[RNA-based transgene silencing: mechanism and applications].
RNA-based transgene silencing is a phenomenon that endogenous and exogenous mRNAs are degraded specifically directed by double-stranded RNA. Here we review the recent advances on its mechanism and summarize related proteins and expatiate their functions. Furthermore,we introduce the enormous potential of dsRNA as a tool in functional genomics research and practical biotechnology.
Chen
Wen
W
Biology Department, Capital Normal Universit, Beijing 100037, China.
Wang
Dong
D
He
Yi-Kun
YK