title: BDNF gene is a risk factor for schizophrenia in a Scottish population.
abstract: Schizophrenia is a severe psychiatric disease with a strong genetic component. Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of schizophrenia and bipolar (BP) disorders. The present study has examined two polymorphisms in linkage disequilibrium in the BDNF gene, which have been variously reported as associated with schizophrenia and BP. In our study, 321 probands with a primary diagnosis of schizophrenia or schizoaffective disorder, and 263 with a diagnosis of bipolar affective disorder, were examined together with 350 controls drawn from the same geographical region of Scotland. The val66met single-nucleotide polymorphism (SNP) showed significant (P = 0.005) association for valine (allele G) with schizophrenia but not bipolar disorder. Haplotype analysis of val/met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant (P < 1 x 10(-8)) under-representation of the methionine or met-1 haplotype in the schizophrenic but not the BP population. We conclude that, although the val66met polymorphism has been reported to alter gene function, the risk may depend upon the haplotypic background on which the val/met variant is carried.
authors.affiliation: Department of Mental Health, University of Aberdeen, Institute of Medical Science, Aberdeen, Scotland AB25 2ZD, UK.
authors.forename: M
authors.initials: M
authors.lastname: Neves-Pereira
authors.forename: J K
authors.initials: JK
authors.lastname: Cheung
authors.forename: A
authors.initials: A
authors.lastname: Pasdar
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Breen
authors.forename: P
authors.initials: P
authors.lastname: Yates
authors.forename: M
authors.initials: M
authors.lastname: Sinclair
authors.forename: C
authors.initials: C
authors.lastname: Crombie
authors.forename: N
authors.initials: N
authors.lastname: Walker
authors.forename: D M
authors.initials: DM
authors.lastname: St Clair
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008715:Methionine / Q000235:genetics; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012016:Reference Values; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*; D012606:Scotland; D014633:Valine / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine