title: Neurofibrillary tangles in ALS and Parkinsonism-dementia complex focus in Kii, Japan.
abstract: Brains of 41 residents without neurodegenerative diseases in the high-incidence area of ALS/parkinsonism-dementia complex (ALS/PDC) of the Kii Peninsula of Japan were neuropathologically examined. Neurofibrillary tangles (NFTs) in the hippocampal area were present in 11 of the 41 cases, but the frequency of NFT-positive cases in each age group was similar to that of the normal Japanese population and far less than that of Guamanians without ALS/PDC.
authors.affiliation: Department of Neurology, Mie University School of Medicine, Tsu, Mie-ken, Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Kokubo
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kuzuhara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology*; D001921:Brain / Q000473:pathology*; D002423:Cause of Death; D002561:Cerebrovascular Disorders / Q000473:pathology; D016000:Cluster Analysis; D003704:Dementia / Q000453:epidemiology*; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008103:Liver Cirrhosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology; D009369:Neoplasms / Q000473:pathology*; D016874:Neurofibrillary Tangles / Q000473:pathology*; D010300:Parkinson Disease / Q000453:epidemiology*; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology; D014754:Violence