title: [Protective effect of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury in rats].
abstract: OBJECTIVE
  To evaluate protective effects of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury (TBI) in rats.
  
  
  METHODS
  The polysaccharides (RTP) were extracted from Tanguficum Maxim. 120 rats were divided into 15 groups, with 8 rats in each group. RTP at 100, 200 and 400 mg x kg(-1) were administrated orally once a day for five days, and model of brain injury was made by dropping weight method.
  
  
  RESULTS
  RTP reduced water content and malondialdehyde (MDA) levels, and increased total SOD activity and Na+-K+ ATPase activity after injuried.
  
  
  CONCLUSIONS
  The polysaccharides may be one of the effective comptents in Rheum tanguticum, showing significant neuroprotective effects.
authors.affiliation: Department of Pharmacology, the Fourth Military Medical University, Xian Shaanxi 710032, China.
authors.forename: Zhi-peng
authors.initials: ZP
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Qi-bing
authors.initials: QB
authors.lastname: Mei
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Gu
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.forename: Da-kuan
authors.initials: DK
authors.lastname: Gao
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D002540:Cerebral Cortex / Q000201:enzymology* / Q000648:ultrastructure; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012250:Rheum / Q000737:chemistry; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D018696:Neuroprotective Agents; D011134:Polysaccharides; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000254:Sodium-Potassium-Exchanging ATPase