title: Physiological (osmotic fragility) and morphological effects on red blood cells: action of phytic acid and stannous fluoride.
abstract: Phytic acid occurs in foods derived from plants. We have investigated the possibility that phytic acid and stannous fluoride are capable of altering the physiological properties (osmotic fragility) and morphological properties of red blood cells (RBC). Osmotic fragility was unchanged by the presence of phytic acid and stannous fluoride in the studied concentrations, but RBC morphology was modified in the presence of the studied substances. In conclusion, the alterations to RBC morphology were not sufficient to promote modifications in osmotic fragility. Our results suggest that the chelating properties of phytic acid could be responsible for the observed effects.
authors.affiliation: Department of Biophysics, Roberto Alcântara Gomes Institute of Biology, State University of Rio de Janeiro, 87 Avenida 28 de Setembro, Rio de Janeiro 20551-030, Brazil. gllf@click21.com.br
authors.forename: Guilherme L
authors.initials: GL
authors.lastname: Lima-Filho
authors.forename: Glaydes M T
authors.initials: GM
authors.lastname: Lima
authors.forename: Silvana R F
authors.initials: SR
authors.lastname: Moreno
authors.forename: Luiz C M
authors.initials: LC
authors.lastname: Aleixo
authors.forename: Sebastião D
authors.initials: SD
authors.lastname: Santos-Filho
authors.forename: Rosimeire S
authors.initials: RS
authors.lastname: Freitas
authors.forename: Vilma G B
authors.initials: VG
authors.lastname: Melo
authors.forename: Mario
authors.initials: M
authors.lastname: Bernardo-Filho
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000187:drug effects* / Q000648:ultrastructure*; D066298:In Vitro Techniques; D009996:Osmotic Fragility; D010833:Phytic Acid / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000494:pharmacology; D014002:Tin Fluorides / Q000494:pharmacology*
chemical_list: D014002:Tin Fluorides; D012965:Sodium Chloride; D010833:Phytic Acid