title: Is bare-metal stenting superior to balloon angioplasty for small vessel coronary artery disease? Evidence from a meta-analysis of randomized trials.
abstract: OBJECTIVE
  To compare, by meta-analytical techniques, the clinical impact of bare-metal stenting vs. balloon angioplasty for the treatment of lesions in small coronary arteries.
  
  
  RESULTS
  We included trials with random allocation and prospective comparison of angioplasty vs. stenting, reference vessel diameter<3 mm, and follow-up>or=6 months. Random effect odds ratios (OR) for death, myocardial infarction (MI), repeat revascularization (RR), and major adverse cardiac events (MACEs) were computed. In a pre-specified subgroup analysis, we compared stenting with optimal (post-procedural stenosis<20%) and suboptimal (>20%) angioplasty. Thirteen studies (4383 patients) were selected. No differences were found in terms of death and MI, while MACEs, mainly driven by RR, were significantly less common after stenting (17.6%) than after angioplasty (22.7%), OR 0.71 (0.57-0.90). Heterogeneity among trials was present. When considering only optimal angioplasty, MACE rates were homogeneously similar, 17.9 vs. 21.1%, OR 0.86 (0.66-1.11). If angioplasty were suboptimal, MACEs were significantly more common after angioplasty (24%) than after stenting (17.3%), OR 0.62 (0.44-0.88).
  
  
  CONCLUSIONS
  Stenting is superior to balloon angioplasty for the treatment of small vessels, in particular after suboptimal angioplasty. However, MACE and RR rates remain high after stenting, and the advantage of stent over angioplasty is moderate. An optimal balloon angioplasty strategy (with provisional stenting) may achieve results not inferior to routine stenting.
authors.affiliation: Department of Biomedical and Surgical Sciences, Section of Cardiology, University of Verona, Piazzale Stefani 1, 37126 Verona, Italy. agostonipf@genie.it
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Agostoni
authors.forename: Giuseppe G L
authors.initials: GG
authors.lastname: Biondi-Zoccai
authors.forename: Gabriele L
authors.initials: GL
authors.lastname: Gasparini
authors.forename: Maurizio
authors.initials: M
authors.lastname: Anselmi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Morando
authors.forename: Marco
authors.initials: M
authors.lastname: Turri
authors.forename: Antonio
authors.initials: A
authors.lastname: Abbate
authors.forename: Eugene P
authors.initials: EP
authors.lastname: McFadden
authors.forename: Corrado
authors.initials: C
authors.lastname: Vassanelli
authors.forename: Piero
authors.initials: P
authors.lastname: Zardini
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D003324:Coronary Artery Disease / Q000628:therapy*; D006801:Humans; D008670:Metals; D008875:Middle Aged; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D015607:Stents; D016896:Treatment Outcome
chemical_list: D008670:Metals