[Renal tubular protection of shenqi fuzheng injection in treating primary nephrotic syndrome].
OBJECTIVE
To explore the effect and mechanism of Shenqi Fuzheng injection (SFI) on renal tubule in treating patients with primary nephrotic syndrome (PNS).


METHODS
Eighty patients with PNS were randomly divided into two groups, 40 patients in the control group were treated by conventional therapy mainly with glucocorticoids; 40 patients in the treated group treated by conventional therapy plus intravenous injection of SFI additionally. The changes of serum albumin (sALB), urinary protein in 24 hrs (UP/24h), urinary levels of retinal binding protein (RBP), beta2 microglobulin (beta2-MG) and N-acetyl-D-glucosaminidase (NAG) as well as blood lipids before and after treatment were observed.


RESULTS
After treatment, level of sALB increased and urinay levels of RBP, beta2-MG, NAG, UP/24h decreased in the treated group, as compared with those in the control group, showing significant difference (P < 0.05 or P < 0.01). Blood lipids level abated significantly after treatment in both groups (P < 0.01), comparison between them, levels of TC and LDL-C in the treated group were significantly lower than those in the control group (P < 0.01).


CONCLUSIONS
SFI has protective effect on renal tubule in patients with PNS, also has effect on lowering blood lipids.
Huang
Yan-Yan
YY
Department of Nephrology, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563000. huangyanyan0097@163.com
Liu
Yong
Y
Liu
Chun-Mei
CM
D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000652:urine; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000652:urine; D008517:Phytotherapy; D011241:Prednisone / Q000627:therapeutic use*; D001613:beta 2-Microglobulin / Q000652:urine
D004365:Drugs, Chinese Herbal; D001613:beta 2-Microglobulin; D011241:Prednisone