Positive and negative ion chemistry of the anesthetic halothane (1-bromo-1-chloro-2,2,2-trifluoroethane) in air plasma at atmospheric pressure.
The ion chemistry of 1-bromo-1-chloro-2,2,2-trifluoroethane (the common anesthetic halothane) in air plasma at atmospheric pressure was investigated by atmospheric pressure chemical ionization mass spectrometry (APCI-MS). The major positive ion observed at low declustering (API interface) energies is the ionized dimer, M(+.)M, an unexpectedly abundant species which possibly is stabilized by two H-bonding interactions. At higher energies [M--HF](+.) and [M--Br](+) prevail; the former, corresponding to ionized olefin [ClBrC=CF(2)](+.), appears to originate from M(+.)M and is quite stable towards fragmentation. The latter fragment ion ([M--Br](+)) and its analogue, [M--Cl](+), which is also observed though at much lower abundance, are originally ethyl cations (+)CHX--CF(3) (X = Br, Cl) which, upon collisional activation, rearrange and fragment to CHFX(+) via elimination of CF(2). All of the above described ions are also observed in humid air: in addition, the oxygenated ion [ClBrC=CFOH](+.) also forms in humid air via water addition to [ClBrC=CF(2)](+.) and HF elimination, as observed earlier for ionized trichloroethene. In contrast with similar chloro- and fluoro-substituted ethanes, halothane does not react with H(3)O(+) in the APCI plasma, a result confirmed by selected ion APCI triple-quadrupole (TQ) experiments. Major negative ions formed from halothane in the air plasma are Br(-) and, to a lesser extent, Cl(-), and their complexes with neutral halothane. APCI-TQ experiments indicated that Br(-) and Cl(-) are formed via reaction of halothane with O(2) (-.), O(2) (-.)(H(2)O) and O(3) (-.), possibly via dissociative electron transfer or nucleophilic substitution. Competing proton transfer was also observed in the reaction with O(2) (-.) and, at high halothane pressure, also with O(2) (-.)(H(2)O); at lower pressures the molecular anion M(-.) was observed instead. The other minor anions of the air plasma, NO(2) (-), N(2)O(2) (-.) and NO(3) (-), were found to be unreactive towards halothane.
Marotta
Ester
E
INTM del CNR-Sezione di Padova, Dipartimento di Scienze Chimiche, Università di Padova, Via Marzolo 1, 35131 Padova, Italy.
Bosa
Elisabetta
E
Scorrano
Gianfranco
G
Paradisi
Cristina
C
D000388:Air / Q000032:analysis*; D000395:Air Pollutants, Occupational / Q000032:analysis*; D018685:Anesthetics, Inhalation / Q000737:chemistry*; D000838:Anions / Q000737:chemistry; D001274:Atmospheric Pressure; D006221:Halothane / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D000395:Air Pollutants, Occupational; D018685:Anesthetics, Inhalation; D000838:Anions; D006221:Halothane