title: Isochromosome of a deleted 20q: a rare but recurrent chromosome abnormality in myelodysplastic syndromes.
abstract: Interstitial deletion of the long arm of chromosome 20, as the sole abnormality, is commonly observed in myeloid malignancies, including myeloproliferative disorder, myelodysplastic syndrome, and acute myeloid leukemia. The breakpoints of the deletion are typically located in the region 20q11.2 approximately q13.3, although smaller deletions within this region have also been reported. We present here 4 patients with myelodysplastic syndrome with an isochromosome of the deleted long arm of chromosome 20: ider(20)(q10)del(20)(q11q13). Fluorescence in situ hybridization studies were performed on the bone marrow samples from these patients to prove the identity of this unusual chromosome abnormality.
authors.affiliation: Department of Haematology, King's College Hospital, Denmark Hill, London, UK. karensaundrs@hotmail.com
authors.forename: K
authors.initials: K
authors.lastname: Saunders
authors.forename: B
authors.initials: B
authors.lastname: Czepulkowski
authors.forename: R
authors.initials: R
authors.lastname: Sivalingam
authors.forename: J P L A
authors.initials: JP
authors.lastname: Hayes
authors.forename: M
authors.initials: M
authors.lastname: Aldouri
authors.forename: M
authors.initials: M
authors.lastname: Sekhar
authors.forename: M
authors.initials: M
authors.lastname: Cummins
authors.forename: A
authors.initials: A
authors.lastname: Ho
authors.forename: G J
authors.initials: GJ
authors.lastname: Mufti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018404:Isochromosomes / Q000235:genetics*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*