title: Energy biogenesis: one key for coordinating two genomes.
abstract: In metazoan organisms, energy production is the only example of a process that is under dual genetic control: nuclear and mitochondrial. We used a genomic approach to examine how energy genes of both the nuclear and mitochondrial genomes are coordinated, and discovered a novel genetic regulatory circuit in Drosophila melanogaster that is surprisingly simple and parsimonious. This circuit is based on a single DNA regulatory element and can explain both intra- and inter-genomic coordinated expression of genes involved in energy production, including the full complement of mitochondrial and nuclear oxidative phosphorylation genes, and the genes involved in the Krebs cycle.
authors.affiliation: Dipartimento di Anatomia Patologica e di Genetica, Sezione di Genetica, Università di Bari, via Amendola 165/A, 70126 Bari, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Sardiello
authors.forename: Gaetano
authors.initials: G
authors.lastname: Tripoli
authors.forename: Antonio
authors.initials: A
authors.lastname: Romito
authors.forename: Crescenzio
authors.initials: C
authors.lastname: Minervini
authors.forename: Luigi
authors.initials: L
authors.lastname: Viggiano
authors.forename: Corrado
authors.initials: C
authors.lastname: Caggese
authors.forename: Graziano
authors.initials: G
authors.lastname: Pesole
mesh_terms: D000818:Animals; D000852:Anopheles / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics*; D004734:Energy Metabolism / Q000235:genetics*; D016678:Genome
chemical_list: D004272:DNA, Mitochondrial