title: Arterial thrombosis in four patients treated with thalidomide.
abstract: Thalidomide has been associated with venous thrombotic events, as reported in the post-marketing surveillance reports by Celgene Corporation; as well as case reports in the literature. Seven arterial thrombotic events have been reported in patients receiving thalidomide with 3 cases occurring in patients with other predisposing conditions. We report 4 additional cases of arterial thromboses in 1 lymphoma and 3 myeloma patients treated with thalidomide. The mechanism for these events is unclear; however, it is significant that 2 patients were receiving concomitant anticoagulation with aspirin and warfarin.
authors.affiliation: Albany College of Pharmacy, NY 12208, USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Scarpace
authors.forename: Theresa
authors.initials: T
authors.lastname: Hahn
authors.forename: Hilary
authors.initials: H
authors.lastname: Roy
authors.forename: Karen
authors.initials: K
authors.lastname: Brown
authors.forename: Pamela
authors.initials: P
authors.lastname: Paplham
authors.forename: Asher
authors.initials: A
authors.lastname: Chanan-Khan
authors.forename: Koen
authors.initials: K
authors.lastname: van Besien
authors.forename: Philip L
authors.initials: PL
authors.lastname: McCarthy
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases; D001241:Aspirin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000139:chemically induced; D008223:Lymphoma / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy; D013792:Thalidomide / Q000009:adverse effects* / Q000627:therapeutic use; D013927:Thrombosis / Q000139:chemically induced*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D013792:Thalidomide; D014859:Warfarin; D001241:Aspirin