title: A diketopiperazine dimer from a marine-derived isolate of Aspergillus niger.
abstract: The new diketopiperazine dimer 1, as well as the known compounds TMC-256A1 (2), TMC-256C1 (3), and demethylkotanin (4), were isolated from a culture of Aspergillus niger. The gross structure of 1 was determined by 2D NMR studies and comparison with literature data, and the absolute stereochemistry was elucidated by chiral HPLC analysis of the hydrolysis products.
authors.affiliation: Cerylid Biosciences, 576 Swan Street, Richmond, Victoria, 3121, Australia.
authors.forename: Simon P B
authors.initials: SP
authors.lastname: Ovenden
authors.forename: Gian
authors.initials: G
authors.lastname: Sberna
authors.forename: R Murray
authors.initials: RM
authors.lastname: Tait
authors.forename: Howard G
authors.initials: HG
authors.lastname: Wildman
authors.forename: Rupal
authors.initials: R
authors.lastname: Patel
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Kevin
authors.initials: K
authors.lastname: Steffy
authors.forename: Natalie
authors.initials: N
authors.lastname: Nguyen
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Meurer-Grimes
mesh_terms: D001234:Aspergillus niger / Q000737:chemistry*; D001315:Australia; D002851:Chromatography, High Pressure Liquid; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification; D054659:Diketopiperazines; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010879:Piperazines / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D002867:Chromones; D003374:Coumarins; D054659:Diketopiperazines; D010879:Piperazines; C467209:TMC 256A1; C467210:TMC 256C1; C497294:demethylkotanin