title: [Progress on polydactyly character of vertebrate].
abstract: Polydactyly is a common abnormal limb phenotype in vertebrate and there is similar limb phenotype among different species. Research shows that polydactyly has a similar development mechanism, and this kind of polydactyly character seems to be controlled by homologous genes among species. The latest research results on human and mouse further shows that PPD should be caused by the disruption of a long range cis-acting regulator for Shh within Lmbr1 intron. Here the development mechanism and related genes controlling polydactyly character of vertebrate are reviewed.
authors.affiliation: State Key National Laboratory of Biotechnology, China Agricultural University, Beijing 100 094, China. hyanqun@yahoo.com.cn
authors.forename: Yan-Qun
authors.initials: YQ
authors.lastname: Huang
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Deng
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Xiang-Pin
authors.initials: XP
authors.lastname: Qiu
mesh_terms: D000818:Animals; D002889:Chromosomes, Human, Pair 2; D002897:Chromosomes, Human, Pair 7; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D007438:Introns; D051741:Kruppel-Like Transcription Factors / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics; D010641:Phenotype; D017689:Polydactyly / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics; D000074290:Zinc Finger Protein Gli3
chemical_list: C065683:GLI3 protein, human; C513184:HOXD13 protein, human; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins; D051741:Kruppel-Like Transcription Factors; C485955:LMBR1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C509239:SHH protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D000074290:Zinc Finger Protein Gli3