Reactivity of alveolar macrophages during granulomatous inflammation of the lungs under conditions of acute massive blood loss.
Reactivity of mouse alveolar macrophages by their ability to phagocytize killed St. aureus bacteria and production of reactive oxygen metabolites (nitro blue tetrazolium test) in response to zymosan administration was studied under normal conditions and after acute massive blood loss. Zymosan-induced granulomatous inflammation of the lungs during acute massive blood loss 2-fold inhibited the increase in oxidative metabolism of alveolar macrophages. Suppressed production of toxic oxygen radicals in alveolar macrophages was accompanied by accelerated recovery of cells on the surface of the respiratory tract.
Makarova
O P
OP
Laboratory of Pathophysiology, Research Center for Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. opmak@cyber.ma.nsc.ru
Zubakhin
A A
AA
D000818:Animals; D015769:Granuloma, Respiratory Tract / Q000139:chemically induced / Q000150:complications / Q000276:immunology*; D006470:Hemorrhage / Q000150:complications*; D008168:Lung / Q000187:drug effects; D016676:Macrophages, Alveolar / Q000276:immunology* / Q000382:microbiology; D008297:Male; D051379:Mice; D010587:Phagocytosis / Q000502:physiology*; D011014:Pneumonia / Q000139:chemically induced / Q000150:complications / Q000276:immunology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013211:Staphylococcus aureus; D015054:Zymosan / Q000494:pharmacology
D017382:Reactive Oxygen Species; D015054:Zymosan