title: Functional 3.0-T MR assessment of higher cognitive function: are there advantages over 1.5-T imaging?
abstract: OBJECTIVE
  To compare cortical activation patterns associated with manual motor decision tasks at 1.5- and 3.0-T functional magnetic resonance (MR) imaging.
  
  
  METHODS
  The local ethics committee approved this study, and informed written consent was obtained. Ten right-handed healthy volunteers (eight men and two women; mean age, 35 years +/- 7 [standard deviation]) underwent functional MR imaging twice, once at 1.5 T and once at 3.0 T, while performing cognitive tasks that demanded manual motor decisions (letter-finger matching and lexical and semantic decisions). While stimulus presentation was blocked, an event-related model was employed to analyze subjects' individual responses. A group analysis of functional data was performed with a t test of 1.5- and 3.0-T results in the 10 subjects.
  
  
  RESULTS
  Manual motor decisions activated a widespread network of motor- (primary motor, posterior parietal) and decision-related areas (superior frontal cortex or anterior cingulate) at both field strengths (P <.05, corrected). Moreover, additional functional activation was detected in medial (supplementary motor area) and dorsal premotor regions (P <.05, corrected) at 3.0-T functional MR imaging, which was not detectable with corresponding 1.5-T imaging. The mean t value for peak voxels in activated areas detectable with both systems was 1.3 times larger at 3.0 T than that at 1.5 T.
  
  
  CONCLUSIONS
  Functional 3.0-T MR imaging allows detection of additional activation in cortical areas involved in higher executive motor functions compared with functional 1.5-T MR imaging.
authors.affiliation: Department of Radiology, University of Bonn, Sigmund-Freud-Str 25, D-53105 Bonn, Germany. k.hoenig@uni-bonn.de
authors.forename: Klaus
authors.initials: K
authors.lastname: Hoenig
authors.forename: Christiane K
authors.initials: CK
authors.lastname: Kuhl
authors.forename: Lukas
authors.initials: L
authors.lastname: Scheef
mesh_terms: D000328:Adult; D001931:Brain Mapping; D017352:Echo-Planar Imaging; D005260:Female; D005385:Fingers / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009048:Motor Skills / Q000502:physiology