title: Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry.
abstract: OBJECTIVE
  To determine the characteristics of inflammatory bowel disease (IBD) in young patients.
  
  
  METHODS
  Uniform data were collected from a cohort of patients with IBD who were enrolled from January 2000 to November 2002 at six pediatric centers (Pediatric IBD Consortium).
  
  
  RESULTS
  Of 1370 children in the registry, the mean age at IBD diagnosis was 10.3 +/- 4.4 years; 54% were male, and 86% were white. Diagnosis was confirmed in 87 (6.1%) under 3 years of age, 211 (15.4%) before 6 years, 654 (47.7%) at 6 to 12 years, and 505 (36.9%) at 13 to 17 years. More than 63% of children younger than 8 years of age had isolated colonic disease, whether Crohn disease, ulcerative colitis (UC), or indeterminate colitis. Conversely, only 35% of those 8 years of age or older had isolated colonic disease ( P < .0001). Overall, 29% had one or more family members with IBD. The subgroup of children younger than 3 years of age with UC had the highest prevalence of first-degree relatives with IBD (44%).
  
  
  CONCLUSIONS
  This demographically diverse pediatric IBD cohort revealed age-related variation in the distribution of IBD phenotype, with a high prevalence of isolated colonic disease in young children. Positive family history was especially common in young patients with UC.
authors.affiliation: UCSF Children's Hospital, University of California, San Francisco, CA 94143, USA. mheyman@peds.ucsf.edu
authors.forename: Melvin B
authors.initials: MB
authors.lastname: Heyman
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Kirschner
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Gold
authors.forename: George
authors.initials: G
authors.lastname: Ferry
authors.forename: Robert
authors.initials: R
authors.lastname: Baldassano
authors.forename: Stanley A
authors.initials: SA
authors.lastname: Cohen
authors.forename: Harland S
authors.initials: HS
authors.lastname: Winter
authors.forename: Patricia
authors.initials: P
authors.lastname: Fain
authors.forename: Chris
authors.initials: C
authors.lastname: King
authors.forename: Terry
authors.initials: T
authors.lastname: Smith
authors.forename: Hashem B
authors.initials: HB
authors.lastname: El-Serag
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D003710:Demography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012042:Registries / Q000706:statistics & numerical data; D014481:United States / Q000453:epidemiology