Effect of losartan on muscle sympathetic activity and baroreceptor function in systemic hypertension.
Angiotensin II directly stimulates muscle sympathetic nerve activity and facilitates adrenergic sympathetic transmission. The hypotheses that the chronic blockade of angiotensin II receptors (AT(1) type) reduces muscle sympathetic activity and that there is an interaction with baroreceptor function in patients with mild to moderate hypertension were investigated. Muscle sympathetic nerve activity decreased from 51.7 +/- 3.5 to 45.9 +/- 4.2 bursts/min (p = 0.022), and cardiac baroreceptor sensitivity increased from 3.2 +/- 1.3 to 4.9 +/- 1.8 ms/mm Hg (p = 0.007). This study for the first time demonstrates that in hypertensive patients, chronic AT(1) receptor antagonism inhibits muscle sympathetic nerve activity and that baroreceptor function is improved under these conditions.
Béchir
Markus
M
Cardiovascular Center, Cardiology, University Hospital Zürich, Zürich, Switzerland. markus.bechir@ksb.ch <markus.bechir@ksb.ch>
Enseleit
Frank
F
Chenevard
Rémy
R
Lüscher
Thomas F
TF
Noll
Georg
G
D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D019808:Losartan / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000294:innervation* / Q000503:physiopathology; D011311:Pressoreceptors / Q000187:drug effects* / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology
D047228:Angiotensin II Type 1 Receptor Blockers; D019808:Losartan