Large clinical trials in musculoskeletal trauma: are they possible? Lessons learned from the international study of the use of rhBMP-2 in open tibial fractures.
Csimma
Cristina
C
Wyeth Research, 87 Cambridge Park Drive, Office 3013, Cambridge, MA 02140, USA. ccsimma@wyeth.com
Swiontkowski
Marc F
MF
D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D026661:Clinical Trials Data Monitoring Committees; D005597:Fractures, Open / Q000628:therapy*; D006801:Humans; D007391:International Cooperation; D015337:Multicenter Studies as Topic; D009141:Musculoskeletal System / Q000293:injuries*; D017063:Outcome Assessment, Health Care; D018579:Patient Selection; D010865:Pilot Projects; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D013978:Tibial Fractures / Q000628:therapy*; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta