Antimicrobial peptide microbicides targeting HIV.
Cationic antimicrobial peptides and proteins are among the earliest molecular effectors of the innate arm of immunity in humans and other vertebrates. This review, inspired by recent emphasis on the development of topical preventatives for sexually transmitted infections, describes antimicrobial peptides and proteins in the context of microbicide design and development. Particular emphasis is placed on the defensin family of peptides.
Cole
Alexander M
AM
Department of Molecular Biology and Microbiology, Biomolecular Science Center, University of Central Florida, Bldg 20, Room 136, 4000 Central Florida Blvd., Orlando, FL 32816-2364, USA. acole@mail.ucf.edu
D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000494:pharmacology; D023082:Defensins / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D005260:Female; D006678:HIV / Q000737:chemistry / Q000187:drug effects / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data
D019380:Anti-HIV Agents; D023181:Antimicrobial Cationic Peptides; D023082:Defensins