title: A novel autosomal recessive nonsyndromic hearing impairment locus (DFNB42) maps to chromosome 3q13.31-q22.3.
abstract: A consanguineous family with autosomal recessive nonsyndromic hearing impairment (NSHI) was ascertained in Pakistan and displayed significant evidence of linkage to 3q13.31-q22.3. The novel locus (DFNB42) segregating in this kindred, maps to a 21.6 cM region according to a genetic map constructed using data from both the deCode and Marshfield genetic maps. This region of homozygosity is flanked by markers D3S1278 and D3S2453. A maximum multipoint LOD score of 3.72 was obtained at marker D3S4523. DFNB42 represents the third autosomal recessive NSHI locus to map to chromosome 3.
authors.affiliation: Department of Biological Sciences, Quaid-I-Azam University, Islamabad, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Aslam
authors.forename: Muhammad
authors.initials: M
authors.lastname: Wajid
authors.forename: Maria H
authors.initials: MH
authors.lastname: Chahrour
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ansar
authors.forename: Sayedul
authors.initials: S
authors.lastname: Haque
authors.forename: Thanh L
authors.initials: TL
authors.lastname: Pham
authors.forename: Regie P
authors.initials: RP
authors.lastname: Santos
authors.forename: Kai
authors.initials: K
authors.lastname: Yan
authors.forename: Wasim
authors.initials: W
authors.lastname: Ahmad
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Leal
mesh_terms: D001299:Audiometry; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D034381:Hearing Loss / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree