[Study on relationship of soluble interleukin-2 receptors in serious hepatitis B patients and the T lymphocyte subgroup].
The assay of sIL-2R and T lymphocyte subgroup in 21 cases of serious HB patients revealed that serum sIL-2R in patients of acute and subacute or chronic serious HB was significantly higher than those in normal controls, P<0.001, but the CD4+ lymphocytes in all these patients obviously decreased and CD8+ lymphocytes notably increased when compared with that in normal group, P<0.01. The results showed that increasing of sIL-2R is associated with the activation of CD8+ cells which is mainly of cytotoxicity T lymphoeytes that play an important role in the pathogenesis of acute and subacute serious HB. The different expression of CD4+ and CD8+ in acute and chronic serious HB suggests a different pathogenetic mechanism between them.
Zhang
P
P
Harbin Hospital of Infectious Diseases 150030.
Wei
F
F
Jiao
W
W
Yang
Y
Y
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D015375:Receptors, Interleukin-2