Stille cross-couplings of unactivated secondary alkyl halides using monoorganotin reagents.
The first catalyst that achieves Stille cross-couplings of secondary (as well as primary) alkyl halides has been developed. The method employs easily handled and inexpensive catalyst components (NiCl2 and 2,2'-bipyridine) and, through the use of monoorganotin reagents, avoids the formation of toxic and difficult-to-remove triorganotin side products.
Powell
David A
DA
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Maki
Toshihide
T
Fu
Gregory C
GC
D002384:Catalysis; D006838:Hydrocarbons / Q000138:chemical synthesis*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D014001:Tin / Q000737:chemistry*
D006838:Hydrocarbons; D006846:Hydrocarbons, Halogenated; D009942:Organometallic Compounds; D014001:Tin