Influence of diet containing lyophilized Enterococcus faecium M-74 with organic selenium on tumor incidence in Apc1638N mice.
The aim of the present study was to test the effect of long-term application of diet containing Enterococcus faecium M-74 with organic selenium on tumor induction in transgenic mice carrying mutation in Apc gene. Heterozygosity for the Apc1638N mutation in mice causes development of small intestine and gastric tumors. Feeding of Apc1638N transgenic mice with enriched diet with probiotic components during 8 months have shown a minor therapeutic effect on the clinical manifestations in small intestine in comparison with control group.
Hlubinová
K
K
Cancer Research Institute, Slovak Academy of Sciences, 833 91 Bratislava, Slovak Republic. exonhlub@savba.sk
Rychlý
B
B
Altanerová
V
V
Ebringer
L
L
Altaner
C
C
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D000818:Animals; D001483:Base Sequence; D004032:Diet; D016984:Enterococcus faecium; D016368:Frameshift Mutation; D005612:Freeze Drying; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D017491:Genes, APC; D015316:Genetic Therapy; D005838:Genotype; D006720:Homozygote; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D016133:Polymerase Chain Reaction; D019936:Probiotics; D012643:Selenium / Q000627:therapeutic use*
D012643:Selenium