title: Efficacy of mechanical prophylaxis for venous thromboembolism in patients with brain tumors.
abstract: Patients with brain tumors are at considerable risk for the formation of venous thromboemboli. One method of preventing these complications is mechanical prophylaxis in which an external pneumatic compression device and graduated elastic compression stockings are used. Evidence indicates that these devices prevent deep venous thrombosis (DVT) and pulmonary embolism (PE) by limiting venous stasis and increasing fibrinolytic activity at both the local and systemic levels. The authors present evidence for the occurrence of both mechanisms and discuss the use of mechanical compression in the setting of surgery for brain tumors. They also present data proving the efficacy of these devices in patients who undergo craniotomy with motor mapping for resection of glioma and in whom the contralateral leg receives no prophylaxis. Finally, they comment on the use of anticoagulation therapy both in addition to and in place of mechanical prophylaxis.
authors.affiliation: Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco School of Medicine, San Francisco, California 94143-0112, USA. Augustek@neurosurg.ucsf.edu
authors.forename: Kurtis I
authors.initials: KI
authors.lastname: Auguste
authors.forename: Alfredo
authors.initials: A
authors.lastname: Quiñones-Hinojosa
authors.forename: Mitchel S
authors.initials: MS
authors.lastname: Berger
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001458:Bandages; D001932:Brain Neoplasms / Q000150:complications* / Q000628:therapy; D006801:Humans; D048228:Intermittent Pneumatic Compression Devices; D013923:Thromboembolism / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D020246:Venous Thrombosis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants