title: Human coronavirus NL63 infection in Canada.
abstract: The isolation of human coronavirus NL63 (HCoV-NL63) in The Netherlands raised questions about its contribution to respiratory illness. In this study, a total of 525 respiratory specimens, collected in Canada primarily during the winter months of 2001-2002, were tested for HCoV-NL63; 19 tested positive for HCoV-NL63, demonstrating virus activity during January-March 2002. Patients with HCoV-NL63 were 1 month-100 years old (median age, 37 years). The main clinical presentations were fever (15/19), sore throat (5/19), and cough (9/19), and 4 patients were hospitalized. These results provide evidence for the worldwide distribution of HCoV-NL63.
authors.affiliation: National Microbiology Laboratory, Canadian Science Center for Human and Animal Health, Winnipeg, Manitoba, Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bastien
authors.forename: Kelly
authors.initials: K
authors.lastname: Anderson
authors.forename: Laura
authors.initials: L
authors.lastname: Hart
authors.forename: Paul
authors.initials: P
authors.lastname: Van Caeseele
authors.forename: Ken
authors.initials: K
authors.lastname: Brandt
authors.forename: Doug
authors.initials: D
authors.lastname: Milley
authors.forename: Todd
authors.initials: T
authors.lastname: Hatchette
authors.forename: Elise C
authors.initials: EC
authors.lastname: Weiss
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002170:Canada / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D017934:Coronavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D018352:Coronavirus Infections / Q000453:epidemiology / Q000821:virology*; D003371:Cough / Q000209:etiology; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification; D004279:DNA, Viral / Q000737:chemistry / Q000302:isolation & purification; D005334:Fever / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010612:Pharyngitis / Q000209:etiology; D010802:Phylogeny; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000821:virology*; D043262:Ribonuclease P / Q000235:genetics; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics
chemical_list: D018076:DNA, Complementary; D004279:DNA, Viral; D014764:Viral Proteins; D043262:Ribonuclease P