title: Use of high throughput genomic tools for the study of endothelial cell biology.
abstract: The endothelium is an active, dynamic and heterogeneous organ. It lines the vessels in every organ system and regulates diverse and important biological functions. Over the past several years researchers have gained enormous insights into endothelial cell function in physiological processes such as coagulation and vascular reactivity, and pathophysiological disease states such as inflammation and atherosclerosis. Despite our expanding knowledge of endothelial cell biology, the molecular mechanisms underlying these functions remain largely unknown. The newly developed high throughput genomic tools and accompanying analytical methods provide powerful approaches for identifying new endothelial cell genes and characterizing their role in health and disease. Here, we review some of the recent genomics and proteomic advances that are providing new methodologies for endothelial cell and vascular biology research.
authors.affiliation: Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA. tomq1@stanford.edu
authors.forename: Raymond
authors.initials: R
authors.lastname: Tabibiazar
authors.forename: Thomas
authors.initials: T
authors.lastname: Quertermous
mesh_terms: D001161:Arteriosclerosis; D019295:Computational Biology; D015180:Electrophoresis, Gel, Two-Dimensional; D004729:Endothelium, Lymphatic / Q000473:pathology* / Q000502:physiology; D004730:Endothelium, Vascular / Q000473:pathology; D005786:Gene Expression Regulation; D005821:Genetic Techniques; D016678:Genome; D015894:Genome, Human; D006801:Humans; D007249:Inflammation; D007834:Lasers; D020411:Oligonucleotide Array Sequence Analysis; D040901:Proteomics / Q000379:methods; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger