Reduction of beta-hydroxyketones by SmI2/H2O/Et3N.
Reduction of a series of beta-hydroxyketones by SmI2/H2O/Et3N provided 1,3-diols in quantitative yields. The reactions were exceedingly clean with no byproduct formation, negating the need for further purification. Most reactions provided moderate to excellent diastereoselectivity with syn-diols as the major isomer in most instances.
Davis
Todd A
TA
Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, Texas 79409, USA.
Chopade
Pramod R
PR
Hilmersson
Göran
G
Flowers
Robert A
RA