title: Radiosensitivity of peripheral blood lymphocytes obtained from patients with cancers of the breast, head and neck or cervix as determined with a micronucleus assay.
abstract: The in vitro radiation sensitivities of peripheral blood lymphocytes obtained from 48 normal females and 168 female cancer patients were measured with the cytokinesis-blocking micronucleus assay. Cancer patients group had significantly higher mean baseline micronucleus frequency than normal healthy controls. Breast cancer patients were more radiosensitive than normal individuals. Cervical cancer cases were less radiation sensitive than normal subjects. The relative lack of radiation sensitivity in cervical-cancer cases could be due to modification of the radiosensitivity of patients' immune-responsible cells by human papillomaviruses infection. Normal individuals and cancer patients were classified according to their radiation sensitivity which was evaluated with the radiation-induced micronucleus frequencies. Such a classification will be an important initial step to characterize the radiosensitive, radioresistant, or cancer-prone individuals using specific SNP typing.
authors.affiliation: Frontier Research Center, National Institute of Radiological Sciences (NIRS), Chiba, Japan. s_ban@nirs.go.jp
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Ban
authors.forename: Chika
authors.initials: C
authors.lastname: Konomi
authors.forename: Mayumi
authors.initials: M
authors.lastname: Iwakawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamada
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ohno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsuji
authors.forename: Syuhei
authors.initials: S
authors.lastname: Noda
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Matui
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Harada
authors.forename: John B
authors.initials: JB
authors.lastname: Cologne
authors.forename: Takashi
authors.initials: T
authors.lastname: Imai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy*; D016022:Case-Control Studies; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D015162:Micronucleus Tests / Q000379:methods*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011836:Radiation Tolerance; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000188:drug therapy*