DNA-binding behavior of ruthenium(II) complexes containing both group 15 donors and 2,2':6',2''-terpyridine.
Tetrafluoroborate salts of cationic ruthenium complexes [Ru(kappa(3)-tpy)(EPh(3))(2)Cl](+) (tpy=2,2':6',2''-terpyridine; E=P, 1 or As, 2) containing both the group 15 donor ligands and tpy and their representative substitution products are reported. Weak interaction {C-H...X (X=Cl, F and pi) and pi-pi interaction} studies revealed the presence of a double helical motif in complex 1, while the complex 2 assumes a single helical motif. Intercalative mode of interaction of the complexes 1 and 2 with calf thymus DNA (ctDNA) has been supported by absorption titration studies.
Sharma
Sanjeev
S
Department of Chemistry, Awadhesh Pratap Singh University, Rewa 486 003 (M.P.), India.
Singh
Sanjay K
SK
Chandra
Manish
M
Pandey
Daya Shankar
DS
D000818:Animals; D002417:Cattle; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D012428:Ruthenium / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013053:Spectrophotometry
D009942:Organometallic Compounds; D011725:Pyridines; D012428:Ruthenium; D004247:DNA