[Tetraploid clones characterized by double 8;21 translocations in two patients with acute myeloid leukemia].
OBJECTIVE
To report two cases of leukemia with t(8;21) and tetraploid clones.


METHODS
R-banding technique was used.


RESULTS
Cytogenetic studies of BM cells at diagnosis revealed that each of the two cases had three related abnormal clones besides a normal one: 46, XY, t(8;21) (2%), 46, idem, add((7)(q31)(6.8%) and 92, idem x 2 (80.6%) in case 1 and 46, XX, t(8;21) (13.4%), 47, idem, + 4 (46.3%) and 94, idem x 2 (39.1%) in case 2. They did not obtain complete remission on chemotherapy and survived 4 and 6 months, respectively.


CONCLUSIONS
Tetraploid or near tetraploid clones are secondary events which are specifically associated with t(8;21) leukemia and the prognosis of patients with this kind of abnormal karyotype is poor.
Xue
Y
Y
Jiangsu Institute of Hematology, First Affiliated Hospital of Suzhou Medical College, Suzhou 215006.
Pan
Y
Y
Liu
Z
Z
Guo
Y
Y
Xie
X
X
D000328:Adult; D002648:Child; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D011123:Polyploidy; D011379:Prognosis; D012008:Recurrence; D014178:Translocation, Genetic / Q000235:genetics*