title: In vitro genotoxic and cytotoxic effects of protein somatic products from helminths on donor blood lymphocytes.
abstract: Protein somatic products of adult helminths Hymenolepis nana and Toxocara canis and secretory-excretory somatic product of Trichinella spiralis larvae in vitro produced genotoxic and cytotoxic effects on donor blood lymphocytes, which manifested in accumulation of single-chain breaks, alkaline-labile sites in nuclear DNA, and apoptotic cells. This effect depended on the concentration of parasitic protein products during coculturing.
authors.affiliation: Department of Medical Biology and General Genetics, Vitebsk State Medical University, Moscow. bekishvl@tut.by
authors.forename: Vl Ya
authors.initials: VY
authors.lastname: Bekish
authors.forename: A D
authors.initials: AD
authors.lastname: Durnev
mesh_terms: D000328:Adult; D000818:Animals; D001782:Blood Donors; D020552:Comet Assay; D004249:DNA Damage; D005260:Female; D015801:Helminth Proteins / Q000633:toxicity*; D006801:Humans; D048189:Hymenolepis nana / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D017166:Toxocara canis / Q000378:metabolism*; D017160:Trichinella spiralis / Q000378:metabolism*
chemical_list: D015801:Helminth Proteins