Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay.
Intestinal injury that results from chemotherapy belongs to the major factors of dose-limitation in tumour therapy. The tyrphostins AG1714 and AG1801 reduce cisplatin and 5-FU-induced small intestinal mucosal damage, using a quantitative biochemical assay. The assay is based on the determination of the enzymatic activity of gamma-glutamyl transpeptidase, a marker of the brush border epithelium of the small intestine.
Zlotnik
Y
Y
Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Rabin Medical Center, Beilinson Campus, Petah-Tikva 49100, Israel.
Patya
M
M
Vanichkin
A
A
Novogrodsky
A
A
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects; D007410:Intestinal Diseases / Q000139:chemically induced / Q000517:prevention & control*; D007413:Intestinal Mucosa / Q000187:drug effects*; D051379:Mice; D020032:Tyrphostins / Q000627:therapeutic use*; D005723:gamma-Glutamyltransferase / Q000187:drug effects
D000970:Antineoplastic Agents; D020032:Tyrphostins; D005723:gamma-Glutamyltransferase; D002945:Cisplatin; D005472:Fluorouracil