title: CXC chemokines: angiogenesis, immunoangiostasis, and metastases in lung cancer.
abstract: CXC chemokines have been found to be important in the regulation of angiogenesis and tumor-related immunity, and in promoting organ-specific metastases. This review highlights the importance of CXC chemokine ligands and receptors in mediating non-small cell lung cancer tumor-associated angiogenesis, "immunoangiostasis," and organ-specific metastases. These findings may ultimately lead to clinical strategies to target CXC chemokines in non-small cell lung cancer.
authors.affiliation: Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, 900 Veteran Avenue, 14-154 Warren Hall, Los Angeles, CA 90024-1922, USA. rstrieter@mednet.ucla.edu
authors.forename: Robert M
authors.initials: RM
authors.lastname: Strieter
authors.forename: John A
authors.initials: JA
authors.lastname: Belperio
authors.forename: Marie D
authors.initials: MD
authors.lastname: Burdick
authors.forename: Sherven
authors.initials: S
authors.lastname: Sharma
authors.forename: Steven M
authors.initials: SM
authors.lastname: Dubinett
authors.forename: Michael P
authors.initials: MP
authors.lastname: Keane
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D018925:Chemokines / Q000378:metabolism; D019743:Chemokines, CXC / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology*; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology; D009389:Neovascularization, Pathologic; D012333:RNA, Messenger / Q000378:metabolism; D023063:Receptors, Interleukin-8B / Q000378:metabolism
chemical_list: D018925:Chemokines; D019743:Chemokines, CXC; D012333:RNA, Messenger; D023063:Receptors, Interleukin-8B