[Markers of inflammation, autoantibodies to neurospecific antigens and outcome in patients with acute ischemic stroke].
To identify biochemical markers for carotid stroke outcome, blood serum levels of inflammation markers (C-reactive protein, orosomucoid, soluble p-selectin) and autoantibodies (AAB) to neurospecific antigens (glial fibrillary acidic protein, neuron specific enolase, S-100 protein) were studied in 27 patients (mean age 64 +/- 6 years) with acute ischemic stroke in inner carotid artery system on day 1-2 and 21 of the disease onset. To day 21, patients with good rehabilitation of neurological functions (group 1) demonstrated a decrease of C-reactive protein and soluble p-selectin concentrations, and unfavorable disease course was associated with a significant (p<0.05) increase of concentrations of these indices. On day 1 and 7, a level of AAT to glial fibrillary acidic protein was higher (p<0.05) in group 1 than in that with minimal rehabilitation and to day 21 it decreased relatively the baseline level. At the same time, patients with minimal rehabilitation had a stable AAT level. On day 7, the AAT level correlated with expression of neurological deficit on day 21 (r=0.510; p=0.019). No stroke-course-dependent differences were found in dynamics of orosomucoid as well as of AAT to neuron specific enolase and S-100 protein levels.
Ruleva
N Iu
NIu
Kuzin
V M
VM
Martynov
M Iu
MIu
Kamchatnov
P R
PR
Liukova
T K
TK
Chugunov
A V
AV
Dugin
S F
SF
Gusev
E I
EI
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000276:immunology*; D002545:Brain Ischemia / Q000276:immunology* / Q000401:mortality / Q000503:physiopathology; D002097:C-Reactive Protein / Q000276:immunology*; D002343:Carotid Artery, Internal / Q000503:physiopathology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000276:immunology*; D009418:S100 Proteins / Q000276:immunology*; D015996:Survival Rate; D016896:Treatment Outcome
D001323:Autoantibodies; D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D002097:C-Reactive Protein; D010751:Phosphopyruvate Hydratase