Antidiabetic effects of extracts from Psidium guajava.
During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Lepr(db)/Lepr(db) mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10mg/kg in both 1- and 3-month-old Lepr(db)/Lepr(db) mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated Lepr(db)/Lepr(db) mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B.
Oh
Won Keun
WK
Korea Research Institute of Bioscience and Biotechnology (KRIBB), P.O. Box 115, Yusong, Daejeon 305-600, South Korea.
Lee
Chul Ho
CH
Lee
Myung Sun
MS
Bae
Eun Young
EY
Sohn
Cheon Bae
CB
Oh
Hyuncheol
H
Kim
Bo Yeon
BY
Ahn
Jong Seog
JS
D000367:Age Factors; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D005260:Female; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D031647:Psidium
D007004:Hypoglycemic Agents; D010936:Plant Extracts