Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH.
The recent determination that Angeli's salt may have clinical application as a nitrogen oxide donor for treatment of cardiovascular diseases such as heart failure has led to renewed interest in the mechanism and products of thermal decomposition of Angeli's salt under physiological conditions. In this report, several mechanisms are evaluated experimentally and by quantum mechanical calculations to determine whether HNO is in fact released from Angeli's salt in neutral, aerobic solution. The mechanism of product autoxidation is also considered.
Miranda
Katrina M
KM
Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA. kmiranda@email.arizona.edu
Dutton
Andrew S
AS
Ridnour
Lisa A
LA
Foreman
Christian A
CA
Ford
Eleonora
E
Paolocci
Nazareno
N
Katori
Tatsuo
T
Tocchetti
Carlo G
CG
Mancardi
Daniele
D
Thomas
Douglas D
DD
Espey
Michael G
MG
Houk
K N
KN
Fukuto
Jon M
JM
Wink
David A
DA
D006863:Hydrogen-Ion Concentration; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000378:metabolism; D009573:Nitrites / Q000737:chemistry* / Q000378:metabolism; D016877:Oxidants / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D011789:Quantum Theory; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013816:Thermodynamics
D020030:Nitric Oxide Donors; D009573:Nitrites; D016877:Oxidants; D012996:Solutions; C021229:oxyhyponitrite; D010100:Oxygen