Associations with autoimmune disorders and HLA class I and II antigens in inclusion body myositis.
Whether autoimmune mechanisms play a role in the pathogenesis of inclusion body myositis (IBM) is unknown. Human leukocyte antigen (HLA) analysis in 52 patients, including 17 with autoimmune disorders (AIDs), showed that patients were more likely to have antigens from the autoimmune-prone HLA-B8-DR3 ancestral haplotype than healthy control subjects, irrespective of the presence of AIDs. Patients lacked the apparently protective HLA-DR53 antigen. The results provide further support for an autoimmune basis in IBM.
Badrising
U A
UA
Department of Neurology, K5Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. ubadrising@lumc.nl
Schreuder
G M Th
GM
Giphart
M J
MJ
Geleijns
K
K
Verschuuren
J J G M
JJ
Wintzen
A R
AR
Maat-Schieman
M L C
ML
van Doorn
P
P
van Engelen
B G M
BG
Faber
C G
CG
Hoogendijk
J E
JE
de Jager
A E
AE
Koehler
P J
PJ
de Visser
M
M
van Duinen
S G
SG
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D015897:Comorbidity; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D006681:HLA-D Antigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics / Q000276:immunology; D059845:HLA-DRB4 Chains; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D018979:Myositis, Inclusion Body / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence
D006680:HLA Antigens; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; C050610:HLA-DR53; D059845:HLA-DRB4 Chains