title: Antioxidant phenolic compounds from rhizomes of Polygonum paleaceum.
abstract: Polygonum paleaceum Wall. ex Hook. f. is a small herb in Polygonaceae family. In southwest of China, the rhizomes of this plant were used as folk drug for the treatment of chronic gastritis, duodenal ulcers, dysentery, wound, pain, hemorrhage and irregular menstruation. The crude aqueous acetone extract exhibited high antioxidant activity (SC(50) = 16.72 micro/ml) in 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. With bioactivity-guided fractionations, 14 antioxidant phenolic compounds 1-14 were obtained from the air-dried rhizomes of this plant. Of them, compound 1, a new phenol named paleaceolactoside, was determined to be 3,5-dihydroxyl hexanoic acid 1,5-lactone 3-(6'-o-galloyl)-o-beta-D-glucopyranoside by detailed spectroscopic analysis. The radical-scavenging activity of all the isolated compounds was also described.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
authors.forename: Kai-Jin
authors.initials: KJ
authors.lastname: Wang
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Chong-Ren
authors.initials: CR
authors.lastname: Yang
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification; D005609:Free Radicals / Q000737:chemistry; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D028502:Polygonum / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005609:Free Radicals; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl