title: Behavioral toxicity of acute and subacute exposure to triethyltin in the rat.
abstract: The behavioral effects of both acute and subacute triethyltin (TET) exposure were examined in the rat. Animals acutely exposed to TET at doses of 0, 1.5 and 3.0 mg/kg showed a dose-related decrease in motor activity when tested between 2 and 4 hr following exposure. Subacute (3 week) exposure to TET in the drinking water (5 or 10 ppm) resulted in performance decrements in the following: maze activity, open field behavior, acoustic startle response and landing foot-spread. Early signs of behavioral deficits were observed 2 weeks after 10 ppm TET. These effects were reversible within one month after termination of exposure.
authors.affiliation: Neurotoxicology Division, Health Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
authors.forename: L
authors.initials: L
authors.lastname: Reiter
authors.forename: K
authors.initials: K
authors.lastname: Kidd
authors.forename: G
authors.initials: G
authors.lastname: Heavner
authors.forename: P
authors.initials: P
authors.lastname: Ruppert
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D020258:Neurotoxicity Syndromes / Q000523:psychology*; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects; D014267:Triethyltin Compounds / Q000633:toxicity*
chemical_list: D014267:Triethyltin Compounds; C031575:triethyltin