title: Pediatric hypereosinophilic syndrome (HES) differs from adult HES.
abstract: The idiopathic hypereosinophilic syndrome (HES) developed in a 15-year-old boy who presented with colitis, cough, rash, and hepatitis. Molecular analysis failed to demonstrate the Fip1-like1-Platelet Derived Growth Factor Receptor alpha chain (FIP1L1-PDGFRA) mutation described in adult patients with HES. There are significant clinical differences between the pediatric and adult presentations of HES.
authors.affiliation: Department of Pulmonary Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Hary T
authors.initials: HT
authors.lastname: Katz
authors.forename: S Jaharul
authors.initials: SJ
authors.lastname: Haque
authors.forename: Fred H
authors.initials: FH
authors.lastname: Hsieh
mesh_terms: D000293:Adolescent; D000328:Adult; D003092:Colitis / Q000209:etiology*; D003371:Cough / Q000209:etiology*; D005076:Exanthema / Q000209:etiology*; D006505:Hepatitis / Q000209:etiology*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D016896:Treatment Outcome