Implementing large-scale ENU mutagenesis screens in North America.
A step towards annotating the mouse genome is to use forward genetics in phenotype-driven screens to saturate the genome with mutations. The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening.
Clark
Amander T
AT
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Goldowitz
Daniel
D
Takahashi
Joseph S
JS
Vitaterna
Martha Hotz
MH
Siepka
Sandra M
SM
Peters
Luanne L
LL
Frankel
Wayne N
WN
Carlson
George A
GA
Rossant
Janet
J
Nadeau
Joseph H
JH
Justice
Monica J
MJ
D000818:Animals; D002874:Chromosome Mapping; D004195:Disease Models, Animal; D005038:Ethylnitrosourea; D005260:Female; D008297:Male; D051379:Mice / Q000235:genetics*; D009154:Mutation; D009316:National Institutes of Health (U.S.); D009422:Nervous System Diseases / Q000235:genetics; D010641:Phenotype; D014481:United States
D005038:Ethylnitrosourea