title: Propofol total intravenous anesthesia for MRI in children.
abstract: BACKGROUND
  The aim of this study was to assess clinical signs of airway patency, airway intervention requirements and adverse events in 100 children receiving propofol total intravenous anesthesia for magnetic resonance imaging, with spontaneous ventilation and oxygenation via nasal prongs.
  
  
  METHODS
  Airway patency was clinically assessed and stepwise interventions were performed until a satisfactory airway was achieved. Propofol requirements, vital signs, procedure times and adverse events were also recorded.
  
  
  RESULTS
  Ninety-three per cent of children had no signs of airway obstruction when positioned with a shoulder roll only, two required a chin lift, four required an oral airway and one required lateral positioning. The mean propofol induction dose was 3.9 mg.kg(-1) (range 1.8-6.4 mg.kg(-1)). The mean propofol infusion rate was 193 microg.kg(-1).min(-1) (range 150-250 microg.kg(-1).min(-1)). The initial and final mean respiratory rates were 26 and 23 b.min(-1) (P < 0.05). Movement was more likely at lower infusion rates (mean 175 microg.kg(-1).min(-1)). There were no respiratory or cardiovascular complications (calculated risk: 95% CI = 0-3%). The mean time from end of scan to discharge home was 44 min.
  
  
  CONCLUSIONS
  This study demonstrates good preservation of upper airway patency and rapid recovery using general anesthetic doses of propofol in children.
authors.affiliation: Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton, Alberta T6G 2B7, Canada. ausher@ualberta.ca
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Usher
authors.forename: Ramona A
authors.initials: RA
authors.lastname: Kearney
authors.forename: Ban C H
authors.initials: BC
authors.lastname: Tsui
mesh_terms: D000293:Adolescent; D000771:Anesthesia, Intravenous / Q000009:adverse effects; D018686:Anesthetics, Intravenous / Q000009:adverse effects; D019296:Capnography; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010092:Oximetry; D015742:Propofol / Q000009:adverse effects; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D015742:Propofol