title: Allergy to nickel in dental alloys.
abstract: A case of oral allergy to dental alloys is presented, highlighting the interest of dosage of salivary nickel and of flow cytometry showing a selective CD4+ activation. The discrepancy between the rarity of oral allergy to dental alloys and the frequency of nickel sensitization and nickel-induced contact dermatitis leads to discuss the mechanisms of oral tolerance.
authors.affiliation: Department of Internal Medicine, Clinical Immunology and Allergology - University Hospital, Nancy.
authors.forename: D-A
authors.initials: DA
authors.lastname: Moneret-Vautrin
authors.forename: D
authors.initials: D
authors.lastname: Burnel
authors.forename: J
authors.initials: J
authors.lastname: Sainte-Laudy
authors.forename: E
authors.initials: E
authors.lastname: Beaudouin
authors.forename: A
authors.initials: A
authors.lastname: Croizier
mesh_terms: D000328:Adult; D000485:Allergens / Q000009:adverse effects* / Q000032:analysis; D002054:Burning Mouth Syndrome / Q000209:etiology*; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D003442:Crowns; D003722:Dental Alloys / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D009532:Nickel / Q000009:adverse effects* / Q000032:analysis; D010328:Patch Tests; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012463:Saliva / Q000737:chemistry*; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology
chemical_list: D000485:Allergens; D003722:Dental Alloys; D015375:Receptors, Interleukin-2; D009532:Nickel