title: The periarterial space in the lung: its important role in lung edema, transplantation, and microbial or allergic inflammation.
abstract: In mammal lungs different compartments for leukocytes can be identified during health and disease, e.g. lung interstitium, bronchoalveolar space, the epithelium and lamina propria of the air-conducting part. A so far neglected compartment is the space around the branches of the pulmonary arteries, characterized by a unique architecture of capillaries running in parallel to the pulmonary artery. This compartment - the periarterial space - is described and its physiological and pathophysiological role reviewed. The periarterial space is infiltrated by different leukocyte subsets during edema formation in the early stages of a lung transplant rejection and, in particular, during inflammatory and allergic reactions. The periarterial compartment seems to be of major relevance in all these situations.
authors.affiliation: Department of Functional and Applied Anatomy, Medical School of Hannover, Hannover, Germany. Pabst.Reinhard@mh-hannover.de
authors.forename: R
authors.initials: R
authors.lastname: Pabst
mesh_terms: D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology*; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology*; D007962:Leukocytes / Q000276:immunology; D008168:Lung / Q000098:blood supply* / Q000382:microbiology* / Q000503:physiopathology; D016040:Lung Transplantation / Q000276:immunology*; D011651:Pulmonary Artery / Q000276:immunology; D011654:Pulmonary Edema / Q000209:etiology / Q000503:physiopathology*