The spanish connection: transcription and mRNA processing get even closer.
The synthesis of mRNA by RNA polymerase II appears coupled to numerous RNA-processing events, based on physical or functional connections revealed by biochemical or genetic tests. New findings were presented at a recent meeting in Spain that begin to illuminate the mechanisms underlying the connections between mRNA processing and specific steps in transcription (initiation, elongation, and termination) as well as recombination.
Ares
Manuel
M
Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA. ares@biology.ucsc.edu
Proudfoot
Nick J
NJ
D005057:Eukaryotic Cells / Q000378:metabolism; D009690:Nucleic Acid Conformation; D012319:RNA Polymerase II / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology*; D012326:RNA Splicing / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D013030:Spain; D014158:Transcription, Genetic; D039221:mRNA Cleavage and Polyadenylation Factors / Q000378:metabolism
D012333:RNA, Messenger; D039221:mRNA Cleavage and Polyadenylation Factors; D012319:RNA Polymerase II