title: Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study.
abstract: In this double-blind clinical study, we evaluated the effect of our newly developed synthetic collagen-like hexapeptide on wrinkles. Twenty healthy women volunteers, aged 40 to 62 years old, participated in the study Volunteers applied either a gel formula containing 3% of the collagen-like peptide and 1% of a booster molecule that stimulates general cell metabolism with no specific effect on wrinkles, or a placebo gel, on the eye zone area twice a day for 4 weeks. Control visits were performed at the beginning and the end of the study. Skin wrinkles were evaluated clinically and by silicon replica analysis followed by statistical treatment using the matched-pairs Student's t-test. The results showed that application of the collagen-like peptide on the skin significantly reduced the total surface of wrinkles and this effect was observed in 75% of the replicas. Similarly, the decrease in number and average depth of wrinkles was also significant and was observed in 65% and 75% of the replicas, respectively. The effect of the collagen-like peptide on reducing the total and average length of wrinkles was also remarkable. This effect was statistically highly significant (p < 0.003) and was observed in 75% to 80% of the replicas. Moreover these results were supported by volunteer questionnaires and clinical observation. The results demonstrate that the collagen-like peptide acts deeply and intensely on wrinkles; these properties are of great interest in the field of antiaging skin care research.
authors.affiliation: Vincience Research Center, Sophia Antipolis, France.
authors.forename: E
authors.initials: E
authors.lastname: Bauza
authors.forename: G
authors.initials: G
authors.lastname: Oberto
authors.forename: A
authors.initials: A
authors.lastname: Berghi
authors.forename: C Farra
authors.initials: CF
authors.lastname: Dal
authors.forename: N
authors.initials: N
authors.lastname: Domloge
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003094:Collagen / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010455:Peptides / Q000008:administration & dosage / Q000235:genetics / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects*; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D010455:Peptides; D003094:Collagen