title: Comparison of gene expression in intra-abdominal and subcutaneous fat: a study of men with morbid obesity and nonobese men using microarray and proteomics.
abstract: Extent of intra-abdominal fat had significant linear relations with six metabolic coronary risk factors: systolic and diastolic blood pressure, fasting blood concentrations of glucose, high density lipoprotein (HDL) cholesterol, triglyceride, and plasminogen activator inhibitor-1. Tumor necrosis factor-alpha and adiponectin can be biological mediators from the intra-abdominal fat to the metabolic coronary risk factors. Complementarily, we describe a new study that will analyze the gene expression in intra-abdominal and subcutaneous fat on mRNA and protein level using high throughput methods. The study will elucidate further whether intra-abdominal obesity is the common denominator for the different components of the metabolic syndrome.
authors.affiliation: Center of Tobacco Control Research, Birkevej 17, 5230 Odense M, Denmark. finnvon@mail.tele.dk
authors.forename: Finn Edler
authors.initials: FE
authors.lastname: von Eyben
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Kroustrup
authors.forename: Jens Fromholt
authors.initials: JF
authors.lastname: Larsen
authors.forename: Julio
authors.initials: J
authors.lastname: Celis
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000235:genetics* / Q000601:surgery; D020411:Oligonucleotide Array Sequence Analysis; D040901:Proteomics