Interfering with cancer: a brief outline of advances in RNA interference in oncology.
RNA interference (RNAi) is a potent and ubiquitous gene-silencing mechanism that is generating considerable excitement in the fields of molecular biology and gene therapy. It is now in widespread use for loss-of-function analysis in many diseases including cancer. Nevertheless, RNAi is still in its infancy, with new discoveries appearing on a monthly basis. This article presents a brief outline of the history and recent advances in RNAi with a specific focus on its potential in oncology.
Rye
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Axis Shield ASA, Ulvenveien 87, NO-0581 Oslo, Norway. phil.rye@no.axis-shield.com
Stigbrand
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D015316:Genetic Therapy; D006801:Humans; D008495:Medical Oncology / Q000639:trends; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D034622:RNA Interference