title: Implementing large-scale ENU mutagenesis screens in North America.
abstract: A step towards annotating the mouse genome is to use forward genetics in phenotype-driven screens to saturate the genome with mutations. The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Amander T
authors.initials: AT
authors.lastname: Clark
authors.forename: Daniel
authors.initials: D
authors.lastname: Goldowitz
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Takahashi
authors.forename: Martha Hotz
authors.initials: MH
authors.lastname: Vitaterna
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Siepka
authors.forename: Luanne L
authors.initials: LL
authors.lastname: Peters
authors.forename: Wayne N
authors.initials: WN
authors.lastname: Frankel
authors.forename: George A
authors.initials: GA
authors.lastname: Carlson
authors.forename: Janet
authors.initials: J
authors.lastname: Rossant
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Nadeau
authors.forename: Monica J
authors.initials: MJ
authors.lastname: Justice
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004195:Disease Models, Animal; D005038:Ethylnitrosourea; D005260:Female; D008297:Male; D051379:Mice / Q000235:genetics*; D009154:Mutation; D009316:National Institutes of Health (U.S.); D009422:Nervous System Diseases / Q000235:genetics; D010641:Phenotype; D014481:United States
chemical_list: D005038:Ethylnitrosourea