title: [Avascular osteonecrosis of femoral head and neck in an AIDS patient].
abstract: Avascular osteonecrosis (AON) has increased in the last few years in patients infected with the human immunodeficiency virus type-1 (HIV-1). The most commonly affected bone is the femoral head and neck. Frequently these bilateral and clinical findings include moderate to severe pain and functional impotence of the affected joints. The etiology is multifactorial and highly active antiretroviral therapy (HAART) with protease inhibitors (PI) is probably related to its development. In the evolution, a total hip replacement may be needed. We present an hemophilic patient with AIDS, who developed a bilateral AON of the femoral head and neck during HAART.
authors.affiliation: Fundación Argentina de la Hemofilia, Buenos Aires, Argentina. mfioti@intramed.net.ar
authors.forename: Maria F
authors.initials: MF
authors.lastname: Villafañe
authors.forename: Marcelo E
authors.initials: ME
authors.lastname: Corti
authors.forename: Miguel
authors.initials: M
authors.lastname: Candela
authors.forename: Raul
authors.initials: R
authors.lastname: Perez Bianco
authors.forename: Miguel
authors.initials: M
authors.lastname: Tezanos Pinto
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D005271:Femur Head Necrosis / Q000139:chemically induced*; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D008297:Male