Chlamydia trachomatis and male fertility.
There is increasing evidence that the function of human spermatozoa can be significantly affected by direct exposure to the bacterium Chlamydia trachomatis. This may contribute to sub-fertility in infected individuals by a route that is independent of any damage to the reproductive epithelium. In addition, if a C. trachomatis infection is undiagnosed it could contribute to poor outcomes in assisted conception techniques such as in vitro fertilization. The antibiotics routinely used in IVF culture systems are largely ineffective against chlamydia, emphasizing the importance of screening patients prior to treatment. Moreover, given the many thousands of semen samples provided for analysis by men in primary care (many of which will never undergo assisted conception treatment), it is suggested that this may represent a wasted opportunity to provide screening (and treatment) for the infection using an appropriate test specimen and without the need for additional hospital visits.
Pacey
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Academic Unit of Reproductive and Developmental Medicine, Royal Hallamshire Hospital, Sheffield, UK. A.Pacey@sheffield.ac.uk
Eley
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D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002690:Chlamydia Infections / Q000150:complications* / Q000503:physiopathology; D002692:Chlamydia trachomatis / Q000187:drug effects / Q000502:physiology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007248:Infertility, Male / Q000382:microbiology*; D008297:Male; D027724:Reproductive Techniques, Assisted; D012661:Semen / Q000502:physiology; D013094:Spermatozoa / Q000502:physiology
D000900:Anti-Bacterial Agents