Non-nucleoside structures retain full anti-HCMV potency of the dideoxy furanopyrimidine family.
We have recently reported that 2',3'dideoxy analogues of our exquisitely potent anti-VZV furanopyrimidine deoxynucleosides are shifted to selective anti-HCMV agents. We now find that the fully deoxygenated 2',3',5'-trideoxy analogue is fully antivirally active. This is taken as proof that these agents act by a novel non-nucleoside mechanism of action.
Bidet
Olivier
O
Welsh School of Pharmacy, Cardiff University, Cardiff, UK. bideto@cardiff.ac.uk
McGuigan
Christopher
C
Snoeck
Robert
R
Andrei
Graciela
G
De Clercq
Erik
E
Balzarini
Jan
J
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects*; D015224:Dideoxynucleosides / Q000737:chemistry / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry*; D006801:Humans; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D005663:Furans; D011741:Pyrimidine Nucleosides