Admixture mapping for hypertension loci with genome-scan markers.
Identification of genetic variants that contribute to risk of hypertension is challenging. As a complement to linkage and candidate gene association studies, we carried out admixture mapping using genome-scan microsatellite markers among the African American participants in the US National Heart, Lung, and Blood Institute's Family Blood Pressure Program. This population was assumed to have experienced recent admixture from ancestral groups originating in Africa and Europe. We used a set of unrelated individuals from Nigeria to represent the African ancestral population and used the European Americans in the Family Blood Pressure Program to provide estimates of allele frequencies for the European ancestors. We genotyped a common set of 269 microsatellite markers in the three groups at the same laboratory. The distribution of marker location-specific African ancestry, based on multipoint analysis, was shifted upward in hypertensive cases versus normotensive controls, consistent with linkage to genes conferring susceptibility. This shift was largely due to a small number of loci, including five adjacent markers on chromosome 6q and two on chromosome 21q. These results suggest that chromosome 6q24 and 21q21 may contain genes influencing risk of hypertension in African Americans.
Zhu
Xiaofeng
X
Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, 2160 S. First Ave., Maywood, Illinois 60153, USA.
Luke
Amy
A
Cooper
Richard S
RS
Quertermous
Tom
T
Hanis
Craig
C
Mosley
Tom
T
Gu
C Charles
CC
Tang
Hua
H
Rao
Dabeeru C
DC
Risch
Neil
N
Weder
Alan
A
D044383:Black People; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D002896:Chromosomes, Human, Pair 6; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D018895:Microsatellite Repeats; D009549:Nigeria; D011110:Polymorphism, Genetic; D001741:Black or African American