Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver.
Induction of xenobiotics metabolizing enzymes is related to the formation and chemoprevention of cancer. Since cytochrome P450s (CYPs) including CYP1A subfamily metabolize certain pro-carcinogens to their ultimate forms, down-regulation of CYP1As by food factors leads to the prevention of cancer. Mushroom polysaccharides, especially beta-glucans such as lentinan from Lentinus edodes, possess the anti-tumor and immunomodulating activities through the cytokine production from immunocytes. Recent our studies have demonstrated that lentinan suppresses hepatic CYP1As expression in the both constitutive and inducible levels through the production of tumor necrosis factor-alpha and an increase in the DNA-binding activity of nuclear factor-kappaB. This paper discusses on the effective lentinan dosage and route of administration for suppression of CYP1As.
Okamoto
Takashi
T
Department of Biofunctional Chemistry, Faculty of Agriculture, Kobe University, Rokkodai-cho 1, Nada-ku, Kobe 657-8501, Japan.
Kodoi
Rie
R
Nonaka
Yuji
Y
Fukuda
Itsuko
I
Hashimoto
Takashi
T
Kanazawa
Kazuki
K
Mizuno
Masashi
M
Ashida
Hitoshi
H
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000187:drug effects / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D007912:Lentinan / Q000302:isolation & purification / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D020942:Shiitake Mushrooms / Q000737:chemistry*
D007912:Lentinan; D001189:Aryl Hydrocarbon Hydroxylases