Invasive ductal carcinoma of the breast with a large central acellular zone associated with matrix-producing carcinoma.
Matrix-producing carcinoma is a variant of metaplastic carcinoma of the breast that consists of overt carcinoma with direct transition to a cartilagenous and osseous stromal matrix. A clinicopathological association between MPC and high-grade invasive ductal carcinoma with a large central acellular zone has been recently discussed. However, few reports have ever shown the radiological, pathological and immunohistochemical correlation of this unique tumor. We present a case of 27-year-old woman with matrix-producing carcinoma with a large central acellular zone, which was characterized by a large homogeneous hypodense center with well-marginated, ring-like enhancement on contrast enhanced computerized tomography.
Hama
Yukihiro
Y
Department of Radiology, National Defense Medical College, Namiki, Tokorozawa, Saitama, Japan. yjhama@me.ndmc.ac.jp
Tsuda
Hitoshi
H
Sato
Kazuhiko
K
Hiraide
Hoshio
H
Mochizuki
Hidetaka
H
Kusano
Shoichi
S
D000328:Adult; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005109:Extracellular Matrix / Q000473:pathology; D005260:Female; D006801:Humans; D008679:Metaplasia; D011859:Radiography