Antihypertensive effect of gamma-amino butyric acid enriched soy products in spontaneously hypertensive rats.
The effect of gamma-amino butyric acid (GABA)-enriched soybean on blood pressure was investigated in male spontaneously hypertensive rats. Ten-week-old rats were given diets containing graded levels of GABA-enriched soybean powder for 8 weeks. The systolic blood pressure in rats fed 0.15% GABA diet was significantly lower at 1st week and maintained lower values for 4 weeks as compared with 0% GABA controls. No effect on blood pressure was found in those of 0.03 and 0.3% GABA. The results suggest that there exist appropriate dietary GABA level to get the blood pressure lowering effect.
Shizuka
F
F
Department of Living Sciences, Nagano Prefectural College, 8-49-7 Miwa, Nagano-City, 380-8525, Japan. fujikos@sonata.plala.or.jp
Kido
Y
Y
Nakazawa
T
T
Kitajima
H
H
Aizawa
C
C
Kayamura
H
H
Ichijo
N
N
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004032:Diet; D019587:Dietary Supplements; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D013025:Glycine max; D013599:Systole / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000959:Antihypertensive Agents; D005680:gamma-Aminobutyric Acid