title: High prevalence of respiratory viral infections in patients hospitalized in an intensive care unit for acute respiratory infections as detected by nucleic acid-based assays.
abstract: Forty-seven bronchoalveolar lavages (BAL) were obtained from 41 patients with acute pneumonia attending an intensive care unit. By molecular diagnosis, 30% of total BAL and 63% of bacteria-negative BAL were positive for respiratory viruses. Molecular detection allows for high-rate detection of respiratory viral infections in adult patients suffering from severe pneumonia.
authors.affiliation: Hôpital Européen Georges Pompidou, and Unité INSERM 430, Institut de Recherches Biomédicales des Cordeliers, Faculté de Médecine Broussais-Hôtel Dieu, Université Pierre et Marie Curie, Paris, France. jerome.le-goff@egp.ap-hop-paris.fr
authors.forename: Jérôme
authors.initials: J
authors.lastname: Legoff
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Guérot
authors.forename: Angélique
authors.initials: A
authors.lastname: Ndjoyi-Mbiguino
authors.forename: Mathieu
authors.initials: M
authors.lastname: Matta
authors.forename: Ali
authors.initials: A
authors.lastname: Si-Mohamed
authors.forename: Laurent
authors.initials: L
authors.lastname: Gutmann
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Fagon
authors.forename: Laurent
authors.initials: L
authors.lastname: Bélec
mesh_terms: D000208:Acute Disease; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis / Q000302:isolation & purification; D005260:Female; D006760:Hospitalization; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods*; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D014777:Virus Diseases / Q000453:epidemiology* / Q000821:virology; D014780:Viruses / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral