title: Evaluation of the trypanocidal and leishmanicidal in vitro activity of the crude hydroalcoholic extract of Pfaffia glomerata (Amarathanceae) roots.
abstract: Three different concentrations (1, 10 and 50 microg/ml) of lyophilized hydroalcoholic crude extract of Pfaffia glomerata roots were assayed in vitro against strains of Trypanosoma cruzi (Y) and Leishmania braziliensis. It was observed that P. glomerata hydroalcoholic extract was relatively active within the tested concentrations for L. (V) braziliensis, but inactive against T. cruzi. Despite the fact that both protozoans belong to the Trypanosomatidae family, we suggest that the difference observed for activity should be related to the biological differences between the two parasite species.
authors.affiliation: Mestrando do Curso de Pós-Graduação Strictu Sensu em Promoção de Saúde, Universidade de Franca, Franca, SP, Brazil.
authors.forename: A G
authors.initials: AG
authors.lastname: Neto
authors.forename: A A
authors.initials: AA
authors.lastname: da Silva Filho
authors.forename: J M L C
authors.initials: JM
authors.lastname: Costa
authors.forename: A H C
authors.initials: AH
authors.lastname: Vinholis
authors.forename: G H B
authors.initials: GH
authors.lastname: Souza
authors.forename: W R
authors.initials: WR
authors.lastname: Cunha
authors.forename: M L A E
authors.initials: ML
authors.lastname: Silva
authors.forename: S
authors.initials: S
authors.lastname: Albuquerque
authors.forename: J K
authors.initials: JK
authors.lastname: Bastos
mesh_terms: D027703:Amaranthaceae / Q000737:chemistry*; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007892:Leishmania braziliensis / Q000187:drug effects*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D014344:Trypanocidal Agents / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts; D014344:Trypanocidal Agents