title: Abnormal cytogenetics and significant bone marrow plasmacytosis are predictive of early progression and short survival in patients with low tumor mass asymptomatic multiple myeloma.
abstract: In order to evaluate the prognostic factors for progression and survival in patients with a low tumor mass asymptomatic multiple myeloma (MM), we studied 59 patients who had a long term follow-up. Cytogenetic abnormalities (using conventional cytogenetics) were observed in 14 out of 45 analyzable patients (31%). An abnormal karyotype and a bone marrow (BM) plasmacytosis > 15% were found to be adverse prognostic factors for progression in univariate and multivariate analysis.
authors.affiliation: Service des Maladies du Sang Hôpital Claude Huriez, CHU rue Michel Polonovski 59037 Lille, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Depil
authors.forename: Xavier
authors.initials: X
authors.lastname: Leleu
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Micol
authors.forename: Celine
authors.initials: C
authors.lastname: Berthon
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Laï
authors.forename: Francis
authors.initials: F
authors.lastname: Bauters
authors.forename: Bruno
authors.initials: B
authors.lastname: Quesnel
authors.forename: Thierry
authors.initials: T
authors.lastname: Facon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology*; D002869:Chromosome Aberrations; D018450:Disease Progression; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology*; D011379:Prognosis; D015996:Survival Rate; D013997:Time Factors