title: Addition of hand-blended generic tobramycin in bone cement: effect on mechanical strength.
abstract: This study compared the mechanical strength of commercially prepared antibiotic bone cement (Simplex With Tobramycin; Stryker, Mahwah, NJ), cement with generic tobramycin (Pharma-Tek, Huntington, NY) blended in by the orthopedic nursing staff, and standard nonantibiotic bone cement. The results showed an approximate 36% decrease in the strength of the cement with hand-mixed generic tobramycin, while the commercial antibiotic cement remained unchanged relative to the nonantibiotic control. These results indicate the mechanical properties of bone cement can be severely compromised by hand-mixing antibiotics into bone cement at the time of surgery.
authors.affiliation: Stryker Orthopaedics, 325 Corporate Dr, Mahwah, NJ 07430, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: DeLuise
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Scott
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D020366:Methylmethacrylate / Q000737:chemistry / Q000494:pharmacology; D013314:Stress, Mechanical; D013718:Tensile Strength; D014031:Tobramycin / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D020366:Methylmethacrylate; D014031:Tobramycin