[Quality of life in patients with chronic obstructive pulmonary disease before and after the treatment with prednisone].
OBJECTIVE
To evaluate quality of life (QOL) and correlation between QOL and lung ventilation in chronic obstructive pulmonary disease (COPD) patients before and after the treatment with prednisone.


METHODS
75 patients with COPD were enrolled in the open study (mean 57,76 years of age; 32 smokers, reversible obstruction <15%). Before and after the treatment with prednisone (encorton, Polfa Pabianice) in patients with COPD: 1) IC, VC, FEV1, PEF, MEF75, MEF50, MEF25, FEV1%VC (Lung-Test 500 MES), and 2) QOL questionnaire were studied. The treatment with prednisone was as follows: 1) 30 mg/d - 14 days, 2) 20 mg/d - 14 days, 3) 15 mg/d - 7 days, 4) 10 mg/d- 7 days. At the same time formoterol and i theophylline were continued with COPD patient in stable doses as before enrolment.


RESULTS
In patients with COPD after the treatment with prednisone statistical significant increase quality of life (QOL) was obtained. The improvement of QOL questionnaire scores was accompanied by the improvement of the lung function and relationship between them after the treatment with prednisone was statistical significant better then before treatment.


CONCLUSIONS
In patients with COPD after the treatment with prednisone: the significant improvement QOL and lung function were found; the significant higher correlation between QOL and lung function then before treatment was determined.
Bijata-Bronisz
Renata
R
Katedra i Klinika Alergologii i Chorób Wewnetrznych AM w Bydgoszczy. inchal@amb.bydgoszcz.pl
Dziedziczko
Andrzej
A
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001294:Attitude to Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D011239:Prednisolone