Endothelial dysfunction, atherosclerosis and thrombosis in uremia--possibilities of intervention.
Chronic renal failure is a state of prominent endothelial dysfunction, accelerated atherosclerosis, high incidence of thromboembolic complications and excess cardiovascular mortality. We reviewed up-to-date experimental and clinical data showing close and deleterious links between these entities. Emerging therapeutic interventions aimed at improvement of endothelial function and better clinical outcomes in chronic kidney disease patients were also discussed.
Myśliwiec
M
M
Department of Nephrology and Transplantology with Dialysis Unit, Medical University of Białystok, Poland. mysmich@poczta.onet.pl
Borawski
J
J
Naumnik
B
B
Rydzewska-Rosołowska
A
A
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D013927:Thrombosis / Q000209:etiology* / Q000503:physiopathology