[GnRH antagonists in insemination : can we avoid weekends?].
Twenty five per cent of all intrauterine inseminations are performed on Saturday or Sunday which is much unconvenient for physicians and patients. A prospective study has been conducted to evaluate whether GnRH antagonist could be useful to avoid IUI on Saturday and Sunday. All patients had monitoring on Wednesday (blodd sampling and ultrasonogrphy). The use of GnRH antagonist allowed to avoid many IUI on week-end: only 8% of all IUI had to be performed on Saturday or Sunday. Nevertheless, 63% of the patients had an injection of GnRH antagonist. Moreover, the length of the stimulation is longer with GnRH antagonists and the cumulative gondatropin dose is higher. Pregnancy rates in IUI cycles do not seem to be decreased by the use of GnRH antagonists. More data are needed to conclude on this end point.
Antoine
J M
JM
Service de Gynécologie Obstétrique et Médecine de la Reproduction, Hôpital Tenon, Paris, France.
D000328:Adult; D004334:Drug Administration Schedule; D016903:Drug Monitoring; D004958:Estradiol / Q000097:blood; D005240:Feasibility Studies; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007246:Infertility / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D007315:Insemination, Artificial / Q000379:methods*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; C061018:ganirelix