title: [Progress on the related mechanism in the development of bone and joint].
abstract: The embryonic development of bone and joint involves in complicated events for vertebrate limb. It originates from determined condensation of mesenchymal cells from lateral mesoderm. These cells and the overlying ectodermal jacket form limb buds at presumptive limb levels. Then, under the control of systemic factors, mesenchymal cells aggregate and differentiate to form cartilage blastemal elements that prefigure skeletal limb components. The latter develops into skeleton through endochondral ossification. The majority of the bones of the limb form by the endochondral mechanism. The formation of synovial joint system and bone development occur simultaneously. This article reviewed the progress on the related control mechanism in the development of bone and joint recently.
authors.affiliation: Shanghai Institute of Traumatology and Orthopaedics, Orthopaedic Department, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200 025, China. lxuemin98@yahoo.com.cn
authors.forename: Xue-Min
authors.initials: XM
authors.lastname: Lü
authors.forename: Lian-Fu
authors.initials: LF
authors.lastname: Deng
authors.forename: Qing-Ming
authors.initials: QM
authors.lastname: Yang
mesh_terms: D000818:Animals; D001846:Bone Development / Q000235:genetics / Q000502:physiology*; D001842:Bone and Bones / Q000196:embryology / Q000502:physiology*; D002454:Cell Differentiation; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology; D020219:Chondrogenesis / Q000235:genetics* / Q000502:physiology; D005801:Genes, Homeobox; D006801:Humans; D007596:Joints / Q000196:embryology / Q000502:physiology*; D018878:Limb Buds / Q000502:physiology; D008648:Mesoderm / Q000166:cytology / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D010012:Osteogenesis / Q000235:genetics