title: Bronchial hyperresponsiveness in patients with sarcoidosis.
abstract: OBJECTIVE
  To study bronchial hyperresponsiveness (BHR) in patients with sarcoidosis.
  
  
  METHODS
  Twenty freshly diagnosed patients with sarcoidosis were evaluated. Progressively increasing concentrations of methacholine were administered using a standard five-breath dosimeter protocol, and spirometry performed after each challenge. BHR was expressed as PC20 (provocating concentration of methacholine resulting in 20% fall in forced expiratory volume in first second). All patients were nonsmokers, had no other concurrent cardiopulmonary disease, and were not on any specific treatment for sarcoidosis.
  
  
  RESULTS
  Borderline (PC20 4.0-16.0 mg/mL), mild (PC20 1.0-4.0 mg/mL) and moderate to severe (PC20 <1.0 mg/mL) BHR was documented in three (15%), one (5%) and five (25%) patients respectively. Patients with BHR were similar to those having normal reactivity in terms of age, gender, disease duration and results of pulmonary function testing. All patients with endobronchial disease had BHR.
  
  
  CONCLUSIONS
  BHR may be seen in several patients of sarcoidosis and could possibly contribute to decline in lung function.
authors.affiliation: Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research Chandigarh, India.
authors.forename: A N
authors.initials: AN
authors.lastname: Aggarwal
authors.forename: D
authors.initials: D
authors.lastname: Gupta
authors.forename: G
authors.initials: G
authors.lastname: Chandrasekhar
authors.forename: S K
authors.initials: SK
authors.lastname: Jindal
mesh_terms: D000328:Adult; D016535:Bronchial Hyperreactivity / Q000145:classification / Q000150:complications* / Q000175:diagnosis; D001985:Bronchial Provocation Tests; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D016210:Methacholine Chloride; D017565:Sarcoidosis, Pulmonary / Q000150:complications*; D012720:Severity of Illness Index; D013147:Spirometry
chemical_list: D016210:Methacholine Chloride