Antiviral effect of chinonin against herpes simplex virus.
In order to investigate the antiviral effect of chinonin against Herpes simplex virus (HSV), the encephalitis model in mice and skin infection model in guinea pigs were established by HSV- I and HSV-II infection respectively. Acyclovir was used as the positive reference drug to evaluate the antiviral capacity of chinonin. Chinonin showed an obvious therapeutic effect on encephalitis in mice at doses of 25 and 50 mg/kg. At both dosages, chinonin demonstrated stronger protection than acyclovir (1 and 5 mg/kg) to the infected mice from death. It was also found that chinonin could treat the skin infection in guinea pigs effectively. The therapeutic effect of chinonin was similar to that of acyclovir (5 mg/kg) at 25 mg/kg but obviously better than that at 50 and 75 mg/ kg. In conclusion, chinonin is a potential candidate for the treatment against HSV.
Jiang
Jie
J
Department of Pharmacology, School of Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Li
Sha
S
Li
Ming
M
Xiang
Jizhou
J
D000212:Acyclovir / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004660:Encephalitis / Q000188:drug therapy / Q000821:virology; D006027:Glycosides / Q000494:pharmacology*; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000188:drug therapy; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D051379:Mice; D018139:Simplexvirus / Q000187:drug effects*; D012874:Skin Diseases, Infectious / Q000188:drug therapy; D014966:Xanthenes / Q000494:pharmacology*; D044004:Xanthones
D000998:Antiviral Agents; D006027:Glycosides; D014966:Xanthenes; D044004:Xanthones; C013592:mangiferin; D000212:Acyclovir