title: C-erb-B2 and Bcl-xl protein expression in Barrett's oesophagus in correlation with morphological parameters.
abstract: The aim of the study was to evaluate the correlation of c-erb-b2 and Bcl-xl expression in biopsy specimens of Barrett's oesophagus from 44 patients with morphological features. The examined group was subdivided into: negative for dysplasia, indefinite for dysplasia, positive for dysplasia-low grade, and adenocarcinoma with high grade dysplasia. Positive c-erb-B2 staining was found in 34.1% and Bcl-xl protein expression was observed in 96.9% of BE. The results showed increased c-erb-B2 and Bcl-xl protein expressions with progressive grades of dysplasia to adenocarcinoma. In conclusion, an evaluation of c-erb-B2 and Bcl-xl expression can be useful for the histopatologic diagnosis of BE and correct interpretation of dysplasia.
authors.affiliation: Department of Pathology, Medical University of Bialystok, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Barwijuk-Machała
authors.forename: J
authors.initials: J
authors.lastname: Reszeć
authors.forename: A
authors.initials: A
authors.lastname: Kemona
authors.forename: M
authors.initials: M
authors.lastname: Sobaniec-Lotowska
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D017209:Apoptosis; D001471:Barrett Esophagus / Q000473:pathology*; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D012189:Retrospective Studies; D051020:bcl-X Protein
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D018719:Erb-b2 Receptor Tyrosine Kinases; D051020:bcl-X Protein; C494811:BCL2L1 protein, human