title: Formation of human cementum following different modalities of regenerative therapy.
abstract: The aim of the present study was to compare newly formed cementum following different types of regenerative therapy in humans. Eighteen patients, each displaying one advanced intrabony defect around teeth scheduled for extraction, were included in this study. The defects were treated with either guided tissue regeneration (GTR), enamel matrix protein derivative (EMD), EMD plus bioactive glass, bovine-derived xenograft (BDX), BDX plus GTR, or BDX plus EMD. After healing, the teeth were removed together with their surrounding soft and hard tissues. Cellular content, presence of artifactual splits between the new cementum and the old one or the dentin surface, and thickness of the new cementum were evaluated. Irrespective of treatment, the new cementum was of a reparative, cellular, extrinsic and intrinsic fiber type. There were no differences in cementum thickness among treatments. These findings indicate that in humans, (a) the new cementum formed after different types of regenerative therapy was, irrespective of the treatment, of a reparative, cellular, extrinsic and intrinsic fiber type, and (b) the regenerative modality does not seem to influence the type of newly formed cementum.
authors.affiliation: Department of Periodontology and Biomaterials, Radboud University Nijmegen, Philips van Leydenlaan 25, Internal Postal Code 117, 6500 HB, Nijmegen, The Netherlands. a.sculean@dent.umcn.nl
authors.forename: A
authors.initials: A
authors.lastname: Sculean
authors.forename: A
authors.initials: A
authors.lastname: Stavropoulos
authors.forename: M
authors.initials: M
authors.lastname: Berakdar
authors.forename: P
authors.initials: P
authors.lastname: Windisch
authors.forename: T
authors.initials: T
authors.lastname: Karring
authors.forename: M
authors.initials: M
authors.lastname: Brecx
mesh_terms: D000818:Animals; D016025:Bone Transplantation / Q000379:methods; D002417:Cattle; D025021:Cementogenesis / Q000187:drug effects*; D003746:Dental Enamel Proteins / Q000627:therapeutic use; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D014183:Transplantation, Heterologous / Q000379:methods
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins