title: An active ingredient of Cat's Claw water extracts identification and efficacy of quinic acid.
abstract: Historic medicinal practice has defined Cat's Claw, also known as Una de Gato or Uncaria tomentosa, as an effective treatment for several health disorders including chronic inflammation, gastrointestinal dysfunction such as ulcers, tumors and infections. The efficacy of Cat's Claw was originally believed, as early as the 1960s, to be due to the presence of oxindole alkaloids. However, more recently water-soluble Cat's Claw extracts were shown not to contain significant amounts of alkaloids (<0.05%), and yet still were shown to be very efficacious. Here we characterize the active ingredients of a water-soluble Cat's Claw extract called C-Med-100 as inhibiting cell growth without cell death thus providing enhanced opportunities for DNA repair, and the consequences thereof, such as immune stimulation, anti-inflammation and cancer prevention. The active ingredients were chemically defined as quinic acid esters and could also be shown to be bioactive in vivo as quinic acid.
authors.affiliation: Section for Immunology, Department of Clinical Medicine (Neuroscience), Lund University, BMC I:13, SE-221 84 Lund, Sweden.
authors.forename: Yezhou
authors.initials: Y
authors.lastname: Sheng
authors.forename: Christina
authors.initials: C
authors.lastname: Akesson
authors.forename: Kristin
authors.initials: K
authors.lastname: Holmgren
authors.forename: Carl
authors.initials: C
authors.lastname: Bryngelsson
authors.forename: Vincent
authors.initials: V
authors.lastname: Giamapa
authors.forename: Ronald W
authors.initials: RW
authors.lastname: Pero
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic; D001835:Body Weight / Q000187:drug effects; D020948:Cat's Claw; D049109:Cell Proliferation / Q000187:drug effects; D004317:Doxorubicin; D005260:Female; D018922:HL-60 Cells; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects; D007970:Leukopenia / Q000139:chemically induced / Q000188:drug therapy; D009929:Organ Size / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D032070:Uncaria; D014867:Water
chemical_list: D000903:Antibiotics, Antineoplastic; C406667:C-MED-100; D010936:Plant Extracts; D011801:Quinic Acid; D014867:Water; D004317:Doxorubicin