[Dynamics of the cytokines, homocysteine contents, indices of oxydative and nitrosative stress and cytopathic hypoxia in patients after cholecystectomy for acute cholecystitis. Connection with rate of postoperative purulent-inflammatory complications].
At examination of 160 patients with acute cholecystitis (ACH) it was stated that on 1st-2nd day after cholecystectomy the patients with complicated course of ACH have had a real increase of levels of interleukin-6, tumor necrosis factor-alpha, homocysteine, metabolites of nitric oxide, indexes of cytopathic hypoxia (hypoxanthine and xanthine, activity of adenosine deaminase, xanthine oxidase and xanthine dehydrogenase). These alterations were the most significant and lingering at the patients who has postoperative complications. Addition of levels of proinflammatory cytokines was over 50% and of indexes of cytopathic hypoxia--over 30-40% on the 1st-2nd day after operation what makes it possible to prognose the postoperative pyoinflammatory complications appearance at more that 60% of patients and to forecast favourable course of postoperative period with reliability over 90%--for its absence.
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D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002763:Cholecystectomy / Q000379:methods*; D002764:Cholecystitis / Q000453:epidemiology / Q000378:metabolism / Q000601:surgery; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006710:Homocysteine / Q000378:metabolism*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015538:Nitrosation; D018384:Oxidative Stress / Q000502:physiology*; D011183:Postoperative Complications / Q000453:epidemiology; D013530:Surgical Wound Infection / Q000453:epidemiology*
D016207:Cytokines; D006710:Homocysteine