Plasma levels of antioxidants are not associated with Alzheimer's disease or cognitive decline.
Antioxidants prevent oxidative stress that possibly causes neuronal loss in Alzheimer's disease (AD). We examined whether high plasma levels of the antioxidant vitamins A and E were associated with lower prevalence of AD or cognitive decline (CD). We performed a cross-sectional study within the Rotterdam Study. In an univariate model, higher levels of vitamins A and E were significantly associated with lower prevalence of AD. However, when additional adjustments were made for important confounders, such as age, gender and total cholesterol, the relation substantially weakened -- odds ratios per standard deviation increase were 0.87 (95% CI 0.64-1.19) for vitamin A and 0.94 (95% CI 0.60-1.48) for vitamin E. Antioxidants were not related to CD in non-demented subjects. Our findings suggest no association between plasma levels of vitamin A and E and AD or CD.
Engelhart
Marianne J
MJ
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
Ruitenberg
Annemieke
A
Meijer
John
J
Kiliaan
Amanda
A
van Swieten
John C
JC
Hofman
Albert
A
Witteman
Jacqueline C M
JC
Breteler
Monique M B
MM
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D000975:Antioxidants / Q000378:metabolism*; D003072:Cognition Disorders / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D016015:Logistic Models; D008297:Male; D008609:Mental Status Schedule; D009426:Netherlands; D016017:Odds Ratio; D011159:Population Surveillance; D011446:Prospective Studies; D013223:Statistics as Topic; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
D000975:Antioxidants; D014801:Vitamin A; D014810:Vitamin E