title: Novel antioxidants isolated from plants of the genera Ferula, Inula, Prangos and Rheum collected in Uzbekistan.
abstract: We examined the effects of 48 compounds isolated from Ferula pallida, F. penninervis, Inula macrophylla, Prangos pabularia, P. tschimganica and Rheum maximowiczii collected in Uzbekistan on ADP/Fe2+-induced lipid peroxidation of egg yolk phosphatidylcholine liposomes. Of those compounds, 23 inhibited ADP/Fe2+-induced lipid peroxidation and nine showed especially strong inhibition of lipid peroxidation. Most compounds that inhibited peroxidation scavenged the 1,1'-diphenyl-2-picrylhydrazyl (DPPH) radical, indicating that the inhibition was due to radical scavenging. However, some compounds did not scavenge DPPH but inhibited lipid peroxidation significantly, suggesting that their inhibitory effect was not due to radical scavenging but to some other mechanism, such as prevention of Fe2+ function. Thus, we found various new antioxidants, some of which had a unique mechanism of action, in Ferula, Inula, Prangos and Rheum plants collected in Uzbekistan as seeds used in medicine.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi-1, 770-8505 Tokushima, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kogure
authors.forename: I
authors.initials: I
authors.lastname: Yamauchi
authors.forename: A
authors.initials: A
authors.lastname: Tokumura
authors.forename: K
authors.initials: K
authors.lastname: Kondou
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Takaishi
authors.forename: K
authors.initials: K
authors.lastname: Fukuzawa
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D005309:Ferula / Q000737:chemistry*; D038143:Inula / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D008081:Liposomes / Q000378:metabolism; D015394:Molecular Structure; D012250:Rheum / Q000737:chemistry*; D014610:Uzbekistan
chemical_list: D000975:Antioxidants; D008081:Liposomes