Investigation of possible cytokine induction in peripheral blood mononuclear cells by heat-stable serotypes of Campylobacter jejuni.
Several Campylobacter jejuni heat-stable (HS) serotypes have been associated with the autoimmune Guillain-Barre neurological syndrome (GBS). In order to examine the possible involvement of cytokines in this phenomenon, the levels of three pro-inflammatory cytokines (interleukin (IL)-2sRa, IL-6 and interferon (IFN)-gamma) and one anti-inflammatory cytokine (IL-10) were measured in peripheral blood mononuclear cells after induction by different C. jejuni serotypes. No differences were found for IL-6, IFN-gamma and IL-10, but the non-sialylated serotype HS:3 was associated with decreased production of IL-2sRa. The results raise the possibility that absence of sialylation might be associated with the inability to induce inflammatory factors such as cytokines.
Chatzipanagiotou
S
S
Athens Medical School, Department of Clinical Microbiology, Aeginition Hospital, Athens, Greece. schatzi@med.uoa.gr
Michalopoulou
M
M
Marinou
I
I
Boufidou
F
F
Papavasileiou
E
E
Trikka-Graphakos
E
E
Kabouri
E
E
Nicolaou
C
C
Legakis
N J
NJ
D015551:Autoimmunity; D002169:Campylobacter Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D016123:Campylobacter jejuni / Q000145:classification* / Q000276:immunology* / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis*; D015536:Down-Regulation; D020275:Guillain-Barre Syndrome / Q000276:immunology / Q000382:microbiology*; D006358:Hot Temperature; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D012703:Serotyping; D012995:Solubility
D016207:Cytokines; D015375:Receptors, Interleukin-2