title: Myocarditis and sacroiliitis: 2 previously unrecognized manifestations of tumor necrosis factor receptor associated periodic syndrome.
abstract: Tumor necrosis factor receptor associated periodic syndrome (TRAPS) is an autosomic-dominant periodic syndrome associated with mutations in the extracellular domain of the 55 kDa TNF receptor. Clinically, episodes of severe myalgia, arthralgia/arthritis, sterile peritonitis, scrotal inflammation, serositis, migratory rash, conjunctivitis, and recurrent fever are characteristic. We describe a 9-year-old African American boy with the P46L mutation of the TNF receptor who presented with 2 previously unrecognized manifestations: sacroiliitis and myocardiopathy, both showing a reversible course.
authors.affiliation: Department of Rheumatology, Alfred I. duPont Hospital for Children, Wilmington, Delaware 19899, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Trost
authors.forename: Carlos D
authors.initials: CD
authors.lastname: Rosé
mesh_terms: D001168:Arthritis / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D002648:Child; D010505:Familial Mediterranean Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D005938:Glucocorticoids / Q000627:therapeutic use; D006579:Heterozygote; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009154:Mutation / Q000235:genetics; D009205:Myocarditis / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D011877:Radionuclide Imaging; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000235:genetics*; D020127:Recovery of Function; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D047888:Receptors, Tumor Necrosis Factor, Type I; D008775:Methylprednisolone; D007213:Indomethacin