title: Persistence of Kaposi sarcoma-associated herpesvirus (KSHV)-infected cells in KSHV/HIV-1-coinfected subjects without KSHV-associated diseases.
abstract: Inguinal lymph nodes from 24 human immunodeficiency virus (HIV) type 1-infected subjects without Kaposi sarcoma-associated herpesvirus (KSHV)-associated diseases were examined for KSHV infection. KSHV-infected cells were detected at a very low frequency in the lymph nodes of 7 subjects (median frequency, 2 infected cells/10(7) lymph node cells). Latent, but not lytic, KSHV gene expression was detected and KSHV-infected cells were located in B cell-rich areas of lymph node follicles. These findings provide evidence that, in the absence of KSHV-associated diseases, latent infection of lymph node cells provides a mechanism for the persistence of KSHV in KSHV/HIV-1-coinfected persons.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. thomas.campbell@uchsc.edu.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Campbell
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Staskus
authors.forename: Joy
authors.initials: J
authors.lastname: Folkvord
authors.forename: Irene E
authors.initials: IE
authors.lastname: White
authors.forename: James
authors.initials: J
authors.lastname: Neid
authors.forename: Xing-Quan
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Connick
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000821:virology*; D004197:Disease Reservoirs; D005260:Female; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1 / Q000502:physiology; D019288:Herpesvirus 8, Human / Q000502:physiology*; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000821:virology; D017735:Virus Latency