title: The effect of adult hemoglobin on red blood cell nitric oxide levels during fetal development.
abstract: OBJECTIVE
  To compare the levels of S-nitrosohemoglobin (HbSNO) at different gestational ages in newborn infants and correlate the levels of HbSNO with HbA and HbF.
  
  
  METHODS
  Cord blood samples of 22 newborn infants of different gestational ages (25-41 weeks) were analyzed. The levels of HbF and HbA were determined by HPLC and of HbSNO by chemiluminescence.
  
  
  RESULTS
  The level of HbSNO varied from 28.1 to 145.3 nM. There was a significant correlation with gestational age (r(2) = 0.5469, p < 0.0001) and with the relative amount of HbA (r(2) = 0.8144, p < 0.0001).
  
  
  CONCLUSIONS
  The increases in HbSNO in fetal red cells is directly related to the relative amount of HbA.
authors.affiliation: Pediatric Department, Sainte-Justine's Hospital, University of Montreal, Montreal, Canada. harry.bard@umontreal.ca
authors.forename: Harry
authors.initials: H
authors.lastname: Bard
authors.forename: Ann M
authors.initials: AM
authors.lastname: English
authors.forename: Carmen
authors.initials: C
authors.lastname: Gagnon
authors.forename: Karine
authors.initials: K
authors.lastname: Bellemin
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000378:metabolism*; D005312:Fetal Blood; D047109:Fetal Development; D005319:Fetal Hemoglobin / Q000378:metabolism*; D006441:Hemoglobin A / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D008163:Luminescent Measurements
chemical_list: D006454:Hemoglobins; C103574:S-nitrosohemoglobin; D006441:Hemoglobin A; D005319:Fetal Hemoglobin