Transcriptional regulation of the mouse microtubule-associated protein tau.
The microtubule-associated protein (MAP) tau is found primarily in neurons and errors in its regulation are associated with Alzheimer's disease and other neurodegenerative disorders. Tau expression is transcriptionally regulated and tissue-specific. In this study, starting with a approximately 7500-bp fragment from the mouse tau gene, which includes tau exon -1, we define regions preferentially conferring tissue-specific expression. Furthermore, gel shift assays indicate that transcriptional regulators SP-1 and AP-2 are important for basal expression but not necessary for neuron-specific expression of the tau transcript.
Gao
Lei
L
Shriver Center for Mental Retardation, Waltham, MA 02452, USA.
Tucker
Kerry L
KL
Andreadis
Athena
A
D000818:Animals; D001483:Base Sequence; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D051379:Mice; D008870:Microtubules / Q000378:metabolism; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D051381:Rats; D016415:Sequence Alignment; D014158:Transcription, Genetic / Q000502:physiology*; D016875:tau Proteins / Q000235:genetics / Q000502:physiology*
D016875:tau Proteins