Synthesis and anti-implantation activity of novel non-steroidal 4,5-disubstituted 2,3,4,5-tetrahydro-1-benzoxepines.
The synthesis and anti-implantation activity of some novel 4,5-disubstiuted 2,3,4,5-tetrahydro-1-benzoxepins are presented. The synthesized compounds were evaluated for their anti-implantation activity in mature female Sprague-Dawley rats. The antifertility activity, as assessed by post coital anti-implantation test, was of weak potency for most of the compounds. Compounds 9d and 10d exhibited the highest anti-implantation activity among the tested compounds.
Rai
Sanjay
S
Institut für Organische Chemie, Universität Regensburga, Regensburg, Germany.
Tandon
Vishnu K
VK
D000818:Animals; D001584:Benzoxepins / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
D001584:Benzoxepins; D007202:Indicators and Reagents