title: Induction of epileptic negative myoclonus by oxcarbazepine in symptomatic epilepsy.
abstract: Provocation of various seizure types including epileptic negative myoclonus and generalised atonic seizures is rarely observed in children treated with carbamazepine (CBZ). Provocation of the latter seizure types by oxcarbazepine (OXC) is not described in the literature. We report a four year-old boy with symptomatic epilepsy caused by left-sided cerebral atrophy of unknown origin who developed numerous daily drop attacks when exposed to OXC. Polygraphic analysis revealed secondary generalised precentral sharp-slow waves frequently associated with a silent period lasting for 100-150 ms in the electromyogram recorded from the deltoid and neck muscles. These seizures stopped promptly within 36 hours after discontinuation of OXC. This case demonstrates that OXC, similar to CBZ, can provoke epileptic negative myoclonus in some children with focal epilepsies. [Published with videosequences].
authors.affiliation: Department of Neuropediatrics, University of Giessen, Germany. andreas.hahn@paediat.med.uni-giessen.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Hahn
authors.forename: Anke
authors.initials: A
authors.lastname: Fischenbeck
authors.forename: Ulrich
authors.initials: U
authors.lastname: Stephani
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001284:Atrophy; D002220:Carbamazepine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002540:Cerebral Cortex / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004292:Dominance, Cerebral / Q000502:physiology; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects*; D004576:Electromyography / Q000187:drug effects; D004831:Epilepsies, Myoclonic / Q000139:chemically induced* / Q000175:diagnosis; D004829:Epilepsy, Generalized / Q000175:diagnosis / Q000188:drug therapy*; D005071:Evoked Potentials / Q000187:drug effects; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009334:Neck Muscles / Q000294:innervation; D000078330:Oxcarbazepine; D013575:Syncope / Q000139:chemically induced / Q000175:diagnosis; D013686:Telemetry; D014741:Video Recording
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D000078330:Oxcarbazepine