title: Effect of administrating oxytocin or prostaglandin F2alpha on characteristics of the canine ejaculate.
abstract: To test the hypothesis that male dogs treated with smooth muscle contracting drugs have an increase in the total number of spermatozoa in the ejaculate but no change in all other ejaculate characteristics, such as progressive motility of spermatozoa or percentage morphologically normal spermatozoa, dogs were treated with oxytocin or prostaglandin F2alpha (PGF2alpha) and compared to saline treatments. Semen was collected from each of the 3 dogs once every 3 to 4 d for a total of 6 collections per dog. Ten minutes before each collection, 1 of 3 injections (oxytocin 10 IU [0.5 mL], IM; PGF2alpha 2.5 mg [0.5 mL], IM; or saline 0.5 mL, IM) was administered. Compared to the saline controls, neither treatment had any significant effect on any measured variable when collected in this manner with an estrus bitch present. Therefore, the use of these drugs does not appear to be a viable treatment to increase the number of spermatozoa.
authors.affiliation: University of Minnesota, College of Veterinary Medicine, 1365 Gortner Avenue, St. Paul, Minnesota 55108, USA. anne@upriverragdolls.com
authors.forename: Anne M
authors.initials: AM
authors.lastname: Traas
authors.forename: Margaret V Root
authors.initials: MV
authors.lastname: Kustritz
mesh_terms: D000818:Animals; D015237:Dinoprost / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D004542:Ejaculation / Q000187:drug effects; D007273:Injections, Intramuscular / Q000662:veterinary; D007315:Insemination, Artificial / Q000379:methods / Q000662:veterinary; D008297:Male; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology
chemical_list: D010121:Oxytocin; D015237:Dinoprost