title: Assessment of global and regional left ventricular function by electrocardiographic gated N-13 ammonia positron emission tomography in patients with coronary artery disease.
abstract: BACKGROUND
  Electrocardiographic gated 13N-ammonia positron emission tomography (PET) enables simultaneous assessment of myocardial blood flow and left ventricular (LV) function. The aim of this study was to assess the accuracy of gated 13N-ammonia PET for evaluating global and regional LV function in patients with coronary artery disease (CAD) in comparison with conventional left ventriculography (LVG).
  
  
  RESULTS
  Fifty-four patients with CAD underwent gated 13N-ammonia PET and LVG. The LV end-diastolic and end-systolic volumes (LVEDV, LVESV) and ejection fraction (LVEF) by gated 13N-ammonia PET were calculated using Cedars-Sinai automated quantitative gated single photon emission computed tomography (QGS) and compared with those obtained by LVG. The regional wall motion (RWM) was visually scored, and compared with that on LVG. There were good correlations between the 2 methods for LVEF, LVEDV and LVESV (R=0.828, R=0.821 and R=0.874 respectively). The RWM assessed by gated 13N-ammonia PET also agreed well with that by LVG (complete agreement was 70.4%, kappa=0.58).
  
  
  CONCLUSIONS
  Gated 13N-ammonia PET combined with QGS works reasonably well for the assessment of both global and regional LV function in CAD patients, although additional calibration may be necessary.
authors.affiliation: Department of Cardiology, Kanazawa Medical University, Ishikawa, Japan. sugako-k@kanazawa-med.ac.jp
authors.forename: Sugako
authors.initials: S
authors.lastname: Kanayama
authors.forename: Ichiro
authors.initials: I
authors.lastname: Matsunari
authors.forename: Akira
authors.initials: A
authors.lastname: Hirayama
authors.forename: Michihiko
authors.initials: M
authors.lastname: Kitayama
authors.forename: Masamichi
authors.initials: M
authors.lastname: Matsudaira
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yoneyama
authors.forename: Stephan G
authors.initials: SG
authors.lastname: Nekolla
authors.forename: Kinichi
authors.initials: K
authors.lastname: Hisada
authors.forename: Koji
authors.initials: K
authors.lastname: Kajinami
authors.forename: Noboru
authors.initials: N
authors.lastname: Takekoshi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000641:Ammonia; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003326:Coronary Circulation; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D009590:Nitrogen Radioisotopes; D049268:Positron-Emission Tomography / Q000379:methods*; D015635:Radionuclide Ventriculography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*; D016277:Ventricular Function, Left
chemical_list: D009590:Nitrogen Radioisotopes; D000641:Ammonia