The formation of carbon monoxide during peroxidation of microsomal lipids.
The evolution of carbon monoxide during lipid peroxidation has been demonstrated in microsomal membranes. The formation of carbon monoxide was dependent on the peroxidation process, but independent of the initiators (NADPH-ADP x Fe(+3) or Ascorbate-Fe(+3)) used. Contrary to published results, the carbon monoxide does not result from heme catabolism. Carbon monoxide was generated during the peroxidation of isolated phospholipids, indicating that carbon monoxide may form directly during the peroxidative degradation of unsaturated fatty acids.
Wolff
D G
DG
Department of Pharmacology, University of Southern California, School of Medicine, Los Angeles, California 90033, USA.
D000818:Animals; D002248:Carbon Monoxide / Q000378:metabolism*; D006418:Heme / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D013057:Spectrum Analysis
D006418:Heme; D002248:Carbon Monoxide