title: [Perspective of calcium antagonist].
abstract: L-type calcium channel antagonist is clinically used for treatment of cardiovascular diseases such as angina, hypertension and arrhythmia. Recent large clinical trials indicated that calcium antagonist is effective in the prevention of cardiovascular event as well as the treatment of hypertension. Recently, calcium antagonists, not stimulating sympathetic nerve activity, have been newly developed. In the future, clinical application of N-type or T-type calcium antagonist are expected.
authors.affiliation: Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Japan.
authors.forename: Shokei
authors.initials: S
authors.lastname: Kim-Mitsuyama
mesh_terms: D002121:Calcium Channel Blockers / Q000737:chemistry / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use; D015220:Calcium Channels / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000517:prevention & control; D015195:Drug Design; D006801:Humans; D013564:Sympathetic Nervous System / Q000187:drug effects
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels