Cytotoxic iridoid aldehydes from Taiwanese Viburnum luzonicum.
Four new iridoid aldehydes bearing (E)- or (Z)-p-coumaroyl group, luzonial A (1), luzonial B (2), luzonidial A (3), and luzonidial B (4), were isolated from a methanol extract of the dried leaves of Viburnum luzonicum collected in Kaoshiung, Taiwan and their structures were elucidated by analysis of spectroscopic data. Compounds 1-3 exhibited moderate inhibitory activity against HeLa S3 cancer cells.
Fukuyama
Yoshiyasu
Y
Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan. fukuyama@ph.bunri-u.ac.jp
Minoshima
Yuka
Y
Kishimoto
Yoshiko
Y
Chen
Ih-Sheng
IS
Takahashi
Hironobu
H
Esumi
Tomoyuki
T
D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D049109:Cell Proliferation / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D018515:Plant Leaves; D013624:Taiwan; D027925:Viburnum
D000447:Aldehydes; D039823:Iridoids; D010936:Plant Extracts