title: Human interferons alpha, beta and omega.
abstract: Type I interferons (IFNs), IFN-alpha, IFN-beta, IFN-omega, IFN-delta and IFN-tau are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-alpha/beta with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.
authors.affiliation: Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Bekisz
authors.forename: Hana
authors.initials: H
authors.lastname: Schmeisser
authors.forename: Jessica
authors.initials: J
authors.lastname: Hernandez
authors.forename: Neil D
authors.initials: ND
authors.lastname: Goldman
authors.forename: Kathryn C
authors.initials: KC
authors.lastname: Zoon
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007370:Interferon Type I / Q000502:physiology*; D016898:Interferon-alpha / Q000502:physiology* / Q000627:therapeutic use; D016899:Interferon-beta / Q000502:physiology* / Q000627:therapeutic use; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry; D017433:Protein Structure, Secondary; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D007370:Interferon Type I; D016898:Interferon-alpha; D010455:Peptides; C063743:interferon omega 1; D016899:Interferon-beta