Comparison of differing C-reactive protein assay methods and their impact on cardiovascular risk assessment.
A medium-sensitivity assay for C-reactive protein (CRP) was compared with a high-sensitivity, enhanced immunoturbidimetric assay in 803 angiographically studied patients. Different absolute CRP values were found by the assays, but there was a high correlation by quartile rank and similar predictive values for death and myocardial infarction. This suggests that the conclusions of previous studies performed using the medium-sensitivity assay are still valid but that cross-study comparisons should use percentile rank.
Clarke
Jessica L
JL
Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA.
Anderson
Jeffrey L
JL
Carlquist
John F
JF
Roberts
Richard F
RF
Horne
Benjamin D
BD
Bair
Tami L
TL
Kolek
Matthew J
MJ
Mower
Chrissa P
CP
Crane
Ashle M
AM
Roberts
William L
WL
Muhlestein
Joseph B
JB
D001774:Blood Chemical Analysis / Q000379:methods; D002097:C-Reactive Protein / Q000032:analysis*; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D002097:C-Reactive Protein