[The prognostic significance of regular bone marrow aspirations during induction chemotherapy in acute myeloid leukemia].
OBJECTIVE
To evaluate the prognostic significance of regular aspirations during induction chemotherapy in acute myeloid leukemia.


METHODS
Regular bone marrow aspirations were performed during the first course of induction chemotherapy in 96 cases of de novo AML.


RESULTS
Complete remission (CR) rate after the first course in patients with < or = 0.10 bone marrow blasts at the 7th day on chemotherapy was higher than that in patients with > 0.10 blasts (64.6% vs 40.0%, P < 0.05). Prolonged the chemotherapy course for a few more days in the latter group of patients increased CR rate from 25.0% to 50.0%. CR rate in patients with < or = 0.10 bone marrow blasts at the nadir of white blood cell count after chemotherapy was higher than that in patients with > 0.10 blasts (66.0% vs 25.8%, P < 0.005), and the refractory cases were significantly fewer in the former group of patients (7.5% vs 45.2%, P < 0.005).


CONCLUSIONS
Regular bone marrow aspirations during induction chemotherapy were helpful in predicting the prognosis and guiding the treatment in AML.
Mi
Y
Y
Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.
Bian
S
S
Xue
Y
Y
Zhao
Y
Y
Meng
Q
Q
Guo
Y
Y
Li
R
R
Qin
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001853:Bone Marrow; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult