Dermal fibrosis and cutaneous necrosis after recombinant interferon-beta1a injection in a multiple sclerosis patient.
The most commonly reported side-effects of recombinant interferon-beta1a and 1b include local inflammatory injection site reactions, headache, fever, myalgia and a flu-like syndrome. In this case report, we describe the occurrence of cutaneous necrosis and dermal fibrosis following intramuscular interferon-beta1a injections in a multiple sclerosis patient.
Ozden
M G
MG
Gazi University, Faculty of Medicine, Dermatology Department, 06100 Besevler, Ankara, Turkey.
Erel
A
A
Erdem
O
O
Oztas
M O
MO
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis / Q000209:etiology*; D006801:Humans; D007267:Injections / Q000009:adverse effects; D016899:Interferon-beta / Q000008:administration & dosage / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000188:drug therapy*; D009336:Necrosis / Q000209:etiology; D012883:Skin Ulcer / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology
D016899:Interferon-beta