title: [Antimicrobial susceptibility testing of clinical isolates of Haemophilus influenzae derived from Japanese children].
abstract: We examined the antimicrobial susceptibility testing of 1,024 Haemophilus influenzae isolates recovered from Japanese children. Percent distribution of beta-lactamase-negative ampicillin (ABPC)--resistant strain (BLNAR; ABPC-MIC > or = 4 microg/ml) was 15.0%. Prevalence of BLNAR increased remarkably from 12.7 to 22.1% in recent 4 years. Furthermore, the frequency of highly resistant strains (ABPC-MIC > or = 8 microg/ml) increased from 28.6 to 56.9% among BLNAR. Decreased susceptibility for cephems was observed in non-BLNAR strains including serotype b strain isolated from the cerebrospinal fluid.
authors.affiliation: Division of Infectious Diseases, Chiba Children's Hospital.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hoshino
authors.forename: Fusayo
authors.initials: F
authors.lastname: Sudo
authors.forename: Kyoko
authors.initials: K
authors.lastname: Sawada
authors.forename: Saori
authors.initials: S
authors.lastname: Sueyoshi
authors.forename: Akira
authors.initials: A
authors.lastname: Nakamura
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male
chemical_list: D000667:Ampicillin