Suitability of hollow fibre liquid-phase microextraction for the determination of acidic pharmaceuticals in wastewater by liquid chromatography-electrospray tandem mass spectrometry without matrix effects.
The applicability of hollow fibre liquid-phase microextraction (LPME), as an alternative to solid-phase extraction (SPE), for the extraction/enrichment of acidic drugs (e.g. ibuprofen, clofibric acid, bezafibrate, etc.) from water samples prior to the determination by LC-ESI-MS-MS has been evaluated. After LPME method optimisation, it was found that this technique can provide very clean extracts, which do not lead to signal suppression during LC-ESI-MS-MS analysis of the analytes. The limits of quantification (0.5-42 ng/L) are suitable for the analysis of these drugs in wastewater. However repeatability needs to been improved (intra-day R.S.D. = 3.4-32%), which may be expected by automation and the development of commercially available devices and fibres specially prepared for analytical purposes. The method was finally applied to wastewater samples (treated and untreated) and results comparable to SPE were obtained.
Quintana
José Benito
JB
Departamento de Química Analítica, Nutrición e Bromatoloxía, Universidade de Santiago de Compostela, 15782-Santiago de Compostela, Spain. sttito@usc.es
Rodil
Rosario
R
Reemtsma
Thorsten
T
D002853:Chromatography, Liquid / Q000379:methods*; D007220:Industrial Waste; D004364:Pharmaceutical Preparations / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D014874:Water Pollutants, Chemical / Q000032:analysis*
D007220:Industrial Waste; D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical