title: [Corneal transplantation--immunological mechanisms of rejection episode].
abstract: Organ transplantation including cornea is often only the one method of treatment in case of their irreversible destruction. The genetic difference between donor and graft recipient makes the immunological system recognizes foreign antigens and triggers off a rejection episode. This article reviews corneal graft rejection immunology and indicates possible future options for the clinical evaluation of more specific therapeutic agents that modulate the immunological mechanisms of allograft rejection. It discusses also the role of HLA matching in the survival of corneal grafts especially in "high risk" eyes.
authors.affiliation: Z Katedry i Kliniki Okulistyki Slaskiej Akademii Medycznej w Katowicach.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Cwalina
authors.forename: Ewa
authors.initials: E
authors.lastname: Mrukwa-Kominek
mesh_terms: D015703:Antigens, CD / Q000276:immunology; D016039:Corneal Transplantation / Q000379:methods*; D006084:Graft Rejection / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D011183:Postoperative Complications
chemical_list: D015703:Antigens, CD; D006684:HLA-DR Antigens