title: Staged initial percutaneous coronary intervention followed by valve surgery ("hybrid approach") for patients with complex coronary and valve disease.
abstract: OBJECTIVE
  The goal of this study was to determine if a "hybrid" approach to the treatment of complex combined coronary and valve disease is superior to the results predicted by a Society of Thoracic Surgeons' (STS) algorithm with conventional coronary artery bypass graft (CABG)/valve surgery in high-risk patients.
  
  
  BACKGROUND
  With advancements in percutaneous coronary interventions (PCIs), some patients requiring coronary revascularization and valve surgery may benefit from a hybrid approach involving initial planned PCI followed by valve surgery, rather than conventional CABG/valve surgery.
  
  
  METHODS
  We retrospectively analyzed 26 consecutive patients with coronary artery and valve disease who underwent planned initial PCI followed by valve surgery during the same hospital stay between September 1997 and August 2003. We calculated the predicted mortality at the time of PCI and compared it with the observed mortality.
  
  
  RESULTS
  There were 12 male and 14 female patients with a median age of 72 years (range 53 to 91 years). Balloon angioplasty was performed in all patients, followed by stenting in 22 (85%) patients. Within a median of 5 days (range 0 to 14 days), 15 patients (58%) underwent primary and 11 patients (42%) underwent re-operative valve surgery. Operative mortality was 1 of 26 patients (3.8%), dramatically lower than the STS-predicted mortality of 22%. Median blood loss was 900 ml, and 22 patients (85%) required blood transfusions. Survival at 1, 3, and 5 years was 78%, 56%, and 44%, respectively.
  
  
  CONCLUSIONS
  Hybrid initial PCI followed by staged valve surgery represents an excellent alternative to conventional CABG/valve surgery in some high-risk patients, particularly those who present in shock after myocardial infarction. Lower mortality rates come at the cost of more bleeding and transfusion requirements.
authors.affiliation: Department of Cardiac Surgery, Boston, MA, USA. john.byrne@vanderbilt.edu
authors.forename: John G
authors.initials: JG
authors.lastname: Byrne
authors.forename: Marzia
authors.initials: M
authors.lastname: Leacche
authors.forename: Daniel
authors.initials: D
authors.lastname: Unic
authors.forename: James D
authors.initials: JD
authors.lastname: Rawn
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Simon
authors.forename: Campbell D
authors.initials: CD
authors.lastname: Rogers
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Cohn
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D015906:Angioplasty, Balloon, Coronary; D006348:Cardiac Surgical Procedures / Q000379:methods*; D015897:Comorbidity; D003327:Coronary Disease / Q000453:epidemiology / Q000601:surgery*; D005260:Female; D006349:Heart Valve Diseases / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012189:Retrospective Studies; D015607:Stents