Dopamine receptor and hypertension.
Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and reactive oxygen and by interacting with vasopressin, renin-angiotensin, and the sympathetic nervous system. Decreased renal dopamine production and/or impaired dopamine receptor function have been reported in hypertension. Disruption of any of the dopamine receptors (D(1), D(2), D(3), D(4), and D(5)) results in hypertension. In this paper, we review the mechanisms by which hypertension develops when dopamine receptor function is perturbed.
Zeng
Chunyu
C
Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing City, P. R. China. cyzeng1@hotmail.com
Eisner
Gilbert M
GM
Felder
Robin A
RA
Jose
Pedro A
PA
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D011954:Receptors, Dopamine; D012964:Sodium; D004298:Dopamine