Behavioral toxicity of acute and subacute exposure to triethyltin in the rat.
The behavioral effects of both acute and subacute triethyltin (TET) exposure were examined in the rat. Animals acutely exposed to TET at doses of 0, 1.5 and 3.0 mg/kg showed a dose-related decrease in motor activity when tested between 2 and 4 hr following exposure. Subacute (3 week) exposure to TET in the drinking water (5 or 10 ppm) resulted in performance decrements in the following: maze activity, open field behavior, acoustic startle response and landing foot-spread. Early signs of behavioral deficits were observed 2 weeks after 10 ppm TET. These effects were reversible within one month after termination of exposure.
Reiter
L
L
Neurotoxicology Division, Health Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Kidd
K
K
Heavner
G
G
Ruppert
P
P
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D020258:Neurotoxicity Syndromes / Q000523:psychology*; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects; D014267:Triethyltin Compounds / Q000633:toxicity*
D014267:Triethyltin Compounds; C031575:triethyltin