title: Autoshaping of chlordiazepoxide drinking in non-deprived rats.
abstract: Effects of autoshaping procedures (Paired versus Random) and sipper fluid [chlordiazepoxide (CDP) versus water] on sipper-directed drinking were evaluated in 32 male Long-Evans rats maintained with free access to food and water. For the Paired/CDP group (n = 16), autoshaping procedures consisted of the presentation of the CDP sipper conditioned stimulus (CS) followed by the response-independent presentation of the food unconditioned stimulus (US). The concentration of CDP in the sipper CS (0.05, 0.10, 0.15, 0.20, and 0.25 mg/ml CDP) was increased across sessions. The Paired/Water group (n = 8) received only water in the sipper CS. The Random/CDP group (n = 8) received the CDP sipper CS and food US randomly with respect to one another. The Paired/CDP group drank significantly more of the 0.20 mg/ml and 0.25 mg/ml CDP solutions than the Random/CDP control, and more fluid than the Paired/Water control group when the sipper CS for the Paired/CDP group contained the three highest concentrations of CDP. CS-Only extinction procedures reliably reduced sipper CS-directed drinking in the Paired/CDP and the Paired/Water groups, but not in the Random/CDP group. Data are consistent with the hypothesis that Pavlovian autoshaping procedures induce sipper CS-directed drinking of CDP in rats deprived of neither food nor fluid. Implications for the autoshaping model of drug abuse are discussed.
authors.affiliation: Department of Psychology and Center of Alcohol Studies, Rutgers University, 607 Allison Road, Piscataway, NJ 08854-8001, USA. tomie@rci.rutgers.edu
authors.forename: Arthur
authors.initials: A
authors.lastname: Tomie
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Wong
authors.forename: Larissa A
authors.initials: LA
authors.lastname: Pohorecky
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology; D002707:Chlordiazepoxide / Q000008:administration & dosage*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D011897:Random Allocation; D051381:Rats; D020318:Rats, Long-Evans; D012054:Reinforcement, Psychology
chemical_list: D006993:Hypnotics and Sedatives; D002707:Chlordiazepoxide