Adult-onset epilepsy and history of childhood febrile seizures: a retrospective study.
BACKGROUND
Children with febrile seizures (FS) are at higher risk of developing epilepsy. There is robust literature on epilepsy with onset in childhood following FS but very little on the same issue in adults.


OBJECTIVE
We intended to assess the association between adult-onset epilepsy and history of childhood FS.


METHODS
The neurology clinic of a university hospital.


METHODS
A retrospective study.


METHODS
Records of 101 consecutive adults (>14 years old) who were referred to our hospital with adult-onset seizures were reviewed and the patients and their families were interviewed to assess the medical history.


METHODS
Chi-square test and Mantel-Haenszel method.


RESULTS
Of the 101 patients, 9 were excluded for reasons of bacterial meningitis, recent head trauma, brain tumor, tricyclic antidepressants' overdose and missing reliable data of the childhood FS event. Thirty-one (33.7%) of the remaining 92 patients had history of FS in the childhood (71% men). Localization-related epilepsies were significantly associated with history of FS [Odds ratio: 3.29; (95% CI, 1.30-8.06)] ( (2)= 5.49, df = 1, P=0.012) when compared to other epilepsies and epilepsy syndromes. An initial unprovoked simple partial seizure was also significantly associated with a positive history of FS [Odds ratio: 8.05; (95% CI 2.88-22.45)] ( (2)= 15.86, df = 1, P< 0.001).


CONCLUSIONS
Localization-related epilepsies and partial seizures seem to be associated with a history of FS in childhood. This warrants more investigation to understand the mechanism as well as a possible pathology common in both localization-related epilepsies and FS in the affected probands.
Mohebbi
Mohammad R
MR
Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran. mrmohebbi@yahoo.com
Navipour
Reza
R
Seyedkazemi
Mojdeh
M
Zamanian
Hadi
H
Khamseh
Fatemeh
F
D000328:Adult; D017668:Age of Onset; D002648:Child; D004827:Epilepsy / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D012189:Retrospective Studies; D003294:Seizures, Febrile / Q000150:complications* / Q000453:epidemiology / Q000209:etiology