In vitro anti-proliferation/cytotoxic activity of sixty natural products on the human SH-SY5Y neuroblastoma cells with specific reference to dibenzyl trisulphide.
Sixty natural products belonging to the following structural classes: artemisinins, coumarins, flavonoids, tannins, tetrahydroberberine alkaloids, tetracyclic triterpenes, tetranortriterpenoids and polysulphides were screened against the human SH-SY5Y neuroblastoma cell line revealing differences in their effects on cell morphology and in anti-proliferation/cytotoxic activity. Based on the data obtained, dibenzyl trisulphide is the most effective anti-proliferative/cytotoxic compound. In addition, we hereby propose the human SH-SY5Y cell line as a sensitive and uncomplicated in vitro test system for detecting compounds with potential anti-proliferation/cytotoxic activity.
Williams
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LA
The Institutes of Bio-organic Chemistry and Zoology, University of Hohenheim, Garbenstrasse 30, D-70593 Stuttgart, Germany. lawrencew@src-jamaica.org
Rösner
H
H
Möller
W
W
Conrad
J
J
Nkurunziza
J P
JP
Kraus
W
W
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009447:Neuroblastoma / Q000473:pathology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013440:Sulfides / Q000494:pharmacology*
D000970:Antineoplastic Agents; D001593:Benzyl Compounds; D010936:Plant Extracts; D013440:Sulfides; C495415:dibenzyl trisulfide