title: Evaluation of long-term effects of endoscopic injection of collagen into the urethral submucosa for treatment of urethral sphincter incompetence in female dogs: 40 cases (1993-2000).
abstract: OBJECTIVE
  To evaluate long-term success of endoscopic injection of collagen into the urethral submucosa in female dogs with urinary incontinence caused by urethral sphincter incompetence.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  40 incontinent female dogs.
  
  
  METHODS
  Medical records were reviewed for outcome and other results for dogs in which a cystoscope was passed into the urethra for deposition of 3 collagen deposits into the submucosa.
  
  
  RESULTS
  27 (68%) dogs were continent for 1 to 64 months (mean, 17 months) after the collagen injection. In another 10 dogs, incontinence improved and in 6 of these dogs, full continence was regained with administration of additional medication. In 3 dogs, incontinence was unchanged. As long as 12 months after injection, there was a deterioration in the initial result in 16 dogs, after which their condition stabilized. Mild and transient adverse effects developed in 6 (15%) dogs.
  
  
  CONCLUSIONS
  Long-term success of endoscopic injection of collagen was satisfactory. Relapse of incontinence might be caused by flattening of the collagen deposits rather than resorption of the collagen.
authors.affiliation: Section of Small Animal Reproduction, Department of Small Animals, Faculty of Veterinary Medicine, Zurich University, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
authors.forename: Andrea
authors.initials: A
authors.lastname: Barth
authors.forename: Iris M
authors.initials: IM
authors.lastname: Reichler
authors.forename: Madeleine
authors.initials: M
authors.lastname: Hubler
authors.forename: Michael
authors.initials: M
authors.lastname: Hässig
authors.forename: Susi
authors.initials: S
authors.lastname: Arnold
mesh_terms: D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D014521:Urethra / Q000187:drug effects / Q000502:physiology; D014549:Urinary Incontinence / Q000628:therapy / Q000662:veterinary*; D014555:Urination Disorders / Q000628:therapy / Q000662:veterinary*; D014563:Urodynamics / Q000187:drug effects / Q000502:physiology
chemical_list: D003094:Collagen