Randomized controlled trials on hepato-biliary-pancreatic surgery.
The randomized controlled trial (RCT) plays an important role not only in the performance of evidence-based medicine but also in the establishment of therapeutic guidelines. In this review, I analyzed RCTs on hepato-biliary-pancreatic surgery, particularly on malignant diseases. The number of RCTs on hepato-biliary-pancreatic cancers is smaller than that on other types of cancers. This might be related to their low resectability. In liver surgery, a recent increase in RCTs of operative techniques has almost established a standard transection method. In biliary tract and pancreatic cancers, only a few RCTs have been performed concerning operative strategy. Therefore, many issues should be solved by an adequate RCT observing statements of the Consolidated Standards of Reporting Trials.
Kaido
Toshimi
T
Department of Surgery, Otsu Municipal Hospital, 2-9-9 Motomiya, Otsu, Shiga 520-0804, Japan.
D001661:Biliary Tract Neoplasms / Q000601:surgery; D001662:Biliary Tract Surgical Procedures; D013505:Digestive System Surgical Procedures; D019317:Evidence-Based Medicine; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000601:surgery; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic