Ischemia/reperfusion injury at the intersection with cell death.
Since its description in myocardial ischemia/reperfusion a decade ago, the process of programmed cell death has been the subject of intense study by investigators in cardiology. Comparison with other systems has identified parallels as well as features that are unique to the heart. An understanding of the molecular events that transpire during ischemia should inform our analysis of the relevant pathways of cell death. The intersection of ischemic preconditioning and cell death can provide illumination to both signal transduction pathways.
Logue
Susan E
SE
National University of Ireland, Galway, Ireland.
Gustafsson
Asa B
AB
Samali
Afshin
A
Gottlieb
Roberta A
RA
D000818:Animals; D002118:Calcium / Q000378:metabolism; D016923:Cell Death; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction
D017382:Reactive Oxygen Species; D002118:Calcium