Regression of pancreatic fibrosis after steroid therapy in patients with autoimmune chronic pancreatitis.
Autoimmune chronic pancreatitis (AICP) is a clinically attractive entity because of its dramatic response to steroid therapy. Reported cases of AICP until now have focused on mainly clinical, radiologic, and laboratory features with steroid therapy. There are, however, few reports that demonstrate histologic recovery, especially regression of pancreatic fibrosis in patients with AICP. Fibrosis in chronic pancreatitis is generally believed to be irreversible. Our observation of reversibility of pancreatic fibrosis is, therefore, noteworthy. We illustrate this with 2 cases of AICP in which pancreatic fibrosis as well as inflammatory infiltration regressed after a short course of oral steroid therapy.
Song
Moon Hee
MH
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Kim
Myung-Hwan
MH
Lee
Sung Koo
SK
Seo
Dong Wan
DW
Lee
Sang Soo
SS
Han
Jimin
J
Kim
Kyu-Pyo
KP
Min
Young Il
YI
Song
Dong Eun
DE
Yu
Ensil
E
Jang
Se Jin
SJ
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000473:pathology*; D005355:Fibrosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D050500:Pancreatitis, Chronic / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology*; D011239:Prednisolone / Q000008:administration & dosage*
D000893:Anti-Inflammatory Agents; D011239:Prednisolone