title: Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activity.
abstract: Two new furo-1,2-naphthoquinones, crataequinones A (1) and B (2), were isolated from the fruits of Crataegus pinnatifida. The structures of two new compounds were determined as 11,12-dimethoxy-3,4-furo-1,2-naphthoquinone (1) and 11,12-dimethoxy-5-hydroxy-3,4-furo-1,2-naphthoquinone (2) by spectroscopic analysis. The two compounds 1 and 2 showed significant inhibitory activity with IC50 values of 33 and 90 microM, respectively, against the expression of intercellular adhesion molecule-1 (ICAM-1).
authors.affiliation: Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
authors.forename: Byung-Sun
authors.initials: BS
authors.lastname: Min
authors.forename: Ha-Thi-Thanh
authors.initials: HT
authors.lastname: Huong
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyun-Ju
authors.initials: HJ
authors.lastname: Jun
authors.forename: Min-Kyun
authors.initials: MK
authors.lastname: Na
authors.forename: Nguyen-Hai
authors.initials: NH
authors.lastname: Nam
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: KiHwan
authors.initials: K
authors.lastname: Bae
authors.forename: Sam-Sik
authors.initials: SS
authors.lastname: Kang
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D027825:Crataegus; D005638:Fruit; D006801:Humans; D020128:Inhibitory Concentration 50; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects*; D051379:Mice; D009285:Naphthoquinones / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000911:Antibodies, Monoclonal; D009285:Naphthoquinones; D010936:Plant Extracts; D018799:Intercellular Adhesion Molecule-1