title: The comparison of topical ibopamine 2% with tonography to identify the outflow resistance in eyes with ocular hypertension.
abstract: BACKGROUND
  To evaluate the ability of topical ibopamine 2% to detect outflow resistance by comparing it with the tonography test in eyes with ocular hypertension (OHT).
  
  
  METHODS
  62 eyes with OHT and 33 control eyes were included in this prospective study. Tonography was done manually as a standard outflow facility measurement. We used a C value of 0.18 mul/min/mm Hg or less and a P(o)/C value of 100 and above as a positive tonographic test. The ibopamine test performed on the following day was considered positive if there was an intraocular pressure (IOP) change of at least 3 mm Hg.
  
  
  RESULTS
  The sensitivity of the tonography and ibopamine tests was 69 and 53%, respectively, in eyes with OHT. The specificity of both tests was 97%. Although the sensitivity of the tonography test is higher than that of the ibopamine test, the difference between both was not statistically significant in these eyes (p = 0.409). Positive results in tonography were associated with higher IOP, while the results were not dependent on the IOP in the ibopamine test. Both tests together were positive in 33.87% (21 eyes) and negative in 11.29% (7 eyes) in 62 eyes with OHT.
  
  
  CONCLUSIONS
  This study revealed that the ibopamine provocation test can detect outflow system resistance in eyes with OHT comparable with tonography which is a traditional outflow facility measurement. Ibopamine, however, can detect the eye with outflow impairment by a different and IOP-independent way, while tonography depends on IOP.
authors.affiliation: Department of Ophthalmology, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey. ifhepsen@inonu.edu.fr
authors.forename: Ibrahim F
authors.initials: IF
authors.lastname: Hepsen
authors.forename: Harun
authors.initials: H
authors.lastname: Yilmaz
authors.forename: Ugur Can
authors.initials: UC
authors.lastname: Keskin
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D003846:Deoxyepinephrine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D018491:Dopamine Agonists / Q000008:administration & dosage; D005902:Glaucoma, Open-Angle / Q000175:diagnosis; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis*; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014065:Tonometry, Ocular
chemical_list: D018491:Dopamine Agonists; D009883:Ophthalmic Solutions; C023487:ibopamine; D003846:Deoxyepinephrine