The use of levonorgestrel-releasing intrauterine system for treatment of menorrhagia in women with inherited bleeding disorders.
BACKGROUND
The levonorgestrel-releasing intrauterine system (LNG-IUS) is used commonly by gynaecologists as a contraceptive and to treat menorrhagia. However, its efficacy has not been examined in women with inherited bleeding disorders.


METHODS
A prospective pilot study.


METHODS
A teaching hospital in north London with a designated haemophilia centre.


METHODS
Female patients with a known inherited bleeding disorder.


METHODS
Sixteen women with subjective and objective menorrhagia caused by inherited bleeding disorders (13 von Willebrand's Disease, two factor XI deficiency and one Hermansky-Pudlak syndrome), who had previously undergone unsuccessful medical treatment were followed up for nine months after LNG-IUS insertion. Bleeding was measured by pictorial chart and haemoglobin concentration.


RESULTS
All women reported that their periods were improved, pictorial chart scores were lower and 56% became amenorrhoeic. None reported side effects.


CONCLUSIONS
The LNG-IUS is well tolerated and effective and improves quality of life.
Kingman
C E C
CE
Department of Obstetrics and Gynaecology, Royal Free Hospital, London, UK.
Kadir
R A
RA
Lee
C A
CA
Economides
D L
DL
D000293:Adolescent; D000328:Adult; D025861:Blood Coagulation Disorders, Inherited / Q000150:complications*; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel / Q000008:administration & dosage*; D008595:Menorrhagia / Q000188:drug therapy* / Q000235:genetics; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies
D003271:Contraceptive Agents, Female; D016912:Levonorgestrel