Analyzing the biology on the system level.
Although various genome projects have provided us enormous static sequence information, understanding of the sophisticated biology continues to require integrating the computational modeling, system analysis, technology development for experiments, and quantitative experiments all together to analyze the biology architecture on various levels, which is just the origin of systems biology subject. This review discusses the object, its characteristics, and research attentions in systems biology, and summarizes the analysis methods, experimental technologies, research developments, and so on in the four key fields of systems biology--systemic structures, dynamics, control methods, and design principles.
Tong
Wei
W
Beijing Genomics Institute, Beijing 101300, China. tongw@genomics.org.cn
D005075:Biological Evolution; D015870:Gene Expression; D023281:Genomics / Q000379:methods*; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods* / Q000639:trends