title: Interfering with cancer: a brief outline of advances in RNA interference in oncology.
abstract: RNA interference (RNAi) is a potent and ubiquitous gene-silencing mechanism that is generating considerable excitement in the fields of molecular biology and gene therapy. It is now in widespread use for loss-of-function analysis in many diseases including cancer. Nevertheless, RNAi is still in its infancy, with new discoveries appearing on a monthly basis. This article presents a brief outline of the history and recent advances in RNAi with a specific focus on its potential in oncology.
authors.affiliation: Axis Shield ASA, Ulvenveien 87, NO-0581 Oslo, Norway. phil.rye@no.axis-shield.com
authors.forename: P D
authors.initials: PD
authors.lastname: Rye
authors.forename: T
authors.initials: T
authors.lastname: Stigbrand
mesh_terms: D015316:Genetic Therapy; D006801:Humans; D008495:Medical Oncology / Q000639:trends; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D034622:RNA Interference