Orlistat for obesity: benefits beyond weight loss.
Orlistat lowers lipids and improves insulin sensitivity, but its effect on other metabolic syndrome related parameters is not known. To assess its influence on adiponectin, high sensitive C-reactive protein (hs-CRP) and other metabolic syndrome related parameters, this study enrolled 106 participants in a weight-reduction program and categorized them into a group of 51 who had been treated with orlistat 360 mg/day for one year and a group of 55 age and sex and body mass index (BMI) matched controls. The orlistat group had greater changes in BMI, % body fat (% BF), waist circumference, and insulin resistance, hs-CRP, leptin and adiponectin levels after one year on the program than the controls. After adjusting for % BF and waist circumference, change of serum leptin and adiponectin levels remained significantly different. It was found that orlistat could effectively manage obesity related co-morbidities, especially insulin resistance and atherosclerosis risk. It decreases leptin and increases adiponectin independent of % BF and waist circumference. Therefore, orlistat appears to have anti-diabetic and anti-atherogenic properties and may help prevent metabolic syndrome in the overweight people.
Hsieh
Ching-Jung
CJ
Division of Edocrinology and Metabolosm, Department of Internal Medicine, Chang Gung Memorial Hospital, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 83305, Taiwan. c2607c@ms56.hinet.net
Wang
Pei-Wen
PW
Liu
Rue-Tsuan
RT
Tung
Shih-Chen
SC
Chien
Wen-Yen
WY
Chen
Jung-Fu
JF
Chen
Chen-Hsiong
CH
Kuo
Ming-Chun
MC
Hu
Ya-Hui
YH
D000328:Adult; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000517:prevention & control; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000517:prevention & control; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007783:Lactones / Q000627:therapeutic use*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D000077403:Orlistat; D015431:Weight Loss / Q000187:drug effects / Q000502:physiology*
D019440:Anti-Obesity Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007783:Lactones; D008074:Lipoproteins; D002097:C-Reactive Protein; D000077403:Orlistat; D002784:Cholesterol