title: Synthesis, characterization, DNA-binding and photocleavage studies of [Ru(bpy)2(PPIP)]2+ and [Ru(phen)2(PPIP)]2+.
abstract: A novel ligand 2-(4'-phenoxy-phenyl)imidazo[4,5-f][1,10]phenanthroline (PPIP) and its complexes [Ru(bpy)(2)(PPIP)](2+) (1) (bpy = 2,2'-bipyridine) and [Ru(phen)(2)(PPIP)](2+) (2) (phen = 1,10-phenanthroline) have been synthesized and characterized by mass spectroscopy, (1)H NMR and cyclic voltammetry. The interaction of two complexes with calf thymus DNA (CT-DNA) was investigated by spectroscopic and viscosity measurements. The results suggest that both complexes bind to DNA via an intercalative mode. Both complexes have also been found to promote the photocleavage of plasmid pBR 322 DNA under irradiated.
authors.affiliation: Department of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China.
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Tan
authors.forename: Hui
authors.initials: H
authors.lastname: Chao
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Yun-Jun
authors.initials: YJ
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Liang-Nian
authors.initials: LN
authors.lastname: Ji
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000187:drug effects; D066298:In Vitro Techniques; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D010618:Phenanthrolines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D010777:Photochemistry; D010957:Plasmids / Q000187:drug effects; D012428:Ruthenium; D021241:Spectrometry, Mass, Electrospray Ionization; D013053:Spectrophotometry
chemical_list: D007364:Intercalating Agents; D009942:Organometallic Compounds; D010618:Phenanthrolines; D012428:Ruthenium; D004247:DNA