Radical cyclization approach to spirocyclohexadienones.
Cyclization of an aryl radical at the ipso position of a p-O-aryl-substituted acetamide or benzamide generates oxindoles or quinolones bearing spirocyclohexadienone rings. This versatile reaction is applied to formal syntheses of the vasopressin inhibitor SR121463A and aza-galanthamine.
de Turiso
Felix González-López
FG
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Curran
Dennis P
DP
D003500:Cyclization; D003510:Cyclohexanes / Q000737:chemistry*; D053138:Cyclohexenes; D013141:Spiro Compounds / Q000737:chemistry*
D003510:Cyclohexanes; D053138:Cyclohexenes; D013141:Spiro Compounds; C507608:cyclohexadienone