title: Ionic liquids as advantageous solvents for headspace gas chromatography of compounds with low vapor pressure.
abstract: The potential of ionic liquids as solvents for headspace gas chromatography was investigated. Three compounds with boiling points above 200 degrees C were selected to demonstrate the feasibility of the concept described. 2-Ethylhexanoic acid, formamide, and tri-n-butylamine as examples of acidic, neutral, and basic analytes were dissolved in acidic 1-n-butyl-3-methylimidazolium hydrogen sulfate (1), neutral 1-n-butyl-2,3-dimethylimidazolium dicyanamide (2), and 2 containing 1,8-diazabicyclo[5.4.0]undec-7-ene to adjust basic conditions. All analytes could be determined with limits of detection and limits of quantification in the low-ppm concentration range.
authors.affiliation: Sandoz GmbH, Biochemiestrasse 10, 6250 Kundl, Austria, Immodal Pharmaka GmbH, Bundesstrasse 44, 6111 Volders, Austria. max.andre@gx.novartis.com
authors.forename: M
authors.initials: M
authors.lastname: Andre
authors.forename: J
authors.initials: J
authors.lastname: Loidl
authors.forename: G
authors.initials: G
authors.lastname: Laus
authors.forename: H
authors.initials: H
authors.lastname: Schottenberger
authors.forename: G
authors.initials: G
authors.lastname: Bentivoglio
authors.forename: K
authors.initials: K
authors.lastname: Wurst
authors.forename: K-H
authors.initials: KH
authors.lastname: Ongania
mesh_terms: D000667:Ampicillin / Q000302:isolation & purification; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D002082:Butylamines / Q000737:chemistry; D002208:Caproates / Q000737:chemistry; D002849:Chromatography, Gas / Q000379:methods*; D019818:Clavulanic Acid / Q000302:isolation & purification; D005559:Formamides / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D007477:Ions; D010401:Penicillin G Benzathine / Q000302:isolation & purification; D011312:Pressure; D012997:Solvents / Q000737:chemistry*
chemical_list: C516563:1-n-butyl-2,3-dimethylimidazolium dicyanamide; C516562:1-n-butyl-3-methylimidazolium hydrogen sulfate; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002082:Butylamines; D002208:Caproates; D005559:Formamides; D007093:Imidazoles; D007477:Ions; D012997:Solvents; C040668:2-ethylhexanoic acid; D019818:Clavulanic Acid; C031066:formamide; D000667:Ampicillin; C036355:tributylamine; C031033:1,8-diazabicyclo(5.4.0)undec-7-ene; D010401:Penicillin G Benzathine