title: Oral candidosis by Candida albicans in normal and xerostomic mice.
abstract: The aim of this study was to analyze the effect of sialoadenectomy on the development of oral candidosis after one or four inoculations of Candida albicans. Initially, a suspension containing 10(8) cells/ml of C. albicans ATCC 36801 was prepared. Seventy-eight sialoadenectomized mice and a similar amount of mice with normal salivary flow received a single inoculation of C. albicans suspension. Another group with a similar number of mice received 4 inoculations. The control group consisted of 6 sialoadenectomized mice and 6 mice with normal salivary flow that were not inoculated with C. albicans. Candidosis development was studied histologically in the tongue of the animals 1, 2, 3, 5, and 8 days after inoculation and at 15-day intervals up to 165 days. According to the results obtained, it could be concluded that sialoadenectomy and a higher frequency of yeast inoculation influenced the presence and extension of candidosis lesions.
authors.affiliation: Department of Oral Pathology, School of Dentistry of Piracicaba, State University of Campinas.
authors.forename: Marilda Aparecida Gonçalves
authors.initials: MA
authors.lastname: Totti
authors.forename: Elisabete Brasil
authors.initials: EB
authors.lastname: dos Santos
authors.forename: Oslei Paes
authors.initials: OP
authors.lastname: de Almeida
authors.forename: Cristiane Yumi
authors.initials: CY
authors.lastname: Koga-Ito
authors.forename: Antonio Olavo Cardoso
authors.initials: AO
authors.lastname: Jorge
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000302:isolation & purification* / Q000472:pathogenicity; D002180:Candidiasis, Oral / Q000382:microbiology* / Q000473:pathology; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D013363:Submandibular Gland / Q000601:surgery*; D013997:Time Factors; D014987:Xerostomia / Q000150:complications*