[Antibodies against citrullinated proteins--a breakthrough in rheumatologic diagnostics].
Antibodies directed against citrullinated proteins (anti-CP) constitute a newly defined group of autoantibodies with very high diagnostic specificity for rheumatoid arthritis (RA). The most recently developed assays have a sensitivity comparable to that of traditional tests for Rheumatoid Factor (RF). Due to its considerably higher specificity, the authors recommend that anti-CP antibody analysis should replace the RF test in primary healthcare when investigating cases of clinically suspect RA.
Rönnelid
Johan
J
Enheten för klinisk immunologi, klinisk immunologi och transfusionsmedicin, Uppsala universitet/Akademiska sjukhuset. johan.ronnelid@klinimm.uu.se
Klareskog
Lars
L
Skogh
Thomas
T
Svensson
Björn
B
D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D002956:Citrulline / Q000276:immunology*; D006801:Humans; D011379:Prognosis; D012217:Rheumatoid Factor / Q000097:blood; D012680:Sensitivity and Specificity
D001323:Autoantibodies; D002956:Citrulline; D012217:Rheumatoid Factor