Protein tyrosine phosphatases and their inhibitors.
Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.
Dewang
Purushottam M
PM
Department of Chemistry, National Central University, Chung Li, Taiwan 32054, Republic of China.
Hsu
Nai-Mu
NM
Peng
Shao-Zheng
SZ
Li
Wen-Ren
WR
D000818:Animals; D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000145:classification / Q000502:physiology; D015398:Signal Transduction
D004791:Enzyme Inhibitors; D017027:Protein Tyrosine Phosphatases