title: Thr54 allele of the FABP2 gene affects resting metabolic rate and visceral obesity.
abstract: We investigated the relationship between Ala54Thr variant allele of the fatty acid-binding protein 2 (FABP2) gene (Ala54Thr) and development of obesity in Japanese obese women. FABP2 genotypes were determined with a fluorescent allele-specific DNA primer assay system. Body weight, waist and hip circumference, amounts of visceral and subcutaneous white adipose tissue measured by computed tomography (CT) were compared between subjects with Thr allele and without Thr allele before and after the diet and exercise therapy in 80 Japanese obese women. The frequency of the Thr54 allele did not differ between obese and control subjects (0.388 versus 0.329, respectively). In subjects with Ala/Thr and Thr/Thr genotype, adjusted resting metabolic rate (RMR) was significantly lower than the subjects with Ala/Ala genotype. Subjects with the Thr54 allele showed significantly greater waist circumference after diet and exercise therapy than subjects with Ala/Ala genotype. They also demonstrated greater body weight at 20 years of age compared to subjects with Ala/Ala genotype. In conclusion, Thr54 allele of FABP2 has associations with lower adjusted resting metabolic rate, resistance in reducing visceral white adipose tissue (WAT) and early onset of obesity in Japanese obese women.
authors.affiliation: Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto 602 8566, Japan. ystaka@koto.kpu-m.ac.jp
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Takakura
authors.forename: Keiji
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Umekawa
authors.forename: Akinori
authors.initials: A
authors.lastname: Kogure
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Toda
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Toshihide
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D017668:Age of Onset; D001481:Basal Metabolism / Q000235:genetics*; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002151:Calorimetry; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D017931:DNA Primers; D050556:Fatty Acid-Binding Proteins; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D016133:Polymerase Chain Reaction; D013912:Threonine; D014781:Viscera
chemical_list: D002352:Carrier Proteins; D017931:DNA Primers; C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins; D013912:Threonine; D004247:DNA