title: Advancements in the diagnosis of acute appendicitis in children and adolescents.
abstract: The aim of our study was to further improve the preoperative diagnosis of acute appendicitis in children and adolescents. All diagnostic parameters from the patients' medical history (duration and quality of abdominal pain, stool behaviour), the laboratory (leukocytes, C-reactive protein), the clinic (defense, tenderness on percussion, nausea, vomiting, dry tongue) and repeated ultrasound investigations (visualisation of the appendix, indirect signs of an inflammatory process in the appendix region) were documented prospectively and were re-assessed with regard to their diagnostic value. As an additional parameter, procalcitonin was determined. 1156 patients (593 male/563 female) with a mean age of 9.51 years (+/- 1.2 yrs) (max. 15 yrs/min. 2.3 yrs), referred to the department with acute abdominal pain, were examined. 233 (141 male/92 female; 20.1 %) of these patients with a mean age of 10.47 years (+/- 1.1 yr) had appendicitis. Based on the patients' medical history, laboratory findings, the initial clinical investigation and the initial ultrasound investigation, 173 patients (74.3 % of the later operated 233 children with appendicitis) were diagnosed with certainty. The diagnosis of 60 patients (25.7 %) of this group remained uncertain. These patients received a saline enema (Clysmol, Pharmacia & Upjohn Company) and were subjected to a second clinical and sonographic investigation after approximately four hours of parenteral fluid substitution (Ringer's lactate, Mayrhofer Pharmazeutika Company, 4 ml/kg/h). The other 923 patients (79.83 %) were discharged and were followed up as outpatients in the following days. Based on this stepwise procedure, the percentage of correctly diagnosed appendicitis could be increased to 97.4 %. The measurement of procalcitonin proved to be of no value in the diagnosis of acute appendicitis. It may be concluded that in children with abdominal pain, high diagnostic accuracy can only be achieved by a carefully combined evaluation of all individual diagnostic parameters and repeated investigations.
authors.affiliation: Department of Paediatric Surgery, Donauspital, Langobardenstrasse 122, 1220 Vienna, Austria. edmund.blab@wienkav.at
authors.forename: E
authors.initials: E
authors.lastname: Blab
authors.forename: U
authors.initials: U
authors.lastname: Kohlhuber
authors.forename: S
authors.initials: S
authors.lastname: Tillawi
authors.forename: M
authors.initials: M
authors.lastname: Schweitzer
authors.forename: G
authors.initials: G
authors.lastname: Stangl
authors.forename: E
authors.initials: E
authors.lastname: Ogris
authors.forename: A
authors.initials: A
authors.lastname: Rokitansky
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000465:Algorithms; D001064:Appendicitis / Q000175:diagnosis*; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D010147:Pain Measurement; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood
chemical_list: C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide