title: [Growth or somatotrophic hormone: new perspectives in isolated GH deficiency after description of the mutation in the GHRH receptor gene in individuals of Itabaianinha County, Brazil].
abstract: In addition to stimulating body growth, growth or somatotrophic hormone plays an important role in metabolism, body composition, lipid profile, cardiovascular status and longevity. Its control is multiregulated by hormones, metabolites and hypothalamic peptides. Obtained data of the isolated growth hormone deficiency (IGHD) after the description of the IVS1+1G-->A GHRH receptor gene mutation in individuals of Itabaianinha County are reviewed. New perspectives about the growth hormone resistance model, the importance of GHRH in the control of GH secretion, the frequency of GHRH-R gene mutations, the diagnostic relevance of IGF-I and the metabolic, cardiovascular and quality of life findings are approached.
authors.affiliation: Serviço de Endocrinologia, Hospital Universitário, Universidade Federal de Sergipe, Aracaju, SE.
authors.forename: Anita Hermínia O
authors.initials: AH
authors.lastname: Souza
authors.forename: Roberto
authors.initials: R
authors.lastname: Salvatori
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Martinelli
authors.forename: Walter M O
authors.initials: WM
authors.lastname: Carvalho
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Menezes
authors.forename: Elenilde S de A
authors.initials: ES
authors.lastname: Barretto
authors.forename: José A S
authors.initials: JA
authors.lastname: Barreto Filho
authors.forename: Marta R S de
authors.initials: MR
authors.lastname: Alcântara
authors.forename: Carla R P
authors.initials: CR
authors.lastname: Oliveira
authors.forename: Paula R S de
authors.initials: PR
authors.lastname: Alcântara
authors.forename: Roberto J R
authors.initials: RJ
authors.lastname: Ramalho
authors.forename: Hélio A
authors.initials: HA
authors.lastname: Oliveira
authors.forename: Ivana B de
authors.initials: IB
authors.lastname: Lima
authors.forename: Jamille N
authors.initials: JN
authors.lastname: Carneiro
authors.forename: Marcos M
authors.initials: MM
authors.lastname: Santos
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Gill
authors.forename: Peter E
authors.initials: PE
authors.lastname: Clayton
authors.forename: Manuel H A
authors.initials: MH
authors.lastname: Oliveira
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil; D002648:Child; D013006:Growth Hormone / Q000172:deficiency*; D013007:Growth Hormone-Releasing Hormone / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D008875:Middle Aged; D009154:Mutation; D018013:Receptors, Neuropeptide / Q000235:genetics*; D018017:Receptors, Pituitary Hormone-Regulating Hormone / Q000235:genetics*
chemical_list: D018013:Receptors, Neuropeptide; D018017:Receptors, Pituitary Hormone-Regulating Hormone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; C048250:somatotropin releasing hormone receptor