title: Regression of pancreatic fibrosis after steroid therapy in patients with autoimmune chronic pancreatitis.
abstract: Autoimmune chronic pancreatitis (AICP) is a clinically attractive entity because of its dramatic response to steroid therapy. Reported cases of AICP until now have focused on mainly clinical, radiologic, and laboratory features with steroid therapy. There are, however, few reports that demonstrate histologic recovery, especially regression of pancreatic fibrosis in patients with AICP. Fibrosis in chronic pancreatitis is generally believed to be irreversible. Our observation of reversibility of pancreatic fibrosis is, therefore, noteworthy. We illustrate this with 2 cases of AICP in which pancreatic fibrosis as well as inflammatory infiltration regressed after a short course of oral steroid therapy.
authors.affiliation: Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Moon Hee
authors.initials: MH
authors.lastname: Song
authors.forename: Myung-Hwan
authors.initials: MH
authors.lastname: Kim
authors.forename: Sung Koo
authors.initials: SK
authors.lastname: Lee
authors.forename: Dong Wan
authors.initials: DW
authors.lastname: Seo
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Lee
authors.forename: Jimin
authors.initials: J
authors.lastname: Han
authors.forename: Kyu-Pyo
authors.initials: KP
authors.lastname: Kim
authors.forename: Young Il
authors.initials: YI
authors.lastname: Min
authors.forename: Dong Eun
authors.initials: DE
authors.lastname: Song
authors.forename: Ensil
authors.initials: E
authors.lastname: Yu
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Jang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000473:pathology*; D005355:Fibrosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D050500:Pancreatitis, Chronic / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology*; D011239:Prednisolone / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone