Autoantibody synthesis in primary progressive multiple sclerosis patients treated with interferon beta-1b.
We conducted an open-labeled clinical trial of interferon beta-1b (IFNB) treatment in 20 patients with primary progressive multiple sclerosis (PPMS) and longitudinally monitored autoantibodies against double-stranded DNA (dsDNA), thyroid peroxidase (TPO),myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), synapsin and S-100B. Before treatment, one patient had elevated TPO antibodies, four patients had elevated antibodies against S-100B, two patients against MOG or synapsin and one patient against MBP. In two patients we observed a continuous increase of dsDNA or TPO antibodies above the normal range. This rise paralleled IFNB treatment. In addition, 11 of 20 patients developed neutralizing antibodies against IFNB. There was no increase of autoantibodies directed against central nervous system antigens. Like patients with relapsing remitting or secondary progressive multiple sclerosis, PPMS patients may be at risk of an autoimmune response during IFNB treatment.
Bitsch
Andreas
A
Neurologische Klinik, Ruppiner Kliniken GmbH, Fehrbelliner Strabe 38, 16816, Neuruppin, Germany. a.bitsch@ruppiner-kliniken.de
Dressel
Alexander
A
Meier
Kathrin
K
Bogumil
Timon
T
Deisenhammer
Florian
F
Tumani
Hayrettin
H
Kitze
Bernd
B
Poser
Sigrid
S
Weber
Frank
F
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000276:immunology* / Q000627:therapeutic use*; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000188:drug therapy* / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D011994:Recombinant Proteins; D000068576:Interferon beta-1b; D016899:Interferon-beta; D004247:DNA; D007453:Iodide Peroxidase