title: Curcumin influences hepatic expression patterns of matrix metalloproteinases in liver toxicity.
abstract: Hepatic fibrosis is a result of an imbalance between enhanced matrix synthesis and diminished breakdown of connective tissue proteins, the net result of which is increased deposition of Extra Cellular Matrix. In this concept Matrix Metalloproteinases play an important role because their activity is largely responsible for extra cellular matrix breakdown. In the present study we have tested the influence of curcumin, the active principle of turmeric, on matrix metalloproteinase expression during alcohol and thermally oxidised sunflower oil induced liver toxicity. Male albino Wistar rats were used for the study. The matrix metalloproteinase expressions were found to be increased significantly in alcohol as well as thermally oxidised sunflower oil groups and on treatment with curcumin there was a significant decrease. In alcohol + thermally oxidised sunflower oil group, we found a significant decrease in matrix metalloproteinase activities. Administration of curcumin significantly improved their activities. From the results obtained, we could conclude that curcumin influences the hepatic matrix metalloproteinases and effectively protects liver against alcohol and delta PUFA induced toxicity.
authors.affiliation: Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India.
authors.forename: Rajagopalan
authors.initials: R
authors.lastname: Rukkumani
authors.forename: Kode
authors.initials: K
authors.lastname: Aruna
authors.forename: Penumathsa Suresh
authors.initials: PS
authors.lastname: Varma
authors.forename: Venugopal Padmanabhan
authors.initials: VP
authors.lastname: Menon
mesh_terms: D000818:Animals; D003474:Curcumin / Q000633:toxicity*; D004347:Drug Interactions; D000431:Ethanol; D005231:Fatty Acids, Unsaturated; D008099:Liver / Q000201:enzymology; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000201:enzymology*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D010084:Oxidation-Reduction; D010938:Plant Oils; D051381:Rats; D000074242:Sunflower Oil
chemical_list: D005231:Fatty Acids, Unsaturated; D010938:Plant Oils; D000074242:Sunflower Oil; D000431:Ethanol; D020782:Matrix Metalloproteinases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D003474:Curcumin