Immunoglobulin E-mediated reactions to corticosteroids.
Allergic reactions to steroids are rare, but are becoming more commonly recognized by clinicians. Although many reactions are thought to be IgE mediated, most are adverse drug reactions caused by nonallergic mechanisms, some related to additives in the steroid preparation being administered. Provocative challenge with the suspected offending agent, serologic tests for allergen-specific IgE, and skin testing are the most reliable methods for assessing hypersensitivity to steroids, although none is infallible. Therapeutic options for patients with documented steroid allergy include the use of alternative steroid preparations, desensitization, and, possibly, the use of monoclonal anti-IgE antibodies.
Cheam
Hay
H
Department of Pediatrics, University of California, Davis, Children's Hospital, 2516 Stockton Boulevard, Sacramento, CA 95817, USA.
Butani
Lavjay
L
D000305:Adrenal Cortex Hormones / Q000276:immunology* / Q000627:therapeutic use; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D010328:Patch Tests; D011379:Prognosis; D018570:Risk Assessment
D000305:Adrenal Cortex Hormones; D007073:Immunoglobulin E