Transcription factors and mitogen-activated protein kinases as molecular targets for chemoprevention with anti-inflammatory phytochemicals.
Chemoprevention refers to the use of nontoxic chemical substances to inhibit, reverse, or retard tumorigenesis. Numerous compounds derived from edible plants have been reported to interfere with a specific stage of the carcinogenic process. Some anti-inflammatory phytochemicals with cyclooxygenase-2 inhibitory activity have been found to exert chemopreventive properties by targeting intracellular signaling molecules (recently reviewed by Y.-J. Surh, Nature Reviews Cancer, 3: 768-780, 2003). These include mitogen-activated protein kinases and transcription factors, such as NF-kappaB and AP-1.
Surh
Young-Joon
YJ
College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742, South Korea. surh@plaza.snu.ac.kr
Na
Hye-Kyung
HK
Lee
Seung Sei
SS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D051546:Cyclooxygenase 2; D006801:Humans; D008565:Membrane Proteins; D020928:Mitogen-Activated Protein Kinases / Q000187:drug effects / Q000378:metabolism*; D008517:Phytotherapy; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects / Q000235:genetics; D014157:Transcription Factors / Q000187:drug effects / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008565:Membrane Proteins; D014157:Transcription Factors; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D020928:Mitogen-Activated Protein Kinases