title: Efficacy of boric-complexed zinc and acetic-complexed zinc otic preparations for canine yeast otitis externa.
abstract: The purpose of this 2-week, double-blinded, controlled clinical trial was to evaluate the efficacy of topical amino acid-complexed zinc gluconate formulated with boric acid (ZGB) or acetic acid (ZGA) versus a topical placebo in the treatment of yeast otitis externa in dogs. Included in the study were dogs with otitis externa and a cytopathological finding of yeast organisms in the affected ear. Ears were treated with the placebo, ZGA, or ZGB medications. Yeast counts as well as clinical appearance of the ears were monitored. Results revealed that ZGB significantly reduced the number of yeast organisms in cases of otitis externa.
authors.affiliation: Animal Dermatology Clinics, Tustin, California 92780, USA.
authors.forename: Colleen L
authors.initials: CL
authors.lastname: Mendelsohn
authors.forename: Craig E
authors.initials: CE
authors.lastname: Griffin
authors.forename: Wayne S
authors.initials: WS
authors.lastname: Rosenkrantz
authors.forename: Larry D
authors.initials: LD
authors.lastname: Brown
authors.forename: Mona J
authors.initials: MJ
authors.lastname: Boord
mesh_terms: D019342:Acetic Acid / Q000627:therapeutic use; D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D001888:Boric Acids / Q000627:therapeutic use; D015169:Colony Count, Microbial / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy* / Q000382:microbiology; D004285:Dogs; D004311:Double-Blind Method; D005942:Gluconates / Q000627:therapeutic use*; D010032:Otitis Externa / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D016896:Treatment Outcome; D015003:Yeasts / Q000187:drug effects* / Q000254:growth & development
chemical_list: D001888:Boric Acids; D005942:Gluconates; D019342:Acetic Acid; C030691:gluconic acid