[Linear regression analysis of values of the calciuria index, N-telopetide and bone mineral density in patients with osteoporosis].
The authors examined 49 patients (n=49) with primary and secndary osteoporosis incl. 37 women aged 41-58 years and 12 men aged 38-56 years. In all they assessed the 24-hour calciuria index (Ca/creatinine), the aminoterminal N-telopetide of collagen I of the organic matrix (NTx24) and the bone mineral density (BMD) in the first three lumbar vertebrae using quantitative computed tomography (QC).


OBJECTIVE
To find an answer to the questions:1. Is the calciuria index in the 24-hour diuresis a parameter which provides information on osteresorption? 2. Is there a significant negative correlation between values NTx24 and BMD? 3. Is NTx a sensitive parameter of osteoresorption in men and women with primary or secondary osteoporosis?


METHODS
Linear regression analysis.


RESULTS
Correlation coefficients for the correlated groups NTx24 - Ca/creatinine (r = 0.023, p>0.05) and NTx24 - BMD (r = -0.238, p>0.05) were not statistically significant. Statistical significance was recorded in the correlation coefficient for pathologically elevated values of NTx24(zNTx24), correlated with BMD (r = -0.3115, p<0.048).


CONCLUSIONS
1. The calciuria index in the 24-hour diuresis does not provide information on osteoresorption. 2. Between pathologically elevated values of NTx24 and BMD in L1-L3 is a statistically significant negative correlation. 3. NTx is a sensitive parameter of osteresorptioon in men and women with primary and secondary osteoporosis, it reflects the influence of the bone turnover on the density of the bone mineral.
Wendlová
J
J
Osteologická ambulancia, Fakultná NsP akademika L. Dérera, Bratislava.
Mikulecký
M
M
Rácová
K
K
D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D015519:Bone Density; D001862:Bone Resorption; D002118:Calcium / Q000652:urine*; D003094:Collagen / Q000652:urine*; D024042:Collagen Type I; D004231:Diuresis; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000378:metabolism*; D010455:Peptides / Q000652:urine*
D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D003094:Collagen; D002118:Calcium