[Pharmacogenetics: Important aspects for dermatology].
Pharmacogenetics, pharmacogenomics or metabonomics are terms reflecting a new trend in pharmacology taking into consideration individual factors which influence the effects of drugs. Examples in dermatology include glucose-6-phosphate dehydrogenase-polymorphism (DADPS), dihydropyrimidine dehydrogenase-deficiency (5-Fluoruracil), thiopurine-S-methyltransferase-deficiency (azathioprine), cytochrome P450 isoenzymes and transferases (drug allergy and allergic contact dermatitis), and intolerant reactions to NSAIDs.
Merk
H F
HF
Universität-Hautklinik, Klinik für Dermatologie and Allergologie der RWTH Aachen. hans.merk@post.rwth-aachen.de
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001379:Azathioprine / Q000009:adverse effects*; D003622:Dapsone / Q000009:adverse effects*; D003880:Dermatology / Q000379:methods* / Q000639:trends; D003875:Drug Eruptions / Q000175:diagnosis* / Q000235:genetics* / Q000517:prevention & control; D005472:Fluorouracil / Q000009:adverse effects*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods* / Q000639:trends; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003622:Dapsone; D001379:Azathioprine; D005472:Fluorouracil