[Effects of ginkgolide on cerebral blood flow in dogs].
OBJECTIVE
To observe the effects of ginkgolide (GL) on the cerebral blood flow in dogs.


METHODS
Dogs anesthetized with sodium pentobarbital were randomly divided into 5 groups, with 4 dogs in each group. Ginkgolide of 4.86, 14.6 and 43.7 mg/kg and Xingling Granule of 0.22 g/kg were administered by gavage to the dogs in each of 4 groups. The dogs in the other group were administered with edible oil (1 ml/kg) as control group. The cerebral blood flow, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and electro-cardiogram of the dogs were measured at different times after the administration.


RESULTS
Ginkgolide of 4.86, 14.6 and 43.7 mg/kg had no obvious effects on the blood pressure and the heart rate. Ginkgolide of 14.6 and 43.7 mg/kg increased the cerebral blood flow 90 minutes after administration, and ginkgolide of 43.7 mg/kg obviously decreased the cerebral vascular resistance 150 minutes after administration.


CONCLUSIONS
Ginkgolide can increase the cerebral blood flow and decrease the cerebral vascular resistance, and it has no obvious effects on blood pressure and heart rate in dogs.
Xu
Jiang-Ping
JP
Department of Pharmacology, First Military Medical University, Guangzhou, Guangdong Province 510515, China. jpx @fimmu.com
Li
Lin
L
Sun
Li-Sha
LS
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D005260:Female; D046934:Ginkgolides / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D014655:Vascular Resistance / Q000187:drug effects
D046934:Ginkgolides