Community acquired respiratory viral infections after lung transplantation: clinical features and long-term consequences.
Community acquired respiratory viruses (CARVs) are increasingly recognized as serious threats to lung transplant recipients. While CARVs such as respiratory syncytial virus, parainfluenza, influenza, and adenovirus usually cause self-limited illnesses in immunocompetent subjects, infections in the transplant recipient can be dramatic. As transplant recipients live longer and diagnostic methods improve, the burden of CARVs will undoubtedly increase. Because of limited therapeutic options, some patients may succumb to CARV infections, while many survivors develop chronic allograft dysfunction. Recognition of this latter phenomenon has implicated CARVs in the pathogenesis of bronchiolitis obliterans.
Chakinala
Murali M
MM
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. chakinalam@wustl.edu
Walter
Michael J
MJ
D001989:Bronchiolitis Obliterans / Q000821:virology; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000628:therapy / Q000821:virology; D006801:Humans; D008168:Lung / Q000473:pathology; D016040:Lung Transplantation / Q000009:adverse effects*; D020545:Respiratory Mucosa / Q000473:pathology; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000628:therapy / Q000821:virology; D013997:Time Factors; D014777:Virus Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy