title: AMPA receptor antagonists as potential anticonvulsant drugs.
abstract: Over the last years alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPARs) have been intensively studied owing to their crucial role in physiological and pathological processes. Efforts targeting AMPAR have been focused on identification of ligands as potential therapeutic agents useful in the prevention and treatment of a variety of neurological and non-neurological diseases. In particular, extensive work was addressed to the discovery of selective antagonists some of which proved to be potent anticonvulsant agents.
authors.affiliation: Department of Experimental and Clinical Medicine, University of Catanzaro, Italy.
authors.forename: Giovambattista
authors.initials: G
authors.lastname: De Sarro
authors.forename: Rosaria
authors.initials: R
authors.lastname: Gitto
authors.forename: Emilio
authors.initials: E
authors.lastname: Russo
authors.forename: Guido Ferreri
authors.initials: GF
authors.lastname: Ibbadu
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Barreca
authors.forename: Laura
authors.initials: L
authors.lastname: De Luca
authors.forename: Alba
authors.initials: A
authors.lastname: Chimirri
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D001667:Binding, Competitive / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*
chemical_list: D000927:Anticonvulsants; D018091:Receptors, AMPA