Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties.
Functionalized cationic carbon nanotubes are able to form a stable complex with CpG ODN based on charge interaction and to increase the immunostimulatory activity of CpG motifs.
Bianco
Alberto
A
Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France. A.Bianco@ibmc.u-strasbg.fr
Hoebeke
Johan
J
Godefroy
Sylvie
S
Chaloin
Olivier
O
Pantarotto
Davide
D
Briand
Jean-Paul
JP
Muller
Sylviane
S
Prato
Maurizio
M
Partidos
Charalambos D
CD
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000737:chemistry*; D000818:Animals; D002412:Cations; D018899:CpG Islands / Q000276:immunology*; D007371:Interferon-gamma / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D007700:Kinetics; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D051379:Mice; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009841:Oligonucleotides / Q000008:administration & dosage / Q000737:chemistry* / Q000276:immunology*; D020349:Surface Plasmon Resonance
D000276:Adjuvants, Immunologic; D002412:Cations; D015850:Interleukin-6; D037742:Nanotubes, Carbon; D009841:Oligonucleotides; D007371:Interferon-gamma