[Effect of the sustained release excipients on the release rate of ginsenoside Rg1 and ginsenoside Rb1 in sustained-release tablet of Panax notoginsenosides].
OBJECTIVE
To study the influence of the sustained release excipient on the release rate of ginsenoside Rg1 and ginsenoside Rb1 in sustained-release tablet of Panax Notoginsenosides.


METHODS
The release rate of ginsenoside Rg1 and ginsenoside Rb1 in different matrix tablets with different excipient (HPMC, EC), different viscosity of EC (RT-50, RT-100), different ratio of EC in matrix tablet were detected.


RESULTS
All above different factors influence the release rate of ginsenoside Rg1 and ginsenoside Rb1 and brought them different release curve.


CONCLUSIONS
Emphasis should be laid on the different release characteristic of different active compounds in active fraction.
Wu
Qing
Q
Beijing University of Chinese Medicine, Beijing 100102, China. qwu@vip.sina.com
Chen
Xian-chun
XC
Du
Shou-ying
SY
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005079:Excipients / Q000737:chemistry*; D036145:Ginsenosides / Q000737:chemistry*; D007785:Lactose / Q000031:analogs & derivatives* / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D010078:Oxazines; D005894:Panax; D010946:Plants, Medicinal; D013607:Tablets
D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D005079:Excipients; D036145:Ginsenosides; D010078:Oxazines; D013607:Tablets; C442759:ginsenoside Rb1; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose; C035054:ginsenoside Rg1