[Effect of oxygen therapy for injury of intestinal mucosal barrier of rabbits in high altitude hemorrhagic shock].
OBJECTIVE
To investigate the protective effects of oxygen therapy on gut barrier function of rabbits after hemorrhagic shock at high altitude.


METHODS
Fifteen rabbits were exposed to a simulated 4000 m high altitude in a hypobaric chamber, and they were randomly divided into two groups of treatment and control. Then hemorrhagic shock was induced through bleeding to mean artery pressure 40 mmHg (1 mmHg=0.133 kPa). After 1 hour, the rabbits were resuscitated with infusion of total volume of shed blood and balanced saline equivalent to 1.5 times of the shed blood. In addition, the animals of the treatment group were given oxygen therapy.


RESULTS
After 4 hours treatment, the mean arterial pressure of the treatment group was increased significantly in comparison with the control group, and the concentrations of plasma lactate in the former were significantly decreased after treatment for 4 hours and 8 hours. The plasma lipopolysaccharide levels in the treatment group were significantly lower than those in the control after treatment, and the histologic evidence of damage to the intestinal mucosa of the rabbits in the treatment group was less marked than that in the control group (P<0.05 or P<0.01).


CONCLUSIONS
Hemorrhagic shock at high altitude may cause disruption of the intestinal mucosa barrier and oxygen therapy could afford protection to the intestinal mucosa barrier in such circumstance.
Dong
Yan
Y
Department of Nursing, The Third Military Medical University, Chongqing 400038, China.
Zheng
Jiang
J
Wang
Xian-yuan
XY
Zhou
Juan
J
D000532:Altitude Sickness / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004195:Disease Models, Animal; D007413:Intestinal Mucosa / Q000473:pathology*; D010102:Oxygen Inhalation Therapy; D011817:Rabbits; D011897:Random Allocation; D012771:Shock, Hemorrhagic / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy