title: Fusogenic liposome can be used as an effective vaccine carrier for peptide vaccination to induce cytotoxic T lymphocyte (CTL) response.
abstract: We reported previously that fusogenic liposome (FL) introduced antigen protein encapsulated in the liposome directly into the cytoplasm of the antigen presenting cells, and that it induced immune responses. In the present study, we encapsulated TAX38-46, an HTLV-I derived protein and an antigen peptide model, into FL. The ability to induce effective cytotoxic T lymphocytes (CTL) responses in immunized mice was evaluated. Results showed FL could induce CTL response effectively and suggested that FL is a potential peptide vaccine carrier.
authors.affiliation: Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Sugita
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Jian-Qing
authors.initials: JQ
authors.lastname: Gao
authors.forename: Mariko
authors.initials: M
authors.lastname: Shimokawa
authors.forename: Atushi
authors.initials: A
authors.lastname: Oda
authors.forename: Takako
authors.initials: T
authors.lastname: Niwa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Akashi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: Tadanori
authors.initials: T
authors.lastname: Mayumi
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Nakagawa
mesh_terms: D000818:Animals; D002460:Cell Line; D004337:Drug Carriers / Q000008:administration & dosage*; D005260:Female; D008081:Liposomes; D051379:Mice; D008809:Mice, Inbred C3H; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology; D014611:Vaccination / Q000379:methods; D022223:Vaccines, Subunit / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D022223:Vaccines, Subunit