[Metastasis tumors of the central nervous system: molecular biology].
Metastases in the nervous system represent an important and growing problem in the clinical practice, being the cause of a great mortality in the developed countries. This article reviews the few data available on the molecular mechanisms involved in the pathogenesis of these tumours, leading to oncogene activation, inactivation of tumour suppressor genes, not only by the classical mechanisms, but also by the tumour cell epigenetic balance alteration. We conclude that all this knowledge will lead in the future to a better diagnosis, treatment and clinic evolution of these patients.
Bello
M Josefa
MJ
Laboratorio de Oncogenética Molecular y Epigenética del Cáncer, Unidad de Investigación, Departamento de Cirugía Experimental, Hospital Universitario La Paz, Madrid, España.
González-Gómez
P
P
Rey
J A
JA
D016543:Central Nervous System Neoplasms / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008967:Molecular Biology; D009362:Neoplasm Metastasis / Q000235:genetics