Persistence of Kaposi sarcoma-associated herpesvirus (KSHV)-infected cells in KSHV/HIV-1-coinfected subjects without KSHV-associated diseases.
Inguinal lymph nodes from 24 human immunodeficiency virus (HIV) type 1-infected subjects without Kaposi sarcoma-associated herpesvirus (KSHV)-associated diseases were examined for KSHV infection. KSHV-infected cells were detected at a very low frequency in the lymph nodes of 7 subjects (median frequency, 2 infected cells/10(7) lymph node cells). Latent, but not lytic, KSHV gene expression was detected and KSHV-infected cells were located in B cell-rich areas of lymph node follicles. These findings provide evidence that, in the absence of KSHV-associated diseases, latent infection of lymph node cells provides a mechanism for the persistence of KSHV in KSHV/HIV-1-coinfected persons.
Campbell
Thomas B
TB
Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. thomas.campbell@uchsc.edu.
Staskus
Katherine A
KA
Folkvord
Joy
J
White
Irene E
IE
Neid
James
J
Zhang
Xing-Quan
XQ
Connick
Elizabeth
E
D000328:Adult; D001402:B-Lymphocytes / Q000821:virology*; D004197:Disease Reservoirs; D005260:Female; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1 / Q000502:physiology; D019288:Herpesvirus 8, Human / Q000502:physiology*; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000821:virology; D017735:Virus Latency