Presence of anti-kinectin and anti-PMS1 antibodies in Japanese aplastic anaemia patients.
While anti-kinectin antibodies are frequently found in aplastic anaemia (AA) patients from the US (39%), we detected antibodies in only three of 30 (10%) of Japanese AA cases. Additionally, population differences in anti-postmeiotic segregation increased 1 (PMS1) responses were seen, with detectable antibody in 10% Japanese and 0% US AA patients. In one of the Japanese AA patients with detectible anti-kinectin antibodies, the autoantibody disappeared coincidentally with the partial resolution of pancytopenia. These results support the hypothesis that the epidemiology of AA is heterogeneous and suggest that anti-kinectin autoantibody titre may serve as a surrogate maker for the disease activity of AA.
Hirano
Naoto
N
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. naoto_hirano@dfci.harvard.edu
Butler
Marcus O
MO
Guinan
Eva C
EC
Nadler
Lee M
LM
Kojima
Seiji
S
D000741:Anemia, Aplastic / Q000276:immunology*; D000755:Anemia, Sickle Cell / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015153:Blotting, Western / Q000379:methods; D002352:Carrier Proteins / Q000276:immunology*; D016022:Case-Control Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007564:Japan; D008565:Membrane Proteins / Q000276:immunology*; D013789:Thalassemia / Q000097:blood
D001323:Autoantibodies; D015415:Biomarkers; D002352:Carrier Proteins; D007074:Immunoglobulin G; C088547:KTN1 protein, human; D008565:Membrane Proteins