title: [The study of HLA-Cw polymorphism in Uygur population].
abstract: The HLA-Cw loci polymorphism in Uygur population was investigated using the PCR- sequence specific oligonucleotide probe (SSOP) method,and the genetic database on the distribution of gene frequency of the HLA-Cw loci was established. From 146 individuals of Uygur population,18 HLA-Cw alleles were detected. The gene frequency was from 0.0069 to 0.2460. The four most common alleles were HLA-Cw*04(24.60%),07(11.51%),08(10 10%),14(12.02%),and they covered 58.23% of total alleles detected from Uygur population.We have made a survey of HLA-Cw alleles frequencies in a Uygur population,with blank frequency being lowered to 0.0064. The distribution of genotype frequencies met the law of Hardy-Weinberg equilibrium by hi-square test. The frequency data can be used in forensic and paternity tests to estimate the frequency of a DNA profile in the Uygur population,transplant matching and anthropology.
authors.affiliation: National Laboratory of Forensic Sciences, Xi'an Jiaotong University, Xi'an 710061, China. zhanghb@mail.xjtu.edu.cn
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Zhang
authors.forename: Jun-Hai
authors.initials: JH
authors.lastname: Zhao
authors.forename: Jiang-Hua
authors.initials: JH
authors.lastname: Lai
authors.forename: Teng
authors.initials: T
authors.lastname: Chen
authors.forename: Sheng-Bin
authors.initials: SB
authors.lastname: Li
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Lai