title: Synthesis and pharmacological activity of 4-(4'-(chlorophenyl)-4-hydroxypiperidine) derivatives.
abstract: A new series of 4-(4'-chlorophenyl)-4-hydroxypiperidine derivatives (2-5), substituted at nitrogen, were synthesized and tested as potential analgesic compounds as well as evaluated for their effect on hypotensive activity. Results showed that all the derivatives exhibit significant analgesic activity in male Wistar rats at a dose of 50 mg/kg of body weight after intramuscular injection, when tested by thermal stimuli (tail flick test). Pethidine was used as reference drug. Compounds 2, 3 and 5 produced reduction in blood pressure in normotensive rat.
authors.affiliation: HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi, Pakistan. hassaan2@super.net.pk
authors.forename: Zafar Saeed
authors.initials: ZS
authors.lastname: Saify
authors.forename: Nousheen
authors.initials: N
authors.lastname: Mushtaq
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: Syed Tasadaque Ali
authors.initials: ST
authors.lastname: Shah
authors.forename: Raid Jamil
authors.initials: RJ
authors.lastname: Abdel-Jalil
authors.forename: Miriam
authors.initials: M
authors.lastname: Fecker
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Voelter
mesh_terms: D000818:Animals; D008297:Male; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010880:Piperidines