title: Role of veins in regulation of pulmonary circulation.
abstract: Pulmonary veins have been seen primarily as conduit vessels; however, over the past two decades, a large amount of evidence has accumulated to indicate that pulmonary veins can exhibit substantial vasoactivity. In this review, the role of veins in regulation of the pulmonary circulation, particularly during the perinatal period and under certain pathophysiological conditions, is discussed. In the fetus, pulmonary veins contribute a significant fraction to total pulmonary vascular resistance. At birth, the veins as well as the arteries relax in response to endothelium-derived nitric oxide and dilator prostaglandins, thereby assisting in the fall in pulmonary vascular resistance. These effects are oxygen dependent and modulated by cGMP-dependent protein kinase. Under chronic hypoxic conditions, pulmonary veins undergo remodeling and demonstrate substantial constriction and hypertrophy. In a number of species, including the human, pulmonary veins are also the primary sites of action of certain vasoconstrictors such as endothelin and thromboxane. In various pathological conditions, there is an increased synthesis of these vasoactive agents that may lead to pulmonary venous constriction, increased microvascular pressures for fluid filtration, and formation of pulmonary edema. In conclusion, the significant role of veins in regulation of the pulmonary circulation needs to be appreciated to better prevent, diagnose, and treat lung disease.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Harbor-UCLA Research and Education Institute, 1124 W. Carson St., RB-1, Torrance, CA 90502, USA.
authors.forename: Yuansheng
authors.initials: Y
authors.lastname: Gao
authors.forename: J Usha
authors.initials: JU
authors.lastname: Raj
mesh_terms: D000208:Acute Disease; D000818:Animals; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D011651:Pulmonary Artery / Q000502:physiology / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000502:physiology*; D011654:Pulmonary Edema / Q000209:etiology; D011667:Pulmonary Veins / Q000502:physiology* / Q000503:physiopathology; D014655:Vascular Resistance; D014661:Vasoconstriction; D014662:Vasoconstrictor Agents / Q000378:metabolism; D014665:Vasodilator Agents / Q000378:metabolism
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents