title: Perinatal essential fatty acid deficiency influences body weight and bone parameters in adult male rats.
abstract: Fetal and postnatal nutrition have long-term effects on the risk for development of diseases late in life in humans and animals. The aim of the present study was to investigate the effect of dietary deficiency of essential fatty acids (EFA) in the perinatal period on later body weight and bone mass. During late gestation and throughout lactation, rats were fed a control or an EFA-deficient (EFAD) diet. At 3 weeks of age the offspring were weaned onto an ordinary chow and followed until adult age. The mean body weight of adult rats receiving the EFAD diet during the perinatal period was significantly increased from 12 weeks of age compared to the controls (P<0.05). Analysis by peripheral quantitative computerized tomography (pQCT) at 44 weeks of age showed that the trabecular volumetric bone mineral density (BMD) of the femur was significantly decreased (P<0.05) but the cortical bone mineral content, cortical area, and cortical thickness were increased (P<0.05) in the EFAD group of rats. The length of the femur was not affected. In conclusion, neonatal EFA deficiency was in adult rats associated with increased body weight and significant changes in both cortical and trabecular bone. The results indicate that regulatory mechanisms related to bone mass seemed to be programmed by EFA in the perinatal period. The nature of this modulation needs to be identified.
authors.affiliation: Department of Pediatrics, Göteborg University, The Queen Silvia Children's Hospital, SE 41685 Göteborg, Sweden. Marina.Korotkova@cmm.ki.se
authors.forename: M
authors.initials: M
authors.lastname: Korotkova
authors.forename: C
authors.initials: C
authors.lastname: Ohlsson
authors.forename: B
authors.initials: B
authors.lastname: Gabrielsson
authors.forename: L A
authors.initials: LA
authors.lastname: Hanson
authors.forename: B
authors.initials: B
authors.lastname: Strandvik
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D001846:Bone Development; D001842:Bone and Bones / Q000378:metabolism; D005228:Fatty Acids, Essential / Q000097:blood / Q000172:deficiency*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D020738:Leptin / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005228:Fatty Acids, Essential; D020738:Leptin; D007334:Insulin-Like Growth Factor I