Effects of salt loading on blood pressure in mice lacking the prostanoid receptor gene.
BACKGROUND
This study examined whether targeted disruption of the genes for the prostacyclin receptor (IP) or the thromboxane A2 receptor (TP) confers a susceptibility to salt-dependent hypertension.


RESULTS
Eight female IP- or TP-deficient mice were examined. Baseline systolic blood pressure (SBP) did not differ between TP(-/-) and TP(+/+), but was significantly lower in the IP(-/-) group than in the IP(+/+). With a high salt diet, SBP in IP(-/-) gradually increased. In contrast, SBP in the IP(+/+), TP(-/-), or TP(+/+) groups remained unchanged.


CONCLUSIONS
The prostacyclin receptor may participate in the maintenance of baseline BP. With salt loading, BP adaptation may take place, at least in part, via IP mediated signals.
Watanabe
Hidetsuna
H
Third Department of Internal Medicine, Fukushima Medical University, Fukushima, Japan.
Katoh
Tetsuo
T
Eiro
Masaaki
M
Iwamoto
Masaya
M
Ushikubi
Fumitaka
F
Narumiya
Shuh
S
Watanabe
Tsuyoshi
T
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D005260:Female; D006339:Heart Rate; D006579:Heterozygote; D006720:Homozygote; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D044006:Receptors, Epoprostenol / Q000172:deficiency* / Q000235:genetics*; D044244:Receptors, Thromboxane A2, Prostaglandin H2 / Q000172:deficiency* / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012982:Sodium, Dietary / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000652:urine
D044006:Receptors, Epoprostenol; D044244:Receptors, Thromboxane A2, Prostaglandin H2; D012982:Sodium, Dietary; D013929:Thromboxane B2