[Progress on polydactyly character of vertebrate].
Polydactyly is a common abnormal limb phenotype in vertebrate and there is similar limb phenotype among different species. Research shows that polydactyly has a similar development mechanism, and this kind of polydactyly character seems to be controlled by homologous genes among species. The latest research results on human and mouse further shows that PPD should be caused by the disruption of a long range cis-acting regulator for Shh within Lmbr1 intron. Here the development mechanism and related genes controlling polydactyly character of vertebrate are reviewed.
Huang
Yan-Qun
YQ
State Key National Laboratory of Biotechnology, China Agricultural University, Beijing 100 094, China. hyanqun@yahoo.com.cn
Deng
Xue-Mei
XM
Li
Ning
N
Qiu
Xiang-Pin
XP
D000818:Animals; D002889:Chromosomes, Human, Pair 2; D002897:Chromosomes, Human, Pair 7; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007438:Introns; D051741:Kruppel-Like Transcription Factors / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics; D010641:Phenotype; D017689:Polydactyly / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics; D000074290:Zinc Finger Protein Gli3
C065683:GLI3 protein, human; C513184:HOXD13 protein, human; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins; D051741:Kruppel-Like Transcription Factors; C485955:LMBR1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C509239:SHH protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D000074290:Zinc Finger Protein Gli3