Oxidative stress and uremia.
Oxidative stress is a pathogenic element of great importance in uremic patients, with a great impact on their survival. The cause of oxidative stress in patients on hemodialysis is traditionally attributed to the recurrent activation of polymorphonucleate neutrophils and monocytes. The effects of oxidative stress are evident on all biochemical components of biological tissues: lipids, proteins, carbohydrates, and nucleic acids. This study briefly reviews the effects of different dialytic techniques and of kidney transplant on several parameters of oxidative stress. Many different modalities of pharmaceutical intervention are then analyzed, and the clinical evidences reported.
Floccari
Fulvio
F
Chair of Nephrology, Department of Internal Medicine, University of Messina, Italy.
Aloisi
Carmela
C
Crascì
Eleonora
E
Sofi
Tito
T
Campo
Susanna
S
Tripodo
Donatella
D
Criseo
Manila
M
Frisina
Nicola
N
Buemi
Michele
M
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D016030:Kidney Transplantation; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D011506:Proteins / Q000378:metabolism; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism* / Q000628:therapy
D000975:Antioxidants; D017127:Glycation End Products, Advanced; D011506:Proteins; D004247:DNA