title: Relationship between plasma and hippocampal lipid peroxidation in obese and hypertensive SHR/NDmcr-cp rats.
abstract: 1. It has been suggested that hypertension, hyperlipidaemia and diabetes participate in the onset and development of dementia. 2. To understand cognitive dysfunction in metabolic syndrome, the relationship between the plasma and the hippocampus regarding fatty acid composition and lipid peroxidation was estimated in genetically hypertensive and obese SHR/NDmcr-cp rats (SHR-cp) aged 7-9 and 18-20 weeks. 3. Levels of total fatty acids and lipid peroxide in the plasma were much higher (by 200-500%) in SHR-cp compared with age-matched control rats (Wistar-Kyoto rats). However, in the hippocampus these levels were not significantly different between the two groups of rats. 4. Levels of hippocampal lipid peroxide in both groups increased significantly with ageing. 5. These results indicate that, in SHR-cp, lipid peroxidation in the hippocampus would not be affected even if plasma levels of fatty acids and lipid peroxide increased markedly, when ageing is not a predicative factor.
authors.affiliation: Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Japan. michio1@med.shimane-u
authors.forename: Michio
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kubota
authors.forename: Naoko
authors.initials: N
authors.lastname: Tanaka
authors.forename: Yu
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Fujii
authors.forename: Satomi
authors.initials: S
authors.lastname: Kagota
authors.forename: Eisuke
authors.initials: E
authors.lastname: Kawakita
authors.forename: Osamu
authors.initials: O
authors.lastname: Shido
authors.forename: Masaru
authors.initials: M
authors.lastname: Kunitomo
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Shinozuka
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D003072:Cognition Disorders / Q000209:etiology; D005227:Fatty Acids / Q000097:blood; D006624:Hippocampus / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D024821:Metabolic Syndrome / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde