title: Estimation of the extent of synteny between Tetraodon nigroviridis and Homo sapiens genomes.
abstract: This paper presents a genomic comparison between 20 sequenced BACs (or fragments of BACs) from Tetraodon nigroviridis and the human genome. A total of 199 fish genes were identified by informatics resources, together with their putative human orthologues. Comparisons of the localizations in both species led to the identification of 32 syntenic regions and a minimum of 131 rearrangements in these regions that occurred during independent evolution of these species. This made it possible to estimate the rate of genomic rearrangements that occurred per million years (and per megabase). This rate is comparable to that obtained by comparison of the Fugu rubripes shotgun sequence data to human data but is significantly higher that those obtained by comparing the human genome to mammalian genomes. Overall, it suggests that genomic evolution by rearrangement is not uniform within the vertebrate group.
authors.affiliation: Genethon, 1 rue de l'Internationale, BP60, 90002 Evry Cedex, France. bernot@genethon.fr
authors.forename: Alain
authors.initials: A
authors.lastname: Bernot
authors.forename: Jean
authors.initials: J
authors.lastname: Weissenbach
mesh_terms: D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics; D016384:Consensus Sequence; D019143:Evolution, Molecular; D015321:Gene Rearrangement; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D026801:Synteny; D023721:Tetraodontiformes / Q000235:genetics*; D013997:Time Factors