title: Sucrose-induced translational repression of plant bZIP-type transcription factors.
abstract: Sugars as signalling molecules exert control on the transcription of many plant genes. Sugar signals also alter mRNA and protein stability. Increased sucrose concentrations specifically repress translation of the S-class basic region leucine zipper (bZIP) type transcription factor AtbZIP11/ATB2. This sucrose-induced repression of translation (SIRT) depends on translation of a highly conserved upstream open reading frame (uORF) in the 5' UTR of the gene. This conserved uORF is exclusively encoded in 5' UTRs of several plant S-class bZIP transcription factors. Arabidopsis homologues of ATB2/AtbZIP11, which harbour the conserved uORF, also show SIRT. Therefore, SIRT emerges as a general sucrose translational control mechanism of a group of transcription factors. SIRT might be part of a sucrose-specific signalling pathway, controlling expression of plant bZIP transcription factor genes.
authors.affiliation: Molecular Plant Physiology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Wiese
authors.forename: N
authors.initials: N
authors.lastname: Elzinga
authors.forename: B
authors.initials: B
authors.lastname: Wobbes
authors.forename: S
authors.initials: S
authors.lastname: Smeekens
mesh_terms: D016366:Open Reading Frames; D010944:Plants / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000502:physiology*; D013395:Sucrose / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors; D013395:Sucrose