title: Antidiabetic effects of extracts from Psidium guajava.
abstract: During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Lepr(db)/Lepr(db) mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10mg/kg in both 1- and 3-month-old Lepr(db)/Lepr(db) mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated Lepr(db)/Lepr(db) mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology (KRIBB), P.O. Box 115, Yusong, Daejeon 305-600, South Korea.
authors.forename: Won Keun
authors.initials: WK
authors.lastname: Oh
authors.forename: Chul Ho
authors.initials: CH
authors.lastname: Lee
authors.forename: Myung Sun
authors.initials: MS
authors.lastname: Lee
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Bae
authors.forename: Cheon Bae
authors.initials: CB
authors.lastname: Sohn
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Oh
authors.forename: Bo Yeon
authors.initials: BY
authors.lastname: Kim
authors.forename: Jong Seog
authors.initials: JS
authors.lastname: Ahn
mesh_terms: D000367:Age Factors; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D005260:Female; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D031647:Psidium
chemical_list: D007004:Hypoglycemic Agents; D010936:Plant Extracts