title: Effects of azinphos-methyl on cholinergic responses and general health in zebra finches (Taeniopygia guttata) after previous treatment with p,p'-DDE.
abstract: Although organochlorine (OC) pesticides were replaced with organophosphates (OPs) in the early 1970s, they continue to persist in orchard environments today. Extensive research has been conducted to determine the effects of currently used OPs on cholinesterase (ChE) activity; however, although OCs continue to be prevalent in areas of previous use, few studies have looked at the toxicity of a combination of residual OC compounds with currently used OP pesticides. The focus of our study was to determine the effects of azinphos-methyl (a common OP used in apple orchards today) on ChE activity and general health in zebra finches (Taeniopygia guttata) previously exposed to p,p'-DDE (a commonly detected metabolite of DDT). The main results of our study were as follows: (1) azinphos-methyl alone caused a dose-dependent inhibition of plasma and brain ChE activity; (2) p,p'-DDE in combination with azinphos-methyl did not change azinphos-methyl inhibition of ChE activity; and (3) there were suggestions of immunostimulation in birds dosed 1 year previously to p,p'-DDE and of anemia when p,p'-DDE was combined with azinphos-methyl; however, there was no dose-response for these parameters in birds subsequently dosed with p,p'-DDE.
authors.affiliation: Agroecology Group, Faculty of Agricultural Sciences, University of British Columbia, 2357 Main Mall, Vancouver, British Columbia, V6T 1Z4, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Gill
authors.forename: T D
authors.initials: TD
authors.lastname: Williams
authors.forename: C A
authors.initials: CA
authors.lastname: Bishop
authors.forename: K M
authors.initials: KM
authors.lastname: Cheng
authors.forename: J E
authors.initials: JE
authors.lastname: Elliott
mesh_terms: D000818:Animals; D001387:Azinphosmethyl / Q000008:administration & dosage / Q000633:toxicity*; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D002802:Cholinesterases / Q000097:blood; D003633:Dichlorodiphenyl Dichloroethylene / Q000008:administration & dosage; D046369:Finches / Q000097:blood / Q000502:physiology*; D006400:Hematocrit; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D012098:Reproduction; D012882:Skin Tests
chemical_list: D002800:Cholinesterase Inhibitors; D007306:Insecticides; D010835:Phytohemagglutinins; D001387:Azinphosmethyl; D003633:Dichlorodiphenyl Dichloroethylene; D002802:Cholinesterases