title: High-resolution reference ranges for estradiol, luteinizing hormone, and follicle-stimulating hormone in men and women using the AxSYM assay system.
abstract: OBJECTIVE
  High-resolution reference ranges are essential for reproductive hormones due to the significant day-to-day variation seen with these analytes.
  
  
  METHODS
  The performance of AxSYM assays for estradiol, luteinizing hormone (LH), and follicle-stimulating hormone was evaluated.
  
  
  RESULTS
  These studies validate the performance of each assay, permitting high-resolution reference ranges to be established.
  
  
  CONCLUSIONS
  The high-resolution reference range data provided herein for both normally cycling females and males should be applicable to a wide variety of clinical situations.
authors.affiliation: Clinical Chemistry Laboratory, Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. asdighe@partners.or
authors.forename: Anand S
authors.initials: AS
authors.lastname: Dighe
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Moy
authors.forename: Frances J
authors.initials: FJ
authors.lastname: Hayes
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Sluss
mesh_terms: D000293:Adolescent; D000328:Adult; D004958:Estradiol / Q000097:blood / Q000592:standards*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000592:standards*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000592:standards*; D008297:Male; D008598:Menstruation; D008722:Methods; D008875:Middle Aged; D012016:Reference Values
chemical_list: D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone