Engulfment: ingestion and migration with Rac, Rho and TRIO.
Apoptotic cells are removed from tissues by uptake mechanisms that depend on the GTPase Rac (CED-10 in C. elegans), which is activated by DOCK180/CED-5 in a trimolecular complex with ELMO/CED-12 and CrkII/CED-2. A study now identifies upstream components of this pathway in both worms and mammalian cells involving yet another GTPase, RhoG/MIG-2, and its activator TRIO/UNC-73.
Henson
Peter M
PM
National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. hensonp@njc.org
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology*; D008322:Mammals / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000502:physiology*; D010587:Phagocytosis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D020744:rac GTP-Binding Proteins / Q000502:physiology*
C407268:CED-10 protein, C elegans; C111579:CED-5 protein, C elegans; D029742:Caenorhabditis elegans Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C111263:UNC-73 protein, C elegans; C442327:Mig-2 protein, C elegans; D020744:rac GTP-Binding Proteins