CXC chemokines: angiogenesis, immunoangiostasis, and metastases in lung cancer.
CXC chemokines have been found to be important in the regulation of angiogenesis and tumor-related immunity, and in promoting organ-specific metastases. This review highlights the importance of CXC chemokine ligands and receptors in mediating non-small cell lung cancer tumor-associated angiogenesis, "immunoangiostasis," and organ-specific metastases. These findings may ultimately lead to clinical strategies to target CXC chemokines in non-small cell lung cancer.
Strieter
Robert M
RM
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, 900 Veteran Avenue, 14-154 Warren Hall, Los Angeles, CA 90024-1922, USA. rstrieter@mednet.ucla.edu
Belperio
John A
JA
Burdick
Marie D
MD
Sharma
Sherven
S
Dubinett
Steven M
SM
Keane
Michael P
MP
D020816:Amino Acid Motifs; D000818:Animals; D018925:Chemokines / Q000378:metabolism; D019743:Chemokines, CXC / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology*; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology; D009389:Neovascularization, Pathologic; D012333:RNA, Messenger / Q000378:metabolism; D023063:Receptors, Interleukin-8B / Q000378:metabolism
D018925:Chemokines; D019743:Chemokines, CXC; D012333:RNA, Messenger; D023063:Receptors, Interleukin-8B