title: Structure of tyroscherin, an antitumor antibiotic against IGF-1-dependent cells from Pseudallescheria sp.
abstract: An antitumor antibiotic, tyroscherin, was isolated from the culture of a fungus identified as Pseudallescheria sp. The structure of tyroscherin including the absolute stereochemistry was determined as shown in Fig. 1 by NMR and degradation studies. Tyroscherin selectively inhibited IGF-1-dependent growth of MCF-7 human breast cancer cells with an IC50 of 9.7 ng/ml.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2461, Yamazaki, Noda-shi, Chiba 278-8510, Japan. hykw@rs.noda.tus.ac.jp
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: Tomoki
authors.initials: T
authors.lastname: Yamashita
authors.forename: Toshiya
authors.initials: T
authors.lastname: Mori
authors.forename: Koji
authors.initials: K
authors.lastname: Nagai
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-Ya
authors.forename: Hidenori
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004837:Epinephrine / Q000031:analogs & derivatives* / Q000737:chemistry*; D005233:Fatty Alcohols / Q000737:chemistry*; D005285:Fermentation; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D011541:Pseudallescheria / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; D005233:Fatty Alcohols; C495800:tyroscherin; D007334:Insulin-Like Growth Factor I; D004837:Epinephrine