title: Interaction of polypyridyl ruthenium (II) complex containing asymmetric ligand with DNA.
abstract: A novel asymmetric bidentate ruthenium (II) complex, [Ru(bpy)(2)(PYNI)](2+) (bpy=2,2'-bipyridine, PYNI=2-(2'-pyridyl)naphthoimidazole), has been synthesized and characterized by elemental analysis, ES-MS (electrospray mass spectra) and (1)H NMR. The electrochemical behaviors of this complex were studied by cyclic voltammetry. DNA interaction studies suggest that [Ru(bpy)(2)(PYNI)](2+) binds to calf thymus DNA (CT-DNA) in an intercalative mode. Interestingly, this new Ru(II) complex has also been found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation.
authors.affiliation: Department of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China.
authors.forename: Yun-Jun
authors.initials: YJ
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Chao
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Tan
authors.forename: Yi-Xian
authors.initials: YX
authors.lastname: Yuan
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.forename: Liang-Nian
authors.initials: LN
authors.lastname: Ji
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000187:drug effects*; D066298:In Vitro Techniques; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D049449:Luminescence; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010777:Photochemistry; D010957:Plasmids / Q000187:drug effects; D012428:Ruthenium; D021241:Spectrometry, Mass, Electrospray Ionization; D013053:Spectrophotometry; D013816:Thermodynamics; D014783:Viscosity
chemical_list: D007364:Intercalating Agents; D008024:Ligands; D009942:Organometallic Compounds; D012428:Ruthenium; D004247:DNA