title: [Drug allergies. Clinical aspects, pathophysiology and treatment of cutaneous manifestations].
abstract: Cutaneous adverse drug reactions (ADR) are common and encompass a broad clinical spectrum. Since the skin acts as a signaling organ for ADR, the dermatologist plays a key role in their diagnosis. Only a minor part of cutaneous ADR are due to underlying allergic mechanisms. Among these, delayed-type reactions such as maculopapular exanthems and immediate-type reactions such as urticaria and angioedema predominate. Risk factors for the development of cutaneous allergic ADR may be related to the patient (e.g. certain HLA-types), the drug (e.g. its reactivity), and underlying conditions (e.g. viral infections). Antibiotics, non-steroidal anti-inflammatory agents and anticonvulsive medications are most often reported to be causally related.
authors.affiliation: Abteilung Pharmakovigilanz, Bundesinstitut für Arzneimittel und Medizinprodukte, Bonn. b.sachs@bfarm.de
authors.forename: B
authors.initials: B
authors.lastname: Sachs
authors.forename: H F
authors.initials: HF
authors.lastname: Merk
mesh_terms: D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D004342:Drug Hypersensitivity / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'