Isolated small bowel transplantation from a living-related donor at the Catholic University of Korea--a case report of rejection -free course-.
The bowel transplantation team at the Catholic Medical Center, Korea, on April 9 2004, accomplished a case of isolated small bowel transplantation (SBT) in a 57 year-old female with short bowel syndrome. The primary surgery was a jejunocolostomy due to mesenteric vein thrombosis, while maintaining 30 cm of the jejunum and colon distal to the splenic flexure. Her renal function was partially unbalanced. During more than 2 years of home TPN, the superior vena cava (VC) and subclavian veins had become occluded, but the inferior VC line remained. SBT was planned due to the repeated life-threatening infections of the last central line. One hundred and fifty centimeter of the distal ileum of the 27 year-old living-related donor, the patient's daughter, was harvested. The graft mesenteric artery and vein were anastomosed to the recipient's inferior mesenteric vessels. A proximal end-to-end jejuno-ileostomy and a distal end-to-side ileo-colostomy of the graft were made, creating a Bishop-Koop enterostomy for graft surveillance. A tube jejunostomy, via a gastrostomy, was established for early feeding and simultaneous gastric drainage. Induction with Daclizumab and immunosuppression consisted of tacrolimus and methylprednisolone, given intravenously, and then mycophenolate mofetil (MMF), enterally from day 3. The patient was discharged on day 42. A CMV infection on day 83 was successfully treated with 3 weeks of gancyclovir therapy. She has been nutritionally independent, with complete oral feeding, and free of rejection until day 170 after the transplantation.
Lee
Myung Duk
MD
Department of Surgery, Organ Transplantation Center of the Catholic Medical Center, Kangnam St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea. Lmyungd@catholic.ac.kr
Kim
Dong Goo
DG
Ahn
Sang Tae
ST
Moon
In Sung
IS
Choi
Myung Gyu
MG
Hong
Seok Gi
SG
Park
Sun Cheol
SC
Chung
In Sik
IS
Choi
Jong Young
JY
Yoon
Seung Kew
SK
Kim
Sang Il
SI
Choi
Jong Ho
JH
Jung
Eun Sun
ES
D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007421:Intestine, Small / Q000637:transplantation*; D007723:Korea; D019520:Living Donors; D008642:Mesenteric Veins; D008875:Middle Aged; D011182:Postoperative Care; D011859:Radiography; D012778:Short Bowel Syndrome / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications