title: A model of the dynamic relationship between blood flow and volume changes during brain activation.
abstract: The temporal relationship between changes in cerebral blood flow (CBF) and cerebral blood volume (CBV) is important in the biophysical modeling and interpretation of the hemodynamic response to activation, particularly in the context of magnetic resonance imaging and the blood oxygen level-dependent signal. measured the steady state relationship between changes in CBV and CBF after hypercapnic challenge. The relationship CBV is proportional to CBFphi has been used extensively in the literature. Two similar models, the Balloon and the Windkessel , have been proposed to describe the temporal dynamics of changes in CBV with respect to changes in CBF. In this study, a dynamic model extending the Windkessel model by incorporating delayed compliance is presented. The extended model is better able to capture the dynamics of CBV changes after changes in CBF, particularly in the return-to-baseline stages of the response.
authors.affiliation: Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, UK.
authors.forename: Yazhuo
authors.initials: Y
authors.lastname: Kong
authors.forename: Ying
authors.initials: Y
authors.lastname: Zheng
authors.forename: David
authors.initials: D
authors.lastname: Johnston
authors.forename: John
authors.initials: J
authors.lastname: Martindale
authors.forename: Myles
authors.initials: M
authors.lastname: Jones
authors.forename: Steve
authors.initials: S
authors.lastname: Billings
authors.forename: John
authors.initials: J
authors.lastname: Mayhew
mesh_terms: D000818:Animals; D001810:Blood Volume / Q000502:physiology; D001921:Brain / Q000098:blood supply* / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D008954:Models, Biological; D051381:Rats; D012680:Sensitivity and Specificity; D013997:Time Factors