title: Copper-free sonogashira coupling reaction with PdCl2 in water under aerobic conditions.
abstract: A mild protocol for the copper-free Sonogashira coupling of aryl iodides with terminal acetylenes in water under aerobic conditions has been developed. The use of 1 mol % PdCl(2) in the presence of pyrrolidine allows the coupling reaction to proceed at room temperature or 50 degrees C with good to excellent yields.
authors.affiliation: Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Beijing 100871, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liang
authors.forename: Mingji
authors.initials: M
authors.lastname: Dai
authors.forename: Jiahua
authors.initials: J
authors.lastname: Chen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang