title: Serological markers of persistent C. trachomatis infections in women with tubal factor subfertility.
abstract: BACKGROUND
  Persistent C. trachomatis infections are assumed to increase the risk of tubal pathology. We studied whether serological markers, assumed to be associated with persistent C. trachomatis infections, could identify subfertile women at risk of tubal pathology.
  
  
  METHODS
  Sera of 313 subfertile women, who all underwent a laparoscopy with tubal testing to assess the grade of tubal pathology, were tested for the presence of immunoglobulin (Ig) G and IgA antibodies to C. trachomatis, IgG antibodies to chlamydia heat shock protein 60 (cHSP60) and C-reactive protein (CRP).
  
  
  RESULTS
  C. trachomatis IgA, cHSP60 IgG and CRP, all serological markers of persistent infections, were significantly more prevalent in women with tubal pathology as compared to those without tubal pathology. The predictive value of the currently used screening test for tubal pathology (IgG to C. trachomatis) could be significantly improved by adding the CRP test.
  
  
  CONCLUSIONS
  In subfertile women with tubal pathology, serological markers of persistent C. trachomatis infections are significantly more common as compared to women without tubal pathology. C. trachomatis IgG-positive subfertile women with slightly elevated (< 10 mg/l) CRP levels are at highest risk of persistent C. trachomatis infections and tubal pathology.
authors.affiliation: Research Institute Growth and Development (GROW) and Department of Obstetrics and Gynaecology, Academisch Ziekenhuis Maastricht, P.O.Box 5800, 6202 AZ Maastricht, The Netherlands. jedh@sgyn.azm.nl
authors.forename: J E
authors.initials: JE
authors.lastname: den Hartog
authors.forename: J A
authors.initials: JA
authors.lastname: Land
authors.forename: F R M
authors.initials: FR
authors.lastname: Stassen
authors.forename: A G H
authors.initials: AG
authors.lastname: Kessels
authors.forename: C A
authors.initials: CA
authors.lastname: Bruggeman
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000453:epidemiology* / Q000276:immunology; D002692:Chlamydia trachomatis; D005184:Fallopian Tube Diseases / Q000097:blood / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007247:Infertility, Female / Q000097:blood / Q000453:epidemiology / Q000382:microbiology*; D011237:Predictive Value of Tests; D012307:Risk Factors; D016036:Seroepidemiologic Studies
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D002097:C-Reactive Protein