Polyglandular autoimmune syndrome type III accompanied by common variable immunodeficiency.
We identified polyglandular autoimmune (PGA) syndrome type III in a 24-year-old nurse with common variable immunodeficiency (CVID). An immune-mediated disorder, membranoproliferative glomerulonephritis, was diagnosed when she was 15 years old. Clinical examination and laboratory findings revealed a PGA syndrome due to the presence of hypergonadotropic hypogonadism, insufficient growth hormone response and thyroid autoimmunity. The patient had neither adrenal disease nor hypoparathyroidism. Therefore we concluded that this patient has PGA syndrome type III. This is an interesting case, because we could not find any previous report of such coexistence between PGA type III and CVID in a Medline search. Coexistence of these two entities may be a result of autoimmunity and the association of both conditions with human leukocyte antigen.
Bahceci
M
M
Department of Endocrinology and Metabolism, Dicle University, School of Medicine, Diyarbakir, Turkey.
Tuzcu
A
A
Pasa
S
S
Ayyildiz
O
O
Tuzcu
S
S
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D015519:Bone Density; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis / Q000276:immunology; D019382:Human Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007006:Hypogonadism / Q000276:immunology; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D013961:Thyroid Gland / Q000276:immunology
D001323:Autoantibodies; D004966:Estrogens, Conjugated (USP); D019382:Human Growth Hormone; D017258:Medroxyprogesterone Acetate