Incidence and outcome of congenital cytomegalovirus infection in selected groups of preterm and full-term neonates under intensive care.
Congenital cytomegalovirus (CMV) infection is the leading cause of mental retardation and hearing impairment. Examination for the presence of CMV infection was carried out in a selected population of 70 neonates. Urine samples were tested for CMV by means of a nested polymerase chain reaction. CMV was detected in 6 (16.7%) of the 36 preterm newborns and in 5 (14.7%) of the 34 full-term newborns. One preterm neonate died and the remaining 10 newborns were followed up. Two children born at full-term did not excrete CMV at 2 years of age and were symptom-free. Of 8 CMV-excreting children (5 preterm and 3 full-term), 2 were symptom-free (1 preterm and 1 term). Symptomatic CMV disease developed in 6 children (4 preterm and 2 full-term), with mental retardation (n=4), hearing loss (n=1), strabismus (n=2) or bronchial asthma (n=1). Screening of such neonates is important; those identified as congenitally CMV-infected can be monitored to correct any sequelae immediately.
Nagy
Aranka
A
Department of Paediatrics, Faculty of Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Centre, University of Szeged, Hungary.
Endreffy
Emöke
E
Streitman
Károly
K
Pintér
Sándor
S
Pusztai
Rozália
R
D000328:Adult; D001249:Asthma / Q000453:epidemiology / Q000821:virology; D003422:Critical Care; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital* / Q000401:mortality; D005260:Female; D005865:Gestational Age; D034381:Hearing Loss / Q000453:epidemiology / Q000821:virology; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000821:virology*; D018445:Infectious Disease Transmission, Vertical; D008607:Intellectual Disability / Q000453:epidemiology / Q000821:virology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000821:virology*; D016036:Seroepidemiologic Studies; D013285:Strabismus / Q000453:epidemiology / Q000821:virology; D015996:Survival Rate; D016482:Urinalysis / Q000379:methods; D014556:Urine / Q000821:virology