title: [Tropical spastic paraparesis and HTLV-I associated myelopathy in infancy. A case report and review of the literature].
abstract: BACKGROUND
  HTLV-I associated myelopathy is characterised by a clinical picture of slowly progressive spastic paraparesis that generally presents when the patient is at an age somewhere between his or her thirties and sixties; few cases have been reported involving children. It is a pathology that is prevalent in tropical regions that are endemic for HTLV-I (southern Japan, the Caribbean, Central and South America, and some areas of Africa).
  
  
  METHODS
  The authors report the case of a 9-year-old child from Guinea who was admitted to the Paediatric Neurology Unit in the Hospital de Santa Maria with a two-year-old clinical history of spastic paraparesis. Computerised tomography and magnetic resonance imaging did not show any alterations to the spinal cord. Somatosensory evoked potentials revealed a lesion in the posterior dorsolumbar spinal cord. The exclusion of other (infectious, metabolic and demyelinating) pathologies and the confirmation of infection by HTLV-I (by means of PCR) led to a diagnosis of myelopathy associated to this virus. Therapy was established with interferon alfa, but no appreciable significant improvement was observed.
  
  
  CONCLUSIONS
  This case stands out because of the uncommonness of this pathology at the paediatric age. We review the most relevant aspects of this disorder at the earliest ages, above all with regard to its epidemiology, transmission, clinical symptoms and complementary diagnostic examinations. Known therapeutic options (corticoids, interferon alfa, antiretroviral agents, among others) and prognosis are also discussed.
authors.affiliation: Clínica Universitaria de Pediatría, Hospital de Santa María, Lisboa, Portugal. sofiaquintas@clix.pt
authors.forename: S
authors.initials: S
authors.lastname: Quintas
authors.forename: T
authors.initials: T
authors.lastname: Moreno
authors.forename: N
authors.initials: N
authors.lastname: Lobo-Antunes
authors.forename: A
authors.initials: A
authors.lastname: Levy-Gomes
mesh_terms: D044383:Black People; D002648:Child; D015490:HTLV-I Infections / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D015493:Paraparesis, Tropical Spastic / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology