title: Convergent approach to (E)-alkene and cyclopropane peptide isosteres.
abstract: Trisubstituted (E)-alkene isosteres (TEADIs) and novel cyclopropane amide bond isosteres (CPDIs) were synthesized by aldimine addition and three-component aldimine addition-cyclopropanation methodologies, respectively. These new peptide mimetics can serve as beta-turn promoters.
authors.affiliation: Department of Chemistry and Center for Chemical Methodologies & Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf@pitt.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
authors.forename: Jingbo
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000475:Alkenes; D003521:Cyclopropanes; D010455:Peptides