title: The chick; a great model system becomes even greater.
abstract: The chick embryo has a long and distinguished history as a major model system in developmental biology and has also contributed major concepts to immunology, genetics, virology, cancer, and cell biology. Now, it has become even more powerful thanks to several new technologies: in vivo electroporation (allowing gain- and loss-of-function in vivo in a time- and space-controlled way), embryonic stem (ES) cells, novel methods for transgenesis, and the completion of the first draft of the sequence of its genome along with many new resources to access this information. In combination with classical techniques such as grafting and lineage tracing, the chicken is now one of the most versatile experimental systems available.
authors.affiliation: Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom. c.stern@ucl.ac.uk
authors.forename: Claudio D
authors.initials: CD
authors.lastname: Stern
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000502:physiology; D002642:Chick Embryo; D002645:Chickens; D015509:Developmental Biology / Q000266:history / Q000639:trends; D005821:Genetic Techniques / Q000639:trends; D016678:Genome; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D007255:Information Services / Q000600:supply & distribution; D023421:Models, Animal