title: Evaluation of immunogenicity and side effects of triple viral vaccine (MMR) in adults, given by two routes: subcutaneous and respiratory (aerosol).
abstract: Adult volunteers from two neighboring health centers were immunized with measles, mumps, rubella vaccine (MMR, Serum Institute of India Ltd.), either given by traditional injections or by an aerosol delivered to the respiratory tract. Baseline and one month post vaccination samples were taken and simultaneously assayed for all three antigens. Subjects were followed-up for temporally associated events after vaccination. The aerosol route was superior for measles, mumps and rubella when baseline titers were controlled for in multivariate analysis. Frequencies of post-vaccination events did not differ with statistical significance between the groups. Further evaluation of the aerosol route for MMR immunization appears warranted.
authors.affiliation: National Institute of Public Health, Av. Universidad 655, Col. Sta. Maria, Ahuacatitian C.P. 62508, Cuernavaca, Mexico.
authors.forename: Jorge Fernandez de
authors.initials: JF
authors.lastname: Castro
authors.forename: John V
authors.initials: JV
authors.lastname: Bennett
authors.forename: Hector Gallardo
authors.initials: HG
authors.lastname: Rincon
authors.forename: M T Alvarez Y
authors.initials: MT
authors.lastname: Munoz
authors.forename: Luis Alfonso E Partida
authors.initials: LA
authors.lastname: Sanchez
authors.forename: Jose Ignacio
authors.initials: JI
authors.lastname: Santos
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D008875:Middle Aged; D015999:Multivariate Analysis; D012220:Rhinitis / Q000139:chemically induced / Q000276:immunology; D012894:Sleep Stages / Q000187:drug effects / Q000276:immunology
chemical_list: D000336:Aerosols; D022542:Measles-Mumps-Rubella Vaccine