title: Corneal oxygen deficiency.
abstract: OBJECTIVE
  To compare the ocular effects of low Dk hydrogel and high Dk silicone hydrogel contact lenses.
  
  
  METHODS
  A review of recent literature was conducted to determine the effects of wearing low and high Dk soft lenses on corneal swelling, vascular response, refractive error and the corneal epithelium.
  
  
  RESULTS
  High Dk silicone hydrogel contact lenses became available for research and clinical practice almost 10 and 5 years ago respectively. During that time many studies have been conducted and it has been demonstrated repeatedly how much improvement there has been to the physiological response of the eye particularly when wearing the lenses on an overnight basis.
  
  
  CONCLUSIONS
  Although silicone hydrogels only constitute about 2% of current wearers, their positive effects on the eye compared with low Dk hydrogel lenses should make them the most dominant lenses in the near future.
authors.affiliation: Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada. dfonn@sciborg.uwaterloo.ca
authors.forename: Desmond
authors.initials: D
authors.lastname: Fonn
authors.forename: Deborah
authors.initials: D
authors.lastname: Sweeney
authors.forename: Brien A
authors.initials: BA
authors.lastname: Holden
authors.forename: Dwight
authors.initials: D
authors.lastname: Cavanagh
mesh_terms: D001424:Bacterial Infections / Q000209:etiology; D003261:Contact Lenses / Q000009:adverse effects*; D003315:Cornea / Q000382:microbiology; D003316:Corneal Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D000860:Hypoxia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012828:Silicones
chemical_list: D012828:Silicones; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate