title: DNA damage detection and repair, and the involvement of epigenetic states.
abstract: Chromatin is a highly dynamic structure that acts alternately as a substrate and a template in a number of critical biological processes. Modification of chromatin is pertinent and is responsible for a number of nuclear processes, including DNA repair, replication, transcription, and recombination. The purpose of this review is to discuss specific interactions between chromatin remodeling, DNA repair, and transcription. These areas are demonstrated to share commonality, particularly with a number of key molecules that appear to have roles in a number of pathways. The implications of pathway cross-over and communication form a seamless continuation of genomic integrity and stability.
authors.affiliation: Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Prahran, Australia.
authors.forename: Sahar
authors.initials: S
authors.lastname: Bassal
authors.forename: Assam
authors.initials: A
authors.lastname: El-Osta
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000502:physiology; D051758:Transcription Factor TFIIH / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D018809:Proliferating Cell Nuclear Antigen; D051758:Transcription Factor TFIIH