[Effect of bone marrow transplantation conditioning regimen on thyroid and adrenocortical functions in patients with blood diseases].
OBJECTIVE
In order to investigate the life quality of patients with hematological diseases after bone marrow transplantation (BMT).


METHODS
Pituitary-thyroid and adrenocortical function were de tected in 29 patients with hematological diseases before and after BMT.


RESULTS
All patients had normal thyroid and adrenocortical functions before BMT. As compared with pre-BMT,the median serum TSH levels were significantly increased at 3, 6, 12 (P<0.01), 24-60 (P<0.05) months post-BMT. The adrenocortical function had no change in all patients, and thyroid dysfunction were found in 6 of 24 patients detected at a median time of 6 month post-BMT. Five of the 6 thyroid dysfuntion patients developed hypothyroidism, and one hyperthyroidism.


CONCLUSIONS
There was little effect of conditioning regimen on adrenocortical function, while thyroid dysfunction was common after BMT. Long term follow up on thyroid function in patients after BMT is necessary.
Feng
S
S
Institute of Hematology, Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.
Yan
W
W
Han
M
M
Qiu
L
L
Yan
Y
Y
Han
J
J
D000293:Adolescent; D000302:Adrenal Cortex / Q000503:physiopathology*; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006402:Hematologic Diseases / Q000097:blood / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000503:physiopathology*; D019172:Transplantation Conditioning / Q000009:adverse effects*; D055815:Young Adult