Stereoselective synthesis of beta-amino acids.
A convenient method for the stereoselective syntheses of beta-amino acids with alpha-substitutions has been developed. This synthetic route involves the preparation of isoxazolidinones through hydroxylamine addition to unsaturated esters and subsequent hydrogenation. This procedure is also useful for the stereoselective syntheses of alpha-deuterated beta-amino acids.
Guo
Hong-Sheng
HS
College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China.
Zhao
Hong-Juan
HJ
Niu
De-Qiang
DQ
Zhao
Kang
K
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D006865:Hydrogenation; D019811:Hydroxylamine / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
D000596:Amino Acids; D004952:Esters; D023303:Oxazolidinones; D019811:Hydroxylamine