Activity of thyroid parafollicular (C) cells in rats with hyperthyroidism--immunohistochemical investigations.
The aim of this study was an evaluation of the activity of parafollicular (C) cells in a rat experimental model of hyperthyroidism, evoked by an intraperitoneal application of L-thyroxine (40 mg/kg daily) over 15 days. For that reason, immunohistochemical investigations and evaluation of calcitonin (CT) plasma concentrations were performed. Differences in the quantity and distribution, together with enhanced CT-immunoreactivity of C cells, were observed in hyperthyroid rats, in comparison to respective values in the control group, accompanied by a significant diminution of plasma TSH and CT levels. Our preliminary study may point to a functional interaction between follicular and parafollicular cells in the thyroid gland.
Dadan
J
J
1st Department of General and Endocrinological Surgery, Medical University of Białystok, Poland. klchirog@amb.edu.pl
Zbucki
R L
RL
Sawicki
B
B
Winnicka
M M
MM
Puchalski
Z
Z
D000818:Animals; D004195:Disease Models, Animal; D006980:Hyperthyroidism / Q000139:chemically induced / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000473:pathology*; D013974:Thyroxine
D013974:Thyroxine