title: [Development of new synthetic method using organometallic complexes and an application toward natural product synthesis].
abstract: Recently, many organometallic complexes, such as palladium, nickel, ruthenium, titanium complexes and others, were used for synthetic organic chemistry. We have developed many novel synthetic methods using these organometallic complexes for synthetic organic chemistry. As the organometallic complexes, nickel, chromium, molybdenum, ruthenium, zirconium, titanium, and palladium complexes, were used. Furthermore, bimetallic complexes having silicon-tin and silicon-zirconium bonds were investigated. On the other hand, utilization of gases in synthetic organic chemistry has been also developed. 1 atm pressure of gases such as CO, CO(2), N(2), ethylene and acetylene, could be used and the reaction procedure is very simple, that a balloon filled with a gas is connected on the top of the flask. Using our novel synthetic methods, we have synthesized many natural products and biologically active substances, such as cephalotaxin, mesembrine, tubifoline, strychnine, stemoamide, lycopodine, pumiliotoxin C, beta-lactam, carbapenam and benzodiazepinone derivatives.
authors.affiliation: Department of Fine Synthetic Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. mori@hokudai.ac.jp
authors.forename: Miwako
authors.initials: M
authors.lastname: Mori
mesh_terms: D000114:Acetylene; D000470:Alkaloids / Q000138:chemical synthesis; D001570:Benzodiazepinones / Q000138:chemical synthesis; D015780:Carbapenems / Q000138:chemical synthesis; D002245:Carbon Dioxide; D002248:Carbon Monoxide; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D003500:Cyclization; D005030:Ethylenes; D005740:Gases; D006248:Harringtonines / Q000138:chemical synthesis*; D000077863:Homoharringtonine; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis*; D009584:Nitrogen; D009942:Organometallic Compounds / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis; D011807:Quinolizines / Q000138:chemical synthesis; D013331:Strychnine / Q000138:chemical synthesis; D047090:beta-Lactams / Q000138:chemical synthesis
chemical_list: D000470:Alkaloids; D001570:Benzodiazepinones; D015780:Carbapenems; D005030:Ethylenes; D005740:Gases; D006248:Harringtonines; D026121:Indole Alkaloids; D007211:Indoles; D009942:Organometallic Compounds; D011804:Quinolines; D011807:Quinolizines; D047090:beta-Lactams; C431471:tubifoline; D002245:Carbon Dioxide; C011093:pumiliotoxin C; C016542:lycopodine; D000077863:Homoharringtonine; D002248:Carbon Monoxide; C011300:mesembrine; C036216:ethylene; D013331:Strychnine; D009584:Nitrogen; D000114:Acetylene