title: Isomalabaricane-type compounds from the marine sponge Rhabdastrella aff. distincta.
abstract: Fractionation of the marine sponge Rhabdastrella aff. distincta led to the isolation and characterization of four new isomalabaricane analogues, isogeoditin A (1), 13-(E)-isogeoditin A (2), isogeoditin B (3), and 22,23-dihydrostellettin B (4), along with seven known isomalabaricane derivatives (5-11). Methylation of 10 and 11 afforded methyl esters 12 and 13. The structures of compounds 1-4 were determined on the basis of spectroscopic data analysis. All compounds were tested against a small panel of human tumor cell lines.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Lv
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Deng
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Hongzheng
authors.initials: H
authors.lastname: Fu
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D012118:Resorcinols; D014315:Triterpenes; C445692:geoditin A