An asymmetric synthesis of both enantiomers of the indole alkaloid deplancheine.
We report a novel, facile and asymmetric approach to both enantiomers of the indole alkaloid deplancheine from a readily available, nonracemic chiral template. The natural product and its antipode are isolated with >95% ee.
Allin
Steven M
SM
Department of Chemistry, Loughborough University, Loughborough, Leicestershire, LE11 3TU, England. s.m.allin@lboro.ac.uk
Thomas
Christopher I
CI
Doyle
Kevin
K
Elsegood
Mark R J
MR
D031051:Alstonia / Q000737:chemistry*; D002384:Catalysis; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
D026121:Indole Alkaloids; C496494:deplancheine