Interrelationship between macrophage IL-12, IL-10 and NO secretion in expression of their tumoricidal activity.
Peritoneal macrophage activity in the secretion of IL-12, IL-10, NO and interrelationship between these substances in hamster bearing two lines of transplantable melanomas with different biological properties were studied. It has been found that these macrophages lack of homogenous reactivity in the secretion of studied substances. Melanotic melanoma line evoked moderate increase secretion of all above mentioned substances, whereas amelanotic melanoma line, tumor with higher immunogenicity, tumorogenicity and with shorter survival time of animals induced considerably increase of IL-12 and NO with prominent decrease of IL-10 secretion. Results allow to assume that macrophage secretory activity and interrelationship between these substances is not uniform in two lines of the same neoplasma and that it depends on tumor biological properties. Such observation seems to be useful in case of tumor cytokine immunotherapy.
Kozłowska
K
K
Department of Embryology, Medical University, 80-211 Gdansk, Poland. cecylia@amedec.amg.gda.pl
Cichorek
M
M
Zareczna
M
M
D000818:Animals; D006224:Cricetinae; D016753:Interleukin-10 / Q000378:metabolism*; D018664:Interleukin-12 / Q000378:metabolism*; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008297:Male; D008546:Melanoma, Experimental / Q000378:metabolism* / Q000473:pathology; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D009569:Nitric Oxide / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured
D016753:Interleukin-10; D018664:Interleukin-12; D009569:Nitric Oxide