title: [Activation of Langat virus infection in mice under the influence of Licopid].
abstract: The impact of Licopid and purified staphylococcal toxoid on the development of neurovirus infection caused by Langat virus was experimentally studied with mice as a model. The prophylactic (prior to infection) use of licopid was found to activate the infection. In the population of macrophages of different localization the proportion of cells with virus penetration and proliferation increased 5- to 11-fold under the influence of Licopid. The results obtain give evidence to conclude that immunomodulators should be used with caution as they show not only positive effects.
authors.forename: V V
authors.initials: VV
authors.lastname: Vargin
authors.forename: I B
authors.initials: IB
authors.lastname: Semenova
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002448:Cell Adhesion; D004195:Disease Models, Animal; D004669:Encephalitis Viruses, Tick-Borne / Q000502:physiology; D004675:Encephalitis, Tick-Borne / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D008264:Macrophages / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D000276:Adjuvants, Immunologic; D000119:Acetylmuramyl-Alanyl-Isoglutamine