title: Haemophilus influenzae: a significant pathogen in acute otitis media.
abstract: Haemophilus influenzae is a major pathogen in acute otitis media (AOM) causing disease that is not clinically distinguishable from that caused by Streptococcus pneumoniae. AOM caused by H. influenzae is particularly associated with older age and recurrent disease. Antibiotics differ in their ability to eradicate H. influenzae from the middle ear space. In the United States, widespread pneumococcal vaccination has increased the importance of H. influenzae as a major therapeutic challenge in the treatment of AOM.
authors.affiliation: Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Eugene
authors.initials: E
authors.lastname: Leibovitz
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: Ron
authors.initials: R
authors.lastname: Dagan
mesh_terms: D000208:Acute Disease; D006193:Haemophilus influenzae / Q000187:drug effects / Q000472:pathogenicity*; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D022401:Meningococcal Vaccines / Q000276:immunology; D008826:Microbial Sensitivity Tests; D010033:Otitis Media / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D022242:Pneumococcal Vaccines / Q000276:immunology; D014611:Vaccination
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines