title: The effect of a single administration of cephapirin or cloprostenol on the reproductive performance of dairy cows with subclinical endometritis.
abstract: This study examined the effect of a single administration of cephapirin iu or cloprostenol im on the reproductive performance of dairy cows with subclinical endometritis. Cows (n = 228) at 20-33 days in milk (DIM) from two commercial dairy farms, determined to be normal for clinical endometritis (based on absence of abnormal uterine discharge on vaginoscopic examination) were enrolled. At enrollment, a thorough reproductive examination was performed, including rectal palpation, ultrasonography (US) and endometrial cytology (EC). The case definition for subclinical endometritis was the presence of >18% neutrophils on EC examination or fluid in uterus (FIU) on US examination. All cows were randomly assigned to receive one of three treatments: 500 mg benzathine cephapirin iu, 500 microg cloprostenol im, or control (no treatment). Reproductive performance was monitored for a minimum of 8 months after treatment. Cows with subclinical endometritis treated with cephapirin or cloprostenol had a significantly increased relative pregnancy rate compared to control [hazard ratios 1.89 (P = 0.01) and 1.70 (P = 0.05), respectively]. In conclusion, a single treatment with cephapirin or cloprostenol at 20-33 DIM significantly improved the reproductive performance of cows with subclinical endometritis.
authors.affiliation: Department of Population Medicine, University of Guelph, Guelph, Ont., N1G 2W1, Canada. drram@vt.edu
authors.forename: R
authors.initials: R
authors.lastname: Kasimanickam
authors.forename: T F
authors.initials: TF
authors.lastname: Duffield
authors.forename: R A
authors.initials: RA
authors.lastname: Foster
authors.forename: C J
authors.initials: CJ
authors.lastname: Gartley
authors.forename: K E
authors.initials: KE
authors.lastname: Leslie
authors.forename: J S
authors.initials: JS
authors.lastname: Walton
authors.forename: W H
authors.initials: WH
authors.lastname: Johnson
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000503:physiopathology*; D002514:Cephapirin / Q000008:administration & dosage*; D003008:Cloprostenol / Q000008:administration & dosage*; D004716:Endometritis / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D005260:Female; D011247:Pregnancy; D012098:Reproduction
chemical_list: D000900:Anti-Bacterial Agents; D003008:Cloprostenol; D002514:Cephapirin