title: Sensitivity of Borrelia genospecies to serum complement from different animals and human: a host-pathogen relationship.
abstract: Different Borrelia species and serotypes were tested for their sensitivity to serum complement from various animals and human. Complement-mediated Borrelia killing in cattle, European bison and deer was higher irrespective of the Borrelia species whereas in other animals and human it was intermediate and Borrelia species-dependent. Activation of the alternative complement pathway by particular Borrelia strain was in correlation with its sensitivity or resistance. These results support the incompetent reservoir nature of cattle, European bison, red, roe and fallow deer, at the same time present the probable reservoir nature of mouflon, dog, wolf, cat and lynx. In short, this study reviews Borrelia-host relationship and its relevance in reservoir competence nature of animals.
authors.affiliation: Department of Epizootology and Infectious Diseases, University of Veterinary Medicine, Komenskeho-73, Kosice, Slovakia. mangeshbhide@hotmail.com
authors.forename: Mangesh R
authors.initials: MR
authors.lastname: Bhide
authors.forename: Milan
authors.initials: M
authors.lastname: Travnicek
authors.forename: Maria
authors.initials: M
authors.lastname: Levkutova
authors.forename: Jan
authors.initials: J
authors.lastname: Curlik
authors.forename: Viera
authors.initials: V
authors.lastname: Revajova
authors.forename: Mikulas
authors.initials: M
authors.lastname: Levkut
mesh_terms: D000818:Animals; D016164:Bison / Q000276:immunology; D001770:Blood Bactericidal Activity; D001898:Borrelia / Q000276:immunology*; D001899:Borrelia Infections / Q000276:immunology* / Q000662:veterinary; D002415:Cats; D002417:Cattle; D003170:Complement Pathway, Alternative; D003165:Complement System Proteins / Q000276:immunology*; D003670:Deer / Q000276:immunology; D004197:Disease Reservoirs; D004285:Dogs; D006790:Host-Parasite Interactions; D006801:Humans; D046008:Lynx / Q000276:immunology; D034561:Sheep, Domestic / Q000276:immunology; D019596:Wolves / Q000276:immunology
chemical_list: D003165:Complement System Proteins