title: The effects of mitomycin C and 5-fluorouracil/triamcinolone on fibrosis/scar tissue formation secondary to subglottic trauma (experimental study).
abstract: OBJECTIVE
  The aim of the study was to compare the effects of mitomycin-C (MMC) and 5-fluorouracil/triamcinolone acetonide (5-FU/TA) on the development of fibrosis/scar tissue formation of rabbit subglottic area, which is injured acutely.
  
  
  METHODS
  After standardized trauma to subglottic area the rabbits were divided into those that received treatment and those that did not (controls). The subjects were treated with either topical 0.4 mg/mL MMC or 5 mg 5-FU/TA injection. Those groups were further divided into subgroups depending on the time of examination: at 2 or 6 weeks. Each subgroup had 4 rabbits. The specimens were examined histopathologically and the measurements were performed using a software.
  
  
  RESULTS
  The fibrosis indices (FIs) of the treated subgroups were significantly less than the FIs of their corresponding control subgroups (P<.05). The difference in FIs of the MMC-treated and 5-FU/TA-treated groups was not statistically significant (P>.05). MMC and 5-FU/TA did not interfere with regeneration of the epithelium although in 2 cases treated with 5-FU/TA the regenerated epithelium showed squamous metaplasia.
  
  
  CONCLUSIONS
  Both MMC and 5-FU/TA decrease fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma. There is no significant difference between the effects of the 2 drugs.
authors.affiliation: Department of ENT, Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Istanbul, Turkey. hcincik@ttnet.net.tr
authors.forename: Hakan
authors.initials: H
authors.lastname: Cincik
authors.forename: Atila
authors.initials: A
authors.lastname: Gungor
authors.forename: Adem
authors.initials: A
authors.lastname: Cakmak
authors.forename: Atilla
authors.initials: A
authors.lastname: Omeroglu
authors.forename: Ethem
authors.initials: E
authors.lastname: Poyrazoglu
authors.forename: Sukru
authors.initials: S
authors.lastname: Yildirim
authors.forename: Engin
authors.initials: E
authors.lastname: Cekin
authors.forename: Hasan
authors.initials: H
authors.lastname: Candan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002921:Cicatrix / Q000150:complications / Q000517:prevention & control*; D005355:Fibrosis; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D007829:Laryngostenosis / Q000209:etiology / Q000517:prevention & control; D007830:Larynx / Q000293:injuries* / Q000473:pathology; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D012044:Regression Analysis; D012720:Severity of Illness Index; D014135:Tracheal Stenosis / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage / Q000627:therapeutic use*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D014221:Triamcinolone; D016685:Mitomycin; D005472:Fluorouracil