Decrease in circulating anti-angiogenic factors (angiostatin and endostatin) after surgical removal of primary colorectal carcinoma coincides with increased metabolic activity of liver metastases.
Removal of a primary colorectal tumor resulted in an increase in metabolic activity in its liver metastasis. Concomitantly, levels of angiostatin and endostatin in urine and plasma, respectively, dropped. This finding indicates that the primary tumor suppressed angiogenesis in its distant metastasis, and that removal of the primary lesion caused a flare-up in vessel neoformation and, thus, enhanced metabolic activity in its liver metastasis.
Peeters
Charlotte F J M
CF
Department of Pathology 437, University Medical Center, PO Box 9101, Nijmegen 6500 HB, The Netherlands. c.peeters@pathol.umcn.nl
de Geus
Lioe-Fee
LF
Westphal
Johan R
JR
de Waal
Robert M W
RM
Ruiter
Dirk J
DJ
Wobbes
Theo
T
Oyen
Wim J G
WJ
Ruers
Theo J
TJ
D000368:Aged; D043168:Angiostatins / Q000652:urine*; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000601:surgery*; D043169:Endostatins / Q000097:blood*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000556:secondary*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
D043169:Endostatins; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D043168:Angiostatins