Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin.
Hepatoprotective effect of the leaves and stems of Ampelopsis grossedentata together with its main constituent, ampelopsin, were examined on D-galactosamine induced liver injury in rats. The diet containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly suppressed the increase of LDH, ALT, AST, alpha-tocopherol levels and GSG/GSSH caused by GalN treatment. These results suggested that ampelopsin from Tocha acted to prevent the oxidative stress in vivo that may have been due to active oxygen species formed by a macrophage by the action of GalN.
Murakami
Toshiyuki
T
Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089-8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729-3102, Japan.
Miyakoshi
Masazumi
M
Araho
Daisuke
D
Mizutani
Kenji
K
Kambara
Toshimitsu
T
Ikeda
Takao
T
Chou
Wen-Hua
WH
Inukai
Mihoko
M
Takenaka
Asako
A
Igarashi
Kiharu
K
D032421:Ampelopsis; D000818:Animals; D004195:Disease Models, Animal; D005688:Galactosamine / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D005688:Galactosamine