title: A simple method for predicting imaging-based complications following gamma knife surgery for cerebral arteriovenous malformations.
abstract: OBJECTIVE
  The authors studied the relationship between dose planning parameters and complications in the treatment of cerebral arteriovenous malformations (AVMs).
  
  
  METHODS
  There were 41 continuous unselected patients. The mean follow-up period was 19 months; the mean age was 28 years; the male/female ratio was 2.2:1.0; the median prescription dose was 25 Gy (range 14-25 Gy); the median prescription isodose was 50%. The median lesion volume was 4.4 cm3. The median lesion coverage was 93%; and the mean conformity index was 1.22. The authors found no relationship between lesion volume or integral dose and the development of the clinical effects based on the adverse radiation effects (AREs); however, there was a significant relationship between both target volume and integral dose with the development of AREs as well as the severity of the AREs.
  
  
  CONCLUSIONS
  The integral dose could be used as a guideline for the prescription dose. Arguments are made for maximizing the prescription dose for the long-term safety of the patient.
authors.affiliation: Gamma Knife Center, Cairo, Egypt. jcganz@link.net
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Ganz
authors.forename: Wael A
authors.initials: WA
authors.lastname: Reda
authors.forename: Khalid
authors.initials: K
authors.lastname: Abdelkarim
authors.forename: Ayman
authors.initials: A
authors.lastname: Hafez
mesh_terms: D000293:Adolescent; D000328:Adult; D001929:Brain Edema / Q000209:etiology* / Q000473:pathology*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D016634:Radiosurgery / Q000009:adverse effects* / Q000295:instrumentation*