Synthesis of a peptidocalix[4]arene library and identification of compounds with hydrolytic activity.
A 120 member library of peptidocalix[4]arenes was synthesized and screened for catalysis of the hydrolysis of p-nitrophenyl acetate. His-Ser-His-calix[4]arene was found to catalyze this reaction with v(0)=3.24 x 10(-8)M/s, an increase of 1520% above background and 30% above the tripeptide (His-Ser-His) alone.
Brewster
R Elizabeth
RE
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30329-0400, USA.
Dalton
Brian G A
BG
Shuker
Suzanne Beckham
SB
D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000494:pharmacology; D047250:Calixarenes / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D006868:Hydrolysis; D008956:Models, Chemical; D009596:Nitrophenols / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology; D013997:Time Factors
D001952:Bridged-Ring Compounds; D009596:Nitrophenols; D009842:Oligopeptides; D010636:Phenols; C121325:calix(4)arene; C500594:histidyl-seryl-histidylcalix(4)arene; D047250:Calixarenes; C008642:4-nitrophenyl acetate