Macrophage biology in the Anx-A1-/- mouse.
Historical data suggested that a soluble protein, since identified as annexin-A1 (Anx-A1) was released from macrophages following glucocorticoid stimulation and could modulate eicosanoid production and other functions of these cells. Here, we review some recent findings using a line of Anx-A1(-/-) mice to explore the impact of Anx-A1 gene deletion on macrophage biology. The absence of Anx-A1 selectively alters phagocytic capacity of rodent resident peritoneal macrophages apparently through changes in surface adhesion molecule expression. Anx-A1 is also apparently important in the tonic down-regulation of other macrophage functions such as COX-2 induction, PGE(2) release and the production of reactive oxygen species.
Yona
S
S
Biochemical Pharmacology Group, William Harvey Research Institute, Queen Mary Charterhouse Square, University of London, London EC1M 6BQ, UK.
Ward
Barbara
B
Buckingham
Julia C
JC
Perretti
M
M
Flower
R J
RJ
D000818:Animals; D017305:Annexin A1 / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000235:genetics; D015777:Eicosanoids / Q000096:biosynthesis; D008264:Macrophages / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D010587:Phagocytosis
D017305:Annexin A1; D015815:Cell Adhesion Molecules; D015777:Eicosanoids