[Pindolol determination in pharmaceuticals by the method of capillary isotachophoresis].
Capillary izotachophoresis (ITP) with conductimetric detection was employed to determine pindolol (PI) in the pharmaceutical preparation Apo-pindol. The optimal operational electrolytic system was composed of 10 mM of potassium picolinate and 10 mM picolinic acid (leading electrolyte, LE; pH=5.1) and 10 mM of formic acid as the terminating electrolyte (TE). The time and currents mode of analysis were 50 microA (800 s), 10 microA. The total period of analysis was about 19 minutes. The method is suitable for the determination of PI in Apo-pindol tablets, RSD=1.45% (n=6). The method was validated from the viewpoint of precision, accuracy, and linearity of the ITP method. The accuracy of the method was determined by an analysis of a sample with an added standard and the recovery was 98.0%.
Kavalírová
A
A
Katedra analytické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové. kavalirova@faf.cuni.cz
Pospísilová
M
M
Hamoudová
R
R
D019075:Electrophoresis, Capillary / Q000379:methods; D010869:Pindolol / Q000032:analysis*; D013607:Tablets
D013607:Tablets; D010869:Pindolol