[The effects of gender on heart rate adjustment of ST segment depression for identifying coronary arteriosclerosis disease].
OBJECTIVE
To assess the effects of gender on heart rate adjustment of ST segment depression (ST/HR) for identifying coronary arteriosclerotic disease.


METHODS
One hundred and seventy three patients with suspected coronary disease (CAD) were referred for a routine treadmill exercise electrocardiogram and subsequently they underwent selective coronary angiography within 3 weeks. The magnitude of ST segment depression, ST/HR slope and calculated ST/HR index are performed by a computerized ECG system; exercise was performed according to the cornell protocol. CAD was defined by coronary angiography. We divided the patients into two groups by gender.


RESULTS
Sensitivity and specificity for identifying CAD with ST/HR slope and ST/HR index were all significantly greater than that of standard electrocardiographic test criteria (P <0.05). Compared with standard criteria, the sensitivity for identifying CAD of ST/HR slope and ST/HR index increased 23% and 16% in men, 50% and 42% in women respectively; all difference were statistically significant (P <0.05). The specificity for identifying CAD with ST/HR slope and ST/HR index increased 58% and 50% in women, with no increase in men.


CONCLUSIONS
It is suggested that sensitivity and specificity for identifying CAD with ST/HR slope and ST/HR index were all significantly higher than those with standard electrocardiographic test criteria in selected women patients. Sensitivity were significantly increased in selected men patients, with no significant change in specificity.
Shi
Xu-bo
XB
Heart Center, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China.
Hu
Da-yi
DY
Zhao
Ming-zhong
MZ
Wang
Hong-yu
HY
Guo
Dan-jie
DJ
Li
Da-gong
DG
D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D012737:Sex Factors