title: Molecular mechanisms involved in the pathogenesis of septic shock.
abstract: Pathogenesis of the development of sepsis is highly complex and has been the object of study for many years. The inflammatory phenomena underlying septic shock are described in this review, as well as the enzymes and genes involved in the cellular activation that precedes this condition. The most important molecular aspects are discussed, ranging from the cytokines involved and their respective transduction pathways to the cellular mechanisms related to accelerated catabolism and multi-organic failure.
authors.affiliation: Departamento de Biología Celular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico, D.F., Mexico. llopez@ifc.unam.mx
authors.forename: Lucia Nikolaia
authors.initials: LN
authors.lastname: López-Bojórquez
authors.forename: Alejandro Zentella
authors.initials: AZ
authors.lastname: Dehesa
authors.forename: Gustavo
authors.initials: G
authors.lastname: Reyes-Terán
mesh_terms: D016207:Cytokines / Q000378:metabolism; D006439:Hemodynamics; D006801:Humans; D007107:Immune System / Q000502:physiology; D008070:Lipopolysaccharides / Q000276:immunology; D008262:Macrophage Activation; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism; D012772:Shock, Septic / Q000209:etiology* / Q000276:immunology / Q000401:mortality / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology; D013927:Thrombosis; D051193:Toll-Like Receptors
chemical_list: D016207:Cytokines; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors