Cortical thickness of the frontopolar area in typically developing children and adolescents.
The development of the frontopolar cortex (FPC) through late childhood and adolescence was investigated using measures of cortical thickness. T(1)-weighted structural MRIs from 35 typically developing participants aged 8-20 years were used to construct 3D models of the brain, from which cortical thickness was measured. There was a significant inverse association between age and cortical thickness, such that cortical thickness decreased as age increased between 8 and 20 years. There was no effect of laterality or gender on cortical thickness.
O'Donnell
Shannon
S
Brain and Behaviour Program, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
Noseworthy
Michael D
MD
Levine
Brian
B
Dennis
Maureen
M
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000254:growth & development*; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000254:growth & development*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012727:Sex Characteristics; D014793:Visual Cortex / Q000033:anatomy & histology / Q000254:growth & development