Magnetic resonance imaging and surgical repair of cleft palate in a four-week-old canine (Canis familiaris): an animal model for cleft palate repair.
Successful cleft palate repair (palatoplasty) was accomplished in a male canine pup from a kindred with autosomal recessive transmission for a complete cleft palate phenotype. This case represents the potential application of a new animal model for cleft palate repair. This reproducible congenital defect provides a clinically relevant model to improve research into the human anomaly, as compared with previous iatrogenic or teratogenically induced animal models. This case report presents the basis for new repair techniques and for studying the genetic basis of the cleft palate defect.
Tolwani
Ravi
R
Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Hagan
Catherine
C
Runstadler
Jonathan
J
Lyons
Heather
H
Green
Sherril
S
Bouley
Donna
D
Rodriguez
Luis
L
Schendel
Stephen
S
Moseley
Michael
M
Daunt
David
D
Otto
Glen
G
Cork
Linda
L
D000818:Animals; D000831:Animals, Newborn; D002972:Cleft Palate / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D004285:Dogs; D008279:Magnetic Resonance Imaging; D008297:Male; D019647:Oral Surgical Procedures / Q000379:methods*; D019651:Plastic Surgery Procedures / Q000379:methods*; D016896:Treatment Outcome