Nucleoside-based phospholipids and their liposomes formed in water.
Phospholipids and liposomes have been the subjects of considerable attention because of their importance in biological systems. We have efficiently synthesized novel nucleoside-based phospholipids in six-step sequences starting from their corresponding nucleosides. These nucleoside-based phospholipids self-assemble into liposome-like structures in aqueous solutions. We have analyzed the structures of these liposomes by dynamic light scattering, transmission electron microscopy, and confocal microscopy.
Choi
Seung Kyu
SK
Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang 790-784, South Korea.
Vu
Tran Khac
TK
Jung
Jin Mi
JM
Kim
Su Jeong
SJ
Jung
Hun Rok
HR
Chang
Taihyun
T
Kim
Byeang Hyean
BH
D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry*; D010743:Phospholipids / Q000138:chemical synthesis / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D005456:Fluorescent Dyes; D008081:Liposomes; D009705:Nucleosides; D010743:Phospholipids; D014867:Water; D016650:Fluorescein-5-isothiocyanate