The role of electron microscopy in neuropathology.
The electron microscope has been an essential instrument for elucidating the morphology of cells and tissue. Fine structural investigation of nervous tissue has disclosed numerous new findings, which were once invisible. In this communication I present my personal perspective on the role of electron microscopy in neuropathology through the presentation of selected electron microscopic projects engaged in our institution. These include brain edema, structural analysis of the myelin in the central nervous system, endodermal cysts in the central nervous system, aberrant synaptic development, toxoplasmosis in AIDS, and Hirano bodies.
Hirano
Asao
A
Division of Neuropathology, Department of Pathology, Montefiore Medical Center, Bronx, NY, 10467-2094, USA. ahirano@montefiore.org
D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology / Q000821:virology; D001929:Brain Edema / Q000473:pathology; D002490:Central Nervous System / Q000648:ultrastructure*; D006652:Histological Techniques / Q000379:methods; D006801:Humans; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000473:pathology / Q000648:ultrastructure; D009422:Nervous System Diseases / Q000473:pathology*; D016874:Neurofibrillary Tangles / Q000473:pathology / Q000648:ultrastructure; D013569:Synapses / Q000473:pathology / Q000648:ultrastructure; D014123:Toxoplasmosis / Q000473:pathology