title: Total synthesis of the Fusarium toxin equisetin.
abstract: A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels-Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted gamma,delta-unsaturated beta-ketothioester.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Lisa T
authors.initials: LT
authors.lastname: Burke
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Dixon
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Félix
authors.initials: F
authors.lastname: Rodríguez
mesh_terms: D005670:Fusarium / Q000737:chemistry*; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes; C024509:equisetin