A diketopiperazine dimer from a marine-derived isolate of Aspergillus niger.
The new diketopiperazine dimer 1, as well as the known compounds TMC-256A1 (2), TMC-256C1 (3), and demethylkotanin (4), were isolated from a culture of Aspergillus niger. The gross structure of 1 was determined by 2D NMR studies and comparison with literature data, and the absolute stereochemistry was elucidated by chiral HPLC analysis of the hydrolysis products.
Ovenden
Simon P B
SP
Cerylid Biosciences, 576 Swan Street, Richmond, Victoria, 3121, Australia.
Sberna
Gian
G
Tait
R Murray
RM
Wildman
Howard G
HG
Patel
Rupal
R
Li
Bin
B
Steffy
Kevin
K
Nguyen
Natalie
N
Meurer-Grimes
Barbara M
BM
D001234:Aspergillus niger / Q000737:chemistry*; D001315:Australia; D002851:Chromatography, High Pressure Liquid; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification; D054659:Diketopiperazines; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010879:Piperazines / Q000737:chemistry* / Q000302:isolation & purification
D002867:Chromones; D003374:Coumarins; D054659:Diketopiperazines; D010879:Piperazines; C467209:TMC 256A1; C467210:TMC 256C1; C497294:demethylkotanin