Pulmonary artery pressure in Ladakhi men on exposure to acute hypoxia after a stay at sea level.
We had observed that very few Ladakhi soldiers (native highlanders: NHL) are hospitalized for high altitude pulmonary oedema. We hypothesized that this may happen because pulmonary artery pressures of NHLs do not increase even after exposure to acute hypoxia. The aim of this study was to test the above hypothesis by non-invasive echocardiographic assessment of pulmonary arterial pressure in freshly inducted Ladakhi soldiers and comparing it with that in freshly inducted lowlander soldiers (LL). The pre-ejection period and acceleration time ratio as measured from the pulmonary artery Doppler signal was used to compute mean pulmonary arterial pressure. In NHL this pressure on day 1 of induction was significantly lower at 25.8 +/- 6.5 mmHg as compared to 31.9 +/- 9.5 mmHg in LL (P = 0.0002). Another finding of interest was the very low Lake Louise acute mountain sickness score in the NHL (0.278 +/- 0.461 on day 2). This appears to be further evidence that the natives of Ladakh are adapted to hypoxia and not merely acclimatized.
Apte
C V
CV
High Altitude Medical Research Centre, Leh, Ladakh, India.
D000064:Acclimatization / Q000502:physiology; D000328:Adult; D000531:Altitude; D001794:Blood Pressure / Q000502:physiology*; D004777:Environment; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D007194:India; D008297:Male; D011651:Pulmonary Artery / Q000502:physiology*