title: Ethnic differences in cerebral venous thrombosis.
abstract: BACKGROUND
  Cerebral venous thromboses (CVT) with distinct clinical presentations have been shown worldwide. However, there is little information regarding race-ethnic differences in this disease.
  
  
  METHODS
  We prospectively studied 50 CVT patients from Brazil, comparing clinical and laboratory data among white (W) and African-Brazilian (AB) patients.
  
  
  RESULTS
  Seventy percent of the patients were female, 26 W and 23 AB, mean age 34.7 years. Multiple sinus CVT, deep CVT and worse outcome were significantly more frequent in AB than in W patients. There was a trend towards a higher frequency of factor V Leiden and prothrombin mutation in W than in AB, and of protein C deficiency in AB.
  
  
  CONCLUSIONS
  CVT was more severe in AB patients than in W patients. Race-ethnic differences may account for the heterogeneous distribution of inherited thrombophilia in this series.
authors.affiliation: Department of Neurology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. ecamargo@partners.org
authors.forename: Erica Cristina Sá de
authors.initials: EC
authors.lastname: Camargo
authors.forename: Ayrton Roberto
authors.initials: AR
authors.lastname: Massaro
authors.forename: Luiz Alberto
authors.initials: LA
authors.lastname: Bacheschi
authors.forename: Elbio Antônio
authors.initials: EA
authors.lastname: D'Amico
authors.forename: Paula Ribeiro
authors.initials: PR
authors.lastname: Villaça
authors.forename: Rogério Pastore
authors.initials: RP
authors.lastname: Bassitt
authors.forename: Sandra Fátima
authors.initials: SF
authors.lastname: Gualandro
authors.forename: Israel
authors.initials: I
authors.lastname: Bendit
authors.forename: Milberto
authors.initials: M
authors.lastname: Scaff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D044383:Black People; D001938:Brazil / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000208:ethnology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D014505:Urban Population; D020246:Venous Thrombosis / Q000208:ethnology*; D044465:White People