Effect of different dose schedules of 0.15% unoprostone isopropyl on intraocular pressure and pupil size in the glaucomatous beagle.
The changes in intraocular pressure (IOP) and pupil size (PS) after instillations of 0.15% unoprostone isopropyl (Rescula, Novartis Ophthalmics, Duluth, GA) were investigated in the spontaneous glaucoma Beagle model. From the first-day baseline IOP of 27.3+/-3.2 mmHg placebo eye and 32.8+/-5.1 mmHg control eye, the mean+/-standard error of the mean (SEM) diurnal changes after 0.15% unoprostone, at 8 AM once-daily for the next 4 days, were 15.5+/-1.3 mmHg, 14.7+/-1.9 mmHg, 16.1+/-1.1 mmHg, and 17.0+/-1.5 mmHg, respectively, and were significantly different from the control eye. After 0.15% unoprostone was instilled at 8 PM, the mean+/-SEM baseline changes from the baseline IOP (insert drug eye 9 AM) in the drug eyes were 5.9+/-2.5 mmHg, 5.2+/-4.1 mmHg, 9.7+/-2.5 mmHg, and 3.6+/-3.6 mmHg, respectively. When 0.15% unoprostone was instilled twice-daily, the mean+/-SEM baseline IOP (insert drug eye 9 AM) changes were 13.6+/-0.7 mmHg, 13.9+/-1.4 mmHg, 11.3+/-1.0 mmHg, and 9.3+/-1.4 mmHg, respectively, and were significantly different from the control eyes. Miosis occurred within 2 hours and lasted several hours. Unoprostone isopropyl instilled once-daily (AM or PM), as well as twice-daily, produces significant decreases in IOP and PS in the glaucomatous Beagle.
Gelatt
Kirk N
KN
Department of Small Animal Clinical Sciences and Gwathmey-Adams Laboratory for Vision Science, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610-0126, USA. gelattk@mail.vetmed.ufl.edu
Mackay
Edward O
EO
Dashiell
Thomas
T
Biken
Alison
A
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D015237:Dinoprost / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004334:Drug Administration Schedule; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000662:veterinary*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011680:Pupil / Q000187:drug effects*; D014065:Tonometry, Ocular / Q000662:veterinary
D000959:Antihypertensive Agents; C072630:isopropyl unoprostone; D015237:Dinoprost