Alternative medical treatment strategies for chronic hyperplastic eosinophilic sinusitis.
OBJECTIVE
Chronic rhinosinusitis (CRS) is one of the most common chronic illnesses in the United States. Although CRS has been viewed traditionally as an infectious disease, treatment focused on antibiotics and surgery has not infrequently provided disappointing results.


RESULTS
Recently much of CRS has been shown to be an eosinophilic inflammatory disease and new anti-inflammatory treatments are being studied.


CONCLUSIONS
This review discusses medical management for chronic hyperplastic eosinophilic sinusitis, including antifungal treatment, low-dose macrolide treatment, antilipid mediator therapy, and new immune-modifying treatments.
Amrol
David
D
Division of Allergy and Immunology, Department of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Murray
John J
JJ
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D002908:Chronic Disease; D004802:Eosinophilia / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods*; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D009181:Mycoses / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D020024:Leukotriene Antagonists; D001241:Aspirin