[The glycemic excursions in normal glucose tolerance individuals revealed by continuous glucose monitoring system].
OBJECTIVE
To probe more details about the daily glycemic excursions in normal glucose tolerance (NGT) individuals.


METHODS
The fluctuations of glucose levels in 43 NGT individuals were measured by continuous glucose monitoring system (CGMS) for (72 +/- 7) hours.


RESULTS
The number of glucose values detected by CGMS amounted to 858 +/- 77 with a mean absolute difference (MAD) of 8.9% +/- 3.0%. The CGMS values in this study were significantly correlated with the plasma glucose and capillary glucose measurements (n = 204, r = 0.93; n = 804, r = 0.95; both P < 0.001). The glycemic excursions revealed that the daily glycemic levels were lower at night and before meals, the climax of daily glycemic level tended to appear 1- 2 hours after meals, particularly after dinner. The average glycemic value was 5.3 mmol/L. The daily glycemic peak and nadir levels were (7.8 +/- 1.4) mmol/L and (3.9 +/- 0.7) mmol/L respectively; the difference between maximal and minimal glucose levels was (3.9 +/- 1.6) mmol/L. Twenty-seven of the 43 individuals (63%) showed glycemic excursion above 7.8 mmol/L, and 9 individuals (21%) showed brief glycemic excursion below 2.8 mmol/L. During 95% (74% - 100%) of the daytime the glycemic level drifted to and fro between 3.3 mmol/L and 7.0 mmol/L; and during 99% (87% - 100%) of the daytime the glycemic level drifted to and fro between 2.8 mmol/L and 7.8 mmol/L.


CONCLUSIONS
The profile of glycemic excursion in NGT individuals may have an important significance in defining the diagnostic cut-points and targets for glycemic control on diabetes mellitus.
Yu
Ming
M
Department of Endocrinology and Metabolism, The Sixth People's Hospital Affiliated to Jiaotong University, Shanghai Diabetes Institute, Shanghai 200233, China.
Zhou
Jian
J
Xiang
Kun-san
KS
Lu
Hui-juan
HJ
Ma
Xiao-jing
XJ
Lu
Wei
W
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods* / Q000592:standards; D019518:Postprandial Period / Q000502:physiology*; D012016:Reference Values
D001786:Blood Glucose