[Diagnosing disorders of iron metabolism. Begin with ferritin].
Diagnosing disorders of iron metabolism the concentration of the iron storing protein ferritin reflects the body's iron reserves much better than does serum iron concentrations or transferring saturation. Merely in the event of acute phase reactions is the validity of the ferretin level compromised. This applies in particular to the redistribution of iron in anemia caused by inflammatory conditions or malignancies, as also, though less markedly, to functional iron deficiency in renal anemia. Here, an additional diagnostic work-up, in particular when EPO/iron therapy is applied. Iron overload should be recognized already in the latent state before organ damage occurs. Clinically and chemically confirmed iron overload that cannot be ascribed to hematological disease, iron replacement of transfusions, should prompt a molecular-biological analysis of hemochromatosis-associated genetic defects.
Wick
Manfred
M
Institut für Klinische Chemie der LMU, München. manfred.wick@med.uni-muenchen
D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D002648:Child; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood; D019190:Iron Overload / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood; D009369:Neoplasms / Q000097:blood; D011247:Pregnancy; D006435:Renal Dialysis; D012680:Sensitivity and Specificity
D005293:Ferritins; D007501:Iron