Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
Fractionation of the marine sponge Rhabdastrella aff. distincta led to the isolation and characterization of four new isomalabaricane analogues, isogeoditin A (1), 13-(E)-isogeoditin A (2), isogeoditin B (3), and 22,23-dihydrostellettin B (4), along with seven known isomalabaricane derivatives (5-11). Methylation of 10 and 11 afforded methyl esters 12 and 13. The structures of compounds 1-4 were determined on the basis of spectroscopic data analysis. All compounds were tested against a small panel of human tumor cell lines.
Lv
Fang
F
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
Deng
Zhiwei
Z
Li
Jun
J
Fu
Hongzheng
H
van Soest
Rob W M
RW
Proksch
Peter
P
Lin
Wenhan
W
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D012118:Resorcinols; D014315:Triterpenes; C445692:geoditin A