Fluvastatin and bisoprolol for the reduction of perioperative cardiac mortality and morbidity in high-risk patients undergoing non-cardiac surgery: rationale and design of the DECREASE-IV study.
Schouten
Olaf
O
Department of Surgery, Erasmus MC, Rotterdam, The Netherlands.
Poldermans
Don
D
Visser
Loes
L
Kertai
Miklos D
MD
Klein
Jan
J
van Urk
Hero
H
Simoons
Maarten L
ML
van de Ven
Louis L
LL
Vermeulen
Maarten
M
Bax
Jeroen J
JJ
Lameris
Thomas W
TW
Boersma
Eric
E
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D017298:Bisoprolol / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000401:mortality* / Q000517:prevention & control; D004359:Drug Therapy, Combination; D017558:Elective Surgical Procedures / Q000401:mortality*; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use*; D000077340:Fluvastatin; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D015994:Incidence; D007211:Indoles / Q000627:therapeutic use*; D007431:Intraoperative Complications / Q000401:mortality / Q000517:prevention & control; D009203:Myocardial Infarction / Q000453:epidemiology / Q000517:prevention & control; D019990:Perioperative Care; D011183:Postoperative Complications / Q000401:mortality / Q000517:prevention & control*; D011292:Premedication; D016016:Proportional Hazards Models; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D018570:Risk Assessment
D000319:Adrenergic beta-Antagonists; D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D000077340:Fluvastatin; D017298:Bisoprolol