title: Synthesis and antiviral evaluation of D4T analogues with a spacer arm between glucidic and base moieties.
abstract: The synthesis of a series of d4T analogues bearing an acyclic chains between the sugar and the base moities, is described. New compounds were obtained readily using microwave irradiation and selective deprotection of sugar part. The compounds were characterized by 1H NMR and IR spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.
authors.affiliation: Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Université de Limoges, Limoges, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Roy
authors.forename: Rachida
authors.initials: R
authors.lastname: Zerrouki
authors.forename: Pierre
authors.initials: P
authors.lastname: Krausz
authors.forename: Sylvie
authors.initials: S
authors.lastname: Schmidt
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Aubertin
mesh_terms: D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D018119:Stavudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D018894:Reverse Transcriptase Inhibitors; D018119:Stavudine