Adjusting drug diffusivity using miscible polymer blends.
Tuning the release rates of drugs was accomplished with miscible polymer blends. Dexamethasone (DX) was formulated in a miscible polymer blend composed of two poly(ether urethane)s, one in which DX diffuses relatively quickly and the other in which DX diffuses relatively slowly. Matrices that provide drug diffusion coefficients from 7 x 10(-13) to 3 x 10(-19) cm2/s were obtained by adjusting the blend ratio. Tunable diffusion coefficients were also achieved with partially miscible blends, such as poly(vinyl acetate) (PVAC)/cellulose acetate butyrate (CAB). However, similar tunable diffusion was not observed with an immiscible polymer blend composed of poly(carbonate urethane) (PCU) and polysulfone (PSF).
Lyu
Su-Ping
SP
Medtronic Technology Center LT 140, 710 Medtronic Parkway NE, Minneapolis, MN 55432, USA. suping.lyu@medtronic.com
Sparer
Randall
R
Hobot
Christopher
C
Dang
Kiem
K
D004058:Diffusion; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012996:Solutions
D004364:Pharmaceutical Preparations; D011108:Polymers; D012996:Solutions