title: A case of Wegener's granulomatosis with pulmonary bleeding successfully treated with double filtration plasmapheresis (DFPP).
abstract: We report a case of a 41-year-old Japanese man who presented with rapidly progressive glomerulonephritis, chronic sinusitis, and positive cytoplasmic-antineutrophil cytoplasmic antibody (c-ANCA). Renal biopsy showed crescentic glomerulonephritis, and he was diagnosed as having Wegener's granulomatosis. During the clinical course, he suffered from pulmonary bleeding, and combination therapy of steroid, immunosuppressant, and double filtration plasmapheresis (DFPP) was started. He rapidly entered remission after assistance through DFPP, suggesting the potential efficacy of DFPP for Wegener's granulomatosis, especially with pulmonary bleeding.
authors.affiliation: Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine (A8), 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. iwatani@medone.med.osaka-u.ac.jp
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Iwatani
authors.forename: Takashi
authors.initials: T
authors.lastname: Uzu
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kakihara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Keizo
authors.initials: K
authors.lastname: Kanasaki
authors.forename: Masaya
authors.initials: M
authors.lastname: Yamato
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hirai
authors.forename: Koichi
authors.initials: K
authors.lastname: Umimoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamauchi
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008168:Lung / Q000098:blood supply / Q000473:pathology*; D008297:Male; D015523:Maxillary Sinusitis / Q000209:etiology / Q000473:pathology; D010956:Plasmapheresis; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D019268:Antibodies, Antineutrophil Cytoplasmic; D011239:Prednisolone