[The apolipoprotein E polymorphism in age related macular degeneration].
OBJECTIVE
The aim of the study was to evaluate association of apo E polymorphism with AMD.


METHODS
The included participants of this study were: 45 patients aged 60 to 71 (mean age 66.2 +/- 3.6), treated because of AMD. Genomic DNA was extracted from peripheral blood leukocytes, and the subsequent analysis of apo E genotypes was performed by polymerase chain reaction (PCR).


RESULTS
In our study the allele frequencies in control group of patients weresimilar to the apo E allele distribution presented by other authors in Caucasian populations. We have not found significant differences between AMD and control group patients for apo (E) genotype or allele frequency. Compared with control group (epsilon4 -13.6%, epsilon2 -2.27%), the frequency of epsilon4 allele was not significantly decreased (11.11%) and epsilon2 allele frequency (7.77%) increased in AMD patients.


CONCLUSIONS
The results of our present study have not indicate a significant association between AMD development and apo E allele frequency, in our studied population of AMD patients.
Nowak
Mariusz
M
Zakładu Patofizjologii Katedry Patofizjologii i Endokrynologii Slaskiej Akademii Medycznej.
Swietochowska
Elzbieta
E
Szapska
Bozena
B
Marek
Bogdan
B
Wielkoszyński
Tomasz
T
Kozioł
Henryk
H
Klimek
Joanna
J
Kajdaniuk
Dariusz
D
Kos-Kudła
Beata
B
Ostrowska
Zofia
Z
Karpe
Jacek
J
Głogowska-Szelag
Joanna
J
Siemińska
Lucyna
L
D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E