title: Acyl sulfonamide anti-proliferatives. Part 2: activity of heterocyclic sulfonamide derivatives.
abstract: The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. mader_mary@lilly.com
authors.forename: Mary M
authors.initials: MM
authors.lastname: Mader
authors.forename: Chuan
authors.initials: C
authors.lastname: Shih
authors.forename: Eileen
authors.initials: E
authors.lastname: Considine
authors.forename: Alfonso De
authors.initials: AD
authors.lastname: Dios
authors.forename: Cora Sue
authors.initials: CS
authors.lastname: Grossman
authors.forename: Philip A
authors.initials: PA
authors.lastname: Hipskind
authors.forename: Ho-Shen
authors.initials: HS
authors.lastname: Lin
authors.forename: Karen L
authors.initials: KL
authors.lastname: Lobb
authors.forename: Beatriz
authors.initials: B
authors.lastname: Lopez
authors.forename: José E
authors.initials: JE
authors.lastname: Lopez
authors.forename: Luisa M Martin
authors.initials: LM
authors.lastname: Cabrejas
authors.forename: Michael E
authors.initials: ME
authors.lastname: Richett
authors.forename: Wesley T
authors.initials: WT
authors.lastname: White
authors.forename: Yiu-Yin
authors.initials: YY
authors.lastname: Cheung
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Huang
authors.forename: John E
authors.initials: JE
authors.lastname: Reilly
authors.forename: Sean R
authors.initials: SR
authors.lastname: Dinn
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014471:Umbilical Veins / Q000166:cytology; D042461:Vascular Endothelial Growth Factor A
chemical_list: D006574:Heterocyclic Compounds, 2-Ring; D013449:Sulfonamides; D042461:Vascular Endothelial Growth Factor A