title: Linkage disequilibrium analysis in the LOC93081-KDELC1-BIVM region on 13q in bipolar disorder.
abstract: Genome-wide scans in bipolar disorder and a meta analysis on published data have provided evidence for linkage to chromosome 13q, although the reported peaks from various studies have not converged in a narrow region. Recently, single nucleotide polymorphisms (SNPs) at the G72/G30 locus have been shown to be associated with bipolar disorder suggesting its potential role in increasing disease risk. The proposed linkage region on 13q extends over a wide span, and could provide a clue to the existence of other susceptibility variants. In the present study, SNPs in the LOC93081-KDELC1-BIVM, a region proximal to G72, were interrogated in two bipolar family series. KDELC1 has a predicted filamin domain and BIVM contains an immunoglobulin-like motif. The small pedigree series yielded a nominally significant global P-value due to under-transmission of a rare haplotype but this finding was not supported by results from the larger series and in the case-control study that compared 278 cases and 277 controls.
authors.affiliation: Genetic Basis for Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA.
authors.forename: Dilberto O
authors.initials: DO
authors.lastname: Ferraren
authors.forename: Chunyu
authors.initials: C
authors.lastname: Liu
authors.forename: Judith A
authors.initials: JA
authors.lastname: Badner
authors.forename: Winston
authors.initials: W
authors.lastname: Corona
authors.forename: Azadeh
authors.initials: A
authors.lastname: Rezvani
authors.forename: Virginia D
authors.initials: VD
authors.lastname: Monje
authors.forename: Elliot S
authors.initials: ES
authors.lastname: Gershon
authors.forename: Tom I
authors.initials: TI
authors.lastname: Bonner
authors.forename: Sevilla D
authors.initials: SD
authors.lastname: Detera-Wadleigh
mesh_terms: D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D003285:Contractile Proteins / Q000235:genetics; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004252:DNA Mutational Analysis; D005192:Family Health; D005260:Female; D064448:Filamins; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008840:Microfilament Proteins / Q000235:genetics; D018895:Microsatellite Repeats; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide
chemical_list: D003285:Contractile Proteins; D064448:Filamins; D007136:Immunoglobulins; D008840:Microfilament Proteins; D004247:DNA