Sorting nexins--unifying trends and new perspectives.
The sorting nexins (SNXs) are a family of PX domain-containing proteins found in yeast and mammalian cells that have been proposed to regulate intracellular trafficking. Mammalian SNXs have been suggested to function variously in pro-degradative sorting, internalization, endosomal recycling, or simply in endosomal sorting. In yeast, the defining function for these proteins is a regulation of cargo retrieval. Here we examine recent data on the SNX family of proteins and attempt to draw out unifying themes between the work performed in yeast and mammalian systems.
Carlton
Jez
J
Department of Biochemistry, School of Medical Sciences, University Walk, Clifton, Bristol, BS8 1TD, UK.
Bujny
Miriam
M
Rutherford
Anna
A
Cullen
Pete
P
D000595:Amino Acid Sequence; D000818:Animals; D011992:Endosomes / Q000378:metabolism*; D005544:Forecasting; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D008969:Molecular Sequence Data; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D017386:Sequence Homology, Amino Acid; D033921:Vesicular Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D008565:Membrane Proteins; D033921:Vesicular Transport Proteins