title: Antigen-specific beta-chemokine production and CD8 T-cell noncytotoxic antiviral activity in HIV-2-infected individuals.
abstract: Human immunodeficiency virus-2 (HIV-2) is less pathogenic than HIV-1, and the disease progression in HIV-2-infected individuals seems to be similar to that seen in HIV-1-infected long-term nonprogressors. Cell-mediated immune responses and the production of noncytotoxic CD8+ T-cell antiviral factors (CAF) and beta-chemokines have been correlated to protection against HIV-1 and associated with asymptomatic infection and slower disease progression. We investigated the antigen-induced beta-chemokine production in HIV-2-infected patients living in Sweden and in Guinea-Bissau. We also compared in vitro CD8+ T-cell-mediated noncytotoxic antiviral activity against beta-chemokine-sensitive R5 virus (HIV-1Bal) and beta-chemokine-insensitive X4 virus (HIV-1IIIB) in HIV-2-infected patients with that in HIV-1-infected patients. HIV-2-specific beta-chemokine production was demonstrated in a majority of the HIV-2-infected subjects. CD8+ T cells of both HIV-1 and HIV-2-infected individuals suppressed R5 virus replication in vitro in a similar manner, while the inhibition of X4 virus replication seemed to be more frequent and of a higher magnitude among HIV-2-infected patients compared to HIV-1-infected subjects. Taken together, our results indicate that the production of CD8+ T-cell noncytotoxic antiviral factors may contribute to the low transmission of the virus and slower disease progression in HIV-2-infected patients.
authors.affiliation: Tumorbiology Center, Karolinska Institute, Solna, Sweden. raija.ahmed@smi.ki.se
authors.forename: R K S
authors.initials: RK
authors.lastname: Ahmed
authors.forename: H
authors.initials: H
authors.lastname: Norrgren
authors.forename: Z
authors.initials: Z
authors.lastname: da Silva
authors.forename: A
authors.initials: A
authors.lastname: Blaxhult
authors.forename: E-L
authors.initials: EL
authors.lastname: Fredriksson
authors.forename: G
authors.initials: G
authors.lastname: Biberfeld
authors.forename: S
authors.initials: S
authors.lastname: Andersson
authors.forename: R
authors.initials: R
authors.lastname: Thorstensson
mesh_terms: D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000096:biosynthesis; D019742:Chemokines, CC / Q000096:biosynthesis*; D005260:Female; D006169:Guinea-Bissau; D015488:HIV Antigens; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D015498:HIV-2 / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D019402:Macrophage Inflammatory Proteins / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D013548:Sweden; D014779:Virus Replication
chemical_list: D054407:Chemokine CCL4; D018946:Chemokine CCL5; D019742:Chemokines, CC; D015488:HIV Antigens; D019402:Macrophage Inflammatory Proteins