[The new advance of coupled transcription and translation: translation within the nuclei in eukaryotes].
It is well known that the processes of transcription and translation are coupled in prokaryotes. However, in eukaryotes, shortly after the transcription of the primary transcript begins, modifications and processing occur. After the mature mRNA moleculars are transported from the nuclei to the cytoplasm, the translations begin. It shows that the processes of transcription and translation are not coupled in eukaryotes. But now Iborra et al localized translation sites with [3H] lysine or lysyl-tRNA tagged with biotin or BODIPY in mammalian cells and found that there exited coupled transcription and translation within the nuclei. They estimated that the nuclear translation accounted for about 10% to 15% of protein synthesis in the cell.
Gan
Qiang
Q
Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China.
Jin
Li-Ji
LJ
An
Li-Jia
LJ