title: Pediatric EBV-positive T-cell/histiocyte-rich large B-cell lymphoma with clonal cells in the bone marrow without overt involvement.
abstract: T-cell/histiocyte-rich large B-cell lymphoma (TCHRLBCL) is a variant of large B-cell lymphoma only rarely encountered in children. Here we report the case of an 8-year-old African American boy with Epstein-Barr virus (EBV)-positive TCHRLBCL who initially presented with right submandibular, anterior cervical and supraclavicular lymphadenopathy. Cytogenetic analysis of the lymph node revealed a near-triploid karyotype with complex chromosomal aberrations. Although morphologically the bone marrow was normal, the same cytogenetically abnormal clone was detected. The patient responded to chemotherapy with CHOP (doxorubicin, cyclophosphamide, vincristine and prednisone) therapy, with disappearance of the abnormal clone from the bone marrow. The patient remains in remission 26 months after the initial diagnosis.
authors.affiliation: Pediatric Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan 48201-2196, USA.
authors.forename: Bülent
authors.initials: B
authors.lastname: Ozgönenel
authors.forename: Süreyya
authors.initials: S
authors.lastname: Savaşan
authors.forename: Raja
authors.initials: R
authors.lastname: Rabah
authors.forename: Anwar N
authors.initials: AN
authors.lastname: Mohamed
authors.forename: Barbara
authors.initials: B
authors.lastname: Cushing
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology*; D002648:Child; D002869:Chromosome Aberrations; D002999:Clone Cells / Q000473:pathology*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000473:pathology*; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D008297:Male; D012074:Remission Induction; D013601:T-Lymphocytes / Q000473:pathology*