[Roles of silencers from the regulatory region of the abdominal-B gene and the Zw5 and Su(Hw) insulators in regulating gene expression in Drosophila melanogaster].
A study was made of the functional role of silencers in the long-distance interaction between insulators. Transgenic lines containing the Su(Hw) and Zw5 insulators were analyzed. The silencers failed to efficiently suppress transcription of the yellow gene, nor did they neutralize the effect of the Su(Hw) insulator. The long-distance interaction between insulators was assumed to depend on the combined effects of silencers, insulators, and, possibly, some unidentified regulatory elements.
Kullyev
A P
AP
Savitskaia
E E
EE
Georgiev
P G
PG
Gruzdeva
N M
NM
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster; D005786:Gene Expression Regulation / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics*; D037941:Silencer Elements, Transcriptional / Q000235:genetics*
C062393:Abd-B proteins, Drosophila; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; C121540:dwg protein, Drosophila