title: Stimulation of the subthalamic nucleus in a patient with Parkinson disease and essential tremor.
abstract: BACKGROUND
  The preferred surgical target for the treatment of Parkinson disease (PD) is either the internal globus pallidus or the subthalamic nucleus (STN); the target for treatment of essential tremor (ET) is the thalamic subnucleus ventralis intermedius (Vim). Some patients with PD have coexistent ET, and the identification of a single surgical target to treat both parkinsonian motor symptoms and ET would be of practical importance.
  
  
  OBJECTIVE
  To describe the use of the STN target in deep brain stimulator (DBS) surgery to treat PD motor symptoms and the action-postural tremor of ET.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A 62-year-old man had a greater than 30-year history of action-postural tremor in both hands, well controlled with beta-blockers for more than 20 years. He developed resting tremor, bradykinesia, and rigidity on his right side that progressed to his left side during the past 10 years. Dopaminergic medication improved his rigidity and bradykinesia, with only mild improvement of his resting tremor and no effect on his action-postural tremor.
  
  
  METHODS
  Left pallidotomy followed by placement of a left DBS in the Vim and subsequent placement of a right STN DBS.
  
  
  METHODS
  Control of symptoms of PD and ET.
  
  
  RESULTS
  The left pallidotomy controlled the patient's parkinsonian motor symptoms on the right side of his body, but did not affect the action-postural component of his tremor. The symptoms on the left side of the body, including both an action-postural and a resting tremor (as well as the rigidity and bradykinesia), improved after placement of a single right STN DBS.
  
  
  CONCLUSIONS
  Placement of an STN DBS should be considered as the procedure of choice for surgical treatment of patients with a combination of PD and ET.
authors.affiliation: Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Natividad P
authors.initials: NP
authors.lastname: Stover
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
authors.forename: Marian L
authors.initials: ML
authors.lastname: Evatt
authors.forename: Dinesh V
authors.initials: DV
authors.lastname: Raju
authors.forename: Roy A E
authors.initials: RA
authors.lastname: Bakay
authors.forename: Jerrold L
authors.initials: JL
authors.lastname: Vitek
mesh_terms: D046690:Deep Brain Stimulation; D020329:Essential Tremor / Q000150:complications / Q000628:therapy*; D007839:Functional Laterality / Q000502:physiology / Q000528:radiation effects; D005917:Globus Pallidus / Q000528:radiation effects; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000528:radiation effects*; D016896:Treatment Outcome