Oligonucleotides and oligonucleotide conjugates: a new approach for cancer treatment.
In this account we summarise recent studies on oligonucleotides and oligonucleotide derivatives and their utilisation in antigene, antisense and decoy approaches, with particular attention to peptide nucleic acids, locked nucleic acids and oligonucleotide conjugates, the most promising compounds in this field.
Da Ros
Tatiana
T
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Trieste, Piazzale Europa 1, I-34127 Trieste, Italy.
Spalluto
Giampiero
G
Prato
Maurizio
M
Saison-Behmoaras
Tula
T
Boutorine
Alexandre
A
Cacciari
Barbara
B
D024221:Antineoplastic Protocols; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006801:Humans; D008968:Molecular Conformation; D009369:Neoplasms / Q000188:drug therapy*; D009696:Nucleic Acids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D009841:Oligonucleotides / Q000737:chemistry / Q000627:therapeutic use*; D016376:Oligonucleotides, Antisense / Q000737:chemistry / Q000627:therapeutic use
D003432:Cross-Linking Reagents; D009696:Nucleic Acids; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense