title: [Conservative and surgical treatment of neurotrophic keratopathy].
abstract: Neurotrophic keratopathy is one of the most challenging conditions among the disorders of wound healing of the ocular surface. In addition to bilateral assessment of corneal sensitivity, tear status and lid function must be analyzed and treated by unpreserved artificial tears and adequate lid surgery. Further conservative treatment options include hyaluronic acid and dexpanthenol as well as autologous serum. Application of recombinant growth factors (especially NGF) represents an interesting perspective. Concerning surgical interventions, temporary or permanent occlusion of the lacrimal punctum may be accompanied by lateral tarsorrhaphy which is easy to perform, potentially reversible, and in most cases successful. Depending on the type of wound healing disorder amniotic membrane transplantation may be helpful either as basal membrane transplant (graft) or as a patch, or in combination (sandwich). A tectonic keratoplasty a chaud should typically be combined with a simultaneous amniotic membrane patch and/or a lateral tarsorrhaphy to avoid persistent epithelial defects.
authors.affiliation: Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg, Erlangen. berthold.seitz@augen.imed.uni-erlangen.de
authors.forename: B
authors.initials: B
authors.lastname: Seitz
authors.forename: M
authors.initials: M
authors.lastname: Grüterich
authors.forename: C
authors.initials: C
authors.lastname: Cursiefen
authors.forename: F E
authors.initials: FE
authors.lastname: Kruse
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000650:Amnion / Q000637:transplantation; D003315:Cornea / Q000294:innervation* / Q000502:physiology / Q000601:surgery; D016039:Corneal Transplantation; D003320:Corneal Ulcer / Q000209:etiology / Q000628:therapy; D019573:Epithelium, Corneal; D005143:Eyelids / Q000502:physiology / Q000601:surgery; D005451:Fluorescein Angiography; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D007634:Keratitis / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D007765:Lacrimal Apparatus / Q000601:surgery; D020932:Nerve Growth Factor / Q000627:therapeutic use; D009883:Ophthalmic Solutions; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D044967:Serum; D014945:Wound Healing
chemical_list: D000276:Adjuvants, Immunologic; D009883:Ophthalmic Solutions; D010205:Pantothenic Acid; C007288:dexpanthenol; D006820:Hyaluronic Acid; D020932:Nerve Growth Factor