Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica.
The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated. Activity-guided fractionation of MeOH extract resulted in the isolation of ursolic acid lactone, ursolic acid, pomolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid. Antiproliferative activity of the isolated compounds against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells was estimated.
Yoshida
Miyako
M
Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Fuchigami
Masahiro
M
Nagao
Tsuneatsu
T
Okabe
Hikaru
H
Matsunaga
Kazuhisa
K
Takata
Jiro
J
Karube
Yoshiharu
Y
Tsuchihashi
Ryota
R
Kinjo
Junei
J
Mihashi
Kunihide
K
Fujioka
Toshihiro
T
D019661:Apiaceae; D049109:Cell Proliferation / Q000187:drug effects*; D028041:Centella; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053630:Depsides; D006131:Growth Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000097123:Rosmarinic Acid
D002934:Cinnamates; D053630:Depsides; D006131:Growth Inhibitors; D010936:Plant Extracts; D014315:Triterpenes; D000097123:Rosmarinic Acid