title: Systemic lupus erythematosus with simultaneous onset of Kikuchi-Fujimoto's disease complicated with antiphospholipid antibody syndrome: a case report and review of the literature.
abstract: Histiocytic necrotizing lymphadenitis, called Kikuchi-Fujimoto's disease (KFD), is an idiopathic, self-limited condition rarely associated with systemic lupus erythematosus (SLE). The cause of concomitant KFD and SLE is still unknown. We describe a 19-year-old man simultaneously diagnosed with both KFD and SLE complicated with deep vein thrombosis (DVT). To the best of our knowledge, this is the first case report of KFD associated with SLE complicated with antiphospholipid antibody syndrome (APS). Our patient was successfully treated with intravenous pulse methylprednisolone, anticoagulation with heparin, oral hydroxychloroquine, azathioprine, and low-dose aspirin.
authors.affiliation: Division of Rheumatology-Immunology-Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, 325, Section 2, Cheng-Kung Road, 114 Neihu, Taipei, Taiwan.
authors.forename: Hsiang-Cheng
authors.initials: HC
authors.lastname: Chen
authors.forename: Jenn-Haung
authors.initials: JH
authors.lastname: Lai
authors.forename: Guo-Shu
authors.initials: GS
authors.lastname: Huang
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Gao
authors.forename: Chen-Hung
authors.initials: CH
authors.lastname: Chen
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Kuo
authors.forename: Deh-Ming
authors.initials: DM
authors.lastname: Chang
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006493:Heparin / Q000627:therapeutic use; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007275:Injections, Intravenous; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D018501:Antirheumatic Agents; D006886:Hydroxychloroquine; D006493:Heparin; D001379:Azathioprine; D001241:Aspirin; D008775:Methylprednisolone