Functionalized micellar assemblies prepared via block copolymers synthesized by living free radical polymerization upon peptide-loaded resins.
Hybrid peptidic-synthetic amphiphilic block copolymers, synthesized by living free radical polymerization (LFRP) on solid support, have been utilized as precursors for nanoscale materials possessing bio-available peptides. LFRP initiators, coupled to the peptide terminus upon the resin, facilitated the growth of homo- and block copolymers via nitroxide mediated radical polymerization (NMRP) or atom transfer radical polymerization (ATRP). Herein, the versatile solid-support synthesis of the antimicrobial peptide tritrpticin, coupling of living free radical polymerization initiators to the peptide-loaded resin, and the controlled radical polymerization of various monomers to yield amphiphilic diblock copolymers are described. Assembly of the peptidic-synthetic block copolymers into micelles and a preliminary assessment of their in vitro biological properties are detailed.
Becker
Matthew L
ML
Center for Materials Innovation and Department of Chemistry, Washington University, One Brookings Drive, St. Louis, Missouri 63130-4899, USA.
Liu
Jianquan
J
Wooley
Karen L
KL
D000595:Amino Acid Sequence; D005609:Free Radicals / Q000737:chemistry; D008823:Micelles; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis*; D012117:Resins, Synthetic / Q000138:chemical synthesis* / Q000737:chemistry
D005609:Free Radicals; D008823:Micelles; D010455:Peptides; D011108:Polymers; D012117:Resins, Synthetic