[The effect of hyaluronic acid external film on rats wound healing].
OBJECTIVE
To observe the effect of an external film of hyaluronic acid (HA) on the rats wound healing.


METHODS
Forty-eight SD rats were randomly separated into eight groups of 6 rats each. Bilateral dorsal cuts were performed on each rat, left wound was used as the experiment with HA external film and right wound was used as the control only with normal saline. The process of healing was observed histologically following 1st, 3rd, 5th, 7th, 9th, 14th, 21st, and 28th days postoperatively.


RESULTS
Inflammation was lighter and epidermal healing was faster in the experimental group than those in the control. The fibroblasts degenerated and the collagen fiber changed to slim and loose bunches in the experimental group.


CONCLUSIONS
The results indicated that HA external film could have powerful infiltrating activity at the early stage of wound healing, it could accelerate the healing of epidermis and delay the formation of keratinization layer.
Ren
Gui-yun
GY
Department of Oral and Maxillofacial Surgery, School of Stomatology, Hebei Medical University, Shijiazhuang 050017, China.
Dong
Fu-sheng
FS
Wang
Jie
J
Shi
Pei-kai
PK
D000818:Animals; D003094:Collagen / Q000378:metabolism; D004333:Drug Administration Routes; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
D006820:Hyaluronic Acid; D003094:Collagen