title: [The role of cytokines in the immunoreactivity modulation with bacteria of the Lactobacillus genus].
abstract: Mechanisms of the immunomodulating and anticancerogenic action of bacteria of the genus Lactobacillus are updated on the basis of recent publications andown research. The impact of lactobacteria on the production of cytokines by the host as one of the most important factors mediating the modulating properties of these microorganisms is considered. Information on the capacity of lactobacteria to exhibit stimulating and suppressing effects on the immune system, to maintain the development and support oral tolerance and to ensure antitumor action is presented. The role of different cell components of lactic acid bacteria in inducing the cytokines synthesis is discussed. The mechanisms of the immunomodulating action of different probiotic preparations for the prophylaxis and correction of immunodeficient states associated with the development of dysbacteriosis and acute enteric infections are analyzed. The data on the oncostatic action of bacteria of the genus Lactobacillus are presented.
authors.forename: T N
authors.initials: TN
authors.lastname: Nikolaeva
authors.forename: V V
authors.initials: VV
authors.lastname: Zorina
authors.forename: V M
authors.initials: VM
authors.lastname: Bondarenko
mesh_terms: D000970:Antineoplastic Agents; D001424:Bacterial Infections / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D016867:Immunocompromised Host / Q000276:immunology; D007155:Immunologic Factors; D007778:Lactobacillus / Q000276:immunology*; D009369:Neoplasms / Q000628:therapy; D019936:Probiotics / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D016207:Cytokines; D007155:Immunologic Factors