title: [Comparison of anti-hepatitis C virus (HCV) IgM and HCV-RNA detection in serum samples of patients with HCV infection].
abstract: Anti-HCV IgG is the routine assay for the diagnosis hepatitis C. But the method is ineffective in early detection of hepatitis C. We have detected anti-HCV IgM in hospital hepatitis C patients by Enzyme-Linked Immunosorbent Assay (ELISA) and compared the results with those of HCV-RNA and total antibody. Our studies indicate that anti-HCV IgM is detected in all hepatitis C marker positive sera. But the amount of anti-HCV IgM in HCV-RNA positive sera is significantly higher than that of in the corresponding negative sera. This subjects that anti-HCV IgM and HCV-RNA are somewhat correlated and they have different clinical interests. Anti-HCV IgM can be expected and hepatitis activities and its actual clinical interests are to be further studied.
authors.affiliation: 302nd Hospital of Chinese PLA, Beijing 100039.
authors.forename: Z
authors.initials: Z
authors.lastname: Lei
authors.forename: H
authors.initials: H
authors.lastname: Lu
authors.forename: F
authors.initials: F
authors.lastname: Han
authors.forename: H
authors.initials: H
authors.lastname: Shi
authors.forename: J
authors.initials: J
authors.lastname: Lu
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000097:blood* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology*; D006526:Hepatitis C / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood* / Q000235:genetics*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D012367:RNA, Viral; C044203:anti-IgM