"Molecular chameleons". Design and synthesis of C-4-substituted imidazole fleximers.
The synthesis of two flexible nucleosides is presented. The "fleximers" feature the purine ring system split into its imidazole and pyrimidine components. This modification serves to introduce flexibility to the nucleoside while still retaining the elements essential for molecular recognition. As a result, these structurally innovative nucleosides can more readily adapt to capricious binding sites and, as such, should find use for investigating enzyme-coenzyme as well as nucleic acid-protein interactions.
Seley
Katherine L
KL
Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA. kseley@umbc.edu
Salim
Samer
S
Zhang
Liang
L
D007093:Imidazoles / Q000138:chemical synthesis*; D009705:Nucleosides / Q000138:chemical synthesis*
D007093:Imidazoles; D009705:Nucleosides