title: GeneChip expression analysis of the VqsR regulon of Pseudomonas aeruginosa TB.
abstract: Two interlinked quorum sensing circuits, las and rhl, which control pathogenesis of Pseudomonas aeruginosa are further modulated by numerous regulators, including VqsR (virulence and quorum sensing regulator). High-density oligonucleotide microarrays were used to compare the global expression profile of a wild-type and VqsR mutant in ABC minimal medium. The expression of a large group of metabolic genes, ECF sigma factors as well as of many quorum-sensing genes previously not assigned to VqsR-regulon was found to be affected by the disruption of vqsR.
authors.affiliation: Clinical Research Group OE 6711, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. juhas.mario@mh-hannover.de
authors.forename: Mario
authors.initials: M
authors.lastname: Juhas
authors.forename: Lutz
authors.initials: L
authors.lastname: Wiehlmann
authors.forename: Prabhakar
authors.initials: P
authors.lastname: Salunkhe
authors.forename: Jörg
authors.initials: J
authors.lastname: Lauber
authors.forename: Jan
authors.initials: J
authors.lastname: Buer
authors.forename: Burkhard
authors.initials: B
authors.lastname: Tümmler
mesh_terms: D003470:Culture Media; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D020411:Oligonucleotide Array Sequence Analysis; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000502:physiology; D018085:Regulon / Q000235:genetics; D012808:Sigma Factor / Q000502:physiology; D014774:Virulence / Q000235:genetics
chemical_list: D003470:Culture Media; D012808:Sigma Factor