[The role of the carboxy-terminal domain of the RNA polymerase II on coupling mRNA transcription with processing].
The carboxy-terminal domain of the largest subunit of the RNA polymerase II (CTD) is comprised of multiple repeats of a conserved heptapeptide with the consensus sequence-Tyr-Ser-Pro-Thr-Ser-Pro-Ser-. In the past decade,much attention has been payed to this specific structure. Many experiments showed that the CTD played a pivotal role in the coupling mechanism that links mRNA transcription with processing by associating with the transcriptional and processing factors. The recent advance of the structure and functions is summarized in this paper.
Han
Yu-Bo
YB
Department of Biology, Capital Normal University, Beijing 100037, China.
Zhang
Fei-Xiong
FX