title: Simultaneous symptomatic Rathke's cleft cyst and GH secreting pituitary adenoma: a case report.
abstract: A case of symptomatic Rathke's cleft cyst and growth hormone (GH) secreting pituitary adenoma is described. A patient presented with a visual field deficit and a brain magnetic resonance imaging (MRI) study demonstrated compression of the optic chiasm by a large suprasellar cyst and a small lesion in the sellar consistent with a microadenoma. Preoperative clinical evaluation revealed mild acromegalic features, glucose intolerance, hypertension, hypercholesterolemia, and carpel tunnel syndrome, and blood testing confirmed an elevated insulin-like growth factor-1 (IGF-1). A modified transsphenoidal skull based approach was performed for selective transsphenoidal adenomectomy and decompression of the surprasellar cyst. The patient had an uneventful postoperative course with resolution of the visual field deficits and dysmenorrhea. Endocrine testing at two-month post procedure were normal. While there have been a small number of cases reported of concomitant pituitary adenomas and Rathke's cleft cysts, there is no report known to these authors of coexisting symptomatic lesions.
authors.affiliation: Department of Neurological Surgery, UC Davis Medical Center, Sacramento, CA, USA.
authors.forename: Lucas J
authors.initials: LJ
authors.lastname: Bader
authors.forename: Kawanaa D
authors.initials: KD
authors.lastname: Carter
authors.forename: Richard E
authors.initials: RE
authors.lastname: Latchaw
authors.forename: William G
authors.initials: WG
authors.lastname: Ellis
authors.forename: Jason A
authors.initials: JA
authors.lastname: Wexler
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Watson
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000378:metabolism* / Q000601:surgery; D020863:Central Nervous System Cysts / Q000150:complications* / Q000601:surgery; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications* / Q000378:metabolism* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone