Anti-inflammatory activity of Indian black tea (Sikkim variety).
In this study, the anti-inflammatory (in reference to the cardinal signs of inflammation) and other related pharmacological activities of the hot water extract of black tea (Camellia sinensis, Sikkim variety) were evaluated along with certain standard drugs. The extract showed significant inhibitory activity against carrageenin, histamine, serotonin and prostaglandin-induced pedal inflammation. The extract inhibited exudative inflammation. The tea extract also inhibited cotton pellet-induced granuloma formation and adjuvant-induced polyarthritis. Black tea extract showed significant inhibition against glucose oxidase-mediated inflammation. The present observations establish the efficacy of this particular variety of black tea, both in the exudative and proliferative forms and as well in the chronic phase of inflammation.
Nag Chaudhuri
A K
AK
Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Raja S.C. Mallick Road, Calcutta 700032, India.
Karmakar
Sanmoy
S
Roy
Dilip
D
Pal
Siddhartah
S
Pal
Mintu
M
Sen
Tuhinadri
T
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy* / Q000473:pathology; D007194:India; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012819:Sikkim; D013662:Tea
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D013662:Tea