title: Long-term follow-up of an adolescent who had bilateral striatal necrosis secondary to Mycoplasma pneumoniae infection.
abstract: We describe the long-term follow-up of a patient with bilateral striatal necrosis associated with Mycoplasma pneumoniae infection occurred in adolescence. In the literature there are no longitudinal studies of such a rare condition. Our patient, 4 years after the onset of an acute and reversible akinetic-rigid syndrome, showed a severe obsessive-compulsive disorder, cognitive decline, and a neuropsychological profile characterized by signs of deficient executive functioning. The clinical picture that emerged in our patient is suggestive of a frontosubcortical dementia which might be considered a major long-term sequela of the bilateral selective striatal necrosis and consequent dysfunction of frontostriatal connections.
authors.affiliation: Child Neuropsychiatry Unit, University of Insubria, Via F. del Ponte 19, 21100 Varese, Italy.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Termine
authors.forename: Carla
authors.initials: C
authors.lastname: Uggetti
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Veggiotti
authors.forename: Umberto
authors.initials: U
authors.lastname: Balottin
authors.forename: Giorgio
authors.initials: G
authors.lastname: Rossi
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Egitto
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lanzi
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid; D001480:Basal Ganglia Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D001929:Brain Edema / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D003342:Corpus Striatum / Q000473:pathology* / Q000503:physiopathology; D003704:Dementia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D018450:Disease Progression; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011019:Pneumonia, Mycoplasma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D035583:Rare Diseases / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D012698:Serologic Tests
chemical_list: D000907:Antibodies, Bacterial