[Effect of sodium iron chlorophyllin (SIC) on CFU-E and CFU-GM yields of normal and anemic animal models].
OBJECTIVE
To observe the effect of sodium iron chlorophyllin (SIC) on hematopoiesis and its therapeutic efficacy in anemic mice.


METHODS
The effects of SIC on CFU-E and CFU-GM yields of normal and anemic animal models were studied.


CONCLUSIONS
(1) SIC significantly enhanced the CFU-E and CFU-GM yields of mouse bone marrow. (2) SIC also increased the percentage of reticulocyte in mouse. (3) In hemolytic anemia mice induced by i.p. N-acetphenylhydrazine, SIC markedly prevented the decrease of RBC and Hb. (4) In hemorrhagic anemia rats induced by bleedletting, SIC accelerated the normalization of RBC, Hb and elevated the serum iron level and transferrin saturation.
Liu
X
X
Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013.
Chen
K
K
Shi
H
H
Cai
H
H
Li
L
L
Lou
J
J
Qian
B
B
D000740:Anemia / Q000097:blood / Q000276:immunology / Q000473:pathology*; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002735:Chlorophyllides / Q000494:pharmacology*; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000187:drug effects; D015672:Erythroid Precursor Cells / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D005260:Female; D055014:Granulocyte-Macrophage Progenitor Cells / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D007501:Iron / Q000097:blood; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats
D002735:Chlorophyllides; D007501:Iron; C007020:chlorophyllin