title: Dynamics from picoseconds to nanoseconds of trehalose in aqueous solutions as seen by quasielastic neutron scattering.
abstract: We present a study of the dynamical behavior of trehalose, a cryoprotecting agent, in concentrated aqueous solutions. Dynamics in a wide time range from picoseconds to nanoseconds has been observed using both neutron time of flight and neutron spin-echo techniques. Fast dynamics has been described using a simple diffusion model, while dynamical processes at longer times show a more complex behavior, described by a stretched exponential decay. Obtained relaxation times show a good agreement with data from viscosity measurements on aqueous trehalose solutions by Magazu et al. [Branca, Magazu, Maisano et al., J. Phys.: Condens. Matter 11, 3823 (1999)]. Experimental data provide us with some insight into the cryoprotecting properties and processes of trehalose. We conclude that an increase of the solvent viscosity in embedded biological material due to the production or the presence of trehalose might prevent biomolecules from damage.
authors.affiliation: Laboratoire Léon Brillouin, CEA-Saclay, F-91191 Gif-sur-Yvette Cedex, France.
authors.forename: I
authors.initials: I
authors.lastname: Köper
authors.forename: M-C
authors.initials: MC
authors.lastname: Bellissent-Funel
authors.forename: W
authors.initials: W
authors.lastname: Petry