Synthesis of structurally diverse and defined bivalent mannosides on saccharide scaffolding.
[Structure: see text] The synthesis of bivalent mannosides by the grafting of alpha-D-mannopyranoside onto monosaccharide acceptors and conjugation to terephthalic acid or phenylenediamine is described. Computational methods were used to predict accessible orientations and distances between the mannose units.
Tosin
Manuela
M
Centre for Synthesis and Chemical Biology, Chemistry Department, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
Gouin
Sebastien G
SG
Murphy
Paul V
PV
D002240:Carbohydrate Sequence; D003198:Computer Simulation; D008362:Mannosides / Q000138:chemical synthesis* / Q000737:chemistry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry*; D010655:Phenylenediamines / Q000737:chemistry*; D010795:Phthalic Acids / Q000737:chemistry*
D008362:Mannosides; D009005:Monosaccharides; D010655:Phenylenediamines; D010795:Phthalic Acids; C011363:terephthalic acid