[Relationship of expression of leukemia inhibitory factor gene with progesterone and estradiol in mouse endometrium].
Leukemia inhibitory factor(LIF) is a glycoprotein with multiple activities, it expresses violently in most mice endometrium on 4-5 day of pregnancy,however the mechanism of LIF gene expression was not known completely. LIF gene expression was examined in endometrium of 168 mice and the concentrations of progesterone and estradiol were measured in their serum on 4-5 day. The expression of LIF gene was totally absent in 18 mice,and their concentrations of progesterone and estradiol in serum were significantly lower than the others. We discussed the relation between the expression of LIF gene with the concentration of two hormones. It was showed that the expression of LIF gene might be partly controlled by progesterone and estradiol.
Wong
Ya-Guang
YG
Department of Genetics, Chongqing University of Medical Sciences, Chongqing 400016, China.
Wang
Ying-Xiong
YX
Liu
Xue-Qing
XQ
He
Jun-Lin
JL
Chen
Xue-Mei
XM
Feng
Ya-Hong
YH