title: Expression and cDNA sequence of matrix metalloproteinase-2 (MMP-2) in a mammalian model of human disease processes: Tupaia belangeri.
abstract: Matrix metalloproteinase-2 (MMP-2) is one of a family of proteolytic enzymes that are involved in the remodelling of tissue during normal growth processes and is capable of degrading structural components of the extracellular matrix. Increases in MMP-2 expression and activity have been reported in diseases that involve degradation of the extracellular matrix. Reported here for the first time are the relative levels of expression of MMP-2 in tissues of the tree shrew along with 2587 bases of the mRNA sequence. Translation of this sequence predicts a protein 660 amino acids in length, containing all of the features expected of mammalian MMP-2. The tree shrew is a species close to the primate line and is an emerging animal model for a variety of human diseases, including hepatitis and myopia that feature MMP-2 mediated remodelling of the extracellular matrix.
authors.affiliation: Department of Optometry and Vision Sciences, University of Melbourne, Australia.
authors.forename: Megan S
authors.initials: MS
authors.lastname: Kenning
authors.forename: Alex
authors.initials: A
authors.lastname: Gentle
authors.forename: Neville A
authors.initials: NA
authors.lastname: McBrien
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D004195:Disease Models, Animal; D015870:Gene Expression; D020778:Matrix Metalloproteinase 2 / Q000235:genetics*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D013045:Species Specificity; D014417:Tupaia / Q000235:genetics*
chemical_list: D017931:DNA Primers; D012333:RNA, Messenger; D020778:Matrix Metalloproteinase 2