Two new hepatoprotective stilbene glycosides from Acer mono leaves.
Two new stilbene glycosides, 5-O-methyl-(E)-resveratrol 3-O-beta-d-glucopyranoside (1) and 5-O-methyl-(E)-resveratrol 3-O-beta-D-apiofuranosyl-(1-->6)-beta-d-glucopyranoside (2), were isolated from the leaves of Acer mono, along with seven known compounds. Among these compounds, 1, 2, and quercetin (3) showed significant hepatoprotective activities against H(2)O(2)-induced toxicity in primary cultures of rat hepatocytes.
Yang
Hyekyung
H
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Sillim-Dong, Gwanak-Gu, Seoul 151-742, Korea.
Sung
Sang Hyun
SH
Kim
Young Choong
YC
D031002:Acer / Q000737:chemistry*; D000818:Animals; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000633:toxicity; D007723:Korea; D008297:Male; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011794:Quercetin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C498131:5-O-methyl-(E)-resveratrol 3-O-beta-D-glucopyranoside; C498130:5-O-methyl-(E)-resveratrol-3-O-beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside; D005960:Glucosides; D006027:Glycosides; D013267:Stilbenes; D011794:Quercetin; D006861:Hydrogen Peroxide