Immunolocalization of VR1 and VRL1 in rat larynx.
Immunoreactivity for vanilloid receptor subtype 1 (VR1) and its analogue vanilloid receptor-like protein 1 (VRL1) were examined in combination with immunoreactivity for substance P (SP) and calcitonin gene-related peptide (CGRP) in the rat larynx. VR1 and VRL1 immunoreactivity were observed in the intraepithelial free nerve endings, subepithelial nerve plexus and laryngeal epithelial cells. Most of VR1 immunoreactive nerves were also immunoreactive for SP or CGRP. VR1 immunoreactive intraepithelial nerve endings may be laryngeal nociceptors.
Yamamoto
Yoshio
Y
Laboratory of Veterinary Anatomy, Department of Veterinary Sciences, Faculty of Agriculture, Iwate University, Ueda 3-19-8, Morioka, Iwate, 080-8550, Japan. yyoshio@iwate-u.ac.jp
Taniguchi
Kazuyuki
K
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D007150:Immunohistochemistry / Q000379:methods; D007473:Ion Channels / Q000378:metabolism*; D007830:Larynx / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011955:Receptors, Drug / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism; D050916:TRPV Cation Channels
D007473:Ion Channels; D011955:Receptors, Drug; D050916:TRPV Cation Channels; C493922:Trpv1 protein, rat; C476722:Trpv2 protein, rat; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide