Vasodilator constituents from the roots of Lysidice rhodostega.
Two new phloroglucinol glycosides, lysidisides A and B, and two new flavanol ramifycations, lysidicichin and mopanolside, together with (+)-mopanol, polydatin and E-resveratrol 3-O-beta-D-xylopyranoside were isolated from the EtOAc extract of the roots of Lysidice rhodostega. The structures of the new compounds were elucidated on the basis of chemical and spectral evidence. Lysidisides A and B, (+)-mopanol and polydatin inhibited phenylepherine (Phe)-induced vasoconstriction in the rat aortic rings in the presences of indomethacin (Indo) and Nomega-L-nitroarginine (L-NA).
Gao
Song
S
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Feng
Nan
N
Yu
Shishan
S
Yu
Dequan
D
Wang
Xiaoliang
X
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology*
D047309:Flavones; D006027:Glycosides; D010936:Plant Extracts; D014665:Vasodilator Agents