title: [A prospective study of relationship between blood pressure and 10-year cardiovascular risk in a Chinese cohort aged 35-64 years].
abstract: OBJECTIVE
  To provide epidemiological data for the revision of The National Guideline for Prevention and Treatment of Hypertension through the analysis of the association between blood pressure (BP) and the risk of cardiovascular diseases (CVD) in a cohort aged 35-64 years.
  
  
  METHODS
  A prospective study was carried out in 11 provinces from 1992 to 2002. The association between BP and CVD (CHD and stroke) was analyzed in 31728 subjects aged 35 - 64 years.
  
  
  RESULTS
  (1) Compared with BP < 110/75 mmHg, the risk of CVD increased 1 time (RR=2.09), 2 times (RR=3.23), and 10 times (RR=11.81) when BP was 120-129/80-84 mmHg, 140-149/90-94 mmHg, and > or = 180/110 mm Hg, respectively. (2) The risk of acute CHD for subjects with stage 2 hypertension was 2.3 times of those with optimal BP, whereas the risk of ischemic stroke and hemorrhagic stroke was 4.9 times and 11.7 times, respectively. (3) 36.1% of all CVDs, 44.0% of the acute stroke and 23.7% of the acute CHD were attributable to hypertension. (4) In each BP level, the 10-year risk of CVD increased with the increased number of other risk factors.
  
  
  CONCLUSIONS
  The risk of CVD increases with BP continuously from BP of 110/75 mmHg. Therefore, the cutpoint of the diagnostic criteria for hypertension is arbitrary. Comprehensive intervention for multiple risk factor clustering should be strengthened to reduce the overall risk of CVD.
authors.affiliation: Department of Epidemiology, Capital Medical University Affiliated Anzhen Hospital, Institute of Beijing Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Jia-yi
authors.initials: JY
authors.lastname: Sun
authors.forename: Gui-xian
authors.initials: GX
authors.lastname: Wu
authors.forename: Zhe-chun
authors.initials: ZC
authors.lastname: Zeng
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Lan-ping
authors.initials: LP
authors.lastname: Qin
authors.forename: Zhao-su
authors.initials: ZS
authors.lastname: Wu
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003327:Coronary Disease / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology* / Q000503:physiopathology