title: TiCl4-promoted multicomponent reaction: a new entry to functionalized alpha-amino acids.
abstract: TiCl(4)-promoted multicomponent reactions involving N-tosyl imino ester, cyclic enol ether, and silane reagents in a single one-pot operation provide functionalized alpha-amino acids with multiple stereogenic centers in good to excellent yields. Cis/trans selectivities with optically active substituted dihydrofurans have been investigated.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA. arunghos@uic.edu
authors.forename: Arun K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: Chun-Xiao
authors.initials: CX
authors.lastname: Xu
authors.forename: Sarang S
authors.initials: SS
authors.lastname: Kulkarni
authors.forename: Donald
authors.initials: D
authors.lastname: Wink
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D014025:Titanium / Q000737:chemistry*
chemical_list: D000596:Amino Acids; C025096:titanium tetrachloride; D014025:Titanium