title: Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe.
abstract: A new diglucoside having a 5-methylchromone moiety was isolated from a commercial sample of Cape aloe, the dried exudate from Aloe ferox Miller, and named aloeresin I. Its structure was established as 1 on the basis of spectral and chemical evidence. Aloeresin I (1) (1 micromol/cm2) reduces in vivo the oedematous response (39 %) induced by Croton oil in the mouse ear with the same potency as aloesin, one of the most abundant Cape aloe constituents, and to a higher extent than aloeresin H (2). Indomethacin (0.3 micromol/cm2), the reference anti-inflammatory compound, provokes 61 % oedema inhibition.
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Universitá degli Studi di Milano, Italy. giovanna.speranza@unimi.it
authors.forename: G
authors.initials: G
authors.lastname: Speranza
authors.forename: C F
authors.initials: CF
authors.lastname: Morelli
authors.forename: A
authors.initials: A
authors.lastname: Tubaro
authors.forename: G
authors.initials: G
authors.lastname: Altinier
authors.forename: L
authors.initials: L
authors.lastname: Durì
authors.forename: P
authors.initials: P
authors.lastname: Manitto
mesh_terms: D000504:Aloe; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002867:Chromones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003436:Croton Oil; D004187:Disaccharides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones; D004187:Disaccharides; D010936:Plant Extracts; C497983:aloeresin I; D003436:Croton Oil