title: Relaxation-selective magnetization preparation based on T1 and T2.
abstract: A magnetization-preparation scheme is described that combines the spin-echo and inversion-recovery (SEIR) to select spins based on both T1 and T2 characteristics. The inclusion of T2 weighting allows for greater relative suppression of some tissues with respect to others, depending on their respective relaxation times, than does inversion-recovery alone. Formulae describing the observed magnetization following SEIR and double-SEIR (DSEIR) are presented with the corresponding formulae for inversion-recovery (IR) and double-IR (DIR). The formulae are validated with experimental studies on MnCl2 solutions and compared numerically for a variety of possible applications. Results indicate that DSEIR may yield 2x or more signal than DIR in some potential applications.
authors.affiliation: Department of Biomedical Engineering, Radiology and Radiological Sciences, Institute of Imaging Science, Vanderbilt University, USA. mark.does@vanderbilt.edu
authors.forename: Mark D
authors.initials: MD
authors.lastname: Does
mesh_terms: D002712:Chlorides / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D017895:Manganese Compounds / Q000737:chemistry; D008962:Models, Theoretical; D019047:Phantoms, Imaging
chemical_list: D002712:Chlorides; D017895:Manganese Compounds; C025340:manganese chloride