The influence of antineoplastic chemotherapy on the glutathione enzymes activity in the blood.
The analysis included 78 patients (42 men and 36 women) aged 48 to 67 years treated with cytostatics because of a neoplastic disease. In all the patients examined was evaluated the influence of the chemotherapy carried out on the glutathione peroxidase (GPx) and glutathione reductase (GR) activities. It was confirmed that the effect of the action on the glutathione enzymes (GE) activity of the antineoplastic chemotherapy changes depending on the duration of the treatment with cytostatics. In the end this activity settles at a high level, statistically significantly higher than that registered before the beginning of the antineoplastic treatment. The increase of the GE activity is mainly favoured by the chemotherapy following the schemes FAC (5-fluorouracyl + doxorubicin + endoxan) and PAC (cisplatin + cyclofosfamide + pharmorubicin).
Kopañski
Z
Z
Military Clinical Hospital, 1-3 Wrocławska str., 30-901 Kraków, Poland.
Grabowska
M
M
Kosiniak-Kamysz
A
A
Bertrandt
J
J
Kołodziejski
L
L
Opoka
W
W
Schlegel-Zawadzka
M
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000097:blood*; D005980:Glutathione Reductase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione