title: Autonomic dysfunction in rheumatic diseases.
abstract: Patients who have rheumatic diseases often present with dysfunctions that are related to the autonomic nervous system (ANS) and are due to peripheral autonomic neuropathy or central changes. This article describes the prevalence of autonomic dysfunctions in patients who have rheumatic diseases. In the second part of this article, another form of ANS dysfunction-complex regional pain syndromes-is demonstrated. Clinically, these syndromes are characterized by pain (spontaneous, hyperalgesia, allodynia); active movement disorders, including an increased physiologic tremor, abnormal regulation of blood flow and sweating, edema of skin and subcutaneous tissues; and trophic changes of skin, appendages of skin, and subcutaneous tissues. In conclusion, this discussion shows that alterations of the ANS occur in rheumatic and related diseases, that these alterations may be involved in the pathogenesis of these diseases, and that we need more refined methods to study the changes that are related to the ANS.
authors.affiliation: Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany. rainer.straub@klinik.uni-regensburg.de
authors.forename: Rainer H
authors.initials: RH
authors.lastname: Straub
authors.forename: Christoph G
authors.initials: CG
authors.lastname: Baerwald
authors.forename: Matthias
authors.initials: M
authors.lastname: Wahle
authors.forename: Wilfrid
authors.initials: W
authors.lastname: Jänig
mesh_terms: D020211:Autonomic Dysreflexia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D020918:Complex Regional Pain Syndromes / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D012216:Rheumatic Diseases / Q000150:complications*