Demonstration of the lapachol as a potential drug for reducing cancer metastasis.
Metastasis is the major process responsible for the death in cancer patients. In the search for more effective antineoplasic drugs, many substances are under investigation, among them lapachol. This study aims to examine the molecular and morphological alterations caused by lapachol treatment, as well as its effects on the intrinsic tissue invasive property of this cell line. HeLa cells were exposed to different concentrations of lapachol, and the resulting alterations on cellular protein profile, morphology and invasiveness property were studied. At 400 microg/ml, cellular viability remains unchanged, but lapachol induces alterations in the protein profile and inhibits the invasiveness of HeLa cells in CAM model. With these results, we can conclude that lapachol has a great potential of application in fighting metastasis.
Balassiano
Ilana Teruszkin
IT
Instituto de Biofísica Carlos Chagas Filho, Laboratório de Controle da Expressão Gênica, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Bloco C, Cidade Universitária, CEP 21949-900, Rio de Janeiro, RJ, Brasil.
De Paulo
Sheila Alves
SA
Henriques Silva
Nathalie
N
Cabral
Maulori Curié
MC
da Gloria da Costa Carvalho
Maria
M
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D009285:Naphthoquinones / Q000494:pharmacology* / Q000627:therapeutic use; D009361:Neoplasm Invasiveness / Q000473:pathology; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D009285:Naphthoquinones; C008252:lapachol