Acute lymphoblastic leukemia with coexpression of CD56 and CD57: case report.
The authors present the clinical profile of a 6-year-old girl with an unusual immunophenotype of acute lymphoblastic leukemia (ALL). At the initial presentation, massive hepatosplenomegaly developed. The leukemic cells were myeloperoxidase-negative and morphologically lymphoblastic. These cells were positive for B-precursor-cell (CD10, CD19) antigens and natural killer cells (CD56, CD57). Rearrangements of both immunoglobulin heavy chain alleles and monoallelic rearrangement of T-cell receptors (TCRs)-beta and -delta genes, but not that of TCR-gamma gene, were detected, suggesting that these cells being of B-precursor origin. The patient received chemotherapy for extremely high-risk ALL with a good response. To the authors' knowledge, this is the first pediatric case describing coexpression of CD56 and CD57 on B-lineage ALL.
Matsubara
Kousaku
K
Department of Pediatrics, Nishi-Kobe Medical Center, 5-7-1 Kojidai, Nishi-ku, Kobe 651-2273, Japan. kskmatsu@s4.dion.ne.jp
Yura
Kazuo
K
Hirata
Takuya
T
Nigami
Hiroyuki
H
Harigaya
Hidekazu
H
Nozaki
Hideo
H
Fukaya
Takashi
T
Baba
Kunizo
K
D015703:Antigens, CD / Q000097:blood / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology; D019002:CD56 Antigen / Q000097:blood / Q000235:genetics*; D018959:CD57 Antigens / Q000097:blood / Q000235:genetics*; D002648:Child; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000235:genetics* / Q000276:immunology
D015703:Antigens, CD; D019002:CD56 Antigen; D018959:CD57 Antigens