Amiloride and the regulation of NF-kappaB: an unsung crosstalk and missing link between fluid dynamics and oxidative stress-related inflammation--controversy or pseudo-controversy?
Understanding the biophysics of fluid dynamics within the context of transcriptional regulation, mediated by nuclear factor (NF)-kappaB, is crucial to developing a consensus on the molecular basis of fluid mechanics and imbalance. Amiloride, an antikaliuretic-diuretic agent, has recently entered the realm of NF-kappaB as a key player in regulating the molecular association of fluid dynamics with inflammation and oxidative stress. With the identification of flanking regions encoding the amiloride-sensitive channels that are NF-kappaB-responsive, a new theme emerges which underlies the significance of this association. What is the role of NF-kappaB in regulating fluid mechanics-is it a physiologic or immunologic function? Conversely, amiloride is purported as a major regulator of this transcriptional pathway. It is the mainstream of this survey, therefore, to outline current advances on the biophysics and nature of the interaction existing between amiloride, amiloride-sensitive channels, and NF-kappaB, while searching for potential molecular mechanisms.
Haddad
John J
JJ
Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon. johnjhaddad@yahoo.co.uk <johnjhaddad@yahoo.co.uk>
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*
D004232:Diuretics; D016328:NF-kappa B; D000584:Amiloride