WNT signalling and haematopoiesis: a WNT-WNT situation.
The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.
Staal
Frank J T
FJ
Department of Immunology, Room Ee 838, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands. f.staal@erasmusmc.nl
Clevers
Hans C
HC
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D007938:Leukemia / Q000378:metabolism; D051379:Mice; D015398:Signal Transduction / Q000502:physiology*; D013950:Thymus Gland / Q000502:physiology; D051153:Wnt Proteins
D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins