[New acellular pertussis vaccine, containing glucosaminylmuramyldipeptide].
As shown in this work, the synthetic immunomodulator glucosaminylmuramyldipeptide (GMDP) can be included into acellular pertussis vaccine (APV). The optimal doses of GMDP, ranging from 0.001 to 0.0001 microg, have been found. These doses enhance the protective activity of APV, especially its low-active doses. GMDP decrease the manifestations of toxic, anaphylactogenic and pyrogenic properties of APV, which may lead to the decrease of the antigenic load of APV on the body of the vaccines and thus to lessening the side-effects of vaccination. GMDP has been shown to considerably increase, in comparison with common pertussis vaccine and APV, the percentage of phagocytizing leukocytes by day 14. The immunization of mice with APV with and without GMDP in doses of 0.01 and 0.001 microg leads to a change in T-lymphocyte/B-lymphocyte ratio in the population of spleen lymphocytes.
Semenov
B F
BF
Zakharova
N S
NS
Britsina
M V
MV
Mertsalova
N U
NU
Ozeretskovskaia
M N
MN
Valiakina
T I
TI
Komaleva
R L
RL
Andronova
T M
TM
Nesmeianov
V A
VA
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000276:immunology; D000818:Animals; D021461:Animals, Outbred Strains; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D005260:Female; D005334:Fever / Q000139:chemically induced; D007114:Immunization; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000276:immunology; D007274:Injections, Intraperitoneal; D007962:Leukocytes / Q000276:immunology; D018655:Lymphocyte Count; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000009:adverse effects; D010587:Phagocytosis; D013154:Spleen / Q000276:immunology; D022282:Vaccines, Acellular / Q000008:administration & dosage; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control*
D007155:Immunologic Factors; D010567:Pertussis Vaccine; D022282:Vaccines, Acellular; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C023868:N-acetyl-beta-glucosaminyl-N-acetylmuramyl-alanylisoglutamine