title: Invasive genetic diagnosis in multiple pregnancies.
abstract: Chromosomal anomalies and mendelian diseases are more frequent in multiple gestations than in singletons. Prenatal diagnosis is recommended in multiple pregnancies whenever indicated. Invasive testing using amniocentesis or chorionic villus sampling can be performed safely. Chorionic villus sampling has a significant advantage over amniocentesis because it offers rapid karyotyping and biochemical and DNA studies at an early stage of pregnancy. Only experienced centers should perform these procedures because of the technical aspects and the expertise needed in handling discordant results.
authors.affiliation: Department of Obstetrics and Gynecology, Kaplan Medical Center, Rehovot 76100, Israel. edith_ap@yahoo.com
authors.forename: Zvi
authors.initials: Z
authors.lastname: Appelman
authors.forename: Boris
authors.initials: B
authors.lastname: Furman
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000649:Amniocentesis / Q000009:adverse effects; D002823:Chorion; D015193:Chorionic Villi Sampling / Q000009:adverse effects; D002869:Chromosome Aberrations; D004200:Diseases in Twins; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011296:Prenatal Diagnosis / Q000009:adverse effects / Q000379:methods*; D014427:Twins