Brain stem glioblastoma with multiple large cyst formation and leptomeningeal dissemination in a 4-year-old girl.
The authors report a 4-year-old girl who developed brain stem glioblastoma. Meningeal irritation was present at onset. Magnetic resonance imaging revealed intracranial and intraspinal leptomeningeal dissemination, which progressed faster than the original tumor. Multiple large cysts developed at the interhemispheric and prepontine cisterns, resulting in progressive obstructive hydrocephalus. The patient survived only 5 months after presentation. Histology was verified by autopsy.
Kanai
Rie
R
Department of Pediatrics, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan. rkana1@med.shimane-u.ac.jp
Tasaka
Masaru
M
Sejima
Hitoshi
H
Uchida
Nobue
N
Nakano
Akinobu
A
Akiyama
Yasuhiko
Y
Yamasaki
Toshiki
T
Yamaguchi
Seiji
S
D001099:Arachnoid / Q000473:pathology; D016080:Arachnoid Cysts / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology; D020295:Brain Stem Neoplasms / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D005909:Glioblastoma / Q000150:complications* / Q000503:physiopathology / Q000556:secondary*; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000556:secondary*; D010841:Pia Mater / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology; D013346:Subarachnoid Space / Q000473:pathology / Q000503:physiopathology