Magnetic resonance relaxometry in monozygotic twins discordant and concordant for schizophrenia.
T1 and T2 relaxation times were examined in four pairs of monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high genetic loading for the illness and five healthy control MZ twin pairs. Patients with schizophrenia (n = 11) showed significant prolongation in T1 relaxation times in the globus pallidus (GP) bilaterally (P < 0.005, Bonferroni corrected) when compared to 14 healthy MZ twins.
Spaniel
Filip
F
Psychiatric Center Prague, Ustavni 91, 181 03 Prague 8, Bohnice, Czech Republic. spaniel@pcp.lf3.cuni.cz
Herynek
Vit
V
Hajek
Tomas
T
Dezortova
Monika
M
Horacek
Jiri
J
Hajek
Milan
M
Kozeny
Jiri
J
Dockery
Colleen
C
Höschl
Cyril
C
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D004200:Diseases in Twins / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D013997:Time Factors; D014430:Twins, Monozygotic
D014150:Antipsychotic Agents