title: Anthocyan does not suppress transformation of aryl hydrocarbon receptor induced by dioxin.
abstract: Dioxins cause a variety of toxic effects through transformation of a cytosolic aryl hydrocarbon receptor (AhR). We have previously demonstrated that certain natural flavones and flavonols at the dietary levels suppress AhR transformation. In this study, we investigated whether 5 anthocyanidins, 15 anthocyanins, and protocatechuic acid suppress AhR transformation in mouse hepatoma Hepa-1c1c7 cells. All the compounds tested here at 5 microM unexpectedly failed to suppress the transformation induced by 0.1 nM TCDD, indicating that anthocyan does not have a potential to prevent dioxin toxicity.
authors.affiliation: Laboratory of Food and Nutritional Chemistry, Faculty of Agriculture, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8501, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Mukai
authors.forename: Itsuko
authors.initials: I
authors.lastname: Fukuda
authors.forename: Shin
authors.initials: S
authors.lastname: Nishiumi
authors.forename: Keizo
authors.initials: K
authors.lastname: Hosokawa
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kanazawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ashida
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D062385:Hydroxybenzoates / Q000494:pharmacology; D008113:Liver Neoplasms; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D018336:Receptors, Aryl Hydrocarbon / Q000096:biosynthesis* / Q000187:drug effects
chemical_list: D000872:Anthocyanins; D062385:Hydroxybenzoates; D010936:Plant Extracts; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; C009091:protocatechuic acid