title: Seroprevalence and force of infection of varicella-zoster virus in Luxembourg.
abstract: A serological prevalence survey was carried out in Luxembourg during 2000-2001 to determine the antibody status of the Luxembourg population against vaccine-preventable infections including varicella-zoster virus (VZV). ELISA tests performed on 2679 sera indicated that 96 (3.6%) of the study population were seronegative. Age-specific seroprevalence rose rapidly from approximately 70% at age 4 years to 90% at age 6 years to 95% at age 12 years. Significant heterogeneity of seroprevalence was observed between the six different primary schools. For age groups 0-5, 6-11 and 12+ years, we estimated an annual force of infection of 0.361 [95% confidence interval (CI) 0.31-0.415)], 0.204 (95% CI 0.12-0.29) and 0.05 (95% CI 0.024-0.082) respectively. Our results indicate that transmission of VZV is highest in children below the age of 6 years and that much lower levels of VZV transmission occur in secondary schools and throughout adulthood.
authors.affiliation: Laboratoire National de Santé, PO Box 1102, L-1011 Luxembourg. joel.mossong@lns.etat.lu
authors.forename: J
authors.initials: J
authors.lastname: Mossong
authors.forename: L
authors.initials: L
authors.lastname: Putz
authors.forename: F
authors.initials: F
authors.lastname: Schneider
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D002644:Chickenpox / Q000453:epidemiology* / Q000276:immunology* / Q000635:transmission; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D014645:Herpesvirus 3, Human / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008189:Luxembourg / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral