[Blood concentration of homocysteine, vitamin B (12), and folic acid in patients with exudative age related macular degeneration].
OBJECTIVE
Recent studies have shown a relationship between elevated levels of Hcy and vascular disease including cerebrovascular accidents and myocardial infarctions. Elevated Hcy plasma is considered as an independent risk factor for atherosclerosis and trombosis.


METHODS
This study included 30 patients with diagnosed exudative form of AMD. We evaluated plasma homocysteine levels, by high performance liquid chromatography and red blood cell folic acid, plasma folic acid and plasma vitamin B12 concentration by radioassay method.


RESULTS
The plasma concentration of Hcy in AMD patients had significantly increased when compared with control group. We found not significant decrease of the plasma vitamin B12, red blood cell folic acid and plasma folic acid concentration in AMD group, when compared with the control group.
Nowak
Mariusz
M
Zakładu Patofizjologii Katedry Patofizjologii i Endokrynologii Slaskiej Akademii Medycznej, Zabrze.
Szapska
Bozena
B
Swietochowska
Elibieta
E
Wielkoszyński
Tomasz
T
Marek
Bogdan
B
Kos-Kudła
Beata
B
Kajdaniuk
Dariusz
D
Głogowska-Szelag
Joanna
J
Siemińska
Lucyna
L
Ostrowska
Zofia
Z
D000368:Aged; D004912:Erythrocytes / Q000378:metabolism; D005492:Folic Acid / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008268:Macular Degeneration / Q000097:blood*; D014805:Vitamin B 12 / Q000097:blood*
D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12