Cerebroside analogues from marine-derived fungus Aspergillus flavipes.
From the mycelium of the marine-derived fungus Aspergillus flavipes, isolated from the sea anemone Anthopleura xanthogrammica, two new cerebroside analogues, namely flavicerebrosides A (1): [(2S,2'R,3R,4E,8E)-N-2'-hydroxyoctadecanoyl-1-O-beta--galactopyranosyl-9-methyl-4,8-sphingadienine], and B (2): [(2S,2'R,3R,3'E,4E,8E)-N-2'-hydroxy-3'-octadecenoyl-1-O-beta--galactopyranosyl-9-methyl-4,8-sphingadienine], together with two known glycosphingolipids cerebrosides D (3) and C (4), were isolated. Their structures were identified by means of extensive spectroscopic analysis (IR, UV, 2D NMR, MS, CD) and chemical degradation. All four compounds showed cytotoxic activity against the KB cell line.
Jiang
Ting
T
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.
Li
Tian
T
Li
Jun
J
Fu
Hong-Zheng
HZ
Pei
Yue-Hu
YH
Lin
Wen-Han
WH
D000970:Antineoplastic Agents / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D002554:Cerebrosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D025282:Mycelium / Q000737:chemistry; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000737:chemistry
D000970:Antineoplastic Agents; D002554:Cerebrosides; C116025:cerebroside C; C438630:cerebroside D; C498912:flavicerebroside A; C498914:flavicerebroside B; D013110:Sphingosine