A new family of "H3L-like" histone genes.
The H3L histone variant gene in Paracentrotus lividus (sea urchin) shows almost all typical features of the replication-dependent histone genes, but it codes for the H3.3 histone protein with the S.//. A.IG amino acid motif, which is typical of the variants synthesized in a replication-independent manner. "H3L-like" histone genes have been found in several unrelated organisms. These genes are intronless and encode for the typical H3.3 histone proteins. The newly described family of H3L-like variants, nearly ubiquitous within the animal kingdom, could represent the common ancestor of H3 and H3.3 histone genes.
Mancini
P
P
Department of Genetics, General and Molecular Biology, University of Naples Federico II, Via Mezzocannone 8, 80134 Naples, Italy.
Pulcrano
G
G
Piscopo
M
M
Aniello
F
F
Branno
M
M
Fucci
L
L
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D014644:Genetic Variation; D016678:Genome; D006657:Histones / Q000235:genetics*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D021141:Nucleic Acid Amplification Techniques; D016415:Sequence Alignment; D017421:Sequence Analysis; D014158:Transcription, Genetic
D006657:Histones