title: The severity of Minamata disease declined in 25 years: temporal profile of the neurological findings analyzed by multiple logistic regression model.
abstract: Minamata disease (MD) was caused by ingestion of seafood from the methylmercury-contaminated areas. Although 50 years have passed since the discovery of MD, there have been only a few studies on the temporal profile of neurological findings in certified MD patients. Thus, we evaluated changes in neurological symptoms and signs of MD using discriminants by multiple logistic regression analysis. The severity of predictive index declined in 25 years in most of the patients. Only a few patients showed aggravation of neurological findings, which was due to complications such as spino-cerebellar degeneration. Patients with chronic MD aged over 45 years had several concomitant diseases so that their clinical pictures were complicated. It was difficult to differentiate chronic MD using statistically established discriminants based on sensory disturbance alone. In conclusion, the severity of MD declined in 25 years along with the modification by age-related concomitant disorders.
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Japan. uchino96@kaiju.medic.kumamoto-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Uchino
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Hirano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Satoh
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Arimura
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Jyunji
authors.initials: J
authors.lastname: Wakamiya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D016015:Logistic Models; D020262:Mercury Poisoning, Nervous System / Q000266:history / Q000503:physiopathology*; D008875:Middle Aged; D008954:Models, Biological; D012720:Severity of Illness Index; D013997:Time Factors