title: Cationic vectors in ocular drug delivery.
abstract: Despite extensive research in the field, the major problem in the ocular drug delivery domain still is rapid precorneal drug loss and poor corneal permeability. One of the approaches recently developed is the drug incorporation into cationic submicronic vectors which exploit the negative charges present at the corneal surface for increased residence time and penetration. This review will focus on the formulation of three main representative cationic colloids developed for ophthalmic delivery: liposomes, emulsions and nanoparticles (NP). Parameters such as choice of the vector type and size, nature of the cationic molecule, pH and ionic strength of the external phase and characteristics of the encapsulated drug will be discussed with accent on the relevance of the positive charge.
authors.affiliation: UMR CNRS 8612, School of Pharmacy, 92296 Châtenay Malabry, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Rabinovich-Guilatt
authors.forename: Patrick
authors.initials: P
authors.lastname: Couvreur
authors.forename: Gregory
authors.initials: G
authors.lastname: Lambert
authors.forename: Catherine
authors.initials: C
authors.lastname: Dubernet
mesh_terms: D000818:Animals; D002412:Cations; D003315:Cornea / Q000187:drug effects* / Q000378:metabolism; D004337:Drug Carriers / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions; D006801:Humans; D008081:Liposomes; D049329:Nanostructures; D010539:Permeability / Q000187:drug effects
chemical_list: D002412:Cations; D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes