title: Inhibitory activity of shiitake flavor against platelet aggregation.
abstract: Sulfuric-flavored compounds were extracted from shiitake (Lentinus edodes) and their inhibitory activity against platelet aggregation was investigated. Platelet aggregation induced by arachidonic acid and U-46619, the analog of thromboxane A(2), was inhibited by the essential oil from shiitake that contained lenthionine as a major sulfuric compound. This result indicates that the inhibitory site of the shiitake flavor compounds would be different from that of garlic-flavor compounds because the latter inhibits the passage between arachidonic acid and thromboxane A(2). The effect of the synthesized lenthionine was almost equivalent to that of the essential oil, which indicates that the inhibitory activity of the essential oil from shiitake would be mainly attributed to lenthionine.
authors.affiliation: Department of Agricultural and Biological Chemistry, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi 252-8510, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Shimada
authors.forename: Koji
authors.initials: K
authors.lastname: Komamura
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kumagai
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Sakurai
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000494:pharmacology; D000328:Adult; D016718:Arachidonic Acid / Q000494:pharmacology; D005421:Flavoring Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D012016:Reference Values; D020942:Shiitake Mushrooms; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D005421:Flavoring Agents; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D014662:Vasoconstrictor Agents; D016718:Arachidonic Acid; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid