title: Comparison of radiation dose estimation for myeloablative radioimmunotherapy for relapsed or recurrent mantle cell lymphoma using (131)I tositumomab to that of other types of non-Hodgkin's lymphoma.
abstract: Patients with relapsed or refractory mantle cell lymphoma (MCL) demonstrate poor survival after standard treatment. Myeloablative radioimmunotherapy (RIT) using (131)I tositumomab (anti-CD20) has the ability to deliver specific radiation-absorbed dose to antigen-bearing tumor. We reviewed normal organ radiation- absorbed doses in MCL patients.
  
  
  METHODS
  Records of patients with MCL (n =25), who received myeloablative RIT between January 1996 and December 2003 were reviewed. Individual patient radiation dosimetry was performed on all patients after a trace-labeled infusion of (131)I tositumomab (mean = 348 MBq), to calculate the required amount of radioactivity for therapy, based on medical internal radiation dose (MIRD) schema.
  
  
  RESULTS
  Mean organ residence times (hour) corrected for computed tomography (CT) derived organ volumes for MCL, were as follows: Lungs: 9.0; Liver: 12.4; Kidneys: 1.7; Spleen: 2.17; Whole Body: 62.4 and mean radiation absorbed doses mGy/Mbq were: Lungs: 1.2; Liver: 1.1; Kidneys: 0.85; Spleen: 1.7; Whole Body: 0.21. This is similar to patients with other non-Hodgkin's lymphoma (NHL). Patients received a mean activity of 21 GBq of (131)I (range, 11.5-41.4) for therapy estimated to deliver 25 Gy to the normal organ receiving the highest radiation-absorbed dose.
  
  
  CONCLUSIONS
  Myeloablative RIT using (131)I tositumomab results in normal organ radiation-absorbed doses similar to those in patients with other non-Hodgkin's lymphoma, and is suitable for treating patients with relapsed or refractory MCL.
authors.affiliation: Department of Radiology, University of Washington, Seattle, WA 98195, USA. rajan@u.washington.edu
authors.forename: Joseph
authors.initials: J
authors.lastname: Rajendran
authors.forename: Ajay
authors.initials: A
authors.lastname: Gopal
authors.forename: Lawrence
authors.initials: L
authors.lastname: Durack
authors.forename: Darrell
authors.initials: D
authors.lastname: Fisher
authors.forename: Oliver
authors.initials: O
authors.lastname: Press
authors.forename: Janet
authors.initials: J
authors.lastname: Eary
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000276:immunology / Q000532:radiotherapy*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000532:radiotherapy; D019653:Myeloablative Agonists / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local; D009928:Organ Specificity; D011829:Radiation Dosage; D016499:Radioimmunotherapy; D014018:Tissue Distribution
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D019653:Myeloablative Agonists; C119496:tositumomab I-131