title: Maintenance of interbody space in one- and two-level anterior cervical interbody fusion: comparison of the effectiveness of autograft, allograft, and cage.
abstract: The use of allografts, autologous iliac crest grafts, and cages for anterior cervical fusion is well documented, however there is no comparison regarding the effectiveness of maintaining the interbody space with the three approaches. We retrospectively measured the rate and amount of interspace collapse, segmental sagittal angulations, clinical results, and radiographic fusion success rates to determine which is the best fusion material. We assessed 73 patients who had one- and two-level cervical discectomies and interbody fusions without instrumentation. The three groups had similar clinical results and fusion rates. However, in the autograft group union occurred in 4 months. In the allograft group, union did not occur until 5.54 months. Moreover, the loss of cervical lordosis (2.75 degrees) was less in the cage group than in the allograft group (9.23 degrees). Additionally, the anterior interspace collapse (1.73 mm) in the cage group was less than the collapse recorded in the autograft group (2.82 mm) and in the allograft group (4 mm). An interspace collapse of 3 mm or greater was observed in 56.1% of the patients in the allograft group, compared with only 19% of the patients in the cage group. We showed that the cage is superior to the allograft and autograft in maintaining cervical interspace height and cervical lordosis after one-level and two-level anterior cervical decompression procedures.
  
  
  METHODS
  Therapeutic study, Level III-2 (retrospective cohort study).
authors.affiliation: Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
authors.forename: Feng-Chen
authors.initials: FC
authors.lastname: Kao
authors.forename: Chi-Chien
authors.initials: CC
authors.lastname: Niu
authors.forename: Lih-Huei
authors.initials: LH
authors.lastname: Chen
authors.forename: Po-Liang
authors.initials: PL
authors.lastname: Lai
authors.forename: Wen-Jer
authors.initials: WJ
authors.lastname: Chen
mesh_terms: D002574:Cervical Vertebrae / Q000601:surgery*; D015194:Diffusion Chambers, Culture; D017586:Diskectomy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011542:Pseudarthrosis / Q000209:etiology; D012189:Retrospective Studies; D013123:Spinal Fusion / Q000009:adverse effects / Q000379:methods*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D016896:Treatment Outcome