Highly enantioselective allylation of aldehydes catalyzed by indium(III)-PYBOX complex.
A chiral indium(III)-PYBOX complex prepared from indium triflate and chiral PYBOX has been discovered to effect high enantioselectivities in the addition of allyltributyl stannane to aldehydes. The allylation of a variety of aromatic, alpha,beta-unsaturated, and aliphatic aldehydes resulted in good yields and high enantioselectivities (up to 94% ee).
Lu
Jun
J
Department of Chemistry, National Unviversity of Singapore, 3 Science Drive 3, Singapore 117543.
Ji
Shun-Jun
SJ
Teo
Yong-Chua
YC
Loh
Teck-Peng
TP
D000447:Aldehydes / Q000737:chemistry*; D000498:Allyl Compounds / Q000737:chemistry*; D002384:Catalysis; D007204:Indium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D000498:Allyl Compounds; D009942:Organometallic Compounds; D010080:Oxazoles; D011725:Pyridines; C510741:indium(III)-PYBOX; D007204:Indium