title: Benign symmetric lipomatosis in a 73-year-old man: a case report with a brief review of the literature.
abstract: Benign symmetric lipomatosis (BSL) is a rare disease which is characterized by symmetric diffuse deposition of mature fat tissue and considered to originate in brown fat. A case of benign symmetric lipomatosis in a 73-year old man is presented. He has been treated for alcoholic abuse in mental hospitals several times and referred to our hospital for evaluation and treatment of the subcutaneous tumor in the neck, bilateral supraclavicular areas, bilateral upper arms, anterior chest wall, back, and the abdomen. Resected tumors had ill-defined margin and smooth surface. Histologically, the tumor was composed of diffuse proliferation of mature fat tissues, focal myxoid change and spindle cell proliferation. A histopathological diagnosis of lipomatosis with focal spindle cell proliferation was made. Although several hypotheses of this disease have been postulated, the present case suggested that the etiology of BSL is closely related with alcoholic abuse-induced metabolic disorder and deteriorated function of adipocytes due to specific location of tumor.
authors.affiliation: Surgery Section, Nanbu Tokushukai Hospital, Okinawa 901-0493.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Kise
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Shimoji
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Toda
authors.forename: Masaya
authors.initials: M
authors.lastname: Kiyuna
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwasaki
mesh_terms: D017667:Adipocytes / Q000473:pathology; D000368:Aged; D000437:Alcoholism / Q000150:complications; D006801:Humans; D008069:Lipomatosis, Multiple Symmetrical / Q000175:diagnosis / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D008297:Male