Evaluation of immunogenicity and side effects of triple viral vaccine (MMR) in adults, given by two routes: subcutaneous and respiratory (aerosol).
Adult volunteers from two neighboring health centers were immunized with measles, mumps, rubella vaccine (MMR, Serum Institute of India Ltd.), either given by traditional injections or by an aerosol delivered to the respiratory tract. Baseline and one month post vaccination samples were taken and simultaneously assayed for all three antigens. Subjects were followed-up for temporally associated events after vaccination. The aerosol route was superior for measles, mumps and rubella when baseline titers were controlled for in multivariate analysis. Frequencies of post-vaccination events did not differ with statistical significance between the groups. Further evaluation of the aerosol route for MMR immunization appears warranted.
Castro
Jorge Fernandez de
JF
National Institute of Public Health, Av. Universidad 655, Col. Sta. Maria, Ahuacatitian C.P. 62508, Cuernavaca, Mexico.
Bennett
John V
JV
Rincon
Hector Gallardo
HG
Munoz
M T Alvarez Y
MT
Sanchez
Luis Alfonso E Partida
LA
Santos
Jose Ignacio
JI
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D008875:Middle Aged; D015999:Multivariate Analysis; D012220:Rhinitis / Q000139:chemically induced / Q000276:immunology; D012894:Sleep Stages / Q000187:drug effects / Q000276:immunology
D000336:Aerosols; D022542:Measles-Mumps-Rubella Vaccine