title: Metabolic effects of ghrelin and its potential implications in uremia.
abstract: Ghrelin is a recently described hormone secreted by the stomach. Ghrelin administration in ad-libitum-fed rodents was shown to increase appetite as well as body weight and body fat content, showing metabolic effects of ghrelin in vivo and suggesting its involvement in the pathogenesis of obesity. However, plasma ghrelin concentration was shown to be inversely correlated with body weight and body fat in people and rodents. Increased plasma ghrelin concentration was also reported during diet-induced weight loss and in malnourished states. These findings suggest that circulating ghrelin is regulated by nutritional state and body fat with a feedback mechanism opposing changes in body composition, with a potential key adaptive role during calorie restriction. Plasma ghrelin concentration was shown to be increased in advanced renal failure and hemodialysis patients. The known metabolic effects of ghrelin and the potential implications of hyperghrelinemia in kidney disease will be discussed in this article.
authors.affiliation: Clinica Medica, DSCMT, University of Trieste, Trieste, Italy. barazzon@units.it <barazzon@units.it>
authors.forename: Rocco
authors.initials: R
authors.lastname: Barazzoni
authors.forename: Michela
authors.initials: M
authors.lastname: Zanetti
authors.forename: Gianni
authors.initials: G
authors.lastname: Biolo
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Guarnieri
mesh_terms: D000273:Adipose Tissue; D000818:Animals; D001066:Appetite; D001823:Body Composition / Q000502:physiology; D004435:Eating; D025461:Feedback, Physiological; D054439:Ghrelin; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism; D015227:Lipid Peroxidation; D036361:Peptide Hormones / Q000097:blood / Q000502:physiology*; D014511:Uremia / Q000378:metabolism
chemical_list: D054439:Ghrelin; D036361:Peptide Hormones