title: Protein conformational space in higher order phi-Psi maps.
abstract: We have mapped protein conformational space from two to seven residue lengths by employing multidimensional scaling on a data matrix composed of pair-wise angular distances for multiple phi-Psi values collected from high-resolution protein structures. The resulting global maps show clustering of peptide conformations that reveals a dramatic reduction of conformational space as sampled by experimentally observed peptides. Each map can be viewed as a higher order phi-Psi plot defining regions of space that are conformationally allowed.
authors.affiliation: Biophysics Graduate Group and Department of Chemistry, University of California, Berkeley, CA 94720, USA.
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Sims
authors.forename: In-Geol
authors.initials: IG
authors.lastname: Choi
authors.forename: Sung-Hou
authors.initials: SH
authors.lastname: Kim
mesh_terms: D016000:Cluster Analysis; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
chemical_list: D010455:Peptides; D011506:Proteins