title: [Two cases of gastric cancers with lung metastases responding to weekly administration of paclitaxel].
abstract: We report two cases of gastric cancer with multiple lung metastases responding well to weekly administration for 3 weeks followed by a week discontinuation of paclitaxel (80 mg/m2). Case 1, a 73-year-old man, was diagnosed as multiple lung metastases 1 year and 4 months after total gastrectomy for Borrmann 1 type gastric cancer (7.5 x 6.5 cm, pap, P0 cy(-) H0 mpn2, stage III A, ly2, v2). After 8 weekly administrations of paclitaxel 110 mg (80 mg/m2), the lung tumor diminished from 5 cm to a linear scar in size, and dyspnea needing inhalation of oxygen at home disappeared. Case 2, another 73 year-old man with multiple lung metastases at 7 months after distal gastrectomy for Borrmann 3 type gastric cancer (4 x 3.5 cm, muc, P0 cy(-) H0 sen2, stage III B, ly1, v0) received weekly paclitaxel 110 mg (80 mg/m2). Lung tumors disappeared after 27 administrations of paclitaxel, and CT scans have showed CR for 8 months until now after 44 administrations. Therefore, we recommend weekly administration of paclitaxel for lung metastases from gastric cancer.
authors.affiliation: Dept. of Surgery, Kitakyushu Municipal Medical Center.
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Iwashita
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suehara
authors.forename: Keisei
authors.initials: K
authors.lastname: Anan
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Nishihara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Abe
authors.forename: Keiyoshi
authors.initials: K
authors.lastname: Tamae
authors.forename: Shoshu
authors.initials: S
authors.lastname: Mitsuyama
mesh_terms: D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005743:Gastrectomy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage*; D011788:Quality of Life; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel