Antioxidative catechol lignans converted from sesamin and sesaminol triglucoside by culturing with Aspergillus.
Sesamin and sesaminol triglucoside in sesame seeds are major lignans that display an abundance of biological activities. Although their antioxidative activity in vitro is weak, they have been reported to suppress oxidative stress in vivo. We investigated the production of new antioxidative lignans from sesame lignans by culturing with the genus Aspergillus to enhance the function of food materials. Media containing sesamin or sesaminol triglucoside increased antioxidative activity for DPPH radical scavenging by culturing with Aspergillus usamii mut. shirousamii RIB2503. The antioxidative lignans in sesamin medium were identified as sesamin 2,6-dicatechol and episesamin 2,6-dicatechol. Those in sesaminol triglucoside medium were identified as sesaminol 6-catechol and episesaminol 6-catechol, which are novel antioxidative lignans. It is suggested that they may exhibit higher antioxidative activity than sesamin and sesaminol triglucoside because they have the catechol functional moiety.
Miyake
Yoshiaki
Y
Faculty of Human Wellness, Tokaigakuen University, Nagoya 468-8514, Japan. miyakeyo@tokaigakuen-c.ac.jp
Fukumoto
Syuichi
S
Okada
Miki
M
Sakaida
Kazuhiro
K
Nakamura
Yoshimasa
Y
Osawa
Toshihiko
T
D000975:Antioxidants / Q000378:metabolism*; D001230:Aspergillus / Q000378:metabolism*; D002396:Catechols / Q000378:metabolism*; D004149:Dioxoles / Q000378:metabolism*; D005663:Furans / Q000378:metabolism*; D005960:Glucosides / Q000378:metabolism; D017705:Lignans / Q000378:metabolism*
D000975:Antioxidants; D002396:Catechols; D004149:Dioxoles; D005663:Furans; D005960:Glucosides; D017705:Lignans; C066016:sesaminol; C054125:sesamin