title: Selegiline in comparison with methylphenidate in attention deficit hyperactivity disorder children and adolescents in a double-blind, randomized clinical trial.
abstract: OBJECTIVE
  The aim of this study was to examine the selegiline treatment compared to methylphenidate (MPH) in children and adolescents with attention deficit hyperactivity disorder (ADHD).
  
  
  METHODS
  Forty subjects, aged 6-15 years, boys and girls, who were diagnosed as having ADHD, using the criteria of the Diagnostic and Statistical Manual of Mental Disorders- Fourth Edition (DSM-IV), were randomly assigned to receive either selegiline or MPH for 60 days. Treatment outcomes were assessed using the Attention Deficit Hyperactivity Scale (ADHS) administered at baseline and on days 14, 28, 42, and 60 following the commencement of treatment. Side effects were also rated.
  
  
  RESULTS
  There were no significant differences between sex, age, weight, and ethnicity of participants in the 2 groups. Both groups showed a significant improvement over the 60 days of treatment resulting from the teachers' and parents' ADHS scores across the treatment.
  
  
  CONCLUSIONS
  Following the trial, MPH did not effect greater mean improvement as a result of the parents' or teachers' ADHS scores than selegiline. Thus, selegiline appears to be effective and well tolerated for ADHD in children and adolescents.
authors.affiliation: Department of Psychiatry, Tehran University of Medical Sciences, Psychiatry and Clinical Psychology Research Center, Roozbeh Hospital, Tehran, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Mohammadi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Ghanizadeh
authors.forename: Javad
authors.initials: J
authors.lastname: Alaghband-Rad
authors.forename: Mahdi
authors.initials: M
authors.lastname: Tehranidoost
authors.forename: Bita
authors.initials: B
authors.lastname: Mesgarpour
authors.forename: Hamid
authors.initials: H
authors.lastname: Soori
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000139:chemically induced; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects / Q000627:therapeutic use*; D012642:Selegiline / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D008774:Methylphenidate; D012642:Selegiline