Effect of nimesulide co-administration on pharmacokinetics of lithium.
In a crossover study, lithium was given orally at a dose of 56 mg/kg, prepared as suspension (0.5%) in carboxymethyl cellulose (CMC) and blood samples (1 ml) collected after 0-24 hr after drug administration. After a washout period of two weeks, nimesulide (10 mg/kg) was administered alongwith lithium (56 mg/kg) and blood samples were drawn at the same time intervals (0-24 hr) after drug administration. Plasma was separated and assayed for lithium by M 654 Na+/K+/Li+ analyzer and various pharmacokinetic parameters were calculated. C(max), K(el), t(1/2el) and AUC(0-alpha) of lithium were significantly increased when nimesulide was administered along with lithium as compared to control group.
Sidhu
Shabir
S
Department of Pharmacology, Postgraduate Institute of Medical, Education & Research, Chandigarh 160012, India.
Kondal
Amit
A
Malhotra
Samir
S
Garg
S K
SK
Pandhi
P
P
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D004347:Drug Interactions; D008094:Lithium / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D011817:Rabbits; D013449:Sulfonamides / Q000008:administration & dosage*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014150:Antipsychotic Agents; D013449:Sulfonamides; D008094:Lithium; C012655:nimesulide