title: Dissociative identity disorder associated with mania and change in handedness.
abstract: OBJECTIVE
  To investigate the overlap between dissociative and bipolar disorders with reference to their neurophysiological foundations.
  
  
  BACKGROUND
  Case reports of anomalous lateralization and shifts in handedness associated with both affective and dissociative conditions have intermittently surfaced in the literature. The two disorders are, however, usually considered to be distinct psychopathological entities.
  
  
  METHODS
  A case of co-occurring bipolar disorder and dissociative identity disorder (DID) is presented.
  
  
  RESULTS
  The "switch" in personality coincided with manic or hypomanic symptoms and was associated with a change in handedness.
  
  
  CONCLUSIONS
  A parallel between the "personality" shifts that characterize DID and the mood fluctuations that underlie bipolar disorder is drawn, suggesting some nosological overlap between the two disorders. The possibility that these two psychiatric conditions share a similar neurophysiological architecture is also raised.
authors.affiliation: MRC/UCT Human Genetics Research Unit, University of Cape Town Medical School, Observatory, 7925, South Africa. js@cormack.uct.ac.za
authors.forename: Jonathan
authors.initials: J
authors.lastname: Savitz
authors.forename: Mark
authors.initials: M
authors.lastname: Solms
authors.forename: Elize
authors.initials: E
authors.lastname: Pietersen
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Ramesar
authors.forename: Pierre
authors.initials: P
authors.lastname: Flor-Henry
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000150:complications*; D009105:Dissociative Identity Disorder / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D009483:Neuropsychological Tests; D010551:Personality