History of depression as a predictor of adverse outcomes in patients hospitalized for decompensated heart failure.
OBJECTIVE
To evaluate the prevalence and impact of depression on the risk of in-hospital death or need for cardiopulmonary resuscitation (CPR) in patients admitted for decompensated heart failure.


METHODS
Observational single-center study.


METHODS
Coronary care unit and cardiac intermediate-care unit of a tertiary referral center.


METHODS
One hundred seventy-one patients hospitalized with decompensated heart failure who were included in the Acute Decompensated Heart Failure Registry (ADHERE).


RESULTS
The 34 patients with a history of depression had a higher likelihood of experiencing the combined end point of in-hospital death or CPR compared with the 137 patients without a history of depression (17.7% vs 6.6%, p<0.05). A history of depression (odds ratio 3.3, 95% confidence interval 1.01-10.6, p<0.05) was still predictive of in-hospital death or CPR in a multivariate analysis after adjusting for predictors of the combined end point.


CONCLUSIONS
This study suggests that a history of depression is associated with an increased risk of in-hospital mortality or CPR in patients hospitalized for decompensated heart failure. Our results require confirmation in larger trials.
de Denus
Simon
S
Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Spinler
Sarah A
SA
Jessup
Mariell
M
Kao
Andrew
A
D000928:Antidepressive Agents / Q000627:therapeutic use; D016887:Cardiopulmonary Resuscitation / Q000639:trends*; D015331:Cohort Studies; D003863:Depression / Q000150:complications / Q000401:mortality / Q000523:psychology; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000401:mortality / Q000523:psychology; D006746:Hospital Bed Capacity, 500 and over; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000928:Antidepressive Agents