title: Cellular responses to mild heat stress.
abstract: Since its discovery in 1962 by Ritossa, the heat shock response has been extensively studied by a number of investigators to understand the molecular mechanism underlying the cellular response to heat stress. The most well characterized heat shock response is induction of the heat shock proteins that function as molecular chaperones and exert cell cycle regulatory and anti-apoptotic activities. While most investigators have focused their studies on the toxic effects of heat stress in organisms such as severe heat stress-induced cell cycle arrest and apoptosis, the cellular response to fever-ranged mild heat stress has been rather underestimated. However, the cellular response to mild heat stress is likely to be more important in a physiological sense than that to severe heat stress because the body temperature of homeothermic animals increases by only 1-2 degrees C during febrile diseases. Here we provide information that mild heat stress does have some beneficial role in organisms via positively regulating cell proliferation and differentiation, and immune response in mammalian cells.
authors.affiliation: Research Institute of Genetic Engineering, College of Natural Sciences, Pusan National University, Pusan 609-735, Korea.
authors.forename: H G
authors.initials: HG
authors.lastname: Park
authors.forename: S I
authors.initials: SI
authors.lastname: Han
authors.forename: S Y
authors.initials: SY
authors.lastname: Oh
authors.forename: H S
authors.initials: HS
authors.lastname: Kang
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D056741:Cyclin D; D016213:Cyclins / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D018869:Heat-Shock Response / Q000502:physiology*; D006358:Hot Temperature; D006801:Humans; D007109:Immunity; D008560:Membrane Fluidity / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013816:Thermodynamics
chemical_list: D056741:Cyclin D; D016213:Cyclins; D017346:Protein Serine-Threonine Kinases; D019204:GTP-Binding Proteins