title: A new approach to strip-based tooth whitening: 14% hydrogen peroxide delivered via controlled low dose.
abstract: Professionally dispensed, take-home whitening products originally consisted of tray systems into which the patient dispensed a peroxide-containing gel. Because the process of inserting peroxide-containing gels into the trays is patient controlled, the resulting exposure of the gingiva to peroxide can be variable, and often high. In addition to concentration, soft tissue irritation is a function of the amount, or dose, of peroxide with which the tissue is challenged. All other things being equal, higher-concentration products will whiten faster because of the peroxide concentration gradient, but they also will lead to poorer soft tissue tolerability because of a higher peroxide challenge. Consequently, take-home trays are somewhat limited with respect to the concentration of hydrogen peroxide that they can safely use. In 2000, strip-based whitening technology was introduced that allowed a controlled, uniform, low dose of peroxide to be applied to the teeth. An execution of this strip-based technology that contained 6.5% hydrogen peroxide, Crest Professional Whitestrips, was launched in 2001. A new professionally dispensed strip product, Crest Whitestrips Supreme, recently has been introduced. A 14% hydrogen-peroxide gel is incorporated onto these strips, but the amount of gel is half of what is on the 6.5% strips. The net result is that the dose, or amount, of peroxide on each strip is essentially the same as for the Professional Whitestrips product. Therefore, the 14% hydrogen-peroxide strip product whitens faster and better than previous strip products, while still being well tolerated by the soft tissue.
authors.affiliation: The Procter & Gamble Company, Mason, Ohio, USA.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sagel
authors.forename: William F
authors.initials: WF
authors.lastname: Landrigan
mesh_terms: D000077463:Carbamide Peroxide; D003258:Consumer Behavior; D003742:Dental Devices, Home Care; D003743:Dental Enamel / Q000187:drug effects*; D004338:Drug Combinations; D016503:Drug Delivery Systems; D004955:Esthetics, Dental; D005782:Gels / Q000008:administration & dosage*; D005881:Gingiva / Q000187:drug effects*; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage*; D010545:Peroxides / Q000008:administration & dosage; D014073:Tooth Bleaching / Q000379:methods*; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: C488279:Crest whitestrips; D004338:Drug Combinations; D005782:Gels; D010545:Peroxides; D000077463:Carbamide Peroxide; D014508:Urea; D006861:Hydrogen Peroxide