[Studies on the genetic diathesis of asthma bronchial].
To study the association of genes polymorphisms in glutathione S-transferase M1 and T1 with asthma bronchial. The distribute frequency of allele(+) and allele(o) between GSTM1 and GSTT1 of 60 patients asthma bronchial and 60 control groups in Tangshan was studied with PCR. The result shown GSTM1 deficiency allele(0/0) frequency of asthma bronchial was 81.2%, which showed significantly higher(chi(2)=32.46, P<0.001; wchi(2)=28.75,P<0.001) than the control groups; GSTT1 was similar to GSTM1. But GSTT1 zero allele(0/0) frequency of asthma bronchial were 71.7%, which were significantly higher (chi(2)=26.72, P<0.001; wchi(2)=35.75, P<0.001) than the control groups(11.7%). Zero allele of GSTM1 and GSTT1 were showed the most features in the asthma bronchial. Associated significantly in the genes polymorphisms of GSTM1 and GSTT1 with asthma bronchial, their genes mutation may be the genetic risk factor of asthma bronchial.
Zhang
Ying-Qi
YQ
The Department of Respiration of workers' Hospital of Tangshan in Hebei, Tangshan 063000, China. annazhangyq@vip.sina.com
Sun
Bai-Yun
BY
Dai
Jian-Jun
JJ
Wu
Shou-Shan
SS
Zhang
An-Ping
AP
Zhao
Chen-Fu
CF
Ning
Shu-Cheng
SC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001249:Asthma / Q000201:enzymology / Q000235:genetics*; D002681:China; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1