title: Prevalence of Aspergillus species in clinical samples isolated in an Indian tertiary care hospital.
abstract: CONTEXT (BACKGROUND): In recent times, it has become important to determine the prevalence of different Aspergillus species in clinical samples in view of difference in antifungal susceptibility noted in some species.
  
  
  OBJECTIVE
  To determine the species prevalence of Aspergillus isolates in various clinical samples received in the Mycology Laboratory at our institute.
  
  
  METHODS
  Over a period of 4-years, a total of 18,731 samples were processed, and species identification carried out by standard microbiological methods.
  
  
  RESULTS
  Four hundred and fifty six samples (2.43%) were culture positive for Aspergillus species. A.flavus (46.93%) was the most common isolate, followed by A.fumigatus (37.72%) and A.niger (15.35%). It was observed that A.fumigatus was the predominant species isolated from blood and respiratory specimens, A.flavus was predominantly isolated from nasal polyps whereas A.niger predominated in nail specimens. Culture positivity was highest in the age group 12-65 years and in males. Sixty-nine patients (15.13%) were admitted to the intensive care unit.
  
  
  CONCLUSIONS
  The study highlights the diverse manifestations caused by Aspergillus species in human beings and also throws light on the different species prevalent locally. The knowledge would prove useful in selecting empirical antifungal therapy and formulating prophylactic and pre-emptive strategies.
authors.affiliation: Department of Microbiology, All India Institute of Medical Sciences, New Delhi - 29, India. i_xess@yahoo.com
authors.forename: Immaculata
authors.initials: I
authors.lastname: Xess
authors.forename: Srujana
authors.initials: S
authors.lastname: Mohanty
authors.forename: Neena
authors.initials: N
authors.lastname: Jain
authors.forename: Uma
authors.initials: U
authors.lastname: Banerjee
mesh_terms: D001228:Aspergillosis / Q000453:epidemiology / Q000382:microbiology*; D001231:Aspergillus flavus / Q000302:isolation & purification*; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D001234:Aspergillus niger / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D015995:Prevalence