title: Preliminary results of [99mTc]OKT3 scintigraphy to evaluate acute rejection in renal transplants.
abstract: Allograft rejection can be classified as humoral or cellular mechanisms. Accurate diagnosis of acute rejection remains a formidable challenge in renal transplantation. The need to avoid unnecessary immunosuppressive therapy to treat this complication has led to a continued search for improved diagnostic methods to evaluate and identify postoperative episodes. Here we evaluated the use of [(99m)Tc]OKT3 scintigraphy to diagnose acute rejection in renal transplants. Among 22 patients undergoing renal transplant, we observed an increased [(99m)Tc]OKT3 kidney uptake with the passage of time in patients with rejecting allografts. These findings agreed with those of biopsies. We suggest the [(99m)Tc]OKT3 scans may be useful for the monitoring of renal transplants to detect acute rejection.
authors.affiliation: Universidade Federal do Rio de Janeiro, 21941-590 Rio de Janeiro, Brazil.
authors.forename: F P P
authors.initials: FP
authors.lastname: Martins
authors.forename: S A L
authors.initials: SA
authors.lastname: Souza
authors.forename: R T
authors.initials: RT
authors.lastname: Gonçalves
authors.forename: L M B
authors.initials: LM
authors.lastname: Fonseca
authors.forename: B
authors.initials: B
authors.lastname: Gutfilen
mesh_terms: D003404:Creatinine / Q000097:blood; D006084:Graft Rejection / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D016853:Muromonab-CD3 / Q000493:pharmacokinetics; D011868:Radioisotopes / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D012016:Reference Values; D015203:Reproducibility of Results; D013667:Technetium / Q000493:pharmacokinetics
chemical_list: D016853:Muromonab-CD3; D011868:Radioisotopes; D013667:Technetium; D003404:Creatinine