[Recent researches on the responses of fibroblasts exposed to cyclic mechanical stretching in vitro].
Recently, in vitro dynamical cell-culture has been drawing more and more attention from researchers in the areas of tissue engineer, and a series of researches have demonstrated that cyclic mechanical stretching has significant effects on the cell proliferation, differentiation, and on the cell alignment on scaffold, as well as on the synthesis of extracellular matrix, cytokines, and matrix metalloproteinases (MMPs). By focusing on reviewing the culture of several kinds of fibroblasts in vitro, we learned that these cellular responses mentioned above induced by cyclic mechanical stretching were tested by many precisely designed experiments, and assumed that cyclic mechanical stretching, if applied properly, would contribute significantly to our purpose of constructing more sophisticated tissue-engineered tendon and ligament.
Liang
Kailu
K
Department of Orthopedic Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
Qin
Tingwu
T
Yang
Zhiming
Z
D002454:Cell Differentiation; D049109:Cell Proliferation; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D010507:Periodicity; D033081:Shear Strength; D013314:Stress, Mechanical; D023822:Tissue Engineering
D020782:Matrix Metalloproteinases