title: [F-wave amplitude in peripheral nervous system lesions].
abstract: OBJECTIVE
  F-wave is a late response recorded from muscle elicited by electric impulse conveyed antidromically to alpha-motor neurons of the spinal cord. F-wave latency and frequency are assessed in routine electroneurography providing information of conduction in the proximal segment of the nerves. F-wave amplitude is rarely analyzed, while it could add valuable information on excitability of motor neurons in different disease states. This study was conducted to determine whether F-wave amplitude is indicative of the level of the peripheral nervous system lesion.
  
  
  METHODS
  EMG recordings of 204 consecutive patients suspected of peripheral nerves system lesion were retrospectively analyzed. Based on the clinical diagnosis three groups were defined: neuropathy (N=100), myopathy (N=33), ALS (N=18), reference (musculoskeletal pain syndromes: N=53). F-wave amplitude and F/CMAP-ratio (CMAP-compound motor action potential) and their relation to parameters of impulse conduction in motor nerve fibers was analyzed.
  
  
  RESULTS
  Mean F/CMAP ratio was 11.1% in ALS, 5% in myopathy (p=0.008), 7.1% in neuropathies and 5.6% in the reference group. Giant F-wave (more than 10% of CMAP) was observed in 30% of nerves in ALS, 15% in neuropathy and 10% in myopathy (p=0.036). F-wave amplitude correlated significantly with CMAP amplitude in all groups, while F/CMAP ratio was inversely related to CMAP amplitude in ALS (r=-0.43, p<0.01) and neuropathy (r=-0.37, p<0.0001). F-wave frequency was similar in all groups and correlated with CMAP amplitude.
  
  
  CONCLUSIONS
  F-wave amplitude is not indicative of the level of peripheral nervous system lesions. Giant F-wave is observed in neurogenic processes. It reflects an increase of motor unit size in the reinnervation process, but possibly also a change of excitability of motor neuron and its axon.
authors.affiliation: Klinika Neurologii, Akademia Medyczna, Warsaw.
authors.forename: Anna
authors.initials: A
authors.lastname: Kostera-Pruszczyk
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Rowińska-Marcińska
authors.forename: Szymon
authors.initials: S
authors.lastname: Owsiak
authors.forename: Paweł
authors.initials: P
authors.lastname: Jezierski
authors.forename: Barbara
authors.initials: B
authors.lastname: Emeryk-Szajewska
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D004576:Electromyography; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D008297:Male; D009135:Muscular Diseases / Q000175:diagnosis; D009140:Musculoskeletal Diseases / Q000175:diagnosis*; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis*; D012189:Retrospective Studies