Expression of interleukin-8 receptor A predicts poor outcome in patients with nasopharyngeal carcinoma.
OBJECTIVE
The authors recently demonstrated that interleukin-8 (IL-8) is induced by Epstein-Barr virus encoding latent membrane protein 1 and that IL-8 is overexpressed in tumor cells and correlates significantly with angiogenesis in nasopharyngeal carcinoma. The present objective was to investigate the expressions and the roles of IL-8 receptors in nasopharyngeal carcinoma.


METHODS
Retrospective patient file review and immunohistochemical study of tissues of patients with nasopharyngeal carcinoma.


METHODS
The authors examined the expressions of two high-affinity IL-8 receptors, IL-8 receptor A (IL8RA) and IL-8 receptor B (IL8RB), in 30 patients with nasopharyngeal carcinoma by immunohistochemical analysis.


RESULTS
As expected, both IL-8 receptors were expressed on microvessels in tumor nests and surrounding stroma. Interestingly, they were also abundantly expressed on tumor cells. The expressions of IL8RA and IL8RB had no associations with gender, metastasis, or clinical stage. However, the expression of IL8RA in tumors significantly correlated with a shorter overall survival rate (P = .0045). Although the estimated 5-year overall survival rate for IL8RA-negative patients was 68.2%, that in IL8RA-positive patients was only 33.3%.


CONCLUSIONS
The study results suggest that the expression of IL8RA in tumor cells becomes an important indicator of poor prognosis in nasopharyngeal carcinoma.
Horikawa
Toshiyuki
T
Department of Otolaryngology, Fukui Saiseikai Hospital, Fukui, Japan. hrkw3@yahoo.co.jp
Kaizaki
Yasuharu
Y
Kato
Hideaki
H
Furukawa
Mitsuru
M
Yoshizaki
Tomokazu
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000098:blood supply / Q000378:metabolism* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000401:mortality; D009389:Neovascularization, Pathologic; D011379:Prognosis; D023062:Receptors, Interleukin-8A / Q000378:metabolism*; D023063:Receptors, Interleukin-8B / Q000378:metabolism; D015996:Survival Rate
D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B