Synthesis and antiviral evaluation of D4T analogues with a spacer arm between glucidic and base moieties.
The synthesis of a series of d4T analogues bearing an acyclic chains between the sugar and the base moities, is described. New compounds were obtained readily using microwave irradiation and selective deprotection of sugar part. The compounds were characterized by 1H NMR and IR spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.
Roy
Vincent
V
Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Université de Limoges, Limoges, France.
Zerrouki
Rachida
R
Krausz
Pierre
P
Schmidt
Sylvie
S
Aubertin
Anne Marie
AM
D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D018119:Stavudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D018894:Reverse Transcriptase Inhibitors; D018119:Stavudine