Long-term antibody response and immunologic memory in children immunized with hepatitis B vaccine at birth.
Four hundred and fifty three healthy children immunized with a course of hepatitis B vaccine beginning at birth were tested at 10-11 years of age for persistence of anti-hepatitis B-S antigen antibody (anti-HBs); and responses of children without protective antibody to different doses of hepatitis B vaccine booster were evaluated. Although nearly 42% of them were not seroprotected, but most of boosted subjects (87.3%) retained robust immunologic memory and rapidly retained a protective anti-HBs antibody titer of at least 10 IU/L after booster vaccination.
Saffar
M J
MJ
Pediatric Infectious Diseases Ward, Department of Pediatrics. Mazandaran Medical Sciences University, Boalisina Hospital, Pasdaran Boulevard, Sari- Iran. saffar@softhome.net
Rezai
M S
MS
D000917:Antibody Formation; D002648:Child; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000627:therapeutic use*; D006801:Humans; D007117:Immunization, Secondary; D007156:Immunologic Memory; D008297:Male; D013997:Time Factors
D017325:Hepatitis B Vaccines