title: Focus on small molecule inhibitors for treatment of inflammatory and autoimmune diseases.
abstract: The 228th American Chemical Society (ACS) National Meeting was held August 22-26, 2004, in Philadelphia, Pennsylvania. More than 400 medicinal chemistry papers were presented, most in symposia, general sessions and poster sessions sponsored by the ACS Division of Medicinal Chemistry. One major focus of the meeting was the development of novel drugs for the treatment of inflammatory and autoimmune diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease (Crohn's disease), psoriasis, reperfusion injury and endotoxic shock. This report will center on said areas of research.
authors.affiliation: JKBdeinker@aol.com
authors.forename: John K
authors.initials: JK
authors.lastname: Borchardt
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000458:organization & administration / Q000639:trends*; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000276:immunology / Q000627:therapeutic use; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D006801:Humans; D006835:Hydrazones; D007378:Interleukins / Q000037:antagonists & inhibitors / Q000276:immunology / Q000627:therapeutic use; D009025:Morpholines / Q000037:antagonists & inhibitors / Q000276:immunology / Q000627:therapeutic use; D009363:Neoplasm Proteins / Q000276:immunology / Q000627:therapeutic use; D015143:Philadelphia; D011743:Pyrimidines; D047889:Receptors, Tumor Necrosis Factor, Type II; D014227:Triazines / Q000037:antagonists & inhibitors / Q000276:immunology / Q000627:therapeutic use; D053319:Tumor Necrosis Factor Decoy Receptors; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D018925:Chemokines; D006835:Hydrazones; D007378:Interleukins; D009025:Morpholines; D009363:Neoplasm Proteins; D011743:Pyrimidines; D047889:Receptors, Tumor Necrosis Factor, Type II; D014227:Triazines; D053319:Tumor Necrosis Factor Decoy Receptors; D048051:p38 Mitogen-Activated Protein Kinases; C504227:apilimod