Gas chromatography-mass spectrometry analysis of trifluoroacetyl derivatives of precursors of nitrogen and sulfur mustards for verification of chemical weapons convention.
Trifluoroacetylation reactions were optimized for gas chromatography-mass spectrometric (GC-MS) analysis of precursors of nitrogen and sulfur mustards using newly developed N-trifluoroacetylbenzimidazole (TFABI) and known N-trifluoroacetylimidazole (TFAI) and N-trifluoroacetylbenzotriazole (TFABT) reagents. TFAI and TFABI gave the best results in terms of yields and reaction time. Trifluoroacetyl derivatives showed clean total ion chromatograms in GC-MS analysis than trimethylsilyl (TMS) derivatives. The negative ion chemical ionization analysis of these derivatives gave pseudo molecular weight information, with low limit of detection.
Pardasani
Deepak
D
Vertox Laboratory, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India.
Palit
Meehir
M
Gupta
A K
AK
Kanaujia
Pankaj K
PK
Dubey
D K
DK
D002618:Chemical Warfare; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D008466:Mechlorethamine / Q000737:chemistry*; D009151:Mustard Gas / Q000737:chemistry*
D008466:Mechlorethamine; D009151:Mustard Gas