title: Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the larynx.
abstract: BACKGROUND
  Mucosa-associated lymphoid tissue (MALT) lymphoma is usually associated with a chronic inflammatory disease from which lymphoid tissue of MALT type arises as a prerequisite for lymphoma proliferation. No well-characterized chronic inflammatory process has been identified in the larynx.
  
  
  METHODS
  We report a case of primary MALT lymphoma of the larynx associated with extraesophageal reflux, chronic laryngitis, and gastric Helicobacter pylori infection, raising the issue of its physiopathology and treatment.
  
  
  RESULTS
  Treatment of this MALT lymphoma of the larynx consisted of complete surgical excision associated with omeprazole, amoxicillin, and clarithromycin. No evidence of disease was observed after 24 months of follow-up.
  
  
  CONCLUSIONS
  We may assume that chronic laryngitis could be a precursor to MALT lymphoma. This case is the first one to our knowledge of a primary MALT lymphoma of the larynx treated with conservative management combining surgical excision, reflux therapy, and eradication of gastric H. pylori infection.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Hôpital Européen Georges Pompidou, 20, rue Leblanc, 75015 Paris, France.
authors.forename: Romain E
authors.initials: RE
authors.lastname: Kania
authors.forename: Dana M
authors.initials: DM
authors.lastname: Hartl
authors.forename: Cécile
authors.initials: C
authors.lastname: Badoual
authors.forename: Christine
authors.initials: C
authors.lastname: Le Maignan
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Brasnu
mesh_terms: D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery