title: Consumptive coagulopathy complicating juvenile angiofibroma.
abstract: OBJECTIVE
  To investigate the incidence and clinical significance of deranged clotting results among patients with juvenile (nasopharyngeal) angiofibroma.
  
  
  METHODS
  Twenty consecutive patients treated for juvenile angiofibroma between March 1998 and July 2002 in whom preoperative coagulation tests were performed were selected. Results were compared with normal laboratory values, and clinical and histological records were retrospectively analysed.
  
  
  RESULTS
  Four out of 20 patients were found to have abnormal tests, consistent with concurrent consumptive coagulopathies. One patient was found to have a raised D-dimer level. This resolved following removal of the lesion.
  
  
  CONCLUSIONS
  The association between larger arterio-venous malformations and disseminated intravascular coagulopathy is well described (Kasabach-Merritt syndrome). Our findings suggest that low-grade consumptive coagulopathies may also complicate smaller juvenile angiofibromas, implying that preoperative coagulation screening tests may have a role in ensuring optimal perioperative haemostasis.
authors.affiliation: Royal National Throat, Nose and Ear Hospital, London, UK.
authors.forename: Campbell
authors.initials: C
authors.lastname: Baguley
authors.forename: Guri
authors.initials: G
authors.lastname: Sandhu
authors.forename: James
authors.initials: J
authors.lastname: O'Donnell
authors.forename: David
authors.initials: D
authors.lastname: Howard
mesh_terms: D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D001780:Blood Coagulation Tests; D002648:Child; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D011300:Preoperative Care / Q000379:methods; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed