title: [Study of antisense oligodeoxynucleotide in reversing multidrug resistance and inducing apoptosis of tumor cells].
abstract: OBJECTIVE
  T o explore an approach to the reversal of multidrug resistance(MDR) of tumor cells.
  
  
  METHODS
  Antisense oligodeoxynucleotide (mdr-1-AS PS-ODN) was used.
  
  
  RESULTS
  A large amount of DNA fragments was found in mdr-1-AS PS-ODN treated K562/ADM cells and almost all the mdr-1+ K562/ADM cells underwent apoptosis.
  
  
  CONCLUSIONS
  mdr-1-AS PS-ODN could inhibit specifically mdr-1 gene expression, effectively reverse MDR of the tumor cells and promote ADM induced apoptosis of mdr-1+ K562/ADM.
authors.affiliation: The Third Clinical College, Norman Bethune University of Medical Sciences, Changchun 130021.
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Lin
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
authors.forename: X
authors.initials: X
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D053938:DNA Fragmentation; D016373:DNA, Antisense / Q000235:genetics*; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D016373:DNA, Antisense