[Optimization of tuberculosis complex chemotherapy with the use of moxifloxacin].
It was shown in vitro that moxifloxacin by its activity against Mycobacterium tuberculosis (susceptible and resistant to the main antituberculosis agents) was highly superior to lomefloxacin (by 2 to 4 times by the MIC and by 4 times by the MBC). In murine lung tissue culture the highest effect was observed with the use of moxifloxacin in combination with isoniazid and pirazinamide. The efficacy of the regimens with the use of moxifloxacin was estimated in the treatment of 152 patients with pulmonary tuberculosis diagnosticated for the first time. The use of moxifloxacin was shown to be most advantageous in complex therapy of patients with extended and progressive tuberculosis due to polyresistant Mycobacterium tuberculosis strains or patients with concomitant nonspecific inflammatory diseases of the respiratory tracts due to a great variety of grampositive and gramnegative organisms, acid fact bacteria, atypical bacteria and a great variety of anaerobes. The tolerance of the treatment regimens with the use of moxifloxacin was mainly satisfactory.
Perel'man
M I
MI
Cokolova
G B
GB
Mozhokina
G N
GN
Lazareva
Ia V
IaV
Strekchev
A Iu
AIu
Elistratova
N A
NA
D000293:Adolescent; D000328:Adult; D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage*; D001372:Aza Compounds / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008875:Middle Aged; D000077266:Moxifloxacin; D011718:Pyrazinamide / Q000008:administration & dosage*; D011804:Quinolines / Q000008:administration & dosage*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D000995:Antitubercular Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D011718:Pyrazinamide; D000077266:Moxifloxacin; D007538:Isoniazid