title: Radical cyclization approach to spirocyclohexadienones.
abstract: Cyclization of an aryl radical at the ipso position of a p-O-aryl-substituted acetamide or benzamide generates oxindoles or quinolones bearing spirocyclohexadienone rings. This versatile reaction is applied to formal syntheses of the vasopressin inhibitor SR121463A and aza-galanthamine.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
authors.forename: Felix González-López
authors.initials: FG
authors.lastname: de Turiso
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Curran
mesh_terms: D003500:Cyclization; D003510:Cyclohexanes / Q000737:chemistry*; D053138:Cyclohexenes; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D003510:Cyclohexanes; D053138:Cyclohexenes; D013141:Spiro Compounds; C507608:cyclohexadienone