Subcellular localization and trafficking of kainate receptors.
Glutamate receptors of the kainate type have been identified recently as key players in the modulation of neuronal-network activity. The role of kainate receptors depends on their precise subcellular localization in presynaptic, postsynaptic and extrasynaptic domains. Subcellular localization of kainate receptors has been inferred mainly from electrophysiological studies with the help of selective pharmacological tools and kainate receptor mutant mice. These studies, combined with recent ultrastructural data, highlight the diversity of subcellular localizations of kainate receptors. It is important to understand the molecular mechanisms that underlie the polarized trafficking of kainate receptors in distinct neuronal domains. In this article, we review recent data that shed light on the trafficking and membrane delivery of kainate receptor isoforms, and on the identification of proteins that interact with kainate receptors and might regulate this trafficking.
Jaskolski
Frédéric
F
Laboratoire 'Physiologie Cellulaire de la Synapse', CNRS UMR 5091, Institut François Magendie, Université Bordeaux 2, rue C. Saint-Saëns, 33077 Bordeaux Cedex, France.
Coussen
Françoise
F
Mulle
Christophe
C
D000818:Animals; D004594:Electrophysiology / Q000379:methods; D008958:Models, Molecular; D020033:Protein Isoforms; D021381:Protein Transport / Q000502:physiology*; D018092:Kainic Acid Receptors / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure*; D013347:Subcellular Fractions / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure*
D020033:Protein Isoforms; D018092:Kainic Acid Receptors