Detection of herpesvirus-6A in a case of subacute cerebellitis and myoclonic dystonia.
This is a case study of a child who developed roseola infantum first, then varicella, and was later affected by acute cerebellar syndrome, severe truncal ataxia, and myoclonic dystonia. Human herpesvirus 6 (HHV-6) A and B were detected in the cerebrospinal fluid (CSF) and peripheral blood, respectively, upon ataxia onset. The intricacy of this case suggests multifaceted conclusions ranging from the need for a multidirectional approach to neurological diseases, to confirmation of a more pronounced neurotropism of HHV-6A and a possible role of viruses in myoclonic dystonia syndrome, although this last hypothesis should be confirmed by larger studies.
Borghi
Elisa
E
Department of Biomedical Science and Technology, University of Milan, Milan, Italy.
Pagani
Elisabetta
E
Mancuso
Roberta
R
Delbue
Serena
S
Valli
Marilena
M
Mazziotti
Romina
R
Giordano
Lucio
L
Micheli
Roberto
R
Ferrante
Pasquale
P
D002526:Cerebellar Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000821:virology*; D002644:Chickenpox / Q000150:complications / Q000821:virology; D002675:Child, Preschool; D004421:Dystonia / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications / Q000821:virology*; D005077:Exanthema Subitum / Q000150:complications / Q000821:virology; D005260:Female; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D009207:Myoclonus / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications / Q000821:virology*; D019349:Roseolovirus Infections / Q000150:complications / Q000821:virology