title: Transfusion associated graft versus host disease.
abstract: Transfusion-associated graft-versus-host disease (TA-GVHD) is a dreaded complication in immunocompromized hosts. The diagnosis is often delayed because of lack of awareness and the non-specific clinical features. More than 90% patients succumb to refractory infections. The only effective preventive measure is administration of irradiated blood products, which must be made available in centers managing immunocompromised patients. We report three cases and discuss pathophysiology and preventive strategies in this communication.
authors.affiliation: Division of Pediatric Hematology-Oncology, Advanced Pediatric Center, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012 India.
authors.forename: Anju
authors.initials: A
authors.lastname: Gupta
authors.forename: Deepak
authors.initials: D
authors.lastname: Bansal
authors.forename: Rashna
authors.initials: R
authors.lastname: Dass
authors.forename: Ashim
authors.initials: A
authors.lastname: Das
mesh_terms: D002648:Child; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D065227:Transfusion Reaction
chemical_list: D008775:Methylprednisolone