Optimizing transport of metabolites through large channels: molecular sieves with and without binding.
Using a diffusion model of molecules moving through a pore, we rationalize why biological channels have an affinity for the molecules they have evolved to translocate.
Berezhkovskii
Alexander M
AM
Mathematical and Statistical Computing Laboratory, Division of Bioscience, Center for Information Technology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Bezrukov
Sergey M
SM
D001692:Biological Transport / Q000502:physiology; D001704:Biopolymers / Q000737:chemistry* / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry* / Q000502:physiology; D002463:Cell Membrane Permeability; D003198:Computer Simulation; D004058:Diffusion; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000737:chemistry* / Q000502:physiology; D008954:Models, Biological; D008956:Models, Chemical; D016062:Porosity
D001704:Biopolymers; D007473:Ion Channels