Bacteremia among children admitted to a rural hospital in Kenya.
BACKGROUND
There are few epidemiologic data on invasive bacterial infections among children in sub-Saharan Africa. We studied every acute pediatric admission to a rural district hospital in Kenya to examine the prevalence, incidence, types, and outcome of community-acquired bacteremia.


METHODS
Between August 1998 and July 2002, we cultured blood on admission from 19,339 inpatients and calculated the incidence of bacteremia on the basis of the population served by the hospital.


RESULTS
Of a total of 1783 infants who were under 60 days old, 228 had bacteremia (12.8 percent), as did 866 of 14,787 children who were 60 or more days of age (5.9 percent). Among infants who were under 60 days old, Escherichia coli and group B streptococci predominated among a broad range of isolates (14 percent and 11 percent, respectively). Among infants who were 60 or more days of age, Streptococcus pneumoniae, nontyphoidal salmonella species, Haemophilus influenzae, and E. coli accounted for more than 70 percent of isolates. The minimal annual incidence of community-acquired bacteremia was estimated at 1457 cases per 100,000 children among infants under a year old, 1080 among children under 2 years, and 505 among children under 5 years. Of all in-hospital deaths, 26 percent were in children with community-acquired bacteremia. Of 308 deaths in children with bacteremia, 103 (33.4 percent) occurred on the day of admission and 217 (70.5 percent) within two days.


CONCLUSIONS
Community-acquired bacteremia is a major cause of death among children at a rural sub-Saharan district hospital, a finding that highlights the need for prevention and for overcoming the political and financial barriers to widespread use of existing vaccines for bacterial diseases.
Berkley
James A
JA
Centre for Geographic Medicine Research (Coast), Kilifi, Kenya. jberkley@kilifi.mimcom.net
Lowe
Brett S
BS
Mwangi
Isaiah
I
Williams
Thomas
T
Bauni
Evasius
E
Mwarumba
Saleem
S
Ngetsa
Caroline
C
Slack
Mary P E
MP
Njenga
Sally
S
Hart
C Anthony
CA
Maitland
Kathryn
K
English
Mike
M
Marsh
Kevin
K
Scott
J Anthony G
JA
D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D001419:Bacteria / Q000302:isolation & purification; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology; D006192:Haemophilus Infections / Q000453:epidemiology; D019741:Haemophilus influenzae type b / Q000302:isolation & purification; D017052:Hospital Mortality; D006780:Hospitals, Rural; D006801:Humans; D015994:Incidence; D007223:Infant; D007630:Kenya / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000453:epidemiology; D011008:Pneumococcal Infections / Q000453:epidemiology; D011446:Prospective Studies