title: Painful peripheral neuropathy associated with voriconazole use.
abstract: BACKGROUND
  Voriconazole is a new antifungal agent that has been recently introduced into clinical practice. We found no published reports of painful peripheral neuropathy associated with its use.
  
  
  OBJECTIVE
  To describe a unique case of painful peripheral neuropathy associated with voriconazole use.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A 43-year-old patient who had undergone liver transplantation received voriconazole for invasive deep sinus aspergillosis and developed intolerable pain in all extremities.
  
  
  RESULTS
  A laboratory workup and electromyographic and nerve conduction studies were performed to exclude other causes of neuropathy in this complicated patient. Results of electromyographic and nerve conduction studies were suggestive of a demyelinating neuropathy. Symptoms and signs of neuropathy disappeared shortly after voriconazole discontinuation, suggesting a possible role in the development of neuropathy. The patient continues to do well 10 months after this event.
  
  
  CONCLUSIONS
  To our knowledge, this is the first reported case of voriconazole-associated peripheral neuropathy. Awareness of this association and careful monitoring for neurological signs are necessary for patients receiving voriconazole.
authors.affiliation: Academic Department of Medicine, Hippokration General Hospital, 114 Vassilisis, Sofias Avenue, Athens, Greece.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Tsiodras
authors.forename: Rodesa
authors.initials: R
authors.lastname: Zafiropoulou
authors.forename: Efthymia
authors.initials: E
authors.lastname: Kanta
authors.forename: Christos
authors.initials: C
authors.lastname: Demponeras
authors.forename: Nikos
authors.initials: N
authors.lastname: Karandreas
authors.forename: Emanuel K
authors.initials: EK
authors.lastname: Manesis
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D009437:Neuralgia / Q000139:chemically induced*; D010147:Pain Measurement / Q000379:methods; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000150:complications; D011743:Pyrimidines / Q000009:adverse effects*; D014230:Triazoles / Q000009:adverse effects*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole