[The carcinogenesis of human cytomegalovirus to mouse cervix].
We plugged the gelfoam impregnated with virus stock solution into mouse cervix with ophthalmic forceps. Mice of Kun-Ming strain were infected with UV-inactivated HCMV (human cytomegalovirus). After 31 weeks, cervical carcinomas were induced in 15% of the infected mice. In another group, infected with UV-inactivated HCMV adding croton oil, the carcinogenesis was 18.8%, but incontrol group, it was 0%. HCMV IE (immediate early) antigen in 12 cancer tissues of UV-inactivated HCMV treated group were all positive, and HCMV IE antibody geometrical average titre in mouse serum of the same group was 1:167.2, but the same two parameters in control group were both negative. The ANAE positive rate of lymphocytes in mouse peripheral blood of UV-inactivated HCMV treated group was 38.9 +/- 6.8%, and of control group was 67.8 +/- 8.0%.
Wang
Z
Z
Department of Oncogenic Virus Research Institute, Hubei Medical University, Wuhan 430071.
Sun
Y
Y
Lu
D
D
Deng
P
P
D000818:Animals; D002277:Carcinoma / Q000209:etiology / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology* / Q000821:virology*; D003587:Cytomegalovirus / Q000472:pathogenicity*; D003586:Cytomegalovirus Infections / Q000150:complications*; D005260:Female; D006801:Humans; D051379:Mice; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000821:virology*