Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activity.
Two new furo-1,2-naphthoquinones, crataequinones A (1) and B (2), were isolated from the fruits of Crataegus pinnatifida. The structures of two new compounds were determined as 11,12-dimethoxy-3,4-furo-1,2-naphthoquinone (1) and 11,12-dimethoxy-5-hydroxy-3,4-furo-1,2-naphthoquinone (2) by spectroscopic analysis. The two compounds 1 and 2 showed significant inhibitory activity with IC50 values of 33 and 90 microM, respectively, against the expression of intercellular adhesion molecule-1 (ICAM-1).
Min
Byung-Sun
BS
Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
Huong
Ha-Thi-Thanh
HT
Kim
Jung-Hee
JH
Jun
Hyun-Ju
HJ
Na
Min-Kyun
MK
Nam
Nguyen-Hai
NH
Lee
Hyeong-Kyu
HK
Bae
KiHwan
K
Kang
Sam-Sik
SS
D000818:Animals; D000911:Antibodies, Monoclonal; D027825:Crataegus; D005638:Fruit; D006801:Humans; D020128:Inhibitory Concentration 50; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects*; D051379:Mice; D009285:Naphthoquinones / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000911:Antibodies, Monoclonal; D009285:Naphthoquinones; D010936:Plant Extracts; D018799:Intercellular Adhesion Molecule-1