title: Vanishing pancreatic grafts.
abstract: Comparison of pancreaticoduodenal transplants (PDT) and duct-ligated pancreas transplant (DLPT) were performed using syngeneic and allogeneic studies in rats. Both DLPT and PDT allogeneic grafts showed mild rejection. DLPT groups showed disorganized pathology and acini replaced by fat. Eventually, massive fibrosis was seen in the Islets of Langerhans, as well as rejection cellular infiltrates. In both PDT groups, normal histology was observed in the same period. Thus the effect of duct occlusion is highly detrimental for the grafts.
authors.affiliation: San Diego Microsurgical Institute, San Diego, CA 92103, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Pivetti
authors.forename: In Chul
authors.initials: IC
authors.lastname: Hong
authors.forename: Chang H
authors.initials: CH
authors.lastname: Yoo
authors.forename: Sun
authors.initials: S
authors.lastname: Lee
authors.forename: Kenny
authors.initials: K
authors.lastname: Kim
authors.forename: Gregory
authors.initials: G
authors.lastname: Emmanuel
authors.forename: Jason
authors.initials: J
authors.lastname: Kim
authors.forename: Romy
authors.initials: R
authors.lastname: Chung
authors.forename: Slawomir
authors.initials: S
authors.lastname: Niewiadomski
authors.forename: Paul
authors.initials: P
authors.lastname: Wolf
authors.forename: R F
authors.initials: RF
authors.lastname: Gittes
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000473:pathology; D008026:Ligation / Q000009:adverse effects; D010179:Pancreas / Q000473:pathology*; D016035:Pancreas Transplantation / Q000009:adverse effects*; D010183:Pancreatic Ducts / Q000601:surgery; D011184:Postoperative Period; D051381:Rats; D011917:Rats, Inbred Lew; D017207:Rats, Sprague-Dawley; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic