[Sialoadenitis following ablative therapy with high doses of radioiodine for treatment of differentiated thyroid cancer].
We analyzed eight-three patients who received 3.7 GBq (100 mCi) or 7.4 GBq (200 mCi) after total thyroidectomy for thyroid cancer. This study consisted in clinical and lab analysis (amylase serum level), followed by iodine whole body scan. The sialoadenitis was defined by hyperamylasemia (> 200 U/L). Eleven (13.25%) patients referred spontaneous local pain or after mastication post I 131 ablative therapy. Hyperamylasemia was detected in 31 (37.3%) patients in the second day after treatment. After seven days, serum amylase levels were in normal values in all patients. The symptomatic sialoadenitis was detected more frequently in patients with residual cervical uptake who received I-131 7.4 GBq (70%). The uptake in topography of salivary glands was present in 93.5% of sialoadenitis cases (p < 0.05). Significant statistical correlation was detected between absent of distance metastases and higher incidence of sialoadenitis (p < 0.05). No correlation was demonstrated between this complication and cervical remnants or I-131 dose administered. The sialoadenitis post high dose ablative therapy is a relative common complication with low clinical repercussion. The absent of distance metastases is directly correlated to this complication.
Rosário
Pedro W S
PW
Departamento de Tireóide, Clínica de Endocrinologia e Metabologia, Serviço de Medicina Nuclear, Santa Casa de Belo Horizonte, MG. cepcem.bhz@zaz.com.br
Maia
Frederico F R
FF
Barroso
Alvaro
A
Padrão
Eduardo L
EL
Rezende
Leonardo
L
Purisch
Saulo
S
D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D011832:Radiation Injuries / Q000209:etiology*; D011879:Radiotherapy Dosage; D012793:Sialadenitis / Q000453:epidemiology / Q000209:etiology*; D013964:Thyroid Neoplasms / Q000532:radiotherapy*; D013965:Thyroidectomy
D007457:Iodine Radioisotopes