title: An adaptive drug infusion system.
abstract: BACKGROUND
  In order to reduce the overall size and power consumption of ambulatory drug infusion systems, and to provide higher delivery accuracy, faster start-up, and more rapid occlusion detection, a non-contacting, low-power thermal time-of-flight technology has been used to provide a pressure-based miniature wearable drug infusion system that automatically compensates in real time for changes in pressure, viscosity, and flow path geometry.
  
  
  METHODS
  Prototypes have been designed, built, and tested on the bench and on animals.
  
  
  RESULTS
  For liquid volumes ranging from 30 nL to 100 microL, the measured accuracy and precision of delivery were better than 1%. Tests on 30-kg swine showed delivery within the study accuracy.
  
  
  CONCLUSIONS
  The performance of the prototypes demonstrates that real-time compensation of flow variables provides significant performance improvements in therapeutic infusion.
authors.affiliation: TheraFuse, Inc., Carlsbad, California 92008, USA.
authors.forename: Meghan
authors.initials: M
authors.lastname: Simmons
authors.forename: David
authors.initials: D
authors.lastname: Gillett
authors.forename: Brian
authors.initials: B
authors.lastname: Catanzaro
authors.forename: Barry
authors.initials: B
authors.lastname: Jacobs
authors.forename: David C
authors.initials: DC
authors.lastname: Klonoff
authors.forename: Burton
authors.initials: B
authors.lastname: Sage
mesh_terms: D004867:Equipment Design; D006801:Humans; D015918:Infusion Pumps, Implantable; D007328:Insulin / Q000008:administration & dosage; D013677:Medical Laboratory Science; D018670:Monitoring, Ambulatory; D015203:Reproducibility of Results
chemical_list: D007328:Insulin