title: Isolation of an amikacin-resistant Escherichia coli strain after tobramycin treatment of previous recurrent episodes of respiratory tract infections caused by Pseudomonas aeruginosa.
abstract: Amikacin-resistant Escherichia coli strains are isolated rarely from clinical samples. In the present study, investigation of an amikacin-resistant clinical isolate of E. coli demonstrated the presence of two class 1 integrons carrying the aacA4 gene plus the aacA7 gene, and the dfrA17 gene plus the aadA5 gene, respectively. Resistance to amikacin in this E. coli isolate was related to the presence of both aacA4 and aacA7.
authors.affiliation: Servei de Microbiologia, Hospital Clínic, Villarroel, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ruiz
authors.forename: S
authors.initials: S
authors.lastname: Bertran
authors.forename: G
authors.initials: G
authors.lastname: Sauca
authors.forename: A
authors.initials: A
authors.lastname: Julià
authors.forename: X
authors.initials: X
authors.lastname: Vila
authors.forename: E
authors.initials: E
authors.lastname: Gómez
authors.forename: M T
authors.initials: MT
authors.lastname: Jiménez de Anta
authors.forename: J
authors.initials: J
authors.lastname: Vila
mesh_terms: D000583:Amikacin / Q000494:pharmacology* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000235:genetics*; D006801:Humans; D032023:Integrons / Q000235:genetics; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology; D014031:Tobramycin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D000583:Amikacin; D014031:Tobramycin