title: Metal-enhanced fluorescence solution-based sensing platform.
abstract: In recent years our laboratories have reported the favorable effects for fluorophores placed in close proximity to surface immobilized silver nanostructures. These include; greater quantum yields, reduced lifetimes (increased photostability) and directional emission. However, while these findings are likely to find multifarious applications for surface assays based on enhanced fluorescence detection, a solution based enhanced sensing platform has yet to be realized. In this short, note, we show how SiO2-coated silver colloids, indeed provide for a solution based enhanced fluorescence sensing platform with a 3-5 fold enhancement typically observed.
authors.affiliation: Institute of Fluorescence, Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland, USA.
authors.forename: Kadir
authors.initials: K
authors.lastname: Asian
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Lakowicz
authors.forename: Henryk
authors.initials: H
authors.lastname: Szmacinski
authors.forename: Chris D
authors.initials: CD
authors.lastname: Geddes
mesh_terms: D003102:Colloids; D005453:Fluorescence; D005456:Fluorescent Dyes; D008670:Metals; D049329:Nanostructures; D012822:Silicon Dioxide; D012834:Silver; D012996:Solutions; D013499:Surface Properties
chemical_list: D003102:Colloids; D005456:Fluorescent Dyes; D008670:Metals; D012996:Solutions; D012834:Silver; D012822:Silicon Dioxide