title: The BpsIR quorum-sensing system of Burkholderia pseudomallei.
abstract: BpsIR, a LuxIR quorum-sensing homolog, is required for optimal expression of virulence and secretion of exoproducts in Burkholderia pseudomallei. Cell density-dependent expression of bpsI and bpsR, the positive regulation of bpsIR expression by BpsR, and the synthesis of N-octanoyl-homoserine lactone (C8HSL) by BpsI are described in this report.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, National University of Singapore, 8 Medical Dr., Singapore 117597, Singapore.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Chao
authors.initials: C
authors.lastname: Xie
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Ong
authors.forename: Yunn-Hwen
authors.initials: YH
authors.lastname: Gan
authors.forename: Kim-Lee
authors.initials: KL
authors.lastname: Chua
mesh_terms: D000222:Adaptation, Physiological; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D016957:Burkholderia pseudomallei / Q000235:genetics / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D006714:Homoserine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000378:metabolism; D007783:Lactones / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D007783:Lactones; C085427:LuxI protein, Bacteria; C091088:N-octanoylhomoserine lactone; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C064778:LuxR autoinducer binding proteins; D006714:Homoserine