title: Two-dimensional MR spectroscopic characterization of breast cancer in vivo.
abstract: The major goal of this work was to characterize invasive ductal carcinoma and healthy fatty breast tissues noninvasively using the classification and regression tree analysis (CART) of 2D MR spectral data. 2D L-COSY spectra were acquired in 14 invasive breast carcinoma and 21 healthy fatty breasts using a GE 1.5 Tesla MRI/MRS scanner equipped with a 2-channel phased-array breast MR coil. The 2D spectra were recorded in approximately 10 minutes using a minimum voxel size of 1 ml without any water suppression technique. For healthy breasts, spectra were acquired from at least one fatty region. 2D L-COSY spectra were recorded in a total of 43 voxels. Five diagonal and six cross peak volumes were integrated and at least eighteen ratios were selected as potential features for the statistical method, namely CART. The 2D L-COSY data showed a significant increase for the majority of these ratios in invasive breast carcinomas compared to healthy fatty tissues. Better accuracy of identifying carcinomas and fatty tissues is reported using CART analysis of different combinations of ratios calculated from the relative levels of water, choline, and saturated and unsaturated lipids. This is a first report on the statistical classification of 2D L-COSY in human breast carcinomas in vivo.
authors.affiliation: Radiological Sciences, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095-1721, USA. athomas@mednet.ucla.edu
authors.forename: M Albert
authors.initials: MA
authors.lastname: Thomas
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Wyckoff
authors.forename: Kenneth
authors.initials: K
authors.lastname: Yue
authors.forename: Nader
authors.initials: N
authors.lastname: Binesh
authors.forename: Shida
authors.initials: S
authors.lastname: Banakar
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Chung
authors.forename: James
authors.initials: J
authors.lastname: Sayre
authors.forename: Nanette
authors.initials: N
authors.lastname: DeBruhl
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D009367:Neoplasm Staging