title: Clinical description and mode of inheritance of idiopathic epilepsy in English springer spaniels.
abstract: OBJECTIVE
  To determine clinical characteristics and mode of inheritance of idiopathic epilepsy (IE) in English Springer Spaniels.
  
  
  METHODS
  Original study.
  
  
  METHODS
  45 dogs with IE and 74 siblings and their respective parents.
  
  
  METHODS
  IE was diagnosed on the basis of age at the time of seizure onset and results of laboratory testing and neurologic examinations. Simple segregation analysis was performed with the Davie method.
  
  
  RESULTS
  Median age at the onset of seizures was 3 years; however, 9 (20%) dogs were between 5 and 6 years old at the time of the onset of seizures. Twenty-one dogs (47%) had generalized seizures, and 24 (53%) had focal onset seizures. Results of segregation analysis were consistent with partially penetrant autosomal recessive or polygenic inheritance. Simulated linkage indicated that there was a 58% chance of obtaining suggestive linkage with the available pedigrees.
  
  
  CONCLUSIONS
  Results of the present study suggest that in English Springer Spaniels, IE segregates in a manner that is consistent with partially penetrant autosomal recessive inheritance (ie, a single major locus with modifying genes) or polygenic inheritance. Given enough families with accurate phenotypic information and available DNA, it should be possible to use genetic linkage analysis to identify chromosomal segments containing the causative gene or genes.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA.
authors.forename: Edward E
authors.initials: EE
authors.lastname: Patterson
authors.forename: P Jane
authors.initials: PJ
authors.lastname: Armstrong
authors.forename: Dennis P
authors.initials: DP
authors.lastname: O'Brien
authors.forename: Monica C
authors.initials: MC
authors.lastname: Roberts
authors.forename: Gary S
authors.initials: GS
authors.lastname: Johnson
authors.forename: James R
authors.initials: JR
authors.lastname: Mickelson
mesh_terms: D000367:Age Factors; D000818:Animals; D001947:Breeding; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D004827:Epilepsy / Q000235:genetics / Q000662:veterinary*; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D008297:Male; D010375:Pedigree; D012640:Seizures / Q000235:genetics / Q000662:veterinary