[Study on bone marrow microvascular density in hematological diseases].
To investigate the state and significance of bone marrow angiogenesis in hematological diseases, bone marrow microvascular density (BM-MVD) in plastic-embedded section was examined using acetone-fixed bone marrow tissues embedded in glycol-methacrylate (GMA) resin and by the method of immunohistochemistry. The results showed that bone marrow MVD increased greatly in newly diagnosed hematological malignancies before treatment. BM-MVD in patients with acute leukemia decreased down to the normal range as the controls at the time of complete remission. In the non-remission group, BM-MVD decreased less, but when relapsed it increased again up to the same range as the newly diagnosed hematological malignancies, significant increase of BM-MVD was found in patients with anemia, but in less degree than that in hematological malignancies. It is concluded that bone marrow angiogenesis plays a key role in the pathogenesis and development of hematological malignancy. Antiangiogenic therapy may be able to constitute a novel strategy for the treatment of hematological malignancies including leukemia.
Gao
Wu
W
Department of Hematology and Oncology, The First Hospital of Jilin University, Changchun 130021, China.
Song
Yan-Qiu
YQ
Li
Wei
W
Wang
Guan-Jun
GJ
D000208:Acute Disease; D001853:Bone Marrow / Q000098:blood supply* / Q000473:pathology; D006402:Hematologic Diseases / Q000097:blood / Q000473:pathology*; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000473:pathology; D008833:Microcirculation; D009389:Neovascularization, Pathologic / Q000097:blood / Q000473:pathology*