[Protein HLDF and antibodies to it as molecular pathogenetic factors and new markers of acute cerebral blood circulation disturbances].
Clinic-experimental complex investigation and ELISA determination of protein HLDF as also primary antibodies (Abs) to HLDF values in blood and cerebro-spinal fluid (CSF) of patients with hypertensive crises and acute aterotrombotic ischemic stroke were performed. Statistically improved difference in serum HLDF and Abs content in examined patients in comparison with age-matched controls as also significant intergroup's differences in protein and Abs dynamic content were determined. Correlation between content and dynamics of investigated factors in CSF and blood serum with determined clinical and instrumental parameters was revealed. Pathogenetic and prognostic significance of revealed changes in molecular factors was viewed.
Sherstnev
V V
VV
Skvortsova
V I
VI
Gruden'
M A
MA
Shirokov
E A
EA
Denshchuk
I S
IS
Iurasov
V V
VV
Elistratova
E I
EI
Iakovleva
N E
NE
Shetova
I M
IM
Kostanian
I A
IA
Gubskaia
O B
OB
D000208:Acute Disease; D000367:Age Factors; D000906:Antibodies / Q000097:blood / Q000134:cerebrospinal fluid; D015415:Biomarkers; D001921:Brain / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D002545:Brain Ischemia / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism; D002341:Carotid Artery Thrombosis / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*
D000906:Antibodies; D015415:Biomarkers; D009363:Neoplasm Proteins; C091149:cell differentiation factor 8.2-kDa