New developments in diagnosis and treatment of Parkinson's disease--from basic science to clinical applications.
In this review we summarize new developments in early diagnosis, establishing surrogate markers, genetics, neuroprotection and cell replacement in Parkinson's disease. Furthermore, we discuss the major problems in the translation of results from preclinical research into successful clinical trials.
Storch
Alexander
A
Technical University of Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany. alexander.storch@neuro.med.tu-dresden.de
Hofer
Anne
A
Krüger
Rejko
R
Schulz
Jörg B
JB
Winkler
Jürgen
J
Gerlach
Manfred
M
D015415:Biomarkers / Q000032:analysis; D003952:Diagnostic Imaging / Q000379:methods / Q000639:trends; D006801:Humans; D009414:Nerve Growth Factors / Q000494:pharmacology / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D010300:Parkinson Disease / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods / Q000639:trends; D017211:Treatment Failure
D015415:Biomarkers; D009414:Nerve Growth Factors; D018696:Neuroprotective Agents