title: Pardon me--no access without ubiquitin.
abstract: Spatial separation of ubiquitin conjugation pathways contributes to target-specific ubiquitination. Recently, Plafker et al. reported that importin 11-dependent nuclear import of the ubiquitin-conjugating enzyme UbcM2 occurs only if the latter is charged with ubiquitin. This interesting finding describes a link between nuclear transport pathways and ubiquitin and reveals a novel mechanism for localizing components of the ubiquitin system within the cell.
authors.affiliation: Max-Delbrück Center for Molecular Medicine, Robert-Rossle Str. 10, D-13092 Berlin, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Sommer
authors.forename: Ernst
authors.initials: E
authors.lastname: Jarosch
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000818:Animals; D028884:Karyopherins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D025801:Ubiquitin / Q000502:physiology*; D044763:Ubiquitin-Conjugating Enzymes / Q000378:metabolism
chemical_list: D028884:Karyopherins; D025801:Ubiquitin; D044763:Ubiquitin-Conjugating Enzymes