Reliability of urinary tests for antibody to Helicobacter pylori in patients with pulmonary tuberculosis.
OBJECTIVE
Although the quality of currently available urinary tests for detecting antibody to Helicobacter pylori (H pylori) have been proved in some populations, the accuracy has not been studied regarding patients who suffer from pulmonary tuberculosis with multi-drug treatments. The present study was conducted to evaluate the accuracy of these urinary tests for antibody to H pylori in these patients.


METHODS
Serum samples from 61 inpatients with pulmonary tuberculosis were tested using enzyme immunoassay, and urine samples were assayed by enzyme-linked immunosorbent assay method (URINELISA) and immunochromatography method (RAPIRAN). Medicines prescribed to the patients were recorded for medical charts, to evaluate the influences on the results of urinary tests.


RESULTS
The sensitivity, specificity, and consistency of URINELISA against the serum test were 93.1%, 65.6%, and 78.6% respectively, and those of RAPIRAN were 86.2%, 93.7%, and 90.1% respectively, which were almost equal to the data previously reported. Prescribed medicines had little influence on the results.


CONCLUSIONS
The two urinary tests for detecting H pylori antibody have a diagnostic accuracy in patients with pulmonary tuberculosis given multiple anti-tuberculosis drugs.
Yamamoto
Takatsugu
T
Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8606, Japan. kuyama@med.teikyo-u.ac.jp
Ishii
Taro
T
Kawakami
Tomotaka
T
Sase
Yoko
Y
Horikawa
Chiaki
C
Aoki
Nozomu
N
Sanaka
Masaki
M
Kuyama
Yasushi
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000652:urine*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000188:drug therapy*; D014556:Urine / Q000382:microbiology
D000995:Antitubercular Agents