[Effects of Shenmai Huoxue Decoction on early diabetic peripheral neuropathy in rats].
OBJECTIVE
To evaluate the effects of Shenmai Huoxue Decoction (SMHXD) on early diabetic peripheral neuropathy (DPN) in rats.


METHODS
The rats were randomly divided into 3 groups: normal group, diabetic model group and SMHXD-treated diabetic group. The diabetic rats were induced by streptozotocin (STZ) intraperitoneally. After the treatment, sensory nerve conduction velocity (SNCV) of caudal nerve was detected with evoked electromyography, and the activity of aldose reductase (AR) in erythrocytes and the concentration of endothelin (ET) in plasma were measured.


RESULTS
It was showed that the SNCV reduced significantly and the activity of AR in erythrocytes and the concentration of ET in plasma were increased significantly in diabetic group as compared with those in the normal group. The SNCV was increased, and the activity of AR in erythrocytes and the concentration of ET in plasma were improved significantly in SMHXD-treated diabetic group after the treatment.


CONCLUSIONS
The results indicate that SMHXD can alleviate the lesion of DPN in the early stage of diabetic rats.
Xue
Hong-Li
HL
Institute of Chinese Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China. xuehongli@sohu.com
Wang
Wen-Jian
WJ
Chen
Jian-Qiu
JQ
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination