title: [Effects of Danshen Decoction on experimental gastric ulcer in rats and mice].
abstract: OBJECTIVE
  To investigate the preventive and therapeutic effects of Danshen Decoction on gastric ulcer in experimental animal models.
  
  
  METHODS
  The model of water immersion restraint stress ulcer in mice, and the models of acetic acid impaired gastric ulcer and pyloric ligation gastric ulcer in rats were established. The total gastric acid, the activity of pepsin and the amount of gastric wall binding mucus were detected.
  
  
  RESULTS
  Danshen Decoction reduced the acute gastric mucosal lesion. The effect of 5.0 or 10.0 g/kg group was obviously better than that of the normal saline control group (P<0.05 and P<0.01 respectively). Danshen Decoction accelerated the healing of ulcer induced by acetic acid significantly, and increased the content of gastric wall binding mucus (P<0.01); and it also inhibited the formation of gastric ulcer induced by pyloric ligation, while having no influence on the secretion of gastric acid and the activity of pepsin.
  
  
  CONCLUSIONS
  Danshen Decoction has a significant anti-ulcerative effect, which may be related to improving the gastric mucosal defensive function.
authors.affiliation: Medical and Pharmaceutical Institute, Yangzhou University, Yangzhou, Jiangsu Province 225001, China. lily970907@sina.com
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal