Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorder.
Genome-wide scans in bipolar disorder and a meta analysis on published data have provided evidence for linkage to chromosome 13q, although the reported peaks from various studies have not converged in a narrow region. Recently, single nucleotide polymorphisms (SNPs) at the G72/G30 locus have been shown to be associated with bipolar disorder suggesting its potential role in increasing disease risk. The proposed linkage region on 13q extends over a wide span, and could provide a clue to the existence of other susceptibility variants. In the present study, SNPs in the LOC93081-KDELC1-BIVM, a region proximal to G72, were interrogated in two bipolar family series. KDELC1 has a predicted filamin domain and BIVM contains an immunoglobulin-like motif. The small pedigree series yielded a nominally significant global P-value due to under-transmission of a rare haplotype but this finding was not supported by results from the larger series and in the case-control study that compared 278 cases and 277 controls.
Ferraren
Dilberto O
DO
Genetic Basis for Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA.
Liu
Chunyu
C
Badner
Judith A
JA
Corona
Winston
W
Rezvani
Azadeh
A
Monje
Virginia D
VD
Gershon
Elliot S
ES
Bonner
Tom I
TI
Detera-Wadleigh
Sevilla D
SD
D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D003285:Contractile Proteins / Q000235:genetics; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004252:DNA Mutational Analysis; D005192:Family Health; D005260:Female; D064448:Filamins; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008840:Microfilament Proteins / Q000235:genetics; D018895:Microsatellite Repeats; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide
D003285:Contractile Proteins; D064448:Filamins; D007136:Immunoglobulins; D008840:Microfilament Proteins; D004247:DNA