title: Dopamine receptor and hypertension.
abstract: Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and reactive oxygen and by interacting with vasopressin, renin-angiotensin, and the sympathetic nervous system. Decreased renal dopamine production and/or impaired dopamine receptor function have been reported in hypertension. Disruption of any of the dopamine receptors (D(1), D(2), D(3), D(4), and D(5)) results in hypertension. In this paper, we review the mechanisms by which hypertension develops when dopamine receptor function is perturbed.
authors.affiliation: Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing City, P. R. China. cyzeng1@hotmail.com
authors.forename: Chunyu
authors.initials: C
authors.lastname: Zeng
authors.forename: Gilbert M
authors.initials: GM
authors.lastname: Eisner
authors.forename: Robin A
authors.initials: RA
authors.lastname: Felder
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Jose
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
chemical_list: D011954:Receptors, Dopamine; D012964:Sodium; D004298:Dopamine