Knockout knockouts.
Deletion of the genes for a variety of neuropeptides or their receptors has provided great insight into the physiological roles played by those peptides. Strikingly, several of these knockout models mature into very similar metabolic phenotypes, providing clues to the mechanisms underlying the regulation of glucose homeostasis, cardiovascular regulation and the hormonal response to stress.
Samson
Willis K
WK
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104, USA. samsonwk@slu.edu
Taylor
Meghan M
MM
D000818:Animals; D017353:Gene Deletion; D006801:Humans; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology; D013234:Stem Cells / Q000502:physiology*; D013312:Stress, Physiological / Q000235:genetics / Q000503:physiopathology
D010455:Peptides