[Epigenetic post-transcriptional mechanisms for regulating physiological functions, and their decline during aging].
Sequencing of genomes did not reveal the "secret of life" and left biologists and philosophers unsatisfied. It became clear that post-genetic, epigenetic (taken in a wide sense, post-translational) events play an important role even during development and adult homeostasis. Such mechanisms become predominant during aging, and explain the differential decline of functions (aging in "spare-parts"). Some of these post-translational mechanisms, leading to auto-amplifying vicious circles, will be described.
Robert
Ladislas
L
Laboratoire de Recherche Ophtalmologique, Université Paris 5, Hôpital Hôtel Dieu, 1, place du Parvis Notre-Dame, 75181 Paris Cedex 04. lrobert5@wanadoo.fr
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D044127:Epigenesis, Genetic; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006133:Growth Substances / Q000502:physiology; D006706:Homeostasis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008136:Longevity / Q000235:genetics / Q000502:physiology; D020935:MAP Kinase Signaling System / Q000502:physiology; D008875:Middle Aged; D008954:Models, Biological; D010084:Oxidation-Reduction; D011499:Protein Processing, Post-Translational; D011956:Receptors, Cell Surface / Q000378:metabolism
D017127:Glycation End Products, Advanced; D006133:Growth Substances; D011956:Receptors, Cell Surface