Transplantation of carotid body cells in the treatment of neurological disorders.
Laboratory and clinical studies have shown that intracerebral transplantation of carotid body (CB) cells ameliorate Parkinsonian deficits. The recent clinical study by Arjona and colleagues indicated that CB autograft transplantation is a relatively simple, safe, and viable treatment for PD patients. In particular, Espejo and colleagues demonstrated that the therapeutic efficacy of intracerebral transplantation of the CB in PD was likely obtained through secretion of neurotrophic factors rather than the local release of dopamine, which suggests it possible and reasonable to extend the use of the CB as an efficacious graft source for neural transplantation. Thus, we transplanted CB cell suspensions into the ischemic penumbra within 1h after stroke surgery. The results revealed that CB transplantation also significantly reduced stroke-induced behavioral deficits and cerebral infarction. In this review, we focus on summarizing the physiological properties of the CB related to transplantation, describing briefly possible mechanisms responsible for the effect of CB transplantation, and introducing recent studies of the CB as a donor source for neural transplantation.
Yu
Guolong
G
Department of Neurology, BI-3080, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912-3200, USA.
Fournier
Christina
C
Hess
David C
DC
Borlongan
Cesar V
CV
D000818:Animals; D002344:Carotid Body / Q000502:physiology* / Q000637:transplantation*; D017690:Cell Transplantation / Q000379:methods*; D004195:Disease Models, Animal; D006801:Humans; D009422:Nervous System Diseases / Q000628:therapy*; D020127:Recovery of Function / Q000502:physiology