In vivo rat metabolism and pharmacokinetic studies of ginsenoside Rg3.
Metabolism of an anti-tumor active component of Panax ginseng, ginsenoside (20R)-Rg(3), was studied for better understanding its pharmacokinetics in rat. LC-MS was used to determine Rg(3) and its metabolites in rat plasma, urine and feces samples. An average half-life of 18.5 min was obtained after the ginsenoside was intravenously dosed at 5 mg/kg. However, Rg(3) was not detected in rat plasma collected after oral administration at 100 mg/kg. Only 0.97-1.15% Rg(3) of the dosed amount was determined in feces. Hydrolysis and oxygenated metabolites were detected and identified in feces collected after oral administration by using LC-MS and MS-MS.
Qian
Tianxiu
T
Department of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon, Hong Kong, SAR, China.
Cai
Zongwei
Z
Wong
Ricky N S
RN
Mak
Nai Ki
NK
Jiang
Zhi-Hong
ZH
D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000378:metabolism* / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000737:chemistry; D041981:Gastrointestinal Tract / Q000378:metabolism; D036145:Ginsenosides / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization
D000972:Antineoplastic Agents, Phytogenic; D036145:Ginsenosides; C097367:ginsenoside Rg3