title: Estrogen decreases levels of calcineurin in rat amygdala and hippocampus.
abstract: We examined the effects of estradiol benzoate (E2) on the protein expression of calcineurin in amygdaloid and hippocampal structures of ovariectomized (OVX) rats. Significant decreases in levels of calcineurin immunolabeling were seen in the medial and basomedial, but not central or basolateral, amygdala. Estrogen also reduced calcineurin immunoreactivity in the CA1 region of the hippocampus, but not in the CA3 region, hilus or ventral or dorsal dentate gyrus structures of hippocampus. These results indicate that E2 acts on calcineurin in a neuroanatomically specific manner and may be involved in estrogen-mediated regulation of gene expression.
authors.affiliation: Departments of Anatomy, University of Illinois at Chicago, 808 South Wood Street (M/C 512), Chicago, IL 60612, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Pandey
authors.forename: Rochelle S
authors.initials: RS
authors.lastname: Cohen
mesh_terms: D000679:Amygdala / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007150:Immunohistochemistry / Q000379:methods; D010052:Ovariectomy / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C074283:estradiol 3-benzoate; D004958:Estradiol; D019703:Calcineurin