HLA B-27 subtypes in Turkish patients with spondyloarthropathy and healthy controls.
The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B*27 was 2.6% in the Turkish population, and B*2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B*2705 among B27-positive patients and controls was significantly different (P=0.02). Our study supports other reports from different populations which showed that B*2705 and B*2702 were more frequent in Caucasian patients with SpA.
Oguz
Fatma Savran
FS
Istanbul University, Istanbul Medical Faculty, Department of Medical Biology Istanbul, Turkey. oguzsf@usa.net
Ocal
Lale
L
Diler
Ali Sarper
AS
Ozkul
Hilmi
H
Asicioglu
Faruk
F
Kasapoglu
Esen
E
Bozkurt
Gokay
G
Konice
Meral
M
Carin
Mahmut
M
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004247:DNA / Q000378:metabolism; D005260:Female; D005838:Genotype; D015796:HLA-B27 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018807:Polymorphism, Single-Stranded Conformational; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D014421:Turkey
D015796:HLA-B27 Antigen; D004247:DNA