title: Tilt table design for rapid and sinusoidal posture change with minimal vestibular stimulation.
abstract: BACKGROUND
  Cardiovascular response to fast posture change can be used to model individual orthostatic response under normal circumstances and after spaceflight. We set out to construct a computer-controlled tilt table suitable for repeated sinusoidal tilt motion as well as fast, single head-up tilt (HUT). The movement profile of the table was designed to prevent muscle tensing and limit vestibular stimulation.
  
  
  METHODS
  On the new table, 20 healthy subjects underwent a protocol of fast HUT and sinusoidal tilt motion at 2.5 tilts per minute. BP was measured non-invasively (Finapres). Time domain dynamic response to HUT and frequency domain response to sinusoidal tilts were derived from the beat-to-beat BP and from interbeat-interval (IBI) series.
  
  
  RESULTS
  Tilt motion did not induce dizziness and was experienced by all subjects as smooth. The systolic BP response to fast HUT correlated mildly with the systolic BP spectral power at the sinusoidal tilt frequency (R = 0.47). The IBI response to fast HUT correlated well with the IBI power at the sinusoidal tilt frequency (R = 0.74).
  
  
  CONCLUSIONS
  In this study we presented a computer controlled tilt table capable of fast posture change and sinusoidal tilts. An exploratory protocol demonstrated that the table is suitable for obtaining cardiovascular response to posture change for modeling purposes.
authors.affiliation: Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. j.gisolf@amc.uva.nl
authors.forename: Janneke
authors.initials: J
authors.lastname: Gisolf
authors.forename: Erik M
authors.initials: EM
authors.lastname: Akkerman
authors.forename: A Wim
authors.initials: AW
authors.lastname: Schreurs
authors.forename: Jan
authors.initials: J
authors.lastname: Strackee
authors.forename: Wim J
authors.initials: WJ
authors.lastname: Stok
authors.forename: John M
authors.initials: JM
authors.lastname: Karemaker
mesh_terms: D000328:Adult; D001331:Automation; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011187:Posture; D012984:Software; D013026:Space Flight; D018667:Tilt-Table Test / Q000379:methods*; D013997:Time Factors