title: Activity of thyroid parafollicular (C) cells in rats with hyperthyroidism--immunohistochemical investigations.
abstract: The aim of this study was an evaluation of the activity of parafollicular (C) cells in a rat experimental model of hyperthyroidism, evoked by an intraperitoneal application of L-thyroxine (40 mg/kg daily) over 15 days. For that reason, immunohistochemical investigations and evaluation of calcitonin (CT) plasma concentrations were performed. Differences in the quantity and distribution, together with enhanced CT-immunoreactivity of C cells, were observed in hyperthyroid rats, in comparison to respective values in the control group, accompanied by a significant diminution of plasma TSH and CT levels. Our preliminary study may point to a functional interaction between follicular and parafollicular cells in the thyroid gland.
authors.affiliation: 1st Department of General and Endocrinological Surgery, Medical University of Białystok, Poland. klchirog@amb.edu.pl
authors.forename: J
authors.initials: J
authors.lastname: Dadan
authors.forename: R L
authors.initials: RL
authors.lastname: Zbucki
authors.forename: B
authors.initials: B
authors.lastname: Sawicki
authors.forename: M M
authors.initials: MM
authors.lastname: Winnicka
authors.forename: Z
authors.initials: Z
authors.lastname: Puchalski
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006980:Hyperthyroidism / Q000139:chemically induced / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000473:pathology*; D013974:Thyroxine
chemical_list: D013974:Thyroxine