[The relationship of DNA methylation and histone methylation].
In and out of the eukaryotic genomes, there exist many covalent modifications, of which are the methylation of DNA and histones, and they are both involved in genes silencing, in which the methylation of DNA and H3K9 are synergistic, but the methylation of H3K4 is antagonistic to them. The recent studies showed that these two methylations are correlated, that is, DNA methylation is dependent on the methylation of H3K9. However, the relationship of these two methylations is more complicated in mammals than in lower eukaryotons and plants.
Li
Jian-Xu
JX
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210 095, China.
Liu
Hong-Lin
HL
D000818:Animals; D019175:DNA Methylation; D020868:Gene Silencing; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008745:Methylation
D006657:Histones; D011495:Histone-Lysine N-Methyltransferase