DNA damage detection and repair, and the involvement of epigenetic states.
Chromatin is a highly dynamic structure that acts alternately as a substrate and a template in a number of critical biological processes. Modification of chromatin is pertinent and is responsible for a number of nuclear processes, including DNA repair, replication, transcription, and recombination. The purpose of this review is to discuss specific interactions between chromatin remodeling, DNA repair, and transcription. These areas are demonstrated to share commonality, particularly with a number of key molecules that appear to have roles in a number of pathways. The implications of pathway cross-over and communication form a seamless continuation of genomic integrity and stability.
Bassal
Sahar
S
Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Prahran, Australia.
El-Osta
Assam
A
D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000502:physiology; D051758:Transcription Factor TFIIH / Q000378:metabolism; D014158:Transcription, Genetic
D002843:Chromatin; D006657:Histones; D018809:Proliferating Cell Nuclear Antigen; D051758:Transcription Factor TFIIH