[Research advances in DNA adducts: their formation, diagnosis and pollution-exposure indication].
With the cognitive penetration of ecotoxicological effects into a molecular level, more attention has been paid to the research on DNA adducts. This paper analyzed toxic mechanisms and formative processes of DNA adducts, and introduced in brief their diagnostic methods, including chromatogram-mass spectrum method, 32P post-labeling method, immunology method and fluorescence method. The pollution-exposure indication of DNA adducts was expounded as an effective molecular biomarker, and thus, DNA adducts could be used by ecotoxicologists as a good caution signal in forecasting hazardous effects of pollutants.
Wang
Mei'e
M
Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China. wmeie03@hotmail.com
Zhou
Qixing
Q
D015415:Biomarkers / Q000032:analysis; D018736:DNA Adducts / Q000032:analysis*; D018744:DNA, Plant; D004784:Environmental Monitoring / Q000379:methods*; D004787:Environmental Pollution / Q000517:prevention & control
D015415:Biomarkers; D018736:DNA Adducts; D018744:DNA, Plant