title: The crystal structure of annexin A8 is similar to that of annexin A3.
abstract: Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus. The structure is closest to that of annexin A3 and highlights several important regions of inherent flexibility in the annexin molecule. The N terminus resembles that of annexin A3, as it lies along the concave surface of the molecule and inserts partially into the hydrophilic channel in its centre. Since both annexins A3 and A8 are expressed in promyelocytic cells during their differentiation, the similarity in their structures might suggest a functional relationship.
authors.affiliation: LURE, Centre Universitaire Paris-Sud, BP 34, 91898 Orsay Cedex, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Réty
authors.forename: Jana
authors.initials: J
authors.lastname: Sopková-de Oliveira Santos
authors.forename: Lise
authors.initials: L
authors.lastname: Dreyfuss
authors.forename: Karine
authors.initials: K
authors.lastname: Blondeau
authors.forename: Katerina
authors.initials: K
authors.lastname: Hofbauerová
authors.forename: Céline
authors.initials: C
authors.lastname: Raguénès-Nicol
authors.forename: Daniel
authors.initials: D
authors.lastname: Kerboeuf
authors.forename: Madalena
authors.initials: M
authors.lastname: Renouard
authors.forename: Françoise
authors.initials: F
authors.lastname: Russo-Marie
authors.forename: Anita
authors.initials: A
authors.lastname: Lewit-Bentley
mesh_terms: D017318:Annexin A3 / Q000737:chemistry*; D017302:Annexins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D001665:Binding Sites; D002118:Calcium / Q000494:pharmacology; D018360:Crystallography, X-Ray; D008239:Lysine / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D009154:Mutation / Q000235:genetics; D011487:Protein Conformation
chemical_list: D017302:Annexins; D017318:Annexin A3; D008239:Lysine; D002118:Calcium