title: Quantitative evaluation of immuno- and histochemical reaction intensity by spatial visualization techniques.
abstract: The aim of this study was an application of spatial visualization techniques for quantitative measurements of immuno- and histochemical reactions. For a quantitative histochemical study, specimens, collected from patients with chronic gastritis, were stained with paS/AB, while for immunohistochemical evaluation, specimens were used, collected from patients with chronic parathyroiditis and were analyzed with Ki-67 proliferation marker and apoptosis bcl-2 protein. The new technique permitted to obtain quantitative objective results. Statistical cluster analysis of those results indicated small groups of cases for reevaluation and supported the final diagnosis.
authors.affiliation: Laboratory of Morphometry and Medical Image Processing, University of Medical Sciences, Poznań, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Górna
authors.forename: E
authors.initials: E
authors.lastname: Kaczmarek
authors.forename: E
authors.initials: E
authors.lastname: Nieruchalska
authors.forename: D
authors.initials: D
authors.lastname: Jarmołowska-Jurczyszyn
authors.forename: P
authors.initials: P
authors.lastname: Majewski
mesh_terms: D044963:Biopsy, Fine-Needle / Q000379:methods*; D005756:Gastritis / Q000473:pathology*; D006042:Goiter / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry / Q000379:methods; D010279:Parathyroid Diseases / Q000473:pathology