title: Transbilayer distribution of aminophospholipids and the oxidative stability of their component polyunsaturated fatty acids.
abstract: We examined the relationship between the transbilayer distribution of aminophospholipids, such as phosphatidylethanolamine (PE), PE plasmalogen and phosphatidylserine, and the oxidative stability of polyunsaturated fatty acids (PUFAs) in the aminophospholipids. To modulate the transbilayer distribution of aminophospholipid in liposomes, we used phosphatidylcholine (PC) with two types of acyl chain region: dipalmitoyl (PC16:0) or dioleoyl (PC18:1). In the smaller-sized liposomes, the proportions of aminophospholipid in the liposomal external layer were significantly higher in liposomes containing PC18:1 than in those containing PC16:0. Additionally, aminophospholipids in the external layer of smaller-sized liposomes were able to protect their component PUFAs from 2,2'-azobis(2-amidinopropane)dihydrochloride-mediated lipid peroxidation.
authors.affiliation: Division of Food Science, Department of Food Science Research for Health, Incorporated Administrative Agency, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan. kkubo@nih.go.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kubo
authors.forename: Seiji
authors.initials: S
authors.lastname: Sekine
authors.forename: Morio
authors.initials: M
authors.lastname: Saito
mesh_terms: D000588:Amines / Q000032:analysis; D004355:Drug Stability; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry*; D015227:Lipid Peroxidation; D008081:Liposomes; D010084:Oxidation-Reduction; D010713:Phosphatidylcholines / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010718:Phosphatidylserines / Q000737:chemistry; D010743:Phospholipids / Q000032:analysis*; D010955:Plasmalogens / Q000737:chemistry
chemical_list: D000588:Amines; D005231:Fatty Acids, Unsaturated; D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D010743:Phospholipids; D010955:Plasmalogens