title: Transient decrease in cerebral white matter diffusivity on MR imaging in human herpes virus-6 encephalopathy.
abstract: We report a 16-month-old boy with human herpes virus-6 (HHV-6) encephalopathy showing transient abnormalities of the cerebral white matter on magnetic resonance imaging. Diffusion-weighted imaging (DWI) demonstrated diffuse high signal intensity in the bilateral cerebral white matter areas. The signal changes on DWI subsequently resolved, and cerebral atrophy resulted. The transient decrease in the cerebral white matter diffusivity seen in the present case may reflect axonal involvement secondary to the glial or neuronal damage in HHV-6 encephalopathy.
authors.affiliation: Department of Pediatrics, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan. manami-imed@umin.ac.jp
authors.forename: Manami
authors.initials: M
authors.lastname: Akasaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ehara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kamei
authors.forename: Shoichi
authors.initials: S
authors.lastname: Chida
mesh_terms: D001284:Atrophy / Q000175:diagnosis / Q000503:physiopathology / Q000821:virology; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000503:physiopathology / Q000821:virology*; D015654:Herpesvirus 6, Human; D006801:Humans; D007223:Infant; D008297:Male; D009410:Nerve Degeneration / Q000175:diagnosis / Q000503:physiopathology / Q000821:virology; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000821:virology; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D019349:Roseolovirus Infections / Q000175:diagnosis* / Q000503:physiopathology; D013687:Telencephalon / Q000473:pathology* / Q000503:physiopathology / Q000821:virology*