Imaging of macrophage-related lung diseases.
Macrophage-related pulmonary diseases are a heterogeneous group of disorders characterized by macrophage accumulation, activation or dysfunction. These conditions include smoking-related interstitial lung diseases, metabolic disorders such as Niemann-Pick or Gaucher disease, and rare primary lung tumors. High-resolution computed tomography abnormalities include pulmonary ground-glass opacification secondary to infiltration by macrophages, centrilobular nodules or interlobular septal thickening reflecting peribronchiolar or septal macrophage accumulation, respectively, emphysema caused by macrophage dysfunction, and honeycombing following macrophage-related lung matrix remodeling.
Marten
Katharina
K
Department of Radiology, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK.
Hansell
David M
DM
D002196:Capillaries; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D016676:Macrophages, Alveolar; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012907:Smoking / Q000473:pathology