title: Microwave coagulation therapy in canine peripheral lung tissue.
abstract: BACKGROUND
  New modalities for local treatments that destroy tumor effectively but which are less invasive and less damaging to normal lung tissue must be developed for patients who are unable to undergo even video-assisted thoracic surgery (VATS) due to poor cardiopulmonary function, severe adhesion, or advanced age, etc. We evaluated the use of microwave coagulation therapy (MCT), which has been used successfully for coagulation of hepatic tumors, in normal canine lung tissue to evaluate its efficacy and safety.
  
  
  METHODS
  Measurements of thermal response and coagulation area and histological examinations after microwave coagulation were performed in normal canine lung tissue.
  
  
  RESULTS
  The temperature in normal canine lung tissue increased to 90-100 degrees C at 5 mm from the electrode after 60 s and 70-80 degrees C at 10 mm after 90 s at 40 or 60 W. The coagulation area was approximately 20 mm in diameter at 40 W and 60 W. Histological analysis demonstrated thickening of collagen fiber shortly after coagulation, stromal edema and granulation tissue after 3 months, and, finally, scar tissue was seen after 6 months.
  
  
  CONCLUSIONS
  Microwave coagulation therapy (MCT) is a useful modality for minimally invasive therapy in peripheral lung tumors.
authors.affiliation: Department of Thoracic Surgery, Kasumigaura Hospital, Tokyo Medical University, 3-20-1 Chuo Ami-machi, Inashiki-gun, Ibaraki 300-0395, Japan. k-furu@tokyo-med.ac.jp
authors.forename: Kinya
authors.initials: K
authors.lastname: Furukawa
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Miura
authors.forename: Yasuhumi
authors.initials: Y
authors.lastname: Kato
authors.forename: Shinya
authors.initials: S
authors.lastname: Okada
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Tsutsui
authors.forename: Hideaki
authors.initials: H
authors.lastname: Shimatani
authors.forename: Naohiro
authors.initials: N
authors.lastname: Kajiwara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Taira
authors.forename: Makoto
authors.initials: M
authors.lastname: Saito
authors.forename: Harubumi
authors.initials: H
authors.lastname: Kato
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D004285:Dogs; D004487:Edema; D004564:Electrocoagulation / Q000379:methods*; D006097:Granulation Tissue; D006979:Hyperthermia, Induced / Q000379:methods; D008168:Lung / Q000378:metabolism / Q000473:pathology* / Q000528:radiation effects*; D008872:Microwaves; D023421:Models, Animal
chemical_list: D003094:Collagen