title: Assessment of acute spinal inflammation in patients with ankylosing spondylitis by magnetic resonance imaging: a comparison between contrast enhanced T1 and short tau inversion recovery (STIR) sequences.
abstract: OBJECTIVE
  To compare the performance of two different MRI sequences-T(1) weighted, fat saturated, spin echo after application of contrast medium, and short tau inversion recovery (STIR) sequences-to detect spinal inflammation in patients with ankylosing spondylitis (AS).
  
  
  METHODS
  Both MRI sequences were performed in 38 patients with active AS and compared using the MRI activity scoring system, ASspiMRI-a. One vertebral unit (VU) was defined as the region between two virtual lines drawn through the middle of each vertebral body.
  
  
  RESULTS
  Intraclass correlation coefficients were excellent-0.91 and 0.86 for the Gd-DTPA and STIR sequences, respectively. The overall correlation of the single MRI scores for both sequences was also good (r = 0.84, p = 0.01). The intrarater variance was 6.71 and 9.41 and the interrater variance was 13.16 and 19.04 for the Gd-DTPA and STIR sequences, respectively. The smallest detectable distance was 4.7 and 5.6 for the Gd-DTPA and STIR sequences, respectively. The concordance rate for both sequences was 83.5% (range 80.5-87.7% in the three spinal segments). Inflammatory spinal lesions were found in 10.1% of the VUs in the STIR sequence but not in the T(1)/Gd-DTPA sequence, while the T(1)/Gd-DTPA sequence showed inflammatory lesions in 6.4% of the VUs that were found normal by STIR.
  
  
  CONCLUSIONS
  Both MRI techniques can evaluate active spinal lesions in patients with AS. More spinal lesions are detected by the STIR sequence, but the reliability between readings and readers is better for the Gd-DTPA sequence. The ASspiMRI-a is a reliable instrument for evaluating acute spinal changes in AS.
authors.affiliation: Rheumazentrum Ruhrgebiet, Herne, Ruhr University Bochum, Germany.
authors.forename: X
authors.initials: X
authors.lastname: Baraliakos
authors.forename: K-G A
authors.initials: KG
authors.lastname: Hermann
authors.forename: R
authors.initials: R
authors.lastname: Landewé
authors.forename: J
authors.initials: J
authors.lastname: Listing
authors.forename: W
authors.initials: W
authors.lastname: Golder
authors.forename: J
authors.initials: J
authors.lastname: Brandt
authors.forename: M
authors.initials: M
authors.lastname: Rudwaleit
authors.forename: M
authors.initials: M
authors.lastname: Bollow
authors.forename: J
authors.initials: J
authors.lastname: Sieper
authors.forename: D
authors.initials: D
authors.lastname: van der Heijde
authors.forename: J
authors.initials: J
authors.lastname: Braun
mesh_terms: D000208:Acute Disease; D000328:Adult; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000175:diagnosis*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA