Association of R602W in a protein tyrosine phosphatase gene with a high risk of rheumatoid arthritis in a British population: evidence for an early onset/disease severity effect.
Steer
Sophia
S
Guy's, King's and St Thomas' School of Medicine, London, UK.
Lad
Bhaneeta
B
Grumley
Janet A
JA
Kingsley
Gabrielle H
GH
Fisher
Sheila A
SA
D000328:Adult; D017668:Age of Onset; D001120:Arginine; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics*; D004739:England; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D020641:Polymorphism, Single Nucleotide; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D012720:Severity of Illness Index; D014364:Tryptophan; D044465:White People / Q000235:genetics*
D014364:Tryptophan; D001120:Arginine; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22; D017027:Protein Tyrosine Phosphatases