Capillary physiology and drug delivery in central nervous system lymphomas.
To evaluate whether the chemosensitivity of primary central nervous system lymphomas to water-soluble drugs could result from improved drug delivery, we quantitatively assessed pharmacokinetic factors in seven patients. The capillary permeability surface product was found to be significantly increased in central nervous system lymphomas compared with glioblastoma multiforme, medulloblastomas, and metastases. Tumoral blood flow was significantly greater than in normal white matter. Our results suggest favorable pharmacokinetics to water- and lipid-soluble drugs in primary central nervous system lymphomas.
Warnke
Peter C
PC
Department of Neurological Science, University of Liverpool, Clinical Sciences Centre for Research and Education, Lower Lane, Fazakerley, Liverpool L9 7LJ, Merseyside, United Kingdom. warnke@liverpool.ac.uk
Timmer
Jens
J
Ostertag
Christoph B
CB
Kopitzki
Klaus
K
D000328:Adult; D000368:Aged; D001931:Brain Mapping; D002196:Capillaries / Q000503:physiopathology*; D016543:Central Nervous System Neoplasms / Q000098:blood supply / Q000503:physiopathology*; D003287:Contrast Media / Q000008:administration & dosage; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007479:Iopamidol / Q000008:administration & dosage; D008223:Lymphoma / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D012039:Regional Blood Flow / Q000502:physiology*; D014057:Tomography, X-Ray Computed / Q000379:methods
D003287:Contrast Media; D007479:Iopamidol