Pseudo-peptides derived from isomannide as potential inhibitors of serine proteases.
Hepatitis C, Dengue and West Nile virus are among of the most important flaviviruses that share one important serine protease enzyme. Serine proteases belong to the most studied class of proteolytic enzymes, and are a primary target in the drug development field. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N-t-Boc amino acid amides derived of isomannide as potential serine proteases inhibitors.
Muri
E M F
EM
Instituto de Química, Universidade do Brasil, Cidade Universitária, CT Bloco A, Rio de Janeiro, Brasil.
Gomes
M
M
Albuquerque
M G
MG
da Cunha
E F F
EF
de Alencastro
R B
RB
Williamson
J S
JS
Antunes
O A C
OA
D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D018067:Flaviviridae / Q000201:enzymology*; D018178:Flaviviridae Infections / Q000188:drug therapy; D006801:Humans; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D012697:Serine Endopeptidases / Q000737:chemistry*; D015842:Serine Proteinase Inhibitors / Q000737:chemistry*; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry*
C502182:1,4-3,6-dianhydromannitol; D019086:Bridged Bicyclo Compounds, Heterocyclic; D010455:Peptides; D015842:Serine Proteinase Inhibitors; D014764:Viral Proteins; D012697:Serine Endopeptidases