[Estimation of intake level of bisphenol A in Japanese pregnant women based on measurement of urinary excretion level of the metabolite].
OBJECTIVE
The daily bisphenol A (BPA) intake level of Japanese pregnant women was surveyed based on the measurement of the urinary excretion level of a BPA metabolite.


METHODS
Spot urine samples were collected from 56 pregnant women who visited the gynecology division of a hospital for a routine health check between June and October 2003. The urinary concentrations of the BPA metabolite and creatinine were measured by GC/MS/MS and spectrophotometry, respectively. Daily BPA intake was assumed to be equal to daily excretion.


RESULTS
The daily intake of BPA among Japanese pregnant women was estimated to be in the range of < 0.3 to 7.9 microg/day (median < 2.0 microg/day), being consistent with the levels in previous studies for non-pregnant Japanese women. This level was far below the current Acceptable Daily Intake (0.01 mg/kg/day) which was set by the European Commission. The maximum estimated intake per body weight (0.16 microg/kg/day) reached 1/10 of the Lowest Adverse Effect Level of BPA for pregnant mice for a reproductive effect on the offspring (2 microg/kg/day).


CONCLUSIONS
It is desirable to lessen BPA intake from a precautionary viewpoint, particularly in pregnant women.
Fujimaki
Kayumi
K
Institute of Environmental Studies, University of Tokyo, Tokyo, Japan.
Arakawa
Chikako
C
Yoshinaga
Jun
J
Watanabe
Chiho
C
Serizawa
Shigeko
S
Imai
Hideki
H
Shiraishi
Hiroaki
H
Mizumoto
Yoshifumi
Y
D001559:Benzhydryl Compounds; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007564:Japan; D010636:Phenols / Q000008:administration & dosage* / Q000378:metabolism / Q000652:urine; D011247:Pregnancy / Q000652:urine*; D013053:Spectrophotometry; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds