title: Functional long-term outcome of a free jejunal transplant reconstruction following chemoradiotherapy and radical resection for hypopharyngeal and proximal oesophageal carcinoma.
abstract: OBJECTIVE
  To evaluate the functional outcome of a reconstruction by a free vascularized jejunal transplant combined with a voice prosthesis after chemoradiotherapy and surgery for proximal oesophageal or hypopharyngeal cancer.
  
  
  METHODS
  Seven patients (6 men, mean age 52 years, range 28-70) with squamous cell cancer in the proximal oesophagus (n = 6) or the hypopharynx received preoperative chemoradiotherapy (40.8 Gy, cisplatinum and 5-FU) followed by a circumferential pharyngolaryngectomy and resection of the proximal oesophagus. A single-stage reconstruction was carried out with a free jejunal transplant using a microsurgical technique. A tracheojejunal puncture and insertion of a voice prosthesis (Provox I) was performed after 3 months in suitable cases.
  
  
  RESULTS
  All operations had a per- and postoperative uneventful course. Five patients were alive after a mean follow-up time of 5 years and 7 months after surgery (range 3 years 4 months to 7 years 10 months), while 2 patients died from metastases within 2 years after surgery. Postoperative examination showed histopathological down-staging in all cases. Relief of dysphagia was achieved in most cases. Good or average speech was recorded in 3 patients.
  
  
  CONCLUSIONS
  Reconstruction after radical resection for proximal oesophageal and hypopharyngeal cancer can be carried out with low mortality, acceptable morbidity and a promising functional outcome.
authors.affiliation: Department of Otorhinolaryngology, Sahlgrenska University Hospital, University of Göteborg, Göteborg, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Bergquist
authors.forename: Hasse
authors.initials: H
authors.lastname: Ejnell
authors.forename: Ingemar
authors.initials: I
authors.lastname: Fogdestam
authors.forename: Hans
authors.initials: H
authors.lastname: Mark
authors.forename: Claes
authors.initials: C
authors.lastname: Mercke
authors.forename: Lars
authors.initials: L
authors.lastname: Lundell
authors.forename: Magnus
authors.initials: M
authors.lastname: Ruth
mesh_terms: D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D007583:Jejunum / Q000601:surgery*; D007831:Larynx, Artificial; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D019651:Plastic Surgery Procedures; D020127:Recovery of Function; D016896:Treatment Outcome