AMPA receptor antagonists as potential anticonvulsant drugs.
Over the last years alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPARs) have been intensively studied owing to their crucial role in physiological and pathological processes. Efforts targeting AMPAR have been focused on identification of ligands as potential therapeutic agents useful in the prevention and treatment of a variety of neurological and non-neurological diseases. In particular, extensive work was addressed to the discovery of selective antagonists some of which proved to be potent anticonvulsant agents.
De Sarro
Giovambattista
G
Department of Experimental and Clinical Medicine, University of Catanzaro, Italy.
Gitto
Rosaria
R
Russo
Emilio
E
Ibbadu
Guido Ferreri
GF
Barreca
Maria Letizia
ML
De Luca
Laura
L
Chimirri
Alba
A
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D001667:Binding, Competitive / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*
D000927:Anticonvulsants; D018091:Receptors, AMPA