The role of host immunity in the control of HIV infection: from theory to diagnostic and therapeutic intervention.
Different immune and virological responses to antiretroviral therapy were generally observed in a consistent part of treated patients. The immune reconstitution due to viral decay conseguent to antiretroviral therapy is principally divided in two phases (redistribution and repopulation). Several co-factors (in particular co-receptor and cytokine relationship with HIV infection) can interfere with the response to the antiviral drugs. The re-establishment of HIV target cells immune activation and the reduction of CD4 cell loss and turn-over must be considered.
Lazzarin
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Clinic of Infectious Diseases, Vita-Salute San Raffaele University, Milan.
D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006678:HIV / Q000187:drug effects / Q000502:physiology; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D006801:Humans; D014766:Viremia