title: Physiological effects and active ingredients of Viburnum dilatatum Thunb fruits on oxidative stress.
abstract: The fruit of Viburnum dilatatum Thunb, called gamazumi in Japan, showed the strong antioxidant activities, and its preventive effects on oxidative stress and active ingredients were investigated. Male rats were subjected to water immersion restraint stress for 6 hours, after ingestion of the gamazumi crude extract (GCE) for 2 weeks. The formation of gastric ulcer was reduced, and the lipid peroxidation in plasma and organs also lowered in rats ingested GCE. In the streptozotocin-induced diabetic rats given GCE for 10 weeks, inhibition of lipid peroxidation in plasma, erythrocytes and organs was observed, and the increase of plasma glucose level also lowered. On the other hand, two cyanidin glycosides, two chlorogenic acids and quercetin were identified, and especially cyanidin 3-sambubioside (Cy 3-sam) showed the strong radical scavenging activity. It is suggested that Cy 3-sam is a key compound contributing to the physiological effects of V. dilatatum fruit.
authors.affiliation: Division of Environmental Technology, Aomori Industrial Research Center, 4-11-6 Daini-tonyamachi, Aomori 030-0113, Japan. iwai@aomori-tech.go.jp
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Iwai
authors.forename: Mi-Yeon
authors.initials: MY
authors.lastname: Kim
authors.forename: Akio
authors.initials: A
authors.lastname: Onodera
authors.forename: Hajime
authors.initials: H
authors.lastname: Matsue
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000187:drug effects; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D027925:Viburnum
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances