title: Dopamine D4 receptor exon III genotype influence on the auditory evoked novelty P3.
abstract: The functional implications of the dopamine D4 receptor gene (DRD4) exon III polymorphism and its role in the modulation of temperament and in the pathophysiology of psychiatric disorders are still a matter of debate. Based on evidence from animal studies, we hypothesised that this polymorphism is involved in the modulation of the cortical response to novelty as reflected by the auditory evoked novelty P3 event-related potential. In a sample of 46 healthy volunteers, we observed an interactive effect of DRD4 exon III genotype and the eye-blink rate, a measure of central dopaminergic activity, on the novelty P3. These findings suggest that the DRD4 exon III polymorphism influences the processing of novelty and that this influence depends on tonic dopaminergic activity.
authors.affiliation: Institute of Psychology II, Dresden University of Technology, 01062 Dresden, Germany. alexander.strobel@mailbox.tu-dresden.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Strobel
authors.forename: Stefan
authors.initials: S
authors.lastname: Debener
authors.forename: Kristin
authors.initials: K
authors.lastname: Anacker
authors.forename: Johannes
authors.initials: J
authors.lastname: Müller
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Lesch
authors.forename: Burkhard
authors.initials: B
authors.lastname: Brocke
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000704:Analysis of Variance; D001386:Azides / Q000378:metabolism; D001767:Blinking / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D016009:Chi-Square Distribution; D005072:Evoked Potentials, Auditory / Q000235:genetics*; D005091:Exons; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D005838:Genotype; D006801:Humans; D008297:Male; D015282:Octreotide / Q000031:analogs & derivatives* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011930:Reaction Time / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4
chemical_list: D001386:Azides; C493599:DRD4 protein, human; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; C074329:EE 581; D015282:Octreotide