[Effects of qianggu electuary on ovariectomized osteoporotic rats].
OBJECTIVE
To observe the effects of qianggu electuary (QGE), a Chinese herbal preparation, on ovariectomy-induced osteoporotic rats.


METHODS
Female Wistar rats were ovariectomized and administered QGE, calcium gluconate (CG) and longmu zhuanggu granules (LMZG) for 12 weeks. Bone mineral density (BMD), indexes of biomechanics and serum E2, Ca were detected in grouped rats including QGE, CG, LMZG and control groups.


RESULTS
QGE could significantly increase the BMD and maximum load, maximum stress YP-load of femora in the osteoporotic rats. The values of E2 in ovariectomized osteoporotic rats decreased, compared with those of control normal rats (P > 0.05), while in the QGE treated rats, the values of E2 increased.


CONCLUSIONS
QGE can increase the BMD and improve indexes of bone biomechanics in ovariectomized osteopotic rats, possibly due to its estrogen-like effect.
Peng
Tao
T
Han kou Railway Hospital, Wuhan, 400010, Hubei, China.
Huang
Mang-li
ML
Xiong
Wei
W
Wang
Lan
L
Yang
Yan-ping
YP
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005269:Femur / Q000503:physiopathology; D010024:Osteoporosis / Q000097:blood / Q000473:pathology / Q000503:physiopathology; D010052:Ovariectomy; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D004958:Estradiol; D002118:Calcium