title: Thallium-201 SPECT in the evaluation of early effects on brain tumors treated with stereotactic irradiation.
abstract: OBJECTIVE
  To determine whether thallium-201 SPECT can predict response to stereotactic irradiation (STI) earlier than magnetic resonance imaging (MRI), the change in tumor size measured by MRI was compared with the change in tumor activity measured by Tl-201 SPECT before and after STI.
  
  
  METHODS
  Twenty-one tumors in 16 patients with intracranial tumors were treated by STI. Tl-201 SPECT was performed within 1 week before the beginning of STI and within 1 week after the end of STI in all patients. All patients underwent MRI within 1 week before the beginning of STI, and 14 patients (19 tumors) underwent MRI within 1 week after the end of STI. Follow-up MRI was performed 1 to 2 months after the end of STI in 14 patients (16 tumors). The activity of Tl-201 in the tumor divided by that of the uninvolved symmetric area was defined as the Tl-index. The change in tumor size immediately and 1 to 2 months after STI was compared with the change in Tl-index immediately after STI.
  
  
  RESULTS
  No significant relationship between the ratio of tumor size immediately after STI and the ratio of Tl-index immediately after STI was found. A significant correlation (r = 0.69, P <0.05) between the ratio of tumor size 1 to 2 months after STI and the ratio of Tl-index immediately after STI was found.
  
  
  CONCLUSIONS
  This study suggests that Tl-201 SPECT immediately after STI can predict treatment response 1 to 2 months after STI, and that Tl-201 SPECT can be an early indicator of treatment response.
authors.affiliation: Department of Radiology, Akita University School of Medicine, Akita, Japan. tomura@med.akita-u.ac.jp
authors.forename: Noriaki
authors.initials: N
authors.lastname: Tomura
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Izumi
authors.forename: Akira
authors.initials: A
authors.lastname: Anbai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Sakuma
authors.forename: Koichi
authors.initials: K
authors.lastname: Omachi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kidani
authors.forename: Kazuhumi
authors.initials: K
authors.lastname: Sasaki
authors.forename: Jiro
authors.initials: J
authors.lastname: Watarai
authors.forename: Akira
authors.initials: A
authors.lastname: Suzuki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mizoi
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009367:Neoplasm Staging / Q000379:methods; D011182:Postoperative Care / Q000379:methods; D011379:Prognosis; D019275:Radiopharmaceuticals; D016634:Radiosurgery / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013793:Thallium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; C027549:thallium chloride; D013793:Thallium