title: Prooxidant-antioxidant balance in blood during the surgical treatment of obliterating arterial atherosclerosis in the lower extremities.
abstract: The chronic disorder of arterial circulation in the lower extremities due to the atherosclerotic injuries of the femoral-popliteal-tibial arteries was accompanied by the shift of the blood prooxidant-antioxidant balance towards more active free radical oxidation and by a depletion of antioxidant system. After restoring arterial blood flow in the ischemic lower extremities this balance was shifted towards more prominent lipid peroxidation processes. Such pattern of prooxidant-antioxidant balance changes implicates the development of strategies for its correction targeted on the reduction of lipid peroxidation activity and therefore on a tissue defense against the reperfusion injury.
authors.affiliation: Surgical Disease Department No 1, Grodno State Medical University, Belarus.
authors.forename: N N
authors.initials: NN
authors.lastname: Ioskevich
authors.forename: V V
authors.initials: VV
authors.lastname: Zinchuk
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001162:Arteriosclerosis Obliterans / Q000097:blood* / Q000601:surgery*; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D005609:Free Radicals / Q000097:blood*; D006801:Humans; D007511:Ischemia / Q000097:blood; D015227:Lipid Peroxidation; D008297:Male; D011150:Popliteal Artery / Q000601:surgery; D015427:Reperfusion Injury / Q000097:blood* / Q000209:etiology; D016909:Tibial Arteries / Q000601:surgery; D014656:Vascular Surgical Procedures
chemical_list: D000975:Antioxidants; D005609:Free Radicals