title: Design and in vitro evaluation of new drug-in-adhesive formulations of fentanyl transdermal patches.
abstract: The present research was designed to evaluate different matrix, drug-in-adhesive and reservoir formulations of fentanyl transdermal patches. The target was to design drug-in-adhesive patches (DIAPs); a full factorial design was used. Different types and amounts of liquid, pressure-sensitive adhesives (PSAs) were used and evaluated with respect to drug release and adhesive properties. A very simple but precise method, the simplified peel 180 degrees test, was developed to measure and compare adhesive properties of transdermal patches. The results showed that release kinetics obeyed the square root of time or Higuchi model, indicating the diffusion controlled release mechanism. It was found that the amount of fentanyl needed for each 10 cm(2) three-days DIAP should be 3.3 mg. The respective amounts for reservoir and matrix patches were 2.5 and 5 mg. It was concluded that acrylic PSAs showed the best adhesion and release properties.
authors.affiliation: Tehran University of Medical Sciences, Faculty of Pharmacy, Tehran, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Mehdizadeh
authors.forename: Tayebe
authors.initials: T
authors.lastname: Toliate
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Rouini
authors.forename: Sharyar
authors.initials: S
authors.lastname: Abashzadeh
authors.forename: Farid
authors.initials: F
authors.lastname: Dorkoosh
mesh_terms: D000268:Adhesiveness; D000269:Adhesives / Q000737:chemistry*; D000279:Administration, Cutaneous; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D004058:Diffusion; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D005283:Fentanyl / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D008422:Materials Testing; D018709:Statistics, Nonparametric
chemical_list: D000269:Adhesives; D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D005283:Fentanyl