title: Poly(ethylene oxide sulfide): new poly(ethylene glycol) derivatives degradable in reductive conditions.
abstract: Poly(ethylene oxide sulfide) (PEOS), polymers consisting of an internal ethylene oxide oligomer and disulfide linkage, were synthesized and characterized. The degree of polymerization was dependent upon temperature, dimethyl sulfoxide condition, and monomer hydrophobicity. The stability of PEOS was measured by the size exclusion chromatography method after the incubation both with and without 5 mM glutathione. The disulfide bond was stable in the extracellular condition but completely degraded in 2 h in the reductive cytosolic condition. Hydrophilic PEOS polymers showed no cytotoxicity on the HepG2 cell line. On the basis of these properties, PEOS can be applied in many drug delivery fields.
authors.affiliation: School of Chemistry & Molecular Engineering, Seoul National University, San 56-1, Shillim-dong, Gwanak-gu, Seoul 151-742, Korea.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lee
authors.forename: Heebeom
authors.initials: H
authors.lastname: Koo
authors.forename: Geun-woo
authors.initials: GW
authors.lastname: Jin
authors.forename: Heejung
authors.initials: H
authors.lastname: Mo
authors.forename: Min Yi
authors.initials: MY
authors.lastname: Cho
authors.forename: Jong-Yeun
authors.initials: JY
authors.lastname: Park
authors.forename: Joon Sig
authors.initials: JS
authors.lastname: Choi
authors.forename: Jong Sang
authors.initials: JS
authors.lastname: Park
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D008970:Molecular Weight; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013696:Temperature; D013997:Time Factors
chemical_list: D013440:Sulfides; D011092:Polyethylene Glycols; D005978:Glutathione; D004121:Dimethyl Sulfoxide