title: Autoantibody synthesis in primary progressive multiple sclerosis patients treated with interferon beta-1b.
abstract: We conducted an open-labeled clinical trial of interferon beta-1b (IFNB) treatment in 20 patients with primary progressive multiple sclerosis (PPMS) and longitudinally monitored autoantibodies against double-stranded DNA (dsDNA), thyroid peroxidase (TPO),myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), synapsin and S-100B. Before treatment, one patient had elevated TPO antibodies, four patients had elevated antibodies against S-100B, two patients against MOG or synapsin and one patient against MBP. In two patients we observed a continuous increase of dsDNA or TPO antibodies above the normal range. This rise paralleled IFNB treatment. In addition, 11 of 20 patients developed neutralizing antibodies against IFNB. There was no increase of autoantibodies directed against central nervous system antigens. Like patients with relapsing remitting or secondary progressive multiple sclerosis, PPMS patients may be at risk of an autoimmune response during IFNB treatment.
authors.affiliation: Neurologische Klinik, Ruppiner Kliniken GmbH, Fehrbelliner Strabe 38, 16816, Neuruppin, Germany. a.bitsch@ruppiner-kliniken.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Bitsch
authors.forename: Alexander
authors.initials: A
authors.lastname: Dressel
authors.forename: Kathrin
authors.initials: K
authors.lastname: Meier
authors.forename: Timon
authors.initials: T
authors.lastname: Bogumil
authors.forename: Florian
authors.initials: F
authors.lastname: Deisenhammer
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Tumani
authors.forename: Bernd
authors.initials: B
authors.lastname: Kitze
authors.forename: Sigrid
authors.initials: S
authors.lastname: Poser
authors.forename: Frank
authors.initials: F
authors.lastname: Weber
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000276:immunology* / Q000627:therapeutic use*; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000188:drug therapy* / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D011994:Recombinant Proteins; D000068576:Interferon beta-1b; D016899:Interferon-beta; D004247:DNA; D007453:Iodide Peroxidase