title: Absence of cholinergic deficits in "pure" vascular dementia.
abstract: Choline acetyltransferase in temporal cortex was evaluated as a marker of cholinergic function in autopsied dementia cases (9 vascular dementia [VaD] cases, 12 "mixed" VaD and Alzheimer disease [AD] cases, 10 AD cases, 12 control subjects). Patients with AD (t = 2.5, p = 0.02) and "mixed" VaD and AD (t = 3.8, p = 0.001) had greater cholinergic deficits than age-matched control subjects and patients with "pure" VaD. The absence of cholinergic deficits in "pure" VaD may be relevant to the pharmacologic treatment of these patients.
authors.affiliation: Newcastle General Hospital, MRC Bldg., Westgate Rd., Newcastle upon Tyne, NE4 6BE, UK. e.k.perry@ncl.ac.uk
authors.forename: E
authors.initials: E
authors.lastname: Perry
authors.forename: I
authors.initials: I
authors.lastname: Ziabreva
authors.forename: R
authors.initials: R
authors.lastname: Perry
authors.forename: D
authors.initials: D
authors.lastname: Aarsland
authors.forename: C
authors.initials: C
authors.lastname: Ballard
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000172:deficiency* / Q000502:physiology; D015140:Dementia, Vascular / Q000150:complications / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D013702:Temporal Lobe / Q000201:enzymology
chemical_list: D002795:Choline O-Acetyltransferase