Clonal spread of a Clostridium difficile strain with a complete set of toxin A, toxin B, and binary toxin genes among Polish patients with Clostridium difficile-associated diarrhea.
Clinically relevant Clostridium difficile strains usually produce toxins A and B. Some C. difficile strains can produce an additional binary toxin. We report clonality among five strains carrying all toxin genes from Polish patients with C. difficile-associated diarrhea. In another strain, possible recombination between binary toxin genes is documented.
Pituch
Hanna
H
Department of Medical Microbiology, The Medical University of Warsaw, 5 Chalubinski Street, 02-004 Warsaw, Poland. hanna.pituch@ib.amwaw.edu.pl
Kreft
Deborah
D
Obuch-Woszczatynski
Piotr
P
Wultańska
Dorota
D
Meisel-Mikołajczyk
Felicja
F
Łuczak
Mirosław
M
van Belkum
Alex
A
D000293:Adolescent; D000328:Adult; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D001427:Bacterial Toxins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D016360:Clostridioides difficile / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D003967:Diarrhea / Q000453:epidemiology* / Q000382:microbiology; D004761:Enterocolitis, Pseudomembranous / Q000453:epidemiology / Q000382:microbiology; D004768:Enterotoxins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014644:Genetic Variation; D006801:Humans; D008969:Molecular Sequence Data; D011044:Poland / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D021521:Ribotyping
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; C041348:tcdA protein, Clostridium difficile; C031815:toxB protein, Clostridium difficile