Synergistic effect of dehydroascorbic acid and mixtures with vitamin E and beta-carotene on mitomycin C efficiency under irradiation in vitro.
Experiments in vitro have shown that dehydroascorbic acid (DHA) possesses antitumor properties under irradiation, which are gradually enhanced by combination with beta-carotene or vitamin E. On the other hand the cytostatic efficiency of mitomycin C (MMC) is increased from deltaD37 = -93 up to deltaD37 = -141 in the presence of DHA. It has also been shown that Escherichia coli bacteria are able, to some extent, to reduce DHA to ascorbate under the same experimental conditions. The results are of interest for the radiation therapy of cancer.
Kammerer
Cornelia
C
Institute for Theoretical Chemistry and Molecular Structure Biology, The University of Vienna A-1090 Wien, Austria.
Getoff
Nikola
N
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D003683:Dehydroascorbic Acid / Q000494:pharmacology* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004338:Drug Combinations; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D005720:Gamma Rays; D016685:Mitomycin / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology* / Q000528:radiation effects; D019207:beta Carotene / Q000494:pharmacology* / Q000528:radiation effects
D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D004338:Drug Combinations; D019207:beta Carotene; D014810:Vitamin E; D016685:Mitomycin; D003683:Dehydroascorbic Acid