title: Dermal fibrosis and cutaneous necrosis after recombinant interferon-beta1a injection in a multiple sclerosis patient.
abstract: The most commonly reported side-effects of recombinant interferon-beta1a and 1b include local inflammatory injection site reactions, headache, fever, myalgia and a flu-like syndrome. In this case report, we describe the occurrence of cutaneous necrosis and dermal fibrosis following intramuscular interferon-beta1a injections in a multiple sclerosis patient.
authors.affiliation: Gazi University, Faculty of Medicine, Dermatology Department, 06100 Besevler, Ankara, Turkey.
authors.forename: M G
authors.initials: MG
authors.lastname: Ozden
authors.forename: A
authors.initials: A
authors.lastname: Erel
authors.forename: O
authors.initials: O
authors.lastname: Erdem
authors.forename: M O
authors.initials: MO
authors.lastname: Oztas
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis / Q000209:etiology*; D006801:Humans; D007267:Injections / Q000009:adverse effects; D016899:Interferon-beta / Q000008:administration & dosage / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000188:drug therapy*; D009336:Necrosis / Q000209:etiology; D012883:Skin Ulcer / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology
chemical_list: D016899:Interferon-beta