title: Simultaneous optical coherence tomography--Indocyanine Green dye fluorescence imaging system for investigations of the eye's fundus.
abstract: We have developed a dual-channel optical coherence tomography-Indocyanine Green dye (OCT-ICG) fluorescence system based on a previously reported ophthalmic OCT confocal imaging system. The confocal channel is tuned to the fluorescence wavelength range of the ICG, and light from the same optical source is used to generate the OCT image and to excite the ICG fluorescence. The system enables the clinician to visualize simultaneously en face OCT slices and corresponding ICG angiograms of the ocular fundus, displayed side by side. C-scan (constant depth) and B-scan (cross section) images are collected by a fast en face scan (T scan). The pixel-to-pixel correspondence between the OCT and angiography images allows the user to capture OCT B scans precisely at selected points on the ICG confocal images.
authors.affiliation: Applied Optics Group, University of Kent, Canterbury, UK. g.dobre@kent.ac.uk
authors.forename: George M
authors.initials: GM
authors.lastname: Dobre
authors.forename: Adrian Gh
authors.initials: AG
authors.lastname: Podoleanu
authors.forename: Richard B
authors.initials: RB
authors.lastname: Rosen
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005451:Fluorescein Angiography / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007208:Indocyanine Green; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique / Q000295:instrumentation*; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods
chemical_list: D007208:Indocyanine Green