title: Donor intracranial bleeding is associated with advanced transplant coronary vasculopathy: evidence from intravascular ultrasound.
abstract: OBJECTIVE
  We evaluated the impact of spontaneous intracranial bleeding (ICB) in the donor on transplant coronary vasculopathy using serial intravascular ultrasound examinations.
  
  
  METHODS
  Between January 1995 and December 2000, 72 recipients underwent cardiac transplantation from donors who had experienced spontaneous ICB (ICB group). Their findings using serial intravascular ultrasound analysis at baseline (within 1 month) and 1 year after transplantation were compared with 90 recipients who had undergone transplantation from trauma donors (trauma group).
  
  
  RESULTS
  Compared with the Trauma group, the ICB group showed increased coronary intimal thickness (0.55 +/- 0.33 vs 0.39 +/- 0.3 mm; P = .034), plaque volume (3.84 +/- 2.5 vs 2.28 +/- 1.65 mm(3); P = .015) and plaque burden (7.4 vs 2%) at 1 year after transplantation.
  
  
  CONCLUSIONS
  Donor spontaneous ICB is associated with significantly increased coronary vasculopathy.
authors.affiliation: Department of Cardiovascular Medicine, Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. yamani@ccf.org
authors.forename: M H
authors.initials: MH
authors.lastname: Yamani
authors.forename: K
authors.initials: K
authors.lastname: Erinc
authors.forename: R C
authors.initials: RC
authors.lastname: Starling
authors.forename: J B
authors.initials: JB
authors.lastname: Young
authors.forename: N B
authors.initials: NB
authors.lastname: Ratliff
authors.forename: D J
authors.initials: DJ
authors.lastname: Cook
authors.forename: T
authors.initials: T
authors.lastname: Crowe
authors.forename: R
authors.initials: R
authors.lastname: Hobbs
authors.forename: G
authors.initials: G
authors.lastname: Rincon
authors.forename: C
authors.initials: C
authors.lastname: Bott-Silverman
authors.forename: R
authors.initials: R
authors.lastname: Bennett
authors.forename: N
authors.initials: N
authors.lastname: Smedira
authors.forename: E M
authors.initials: EM
authors.lastname: Tuzcu
mesh_terms: D000328:Adult; D005260:Female; D016027:Heart Transplantation / Q000401:mortality / Q000502:physiology*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging*; D008297:Male; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional