Endolymphatic infusion: human surgical investigation and application.
The ability to influence changes within the lymphatic system, and to exert a therapeutic influence on the composition and quality of the lymph, may have a substantial impact on the therapeutic outcome in disease interventions. This report concerns our experience with endolymphatic infusion (ELI) of drugs, an approach that we have utilized in a surgical context to destroy bacteria within lymphatic vessels and lymph nodes. Experimentally, we have demonstrated that a variety of antibiotics will temporarily decrease the contractile activity of the lymphatic vessels and reduce the volume of lymph flow. Based on our initial observations, we have applied endolymphatic infusion to clinical care. ELI was evaluated in the treatment of 330 patients, utilizing protocols to alter the characteristics of lymph flow.
Petrov
S
S
Department of Surgery, St Petersburg State University, St Petersburg, Russia. PSVsurg@mail.ru
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002404:Catheterization; D016503:Drug Delivery Systems; D006801:Humans; D007272:Injections, Intralymphatic / Q000379:methods*; D008196:Lymph / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology*; D008208:Lymphatic System / Q000187:drug effects / Q000502:physiology*; D042601:Lymphatic Vessels / Q000187:drug effects / Q000382:microbiology; D008220:Lymphography; D011343:Procaine / Q000494:pharmacology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D011343:Procaine