SDF-1 tells stem cells to mind their P's and Z's.
Stromal cell-derived factor-1 (SDF-1) is a chemokine with unique functions, including a role in the trafficking of primitive blood precursor cells. A better understanding at a molecular level of how the binding of SDF-1 to its cell surface receptor, CXCR4, elicits specific biological responses in these cells has now been achieved through the identification of PKC-zeta activation as a common downstream signal. This finding suggests that treatment of a variety of clinical conditions might benefit from the targeting of PKC-zeta.
Eaves
Connie J
CJ
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada. ceaves@bccrc.ca
D000818:Animals; D002465:Cell Movement; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D011493:Protein Kinase C / Q000378:metabolism*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*; D000099221:Protein Kinase C zeta
D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D011493:Protein Kinase C; D000099221:Protein Kinase C zeta; C515255:CXCL12 protein, human