Enzymatic synthesis of D-glucosaminic acid from D-glucosamine.
D-glucosaminic acid (2-amino-2-deoxy-D-gluconic acid), a component of bacterial lipopolysaccharides and a chiral synthon, is easily prepared on a multigram scale by air oxidation of D-glucosamine (2-amino-2-deoxy-D-glucose) catalysed by glucose oxidase.
Pezzotti
Fabio
F
Laboratoire de Chimie Bioorganique et Bioinorganique, UMR 8124, ICMMO, Université Paris-Sud, 91405 Orsay, France.
Therisod
Hélène
H
Therisod
Michel
M
D001234:Aspergillus niger / Q000201:enzymology; D002374:Catalase / Q000378:metabolism; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000096:biosynthesis* / Q000737:chemistry / Q000378:metabolism*; D005949:Glucose Oxidase / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D010084:Oxidation-Reduction
C035547:glucosaminic acid; D005949:Glucose Oxidase; D002374:Catalase; D005944:Glucosamine