Tau in neurodegenerative diseases: tau phosphorylation and assembly.
The possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment using a tau transgenic mouse model.
Avila
J
J
Centro de Biología Molecular Severo Ochoa (CSIC-UAM). Facultad de Ciencias.Campus de Cantoblanco. Universidad Autónoma de Madrid, 28049 Madrid, Spain. javila@cbm.uam.es
Pérez
M
M
Lim
F
F
Gómez-Ramos
A
A
Hernández
F
F
Lucas
J J
JJ
D000818:Animals; D002460:Cell Line; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D010766:Phosphorylation; D016875:tau Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D016875:tau Proteins