Analgesic and antipyretic activities of the aqueous extract of Urtica macrorrhiza in experimental animals.
Oral administration of the aqueous extract of the stem of Urtica macrorrhiza (100-400 mg/kg) dose dependently reduced the number of writhings and stretchings induced by acetic acid and decreased licking activity of the late phase in formalin test at doses of 200 and 400 mg/kg. At doses of 200 and 400 mg/kg, p.o. it suppressed yeast-induced fever in rats.
Yongna
Zhao
Z
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Kunming Medical College, Kunming, Yunnan, 650031, PR China. mszhaoyn@yahoo.com.cn
Wantana
Reanmongkol
R
Pisit
Bouking
B
Zhongkun
Li
L
Rongping
Zhang
Z
D019342:Acetic Acid; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000517:prevention & control*; D005557:Formaldehyde; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D051381:Rats; D027003:Urticaceae; D015003:Yeasts
D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D005557:Formaldehyde; D019342:Acetic Acid