Two new cases of familial hairy cell leukemia associated with HLA haplotypes A2, B7, Bw4, Bw6.
Hairy cell leukemia (HCL) is a rare hematological disorder of unknown origin. Thirteen familial cases of HCL have been reported, with 28 relatives affected. Here we report 2 cases of HCL in a family associated with HLA haplotypes A2, B7 and Bw4/6.
Villemagne
Bruno
B
Hématologie clinique adulte, Pavillon Villemin Pasteur, Hôtel Dieu, Clermont Ferrand, France. bvillemagne@chu-clermontferrand.fr
Bay
Jacques-Olivier
JO
Tournilhac
Olivier
O
Chaleteix
Carine
C
Travade
Philippe
P
D000368:Aged; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics*; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; D015793:HLA-B7 Antigen; D006239:Haplotypes; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D006680:HLA Antigens; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; D015793:HLA-B7 Antigen; C042388:HLA-Bw4 antigen; C038652:HLA-Bw6 antigen