title: Changes in the tissue expression of the C-erbB-2 oncogen in the oral lichen ruber.
abstract: The aim of this study was to determine the expression intensity of c-erbB-2 antigen in oral lichen planus and erosive form of oral lichen in 30 patients, and to compare the obtained results with the inflammation intensity i.e. hyperkeratosis. The examination of expression intensity of c-erbB-2 antigen was conducted through immunohistochemical analysis by APAAP method. Obtained reaction of examined tissue antigen was positive in individual or in group cells of spinous epithelium layer and mosaically expressed. The reaction was negative in basal cell epithelium layer. Strong intensity reaction was observed in intercellular bridges of spinous cells layer. In control group, the reaction was of uniform strong intensity in all epithelium layers. The reaction was not dependent on the inflammation intensity in lesions but it was positively correlated with their degree of hyperkeratosis. Changed expression of c-erbB-2 antigen in OLR lesions reveals the possibility of potential malignant transformation of these lesions.
authors.affiliation: Department of Clinical Pathology Ljudevit Jurak, University Hospital Sestre milosrdnice, Zagreb, Croatia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Pirkić
authors.forename: Dolores
authors.initials: D
authors.lastname: Biocina-Lukenda
authors.forename: Ana
authors.initials: A
authors.lastname: Cekić-Arambasin
authors.forename: Dino
authors.initials: D
authors.lastname: Buković
authors.forename: Ljubomir
authors.initials: L
authors.lastname: Pavelić
authors.forename: Sime
authors.initials: S
authors.lastname: Sakić
mesh_terms: D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000378:metabolism; D007972:Leukoplakia, Oral / Q000378:metabolism; D017676:Lichen Planus, Oral / Q000378:metabolism* / Q000473:pathology*; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases