Vanishing pancreatic grafts.
Comparison of pancreaticoduodenal transplants (PDT) and duct-ligated pancreas transplant (DLPT) were performed using syngeneic and allogeneic studies in rats. Both DLPT and PDT allogeneic grafts showed mild rejection. DLPT groups showed disorganized pathology and acini replaced by fat. Eventually, massive fibrosis was seen in the Islets of Langerhans, as well as rejection cellular infiltrates. In both PDT groups, normal histology was observed in the same period. Thus the effect of duct occlusion is highly detrimental for the grafts.
Pivetti
Christopher
C
San Diego Microsurgical Institute, San Diego, CA 92103, USA.
Hong
In Chul
IC
Yoo
Chang H
CH
Lee
Sun
S
Kim
Kenny
K
Emmanuel
Gregory
G
Kim
Jason
J
Chung
Romy
R
Niewiadomski
Slawomir
S
Wolf
Paul
P
Gittes
R F
RF
D000818:Animals; D006084:Graft Rejection / Q000473:pathology; D008026:Ligation / Q000009:adverse effects; D010179:Pancreas / Q000473:pathology*; D016035:Pancreas Transplantation / Q000009:adverse effects*; D010183:Pancreatic Ducts / Q000601:surgery; D011184:Postoperative Period; D051381:Rats; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic