title: Transplant graft vasculopathy: an emerging target for prevention and treatment of renal allograft dysfunction.
abstract: Maintenance of healthy endothelium is essential to vascular homeostasis, and preservation of endothelial cell function is critical for transplant allograft function. Damage of microvascular endothelial cells is now regarded as a characteristic feature of acute vascular rejection and chronic allograft nephropathy, which is an important predictor of graft loss and is often associated with transplant vasculopathy. In this review, we will discuss the role of microvascular endothelium, in renal allograft dysfunction, particularly as it relates to markers of endothelial dysfunction and endothelial repair mechanisms. We also discuss the potential for therapies targeting endothelial dysfunction and transplant graft vasculopathy.
authors.affiliation: Division of Nephrology, Ewha Women's University College of Medicine, Ewha Medical Research Center, Seoul, Korea. dhkang@ewha.ac.kr
authors.forename: Duk-Hee
authors.initials: DH
authors.lastname: Kang
authors.forename: Shin-Wook
authors.initials: SW
authors.lastname: Kang
authors.forename: Hyeon Joo
authors.initials: HJ
authors.lastname: Jeong
authors.forename: Yu Seun
authors.initials: YS
authors.lastname: Kim
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Yang
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Johnson
mesh_terms: D006801:Humans; D007668:Kidney / Q000098:blood supply*; D016030:Kidney Transplantation; D014184:Transplantation, Homologous; D014652:Vascular Diseases / Q000517:prevention & control* / Q000628:therapy*