title: [Treatment with caspofungin of Candida tropicalis endocarditis resistant to fluconazol].
abstract: Fungal endocarditis, in particular due to Candida species, requires medical and surgical treatment and amphotericin B is the drug of choice. Caspofungin is an echinocandin very effective against Candida and Aspergillus. We present a patient with Candida tropicalis endocarditis, fluconazol resistant, treated with caspofungin, on a compassional basis as a result of adverse effects with amphotericin B. The patient had a microbiological response.
authors.affiliation: FLENI (Instituto de Investigaciones Neurológicas Raúl Carrea), Buenos Aires, Argentina. mdelcastillo@fleni.org.ar
authors.forename: Marcelo
authors.initials: M
authors.lastname: del Castillo
authors.forename: Nestor
authors.initials: N
authors.lastname: Wainsztein
authors.forename: Francisco
authors.initials: F
authors.lastname: Klein
authors.forename: Silvana
authors.initials: S
authors.lastname: Manganello
authors.forename: Nora
authors.initials: N
authors.lastname: Orellana
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D041022:Candida tropicalis / Q000187:drug effects*; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy*; D000077336:Caspofungin; D025141:Drug Resistance, Fungal; D054714:Echinocandins; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology; D017809:Fatal Outcome; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D055666:Lipopeptides; D008297:Male; D010456:Peptides, Cyclic / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D015725:Fluconazole; D000077336:Caspofungin