title: Antibacterial activity from Penicillium corylophilum Dierckx.
abstract: A strain of Penicillium corylophilum isolated from Brazilian soil sample was submitted to different culture conditions to investigate the production of secondary metabolites with antimicrobial activity. The largest number of conidia was obtained after 5 days of incubation in oat medium and the highest level of antimicrobial activity was produced when the fungus culture was developed in the Czapek medium. The activity against Staphylococcus aureus was found only in the chloroform extract from Czapek culture broth, which also showed activity against Micrococcus luteus. Fumiquinozoline F was isolated from the active chloroform extract by using chromatographic methods. The minimal inhibitory concentration (MIC) values for M. luteus and S. aureus were 99 microg/ mL and 137microg/mL, respectively.
authors.affiliation: Faculdade de Filosofia, Ciências e Letras de Formiga, Fundação Educacional Comunitária Formiguense, Avenida Dr Arnaldo de Senna, 328 CEP 35570 000 Formiga MG, Brazil.
authors.forename: Marley Garcia
authors.initials: MG
authors.lastname: Silva
authors.forename: Niege Araçari Jacometti Cardoso
authors.initials: NA
authors.lastname: Furtado
authors.forename: Mônica Tallarico
authors.initials: MT
authors.lastname: Pupo
authors.forename: Maria José Vieira
authors.initials: MJ
authors.lastname: Fonseca
authors.forename: Suraia
authors.initials: S
authors.lastname: Said
authors.forename: Ademar Alves
authors.initials: AA
authors.lastname: da Silva Filho
authors.forename: Jairo Kenupp
authors.initials: JK
authors.lastname: Bastos
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001938:Brazil; D003470:Culture Media / Q000737:chemistry; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D015394:Molecular Structure; D010407:Penicillium / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media