[Gastrointestinal complications under NSAID treatment in the doctor's office].
In a prospective study, the incidence of asymptomatic NSAID-induced lesions in 104 patients was investigated. Treatment applied was mainly with diclofenac (n=67), ibuprofen (n=22) and rofecoxib (n=9). Overall, 44% of the study participants developed either treatment-requiring dyspeptic complaints, an ulcer, or both.
Hollenz
M
M
Medizinische Klinik, Jung-Stilling-Krankenhaus, Akademisches Lehrkrankenhaus der Universität Bonn, Siegen.
Labenz
J
J
D000428:Alcohol Drinking / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001168:Arthritis / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004415:Dyspepsia / Q000139:chemically induced / Q000175:diagnosis; D016145:Endoscopy, Digestive System; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000009:adverse effects*; D007783:Lactones / Q000008:administration & dosage / Q000009:adverse effects*; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000175:diagnosis; D012907:Smoking / Q000009:adverse effects; D013166:Spondylitis / Q000188:drug therapy; D013450:Sulfones / Q000008:administration & dosage / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib; D004008:Diclofenac; D007052:Ibuprofen