title: Detection of herpesvirus-6A in a case of subacute cerebellitis and myoclonic dystonia.
abstract: This is a case study of a child who developed roseola infantum first, then varicella, and was later affected by acute cerebellar syndrome, severe truncal ataxia, and myoclonic dystonia. Human herpesvirus 6 (HHV-6) A and B were detected in the cerebrospinal fluid (CSF) and peripheral blood, respectively, upon ataxia onset. The intricacy of this case suggests multifaceted conclusions ranging from the need for a multidirectional approach to neurological diseases, to confirmation of a more pronounced neurotropism of HHV-6A and a possible role of viruses in myoclonic dystonia syndrome, although this last hypothesis should be confirmed by larger studies.
authors.affiliation: Department of Biomedical Science and Technology, University of Milan, Milan, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Borghi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Pagani
authors.forename: Roberta
authors.initials: R
authors.lastname: Mancuso
authors.forename: Serena
authors.initials: S
authors.lastname: Delbue
authors.forename: Marilena
authors.initials: M
authors.lastname: Valli
authors.forename: Romina
authors.initials: R
authors.lastname: Mazziotti
authors.forename: Lucio
authors.initials: L
authors.lastname: Giordano
authors.forename: Roberto
authors.initials: R
authors.lastname: Micheli
authors.forename: Pasquale
authors.initials: P
authors.lastname: Ferrante
mesh_terms: D002526:Cerebellar Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000821:virology*; D002644:Chickenpox / Q000150:complications / Q000821:virology; D002675:Child, Preschool; D004421:Dystonia / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications / Q000821:virology*; D005077:Exanthema Subitum / Q000150:complications / Q000821:virology; D005260:Female; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D009207:Myoclonus / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications / Q000821:virology*; D019349:Roseolovirus Infections / Q000150:complications / Q000821:virology