title: The effects of coffee consumption on lipid peroxidation and plasma total homocysteine concentrations: a clinical trial.
abstract: Despite extensive research, the cardiovascular effects of coffee consumption in humans remain controversial. Our aim was to investigate the excretion of coffee phenols and the effects of filtered coffee consumption on oxidative stress and plasma homocysteine (tHcy) concentration in humans. The study consisted of a multiple-dose clinical supplementation trial and a single-dose study. In the long-term trial, 43 healthy nonsmoking men optionally consumed daily either no coffee, 3 cups (450 mL), or 6 cups (900 mL) of filtered coffee for 3 weeks, while in the short-term study 35 subjects consumed a single dose of 0, 1 (150 mL), or 2 cups (300 mL) of coffee. Long-term consumption of coffee increased the urinary excretion of caffeic and ferulic acid. The change in the total excretion of phenolic acids in 3 and 6 cups groups represented 3.8 and 2.5% of the amount ingested daily. Plasma tHcy concentrations increased nonsignificantly, but the consumption of coffee had neither short-nor long-term effects on lipid peroxidation or the activity of measured antioxidant enzymes. In conclusion, the consumption of filtered coffee does not have any detectable effects on lipid peroxidation in healthy nonsmoking men. The effect of coffee consumption on tHcy concentrations needs further investigation.
authors.affiliation: Research Institute of Public Health, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland. jaakko.mursu@uku.fi
authors.forename: Jaakko
authors.initials: J
authors.lastname: Mursu
authors.forename: Sari
authors.initials: S
authors.lastname: Voutilainen
authors.forename: Tarja
authors.initials: T
authors.lastname: Nurmi
authors.forename: Georg
authors.initials: G
authors.lastname: Alfthan
authors.forename: Jyrki K
authors.initials: JK
authors.lastname: Virtanen
authors.forename: Tiina H
authors.initials: TH
authors.lastname: Rissanen
authors.forename: Pertti
authors.initials: P
authors.lastname: Happonen
authors.forename: Kristiina
authors.initials: K
authors.lastname: Nyyssönen
authors.forename: Jari
authors.initials: J
authors.lastname: Kaikkonen
authors.forename: Riitta
authors.initials: R
authors.lastname: Salonen
authors.forename: Jukka T
authors.initials: JT
authors.lastname: Salonen
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D003069:Coffee; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D010636:Phenols / Q000652:urine; D010936:Plant Extracts / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000975:Antioxidants; D003069:Coffee; D008055:Lipids; D010636:Phenols; D010936:Plant Extracts; D006710:Homocysteine