The effects of mitomycin C and 5-fluorouracil/triamcinolone on fibrosis/scar tissue formation secondary to subglottic trauma (experimental study).
OBJECTIVE
The aim of the study was to compare the effects of mitomycin-C (MMC) and 5-fluorouracil/triamcinolone acetonide (5-FU/TA) on the development of fibrosis/scar tissue formation of rabbit subglottic area, which is injured acutely.


METHODS
After standardized trauma to subglottic area the rabbits were divided into those that received treatment and those that did not (controls). The subjects were treated with either topical 0.4 mg/mL MMC or 5 mg 5-FU/TA injection. Those groups were further divided into subgroups depending on the time of examination: at 2 or 6 weeks. Each subgroup had 4 rabbits. The specimens were examined histopathologically and the measurements were performed using a software.


RESULTS
The fibrosis indices (FIs) of the treated subgroups were significantly less than the FIs of their corresponding control subgroups (P<.05). The difference in FIs of the MMC-treated and 5-FU/TA-treated groups was not statistically significant (P>.05). MMC and 5-FU/TA did not interfere with regeneration of the epithelium although in 2 cases treated with 5-FU/TA the regenerated epithelium showed squamous metaplasia.


CONCLUSIONS
Both MMC and 5-FU/TA decrease fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma. There is no significant difference between the effects of the 2 drugs.
Cincik
Hakan
H
Department of ENT, Gülhane Military Medical Academy, Haydarpaşa Training Hospital, Istanbul, Turkey. hcincik@ttnet.net.tr
Gungor
Atila
A
Cakmak
Adem
A
Omeroglu
Atilla
A
Poyrazoglu
Ethem
E
Yildirim
Sukru
S
Cekin
Engin
E
Candan
Hasan
H
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002921:Cicatrix / Q000150:complications / Q000517:prevention & control*; D005355:Fibrosis; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D007829:Laryngostenosis / Q000209:etiology / Q000517:prevention & control; D007830:Larynx / Q000293:injuries* / Q000473:pathology; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D012044:Regression Analysis; D012720:Severity of Illness Index; D014135:Tracheal Stenosis / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage / Q000627:therapeutic use*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D014221:Triamcinolone; D016685:Mitomycin; D005472:Fluorouracil