[Molecular biology of the retinol-binding proteins and their genes].
Retinol-binding proteins (RBPs) are a kind of circulating carrier proteins for serum and cellular retinol and retinol acid, which are lipid-soluble vitamins, and are members of hydrophobic binding protein family. Serum RBPs were synthesized primarily in liver, then was released into blood streams, and then to various tissues. Under the interaction with substances such as retinol, pre-albumin and the receptors of cellular surface, they play important roles in storage, metabolism of VitA and transport of VitA to the target cells. Cellular RBPs play the similar function as serum RBPs in intracell. This review introduces action mechanism, tissue localization and developmental expression of retinol-binding proteins. This review also introduces the structure, chromosome mapping and their relationships with reproductive performance of retinol-binding protein genes.
Guo
Xiao-Hong
XH
College of Animal Science and Technology, Shanxi Agricultural University, Taigu 030 801, China. guoxiaohong313@163.com
Chu
Ming-Xing
MX
Zhou
Zhong-Xiao
ZX
D000818:Animals; D001947:Breeding; D002874:Chromosome Mapping; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D012177:Retinol-Binding Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D054840:Retinol-Binding Proteins, Cellular; D014599:Uterus / Q000378:metabolism; D014801:Vitamin A / Q000378:metabolism*
C518456:RBP1 protein, human; C518459:RBP2 protein, human; D012333:RNA, Messenger; D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular; D014801:Vitamin A