IL-18 and antigen-specific CD4(+) regulatory T cells in Peyer's patches.
A study using gene-deficient mice revealed that IL-18 is essential for inducing antigen-specific regulatory T cells and oral tolerance. It is also suggested that IL-18 is a functional downregulator for immunogenic dendritic cells, contributing to the maintenance of homeostasis for intestinal immunity.
Tsuji
Noriko M
NM
Department of Molecular Biology and Immunology, National Institute of Agrobiological Sciences, 2-1-2 Kannondai, Tsukuba, Ibaraki 305-8602, Japan. ten@affrc.go
Nowak
Bernadeta
B
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D007108:Immune Tolerance; D020382:Interleukin-18 / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D007782:Lactoglobulins / Q000008:administration & dosage / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009061:Mouth Mucosa / Q000276:immunology; D010581:Peyer's Patches / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D020382:Interleukin-18; D007782:Lactoglobulins