Acute pancreatitis and diabetic ketoacidosis in non-diabetic person while on treatment with sodium valproate, chlorpromazine and haloperidol.
A nondiabetic young male patient in hypomanic phase of bipolar disorder on maintenance treatment with sodium valproate, developed transient episode of acute pancreatitis and diabetic ketoacidosis after addition of chlorpromazine and halopridol. It subsided completely within six weeks and his blood sugar was normal without any antidiabetic therapy. Simultaneous occurrence of acute pancreatitis and diabetic ketoacidosis is reported as a very rare complication of combination of antipsychotic drugs sodium valproate, chlorpromazine and haloperidol. Blood sugar should be periodically monitored in patients on sodium valproate and antipsychotic medication.
Laghate
V D
VD
Dr. Babasaheb Ambedkar Memorial Hospital, Central Railway, Byculla, Mumbai 400 027.
Gupta
S B
SB
D000208:Acute Disease; D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy; D002746:Chlorpromazine / Q000009:adverse effects*; D016883:Diabetic Ketoacidosis / Q000139:chemically induced* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis*; D014635:Valproic Acid / Q000009:adverse effects*
D018692:Antimanic Agents; D014635:Valproic Acid; D006220:Haloperidol; D002746:Chlorpromazine