title: [The apolipoprotein E polymorphism in age related macular degeneration].
abstract: OBJECTIVE
  The aim of the study was to evaluate association of apo E polymorphism with AMD.
  
  
  METHODS
  The included participants of this study were: 45 patients aged 60 to 71 (mean age 66.2 +/- 3.6), treated because of AMD. Genomic DNA was extracted from peripheral blood leukocytes, and the subsequent analysis of apo E genotypes was performed by polymerase chain reaction (PCR).
  
  
  RESULTS
  In our study the allele frequencies in control group of patients weresimilar to the apo E allele distribution presented by other authors in Caucasian populations. We have not found significant differences between AMD and control group patients for apo (E) genotype or allele frequency. Compared with control group (epsilon4 -13.6%, epsilon2 -2.27%), the frequency of epsilon4 allele was not significantly decreased (11.11%) and epsilon2 allele frequency (7.77%) increased in AMD patients.
  
  
  CONCLUSIONS
  The results of our present study have not indicate a significant association between AMD development and apo E allele frequency, in our studied population of AMD patients.
authors.affiliation: Zakładu Patofizjologii Katedry Patofizjologii i Endokrynologii Slaskiej Akademii Medycznej.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Nowak
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Swietochowska
authors.forename: Bozena
authors.initials: B
authors.lastname: Szapska
authors.forename: Bogdan
authors.initials: B
authors.lastname: Marek
authors.forename: Tomasz
authors.initials: T
authors.lastname: Wielkoszyński
authors.forename: Henryk
authors.initials: H
authors.lastname: Kozioł
authors.forename: Joanna
authors.initials: J
authors.lastname: Klimek
authors.forename: Dariusz
authors.initials: D
authors.lastname: Kajdaniuk
authors.forename: Beata
authors.initials: B
authors.lastname: Kos-Kudła
authors.forename: Zofia
authors.initials: Z
authors.lastname: Ostrowska
authors.forename: Jacek
authors.initials: J
authors.lastname: Karpe
authors.forename: Joanna
authors.initials: J
authors.lastname: Głogowska-Szelag
authors.forename: Lucyna
authors.initials: L
authors.lastname: Siemińska
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E