Extrapontine myelinolysis in infancy: report of a case.
Osmotic myelinolysis is a rare, acute, demyelinating process that involves the pons (central pontine myelinolysis) and other locations of the central nervous system (extrapontine myelinolysis). Central pontine myelinolysis is described in children, usually associated with rapid correction of hyponatremia. Other conditions, such as hypernatremia and hyperglycemia, have also been reported as being responsible for pontine myelinolysis. Extrapontine myelinolysis in childhood is very rare and presents in a wide variety of locations. We report a patient who developed extrapontine myelinolysis in the cerebellum during treatment of hyponatremic dehydration. This is the first case reported during infancy.
Haspolat
Senay
S
Department of Pediatric Neurology, Akdeniz University, Medical School, Antalya, Turkey. shaspolat@akdeniz.edu.tr
Duman
Ozgur
O
Senol
Utku
U
Yegin
Olcay
O
D001929:Brain Edema / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D002531:Cerebellum / Q000187:drug effects / Q000473:pathology; D003681:Dehydration / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005759:Gastroenteritis / Q000150:complications; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D007223:Infant; D008297:Male; D017590:Myelinolysis, Central Pontine / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D009460:Neurologic Examination / Q000187:drug effects; D012075:Remission, Spontaneous; D012965:Sodium Chloride / Q000008:administration & dosage / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology
D012965:Sodium Chloride