[Biological properties of bacteriophages, active to Yersinia enterocolitica].
The biological properties of 16 clones of Y. enterolitica bacteriophages were tested to select the most active for subsequent use. For the first time Y. enterocolitica virulent phages belonging to the family of Podoviridae were described and 7 serological groups of phages with no cross reactions were registered. The technology for the production of new therapeutic and prophylactic Y. enterocolitica polyvalent bacteriophage under laboratory conditions was developed. The effective multiplicity of contamination ensuring the maximum release of phages from bacterial cells, the optimum incubation temperature and the time of exposure were established. The experimental batches of therapeutic and prophylactic Y. enterocolitica polyvalent bacteriophage thus obtained met the requirements for antibacterial preparations.
Darsavelidze
M A
MA
Kapanadze
Zh S
ZhS
Chanishvili
T G
TG
D001433:Bacteriolysis; D017902:Podoviridae / Q000145:classification / Q000254:growth & development*; D012703:Serotyping; D013696:Temperature; D013997:Time Factors; D015009:Yersinia Infections / Q000517:prevention & control; D015008:Yersinia enterocolitica / Q000276:immunology / Q000821:virology*