Stereoselective oxidation of protected inositol derivatives catalyzed by inositol dehydrogenase from Bacillus subtilis.
Inositol dehydrogenase (EC 1.1.1.18) from Bacillus subtilis is shown to have a nonpolar cavity adjacent to the active site, allowing racemic protected inositol derivatives such as 4-O-benzyl-myo-inositol to be recognized with very high apparent stereoselectivity.
Daniellou
Richard
R
Department of Chemistry, University of Saskatchewan, Canada.
Phenix
Christopher P
CP
Tam
Pui Hang
PH
Laliberte
Michael C
MC
Palmer
David R J
DR
D001412:Bacillus subtilis / Q000201:enzymology*; D002236:Carbohydrate Conformation; D002384:Catalysis; D007294:Inositol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013401:Sugar Alcohol Dehydrogenases / Q000737:chemistry*
D007294:Inositol; D013401:Sugar Alcohol Dehydrogenases; C021448:myo-inositol 2-dehydrogenase