Polymerase chain reaction in the management of disseminated adenovirus infection after stem cell transplantation.
We report a 20-month-old child with disseminated adenovirus infection after a haploidentical T cell-depleted stem cell transplantation. This case demonstrates the value of polymerase chain reaction surveillance for early detection of adenovirus infection and the role of quantitative polymerase chain reaction for monitoring antiviral therapy. It also emphasizes the importance of T cell immunity in controlling disseminated adenovirus infection after stem cell transplantation.
Walls
Tony
T
Academic Department of Child Health, Royal London Hospital, United Kingdom. t.m.walls@qmul.ac.uk
Hawrami
Khidir
K
Shingadia
Delane
D
Ushiro-Lumb
Ines
I
Shankar
Ananti
A
D000258:Adenovirus Infections, Human / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008212:Lymphocyte Depletion; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D016133:Polymerase Chain Reaction / Q000379:methods*; D013601:T-Lymphocytes / Q000276:immunology