title: Postoperative Level 1 anticoagulation therapy and spinal surgery: practical guidelines for management.
abstract: OBJECTIVE
  The authors conducted a review of the literature to establish reasonable practical guidelines for the management of complications in patients who have undergone recent spinal surgery and who require Level 1 anticoagulation therapy.
  
  
  METHODS
  A MEDLINE (PubMed) literature search was performed using the key words "postoperative anticoagulation," "spinal surgery," and "postoperative epidural hematoma," for articles published between 1990 and 2004. The search yielded 148 articles, which were then further screened for relevance and classified according to level-of-evidence guidelines established by the American Association of Neurological Surgeons/Congress of Neurological Surgeons joint committee for spinal cord injury. A total of 12 relevant articles were reviewed. There were no relevant articles meeting Class 1 standards of evidence, two met Class 2 evidence standards (one was a nonrandomized cohort study, the other was case-controlled), and the remaining 10 articles contained Class 3 evidence.
  
  
  CONCLUSIONS
  There are insufficient data to establish evidence-based guidelines for the use of Level 1 heparin or an equivalent anticoagulation protocol in patients who have recently undergone spinal surgery. Nevertheless, a search of the limited peer-reviewed literature on the subject indicates that there is an anecdotally high risk of complications in patients who have undergone spinal surgery and in whom a Level 1 or equivalent heparin protocol is administered. It therefore seems most prudent to arrange for placement of a vena cava filter in patients who have undergone spinal surgery and in whom a pulmonary embolus is found postoperatively. In patients who undergo spinal surgery and who require heparinization therapy for myocardial ischemia or infarction, the use of frequent neurological examinations in conjunction with anticoagulation therapy seems to be the only reasonable option.
authors.affiliation: Department of Neurosurgery, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157-1029, USA. bbarnes@wfubmc.edu
authors.forename: Bryan
authors.initials: B
authors.lastname: Barnes
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Alexander
authors.forename: Charles L
authors.initials: CL
authors.lastname: Branch
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D019468:Disease Management; D006801:Humans; D011182:Postoperative Care / Q000379:methods* / Q000592:standards*; D017410:Practice Guidelines as Topic / Q000592:standards*; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000601:surgery*
chemical_list: D000925:Anticoagulants