Diabetic mastopathy in type II diabetes mellitus.
Diabetic mastopathy can mimic cancer. We report 2 cases of diabetic mastopathy in patients with long-standing type II diabetes. One was insulin-dependent, and the other had never been treated with insulin. These 2 patients had classical acoustical shadow on ultrasonograms. Breast core biopsies showed constellations of morphological features resembling diabetic mastopathy, including sclerotic changes of the fibrous stroma with keloid-like collagen fibers, few epithelioid fibroblasts, perivascular and interlobular mononuclear cell infiltrates, and focal atrophic changes of the ductal-lobular units. Both patients were free of malignancy at 3 and 4 years of follow-up, respectively. There are limited data on diabetic mastopathy in insulin-naive type II diabetes mellitus patients. Better awareness of this entity and its sonographic features may allow more patients to be spared from excisional biopsy.
Tsung
Jeffrey S H
JS
Department of Pathology, Sun Yat-Sen Cancer Center, Taipei, Taiwan.
Wang
Teh Y
TY
Lin
Christopher K Z
CK
D000368:Aged; D001706:Biopsy; D001940:Breast / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged