Structure prediction of membrane proteins.
There is a large gap between the number of membrane protein (MP) sequences and that of their decoded 3D structures, especially high-resolution structures, due to difficulties in crystal preparation of MPs. However, detailed knowledge of the 3D structure is required for the fundamental understanding of the function of an MP and the interactions between the protein and its inhibitors or activators. In this paper, some computational approaches that have been used to predict MP structures are discussed and compared.
Zhou
Chunlong
C
Hangzhou Genomics Institute/James D. Watson Institute for Genome Sciences, Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310008, China.
Zheng
Yao
Y
Zhou
Yan
Y
D019295:Computational Biology / Q000379:methods*; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics*; D008958:Models, Molecular; D011487:Protein Conformation
D008565:Membrane Proteins