title: Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients.
abstract: We prospectively examined brachial artery endothelial function using vascular ultrasound in 41 obese subjects treated with medical or surgical (gastric bypass) weight loss interventions. Surgical intervention produced greater weight loss and more pronounced improvement in endothelial function than medical treatment alone. Improved endothelial function with weight loss correlated strongly with fasting glucose but not with alteration in blood pressure, lipids, degree of weight loss, or plasma resistin concentrations. These data demonstrate that weight loss in markedly obese patients improves endothelial function and glycemic control that may represent important mechanisms of the cardiovascular benefit associated with weight reduction.
authors.affiliation: Evans Department of Medicine, Cardiology and Endocrinology Sections, Boston University School of Medicine, Boston, MA, USA. Noyan.Gokce@bmc.org
authors.forename: Noyan
authors.initials: N
authors.lastname: Gokce
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Vita
authors.forename: Marie
authors.initials: M
authors.lastname: McDonnell
authors.forename: Armour R
authors.initials: AR
authors.lastname: Forse
authors.forename: Nawfal
authors.initials: N
authors.lastname: Istfan
authors.forename: Maria
authors.initials: M
authors.lastname: Stoeckl
authors.forename: Izabella
authors.initials: I
authors.lastname: Lipinska
authors.forename: John F
authors.initials: JF
authors.lastname: Keaney
authors.forename: Caroline M
authors.initials: CM
authors.lastname: Apovian
mesh_terms: D000328:Adult; D001786:Blood Glucose; D001916:Brachial Artery / Q000187:drug effects / Q000502:physiology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology; D009765:Obesity / Q000503:physiopathology* / Q000601:surgery*; D011446:Prospective Studies; D011673:Pulsatile Flow; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D005996:Nitroglycerin