title: Synthesis and activity of 2-oxoamides containing long chain beta-amino acids.
abstract: 2-Oxoamides based on long chain beta-amino acids were synthesized. 1-Benzyl substituted long chain amines, needed for such synthesis, were synthesized starting from Boc-phenylalaninol. The oxidative conversion of a phenyl group to a carboxyl group was used as the key transformation synthetic step. The compounds synthesized were studied for their activity against GIVA PLA(2), and were proven to be weak inhibitors.
authors.affiliation: Chemical Laboratories, Agricultural University of Athens, Iera Odos 75, Athens 11855, Greece.
authors.forename: Violetta
authors.initials: V
authors.lastname: Constantinou-Kokotou
authors.forename: Anna
authors.initials: A
authors.lastname: Peristeraki
authors.forename: Christoforos G
authors.initials: CG
authors.lastname: Kokotos
authors.forename: David A
authors.initials: DA
authors.lastname: Six
authors.forename: Edward A
authors.initials: EA
authors.lastname: Dennis
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D005563:Formic Acid Esters / Q000378:metabolism; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D011725:Pyridines / Q000138:chemical synthesis*
chemical_list: D000596:Amino Acids; D005563:Formic Acid Esters; D011725:Pyridines; C000345:t-butyloxycarbonyl group; C012481:phenylalaninol; D010649:Phenylalanine; C034960:oxoamide; D010741:Phospholipases A