A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3.
A consanguineous family with autosomal recessive nonsyndromic hearing impairment (NSHI) was ascertained in Pakistan and displayed significant evidence of linkage to 3q13.31-q22.3. The novel locus (DFNB42) segregating in this kindred, maps to a 21.6 cM region according to a genetic map constructed using data from both the deCode and Marshfield genetic maps. This region of homozygosity is flanked by markers D3S1278 and D3S2453. A maximum multipoint LOD score of 3.72 was obtained at marker D3S4523. DFNB42 represents the third autosomal recessive NSHI locus to map to chromosome 3.
Aslam
Muhammad
M
Department of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan.
Wajid
Muhammad
M
Chahrour
Maria H
MH
Ansar
Muhammad
M
Haque
Sayedul
S
Pham
Thanh L
TL
Santos
Regie P
RP
Yan
Kai
K
Ahmad
Wasim
W
Leal
Suzanne M
SM
D001299:Audiometry; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D034381:Hearing Loss / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree