Circulating pregnancy-associated plasma protein A is not an early marker of acute myocardial infarction.
OBJECTIVE
The purpose of this study was to assess whether serum levels of pregnancy-associated plasma protein A (PAPP-A) are elevated early in patients with acute myocardial infarction (AMI).


METHODS
We measured serum levels of PAPP-A in 80 patients with AMI and in 80 age-matched healthy control subjects. The mean (+/-SEM) time from onset of symptoms to blood sampling was 6.3 +/- 2.8 h in the group with AMI.


RESULTS
The PAPP-A levels did not differ between the control group and the AMI group (1.24 +/- 0.07 vs. 1.29 +/- 0.02 mIU/l; P = 0.54).


CONCLUSIONS
Measurement of serum PAPP-A does not seem to be a useful early marker for AMI.
Dominguez-Rodriguez
Alberto
A
Department of Cardiology, Coronary Care Unit, Hospital Universitario de Canarias, Ofra s/n La Cuesta E-38320, Tenerife, Spain. adrvdg@hotmail.com
Abreu-Gonzalez
Pedro
P
Garcia-Gonzalez
Martín
M
Ferrer
Julio
J
Vargas
Manuel
M
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*
D015415:Biomarkers; D011266:Pregnancy-Associated Plasma Protein-A