Conceptualizing "suicidal genetically engineered microorganisms" for bioremediation applications.
Use of genetically modified microorganisms (GEMs) for pollution abatement has been limited because of risks associated with their release in the environment. Recent developments in the area of recombinant DNA technologies have paved the way for conceptualizing "suicidal genetically engineered microorganisms" (S-GEMS) to minimize such anticipated hazards and to achieve efficient and safer bioremediation of contaminated sites. Our strategy of designing a novel S-GEM is based on the knowledge of killer-anti-killer gene(s) that would be susceptible to programmed cell death after detoxification of any given contaminated site(s).
Pandey
Gunjan
G
Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India.
Paul
Debarati
D
Jain
Rakesh K
RK
D001419:Bacteria / Q000235:genetics*; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors / Q000235:genetics; D001673:Biodegradation, Environmental; D004274:DNA, Recombinant / Q000032:analysis; D004784:Environmental Monitoring; D018014:Gene Transfer Techniques; D005818:Genetic Engineering; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D008828:Microbiological Techniques; D010957:Plasmids / Q000235:genetics; D018570:Risk Assessment
D001427:Bacterial Toxins; D004274:DNA, Recombinant