title: Radiation-induced angiosarcoma after mastectomy and TRAM flap breast reconstruction.
abstract: Radiation-induced angiosarcoma of the breast is being reported with increasing frequency as a result of the increased use of radiation therapy in conjunction with breast conservation surgery. However, this entity has not been well documented in patients undergoing mastectomy. The authors present a case of angiosarcoma occurring in a patient 6 years after undergoing mastectomy for invasive duct carcinoma with immediate transverse rectus abdominis musculocutaneous flap reconstruction followed by postoperative radiation therapy. The diagnosis of angiosarcoma was made by skin biopsy performed by the patient's reconstructive surgeon on routine follow-up examination. This is the first reported case of postradiation angiosarcoma occurring in a postmastectomy breast reconstructed with autogenous tissue and it is unusual in that the cancer invaded the musculocutaneous flap. Diagnosis and management recommendations for radiation-induced angiosarcoma are discussed.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY 10021, USA.
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Hanasono
authors.forename: Michael P
authors.initials: MP
authors.lastname: Osborne
authors.forename: Elodi J
authors.initials: EJ
authors.lastname: Dielubanza
authors.forename: Sara B
authors.initials: SB
authors.lastname: Peters
authors.forename: Lloyd B
authors.initials: LB
authors.lastname: Gayle
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000601:surgery*; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000378:metabolism; D016462:Mammaplasty; D015411:Mastectomy, Modified Radical; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000601:surgery*; D013524:Surgical Flaps
chemical_list: D019394:Ki-67 Antigen