[Clinical study on the antithrombotic effects of Holothuria ldeucospilota acidic mucopolysaccharide].
OBJECTIVE
To study the antithrombotic effects of Holothuria Ldeucospilota Acidic Mucopolysaccharide (HLAM).


METHODS
A series of variables were observed before and after treatment with HLAM in normal middle-aged subjects and patients recovering from cerebral embolism or suffering from ischemic heart disease, each of which were divided into two groups according to the dosage administered (60 mg/d and 120 mg/d).


RESULTS
The fat metabolism was enhanced in addition to the anticoagulant and the blood viscosity reducing effects. No side-effect was found.


CONCLUSIONS
HLAM is a promising drug for antithrombotic therapy.
Wang
X
X
Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025.
Wang
H
H
Hu
D
D
Li
J
J
Jin
C
C
Lu
S
S
Jiang
C
C
Qu
B
B
Li
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D016022:Case-Control Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000737:chemistry* / Q000494:pharmacology*; D006025:Glycosaminoglycans / Q000737:chemistry* / Q000494:pharmacology*; D047332:Holothuria / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D020766:Intracranial Embolism / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000378:metabolism
D005343:Fibrinolytic Agents; D006025:Glycosaminoglycans