Effects of phenolic acid esters and amides on stimulus-induced reactive oxygen species production in human neutrophils.
BACKGROUND
Phenolic acids and their derivatives are widely distributed in plants. A series of phenolic acid esters and amides have been synthesized.


METHODS
We determined the effects of phenolic acid derivatives on antiinflammatory activity against phorbol 12-myristate 13-acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced production of superoxide anion, an inflammatory mediator produced by neutrophils.


RESULTS
When the cells were preincubated with phenolic acids and their derivatives, the superoxide generation induced by fMLP (1.0 micromol/l) and PMA (0.16 micromol/l) was inhibited to various degrees with compounds 1, 2 and 4 significantly suppressing such generation in a concentration-dependent manner.


CONCLUSIONS
Phenolic acid derivatives may exert their antiinflammatory action through inhibiting superoxide generation.
Lee
Ya-Ting
YT
Department of Pharmacology, National Yang-Ming University, No. 155, Sec 2, Shih-Pai, Li-Nung Street, Peitou, Taipei 112, Taiwan, ROC.
Don
Ming-Jaw
MJ
Liao
Chang-Hui
CH
Chiou
Hua-Wen
HW
Chen
Chieh-Fu
CF
Ho
Li-Kang
LK
D000577:Amides / Q000494:pharmacology*; D004952:Esters; D006801:Humans; D062385:Hydroxybenzoates / Q000494:pharmacology*; D018836:Inflammation Mediators / Q000097:blood* / Q000502:physiology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000097:blood*; D013481:Superoxides / Q000097:blood
D000577:Amides; D004952:Esters; D062385:Hydroxybenzoates; D018836:Inflammation Mediators; D017382:Reactive Oxygen Species; D013481:Superoxides; C017616:phenolic acid