Sesquiterpenes, lignans and other constituents from Saussurea macrota.
From the methanol extract of the whole plant of Saussurea macrota Franch, 21 compounds were isolated. Their structures were elucidated by spectroscopic methods and X-ray crystallography. Two of them are new: 3alpha-hydroxy-11alphaH-guaia-4(15),10(14)-diene-12,6alpha-olide (1) and 7'-hydroxyiso-lappaol A (11). Compound 2 is reported as a natural compound for the first time. In addition, the compounds 12 and 13 showed significant antitumor activity against Bel-7402 and HO-8910 cells. Some of the compounds exhibited weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli.
Yang
Min
M
College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
Wang
Chun-Ming
CM
Zhang
Qi
Q
Han
Yi-Feng
YF
Jia
Zhong-Jian
ZJ
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000032:analysis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011487:Protein Conformation; D030441:Saussurea / Q000737:chemistry*; D012717:Sesquiterpenes / Q000032:analysis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D010936:Plant Extracts; D012717:Sesquiterpenes