title: [Advances in studies of biological clock gene].
abstract: The circadian clock genes, which generate and control the running of the circadian rhythms, exist in organisms ranging from prokaryotes to mammals. The oscillator genes and its coding proteins compose the feedback loops of circadian system. The kind, number and regulating route of clock genes are characterized by living things at different evolution levels. The molecular mechanism of the run of circadian clock genes in cyanobacteria, neurospore, fruit fly, mouse and human being is introduced in this article.
authors.affiliation: Chronobiology Laboratory, Shenyang Pharmaceutical University, Shenyang 110016, China. ljingcai2001@hotmail.com
authors.forename: Jing-Cai
authors.initials: JC
authors.lastname: Li
authors.forename: Duo
authors.initials: D
authors.lastname: Yu
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: He
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000235:genetics* / Q000502:physiology; D056926:CLOCK Proteins; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology; D000458:Cyanobacteria / Q000235:genetics* / Q000502:physiology; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology; D009492:Neurospora crassa / Q000235:genetics* / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology
chemical_list: D018797:Cell Cycle Proteins; D047908:Intracellular Signaling Peptides and Proteins; C509769:TIMELESS protein, human; D015534:Trans-Activators; D056926:CLOCK Proteins; C538943:CLOCK protein, human; C538944:Clock protein, mouse