Human herpes simplex virus keratitis: the pathogenesis revisited.
Infections with several members of the human herpesviruses are the cause of significant ocular morbidity. Of the human herpesviruses, HSV-1 is the most frequent cause of primary and recurrent eye disease. Despite the availability of effective antiviral treatment, recurrent HSV-1 infection continues to be the leading cause of corneal blindness in industrialized nations. This review recapitulates the current insights in the role of the virus and the intra-corneal T cell response involved in the pathogenesis of human HSV-1-induced keratitis.
Remeijer
Lies
L
The Rotterdam Eye Hospital, Cornea and External Disease Service, Rotterdam, The Netherlands. schoerem@bart.nl
Osterhaus
Albert
A
Verjans
Georges
G
D018259:Herpesvirus 1, Human / Q000472:pathogenicity*; D006801:Humans; D016849:Keratitis, Herpetic / Q000209:etiology* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology