title: [Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients].
abstract: OBJECTIVE
  To explore factors influencing the effectiveness of immunosuppressive therapy in severe aplastic anemia (SAA).
  
  
  METHODS
  The serum levels of interleukin-2 (IL-2) and soluble IL-2 receptor (sIL-2R) of 22 SAA patients and 15 normal controls were measured by immunoenzyme assay.
  
  
  RESULTS
  Comparing with the normal controls, 40.9% and 63.6% of the SAA patients had higher serum levels of IL-2 (>840ng/L) and of sIL 2R (>320 x 10(3) U/L), respectively. Those who had higher IL-2 levels and higher sIL-2R levels got better responses to cyclosporin A(CsA) and CsA plus antilymphocyte globulin (ALG).
  
  
  CONCLUSIONS
  The serum levels of IL-2 and sIL-2R were correlated with the responsiveness to immunosuppressive therapy in SAA patients and might be useful for directing treatment.
authors.affiliation: Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.
authors.forename: Z
authors.initials: Z
authors.lastname: Shao
authors.forename: K
authors.initials: K
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Zou
authors.forename: X
authors.initials: X
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Chu
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood* / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007165:Immunosuppression Therapy; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood* / Q000737:chemistry*; D012189:Retrospective Studies; D012995:Solubility; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007376:Interleukin-2; D015375:Receptors, Interleukin-2