Pardon me--no access without ubiquitin.
Spatial separation of ubiquitin conjugation pathways contributes to target-specific ubiquitination. Recently, Plafker et al. reported that importin 11-dependent nuclear import of the ubiquitin-conjugating enzyme UbcM2 occurs only if the latter is charged with ubiquitin. This interesting finding describes a link between nuclear transport pathways and ubiquitin and reveals a novel mechanism for localizing components of the ubiquitin system within the cell.
Sommer
Thomas
T
Max-Delbrück Center for Molecular Medicine, Robert-Rossle Str. 10, D-13092 Berlin, Germany.
Jarosch
Ernst
E
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000818:Animals; D028884:Karyopherins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D025801:Ubiquitin / Q000502:physiology*; D044763:Ubiquitin-Conjugating Enzymes / Q000378:metabolism
D028884:Karyopherins; D025801:Ubiquitin; D044763:Ubiquitin-Conjugating Enzymes