Metabolism of macromolecules in tissue.
Hyaluronan (HA) plays an important role in maintaining tissue integrity, as well as in facilitating the migration of cells during inflammation, wound repair, and embryonic development. By comparison with other macromolecules of the extracellular matrix, HA undergoes rapid turnover. Most of its degradation does not occur locally, but within distant lymph nodes. During this process, tissue HA enters the afferent lymphatics and is transported with the lymph to the draining lymph nodes. Because of its unique catabolic pathway, the fate of HA is an interesting subject for investigation, particularly in pathological states of lymphangiodysplasia or lymphatic damage.
Liu
Ningfei
N
Department of Plastic Surgery, Ninth People's Hospital, Shanghai Second Medical University, PR China. liun2002@yahoo.com
D000818:Animals; D002465:Cell Movement; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D007249:Inflammation; D008196:Lymph / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology; D008208:Lymphatic System / Q000502:physiology; D008209:Lymphedema / Q000473:pathology; D046911:Macromolecular Substances / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D033921:Vesicular Transport Proteins; D014945:Wound Healing
D006023:Glycoproteins; C119248:LYVE1 protein, human; D046911:Macromolecular Substances; D033921:Vesicular Transport Proteins; D006820:Hyaluronic Acid