title: Efficacy of subantimicrobial-dose doxycycline in the treatment of periodontal diseases: a critical evaluation.
abstract: Controlled clinical trials that evaluate the benefits of adjunctive subantimicrobial-dose doxycycline (SDD) with conventional therapy were selected for review. It was deemed important to distinguish between statistically significant and clinically relevant results related to SDD use to help guide clinicians in selecting appropriate therapies. Several investigations demonstrated that SDD prescribed as an adjunct to conventional therapy provides a statistically significant improvement with respect to probing depth reduction, gain of clinical attachment, decreased bleeding on probing, and reduced incidence of disease progression in patients with chronic periodontitis. However, conflicting data were also noted in some studies. Furthermore, it is suggested that the clinical relevance of improvements obtained with SDD beyond those obtained with conventional therapy is debatable. Therefore, clinicians should interpret the data cautiously and differentiate between statistically significant and clinically relevant findings before altering treatment regimens.
authors.affiliation: Department of Periodontology, University of Medicine and Dentistry of New Jersey, Newark, USA. Ggperio@aol.com
authors.forename: Gary
authors.initials: G
authors.lastname: Greenstein
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D018849:Controlled Clinical Trials as Topic; D018450:Disease Progression; D004318:Doxycycline / Q000008:administration & dosage*; D005884:Gingival Hemorrhage / Q000188:drug therapy / Q000628:therapy; D006801:Humans; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000628:therapy; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000628:therapy; D010514:Periodontal Pocket / Q000188:drug therapy / Q000628:therapy; D010518:Periodontitis / Q000188:drug therapy / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline