title: A comparative analysis of immunorestoration and recovery with conventional and immunotherapeutic protocols in canine generalized demodicosis: a newer insight of immunotherapeutic efficacy of T11TS.
abstract: Demodex canis is a natural inhabiting mite of canine skin. Immunological disorder or genetic disorder induces the Demodex population to proliferate vigorously resulting in generalized demodicosis with consequent chronic immunosuppression. Signs of generalized demodicosis include alopecia, crysting, erythema, secondary pyoderma etc. Amitraz, an acaricide, is used conventionally for the treatment of generalized demodicosis. In many instances, the disease relapses due to the residual immunosuppression. The need of an immunorestorative therapy has been urged in generalized demodicosis. Two immunorestorative drugs, namely, Immuplus, a herbal drug, and T11TS, a sheep erythrocyte surface glycoprotein, has been used in two separate groups of dogs having generalized demodicosis and receiving Amitraz treatment. It was observed that though Amitraz treated group responded to the therapy showing increased E-rosettes and nonspecific cytotoxic efficacy of T-lymphocytes and decrease in phagocytic potential of macrophages, the groups treated with the immunotherapeutics like Immuplus and T11TS, responded better. However, the group treated with T11TS showed best recovery. These results emphasize the need for an immunorestorative therapy in generalized demodicosis and provide data in favor of T11TS as a better immunomodulator in comparison to Immuplus.
authors.affiliation: Cellular and Molecular Immunology Laboratory, Department of Physiology, Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences, Institute of Post Graduate Medical Education and Research, 244B, A.J.C. Bose Road, Kolkata 700020, India.
authors.forename: P
authors.initials: P
authors.lastname: Sarkar
authors.forename: J
authors.initials: J
authors.lastname: Mukherjee
authors.forename: A
authors.initials: A
authors.lastname: Ghosh
authors.forename: M
authors.initials: M
authors.lastname: Bhattacharjee
authors.forename: S
authors.initials: S
authors.lastname: Mahato
authors.forename: A
authors.initials: A
authors.lastname: Chakraborty
authors.forename: M
authors.initials: M
authors.lastname: Mondal
authors.forename: C
authors.initials: C
authors.lastname: Banerjee
authors.forename: Swapna
authors.initials: S
authors.lastname: Chaudhuri
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic; D004283:Dog Diseases / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D004285:Dogs; D007167:Immunotherapy; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins / Q000494:pharmacology / Q000627:therapeutic use*; D010587:Phagocytosis / Q000276:immunology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D012397:Rosette Formation; D012871:Skin Diseases / Q000276:immunology* / Q000473:pathology / Q000628:therapy* / Q000662:veterinary
chemical_list: D008562:Membrane Glycoproteins; D010936:Plant Extracts