Synthesis and activity of 2-oxoamides containing long chain beta-amino acids.
2-Oxoamides based on long chain beta-amino acids were synthesized. 1-Benzyl substituted long chain amines, needed for such synthesis, were synthesized starting from Boc-phenylalaninol. The oxidative conversion of a phenyl group to a carboxyl group was used as the key transformation synthetic step. The compounds synthesized were studied for their activity against GIVA PLA(2), and were proven to be weak inhibitors.
Constantinou-Kokotou
Violetta
V
Chemical Laboratories, Agricultural University of Athens, Iera Odos 75, Athens 11855, Greece.
Peristeraki
Anna
A
Kokotos
Christoforos G
CG
Six
David A
DA
Dennis
Edward A
EA
D000596:Amino Acids / Q000378:metabolism*; D005563:Formic Acid Esters / Q000378:metabolism; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D011725:Pyridines / Q000138:chemical synthesis*
D000596:Amino Acids; D005563:Formic Acid Esters; D011725:Pyridines; C000345:t-butyloxycarbonyl group; C012481:phenylalaninol; D010649:Phenylalanine; C034960:oxoamide; D010741:Phospholipases A