title: Three-week clinical trial of a 14% hydrogen-peroxide, strip-based bleaching system.
abstract: This clinical trial tested the efficacy and safety of a professional strip-based whitening system (Crest Whitestrips Supreme) using the manufacturer's recommended 3-week treatment regimen. These strips have a higher concentration, but a similar amount of hydrogen peroxide relative to Crest Professional Whitestrips, because the thickness of the gel on strips is reduced. Tooth whitening was measured using the value-oriented VITA Classic Shade Guide before and after treatment. Twenty-nine subjects were treated with either Crest Whitestrips Supreme or placebo strips that did not contain hydrogen peroxide. Participants in the experimental group achieved a mean lightening of nearly eight VITA shades relative to placebo, with minimal side effects.
authors.affiliation: Department of Operative Dentistry, University of North Carolina, Chapel Hill, North Carolina, USA.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Swift
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Miguez
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Barker
authors.forename: Robert W
authors.initials: RW
authors.lastname: Gerlach
mesh_terms: D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D016503:Drug Delivery Systems; D005260:Female; D005500:Follow-Up Studies; D005782:Gels / Q000008:administration & dosage*; D005881:Gingiva / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008437:Maxilla; D008875:Middle Aged; D016877:Oxidants / Q000008:administration & dosage* / Q000009:adverse effects; D014073:Tooth Bleaching / Q000009:adverse effects / Q000379:methods*; D014075:Tooth Discoloration / Q000188:drug therapy*; D014098:Toothache / Q000139:chemically induced; D016896:Treatment Outcome
chemical_list: C488279:Crest whitestrips; D005782:Gels; D016877:Oxidants; D006861:Hydrogen Peroxide