Identification and characterisation of a novel splice variant of the human CB1 receptor.
Cannabinoid ligands are implicated in many physiological processes and to date two receptors have been identified. However, a growing body of evidence exists that suggests the presence of additional receptors. Whilst cloning the previously described hCB1a, we have identified a novel variant that we call hCB1b. Characterising these two splice variants demonstrates that they have a unique pharmacological profile and that their RNA's are expressed at low levels in a variety of tissues.
Ryberg
Erik
E
Department of Molecular Pharmacology, AstraZeneca R&D, Mölndal, Sweden.
Vu
Huy Khang
HK
Larsson
Niklas
N
Groblewski
Thierry
T
Hjorth
Stephan
S
Elebring
Thomas
T
Sjögren
Sven
S
Greasley
Peter J
PJ
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001667:Binding, Competitive; D002186:Cannabinoids / Q000737:chemistry / Q000494:pharmacology; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects; D015870:Gene Expression; D015723:Gene Library; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000737:chemistry; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics* / Q000378:metabolism
D002186:Cannabinoids; D008024:Ligands; D043884:Receptor, Cannabinoid, CB1; D016244:Guanosine 5'-O-(3-Thiotriphosphate)