title: Antibacterial constituents from the berries of Piper nigrum.
abstract: Piper nigrum finds an extensive application in antibacterial preparations belonging to Ayurvedic system of medicine. A bioguided extraction and fractionation of the petroleum ether extract of the berries of P. nigrum afforded 2E, 4E, 8Z-N-isobutyleicosatrienamide (1), pellitorine (2), trachyone (3), pergumidiene (4) and isopiperolein B (5). Pergumidiene and trachyone are isolated for the first time from P. nigrum. All the isolated compounds were active against Bacillus subtilis, Bacillus sphaericus, and Staphylococcus aureus amongst Gram + ve bacteria, and Klebsiella aerogenes and Chromobacterium violaceum among Gram -ve bacterial strains.
authors.affiliation: Natural Product Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: S Venkat
authors.initials: SV
authors.lastname: Reddy
authors.forename: Pullela V
authors.initials: PV
authors.lastname: Srinivas
authors.forename: B
authors.initials: B
authors.lastname: Praveen
authors.forename: K Hara
authors.initials: KH
authors.lastname: Kishore
authors.forename: B China
authors.initials: BC
authors.lastname: Raju
authors.forename: U Suryanarayana
authors.initials: US
authors.lastname: Murthy
authors.forename: J Madhusudana
authors.initials: JM
authors.lastname: Rao
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000187:drug effects; D002861:Chromobacterium / Q000187:drug effects; D021902:Enterobacter aerogenes / Q000187:drug effects; D029222:Piper nigrum / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts