Supramolecular aggregates constructed from gold nanoparticles and l-try-CD polypseudorotaxanes as captors for fullerenes.
A series of cyclodextrin-based polypseudorotaxanes (PPRs) were constructed by threading native beta-cyclodextrin or l-tryptophan-modified beta-cyclodextrin onto the amino-terminated PPG chains of different lengths. Subsequently, these PPRs were further assembled to form netlike supramolecular aggregates through the linkage of gold nanoparticles, and the resulting water-soluble Au-PPR aggregates were comprehensively characterized by FT-IR, UV, NMR, fluorescence spectroscopy, powder X-ray diffraction patterning, TG-DTA, and transmission electron microscopy. The results showed that the size and sedimentation rate of the Au-PPR aggregates were mainly dependent on the lengths of the PPG chains. Significantly, the Au-PPR aggregate 8, involving many l-tryptophan residues, showed not only a satisfactory water solubility but also a good capturing ability for fullerenes in aqueous solution. The 8-fullerene conjugate thus formed exhibited a good DNA cleavage ability under light irradiation.
Liu
Yu
Y
Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China. yuliu@public.tpt.tj.cn
Wang
Hao
H
Chen
Yong
Y
Ke
Chen-Feng
CF
Liu
Min
M
D004247:DNA / Q000737:chemistry; D004355:Drug Stability; D037741:Fullerenes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006358:Hot Temperature; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D043823:Taxoids / Q000737:chemistry*; D013818:Thermogravimetry; D014364:Tryptophan / Q000031:analogs & derivatives / Q000737:chemistry*; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
D037741:Fullerenes; D011108:Polymers; D011409:Propylene Glycols; D043823:Taxoids; D047392:beta-Cyclodextrins; C012504:polypropylene glycol; D006046:Gold; D014364:Tryptophan; D004247:DNA; C031215:betadex; C069837:fullerene C60