[Gene expression of type X collagen in the intervertebral disc of idiopathic scoliosis patients].
OBJECTIVE
To observe the characteristics of gene expression of type X collagen in the cartilage of end-plate and the fibrous annulus in the intervertebral disc of idiopathic scoliosis (IS) patients.


METHODS
Investigating the expression of type X collagen in the peak disc and the lower end disc of 21 IS patients, the peak disc of 16 congenital scoliosis (CS) and the lumbar disc of 3 normal people (according with the principle of medical ethnics) by reverse transcript polymerase chain reaction.


RESULTS
The expression of type X collagen in the concave side of IS peak disc was higher than the convex side (P < 0.05). There was no significant difference of gene expression of type X collagen between the convex side and the concave side of the lower end disc (P > 0.05). The gene expression of type X collagen in the IS peak disc was higher than those of lower end disc (P < 0.05). For the CS peak discs, the expression of type X collagen of the concave side was higher than the convex side (P < 0.05).


CONCLUSIONS
The expression of type X collagen of the IS peak disc increases, and the expression of type X collagen of the concave side is higher than the convex side. These changes may be secondary.
Lin
Qi
Q
Department of Orthopaedic Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Wu
Zhi-Hong
ZH
Liu
Yong
Y
Wang
Yi-Peng
YP
Weng
Xi-Sheng
XS
Lin
Jin
J
Tian
Ye
Y
Shen
Jian-Xiong
JX
Zhao
Hong
H
Zhang
Jian-Guo
JG
Qiu
Gui-Xing
GX
D000293:Adolescent; D002648:Child; D024121:Collagen Type X / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism*; D008297:Male; D012600:Scoliosis / Q000235:genetics / Q000378:metabolism*
D024121:Collagen Type X