title: Interactive DNA sequence and structure design for DNA nanoapplications.
abstract: DNA sequence and structure design is very important for DNA nanoapplications. A computer-aided design tool is needed for exploring DNA sequence and structure of interests before experimental synthesis, which is a time- and labor-consuming process. In this paper, an interactive DNA sequence and structure design software tool called DNA shop is proposed and implemented. The visualization tool can generate DNA structures by specifying, selecting, and moving DNA sequences around and display corresponding structures. Using the tool, DNA sequence and structure can be visually inspected in three-dimensional space before experimental studies.
authors.affiliation: Life Sciences and Chemical Analysis Division, Agilent Technologies, Palo Alto, CA 94304, USA. mingjunzhang@ieee.org
authors.forename: Mingjun
authors.initials: M
authors.lastname: Zhang
authors.forename: Chaman L
authors.initials: CL
authors.lastname: Sabharwal
authors.forename: Weimin
authors.initials: W
authors.lastname: Tao
authors.forename: Tzyh-Jong
authors.initials: TJ
authors.lastname: Tarn
authors.forename: Ning
authors.initials: N
authors.lastname: Xi
authors.forename: Guangyong
authors.initials: G
authors.lastname: Li
mesh_terms: D000465:Algorithms; D001483:Base Sequence; D003196:Computer Graphics; D003198:Computer Simulation; D017076:Computer-Aided Design; D004247:DNA / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D015342:DNA Probes / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D021621:Imaging, Three-Dimensional / Q000379:methods; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
chemical_list: D015342:DNA Probes; D004247:DNA