Micronuclei level in exfoliated buccal mucosa cells of patients with benign and malignant tumors of female reproductive organs and breast.
Micronucleus (MN) levels in exfoliated buccal mucosa cells of primary breast, cervix and corpus uteri cancer patients, and patients with benign tumors of uterus (myoma) and breast (fibroadenoma) were studied. Significantly increased number of MN in cells of cancer patients was observed compared to both healthy persons and patients with benign tumors. In patients with benign tumors no increase in MN quantity was observed. The evaluation of MN number in buccal mucosa cells shows genomic instability caused by malignant tumor in somatic cells of humans.
Nersesyan
A K
AK
Cancer Research Centre, Yerevan, Armenia. armenn@freenet.am
Adamyan
R T
RT
D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D018226:Fibroadenoma / Q000473:pathology*; D006801:Humans; D007889:Leiomyoma / Q000473:pathology*; D048629:Micronuclei, Chromosome-Defective / Q000706:statistics & numerical data; D015162:Micronucleus Tests; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D002583:Uterine Cervical Neoplasms / Q000473:pathology; D014594:Uterine Neoplasms / Q000473:pathology*