Gas6, warfarin, and kidney diseases.
The product of growth arrest-specific gene 6 (Gas6) is a unique vitamin K-dependent autocrine growth factor for mesangial cells, and warfarin inhibits mesangial cell proliferation by interfering with the activation process of Gas6. A recent series of studies has revealed the in vivo roles of Gas6 and its receptor Axl in the progression of acute and chronic glomerulonephritis, diabetic nephropathy, chronic allograft rejection, and human kidney diseases. This review summarizes these studies and discusses the possible interventions targeting the Gas6/Axl pathway to prevent the progression of kidney diseases.
Yanagita
Motoko
M
Yanagisawa Orphan Receptor Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, National Museum of Emerging Science and Innovation, Tokyo, Japan. motoy@kuhp.kyoto-u.ac.jp
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000378:metabolism; D005920:Glomerular Mesangium / Q000166:cytology / Q000378:metabolism; D005921:Glomerulonephritis / Q000378:metabolism; D006084:Graft Rejection / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism* / Q000628:therapy; D051379:Mice; D018345:Mice, Knockout; D050796:STAT3 Transcription Factor; D015398:Signal Transduction / Q000502:physiology; D015534:Trans-Activators / Q000378:metabolism; D014812:Vitamin K / Q000378:metabolism; D014859:Warfarin / Q000378:metabolism*; D000099255:Growth Arrest-Specific Protein 6
D004268:DNA-Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; D050796:STAT3 Transcription Factor; D015534:Trans-Activators; D014812:Vitamin K; D014859:Warfarin; D000099255:Growth Arrest-Specific Protein 6; C494086:STAT3 protein, human; C494087:Stat3 protein, mouse