Inflammatory response, reactive oxygen species, programmed (necrotic-like and apoptotic) cell death and cancer.
In this short review we attempt to establish and/or strengthen connections between clinical, inflammatory manifestation of cancer, inflammatory processes driven by lipoxy-metabolites and their contribution to immortalized phenotype and apoptosis inhibition. Particularly the resemblance between symptoms of inflammation and signs associated with cancer chemotherapy and/or cytokine therapy is illustrated. In this context the role of apoptosis and necrosis in inflammation as well as the role of RedOx processes and lipid-oxidizing enzymes particularly cyclooxygenase-2 (COX-2) and also to lesser extend the 5-lipooxygenase (5-LOX) is highlighted. The multitude of biological effects of reactive oxygen species is shortly summarized and some aspects of it are being discussed in greater detail. Apoptotic cell death is discussed in the context of the "resolve-phase" of an inflammatory response. The disturbance of apoptosis is mainly deliberated in the framework of insufficient removal of immuno-effector cells that may cause autoimmunity. The role of COX-2 in apoptosis resistance is being highlighted mainly in the context of malignant transformation. The mechanism of cell death (apoptotic or necrotic) and its influence on the immune system and potential benefits of necrotic cell death induction during cancer chemotherapy is indicated.
Johar
D
D
Manitoba Institute of Cell Biology, Winnipeg, Canada.
Roth
J C
JC
Bay
G H
GH
Walker
J N
JN
Kroczak
T J
TJ
Los
M
M
D017209:Apoptosis; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism*; D020169:Caspases / Q000378:metabolism; D051546:Cyclooxygenase 2; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000503:physiopathology; D008565:Membrane Proteins; D009336:Necrosis / Q000378:metabolism* / Q000503:physiopathology; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D008565:Membrane Proteins; D017382:Reactive Oxygen Species; D001094:Arachidonate 5-Lipoxygenase; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D020169:Caspases