TiCl4-promoted multicomponent reaction: a new entry to functionalized alpha-amino acids.
TiCl(4)-promoted multicomponent reactions involving N-tosyl imino ester, cyclic enol ether, and silane reagents in a single one-pot operation provide functionalized alpha-amino acids with multiple stereogenic centers in good to excellent yields. Cis/trans selectivities with optically active substituted dihydrofurans have been investigated.
Ghosh
Arun K
AK
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA. arunghos@uic.edu
Xu
Chun-Xiao
CX
Kulkarni
Sarang S
SS
Wink
Donald
D
D000596:Amino Acids / Q000737:chemistry*; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D014025:Titanium / Q000737:chemistry*
D000596:Amino Acids; C025096:titanium tetrachloride; D014025:Titanium