title: Patient with immunoproliferative disease and lung carcinoma: a case report.
abstract: There are a number of reports on collision occurrence of non-hematologic cancers and Non-Hodgkin's lymphoma (NHL) and multiple myeloma. In this report we present a case of patient with immunoproliferative disease, extramedullary plasmocytoma and NHL-lymphoplasmocytoid lymphoma (LPL) and squamous cell carcinoma of the lung. After diagnosis of extramedullary plasmocytoma cytostatic therapy was commenced and the patient was well. Five years after patient was clinically worse and diagnostic evaluation this time revealed lymphoplasmocytoid cells in bone marrow. Five months later malignant morphologically undifferentiated cells were found in bone marrow which were by immunocytochemistry established as CD38 positive. After the patient's death, disseminated NHL-LPL and squamous cell carcinoma of lung was confirmed. In the report, we compared clinical course and diagnostic findings of our patient with literature data. We have also discussed the possible relationship of multiple B-cell lymphoid tumors and squamous cell carcinoma concluding that multidiscplinary diagnostic tools are essential not only for carcinoma diagnosis and follow-up, but also for further understanding of carcinogenesis.
authors.affiliation: Department of Hematology of Clinics for Internal Diseases, Zagreb University Clinical Hospital Center and School of Medicine, Zagreb, Croatia.
authors.forename: Ivo
authors.initials: I
authors.lastname: Radman
authors.forename: Mirna
authors.initials: M
authors.lastname: Sucić
authors.forename: Ranka
authors.initials: R
authors.lastname: Serventi-Seiwerth
authors.forename: Dubravka
authors.initials: D
authors.lastname: Boban
authors.forename: Mirjana
authors.initials: M
authors.lastname: Marković-Glamocak
authors.forename: Suncica
authors.initials: S
authors.lastname: Ries
authors.forename: Koraljka
authors.initials: K
authors.lastname: Gjadrov-Kuvezdić
authors.forename: Drazen
authors.initials: D
authors.lastname: Petković
authors.forename: Jasminka
authors.initials: J
authors.lastname: Jakić-Razumović
authors.forename: Mira
authors.initials: M
authors.lastname: Sćukanec-Spoljar
authors.forename: Sven
authors.initials: S
authors.lastname: Seiwerth
authors.forename: Zvonimir
authors.initials: Z
authors.lastname: Sucić
authors.forename: Jurica
authors.initials: J
authors.lastname: Papa
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000473:pathology*; D008297:Male; D010954:Plasmacytoma / Q000150:complications / Q000473:pathology