title: Measuring the efficacy of rhBMP-2 to regenerate bone: a radiographic study using a commercially available software program.
abstract: This radiographic study evaluated the efficacy of different concentrations of rhBMP-2 to regenerate bone in alveolar defects in the anterior maxilla. The study was performed using reasonably standardized CT examinations and the Simplant program. The radiographic measurements were further refined by careful standardization of the measured regions of interest. There was a statistically significant difference in bone formation between subjects treated with a concentration of 1.5 mg/mL rhBMP-2 compared with each of the other groups. There was no statistically significant difference in bone volume between any of the other groups. None of the groups showed a loss in bone volume.
authors.affiliation: Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston 02115, USA.
authors.forename: Jorge
authors.initials: J
authors.lastname: Bianchi
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Fiorellini
authors.forename: T Howard
authors.initials: TH
authors.lastname: Howell
authors.forename: Julio
authors.initials: J
authors.lastname: Sekler
authors.forename: Hugh
authors.initials: H
authors.lastname: Curtin
authors.forename: Marc L
authors.initials: ML
authors.lastname: Nevins
authors.forename: Bernard
authors.initials: B
authors.lastname: Friedland
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery; D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000187:drug effects; D000540:Alveolar Ridge Augmentation; D015519:Bone Density / Q000187:drug effects; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000601:surgery; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012984:Software; D014057:Tomography, X-Ray Computed; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta