EPIMHC: a curated database of MHC-binding peptides for customized computational vaccinology.
CONCLUSIONS
EPIMHC is a relational database of MHC-binding peptides and T cell epitopes that are observed in real proteins. Currently, the database contains 4867 distinct peptide sequences from various sources, including 84 tumor-associated antigens. The EPIMHC database is accessible through a web server that has been designed to facilitate research in computational vaccinology. Importantly, peptides resulting from a query can be selected to derive specific motif-matrices. Subsequently, these motif-matrices can be used in combination with a dynamic algorithm for predicting MHC-binding peptides from user-provided protein queries.


BACKGROUND
The EPIMHC database server is hosted by the Dana-Farber Cancer Institute at the site http://immunax.dfci.harvard.edu/bioinformatics/epimhc/
Reche
Pedro A
PA
Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. reche@research.dfci.harvard.edu
Zhang
Hong
H
Glutting
John-Paul
JP
Reinherz
Ellis L
EL
D003628:Database Management Systems; D030562:Databases, Protein; D015195:Drug Design; D018604:Epitope Mapping / Q000379:methods; D006680:HLA Antigens / Q000737:chemistry; D006649:Histocompatibility Antigens / Q000737:chemistry*; D016247:Information Storage and Retrieval / Q000379:methods; D008285:Major Histocompatibility Complex; D010455:Peptides / Q000737:chemistry*; D011485:Protein Binding; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D014584:User-Computer Interface; D014611:Vaccination
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D010455:Peptides