title: DNA methylation 40 years later: Its role in human health and disease.
abstract: A long path, initiated more than 40 years ago, has led to a deeper understanding of the complexity of gene regulation in eukaryotic genomes. In addition to genetic mechanisms, the imbalance in the epigenetic control of gene expression may profoundly alter the finely tuned machinery leading to gene regulation. Here, we review the impact of the studies on DNA methylation, the "primadonna" in the epigenetic scenario, on the understanding of basic phenomena, such as X inactivation and genomic imprinting. The effect of deregulation of DNA methylation on human health, will be also discussed. Finally, an attempt to predict future directions of this rapidly evolving field has been proposed, with the certainty that, fortunately, science is always better than predictions.
authors.affiliation: Department of Biomorphological and Functional Sciences, University of Naples "Federico II", Naples, Italy. mscarano@unina.it
authors.forename: Maria Irene
authors.initials: MI
authors.lastname: Scarano
authors.forename: Maria
authors.initials: M
authors.lastname: Strazzullo
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Matarazzo
authors.forename: Maurizio
authors.initials: M
authors.lastname: D'Esposito
mesh_terms: D019175:DNA Methylation; D004303:Dosage Compensation, Genetic; D044127:Epigenesis, Genetic / Q000502:physiology*; D030342:Genetic Diseases, Inborn / Q000235:genetics* / Q000378:metabolism; D018392:Genomic Imprinting / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000503:physiopathology