Relationship between apoptosis and proliferation in secondary tumors of the brain.
A correlation between apoptosis and proliferation in astrocytomas and oligodendrogliomas, but not in glioblastomas, has been previously reported. An index for apoptosis and proliferation was established for each tumor in a series of 20 brain metastases, and its correlation was studied using the Spearman rank correlation test. Apoptosis index (AI) ranged between 1 and 78% (mean SD: 11.48+/-16.4). Proliferation index (PI) ranged between 2.4 and 21% (mean+/-SD: 8.23+/-4.8). When the relationship between AI and PI was studied, a clear correlation was found (r: 0.8965, 95% CI: 0.74-0.95; P < 0.0001). Therefore, it is concluded that a clear correlation exists between proliferation and apoptosis in secondary tumors of the brain.
Vaquero
Jesús
J
Laboratory of Experimental Neuro-Oncology, Mapfre-Medicine Foundation, Spain. jvaqueroc@telefonica.net
Zurita
Mercedes
M
Aguayo
Concepción
C
Coca
Santiago
S
D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000502:physiology*; D001254:Astrocytoma / Q000473:pathology* / Q000556:secondary*; D001932:Brain Neoplasms / Q000473:pathology* / Q000556:secondary*; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000473:pathology* / Q000556:secondary*