Saponins of Allium elburzense.
A phytochemical investigation of the bulbs of Allium elburzense has been undertaken, leading to the isolation of 13 furostanol and spirostanol saponins, eight of which are new, namely, elburzensosides A1/A2 (1a/1b), B1/B2 (2a/2b), C1/C2 (3a/3b), and D1/D2 (4a/4b). On the basis of spectroscopic analysis, mainly 2D NMR and mass spectrometry, and chemical methods, the structures of the new compounds were determined as furost-2alpha,3beta,5alpha,6beta,22alpha-pentol 3-O-beta-D-glucopyranosyl 26-O-beta-D-glucopyranoside (1a), furost-2alpha,3beta,5alpha,6beta,22alpha-pentol 3-O-[beta-D-glucopyranosyl-(1-->4)-O-beta-D-glucopyranosyl] 26-O-beta-D-glucopyranoside (2a), furost-2alpha,3beta,5alpha,22alpha-tetrol 3-O-beta-D-glucopyranosyl 26-O-beta-D-glucopyranoside (3a), and furost-2alpha,3beta,5alpha,22alpha-tetrol 3-O-[beta-D-xylopyranosyl-(1-->3)-O-beta-D-glucopyranosyl-(1-->4)-O-beta-D-galactopyranosyl] 26-O-beta-D-glucopyranoside (4a), and the corresponding epimers at position 22 (1b-4b). Along with these compounds we have isolated the corresponding 22-O-methyl derivatives that we consider extraction artifacts. All the new elburzensosides A1/A2-D1/D2 possess as a common structural feature an OH-5alphathat is rare among furostanol saponins. The reported compounds have been isolated in large amounts, and this makes A. elburzense a prolific producer of saponins of the furostanol and spirostanol types.
Barile
Elisa
E
Dipartimento di Scienze e Tecnologie Agroalimentari, Ambientali e Microbiologiche, Università del Molise, Via F. De Sanctis, 86100 Campobasso, Italy.
Zolfaghari
Behzad
B
Sajjadi
S Ebrahim
SE
Lanzotti
Virginia
V
D000490:Allium / Q000737:chemistry*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D007492:Iran; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D013150:Spirostans / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
D005663:Furans; D012503:Saponins; D013150:Spirostans