title: Behavioral features of CHARGE syndrome (Hall-Hittner syndrome) comparison with Down syndrome, Prader-Willi syndrome, and Williams syndrome.
abstract: CHARGE syndrome, or Hall-Hitner syndrome (HHS), has been delineated as a common syndrome that includes coloboma, choanal atresia, cranial nerve dysfunction (particularly asymmetric facial palsy and neurogenic swallowing problems), characteristic ear abnormalities, deafness with hypoplasia of the cochlea and semicircular canals, genital hypoplasia, and variable heart defects, orofacial clefting, tracheo-esophageal fistula, renal anomalies, thymic/parathyroid hypoplasia, spine anomalies, short broad neck with sloping shoulders, and characteristic facial features. We conducted behavioral and personality assessments in 14 boys with HHS syndrome aged 6-21 years, and compared their characteristics with similar data from 20 age-matched boys with Down syndrome (DS), 17 boys with Prader-Willi syndrome (PWS), and 16 boys with Williams syndrome (WS). We used the Reiss Profile of Fundamental Goals and Motivation Sensitivities, the Achenbach Child Behavior Checklist (CBCL), and the Aberrant Behavior Checklist (ABC). All 14 boys with HHS were legally deaf, and 10 of the 14 were also legally blind. In comparison these other syndromes, boys with HHS had behavior that resembled autistic spectrum disorder. They were socially withdrawn, lacked interest in social contact, and manifested reduced seeking of attention from others, with hyperactivity and a need to maintain order. Though the boys with HHS showed decreased social interaction, they were not as socially impaired as in classic autism. Their language was delayed due to dual sensory impairment, cranial nerve deficits, and chronic medical problems, but their language style was not abnormal (no echolalia or jargon, no scripted phrases, and no pronoun reversal). Boys with HSS appeared frustrated, but they were not aggressive, or at risk for delinquency, manifesting few stereotypic behaviors or unusual preoccupations. They did not have a restricted repertoire of activities and interests. Their behavioral features appeared to be due to dual sensory impairment affecting hearing and vision, rather than to primary autistic spectrum disorder, but successful remediation requires similar educational interventions, which are discussed herein.
authors.affiliation: Department of Pediatrics, Medical Genetics Birth Defects Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90048, USA. john.graham@cshs.org
authors.forename: John M
authors.initials: JM
authors.lastname: Graham
authors.forename: Beth
authors.initials: B
authors.lastname: Rosner
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Dykens
authors.forename: Jeannie
authors.initials: J
authors.lastname: Visootsak
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000523:psychology; D001519:Behavior / Q000502:physiology*; D002648:Child; D002754:Choanal Atresia / Q000473:pathology; D003071:Cognition / Q000502:physiology; D003103:Coloboma / Q000473:pathology; D003638:Deafness / Q000473:pathology; D004314:Down Syndrome / Q000503:physiopathology* / Q000523:psychology; D004423:Ear / Q000002:abnormalities; D005835:Genitalia / Q000002:abnormalities; D006130:Growth Disorders / Q000473:pathology; D006330:Heart Defects, Congenital / Q000473:pathology; D006801:Humans; D008297:Male; D011218:Prader-Willi Syndrome / Q000503:physiopathology* / Q000523:psychology; D013577:Syndrome; D018980:Williams Syndrome / Q000503:physiopathology* / Q000523:psychology