title: [Immunological phenomenons in the pathology of the tear film. Is cyclosporine the turn point in the Sjögren's syndrome treatment? Preliminary report].
abstract: OBJECTIVE
  The purpose of this study is to examine the new way in the casual treatment, resulting in the normalization of immunological processes on the ocular surface.
  
  
  METHODS
  5 patients (4 women and 1 men with mean age of 55.5 years, range 45 to 59 years) with Sjögren's syndrome--type dry eye, were included in the study. Patients received topically 0.05% cyclosporine, ophthalmic emulsion twice a day for a 6 months. The severity of patients complaints was evaluated according to the Dr. Mann Pharma/Bausch & Lomb's record.
  
  
  RESULTS
  Schirmer test II values, and lyzamine green staining scores, were evaluated priori to treatment and 6 months after the start. At the beginning of the study (day 0) the Schirmer test II values ranged from 1 to 5 mm (mean--2.2 mm). Break-up-time ranged from 3 to 6 sec (mean--4.8 sec). In all of 5 cases lyzamine green staining scores were 9. On month 6th, all of 5 patients had significant differences, compared to their baseline measurements in term of above mentioned parameters. The Schirmer test II values ranged from 8 to 12 mm (mean--10.3 mm). Break-up-time ranged from 9 to 13 sec (mean--11.2 sec), lyzamine green staining scores ranged from 2 to 3 points (mean--2.7).
  
  
  CONCLUSIONS
  0.05% cyclosporine, ophthalmic emulsion had a beneficial effect both on the subjective and objective clinical parameters of dry eye patients. The final conclusions must be supported by more cases.
authors.affiliation: Kliniki Okulistycznej Wojskowego Instytutu Medycznego w Warszawie.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kujawa
authors.forename: Radosław
authors.initials: R
authors.lastname: Rózycki
mesh_terms: D016572:Cyclosporine / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications*; D013666:Tears / Q000276:immunology
chemical_list: D016572:Cyclosporine