Molecular mechanisms of muscle atrophy.
Skeletal muscle atrophy has extreme adverse consequences. Molecular mechanisms that mediate the process of atrophy are not well defined. Recent studies have focused on diverse molecular cascades that control the activation of ubiquitin ligases, indicating that the involvement of the ubiquitin proteasome may be common to a range of atrophic stimuli.
McKinnell
Iain W
IW
Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.
Rudnicki
Michael A
MA
D000818:Animals; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology*; D009133:Muscular Atrophy / Q000378:metabolism* / Q000473:pathology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D014452:Ubiquitins / Q000378:metabolism
D014452:Ubiquitins; D046988:Proteasome Endopeptidase Complex