title: Enantioseparation of flurbiprofen and ketoprofen in patches and in urine excretions by achiral gas chromatography.
abstract: The enantiomeric composition tests on flurbiprofen and ketoprofen present in patch products and in urine excretions following patch applications were performed as diastereomeric (R)-(+)-1-phenylethylamides by achiral gas chromatography and by gas chromatography-mass spectrometry in selected ion monitoring mode. The method for determination of (R)- and (S)-enantiomers in the range from 0.1 to 5.0 microg was linear (r > or = 0.9996) with acceptable precision (% RSD < or = 5.2) and accuracy (% RE = 0.6 approximately -2.4). The enantiomeric compositions of flurbiprofen in one patch product and of ketoprofen in five different products were identified to be racemic with relatively good precision (< or = 6.4%). The urinary excretion level of (R)-flurbiprofen was two times higher than its antipode, while the comparable excretion levels of (R)- and (S)-enantiomers for ketoprofen were observed.
authors.affiliation: College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Man-Jeong
authors.initials: MJ
authors.lastname: Paik
authors.forename: Duc-Toan
authors.initials: DT
authors.lastname: Nguyen
authors.forename: Kyoung-Rae
authors.initials: KR
authors.lastname: Kim
mesh_terms: D002849:Chromatography, Gas / Q000379:methods; D005480:Flurbiprofen / Q000737:chemistry* / Q000652:urine*; D006801:Humans; D007660:Ketoprofen / Q000737:chemistry* / Q000652:urine*; D008297:Male; D015203:Reproducibility of Results; D013237:Stereoisomerism
chemical_list: D005480:Flurbiprofen; D007660:Ketoprofen