Heterogeneity of expression of IgA receptors by human, mouse, and rat eosinophils.
IgA is the most abundant class of Abs at mucosal surfaces where eosinophils carry out many of their effector functions. Most of the known IgA-mediated functions require interactions with IgA receptors, six of which have been identified in humans. These include the IgA FcR FcalphaRI/CD89 and the receptor for the secretory component, already identified on human eosinophils, the polymeric IgR, the Fcalpha/muR, asialoglycoprotein (ASGP)-R, and transferrin (Tf)R/CD71. In rodents, the existence of IgA receptors on mouse and rat eosinophils remains unclear. We have compared the expression and function of IgA receptors by human, rat, and mouse eosinophils. Our results show that human eosinophils express functional polymeric IgR, ASGP-R, and TfR, in addition to CD89 and the receptor for the secretory component, and that IgA receptors are expressed by rodent eosinophils. Indeed, mouse eosinophils expressed only TfR, whereas rat eosinophils expressed ASGP-R and CD89 mRNA. These results provide a molecular basis for the differences observed between human, rat, and mouse regarding IgA-mediated immunity.
Decot
Véronique
V
Institut National de la Santé et de la Recherche Médicale Unité 547-Institut Fédératif de Recherche 17, Institut Pasteur de Lille, France.
Woerly
Gaëtane
G
Loyens
Marc
M
Loiseau
Sylvie
S
Quatannens
Brigitte
B
Capron
Monique
M
Dombrowicz
David
D
D000818:Animals; D037263:Asialoglycoprotein Receptor / Q000096:biosynthesis / Q000097:blood; D002478:Cells, Cultured; D004804:Eosinophils / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D011485:Protein Binding / Q000276:immunology; D051381:Rats; D011914:Rats, Inbred BN; D011961:Receptors, Fc / Q000096:biosynthesis* / Q000097:blood; D019056:Receptors, Polymeric Immunoglobulin / Q000096:biosynthesis / Q000097:blood; D011990:Receptors, Transferrin / Q000096:biosynthesis / Q000097:blood
D037263:Asialoglycoprotein Receptor; C045281:IgA receptor; D007070:Immunoglobulin A; D011961:Receptors, Fc; D019056:Receptors, Polymeric Immunoglobulin; D011990:Receptors, Transferrin