title: [Associated genes for dementia of the Alzheimer type].
abstract: Dementia of the Alzheimer type (AD) is the leading cause of dementias for the elders. It is a progressively neurodegenerative disorder characterized by global cognitive decline. While most of the rare early-onset AD can be explained by mutations in APP gene and presenilin genes,the genetic etiology of the more common late-onset AD is only partly explained by the APOE-epsilon4 genotype. But the APOE-epsilon4 allele is neither necessary nor sufficient to cause disease and it can only account for less than one-half of the genetic variance of AD. Thus, more genes involved in AD are our special attention.
authors.affiliation: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Ze
authors.initials: Z
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Jin