Oral vitamin C ameliorates smoking-induced arterial wall stiffness in healthy volunteers.
We have investigated whether the oral administration of vitamin C could prevent smoking-induced acceleration of arterial stiffness in healthy volunteers. Subjects were pretreated with 2 g vitamin C and their heart rate (HR), mean blood pressure (MBP), and brachial-ankle pulse wave velocity (baPWV) were measured before and after smoking. Smoking significantly increased the HR, MBP, baPWV (13, 6.4, 7.0%). Vitamin C treatment significantly reduced the smoking-induced elevation in baPWV at 0 min (- 58.5%, p = 0.0002) without affecting HR or MBP. These findings suggest that oral vitamin C treatment prevents smoking-induced acceleration in arterial stiffness through reducing endothelial dysfunction.
Katayama
Yasuyuki
Y
Department of Internal Medicine, Japan Self Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan. yasukatayama@dream.com
Shige
Hideki
H
Yamamoto
Akemi
A
Hirata
Fumihiko
F
Yasuda
Hiroko
H
D001158:Arteries / Q000503:physiopathology*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D001794:Blood Pressure; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012907:Smoking / Q000009:adverse effects*
D001205:Ascorbic Acid