The pulmonary biology of isoprostanes.
Isoprostanes were first recognized as convenient markers of oxidative stress, but their powerful effects on a variety of cell functions are now also being increasingly appreciated. This is particularly true of the lung, which is comprised of a wide variety of different cell types (smooth muscle, innervation, epithelium, lymphatics, etc.), all of which have been shown to respond to exogenously applied isoprostanes. In this review, we summarize these biological responses in the lung, and also consider the roles that isoprostanes might play in a range of pulmonary clinical disorders.
Janssen
Luke J
LJ
Asthma Research Group, Father Sean O'Sullivan Research Center, Firestone Institute for Respiratory Health, St. Joseph's Hospital, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. janssenl@mcmaster.ca
Catalli
Adriana
A
Helli
Peter
P
D000818:Animals; D015415:Biomarkers; D016207:Cytokines / Q000096:biosynthesis; D004594:Electrophysiology; D004848:Epithelium / Q000378:metabolism; D028441:F2-Isoprostanes / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D007249:Inflammation; D028421:Isoprostanes / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D015227:Lipid Peroxidation; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008171:Lung Diseases / Q000378:metabolism* / Q000473:pathology; D008954:Models, Biological; D008956:Models, Chemical; D009130:Muscle, Smooth / Q000378:metabolism; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D015398:Signal Transduction; D014665:Vasodilator Agents / Q000494:pharmacology
D015415:Biomarkers; D016207:Cytokines; D028441:F2-Isoprostanes; D005609:Free Radicals; D028421:Isoprostanes; D014665:Vasodilator Agents; D010100:Oxygen