Antiretroviral therapy with tenofovir is associated with mild renal dysfunction.
A cross-sectional study was conducted to compare patients treated with tenofovir with patients never treated with tenofovir. Patients on tenofovir showed a lower mean glomerular filtration rate estimated by creatinine clearance or cystatin C clearance compared with control patients. In total, 24 patients on tenofovir versus five control patients had proteinuria greater than 130 mg/day. In the majority of patients on tenofovir proteinuria was of tubular origin.
Mauss
Stefan
S
Center for HIV and Hepatogastroenterology, Duesseldorf, Germany.
Berger
Florian
F
Schmutz
Guenther
G
D000225:Adenine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D019380:Anti-HIV Agents / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D055316:Cystatin C; D015891:Cystatins / Q000097:blood; D005919:Glomerular Filtration Rate / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D063065:Organophosphonates / Q000009:adverse effects*; D011507:Proteinuria / Q000139:chemically induced; D000068698:Tenofovir
D019380:Anti-HIV Agents; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D063065:Organophosphonates; D000068698:Tenofovir; D003404:Creatinine; D000225:Adenine