Synthesis of a carboxyl linker containing Pk trisaccharide.
An efficient synthesis of a Pk trisaccharide with a functionalized side arm at the reducing end for conjugation to other molecules is presented. Construction of the Pk trisaccharide with a high alpha-selectivity was achieved in high yield by coupling a reactive galactosyl phosphite donor with a lactosyl acceptor.
Hsieh
Shu-Yi
SY
Institute of Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan.
Jan
Mi-Dan
MD
Patkar
Laxmikant N
LN
Chen
Chien-Tien
CT
Lin
Chun-Cheng
CC
D002240:Carbohydrate Sequence; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D014312:Trisaccharides / Q000138:chemical synthesis* / Q000737:chemistry*
D014312:Trisaccharides