title: Sleeve sensor versus high-resolution manometry for the detection of transient lower esophageal sphincter relaxations.
abstract: Transient lower esophageal sphincter relaxations (TLESRs) are the most important mechanism by which gastroesophageal reflux occurs, and sleeve sensor manometry is the gold standard for detection of TLESRs. The aim of this study was to evaluate manometry with closely spaced sideholes (high-resolution manometry) for the detection of TLESRs as an alternative. In 12 patients with gastroesophageal reflux disease, a 90-min postprandial manometry was performed by using a catheter incorporating both a sleeve sensor and closely spaced sideholes in the esophagogastric junction. TLESRs recorded with both techniques were scored. Reflux during TLESRs was detected by using manometry (common cavity), intraluminal impedance, and pH monitoring. A total of 145 TLESRs were detected by using both techniques, 117 with high-resolution manometry and 108 with sleeve sensor manometry [not significant (NS)]. Manometric signs of reflux during TLESRs detected with high-resolution and sleeve sensor manometry were found in 62.4 and 56.5%, NS, respectively, versus 38.5 and 35.2%, NS on pH-metry and 70.1 and 60.2%, NS on impedance monitoring. TLESRs recognized only with high-resolution manometry were more often accompanied by reflux, as detected with manometry (59.5%) and impedance monitoring (67.6%), than TLESRs recognized only with sleeve sensor manometry (32.1 and 28.6%). High-resolution manometry is at least as accurate as sleeve sensor manometry for the detection of TLESRs.
authors.affiliation: Dept. of Gastroenterology, St. Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, The Netherlands. a.bredenoord@antonius.net
authors.forename: A J
authors.initials: AJ
authors.lastname: Bredenoord
authors.forename: B L A M
authors.initials: BL
authors.lastname: Weusten
authors.forename: R
authors.initials: R
authors.lastname: Timmer
authors.forename: A J P M
authors.initials: AJ
authors.lastname: Smout
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D017097:Electric Impedance; D004947:Esophagus / Q000502:physiology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods / Q000592:standards; D008875:Middle Aged; D012680:Sensitivity and Specificity