Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury.
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. The PPAR subfamily comprises of three members, PPAR-alpha, PPAR-beta and PPAR-gamma. PPAR-gamma has recently been implicated as a regulator of cellular proliferation and inflammatory responses. There is good evidence that ligands of PPAR-gamma, including certain thiazolinediones, reduce tissue injury associated with ischemia and reperfusion. The potential utility of PPAR-gamma ligands in ischemia and reperfusion will be discussed in this review.
Cuzzocrea
Salvatore
S
Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, via C. Valeria, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy. salvator@unime.it
D000818:Animals; D006801:Humans; D007410:Intestinal Diseases / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism; D008024:Ligands; D008171:Lung Diseases / Q000378:metabolism; D009203:Myocardial Infarction / Q000378:metabolism; D009336:Necrosis / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism*; D015427:Reperfusion Injury / Q000378:metabolism*
D008024:Ligands; D047495:PPAR gamma