Inflammatory diseases: is ubiquitinated NEMO at the hub?
Many patients with Crohn's disease carry mutations in NOD2, a molecule that can both activate and attenuate the pro-inflammatory effects of NF-kappa B. Recent studies implicate NOD2-induced ubiquitination of the NF-kappa B regulator NEMO as a potential means of manipulating the NF-kappa B signal.
Burns
Kimberly A
KA
Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland. KimberlyA.BurnsdiMarco@ib.unil.ch
Martinon
Fabio
F
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D003424:Crohn Disease / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D051550:I-kappa B Kinase; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D016328:NF-kappa B / Q000378:metabolism*; D053473:Nod2 Signaling Adaptor Protein; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism
D002352:Carrier Proteins; C491731:IKBKG protein, human; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D025801:Ubiquitin; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D051550:I-kappa B Kinase