[Fluorescence diagnostics of tumors].
The intrinsic autofluorescence properties of biological tissues can change depending on alterations induced by pathological processes. In this paper, autofluorescence properties of normal and tumor tissue are presented and possibilities of the application of autofluorescence as a parameter for in situ cancer detection in different organs are discussed. Data obtained during in vivo measurements of normal and pigmented skin autofluorescence are presented. Autofluorescence of experimental tumor (hepatoma A22) was measured to discriminate the optical differences between necrotic, non-necrotic and hemorrhagic areas of tumor and healthy tissue. It was concluded that the uneven distribution of endogenous porphyrins fluorescence in non-necrotic tumor tissue as well as the absence of endogenous porphyrins fluorescence in the small experimental tumors complicated the diagnosis of cancerous tissue based on the autofluorescence measurements.
Rotomskis
Ricardas
R
Laser-induced Research Center, Institute of Oncology, Vilnius University, Lithuania. Ricardas.rotomskis@ff.vu.lt
Streckyte
Giedre
G
D000818:Animals; D003937:Diagnosis, Differential; D005260:Female; D005453:Fluorescence; D006801:Humans; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000175:diagnosis; D051379:Mice; D008962:Models, Theoretical; D009369:Neoplasms / Q000175:diagnosis*; D011166:Porphyrins; D012878:Skin Neoplasms / Q000175:diagnosis; D013050:Spectrometry, Fluorescence
D011166:Porphyrins