Effects of combination of Caiapo with other plant-derived substance on anti-diabetic efficacy in KK-Ay mice.
B. Ludvik et al., have recently shown the effect of Caiapo (Ipomoea batatas L.) on reducing fasting blood glucose and insulin resistance in type-2 diabetic patients. It, however, was required 2-4 weeks after the single administration of Caiapo. The present study aimed to determine if the combination therapy of Caiapo with a mulberry leaf powder, which inhibits alpha-glucosidase, or with a loquat leaf extract, which shows an insulin-like effect, could make it possible to enhance the antidiabetic activities of Caiapo, and to shorten the time necessary for the inhibition of increasing blood glucose levels. A mixture of the pulverized tuber of Caiapo (357 mg/kg) and the mulberry leaf powder (143 mg/kg), or a mixture of the pulverized skin of Caiapo (194 mg/kg) and the powdered loquat leaf extract (6 mg/kg) was orally administered to 6 weeks-old male KK-Ay mice for 28 days and the glucose loading test was conducted every 7 days. In the glucose loading test after one week feeding, a reduction in blood glucose concentration after 60 minutes of the administration of glucose was observed in both mixture groups against the control group (p < 0.05) in the case of Caiapo only, similar delayed effects were seen in 2-3 weeks after feeding.
Sakuramata
Yasuhide
Y
Research and Development, Fuji Sangyo Co., Ltd., 1301 Tamura-cho, Marugame, Kagawa 763-8603, Japan. sakuramata@fuji-sangyo.co.jp
Oe
Hiromi
H
Kusano
Syuichi
S
Aki
Osami
O
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004195:Disease Models, Animal; D005951:Glucose Tolerance Test; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007333:Insulin Resistance; D027741:Ipomoea; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D018515:Plant Leaves; D018517:Plant Roots
D001786:Blood Glucose; D007004:Hypoglycemic Agents