Mouth metastasis of peripheral primitive neuroectodermal tumor.
We describe a case of oral metastasis of peripheral primitive neuroectodermal tumor (pPNET) in a 68-year-old man, who presented the primary lesion in the chest. Oral metastasis of pPNETs is very rare and we have not found any similar case reported in the English literature. Clinical examination showed an extensive and ulcerated fleshy mass measuring 3.0 x 3.5 cm in the right lower gingivae. Microscopic examination showed sheets of proliferating small, hyperchromatic, round cells. Tumor cells were reactive to neuron-specific enolase (NSE), vimentin and MIC-2 gene by immunohistochemistry, consistent with PNET. The patient died 3 weeks later because of respiratory insufficiency.
Pereira
C M
CM
Oral Pathology, School of Dentistry of Piracicaba, UNICAMP, São Paulo, Brazil. claudiomaranhao@hotmail.com
de Abreu Alves
F
F
Corrêa
M E P
ME
Lima
C S P
CS
de Almeida
O P
OP
D000368:Aged; D017809:Fatal Outcome; D005887:Gingival Neoplasms / Q000556:secondary*; D006801:Humans; D008297:Male; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology*