title: [Tumor marker in primary lung cancer].
abstract: Serum tumor markers are non-invasive diagnostic tools for malignant tumor and commonly used for screening of cancer and as an indicator of treatment-effect. In small cell lung cancer, NSE and proGRP are effective markers. In non-small cell lung cancer (NSCLC), CEA, SCC, CYFRA21-1, SLX and CA19-9 are commonly used for screening, and at least one marker among CEA, SCC or CYFRA21-1 is positive in 77% of patients with NSCLC. According to the histological type, the positive rate of CEA and CYFRA21-1 is high in adenocarcinoma patients, and the positive rate of CYFRA21-1 and SCC is high in squamous cell carcinoma patients. This review summarizes the clinical usefulness of tumor markers in primary lung cancer.
authors.affiliation: Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugio
authors.forename: Masakazu
authors.initials: M
authors.lastname: Sugaya
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hanagiri
authors.forename: Kosei
authors.initials: K
authors.lastname: Yasumoto
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D018288:Carcinoma, Small Cell / Q000175:diagnosis*; D006801:Humans; D053539:Keratin-19; D007633:Keratins; D016256:Lewis X Antigen / Q000097:blood; D008175:Lung Neoplasms / Q000175:diagnosis*; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D011994:Recombinant Proteins / Q000097:blood; D015843:Serpins / Q000097:blood
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; D016256:Lewis X Antigen; D010446:Peptide Fragments; D010455:Peptides; D011994:Recombinant Proteins; D015843:Serpins; C102012:antigen CYFRA21.1; C087079:pro-gastrin-releasing peptide (31-98); C051072:squamous cell carcinoma-related antigen; D007633:Keratins