[Detection and analysis of the sub-types of -alpha3.7 in Chinese].
-alpha3.7 is a common deletional alpha-thalassemia-2 in China. According to different recombination sites,-alpha3.7 can be divided into -alpha3.7I,-alpha3.7IIand -alpha3.7III. The frequency and population distribution of these -alpha3.7 are quite different. In this study,we detected 56 patients among Chinese population of -alpha3.7 defect in alpha globin gene by PCR method, then the PCR product was digested by the restriction enzyme ApalI and BalI. The sub-typing result shows that in the 56 cases of -alpha3.7 defect,54 out of 56 is -alpha3.7I,2 out of 56 is -alpha3.7II and none of -alpha3.7III is detected. This result enriches the data about the alpha thalassemia genotypes of Chinese people.
Chen
Su-Qin
SQ
Department of Medical Genetics, Zhongshan Medical College, SunYat-sen University, Guangzhou 510089, China. chensuqin99@hotmail.com
Li
Hong-Yi
HY
Chen
Zheng
Z
Duan
Shan
S
Chen
Lu-Ming
LM
Tian
Qiu-Hong
QH
Du
Chuan-Shu
CS