Comparison of ventricular long-axis function in patients with cardiac amyloidosis versus idiopathic restrictive cardiomyopathy.
To investigate ventricular long-axis function in cardiac amyloidosis (CA) and idiopathic restrictive cardiomyopathy (IRC), 16 patients with CA and 14 with IRC were studied. Left ventricular (LV) long-axis function was depressed in all patients with CA compared with only 36% of patients with IRC. Impairment in longitudinal function was clearly evident, even if fractional shortening and LV filling were normal. Ventricular long-axis function may be used as a sensitive marker of early systolic dysfunction. CA and IRC have quite distinct pathophysiologic profiles, raising some concerns about the appropriateness of considering them as 2 subtypes of a single nosographic entity.
Perugini
Enrica
E
The Royal Brompton Hospital, London, United Kingdom. e_perugini@hotmail.com <e_perugini@hotmail.com>
Rapezzi
Claudio
C
Reggiani
Letizia Bacchi
LB
Poole-Wilson
Philip
P
Branzi
Angelo
A
Henein
Michael Y
MY
D000686:Amyloidosis / Q000150:complications / Q000503:physiopathology*; D009202:Cardiomyopathies / Q000150:complications / Q000503:physiopathology*; D002313:Cardiomyopathy, Restrictive / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D016277:Ventricular Function, Left