[Research on the expression of c-myc mRNA in ameloblastoma].
OBJECTIVE
To study the expression of c-myc mRNA in ameloblastoma (AB) and odontogenic keratocyst (OKC) and to investigate the genesis, development and biological characteristics of AB and OKC.


METHODS
We detected c-myc mRNA in 54 cases of AB (31 primary ABs, 19 recurrent Abs and 4 malignant ABs), 16 cases of OKC and 7 cases of normal oral mucosa (NOM) by in situ hybridization. Chi2 test was used to analyze the results.


RESULTS
The positive rate of AB, OKC and NOM was 81.5% (44/54), 75.0% (12/16) and 14.3% (1/7), respectively. There was statistical difference among three groups (chi2=15.488, P<0.05). Comparing the expression of primary AB (71.0%) with recurrent (94.7%), malignant AB (100.0%), there was a significant statistical difference (chi2=16.912, P<0.05).


CONCLUSIONS
The expression of c-myc is important to the genesis and development of AB; following the change of primary, recurrent and malignant AB, the expression of c-myc mRNA increased significantly.It is suggested that c-myc mRNA may be an effective marker to evaluate the prognosis of AB.
Li
Zi-juan
ZJ
Department of Pathology, College of Stomatology, China Medical University, Shengyang 110002, China.
Zhong
Ming
M
Wang
Jie
J
Zhang
Bo
B
Hou
Lin
L
D000564:Ameloblastoma / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007573:Jaw Neoplasms / Q000378:metabolism*; D009061:Mouth Mucosa / Q000378:metabolism; D009807:Odontogenic Cysts / Q000378:metabolism; D009808:Odontogenic Tumors / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D004268:DNA-Binding Proteins; C116115:MYCBP protein, human; D012333:RNA, Messenger; D014157:Transcription Factors