Free radical lipid oxidation in brain cortex neurons and neuroglia during convulsions.
The amount of lipid peroxidation products (conjugated dienes and trienes and Schiff bases) in cortical neurons of the cerebral hemispheres decreased by 30% at the peak of convulsions observed 10-15 min after intraperitoneal injection of picrotoxin. In neuroglial cells of control animals the intensity of lipid peroxidation in was 1.7-2.0 times lower. Picrotoxin had no effect on this parameter.
Flerov
M A
MA
Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Tolstukhina
T I
TI
Gerasimova
I A
IA
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003292:Convulsants / Q000633:toxicity; D005609:Free Radicals / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010852:Picrotoxin / Q000633:toxicity; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
D003292:Convulsants; D005609:Free Radicals; D010852:Picrotoxin