Effect of paracetamol on uric acid determination.
The effect of paracetamol on uric acid determination using a phosphotungstate reduction method has been investigated. The results show that apparently raised values of serum uric acid may be reported in patients receiving therapeutic levels of this drug. Levels of serum uric acid were determined over a five-hour period in three patients who had received therapeutic doses of paracetamol. The assays of serum uric acid were performed by a method based on phosphotungstate reduction and by one employing uricase. The results illustrate the problems of using the former method for clinical purposes.
Wilding
P
P
Department of Clinical Chemistry, Queen Elizabeth Medical Centre, Birmingham.
Heath
D A
DA
D000082:Acetaminophen / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use*; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects; D001322:Autoanalysis / Q000295:instrumentation / Q000379:methods*; D001965:Bromides / Q000009:adverse effects; D003975:Diazepam / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D062787:Drug Overdose; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D010084:Oxidation-Reduction; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D010772:Phosphotungstic Acid; D012720:Severity of Illness Index; D019966:Substance-Related Disorders; D013997:Time Factors; D014503:Urate Oxidase; D014527:Uric Acid / Q000097:blood*
D000927:Anticonvulsants; D001965:Bromides; D010772:Phosphotungstic Acid; D014527:Uric Acid; D000082:Acetaminophen; D010672:Phenytoin; D014503:Urate Oxidase; D003975:Diazepam; D010634:Phenobarbital