Interactive DNA sequence and structure design for DNA nanoapplications.
DNA sequence and structure design is very important for DNA nanoapplications. A computer-aided design tool is needed for exploring DNA sequence and structure of interests before experimental synthesis, which is a time- and labor-consuming process. In this paper, an interactive DNA sequence and structure design software tool called DNA shop is proposed and implemented. The visualization tool can generate DNA structures by specifying, selecting, and moving DNA sequences around and display corresponding structures. Using the tool, DNA sequence and structure can be visually inspected in three-dimensional space before experimental studies.
Zhang
Mingjun
M
Life Sciences and Chemical Analysis Division, Agilent Technologies, Palo Alto, CA 94304, USA. mingjunzhang@ieee.org
Sabharwal
Chaman L
CL
Tao
Weimin
W
Tarn
Tzyh-Jong
TJ
Xi
Ning
N
Li
Guangyong
G
D000465:Algorithms; D001483:Base Sequence; D003196:Computer Graphics; D003198:Computer Simulation; D017076:Computer-Aided Design; D004247:DNA / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D015342:DNA Probes / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D021621:Imaging, Three-Dimensional / Q000379:methods; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
D015342:DNA Probes; D004247:DNA