title: Reproducibility of gastric tone, compliance and gastric accommodation assessed with barostat in conscious dogs.
abstract: The reproducibility of barostat measurements was unclear. In this study, the intraday and interday reproducibility of barostat measurements of gastric tone, compliance and gastric accommodation were assessed in a canine model. A series of experiments were performed using a barostat system in 11 surgically prepared healthy dogs: (i) interday gastric tone and compliance: three sessions on three separate days; (ii) intraday gastric tone and compliance: two sessions on the same day separated by a 30-min interval; (iii) interday gastric accommodation: two sessions on two separate days, with each including a 30-min baseline and a 60-min postprandial period. The results were (i) interday gastric tone (81.2 +/- 7.5 mL vs 89.2 +/- 8.1 mL vs 86.2 +/- 13.6 mL, n = 11) and compliance (n = 8) were comparable; (ii) intraday gastric tone (87.9 +/- 17.2 mL vs 77.0 +/-14.8 mL, n = 8) and compliance (n = 8) was also similar, but with considerable individual variance; (iii) interday gastric accommodation was 320.8 +/-45.1 mL vs 287.9 +/- 31.2 mL, no significant difference (n = 8). Inter- and intraday gastric tone and compliance and interday gastric accommodation were relatively reproducible in most animals when tested under well-controlled conditions. However, considerable variations may occur in fasting gastric tone and compliance measurements in certain individuals and cautions should be given when interpreting related results.
authors.affiliation: Transneuronix Inc., Oklahoma City, OK, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Xing
authors.forename: J D Z
authors.initials: JD
authors.lastname: Chen
mesh_terms: D000818:Animals; D002404:Catheterization; D003187:Compliance; D004285:Dogs; D005260:Female; D008365:Manometry / Q000379:methods*; D009129:Muscle Tonus / Q000502:physiology*; D015203:Reproducibility of Results; D013270:Stomach / Q000502:physiology*