[Expression of Epstein-Barr virus latent membrane protein (EBV-LMP) in human laryngeal carcinoma].
In order to investigate the expression of Epstein-Barr virus in human laryngeal carcinoma, immunohistochemical study for Epstein-Barr virus latent membrane protein (EBV LMP) was performed on 90 laryngeal specimens taken from laryngeal carcinoma patients. The results showed that LMP was localized on the cell membrane and in cytoplasm. LMP was detected in 41 of 90 (45.5%) laryngeal squamous cell carcinoma, among them the positive rates of poorly differentiated, middle differentiated and well differentiated squamous carcinoma were 44% (12/27), 52% (25/47) and 26.6% (4/15) respectively. This study indicated that EB virus was not only presented in poorly differentiated carcinoma, it was also presented in well differentiated carcinoma. The development of laryngeal squamous carcinoma is related to the infection of EB virus.
Liu
Z
Z
Institute of Virology, Chinese Academy of Prevntive Medicine, Beijing 100052.
Deng
Y
Y
Zeng
Y
Y
Li
J
J
Ding
H
H
Guo
Z
Z
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000821:virology*; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D014763:Viral Matrix Proteins / Q000378:metabolism*
D014763:Viral Matrix Proteins