title: Diagnostic value of a peroral sucrose permeability test in children with recurrent upper abdominal pain.
abstract: The access of ingested sucrose into blood and urine indicates the presence of mucosal lesions in the upper gastrointestinal tract. The study involved 42 children, aged 5-15, having recurrent upper abdominal pain and 43 peers with minor extra-abdominal complaints. Sucrose in urine was determined by thin layer chromatography. The test was positive in 27 out of 42 children having recurrent abdominal pain (64.3%) and in none of the control children (chi2 = 37.6, p < 0.0001). When correlated with endoscopic findings it was falsely negative in 12 out of 38 patients with endoscopically verified lesions of the stomach or duodenum and falsely positive in 1 out of 4 without lesions. Sensitivity of the test was 68.4%, specificity 97.9%, positive predictive value 96.3%. The test cannot be used as an alternative to endoscopy, but may serve for screening of candidates for it.
authors.affiliation: Department of Pediatrics, Clinical Hospital Osijek, Croatia. ljerka.pinotic@os.htnet.hr
authors.forename: Ljerka
authors.initials: L
authors.lastname: Pinotić
authors.forename: Mirjana
authors.initials: M
authors.lastname: Zecić-Fijacko
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Vcev
authors.forename: Dubravko
authors.initials: D
authors.lastname: Paulini
authors.forename: Silvije
authors.initials: S
authors.lastname: Mihaljević
authors.forename: Darko
authors.initials: D
authors.lastname: Horvat
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Mandić
authors.forename: Ana
authors.initials: A
authors.lastname: Votava-Raić
authors.forename: Milivoj
authors.initials: M
authors.lastname: Boranić
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016099:Endoscopy, Gastrointestinal; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008297:Male; D010539:Permeability; D011237:Predictive Value of Tests; D012008:Recurrence; D012680:Sensitivity and Specificity; D013395:Sucrose / Q000008:administration & dosage / Q000652:urine*; D013549:Sweetening Agents / Q000008:administration & dosage / Q000032:analysis*
chemical_list: D013549:Sweetening Agents; D013395:Sucrose