Effects of lactoferrin, soya germ and polyamine on 2-amino-1-methyl-6- phenylimidazo[4,5-b]-pyridine(PhIP)- induced breast carcinogenesis in rats.
The cancer-preventive effects of food-derived bovine lactoferrin(bLF), isoflavone-rich soya germ(SG), and spermidine(SPD) on mammary gland carcinogenesis induced by 2-amino-1- methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP), were investigated in female Sprague-Dawley(SD) rats. Two hundred and six female SD rats were divided into 8 groups. Cumulative breast cancer incidence at 43 weeks was 65.4% in the PhIP group; 80.0% and 76.0% in the 0.2% and 2.0% bLF groups, respectively; 58.3% and 20.0% in the 2% and 10% SG groups, respectively; and 80.0% and 76.9% in the 0.035% and 0.175% SPD groups, respectively. Isoflavone-rich SG significantly suppressed breast cancer, and the tumors showed fibrous or less malignant features upon histological examination.
Haba
Ryota
R
Faculty of Applied Bioscience, Tokyo University of Agriculture 1-1-1 Sakuragaoka, Setagaya, Tokyo 156-8502, Japan.
Watanabe
Shaw
S
Wada
Masahiro
M
Udaka
Shigezo
S
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D007093:Imidazoles / Q000633:toxicity*; D007781:Lactoferrin / Q000494:pharmacology*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds; D013025:Glycine max
D002273:Carcinogens; D007093:Imidazoles; D010936:Plant Extracts; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; D007781:Lactoferrin