Bioactive compounds from the seeds of Punica granatum (pomegranate).
Two new compounds, coniferyl 9-O-[beta-D-apiofuranosyl(1-->6)]-O-beta-D-glucopyranoside (1) and sinapyl 9-O-[beta-d-apiofuranosyl(1-->6)]-O-beta-D-glucopyranoside (2), were isolated from the seeds of Punica granatum (pomegranate), together with five known compounds, 3,3'-di-O-methylellagic acid (3), 3,3',4'-tri-O-methylellagic acid (4), phenethyl rutinoside, icariside D1, and daucosterol. The structures of 1 and 2 were elucidated by spectroscopic data analysis. Compounds 1-4 exhibited antioxidant activity, which was evaluated by measurement of low-density lipoprotein (LDL) susceptibility to oxidation and by determination in vitro of malondialdehyde (MDA) levels in the rat brain.
Wang
Ru-Feng
RF
Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, People's Republic of China.
Xie
Wei-Dong
WD
Zhang
Zhang
Z
Xing
Dong-Ming
DM
Ding
Yi
Y
Wang
Wei
W
Ma
Chao
C
Du
Li-Jun
LJ
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001921:Brain; D002681:China; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000032:analysis*; D029561:Lythraceae / Q000737:chemistry*; D008315:Malondialdehyde / Q000032:analysis; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012639:Seeds / Q000737:chemistry; D013237:Stereoisomerism
D000975:Antioxidants; D005960:Glucosides; D008077:Lipoproteins, LDL; C497295:coniferyl 9-O-(beta-D-apiofuranosyl(1-6))-O-beta-D-glucopyranoside; C497296:sinapyl 9-O-(beta-D-apiofuranosyl(1-6))-O-beta-D-glucopyranoside; D008315:Malondialdehyde