title: Imatinib-responsive hypereosinophilia in a patient with B cell ALL.
abstract: Hypereosinophilia is a rare presenting sign of acute lymphocytic leukemia. A 29-year-old male was diagnosed with idiopathic hypereosinophilic syndrome with respiratory symptoms. Although his peripheral blood eosinophilia decreased in response to treatment with imatinib mesylate, a follow-up bone marrow showed a diffuse infiltrate of myeloperoxidase-negative blasts. He was subsequently diagnosed with CD10 positive precursor B lymphoblastic leukemia. This case underscores the importance of follow-up bone marrow examination in patients who demonstrate imatinib mesylate-responsive eosinophilia.
authors.affiliation: Hematology Branch, National Heart Lung and Blood Institute National Institutes of Health Bethesda, MD 20892, USA. robynj@nih.gov
authors.forename: Jamie
authors.initials: J
authors.lastname: Robyn
authors.forename: Pierre
authors.initials: P
authors.lastname: Noel
authors.forename: Iwona
authors.initials: I
authors.lastname: Wlodarska
authors.forename: Mamta
authors.initials: M
authors.lastname: Choksi
authors.forename: Patricia
authors.initials: P
authors.lastname: O'neal
authors.forename: Diane
authors.initials: D
authors.lastname: Arthur
authors.forename: Cynthia
authors.initials: C
authors.lastname: Dunbar
authors.forename: Thomas
authors.initials: T
authors.lastname: Nutman
authors.forename: Amy
authors.initials: A
authors.lastname: Klion
mesh_terms: D000328:Adult; D001549:Benzamides; D002051:Burkitt Lymphoma / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D000068877:Imatinib Mesylate; D007958:Leukocyte Count; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate