Novel cytotoxic thiodiketopiperazine derivatives from a Tilachlidium sp.
Three novel thiodiketopiperazine derivatives, T988 A, B, and C (1-3), were isolated from a Tilachlidium sp. Their structures were elucidated by spectroscopic analyses using various 1D and 2D NMR techniques. All the compounds showed potent cytotoxicity against cultured P388 leukemia cells.
Feng
Yunjiang
Y
Department of Chemistry and School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
Blunt
John W
JW
Cole
Anthony L J
AL
Munro
Murray H G
MH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000737:chemistry*; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010879:Piperazines; C497288:T988 A compound; C497289:T988 B compound; C497290:T988 C compound