title: Expression of IAPs and alternative splice variants in hepatocellular carcinoma tissues and cells.
abstract: IAPs (inhibitors of apoptosis proteins) might have a major role in the apoptotic resistance that marks many cancers. The studies on IAPs in human HCC have focused on survivin or XIAP, indicating that their new or increased expression in this tumor is associated with a more unfavorable prognosis. The present results corroborate these findings, emphasizing the role that the coordinated expression of different IAPs and alternative splice variants might play in the adverse biology of hepatocellular carcinoma.
authors.affiliation: Dipartimento di Scienze Farmacologiche, Università di Palermo, Via del Vespro 129, 90127 Palermo, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Notarbartolo
authors.forename: Melchiorre
authors.initials: M
authors.lastname: Cervello
authors.forename: Lydia
authors.initials: L
authors.lastname: Giannitrapani
authors.forename: Maria
authors.initials: M
authors.lastname: Meli
authors.forename: Paola
authors.initials: P
authors.lastname: Poma
authors.forename: Luisa
authors.initials: L
authors.lastname: Dusonchet
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Montalto
authors.forename: Natale
authors.initials: N
authors.lastname: D'Alessandro
mesh_terms: D017398:Alternative Splicing; D017209:Apoptosis; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D019008:Drug Resistance, Neoplasm; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism*; D011379:Prognosis; D011506:Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051636:X-Linked Inhibitor of Apoptosis Protein
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D012333:RNA, Messenger; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human