Ethnic differences in cerebral venous thrombosis.
BACKGROUND
Cerebral venous thromboses (CVT) with distinct clinical presentations have been shown worldwide. However, there is little information regarding race-ethnic differences in this disease.


METHODS
We prospectively studied 50 CVT patients from Brazil, comparing clinical and laboratory data among white (W) and African-Brazilian (AB) patients.


RESULTS
Seventy percent of the patients were female, 26 W and 23 AB, mean age 34.7 years. Multiple sinus CVT, deep CVT and worse outcome were significantly more frequent in AB than in W patients. There was a trend towards a higher frequency of factor V Leiden and prothrombin mutation in W than in AB, and of protein C deficiency in AB.


CONCLUSIONS
CVT was more severe in AB patients than in W patients. Race-ethnic differences may account for the heterogeneous distribution of inherited thrombophilia in this series.
Camargo
Erica Cristina Sá de
EC
Department of Neurology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. ecamargo@partners.org
Massaro
Ayrton Roberto
AR
Bacheschi
Luiz Alberto
LA
D'Amico
Elbio Antônio
EA
Villaça
Paula Ribeiro
PR
Bassitt
Rogério Pastore
RP
Gualandro
Sandra Fátima
SF
Bendit
Israel
I
Scaff
Milberto
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D044383:Black People; D001938:Brazil / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000208:ethnology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D014505:Urban Population; D020246:Venous Thrombosis / Q000208:ethnology*; D044465:White People