title: Comparison of biochemical with radiological findings in renal osteodystrophy.
abstract: In a group of 121 adult patients with end-stage chronic renal failure who had been undergoing maintenance haemodialysis for up to 10 years a number of biochemical variables have been measured and related to a set of objective radiological changes in the same patients. The changes in plasma calcium, magnesium, phosphate, total protein, and albumin concentration did not distinguish the patients who were grouped on a radiological basis. Plasma alkaline phosphatase activity increased with the severity of the radiological findings but did not provide a sensitive discriminatory index between the different radiological groups. Plasma hydroxyproline concentration was found to be more sensitive than plasma alkaline phosphatase activity in detecting a radiological abnormality in some of the patients.
authors.affiliation: Department of Nephrology, Royal Free Hospital, London NW3 2XJ.
authors.forename: J F
authors.initials: JF
authors.lastname: Moorhead
authors.forename: Z
authors.initials: Z
authors.lastname: Varghese
authors.forename: G L
authors.initials: GL
authors.lastname: Tatler
authors.forename: R A
authors.initials: RA
authors.lastname: Baillod
authors.forename: M R
authors.initials: MR
authors.lastname: Wills
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology*; D002118:Calcium / Q000097:blood; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000097:blood; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood; D011859:Radiography; D006435:Renal Dialysis; D012680:Sensitivity and Specificity; D012709:Serum Albumin / Q000032:analysis; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D010710:Phosphates; D012709:Serum Albumin; D000469:Alkaline Phosphatase; D008274:Magnesium; D006909:Hydroxyproline; D002118:Calcium