title: Acute barium nitrate intoxication treated by hemodialysis.
abstract: A 22-year-old male was admitted to hospital with diarrhea and vomiting, cardiac arrhythmias, severe hypokalemia and gradual onset of muscular weakness. A potassium infusion was started, but for several hours serum potassium remained low. Evidence of toxic ingestion was initially lacking. When it became clear -- after a considerable delay -- that the patient had ingested barium nitrate, hemodialysis was started. This resulted in rapid clinical improvement with correction of hypokalemia and restored muscular function. Intoxication with barium causes hypokalemia, arrhythmias, muscular weakness and paralysis, often requiring respiratory support. This patient presented with symptoms typical of severe barium intoxication, non-responsive to potassium supplementation. There are few published reports on the use of hemodialysis in barium poisoning. This case confirms the possible benefit of hemodialysis in severe cases, where potassium supplementation alone is insufficient.
authors.affiliation: Department of Anesthesia and Intensive Care, Danderyd Hospital, Stockholm, Sweden. hans.bahlmann@ane.ds.sll.se
authors.forename: H
authors.initials: H
authors.lastname: Bahlmann
authors.forename: R
authors.initials: R
authors.lastname: Lindwall
authors.forename: H
authors.initials: H
authors.lastname: Persson
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D001464:Barium / Q000097:blood; D017609:Barium Compounds / Q000506:poisoning*; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000523:psychology; D003422:Critical Care; D003486:Cyanides / Q000506:poisoning; D004562:Electrocardiography; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D018908:Muscle Weakness / Q000139:chemically induced / Q000188:drug therapy; D009566:Nitrates / Q000506:poisoning*; D011188:Potassium / Q000097:blood / Q000627:therapeutic use; D006435:Renal Dialysis; D013406:Suicide, Attempted
chemical_list: D017609:Barium Compounds; D003486:Cyanides; D009566:Nitrates; D001464:Barium; C023545:barium nitrate; D011188:Potassium