title: [Cyclic GMP as a biomarker for cardiovascular disease and cancer].
abstract: BACKGROUND
  Levels of cyclic guanosine 3',5'-monophosphate (cGMP) are elevated in plasma and urine from patients with some cardiovascular diseases and some types of cancer.
  
  
  METHODS
  This paper is based on studies of cGMP as a biomarker.
  
  
  CONCLUSIONS
  It is well documented that cGMP levels are elevated in plasma in patients with heart failure and various leukaemias and in urine from patients with gynaecological cancers. Because of great interindividual variation in levels, cGMP is less suitable in primary diagnostics, but appears to be a sensitive marker in individual follow up in some diseases.
authors.affiliation: Klinisk farmakologisk avdeling, Universitetssykehuset Nord-Norge, 9038 Tromsø.
authors.forename: Line
authors.initials: L
authors.lastname: Ulvestad
authors.forename: Georg
authors.initials: G
authors.lastname: Sager
mesh_terms: D015415:Biomarkers / Q000032:analysis* / Q000097:blood / Q000652:urine; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood / Q000652:urine; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000201:enzymology*; D006152:Cyclic GMP / Q000032:analysis* / Q000097:blood / Q000652:urine; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000201:enzymology; D006801:Humans; D007938:Leukemia / Q000175:diagnosis / Q000201:enzymology; D008297:Male; D009369:Neoplasms / Q000175:diagnosis / Q000201:enzymology*
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D006152:Cyclic GMP