title: Dysfunctional baroreflex regulation of sympathetic nerve activity in remitted patients with panic disorder. A new methodological approach.
abstract: BACKGROUND
  Many researchers have studied the abnormalities of autonomic nervous system (ANS) such as decreased heart rate variability, which is a risk factor for sudden cardiac death, in patients with panic disorder (PD). However, no consistent abnormality has been uncovered to date. One of the reasons for this controversy may be due to the fact that most of these conventional studies have analyzed each physiological variable independent of other indices. We examined the ANS in PD patients using a new method which can more directly investigate the function of the baroreflex by examining the relation between the blood pressure (BP) and heart rate (HR).
  
  
  METHODS
  During rest and audiovisual stimulation (AS) as mental stress such as being exposed to video imaginary of experiences such as driving motor vehicles, cardiovascular parameters, HR and BP were consecutively measured in 13 remitted PD patients and twenty aged and gender-matched normal controls (NC). In this study, to assess the cardiovascular ANS function (baroreflex) in PD we used the power spectrum analysis as usual and the mean of lag time (tau) between the Mayer wave components, which was closely related to sympathetic nerve activity of vasomotor, of HR and BP variability as a new trial.
  
  
  RESULTS
  The PD patients and NC did not differ with regard to the power spectrum analysis of the heart rate. We found that tau in the PD group was significantly shorter than that in the NC both before and after AS, especially before.
  
  
  CONCLUSIONS
  These findings suggest that remitted PD patients may have a dysfunctional baroreflex regulation of sympathetic nerve activity.
authors.affiliation: Dept. of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi, Niigata 951-8510, Japan. tshioiri@med.niigata-u.ac.jp
authors.forename: Toshiki
authors.initials: T
authors.lastname: Shioiri
authors.forename: Maki
authors.initials: M
authors.lastname: Kojima-Maruyama
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hosoki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kitamura
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoshizawa
authors.forename: Takehiko
authors.initials: T
authors.lastname: Bando
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Someya
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000704:Analysis of Variance; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D007839:Functional Laterality; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000503:physiopathology*; D010775:Photic Stimulation / Q000379:methods; D013564:Sympathetic Nervous System / Q000503:physiopathology*