Exercise and insulin-mediated capillary recruitment in muscle.
Blood flow to contracting muscles is increased rapidly and is redistributed within the muscle. Recent research has highlighted that insulin causes similar changes, but these are absent in insulin resistance, resulting in impaired insulin-mediated muscle glucose uptake. Understanding the mechanisms and interactions between contraction- and insulin-mediated alterations in blood flow within muscle may reveal new approaches to overcome insulin resistance.
Rattigan
Stephen
S
Department of Biochemistry, Medical School, University of Tasmania, Private Bag 58, Hobart, Tasmania, 7001, Australia. S.Rattigan@utas.edu.au
Wheatley
Catherine
C
Richards
Stephen M
SM
Barrett
Eugene J
EJ
Clark
Michael G
MG
D000818:Animals; D002196:Capillaries / Q000254:growth & development*; D015444:Exercise; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007333:Insulin Resistance; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000000981:diagnostic imaging; D009765:Obesity; D051381:Rats; D011924:Rats, Zucker; D014463:Ultrasonography; D014970:Xanthines / Q000378:metabolism
D007328:Insulin; D014970:Xanthines; C053085:1-methylxanthine