title: Brain tissue oxygenation index measured by near infrared spatially resolved spectroscopy agreed with jugular bulb oxygen saturation in normal pediatric brain: a pilot study.
abstract: OBJECTIVE
  This observational, prospective pediatric human study was performed to determine the agreement between brain tissue oxygenation indices (TOI) measured by near infrared spatially resolved spectroscopy and jugular bulb oxygen saturation values (SjO(2)).
  
  
  METHODS
  Five cardiac patients without neurological impairment who were admitted into the critical care unit after open-heart surgery with jugular bulb venous catheters were enrolled. Their mean age was 8.6 months and mean body weight was 6.7 kg. Simultaneous measurements of brain TOI using NIR0-300 (Hamamatsu Photonics, Hamamatsu City, Japan) and SjO(2) values from blood samples were recorded.
  
  
  RESULTS
  The TOI range was 59+/-9% and the SjO(2) range was 58+/-17%. The correlation coefficient R was 0.64 (p=0.11; n=14). Bland-Altman plotting revealed a bias of -3.4%, and precision of 7.2% (n=14). Intra-class correlation reliability analysis showed kappa of 0.55.
  
  
  CONCLUSIONS
  Statistically, brain TOI was in reasonable agreement with SjO(2) in pediatric patients with normal brain within the measurement range from 50 to 70%.
authors.affiliation: Department of Critical Care Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. nshimizu@tkm.att.ne.jp <nshimizu@tkm.att.ne.jp>
authors.forename: Naoki
authors.initials: N
authors.lastname: Shimizu
authors.forename: Fay
authors.initials: F
authors.lastname: Gilder
authors.forename: Bruno
authors.initials: B
authors.lastname: Bissonnette
authors.forename: John
authors.initials: J
authors.lastname: Coles
authors.forename: Desmond
authors.initials: D
authors.lastname: Bohn
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Miyasaka
mesh_terms: D001784:Blood Gas Analysis / Q000379:methods; D001835:Body Weight; D001921:Brain / Q000098:blood supply* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005069:Evaluation Studies as Topic; D005260:Female; D006331:Heart Diseases / Q000097:blood; D006801:Humans; D007223:Infant; D007601:Jugular Veins / Q000378:metabolism*; D008297:Male; D008991:Monitoring, Physiologic; D010092:Oximetry / Q000379:methods; D010100:Oxygen / Q000097:blood*; D010865:Pilot Projects; D011446:Prospective Studies; D012016:Reference Values; D019265:Spectroscopy, Near-Infrared / Q000379:methods
chemical_list: D010100:Oxygen