[Genetic modification of porcine organs for human in xenotransplantation].
Xenotransplantation (XP) from pig into human has been considered as means to overcome the great lack of donor organ available in transplantation surgery. In order to weaken rejection between human and pig,approaches of gene targeting have been proposed to eliminate "rejection gene"alpha-1,3GT from porcine cells directly and accurately.alpha-1,3GT knockout pigs can be produced by nuclear transfer cloning with the porcine cells(knocking out alpha-1,3GT). Besides the genetic modification of alpha-1,3GT in porcine cells,there is another technical way to interdict activity of complement in series for human by XP. However, porcine endogenous retroviruses (PERV) during XP has been thought to not be negligible in being transmitted with the xenograft to the human recipient. Therefore, it is importance task that we should not only knockout alpha-1,3GT and relative molecules from pigs, but also ensure safety in public health of XP from PERV.
Yu
Yuan-Jing
YJ
Xiang Ya Medical College, Central South University, Changsha 410078, China.