title: The polymorphism of platelet membrane integrin alpha2beta1 (alpha2807TT) is associated with premature onset of fetal loss.
abstract: Inherited thrombophilia could increase susceptibility to adverse pregnancy outcomes such as fetal loss. We determined the G1691A mutation of the factorV gene (FVL), the G20210A mutation of the prothrombin gene, the C677T polymorphism of the methylenetetrahydrofolate-reductase (MTHFR) gene, the HPA-1 polymorphism of the beta3 subunit of the platelet integrin alphaIIbbeta3 and the C807T polymorphism of the alpha2 subunit of integrin alpha2beta1 in 104 women with fetal loss and 277 normal women. In a subgroup analysis of women with recurrent early fetal loss (n=34), the prevalence of the genetic markers did not differ significantly between the women with early fetal loss and the normal women. However, in this subgroup of patients the onset of fetal loss was significantly earlier in women with the alpha2807TT genotype (7.1 +/- 1.9 vs. 8.8 +/- 1.5 weeks, p=0.001). No such significant difference was observed in carriers of the other genetic markers. In the subgroup analysis of women with late fetal loss (n=70), only the prevalence of heterozygous FVL was significantly associated with late fetal loss (odds ratio 3.2, p=0.002). There was no significant association of any genetic risk factor with premature fetal loss in the subgroup analysis of women with at least one late miscarriage. This study demonstrates a significant association of the alpha2807TT genotype of the platelet membrane integrin alpha2beta1 with premature onset of early fetal loss. It appears that this risk factor does not induce the pathomechanism, but modulates the course of fetal loss. Furthermore, our study confirms the association of FVL with late fetal loss.
authors.affiliation: Department of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Düsseldorf, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Gerhardt
authors.forename: Rüdiger E
authors.initials: RE
authors.lastname: Scharf
authors.forename: Barbara
authors.initials: B
authors.lastname: Mikat-Drozdzynski
authors.forename: Jan S
authors.initials: JS
authors.lastname: Krüssel
authors.forename: Hans G
authors.initials: HG
authors.lastname: Bender
authors.forename: Rainer B
authors.initials: RB
authors.lastname: Zotz
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005165:Factor V; D005260:Female; D005838:Genotype; D006801:Humans; D038982:Integrin alpha2beta1 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D019851:Thrombophilia / Q000235:genetics
chemical_list: D038982:Integrin alpha2beta1; C095381:factor V Leiden; D005165:Factor V