title: Comparison of ventricular long-axis function in patients with cardiac amyloidosis versus idiopathic restrictive cardiomyopathy.
abstract: To investigate ventricular long-axis function in cardiac amyloidosis (CA) and idiopathic restrictive cardiomyopathy (IRC), 16 patients with CA and 14 with IRC were studied. Left ventricular (LV) long-axis function was depressed in all patients with CA compared with only 36% of patients with IRC. Impairment in longitudinal function was clearly evident, even if fractional shortening and LV filling were normal. Ventricular long-axis function may be used as a sensitive marker of early systolic dysfunction. CA and IRC have quite distinct pathophysiologic profiles, raising some concerns about the appropriateness of considering them as 2 subtypes of a single nosographic entity.
authors.affiliation: The Royal Brompton Hospital, London, United Kingdom. e_perugini@hotmail.com <e_perugini@hotmail.com>
authors.forename: Enrica
authors.initials: E
authors.lastname: Perugini
authors.forename: Claudio
authors.initials: C
authors.lastname: Rapezzi
authors.forename: Letizia Bacchi
authors.initials: LB
authors.lastname: Reggiani
authors.forename: Philip
authors.initials: P
authors.lastname: Poole-Wilson
authors.forename: Angelo
authors.initials: A
authors.lastname: Branzi
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Henein
mesh_terms: D000686:Amyloidosis / Q000150:complications / Q000503:physiopathology*; D009202:Cardiomyopathies / Q000150:complications / Q000503:physiopathology*; D002313:Cardiomyopathy, Restrictive / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D016277:Ventricular Function, Left