Oral vitamin K produces a normal INR within 24 hours of its administration in most patients discontinuing warfarin.
A randomized, blinded study in 30 patients was undertaken. This study found that low dose oral vitamin K was more effective than placebo when used to correct the INR in patients who are discontinuing warfarin. Larger studies will be required to determine if the use of oral vitamin K, for example in patients who are temporarily discontinuing warfarin to undergo interventional procedures, is safe and effective.
Crowther
Mark A
MA
Ageno
Walter
W
Schnurr
Terri
T
Manfredi
Elisa
E
Kinnon
Krys
K
Garcia
David
D
Douketis
James D
JD
D000284:Administration, Oral; D000368:Aged; D000925:Anticoagulants / Q000592:standards / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D019934:International Normalized Ratio / Q000379:methods; D008297:Male; D012016:Reference Values; D013997:Time Factors; D014812:Vitamin K / Q000008:administration & dosage*; D014859:Warfarin / Q000592:standards / Q000627:therapeutic use*; D028761:Withholding Treatment
D000925:Anticoagulants; D014812:Vitamin K; D014859:Warfarin