New 3-oxo-chol-4-en-24-oic acids from the marine soft coral Eleutherobia sp.
Two novel cholic acid derivatives and three known steroids were isolated from an octocoral Eleutherobiasp. from Pohnpei Micronesia along with the known briareins minabein-1 (6), minabein-4 (7), minabein-6 (8), minabein-8 (9), and minabein-9 (10). X-ray crystallographic analysis of the known compound minabein-4 allowed assignment of its correct relative and absolute stereochemistry. Consequently, a different structure proposed for the same compound (named independently as nui-inoalide-D) is incorrect.
Lievens
Sarah C
SC
Department of Chemistry, One Shields Avenue, University of California, Davis, California 95616, USA.
Hope
Håkon
H
Molinski
Tadeusz F
TF
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002793:Cholic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry*; D008849:Micronesia; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C497299:11-acetyl-3-oxo-chol-4-en-24-oic acid; C497300:3-oxo-chol-1,4,22-trien-24-oic acid; D002793:Cholic Acids; D004224:Diterpenes; D013256:Steroids