[Study of antisense oligodeoxynucleotide in reversing multidrug resistance and inducing apoptosis of tumor cells].
OBJECTIVE
T o explore an approach to the reversal of multidrug resistance(MDR) of tumor cells.


METHODS
Antisense oligodeoxynucleotide (mdr-1-AS PS-ODN) was used.


RESULTS
A large amount of DNA fragments was found in mdr-1-AS PS-ODN treated K562/ADM cells and almost all the mdr-1+ K562/ADM cells underwent apoptosis.


CONCLUSIONS
mdr-1-AS PS-ODN could inhibit specifically mdr-1 gene expression, effectively reverse MDR of the tumor cells and promote ADM induced apoptosis of mdr-1+ K562/ADM.
Zhang
F
F
The Third Clinical College, Norman Bethune University of Medical Sciences, Changchun 130021.
Lin
Y
Y
Jiang
Y
Y
Zhang
X
X
D017209:Apoptosis / Q000235:genetics*; D053938:DNA Fragmentation; D016373:DNA, Antisense / Q000235:genetics*; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*
D016373:DNA, Antisense