title: Successful treatment of long-standing neuro-Behçet's disease with infliximab.
abstract: Behçet's disease is a chronic relapsing form of vasculitis affecting multiple organs. Central nervous system involvement is a common presentation. Tumor necrosis factor-alpha (TNF-alpha) is considered to play a major role in the disease pathogenesis. We describe a patient with a long history of neuro-Behçet's disease who showed a remarkable response to infliximab therapy. Given the variable and limited success of other interventions, the use of anti-TNF-alpha therapy seems to be effective for patients with refractory disease.
authors.affiliation: Section of Rheumatology, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
authors.forename: Haroon
authors.initials: H
authors.lastname: Sarwar
authors.forename: Hugh
authors.initials: H
authors.lastname: McGrath
authors.forename: Luis R
authors.initials: LR
authors.lastname: Espinoza
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001528:Behcet Syndrome / Q000150:complications / Q000276:immunology / Q000628:therapy*; D002493:Central Nervous System Diseases / Q000150:complications / Q000276:immunology / Q000628:therapy*; D006801:Humans; D000069285:Infliximab; D008297:Male; D012074:Remission Induction; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab