High-resolution reference ranges for estradiol, luteinizing hormone, and follicle-stimulating hormone in men and women using the AxSYM assay system.
OBJECTIVE
High-resolution reference ranges are essential for reproductive hormones due to the significant day-to-day variation seen with these analytes.


METHODS
The performance of AxSYM assays for estradiol, luteinizing hormone (LH), and follicle-stimulating hormone was evaluated.


RESULTS
These studies validate the performance of each assay, permitting high-resolution reference ranges to be established.


CONCLUSIONS
The high-resolution reference range data provided herein for both normally cycling females and males should be applicable to a wide variety of clinical situations.
Dighe
Anand S
AS
Clinical Chemistry Laboratory, Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. asdighe@partners.or
Moy
Joseph M
JM
Hayes
Frances J
FJ
Sluss
Patrick M
PM
D000293:Adolescent; D000328:Adult; D004958:Estradiol / Q000097:blood / Q000592:standards*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000592:standards*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000592:standards*; D008297:Male; D008598:Menstruation; D008722:Methods; D008875:Middle Aged; D012016:Reference Values
D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone