[Effect of cerium nitrate supplementation to silver sulfathiazole preparations on survival of planctonic and attached to the dermis Staphylococcus aureus cells].
The purpose of this study was to evaluate the influence of preparations containing silver sulfathiazole, with or without cerium nitrate, on survival of Staphylococcus aureus. In the first step, sensitivity of the planctonic bacteria to the tested compounds was determined. Addition of cerium nitrate enhanced the antibacterial activity of silver sulfathiazole by 4 times, as evidenced by MIC and MBC values. For the estimation of antibacterial activity of the mentioned chemotherapeutic on attached bacteria in vitro model of an "infected wound" was applied. Sensitivity of bacteria attached to the dermis was lower than sensitivity of planctonic bacteria. Kinetics of the release of chemotherapeutic compounds incorporated into a collagen dressing was the most effective for the combination of silver sulfathiazole with cerium nitrate.
Lewandowski
Rafał
R
Zakładu Mikrobiologii i Epidemiologii Wojskowego Instytutu Higieny i Epidemiologii w Warszawie.
Grzybowski
Jacek
J
Głowińska
Ewa
E
Stozkowska
Wiesława
W
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001684:Biological Dressings; D002056:Burns / Q000382:microbiology; D002563:Cerium / Q000494:pharmacology*; D003094:Collagen / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects*; D013432:Sulfathiazoles / Q000494:pharmacology*; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control; D013997:Time Factors; D000096926:Benzenesulfonamides
D000891:Anti-Infective Agents, Local; D002563:Cerium; D003094:Collagen; D004338:Drug Combinations; D013432:Sulfathiazoles; C032786:cerium nitrate; C017946:silver sulfathiazole; D000096926:Benzenesulfonamides