title: Investigation of cardiac and cardio-therapeutical phenomena using a pulsatile circulatory model.
abstract: For many years computer models of the cardiovascular system have existed with which the complex physiological interrelations of regulation processes may be studied. However, one major disadvantage of these models is the simplified modeling of the heart kinematics whereby the short term regulation effects of the heart itself on varying physical strains may only be simulated rudimentarily. The developed pulsatile model emphasizes the detailed description of the systolic wall tension progression subject to the Hill/Frank-Starling mechanisms and the simulation of the cardiac valves. Moreover, to be able to describe long term effects the pulsatile model was coupled to the established cardio vascular model of Guyton. Using the coupled system the influences of impaired valve function and ventricular relaxation disorders on the cardiac output as well as the need for an implementation of a physical strain dependent av-delay in existing pacemaker types were investigated. Both the dynamics and the steady-state values of a subset of variables (pressure, volume, flow) were successfully validated by comparing them to published experimental and clinical recordings.
authors.affiliation: Department of Biomedical Engineering, Medical Faculty, University Center of Medical Engineering (UZMT), Ruhr-University Bochum, Germany. welp@biomed.ruhr-uni-bochum.de
authors.forename: C
authors.initials: C
authors.lastname: Welp
authors.forename: J
authors.initials: J
authors.lastname: Werner
authors.forename: D
authors.initials: D
authors.lastname: Böhringer
authors.forename: M
authors.initials: M
authors.lastname: Hexamer
mesh_terms: D001696:Biomechanical Phenomena; D002302:Cardiac Output / Q000502:physiology; D003198:Computer Simulation; D003199:Computer Systems; D006333:Heart Failure / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006351:Heart Valves / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007260:Infusion Pumps; D009200:Myocardial Contraction / Q000502:physiology; D011673:Pulsatile Flow / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D013223:Statistics as Topic; D016277:Ventricular Function, Left / Q000502:physiology