Expression of Notch in a case of osteosarcoma of the maxilla.
In this immunohistochemical examination, the expression of Notch1 peptide was detected in neoplastic cells in a case of osteosarcoma of the maxilla of a 31-year-old Indonesian male patient. Notch1 peptide appeared in the cytoplasm of neoplastic cells of comparatively well-differentiated areas of the osteosarcoma, an osteoblastic area containing osteoid and/or immature bone tissues. The results suggest that Notch1 is closely related to cytological differentiation or acquisition of cytological characteristics in neoplastic cells of osteosarcoma.
Kawakami
T
T
Hard Tissue Pathology Unit, Department of Hard Tissue Research, Matsumoto Dental University Graduate School of Oral Medicine, 1780 Hirooka-Gobara, Shiojiri 399-0781, Japan. kawakami@po.mdu.ac.jp
Siar
C H
CH
Ng
K H
KH
Shimizu
T
T
Okafuji
N
N
Kurihara
S
S
Hasegawa
H
H
Tsujigiwa
H
H
Nagatsuka
H
H
Nagai
N
N
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008441:Maxillary Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D012516:Osteosarcoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D051881:Receptor, Notch1; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D014408:Biomarkers, Tumor; C497761:NOTCH1 protein, human; D051881:Receptor, Notch1; D011956:Receptors, Cell Surface; D014157:Transcription Factors