title: [Castleman's disease].
abstract: METHODS
  A 25-year-old patient with fever, dysphagia, and reduced general condition was referred to our department by his dentist after 1 week of antibiotic therapy. He presented with a painful palpable mass in the right lower jaw that had developed 2 weeks before. The orthopantomogram showed a caries and periapical lesion at the right lower wisdom tooth. During extraction of the tooth and putative intra- and extraoral abscess incision, no pus could be drained and the mass persisted. CT scans then revealed lobulated soft tissue masses on both sides of the neck with the main focus on the right side. In an additional operation with excision of the mass, Castleman's disease of the hyaline vascular type was diagnosed.
  
  
  RESULTS
  Staging could not detect further pathological findings and the patient's postoperative general condition improved continuously. The histological features of the hayline vascular type of Castleman's disease were characterized by multiple germinal centers surrounded by circumferentially arranged layers of small lymphocytes interconnected by a prominent vascular stroma with occasional plasma cells ("onion skin").
  
  
  CONCLUSIONS
  Castleman's disease is a rare and yet poorly understood disease, characterized by inhomogeneous growth of lymphoid tissue. Mostly benign it remains a diagnostic challenge before histological investigation. In unclear submandibular swellings and neck lumps assumed to be an abscess, this rare differential diagnosis must be considered. Facing recurrence and potential for malignancy, follow-up of the patients over several years is necessary.
authors.affiliation: Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie der Ruhr-Universität Bochum, Knappschaftskrankenhaus Bochum-Langendreer, 44892 Bochum. frank.hoelzle@ruhr-uni-bochum.de
authors.forename: F
authors.initials: F
authors.lastname: Hölzle
authors.forename: A
authors.initials: A
authors.lastname: Landers
authors.forename: C
authors.initials: C
authors.lastname: Platz-Baudin
authors.forename: D
authors.initials: D
authors.lastname: Basrei
authors.forename: K-D
authors.initials: KD
authors.lastname: Wolff
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000175:diagnosis* / Q000601:surgery; D003680:Deglutition Disorders / Q000209:etiology*; D003937:Diagnosis, Differential; D005335:Fever of Unknown Origin / Q000209:etiology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008334:Mandible; D008964:Molar, Third / Q000601:surgery; D010482:Periapical Abscess / Q000175:diagnosis / Q000601:surgery; D011862:Radiography, Panoramic; D014057:Tomography, X-Ray Computed