[The adverse reactions of parenteral norvancomycin in 1031 patients].
OBJECTIVE
To investigate the safety of norvancomycin, and provide basis for its rational use in clinical practice.


METHODS
We documented all adverse events occurred in inpatients who receive intravenous infusion of norvancomycin, then we evaluated the relationship between adverse events and norvancomycin and calculated the rates of adverse reaction.


RESULTS
1031 patients were enrolled in this study from March 2002 to June 2003 and 965 of them could be evaluated. 80 adverse reactions occurred in 965 patients who received norvancomycin, giving a total adverse reaction rate of 8.29%. The systemic adverse reactions included renal impairment (4.04%), hepatic impairment (2.38%) and allergic reaction (1.76%). 15 patients discontinued the treatment because of the adverse reaction. The rates were higher in patients who use other antimicrobial agents concomitantly or whose age >/= 60 years. The rates of renal impairment were higher in those with age >/= 60 years, and the rates of hepatic impairment were higher in whose received this agent longer than 14 days. These factors were independent risk factors (P < 0.05).


CONCLUSIONS
The overall adverse reaction rate of norvancomycin was low. A few patients experienced drug-related reaction, most of these adverse reactions were mild and tolerable. The adverse reactions tended to occur in older patients, those who use other antibiotic concomitantly or those who receive this agent longer than 14 days.
Liu
Yang
Y
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China. liuyang@fudan.edu.cn
Wu
Ju-Fang
JF
Xiao
Zheng-Lun
ZL
Sheng
Rui-Yuan
RY
Lü
Xiao-Ju
XJ
Chen
Yan
Y
Zhang
Ying-Yuan
YY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001424:Bacterial Infections / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D014640:Vancomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
D000900:Anti-Bacterial Agents; D014640:Vancomycin; C511195:norvancomycin