title: The structure of foot-and-mouth disease virus.
abstract: Structural studies of foot-and-mouth disease virus (FMDV) have largely focused on the mature viral particle, providing atomic resolution images of the spherical protein capsid for a number of sero- and sub-types, structures of the highly immunogenic surface loop, Fab and GAG receptor complexes. Additionally, structures are available for a few non-structural proteins. The chapter reviews our current structural knowledge and its impact on our understanding of the virus life cycle proceeding from the mature virus through immune evasion/inactivation, cell-receptor binding and replication and alludes to future structural targets.
authors.affiliation: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK.
authors.forename: E E
authors.initials: EE
authors.lastname: Fry
authors.forename: D I
authors.initials: DI
authors.lastname: Stuart
authors.forename: D J
authors.initials: DJ
authors.lastname: Rowlands
mesh_terms: D036022:Capsid Proteins / Q000737:chemistry; D029544:Foot-and-Mouth Disease Virus / Q000737:chemistry* / Q000648:ultrastructure*; D016679:Genome, Viral; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism; D017361:Viral Nonstructural Proteins / Q000737:chemistry; D019065:Virus Assembly
chemical_list: D036022:Capsid Proteins; D019812:Heparan Sulfate Proteoglycans; D016023:Integrins; D011991:Receptors, Virus; D017361:Viral Nonstructural Proteins