title: Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.
abstract: The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
authors.affiliation: The Center for Transgene Technology and Gene Therapy, Flanders Interuniversitary Institute for Biotechnology (VIB), University of Leuven, Leuven, Belgium.
authors.forename: Xuri
authors.initials: X
authors.lastname: Li
authors.forename: Marc
authors.initials: M
authors.lastname: Tjwa
authors.forename: Lieve
authors.initials: L
authors.lastname: Moons
authors.forename: Pierre
authors.initials: P
authors.lastname: Fons
authors.forename: Agnes
authors.initials: A
authors.lastname: Noel
authors.forename: Annelii
authors.initials: A
authors.lastname: Ny
authors.forename: Jian Min
authors.initials: JM
authors.lastname: Zhou
authors.forename: Johan
authors.initials: J
authors.lastname: Lennartsson
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Aernout
authors.initials: A
authors.lastname: Luttun
authors.forename: Annica
authors.initials: A
authors.lastname: Pontén
authors.forename: Laetitia
authors.initials: L
authors.lastname: Devy
authors.forename: Ann
authors.initials: A
authors.lastname: Bouché
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Oh
authors.forename: Ann
authors.initials: A
authors.lastname: Manderveld
authors.forename: Silvia
authors.initials: S
authors.lastname: Blacher
authors.forename: David
authors.initials: D
authors.lastname: Communi
authors.forename: Pierre
authors.initials: P
authors.lastname: Savi
authors.forename: Françoise
authors.initials: F
authors.lastname: Bono
authors.forename: Mieke
authors.initials: M
authors.lastname: Dewerchin
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Foidart
authors.forename: Monica
authors.initials: M
authors.lastname: Autiero
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Herbert
authors.forename: D
authors.initials: D
authors.lastname: Collen
authors.forename: Carl-Henrik
authors.initials: CH
authors.lastname: Heldin
authors.forename: Ulf
authors.initials: U
authors.lastname: Eriksson
authors.forename: Peter
authors.initials: P
authors.lastname: Carmeliet
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D003331:Coronary Vessels / Q000166:cytology / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology* / Q000187:drug effects*; D006614:Hindlimb / Q000098:blood supply / Q000187:drug effects; D006801:Humans; D007511:Ischemia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D008222:Lymphokines; D051379:Mice; D008833:Microcirculation / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D019000:Phosphotyrosine / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects*
chemical_list: D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; C411423:platelet-derived growth factor C; D019000:Phosphotyrosine; D017479:Receptors, Platelet-Derived Growth Factor