Multipolymer solution-phase reactions: application to the Mitsunobu reaction.
The realization of the first polymer-on-polymer Mitsunobu reaction, in which a polymeric phosphine is used simultaneously with a polymeric azodicarboxylate, is reported. This strategy employs the use of soluble oligomers generated from ring-opening methathesis polymerization. 31P NMR analysis revealed that the two polymers were interacting to generate the Mitsunobu products. Application to several substrates, as well as comparison experiments with other polymeric reagents, is described.
Harned
Andrew M
AM
Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA.
He
Helen Song
HS
Toy
Patrick H
PH
Flynn
Daniel L
DL
Hanson
Paul R
PR
D001685:Biological Factors / Q000138:chemical synthesis; D002625:Chemistry, Organic / Q000379:methods*; D004952:Esters / Q000138:chemical synthesis*; D011108:Polymers / Q000737:chemistry*; D012996:Solutions
D001685:Biological Factors; D004952:Esters; D011108:Polymers; D012996:Solutions