title: Neurogenic aspects of inflammation.
abstract: The relationship between the inflammatory process and the nervous system is twofold. The nervous system is activated by inflammation which causes inflammatory pain and impaired motor function. Conversely, the nervous system acts back on the peripheral process. This is achieved by output systems at different levels, including primary afferent fibers (neurogenic inflammation), spinal cord (reflexes), and the brain (eg, neuroendocrine functions). This article first addresses the activation of the nociceptive system by inflammation; the second part describes the effects of the nervous system on inflamed tissue.
authors.affiliation: Department of Physiology, University of Jena, Am Teichgraben 8, 07740 Jena, Germany. Hans-Georg.Schaible@mti.uni-jena.de
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Schaible
authors.forename: Angela
authors.initials: A
authors.lastname: Del Rosso
authors.forename: Marco
authors.initials: M
authors.lastname: Matucci-Cerinic
mesh_terms: D000818:Animals; D001168:Arthritis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D002490:Central Nervous System / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D009619:Nociceptors / Q000503:physiopathology*; D010447:Peptide Hydrolases / Q000502:physiology
chemical_list: D009479:Neuropeptides; D010447:Peptide Hydrolases