title: Acute lymphoblastic leukemia with coexpression of CD56 and CD57: case report.
abstract: The authors present the clinical profile of a 6-year-old girl with an unusual immunophenotype of acute lymphoblastic leukemia (ALL). At the initial presentation, massive hepatosplenomegaly developed. The leukemic cells were myeloperoxidase-negative and morphologically lymphoblastic. These cells were positive for B-precursor-cell (CD10, CD19) antigens and natural killer cells (CD56, CD57). Rearrangements of both immunoglobulin heavy chain alleles and monoallelic rearrangement of T-cell receptors (TCRs)-beta and -delta genes, but not that of TCR-gamma gene, were detected, suggesting that these cells being of B-precursor origin. The patient received chemotherapy for extremely high-risk ALL with a good response. To the authors' knowledge, this is the first pediatric case describing coexpression of CD56 and CD57 on B-lineage ALL.
authors.affiliation: Department of Pediatrics, Nishi-Kobe Medical Center, 5-7-1 Kojidai, Nishi-ku, Kobe 651-2273, Japan. kskmatsu@s4.dion.ne.jp
authors.forename: Kousaku
authors.initials: K
authors.lastname: Matsubara
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yura
authors.forename: Takuya
authors.initials: T
authors.lastname: Hirata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nigami
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Harigaya
authors.forename: Hideo
authors.initials: H
authors.lastname: Nozaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukaya
authors.forename: Kunizo
authors.initials: K
authors.lastname: Baba
mesh_terms: D015703:Antigens, CD / Q000097:blood / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology; D019002:CD56 Antigen / Q000097:blood / Q000235:genetics*; D018959:CD57 Antigens / Q000097:blood / Q000235:genetics*; D002648:Child; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000235:genetics* / Q000276:immunology
chemical_list: D015703:Antigens, CD; D019002:CD56 Antigen; D018959:CD57 Antigens