title: Management of muscle invasive bladder cancer--British approaches to organ conservation.
abstract: British groups have long favored a more conservative approach to the management of invasive bladder cancer. They have been involved in several randomized trials looking at the efficacy of these approaches and have also been leaders in the study of neoadjuvant chemotherapy. This article documents the concerns that linger over the efficacy and morbidity of cisplatin-based chemotherapy and describes a national trial investigating a potentially less morbid 5FU and mitomycin alternative.
authors.affiliation: Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK.
authors.forename: Nicholas
authors.initials: N
authors.lastname: James
authors.forename: Syed A
authors.initials: SA
authors.lastname: Hussain
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D016685:Mitomycin / Q000008:administration & dosage; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D016032:Randomized Controlled Trials as Topic; D006113:United Kingdom; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
chemical_list: D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D016685:Mitomycin; D002945:Cisplatin; D005472:Fluorouracil