title: [Clinical study on the antithrombotic effects of Holothuria ldeucospilota acidic mucopolysaccharide].
abstract: OBJECTIVE
  To study the antithrombotic effects of Holothuria Ldeucospilota Acidic Mucopolysaccharide (HLAM).
  
  
  METHODS
  A series of variables were observed before and after treatment with HLAM in normal middle-aged subjects and patients recovering from cerebral embolism or suffering from ischemic heart disease, each of which were divided into two groups according to the dosage administered (60 mg/d and 120 mg/d).
  
  
  RESULTS
  The fat metabolism was enhanced in addition to the anticoagulant and the blood viscosity reducing effects. No side-effect was found.
  
  
  CONCLUSIONS
  HLAM is a promising drug for antithrombotic therapy.
authors.affiliation: Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: D
authors.initials: D
authors.lastname: Hu
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Jin
authors.forename: S
authors.initials: S
authors.lastname: Lu
authors.forename: C
authors.initials: C
authors.lastname: Jiang
authors.forename: B
authors.initials: B
authors.lastname: Qu
authors.forename: J
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D016022:Case-Control Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000737:chemistry* / Q000494:pharmacology*; D006025:Glycosaminoglycans / Q000737:chemistry* / Q000494:pharmacology*; D047332:Holothuria / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D020766:Intracranial Embolism / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000378:metabolism
chemical_list: D005343:Fibrinolytic Agents; D006025:Glycosaminoglycans