title: Effect of high intakes of fruit and vegetables on redox status in type 2 onset diabetes: a pilot study.
abstract: Evidence has accumulated indicating that oxidative stress may play a key role in the etiology of diabetic complications and the protective effects of antioxidant nutrients are a topic of intense research. The purpose of this study was both to obtain preliminary data on the effect of a diet high in fruit and vegetables on metabolic control and the oxidative status of patients with type 2 onset diabetes, and to identify the most useful biochemical parameters for future research. At the beginning of the study all subjects were asked to follow their usual diet and keep a seven-day food diary. Diabetic patients then received a dietary treatment designed to ensure a daily intake of 700-1000 g of fruit and vegetables; no dietary advice was given to controls. Dietary antioxidants, redox status markers, and parameters of metabolic control were measured in plasma and erythrocytes before and after the diet. Before following the diet, diabetic patients had lower levels of ascorbic acid, beta-carotene, and alpha-tocopherol/cholesterol ratio than controls. After the diet these parameters increased and there was also a reduction in total antioxidant capacity, uric acid, and malondialdehyde and a rise in reduced glutathione accompanied by a reduction in body mass index and cholesterol. In conclusion, a high consumption of fruit and vegetables by diabetic patients not receiving pharmacological treatment, seems to produce an improvement in some redox status parameters.
authors.affiliation: Istituto Superiore di Sanità, National Centre for Food Quality and Risk Assessment, Rome, Italy. giammas@iss.it
authors.forename: Stefania
authors.initials: S
authors.lastname: Giammarioli
authors.forename: Carmelina
authors.initials: C
authors.lastname: Filesi
authors.forename: Barbara
authors.initials: B
authors.lastname: Vitale
authors.forename: Anna
authors.initials: A
authors.lastname: Cantagallo
authors.forename: Francesco
authors.initials: F
authors.lastname: Dragoni
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Sanzini
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy*; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D005638:Fruit; D005978:Glutathione / Q000097:blood; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D014675:Vegetables; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000097:blood; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D001205:Ascorbic Acid; D001786:Blood Glucose; D002784:Cholesterol; D004043:Dietary Fiber; D005978:Glutathione; D006442:Glycated Hemoglobin; D008055:Lipids; D008315:Malondialdehyde; D024502:alpha-Tocopherol; D019207:beta Carotene