title: [Detection and clinical significance of serum antibody to ribosomal P protein in patients with systemic lupus erythematosus].
abstract: OBJECTIVE
  To observe the positive rate and its clinical significance of serum antibody to ribosomal P protein (anti-P) in patients with systemic lupus erythematosus (SLE).
  
  
  METHODS
  Anti-P protein antibody was detected by EURO blot with synthetic full-length ribosomal proteins, and then correlation between anti-P antibody, other autoantibodies and clinical characters was analysed .
  
  
  RESULTS
  In 150 SLE patients 36 cases (24%) were positive for anti-P antibody. The incidence of renal and central nervous system lesions in anti-P antibody-positive patients was notably higher than that in anti-P antibody-negative group. The positive rate of anti-P antibody was correlated with that of anti-dsDNA, anti-Sm and anti-RNP antibodies, but had no correlation with the lesions of skin, joint, blood and liver, nor indexes of disease's activity (DAI).
  
  
  CONCLUSIONS
  There is correlation between anti-P antibody level with renal and CNS lesions in SLE patients.
authors.affiliation: Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi'an 710004, China.
authors.forename: Zhen-Biao
authors.initials: ZB
authors.lastname: Wu
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Nan
authors.initials: N
authors.lastname: Leng
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Fan
authors.forename: Hui-Qin
authors.initials: HQ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood* / Q000276:immunology*; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D007668:Kidney / Q000276:immunology / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012269:Ribosomal Proteins / Q000276:immunology*
chemical_list: D000906:Antibodies; D012269:Ribosomal Proteins