Functional variation of HIV-1 Rev Response Element in a longitudinally studied cohort.
We showed previously that HIV-1 Rev Response Element (RRE) contains a certain degree of structural variation, and in a set of limited samples, RRE from HIV-1 natural isolates were found to have functional variability. The significance of the RRE heterogeneity is addressed further by analyzing the functional variation of RREs in a longitudinal cohort. While the RRE activity at early time points was not a good predictor of disease outcome, the RRE activity at late time points was correlated with rates of CD4+ count decline. These data suggest that RRE heterogeneity may be important in viral pathogenesis and disease progression.
Phuphuakrat
Angsana
A
Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Paris
Robert M
RM
Nittayaphan
Sorachai
S
Louisirirotchanakul
Suda
S
Auewarakul
Prasert
P
D000328:Adult; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D004279:DNA, Viral; D018450:Disease Progression; D005260:Female; D015752:Genes, env / Q000235:genetics / Q000502:physiology*; D018740:Genetic Heterogeneity; D016655:HIV Core Protein p24 / Q000032:analysis; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male
D004279:DNA, Viral; D016655:HIV Core Protein p24