[The study of HLA-Cw polymorphism in Uygur population].
The HLA-Cw loci polymorphism in Uygur population was investigated using the PCR- sequence specific oligonucleotide probe (SSOP) method,and the genetic database on the distribution of gene frequency of the HLA-Cw loci was established. From 146 individuals of Uygur population,18 HLA-Cw alleles were detected. The gene frequency was from 0.0069 to 0.2460. The four most common alleles were HLA-Cw*04(24.60%),07(11.51%),08(10 10%),14(12.02%),and they covered 58.23% of total alleles detected from Uygur population.We have made a survey of HLA-Cw alleles frequencies in a Uygur population,with blank frequency being lowered to 0.0064. The distribution of genotype frequencies met the law of Hardy-Weinberg equilibrium by hi-square test. The frequency data can be used in forensic and paternity tests to estimate the frequency of a DNA profile in the Uygur population,transplant matching and anthropology.
Zhang
Hong-Bo
HB
National Laboratory of Forensic Sciences, Xi'an Jiaotong University, Xi'an 710061, China. zhanghb@mail.xjtu.edu.cn
Zhao
Jun-Hai
JH
Lai
Jiang-Hua
JH
Chen
Teng
T
Li
Sheng-Bin
SB
Lai
Shu-Ping
SP