Synthesis of 2,3-disubstituted indole on solid phase by the Fischer indole synthesis.
2,3-Disubstituted indoles were synthesized by solid-phase reaction using the Fischer indole synthesis. A "traceless" silicon linker was employed with the silicon-carbon bonding being cleaved with TFA. An oxygen atom was placed into the middle of the spacer/linker so as to enhance solid-phase synthesis by better solvation.
Mun
Han-Seo
HS
College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea.
Ham
Won-Hun
WH
Jeong
Jin-Hyun
JH
D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
D007211:Indoles