[Study on the relationship between the expression of adhesion molecules and the invasiveness of acute myeloid leukemia cells].
OBJECTIVE
To study the relationship between the expression of adhesion molecules CD49d (VLA-4) and CD11a (LFA-1) and the invasiveness of acute myeloid leukemia (AML) cells.


METHODS
Peripheral blood and/or bone marrow samples from 50 AML patients were investigated by APAAP and Western blotting method.


RESULTS
Extramedullary invasion developed in 32 of 50 patients (64%). The expression of CD49d and CD11a in the invasive group was much higher than that in the non-invasive group (P<0.005), while the difference between the leukemic cells from bone marrow and peripheral blood for CD49d/CD11a expression was not significant.


CONCLUSIONS
AML cells might adhere to and get through vascular endothelium by CD49d/VCAM-1 and CD11a/ICAM-1 adhesion mechanism, and the expressions of CD49d and CD11a were not critically responsible for the release of leukemic cells from bone marrow.
Liu
T
T
Institute of Haematology, Union Hospital, Tongji Medical University, Wuhan 430022.
Liu
X
X
Xiang
J
J
Zou
P
P
Zhou
J
J
Chen
Y
Y
Yu
D
D
Li
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D015153:Blotting, Western; D001854:Bone Marrow Cells / Q000378:metabolism; D040881:CD11a Antigen / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018922:HL-60 Cells; D006801:Humans; D039041:Integrin alpha4beta1 / Q000378:metabolism*; D020014:K562 Cells; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000276:immunology / Q000473:pathology*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D055815:Young Adult
D040881:CD11a Antigen; D039041:Integrin alpha4beta1