Copper-catalyzed anti-stereocontrolled ring-opening of azabicyclic alkenes with Grignard reagents.
[Reaction: see text] The anti-stereocontrolled alkylative ring-opening reaction of azabicyclic alkenes is reported. N-(2-Pyridyl)sulfonyl azabenzonorbornadiene reacts with Grignard reagents in the presence of catalytic amounts of CuCN to afford, in good yields and excellent anti selectivity, the corresponding dihydronaphthalene-1-amines.
Gómez Arrayás
Ramón
R
Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. ramon.gomez@uam.es
Cabrera
Silvia
S
Carretero
Juan C
JC