[Role of uncoupling proteins in the pathogenesis of obesity and type II diabetes].
Uncoupling proteins (UCPs) are mitochondria carrier proteins,which are able to dissipate the proton gradient of the inner mitochondria membrane. The uncoupling procedure reduces the amount of ATP generated through an oxidation of fuels. Therefore, UCPs are suggested as candidate genes for human obesity or type II diabetes mellitus. Experimental evidences,that genetically engineered mice over expressing different UCP homologues were resistant to diet-induced obesity and 45 bp insertion polymorphism in the UCP2 3' untranslated region and C-55T in UCP3 promoter region were associated with obesity related phenotype, supported the hypothesis. The roles of UCP genes in polygenic obesity and type II diabetes are evaluated and discussed in this paper.
Wan
Chun-Ling
CL
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Ahang
Tie-Mei
TM
Wang
Li
L
Yang
Ze
Z
Feng
Feng
F