Distinct striatal regions support movement selection, preparation and execution.
The aim of this study was to determine whether distinct striatal territories are specifically involved during the selection, preparation and execution of a movement. Nine volunteers were studied using fMRI at 3 T. Subjects were presented with visual stimuli instructing them to prepare during a variable delay and then execute a button press with either the left or the right hand. The side of the movement was either freely selected by the subject (free selection) or specified by the instruction cue (preparation). Movement selection, preparation and execution were associated with activation in the caudate nucleus, the anterior and the posterior parts of the putamen, respectively. These results suggest that these three aspects of movement are represented within distinct basal ganglia regions.
Gerardin
Emmanuel
E
Inserm U610 2Inserm U289, Hôpital de la Salpêtrière, Paris, France.
Pochon
Jean-Baptiste
JB
Poline
Jean-Baptiste
JB
Tremblay
Léon
L
Van de Moortele
Pierre-François
PF
Levy
Richard
R
Dubois
Bruno
B
Le Bihan
Denis
D
Lehéricy
Stéphane
S
D000328:Adult; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D000077463:Carbamide Peroxide; D003657:Decision Making / Q000502:physiology*; D004338:Drug Combinations; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009068:Movement / Q000502:physiology*; D010545:Peroxides / Q000097:blood; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D014508:Urea / Q000031:analogs & derivatives* / Q000097:blood
D004338:Drug Combinations; D010545:Peroxides; D000077463:Carbamide Peroxide; D014508:Urea