Cytochrome p450 enzymes and cardiovascular disease.
The cytochrome p450 (CYP) superfamily is responsible for the oxidation, peroxidation, and (or) reduction of vitamins, steroids, xenobiotics, and the majority of cardiovascular drugs in an oxygen- and NADPH-dependent manner. Although hepatic CYP have been studied extensively, the role of CYP in cardiovascular physiology and disease is poorly understood. Increasing evidence suggests that these enzymes play an important role in the pathogenesis of a number of cardiovascular diseases. The current review summarizes the understanding as to the role that dysregulated CYP expression and (or) activity may play in the onset and progression of cardiovascular disease.
Hunter
Arwen L
AL
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada.
Cruz
Rani P
RP
Cheyne
Bo M
BM
McManus
Bruce M
BM
Granville
David J
DJ
D000818:Animals; D002318:Cardiovascular Diseases / Q000201:enzymology*; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology
D003577:Cytochrome P-450 Enzyme System