6-hydroxy-4-en-3-one sterols from the marine sponge Iotrochoto birotulata.
Five sterols with a nucleus skeleton of 6-hydroxy-4-en-3-one, namely cholesta-6beta-hydroxy-4-en-3-one (1), ergosta-6beta-hydroxy-4,24(28)-dien-3-one (2), ergosta-6alpha-hydroxy-4,24(28)-dien-3-one (3), ergosta-6alpha-hydroxy-4,22-E-dien-3-one (4), and ergosta-28-methyl-6beta-hydroxy-4,24(28)-dien-3-one (5) have been isolated from the marine sponge Iotrochoto birotulata, collected from the southern China sea. Sterols 2-4 are new compounds, and 1 has been isolated from marine organisms for the first time. The structures have been elucidated on the basis of extensive spectroscopic and chemical properties.
Li
Li-Ya
LY
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China.
Deng
Zhi-Wei
ZW
Fu
Hong-Zheng
HZ
Li
Jun
J
Lin
Wen-Han
WH
Proksch
Peter
P
D000818:Animals; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification*
D013261:Sterols