title: Molecular architecture of bacteriophage T4.
abstract: In studying bacteriophage T4--one of the basic models of molecular biology for several decades--there has come a Renaissance, and this virus is now actively used as object of structural biology. The structures of six proteins of the phage particle have recently been determined at atomic resolution by X-ray crystallography. Three-dimensional reconstruction of the infection device--one of the most complex multiprotein components--has been developed on the basis of cryo-electron microscopy images. The further study of bacteriophage T4 structure will allow a better understanding of the regulation of protein folding, assembly of biological structures, and also mechanisms of functioning of the complex biological molecular machines.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia. vvm@ibch.ru
authors.forename: V V
authors.initials: VV
authors.lastname: Mesyanzhinov
authors.forename: P G
authors.initials: PG
authors.lastname: Leiman
authors.forename: V A
authors.initials: VA
authors.lastname: Kostyuchenko
authors.forename: L P
authors.initials: LP
authors.lastname: Kurochkina
authors.forename: K A
authors.initials: KA
authors.lastname: Miroshnikov
authors.forename: N N
authors.initials: NN
authors.lastname: Sykilinda
authors.forename: M M
authors.initials: MM
authors.lastname: Shneider
mesh_terms: D000818:Animals; D017122:Bacteriophage T4 / Q000737:chemistry* / Q000502:physiology / Q000648:ultrastructure; D011487:Protein Conformation; D014764:Viral Proteins / Q000737:chemistry / Q000502:physiology; D019065:Virus Assembly
chemical_list: D014764:Viral Proteins; C057839:fibritin protein, Enterobacteria phage T4