[Advances of nuclear translation factor:peroxisome proliferator-actived receptor gamma2].
Peroxisome proliferator-actived receptor gamma2(PPARgamma2) is a translation factor that belongs to the superfamily of nuclear receptors. It expresses predominantely in adipose tissue and has a key role in adipocyte differentiation. The common Pro12Ala polymorphism is associated closely with obesity and type 2 diabetes. It is the target molecular of thiazolidinediones which is a novel class of insulin sensitizer. The study of PPARgamma2 molecular mechanism of metabolism control may accelerate the finding of new drug targets in prevention and therapeution of type 2 diabetes.
Sun
Yu-Ru
YR
National Institute of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China.
Yang
Ze
Z