Neonatal meningitis caused by coxsackievirus B5.
Enteroviral infections are more severe in neonates than in older children, and coxsackievirus B is most frequently associated with severe neonatal disease. We summarize the course and clinical data of four neonates with meningitis caused by coxsackievirus B5. Their clinical symptoms and signs were persistent fever, poor appetite, and decreased activity, with vomiting in two. Laboratory analysis of cerebrospinal fluid revealed the following: white blood count, 340-660/mm3; red blood count, 0-250/ mm3; glucose level, 47-59 mg/dl; and total protein level, 70-106 mg/dl. Echocardiography showed normal heart function. Final bacterial cultures of the cerebrospinal fluid showed no growth, whereas viral cultures showed coxsackievirus B5. All patients recovered without intravenous immunoglobulin. No complications occurred at 6-month follow-up.
Hu
Jui-Ming
JM
Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan.
Su
Pen-Hua
PH
Chan
Chia-Jung
CJ
Chen
Jia-Yuh
JY
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000821:virology; D003384:Coxsackievirus Infections / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D004562:Electrocardiography; D029822:Enterovirus B, Human / Q000302:isolation & purification*; D005334:Fever / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008587:Meningitis, Viral / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013624:Taiwan; D016896:Treatment Outcome; D014839:Vomiting / Q000209:etiology
D000900:Anti-Bacterial Agents