title: Fulminant varicella infection complicated with acute respiratory distress syndrome, and disseminated intravascular coagulation in an immunocompetent young adult.
abstract: Primary varicella infection in immunocompetent adults is very rare, but it has a high mortality rate because of serious complications. We describe a case of varicella infection in a previously healthy young adult complicated with acute respiratory distress syndrome (ARDS), rhabdomyolysis, acute hepatitis and disseminated intravascular coagulation (DIC). Acyclovir was administered for varicella infection and the ARDS was successfully treated with steroidpulse therapy, hemofiltration and a mechanical respiratory support with a positive end-expiratory pressure. Early administration of antiviral agents and extensive management were thought to be necessary for such patients with severe complications.
authors.affiliation: Second Department of Internal Medicine, School of Medicine, Fukui University, Fukui.
authors.forename: Soshoku
authors.initials: S
authors.lastname: Lee
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ito
authors.forename: Tomoko
authors.initials: T
authors.lastname: Inagaki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Okajima
authors.forename: Atsushi
authors.initials: A
authors.lastname: Muramatsu
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ito
authors.forename: Manabu
authors.initials: M
authors.lastname: Dojo
authors.forename: Yukinao
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Azuma
authors.forename: Masaru
authors.initials: M
authors.lastname: Kuriyama
mesh_terms: D000328:Adult; D002644:Chickenpox / Q000150:complications* / Q000175:diagnosis; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D006801:Humans; D007121:Immunocompetence; D008297:Male; D011024:Pneumonia, Viral / Q000150:complications* / Q000175:diagnosis; D012128:Respiratory Distress Syndrome / Q000150:complications*