title: Agranulocytosis associated with parvovirus B19 infection in otherwise healthy patients.
abstract: In the course of 6 years, 23 otherwise healthy patients with acute febrile illness and leukopenia were diagnosed as having acute parvovirus B19 infection. Five of these patients had agranulocytosis associated with acute parvovirus B19 infection and one had chronic agranulocytosis due to persistent parvovirus B19 infection. The diagnosis was made after positive anti-parvovirus B19 IgM antibodies were found in all of the patients and viral DNA was detected by PCR in four patients. Neutropenia and agranulocytosis appear to be much more frequently associated with parvovirus B19 infection than previously reported.
authors.affiliation: Department of Internal Medicine C, Hillel Yaffe Medical Center, Hadera, Israel.
authors.forename: Valery
authors.initials: V
authors.lastname: Istomin
authors.forename: Ester
authors.initials: E
authors.lastname: Sade
authors.forename: Zahava
authors.initials: Z
authors.lastname: Grossman
authors.forename: Hagit
authors.initials: H
authors.lastname: Rudich
authors.forename: Orit
authors.initials: O
authors.lastname: Sofer
authors.forename: David
authors.initials: D
authors.lastname: Hassin