The contribution of genetic and environmental factors to quantitative variability of erythrocyte membrane proteins in primary hypotension.
Our previous studies have shown that, compared with healthy individuals, patients with primary arterial hypotension (PAH) have significant quantitative changes in erythrocyte membrane proteins. The purpose of the present study was to evaluate the contribution made by genetic and environmental factors to quantitative variation of erythrocyte membrane proteins in PAH. We studied 109 hypotensive patients, 124 normotensive subjects, 222 of their first-degree relatives and 24 twin pairs by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis. The decomposition of total phenotypic variance of erythrocyte membrane proteins to genetic and environmental components was performed on the basis of correlations among first-degree relatives by the least squares method. The genetic dominance and shared environmental factors were found to influence the variability of cytoskeletal membrane proteins whose contents were changed in PAH. Furthermore, variations in alpha-spectrin, actin and anion exchanger in hypotensives were substantially influenced by major gene and maternal effects. Ankyrin 2.1 and actin content was under the control of common underlying genes. Variations in membrane-associated glutathione-S-transferase and tropomyosin were predominantly affected by polygenes. These findings suggest that the putative major genes with pleiotropic effects appear to be involved in the control of quantitative disorders of erythrocyte membrane proteins in primary hypotension.
Ivanov
V P
VP
Medical Biology, Genetics and Ecology Department, Kursk State Medical University, Russian Federation, 305041 Kursk, Karl Marx street, 3, Russia.
Polonikov
A V
AV
Solodilova
M A
MA
D000199:Actins / Q000378:metabolism; D001457:Anion Exchange Protein 1, Erythrocyte / Q000378:metabolism; D017487:Ankyrins / Q000378:metabolism; D016022:Case-Control Studies; D004781:Environmental Exposure; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D007022:Hypotension / Q000235:genetics* / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D015800:Protozoan Proteins / Q000378:metabolism; D013049:Spectrin / Q000378:metabolism; D014335:Tropomyosin / Q000378:metabolism; D014427:Twins
D000199:Actins; D001457:Anion Exchange Protein 1, Erythrocyte; D017487:Ankyrins; C411566:EMP3 protein, Plasmodium falciparum; D008565:Membrane Proteins; D015800:Protozoan Proteins; D014335:Tropomyosin; D013049:Spectrin; D005982:Glutathione Transferase