title: Morphological differences of intraneuronal ubiquitin-positive inclusions in the dentate gyrus and parahippocampal gyrus of motor neuron disease with dementia.
abstract: Semiquantitative morphological analysis of cerebral intraneuronal ubiquitin-positive tau-negative inclusions, a pathologic marker for motor neuron disease with dementia (MND-D), was performed in the dentate gyrus and parahippocampal gyrus of 20 clinicopathologically confirmed patients with MND-D. The forms of the inclusions were tentatively classified into three types: (i) C-type, consisting of relatively large and intensely stained crescent or circular structures; (ii) L-type, showing fine linear structures around the nuclei; and (iii) G-type, showing faintly stained granular structures. The frequencies of the C-type, L-type and G-type was 0.5-9.3%,0.2-6.5% and 0-6.6% of dentate granule cells, respectively. In contrast to the dentate gyrus, almost all inclusions showed either the C-type or L-type form in the parahippocampal gyrus. A positive correlation was noted only between incidences of C-type inclusion of the dentate gyrus and that of the parahippocampal gyrus (r = 0.69, P < 0.05). The morphological differences of the inclusions probably reflect different stages of their formation.
authors.affiliation: Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. myaguchi@med.gunma-u.ac.jp
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Yaguchi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Fujita
authors.forename: Masakuni
authors.initials: M
authors.lastname: Amari
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Takatama
authors.forename: Safa
authors.initials: S
authors.lastname: Al-Sarraj
authors.forename: Peter N
authors.initials: PN
authors.lastname: Leigh
authors.forename: Koichi
authors.initials: K
authors.lastname: Okamoto
mesh_terms: D000328:Adult; D000368:Aged; D003704:Dementia / Q000378:metabolism / Q000473:pathology*; D018891:Dentate Gyrus / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000737:chemistry*; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000378:metabolism / Q000473:pathology*; D009474:Neurons / Q000737:chemistry; D020534:Parahippocampal Gyrus / Q000737:chemistry / Q000473:pathology*; D025801:Ubiquitin / Q000032:analysis* / Q000096:biosynthesis
chemical_list: D025801:Ubiquitin