Structure of tyroscherin, an antitumor antibiotic against IGF-1-dependent cells from Pseudallescheria sp.
An antitumor antibiotic, tyroscherin, was isolated from the culture of a fungus identified as Pseudallescheria sp. The structure of tyroscherin including the absolute stereochemistry was determined as shown in Fig. 1 by NMR and degradation studies. Tyroscherin selectively inhibited IGF-1-dependent growth of MCF-7 human breast cancer cells with an IC50 of 9.7 ng/ml.
Hayakawa
Yoichi
Y
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2461, Yamazaki, Noda-shi, Chiba 278-8510, Japan. hykw@rs.noda.tus.ac.jp
Yamashita
Tomoki
T
Mori
Toshiya
T
Nagai
Koji
K
Shin-Ya
Kazuo
K
Watanabe
Hidenori
H
D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004837:Epinephrine / Q000031:analogs & derivatives* / Q000737:chemistry*; D005233:Fatty Alcohols / Q000737:chemistry*; D005285:Fermentation; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D011541:Pseudallescheria / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D005233:Fatty Alcohols; C495800:tyroscherin; D007334:Insulin-Like Growth Factor I; D004837:Epinephrine