title: Kinetics of decomposition of irbesartan in aqueous solutions determined by high performance liquid chromatography.
abstract: The kinetics of breakdown of irbesartan in aqueous solutions at elevated temperatures has been investigated by a high performance liquid chromatography method. The reaction is found to follow first-order kinetics and the rate constant for the degradation at 25 degrees C is estimated by extrapolation. The decomposition of irbesartan is shown to be hydroxide ion catalysed and the effects of ionic strength and buffer concentrations to such rate studies are discussed.
authors.affiliation: DMI Inc, Wharton, NJ 07885-1600, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Mbah
mesh_terms: D000959:Antihypertensive Agents / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry*; D002021:Buffers; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D000077405:Irbesartan; D007700:Kinetics; D012015:Reference Standards; D012996:Solutions; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013777:Tetrazoles / Q000737:chemistry*
chemical_list: D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D002021:Buffers; D012996:Solutions; D013777:Tetrazoles; D000077405:Irbesartan