title: Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH.
abstract: The recent determination that Angeli's salt may have clinical application as a nitrogen oxide donor for treatment of cardiovascular diseases such as heart failure has led to renewed interest in the mechanism and products of thermal decomposition of Angeli's salt under physiological conditions. In this report, several mechanisms are evaluated experimentally and by quantum mechanical calculations to determine whether HNO is in fact released from Angeli's salt in neutral, aerobic solution. The mechanism of product autoxidation is also considered.
authors.affiliation: Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA. kmiranda@email.arizona.edu
authors.forename: Katrina M
authors.initials: KM
authors.lastname: Miranda
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Dutton
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Ridnour
authors.forename: Christian A
authors.initials: CA
authors.lastname: Foreman
authors.forename: Eleonora
authors.initials: E
authors.lastname: Ford
authors.forename: Nazareno
authors.initials: N
authors.lastname: Paolocci
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Katori
authors.forename: Carlo G
authors.initials: CG
authors.lastname: Tocchetti
authors.forename: Daniele
authors.initials: D
authors.lastname: Mancardi
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Thomas
authors.forename: Michael G
authors.initials: MG
authors.lastname: Espey
authors.forename: K N
authors.initials: KN
authors.lastname: Houk
authors.forename: Jon M
authors.initials: JM
authors.lastname: Fukuto
authors.forename: David A
authors.initials: DA
authors.lastname: Wink
mesh_terms: D006863:Hydrogen-Ion Concentration; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000378:metabolism; D009573:Nitrites / Q000737:chemistry* / Q000378:metabolism; D016877:Oxidants / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D011789:Quantum Theory; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013816:Thermodynamics
chemical_list: D020030:Nitric Oxide Donors; D009573:Nitrites; D016877:Oxidants; D012996:Solutions; C021229:oxyhyponitrite; D010100:Oxygen