An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia.
Dysfunctions of glutamatergic and GABAergic neurotransmission are two important hypotheses for the pathogenesis of schizophrenia. Thus, genes in the pathway are candidates for schizophrenia susceptibility. Phosphate-activated glutaminase (GLS), glutamine synthetase (GLUL), glutamic acid decarboxylase (GAD), GABA transaminase (ABAT) and succinic semialdehyde dehydrogenase (ALDH5A1) are five primary enzymes in glutamate and GABA synthetic and degradative pathway. In order to investigate the possible involvement of these genes in the development of paranoid schizophrenia, we genotyped 80 paranoid schizophrenics from northern China and 108 matched controls by polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP) methods or directly sequencing of PCR product. Seven SNPs were found to be polymorphic in the population investigated. No significant differences in the genotype distributions or allele frequencies between patients and controls were found. Therefore, we conclude the polymorphisms studied in the five genes do not play major roles in pathogenesis of paranoid schizophrenia in the population investigated.
Zhang
Boyu
B
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 5, Dong Dan San Tiao, Beijing 100005, China.
Yuan
Yanbo
Y
Jia
Yanbin
Y
Yu
Xin
X
Xu
Qi
Q
Shen
Yucun
Y
Shen
Yan
Y
D000328:Adult; D044466:Asian People; D004798:Enzymes / Q000235:genetics*; D005260:Female; D018698:Glutamic Acid / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012563:Schizophrenia, Paranoid / Q000201:enzymology* / Q000235:genetics* / Q000523:psychology; D015398:Signal Transduction / Q000235:genetics; D005680:gamma-Aminobutyric Acid / Q000235:genetics*
D004798:Enzymes; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid