Prerequisites for combinatorial biosynthesis: evolution of hybrid NRPS/PKS gene clusters.
Shen
B
B
Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin-Madison, WI 53705, USA. bshen@pharmacy.wisc.edu
Chen
M
M
Cheng
Y
Y
Du
L
L
Edwards
D J
DJ
George
N P
NP
Huang
Y
Y
Oh
T
T
Sanchez
C
C
Tang
G
G
Wendt-Pienkowski
E
E
Yi
F
F
D001665:Binding Sites; D020650:Combinatorial Chemistry Techniques; D018942:Macrolides / Q000378:metabolism*; D005810:Multigene Family; D010452:Peptide Biosynthesis; D046908:Peptide Biosynthesis, Nucleic Acid-Independent; D010453:Peptide Synthases / Q000235:genetics*; D048630:Polyketide Synthases / Q000235:genetics*; D013379:Substrate Specificity
D018942:Macrolides; D048630:Polyketide Synthases; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase