title: Advances in childhood leukaemia: successful clinical-trials research leads to individualised therapy.
abstract: In most cases, childhood leukaemia has a fetal origin, but multiple molecular events are required after birth for pre-leukaemic cells to progress to leukaemia. Cure rates for acute lymphoblastic leukaemia (ALL) now approach 80%. A high level of minimal residual disease detected by polymerase chain reaction in patients with ALL in remission has profound prognostic importance and is the focus of a major Australian study attempting to prevent relapse in these children. Greater awareness of the late effects of chemotherapy has led to changes in the treatment protocols for ALL, with improvement in neurocognitive outcomes and reduced rates of second malignancies. Pharmacogenetics is a new field of research that aims to enhance treatment efficacy by assessing the individual's metabolism of and response to chemotherapeutic agents. Targeted therapies currently being developed show some promise of being able to further improve cure rates. Adolescents with ALL have a better prognosis if treated with paediatric rather than adult protocols.
authors.affiliation: Centre for Children's Cancer and Blood Disorders, Sydney Children's Hospital, Randwick, NSW, Australia.
authors.forename: David S
authors.initials: DS
authors.lastname: Ziegler
authors.forename: Luciano
authors.initials: L
authors.lastname: Dalla Pozza
authors.forename: Keith D
authors.initials: KD
authors.lastname: Waters
authors.forename: Glenn M
authors.initials: GM
authors.lastname: Marshall
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002648:Child; D016371:Cranial Irradiation / Q000009:adverse effects; D006801:Humans; D007938:Leukemia / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents