[Occurrence of Helicobacter pylori specific antigens in diseases of gastrointestinal tract].
The results of the immunophoretic analysis of H. pylori antigenic structure are presented. Along with H. pylori O-antigen, specific surface antigen of acidic nature, relatively thermolabile with characteristics similar to those of K-antigens, was detected. A diagnosticum based on the coagglutination test for the rapid detection of H. pylori specific antigens in the patients' biological fluids (coprofiltrate, saliva) by the noninvasive method was developed. The circulation mode of H. pylori in human body and its correlation with the clinical symptoms of the disease was shown. H. pylori antigens were very frequently detected (in 65 - 83% of cases) in patients with acute bacterial enteric infections: shigellosis, salmonellosis, yersiniosis, campylobacteriosis. The newly developed method seems to be promising for the rapid diagnosis of H. pylori associated infections, for the prolonged monitoring and evaluation of the effectiveness of antibacterial therapy.
Belaia
Iu A
IuA
Vakhrameeva
M S
MS
Petrukhin
V G
VG
Bondarenko
V M
VM
Belaia
O F
OF
Evdokimov
V V
VV
Kurmanova
D M
DM
Iudina
T I
TI
Nesterenko
V G
VG
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000942:Antigens, Bacterial / Q000032:analysis*; D002648:Child; D003937:Diagnosis, Differential; D005243:Feces / Q000382:microbiology; D005260:Female; D005759:Gastroenteritis / Q000175:diagnosis*; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000382:microbiology; D012680:Sensitivity and Specificity
D000942:Antigens, Bacterial