Limb salvage management of pathologic fractures of primary malignant bone tumors.
BACKGROUND
Little is known about oncologic outcomes of patients with primary bone tumors complicated by a pathologic fracture and treated by limb salvage.


METHODS
Our study included 17 men and 14 women aged 6 to 61 years (average age 17 years). All 31 patients had primary bone tumors complicated by a pathologic fracture. Diagnoses included osteosarcoma (17 patients), Ewing's sarcoma (10), malignant fibrous histiocytoma (3), and lymphoma (1). All received preoperative chemotherapy. The distal femur was affected in 13 patients, the proximal femur in 6, mid shaft femur in 4, the proximal humerus in 4, the proximal tibia in 3, and the fibula in 1. All patients underwent limb salvage and achieved a wide resection margin.


RESULTS
The average follow-up period was 18 months (range 8 to 51 months). Two patients required amputation due to local recurrence. Six patients developed pulmonary metastases and eventually died.


CONCLUSIONS
A pathologic fracture of primary bone tumor is not always a contraindication for limb salvage since the oncologic outcome appears acceptable.
Ebeid
Walid
W
Cairo University, 38 Syria Street, Mohandseen, Cairo, Egypt. walidebeid@yahoo.com
Amin
Sherif
S
Abdelmegid
Amr
A
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000150:complications* / Q000473:pathology; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000209:etiology* / Q000601:surgery*; D006801:Humans; D023821:Limb Salvage / Q000379:methods*; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D016896:Treatment Outcome