title: Solitary fibrous tumor of the uterus producing high-molecular-weight insulin-like growth factor II and associated with hypoglycemia.
abstract: We report a case of solitary fibrous tumor of the uterus producing high-molecular-weight insulin-like growth factor II (big IGF-II). A 78-year-old woman presented with a massive uterine tumor and worsening hypoglycemia. Endocrine and metabolic investigations revealed that her serum contained big IGF-II. Pathologic examination of the myometrial tumor showed spindle cells separated by thick collagen fibers. The tumor cells were immunoreactive for CD34 and IGF-II (inclusive of big IGF-II) but not smooth muscle actin or desmin. Postoperatively the hypoglycemia and the serum big IGF-II disappeared with recovery of suppressed insulin and growth hormone levels. Western blotting of the tumor extract revealed the presence of big IGF-II, the molecular weight of which was similar to that of aberrant serum IGF-II. To our knowledge, this is the first case of uterine solitary fibrous tumor.
authors.affiliation: Department of Pathology, Nagoya City University Medical School, Kawasumi 1, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Wakami
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tateyama
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kawashima
authors.forename: Tsuguo
authors.initials: T
authors.lastname: Matsuno
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kamiya
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Jin-No
authors.forename: Genjiro
authors.initials: G
authors.lastname: Kimura
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Eimoto
mesh_terms: D000368:Aged; D015153:Blotting, Western; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007335:Insulin-Like Growth Factor II / Q000096:biosynthesis* / Q000737:chemistry; D008970:Molecular Weight; D018218:Neoplasms, Fibrous Tissue / Q000150:complications / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014594:Uterine Neoplasms / Q000150:complications / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery
chemical_list: D007335:Insulin-Like Growth Factor II