title: Intravascular ultrasound assessment of neointima distribution and the length of stent that was free of intravascular ultrasound-detectable intimal hyperplasia in paclitaxel-eluting stents.
abstract: Using data from the ASian Paclitaxel-Eluting Stent Clinical Trial, a 3-center, randomized, placebo-controlled trial of nonpolymeric paclitaxel-coated stents with a single center, 81-patient intravascular ultrasound (IVUS) substudy, the length of a stent that was free of IVUS-detectable intimal hyperplasia measured 3.2 +/- 4.8 mm in placebo stents, 6.1 +/- 5.6 mm in low-dose stents, and 8.7 +/- 6.1 mm in high-dose stents (p = 0.0029). IVUS percent neointima volume obstruction correlated with the length of this IVUS neointima-free segment (r = 0.785, p <0.0001); angiographic late lumen loss and follow-up diameter stenosis also correlated with the IVUS neointima-free length of the stents (r = 0.670, p <0.0001 and r = 0.679, p <0.0001, respectively.
authors.affiliation: Department of Medicine, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.forename: Myeong-Ki
authors.initials: MK
authors.lastname: Hong
authors.forename: Albert E
authors.initials: AE
authors.lastname: Raizner
authors.forename: Cheol Whan
authors.initials: CW
authors.lastname: Lee
authors.forename: Jae-Joong
authors.initials: JJ
authors.lastname: Kim
authors.forename: Esteban
authors.initials: E
authors.lastname: Escolar
authors.forename: Neal E
authors.initials: NE
authors.lastname: Fearnot
authors.forename: Seong-Wook
authors.initials: SW
authors.lastname: Park
authors.forename: Seung-Jung
authors.initials: SJ
authors.lastname: Park
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Weissman
mesh_terms: D023903:Coronary Restenosis / Q000000981:diagnostic imaging* / Q000517:prevention & control*; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology*; D016503:Drug Delivery Systems; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging; D017239:Paclitaxel / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D015607:Stents; D017539:Tunica Intima / Q000000981:diagnostic imaging* / Q000473:pathology*; D018084:Ultrasonography, Interventional
chemical_list: D017239:Paclitaxel