The effects of 2% ibopamine eye drops on the intraocular pressure and pupil motility of patients with open-angle glaucoma.
OBJECTIVE
Ibopamine is a prodrug of N-methyldopamine that has a non-cycloplegic mydriatic action due to its alpha-adrenergic properties and is able to induce, when topically given, a transient increase of intraocular pressure (IOP) in eyes with hydrodynamic disorders.


METHODS
This is a randomized, crossover, open-labeled, two- center study. Forty patients (20 open-angle glaucoma patients and 20 healthy subjects) were treated with ibopamine 2% eye drops and phenylephrine 10% eye drops.


RESULTS
Ibopamine induced a significant increase in IOP only in glaucomatous eyes (p<0.001) without a significant hypertensive effect in normal eyes. Ibopamine and phenylephrine showed a similar mydriatic activity but ibopamine was able to induce an hypertensive effect only in glaucomatous eyes.


CONCLUSIONS
The results confirm the use of ibopamine as provocative test in detection of hydrodynamic disorders.
Giuffrè
I
I
Neurosciences Department, La Sapienza University, Roma - Italy. italogiuffre@virgilio.it
Taverniti
L
L
Di Staso
S
S
D000287:Administration, Topical; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D018592:Cross-Over Studies; D003846:Deoxyepinephrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009184:Mydriatics / Q000008:administration & dosage / Q000494:pharmacology*; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000494:pharmacology; D010656:Phenylephrine / Q000008:administration & dosage / Q000627:therapeutic use; D011680:Pupil / Q000187:drug effects*; D014065:Tonometry, Ocular
D000959:Antihypertensive Agents; D009184:Mydriatics; D009883:Ophthalmic Solutions; D010656:Phenylephrine; C023487:ibopamine; D003846:Deoxyepinephrine