title: Tramadol concentrations in blood and in cerebrospinal fluid in a neonate.
abstract: Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood-brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.
authors.affiliation: Department of Paediatrics, University Hospital, Gasthuisberg, Herestraat, Leuven, Belgium. karel.allegaert@uz.kuleuven.ac.be
authors.forename: K
authors.initials: K
authors.lastname: Allegaert
authors.forename: J
authors.initials: J
authors.lastname: de Hoon
authors.forename: R
authors.initials: R
authors.lastname: Verbesselt
authors.forename: H
authors.initials: H
authors.lastname: Devlieger
authors.forename: D
authors.initials: D
authors.lastname: Tibboel
mesh_terms: D000701:Analgesics, Opioid / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D019635:Neurosurgical Procedures; D014147:Tramadol / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol