title: [Detection and analysis of the sub-types of -alpha3.7 in Chinese].
abstract: -alpha3.7 is a common deletional alpha-thalassemia-2 in China. According to different recombination sites,-alpha3.7 can be divided into -alpha3.7I,-alpha3.7IIand -alpha3.7III. The frequency and population distribution of these -alpha3.7 are quite different. In this study,we detected 56 patients among Chinese population of -alpha3.7 defect in alpha globin gene by PCR method, then the PCR product was digested by the restriction enzyme ApalI and BalI. The sub-typing result shows that in the 56 cases of -alpha3.7 defect,54 out of 56 is -alpha3.7I,2 out of 56 is -alpha3.7II and none of -alpha3.7III is detected. This result enriches the data about the alpha thalassemia genotypes of Chinese people.
authors.affiliation: Department of Medical Genetics, Zhongshan Medical College, SunYat-sen University, Guangzhou 510089, China. chensuqin99@hotmail.com
authors.forename: Su-Qin
authors.initials: SQ
authors.lastname: Chen
authors.forename: Hong-Yi
authors.initials: HY
authors.lastname: Li
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chen
authors.forename: Shan
authors.initials: S
authors.lastname: Duan
authors.forename: Lu-Ming
authors.initials: LM
authors.lastname: Chen
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Tian
authors.forename: Chuan-Shu
authors.initials: CS
authors.lastname: Du