The Janus face of cyclooxygenase-2 in ischemic stroke: shifting toward downstream targets.
Iadecola
Costantino
C
Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 411 E 69th St, KB410, New York, NY 10021, USA. coi2001@med.cornell.edu
Gorelick
Philip B
PB
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002545:Brain Ischemia / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects* / Q000494:pharmacology*; D006801:Humans; D007511:Ischemia / Q000473:pathology*; D008954:Models, Biological; D011453:Prostaglandins / Q000378:metabolism; D020521:Stroke / Q000378:metabolism / Q000473:pathology*
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D016718:Arachidonic Acid; D051546:Cyclooxygenase 2