[Lymphocytes sensitization to insulin in acute ischemic attacks].
The study aimed at investigation of frequency and character of lymphocyte sensitization to insulin in patients with acute disturbances of brain blood circulation (ADBBC). Fifty patients with ADBBC (38-with ischemic stroke, 5-with hemorrhagic stroke, 7-with transient ischemic attacks), 17 patients with cerebrovascular diseases (CVD) and 20 age- and sex-matched controls have been studied. Lymphocyte sensitization to insulin (LS) was revealed in 32 patients with stroke and in 5-with CVD. Direct LS to insulin occured in 6 patients with stroke, all of them having diabetes mellitus type I. Indirect LS to insulin, defectable after inhibition of the cells with histamine receptors (CHR) or prostaglandin synthetizing cells (PGSC), was found in 26 patients with stroke (10-with diabetes type 2, 8-with pre-diabetes, 8 non-diabetic) and in 5 patients with CVD. Indirect LS to insulin is a key factor in development of insulin resistance. High PGSC activity is associated with CVD and transient ischemic attacks and high CHR activity is associated with stroke. Diabetes mellitus caused a severer course of ADBBC, and arterial hypertension may result in the ADBBC development in one third of patients.
Asfandiiarova
N S
NS
Riazantsev
I V
IV
Riazantsev
V S
VS
D000208:Acute Disease; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D002545:Brain Ischemia / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011451:Prostaglandin-Endoperoxide Synthases / Q000097:blood
D007328:Insulin; D011451:Prostaglandin-Endoperoxide Synthases