title: Successful treatment of retrograde ejaculation with the alpha1-adrenergic agonist methoxamine: case study.
abstract: We treated two patients affected by retrograde ejaculation (RE) with the pure alpha1-adrenergic agonist methoxamine; the drug was self-administered intramuscularly by the patients 30 min prior to intercourse or masturbation. A previous trial with oral imipramine had been ineffective in both patients. Sperm count increased substantially, particularly in the first patient who had insulin-dependent diabetes and was seeking fertility. In this patient, total ejaculated sperm increased from 22 millions to 488 and 419.5 millions on two different occasions, with good motility; two clinical pregnancies were obtained in the partner of this patient after 3 and 4 months of treatment, respectively. The second patient did not desire fertility. In both patients, no side effects were seen except for slight piloerection; blood pressure values increased slightly, and heart rate was unchanged. We conclude that self-administered methoxamine can be a useful, noninvasive and inexpensive treatment of RE, when oral agents are ineffective.
authors.affiliation: Dipartimento-Struttura Clinica Medica-Patologia Speciale Medica, Università di Sassari, Sassari, Italy. ptomasi@uniss.it
authors.forename: P A
authors.initials: PA
authors.lastname: Tomasi
authors.forename: G
authors.initials: G
authors.lastname: Fanciulli
authors.forename: G
authors.initials: G
authors.lastname: Delitala
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D004542:Ejaculation; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000209:etiology*; D007273:Injections, Intramuscular; D008297:Male; D008729:Methoxamine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012646:Self Administration; D013076:Sperm Count; D013081:Sperm Motility
chemical_list: D000316:Adrenergic alpha-Agonists; D008729:Methoxamine