Postsynaptic scaffold proteins at non-synaptic sites. The role of postsynaptic scaffold proteins in motor-protein-receptor complexes.
Synapse-associated proteins that are located at the postsynaptic density (PSD) have recently been shown to have a structural role at non-synaptic locations. Here, they act as adaptor proteins between neurotransmitter receptors and the microtubule- or microfilament-based motor-protein complexes that are responsible for transport to the PSD. The use of a common set of proteins that contain multiple domains for protein-protein interactions as both intracellular transport adaptors and synaptic scaffold proteins might contribute to the transport specificity and postsynaptic integration of receptors that underlie synapse formation and plasticity.
Kneussel
Matthias
M
Zentrum für Molekulare Neurobiologie Hamburg, ZMNH, Universität Hamburg, Falkenried 94, D-20251 Hamburg, Germany. matthias.kneussel@zmnh.uni-hamburg.de
D000818:Animals; D008870:Microtubules / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D021381:Protein Transport; D013569:Synapses / Q000737:chemistry / Q000378:metabolism