[The content of immunoglobulins in blood serum of asymptomatic carriers of HBsAg with alcoholism].
The purpose of the case study was to investigate the concomitant influence of HBsAg and of alcohol on the content of immunoglobulins in blood serum, since the immunoglobulins are an important parameter of immunoreactivity. The study showed the patients with alcoholism to have a higher content of IgA and IgM versus healthy subjects. At the same time, the carriers of HBsAg with alcoholism had the level of IgG by 20% higher and a 2-fold higher concentration of IgA versus healthy subjects. The content of IgG and IgA was higher and that of IgM lower in blood serum of the HBsAg carriers with alcoholism versus the parameters observed in patients with alcoholism of the control group. Thus, patients with alcoholism who had concomitant effects from HBsAg and from alcohol had a potentiatedly higher content of IgA and IgG in blood serum. A lack of growth in the IgM level as observed in blood serum of patients with alcoholism due to HBsAg can be regarded as a prognostically unfavorable sign in the sense of HBsAg persistence and possible development of chronic viral hepatitis B.
Makarov
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VK
D000328:Adult; D000437:Alcoholism / Q000276:immunology*; D002353:Carrier State; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D006514:Hepatitis B Surface Antigens; D007136:Immunoglobulins