New synthesis of benzothiazines and benzoisothiazoles containing a sulfoximine functional group.
The reaction of S-2-bromophenyl-S-methylsulfoximine with terminal alkynes in the presence of a palladium catalyst resulted in the formation of both 1,2-benzothiazines and 1,2-benzoisothiazoles. A preference for the former was seen with alkylalkynes, while the latter were preferentially formed with alkynylarenes.
Harmata
Michael
M
Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA. harmatam@missouri.edu
Rayanil
Kanok-On
KO
Gomes
Maria G
MG
Zheng
Pinguan
P
Calkins
Nathan L
NL
Kim
Soo-Yeun
SY
Fan
Yimin
Y
Bumbu
Valentina
V
Lee
Dong Reyoul
DR
Wacharasindhu
Sumrit
S
Hong
Xuechuan
X