[Disregulation of collateral blood flow and lipid peroxidation abnormalities as a cause of negative influence of emotional stress on the course of cerebral ischemia].
Under normal conditions, local brain blood flow in young rats determined their individual resistance to ischemia and emotional stress. In low-activity rats predisposed to emotional stress, a level of blood flow was significantly (p<0.05) higher, comparing to high-active animals resistant to emotional stress. An exposure of rats to aggressive- and conflict situation for 18 h was followed by pronounced emotional stress accompanied by the reduction of local cerebral blood flow by 10-15% and abolished individual differences in resistance to cerebral ischemia. Collateral blood flow did not develop in pre-stressed rats during the acute period of cerebral ischemia. The mortality rate reached 90% independently of the animal emotional resistance. In ischemia after 2 h exposure to stress, differences were revealed in the intensity of lipid peroxidation in the brain of animals with divergent emotional resistance. Comparing to stress-resistant rats, in stress-predisposed animals, a level of malonic dialdehyde in the amygdale basal nuclei was 2-fold lower. The results suggest the differences in stress response in animals with various resistance to the effect of adverse factors.
Ganushkina
I V
IV
Koplik
E V
EV
Konorova
I L
IL
Antelava
A L
AL
Pirogova
G V
GV
D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D002545:Brain Ischemia / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D003097:Collateral Circulation / Q000502:physiology*; D004195:Disease Models, Animal; D004777:Environment; D005609:Free Radicals / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000503:physiopathology*
D005609:Free Radicals