title: Optimizing transport of metabolites through large channels: molecular sieves with and without binding.
abstract: Using a diffusion model of molecules moving through a pore, we rationalize why biological channels have an affinity for the molecules they have evolved to translocate.
authors.affiliation: Mathematical and Statistical Computing Laboratory, Division of Bioscience, Center for Information Technology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Berezhkovskii
authors.forename: Sergey M
authors.initials: SM
authors.lastname: Bezrukov
mesh_terms: D001692:Biological Transport / Q000502:physiology; D001704:Biopolymers / Q000737:chemistry* / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry* / Q000502:physiology; D002463:Cell Membrane Permeability; D003198:Computer Simulation; D004058:Diffusion; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000737:chemistry* / Q000502:physiology; D008954:Models, Biological; D008956:Models, Chemical; D016062:Porosity
chemical_list: D001704:Biopolymers; D007473:Ion Channels