Design of oligolactone-based scaffolds for bone tissue engineering.
Novel difunctional oligolactone macromers have been synthesized by ring-opening oligomerization of various lactones (L-lactide, glycolide, p-dioxanone) in the presence of suitable diols (propane-1,2-diol, dianhydro-D-glucitol) and subsequent endcapping of the formed oligolactones with methacrylate moieties. Based on these macromers, two fabrication procedures were developed to fabricate highly porous scaffolds and the material properties including in vitro biodegradation behaviour of the resulting polymeric scaffolds were investigated. Preliminary in vitro studies on the cytocompatibility of the fabricated scaffolds and on osteoblast cultivation on the optimized polymeric materials demonstrated that the oligolactide based polymer networks possess an excellent biocompatibility and that they are promising candidates as scaffolds in bone tissue engineering.
Vogt
S
S
INNOVENT Technologieentwicklung e.V., Pruessingstrasse 27B, D-07745 Jena, Germany.
Berger
S
S
Wilke
I
I
Larcher
Y
Y
Weisser
J
J
Schnabelrauch
M
M
D016475:3T3 Cells; D020341:Absorbable Implants; D000818:Animals; D001705:Bioprosthesis; D018786:Bone Substitutes; D002448:Cell Adhesion / Q000502:physiology; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D007783:Lactones / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D008970:Molecular Weight; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology*; D016062:Porosity; D011474:Prosthesis Design; D023822:Tissue Engineering / Q000379:methods*
D018786:Bone Substitutes; D007783:Lactones