Amphiphilic alpha-helical antimicrobial peptides and their structure/function relationships.
To facilitate microbial membrane invasion, amphiphilic alpha-helical antimicrobial peptides (alpha-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the alpha-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.
Dennison
Sarah R
SR
Department of Forensic and Investigative Science, University of Central Lancashire, Preston, UK.
Wallace
James
J
Harris
Frederick
F
Phoenix
David A
DA
D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000378:metabolism; D002462:Cell Membrane / Q000737:chemistry; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000737:chemistry
D000596:Amino Acids; D023181:Antimicrobial Cationic Peptides; D013501:Surface-Active Agents