title: Transcatheter closure of congenital ventricular septal defects in 3 dogs with a detachable coil.
abstract: The purpose of this study was to evaluate the feasibility, safety, and efficacy of transcatheter closure in dogs with a congenital perimembranous ventricular septal defect (VSD) by using a detachable coil. No dogs showed any symptoms, and results of chest X-rays and ECGs were normal. The diameters of VSD ranged from 2 to 4 mm on echocardiogram. The defect was 2-2.5 mm from the aortic valve. A detachable coil (size 5 mm with 5 loops) designed for patent ductus arteriosus was delivered via the transarterial route. The device was successfully employed in all dogs. A minimal residual shunt was observed in all dogs even though Qp/Qs decreased. Hemolysis and a rate-dependent right-bundle branch block were observed in 1 dog, but there was no clinical significance. No major complication was noted. Pathologic examination after 1 year revealed that the coils were covered with tissue without significant damage to the His-Purkinje conduction system. In conclusion, transcatheter closure of a small perimembranous VSD with a detachable coil can be achieved without major complications or significant pathologic damage at the lesion site.
authors.affiliation: Department of Surgery, Azabu University, Kanagawa, Japan. fujiiy@azabu-u.ac.jp
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujii
authors.forename: Takuya
authors.initials: T
authors.lastname: Fukuda
authors.forename: Noboru
authors.initials: N
authors.lastname: Machida
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yamane
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Wakao
mesh_terms: D000818:Animals; D006328:Cardiac Catheterization / Q000295:instrumentation / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D004285:Dogs; D004562:Electrocardiography / Q000662:veterinary; D006345:Heart Septal Defects, Ventricular / Q000628:therapy / Q000662:veterinary*; D008297:Male; D019919:Prosthesis Implantation / Q000662:veterinary; D011859:Radiography; D016896:Treatment Outcome; D014463:Ultrasonography