The periarterial space in the lung: its important role in lung edema, transplantation, and microbial or allergic inflammation.
In mammal lungs different compartments for leukocytes can be identified during health and disease, e.g. lung interstitium, bronchoalveolar space, the epithelium and lamina propria of the air-conducting part. A so far neglected compartment is the space around the branches of the pulmonary arteries, characterized by a unique architecture of capillaries running in parallel to the pulmonary artery. This compartment - the periarterial space - is described and its physiological and pathophysiological role reviewed. The periarterial space is infiltrated by different leukocyte subsets during edema formation in the early stages of a lung transplant rejection and, in particular, during inflammatory and allergic reactions. The periarterial compartment seems to be of major relevance in all these situations.
Pabst
R
R
Department of Functional and Applied Anatomy, Medical School of Hannover, Hannover, Germany. Pabst.Reinhard@mh-hannover.de
D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology*; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology*; D007962:Leukocytes / Q000276:immunology; D008168:Lung / Q000098:blood supply* / Q000382:microbiology* / Q000503:physiopathology; D016040:Lung Transplantation / Q000276:immunology*; D011651:Pulmonary Artery / Q000276:immunology; D011654:Pulmonary Edema / Q000209:etiology / Q000503:physiopathology*