Scabrolides E-G, three new norditerpenoids from the soft coral Sinularia scabra.
Three new norditerpenoids, scabrolides E-G (1-3), and dissectolide A (4) have been isolated from the organic extract of a Taiwanese soft coral Sinularia scabra. The structures of 1-3 were determined on the basis of extensive spectroscopic analyses and by comparison of their spectral data with those of the known related metabolites. Metabolite 1 was found to exhibit significant cytotoxicity against the growth of Hepa59T/VGH and KB cell lines.
Ahmed
Atallah F
AF
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.
Su
Jui-Hsin
JH
Kuo
Yao-Haur
YH
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013624:Taiwan
D004224:Diterpenes; C497185:dissectolide A; C497178:scabrolide E; C497179:scabrolide F; C497180:scabrolide G