title: Successful pregnancy and delivery after removal of gonadotrope adenoma secreting follicle-stimulating hormone in a 29-year-old amenorrheic woman.
abstract: We report a case of ovarian hyperstimulation related to a gonadotroph adenoma in a 29-year-old woman. The patient presented with amenorrhea and large cystic ovaries. Her serum estradiol was markedly elevated (up to 31,100 pmol/l). Serum LH was low, but serum FSH and PRL were normal. Cranial magnetic resonance imaging study revealed a pituitary macroadenoma. After successful removal of the pituitary tumor, FSH, LH and estradiol normalized and fluctuated within normal ranges thereafter. The patient resumed regular cycles of menstruation and conceived spontaneously. During pregnancy, estradiol increased and FSH and LH decreased. The finding confirms restoration of negative feedback of estradiol on FSH and LH secretion. The pregnancy course was uneventful and enlargement of ovaries did not occur.
authors.affiliation: Department of Obstetrics and Gynecology, Chiba University Hospital, Chiba University School of Medicine, Chiba, Japan. sugitatsu@faculty.chiba-u.jp <sugitatsu@faculty.chiba-u.jp>
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sugita
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Seki
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Nagai
authors.forename: Naokatsu
authors.initials: N
authors.lastname: Saeki
authors.forename: Akira
authors.initials: A
authors.lastname: Yamaura
authors.forename: Sawako
authors.initials: S
authors.lastname: Ohigashi
authors.forename: Arifumi
authors.initials: A
authors.lastname: Iwata
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tatsuno
authors.forename: Souei
authors.initials: S
authors.lastname: Sekiya
mesh_terms: D000236:Adenoma / Q000150:complications / Q000378:metabolism* / Q000601:surgery*; D000328:Adult; D000568:Amenorrhea / Q000209:etiology; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008279:Magnetic Resonance Imaging; D010048:Ovarian Cysts / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism* / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome; D014463:Ultrasonography
chemical_list: D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone