Physiological roles of prolactin-releasing peptide.
Prolactin-releasing peptide (PrRP) was first isolated from bovine hypothalamus as an orphan G-protein-coupled receptor using the strategy of reverse pharmacology. The initial studies showed that PrRP was a potent and specific prolactin-releasing factor. Morphological and physiological studies, however, indicated that PrRP may play a wide range of roles in neuroendocrinology other than prolactin release, i.e., metabolic homeostasis, stress responses, cardiovascular regulation, gonadotropin secretion, GH secretion and sleep regulation. This review will provide the current knowledge of PrRP, especially its roles in energy metabolism and stress responses.
Sun
Binggui
B
Department of Regulation Biology, Faculty of Science, Saitama University, 255 Shimo-ohkubo, Saitama 338-0825, Japan.
Fujiwara
Ken
K
Adachi
Sachika
S
Inoue
Kinji
K
D000818:Animals; D002417:Cattle; D004734:Energy Metabolism / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007028:Hypothalamic Hormones / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology*; D011388:Prolactin / Q000378:metabolism; D056690:Prolactin-Releasing Hormone; D018013:Receptors, Neuropeptide / Q000502:physiology*
D007028:Hypothalamic Hormones; D009479:Neuropeptides; C534377:PRLH protein, human; D056690:Prolactin-Releasing Hormone; D018013:Receptors, Neuropeptide; C400801:receptor, prolactin-releasing peptide; D011388:Prolactin