Endothelial microparticles and the diagnosis of the vasculitides.
Recently there has been considerable interest in a novel surrogate marker of endothelial injury, endothelial microparticles (EMP), in a number of diseases characterised by endothelial injury. This review examines the data relating to EMP in human disease states, and examines the potential for EMP to provide a window onto the activated endothelium in primary systemic vasculitides. The utility of EMP for the diagnosis and monitoring of active vasculitis is discussed.
Brogan
Paul A
PA
Department of Nephrourology, Institute of Child Health, London.
Dillon
Michael J
MJ
D015415:Biomarkers / Q000032:analysis; D001792:Blood Platelets / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D014657:Vasculitis / Q000175:diagnosis* / Q000378:metabolism
D015415:Biomarkers