title: Multiple ground-glass opacity in metastasis of malignant melanoma diagnosed by lung biopsy.
abstract: Focal ground-glass opacity (GGO) on computed tomography has been reported in several disorders including inflammatory disease and primary neoplastic lesion of the lung. We report a case of malignant melanoma of the nasal cavity metastatic to the lungs in which multiple pulmonary nodules showed GGO. Lung biopsy specimen demonstrated melanoma cells proliferating in a lepidic fashion along the thickened alveolar wall simulating bronchioloalveolar carcinoma. Metastatic lung tumor showing GGO is uncommon.
authors.affiliation: Department of Surgery, National Shikoku Cancer Center Hospital, Matsuyama, Japan. rokita@hiroshima-u.ac.jp
authors.forename: Riki
authors.initials: R
authors.lastname: Okita
authors.forename: Motohiro
authors.initials: M
authors.lastname: Yamashita
authors.forename: Masao
authors.initials: M
authors.lastname: Nakata
authors.forename: Norihiro
authors.initials: N
authors.lastname: Teramoto
authors.forename: Akihiro
authors.initials: A
authors.lastname: Bessho
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mogami
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging; D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000000981:diagnostic imaging; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D003606:Dacarbazine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology* / Q000601:surgery; D009669:Nose Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D010844:Picibanil / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014498:Uracil / Q000008:administration & dosage
chemical_list: D018906:Antineoplastic Agents, Alkylating; D005641:Tegafur; D010844:Picibanil; D014498:Uracil; D003606:Dacarbazine