title: Serum cross-linked N-terminal telopeptide of type I collagen for evaluation of renal osteodystrophy in hemodialysis patients.
abstract: BACKGROUND
  Useful markers of bone resorption are needed for hemodialysis patients with renal osteodystrophy. This study investigated the use of a new immunoassay for cross-linked N-terminal telopeptide of type 1 collagen to assess bone changes in hemodialysis patients.
  
  
  METHODS
  Radial bone mineral density was examined in 178 hemodialysis patients at baseline and after 12 months. Serum levels of N-terminal telopeptide and other markers were measured.
  
  
  RESULTS
  The annual percent change of radial bone mineral density was negatively correlated with the levels of N-terminal telopeptide, intact osteocalcin, tartrate-resistant acid phosphatase, bone-specific alkaline phosphatase, and intact parathyroid hormone. The annual percent change of radial bone mineral density showed a stronger correlation with N-terminal telopeptide levels than with the other markers, except for intact parathyroid hormone. Also, intact parathyroid hormone and N-terminal telopeptide levels showed a stronger correlation than that of either tartrate-resistant acid phosphatase or cross-linked carboxyterminal telopeptide of type 1 collagen with intact parathyroid hormone.
  
  
  CONCLUSIONS
  Serum N-terminal telopeptide may be the most useful bone resorption marker in renal osteodystrophy and its use combined with bone formation markers may improve the management of this condition.
authors.affiliation: Department of Internal Medicine, Hakuai Hospital, Kure, Japan.
authors.forename: Ayumu
authors.initials: A
authors.lastname: Nakashima
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yorioka
authors.forename: Takashi
authors.initials: T
authors.lastname: Mizutani
authors.forename: Zentaro
authors.initials: Z
authors.lastname: Yamagata
authors.forename: Toshinori
authors.initials: T
authors.lastname: Ueno
authors.forename: Norihisa
authors.initials: N
authors.lastname: Takasugi
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000097:blood*; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000097:blood*; D006435:Renal Dialysis / Q000009:adverse effects*; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D024042:Collagen Type I; D007527:Isoenzymes; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D003094:Collagen; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase