Concentration of transforming growth factor beta2 in aqueous humor.
The total transforming growth factor (TGF) beta(2) concentration in the anterior chamber aqueous humor of 96 cataract patients with ages ranging from 17 to 88 years was measured using ELISA to investigate the changes that occur with age, difference of axial length, difference of localization of opacification of the cataractous lens and complications with other eye diseases. It was found that the total TGF-beta(2) concentration (1) decreases with age, (2) shows slight changes with axial length, (3) has slight changes with difference of localization of opacification, (4) is significantly high in patients with concurrent open-angle glaucoma (p < 0.05), (5) is high in patients with complicating diabetes who have undergone panretinal photocoagulation for diabetic retinopathy (p < 0.05) and (6) is low in patients with atopic cataracts. There have been several reports on point 4 above, but none to date of the other points. These findings provide useful information on the intraocular activity of TGF-beta(2).
Yamamoto
Naoki
N
Laboratory of Molecular Biology, Joint Research Laboratory, Fujita Health University, Toyoake, Aichi, Japan. naokiy@fujita-hu.ac.jp
Itonaga
Koichiro
K
Marunouchi
Tohru
T
Majima
Kiyoyuki
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D001082:Aqueous Humor / Q000378:metabolism*; D002386:Cataract / Q000150:complications / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000150:complications / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D053781:Transforming Growth Factor beta2
C509041:TGFB2 protein, human; D016212:Transforming Growth Factor beta; D053781:Transforming Growth Factor beta2