Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions.
Neurotrophins regulate growth, survival, and differentiation of central neurons. In addition to the "classical" effects that are relatively slow neurotrophins also elicit rapid signaling that modulates a variety of cellular functions such as membrane excitability, synaptic transmission, and activity-dependent synaptic plasticity. These rapid actions are mediated mainly through the interaction of Trk receptors with ion channels and ionotropic receptors in the plasma membrane.
Blum
Robert
R
Institut für Physiologie, Ludwig-Maximilians-Universität München, Germany.
Konnerth
Arthur
A
D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D009414:Nerve Growth Factors / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D013997:Time Factors
D007473:Ion Channels; D009414:Nerve Growth Factors; D018377:Neurotransmitter Agents