title: [Synthesis and the drug release properties of poly(acrylamide-co-glycosylallylamide) hydrogels].
abstract: Sugar-containing monomer glycosylallylamide (AAG) was synthesized by allyl amine and delta-gluconolactone in dimethylformamide (DMF) solution. The sugar-based hydrogels were prepared by free radical crosslinking copolymerization of AAG and acrylamide (AM). The release properties of Aspirin from xerogels matrices were studied and the release mechanism of Aspirin was further identified by evaluating the n value in Peppas equation. The results indicate that the drug release decreases with the increase of the sugar content of hydrogel.
authors.affiliation: School of Pharmaceutics, Shandong University, Ji'nan 250012, China. cn-lbli@263.sina.com
authors.forename: Lingbing
authors.initials: L
authors.lastname: Li
authors.forename: Yebang
authors.initials: Y
authors.lastname: Tan
authors.forename: Jianwen
authors.initials: J
authors.lastname: Meng
mesh_terms: D020106:Acrylamide / Q000138:chemical synthesis / Q000737:chemistry*; D001241:Aspirin / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D005942:Gluconates / Q000138:chemical synthesis / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D007783:Lactones; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D005942:Gluconates; D020100:Hydrogels; D007783:Lactones; D011108:Polymers; D020106:Acrylamide; D001241:Aspirin; C010730:beta-glucono-1,5-lactone