title: Recurrent multiple hepatic abscesses, hepatic calcification and congenital hearing loss in a child with chronic granulomatous disease.
abstract: Chronic granulomatous disease (CGD) is a rare inherited primary immunodeficiency in which phagocytes cannot destroy catalase-positive bacteria and fungi. In this article, we describe a 6-year-old boy with CGD associated with recurrent multiple hepatic abscesses, hepatic calcification and congenital hearing loss because of rare presentation. To the best of our knowledge, congenital hearing loss in CGD has not been reported in the literature. In the treatment of our patient, a combination of antibiotherapy, percutaneous drainage and surgical intervention was used, but multiple hepatic abscesses recurred during the follow-up. On account of this case, we would like to reemphasize that recurrent hepatic abscesses are frequently observed and difficult to treat in patients with CGD. Additionally, we would like to state that congenital hearing loss may be a part of the disease, or it may be coincidental. To clarify the last point, we suggest that all patients with CGD should be tested for hearing impairment.
authors.affiliation: Associate Professor in Pediatrics, Yüzuncü Yil University Faculty of Medicine, Van, Turkey. huseyincaksen@hotmail.com
authors.forename: Huseyin
authors.initials: H
authors.lastname: Caksen
authors.forename: Turkan
authors.initials: T
authors.lastname: Patiroğlu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erol
authors.forename: Muammer Hakan
authors.initials: MH
authors.lastname: Poyrazoğlu
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000583:Amikacin / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002114:Calcinosis; D002675:Child, Preschool; D003248:Constipation / Q000209:etiology; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005334:Fever / Q000209:etiology / Q000628:therapy; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006312:Hearing Loss, Bilateral / Q000151:congenital / Q000209:etiology; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage / Q000627:therapeutic use; D008099:Liver / Q000473:pathology*; D008100:Liver Abscess / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D012008:Recurrence; D012867:Skin / Q000473:pathology; D013396:Suction; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem; D000583:Amikacin