title: Biologically active quassinoids and their chemistry: potential leads for drug design.
abstract: Quassinoids are highly oxygenated triterpenes, which were isolated as bitter principles from the plants of Simaroubaceae family. Their synthesis has attracted much attention because of the wide spectrum of their biological properties. The most prevalent quassinoids have C-20 picrasane skeleton, some known as bruceolides as they were isolated from the genus Brucea, which showed marked antileukemic and antimalarial activities.
authors.affiliation: Department of Medicinal Chemistry and Laboratory for Applied Drug Design and Synthesis, The University of Mississippi, University, Mississippi 38677, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Guo
authors.forename: S
authors.initials: S
authors.lastname: Vangapandu
authors.forename: R W
authors.initials: RW
authors.lastname: Sindelar
authors.forename: L A
authors.initials: LA
authors.lastname: Walker
authors.forename: R D
authors.initials: RD
authors.lastname: Sindelar
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D032269:Brucea / Q000737:chemistry; D015195:Drug Design; D010946:Plants, Medicinal / Q000737:chemistry*; D021281:Quantitative Structure-Activity Relationship; D036702:Quassins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D036702:Quassins; D014315:Triterpenes