Quasispecies dynamics and RNA virus extinction.
The extinction of foot-and-mouth disease virus (FMDV) is strongly influenced by mutation rates, types of mutations, relative viral fitness and virus population regimens during infection. Here we review experimental results and theoretical models that describe a contrast between the effective extinction of FMDV subjected to increased mutagenesis, and the remarkable resistance to extinction of the same and related FMDV clones subjected to serial bottleneck events. The results suggest procedures to master key parameters to develop effective antiviral strategies based on virus entry into error catastrophe.
Domingo
Esteban
E
Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Consejo Superior de Investigaciones Cientificas, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. edomingo@cbm.uam.es
Escarmís
Cristina
C
Lázaro
Ester
E
Manrubia
Susanna C
SC
D000818:Animals; D001374:Azacitidine / Q000494:pharmacology; D005075:Biological Evolution; D005472:Fluorouracil / Q000494:pharmacology; D029544:Foot-and-Mouth Disease Virus / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation
D009153:Mutagens; D001374:Azacitidine; D005472:Fluorouracil