title: Phomapyrones from blackleg causing phytopathogenic fungi: isolation, structure determination, biosyntheses and biological activity.
abstract: The isolation and structure determination of phomapyrones D-G, three 2-pyrones and a coumarin, from a group of isolates of the fungal pathogen Leptosphaeria maculans (Desm.) Ces. et de Not., asexual stage Phoma lingam (Tode ex Fr.) Desm, is reported. As well, phomenin B, infectopyrone, and polanrazines B and C were also obtained for the first time from these isolates. In addition, based on results of incorporations of 13C-labeled acetate and malonate, and deuterated methionine, a polyketide pathway is proposed for the biosyntheses of phomapyrones.
authors.affiliation: Department of Chemistry, University of Saskatchewan, 110 Science Place, Sask., Canada SK S7N 5C9. s.pedras@usask.ca
authors.forename: M Soledade C
authors.initials: MS
authors.lastname: Pedras
authors.forename: Paulos B
authors.initials: PB
authors.lastname: Chumala
mesh_terms: D001203:Ascomycota / Q000737:chemistry* / Q000378:metabolism; D029688:Brassica napus / Q000382:microbiology; D015394:Molecular Structure; D009149:Mustard Plant / Q000382:microbiology; D010935:Plant Diseases / Q000382:microbiology; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D031226:Sinapis / Q000382:microbiology
chemical_list: D011753:Pyrones