title: Significant correlation of matrix metalloproteinase and macrophage colony-stimulating factor serum concentrations in patients with head and neck cancer.
abstract: Serum matrix metalloproteinases (MMPs) and the macrophage colony-stimulating factor (M-CSF) are of potential interest as serum tumor markers in various malignancies. There is still a lack of reliable tumor markers in patients with squamous cell carcinoma of the head and neck (SCCHN). Therefore, the tumor marker potential of MMPs and M-CSF was investigated in these malignancies. Serum of 59 patients suffering from SCCHN and of 59 healthy volunteers was obtained. The concentration of MMP-3, MMP-8, MMP-9, and M-CSF was determined by sandwich enzyme immunoassays. The MMP- 3, -8, -9, as well as the M-CSF serum concentrations were significantly elevated in the patient group, compared to the healthy controls (p<0.001, p<0.05, p<0.001, p=0.002). There was significant correlation between the M-CSF and the MMP-3 serum concentration (p<0.0001), and between the M-CSF and the MMP-8 serum concentration (p=0.005). A significant correlation with the tumor stage was found only for MMP-8. MMP and M-CSF serum concentrations are of potential interest as serum tumor markers in SCCHN.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Marburg, 35037 Marburg, Germany. kuropkat@med.uni-marburg.de
authors.forename: C
authors.initials: C
authors.lastname: Kuropkat
authors.forename: A A
authors.initials: AA
authors.lastname: Duenne
authors.forename: U
authors.initials: U
authors.lastname: Herz
authors.forename: H
authors.initials: H
authors.lastname: Renz
authors.forename: J A
authors.initials: JA
authors.lastname: Werner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000201:enzymology; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000201:enzymology; D006801:Humans; D007124:Immunoenzyme Techniques; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000097:blood; D020784:Matrix Metalloproteinase 8 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D020782:Matrix Metalloproteinases / Q000097:blood*; D008875:Middle Aged; D012016:Reference Values; D012044:Regression Analysis
chemical_list: D014408:Biomarkers, Tumor; D016173:Macrophage Colony-Stimulating Factor; D020782:Matrix Metalloproteinases; D019278:Matrix Metalloproteinase 3; D020784:Matrix Metalloproteinase 8; D020780:Matrix Metalloproteinase 9