title: Anesthetist to patient transmission of hepatitis C virus associated with non exposure-prone procedures.
abstract: A 44-year-old lady was diagnosed with acute hepatitis C virus (HCV) infection 8 weeks after hysterectomy at which the attending anesthetist was known to be hepatitis C seropositive. Comparative nucleotide sequence analysis and phylogenetic comparison proved that transmission had occurred from the anesthetist to the patient. The patient had received general anesthesia with endotracheal intubation and peripheral intravenous cannulation. No exposure-prone anesthetic procedures had been performed. This is the first case described in UK involving transmission from an anesthetist to a patient during anesthesia where no exposure prone procedures were carried out. It is the first example in which the anesthetist was known to be seropositive for hepatitis C prior to the operation.
authors.affiliation: Barts and Royal London Hospital, Queen Mary College of Medicine and Dentistry, London, United Kingdom. J.E.D.Mawdsley@qmul.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Mawdsley
authors.forename: C G
authors.initials: CG
authors.lastname: Teo
authors.forename: M
authors.initials: M
authors.lastname: Kyi
authors.forename: M
authors.initials: M
authors.lastname: Anderson
mesh_terms: D000328:Adult; D000770:Anesthesia, Endotracheal / Q000009:adverse effects*; D000768:Anesthesia, General / Q000009:adverse effects*; D003428:Cross Infection / Q000635:transmission* / Q000821:virology; D018076:DNA, Complementary / Q000737:chemistry; D004279:DNA, Viral / Q000737:chemistry; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification; D006526:Hepatitis C / Q000635:transmission*; D006801:Humans; D007044:Hysterectomy; D017757:Infectious Disease Transmission, Professional-to-Patient / Q000379:methods*; D017720:Molecular Epidemiology; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D006113:United Kingdom
chemical_list: D018076:DNA, Complementary; D004279:DNA, Viral