Histomorphometry of marrow megakaryocytes in experimental uraemia in rats.
Uraemic patients frequently demonstrate tendencies towards life-threatening bleeding. Reduced platelet counts and their functional immaturity seem to be caused, among other things, by disorders in the system of marrow megakaryocytes. The aim of the study was a histomorphometric evaluation of marrow megakaryocytes in the course of experimental uraemia in rats. Uraemia was induced by means of right nephrectomy and a partial removal of the left kidney cortex in rats. Morphometric analysis was conducted, using the Microlmage program set. The number of MK, MK area, N/C, CDMK, CDNMK and MK cluster formation were analysed. Uraemic rats showed a reduction in the MK count and their area and an increase in the N/C ratio, CDMK, CDNMK and in the incidence of MK clusters. The results indicate that platelet disorders, observed in uraemia, can also be conditioned by disturbed maturation of MK.
Bogusłowicz
W
W
Department of Human Anatomy, Medical University of Bialystok, Poland. anatomia@amb.edu.pl
Lemancewicz
D
D
Pawlak
D
D
Dziecioł
J
J
D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology*; D004195:Disease Models, Animal; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar; D014511:Uremia / Q000473:pathology*