title: [Radiosurgery with the Leksell gamma knife in the treatment of solitary brain metastasis--5-year results].
abstract: During five years (1992-1997) 215 patients with solitary brain metastases were treated in the Department of Stereotactic and Radiation Neurosurgery (117 men and 98 women). The most frequent first neurological symptoms were: headache, hemiparesis, seizure, mental and behavioural disturbances. Location of lesion was supratentorial in 163 patients (75.8%) and infratentorial in 52 cases (24.2%). Treatment results: complete and partial regression in 175 patients (81.4%), stabilisation in 30 of patients (14.0%), local progression in 10 patients (4.6%). Local recurrence after initially effective treatment was observed in 11 pts (5.1%). The severity of neurological symptoms was measured by RTOG 4 grades scoring system. The acute and late toxicity was evaluated by SOMA scale (RTOG--Radiation Therapy Oncology Group): grading 0-5. We observed acute toxicity (score 3 and 4) in 20 patients (9.3%) and late (score 3 and 4) in 9 patients (4.2%). Minimal follow up for all patients was 10 months. Median survival for 159 dead patients was 7 months (ranged from 2 to 35 months), median survival for surviving 56 pts was 15.5 months (ranged from 10 to 56 months). One-year survival was 39.5% of all patients.
authors.affiliation: Oddĕlení stereotaktické a radiacní neurochirurgie, Nemocnice Na Homolce, Praha.
authors.forename: G
authors.initials: G
authors.lastname: Simonová
authors.forename: R
authors.initials: R
authors.lastname: Liscák
authors.forename: J
authors.initials: J
authors.lastname: Novotný
authors.forename: J
authors.initials: J
authors.lastname: Novotný
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D016634:Radiosurgery; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome