title: Unexpected effects of inhaled fluticasone in an HIV patient with asthma.
abstract: International guidelines recommend prescription of inhaled corticosteroids to improve asthma control. Chronic secondary adrenal suppression due to inhaled corticosteroids has been described. We report a case of acute adrenal suppression due to drug interaction between Fluticasone and antiretroviral therapy in a HIV patient. Seeing an increased prevalence of hyperresponsiveness among HIV-infected men, we conclude that coprescription of Fluticasone and highly active antiretroviral therapy must be carefully controlled.
authors.affiliation: Service des Maladies Respiratoires, Hôpital Haut Lévèque, Pessac Cedex, France. cejnaini@9online.fr
authors.forename: C
authors.initials: C
authors.lastname: Nocent
authors.forename: C
authors.initials: C
authors.lastname: Raherison
authors.forename: M
authors.initials: M
authors.lastname: Dupon
authors.forename: A
authors.initials: A
authors.lastname: Taytard
mesh_terms: D000208:Acute Disease; D000280:Administration, Inhalation; D000309:Adrenal Insufficiency / Q000139:chemically induced*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000730:Androstadienes / Q000009:adverse effects* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D000068298:Fluticasone; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D000324:Adrenocorticotropic Hormone; D000068298:Fluticasone; D006854:Hydrocortisone