title: Thiobutacin, a novel antifungal and antioomycete antibiotic from Lechevalieria aerocolonigenes.
abstract: A novel butanoic acid, thiobutacin (1), 4-(2-aminophenyl)-4-oxo-2-methylthiobutanoic acid (C11H13NO3S), was isolated from the culture broth of a soil actinomycete, Lechevalieria aerocolonigenes strain VK-A9. The structure of thiobutacin (1) was elucidated on the basis of the extensive 2D NMR spectral data including 1H-1H COSY, HMBC, HMQC, ROESY, and NOESY. Thiobutacin (1) showed antioomycete and antifungal activity against phytopathogenic Phytophthora capsici and Botrytis cinerea and the yeast Saccharomyces cerevisiae.
authors.affiliation: Division of Bioscience and Technology, College of Life and Environmental Sciences, Korea University, Seoul 136-713, Korea.
authors.forename: Jung Yeop
authors.initials: JY
authors.lastname: Lee
authors.forename: Surk Sik
authors.initials: SS
authors.lastname: Moon
authors.forename: Bong Sik
authors.initials: BS
authors.lastname: Yun
authors.forename: Ick Dong
authors.initials: ID
authors.lastname: Yoo
authors.forename: Byung Kook
authors.initials: BK
authors.lastname: Hwang
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020171:Botrytis / Q000187:drug effects; D002087:Butyrates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D007723:Korea; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010838:Phytophthora / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D002087:Butyrates; C497177:thiobutacin