[The effects of lupus anticoagulant on pulmonary thromboembolism].
OBJECTIVE
To evaluate the effects of lupus anticoagulant (LA) on pulmonary thromboembolism (PTE).


METHODS
Thirty-eight patients with PTE (17 massive and 21 submassive) and 30 healthy adults were studied. Russell's viper venom time (RVVT) was used to examine the ratio of LA (LAR), and a colorimetric method was used to detect the activity of plasma protein C (PC:A) and radioimmunoassay (RIA) was employed to measure the level of plasma thromboxane B(2) (TXB(2)) and 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha).


RESULTS
Compared with the normal group, LAR, TXB(2) and TXB(2)/6-keto-PGF1alpha showed significant increase in the massive PTE and the submassive PTE groups (P < 0.01), and the levels were higher in the massive group than in the submassive group (P < 0.01). Both groups showed significant decrease in PC:A and 6-keto-PGF1alpha compared with the normal group (P < 0.01).


CONCLUSIONS
LA can increase TXB(2)/6-keto-PGF1alpha and decrease PC:A in patients with PTE. It is suggested that there may be an association between the increase of LAR and the presence of PTE.
Wang
Ming-Shan
MS
Laboratory of First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
Pan
Jing-Ye
JY
Wang
Xiao-Xia
XX
Xu
Fei
F
Chen
Xiao-Dong
XD
Tao
Zhi-Hua
ZH
Wang
Liang-Xing
LX
Xie
Yu-Peng
YP
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000097:blood; D011655:Pulmonary Embolism / Q000097:blood* / Q000209:etiology / Q000473:pathology; D011863:Radioimmunoassay; D013923:Thromboembolism / Q000517:prevention & control; D013929:Thromboxane B2 / Q000097:blood*
D016682:Lupus Coagulation Inhibitor; D011453:Prostaglandins; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D002097:C-Reactive Protein