[Detection and clinical significance of serum antibody to ribosomal P protein in patients with systemic lupus erythematosus].
OBJECTIVE
To observe the positive rate and its clinical significance of serum antibody to ribosomal P protein (anti-P) in patients with systemic lupus erythematosus (SLE).


METHODS
Anti-P protein antibody was detected by EURO blot with synthetic full-length ribosomal proteins, and then correlation between anti-P antibody, other autoantibodies and clinical characters was analysed .


RESULTS
In 150 SLE patients 36 cases (24%) were positive for anti-P antibody. The incidence of renal and central nervous system lesions in anti-P antibody-positive patients was notably higher than that in anti-P antibody-negative group. The positive rate of anti-P antibody was correlated with that of anti-dsDNA, anti-Sm and anti-RNP antibodies, but had no correlation with the lesions of skin, joint, blood and liver, nor indexes of disease's activity (DAI).


CONCLUSIONS
There is correlation between anti-P antibody level with renal and CNS lesions in SLE patients.
Wu
Zhen-Biao
ZB
Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an 710004, China.
Zhu
Ping
P
Wang
Yan-Hong
YH
Leng
Nan
N
Fan
Chun-Mei
CM
Zhang
Hui-Qin
HQ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood* / Q000276:immunology*; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D007668:Kidney / Q000276:immunology / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012269:Ribosomal Proteins / Q000276:immunology*
D000906:Antibodies; D012269:Ribosomal Proteins