Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell line.
The authors have developed a class of potent inhibitors against the phosphate specific prolyl isomerase hPin1, which induced apoptosis in transformed cell lines.
Bayer
Elena
E
Molecular and Structural Biophysics, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Str. 11, D-44227 Dortmund, Germany.
Thutewohl
Michael
M
Christner
Claudia
C
Tradler
Thomas
T
Osterkamp
Frank
F
Waldmann
Herbert
H
Bayer
Peter
P
D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000037:antagonists & inhibitors*; D018631:ras Proteins / Q000378:metabolism*
D004791:Enzyme Inhibitors; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D018631:ras Proteins; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase