Oncogenic kinase signaling in human neoplasms.
Oncogenic proteins participate in cellular functions that involve transduction of signals from the extracellular environment, through the membrane, into the cytoplasm towards the nucleus, where transcription is initiated to generate proteins that will eventually contribute to the oncogenic phenotype. The wild-type homologues of cellular oncoproteins (proto-oncoproteins) frequently participate in signal transduction mechanisms that regulate cell and tissue homeostasis. Deregulation of proto-oncoprotein expression or function results in altered cellular signaling, oncogenic transformation, and inhibition of apoptosis. Oncogenic signals initiated from mutant proteins can override endogenous homeostasis control mechanisms such as anoikis and apoptosis and result in anchorage-independent growth, uncontrolled proliferation, and metastasis.
Tsatsanis
Christos
C
University of Crete School of Medicine, P.O. Box 2208, 71003 Heraklion, Crete, Greece.
Spandidos
Demetrios A
DA
D023102:Anoikis; D017209:Apoptosis; D002467:Cell Nucleus / Q000378:metabolism; D049109:Cell Proliferation; D003593:Cytoplasm / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology*; D010766:Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D015398:Signal Transduction
D011518:Proto-Oncogene Proteins; D010770:Phosphotransferases