[A preliminary report on treatment of myelodysplastic syndrome with cyclosporin a and androgen].
The study was aimed to explore clinical result of cyclosporin A (CsA) and androgens for treatment of myelodysplastic syndrome (MDS) with refractory anemia. Four cases of MDS-RA were treated with CsA and androgens, while the changes of blood counts, bone marrow and chromosome were observed. The results showed that substantial hematological response was observed in all four patients, that their anemia improved and all transfusion-dependent patients achieved transfusion independence. In conclusion, CsA and Adr therapy was well tolerated. CsA and Adr therapy offer an alternative treatment of MDS with RA. The mechanisms of the benifical effect from this therapy remain the subject of an ongoing study.
Wang
Jing-Wen
JW
Department of Hematology, General Hospital, Beijing Military Area, Beijing 100700, China.
Ning
Feng
F
Liu
Xiao-Dong
XD
Lou
Jin-Xing
JX
Chen
Peng
P
Liu
Bing
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000728:Androgens / Q000627:therapeutic use*; D001772:Blood Cell Count; D016572:Cyclosporine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000188:drug therapy*; D016896:Treatment Outcome
D000728:Androgens; D006454:Hemoglobins; D007166:Immunosuppressive Agents; D016572:Cyclosporine