title: Pathological study of bronchospasms/tracheomalasia in patients with severe motor and intellectual disabilities.
abstract: This report concerns two autopsy cases of severe motor and intellectual disabilities (SMID) who died of bronchospasms or tracheomalasia. One case had no anatomical change in the tracheal wall except for an endotracheal granuloma, while the other showed softening of the tracheal wall. Since patients with SMID have risk factors for bronchospasms and tracheomalasia, such as gastro-esophageal reflux, aspiration, and thoracic deformities, it is important that we suspect the possibility of these conditions, when we see the respiratory distress in cases of SMID.
authors.affiliation: Department of Pediatrics, Metropolitan Fuchu Medical Center for Severe Motor and Intellectual Disabilities, 2-9-2, Musashidai, Fuchu-shi, Tokyo 183-0042, Japan. eitsuru@yahoo.co.jp
authors.forename: Eiko
authors.initials: E
authors.lastname: Ohtsuka
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hayashi
authors.forename: Kimiko
authors.initials: K
authors.lastname: Hamano
authors.forename: Satoko
authors.initials: S
authors.lastname: Kumada
authors.forename: Akira
authors.initials: A
authors.lastname: Uchiyama
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Kurata
authors.forename: Makiko
authors.initials: M
authors.lastname: Osawa
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D001986:Bronchial Spasm / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D017809:Fatal Outcome; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006099:Granuloma / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009069:Movement Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D009421:Nervous System Malformations / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D011015:Pneumonia, Aspiration / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D013577:Syndrome; D014132:Trachea / Q000473:pathology* / Q000503:physiopathology