Antibacterial constituents from the berries of Piper nigrum.
Piper nigrum finds an extensive application in antibacterial preparations belonging to Ayurvedic system of medicine. A bioguided extraction and fractionation of the petroleum ether extract of the berries of P. nigrum afforded 2E, 4E, 8Z-N-isobutyleicosatrienamide (1), pellitorine (2), trachyone (3), pergumidiene (4) and isopiperolein B (5). Pergumidiene and trachyone are isolated for the first time from P. nigrum. All the isolated compounds were active against Bacillus subtilis, Bacillus sphaericus, and Staphylococcus aureus amongst Gram + ve bacteria, and Klebsiella aerogenes and Chromobacterium violaceum among Gram -ve bacterial strains.
Reddy
S Venkat
SV
Natural Product Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Srinivas
Pullela V
PV
Praveen
B
B
Kishore
K Hara
KH
Raju
B China
BC
Murthy
U Suryanarayana
US
Rao
J Madhusudana
JM
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects; D002861:Chromobacterium / Q000187:drug effects; D021902:Enterobacter aerogenes / Q000187:drug effects; D029222:Piper nigrum / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D010936:Plant Extracts