title: Quasi-linear viscoelastic properties of fibrotic neck tissues obtained from ultrasound indentation tests in vivo.
abstract: BACKGROUND
  Hand palpation is a conventional way to assess and document soft tissue fibrosis. But it is semi-quantitative and subjective, so there is a need to develop quantitative and objective methods for this purpose.
  
  
  METHODS
  105 patients with different degrees of radiation-induced fibrosis of soft tissue of the neck were assessed using an ultrasound indentation method. The force response was reconstructed from the indentation history using a quasi-linear viscoelastic model with four material parameters. The parameters which best curve-fitted the force response with respect to the experimentally measured one, were selected as the viscoelastic properties of the tested soft tissue. These parameters were compared among patient subgroups with different degrees of fibrosis as scored by hand palpation, and also compared with those of a control group of healthy, non-irradiated subjects. Their relation to the rotation range of the neck and the effective Young's modulus, were also assessed.
  
  
  RESULTS
  Soft tissue with a more severe degree of fibrosis was associated with a larger initial stiffness and a more rapid increase in stiffness under loading. Viscoelasticity parameters could discriminate soft tissue with different degrees of clinical fibrosis and had significant correlation with clinical parameters of fibrosis.
  
  
  CONCLUSIONS
  Change of viscoelastic properties is reflection of pathological modifications of components in fibrotic soft tissues. Measurement of viscoelasticity parameters of soft tissue provides a quantitative and objective approach for the researcher and clinician to quantify soft tissue fibrosis.
  
  
  CONCLUSIONS
  Measurement of the change of viscoelastic properties of soft tissue provides a quantitative and objective approach for researchers and clinicians to quantify soft tissue fibrosis which is one of the most common late effects of radiotherapy.
authors.affiliation: Rehabilitation Engineering Center, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Huang
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Zheng
authors.forename: Sing-Fai
authors.initials: SF
authors.lastname: Leung
mesh_terms: D000328:Adult; D004548:Elasticity; D005355:Fibrosis; D006244:Hardness; D006245:Hardness Tests / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016014:Linear Models; D008954:Models, Biological; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy; D009333:Neck / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology* / Q000528:radiation effects*; D010173:Palpation; D011832:Radiation Injuries / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D017695:Soft Tissue Injuries / Q000000981:diagnostic imaging / Q000503:physiopathology; D014463:Ultrasonography; D014783:Viscosity