title: An experimental study of chromatographic dynamics in open and packed non-cylindrical conduits.
abstract: A systematic investigation of the influence of the perimeter shape of open and particle packed fused silica capillaries on chromatographic properties such as resistance to flow and dispersion of solutes propelled through these channels has been conducted. Verifications of these uncommon experiments with existing theoretical treatments are presented and the insights transferred to a novel polymer chip design with integrated facilities for complex separations. A comparison of the chromatographic performance of a real life proteomics sample on this chip with a capillary column of "similar" dimensions is presented.
authors.affiliation: Agilent Technologies Inc, Palo Alto, CA, USA. gerard_rozing@agilent.com
authors.forename: Gerard
authors.initials: G
authors.lastname: Rozing
authors.forename: Tom
authors.initials: T
authors.lastname: van de Goor
authors.forename: Hongfeng
authors.initials: H
authors.lastname: Yin
authors.forename: Kevin
authors.initials: K
authors.lastname: Killeen
authors.forename: Bernd
authors.initials: B
authors.lastname: Glatz
authors.forename: Karsten
authors.initials: K
authors.lastname: Kraiczek
authors.forename: Henk H
authors.initials: HH
authors.lastname: Lauer
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D019075:Electrophoresis, Capillary / Q000295:instrumentation*; D010539:Permeability