title: [The effect of disc degeneration on the structural property distributions in the cervical vertebral endplates].
abstract: OBJECTIVE
  To study the effect of disc degeneration on the structural property distributions in the cervical vertebral endplates.
  
  
  METHODS
  A 2 mm-diameter hemispherical indenter was used to perform indentation tests at 0.03 mm/s to the depth of 2 mm at 20 normalized locations in 50 bony endplates of intact human cervical vertebrae (C2 approximately C7). The resulting load-displacement curves were used to extract the failure load and stiffness of each test site. Grade of disc degeneration was determined using Nachemson's grading scale. One-way ANOVA, factorial analyses, SNK tests and correlate analyses were used to analyze the result data.
  
  
  RESULTS
  Both the failure load and stiffness decreased with disc degeneration in the cervical endplates (P <0.001, both), and correlated significantly with the disc degeneration (rs=-0.429 and rs=-0.244, respectively). Only the distribution of superior cervical endplate changed with disc degeneration, but that of inferior cervical endplate changed little.
  
  
  CONCLUSIONS
  The structural property distributions in the cervical vertebral endplates change significantly in the degenerated discs. It suggests that disc degeneration is an important factor to evaluate the intervertebral implant subsidence in anterior cervical fusion.
authors.affiliation: Key Laboratory of Medical Biomechanics of People's Liberation Army, Nanfang Medical University, Guangzhou 510515, China.
authors.forename: Jian-yi
authors.initials: JY
authors.lastname: Li
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Zhao
authors.forename: Qing-an
authors.initials: QA
authors.lastname: Zhu
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Lin
authors.forename: Mei-chao
authors.initials: MC
authors.lastname: Zhang
mesh_terms: D001696:Biomechanical Phenomena; D002574:Cervical Vertebrae / Q000503:physiopathology*; D019245:Compressive Strength / Q000502:physiology; D006801:Humans; D007403:Intervertebral Disc / Q000502:physiology; D007405:Intervertebral Disc Displacement / Q000503:physiopathology*; D016474:Weight-Bearing / Q000502:physiology