title: [Advance in researches on BRCA1].
abstract: BRCA1 is one of the most important breast cancer susceptibility genes. It plays key roles in DNA damage repair, cell cycle checkpoint regulation, gene transcription chromatin stability, and cell proliferation. In this paper, advance in basic researches on BRCA1 is reviewed, and the role of BRCA1 in cancer development and progression is discussed, that may facilitate potential clinical application of BRCA1.
authors.affiliation: Beijing Institute of Biotechnology, Beijing 100 850, China. jinghuayan@hotmail.com
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Yan
authors.forename: Qi-Nong
authors.initials: QN
authors.lastname: Ye
authors.forename: Cui-Fen
authors.initials: CF
authors.lastname: Huang
mesh_terms: D000818:Animals; D019313:BRCA1 Protein / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002453:Cell Cycle; D049109:Cell Proliferation; D042002:Chromatin Assembly and Disassembly; D004260:DNA Repair; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D014158:Transcription, Genetic
chemical_list: D019313:BRCA1 Protein