Localization of human X chromosomal mental retardation (MRX) genes in chicken and comparison with the chicken genome sequence data.
In an ongoing study human X chromosomal mental retardation genes (MRX) were mapped in the chicken genome. Up to now the homologs of 13 genes were localized by FISH techniques. Four genes from HSAXp (TM4SF2, RSK2/RPS6KA3, NLGN4, ARX) map to GGA1q13-->q31, and seven genes from HSAXq (OPHN1, AGTR2, ARHGEF6, PAK3, FACL4/ACS4, FMR2, ATRX) to GGA4p. The gene-rich region of HSAXq28 proved to be much less conserved. GDI1 localized to GGA1pter and SLC6A8 to a mid-sized microchromosome. The order of the genes was determined from the newly available genome sequence data from chicken, which reveals exact colinearity between the genes in HSAXp and GGA1q13-->q31, but completely scrambled gene order between the genes with common synteny from HSAXq and GGA4p. This result supports the hypothesis that the human X chromosome is a real ancient autosomal linkage group.
Kohn
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Department of Human Genetics, University Ulm, Ulm, Germany.
Kehrer-Sawatzki
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H
Hameister
H
H
D000818:Animals; D002645:Chickens / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods; D002875:Chromosomes / Q000235:genetics; D041321:Chromosomes, Human, X / Q000235:genetics*; D020224:Expressed Sequence Tags; D006801:Humans; D038901:X-Linked Intellectual Disability / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid