title: Long-term treatment of plastic bronchitis with aerosolized tissue plasminogen activator in a Fontan patient.
abstract: OBJECTIVE
  To report the successful treatment of plastic bronchitis with aerosolized tissue plasminogen activator.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A 4-yr-old boy with congenital heart disease, who developed plastic bronchitis 33 months after a Fontan operation
  
  
  METHODS
  Long-term treatment with aerosolized tissue plasminogen activator.
  
  
  RESULTS
  We describe the case of a boy who developed recurrent episodes of life-threatening airway obstruction secondary to plastic bronchitis. Following the failure of multiple therapeutic interventions, his condition improved significantly with aerosolized tissue plasminogen activator. Several attempts to wean him off this treatment resulted in clinical deterioration. He has remained on long-term aerosolized tissue plasminogen activator.
  
  
  CONCLUSIONS
  Treatment of plastic bronchitis with aerosolized tissue plasminogen activator may benefit patients in whom other therapies have failed.
authors.affiliation: Pediatric Critical Care, Advocate Hope Children's Hospital, Oak Lawn, IL 60453, USA. wakehamdoc@aol.com
authors.forename: Martin K
authors.initials: MK
authors.lastname: Wakeham
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Van Bergen
authors.forename: Luis E
authors.initials: LE
authors.lastname: Torero
authors.forename: Javeed
authors.initials: J
authors.lastname: Akhter
mesh_terms: D000280:Administration, Inhalation; D000402:Airway Obstruction / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D001989:Bronchiolitis Obliterans / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D002675:Child, Preschool; D018729:Fontan Procedure / Q000009:adverse effects*; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D008297:Male; D010960:Plasminogen Activators / Q000008:administration & dosage / Q000627:therapeutic use*; D012008:Recurrence; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator