Suppressive activity of a fermented grain food product on dextran sulfate sodium-induced experimental colitis in mice.
Oxidative stress has been shown to play pivotal roles in the onset of inflammatory bowel disease. We evaluated the effects of a dietary anti-oxidant, Antioxidant Biofactor (AOB), a processed grain food, on dextran sulfate sodium (DSS)-induced colitis in mice. Female ICR mice were fed a diet containing 0.1% or 1% AOB for 2 weeks, during which they were given 5% DSS in drinking water for the latter 1 week to induce colitis. A diet containing 1% AOB, but not that with 0.1% AOB, attenuated DSS-induced body weight loss and colon shortening (each, P < 0.05), and dramatically improved colitis histologic scores. In addition, DSS-induced increases in colonic mucosal IL-1beta, but not TNF-alpha, protein levels were significantly abrogated in 1% AOB-fed mice (P < 0.05). Further, 1% dietary AOB abolished the expression of IL-1beta mRNA levels in colonic mucosa (P < 0.01). Our results suggest that AOB is effective for the prevention of DSS-induced colitis in mice.
Kwon
K H
KH
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Murakami
A
A
Tanaka
T
T
Ohigashi
H
H
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000139:chemically induced* / Q000517:prevention & control*; D016264:Dextran Sulfate / Q000633:toxicity*; D004195:Disease Models, Animal; D002523:Edible Grain; D005260:Female; D005285:Fermentation; D007375:Interleukin-1 / Q000032:analysis; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000975:Antioxidants; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D016264:Dextran Sulfate