[Osteoclastogenesis Inhibitory Factor (OCIF) /Osteoprotegerin (OPG) as a new therapeutic agent for osteoporosis].
Osteoclastogenesis inhibitory factor (OCIF) is a novel member of the Tumor Necrosis Factor Receptor superfamily and identical with Osteoprotegerin (OPG) discovered by Amgen researchers. OCIF/OPG is a decoy receptor (a soluble receptor that acts as an antagonist) that binds to osteoblast cells via Receptor Activator of NF-kappa B Ligand (RANKL) involved in the signal transduction between osteoblast cells and osteoclastic progenitor cells, eventually suppressing differentiation of the progenitor cells into osteoclasts. The balance between the OCIF/OPG and RANKL is regulated by cytokines and hormones. Studies on OCIF/OPG-RANKL system have provided important insights into the pathogenesis of human metabolic bone diseases, leading to the expectation of OCIF/OPG as a novel candidate for a therapeutic agent for metabolic bone diseases.
Mochizuki
Shin-ichi
S
Biological Research Laboratories, Sankyo Co., Ltd., Japan.
Kiyokawa
Akiko
A
Nagayama
Yuki
Y
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002352:Carrier Proteins / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics; D002986:Clinical Trials as Topic; D015195:Drug Design; D006023:Glycoproteins / Q000737:chemistry / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D010006:Osteoblasts; D010010:Osteoclasts / Q000166:cytology; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology; D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000502:physiology / Q000627:therapeutic use; D018124:Receptors, Tumor Necrosis Factor; D015398:Signal Transduction / Q000235:genetics
D002352:Carrier Proteins; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; C505686:TNFRSF11A protein, human; C506030:TNFRSF11B protein, human; C505688:TNFSF11 protein, human