Decreased lateral geniculate nucleus activation in retrogeniculate hemianopia demonstrated by functional magnetic resonance imaging at 4 Tesla.
Functional magnetic resonance imaging (fMRI) can detect lateral geniculate nucleus (LGN) activation. We studied LGN function in 5 patients with retrogeniculate homonymous hemianopia using fMRI at 4.0 Tesla during binocular visual stimulation. Decreased activation of visual cortex and LGN on the side of the lesion was observed in all 5 patients. These findings suggest that retrogeniculate lesions are associated with decreased activation of the LGN, due to retrograde degeneration or a functional decrease caused by decreased feedback from ipsilateral visual cortex.
Miki
Atsushi
A
Functional MRI Research Unit of the Children's Hospital of Philadelphia, and Department of Neurology, Division of Neuro-Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Liu
Grant T
GT
Modestino
Edward J
EJ
Bonhomme
Gabrielle R
GR
Liu
Chia-Shang J
CS
Haselgrove
John C
JC
D000293:Adolescent; D000328:Adult; D005260:Female; D005829:Geniculate Bodies / Q000503:physiopathology*; D006423:Hemianopsia / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015348:Vision, Binocular / Q000502:physiology; D014793:Visual Cortex / Q000503:physiopathology*; D014795:Visual Pathways / Q000503:physiopathology