Genetic mapping and ENU mutagenesis.
ENU mutagenesis is a potent means to generate novel mutations in the mouse, and the further investigation of these mutations can be logistically demanding. Determination of the map position of a mutation early in its characterization can be extremely useful. We describe how the use of interval haplotype analysis can facilitate this with even small numbers of affected progeny.
Beier
David R
DR
Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. beier@receptor.med.harvard.edu
Herron
Bruce J
BJ
D000818:Animals; D002874:Chromosome Mapping; D005038:Ethylnitrosourea; D005260:Female; D005819:Genetic Markers; D006239:Haplotypes; D008297:Male; D051379:Mice; D009154:Mutation; D010375:Pedigree
D005819:Genetic Markers; D005038:Ethylnitrosourea