Simple and efficient synthesis of substituted 2-pyrrolidinones, 2-pyrrolones, and pyrrolidines from enaminones of Baylis-Hillman derivatives of 3-isoxazolecarbaldehydes.
The enaminones, generated from derivatives of appropriately substituted Baylis-Hillman adducts of 3-isoxazolecarbaldehydes, undergo intramolecular ring-closure reactions to afford substituted 2-pyrrolidinones, 1,5-dihydro-2-pyrrolones, and N-substituted pyrrolidines in good yields.
Singh
Vijay
V
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
Saxena
Rashmi
R
Batra
Sanjay
S
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007555:Isoxazoles / Q000737:chemistry*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis*; D011760:Pyrrolidinones / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000447:Aldehydes; D007555:Isoxazoles; D011759:Pyrrolidines; D011760:Pyrrolidinones