title: Progressive outer retinal necrosis presenting with isolated optic neuropathy.
abstract: Progressive outer retinal necrosis is a necrotizing herpetic retinopathy usually seen in immunocompromised patients. The authors describe two patients with this disease who initially had findings suggestive of an optic neuropathy. Vision declined after treatment with methylprednisolone, after which fundus examination became consistent with progressive outer retinal necrosis. These cases underscore the importance of careful examination of the retinal periphery before management of any presumed optic neuropathy with steroids.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Nakamoto
authors.forename: E U
authors.initials: EU
authors.lastname: Dorotheo
authors.forename: V
authors.initials: V
authors.lastname: Biousse
authors.forename: R A
authors.initials: RA
authors.lastname: Tang
authors.forename: J S
authors.initials: JS
authors.lastname: Schiffman
authors.forename: N J
authors.initials: NJ
authors.lastname: Newman
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D017726:Cytomegalovirus Retinitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003951:Diagnostic Errors; D004172:Diplopia / Q000209:etiology; D018450:Disease Progression; D018792:Encephalitis, Viral / Q000150:complications / Q000188:drug therapy; D005260:Female; D017245:Foscarnet / Q000627:therapeutic use; D006562:Herpes Zoster / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000009:adverse effects; D008875:Middle Aged; D009336:Necrosis; D009902:Optic Neuritis / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D010291:Paresis / Q000209:etiology; D011241:Prednisone / Q000009:adverse effects; D012160:Retina / Q000473:pathology*
chemical_list: D000998:Antiviral Agents; D017245:Foscarnet; D011241:Prednisone; D000212:Acyclovir; D008775:Methylprednisolone