[Effects of Yangyin Shengjin Decoction on hemorheological parameters and coagulation factors in model rabbits with syndrome of excessive heat consuming body fluid and blood stasis].
OBJECTIVE
To investigate the effects of Yangyin Shengjin Decoction (YYSJD) on hemorheological parameters and coagulation factors in model rabbits with syndrome of excessive heat consuming body fluid and blood stasis.


METHODS
Rabbit model with syndrome of excessive heat consuming body fluid and blood stasis was produced. The effects of YYSJD on the blood viscosity, erythrocyte sedimentation rate (ESR), hematocrit, platelet aggregation rate, prothrombin time (PT), thrombin time (TT), kaolin partial thromboplastin time (KPTT), fibrinogen (Fg), thromboxane B(2) (TXB(2)), and 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)) in the model rabbits were observed.


RESULTS
YYSJD decreased the whole blood viscosity and hematocrit, inhibited the platelet aggregation, prolonged PT, TT and KPTT, and reduced the content of Fg. It also regulated the balance between TXB(2) and 6-keto-PGF(1alpha).


CONCLUSIONS
YYSJD can promote the blood circulation, adjust the blood agglutinating function, and decrease the formation of thrombus. This is one of the pharmacological mechanisms of the therapeutic method of "nourishing yin to promote blood circulation" in the theory of traditional Chinese medicine for seasonal febrile diseases.
Ma
Hong
H
College of Basic Medical Sciences, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China. mhhome603@sina.com
Yang
Jin
J
Nan
Shu-Ling
SL
Gong
Jie-Ning
JN
Liu
Xue-Feng
XF
D000818:Animals; D001779:Blood Coagulation Factors / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects; D003141:Communicable Diseases / Q000139:chemically induced / Q000188:drug therapy*; D003937:Diagnosis, Differential; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D018056:Hemorheology; D008297:Male; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D011817:Rabbits; D013577:Syndrome
D001779:Blood Coagulation Factors; D004365:Drugs, Chinese Herbal