title: Metrazol thresholds in inbred and non-inbred audiosensitive mice.
abstract: Mice of the O'Grady strain which were inbred for susceptibility to audiogenic seizures were found to be more sensitive to pentamethylenetetrazol (Metrazol) convulsions than mice of the parent Swiss-Webster strain from which they were originally derived. A dose of 35 mg/kg Metrazol was required to produce a 50% convulsive response (CD50) in O'Grady mice and 50 mg/kg in the control parent strain. No differences in convulsive thresholds to Metrazol were obtained, however, between untreated Swiss-Webster mice and mice of the same strain made audiosuseptible by rubidium chloride intake or magnesium deficiency.
authors.affiliation: New York State Psychiatric Institute, New York, NY 10032, USA.
authors.forename: G J
authors.initials: GJ
authors.lastname: Alexander
authors.forename: L M
authors.initials: LM
authors.lastname: Kopeloff
authors.forename: R B
authors.initials: RB
authors.lastname: Alexander
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D003292:Convulsants / Q000494:pharmacology*; D020195:Epilepsy, Reflex / Q000139:chemically induced* / Q000503:physiopathology; D008275:Magnesium Deficiency / Q000503:physiopathology; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000494:pharmacology*; D012413:Rubidium / Q000494:pharmacology
chemical_list: D003292:Convulsants; D012413:Rubidium; D010433:Pentylenetetrazole