title: Renal transplantation from cadaveric donor after myocardial revascularization: still a matter of concern?
abstract: Renal transplantation in patients who have undergone coronary revascularization remains a matter of concern, few experiences have been reported in literature. From January 1997 to March 2003, 23 previously revascularized patients underwent renal transplants from cadaveric donors. We analyzed patient survival and cardiac events in this group of patients (group A) versus a similar population of 38 revascularized patients who were still on dialysis (group B) on the active waiting list (awl). After a similar follow-up (29.30 +/- 21.34 months versus 32.98 +/- 31.33 months; P = .56), survival was 100% for renal transplant patients and 94.74% for dialysis patients, two of whom (5.26%) died from acute myocardial infarction and four (10.52%) were excluded from the waiting list because of cardiac problems. The event-person ratio was 0.51 for group A patients (75% of events clustered within the first 6 months) and 0.71 for group B. The need for therapy with nitrates decreased from 11/23 (47.8%) to 6/23 (26%) after transplant. The ejection fraction remained stable (53.82% +/- 10.4% vs pre-Tx value of 54.8% +/- 9.4%). Renal survival was 100% (sCr = 1.4 +/- 0.4 mg/dL). Although no statistical significance has emerged, there was a general trend in favor of transplanted patients. On the basis of this experience we believe that coronary revascularization per se should no longer be a matter of concern for renal transplantation, which could be superior to dialysis for this type of patient.
authors.affiliation: Department of Internal Medicine, Renal Transplant Unit, San Giovanni Battista Hospital, University of Torino, Torino, Italy.
authors.forename: G P
authors.initials: GP
authors.lastname: Segoloni
authors.forename: M
authors.initials: M
authors.lastname: Quaglia
authors.forename: C
authors.initials: C
authors.lastname: Giacosa
authors.forename: M
authors.initials: M
authors.lastname: Ferro
authors.forename: G
authors.initials: G
authors.lastname: Martina
authors.forename: G B
authors.initials: GB
authors.lastname: Piccoli
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D002102:Cadaver; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D012189:Retrospective Studies; D015607:Stents; D016019:Survival Analysis; D014019:Tissue Donors; D016896:Treatment Outcome