title: Antimicrobial susceptibility survey of Streptococcus pyogenes isolated in Japan from patients with severe invasive group A streptococcal infections.
abstract: We assessed antimicrobial susceptibility against 211 Streptococcus pyogenes strains isolated from patients with severe invasive group A streptococcal infections. Overall, 3.8, 1.4, 1.4, and 0.5% of the isolates were resistant to erythromycin, clindamycin, telithromycin, and ciprofloxacin, respectively, and 10.4% had intermediate resistance to ciprofloxacin. All isolates were susceptible to ampicillin and cefotaxime.
authors.affiliation: Department of Bacteriology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Ikebe
authors.forename: Kyoko
authors.initials: K
authors.lastname: Hirasawa
authors.forename: Rieko
authors.initials: R
authors.lastname: Suzuki
authors.forename: Junko
authors.initials: J
authors.lastname: Isobe
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tanaka
authors.forename: Chihiro
authors.initials: C
authors.lastname: Katsukawa
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kawahara
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tomita
authors.forename: Kikuyo
authors.initials: K
authors.lastname: Ogata
authors.forename: Miyoko
authors.initials: M
authors.lastname: Endoh
authors.forename: Rumi
authors.initials: R
authors.lastname: Okuno
authors.forename: Haruo
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004591:Electrophoresis, Polyacrylamide Gel; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D013290:Streptococcal Infections / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004917:Erythromycin; C025651:CCCGGG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific