[Protective effect of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury in rats].
OBJECTIVE
To evaluate protective effects of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury (TBI) in rats.


METHODS
The polysaccharides (RTP) were extracted from Tanguficum Maxim. 120 rats were divided into 15 groups, with 8 rats in each group. RTP at 100, 200 and 400 mg x kg(-1) were administrated orally once a day for five days, and model of brain injury was made by dropping weight method.


RESULTS
RTP reduced water content and malondialdehyde (MDA) levels, and increased total SOD activity and Na+-K+ ATPase activity after injuried.


CONCLUSIONS
The polysaccharides may be one of the effective comptents in Rheum tanguticum, showing significant neuroprotective effects.
Wang
Zhi-peng
ZP
Department of Pharmacology, the Fourth Military Medical University, Xian Shaanxi 710032, China.
Liu
Li
L
Mei
Qi-bing
QB
Zhang
Rong
R
Gu
Jian-wen
JW
Zhang
Xiang
X
Gao
Da-kuan
DK
D000818:Animals; D001930:Brain Injuries / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D002540:Cerebral Cortex / Q000201:enzymology* / Q000648:ultrastructure; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012250:Rheum / Q000737:chemistry; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D018696:Neuroprotective Agents; D011134:Polysaccharides; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000254:Sodium-Potassium-Exchanging ATPase