title: [Hepatitis C virus RNA in the skin eruption from patients with prurigo and chronic hepatitis C].
abstract: Hepatitis C virus RNA in the skin eruption from patients with prurigo and chronic hepatitis C. Since the discovery of hepatitis C virus (HCV) in 1989, many cutaneous disorders have been observed in patients suffering from chronic HCV infection. The relationship between HCV infection and cryoglobulinemia and porphyria cutanea tarda is clearly established, however, the link between HCV and other skin diseases is still controversial.
  
  
  OBJECTIVE
  Two patients with intense pruritus and secondary prurigo in chronic C hepatitis have been presented.
  
  
  METHODS
  The chronic hepatitis C of the patients were proved by elevated ALT and AST level, anti HCV (ELISA), HCV-PCR serological examination and liver biopsy. The skin lesions were accompanied by severe itching. According to clinical symptoms the patients suffered from prurigo simplex.
  
  
  RESULTS
  HCV RNA in the skin specimen from the biopsy of the skin lesion was detected by RT PCR method, but the non affected skin specimen from the patients was HCV RNA negative.
  
  
  CONCLUSIONS
  This report is a case of prurigo simplex with chronic C hepatitis proving a direct relation between the HCV infection and prurigo.
authors.affiliation: Országos Bor és Nemikórtani Intézet.
authors.forename: Beáta
authors.initials: B
authors.lastname: Podányi
authors.forename: András
authors.initials: A
authors.lastname: Kiss
authors.forename: Pál
authors.initials: P
authors.lastname: Kaposi Novák
authors.forename: Csilla
authors.initials: C
authors.lastname: Páska
authors.forename: Gabriella
authors.initials: G
authors.lastname: Lengyel
authors.forename: Margit
authors.initials: M
authors.lastname: Horányi
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Schaff
authors.forename: Attila
authors.initials: A
authors.lastname: Horváth
mesh_terms: D005260:Female; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D011536:Prurigo / Q000821:virology*; D012367:RNA, Viral / Q000302:isolation & purification*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000821:virology*
chemical_list: D012367:RNA, Viral