title: Antiinflammatory activity of astilbic acid from Astilbe chinensis.
abstract: This study examined the effect of astilbic acid (3beta,6beta-dihydroxyolean-12-en-27-oic acid), which is a herbal medicine isolated from Astilbe chinensis. Astilbic acid inhibited 5-lipoxygenase (5-LOX)-dependent leukotriene C4 (LTC4) generation in bone marrow-derived mast cells in a concentration-dependent manner with an IC50 value of 2.1 microM. In addition, astilbic acid was tested in a rat passive cutaneous anaphylaxis (PCA) reaction assay by administering 10 to 50 mg/kg i.p. Astilbic acid dose dependently inhibited the PCA reaction, which was activated by anti-dinitrophenyl (DNP) IgE. Furthermore, this compound inhibited mouse acetic acid-induced writhing (47-62% inhibition at 0.4-50 mg/kg) after being administered orally, while aspirin (200 mg/kg) showed 62% inhibition. These results suggest that astilbic acid may be beneficial in regulating various inflammatory processes.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyongsan, Korea.
authors.forename: Tae Chul
authors.initials: TC
authors.lastname: Moon
authors.forename: Chang Xiu
authors.initials: CX
authors.lastname: Lin
authors.forename: Joo Sang
authors.initials: JS
authors.lastname: Lee
authors.forename: Dong Seon
authors.initials: DS
authors.lastname: Kim
authors.forename: Kihwan
authors.initials: K
authors.lastname: Bae
authors.forename: Kun Ho
authors.initials: KH
authors.lastname: Son
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Kim
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Jong Keun
authors.initials: JK
authors.lastname: Son
authors.forename: Hyeun Wook
authors.initials: HW
authors.lastname: Chang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D028321:Plant Preparations / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C494851:3beta,6beta-dihydroxyolean-12-en-27-oic acid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D028321:Plant Preparations; D009828:Oleanolic Acid