title: [The effect of hyaluronic acid external film on rats wound healing].
abstract: OBJECTIVE
  To observe the effect of an external film of hyaluronic acid (HA) on the rats wound healing.
  
  
  METHODS
  Forty-eight SD rats were randomly separated into eight groups of 6 rats each. Bilateral dorsal cuts were performed on each rat, left wound was used as the experiment with HA external film and right wound was used as the control only with normal saline. The process of healing was observed histologically following 1st, 3rd, 5th, 7th, 9th, 14th, 21st, and 28th days postoperatively.
  
  
  RESULTS
  Inflammation was lighter and epidermal healing was faster in the experimental group than those in the control. The fibroblasts degenerated and the collagen fiber changed to slim and loose bunches in the experimental group.
  
  
  CONCLUSIONS
  The results indicated that HA external film could have powerful infiltrating activity at the early stage of wound healing, it could accelerate the healing of epidermis and delay the formation of keratinization layer.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Gui-yun
authors.initials: GY
authors.lastname: Ren
authors.forename: Fu-sheng
authors.initials: FS
authors.lastname: Dong
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Pei-kai
authors.initials: PK
authors.lastname: Shi
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D004333:Drug Administration Routes; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D006820:Hyaluronic Acid; D003094:Collagen