Prevalence of human papilloma virus type 5 DNA in lesional and non-lesional skin scales of Italian plaque-type psoriatic patients: association with disease severity.
Human papilloma virus type 5 (HPV-5) has been associated closely with psoriatic skin in Polish patients, while findings from other countries have indicated a more limited prevalence. The results of the present study, in which a type-specific nested PCR was used, indicated that scales of plaque-type psoriatic skin from 54 Italian patients had a high prevalence (74.1%) of HPV-5 DNA in lesional areas, and a reduced prevalence (33.3%) in non-lesional skin (33.3%), compared to 0% of 20 healthy subjects and 3.6% in the lesional areas of 28 patients with various other dermatological diseases. Individuals negative for HPV-5 DNA had a less severe disease. No correlation was found between the presence of HPV DNA and a patient's age or sex. The data demonstrated a statistically significant association between psoriasis and HPV-5, although results in other geographical areas suggest variable virus spread or ethnic variation in virus colonisation.
Prignano
G
G
Institute San Gallicano and Hospital 'San Giovanni Calibita', FBF/AFAR, Rome, Italy.
Ferraro
C
C
Mussi
A
A
Stivali
F
F
Trento
E
E
Bordignon
V
V
Crescimbeni
E
E
Salvati
G
G
Degener
A M
AM
Ameglio
F
F
D000328:Adult; D004279:DNA, Viral / Q000032:analysis* / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology; D015995:Prevalence; D011565:Psoriasis / Q000473:pathology / Q000821:virology*; D012720:Severity of Illness Index; D012867:Skin / Q000473:pathology* / Q000821:virology*
D004279:DNA, Viral