title: Polymerase chain reaction in the management of disseminated adenovirus infection after stem cell transplantation.
abstract: We report a 20-month-old child with disseminated adenovirus infection after a haploidentical T cell-depleted stem cell transplantation. This case demonstrates the value of polymerase chain reaction surveillance for early detection of adenovirus infection and the role of quantitative polymerase chain reaction for monitoring antiviral therapy. It also emphasizes the importance of T cell immunity in controlling disseminated adenovirus infection after stem cell transplantation.
authors.affiliation: Academic Department of Child Health, Royal London Hospital, United Kingdom. t.m.walls@qmul.ac.uk
authors.forename: Tony
authors.initials: T
authors.lastname: Walls
authors.forename: Khidir
authors.initials: K
authors.lastname: Hawrami
authors.forename: Delane
authors.initials: D
authors.lastname: Shingadia
authors.forename: Ines
authors.initials: I
authors.lastname: Ushiro-Lumb
authors.forename: Ananti
authors.initials: A
authors.lastname: Shankar
mesh_terms: D000258:Adenovirus Infections, Human / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008212:Lymphocyte Depletion; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D016133:Polymerase Chain Reaction / Q000379:methods*; D013601:T-Lymphocytes / Q000276:immunology