title: Proliferating activity in the epithelial and stromal component of fibroadenomas and phyllodes tumours of the breast.
abstract: The aim of the study was an evaluation of PCNA and Ki-67 expression in the epithelial and stromal component of fibroepithelial tumours (FT) of the breast in correlation with morphological parameters. A series of 11 fibroadenomas (FA), including 8 cases of the cellular type (FAC), 19 benign phyllodes tumours (PTLGM), 8 bordeline (PTBM) and 6 malignant phyllodes tumours were assessed, using immunohistochemistry. The expressions of Ki-67 and PCNA in the epithelial component were significantly higher in PTLGM, when compared with FA and PTBM. A significant increase of Ki-67 and PCNA stromal expressions was associated with the progression from PTLGM to PTHGM. Our results show that Ki-67 and PCNA may be useful in the evaluation of stromal proliferation in phyllodes tumours (PT), which play an integral part in the progression from PTLGM through PTBM to PTHGM.
authors.affiliation: Department of Pathology Medical University of Białystok, Poland. joasia@zpkamb.edu.pl
authors.forename: M
authors.initials: M
authors.lastname: Barwijuk-Machała
authors.forename: J
authors.initials: J
authors.lastname: Reszeć
authors.forename: M
authors.initials: M
authors.lastname: Baltaziak
authors.forename: B
authors.initials: B
authors.lastname: Musiatowicz
authors.forename: J
authors.initials: J
authors.lastname: Cylwik
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D018226:Fibroadenoma / Q000473:pathology*; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D003557:Phyllodes Tumor / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D017154:Stromal Cells / Q000473:pathology*
chemical_list: D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen