Early events in antigen-specific regulatory T cell induction via nasal and oral mucosa.
Mucosal Tr prevent harmful immune responses to innocuous antigens that are encountered at the mucosae. This unique subset of Tr is adaptive, antigen specific, and suppresses irrespective of cytokine polarization. Here we study the earliest events of mucosal Tr induction and factors that control their differentiation from naive T cells.
Samsom
Janneke N
JN
Department of Molecular Cell Biology and Immunology, VUMC, FdG, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands. jn.samsom@vumc.nl
Hauet-Broere
Femke
F
Unger
Wendy W J
WW
VAN Berkel
Lisette A
LA
Kraal
Georg
G
D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000276:immunology*; D002454:Cell Differentiation; D018928:Immunity, Mucosal / Q000276:immunology*; D007273:Injections, Intramuscular; D008198:Lymph Nodes / Q000276:immunology; D009061:Mouth Mucosa / Q000276:immunology*; D009297:Nasal Mucosa / Q000276:immunology*; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D010047:Ovalbumin