[Relationship of endothelin-1 (ET-1) TaqI and tumor necrosis factor (TNF) a gene polymorphism with portal hypertension in liver cirrhosis].
OBJECTIVE
To study whether liver cirrhosis and portal hypertension are associated with ET-1 TaqI polymorphism and TNFa promoter-308G to A polymorphism.


METHODS
A case control study of 106 patients with liver cirrhosis following HBV C infection was performed in comparison with 108 controls by PCR-RFLP.


RESULTS
The frequency of C allele and CC+TC genotype in TaqI polymorphism of ET-1 gene in the portal hypertension group (LC+) was significantly higher than that in the healthy controls, and the frequency of TNF2/1 genotype in TNFa promoter -308 G to A polymorphism in LC+ group was significantly higher than that in the control group. The results by stratification analysis showed that TCF2 genotype frequency was higher in the LC+ group than in the control group. ET-1 TaqI polymorphism and TNFa polymorphism were risk factors for the occurrence of portal hypertension by Logistic regression analysis.


CONCLUSIONS
ET-1 TaqI polymorphism and TNFa polymorphism are associated with portal hypertension, and are new risk factors for the occurrence of portal hypertension. TCF2 genotype may be a susceptible gene of portal hypertension.
Cheng
Yuan-qiao
YQ
Department of Infectious Diseases, Dongguan People's Hospital, Guangdong Province, Dongguan 523018, China.
Wang
Wen-qi
WQ
Lin
Ju-sheng
JS
Xiong
Ping
P
D000328:Adult; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D019694:Hepatitis B, Chronic / Q000150:complications / Q000235:genetics; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology / Q000235:genetics*; D008103:Liver Cirrhosis / Q000150:complications / Q000235:genetics* / Q000821:virology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic / Q000235:genetics; D019914:Taq Polymerase / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D019332:Endothelin-1; D014409:Tumor Necrosis Factor-alpha; D019914:Taq Polymerase