title: Pathbase: a new reference resource and database for laboratory mouse pathology.
abstract: Pathbase (http://www.pathbase.net) is a web accessible database of histopathological images of laboratory mice, developed as a resource for the coding and archiving of data derived from the analysis of mutant or genetically engineered mice and their background strains. The metadata for the images, which allows retrieval and interoperability with other databases, is derived from a series of orthogonal ontologies and controlled vocabularies. One of these controlled vocabularies, MPATH, was developed by the Pathbase Consortium as a formal description of the content of mouse histopathological images. The database currently has over 1000 images on-line with 2000 more under curation and presents a paradigm for the development of future databases dedicated to aspects of experimental biology.
authors.affiliation: Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. PS@mole.bio.cam.ac.uk
authors.forename: Paul N
authors.initials: PN
authors.lastname: Schofield
authors.forename: Jonathan B L
authors.initials: JB
authors.lastname: Bard
authors.forename: Jacques
authors.initials: J
authors.lastname: Boniver
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Covelli
authors.forename: Philippe
authors.initials: P
authors.lastname: Delvenne
authors.forename: Michele
authors.initials: M
authors.lastname: Ellender
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Engstrom
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Goessner
authors.forename: Michael
authors.initials: M
authors.lastname: Gruenberger
authors.forename: Heinz
authors.initials: H
authors.lastname: Hoefler
authors.forename: John W
authors.initials: JW
authors.lastname: Hopewell
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Mancuso
authors.forename: Carmel
authors.initials: C
authors.lastname: Mothersill
authors.forename: Leticia
authors.initials: L
authors.lastname: Quintanilla-Martinez
authors.forename: Bjorn
authors.initials: B
authors.lastname: Rozell
authors.forename: Hannu
authors.initials: H
authors.lastname: Sariola
authors.forename: John P
authors.initials: JP
authors.lastname: Sundberg
authors.forename: Andrew
authors.initials: A
authors.lastname: Ward
mesh_terms: D000818:Animals; D019295:Computational Biology; D016208:Databases, Factual; D005838:Genotype; D016247:Information Storage and Retrieval; D020407:Internet; D051379:Mice; D009154:Mutation; D010336:Pathology; D010641:Phenotype; D018875:Vocabulary, Controlled