The HLA locus and multiple sclerosis in Sicily.
The authors report the analysis of HLA-class II allelic heterogeneity in a well characterized multiple sclerosis (MS) Sicilian dataset. Family-based association analysis revealed evidence for excess transmission to affected individuals for alleles HLA-DRB1*1501, DRB1*04, and DQB1*0302. When analyzed as haplotypes, the authors observed excess transmission for the DRB1*0400-DQB1*0302 haplotype. Sicilian patients share the HLA-DRB1*1501 susceptibility allele with affected living in continental Italy, but also display the allelic heterogeneity that characterizes Mediterranean populations.
Brassat
D
D
Department of Neurology, School of Medicine, University of California at San Francisco, CA 94143-0435, USA.
Salemi
G
G
Barcellos
L F
LF
McNeill
G
G
Proia
P
P
Hauser
S L
SL
Oksenberg
J R
JR
Savettieri
G
G
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000483:Alleles; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D005787:Gene Frequency; D005788:Gene Pool; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D006681:HLA-D Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015994:Incidence; D015810:Linkage Disequilibrium; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000235:genetics; D015995:Prevalence; D012306:Risk; D012720:Severity of Illness Index; D012802:Sicily / Q000453:epidemiology
D006681:HLA-D Antigens