title: [Vitrectomy with daunorubicin].
abstract: OBJECTIVE
  The vitreoretinal re-proliferations (PVR) are the most eminent cause of retinal surgery misfortunes. Daunorubicin has been widely discussed as the antimetabolic drug for PVR treatment for recent 20 years. The aim of the study was to evaluate the usefulness of daunorubicin, applied intravitreally during vitrectomy, as an antiproliferative factor stopping the vitreoretinal re-proliferations in eyes with rhegamatogenous retinal detachment complicated with PVR.
  
  
  METHODS
  Vitrectomy, with daunorubicin infusion (1 microg/ml), was performed in 6 eyes with rhegamatogenous retinal detachment and PVR. In 6 other cases of retinal detachment, the gentamycine (20 mg/ml) solution was used as a vitrectomy infusion. During the 12 months follow-up, the risk of PVR relapse was evaluated.
  
  
  RESULTS
  There was no signs of PVR relapse in the eyes treated with daunorubicin during the 12 months follow-up. As in the group of patients that had no daunorubicin infusion the PVR re-proliferation occurred in 2 of 6 operated eyes.
  
  
  CONCLUSIONS
  12 months follow-up showed that Daunorubicine could be a useful adjuvant drug reducing the rate of re-proliferations in the patients with rhegamatogenous retinal detachment.
authors.affiliation: Katedry i Kliniki Chorób Oczu Akademii Medycznej w Gdańsku.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Raczyńska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gebka
authors.forename: Barbara
authors.initials: B
authors.lastname: Iwaszkiewicz-Bilikiewicz
authors.forename: Cezary
authors.initials: C
authors.lastname: Ciechanowski
mesh_terms: D000328:Adult; D003630:Daunorubicin / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000209:etiology / Q000628:therapy*; D012167:Retinal Perforations / Q000150:complications; D055502:Secondary Prevention; D016896:Treatment Outcome; D014821:Vitrectomy / Q000009:adverse effects / Q000379:methods*; D018630:Vitreoretinopathy, Proliferative / Q000209:etiology / Q000517:prevention & control*
chemical_list: D005839:Gentamicins; D003630:Daunorubicin