title: Hepatoprotective effect of sesquiterpenes in turmeric.
abstract: Hepatoprotective effect of turmeric together with its sesquiterpenes and curcuminoids fractions were examined on D-galactosamine induced liver injury in rats. All the diets individually contained the turmeric extract, the curcuminoids fraction, and the sesquiterpenes fraction suppressed the increase of LDH, ALT, and AST levels caused by D-GalN treatment. Since few anti-oxidative activities are expected in the sesquiterpenes fraction, it is presumed that hepatoprotective mechanism of sesquiterpenes in turmeric is different from that of curuminoids.
authors.affiliation: Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089-8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729-3102, Japan. m-miyakoshi@maruzenpcy.co.jp
authors.forename: Masazumi
authors.initials: M
authors.lastname: Miyakoshi
authors.forename: Yasunaga
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Ryoji
authors.initials: R
authors.lastname: Takagaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Mizutani
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kambara
authors.forename: Takao
authors.initials: T
authors.lastname: Ikeda
authors.forename: M S
authors.initials: MS
authors.lastname: Zaman
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kakihara
authors.forename: Asako
authors.initials: A
authors.lastname: Takenaka
authors.forename: Kiharu
authors.initials: K
authors.lastname: Igarashi
mesh_terms: D000818:Animals; D030024:Curcuma; D000431:Ethanol; D005688:Galactosamine / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D012717:Sesquiterpenes; D000431:Ethanol; D005688:Galactosamine