title: [Report of a rare distal arthrogrophy large family].
abstract: We describe a seven-generation large family with talipomanus and talipes, 175 individuals in this family were involved. 32 affected individuals including 18 males and 14 females whose clinical features were different and 1 suspicious male were found. The talipomanus were symmetrical, and varus and valgus were caused by vertical talus. We investigated their living environment, the dietary habit, obstetrical history, physical status, lifespan, and studied cytogenetics and so on. We propose these defects were rare distal arthrogrophy genetic disease.
authors.affiliation: Liaoning Open Laboratory of Reproductive Medicine, Shenyang 110031,China. jiangmiaocpt@yahoo.com.cn
authors.forename: Miao
authors.initials: M
authors.lastname: Jiang
authors.forename: Wei-Tian
authors.initials: WT
authors.lastname: Han
authors.forename: Chao-Ying
authors.initials: CY
authors.lastname: Bian
authors.forename: Ge
authors.initials: G
authors.lastname: Wang
authors.forename: Wei-Zhou
authors.initials: WZ
authors.lastname: Li
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Sun
authors.forename: Ze
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000328:Adult; D001176:Arthrogryposis / Q000235:genetics* / Q000473:pathology*; D005192:Family Health; D005260:Female; D005532:Foot Deformities, Congenital / Q000000981:diagnostic imaging / Q000235:genetics; D006228:Hand Deformities, Congenital / Q000000981:diagnostic imaging / Q000235:genetics; D006801:Humans; D008297:Male; D010375:Pedigree; D011859:Radiography