Genetics of vascular anomalies: an update.
Vascular anomalies arise from genetic, environmental, mechanical, and/or hormonal factors. Some are inherited in a Mendelian fashion whereas others result from abnormal chromosomal segregation during gametogenesis or appear sporadically during various stages of life. Understanding the molecular basis of vascular development and vascular anomalies provides potential tools for diagnosis and treatment of the diseases.
Chaft
Jamie E
JE
Department of Pediatrics, (Division of Hematology/Oncology), NYU Medical Center, New York, New York 10016, USA.
Steckman
David A
DA
Blei
Francine
F
D000818:Animals; D001808:Blood Vessels / Q000473:pathology / Q000502:physiology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000473:pathology*; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009389:Neovascularization, Pathologic; D015398:Signal Transduction; D014652:Vascular Diseases / Q000235:genetics* / Q000628:therapy