Reduction of freeze-thaw-induced hemolysis of red blood cells by an algal ice-binding protein.
Antarctic sea ice diatoms produce ice-binding proteins (IBPs) that are strong inhibitors of the recrystallization of ice. Their function may be to reduce cell damage in the frozen state. We show here that an IBP from the diatom Navicula glaciei Vanheurck also has the ability to reduce freeze-thaw damage to red blood cells and that the effect may be due to its ability to inhibit recrystallization of ice.
Kang
Jae-Shin
JS
Department of Biological Sciences, University of Nevada, Las Vegas 89154, USA.
Raymond
James A
JA
D000864:Antarctic Regions; D001793:Blood Preservation / Q000379:methods*; D015925:Cryopreservation / Q000379:methods*; D017377:Diatoms / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007053:Ice; D010940:Plant Proteins / Q000494:pharmacology*
D007053:Ice; D010940:Plant Proteins