[Report of a rare distal arthrogrophy large family].
We describe a seven-generation large family with talipomanus and talipes, 175 individuals in this family were involved. 32 affected individuals including 18 males and 14 females whose clinical features were different and 1 suspicious male were found. The talipomanus were symmetrical, and varus and valgus were caused by vertical talus. We investigated their living environment, the dietary habit, obstetrical history, physical status, lifespan, and studied cytogenetics and so on. We propose these defects were rare distal arthrogrophy genetic disease.
Jiang
Miao
M
Liaoning Open Laboratory of Reproductive Medicine, Shenyang 110031,China. jiangmiaocpt@yahoo.com.cn
Han
Wei-Tian
WT
Bian
Chao-Ying
CY
Wang
Ge
G
Li
Wei-Zhou
WZ
Sun
Li-Na
LN
Yang
Ze
Z
D000328:Adult; D001176:Arthrogryposis / Q000235:genetics* / Q000473:pathology*; D005192:Family Health; D005260:Female; D005532:Foot Deformities, Congenital / Q000000981:diagnostic imaging / Q000235:genetics; D006228:Hand Deformities, Congenital / Q000000981:diagnostic imaging / Q000235:genetics; D006801:Humans; D008297:Male; D010375:Pedigree; D011859:Radiography