Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues.
The synthesis and the biological evaluation (acetylcholinesterase inhibition activity and neuroprotection) of the new tacrine analogues 2-14 is described.
León
Rafael
R
Laboratorio de Radicales Libres (IQOG, CSIC), C/ Juan de la Cierva 3, 28006 Madrid, Spain.
Marco-Contelles
José
J
García
Antonio G
AG
Villarroya
Mercedes
M
D000818:Animals; D002417:Cattle; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D019439:Chromaffin Cells / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013619:Tacrine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D018696:Neuroprotective Agents; D013619:Tacrine