title: Harnessing HIV for therapy, basic research and biotechnology.
abstract: First described about a decade ago, lentiviral vectors ('lentivectors') have emerged as potent and versatile tools of gene transfer for basic and applied research and offer exciting perspectives for the field of gene therapy. In the clinic, HIV-based vectors are showing particular promise for delivering therapeutic genes to hematopoietic stem cells (HSCs) and terminally differentiated targets in the central nervous system (CNS). Their flexible design facilitates the accommodation of sophisticated elements of control for the precise tuning of transgene expression. The delivery of small interfering RNAs (siRNAs) and genomic or cDNA libraries and the creation of transgenic animals are the most recent and exciting applications of HIV-based vectors that will help to tackle fundamental issues across wide areas of biology.
authors.affiliation: Frontiers in Genetics, National Center for Competence in Research, School of Life Sciences, Swiss Federal Institute of Technology, Laussane, Switzerland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Wiznerowicz
authors.forename: Didier
authors.initials: D
authors.lastname: Trono
mesh_terms: D000818:Animals; D002490:Central Nervous System; D015870:Gene Expression; D018390:Gene Targeting; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D015497:HIV-1; D006801:Humans; D034622:RNA Interference; D013234:Stem Cells