title: Spontaneous ocular squamous cell carcinoma in twin goats: pathological and biomolecular studies.
abstract: Ocular squamous cell carcinoma (OSCC) is a well-characterized tumour occurring spontaneously in cattle and other mammalian species but not previously reported in the goat. This report describes the histological features of well-differentiated OSCCs in twin goats. Biomolecular investigations led to the identification of Papillomavirus-related DNA sequences within the neoplastic ocular parenchyma of both animals, but immunohistochemical and ultrastructural studies failed to demonstrate viral particles. A putative role of Papillomavirus in the aetiology of OSCC is discussed, together with other possible causative factors.
authors.affiliation: Department of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, University of Teramo, Piazza Aldo Moro 45, 64100 Teramo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Marà
authors.forename: G
authors.initials: G
authors.lastname: Di Guardo
authors.forename: A
authors.initials: A
authors.lastname: Venuti
authors.forename: G
authors.initials: G
authors.lastname: Marruchella
authors.forename: C
authors.initials: C
authors.lastname: Palmieri
authors.forename: M
authors.initials: M
authors.lastname: De Rugeriis
authors.forename: L
authors.initials: L
authors.lastname: Petrizzi
authors.forename: P
authors.initials: P
authors.lastname: Simeone
authors.forename: C
authors.initials: C
authors.lastname: Rizzo
authors.forename: L
authors.initials: L
authors.lastname: Della Salda
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D004279:DNA, Viral / Q000032:analysis; D005134:Eye Neoplasms / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D015511:Goat Diseases; D006041:Goats; D007124:Immunoenzyme Techniques / Q000662:veterinary; D008297:Male; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D014427:Twins
chemical_list: D004279:DNA, Viral