Identification and complementation of a mutation associated with loss of Mycoplasma pneumoniae virulence-specific proteins B and C.
A mutation in gene MPN142 (orf6) was identified in the Mycoplasma pneumoniae cytadherence mutant III-4. MPN142 encodes virulence-specific proteins P90 and P40 (proteins B and C, respectively). Analysis of MPN142 in a cytadhering revertant and complementation using a recombinant wild-type allele confirmed the role of this mutation in the cytadherence defect.
Waldo
Robert H
RH
Department of Microbiology, 523 Biological Sciences Bldg., University of Georgia, Athens, GA 30602, USA.
Jordan
Jarrat L
JL
Krause
Duncan C
DC
D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics*; D004252:DNA Mutational Analysis; D005816:Genetic Complementation Test; D009154:Mutation; D009177:Mycoplasma pneumoniae / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology; D037521:Virulence Factors / Q000096:biosynthesis* / Q000235:genetics*
D001426:Bacterial Proteins; D037521:Virulence Factors