title: Expression and significance of heat shock protein 70 and glucose-regulated protein 94 in human esophageal carcinoma.
abstract: OBJECTIVE
  To investigate the expression and significance of heat shock protein 70 (HSP70) and glucose-regulated protein 94 (grp94) in human esophageal carcinoma and adjacent normal tissues.
  
  
  METHODS
  The expression of HSP70 and grp94 in 78 human esophageal cancer and adjacent normal tissues was studied by immunohistochemistry and pathology photograph analysis.
  
  
  RESULTS
  Both esophageal cancer and adjacent normal tissues could express HSP70 and grp94. Of the 78 cases of esophageal carcinoma, 95.0%(72/78) showed positive HSP70, mainly stained in nuclei, while grp94 was mainly stained in cell plasma, and the positive rate was 71.8%(56/78). There was a significant difference in the expression of HSP70 and grp94 between esophageal cancer and adjacent normal tissues (P<0.01). Compared with adjacent normal tissues, there was a significant difference between differential types and HSP70 expression (P<0.01).
  
  
  CONCLUSIONS
  HSP70 and grp94 express differently in cell plasma and nuclei. The expression intensity of HSP70 is related to the differentiation of esophageal carcinoma.
authors.affiliation: Department of Pathology, Capital University of Medical Sciences, Beijing 100054, China. wxpphd@yahoo.com.cn
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Wang
authors.forename: Guo-Zhen
authors.initials: GZ
authors.lastname: Liu
authors.forename: Ai-Li
authors.initials: AL
authors.lastname: Song
authors.forename: Rui-Fen
authors.initials: RF
authors.lastname: Chen
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D004947:Esophagus / Q000378:metabolism; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D018840:HSP70 Heat-Shock Proteins; D008565:Membrane Proteins; C018551:glucose-regulated proteins