title: Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer.
abstract: The keratinocyte growth factor receptor, also known as KGFR/FGFR2 IIIb, is mainly localized in epithelial cells and participates in the proliferation of these cells. In the present study, we attempted to clarify the expression and role of KGFR in human colorectal cancer. The KGFR protein was detected in several colorectal cancer cell lines. Immuno-histochemically, KGFR was expressed on the luminal surface of epithelial cells in normal colorectal tissues. KGFR was expressed in 35 of 56 (62.5%) colorectal cancer patients and localized at the center of the cancer nests. Cytokeratin 20 (CK 20) colocalized with KGFR. In contrast, Ki-67 localized at the periphery of the cancer nests. Clinicopathologically, a high level of KGFR expression was associated with well-differentiated histological type (p<0.0001) and shallow wall invasion (p<0.0174). These findings indicate that KGFR may play important roles in the differentiation of normal colorectal epithelial cells and establishment of the well-differentiated histological type of colorectal cancer cells.
authors.affiliation: Department of Pathology II, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Yoshino
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ishiwata
authors.forename: Masanori
authors.initials: M
authors.lastname: Watanabe
authors.forename: Osamu
authors.initials: O
authors.lastname: Komine
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shibuya
authors.forename: Akira
authors.initials: A
authors.lastname: Tokunaga
authors.forename: Zenya
authors.initials: Z
authors.lastname: Naito
mesh_terms: D000368:Aged; D002454:Cell Differentiation; D003106:Colon / Q000166:cytology / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D051497:Receptor, Fibroblast Growth Factor, Type 2; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism*; D012007:Rectum / Q000166:cytology / Q000378:metabolism
chemical_list: D017468:Receptors, Fibroblast Growth Factor; D051497:Receptor, Fibroblast Growth Factor, Type 2; C065104:keratinocyte growth factor receptor