Simultaneous occurrence of medullary and papillary carcinomas of the thyroid gland with metastases of papillary carcinoma to the cervical lymph nodes and the coinciding small B-cell lymphocytic lymphoma of the lymph nodes--a case report.
We report a case of a simultaneous occurrence of medullary and papillary carcinomas of the thyroid gland with metastases of a papillary carcinoma to the cervical lymph nodes and a concurrent small B-cell lymphocytic lymphoma revealed in the lymph nodes examined in a 71-year-old woman. The diagnosis was based on microscopic examination of surgical specimens and supported by immunohistochemistry. Additionally, P53 and RET mutation analysis was performed. In this case, the coincidence of medullary and papillary carcinomas of the thyroid gland may account for a true composite tumor. The coexistence of a small B-cell lymphoma in our patient may be explained by irradiation treatment undergone during the adolescence.
Bocian
Artur
A
Department of Surgery, Holy Cross Cancer Center, Kielce. abocian@mp.pl
Kopczyński
Janusz
J
Rieske
Piotr
P
Piaskowski
Sylwester
S
Słuszniak
Janusz
J
Kupnicka
Dorota
D
Góźdź
Stanisław
S
Kowalska
Aldona
A
Sygut
Jacek
J
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D018276:Carcinoma, Medullary / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000235:genetics / Q000556:secondary*; D004252:DNA Mutational Analysis; D005260:Female; D016158:Genes, p53; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology*; D008207:Lymphatic Metastasis; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D009333:Neck; D009378:Neoplasms, Multiple Primary; D016609:Neoplasms, Second Primary / Q000473:pathology*; D015513:Oncogene Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*
D014408:Biomarkers, Tumor; D015513:Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human; D020794:Receptor Protein-Tyrosine Kinases