Anthocyan does not suppress transformation of aryl hydrocarbon receptor induced by dioxin.
Dioxins cause a variety of toxic effects through transformation of a cytosolic aryl hydrocarbon receptor (AhR). We have previously demonstrated that certain natural flavones and flavonols at the dietary levels suppress AhR transformation. In this study, we investigated whether 5 anthocyanidins, 15 anthocyanins, and protocatechuic acid suppress AhR transformation in mouse hepatoma Hepa-1c1c7 cells. All the compounds tested here at 5 microM unexpectedly failed to suppress the transformation induced by 0.1 nM TCDD, indicating that anthocyan does not have a potential to prevent dioxin toxicity.
Mukai
Rie
R
Laboratory of Food and Nutritional Chemistry, Faculty of Agriculture, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8501, Japan.
Fukuda
Itsuko
I
Nishiumi
Shin
S
Hosokawa
Keizo
K
Kanazawa
Kazuki
K
Ashida
Hitoshi
H
D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D062385:Hydroxybenzoates / Q000494:pharmacology; D008113:Liver Neoplasms; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D018336:Receptors, Aryl Hydrocarbon / Q000096:biosynthesis* / Q000187:drug effects
D000872:Anthocyanins; D062385:Hydroxybenzoates; D010936:Plant Extracts; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; C009091:protocatechuic acid