title: [Sonographic evaluation of endometrial preparation with oral estrogen-progesterone substitution before cryogenic embryo transfer].
abstract: OBJECTIVE
  To compare the changes of sonographic features of endometrium throughout natural and artificial cycles in which oral estrogen-progesterone substitution were used in the same group of patients and discuss their clinical significance.
  
  
  METHODS
  A prospective study.
  
  
  METHODS
  Dept. of Obstetrics and Gynaecology, University Hospital, Olomouc.
  
  
  METHODS
  In 24 women with regular menstrual cycle ovulation was detected (LH, sonography) and the following sonographic features: endometrial thickness, echogenity and pulsatility index (PI) of uterine artery were evaluated in the late proliferative, early and mid secretory phase. The same sonographic examination was performed in the artificial cycle with oral estrogen-progesterone substitution used for endometrial preparation for transfer of cryopreserved-thawed embryos.
  
  
  RESULTS
  In the late proliferative phase of the natural cycle the thickness of endometrium was higher than in the arteficial cycle (p=0.05). Triple-line echogenity prevailed in both cycles. The PI in natural cycle was lower (p=0.01) on the side of the growing Graafian follicle compared to the other side and lower (p=0.05) than in the artificial cycle. In the secretory phase there were no differences in endometrial thickness within cycles. Homogenous hyperechoic endometrium prevailed in both cycles and the lowest PI was found on the 7th day both after ovulation and after initiation of progesterone substitution.
  
  
  CONCLUSIONS
  Progesterone addition after endometrial preparation with estrogen should be instituted when the endometrium thickness reached at least 9mm and isoechoic or triple line echogenity is found.
authors.affiliation: Gynekologicko-porodnická klinika LF UP a FN, Olomouc.
authors.forename: I
authors.initials: I
authors.lastname: Oborná
authors.forename: J
authors.initials: J
authors.lastname: Dostál
authors.forename: J
authors.initials: J
authors.lastname: Brezinová
authors.forename: M
authors.initials: M
authors.lastname: Svobodová
authors.forename: H
authors.initials: H
authors.lastname: Fingerová
mesh_terms: D000284:Administration, Oral; D000328:Adult; D015925:Cryopreservation; D004624:Embryo Transfer; D004717:Endometrium / Q000000981:diagnostic imaging* / Q000187:drug effects*; D004958:Estradiol / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008597:Menstrual Cycle; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage*; D011673:Pulsatile Flow; D018608:Ultrasonography, Doppler; D014599:Uterus / Q000098:blood supply
chemical_list: D004966:Estrogens, Conjugated (USP); D011374:Progesterone; D004958:Estradiol