[Effects of stress agents and heparin administration on hematological parameters in Wistar rats].
In chronic experiments in Wistar rats, the behavioral and hematological effects of the following stress factors were investigated: learning in complex maze and five multiple injections of the physiological saline (0.85%). Increasing of the erythrocyte volume and the contents of hemoglobin per erythrocyte in saline-induced groups and naive rats were observed after the learning. Moreover, the level of corticosterone in plasma of these rats was high. While in heparin-pretreated animals (unfractioned heparin, 64 and 640 IU/kg once per day, i.m., 5 days) these markers of stress are not revealed. The speed and efficiency of learning, behavior organization were significantly better in heparin pretreated rats than in naive and saline-induced groups. In heparin treated rats, a few types of unconditioned responses may be observed suggesting an anxiety or fear. We suppose that, after injections of heparin, complicated biochemical modifications of the rat organism that cause harmonization of inhibiting and excitatory processes of central nervous system, take place.
Kondashevskaia
M V
MV
Mkhitarov
V A
VA
D000818:Animals; D003345:Corticosterone / Q000097:blood; D004911:Erythrocyte Volume; D006454:Hemoglobins / Q000032:analysis; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning; D010146:Pain / Q000150:complications; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood* / Q000209:etiology / Q000523:psychology
D006454:Hemoglobins; D006493:Heparin; D003345:Corticosterone