title: Pulmonary adenocarcinomas associated with rheumatoid nodules: a case report and review of the literature.
abstract: Necrobiotic lung nodules and primary lung carcinoma both occur with some frequency in patients with rheumatoid arthritis; however, few reports exist of a primary lung carcinoma occurring within a rheumatoid nodule. We report a case of a 62-year-old woman with multiple pulmonary nodules discovered incidentally by computed tomography. Although 2 of the lesions were composed solely of necrotizing granulomas, 2 additional lesions contained malignant glands at the periphery of necrobiotic nodules. Immunohistochemical staining supported the diagnosis of both tumors as primary lung carcinomas. Our literature search revealed only 2 other reported cases of adenocarcinoma occurring in association with a rheumatoid nodule; these cases, as well as the association between rheumatoid disease and malignancy, are briefly reviewed.
authors.affiliation: Department of Pathology, University of Arizona Health Sciences Center, Tucson 85724-5108, USA. amybaruch@aol.com
authors.forename: Amy C
authors.initials: AC
authors.lastname: Baruch
authors.forename: Karen
authors.initials: K
authors.lastname: Steinbronn
authors.forename: Richard
authors.initials: R
authors.lastname: Sobonya
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications*; D008175:Lung Neoplasms / Q000209:etiology*; D008875:Middle Aged; D012218:Rheumatoid Nodule / Q000150:complications*