title: [Frequent genetic deletion of detoxifying enzyme GSTM1 and GSTT1 genes in nasopharyngeal carcinoma patients in Guangxi Province, China].
abstract: OBJECTIVE
  To study the genetic susceptibility to chemical carcinogens of nasopharyngeal carcinoma (NPC) patients in a high-risk area in Guangxi.
  
  
  METHODS
  PCR technique was used to examine the frequency of glutathione S-transferase M1 and T1 gene deletion in a matched case-control study of 91 patients with NPC and 135 control subjects.
  
  
  RESULTS
  The deletion frequency of control subjects was 47.4% (65/135) for GSTM1 and 40.7% (55/135) for GSTT1, whereas that of NPC patients was 61.5% (56/91) for GSTM1 and 59.3% (54/91) for GSTT1 with statistically significant difference between the patients and the controls (P < 0.05 and P < 0.01). Furthermore, the frequency of codeletion of both genes was also higher in NPC patients than the control with statistically significant difference (chi2 = 12.533, P = 0.002).
  
  
  CONCLUSIONS
  In high-risk area, nasopharyngeal carcinoma patients and local residents have high frequency of GSTM1 and/or GSTT1 gene deletion. It suggests that a genetic susceptibility to putative chemical carcinogens may be responsible for NPC clustering in the high-risk area studied.
authors.affiliation: Department of Pathology, Guangxi Medical University, Nanning 530021, China. zhuolindeng@hotmail.com
authors.forename: Zhuo-lin
authors.initials: ZL
authors.lastname: Deng
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Wei
authors.forename: Yun
authors.initials: Y
authors.lastname: Ma
mesh_terms: D016022:Case-Control Studies; D002681:China; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000201:enzymology* / Q000235:genetics
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1