Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.
Yamada
Kazuhiko
K
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA.
Yazawa
Koji
K
Shimizu
Akira
A
Iwanaga
Takehiro
T
Hisashi
Yosuke
Y
Nuhn
Matthew
M
O'Malley
Patricia
P
Nobori
Shuji
S
Vagefi
Parsia A
PA
Patience
Clive
C
Fishman
Jay
J
Cooper
David K C
DK
Hawley
Robert J
RJ
Greenstein
Julia
J
Schuurman
Henk-Jan
HJ
Awwad
Michel
M
Sykes
Megan
M
Sachs
David H
DH
D000818:Animals; D030801:Animals, Genetically Modified; D003404:Creatinine / Q000378:metabolism; D004187:Disaccharides / Q000276:immunology / Q000378:metabolism; D005700:Galactosyltransferases / Q000235:genetics* / Q000378:metabolism; D016030:Kidney Transplantation; D010215:Papio; D013552:Swine; D013950:Thymus Gland / Q000637:transplantation*; D013997:Time Factors; D014183:Transplantation, Heterologous / Q000276:immunology
D004187:Disaccharides; C055075:galactosyl-(1-3)galactose; D003404:Creatinine; D005700:Galactosyltransferases