title: DPIV measurements of flow disturbances in stented artery models: adverse affects of compliance mismatch.
abstract: Vascular stents influence the post-procedural hemodynamic environment in ways that may encourage restenosis. Understanding how stents influence flow patterns may lead to more hemodynamically compatible stent designs that alleviate thrombus formation and promote endothelialization. This study employed time-resolved Digital Particle Image Velocimetry (DPIV) to compare the hemodynamic performance of two stents in a compliant vessel. The first stent was a rigid insert, representing an extreme compliance mismatch. The second stent was a commercially available nitinol stent with some flexural characteristics. DPIV showed that compliance mismatch promotes the formation of a ring vortex in the vicinity of the stent. Larger compliance mismatch increased both the size and residence time of the ring vortex, and introduced in-flow stagnation points. These results provide detailed quantitative evidence of the hemodynamic effect of stent mechanical properties. Better understanding of these characteristics will provide valuable information for modifying stent design in order to promote long-term patency.
authors.affiliation: Department of Biomedical Engineering, Wake Forest University, Medical Center Blvd., Winston-Salem, NC 27157-1022, USA. syazdani@wfubmc.edu
authors.forename: Saami K
authors.initials: SK
authors.lastname: Yazdani
authors.forename: James E
authors.initials: JE
authors.lastname: Moore
authors.forename: Joel L
authors.initials: JL
authors.lastname: Berry
authors.forename: Pavlos P
authors.initials: PP
authors.lastname: Vlachos
mesh_terms: D000818:Animals; D001158:Arteries / Q000502:physiology* / Q000601:surgery*; D001783:Blood Flow Velocity / Q000502:physiology*; D001807:Blood Vessel Prosthesis; D003187:Compliance; D019544:Equipment Failure Analysis / Q000379:methods*; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology; D015607:Stents