title: A case of bronchiolitis obliterans organizing pneumonia syndrome with preceding radiation pneumonitis after breast-conserving therapy.
abstract: Recent case series have demonstrated that bronchiolitis obliterans organizing pneumonia (BOOP) after radiation therapy to the breast is a distinct clinicopathological entity. Most of the investigators speculated that radiation may prime the development of BOOP through an unidentified immunological process; however, none of them showed the relationship between direct radiation injury and BOOP. We report herein a case of a 67-year-old female with BOOP following direct radiation damage confined to the irradiated area after breast-conserving therapy. This is the first case demonstrating that BOOP after breast-conserving therapy arises from direct radiation injury.
authors.affiliation: Department of Radiology, Chiba University Hospital, Chuo-ku, Chiba 260-8670, Japan. isobeko@ho.chiba-u.ac.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Isobe
authors.forename: Takashi
authors.initials: T
authors.lastname: Uno
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawakami
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Ueno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yagata
authors.forename: Natsuhiko
authors.initials: N
authors.lastname: Igarashi
authors.forename: Hisao
authors.initials: H
authors.lastname: Ito
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D018549:Cryptogenic Organizing Pneumonia / Q000000981:diagnostic imaging / Q000209:etiology*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D017564:Radiation Pneumonitis / Q000000981:diagnostic imaging / Q000209:etiology*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed