An investigation of neuronal integrity in severe paediatric traumatic brain injury.
Magnetic Resonance Spectroscopy (MRS) and its association with neuropsychological functioning was examined in the chronic injury phase of paediatric traumatic brain injury (TBI). Fifteen children, aged 10-16 years, with severe TBIs were compared with 15 controls, matched for age and gender. The TBI group was found to have significantly lower levels of -acetyl aspartate (NAA) and Choline (Cho) in the right frontal lobe and generally displayed reduced performances on neuropsychological tests. A correlation between metabolites and reaction times was also obtained. Findings indicate a role of proton MRS as a measure of neuronal integrity following severe paediatric TBI and suggest a potential association of MRS with specific neuropsychological impairments.
Parry
Louise
L
Rehabilitation Department, The Children's Hosptial at Westmead, Australia.
Shores
Arthur
A
Rae
Caroline
C
Kemp
Allan
A
Waugh
Mary-Clare
MC
Chaseling
Ray
R
Joy
Pamela
P
D000293:Adolescent; D000367:Age Factors; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001930:Brain Injuries / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D002648:Child; D002794:Choline / Q000378:metabolism; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D003401:Creatine / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D009474:Neurons / Q000378:metabolism*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011930:Reaction Time; D012016:Reference Values; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline