Molecular mechanisms involved in the pathogenesis of septic shock.
Pathogenesis of the development of sepsis is highly complex and has been the object of study for many years. The inflammatory phenomena underlying septic shock are described in this review, as well as the enzymes and genes involved in the cellular activation that precedes this condition. The most important molecular aspects are discussed, ranging from the cytokines involved and their respective transduction pathways to the cellular mechanisms related to accelerated catabolism and multi-organic failure.
López-Bojórquez
Lucia Nikolaia
LN
Departamento de Biología Celular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico, D.F., Mexico. llopez@ifc.unam.mx
Dehesa
Alejandro Zentella
AZ
Reyes-Terán
Gustavo
G
D016207:Cytokines / Q000378:metabolism; D006439:Hemodynamics; D006801:Humans; D007107:Immune System / Q000502:physiology; D008070:Lipopolysaccharides / Q000276:immunology; D008262:Macrophage Activation; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism; D012772:Shock, Septic / Q000209:etiology* / Q000276:immunology / Q000401:mortality / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology; D013927:Thrombosis; D051193:Toll-Like Receptors
D016207:Cytokines; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors