[The association between gingival cervicular fluid Interleukin-6 level, serum estradiol status and periodontitis in Uyghur postmenopausal women].
OBJECTIVE
The purpose of this investigation was to analyze by cross-sectional design the association between GCF IL-6 level, serum E2 level and common clinical measurements of periodontitis in Uyghur postmenopausal women.


METHODS
79 subjects within 5 years after menopause were enrolled in the study. 30 GCF samples were harvested from healthy sites, 49 GCF samples from chronic periodontitis sites. Clinical measurements of each tooth were recorded after obtaining GCF samples. GCF IL-6 and serum E2 levels were measured by radioimmunoassay (RIA).


RESULTS
The mean concentration of GCF IL-6 from healthy sites was (1088.10+/-102.33)pg/ml.The mean concentration of IL-6 from chronic periodontitis sites was significantly higher than that of healthy sites (P<0.005). Positive correlation was found between GCF IL-6 level and clinical measurements (GI, PPD and CAL) (r=0.564, P<0.005; r=0.335, P<0.05; r=0.324, P<0.05). Clinical measurements and GCF IL-6 levels of chronic periodontitis subjects were not different between E2-deficient and E2-sufficient subjects.


CONCLUSIONS
These findings suggest that there is lower IL-6 level in GCF from healthy sites; the increasing production of IL-6 may be associated with the initiation and progress of periodontitis. IL-6 may be a valuable indicator of the severity of periodontitis; E2 level is not associated with clinical measurements and GCF IL-6 level of chronic periodontitis of Uyghuy woman in early menopause.
Ha
Li-ya
LY
Department of Stomatology, The First Affiliated Hospital, Xinjiang Medical University, Wulumuqi 830054, Xinjiang, China. haliya2001@hotmail.com
A
Da-lat
DL
Zhong
Liang-jun
LJ
Feng
Jin-hong
JH
D003430:Cross-Sectional Studies; D004958:Estradiol / Q000097:blood*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D010518:Periodontitis / Q000453:epidemiology* / Q000378:metabolism; D017698:Postmenopause / Q000378:metabolism
D015850:Interleukin-6; D004958:Estradiol