title: [New insights in the adjuvant treatment of gastric cancer].
abstract: The current standard treatment of patients with gastric cancer is partial or total stomach resection and dissection of the draining lymph nodes. This approach, however, results in a rather low survival rate, partly because the diagnosis is often established in an advanced stage. Various strategies, including adjuvant radiotherapy, chemotherapy or more extensive surgical procedures, have resulted mainly in increased morbidity without improving survival. In a recent randomised trial, concurrent postoperative radiotherapy and chemotherapy prolonged survival and reduced the chance of a local recurrence at an acceptable toxicity. Although several aspects of combined radiochemotherapy require further study, this new treatment concept appears to be a promising addition to the therapeutic arsenal for gastric cancer.
authors.affiliation: Afd. Radiotherapie, Het Nederlands Kanker Instituut/Antoni van Leeuwenhoek Ziekenhuis, Plesmanlaan 121, 1066 CX Amsterdam. epm.jansen@nki.nl
authors.forename: E P M
authors.initials: EP
authors.lastname: Jansen
authors.forename: H
authors.initials: H
authors.lastname: Boot
authors.forename: A
authors.initials: A
authors.lastname: Cats
authors.forename: F
authors.initials: F
authors.lastname: van Coevorden
authors.forename: F A N
authors.initials: FA
authors.lastname: Zoetmulder
authors.forename: M
authors.initials: M
authors.lastname: Verheij
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005743:Gastrectomy; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D018714:Radiotherapy, Adjuvant / Q000379:methods; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents