title: Stereoselective synthesis of beta-amino acids.
abstract: A convenient method for the stereoselective syntheses of beta-amino acids with alpha-substitutions has been developed. This synthetic route involves the preparation of isoxazolidinones through hydroxylamine addition to unsaturated esters and subsequent hydrogenation. This procedure is also useful for the stereoselective syntheses of alpha-deuterated beta-amino acids.
authors.affiliation: College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China.
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Guo
authors.forename: Hong-Juan
authors.initials: HJ
authors.lastname: Zhao
authors.forename: De-Qiang
authors.initials: DQ
authors.lastname: Niu
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D006865:Hydrogenation; D019811:Hydroxylamine / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D004952:Esters; D023303:Oxazolidinones; D019811:Hydroxylamine