Functional magnetic resonance imaging and somatosensory evoked potentials in rats with a neonatally induced freeze lesion of the somatosensory cortex.
Brain plasticity is an important mechanism for functional recovery from a cerebral lesion. The authors aimed to visualize plasticity in adult rats with a neonatal freeze lesion in the somatosensory cortex using functional magnetic resonance imaging (fMRI), and hypothesized activation outside the primary projection area. A freeze lesion was induced in the right somatosensory cortex of newborn Wistar rats (n = 12). Sham-operated animals (n = 7) served as controls. After 6 or 7 months, a neurologic examination was followed by recording of somatosensory evoked potentials (SSEPs) and magnetic resonance experiments (anatomical images, fMRI with blood oxygen level-dependent contrast and perfusion-weighted imaging) with electrical forepaw stimulation under alpha-chloralose anesthesia. Lesioned animals had no obvious neurologic deficits. Anatomical magnetic resonance images showed a malformed cortex or hyperintense areas (cysts) in the lesioned hemisphere. SSEPs were distorted and smaller in amplitude, and fMRI activation was significantly weaker in the lesioned hemisphere. Only in a few animals were cortical areas outside the primary sensory cortex activated. The results are discussed in respect to an apparent absence of plasticity, loss of excitable tissue, the excitability of the lesioned hemisphere, altered connectivity, and a disturbed coupling of increased neuronal activity to the hemodynamic response.
Schwindt
Wolfram
W
Max-Planck-Institute for Neurological Research, Cologne, Germany. WSchwindt@uni-muenster.de
Burke
Michael
M
Pillekamp
Frank
F
Luhmann
Heiko J
HJ
Hoehn
Mathias
M
D000818:Animals; D000831:Animals, Newborn; D002560:Cerebrovascular Circulation / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005121:Extremities / Q000502:physiology; D005615:Freezing; D008279:Magnetic Resonance Imaging; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000473:pathology* / Q000503:physiopathology*