title: Anti-inflammatory activity of Indian black tea (Sikkim variety).
abstract: In this study, the anti-inflammatory (in reference to the cardinal signs of inflammation) and other related pharmacological activities of the hot water extract of black tea (Camellia sinensis, Sikkim variety) were evaluated along with certain standard drugs. The extract showed significant inhibitory activity against carrageenin, histamine, serotonin and prostaglandin-induced pedal inflammation. The extract inhibited exudative inflammation. The tea extract also inhibited cotton pellet-induced granuloma formation and adjuvant-induced polyarthritis. Black tea extract showed significant inhibition against glucose oxidase-mediated inflammation. The present observations establish the efficacy of this particular variety of black tea, both in the exudative and proliferative forms and as well in the chronic phase of inflammation.
authors.affiliation: Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Raja S.C. Mallick Road, Calcutta 700032, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Nag Chaudhuri
authors.forename: Sanmoy
authors.initials: S
authors.lastname: Karmakar
authors.forename: Dilip
authors.initials: D
authors.lastname: Roy
authors.forename: Siddhartah
authors.initials: S
authors.lastname: Pal
authors.forename: Mintu
authors.initials: M
authors.lastname: Pal
authors.forename: Tuhinadri
authors.initials: T
authors.lastname: Sen
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy* / Q000473:pathology; D007194:India; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012819:Sikkim; D013662:Tea
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D013662:Tea