Bioinformatics-based identification of chemosensory proteins in African Malaria Mosquito, Anopheles gambiae.
Chemosensory proteins (CSPs) are identifiable by four spatially conserved Cysteine residues in their primary structure or by two disulfide bridges in their tertiary structure according to the previously identified olfactory specific-D related proteins. A genomics- and bioinformatics-based approach is taken in the present study to identify the putative CSPs in the malaria-carrying mosquito, Anopheles gambiae. The results show that five out of the nine annotated candidates are the most possible Anopheles CSPs of A. gambiae. This study lays the foundation for further functional identification of Anopheles CSPs, though all of these candidates need additional experimental verification.
Li
Zhengxi
Z
Department of Entomology, China Agricultural University, Beijing 100094, China. zxli@cau.edu.cn
Shen
Zuorui
Z
Zhou
Jingjiang
J
Field
Lin
L
D000595:Amino Acid Sequence; D000818:Animals; D000852:Anopheles / Q000235:genetics*; D002628:Chemoreceptor Cells / Q000737:chemistry / Q000378:metabolism*; D002874:Chromosome Mapping; D019295:Computational Biology; D017124:Conserved Sequence; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D019476:Insect Proteins