A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population.
Studies have shown a strong positive association between schizophrenia and G72/G30, demonstrated by both individual markers and haplotypes. A further functional study also supports the role of G72 in the etiology of schizophrenia. In this study, we have replicated these results of transmission/disequilibrium testing (TDT) and haplotype analysis in the Han Chinese population, showing P values of 0.0018 and 0.00007 for individual markers and haplotypes, respectively. Hence, our data supports the hypothesis that G72/G30 are important candidate genes for explaining schizophrenia in the Han Chinese population.
Zou
Fanggeng
F
Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai 200031, PR China.
Li
Chao
C
Duan
Shiwei
S
Zheng
Yonglan
Y
Gu
Niufan
N
Feng
Guoyin
G
Xing
Yangling
Y
Shi
Jianguo
J
He
Lin
L
D000328:Adult; D044466:Asian People / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002681:China; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D015810:Linkage Disequilibrium; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*
D002352:Carrier Proteins; C475071:DAOA protein, human; C488199:DAOAAS gene product, human; D005819:Genetic Markers; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D012333:RNA, Messenger