title: Update in bioinformatics. Toward a digital database of plant cell signalling networks: advantages, limitations and predictive aspects of the digital model.
abstract: The process of signal integration, which contributes to the regulation of multiple cellular activities, can be described in a digital language by a set of connected digital operations. In this article we delineate the basic concepts of cell signalling in the context of a logical description of information processing. Newly described instances of signal integration in plants are given as examples. The different advantages, limitations and predictive aspects of the digital modeling of signal transduction networks, as well as the minimal architecture of a computer database for plant signalling networks are discussed.
authors.affiliation: Department of Biology, University of Fribourg, Rte Albert Gockel 3, 1700 Fribourg, Switzerland.
authors.forename: Marcela Beatriz
authors.initials: MB
authors.lastname: Treviño Santa Cruz
authors.forename: Dominique
authors.initials: D
authors.lastname: Genoud
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Métraux
authors.forename: Thierry
authors.initials: T
authors.lastname: Genoud
mesh_terms: D019295:Computational Biology; D016208:Databases, Factual; D008954:Models, Biological; D010944:Plants / Q000378:metabolism*; D015398:Signal Transduction