title: Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient mice.
abstract: The present study was aimed at investigating the role of gastrin in startle, startle habituation and prepulse inhibition (PPI). There were no significant differences between gastrin knockout mice and their wildtype controls in any of these baseline parameters. The disruption of PPI by treatment with 5 mg/kg of amphetamine was absent in gastrin knockout mice. However, a higher dose of amphetamine disrupted PPI in both genotypes. Similarly, treatment with the dopamine receptor agonist, apomorphine, the N-methyl-D-aspartate receptor antagonist, MK-801, and the serotonin-1A receptor agonist, 8-hydroxy-di-propylaminotetralin (8-OH-DPAT) modulated PPI similarly in gastrin knockout mice and wildtype controls. These data suggest a role of gastrin in the brain in modulating dopamine release in areas involved in PPI.
authors.affiliation: Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Vic. 3052, Australia. mvandenbuuse@mhri.edu.au
authors.forename: Maarten
authors.initials: M
authors.lastname: van den Buuse
authors.forename: Ian R
authors.initials: IR
authors.lastname: van Driel
authors.forename: Linda C
authors.initials: LC
authors.lastname: Samuelson
authors.forename: Meggie
authors.initials: M
authors.lastname: Pijnappel
authors.forename: Sally
authors.initials: S
authors.lastname: Martin
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology; D005260:Female; D005755:Gastrins / Q000096:biosynthesis / Q000172:deficiency* / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D013216:Reflex, Startle / Q000187:drug effects* / Q000502:physiology
chemical_list: D005755:Gastrins; D016291:Dizocilpine Maleate; D000661:Amphetamine