Indocarbazostatins C and D, new inhibitors of NGF-induced neuronal differentiation in PC12 cells.
Indocarbazostatins C (3) and D (4), new inhibitors of NGF-induced neurite outgrowth were isolated from culture broth of a mutant strain, Streptomyces sp. MUV-6-83. The structural elucidation of 3 and 4 revealed that these inhibitors were methyl ester analogs of the corresponding ethyl ester compounds, indocarbazostatin (1) and indocarbazostatin B (2), respectively.
Feng
Yufei
Y
Graduate School of Agriculture, Hokkaido University, North-9, West-9, Kita-ku, Sapporo 060-8589, Japan.
Matsuura
Nobuyasu
N
Ubukata
Makoto
M
D000818:Animals; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D005998:Glycine / Q000031:analogs & derivatives*; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020932:Nerve Growth Factor / Q000037:antagonists & inhibitors*; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D051381:Rats; D013302:Streptomyces / Q000378:metabolism*; D013329:Structure-Activity Relationship
D002227:Carbazoles; D007211:Indoles; C402701:indocarbazostatin; C458887:indocarbazostatin B; C495798:indocarbazostatin C; C495799:indocarbazostatin D; C084257:PC 12 ester; D020932:Nerve Growth Factor; D005998:Glycine