DNA topoisomerase I inhibitors from Rinorea anguifera.
An organic extract prepared from Rinorea anguifera was investigated in order to identify the natural principle(s) responsible for stabilization of a topoisomerase I-DNA covalent binary complex. Bioassay-guided fractionation resulted in the isolation of mauritianin and (+)-syringaresinol as new topoisomerase I inhibitors, and also of the known inhibitor camptothecin.
Ma
Ji
J
Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, VA 22901, USA.
Jones
Shannon H
SH
Marshall
Rebekah
R
Wu
Xihan
X
Hecht
Sidney M
SM
D002166:Camptothecin / Q000302:isolation & purification; D004247:DNA / Q000378:metabolism; D004264:DNA Topoisomerases, Type I / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000302:isolation & purification*; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D044949:Kaempferols / Q000302:isolation & purification / Q000494:pharmacology; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
D004791:Enzyme Inhibitors; D005663:Furans; D044949:Kaempferols; D017705:Lignans; D010936:Plant Extracts; D059004:Topoisomerase I Inhibitors; C069907:mauritianin; C042192:syringaresinol; D004247:DNA; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin