title: Ent-kauranoids from Isodon rubescens var. taihangensis.
abstract: Two new compounds, rubescensins Q and R (1 and 2), and a new acetonide derivative (3) of lasiodonin, together with thirteen known analogues, oridonin (4), ponicidin (5), wikstroemioidin B (6), lasiodonin (7), lasiokaurin (8), enmenol (9), 1-O-beta-D-glucopyranosyl-enmenol (10), trichokaurin (11), the acetonide of maoyecrystal F (12), rabdoternins A-D (13-16), have been isolated from Isodon rubescens var. taihangensis. The structures of the new compounds were elucidated on the basis of spectroscopic methods, especially the 2D NMR spectral analysis. Compound 3 exhibited cytotoxicity against K562, Bcap37, CA, CNE, BIU87, BGC823, and HeLa cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China.
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Ma-Lin
authors.initials: ML
authors.lastname: Li
authors.forename: Yi-Kun
authors.initials: YK
authors.lastname: Mou
authors.forename: Qing-E
authors.initials: QE
authors.lastname: Tian
authors.forename: Si-Wei
authors.initials: SW
authors.lastname: Li
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D000091402:Prohibitins
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; C000717331:PHB2 protein, human; D000091402:Prohibitins; C497265:rubescensin Q; C497266:rubescensin R