[The pathophysiology of obesity].
Obesity is a multi-cause syndrome. Overfeeding and low exercise produces excess of body fat. There are individual and population differences in energy balance, (ethnical, diet behavior, longer life expectancies). Genetic factors may influence the setting of obesity, but the calorie intake, physical activity, and lifestyle are critical determinants. As a consequence of the complex mechanisms involved in the pathogenesis of this syndrome and its complications, each model used in the diagnostic and therapeutic approach are partial. New evidences on the genetic and neuroendocrine factors in obesity are emerging, however, a holistic model is needed to understand this syndrome where biologic, psychological and social factors act together in a very intricate way. Using this model, better understanding in prevention and treatment is expected.
Hernández-Jiménez
Sergio
S
Departamento de Endocrinología y metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirin, Vasco de Quiroga 15 Sección XVI Tlalpan C.P. 14000, México, DF. sergiohdz@hotmail.com
D004777:Environment; D006801:Humans; D009765:Obesity / Q000235:genetics / Q000503:physiopathology*