Neurogenic aspects of inflammation.
The relationship between the inflammatory process and the nervous system is twofold. The nervous system is activated by inflammation which causes inflammatory pain and impaired motor function. Conversely, the nervous system acts back on the peripheral process. This is achieved by output systems at different levels, including primary afferent fibers (neurogenic inflammation), spinal cord (reflexes), and the brain (eg, neuroendocrine functions). This article first addresses the activation of the nociceptive system by inflammation; the second part describes the effects of the nervous system on inflamed tissue.
Schaible
Hans-Georg
HG
Department of Physiology, University of Jena, Am Teichgraben 8, 07740 Jena, Germany. Hans-Georg.Schaible@mti.uni-jena.de
Del Rosso
Angela
A
Matucci-Cerinic
Marco
M
D000818:Animals; D001168:Arthritis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D002490:Central Nervous System / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D009619:Nociceptors / Q000503:physiopathology*; D010447:Peptide Hydrolases / Q000502:physiology
D009479:Neuropeptides; D010447:Peptide Hydrolases