title: Magnetic resonance relaxometry in monozygotic twins discordant and concordant for schizophrenia.
abstract: T1 and T2 relaxation times were examined in four pairs of monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high genetic loading for the illness and five healthy control MZ twin pairs. Patients with schizophrenia (n = 11) showed significant prolongation in T1 relaxation times in the globus pallidus (GP) bilaterally (P < 0.005, Bonferroni corrected) when compared to 14 healthy MZ twins.
authors.affiliation: Psychiatric Center Prague, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic. spaniel@pcp.lf3.cuni.cz
authors.forename: Filip
authors.initials: F
authors.lastname: Spaniel
authors.forename: Vit
authors.initials: V
authors.lastname: Herynek
authors.forename: Tomas
authors.initials: T
authors.lastname: Hajek
authors.forename: Monika
authors.initials: M
authors.lastname: Dezortova
authors.forename: Jiri
authors.initials: J
authors.lastname: Horacek
authors.forename: Milan
authors.initials: M
authors.lastname: Hajek
authors.forename: Jiri
authors.initials: J
authors.lastname: Kozeny
authors.forename: Colleen
authors.initials: C
authors.lastname: Dockery
authors.forename: Cyril
authors.initials: C
authors.lastname: Höschl
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D004200:Diseases in Twins / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D013997:Time Factors; D014430:Twins, Monozygotic
chemical_list: D014150:Antipsychotic Agents