title: Enantioselective tandem michael addition/H2-hydrogenation catalyzed by ruthenium hydride borohydride complexes containing beta-aminophosphine ligands.
abstract: A variety of ruthenium(II) catalyst precursors containing beta-aminophosphine ligands and a borohydride ligand were found to be active for a one-pot, tandem asymmetric Michael addition/H2-hydrogenation reaction to give the chiral alcohol in excellent diastereomeric excess. The most effective catalyst is 4b, containing the (S)-binap ligand and (R,R)-Pnor ligand, derived from (1S,2R)-norephedrine.
authors.affiliation: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
authors.forename: Rongwei
authors.initials: R
authors.lastname: Guo
authors.forename: Robert H
authors.initials: RH
authors.lastname: Morris
authors.forename: Datong
authors.initials: D
authors.lastname: Song