Evaluation of long-term effects of endoscopic injection of collagen into the urethral submucosa for treatment of urethral sphincter incompetence in female dogs: 40 cases (1993-2000).
OBJECTIVE
To evaluate long-term success of endoscopic injection of collagen into the urethral submucosa in female dogs with urinary incontinence caused by urethral sphincter incompetence.


METHODS
Retrospective study.


METHODS
40 incontinent female dogs.


METHODS
Medical records were reviewed for outcome and other results for dogs in which a cystoscope was passed into the urethra for deposition of 3 collagen deposits into the submucosa.


RESULTS
27 (68%) dogs were continent for 1 to 64 months (mean, 17 months) after the collagen injection. In another 10 dogs, incontinence improved and in 6 of these dogs, full continence was regained with administration of additional medication. In 3 dogs, incontinence was unchanged. As long as 12 months after injection, there was a deterioration in the initial result in 16 dogs, after which their condition stabilized. Mild and transient adverse effects developed in 6 (15%) dogs.


CONCLUSIONS
Long-term success of endoscopic injection of collagen was satisfactory. Relapse of incontinence might be caused by flattening of the collagen deposits rather than resorption of the collagen.
Barth
Andrea
A
Section of Small Animal Reproduction, Department of Small Animals, Faculty of Veterinary Medicine, Zurich University, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
Reichler
Iris M
IM
Hubler
Madeleine
M
Hässig
Michael
M
Arnold
Susi
S
D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D014521:Urethra / Q000187:drug effects / Q000502:physiology; D014549:Urinary Incontinence / Q000628:therapy / Q000662:veterinary*; D014555:Urination Disorders / Q000628:therapy / Q000662:veterinary*; D014563:Urodynamics / Q000187:drug effects / Q000502:physiology
D003094:Collagen