Epidemiology, pathophysiology, and treatment of Barrett's esophagus: reducing mortality from esophageal adenocarcinoma.
The definition of BE has evolved over time. BE is the key premalignant lesion for developing EAC. The epidemiology and pathophysiology of BE is outlined, and risk factors for BE and EAC are reviewed. GERD plays a crucial role in the pathophysiology and the clinical identification of BE. Endoscopy with biopsy is the best tool for diagnosing and surveying patients with BE. Detection of early neoplasia is the present approach to reduce EAC mortality. Novel technology should assist in the early detection of dysplasia to enable targeted therapy. Effective chemopreventive strategies may reduce the risk of progression to EAC.
Sampliner
Richard E
RE
Section of Gastroenterology, Southern Arizona Veterans Affairs Health Care System, 3601 South 6th Avenue, Tucson, AZ 85723, USA. samplinr@emial.arizona.edu
D000230:Adenocarcinoma / Q000401:mortality*; D001471:Barrett Esophagus / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D004938:Esophageal Neoplasms / Q000401:mortality*; D006801:Humans