title: The effect of coenzyme Q10 and vitamin E on the regeneration of skeletal muscles in pigs.
abstract: The aim of the study was to observe the effect of coenzyme Q10 and vitamin E supplementation on the course of the regeneration process of the longissimus lumborum muscle after bupivacaine-induced myonecrosis as well as to determine the correlation between the level of those substances in plasma and their levels in damaged and non-damaged muscular tissue in pigs. The obtained results indicate that the course of regeneration of a damaged muscle is affected to a higher extent by coenzyme Q10 than by vitamin E. The administration of coenzyme Q10 and vitamin E has a significant impact on the increase in the level of those substances in damaged muscles and plasma of animals.
authors.affiliation: Department of Pathology and Pharmacology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Otrocka-Domagała
authors.forename: T
authors.initials: T
authors.lastname: Rotkiewicz
authors.forename: J
authors.initials: J
authors.lastname: Karpińska
authors.forename: A
authors.initials: A
authors.lastname: Purzyńska-Pugacewicz
authors.forename: B
authors.initials: B
authors.lastname: Kasperowicz
authors.forename: A
authors.initials: A
authors.lastname: Mikołajczyk
authors.forename: I
authors.initials: I
authors.lastname: Babińska
mesh_terms: D000779:Anesthetics, Local / Q000633:toxicity; D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism; D002045:Bupivacaine / Q000633:toxicity; D003067:Coenzymes; D005260:Female; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D009135:Muscular Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary*; D009336:Necrosis; D012038:Regeneration / Q000502:physiology*; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced / Q000503:physiopathology*; D014451:Ubiquinone / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood
chemical_list: D000779:Anesthetics, Local; D000975:Antioxidants; D003067:Coenzymes; D014451:Ubiquinone; D014810:Vitamin E; C024989:coenzyme Q10; D002045:Bupivacaine