title: [Synaptonemal complexes analysis in male fertility impairment in two men].
abstract: Synaptonemal complexes (SCs) of male fertility impairment were analysed in two patients. In case one, his testicular histology was normal and there were 20% abnormal pachytene spermatoeytes, showing unsynaptic and broken SCs. It resulted in spermatogensis with unbalanced chromosomes and pregnancy wastages. In case two, he had no sperms basically. G-banded chromosome analysis of lymphocytes showed normal chromosomal karyotype, but triple fragment, lateral element swelling and fragment breakages of SCs were observed in his spermatocytes. The mechanisms of infertility,impairment of fertility for the observed men were discussed in this paper.
authors.affiliation: The Key Laboratory of the Ministry of Education of Plant Developmental Biology, Wuhan University, Wuhan 430072, China.
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Liu
authors.forename: Xiao-Ran
authors.initials: XR
authors.lastname: Wang
authors.forename: Xian-Lu
authors.initials: XL
authors.lastname: Zeng
authors.forename: Yun-Chun
authors.initials: YC
authors.lastname: Song
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000235:genetics* / Q000473:pathology; D002872:Chromosome Deletion; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology; D007621:Karyotyping; D008297:Male; D009006:Monosomy; D013090:Spermatocytes / Q000378:metabolism* / Q000473:pathology; D013091:Spermatogenesis / Q000235:genetics; D013573:Synaptonemal Complex; D014314:Trisomy