Constituents from the stems of Hibiscus taiwanensis.
Five new compounds, hibicuslide A (1), hibicuslide B (2), hibicuslide C (3), hibicutaiwanin (4), hibicusin (5), and fifty-one known compounds have been isolated from the stems of Hibiscus taiwanensis. The structures of these compounds were determined by spectroscopic and chemical transformation methods. Among them, mansonone H (19) and uncarinic acid A (30) inhibited HIV replication in H9 lymphocyte cells. The 9,9'-O-feruloyl-(-)-secoisolaricinresinol (12), myriceric acid C (29), and uncarinic acid A (30) showed cytotoxic activity against human lung carcinoma and breast carcinoma.
Wu
Pei-Lin
PL
Department of Chemistry, National Cheng Kung University, Taiwan. wupl@mail.ncku.edu.tw
Wu
Tian-Shung
TS
He
Cai-Xia
CX
Su
Chia-Hao
CH
Lee
Kuo-Hsiung
KH
D045744:Cell Line, Tumor; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D031584:Hibiscus; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000821:virology; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems
D010936:Plant Extracts