Notch signaling: a different sort makes the cut.
Notch signaling is regulated by ubiquitination of the receptor and its extracellular ligands. New studies reveal distinct ubiquitination-dependent endosomal sorting pathways in which ligand-bound Notch is activated while unliganded Notch is recycled or degraded, facilitating signaling while preventing inappropriate activation of unstimulated receptors.
Kanwar
Ritu
R
Laboratory of Protein Dynamics and Signaling, National Cancer Institute, 1050 Boyles Street, Frederick, Maryland 21701, USA.
Fortini
Mark E
ME
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
D002352:Carrier Proteins; D029721:Drosophila Proteins; C086679:DX protein, Drosophila; D008024:Ligands; D008565:Membrane Proteins; C497759:N protein, Drosophila; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D044767:Ubiquitin-Protein Ligases