[Atrophic gastritis caused by Helicobacter pylori as a precancer disease].
1-3% persons infected with H. pylori develop atrophic gastritis annually. Probability of stomach mucous membrane atrophy in such patients is 50%. H. pylori increases risk of carcinoma development 4-6 times. Experimental infection of mice and mongol gebrils results in neoplasia. CagA- and VacA-positive H. pylori strains have the most pronounced effect in relation to enhancement of inflammation and mucous membrane atrophy. The association was noticed between certain human gene alleles IL-1, IL-10, TNF-alpha on the one hand, incidence of stomach carcinoma and atrophic gastritis with hypochlorohydria, on the other. Results of efficiency of H. pylori treatment in inverse development of gastritis are contradictory. Nevertheless, such therapy is studied as a possible method of carcinoma prophylaxis.
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D000818:Animals; D005753:Gastric Mucosa / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000150:complications* / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D051379:Mice; D011230:Precancerous Conditions / Q000473:pathology*; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology