Continuous synthesis of aminophenols from nitroaromatic compounds by combination of metal and biocatalyst.
The combined action of immobilized hydroxylaminobenzene mutase and zinc in a flow-through system catalyzes the conversion of nitroaromatic compounds to the corresponding ortho-aminophenols, including a novel analog of chloramphenicol.
Luckarift
Heather R
HR
Air Force Research Laboratory, 139 Barnes Drive, Suite #2, Tyndall AFB, FL 32403-5323, USA.
Nadeau
Lloyd J
LJ
Spain
Jim C
JC
D000627:Aminophenols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004800:Enzymes, Immobilized / Q000737:chemistry*; D019751:Intramolecular Transferases / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D000627:Aminophenols; D004800:Enzymes, Immobilized; D009574:Nitro Compounds; D019751:Intramolecular Transferases; C412734:hydroxylaminobenzene mutase; D015032:Zinc