Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease.
The authors report a patient with Alzheimer disease (AD) without encephalitis who was immunized with AN-1792 (an adjuvanted formulation of Abeta-42). There were no amyloid plaques in the frontal cortex and abundant Abeta-immunoreactive macrophages, but tangles and amyloid angiopathy were present. The white matter appeared normal and minimal lymphocytic infiltration in the leptomeninges was observed. This case illustrates the effects of an Abeta-based immunization on AD pathogenesis in the absence of overt meningoencephalitis and leukoencephalopathy.
Masliah
E
E
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0624, USA. emasliah@UCSD.edu
Hansen
L
L
Adame
A
A
Crews
L
L
Bard
F
F
Lee
C
C
Seubert
P
P
Games
D
D
Kirby
L
L
Schenk
D
D
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology / Q000517:prevention & control*; D023582:Alzheimer Vaccines / Q000627:therapeutic use; D016229:Amyloid beta-Peptides / Q000627:therapeutic use*; D001344:Autopsy; D001921:Brain / Q000473:pathology; D004660:Encephalitis / Q000473:pathology; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000627:therapeutic use; D014611:Vaccination / Q000009:adverse effects / Q000379:methods*
C437846:AN-1792; D023582:Alzheimer Vaccines; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C500437:amyloid beta-peptide (5-42); C086839:amyloid beta-protein (17-42)