TEL-AML1 frequency in multi-ethnic Malaysian pediatric acute lymphoblastic leukemia.
Eighty-eight multi-ethnic Malaysian pediatric acute lymphoblastic leukemia (ALL) patients were screened for the TEL-AML1 rearrangement by reverse transcription-polymerase chain reaction (RT-PCR). Fluorescence in situ hybridization (FISH) was used as an independent screen for 30 cases and to confirm RT-PCR positive cases. Seventeen patients, or 19%, were found to be t(12;21) positive. Ethnically the group comprised 12 Malays, 4 Chinese, and 1 Indian. All patients, including 1 with an unusual blast cell morphology who suffered an early relapse and death, were characteristic TEL-AML1 cases in cell count, age, ALL subset classification, and fusion transcript expressed. This study shows that in Malaysia, TEL-AML1 is found in the same distinct ALL subset and at a similar frequency as in other diverse childhood ALL cohorts.
Gill
Harvindar Kaur
HK
Allergy & Immunology Research Centre, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia. gilhk@imr.gov.my
Keoh
Ten Sew
TS
Dhaliwal
Jasbir Singh
JS
Moore
Sarah
S
Kim
Tan Sew
TS
Hassan
Roshida
R
Karim
Faraiza Abdul
FA
Zakaria
Zubaidah
Z
Murad
Shahnaz
S
Mohamed
Mahfuzah
M
Li Ho
Caroline Mei
CM
Ibrahim
Hishamshah
H
Rahman
Eni Juraida Abdul
EJ
D001853:Bone Marrow / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002681:China / Q000208:ethnology; D050676:Core Binding Factor Alpha 2 Subunit; D005006:Ethnicity / Q000235:genetics; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D016130:Immunophenotyping; D007194:India / Q000208:ethnology; D008296:Malaysia; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000097764:ETS Translocation Variant 6 Protein
D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein