Apomorphine (Apokyn) for advanced Parkinson's Disease.
Apomorphine (Apokyn) is now available for rescue treatment of "off" episodes in patients with advanced Parkinson's disease. It must be injected subcutaneously. Apomorphine in a variety of formulations has been used in Europe for many years. Like other dopamine agonists it can cause nausea and vomiting, orthostatic hypotension, drowsiness, "sleep attacks" and dyskinesias. It should be taken initially with an antiemetic to avoid nausea and vomiting.
D001058:Apomorphine / Q000008:administration & dosage / Q000009:adverse effects*; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions / Q000502:physiology; D006801:Humans; D009325:Nausea / Q000139:chemically induced; D010300:Parkinson Disease / Q000188:drug therapy*; D014839:Vomiting / Q000139:chemically induced
D018491:Dopamine Agonists; D001058:Apomorphine