Screening of New Caledonian and Vanuatu medicinal plants for antiprotozoal activity.
Sixty-seven extracts of 30 medicinal plants traditionally used in New Caledonia or Vanuatu by healers to treat inflammation, fever and in cicatrizing remedies were evaluated in vitro for their antiprotozoal activity against Leishmania donovani, Leishmania amazonensis and Trypanosoma cruzi. Among the selected plants, Pagiantha cerifera was the most active against both Leishmania species; four extracts were active against promastigotes of Leishmania donovani at EC(50) values inferior to 5 microg/ml. Garcinia pedicillata extract had an EC(50) value of 12.5 microg/ml against intracellular amastigotes of Leishmania amazonensis. Alone Amborella trichopoda reduced by more of 80% the trypomastigotes of Trypanosoma cruzi in the blood.
Billo
M
M
Laboratoire de Pharmacognosie (associé au CNRS-BioCIS), Faculté de Pharmacie, Université Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France.
Fournet
A
A
Cabalion
P
P
Waikedre
J
J
Bories
C
C
Loiseau
P
P
Prina
E
E
de Arias
A Rojas
AR
Yaluff
G
G
Fourneau
C
C
Hocquemiller
R
R
D000818:Animals; D004353:Drug Evaluation, Preclinical; D007893:Leishmania donovani / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D009510:New Caledonia; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects; D009514:Vanuatu
D010936:Plant Extracts; D014344:Trypanocidal Agents