title: Identification and characterisation of a novel splice variant of the human CB1 receptor.
abstract: Cannabinoid ligands are implicated in many physiological processes and to date two receptors have been identified. However, a growing body of evidence exists that suggests the presence of additional receptors. Whilst cloning the previously described hCB1a, we have identified a novel variant that we call hCB1b. Characterising these two splice variants demonstrates that they have a unique pharmacological profile and that their RNA's are expressed at low levels in a variety of tissues.
authors.affiliation: Department of Molecular Pharmacology, AstraZeneca R&D, Mölndal, Sweden.
authors.forename: Erik
authors.initials: E
authors.lastname: Ryberg
authors.forename: Huy Khang
authors.initials: HK
authors.lastname: Vu
authors.forename: Niklas
authors.initials: N
authors.lastname: Larsson
authors.forename: Thierry
authors.initials: T
authors.lastname: Groblewski
authors.forename: Stephan
authors.initials: S
authors.lastname: Hjorth
authors.forename: Thomas
authors.initials: T
authors.lastname: Elebring
authors.forename: Sven
authors.initials: S
authors.lastname: Sjögren
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Greasley
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001667:Binding, Competitive; D002186:Cannabinoids / Q000737:chemistry / Q000494:pharmacology; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects; D015870:Gene Expression; D015723:Gene Library; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000737:chemistry; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D002186:Cannabinoids; D008024:Ligands; D043884:Receptor, Cannabinoid, CB1; D016244:Guanosine 5'-O-(3-Thiotriphosphate)