Interaction of polypyridyl ruthenium (II) complex containing asymmetric ligand with DNA.
A novel asymmetric bidentate ruthenium (II) complex, [Ru(bpy)(2)(PYNI)](2+) (bpy=2,2'-bipyridine, PYNI=2-(2'-pyridyl)naphthoimidazole), has been synthesized and characterized by elemental analysis, ES-MS (electrospray mass spectra) and (1)H NMR. The electrochemical behaviors of this complex were studied by cyclic voltammetry. DNA interaction studies suggest that [Ru(bpy)(2)(PYNI)](2+) binds to calf thymus DNA (CT-DNA) in an intercalative mode. Interestingly, this new Ru(II) complex has also been found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation.
Liu
Yun-Jun
YJ
Department of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China.
Chao
Hui
H
Tan
Li-Feng
LF
Yuan
Yi-Xian
YX
Wei
Wei
W
Ji
Liang-Nian
LN
D000818:Animals; D002417:Cattle; D004247:DNA / Q000187:drug effects*; D066298:In Vitro Techniques; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D049449:Luminescence; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010777:Photochemistry; D010957:Plasmids / Q000187:drug effects; D012428:Ruthenium; D021241:Spectrometry, Mass, Electrospray Ionization; D013053:Spectrophotometry; D013816:Thermodynamics; D014783:Viscosity
D007364:Intercalating Agents; D008024:Ligands; D009942:Organometallic Compounds; D012428:Ruthenium; D004247:DNA