chemistry / Q000502:physiology; D001419:Bacteria / Q000276:immunology; D053592:Interleukin-1 Receptor-Associated Kinases; D008024:Ligands; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D053594:Myeloid Differentiation Factor 88; D011494:Protein Kinases / Q000502:physiology; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000276:immunology / Q000502:physiology*; D011971:Receptors, Immunologic / Q000737:chemistry / Q000502:physiology; D017472:Receptors, Interleukin-1 / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics; D051193:Toll-Like Receptors; D014780:Viruses / Q000276:immunology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D000943:Antigens, Differentiation; D008024:Ligands; C507779:MYD88 protein, human; D008562:Membrane Glycoproteins; D053594:Myeloid Differentiation Factor 88; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; C470409:TICAM1 protein, human; C480228:TICAM2 protein, human; D051193:Toll-Like Receptors; D011494:Protein Kinases; D053592:Interleukin-1 Receptor-Associated Kinases