Chemical modifications of bile acids under high-intensity ultrasound or microwave irradiation.
High-intensity ultrasound (HIU) and microwave (MW) irradiation, having emerged as effective promoters of organic reactions, were exploited for the synthesis of bile acids derivatives. Esterification, amidation, hydrolysis, oxidation, and reduction were investigated. Compared to conventional methods, both techniques proved much more efficient, increasing product yields and dramatically cutting down reaction times. Scaled-up studies are now under way.
Cravotto
Giancarlo
G
Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via Giuria 9, 10125 Torino, Italy. giancarlo.cravotto@unto.it
Boffa
Luisa
L
Turello
Marta
M
Parenti
Massimo
M
Barge
Alessandro
A
D001647:Bile Acids and Salts / Q000737:chemistry* / Q000528:radiation effects*; D008872:Microwaves; D008968:Molecular Conformation; D014465:Ultrasonics
D001647:Bile Acids and Salts