title: Exploring the relationships between inflammatory response and coagulation cascade in inflammatory bowel disease.
abstract: BACKGROUND
  The inflammatory network and the coagulation cascade are strictly correlated biological systems. Inflammatory Bowel Diseases (IBD) are characterised by a prothrombotic state, a hypercoagulability state and an increased prevalence of thromboembolic events.
  
  
  METHODS
  We reviewed the IBD literature in which the relationships between inflammation and coagulation were evaluated.
  
  
  RESULTS
  Several risk factors and mechanisms have been suggested to be implicated in determining the increased risk for thrombosis of IBD. Even if IBD may be per se a prothrombotic condition, systemic inflammation and vitamin deficiencies appear to play a relevant role in determining such a risk.
  
  
  CONCLUSIONS
  A good and continuous control of the intestinal disease and vitamin supplementation are strongly recommended in order to correct some of the risk factors for thrombosis in IBD patients.
authors.affiliation: Gastroenterology and Gastrointestinal Endoscopy Service, IRCCS Maggiore Hospital and University of Milan - Milan (Italy).
authors.forename: S
authors.initials: S
authors.lastname: Saibeni
authors.forename: L
authors.initials: L
authors.lastname: Spina
authors.forename: M
authors.initials: M
authors.lastname: Vecchi
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D001778:Blood Coagulation Disorders / Q000150:complications; D006801:Humans; D018836:Inflammation Mediators; D015212:Inflammatory Bowel Diseases / Q000097:blood* / Q000473:pathology*; D013927:Thrombosis / Q000150:complications
chemical_list: D018836:Inflammation Mediators