[Pharmacodynamics of tongue tissue and plasma after intraarterial infusion of cis-diammine glycolato platinum (CDGP)].
We measured total Pt concentration in serum and tongue tissue in CDGP intraarterial infusion with male rats. Subjects were 40 male rats sorted into intraarterial infusion (n=20), intravenous infusion (n=20), and CDGP infusion groups at a dose of 10 mg/kg. Total Pt concentration was measured every 30 minutes for 120 minutes after CDGP infusion was completed. Total Pt concentration in tongue tissue was measured on the dosage and nondosage side. Total Pt concentration on the dosage side of tongue tissue of the intraarterial infusion group was higher than in the intravenous infusion group for 120 minutes. Total Pt concentration in intraarterial infusion group tongue tissue on the dosage side was higher than on the nondosage side for 120 minutes. Serum total Pt concentration, total Pt concentration in nondosage side tongue tissue, AUC of total Pt in serum, elimination half-life (t1/2) did not show a difference in the intraarterial or intravenous infusion groups. Total Pt AUC in tongue tissue on the intraarterial infusion group dosage side was greater than in others. In intraarterial infusion of CDGP, Pt concentration in tongue tissue is higher than in intravenous infusion. Serum Pt concentration, did not differ by group. This study showed that intraarterial infusion of CDGP has the potency to become a chemotherapy indication the same as intravenous infusion, in addition to the target organ.
Matsui
Takamichi
T
Department of Otolaryngology, Fukushima Medical University School of Medicine, Fukushima.
Kano
Makoto
M
D000818:Animals; D000970:Antineoplastic Agents / Q000097:blood / Q000493:pharmacokinetics*; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008297:Male; D009944:Organoplatinum Compounds / Q000097:blood / Q000493:pharmacokinetics*; D010984:Platinum / Q000097:blood / Q000493:pharmacokinetics; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution; D014059:Tongue / Q000378:metabolism*
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D010984:Platinum; C053989:nedaplatin