[Modification of antitumor effect of vincristine by natural avermectins].
The effect of avermectins (aversectin C, aversectin C1 and avermectin B1) on the vincristine antitumor action with respect to murine transplantable tumors was studied. It was shown that both the natural avermectins mixtures and the individual avermectin B1 potentiated the antitumor action of vincristine on Ehrlich carcinoma, melanoma B16 and P388 lymphoid leukemia, including the vincristine resistant strain P388. Such an effect of the avermectins was observed only when they were administered after vincristine.
Driniaev
V A
VA
Mosin
V A
VA
Krugliak
E B
EB
Sterlina
T C
TC
Novik
T C
TC
Ermakova
N V
NV
Kublik
L N
LN
Levitman
M Kh
MKh
Shaposhnikova
V V
VV
Korystov
Iu N
IuN
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D000977:Antiparasitic Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage
D000972:Antineoplastic Agents, Phytogenic; D000977:Antiparasitic Agents; D014750:Vincristine; D007559:Ivermectin; C019264:avermectin