Thiobutacin, a novel antifungal and antioomycete antibiotic from Lechevalieria aerocolonigenes.
A novel butanoic acid, thiobutacin (1), 4-(2-aminophenyl)-4-oxo-2-methylthiobutanoic acid (C11H13NO3S), was isolated from the culture broth of a soil actinomycete, Lechevalieria aerocolonigenes strain VK-A9. The structure of thiobutacin (1) was elucidated on the basis of the extensive 2D NMR spectral data including 1H-1H COSY, HMBC, HMQC, ROESY, and NOESY. Thiobutacin (1) showed antioomycete and antifungal activity against phytopathogenic Phytophthora capsici and Botrytis cinerea and the yeast Saccharomyces cerevisiae.
Lee
Jung Yeop
JY
Division of Bioscience and Technology, College of Life and Environmental Sciences, Korea University, Seoul 136-713, Korea.
Moon
Surk Sik
SS
Yun
Bong Sik
BS
Yoo
Ick Dong
ID
Hwang
Byung Kook
BK
D000192:Actinomycetales / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020171:Botrytis / Q000187:drug effects; D002087:Butyrates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D007723:Korea; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010838:Phytophthora / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D000935:Antifungal Agents; D002087:Butyrates; C497177:thiobutacin