S100B and NSE serum levels in patients with Parkinson's disease.
We evaluated S100B protein and neuron-specific enolase (NSE) serum levels in Parkinson's disease (PD) patients and their correlation with the severity of disease. The levels of S100B (P=0.16) and NSE (P=0.39) between PD and controls were similar. However, S100B levels correlated positively with the Hoehn and Yahr scale (r=0.368; P=0.02) and negatively with the Activities of Daily Living (ADL) scale (r=-0.431; P=0.006). Therefore, S100B and NSE may not have a diagnostic role in PD, but S100B may have a potential role as a marker of disease progression. The study of S100B may also contribute to elucidate the controversial role of glial cells in PD.
Schaf
Débora V
DV
Departamento de Bioquímica, ICBS, UFRGS, Ramiro Barcelos 2600 - ANEXO, 90035-003 Porto Alegre, RS, Brazil.
Tort
Adriano B L
AB
Fricke
Daniele
D
Schestatsky
Pedro
P
Portela
Luis V C
LV
Souza
Diogo O
DO
Rieder
Carlos R M
CR
D000368:Aged; D000375:Aging / Q000378:metabolism; D015415:Biomarkers; D005260:Female; D006801:Humans; D007120:Immunochemistry; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010300:Parkinson Disease / Q000097:blood* / Q000503:physiopathology; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D012189:Retrospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012727:Sex Characteristics
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D010751:Phosphopyruvate Hydratase