title: Philadelphia chromosome-positive acute lymphoblastic leukemia rescued with a second allogeneic stem cell transplantation from a haploidentical mother after relapse following cord blood transplantation.
abstract: A 32-year-old female patient who had Philadelphia chromosome-positive acute lymphoblastic leukemia underwent cord blood transplantation while in her second remission. However, she had a hematological and central nervous system relapse 3 months later. After reinduction with imatinib mesylate, unmanipulated peripheral blood stem cell transplantation was performed from the patient's haploidentical mother with a reduced-intensity conditioning regimen. Rabbit antithymocyte globulin, tacrolimus, and methylprednisolone were used for prophylaxis of graft-versus-host disease. Engraftment of neutrophils was observed on day 12, and complete donor chimerism was obtained by day 24. The posttransplantation course was uneventful. Although the patient had a relapse 10 months later, this case demonstrated that transplantation from a haploidentical donor is clearly a feasible alternative for patients who desperately need rescue transplantation.
authors.affiliation: Hematology, Kita-Fukushima Medical Center, Date, Fukushima, Japan. kai@jinsenkai.or.jp
authors.forename: Tatsuyuki
authors.initials: T
authors.lastname: Kai
authors.forename: Hideo
authors.initials: H
authors.lastname: Kimura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shiga
authors.forename: Shin
authors.initials: S
authors.lastname: Mineishi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoshihara
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ogawa
authors.forename: Etsuko
authors.initials: E
authors.lastname: Maruya
authors.forename: Hiroh
authors.initials: H
authors.lastname: Saji
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ohto
authors.forename: Yukio
authors.initials: Y
authors.lastname: Maruyama
mesh_terms: D000328:Adult; D000818:Animals; D036101:Cord Blood Stem Cell Transplantation; D005260:Female; D006239:Haplotypes; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D009035:Mothers; D036102:Peripheral Blood Stem Cell Transplantation; D011817:Rabbits; D011859:Radiography; D012074:Remission Induction; D018183:Transplantation Chimera; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous; D016896:Treatment Outcome