[The study on the effect of prostaglandins A1 on the replication of human immunodeficiency virus type 1 (HIV-1) in vitro].
We observed the effect of prostaglandins A1 (PGA1) on the replication of HIV-1 by Northern-blot method in the CEM-ss cells which had been infected with HIV-1. The results showed that the RNA levels of HIV-1 in infected cells treated with PGA1 was lower than that of controls in low MOI 72-96 hours postinfection. The RNA of HIV-1 was dramatically reduced in infected CEM-ss cells when PGA1 was given 24 hours postinfection. The inhibition effect of PGA1 lasted for 9 days when PGA1 was given constantly.
Lu
H
H
Institute of virology, Chinese Academy of Preventive Medicine, Beijing 100052.
Giorgi
C
C
Carattoli
A
A
D015152:Blotting, Northern; D045744:Cell Line, Tumor; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000502:physiology*; D006801:Humans; D011454:Prostaglandins A / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D011454:Prostaglandins A