title: Paraneoplastic acute diffuse encephalitis revealing Hodgkin's disease.
abstract: Paraneoplastic neurological syndromes are associated with various cancers. Cerebellar and limbic paraneoplastic manifestations are known to be associated with Hodgkin's disease (HD), but reports of diffuse encephalitis associated with HD are very rare. We report a case of acute severe diffuse encephalitis revealing a HD. Clinical presentation, cerebro-spinal fluid modifications and magnetic resonance imagery data are described. The treatment associated specific chemotherapy and plasma exchange. The neurological status improved dramatically within the first days of treatment, with parallel neoplasm regression. This case stresses the fact that encephalopathy can be the first sign of an undiagnosed extra-cerebral neoplasm.
authors.affiliation: Service des Maladies Infectieuses et Tropicales DMAS, Centre Hospitalo-Universitaire de Grenoble BP 217, 38043, Grenoble Cedex 09 France. OEpaulard@chu-grenoble.fr
authors.forename: O
authors.initials: O
authors.lastname: Epaulard
authors.forename: S
authors.initials: S
authors.lastname: Courby
authors.forename: P
authors.initials: P
authors.lastname: Pavese
authors.forename: S
authors.initials: S
authors.lastname: Grand
authors.forename: M
authors.initials: M
authors.lastname: Laramas
authors.forename: L
authors.initials: L
authors.lastname: Molina
authors.forename: J P
authors.initials: JP
authors.lastname: Brion
authors.forename: P-E
authors.initials: PE
authors.lastname: Colle
authors.forename: J J
authors.initials: JJ
authors.lastname: Sotto
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D004660:Encephalitis / Q000150:complications* / Q000473:pathology*; D006689:Hodgkin Disease / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000473:pathology*