[The diagnostic ability of Heidelberg retina tomography to detect glaucomatous optic neuropathy in Chinese].
OBJECTIVE
To evaluate the ability of Heidelberg retina tomography (HRT) in the diagnosis of primary open angle glaucoma (POAG).


METHODS
The topography of optic nerve head of 116 normal eyes and 99 eyes with POAG were examined using HRT. The differences of the optic disc parameters between two groups were compared. The topographic parameters of the optic nerve head were undergone stepwised discriminant analysis and the discriminant function was established. The sensitive diagnostic parameters of POAG were screened.


RESULTS
The topographic parameters of optic nerve head, including disc area (DA), cup area (CA), cup/disc area ratio (C/DAR), rim area (RA), height variation contour (HVC), cup volume (CV), rim volume (RV), mean cup depth (MCD), maximum cup depth (MxCD), cup shape measure (CSM), mean retinal nerve fiber layer thickness (mRNFLT), retinal nerve fiber layer cross section area (RNFLA), showed significant (P < 0.001) difference between normal subjects and patients with POAG. The sensitive diagnostic parameters of POAG were C/DAR, RA, CSM, CV, MCD. The discriminant function was Y = -2.083-4.833 x C/DAR-20.379 x CSM + 2.035 x RA + 3.955 x CV-3.701 x MxCD. The sensitivity, specificity and diagnostic accuracy were 81.8%, 86.2% and 84.2%, respectively, which were comparable to the automatic analysis program of HRT.


CONCLUSIONS
The topographic parameters of optic nerve head in patients with POAG showed significant differences from that in normal people. The power of discriminant function established based on our data was comparable to the HRT automatic analysis program. Our results indicate that HRT automatic analysis program is applicable to Chinese.
Liu
Xing
X
Zhongshan Ophthalmic Center, Zhongshan University, Guangzhou 510060, China. ykoct@gzsums.edu.cn
Liang
Yuan-Bo
YB
Ling
Yun-Lan
YL
Huang
Jing-Jing
JJ
Zheng
Xiao-Ping
XP
D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D002681:China; D003941:Diagnostic Techniques, Ophthalmological / Q000592:standards; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology; D012016:Reference Values; D014054:Tomography / Q000592:standards*