[Effect of thymosin alpha1 on immunological function and metabolism in peritoneal sepsis rats].
OBJECTIVE
To investigate the effect of thymosin alpha1 on immunological function and protein metabolism in peritoneal sepsis rats.


METHODS
We observed the effect of thymosin alpha1 on T cell subclassification, TNFalpha, IL-6, IL-10, albumin, C-reactive protein (CRP) and mortality in cecal ligation and puncture (CLP) induced septic rats.


RESULTS
Concentration of TNFalpha and IL-6 in CLP induced septic rats increased significantly, and concentration of IL-10 decreased significantly compared to control group. Thymosin alpha1 significantly decreased TNFalpha, IL-6, and significantly raised concentration of plasma IL-10, percent of CD(3), CD(4), and CD(4)/CD(8) in septic group. Thymosin alpha1 reduced degressive degree of albumin. Concentration of CRP increased in both septic groups, but was less prominently in thymosin alpha1 treated group. Thymosin alpha1 reduced cumulate 7-day mortality.


CONCLUSIONS
Thymosin alpha1 can improve immunological function, inflammation condition and protein metabolism.
Jiang
Jun
J
Department of General Surgery, Nanjing General Hospital of People's Liberation Army, Nanjing 210002, China.
Li
Ning
N
Li
Jie-Shou
JS
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D004195:Disease Models, Animal; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D010538:Peritonitis / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018805:Sepsis / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000276:Adjuvants, Immunologic; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D013947:Thymosin; D002097:C-Reactive Protein; D000077596:Thymalfasin