[Advance in researches on BRCA1].
BRCA1 is one of the most important breast cancer susceptibility genes. It plays key roles in DNA damage repair, cell cycle checkpoint regulation, gene transcription chromatin stability, and cell proliferation. In this paper, advance in basic researches on BRCA1 is reviewed, and the role of BRCA1 in cancer development and progression is discussed, that may facilitate potential clinical application of BRCA1.
Yan
Jing-Hua
JH
Beijing Institute of Biotechnology, Beijing 100 850, China. jinghuayan@hotmail.com
Ye
Qi-Nong
QN
Huang
Cui-Fen
CF
D000818:Animals; D019313:BRCA1 Protein / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002453:Cell Cycle; D049109:Cell Proliferation; D042002:Chromatin Assembly and Disassembly; D004260:DNA Repair; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D014158:Transcription, Genetic
D019313:BRCA1 Protein