Terminalia arjuna (Roxb.) protects rabbit heart against ischemic-reperfusion injury: role of antioxidant enzymes and heat shock protein.
The bark of Terminalia arjuna Roxb. (TA) is widely recommended for the treatment of ischemic heart disease (IHD) in Indian system of medicine. Oral administration of TA for 12 weeks in rabbits caused augmentation of myocardial antioxidants; superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) along with induction of heat shock protein72 (HSP72). In vivo ischemic-reperfusion injury induced oxidative stress, tissue injury of heart and haemodynamic effects were prevented in the TA treated rabbit hearts. The study provides scientific basis for the putative therapeutic effect of TA in ischemic heart disease.
Gauthaman
K
K
Department of Pharmacology, All India Institute of Medical sciences, New Delhi 110029, India.
Banerjee
S K
SK
Dinda
A K
AK
Ghosh
C C
CC
Maulik
S K
SK
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015153:Blotting, Western; D002374:Catalase / Q000378:metabolism; D029764:Combretaceae; D005260:Female; D005978:Glutathione / Q000378:metabolism; D050884:HSP72 Heat-Shock Proteins; D006339:Heart Rate / Q000187:drug effects; D006360:Heat-Shock Proteins / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000627:therapeutic use; D011817:Rabbits; D015427:Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D010936:Plant Extracts; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione