title: Selecton: a server for detecting evolutionary forces at a single amino-acid site.
abstract: We present an algorithmic tool for the identification of biologically significant amino acids in proteins of known three dimensional structure. We estimate the degree of purifying selection and positive Darwinian selection at each site and project these estimates onto the molecular surface of the protein. Thus, patches of functional residues (undergoing either positive or purifying selection), which may be discontinuous in the linear sequence, are revealed. We test for the statistical significance of the site-specific scores in order to obtain reliable and valid estimates.
  
  
  BACKGROUND
  The Selecton web server is available at: http://selecton.bioinfo.tau.ac.il
  
  
  BACKGROUND
  More information is available at http://selecton.bioinfo.tau.ac.il/overview.html. A set of examples is available at http://selecton.bioinfo.tau.ac.il/gallery.html.
authors.affiliation: Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Doron-Faigenboim
authors.forename: Adi
authors.initials: A
authors.lastname: Stern
authors.forename: Itay
authors.initials: I
authors.lastname: Mayrose
authors.forename: Eran
authors.initials: E
authors.lastname: Bacharach
authors.forename: Tal
authors.initials: T
authors.lastname: Pupko
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution / Q000235:genetics; D000596:Amino Acids / Q000737:chemistry* / Q000235:genetics*; D003196:Computer Graphics; D003198:Computer Simulation; D004252:DNA Mutational Analysis; D019143:Evolution, Molecular; D016333:HIV Protease / Q000737:chemistry / Q000235:genetics; D006801:Humans; D020407:Internet; D008957:Models, Genetic; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed / Q000235:genetics; D010802:Phylogeny; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D013329:Structure-Activity Relationship; D014584:User-Computer Interface
chemical_list: D000596:Amino Acids; D011506:Proteins; D016333:HIV Protease