[Serum cystatin C in haemodialysed patients].
BACKGROUND
Cystatin C (CyC) is protein (m. w. 13 300), which is produced by nucleated cells, filtered through glomeruli and subsequently reabsorbed and degraded in tubuli.


OBJECTIVE
To investigate changes in serum CyC concentration during two low-flux membrane haemodialyses (HD-I, HD-II) and relationship between serum CyC a creatinine concentrations.


METHODS
Serum CyC was determined in 17 patients on chronic haemodialysis during HD-I and HD-II by immunonephelometric method (Dade Behring, Austria).


RESULTS
Significant correlation between serum CyC and creatinine before HD-I and before/after HD-II was found (p < 0.001). Serum CyC before HD-I (median 6.3 mg/I, 95 % CI 5.5 - 6.7) increased after HD-I (7.1 mg/l, 6.1 - 8.9) (p < 0.001). Serum CyC before HD-II (6.4 mg/l, 5.8 - 7.2) increased after HD-II (8.0 mg/l, 7.3 - 9) (p < 0.001), while serum creatinine decreased after HD-I and HD-II (p < 0.001). There was correlation between the increase in serum CyC and albumin during HD-I (p < 0.001) and HD-II (p < 0.01).


CONCLUSIONS
There was close correlation between serum CyC and creatinine before haemodialyses. Serum CyC increased after haemodialyses, due to CyC non-dialysability through low-flux membrane and haemoconcentration. Unlike creatininaemia, serum CyC reflects the residual renal function even after haemodialyses.
Pontuch
P
P
IV. interná klinika Lekárskej fakulty UK, Nemocnica sv. Cyrila a Metoda, Bratislava, Slovenská republika.
Lehotská
A
A
Parrák
V
V
Mart'áková
L
L
Fekete
J
J
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D006435:Renal Dialysis; D012709:Serum Albumin / Q000032:analysis
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D012709:Serum Albumin; D003404:Creatinine