[The effect of platelet-rich plasma on the distraction osteogenesis].
OBJECTIVE
To observe the effect of the platelet-rich plasma (PRP) on osteogenesis during bone distraction.


METHODS
The osteoblasts were cultured in vitro. The rabbits were used as the animal model of distraction osteogenesis. The proliferation of osteoblasts was analysed through MTT methods. The osteogenesis was observed by histochemical and histoimmunochemical methods.


RESULTS
PRP stimulated the proliferation of osteoblasts and facilitated distraction osteogenesis.


CONCLUSIONS
PRP could accelerate the osteogenesis during bone distraction. The application of PRP in clinical practice might shorten the period of distraction osteogenesis.
Luo
Quan-feng
QF
Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology, Beijing 100081, China. lqf6668@163.com
Wang
Xing
X
Wang
Xiao-xia
XX
Yin
Biao
B
Li
Zi-li
ZL
Liang
Cheng
C
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002478:Cells, Cultured; D007150:Immunohistochemistry; D008297:Male; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D010012:Osteogenesis / Q000502:physiology; D019857:Osteogenesis, Distraction; D010976:Platelet Count; D011817:Rabbits