Mechanism of glycogenosome formation in axons of cadmium-induced neuropathy--ultrastructural and biochemical studies.
Numerous glycogenosomes were found in the axoplasm of the sciatic nerves in neuropathy induced by the long-term administration of cadmium to rats. The glycogen particles in the glycogenosomes were larger than those deposited in the intracytoplasmic matrix. Two forms of alpha-glucosidases, acid and neutral, were found in the sciatic nerve of normal rat. Cadmium ions inhibited the activity of the neutral alpha-glucosidase by a maximum of 24.0%, while acid alpha-glucosidase was not inhibited. Hg ions completely inhibited both forms of alpha-glucosidases; however, it has been reported that no glycogenosomes appear in Hg++-induced neuropathy. It was considered that the inhibitory effect of cadmium on the neutral alpha-glucosidase led to the enlargement of glycogen particles, and the large glycogen molecules were then engulfed in the lysosome system.
Hamada
T
T
Department of Pathology, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto City, Japan.
Iwamasa
T
T
Tsuru
T
T
Sato
K
K
Takeuchi
T
T
D000818:Animals; D001369:Axons / Q000378:metabolism / Q000473:pathology*; D002104:Cadmium / Q000633:toxicity*; D006003:Glycogen / Q000378:metabolism*; D008297:Male; D008628:Mercury / Q000633:toxicity; D010523:Peripheral Nervous System Diseases / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000378:metabolism / Q000473:pathology
D002104:Cadmium; D006003:Glycogen; D008628:Mercury