Cerebral neurocytoma without ganglion cell differentiation.
Neurocytomas are rare neuronal tumours, and are defined as tumours comprising cells with neuronal differentiation; they commonly arise in the ventricles. We report a case of a cerebral neurocytoma in a young man who presented with hemiparesis. The tumour was a radiologically a well-circumscribed large cyst with solid mass; the histopathology showed a well-differentiated lesion comprising uniform, round cells with perinuclear halos in a neuropil background, and immunohistochemically positive for neuronal markers (synaptophysin, neuron-specific enolase and neurofilaments). We suggest that cerebral neurocytomas should be considered among the uncommon causes of a large intra-axial cystic mass with a solid component in young adults.
Kim
J-H
JH
Department of Neurosurgery, School of Medicine, Korea University, Gurodong-gil, Guro-gu, Seoul, Korea.
Park
K-J
KJ
Lee
J-H
JH
Chung
H-S
HS
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D002454:Cell Differentiation / Q000502:physiology; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D020547:Lateral Ventricles / Q000473:pathology; D008297:Male; D009069:Movement Disorders / Q000209:etiology; D018365:Neoplasm, Residual; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D018306:Neurocytoma / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D016900:Neurofilament Proteins / Q000378:metabolism; D009474:Neurons / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011237:Predictive Value of Tests; D016708:Synaptophysin / Q000378:metabolism
D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D016900:Neurofilament Proteins; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase