Fish and lifestyle-related disease prevention: experimental and epidemiological evidence for anti-atherogenic potential of taurine.
1. Taurine supplementation attenuated the development of hypertension and stroke in stroke-prone spontaneously hypertensive rats (SHRSP). 2. WHO-CARDIAC (Cardiovascular Diseases Alimentary Comparison) study revealed wide differences in 24-h urinary taurine excretion, which were inversely associated with age-adjusted mortality rates of coronary heart diseases (CHD). 3. Hypercholesterolemia as well as arterial fat deposition related to the cause of CHD was attenuated by dietary taurine supplementation in SHRSP on high-fat cholesterol diet. 4. Taurine affected the gene expression of 7alpha-hydroxylase and thus regulated serum cholesterol level through the control of the rate limiting step of cholesterol excretion into bile acids. 5. Taurine attenuated atherogenesis due to the control of oxidative stress through the inhibition of the production of oxidative LDL and to its scavenger effect on hypochlorous acid (HOCl) from leucocytes and macrophages. 6. Taurine may act as an immunomodulator of cytokine production, which is involved in atherogenesis.
Yamori
Yukio
Y
International Center for Research on Primary Prevention of Cardiovascular Diseases, Mukogawa Women's University, Nishinomiya, Japan. yamori@cardiacstudy.com
Murakami
Shigeru
S
Ikeda
Katsumi
K
Nara
Yasuo
Y
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D050197:Atherosclerosis / Q000378:metabolism / Q000517:prevention & control*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics; D003327:Coronary Disease / Q000453:epidemiology / Q000652:urine; D004032:Diet; D005399:Fishes; D015870:Gene Expression; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy; D007155:Immunologic Factors / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D008019:Life Style; D012333:RNA, Messenger / Q000378:metabolism; D011973:Receptors, LDL / Q000378:metabolism; D013654:Taurine / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
D000975:Antioxidants; D007155:Immunologic Factors; D012333:RNA, Messenger; D011973:Receptors, LDL; D013654:Taurine; D002790:Cholesterol 7-alpha-Hydroxylase