A new target for POLO in meiotic centromere cohesion.
The POLO kinase is a key regulator of the release of sister chromatid cohesion at the onset of mitotic anaphase, as well as of other features of the mitotic and meiotic processes. In this issue of Developmental Cell, Clarke et al. show that POLO also regulates the function of the MEI-S332 protein, which plays a critical role in the maintenance of sister chromatid cohesion at the centromere during meiosis.
Lake
Cathleen M
CM
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
Hawley
R Scott
RS
D000818:Animals; D002503:Centromere / Q000378:metabolism*; D029721:Drosophila Proteins / Q000502:physiology*; D004331:Drosophila melanogaster; D008540:Meiosis / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*
D029721:Drosophila Proteins; C072004:polo protein, Drosophila; D017346:Protein Serine-Threonine Kinases