title: Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica.
abstract: The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated. Activity-guided fractionation of MeOH extract resulted in the isolation of ursolic acid lactone, ursolic acid, pomolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid. Antiproliferative activity of the isolated compounds against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells was estimated.
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Yoshida
authors.forename: Masahiro
authors.initials: M
authors.lastname: Fuchigami
authors.forename: Tsuneatsu
authors.initials: T
authors.lastname: Nagao
authors.forename: Hikaru
authors.initials: H
authors.lastname: Okabe
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Jiro
authors.initials: J
authors.lastname: Takata
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Karube
authors.forename: Ryota
authors.initials: R
authors.lastname: Tsuchihashi
authors.forename: Junei
authors.initials: J
authors.lastname: Kinjo
authors.forename: Kunihide
authors.initials: K
authors.lastname: Mihashi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Fujioka
mesh_terms: D019661:Apiaceae; D049109:Cell Proliferation / Q000187:drug effects*; D028041:Centella; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053630:Depsides; D006131:Growth Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000097123:Rosmarinic Acid
chemical_list: D002934:Cinnamates; D053630:Depsides; D006131:Growth Inhibitors; D010936:Plant Extracts; D014315:Triterpenes; D000097123:Rosmarinic Acid