Using computer based data acquisition and analysis system for nasal potential difference measurement in cystic fibrosis.
Nasal potential difference (PD) measurement has been used as a diagnostic test for cystic fibrosis (CF). It has been shown that large differences in reproducibility of nasal PD measurement can exist between different study sites. These differences reduce the validity of studies. In our study we tried to measure nasal PD values for a group of Turkish CF patients by using a computer based data acquisition system, which could eliminate the bias due to using different voltmeters. The CF group (n=40, mean age 9.3 years) value was -39.21+/-1.74 mV, and the control group (n=36, mean age 17.08 years) value was -18.24+/-1.48 mV (mean+/-SEM). Using the electronic data acquisition and analysis systems gave reliable results with high specificity (92%), sensitivity (79%), positive predictive value (95%) and negative predictive value (72%). Computer based data acquisition and analysis system provides suitable monitoring and continuous recording during measurements and facilitates repeat readings at the same distances along the nasal floor. Using electronic data acquisition may help to minimize the subjectivity in voltmeter measurements and hand analysis.
Ergönül
Zuhal
Z
Department of Physiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Balkanci
Z Dicle
ZD
Yilmaz
Gökhan
G
Kiper
Nural
N
Yalçin
Ebru
E
Doğru
Deniz
D
Ozçelik
Uğur
U
Göçmen
Ayhan
A
D000293:Adolescent; D000328:Adult; D001185:Artificial Intelligence; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology*; D012680:Sensitivity and Specificity; D013597:Systems Analysis