title: Comparison of the effects of a distal embolic protection device and an aspiration catheter during percutaneous coronary intervention in patients with acute myocardial infarction.
abstract: BACKGROUND
  The beneficial effect of percutaneous coronary intervention (PCI) using stents for acute myocardial infarction (AMI) has already been demonstrated, but there is the problem that mechanical microvascular occlusion can occur because of thrombus/atheroma embolization when the PCI was performed. The aim of the present study was to retrospectively test and compare the effects of an aspiration catheter or distal embolic protection with a distal occlusion balloon catheter to prevent peripheral vascular embolization.
  
  
  RESULTS
  The subjects consisted of 135 patients who underwent PCI with stenting within 12 h of the onset of chest pain caused by their first AMI. They were divided into 2 groups; the aspiration group, consisted of 81 consecutively seen patients who underwent aspiration catheter treatment between January 2001 and May 2002, and the distal protection group was the next group of 54 consecutively seen patients treated with a distal protection device between June 2002 and February 2003. The results were as follows. Thrombolysis in Myocardial Infarction (TIMI) score of 3 was obtained significantly more frequently in the distal protection group (94.4%) than in the aspiration group (79.0%). Additionally, the intensity of the cardiac muscle stain (blush score) was evaluated on coronary angiography and the rate of cases showing a blush score of 3, which indicates favorable blood perfusion at the tissue level, in the distal protection group (56.6%) was significantly greater than in the aspiration group (33.3%, p<0.01). The time to peak blood concentration of creatinine kinase was also significantly shorter in the distal protection group.
  
  
  CONCLUSIONS
  The distal embolism protection method is superior to the aspiration method for prevention of embolization after PCI with stenting for AMI, in terms of tissue level reperfusion in myocardial recanalization therapy.
authors.affiliation: Department of Cardiology and Pneumology, Dokkyo University School of Medicine, Tochigi, Japan. taguchi@dokkyomed.ac.jp
authors.forename: Isao
authors.initials: I
authors.lastname: Taguchi
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Kanaya
authors.forename: Toru
authors.initials: T
authors.lastname: Toi
authors.forename: Shichirou
authors.initials: S
authors.lastname: Abe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sugimura
authors.forename: Toshiyasu
authors.initials: T
authors.lastname: Hoshi
authors.forename: Akitsugu
authors.initials: A
authors.lastname: Oida
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Araki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ogawa
authors.forename: Noboru
authors.initials: N
authors.lastname: Kaneko
mesh_terms: D006328:Cardiac Catheterization / Q000379:methods; D003326:Coronary Circulation; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000628:therapy*; D015425:Myocardial Reperfusion; D011859:Radiography; D012189:Retrospective Studies; D015607:Stents; D013396:Suction