title: Comparison of quantitative angiographic parameters with the magnitude of neointimal hyperplasia measured by volumetric intravascular ultrasound in patients treated with bare metal and nonpolymeric paclitaxel-coated stents.
abstract: We used data from the ASian Paclitaxel-Eluting Stent Clinical Trial (a 3-center, randomized, placebo-controlled trial of nonpolymeric paclitaxel-coated stents with a single-center intravascular ultrasound substudy) to compare angiographic indexes of drug-eluting stent efficacy with the magnitude of intimal hyperplasia (IH) assessed by intravascular ultrasound. Overall, percent IH (IH volume divided by stent volume) was larger in restenotic lesions than in nonrestenotic lesions (46 +/- 19% vs 15 +/- 13%, p <0.0001); angiographic late loss and follow-up diameter stenoses correlated strongly with percent IH.
authors.affiliation: Department of Medicine, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.forename: Myeong-Ki
authors.initials: MK
authors.lastname: Hong
authors.forename: Albert E
authors.initials: AE
authors.lastname: Raizner
authors.forename: Cheol Whan
authors.initials: CW
authors.lastname: Lee
authors.forename: Jae-Joong
authors.initials: JJ
authors.lastname: Kim
authors.forename: Esteban
authors.initials: E
authors.lastname: Escolar
authors.forename: Neal E
authors.initials: NE
authors.lastname: Fearnot
authors.forename: Seong-Wook
authors.initials: SW
authors.lastname: Park
authors.forename: Seung-Jung
authors.initials: SJ
authors.lastname: Park
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Weissman
mesh_terms: D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging* / Q000517:prevention & control; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology*; D016503:Drug Delivery Systems; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging; D017239:Paclitaxel / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D015607:Stents; D017539:Tunica Intima / Q000000981:diagnostic imaging* / Q000473:pathology*; D018084:Ultrasonography, Interventional
chemical_list: D017239:Paclitaxel