title: Sedation for paediatric stereotactic radiosurgery: the dexmedetomidine experience.
abstract: Dexmedetomidine is a potent alpha2 adrenergic agonist, with sedative and analgesic properties which may make it a suitable sedative agent for procedures on paediatric patients. A six-year-old boy required sedation for stereotactic radiosurgical ablation of an arteriovenous malformation on two occasions. Sedation with dexmedetomidine was planned, with increased dosage used on the second occasion. On both occasions dexmedetomidine was inadequate as a sole agent and required supplementation with other agents.
authors.affiliation: Division of Paediatric Anesthesia, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Fahy
authors.forename: M
authors.initials: M
authors.lastname: Okumura
mesh_terms: D000762:Anesthesia Recovery Period; D001165:Arteriovenous Malformations / Q000175:diagnosis / Q000601:surgery*; D002648:Child; D016292:Procedural Sedation / Q000379:methods*; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D018570:Risk Assessment; D012720:Severity of Illness Index; D013788:Thalamus / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D020927:Dexmedetomidine