Pathological study of bronchospasms/tracheomalasia in patients with severe motor and intellectual disabilities.
This report concerns two autopsy cases of severe motor and intellectual disabilities (SMID) who died of bronchospasms or tracheomalasia. One case had no anatomical change in the tracheal wall except for an endotracheal granuloma, while the other showed softening of the tracheal wall. Since patients with SMID have risk factors for bronchospasms and tracheomalasia, such as gastro-esophageal reflux, aspiration, and thoracic deformities, it is important that we suspect the possibility of these conditions, when we see the respiratory distress in cases of SMID.
Ohtsuka
Eiko
E
Department of Pediatrics, Metropolitan Fuchu Medical Center for Severe Motor and Intellectual Disabilities, 2-9-2, Musashidai, Fuchu-shi, Tokyo 183-0042, Japan. eitsuru@yahoo.co.jp
Hayashi
Masaharu
M
Hamano
Kimiko
K
Kumada
Satoko
S
Uchiyama
Akira
A
Kurata
Kiyoko
K
Osawa
Makiko
M
D000328:Adult; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D001986:Bronchial Spasm / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D017809:Fatal Outcome; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006099:Granuloma / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009069:Movement Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D009421:Nervous System Malformations / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D011015:Pneumonia, Aspiration / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D013577:Syndrome; D014132:Trachea / Q000473:pathology* / Q000503:physiopathology