Ambulatory blood pressure monitoring and active renin in menopausal women treated with amlodipine and hormone replacement therapy.
The aim of this study was to follow up the effect of an 8-week treatment with amlodipine given alone or in combination with hormone replacement therapy (HRT) on blood pressure and active renin in postmenopausal women with mild to moderate arterial hypertension using both conventional clinical blood pressure measurements and ambulatory blood pressure monitoring. Twenty-nine hypertensive menopausal women were divided randomly into two groups according to the treatment regimens: amlodipine and amlodipine plus HRT. The combination with HRT led to normalization of 24-h and daytime systolic and diastolic blood pressure. In contrast to the group treated with amlodipine alone, where a significant fall only of systolic night-time blood pressure was observed, in the group treated with amlodipine plus HRT both systolic and diastolic night-time blood pressure decreased significantly. Active renin did not change significantly after treatment in both groups. Triglycerides decreased significantly and high-density lipoprotein-cholesterol increased significantly only after amlodipine treatment. There were no significant differences in serum total cholesterol and low-density lipoprotein-cholesterol after HRT plus amlodipine. In conclusion, amlodipine is effective in reducing blood pressure in postmenopausal women. The maintenance of a normal circadian blood pressure pattern was influenced by HRT.
Zacharieva
S
S
Clinical Centre of Endocrinology and Gerontology, Medical University, Sofia, Bulgaria.
Shigarminova
R
R
Nachev
E
E
Orbetzova
M
M
Genov
N
N
Kamenov
Z
Z
Atanassova
I
I
Stoynev
A
A
Doncheva
N
N
Borissova
A M
AM
Zingilev
D
D
D017311:Amlodipine / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D008076:Cholesterol, HDL / Q000097:blood; D015914:Estrogen Replacement Therapy; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008593:Menopause; D008875:Middle Aged; D012083:Renin / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D000959:Antihypertensive Agents; D008076:Cholesterol, HDL; D014280:Triglycerides; D017311:Amlodipine; D012083:Renin