title: [Genetic polymorphisms of five STR loci on chromosome 21 in Chinese Han population].
abstract: To elucidate the genetic polymorphisms of five STR loci on chromosome 21 in Chinese Han population and construct a preliminary database, EDTA-blood specimens were collected from unrelated individuals in Beijing. The DNAs were extracted with Chelex method and were amplified by PCR. The PCR products were analyzed by the PAG electrophoresis or by the approach of the automated fluorescent detection. The five STR loci consist of simple repeat motif and its distributions of genotypes are agreement with Hardy-Weinberg equation. Its polymorphism information content is all over 0.50. The obtained data can not only be used as evidences for genetic diagnosis of Down Syndrome, but also for calculating the probabilities in the paternity test and individual identification.
authors.affiliation: The Laboratory of Electron Microscopy of Fujian Medical University, Fuzhou 350 004, China. czb86233@163.com
authors.forename: Zhen-Bin
authors.initials: ZB
authors.lastname: Chen
authors.forename: Jin-Ling
authors.initials: JL
authors.lastname: Zhu
authors.forename: Mei
authors.initials: M
authors.lastname: Yan
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Tan
authors.forename: Bai
authors.initials: B
authors.lastname: Xiao
authors.forename: Jing-Zhong
authors.initials: JZ
authors.lastname: Liu
mesh_terms: D000483:Alleles; D044466:Asian People; D002681:China / Q000208:ethnology; D002891:Chromosomes, Human, Pair 21; D018076:DNA, Complementary / Q000235:genetics; D004314:Down Syndrome / Q000235:genetics; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D010334:Paternity; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences
chemical_list: D018076:DNA, Complementary; D005819:Genetic Markers