Effect of corticosteroids on short-term and long-term memory.
The effect of acute high-dose glucocorticoid therapy on memory function in patients with acute optic neuritis (n = 9) and multiple sclerosis (n = 21) was studied. All patients had reversible impairment of long-term memory functions, whereas measures of short-term memory, attentional functions, and alertness remained unaffected.
Brunner
R
R
Department of Neurology, University of Heidelberg, Germany.
Schaefer
D
D
Hess
K
K
Parzer
P
P
Resch
F
F
Schwab
S
S
D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001288:Attention / Q000187:drug effects; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced* / Q000503:physiopathology; D008570:Memory, Short-Term / Q000187:drug effects; D011939:Mental Recall / Q000187:drug effects; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000523:psychology; D009483:Neuropsychological Tests; D009902:Optic Neuritis / Q000188:drug therapy* / Q000523:psychology; D013312:Stress, Physiological / Q000523:psychology; D014706:Verbal Learning / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone