Unexpected effects of inhaled fluticasone in an HIV patient with asthma.
International guidelines recommend prescription of inhaled corticosteroids to improve asthma control. Chronic secondary adrenal suppression due to inhaled corticosteroids has been described. We report a case of acute adrenal suppression due to drug interaction between Fluticasone and antiretroviral therapy in a HIV patient. Seeing an increased prevalence of hyperresponsiveness among HIV-infected men, we conclude that coprescription of Fluticasone and highly active antiretroviral therapy must be carefully controlled.
Nocent
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Service des Maladies Respiratoires, Hôpital Haut Lévèque, Pessac Cedex, France. cejnaini@9online.fr
Raherison
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C
Dupon
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M
Taytard
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A
D000208:Acute Disease; D000280:Administration, Inhalation; D000309:Adrenal Insufficiency / Q000139:chemically induced*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000730:Androstadienes / Q000009:adverse effects* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D000068298:Fluticasone; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male
D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D000324:Adrenocorticotropic Hormone; D000068298:Fluticasone; D006854:Hydrocortisone