title: Keratosis lichenoides chronica and eruptive keratoacanthoma-like lesions in a patient with multiple myeloma.
abstract: We describe a 72-year-old woman with a 13-year history of a lichenoid dermatitis, who developed multiple, papular keratoacanthoma (KA)-like lesions and few crater-like nodules on the extremities over a period of 6 months before our observation. Her medical history also recorded multiple myeloma diagnosed a few years before. The long-standing dermatosis was diagnosed, clinically, as keratosis lichenoides chronica (KLC), although, histologically, a lichenoid tissue reaction pattern was not evident. On the other hand, histology from papular and nodular lesions of recent onset was consistent with a possible early phase of KA and spinocellular carcinoma, respectively. Oral acitretin induced regression of KA-like lesions and improvement of KLC but had no effects on crater-like nodules, which required surgical excision. KLC is a chronic disorder of keratinization characterized by lichenoid hyperkeratotic papules arranged in a linear pattern, erythematosquamous plaques and seborrhoea-like dermatitis. We emphasize in our case the association between KLC and multiple possible KAs, never previously reported, and speculate that these two rare conditions may represent here a 'continuum' from a pathogenetic point of view.
authors.affiliation: Institute of Dermatological Sciences, University of Milan, IRCCS Ospedale Maggiore of Milan, Via Pace 9, 20122 Milan, Italy. scienze.dermatologiche@unimi.it
authors.forename: A V
authors.initials: AV
authors.lastname: Marzano
authors.forename: M
authors.initials: M
authors.lastname: Bellinvia
authors.forename: R
authors.initials: R
authors.lastname: Caputo
authors.forename: E
authors.initials: E
authors.lastname: Alessi
mesh_terms: D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007636:Keratoacanthoma / Q000473:pathology*; D007642:Keratosis / Q000473:pathology*; D017512:Lichenoid Eruptions / Q000473:pathology*; D009101:Multiple Myeloma / Q000473:pathology*