Effects of clomipramine on cats presented for urine marking.
Twenty-five cats exhibiting at least four episodes of vertical urine marking per week were assessed. Following a medical workup, a 4-week clomipramine trial was instituted, using a mean dose of 0.54 mg/kg per os q 24 hours. No concurrent behavioral or environmental modifications were applied. There was a statistically significant (P<0.0001) decrease in urine spraying when the cats were on clomipramine, with 20 of 25 cats having a > or =75% reduction in spraying within 4 weeks. Side effects were mild. Twenty cats were followed for an additional 5 months. Fifteen cats required medication to control the spraying, often at a reduced dose.
Landsberg
Gary M
GM
Doncaster Animal Clinic, Thornhill, Ontario, Canada.
Wilson
Andrea L
AL
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D002997:Clomipramine / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D008297:Male; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014555:Urination Disorders / Q000188:drug therapy / Q000662:veterinary*
D002997:Clomipramine; D017367:Selective Serotonin Reuptake Inhibitors