Longevity genes: from primitive organisms to humans.
Recent results indicate that the longevity of both invertebrates and vertebrates can be altered through genetic manipulation and pharmacological intervention. Most of these interventions involve alterations of one or more of the following: insulin/IGF-I signaling pathway, caloric intake, stress resistance and nuclear structure. How longevity regulation relates to aging per se is less clear, but longevity increases are usually accompanied by extended periods of good health. How these results will translate to primate aging and longevity remains to be shown.
Warner
Huber R
HR
Biology of Aging Program, Gateway Building, Room 2C231, National Institute on Aging, Bethesda, MD 20892, USA. warnerh@nia.nih.gov
D000375:Aging / Q000235:genetics*; D000818:Animals; D031204:Caloric Restriction; D004265:DNA Helicases / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D002149:Energy Intake; D016158:Genes, p53; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008136:Longevity / Q000235:genetics*; D023421:Models, Animal; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics; D051759:Xeroderma Pigmentosum Group D Protein
D004268:DNA-Binding Proteins; D007328:Insulin; D014157:Transcription Factors; D007334:Insulin-Like Growth Factor I; D011972:Receptor, Insulin; D004265:DNA Helicases; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human