Using ontologies to describe mouse phenotypes.
The mouse is an important model of human genetic disease. Describing phenotypes of mutant mice in a standard, structured manner that will facilitate data mining is a major challenge for bioinformatics. Here we describe a novel, compositional approach to this problem which combines core ontologies from a variety of sources. This produces a framework with greater flexibility, power and economy than previous approaches. We discuss some of the issues this approach raises.
Gkoutos
Georgios V
GV
Bioinformatics Group, MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, UK. g.gkoutos@har.mrc.ac.uk
Green
Eain C J
EC
Mallon
Ann-Marie
AM
Hancock
John M
JM
Davidson
Duncan
D
D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000592:standards; D004195:Disease Models, Animal; D005838:Genotype; D006801:Humans; D008490:Medical Informatics; D051379:Mice / Q000235:genetics* / Q000502:physiology; D010641:Phenotype; D018875:Vocabulary, Controlled