title: Clonal diversity of metallo-beta-lactamase-possessing Pseudomonas aeruginosa in geographically diverse regions of Japan.
abstract: The aim of this study was to determine the distribution of metallo-beta-lactamase-producing Pseudomonas aeruginosa in Japan and to investigate the molecular characteristics of resistance gene cassettes including the gene encoding this enzyme. A total of 594 nonduplicate strains of P. aeruginosa isolated from 60 hospitals throughout Japan in 2002 were evaluated. This study indicated that although the prevalence of imipenem-resistant P. aeruginosa has not increased compared to that found in previous studies, clonal distribution of the same strain across Japan is evident.
authors.affiliation: Department of Microbiology, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo 1438540, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Kimura
authors.forename: Jimena
authors.initials: J
authors.lastname: Alba
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Shiroto
authors.forename: Reiko
authors.initials: R
authors.lastname: Sano
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Niki
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Maesaki
authors.forename: Koji
authors.initials: K
authors.lastname: Akizawa
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kaku
authors.forename: Yuji
authors.initials: Y
authors.lastname: Watanuki
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ishii
authors.forename: Keizo
authors.initials: K
authors.lastname: Yamaguchi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003227:Conjugation, Genetic; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D032023:Integrons / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases