Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study.
We obtained [11C](R)-PK11195 PET scans in six patients at different time points between 3 and 150 days after onset of ischemic stroke in order to measure the time course of microglial activation. Increased [11C](R)-PK11195 binding around the lesion was observed as early as 3 days. Scans at later time points showed ongoing changes in the distribution of the [11C](R)-PK11195 signal, involving the area of the primary lesion and areas distant from the primary lesion site. Our data suggest that [11C](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration.
Gerhard
Alexander
A
MRC Clinical Sciences Centre and Department of Neuropathology, Faculty of Medicine, Imperial College, London, UK. alexander.gerhard@csc.mrc.ac.uk
Schwarz
Johannes
J
Myers
Ralph
R
Wise
Richard
R
Banati
Richard B
RB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D001933:Brain Stem / Q000098:blood supply; D002250:Carbon Radioisotopes; D002536:Cerebral Arteries; D006801:Humans; D007546:Isoquinolines; D017628:Microglia / Q000502:physiology*; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods
D002250:Carbon Radioisotopes; D007546:Isoquinolines; C037850:PK 11195