Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population.
Low incidence of cancer in schizophrenia is one of the interesting puzzles in psychiatric field over decades. Analysis of genetic difference between schizophrenia and lung cancer might provide us with possible clues to understand molecular mechanisms of pathophysiology of schizophrenia. Epidermal growth factor (EGF), one of the potent growth promoting factors, has been studied for its roles in cancer development. EGF is also known to be involved in cognitive function. In order to analyze the genetic difference between schizophrenia and lung cancer, polymorphism of EGF gene was studied from 174 schizophrenia patients, 122 lung cancer patients and 132 controls in Korean population. Genotype frequency analysis of EGF gene (AluI restriction site, 5'-UTR, rs4444903) in the EGF gene was studied. The genotype and allele frequencies of the AluI polymorphism showed significant differences between schizophrenia and lung cancer patients [p<0.0001; p<0.0001, odds ratio (95% CI), 0.3690 (0.2600-0.5236)]. When compared with controls, schizophrenia patients showed no significant differences from controls in genotype and allele frequencies [p=0.5151; p=0.3516, odds ratio (95% CI), 0.8589 (0.6235-1.1830)]. However, lung cancer patients showed significant differences from controls in genotype and allele frequencies [p<0.0001; p<0.0001, odds ratio (95% CI), 2.3275 (1.6082-3.3687)]. These results indicate that schizophrenia is not associated with AluI polymorphism of EGF gene and EGF gene polymorphism is different between schizophrenia and lung cancer patients.
Lim
Yun Jeong
YJ
Department of Center for Health Promotion, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 135-710, South Korea.
Kim
Jong-Woo
JW
Song
Ji Young
JY
Hong
Mee-Suk
MS
Jin
Sheng-Yu
SY
Yoon
Seo Hyun
SH
Park
Hae Jeong
HJ
Choe
Bong-Keun
BK
Lee
Jung Joo
JJ
Yim
Sung-Vin
SV
Hong
Seok-Il
SI
Baik
Hyung Hwan
HH
Ha
Eunyoung
E
Park
Yeon Hee
YH
D020121:5' Untranslated Regions / Q000235:genetics; D000328:Adult; D016022:Case-Control Studies; D004815:Epidermal Growth Factor / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea / Q000208:ethnology; D008175:Lung Neoplasms / Q000208:ethnology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012150:Polymorphism, Restriction Fragment Length; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*
D020121:5' Untranslated Regions; D004815:Epidermal Growth Factor