title: Synchronous transitional cell carcinoma and metastatic hepatocellular carcinoma in the urinary bladder: a case report.
abstract: An 83- year-old male presented with intermittent hematuria and obstructive symptoms. A CT scan of the abdomen and pelvis showed diffuse thickening of the urinary bladder and a large 10 cm liver mass. Histopathological examination of bladder biopsy demonstrated two distinct lesions. The surface showed non-invasive urothelial carcinoma and the submucosa demonstrated metastatic hepatocellular carcinoma showing bile pigment and expressed Hep Par 1 and CD10. To the best of our knowledge, this is the first case report of synchronous transitional cell carcinoma and metastatic hepatocellular carcinoma of the urinary bladder.
authors.affiliation: Department of Pathology, McMaster University, Henderson General Hospital, Hamilton, Ontario, Canada.
authors.forename: Nabeel
authors.initials: N
authors.lastname: Al-Brahim
authors.forename: Salem
authors.initials: S
authors.lastname: Alowami
authors.forename: Ian
authors.initials: I
authors.lastname: Davis
authors.forename: Dean
authors.initials: D
authors.lastname: Daya
mesh_terms: D000368:Aged; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000556:secondary*; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D006417:Hematuria / Q000209:etiology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000556:secondary*