title: Antimicrobial and radical scavenging flavonoids from the stem wood of Erythrina latissima.
abstract: From the stem wood of Erythrina latissima, two isoflavones and a flavanone were isolated and characterized as 7,3'-dihydroxy-4'-methoxy-5'-(gamma,gamma-dimethylallyl)isoflavone (erylatissin A), 7,3'-dihydroxy-6'',6''-dimethyl-4'',5''-dehydropyrano [2'',3'': 4',5']isoflavone (erylatissin B), (-)-7,3'-dihydroxy-4'-methoxy-5'-(gamma,gamma-dimethylallyl)flavanone (erylatissin C), respectively, in addition to 10 known flavonoids. Structures of these compounds were determined on the basis of their spectroscopic data. These compounds showed antimicrobial activity against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida mycoderma. The isolated compounds also exhibited weak radical scavenging properties towards DPPH radical.
authors.affiliation: Department of Chemistry, University of Botswana, Private Bag UB 00704, Gaborone, Botswana.
authors.forename: Musa
authors.initials: M
authors.lastname: Chacha
authors.forename: Gomotsang
authors.initials: G
authors.lastname: Bojase-Moleta
authors.forename: Runner R T
authors.initials: RR
authors.lastname: Majinda
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification; D001713:Biphenyl Compounds; D004895:Erythrina / Q000737:chemistry*; D044950:Flavanones / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification; D007529:Isoflavones / Q000737:chemistry; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry*; D014934:Wood
chemical_list: C498108:7,3'-dihydroxy-4'-methoxy-5'-(gamma,gamma-dimethylallyl)flavanone; C498105:7,3'-dihydroxy-4'-methoxy-5'-(gamma,gamma-dimethylallyl)isoflavone; C498107:7,3'-dihydroxy-6'',6''-dimethyl-4'',5''-dehydropyrano(2'',3'': 4',5')isoflavone; D000890:Anti-Infective Agents; D001713:Biphenyl Compounds; D044950:Flavanones; D005419:Flavonoids; D016166:Free Radical Scavengers; D007529:Isoflavones; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl