The effect of coenzyme Q10 and vitamin E on the regeneration of skeletal muscles in pigs.
The aim of the study was to observe the effect of coenzyme Q10 and vitamin E supplementation on the course of the regeneration process of the longissimus lumborum muscle after bupivacaine-induced myonecrosis as well as to determine the correlation between the level of those substances in plasma and their levels in damaged and non-damaged muscular tissue in pigs. The obtained results indicate that the course of regeneration of a damaged muscle is affected to a higher extent by coenzyme Q10 than by vitamin E. The administration of coenzyme Q10 and vitamin E has a significant impact on the increase in the level of those substances in damaged muscles and plasma of animals.
Otrocka-Domagała
I
I
Department of Pathology and Pharmacology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland.
Rotkiewicz
T
T
Karpińska
J
J
Purzyńska-Pugacewicz
A
A
Kasperowicz
B
B
Mikołajczyk
A
A
Babińska
I
I
D000779:Anesthetics, Local / Q000633:toxicity; D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism; D002045:Bupivacaine / Q000633:toxicity; D003067:Coenzymes; D005260:Female; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D009135:Muscular Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary*; D009336:Necrosis; D012038:Regeneration / Q000502:physiology*; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced / Q000503:physiopathology*; D014451:Ubiquinone / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood
D000779:Anesthetics, Local; D000975:Antioxidants; D003067:Coenzymes; D014451:Ubiquinone; D014810:Vitamin E; C024989:coenzyme Q10; D002045:Bupivacaine