Cytotoxic coumarins from the root of Angelica dahurica.
Ten coumarins were isolated from the root of Angelica dahurica by repeated silica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, oxypeucedanin hydrate acetonide (7) was isolated for the first time from this plant. Cytotoxicity of coumarins isolated were determined in vitro against L1210, HL-60, K562, and B16F10 tumor cell lines by MTT method. Pangelin (5) and oxypeucedanin hydrate acetonide (7) showed a potent cytotoxic activity with the IC50 values of 8.6 to 14.6 microg/mL against four kinds of tumor cell lines. Other compounds showed the moderate cytotoxic activity or no activity against the tumor cell lines.
Thanh
Pham Ngoc
PN
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
Jin
WenYi
W
Song
GyuYong
G
Bae
KiHwan
K
Kang
Sam Sik
SS
D029969:Angelica / Q000633:toxicity*; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018517:Plant Roots / Q000633:toxicity
D003374:Coumarins; D010936:Plant Extracts