title: Serum CA 125 combined with transvaginal ultrasonography for ovarian cancer screening.
abstract: BACKGROUND
  The aim of this study was to evaluate the combination of serum CA125 and Transvaginal Ultra Sonography (TVUS) score, as a screening procedure for ovarian cancer in premenopausal and postmenopausal women.
  
  
  METHODS
  A retrospective case-control pilot study was conducted. The files of 120 women with ovarian neoplasia detected by TVUS and increased CA125 level, within the framework of a prevention program, were reviewed. The relationship between the above tests and epithelial malignancy was investigated using the SPSS-12 program for Windows.
  
  
  RESULTS
  The combination of CA125 value exceeding 30U/ml and a TVUS score > or = 35 had a sensitivity of 81.7% and specificity of 100% in predicting ovarian cancer. Mathematical analysis of the logistic model of our variables revealed a mathematical model that can calculate the likelihood of ovarian cancer detection, by using a combination of CA125 > or = 30U/ml and TVUS score > or = 35.
  
  
  CONCLUSIONS
  By combining TVUS and CA125, an accurate prediction for the presence of ovarian cancer may be achieved. Further investigation in a larger population is warranted.
authors.affiliation: Department of Nursing, Faculty of Health Care Sciences, High Technological Education Institute, Larissa, Greece. zoeroupa@yahoo.gr
authors.forename: Zoi
authors.initials: Z
authors.lastname: Roupa
authors.forename: Efthimios
authors.initials: E
authors.lastname: Faros
authors.forename: Vasilios
authors.initials: V
authors.lastname: Raftopoulos
authors.forename: Georgios
authors.initials: G
authors.lastname: Tzavelas
authors.forename: Evangelia
authors.initials: E
authors.lastname: Kotrotsiou
authors.forename: Penelope
authors.initials: P
authors.lastname: Sotiropoulou
authors.forename: Evridiki
authors.initials: E
authors.lastname: Karanikola
authors.forename: Evdoxia
authors.initials: E
authors.lastname: Skifta
authors.forename: Alexandros
authors.initials: A
authors.lastname: Ardavanis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018394:CA-125 Antigen / Q000097:blood; D002277:Carcinoma / Q000175:diagnosis* / Q000517:prevention & control; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000517:prevention & control; D017698:Postmenopause; D011237:Predictive Value of Tests; D017697:Premenopause; D012189:Retrospective Studies; D014463:Ultrasonography; D014621:Vagina / Q000000981:diagnostic imaging*
chemical_list: D018394:CA-125 Antigen