[GnRH antagonists in natural cycles].
Since the introduction of IVF treatments, natural cycle has been largely replaced by ovarian stimulation. However, natural cycle IVF has several advantages. It is associated with a close to zero multiple pregnancy rate, and a zero risk of ovarian hyperstimulation syndrome. Per cycle, natural cycle IVF is less time consuming, physically and emotionally less demanding for patients, and cheaper than stimulated IVF, but also less effective. Many cycles are cancelled because of a premature LH surge. GnRH antagonists prevent LH surge and therefore improve the results of natural IVF cycles. The GnRH antagonist should be started at day 8, at the daily dose of 0.5 mg. The natural cycle is a successful option of treatment in poor responders and implantation failure.
Frydman
R
R
Hôpital Antoine-Béclère, Clamart, France.
D000858:Anovulation / Q000097:blood / Q000188:drug therapy; D006063:Chorionic Gonadotropin / Q000494:pharmacology / Q000627:therapeutic use; D004334:Drug Administration Schedule; D010064:Embryo Implantation / Q000187:drug effects / Q000502:physiology; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000187:drug effects; D008597:Menstrual Cycle / Q000187:drug effects* / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D016896:Treatment Outcome
D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone