title: Usefulness of latent left ventricular dysfunction assessed by Bowditch Treppe to predict stress-induced pulmonary hypertension in minimally symptomatic severe mitral regurgitation secondary to mitral valve prolapse.
abstract: We assessed whether the presence of latent myocardial dysfunction, evaluated by echocardiographic derived force-frequency relationship (FFR) during exercise, predicts the appearance of stress-induced pulmonary hypertension in minimally symptomatic patients with severe mitral regurgitation (MR). Two groups of patients were identified: group I with normal (</=40 mm Hg) and group II with abnormal (>40 mm Hg) peak stress systemic pulmonary artery pressure. Group I had normal and upsloping FFR and group II had abnormal flat or biphasic FFR. Therefore, in patients with severe MR and apparently normal left ventricular function, the stress-induced pulmonary hypertension seems to be related to the presence of latent left ventricular dysfunction.
authors.affiliation: Division of Non-Invasive Cardiology, Cardiothoracic Department, San Raffaele Hospital, IRCCS, Milano, Italy. agricola.eustachio@hsr.it
authors.forename: Eustachio
authors.initials: E
authors.lastname: Agricola
authors.forename: Tonino
authors.initials: T
authors.lastname: Bombardini
authors.forename: Michele
authors.initials: M
authors.lastname: Oppizzi
authors.forename: Alberto
authors.initials: A
authors.lastname: Margonato
authors.forename: Matteo
authors.initials: M
authors.lastname: Pisani
authors.forename: Giulio
authors.initials: G
authors.lastname: Melisurgo
authors.forename: Eugenio
authors.initials: E
authors.lastname: Picano
mesh_terms: D000704:Analysis of Variance; D017023:Coronary Angiography; D018618:Echocardiography, Doppler, Color; D005080:Exercise Test; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000000981:diagnostic imaging; D008945:Mitral Valve Prolapse / Q000150:complications* / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D012372:ROC Curve; D018709:Statistics, Nonparametric; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000000981:diagnostic imaging*