title: Emergence of restless legs syndrome during subthalamic stimulation for Parkinson disease.
abstract: The authors systematically studied the emergence of restless legs syndrome (RLS) after subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson disease (PD). Postoperatively, 11 of 195 patients with STN DBS reported new problematic symptoms of RLS. The mean reduction in antiparkinsonian medication was 74%. The mean RLS score at diagnosis was 15 (+/-5.9) of a possible 24 points and after symptomatic drug therapy 4.3 (+/-3.1) points. Reduction of antiparkinsonian medication during STN DBS may unmask symptoms of RLS and complicate therapy of both RLS and PD.
authors.affiliation: University of Colorado Health Sciences Center, Denver, USA.
authors.forename: S
authors.initials: S
authors.lastname: Kedia
authors.forename: E
authors.initials: E
authors.lastname: Moro
authors.forename: M
authors.initials: M
authors.lastname: Tagliati
authors.forename: A E
authors.initials: AE
authors.lastname: Lang
authors.forename: R
authors.initials: R
authors.lastname: Kumar
mesh_terms: D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020189:Nocturnal Myoclonus Syndrome / Q000150:complications / Q000503:physiopathology; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D017286:Polysomnography; D012148:Restless Legs Syndrome / Q000209:etiology* / Q000503:physiopathology; D020531:Subthalamic Nucleus / Q000503:physiopathology*
chemical_list: D000978:Antiparkinson Agents; D018491:Dopamine Agonists; D007980:Levodopa