title: Trazodone influence on rat sera beta-endorphins level.
abstract: Some 25 years ago it was found that parts of CNS could produce strong analgesic response on little morphine quantities. Later studies proved the existence for dozen of morphine-like substances, called opioids, which are normally produced in the brain. The most important are endorphins, met- and leu-encephalin and dinorphin produced both in hypothalamus and pituitary gland. The aim of our study was to found whether and how strong produce of beta-endorphins is to be expected when psychotropic drugs are used. Trazodon as antidepressant was used, and RIA technique for quantification of sera beta-endorphins. The results showed significant difference in rat sera beta-endorphins between certain days of drug application. These studies showed that beta-endorphins could be of great importance, used as markers for evaluation of patient treatment and eventual abuse of psychotropic drugs.
authors.affiliation: Institute for Physiology and Biochemistry, University of Sarajevo, Medical faculty, Bosnia and Herzegovina.
authors.forename: Radivoj
authors.initials: R
authors.lastname: Jadrić
authors.forename: Irfan
authors.initials: I
authors.lastname: Zulić
authors.forename: Sabaheta
authors.initials: S
authors.lastname: Hasić
authors.forename: Emina
authors.initials: E
authors.lastname: Kiseljaković
authors.forename: Belma
authors.initials: B
authors.lastname: Zecević
authors.forename: Jovan
authors.initials: J
authors.lastname: Radovanović
authors.forename: Emina
authors.initials: E
authors.lastname: Ićindić-Nakas
authors.forename: Mira
authors.initials: M
authors.lastname: Winterhalter-Jadrić
mesh_terms: D000818:Animals; D051381:Rats; D017208:Rats, Wistar; D014196:Trazodone / Q000494:pharmacology*; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D001615:beta-Endorphin; D014196:Trazodone