title: Cancer risk estimates for gamma-rays with regard to organ-specific doses Part II: site-specific solid cancers.
abstract: Part I of this study presented an analysis of the solid cancer mortality data for 1950-1997 from the Japanese life-span study of the A-bomb survivors to assess the cancer risk for gamma-rays in terms of the organ-specific dose for all solid cancers combined. Compared to earlier analyses, considerably more curvature in the dose-effect relation is indicated by these computations, which now suggests a dose and dose-rate effectiveness factor of about 2. The computations are extended here in order to explore the site-specific solid cancer risks for various organs. A computational method has been developed whereby the site-specific cancer risks are all simultaneously computed with global age and gender effect modifiers. This provides a more parsimonious representation with fewer parameters and avoids the large relative standard errors which would otherwise result. The sensitivity of site-specific risks to the choices of the neutron RBE is examined. The site-specific risk estimates are quite sensitive to the neutron RBE for the least shielded organs such as the breast, bladder and oesophagus. For the deeper lying organs, such as the gallbladder, pancreas and uterus, the impact of the neutrons is much lower. With an assumed neutron RBE of 35, which is in line with results on low neutron doses in major past studies on rodents and which corresponds approximately to the current ICRP radiation weighting factor for neutrons, the neutrons appear to contribute about 40% of the observed excess cancer risk in the breast, i.e. the organ that is closest to the body surface. However, this neutron contribution fraction is only about 10% for deeper lying organs, such as the colon.
authors.affiliation: Radiobiological Institute, University of Munich, Schillerstrasse 42, 80336 Munich, Germany. Linda.Walsh@LRZ.uni-muenchen.de
authors.forename: Linda
authors.initials: L
authors.lastname: Walsh
authors.forename: Werner
authors.initials: W
authors.lastname: Rühm
authors.forename: Albrecht M
authors.initials: AM
authors.lastname: Kellerer
mesh_terms: D000465:Algorithms; D001822:Body Burden; D003198:Computer Simulation; D005720:Gamma Rays; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000401:mortality*; D009689:Nuclear Warfare; D009928:Organ Specificity; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods*; D012062:Relative Biological Effectiveness; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D016019:Survival Analysis; D017741:Survivors / Q000706:statistics & numerical data