title: Use of a prediction model for high-order multiple implantation after ovarian stimulation with gonadotropins.
abstract: OBJECTIVE
  To determine prospectively the effectiveness in clinical practice of a prediction model for high-order multiple pregnancies (HOMP) (triplets or more).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Eight hundred forty-nine consecutive infertile patients undergoing a total of 1,542 treatment cycles.
  
  
  METHODS
  Gonadotropin ovarian stimulation or induction of ovulation without IVF MAIN OUTCOME MEASURE(S): Observed and predicted overall pregnancy rates and the incidence of HOMP.
  
  
  RESULTS
  The use of the prediction model (implying cancellation of all cycles at high risk for HOMP) would result in an 8% (95% confidence interval, 6.8%-9.2%) reduction of overall pregnancy rate but also in a 285% (95% CI, 279%-291%) reduction of HOMP.
  
  
  CONCLUSIONS
  By using our prediction model, it was possible to maintain a low risk of HOMP with a good pregnancy rate in patients receiving gonadotropin ovarian stimulation or induction of ovulation without IVF.
authors.affiliation: Reproductive Medicine Service, Department of Obstetrics and Gynaecology, Institut Universitari Dexeus, Barcelona, Spain. rostur@dexeus.com
authors.forename: Rosa
authors.initials: R
authors.lastname: Tur
authors.forename: Pedro N
authors.initials: PN
authors.lastname: Barri
authors.forename: Buenaventura
authors.initials: B
authors.lastname: Coroleu
authors.forename: Rosario
authors.initials: R
authors.lastname: Buxaderas
authors.forename: Núria
authors.initials: N
authors.lastname: Parera
authors.forename: Juan
authors.initials: J
authors.lastname: Balasch
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D010064:Embryo Implantation; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D010062:Ovulation Induction; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011446:Prospective Studies
chemical_list: D006063:Chorionic Gonadotropin; D004958:Estradiol