Desmoglein genes are up-regulated in the pk mutant mouse.
Plucked (pk) is an autosomal recessive mouse mutation with a hair phenotype that arose spontaneously in the DBA/2J strain. Histological studies indicate that adult pk mutant mice lose truncal hair because of the scarring of follicles due to an apparent obstruction of the outward movement of the hair shaft within the follicular canal. We mapped the pk mutant phenotype to a 1.1cM region of chromosome 18 (between 6.6 and 7.7 cM from the centromere) using 370 backcross progeny. Within this region, among others, are genes for desmosome cadherins. Desmosome cadherins are interesting candidates because of their critical roles for cell-cell adhesion in epidermal function. Northern Blot analysis of wild-type and pk mutant mice indicates that expression of both desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3) is up-regulated in the skin of mutant pk mice.
Luo
Jingqing
J
The Skin Research Center of Johnson & Johnson CPWW, Skillman, NJ 08558, USA. jluol@prdus.jnj.com
Zhang
Lin
L
Stenn
Kurt
K
Prouty
Stephen
S
Parimoo
Satish
S
D000818:Animals; D015820:Cadherins / Q000235:genetics*; D002874:Chromosome Mapping; D003598:Cytoskeletal Proteins / Q000235:genetics*; D051183:Desmoglein 1; D051184:Desmoglein 3; D051182:Desmogleins; D051180:Desmoplakins; D005260:Female; D018859:Hair Follicle / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D009024:Morphogenesis; D009154:Mutation / Q000235:genetics*; D010641:Phenotype; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D015854:Up-Regulation / Q000235:genetics*
D015820:Cadherins; D003598:Cytoskeletal Proteins; C495297:DSG1 protein, human; D051183:Desmoglein 1; D051184:Desmoglein 3; D051182:Desmogleins; D051180:Desmoplakins; C495299:Dsg1a protein, mouse; C495300:Dsg3 protein, mouse; D012333:RNA, Messenger