title: Cytotoxic triterpenoid saponins from Symplocos chinensis.
abstract: Six new triterpenoid saponins were isolated as methyl or butyl esters from an n-BuOH extract of the roots of Symplocos chinensis. Their structures were established as symplocososides A (1), B (2), C (3), D (4), E (5), and F (6), by extensive 1D and 2D NMR as well as HR-MS analysis and chemical methods. Compounds 1, 3, and 6 were cytotoxic against one or more cell lines, and the derivative from 1 (1d) showed significant selectivities between KB cells and normal cells.
authors.affiliation: Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.
authors.forename: Meijun
authors.initials: M
authors.lastname: Tang
authors.forename: Diandian
authors.initials: D
authors.lastname: Shen
authors.forename: Youcai
authors.initials: Y
authors.lastname: Hu
authors.forename: Song
authors.initials: S
authors.lastname: Gao
authors.forename: Shishan
authors.initials: S
authors.lastname: Yu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes