title: Karnatakafurans A and B: two dibenzofurans isolated from the Fungus Aspergillus karnatakaensis.
abstract: Karnatakafurans A (1) and B (2), two novel dibenzofurans, have been isolated from the Specie Novum Aspergillus karnatakaensis Frisvad. The compounds were the major secondary metabolites and were isolated through UV-guided fractionation of the organic extract. The structures were elucidated by spectroscopic methods including MS and NMR. The compounds were tested for antimicrobial and antimalarial activity and proved to be moderately active against Plasmodium falciparum.
authors.affiliation: Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Manniche
authors.forename: Kenneth
authors.initials: K
authors.lastname: Sprogøe
authors.forename: Petur W
authors.initials: PW
authors.lastname: Dalsgaard
authors.forename: Carsten
authors.initials: C
authors.lastname: Christophersen
authors.forename: Thomas O
authors.initials: TO
authors.lastname: Larsen
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D001572:Benzofurans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D001572:Benzofurans; C497403:karnatakafuran A; C497404:karnatakafuran B