title: Plasmonics-based nanostructures for surface-enhanced Raman scattering bioanalysis.
abstract: Surface-enhanced Raman scattering (SERS) spectroscopy is a plasmonics-based spectroscopic technique that combines modern laser spectroscopy with unique optical properties of metallic nanostructures, resulting in strongly increased Raman signals when molecules are adsorbed on or near nanometer-size structures of special metals such as gold, silver, and transition metals. This chapter provides a synopsis of the development and application of SERS-active metallic nanostructures, especially for the analysis of biologically relevant compounds. Some highlights of this chapter include reports of SERS as an immunoassay readout method, SERS gene nanoprobes, near-field scanning optical microscopy SERS probes, SERS as a tool for single-molecule detection, and SERS nanoprobes for cellular studies.
authors.affiliation: Center for Advanced Biomedical Photonics, Life Sciences Division, Oak Ridge National Laboratory, TN, USA.
authors.forename: Tuan
authors.initials: T
authors.lastname: Vo-Dinh
authors.forename: Fei
authors.initials: F
authors.lastname: Yan
authors.forename: David L
authors.initials: DL
authors.lastname: Stokes
mesh_terms: D004247:DNA / Q000032:analysis; D015342:DNA Probes; D007118:Immunoassay / Q000379:methods; D049329:Nanostructures; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods
chemical_list: D015342:DNA Probes; D004247:DNA