title: Ultrastructure of internal limiting membrane in myopic foveoschisis.
abstract: OBJECTIVE
  To reveal the pathogenesis of myopic foveoschisis (MF).
  
  
  METHODS
  Clinicopathological report.
  
  
  METHODS
  Internal limiting membranes (ILMs) were collected from ten patients with MF and five patients with idiopathic macular hole (IMH) as a control. Samples were subjected to transmission electron microscopic study. Characteristics of the ILM were compared between the two groups.
  
  
  RESULTS
  Collagen fiber and cell debris were identified on the inner surface of ILM in seven eyes (70%) with MF, significantly more (P < .05) than found in IMH subjects (0%). More fibrous glial cells were likely to be found on the inner surface of ILM. No significant difference in fibroblast-like cell adhesion was observed.
  
  
  CONCLUSIONS
  Collagen fiber and cellular component are suggested to play an important role in developing MF. ILM peeling may be essential for vitrectomy for MF.
authors.affiliation: Department of Ophthalmology, Graduate School of Medicine, Osaka University, Osaka, Japan. bando@ophthal.med.osaka-u.ac.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Bando
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ikuno
authors.forename: Jun-Sub
authors.initials: JS
authors.lastname: Choi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tano
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yamanaka
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Ishibashi
mesh_terms: D000368:Aged; D001485:Basement Membrane / Q000648:ultrastructure; D003094:Collagen / Q000648:ultrastructure; D019773:Epiretinal Membrane / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009216:Myopia / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D009457:Neuroglia / Q000648:ultrastructure; D012167:Retinal Perforations / Q000473:pathology / Q000601:surgery; D041441:Retinoschisis / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D014821:Vitrectomy
chemical_list: D003094:Collagen