[The use of azithromycin in prophylaxis of respiratory infections occurred in the organized collectives, clinical sequelae].
The influence of azithromycin prophylaxis on clinical course of extra-hospitalpneumonia (EP) and efficiency of empirical antibiotic therapy was studied. During 5 months EP was diagnosed in 2 groups (prophylaxis and control) in 8.6% (47/548) and 20.2% (137/678) subjects respectively. Mild EP was diagnosed in all cases. No significant differences in EP clinical course between the groups were noted. The empirical therapy using benzylpenicillin was considered as effective in 90.5% [95% CI=84.3-94.9%] and in 89.4% [95% CI=76.9-96.5%] cases in the control group and group of prophylaxis respectively (P=0.84).
Klochkov
O I
OI
Guchev
I A
IA
Ivanitsa
G V
GV
D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D001996:Bronchopneumonia / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008889:Military Personnel; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D017963:Azithromycin