Antidiabetic coumarin and cyclitol compounds from Peucedanum japonicum.
The antidiabetic activity-guided fractionation and isolation of the 80% EtOH extracts from Peucedani Radix (Peucedanum japonicum, Umbelliferae) led to the isolation and characterization of a coumarin and a cyclitol as active principles, that is, peucedanol 7-O-beta-D-glucopyranoside (1) and myo-inositol (2). Their structures were identified by spectroscopic methods. Compound 1 showed 39% inhibition of postprandial hyperglycemia at 5.8 mg/kg dose, and compound 2 also significantly inhibited postprandial hyperglycemia by 34% (P<0.05).
Lee
Sung Ok
SO
Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon, Gyeonggi-Do 440-746, Korea.
Choi
Sang Zin
SZ
Lee
Jong Hwa
JH
Chung
Sung Hyun
SH
Park
Sang Hyun
SH
Kang
Hee Chol
HC
Yang
Eun Young
EY
Cho
Hi Jae
HJ
Lee
Kang Ro
KR
D000818:Animals; D019661:Apiaceae; D001786:Blood Glucose / Q000187:drug effects / Q000502:physiology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots
D001786:Blood Glucose; D003374:Coumarins; D007004:Hypoglycemic Agents; D010936:Plant Extracts; C030123:coumarin