title: [Contractile responses of the airways smooth muscles in experimental bronchial asthma; the role of interleukin 5 in formation of hyper-responsiveness of bronchial tubes].
abstract: By mehanographic method, contraktile responses of the airways smooth muscles in experimental bronchial asthma in porpoises intact and incubated with interleykin-5, were studied. Sensitization of ovalbumin animals results in development of hypersensitivity to inhalation of the fiber with external attributes of infringement of bronchial passableness such as cough and a shortness of breath. Morphologically the process is accompanied by destruction of epithelium of the bronchial tubes, development of an immune inflammation in a bronchial wall, and a hypertrophy of the muscular layer. In the sensitized animals, development of hyper-responsiveness of the airways smooth muscles to histamine was obvious as shown in a significant decrease of the threshold concentration and an increase in the maximal amplitude of reduction. Interleukin-5 was shown to strengthen this process. Responses to holinergic and R2-adrenerdic influences practically did not change. The data obtained corroborate the hypothesis of development of the interleukin-5-depending bronchial hyper-responsiveness in absence of eosinophile damage in the mucous membrane of the bronchial tubes.
authors.forename: L V
authors.initials: LV
authors.lastname: Kapilevich
authors.forename: L M
authors.initials: LM
authors.lastname: Ogorodova
authors.forename: A é
authors.initials: Aé
authors.lastname: Sazonov
authors.forename: E Iu
authors.initials: EIu
authors.lastname: D'iakova
authors.forename: I S
authors.initials: IS
authors.lastname: Popova
authors.forename: A V
authors.initials: AV
authors.lastname: Nosarev
authors.forename: T N
authors.initials: TN
authors.lastname: Zaĭtseva
mesh_terms: D000818:Animals; D001249:Asthma / Q000473:pathology / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D006168:Guinea Pigs; D015848:Interleukin-5 / Q000008:administration & dosage* / Q000378:metabolism; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000473:pathology / Q000503:physiopathology*; D020545:Respiratory Mucosa / Q000473:pathology / Q000503:physiopathology
chemical_list: D015848:Interleukin-5