title: The cytological spectrum of chronic pancreatitis.
abstract: Chronic pancreatitis (CP) refers to a spectrum of changes generally seen after repeated injury that ranges histologically from mild fibrosis to extensive fibroinflammatory replacement of acinar tissue with accumulation of calcific debris. Because CP can share clinical and radiological features with malignancy, it often is sampled by fine-needle aspiration (FNA). The cytology files at Hennepin County Medical Center (HCMC) were searched for 20 consecutive cases of CP sampled by FNA. Clinical data and cytological findings were recorded. A spectrum of cytological findings typifies aspirates of CP. In most cases, mixed inflammation with debris and calcific material is present. Often, ductal cells are present and at most show mild atypia but generally appear organized. Often, fibrotic acinar tissue also is present while definitive islets are identified only rarely. Although these cytological findings were consistent with CP, 3 of 17 patients with follow-up were found to have pancreatic ductal adenocarcinoma.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Virginia, Charlottesville, Virginia 22908, USA. edstelow@yahoo.com
authors.forename: Edward B
authors.initials: EB
authors.lastname: Stelow
authors.forename: Ricardo H
authors.initials: RH
authors.lastname: Bardales
authors.forename: Rebecca
authors.initials: R
authors.lastname: Lai
authors.forename: Shawn
authors.initials: S
authors.lastname: Mallery
authors.forename: Bradley M
authors.initials: BM
authors.lastname: Linzie
authors.forename: Gretchen S
authors.initials: GS
authors.lastname: Crary
authors.forename: Michael W
authors.initials: MW
authors.lastname: Stanley
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D044963:Biopsy, Fine-Needle; D002114:Calcinosis; D002908:Chronic Disease; D005260:Female; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D008297:Male; D010183:Pancreatic Ducts / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000473:pathology; D010195:Pancreatitis / Q000473:pathology*