title: Slit-lamp needle revision of failed filtering blebs using high-dose mitomycin C.
abstract: OBJECTIVE
  To investigate the efficacy of bleb needle revision with high-dose mitomycin C in reviving failed filtering blebs after 1 year.
  
  
  METHODS
  We reviewed the charts of 44 patients with one eye that had undergone bleb needle revision with a mixture of 0.1 mL of mitomycin (0.4 mg/mL) mixed with 0.1 mL of non-preserved 1% lidocaine. At least 12 months of follow-up were required. A successful bleb needle revision was defined as one that did not require a subsequent needling, glaucoma surgery, or medication to reach an intraocular pressure (IOP) greater than 4 mm Hg but less than 22 mm Hg. A qualified success was defined as a successful bleb needle revision that required subsequent needling or medication.
  
  
  RESULTS
  The bleb needle revision with high-dose mitomycin was a success or qualified success after 12 months in 28 patients or 64% (95% confidence interval, 50% to 78%). The baseline IOP in these patients was 26.7 +/- 8.2 mm Hg (range 15 to 48 mm Hg) using an average of 1.5 +/- 1.5 glaucoma medications. The IOP after 1 year was 13.6 +/- 4.0 (range 6 to 21 mm Hg) with an average of 0.5 +/- 0.8 medications. Of 44 patients, 17 (39%) were successes and 11 (25%) were qualified successes.
  
  
  CONCLUSIONS
  Bleb needle revision with high-dose MMC was effective in reducing the IOP in 64% of eyes with a failed filtering bleb with minimal long-term complications.
authors.affiliation: Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA. shetty.rajesh@mayo.edu
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Shetty
authors.forename: Leah
authors.initials: L
authors.lastname: Wartluft
authors.forename: Marlene R
authors.initials: MR
authors.lastname: Moster
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003228:Conjunctiva / Q000187:drug effects* / Q000473:pathology / Q000601:surgery*; D005260:Female; D005355:Fibrosis; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D009339:Needles; D010030:Ostomy / Q000379:methods*; D012086:Reoperation; D012189:Retrospective Studies; D012590:Sclera / Q000187:drug effects / Q000601:surgery; D014130:Trabeculectomy; D017211:Treatment Failure
chemical_list: D000964:Antimetabolites, Antineoplastic; D016685:Mitomycin