title: Adaptation of the ICRP publication 66 respiratory tract model to data on plutonium biokinetics for Mayak workers.
abstract: The biokinetics of inhaled plutonium were analyzed using compartment models representing their behavior within the respiratory tract, the gastrointestinal tract, and in systemic tissues. The processes of aerosol deposition, particle transport, absorption, and formation of a fixed deposit in the respiratory tract were formulated in the framework of the Human Respiratory Tract Model described in ICRP Publication 66. The values of parameters governing absorption and formation of the fixed deposit were established by fitting the model to the observations in 530 autopsy cases. The influence of smoking on mechanical clearance of deposited plutonium activity was considered. The dependence of absorption on the aerosol transportability, as estimated by in vitro methods (dialysis), was demonstrated. The results of this study were compared to those obtained from an earlier model of plutonium behavior in the respiratory tract, which was based on the same set of autopsy data. That model did not address the early phases of respiratory clearance and hence underestimated the committed lung dose by about 25% for plutonium oxides. Little difference in lung dose was found for nitrate forms.
authors.affiliation: Southern Ural Biophysics Institute, Ozyorskoe Shosse 19, Ozyorsk, Chelyabinsk Region, Russia, 456780, USA. kfe@ornl.gov
authors.forename: V F
authors.initials: VF
authors.lastname: Khokhryakov
authors.forename: K G
authors.initials: KG
authors.lastname: Suslova
authors.forename: V V
authors.initials: VV
authors.lastname: Vostrotin
authors.forename: S A
authors.initials: SA
authors.lastname: Romanov
authors.forename: K F
authors.initials: KF
authors.lastname: Eckerman
authors.forename: M P
authors.initials: MP
authors.lastname: Krahenbuhl
authors.forename: S C
authors.initials: SC
authors.lastname: Miller
mesh_terms: D000042:Absorption; D000336:Aerosols; D000396:Air Pollutants, Radioactive / Q000493:pharmacokinetics / Q000633:toxicity*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D011005:Plutonium / Q000493:pharmacokinetics / Q000633:toxicity*; D011829:Radiation Dosage; D011835:Radiation Protection; D012137:Respiratory System / Q000378:metabolism / Q000528:radiation effects*; D012907:Smoking / Q000009:adverse effects*
chemical_list: D000336:Aerosols; D000396:Air Pollutants, Radioactive; D011005:Plutonium