Meroterpenoid MAPKAP (MK2) inhibitors isolated from the indonesian marine sponge Acanthodendrilla sp.
(+)-Makassaric acid (1) and (+)-subersic acid (2), new meroterpenoid inhibitors of the protein kinase MK2, have been isolated from the marine sponge Acanthodendrilla sp. collected in Indonesia. The structures of (+)-makassaric acid (1) and (+)-subersic acid (2) were determined by spectroscopic analysis.
Williams
David E
DE
Department of Chemistry, University of British Columbia, Vancouver, B.C., V6T 1Z1, Canada.
Telliez
Jean-Baptiste
JB
Liu
Julie
J
Tahir
Akbar
A
van Soest
Rob
R
Andersen
Raymond J
RJ
D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D020128:Inhibitory Concentration 50; D047908:Intracellular Signaling Peptides and Proteins; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000099190:MAP-Kinase-Activated Kinase 2
D004791:Enzyme Inhibitors; D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; D013729:Terpenes; D000099190:MAP-Kinase-Activated Kinase 2; C497304:makassaric acid; C497305:subersic acid