[A case of postoperative liver metastases from gastric cancer successfully treated with hepatic arterial infusion of paclitaxel].
A 69-year-old man underwent total gastrectomy for advanced gastric cancer in August 2001. After surgery, he was treated daily with UFT 300 mg. In October 2002, the tumor marker (CEA) increased in value, and CT revealed multiple liver metastases. Because there were no extrahepatic metastases, we attempted to use hepatic arterial injection chemotherapy. A reservoir was placed in the hepatic artery on November 12. Thereafter, intra-arterial injection of paclitaxel at 120 mg (80 mg/m2) was administered over one hour to the reservoir. This arterial injection chemotherapy was administered once weekly for 3 weeks followed by 1 week rest. After 3 courses, CEA decreased markedly and CT revealed remarkable tumor reduction which was thought to show a partial response (PR). After 6 courses, PR was continued. Adverse effects were only grade 1 alopecia and leukopenia. No major adverse effects were observed. These results suggest that hepatic arterial injection therapy with weekly paclitaxel is effective against recurrent gastric cancer with liver metastases.
Kanno
Hirotaka
H
Dept. of Surgery, Yonezawa Municipal Hospital.
Kitamura
Masatoshi
M
Suzuki
Yuzuru
Y
Imai
Kouji
K
Watanabe
Kouji
K
D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005743:Gastrectomy; D006499:Hepatic Artery; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage*; D011184:Postoperative Period; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel