title: [Autoantibodies in relatives of IgA-deficient patients].
abstract: Selective IgA deficiency is frequently associated with autoimmune phenomena. We addressed the question, whether autoantibodies are more frequent in relatives of IgA deficient persons. Fifteen first-degree relatives of patients with a familial form of IgA deficiency and 129 first-degree relatives of patients with a sporadic form of IgA deficiency were evaluated. Following autoantibodies were detected: antinuclear, anti-thyreoglobulin, anti-thyroid microsomal, anti-gastric parietal cell, anti-reticulin, anti-smooth muscle, anti-mitochondrial, anti-neutrophil cytoplasmatic, anti-cardiolipin, rheumatoid factor and antibodies against gliadin. We did not find increase in any of the autoantibodies evaluated in any groups of patients. Our results do not support a significant genetic influence in autoantibodies formation in selective IgA deficiency.
authors.affiliation: Ustav klinické imunologie a alergologie Lékarské fakulty MU Brno a Fakultní nemocnice u sv. Anny, Brno.
authors.forename: J
authors.initials: J
authors.lastname: Litzman
authors.forename: D
authors.initials: D
authors.lastname: Bartonková
authors.forename: D
authors.initials: D
authors.lastname: Stikarovská
authors.forename: Z
authors.initials: Z
authors.lastname: Pikulová
authors.forename: J
authors.initials: J
authors.lastname: Lokaj
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D001323:Autoantibodies