"Ins and outs" of seven-transmembrane receptor signalling to ERK.
Extracellular-signal-regulated kinases 1 and 2 (ERK1/2) are important members of the mitogen-activated protein kinase (MAPK) family and have emerged as key effector targets of activation by seven-transmembrane-spanning (G-protein-coupled) receptors (7TMRs). Regulation of ERK by 7TMRs is highly complex and dependent on cell type. Numerous studies have linked specific G protein pathways to ERK activation, but recent evidence suggests that some 7TMR-linked ERK signalling pathways might not be exclusively mediated by G proteins. In addition, the emergence of an "inside-out" model for receptor tyrosine kinase (RTK) "transactivation" by 7TMRs has enhanced our understanding of the ERK signalling system and further underscores the complexity of mitogenic regulation by 7TMRs.
Werry
Tim D
TD
Department of Pharmacology, University of Melbourne, Parkville, Victoria 3010, Australia.
Sexton
Patrick M
PM
Christopoulos
Arthur
A
D000818:Animals; D019390:Arrestins / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D019390:Arrestins; D020928:Mitogen-Activated Protein Kinases; D019204:GTP-Binding Proteins