UK-2A, B, C and D, novel antifungal antibiotics from streptomyces sp. 517-02 VI (3). Role of substituents on dilactone ring of UK-2A and antimycin A3 against generation of reactive oxygen species in porcine renal proximal tubule LLC-PK1 cells.
Fujita
Ken-Ichi
K
Graduate School of Science, Osaka City University 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan. kfujita@sci.osaka-cu.ac.jp
Kiso
Tetsuo
T
Usuki
Yoshinosuke
Y
Tanaka
Toshio
T
Taniguchi
Makoto
M
D000818:Animals; D000968:Antimycin A / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000378:metabolism; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013552:Swine
D007783:Lactones; D011725:Pyridines; D017382:Reactive Oxygen Species; C101439:UK 2A; D000968:Antimycin A