title: Body mass index and the risk of male cancer mortality of various sites: 17-year follow-up of the Basel cohort study.
abstract: OBJECTIVE
  There is growing evidence for a link between body weight and cancer risk, but there is not a clear consensus yet.
  
  
  METHODS
  We studied the association between body mass index (BMI) and overall, lung, prostate and colon cancer mortality. In 1971/73, weight and height were measured in 2974 men working in Basel, Switzerland. In 1990, the vital status of all participants was assessed.
  
  
  RESULTS
  290 men had died from cancer, 87 from lung, 30 from prostate, and 22 from colon cancer. In the predefined Cox Proportional Hazards Regression Models for survival analysis, a baseline hazard was modified multiplicatively by covariates, i.e. the untransformed continuous variable "BMI" was chosen as covariate. In addition it was assumed that the baseline hazard may be different for smokers, non-smokers and different age groups (age at entry into study). Thus, multiple strata, i.e. combinations of smoking status and age groups were allowed. With increasing BMI overall cancer mortality did not change. Accordingly, the relative risk (RR) per 1-unit increase of BMI (unit = 1 kg/m2) was 1.03 (95% CI: 0.99-1.07). In relation to lung cancer, mortality did neither increase nor decrease with increasing BMI (RR = 1.0; 95% CI 0.93- 1.07). The results for prostate cancer mortality were similar, i.e. no correlation with BMI was observed (RR = 0.95; 95% CI: 0.93-1.18). The same was true for colon cancer mortality (RR = 1.09; 95% CI: 0.92-1.24).
  
  
  CONCLUSIONS
  This investigation provides little evidence of an association between BMI and mortality of all cancers combined, cancer of the lung, the prostate and the colon.
authors.affiliation: Institute for social and preventive medicine, University of Zurich, Switzerland. monika.eichholzer@balcab.ch
authors.forename: Monika
authors.initials: M
authors.lastname: Eichholzer
authors.forename: Florence
authors.initials: F
authors.lastname: Bernasconi
authors.forename: Paul
authors.initials: P
authors.lastname: Jordan
authors.forename: Hannes B
authors.initials: HB
authors.lastname: Stähelin
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003110:Colonic Neoplasms / Q000209:etiology / Q000401:mortality*; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000209:etiology / Q000401:mortality*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D016019:Survival Analysis; D013557:Switzerland / Q000453:epidemiology