Absence of cholinergic deficits in "pure" vascular dementia.
Choline acetyltransferase in temporal cortex was evaluated as a marker of cholinergic function in autopsied dementia cases (9 vascular dementia [VaD] cases, 12 "mixed" VaD and Alzheimer disease [AD] cases, 10 AD cases, 12 control subjects). Patients with AD (t = 2.5, p = 0.02) and "mixed" VaD and AD (t = 3.8, p = 0.001) had greater cholinergic deficits than age-matched control subjects and patients with "pure" VaD. The absence of cholinergic deficits in "pure" VaD may be relevant to the pharmacologic treatment of these patients.
Perry
E
E
Newcastle General Hospital, MRC Bldg., Westgate Rd., Newcastle upon Tyne, NE4 6BE, UK. e.k.perry@ncl.ac.uk
Ziabreva
I
I
Perry
R
R
Aarsland
D
D
Ballard
C
C
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000172:deficiency* / Q000502:physiology; D015140:Dementia, Vascular / Q000150:complications / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D013702:Temporal Lobe / Q000201:enzymology
D002795:Choline O-Acetyltransferase