title: Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin.
abstract: Hepatoprotective effect of the leaves and stems of Ampelopsis grossedentata together with its main constituent, ampelopsin, were examined on D-galactosamine induced liver injury in rats. The diet containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly suppressed the increase of LDH, ALT, AST, alpha-tocopherol levels and GSG/GSSH caused by GalN treatment. These results suggested that ampelopsin from Tocha acted to prevent the oxidative stress in vivo that may have been due to active oxygen species formed by a macrophage by the action of GalN.
authors.affiliation: Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089-8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729-3102, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Murakami
authors.forename: Masazumi
authors.initials: M
authors.lastname: Miyakoshi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Araho
authors.forename: Kenji
authors.initials: K
authors.lastname: Mizutani
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kambara
authors.forename: Takao
authors.initials: T
authors.lastname: Ikeda
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Chou
authors.forename: Mihoko
authors.initials: M
authors.lastname: Inukai
authors.forename: Asako
authors.initials: A
authors.lastname: Takenaka
authors.forename: Kiharu
authors.initials: K
authors.lastname: Igarashi
mesh_terms: D032421:Ampelopsis; D000818:Animals; D004195:Disease Models, Animal; D005688:Galactosamine / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D005688:Galactosamine