Comparison of quantitative angiographic parameters with the magnitude of neointimal hyperplasia measured by volumetric intravascular ultrasound in patients treated with bare metal and nonpolymeric paclitaxel-coated stents.
We used data from the ASian Paclitaxel-Eluting Stent Clinical Trial (a 3-center, randomized, placebo-controlled trial of nonpolymeric paclitaxel-coated stents with a single-center intravascular ultrasound substudy) to compare angiographic indexes of drug-eluting stent efficacy with the magnitude of intimal hyperplasia (IH) assessed by intravascular ultrasound. Overall, percent IH (IH volume divided by stent volume) was larger in restenotic lesions than in nonrestenotic lesions (46 +/- 19% vs 15 +/- 13%, p <0.0001); angiographic late loss and follow-up diameter stenoses correlated strongly with percent IH.
Mintz
Gary S
GS
Department of Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Hong
Myeong-Ki
MK
Raizner
Albert E
AE
Lee
Cheol Whan
CW
Kim
Jae-Joong
JJ
Escolar
Esteban
E
Fearnot
Neal E
NE
Park
Seong-Wook
SW
Park
Seung-Jung
SJ
Weissman
Neil J
NJ
D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging* / Q000517:prevention & control; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology*; D016503:Drug Delivery Systems; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging; D017239:Paclitaxel / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D015607:Stents; D017539:Tunica Intima / Q000000981:diagnostic imaging* / Q000473:pathology*; D018084:Ultrasonography, Interventional
D017239:Paclitaxel