Diuretic activity of Maydis stigma extract in rats.
Maydis stigma (corn silk) is a herbal drug reputed for the treatment of urinary ailments in various traditional medicine systems. To determine its influence on urinary volume and the excretion of sodium, potassium and chloride, 5% and 10% decoctions were administered daily to adult male Wistar rats for eight days. The concentration of electrolytes and urea in plasma, the influence of treatment on urinary pH value as well as creatinine clearance were also investigated. Daily oral administration of 5% decoction at the dose of 10 ml/kg led to a significant and acute diuresis in rats, reaching the peak value in the first 24 h of treatment. Over a similar period, application of 10% decoction did not affect urinary excretion of water, but significantly increased the pH value of excreted urine. A significant decrease in sodium and chloride plasma levels was observed in both treated groups. The creatinine clearance was markedly increased after the treatment with both extracts. Our findings indicate that the diuretic effect of 5% aqueous Maydis stigma extract is in accordance with the increase in glomerular filtration rate and inhibition of sodium and chloride tubular reabsorption, caused a by still unidentified intrinsic factor, but not the salt-loading effect.
Maksimović
Z
Z
Institute of Pharmacognosy, School of Pharmacy, University of Belgrade, Belgrade, Serbia and Montenegro. zmaksim1@pharmacy.bg.ac.yu
Dobrić
S
S
Kovacević
N
N
Milovanović
Z
Z
D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry; D003404:Creatinine / Q000097:blood; D004232:Diuretics / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008297:Male; D009994:Osmolar Concentration; D010636:Phenols / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D013634:Tannins / Q000737:chemistry; D014563:Urodynamics / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects
D003374:Coumarins; D004232:Diuretics; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D013634:Tannins; D003404:Creatinine