Importance of measuring products of non-enzymatic glycation of proteins.
Non-enzymatic glycation products are a complex and heterogeneous group of compounds which accumulate in plasma and tissues in diabetes and renal failure. There is emerging evidence that these compounds may play a role in the pathogenesis of chronic complications associated with diabetes and renal failure. So measurement of the products of non-enzymatic glycation has a twofold meaning: on one hand, measurement of early glycation products can estimate the extent of exposure to glucose and the subject's previous metabolic control; on the other hand, measurement of intermediate and late products of the glycation reaction is a precious instrument in verifying the relationship between glycation products and tissue modifications. This review summarizes current knowledge about the diagnostic utility of measuring non-enzymatic glycation products.
Lapolla
Annunziata
A
Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Malattie del Metabolismo, Università di Padova, Padova, Italy. annunziata.lapolla@unipd.it
Traldi
Pietro
P
Fedele
Domenico
D
D006442:Glycated Hemoglobin / Q000032:analysis; D017127:Glycation End Products, Advanced / Q000032:analysis* / Q000737:chemistry; D006023:Glycoproteins / Q000097:blood; D006031:Glycosylation; D006801:Humans; D051437:Renal Insufficiency / Q000097:blood
D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D006023:Glycoproteins