A case of Wegener's granulomatosis with pulmonary bleeding successfully treated with double filtration plasmapheresis (DFPP).
We report a case of a 41-year-old Japanese man who presented with rapidly progressive glomerulonephritis, chronic sinusitis, and positive cytoplasmic-antineutrophil cytoplasmic antibody (c-ANCA). Renal biopsy showed crescentic glomerulonephritis, and he was diagnosed as having Wegener's granulomatosis. During the clinical course, he suffered from pulmonary bleeding, and combination therapy of steroid, immunosuppressant, and double filtration plasmapheresis (DFPP) was started. He rapidly entered remission after assistance through DFPP, suggesting the potential efficacy of DFPP for Wegener's granulomatosis, especially with pulmonary bleeding.
Iwatani
Hirotsugu
H
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine (A8), 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. iwatani@medone.med.osaka-u.ac.jp
Uzu
Takashi
T
Kakihara
Masahiro
M
Nakayama
Yuji
Y
Kanasaki
Keizo
K
Yamato
Masaya
M
Hirai
Yasuhiro
Y
Umimoto
Koichi
K
Yamauchi
Atsushi
A
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008168:Lung / Q000098:blood supply / Q000473:pathology*; D008297:Male; D015523:Maxillary Sinusitis / Q000209:etiology / Q000473:pathology; D010956:Plasmapheresis; D011239:Prednisolone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D019268:Antibodies, Antineutrophil Cytoplasmic; D011239:Prednisolone