title: Cycloisomerization of 1,6-enynes: asymmetric multistep preparation of a hydrindane framework in water with polymeric catalysts.
abstract: [Reaction: see text] Cycloisomerization of 1,6-enynes proceeded smoothly in water under heterogeneous conditions in the presence of a palladium complex supported on polystyrene-poly(ethylene glycol) copolymer resin to give the corresponding cyclopentanes with a high level of chemical greenness. Multistep asymmetric synthesis of a hydrindane framework was achieved via palladium-catalyzed asymmetric pi-allylic alkylation, propargylation, and cycloisomerization of 1,6-enynes, where all three steps were performed in water with recyclable polymeric catalysts.
authors.affiliation: Institute for Molecular Science (IMS), CREST, and Graduate University for Advanced Studies, Higashiyama 5-1, Myodaiji, Okazaki 444-8787, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakai
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Uozumi