Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients.
We prospectively examined brachial artery endothelial function using vascular ultrasound in 41 obese subjects treated with medical or surgical (gastric bypass) weight loss interventions. Surgical intervention produced greater weight loss and more pronounced improvement in endothelial function than medical treatment alone. Improved endothelial function with weight loss correlated strongly with fasting glucose but not with alteration in blood pressure, lipids, degree of weight loss, or plasma resistin concentrations. These data demonstrate that weight loss in markedly obese patients improves endothelial function and glycemic control that may represent important mechanisms of the cardiovascular benefit associated with weight reduction.
Gokce
Noyan
N
Evans Department of Medicine, Cardiology and Endocrinology Sections, Boston University School of Medicine, Boston, MA, USA. Noyan.Gokce@bmc.org
Vita
Joseph A
JA
McDonnell
Marie
M
Forse
Armour R
AR
Istfan
Nawfal
N
Stoeckl
Maria
M
Lipinska
Izabella
I
Keaney
John F
JF
Apovian
Caroline M
CM
D000328:Adult; D001786:Blood Glucose; D001916:Brachial Artery / Q000187:drug effects / Q000502:physiology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology; D009765:Obesity / Q000503:physiopathology* / Q000601:surgery*; D011446:Prospective Studies; D011673:Pulsatile Flow; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D015431:Weight Loss
D001786:Blood Glucose; D005996:Nitroglycerin