Aberrant expression of platelet-derived growth factor (PDGF) and PDGF receptor-alpha is associated with advanced bone marrow fibrosis in idiopathic myelofibrosis.
The expression of members of the platelet-derived growth factor (PDGF) system in bone marrow cells derived from Idiopathic myelofibrosis (IMF) has been investigated by real-time RT-PCR. Increased expression of PDGFs and the corresponding PDGF receptor a could be demonstrated to be a feature of advanced fibrosis in IMF that is not demonstrable in the prefibrotic phase of the disease.
Bock
Oliver
O
Loch
Gero
G
Büsche
Guntram
G
von Wasielewski
Reinhard
R
Schlué
Jerome
J
Kreipe
Hans
H
D018450:Disease Progression; D015870:Gene Expression; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000737:chemistry / Q000235:genetics*; D055728:Primary Myelofibrosis / Q000235:genetics*; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000737:chemistry / Q000235:genetics*
D010982:Platelet-Derived Growth Factor; D020033:Protein Isoforms; D020796:Receptor, Platelet-Derived Growth Factor alpha