[Antimicrobial susceptibility testing of clinical isolates of Haemophilus influenzae derived from Japanese children].
We examined the antimicrobial susceptibility testing of 1,024 Haemophilus influenzae isolates recovered from Japanese children. Percent distribution of beta-lactamase-negative ampicillin (ABPC)--resistant strain (BLNAR; ABPC-MIC > or = 4 microg/ml) was 15.0%. Prevalence of BLNAR increased remarkably from 12.7 to 22.1% in recent 4 years. Furthermore, the frequency of highly resistant strains (ABPC-MIC > or = 8 microg/ml) increased from 28.6 to 56.9% among BLNAR. Decreased susceptibility for cephems was observed in non-BLNAR strains including serotype b strain isolated from the cerebrospinal fluid.
Hoshino
Tadashi
T
Division of Infectious Diseases, Chiba Children's Hospital.
Sudo
Fusayo
F
Sawada
Kyoko
K
Sueyoshi
Saori
S
Nakamura
Akira
A
D000667:Ampicillin / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male
D000667:Ampicillin