title: The acidity constants of some pyrimidine bases in various water-organic solvent media.
abstract: The acid ionization constants of some pyrimidine bases of nucleic acids were determined pH-metrically at 25 degrees C and at the constant ionic strength I = 0.10 mol l(-1) (KNO3) in pure water as well as in aqueous media containing variable mole percentages (5-30%) of organic solvents. The organic solvents used were methanol, ethanol, N,N-dimethylformamide (DMF), dimethylsulfoxide (DMSO), acetonitrile, acetone and dioxane. The results obtained indicated that the acidity constants are generally decreased as the content of an organic solvent in the medium is increased. It was deduced that the hydrogen bonding interactions and the solvent basicity in addition to the electrostatic effect are the major effects influencing significantly the acid ionization process of pyrimidine bases in the different water-organic solvent media. Some thermodynamic parameters (deltaH, deltaG degrees, deltaS degrees) of the ionization process over the temperature range 5-45 degrees C in pure water were also determined and discussed.
authors.affiliation: Department of Chemistry, Faculty of Science, Minia University, El-Minia, Egypt.
authors.forename: Iman T
authors.initials: IT
authors.lastname: Ahmed
authors.forename: Ekram S
authors.initials: ES
authors.lastname: Soliman
authors.forename: Ahmed A A
authors.initials: AA
authors.lastname: Boraei
mesh_terms: D000096:Acetone / Q000737:chemistry; D000097:Acetonitriles / Q000737:chemistry; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004126:Dimethylformamide / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D000432:Methanol / Q000737:chemistry; D009994:Osmolar Concentration; D011743:Pyrimidines / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D055672:Static Electricity; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*
chemical_list: D000097:Acetonitriles; D004146:Dioxanes; D011743:Pyrimidines; D012997:Solvents; D014867:Water; D000096:Acetone; D000431:Ethanol; D004126:Dimethylformamide; C030986:pyrimidine; D000432:Methanol; D004121:Dimethyl Sulfoxide; C032159:acetonitrile