The role of leukocyte-stromal interactions in chronic inflammatory joint disease.
Rheumatoid arthritis (RA) is a debilitating, chronic, persistent inflammatory disease that is characterised by painful and swollen joints. The aetiology of RA is unknown, however whereas past research has concentrated on the role of immune or inflammatory infiltrating cells in inflammation, it is becoming clear that stromal cells play a critical part in regulating the quality and duration of an inflammatory response. In this review we assess the role of fibroblasts within the inflamed synovium in modulating immune responses; in particular we examine the role of stromal cells in the switch from resolving to persistent inflammation as is found in the rheumatoid synovium.
Burman
Angela
A
Rheumatology Research Group, Institute for Biomedical Research, Division of Immunity and Infection, MRC Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK.
Haworth
Oliver
O
Bradfield
Paul
P
Parsonage
Greg
G
Filer
Andrew
A
Thomas
Andrew M C
AM
Amft
Nicole
N
Salmon
Mike
M
Buckley
Christopher D
CD
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology*; D002450:Cell Communication / Q000276:immunology*; D002908:Chronic Disease; D006801:Humans; D007962:Leukocytes / Q000166:cytology* / Q000276:immunology; D017154:Stromal Cells / Q000166:cytology*; D013585:Synovitis / Q000276:immunology / Q000473:pathology