Effects of terguride treatment on glucose abnormalities induced by ischemic brain damage in SHR/N-cp lean Koletsky strain and in rats of Wistar strain.
BACKGROUND
Severe head injury is associated with a stress response that includes hyperglycemia, which has been shown in both experimental and clinical studies to exacerbate the severity of brain injury during ischemic conditions.


OBJECTIVE
This study evaluated the possible protective effect of Terguride (trans-dihydrolisuride) on glucose metabolism against hyperglycemia.


METHODS
The experiments were performed in male and female rats of Wistar and Koletsky strain. Glucose intolerance was induced in both strains by 4-hour-occlusion of both common carotid arteries followed by 44-hour reperfusion.


RESULTS
Brain ischemia induced glucose intolerance in both rat strains. Basal glycemia was significantly increased by the brain ischemia in male and female Wistar rats, but not in Koletsky rats. The analysis of the effect of Terguride treatment of glucose abnormalities on the "area under the glucose tolerance curve" (AUC) has shown significant decrease of AUC in both sexes of Wistar strain and in females of Koletsky strain. Basal glycemia was significantly decreased only in males of Wistar strain.


CONCLUSIONS
Terguride (trans-dihydrolisuride) decreases hyperglycemia in rats with ischemic brain damage. (Fig. 4, Ref. 29.)
Kudlackova
Z
Z
Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University in Prague, Hradec Králové, Czech Republic. kudlacko@faf.cuni.cz
Golda
V
V
D000818:Animals; D019540:Area Under Curve; D002545:Brain Ischemia / Q000378:metabolism*; D018491:Dopamine Agonists / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D008090:Lisuride / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
D018491:Dopamine Agonists; C006208:dironyl; D008090:Lisuride; D005947:Glucose