Pd-catalyzed one-pot multicomponent coupling reaction for the highly regioselective synthesis of polysubstituted benzenes.
[Reaction: see text] Tetrasubstituted benzenes can be efficiently synthesized in a regioselective manner from alkynes and 2-bromoacrylates by palladium-catalyzed cascade Sonogashira coupling-benzannulation reaction.
Xi
Chanjuan
C
Key Laboratory for Bioorganic Phosphorus Chemistry of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China. cjxi@tsinghua.edu.cn
Chen
Chao
C
Lin
Jie
J
Hong
Xiaoyin
X