title: Fluvastatin and bisoprolol for the reduction of perioperative cardiac mortality and morbidity in high-risk patients undergoing non-cardiac surgery: rationale and design of the DECREASE-IV study.
authors.affiliation: Department of Surgery, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Olaf
authors.initials: O
authors.lastname: Schouten
authors.forename: Don
authors.initials: D
authors.lastname: Poldermans
authors.forename: Loes
authors.initials: L
authors.lastname: Visser
authors.forename: Miklos D
authors.initials: MD
authors.lastname: Kertai
authors.forename: Jan
authors.initials: J
authors.lastname: Klein
authors.forename: Hero
authors.initials: H
authors.lastname: van Urk
authors.forename: Maarten L
authors.initials: ML
authors.lastname: Simoons
authors.forename: Louis L
authors.initials: LL
authors.lastname: van de Ven
authors.forename: Maarten
authors.initials: M
authors.lastname: Vermeulen
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Lameris
authors.forename: Eric
authors.initials: E
authors.lastname: Boersma
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D017298:Bisoprolol / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000401:mortality* / Q000517:prevention & control; D004359:Drug Therapy, Combination; D017558:Elective Surgical Procedures / Q000401:mortality*; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use*; D000077340:Fluvastatin; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D015994:Incidence; D007211:Indoles / Q000627:therapeutic use*; D007431:Intraoperative Complications / Q000401:mortality / Q000517:prevention & control; D009203:Myocardial Infarction / Q000453:epidemiology / Q000517:prevention & control; D019990:Perioperative Care; D011183:Postoperative Complications / Q000401:mortality / Q000517:prevention & control*; D011292:Premedication; D016016:Proportional Hazards Models; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D018570:Risk Assessment
chemical_list: D000319:Adrenergic beta-Antagonists; D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D000077340:Fluvastatin; D017298:Bisoprolol