[Advances in allelic polymorphism at class II of the pig MHC(SLA)].
This article gave a detailed introduction about regional map,molecular structure,genotyping and polymorphism of SLA class II genes. The pig major histocompatibility complex (MHC) class II antigens have been known to exhibit a different degree of allelic polymorphism. The locus-specific oligonucleotide primers and RFLP analysis provide a simple and rapid method for genotyping expressed SLA class II from genomic DNA. SLA class II polymorphism was related to the antigenic peptide binding sites. Detailed analysis of sequences showed that there were 4 GC-rich sequences in exon 2 of SLA-DQB and SLA-DRB1 genes.
Zhou
Bo
B
College of Animal Science, Nanjing Agricultural University, Nanjing 210095, China.
Wang
Lin-Yun
LY
Tan
Yong-Song
YS
Zhang
Shi-Qing
SQ