Total synthesis of norneolignans from Krameria species.
The total synthesis of nomeolignans isolated from Krameria species, 2-aryl-5-(E)-propenylbenzofurans (5, 11), is described. The key step involves the one-pot reaction for 2-arylbenzofurans (2, 7) from 4-hydroxyphenylacetone with 4'-acetoxy-2-chloro-2-(methylthio)acetophenone (1) and 2-chloro-2-methylthio-(2',4',6'-trimethoxy)acetophenone (6) under Friedel-Crafts reactionconditions.
Seo
Pil-Ja
PJ
Department of Chemistry, Dongeui University, Busan 614-714, Korea. pjseo@deu.ac.kr
Choi
Hong-Dae
HD
Son
Byeng-Wha
BW
D031326:Krameriaceae; D017705:Lignans / Q000138:chemical synthesis* / Q000302:isolation & purification; D010936:Plant Extracts / Q000138:chemical synthesis / Q000302:isolation & purification; D018517:Plant Roots
D017705:Lignans; D010936:Plant Extracts