[Allogeneic bone marrow transplantation for a patient with malignant histiocytosis].
OBJECTIVE
To observe the efficacy and side effects of allogeneic bone marrow transplantation (allo-BMT) in the treatment of malignant histiocytosis (MH).


METHODS
After conditioning with chemotherapy and total body irradiation, HLA-A, B, DR, DQ compatible allo-BMT was performed in a patient with MH.


RESULTS
DNA fingerprinting showed engraftment on day 22, bone marrow aspiration showed hypercellularity on day 50, and no abnormal cell was found. The patient developed acute graft-versus-host disease ( II degrees) on day 40 and herpes zoster 6 months post-transplantation, and the patient has survived disease-freely for 24 months after allo-BMT.


CONCLUSIONS
This is the first report of treatment of MH with allo-BMT in China, showing that allo-BMT may significantly prolong the survival of MH.
Zhai
M
M
Hu
L
L
Chen
H
H
D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D005500:Follow-Up Studies; D054747:Histiocytic Sarcoma / Q000097:blood / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D016019:Survival Analysis; D014184:Transplantation, Homologous