title: In vitro efficacy of new antiprotozoals against Philasterides dicentrarchi (Ciliophora, Scuticociliatida).
abstract: Philasterides dicentrarchi is a histiophagous ciliate that causes severe losses in turbot and sea bass farming. This study investigated the in vitro efficacy against P. dicentrarchi of 85 newly synthesized compounds and 12 commercial compounds, of which 2 are fluoroquinolones (norfloxacine and lomefloxacine) with known antibacterial activity. Seventeen of the newly synthesized compounds (2 naphthyridines, 2 pyridothienodiazines and 13 pyridothienotriazines) and the fluoroquinolone norfloxacin showed good activity. The most promising compound was the pyridothienotriazine 12k, with activity similar to that of the salicylanilides niclosamide and oxiclozanide (MLC 0.8 mg l(-1) in PBS, 1.5 mg l(-1) in seawater; MLC = minimum 24 h lethal concentration).
authors.affiliation: Laboratorio de Parasitología, Instituto de Investigación y Análisis Alimentarios, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Paramá
authors.forename: R
authors.initials: R
authors.lastname: Iglesias
authors.forename: F
authors.initials: F
authors.lastname: Alvarez
authors.forename: J M
authors.initials: JM
authors.lastname: Leiro
authors.forename: J M
authors.initials: JM
authors.lastname: Quintela
authors.forename: C
authors.initials: C
authors.lastname: Peinador
authors.forename: L
authors.initials: L
authors.lastname: González
authors.forename: R
authors.initials: R
authors.lastname: Riguera
authors.forename: M L
authors.initials: ML
authors.lastname: Sanmartín
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D017756:Aquaculture / Q000379:methods; D016770:Ciliophora Infections / Q000188:drug therapy / Q000662:veterinary*; D004305:Dose-Response Relationship, Drug; D005393:Fish Diseases / Q000188:drug therapy* / Q000469:parasitology*; D005399:Fishes; D006652:Histological Techniques / Q000662:veterinary; D009287:Naphthyridines / Q000627:therapeutic use; D016802:Oligohymenophorea
chemical_list: D000981:Antiprotozoal Agents; D009287:Naphthyridines