Basic principles of drug--excipients interactions.
Excipients are generally considered inert additives included in drug formulation to help in the manufacturing, administration or absorption. Other reasons for inclusion concern product differentiation, appearance enhancement or retention of quality. Excipients can initiate, propagate or participate in chemical or physical interactions with an active substance, possibly leading to compromised quality or performance of the medication. Understanding the chemical and physical nature of excipients, the impurities or residues associated with them and how they may interact with other materials, or with each other, forewarns the pharmaceutical technologist of possibilities for undesirable developments.
Vranić
Edina
E
Department of Pharmaceutical Technology, University of Sarajevo, Faculty of Pharmacy, Cekalusa 10, Bosnia and Herzegovina.
D004340:Drug Contamination; D004347:Drug Interactions; D004355:Drug Stability; D005079:Excipients / Q000009:adverse effects / Q000737:chemistry
D005079:Excipients