Electrochemical behaviors of diethylstilbestrol and its application in pharmacokinetics.
The electrochemical behaviors of diethylstilbestrol (DES) at a glassy carbon electrode were investigated by cyclic voltammetry, linear sweep voltammetry, and differential pulse voltammetry (DPV). Based on these, a sensitive and selective DPV method was developed for determination of DES. The linear response range of DES is 1.0 x 10(-4)-2.0 x 10(-6) mol/L and the detection limit was 8.0 x 10(-8) mol/L. The developed method has been used for the pharmacokinetics of DES in rabbit blood plasma.
Bin
Qiu
Q
Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, China.
Wei
Wang
W
Chi
Yuwu
Y
Chen
Guonan
G
D000818:Animals; D004054:Diethylstilbestrol / Q000737:chemistry* / Q000493:pharmacokinetics*; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011817:Rabbits; D013501:Surface-Active Agents / Q000494:pharmacology
D013501:Surface-Active Agents; D004054:Diethylstilbestrol