Automated morphometric analysis of the cat retinal alpha/Y, beta/X and delta ganglion cells using wavelet statistical moment and clustering algorithms.
Computational morphological analysis comprises the development of measures (indicators) that describe different form attributes of a neuron and provides additional parameters for classification algorithms. Our work addressed the problem of small group sizes often encountered in neuromorphological and neurophysiological research, automated classification tasks (unsupervised learning) and introduced a new morphological measure: the wavelet statistical moment. We analysed cat alpha/Y, beta/X and delta Golgi-stained retinal ganglion cells using six different shape features (circularity, 2(nd) statistical moment and entropy of Gaussian blurred images, wavelet statistical moment, number of terminations and the fractal dimension). This allowed us to compare the sensitivity of the methods in uniquely describing morphological attributes of these cells.
Jelinek
Herbert F
HF
School of Community Health, Charles Sturt University, Australia. hjelinek@csu.edu.au
Cesar
Roberto M
RM
Leandro
Jorge J G
JJ
Spence
Ian
I
D000465:Algorithms; D000818:Animals; D002415:Cats; D016000:Cluster Analysis; D003712:Dendrites / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000166:cytology* / Q000502:physiology