title: MR imaging of renal cell carcinoma: its role in determining cell type.
abstract: Chemical shift gradient-echo MR imaging (CSI) can detect a small amount of fat as signal loss on opposed-phase images as compared with in-phase images. Cytoplasmic fat in clear cell renal cell carcinoma (RCC) or interstitial histiocytic fat in papillary cell RCC can be successfully demonstrated by this technique. T2*-weighted gradient-echo or echo-planar MR imaging can detect local susceptibility, for example, due to cytoplasmic or interstitial histiocytic hemosiderin deposition in papillary cell RCC. CSI can also show this focal susceptibility as excessive signal loss on in-phase images as compared with opposed-phase images. MR imaging can thus help predict the cell types (clear cell and papillary cell) of RCC. These findings may be important in the decision-making process in the management of patients with suspected RCC, particularly those who are not indicated for radical surgery.
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Yoshimitsu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Irie
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tajima
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nishie
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Asayama
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hirakawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kakihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D002292:Carcinoma, Renal Cell / Q000145:classification / Q000473:pathology*; D003593:Cytoplasm / Q000473:pathology; D017352:Echo-Planar Imaging; D006485:Hemosiderin / Q000032:analysis; D006801:Humans; D007089:Image Enhancement; D007680:Kidney Neoplasms / Q000145:classification / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods
chemical_list: D006485:Hemosiderin