Synthesis and pharmacological activity of 4-(4'-(chlorophenyl)-4-hydroxypiperidine) derivatives.
A new series of 4-(4'-chlorophenyl)-4-hydroxypiperidine derivatives (2-5), substituted at nitrogen, were synthesized and tested as potential analgesic compounds as well as evaluated for their effect on hypotensive activity. Results showed that all the derivatives exhibit significant analgesic activity in male Wistar rats at a dose of 50 mg/kg of body weight after intramuscular injection, when tested by thermal stimuli (tail flick test). Pethidine was used as reference drug. Compounds 2, 3 and 5 produced reduction in blood pressure in normotensive rat.
Saify
Zafar Saeed
ZS
HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi, Pakistan. hassaan2@super.net.pk
Mushtaq
Nousheen
N
Khan
Khalid Mohammed
KM
Perveen
Shahnaz
S
Shah
Syed Tasadaque Ali
ST
Abdel-Jalil
Raid Jamil
RJ
Fecker
Miriam
M
Voelter
Wolfgang
W
D000818:Animals; D008297:Male; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010880:Piperidines