title: Associations with autoimmune disorders and HLA class I and II antigens in inclusion body myositis.
abstract: Whether autoimmune mechanisms play a role in the pathogenesis of inclusion body myositis (IBM) is unknown. Human leukocyte antigen (HLA) analysis in 52 patients, including 17 with autoimmune disorders (AIDs), showed that patients were more likely to have antigens from the autoimmune-prone HLA-B8-DR3 ancestral haplotype than healthy control subjects, irrespective of the presence of AIDs. Patients lacked the apparently protective HLA-DR53 antigen. The results provide further support for an autoimmune basis in IBM.
authors.affiliation: Department of Neurology, K5Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. ubadrising@lumc.nl
authors.forename: U A
authors.initials: UA
authors.lastname: Badrising
authors.forename: G M Th
authors.initials: GM
authors.lastname: Schreuder
authors.forename: M J
authors.initials: MJ
authors.lastname: Giphart
authors.forename: K
authors.initials: K
authors.lastname: Geleijns
authors.forename: J J G M
authors.initials: JJ
authors.lastname: Verschuuren
authors.forename: A R
authors.initials: AR
authors.lastname: Wintzen
authors.forename: M L C
authors.initials: ML
authors.lastname: Maat-Schieman
authors.forename: P
authors.initials: P
authors.lastname: van Doorn
authors.forename: B G M
authors.initials: BG
authors.lastname: van Engelen
authors.forename: C G
authors.initials: CG
authors.lastname: Faber
authors.forename: J E
authors.initials: JE
authors.lastname: Hoogendijk
authors.forename: A E
authors.initials: AE
authors.lastname: de Jager
authors.forename: P J
authors.initials: PJ
authors.lastname: Koehler
authors.forename: M
authors.initials: M
authors.lastname: de Visser
authors.forename: S G
authors.initials: SG
authors.lastname: van Duinen
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D015897:Comorbidity; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D006681:HLA-D Antigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics / Q000276:immunology; D059845:HLA-DRB4 Chains; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D018979:Myositis, Inclusion Body / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence
chemical_list: D006680:HLA Antigens; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; C050610:HLA-DR53; D059845:HLA-DRB4 Chains