title: Peri-ictal SPECT and surgical treatment for intractable epilepsy related to schizencephaly.
abstract: The authors evaluated four patients with schizencephaly who underwent subtraction ictal SPECT coregistered to MRI (SISCOM) prior to epilepsy surgery. Three patients had a SISCOM alteration that was concordant with the epileptic brain tissue. Two of these patients were rendered seizure-free and one individual experienced a significant reduction in seizures. The patient with an indeterminate SISCOM had an unfavorable outcome. SISCOM is useful in evaluating patients with schizencephaly for epilepsy surgery.
authors.affiliation: Mayo Clinic, 200 First Street SW, Rochester, MN 55905. gcascino@mayo.edu.
authors.forename: G D
authors.initials: GD
authors.lastname: Cascino
authors.forename: J R
authors.initials: JR
authors.lastname: Buchhalter
authors.forename: J I
authors.initials: JI
authors.lastname: Sirven
authors.forename: E L
authors.initials: EL
authors.lastname: So
authors.forename: J F
authors.initials: JF
authors.lastname: Drazkowski
authors.forename: R S
authors.initials: RS
authors.lastname: Zimmerman
authors.forename: C
authors.initials: C
authors.lastname: Raffel
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000098:blood supply / Q000000981:diagnostic imaging / Q000601:surgery; D002560:Cerebrovascular Circulation; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D006801:Humans; D007859:Learning Disabilities / Q000000981:diagnostic imaging / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000000981:diagnostic imaging / Q000209:etiology; D010291:Paresis / Q000000981:diagnostic imaging / Q000209:etiology; D011184:Postoperative Period; D011300:Preoperative Care; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome