title: Cut-off value of the ankle-brachial pressure index at which the accuracy of brachial-ankle pulse wave velocity measurement is diminished.
abstract: BACKGROUND
  The present study was conducted to establish the cutoff value of the ankle-brachial pressure index (ABI) at which the accuracy of brachial-ankle pulse wave velocity (baPWV) measurement is diminished.
  
  
  RESULTS
  The baPWV and ABI were measured in 1,361 patients with an atherosclerosis-related disease and 7,889 subjects without any atherosclerotic risk factors, in order to determine the percent difference of the brachial-ankle PWV (%baPWV), the angle of the rise of the anacrotic limb (%angle) and of the amplitude of the entire waveform (%amplitude) in both sides. The %angle and %amplitude were significantly higher in subjects whose %baPWV was >or=19% than in those subjects whose %baPWV was <19% (19% was the mean value+3SD of 7,889 healthy subjects). The %baPWV >or=19% was defined as the abnormal discrepancy of baPWV caused by arterial stenosis in both sides. The receiver operator characteristic curve discriminated the abnormal discrepancy of baPWV by ABI because the area under the curve was 0.86. The highest discriminating sensitivity and specificity were 91% and 75% at ABI =0.95.
  
  
  CONCLUSIONS
  An ABI <0.95 seems to be the marker of diminished baPWV accuracy.
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
authors.forename: Koki
authors.initials: K
authors.lastname: Motobe
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tomiyama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Koji
authors.forename: Minoru
authors.initials: M
authors.lastname: Yambe
authors.forename: Zaydun
authors.initials: Z
authors.lastname: Gulinisa
authors.forename: Tomio
authors.initials: T
authors.lastname: Arai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ichihashi
authors.forename: Tsuneyuki
authors.initials: T
authors.lastname: Nagae
authors.forename: Shin
authors.initials: S
authors.lastname: Ishimaru
authors.forename: Akira
authors.initials: A
authors.lastname: Yamashina
mesh_terms: D000842:Ankle / Q000098:blood supply; D001161:Arteriosclerosis / Q000503:physiopathology; D001794:Blood Pressure; D001916:Brachial Artery / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012189:Retrospective Studies; D012727:Sex Characteristics; D012907:Smoking / Q000453:epidemiology