title: Anastomotic leakage post-esophagogastrectomy for esophageal carcinoma: retrospective analysis of predictive factors, management and influence on longterm survival in a high volume centre.
abstract: OBJECTIVE
  Anastomotic leak post-gastro-esophagectomy for esophageal carcinoma remains an important issue in immediate as well as late morbidity and mortality. Several predictive factors such as patient and technical variables have been suggested with inconsistent findings. Our aim was to compare these factors and the results of treatment of anastomotic dehiscence on short and longterm survival in our center to published data.
  
  
  METHODS
  A retrospective study of 276 consecutive patients post-Ivor-Lewis gastro-esophagogastrectomy for esophageal carcinoma between 1992 and 1999. Explanatory variables taken into account for predicting anastomotic leak included preoperative weight loss, neoadjuvant therapy, inkwelling of the anastomosis, gastric drainage procedure and involvement of longitudinal resection margins. Incidence variation over time was compared. 5-year survival was assessed using the Kaplan-Meier method.
  
  
  RESULTS
  The anastomotic leak rate was 5.1% with only minor variation over time. The 30-day mortality with anastomotic leak was 35.7% compared to 4.2% for patients without leak (P<0.05). None of the suggested explanatory variables analyzed reached statistical significance at a 5% level. On multiple logistic regression there was a trend towards gastric outlet drainage procedure which might decrease the relative risk by 61% (P=0.099). After excluding the 30-day mortality the 5-year survival with anastomotic leak was not different to those without.
  
  
  CONCLUSIONS
  None of the factors reported in the literature reached statistical significance in our series. High institutional and high surgeon volume seem to outweigh any other contributing factor. Aggressive management for substantial leaks is advocated by the authors as long term palliation does not seem to be affected once the leak has been successfully treated.
authors.affiliation: Department of Cardiothoracic Surgery, Derriford Hospital, Southwest Cardiothoracic Center, Plymouth PL6 8DH, UK. manfred.junemann@gmx.net
authors.forename: M
authors.initials: M
authors.lastname: Junemann-Ramirez
authors.forename: M Y
authors.initials: MY
authors.lastname: Awan
authors.forename: Z M
authors.initials: ZM
authors.lastname: Khan
authors.forename: J S
authors.initials: JS
authors.lastname: Rahamim
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000379:methods; D004938:Esophageal Neoplasms / Q000401:mortality / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods; D005260:Female; D005743:Gastrectomy / Q000379:methods; D006801:Humans; D008297:Male; D010166:Palliative Care / Q000379:methods; D011182:Postoperative Care / Q000379:methods; D011379:Prognosis; D012044:Regression Analysis; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D013529:Surgical Wound Dehiscence / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D016019:Survival Analysis