title: Prevalence and risk factors for prolonged QTc in a multiethnic cohort in rural Hawaii.
abstract: BACKGROUND
  Few studies have examined the biochemical risk factors for prolonged QTc, a predictor of mortality in numerous studies. We report on the prevalence and risk factors for prolonged QTc in a multiethnic population in rural Hawaii.
  
  
  METHODS
  Electrocardiograms were collected from 1415 participants in a cross-sectional survey. The QT interval lengths were corrected for heart rate using Bazett's formula. Linear and logistic regression models were used to examine associations between various cardiovascular risk factors with QTc.
  
  
  RESULTS
  Among the CVD risk factors examined, only age, gender, 2-h glucose, and systolic blood pressure (SBP) were independently associated with QTc interval length. Significant ethnic differences in prevalence were also observed, which persisted after controlling for other risk factors.
  
  
  CONCLUSIONS
  Significant associations between prolonged QTc and ethnic ancestry, but not cholesterol or triglyceride levels, suggest that genetic factors may play a more important role in determining QTc interval length than conventional biochemical and metabolic CVD risk factors.
authors.affiliation: University of Hawaii at Manoa, Pacific Biomedical Research Center, 1993 East-West Road, Honolulu, Honolulu, HI 96822, USA. andrew@pbrc.hawaii.edu
authors.forename: Andrew
authors.initials: A
authors.lastname: Grandinetti
authors.forename: Steven
authors.initials: S
authors.lastname: Seifried
authors.forename: Joanne
authors.initials: J
authors.lastname: Mor
authors.forename: Healani K
authors.initials: HK
authors.lastname: Chang
authors.forename: André G
authors.initials: AG
authors.lastname: Theriault
mesh_terms: D000328:Adult; D000367:Age Factors; D001786:Blood Glucose; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000208:ethnology / Q000401:mortality; D003430:Cross-Sectional Studies; D004562:Electrocardiography; D005006:Ethnicity / Q000235:genetics; D005260:Female; D006254:Hawaii / Q000453:epidemiology / Q000208:ethnology; D006801:Humans; D008133:Long QT Syndrome / Q000453:epidemiology* / Q000208:ethnology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors; D012424:Rural Population; D012737:Sex Factors
chemical_list: D001786:Blood Glucose