A fermented grain food mixture, AOB, inhibits liver metastasis in the metastasis model of rat colon cancer.
Natural antioxidants have been shown to be rich sources of microchemicals with the potential to prevent human cancers. We examined whether dietary supplement of a fermented grain food mixture (AOB), which has been shown to have a strong antioxidative effect, may protect against colon cancer metastasis. At day 5 of AOB (6.5%) supplementation in a basal diet, the rat colon cancer cells (RCN-H4) were injected beneath the capsule of the spleen and one min later rats were splenectomized. All rats without AOB supplementation had multiple liver metastases. However, the number and the size of liver tumors were reduced by about 80% in AOB group. Combined use of cisplatin and AOB enhanced an anti-metastatic effect. The inhibition of liver metastasis by AOB was caused by the regulation of cell cycle. This product may be used as an adjuvant in the therapy of malignant neoplasia.
Minamiyama
Yukiko
Y
Department of Food & Health Science, Faculty of Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan. yukiko-m@md.okayama-u.ac.jp
Takemura
Shigekazu
S
Hirohashi
Kazuhiro
K
Okada
Shigeru
S
D000818:Animals; D002945:Cisplatin / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D002523:Edible Grain; D005285:Fermentation; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D051381:Rats; D011916:Rats, Inbred F344
D002945:Cisplatin