Immunological advantages of advanced laparoscopy.
Surgical trauma causes significant alterations in host immune function. Compared with open surgery, laparoscopic surgery is associated with reduced postoperative pain and more rapid return to normal activity. Experimental data have also shown more aggressive tumor establishment and growth rates following open surgery and laparoscopic surgery. Surgery-related immunosuppression may be partly responsible for the differences in cancer growth and outcome noted. It is clear that the choice of abdominal surgical approach has immunologic consequences. Further studies are needed to better the time course and extent of surgery-related alterations in the immune system and their clinical importance. A better understanding of the impact of surgery on the immune system may provide opportunities for pharmacologic manipulation of postoperative immune function to improve clinical results.
Sylla
Patricia
P
Department of Surgery, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, NY 10032, USA.
Kirman
Irena
I
Whelan
Richard L
RL
D000005:Abdomen / Q000601:surgery*; D000008:Abdominal Neoplasms / Q000276:immunology / Q000601:surgery; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007107:Immune System / Q000276:immunology / Q000503:physiopathology*; D007111:Immunity, Cellular; D007166:Immunosuppressive Agents / Q000494:pharmacology; D010535:Laparoscopy; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000276:immunology; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology
D007166:Immunosuppressive Agents