Prevalence of mixed cryoglobulins in relation to CD4 cell count among patients coinfected with HIV and hepatitis C virus.
Cryoglobulinemia was studied in human immunodeficiency virus-positive, hepatitis C virus (HCV)-positive patients in relation to their CD4 cell count. Cryoglobulinemia was found in 18 (31.6%) of 57 patients: 17 (44.7%) of 38 patients with a CD4 cell count of >or=200 cells/ micro L versus 1 (5.3%) of 19 patients with a CD4 cell count of <200 cells/ micro L (P=.0064). Cell-mediated immunity could, therefore, contribute to the production of HCV-associated cryoglobulins.
Aaron
Laurent
L
Service des Maladies Infectieuses et Tropicales, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Necker Enfants-Malades, Paris, France.
Lebray
Pascal
P
Alyanakian
Marie-Alexandra
MA
Roudière
Laurent
L
Therby
Audrey
A
Chaix
Marie-Laure
ML
Dupont
Bertrand
B
Pol
Stanislas
S
Viard
Jean-Paul
JP
D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D003449:Cryoglobulinemia / Q000097:blood / Q000150:complications* / Q000209:etiology; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications*; D006526:Hepatitis C / Q000097:blood / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019562:Viral Load