title: Expression of Notch in a case of osteosarcoma of the maxilla.
abstract: In this immunohistochemical examination, the expression of Notch1 peptide was detected in neoplastic cells in a case of osteosarcoma of the maxilla of a 31-year-old Indonesian male patient. Notch1 peptide appeared in the cytoplasm of neoplastic cells of comparatively well-differentiated areas of the osteosarcoma, an osteoblastic area containing osteoid and/or immature bone tissues. The results suggest that Notch1 is closely related to cytological differentiation or acquisition of cytological characteristics in neoplastic cells of osteosarcoma.
authors.affiliation: Hard Tissue Pathology Unit, Department of Hard Tissue Research, Matsumoto Dental University Graduate School of Oral Medicine, 1780 Hirooka-Gobara, Shiojiri 399-0781, Japan. kawakami@po.mdu.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kawakami
authors.forename: C H
authors.initials: CH
authors.lastname: Siar
authors.forename: K H
authors.initials: KH
authors.lastname: Ng
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: N
authors.initials: N
authors.lastname: Okafuji
authors.forename: S
authors.initials: S
authors.lastname: Kurihara
authors.forename: H
authors.initials: H
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Tsujigiwa
authors.forename: H
authors.initials: H
authors.lastname: Nagatsuka
authors.forename: N
authors.initials: N
authors.lastname: Nagai
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008441:Maxillary Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D012516:Osteosarcoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D051881:Receptor, Notch1; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C497761:NOTCH1 protein, human; D051881:Receptor, Notch1; D011956:Receptors, Cell Surface; D014157:Transcription Factors