Action of ondansetron and CP-99,994 to modify behavior and antagonize cisplatin-induced emesis in the ferret.
The action of ondansetron (1 mg/kg, i.p.) and (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994; 10 mg/kg, i.p.) on spontaneous behavior and the emesis induced by cisplatin (10 mg/kg, i.p.) was studied in the ferret. Ondansetron was inactive to modify behavior, but CP-99,994 reduced spontaneous locomotor activity and lip licking by 48% (P<0.01) and 79% (P<0.01), respectively; CP-99,994 also abolished spontaneous burrowing activity (P<0.05). Treatment of animals with cisplatin induced an emetic response that was abolished by both ondansetron and CP-99,994 (P<0.01). However, cisplatin did not significantly modify other behavioral measures although animals that received CP-99,994, cisplatin, or CP-99,994 in combination with cisplatin exhibited more episodes of defecation than animals that received ondansetron (P<0.05). The action of CP-99,994 to modify behavior in this species is discussed in relation to animal models of nausea.
Lau
Angie H Y
AH
Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
Kan
Kelvin K W
KK
Lai
Helen W
HW
Ngan
Man-P
MP
Rudd
John A
JA
Wai
Man-K
MK
Yew
David T W
DT
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002945:Cisplatin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D005289:Ferrets; D008297:Male; D017294:Ondansetron / Q000494:pharmacology / Q000627:therapeutic use*; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
D000932:Antiemetics; D010880:Piperidines; C080755:3-(2-methoxybenzylamino)-2-phenylpiperidine; D017294:Ondansetron; D002945:Cisplatin