[The relationship between hyperfibrinogenemia and severity of coronary heart disease].
OBJECTIVE
To study the relationship between serum advanced fibrinogen and the severity of coronary artery stenosis.


METHODS
In a collection of 195 patients suspected of coronary artery disease (CAD), coronary artery stenosis was studied with coronary angiography. The severity of coronary artery disease was quantified with a modified Gensini score on the basis of angiographic imaging manipulation system. Fibrinogen, total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and D-dimer were determined in all the patients. After the influences of other risk factors were controlled, the relationship between fibrinogen and severity of CAD was analyzed.


RESULTS
Partial correlation analysis showed that fibrinogen was positively correlated with the severity of CAD (r = 0.293, P < 0.01). Multiple stepwise regression analysis indicated that fibrinogen and age were significant variables associated with the severity of coronary artery disease (F value was 16.89, 15.47, P < 0.01; R was 0.29, 0.38, P < 0.01). All the patients were assigned to one of four groups according to fibrinogen level with 25, 50 and 75 percentile as cut-off points. We found that high fibrinogen level was associated with severe coronary artery disease, particularly in men and in diabetes mellitus patients.


CONCLUSIONS
Elevated fibrinogen level is related to the severity of CAD.
Liu
Mei-Yan
MY
Department of Cardiology, People's Hospital, Peking University, Beijing 100044, China.
Hu
Da-Yi
DY
Yan
Li
L
Liu
Wen-Hong
WH
Liu
Ru-Hui
RH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002784:Cholesterol / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood
D005338:Fibrin Fibrinogen Degradation Products; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; C036309:fibrin fragment D; D005340:Fibrinogen; D002784:Cholesterol