A randomized crossover trial of tenoxicam compared with rofecoxib for postoperative dental pain control.
Two non-steroidal anti-inflammatory drugs, tenoxicam and rofecoxib, were compared for the control of postoperative pain following surgical extraction of bilaterally and symmetrically impacted wisdom teeth performed under intravenous sedation and local anaesthesia. Thirty-five young fit adult patients received each analgesic treatment for four days in a randomized, crossover design. The results suggest statistically better pain relief for the selective COX-2 inhibitor rofecoxib compared to tenoxicam, a traditional NSAID. There were side-effects with both treatments. Abdominal discomfort was significantly more common following rofecoxib compared to tenoxicam. Both analgesics were acceptable to most participants in the trial.
Zacharias
M
M
Dunedin School of Medicine and School of Dentistry, University of Otago, Dunedin, New Zealand.
De Silva
R K
RK
Herbison
P
P
Templer
P
P
D000293:Adolescent; D000328:Adult; D016001:Confidence Intervals; D018592:Cross-Over Studies; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007783:Lactones / Q000008:administration & dosage*; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D016017:Odds Ratio; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy*; D017060:Patient Satisfaction; D010894:Piroxicam / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D011336:Probability; D013450:Sulfones / Q000008:administration & dosage*; D014081:Tooth Extraction / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome
D016861:Cyclooxygenase Inhibitors; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib; D010894:Piroxicam; C032801:tenoxicam