title: Simultaneous occurrence of medullary and papillary carcinomas of the thyroid gland with metastases of papillary carcinoma to the cervical lymph nodes and the coinciding small B-cell lymphocytic lymphoma of the lymph nodes--a case report.
abstract: We report a case of a simultaneous occurrence of medullary and papillary carcinomas of the thyroid gland with metastases of a papillary carcinoma to the cervical lymph nodes and a concurrent small B-cell lymphocytic lymphoma revealed in the lymph nodes examined in a 71-year-old woman. The diagnosis was based on microscopic examination of surgical specimens and supported by immunohistochemistry. Additionally, P53 and RET mutation analysis was performed. In this case, the coincidence of medullary and papillary carcinomas of the thyroid gland may account for a true composite tumor. The coexistence of a small B-cell lymphoma in our patient may be explained by irradiation treatment undergone during the adolescence.
authors.affiliation: Department of Surgery, Holy Cross Cancer Center, Kielce. abocian@mp.pl
authors.forename: Artur
authors.initials: A
authors.lastname: Bocian
authors.forename: Janusz
authors.initials: J
authors.lastname: Kopczyński
authors.forename: Piotr
authors.initials: P
authors.lastname: Rieske
authors.forename: Sylwester
authors.initials: S
authors.lastname: Piaskowski
authors.forename: Janusz
authors.initials: J
authors.lastname: Słuszniak
authors.forename: Dorota
authors.initials: D
authors.lastname: Kupnicka
authors.forename: Stanisław
authors.initials: S
authors.lastname: Góźdź
authors.forename: Aldona
authors.initials: A
authors.lastname: Kowalska
authors.forename: Jacek
authors.initials: J
authors.lastname: Sygut
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D018276:Carcinoma, Medullary / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000235:genetics / Q000556:secondary*; D004252:DNA Mutational Analysis; D005260:Female; D016158:Genes, p53; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology*; D008207:Lymphatic Metastasis; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D009333:Neck; D009378:Neoplasms, Multiple Primary; D016609:Neoplasms, Second Primary / Q000473:pathology*; D015513:Oncogene Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D015513:Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human; D020794:Receptor Protein-Tyrosine Kinases