title: Cytotoxic coumarins from the root of Angelica dahurica.
abstract: Ten coumarins were isolated from the root of Angelica dahurica by repeated silica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, oxypeucedanin hydrate acetonide (7) was isolated for the first time from this plant. Cytotoxicity of coumarins isolated were determined in vitro against L1210, HL-60, K562, and B16F10 tumor cell lines by MTT method. Pangelin (5) and oxypeucedanin hydrate acetonide (7) showed a potent cytotoxic activity with the IC50 values of 8.6 to 14.6 microg/mL against four kinds of tumor cell lines. Other compounds showed the moderate cytotoxic activity or no activity against the tumor cell lines.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
authors.forename: Pham Ngoc
authors.initials: PN
authors.lastname: Thanh
authors.forename: WenYi
authors.initials: W
authors.lastname: Jin
authors.forename: GyuYong
authors.initials: G
authors.lastname: Song
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
mesh_terms: D029969:Angelica / Q000633:toxicity*; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018517:Plant Roots / Q000633:toxicity
chemical_list: D003374:Coumarins; D010936:Plant Extracts