title: Solid-phase synthesis of the 2(1H)-pyrazinone scaffold: a new approach toward diversely substituted heterocycles.
abstract: The first solid-phase synthesis of the 2(1H)-pyrazinone scaffold is described. The diversity at position C6 of the pyrazinone ring is determined by the choice of the starting aldehyde. Microwave-enhanced transition metal-catalyzed reactions allow easy introduction of a variety of substituents at the C3 position. This opens a way for the generation of libraries of diversely substituted 2(1H)-pyrazinones that will be screened for biological activities.
authors.affiliation: Laboratory for Organic Synthesis, Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
authors.forename: Nadya
authors.initials: N
authors.lastname: Kaval
authors.forename: Wim
authors.initials: W
authors.lastname: Dehaen
authors.forename: Erik
authors.initials: E
authors.lastname: Van der Eycken
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D008872:Microwaves; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011719:Pyrazines