Possible new role of monocyte chemoattractant protein-1 in hemodialysis patients with cardiovascular disease.
OBJECTIVE
Reactive oxygen species have been implicated in increased vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein (MCP-1) levels in vascular cells, which may promote atherosclerosis progression.


METHODS
We studied the association between pre-dialysis plasma levels of VEGF and MCP-1 in 45 hemodialysis (HD) patients with and without cardiovascular disease (CVD) in conditions of increased oxidative stress (SOX).


RESULTS
Compared to the controls, HD patients, especially those with CVD, showed a significant increase in plasma concentrations of Cu/Zn superoxide dismutase (Cu/Zn SOD), C-reactive protein (CRP), MCP-1 and VEGF. The levels of CRP, MCP-1 and VEGF were more increased in patients with CVD than in patients without CVD (all p < 0.01). VEGF strongly and positively correlated with MCP-1 only in HD patients with CVD. Additionally, both VEGF and MCP-1 were associated with Cu/Zn SOD in the whole HD group.


CONCLUSIONS
For the first time our data indicate a correlation between VEGF and MCP-1 levels in HD patients with CVD in conditions of increased SOX. This interaction may reflect the new role of MCP-1 as an arteriogenic factor in HD patients with CVD.
Pawlak
Krystyna
K
Department of Nephrology and Clinical Transplantation, Medical University, Białystok, Poland. krystynapawlak@poczta.onet.pl
Pawlak
Dariusz
D
Mysliwiec
Michal
M
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000453:epidemiology / Q000276:immunology*; D018932:Chemokine CCL2 / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D006435:Renal Dialysis; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
D018932:Chemokine CCL2; D042461:Vascular Endothelial Growth Factor A; D013482:Superoxide Dismutase