title: Enantioseparation on mono(6A-n-allylamino-6A-deoxy)permethylated 3-cyclodextrin covalently bonded silica gel.
abstract: A chiral selector, mono(6A-N-allylamino-6A-deoxy)permethylated beta-cyclodextrin, was synthesized through a facile synthetic route and chemically immobilized onto porous silica gel via hydrosilylation to afford a cyclodextrin based chiral stationary phase MeCD-CSP. This chiral stationary phase exhibited good enantioselectivity under standard HPLC conditions. The optimal resolution of 1-(p-bromophenyl)ethanol and bromopheniramine was achieved under normal-phase conditions using a mobile phase comprising n-hexane (hexane) and 2-propanol (IPA). The enantioseparation of warfarin, suprofen and a series of flavanones under reversed-phase conditions were optimized and efficient enantioseparations for these analytes were obtained.
authors.affiliation: Department of Chemistry, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore.
authors.forename: Xiang-Hua
authors.initials: XH
authors.lastname: Lai
authors.forename: Siu-Choon
authors.initials: SC
authors.lastname: Ng
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism; D014859:Warfarin / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D044950:Flavanones; D014859:Warfarin; D058428:Silica Gel; D012822:Silicon Dioxide