The parasitophorous vacuole membrane of Encephalitozoon cuniculi lacks host cell membrane proteins immediately after invasion.
Microsporidia of the genus Encephalitozoon develop inside a parasitophorous vacuole (PV) of unknown origin. Using colocalization studies, the PV was found to be absent from the endocytic pathway markers early endosomal autoantigen 1, transferrin receptor, and lysosome-associated membrane protein 1 and for the endoplasmic reticulum marker calnexin. The nonfusiogenic characteristic of the PV appears to be acquired as early as 1 min postinfection and is not reversed by drug treatment with albendazole or fumagillin.
Fasshauer
Verena
V
Institute of Medical Microbiology, University of Göttingen, Göttingen, Germany.
Gross
Uwe
U
Bohne
Wolfgang
W
D015766:Albendazole / Q000494:pharmacology; D000818:Animals; D037281:Calnexin / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism*; D003510:Cyclohexanes; D009670:Encephalitozoon cuniculi / Q000737:chemistry* / Q000378:metabolism / Q000472:pathogenicity; D004705:Endocytosis; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D005347:Fibroblasts / Q000469:parasitology; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry; D051379:Mice; D008858:Microscopy, Phase-Contrast; D010587:Phagocytosis; D011990:Receptors, Transferrin / Q000378:metabolism; D012717:Sesquiterpenes; D013997:Time Factors
D003510:Cyclohexanes; D005231:Fatty Acids, Unsaturated; D008565:Membrane Proteins; D011990:Receptors, Transferrin; D012717:Sesquiterpenes; D037281:Calnexin; C026211:fumagillin; D015766:Albendazole