title: Development of cellular magnesium nano-analysis in treatment of clinical magnesium deficiency.
abstract: A novel technique, using energy dispersive X-ray microanalysis (EXAtm), for noninvasive intracellular (i.c.) measurement of magnesium [Mg2+]i has now been accomplished and proven to be a valuable tool in multiple aspects of normal as well as pathological magnesium metabolism. Since only 1% of total body Mg2+ is found in the intravascular space, serum levels of Mg2+ give little information about a patient's overall Mg2+ status with respect to this essential mineral. Using the EXAtm analysis it has shown been determined that Mg2+ levels are significantly reduced in many physiological states which may lead to serious pathological conditions [15]. Description of the methodology and examples of data as well as potential applications will focus on intracellular (i.c.) [Mg2+]i determinations obtained in cells from subjects with cardiovascular disease (CVD) syndromes related to Mg2+ deficiency. Examples of the application of EXAtm evaluation include examination of intracellular magnesium and other minerals in a wide spectrum of conditions which include cardiovascular conditions, arrhythmias, heart failure, myocardial infarction, and bypass surgery. Standardization of control values were performed at NASA.
authors.affiliation: Department of Physiology & Biophysics, University of Louisville, School of Medicine, Louisville, Kentucky, USA. DocBurt@aol.com
authors.forename: Burton B
authors.initials: BB
authors.lastname: Silver
mesh_terms: D000818:Animals; D004577:Electron Probe Microanalysis / Q000379:methods*; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D008274:Magnesium / Q000032:analysis*; D008275:Magnesium Deficiency / Q000175:diagnosis*; D008929:Mitochondria, Heart / Q000378:metabolism; D009060:Mouth Floor / Q000166:cytology; D011788:Quality of Life
chemical_list: D008274:Magnesium