Accumulation of copper in kidney of spontaneously hypertensive rats, a preliminary study.
Mineral levels such as Cu, Fe, Zn, Ca and Mg in organs of spontaneously hypertensive osteogenic disorder Shionogi rat (SHR-od) were compared with those of normotensive osteogenic disorder Shionogi rat (ODS). The effect of vitamin C deficiency was also examined for both strains. Cu levels in kidney of SHR-od increased to 2.2 times and 5.0 times that of ODS at 6-week old and 30-week old, respectively, although the effect of vitamin C deficiency was not observed in Cu levels of five organs examined. The effect of vitamin C deficiency appeared in the change in the other mineral levels almost similarly for both SHR-od and ODS rats at 30-week old; the decrease of Fe in liver, spleen and lung, whereas the increase of Zn in liver, Ca in heart and Mg in spleen, respectively.
Minakata
Kayoko
K
Department of Legal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. kminakat@hama-med.ac.jp
Kawai
Kaori
K
Horio
Fumihiko
F
Takeuchi
Hiroichi
H
Suzuki
Osamu
O
D000818:Animals; D003300:Copper / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D012016:Reference Values
D003300:Copper