title: Going in GTP cycles in the nucleolus.
abstract: Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways. The uncovered mechanism also implies that localization is determined by increased retention rather than directed targeting.
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. mistelit@mail.nih.gov
authors.forename: Tom
authors.initials: T
authors.lastname: Misteli
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism*; D002466:Cell Nucleolus / Q000378:metabolism*; D002467:Cell Nucleus / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D049109:Cell Proliferation; D019204:GTP-Binding Proteins; D006160:Guanosine Triphosphate / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D042581:Intranuclear Space / Q000378:metabolism; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism*; D011485:Protein Binding; D021381:Protein Transport / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D002352:Carrier Proteins; C469949:GNL3 protein, human; D009687:Nuclear Proteins; D006160:Guanosine Triphosphate; D019204:GTP-Binding Proteins