title: The effect of sex on central histaminergic responses and corticosterone bioperiodicity in Sprague-Dawley rats.
abstract: Male and female rats demonstrate a difference in the relationship between food intake and H(1) receptor binding, which may be due to hormonal differences that exist. The relationship between the endocrine and histaminergic regulation and synchronization of food intake needs to be elucidated. Male and female rats fed 25% protein displayed bioperiodicity in mean corticosterone levels of 148.95+/-33.71 and 288.48+/-47.84 ng/ml, respectively. Accompanying bioperiodic times were of 22.43+/-1.35 h (males) and a period of 21.42+/-1.96 h (females). Central H(1) receptors in male rats had a mean bioperiodic value of 102.37+/-1.95 pmol/g protein with a period of 21.66+/-1.85 h, while that for females was 97.42+/-4.19 pmol/g protein with a period of 10.23+/-0.95 h. Central histaminergic activity affects feeding in rats with distinct gender variation that is bioperiodic in nature and functions as a major regulatory mechanism.
authors.affiliation: Department of Biology, Northern Caribbean University, Manchester, Jamaica.
authors.forename: Erica N
authors.initials: EN
authors.lastname: Robinson
authors.forename: Danita
authors.initials: D
authors.lastname: Saxon-Kelley
authors.forename: Amy
authors.initials: A
authors.lastname: Tiu
authors.forename: Akram-Ul
authors.initials: AU
authors.lastname: Haq
authors.forename: L Preston
authors.initials: LP
authors.lastname: Mercer
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004435:Eating; D005260:Female; D008297:Male; D010507:Periodicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D011969:Receptors, Histamine H1 / Q000502:physiology*; D012727:Sex Characteristics
chemical_list: D004044:Dietary Proteins; D011969:Receptors, Histamine H1; D003345:Corticosterone