Ionic liquids as advantageous solvents for headspace gas chromatography of compounds with low vapor pressure.
The potential of ionic liquids as solvents for headspace gas chromatography was investigated. Three compounds with boiling points above 200 degrees C were selected to demonstrate the feasibility of the concept described. 2-Ethylhexanoic acid, formamide, and tri-n-butylamine as examples of acidic, neutral, and basic analytes were dissolved in acidic 1-n-butyl-3-methylimidazolium hydrogen sulfate (1), neutral 1-n-butyl-2,3-dimethylimidazolium dicyanamide (2), and 2 containing 1,8-diazabicyclo[5.4.0]undec-7-ene to adjust basic conditions. All analytes could be determined with limits of detection and limits of quantification in the low-ppm concentration range.
Andre
M
M
Sandoz GmbH, Biochemiestrasse 10, 6250 Kundl, Austria, Immodal Pharmaka GmbH, Bundesstrasse 44, 6111 Volders, Austria. max.andre@gx.novartis.com
Loidl
J
J
Laus
G
G
Schottenberger
H
H
Bentivoglio
G
G
Wurst
K
K
Ongania
K-H
KH
D000667:Ampicillin / Q000302:isolation & purification; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D002082:Butylamines / Q000737:chemistry; D002208:Caproates / Q000737:chemistry; D002849:Chromatography, Gas / Q000379:methods*; D019818:Clavulanic Acid / Q000302:isolation & purification; D005559:Formamides / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D007477:Ions; D010401:Penicillin G Benzathine / Q000302:isolation & purification; D011312:Pressure; D012997:Solvents / Q000737:chemistry*
C516563:1-n-butyl-2,3-dimethylimidazolium dicyanamide; C516562:1-n-butyl-3-methylimidazolium hydrogen sulfate; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002082:Butylamines; D002208:Caproates; D005559:Formamides; D007093:Imidazoles; D007477:Ions; D012997:Solvents; C040668:2-ethylhexanoic acid; D019818:Clavulanic Acid; C031066:formamide; D000667:Ampicillin; C036355:tributylamine; C031033:1,8-diazabicyclo(5.4.0)undec-7-ene; D010401:Penicillin G Benzathine