title: Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.
abstract: Hearts from alpha1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody-based regimen. The elimination of the galactose-alpha1,3-galactose epitope prevented hyperacute rejection and extended survival of pig hearts in baboons for 2-6 months (median, 78 d); the predominant lesion associated with graft failure was a thrombotic microangiopathy, with resulting ischemic injury. There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies.
authors.affiliation: Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, MGH-East, 13th Street, Boston, Massachusetts 02129, USA.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kuwaki
authors.forename: Yau-Lin
authors.initials: YL
authors.lastname: Tseng
authors.forename: Frank J M F
authors.initials: FJ
authors.lastname: Dor
authors.forename: Akira
authors.initials: A
authors.lastname: Shimizu
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Houser
authors.forename: Todd M
authors.initials: TM
authors.lastname: Sanderson
authors.forename: Courtney J
authors.initials: CJ
authors.lastname: Lancos
authors.forename: Derek D
authors.initials: DD
authors.lastname: Prabharasuth
authors.forename: Jane
authors.initials: J
authors.lastname: Cheng
authors.forename: Kathleen
authors.initials: K
authors.lastname: Moran
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Hisashi
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mueller
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamada
authors.forename: Julia L
authors.initials: JL
authors.lastname: Greenstein
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hawley
authors.forename: Clive
authors.initials: C
authors.lastname: Patience
authors.forename: Michel
authors.initials: M
authors.lastname: Awwad
authors.forename: Jay A
authors.initials: JA
authors.lastname: Fishman
authors.forename: Simon C
authors.initials: SC
authors.lastname: Robson
authors.forename: Henk-Jan
authors.initials: HJ
authors.lastname: Schuurman
authors.forename: David H
authors.initials: DH
authors.lastname: Sachs
authors.forename: David K C
authors.initials: DK
authors.lastname: Cooper
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004187:Disaccharides / Q000276:immunology* / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D005700:Galactosyltransferases / Q000235:genetics* / Q000378:metabolism; D016027:Heart Transplantation; D009206:Myocardium / Q000473:pathology; D010215:Papio; D013552:Swine; D014183:Transplantation, Heterologous / Q000276:immunology
chemical_list: D004187:Disaccharides; C055075:galactosyl-(1-3)galactose; D005700:Galactosyltransferases