Usefulness of C-reactive protein as an independent predictor of death in patients with ischemic cardiomyopathy.
The usefulness of serum C-reactive protein, an inflammatory marker, to predict mortality risk in patients who have ischemic cardiomyopathy was investigated. C-reactive protein was measured in 123 men who underwent cardiac catheterization and were noted to have left ventricular ejection fraction <or=45% and significant angiographic coronary artery disease. They were prospectively followed for 3 years. Higher levels of C-reactive protein were associated with increased mortality rate. This correlation was independent of other prognostic factors, such as age, ejection fraction, symptoms of severe congestive heart failure, use of angiotensin-converting enzyme inhibitors, and use of beta blockers.
Chirinos
Julio A
JA
Division of Cardiology, Department of Medicine, University of Miami School of Medicine and Veterans Affairs Medical Center, Miami, Florida 33125, USA.
Zambrano
Juan P
JP
Chakko
Simon
S
Schob
Alan
A
Veerani
Anila
A
Perez
Guido O
GO
Mendez
Armando J
AJ
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000401:mortality*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies
D015415:Biomarkers; D002097:C-Reactive Protein