Antibacterial activity from Penicillium corylophilum Dierckx.
A strain of Penicillium corylophilum isolated from Brazilian soil sample was submitted to different culture conditions to investigate the production of secondary metabolites with antimicrobial activity. The largest number of conidia was obtained after 5 days of incubation in oat medium and the highest level of antimicrobial activity was produced when the fungus culture was developed in the Czapek medium. The activity against Staphylococcus aureus was found only in the chloroform extract from Czapek culture broth, which also showed activity against Micrococcus luteus. Fumiquinozoline F was isolated from the active chloroform extract by using chromatographic methods. The minimal inhibitory concentration (MIC) values for M. luteus and S. aureus were 99 microg/ mL and 137microg/mL, respectively.
Silva
Marley Garcia
MG
Faculdade de Filosofia, Ciências e Letras de Formiga, Fundação Educacional Comunitária Formiguense, Avenida Dr Arnaldo de Senna, 328 CEP 35570 000 Formiga MG, Brazil.
Furtado
Niege Araçari Jacometti Cardoso
NA
Pupo
Mônica Tallarico
MT
Fonseca
Maria José Vieira
MJ
Said
Suraia
S
da Silva Filho
Ademar Alves
AA
Bastos
Jairo Kenupp
JK
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001938:Brazil; D003470:Culture Media / Q000737:chemistry; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D015394:Molecular Structure; D010407:Penicillium / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003470:Culture Media