title: Expression of ST13 in colorectal cancer and adjacent normal tissues.
abstract: OBJECTIVE
  To investigate the in situ expression of suppression of tumorigenecity 13 (ST13) mRNA in both colorectal cancer and adjacent normal tissues.
  
  
  METHODS
  Colorectal cancer cell lines SW1116, SW620 and CoLo205 were enrolled to confirm the feasibility of the in situ hybridization procedure. Seven colorectal cancer and adjacent normal tissues were included for RNA-RNA in situ hybridization.
  
  
  RESULTS
  The expression of ST13 in the seven normal colon tissues was positive and the positive signals appeared in mucosal cells. Only three of the seven colorectal cancer tissues had positive hybridization signals that appeared in adenocarcinoma cells.
  
  
  CONCLUSIONS
  The expression of ST13 decreases in colorectal cancer tissue compared with that in adjacent normal tissue. ST13 is mostly expressed in colorectal epithelia and adenocarcinoma cells.
authors.affiliation: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310016, Zhejiang Province, China. wanglinbo@medmail.com.cn
authors.forename: Lin-Bo
authors.initials: LB
authors.lastname: Wang
authors.forename: Shu
authors.initials: S
authors.lastname: Zheng
authors.forename: Su-Zhan
authors.initials: SZ
authors.lastname: Zhang
authors.forename: Jia-Ping
authors.initials: JP
authors.lastname: Peng
authors.forename: Feng
authors.initials: F
authors.lastname: Ye
authors.forename: Shi-Chang
authors.initials: SC
authors.lastname: Fang
authors.forename: Jin-Min
authors.initials: JM
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000378:metabolism*; D045744:Cell Line, Tumor; D003106:Colon / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005240:Feasibility Studies; D006801:Humans; D017403:In Situ Hybridization; D007413:Intestinal Mucosa / Q000378:metabolism*; D008875:Middle Aged; D012007:Rectum / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D018832:Molecular Chaperones
chemical_list: D002352:Carrier Proteins; D025521:Tumor Suppressor Proteins; C101119:ST13 protein, human; D018832:Molecular Chaperones