title: Influence of smoking on maternal and neonatal serum malondialdehyde, superoxide dismutase, and glutathione peroxidase levels.
abstract: This cohort study investigated postnatal serum malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels in 14 active-smoking, 14 passive-smoking, and 15 non-smoking mothers and their newborns on day 7 post-partum. No significant differences were noted among the study groups with respect to MDA (p = 0.63) or SOD levels (p = 0.98) in either the mothers or their infants. However, there were significant differences among the study groups with respect to serum GPx activities in both the mothers (p = 0.028) and the infants (p = 0.039). When GPx activities were analyzed separately in both mothers and infants, a significant difference was noted only between the infants of smoking mothers and the infants of non-smoking mothers (p = 0.015). In conclusion, there was a significant increase in GPx activities of smoking mothers and their infants, suggesting that they may have been exposed to more oxidant stress.
authors.affiliation: Department of Pediatrics, School of Medicine, Zonguldak Karaelmas University, 67600 Kozlu/Zonguldak, Turkey. bahriermis@yahoo.com
authors.forename: Bahri
authors.initials: B
authors.lastname: Ermis
authors.forename: Rahmi
authors.initials: R
authors.lastname: Ors
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Yildirim
authors.forename: Ayhan
authors.initials: A
authors.lastname: Tastekin
authors.forename: Fatih
authors.initials: F
authors.lastname: Kardas
authors.forename: Fatih
authors.initials: F
authors.lastname: Akcay
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008431:Maternal-Fetal Exchange; D018384:Oxidative Stress / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012907:Smoking / Q000009:adverse effects / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
chemical_list: D014028:Tobacco Smoke Pollution; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase