[Secondary chromosomic changes in patients with chronic myeloid leukemia in a reference hospital in Northeastern Mexico].
BACKGROUND
Our aim was to characterize the cytogenetic profile that displays a certain phase of chronic myelogenous leukemia (CML), offering new directions for investigation of the etiology to the molecular level. In Mexico, data does not exist in this regard; thus, the objective of the present study was to determine cytogenetic alterations in 56 Mestizo Mexican patients with LMC.


METHODS
Cross-sectional study (diagnosis and stage) was carried out.


METHODS
samples of bone marrow of 56 patients with CML in different phases were analyzed using G banding and fluorescence in situ hybridization (FISH) with DNA probes for Philadelphia chromosome (Ph).


RESULTS
19% of patients in chronic stage showed secondary chromosomal alterations in contrast with an observed 60% in patients in accelerated stage. Most frequent alterations included trisomy 8 and 19, extra Ph chromosome, and isochromosome of the 17.


CONCLUSIONS
We believe this to be the first work that determines secondary chromosomal alterations in Mexican racially mixed patients with LMC. These are in agreement with those reported for other populations at the worldwide level.
Dávila-Rodríguez
Martha I
MI
División de Genética, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Monterrey, México. marthadavila40@hotmail.com
Cerda-Flores
Ricardo M
RM
Leal-Garza
Carlos H
CH
Arana-Trejo
Rosa M
RM
Báez-de la Fuente
Enrique
E
Cortés-Gutiérrez
Elva I
EI
D000293:Adolescent; D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D003430:Cross-Sectional Studies; D005260:Female; D006761:Hospitals; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D012017:Referral and Consultation