Efficacy of boric-complexed zinc and acetic-complexed zinc otic preparations for canine yeast otitis externa.
The purpose of this 2-week, double-blinded, controlled clinical trial was to evaluate the efficacy of topical amino acid-complexed zinc gluconate formulated with boric acid (ZGB) or acetic acid (ZGA) versus a topical placebo in the treatment of yeast otitis externa in dogs. Included in the study were dogs with otitis externa and a cytopathological finding of yeast organisms in the affected ear. Ears were treated with the placebo, ZGA, or ZGB medications. Yeast counts as well as clinical appearance of the ears were monitored. Results revealed that ZGB significantly reduced the number of yeast organisms in cases of otitis externa.
Mendelsohn
Colleen L
CL
Animal Dermatology Clinics, Tustin, California 92780, USA.
Griffin
Craig E
CE
Rosenkrantz
Wayne S
WS
Brown
Larry D
LD
Boord
Mona J
MJ
D019342:Acetic Acid / Q000627:therapeutic use; D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D001888:Boric Acids / Q000627:therapeutic use; D015169:Colony Count, Microbial / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy* / Q000382:microbiology; D004285:Dogs; D004311:Double-Blind Method; D005942:Gluconates / Q000627:therapeutic use*; D010032:Otitis Externa / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D016896:Treatment Outcome; D015003:Yeasts / Q000187:drug effects* / Q000254:growth & development
D001888:Boric Acids; D005942:Gluconates; D019342:Acetic Acid; C030691:gluconic acid