title: Kinases regulating Golgi apparatus structure and function.
abstract: Protein kinases control Golgi function in both mitotic and interphase cells. In mitosis, phosphorylation of structural proteins by Cdk1 (cyclin-dependent kinase 1)-cyclin B, Polo-like and mitogen-activated protein kinases underlie changes in Golgi reorganization during cell division. While in interphase, signalling pathways that are associated with the Golgi control secretory function through a variety of mechanisms. Some of these, notably those involving protein kinase D and Ste20 family kinases, are also relevant for the establishment and maintenance of cell polarization and migration.
authors.affiliation: Max-Planck Institute of Biochemistry, Am Klopferspitz 18, Martinsried 82152, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Preisinger
authors.forename: Francis A
authors.initials: FA
authors.lastname: Barr
mesh_terms: D000818:Animals; D002465:Cell Movement; D016764:Cell Polarity; D006056:Golgi Apparatus / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D007399:Interphase; D008938:Mitosis; D011494:Protein Kinases / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D011494:Protein Kinases