Kinases regulating Golgi apparatus structure and function.
Protein kinases control Golgi function in both mitotic and interphase cells. In mitosis, phosphorylation of structural proteins by Cdk1 (cyclin-dependent kinase 1)-cyclin B, Polo-like and mitogen-activated protein kinases underlie changes in Golgi reorganization during cell division. While in interphase, signalling pathways that are associated with the Golgi control secretory function through a variety of mechanisms. Some of these, notably those involving protein kinase D and Ste20 family kinases, are also relevant for the establishment and maintenance of cell polarization and migration.
Preisinger
Christian
C
Max-Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried 82152, Germany.
Barr
Francis A
FA
D000818:Animals; D002465:Cell Movement; D016764:Cell Polarity; D006056:Golgi Apparatus / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D007399:Interphase; D008938:Mitosis; D011494:Protein Kinases / Q000502:physiology*; D015398:Signal Transduction
D011494:Protein Kinases