title: Effect of Ruta graveolens L. on pregnant mice.
abstract: Ruta graveolens L. is used in many countries, including Brazil, as an abortifacient. To determine its effect on pregnancy, the lyophilized hydroalcoholic extract of its aerial parts was administered orally at a dose of 1000 mg/kg per day to mice between the first and third day of pregnancy (DOP), between the fourth and sixth DOP or between the seventh and ninth DOP. The extract did not cause preimplantation embryonic loss or reabsorptions. Fetal death was found. Estrogenic activity was not exhibited by the extract.
authors.affiliation: Department of Morphological Sciences, Institute of Health Basic Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS90050-170, Brazil.
authors.forename: Tanise Gonçalves
authors.initials: TG
authors.lastname: de Freitas
authors.forename: Patrice Martins
authors.initials: PM
authors.lastname: Augusto
authors.forename: Tatiana
authors.initials: T
authors.lastname: Montanari
mesh_terms: D000019:Abortifacient Agents / Q000008:administration & dosage*; D000284:Administration, Oral; D000818:Animals; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D008297:Male; D051379:Mice; D010053:Ovary / Q000187:drug effects*; D048789:Phytoestrogens / Q000032:analysis; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D011247:Pregnancy; D032105:Ruta
chemical_list: D000019:Abortifacient Agents; D048789:Phytoestrogens; D010936:Plant Extracts