title: Designing a prosthesis to simulate the elastic properties of skin.
abstract: The materials which are currently used to make maxillofacial prostheses are far from ideal and require considerable improvement with respect to their ability to mimic the properties of skin. To this aim, a novel three-layered maxillofacial prosthesis has been designed consisting of a silicone rubber base layer, an inner gel layer and an outer polymeric coating (to simulate the elastic properties of skin). The aim of the work in this study was to develop the inner silicone gel layer which displays similar properties to facial skin. Through the use of unique linear extensometry testing, in vivo measurements for the Area under the Curve (AUC), Hysteresis (viscoelastic behaviour), Fmax (maximum force), F30 and F60 (force after 30 and 60 seconds) were obtained from the facial skin of 15 volunteers. The results were used as a basis for developing silicone gel formulations for the inner layer, to closely resemble those of facial skin. Gels were made by the addition of both low and high molecular weight unreactive silicone fluids and were further tested for compression, water absorption and dehydration. Testing showed that a gel has been produced that closely simulates the elastic properties of skin when bonded to a base silicone rubber layer. Further testing will need to deduce whether these properties will be affected by the addition of the outer polymeric layer.
authors.affiliation: Department of Dental Health and Biological Sciences, University of Wales College of Medicine, Cardiff, UK.
authors.forename: K E
authors.initials: KE
authors.lastname: Bellamy
authors.forename: M G J
authors.initials: MG
authors.lastname: Waters
mesh_terms: D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry*; D040761:Biomimetic Materials / Q000032:analysis / Q000737:chemistry*; D019245:Compressive Strength; D004548:Elasticity; D006245:Hardness Tests / Q000379:methods; D006801:Humans; D008422:Materials Testing / Q000379:methods; D008447:Maxillofacial Prosthesis; D008970:Molecular Weight; D011474:Prosthesis Design / Q000379:methods*; D020034:Silicone Gels / Q000032:analysis / Q000737:chemistry*; D012879:Skin Physiological Phenomena; D017768:Skin, Artificial; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D020034:Silicone Gels; D014867:Water