title: Constituents from the stems of Hibiscus taiwanensis.
abstract: Five new compounds, hibicuslide A (1), hibicuslide B (2), hibicuslide C (3), hibicutaiwanin (4), hibicusin (5), and fifty-one known compounds have been isolated from the stems of Hibiscus taiwanensis. The structures of these compounds were determined by spectroscopic and chemical transformation methods. Among them, mansonone H (19) and uncarinic acid A (30) inhibited HIV replication in H9 lymphocyte cells. The 9,9'-O-feruloyl-(-)-secoisolaricinresinol (12), myriceric acid C (29), and uncarinic acid A (30) showed cytotoxic activity against human lung carcinoma and breast carcinoma.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Taiwan. wupl@mail.ncku.edu.tw
authors.forename: Pei-Lin
authors.initials: PL
authors.lastname: Wu
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: He
authors.forename: Chia-Hao
authors.initials: CH
authors.lastname: Su
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D045744:Cell Line, Tumor; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D031584:Hibiscus; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000821:virology; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems
chemical_list: D010936:Plant Extracts