title: Cerebroside analogues from marine-derived fungus Aspergillus flavipes.
abstract: From the mycelium of the marine-derived fungus Aspergillus flavipes, isolated from the sea anemone Anthopleura xanthogrammica, two new cerebroside analogues, namely flavicerebrosides A (1): [(2S,2'R,3R,4E,8E)-N-2'-hydroxyoctadecanoyl-1-O-beta--galactopyranosyl-9-methyl-4,8-sphingadienine], and B (2): [(2S,2'R,3R,3'E,4E,8E)-N-2'-hydroxy-3'-octadecenoyl-1-O-beta--galactopyranosyl-9-methyl-4,8-sphingadienine], together with two known glycosphingolipids cerebrosides D (3) and C (4), were isolated. Their structures were identified by means of extensive spectroscopic analysis (IR, UV, 2D NMR, MS, CD) and chemical degradation. All four compounds showed cytotoxic activity against the KB cell line.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Jiang
authors.forename: Tian
authors.initials: T
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Hong-Zheng
authors.initials: HZ
authors.lastname: Fu
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
authors.forename: Wen-Han
authors.initials: WH
authors.lastname: Lin
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D002554:Cerebrosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D025282:Mycelium / Q000737:chemistry; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D002554:Cerebrosides; C116025:cerebroside C; C438630:cerebroside D; C498912:flavicerebroside A; C498914:flavicerebroside B; D013110:Sphingosine