title: No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder.
abstract: OBJECTIVE
  Serotonin type 1A receptors (5HT1ARs) have been shown to be affected by stress in experimental animals and related to anxiety and depression in humans. In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD).
  
  
  METHODS
  Using positron emission tomography and the radioligand [18F]FCWAY, the authors compared 5HT1AR binding between patients with PTSD and healthy subjects.
  
  
  RESULTS
  No significant differences in 5HT1AR distribution volume, binding potential, or tracer delivery were found.
  
  
  CONCLUSIONS
  5HT1AR expression may not be altered in patients with PTSD.
authors.affiliation: Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892-2670, USA. bonneo@intra.nimh.nih.gov
authors.forename: Omer
authors.initials: O
authors.lastname: Bonne
authors.forename: Earle
authors.initials: E
authors.lastname: Bain
authors.forename: Alexander
authors.initials: A
authors.lastname: Neumeister
authors.forename: Allison C
authors.initials: AC
authors.lastname: Nugent
authors.forename: Meena
authors.initials: M
authors.lastname: Vythilingam
authors.forename: Richard E
authors.initials: RE
authors.lastname: Carson
authors.forename: David A
authors.initials: DA
authors.lastname: Luckenbaugh
authors.forename: William
authors.initials: W
authors.lastname: Eckelman
authors.forename: Peter
authors.initials: P
authors.lastname: Herscovitch
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Drevets
authors.forename: Dennis S
authors.initials: DS
authors.lastname: Charney
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D003510:Cyclohexanes; D005260:Female; D005462:Fluorine Radioisotopes; D015870:Gene Expression; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010879:Piperazines; D049268:Positron-Emission Tomography; D011869:Radioligand Assay; D044282:Receptor, Serotonin, 5-HT1A / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D013313:Stress Disorders, Post-Traumatic / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D003510:Cyclohexanes; D005462:Fluorine Radioisotopes; C493883:N-(2-(4-(2-methoxyphenyl)piperazino))-N-(2-pyridinyl) trans-4-fluorocyclohexanecarboxamide; D010879:Piperazines; D044282:Receptor, Serotonin, 5-HT1A