Natural vanadium-containing Mt. Fuji ground water improves hypo-activity of liver insulin receptor in Goto-Kakisaki rats.
After daily treatments with Mt. Fuji ground water containing natural vanadium (approximately 65 microg/l) at doses of 0.53 microg/kg/day for 12 weeks, blood glucose (BG), serum hemoglobin A1C (HbA1C) levels and insulin secretion from the pancreas of Goto-Kakisaki (GK) rats, a genetic model of Type 2 diabetes, were improved. In GK rat liver insulin receptors, the binding properties of [125I] insulin, and the activities of insulin receptor beta subunit and primary insulin-like growth factor-1beta all recovered to normal levels of those found in Wistar rats. These results suggest that daily treatment with small concentrations of natural vanadium improves hyperglycemia by ameliorating liver insulin receptor activity.
Kato
Katsuhiko
K
Department of General Education, School of Veterinary Medicine, University of Azabu, Kanagawa, Japan.
Yamada
Shizuo
S
Ohmori
Yuki
Y
Oki
Tomomi
T
Kawamoto
Eiichi
E
Shirama
Kazuhiko
K
Watanabe
Yasuo
Y
D000284:Administration, Oral; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001786:Blood Glucose / Q000187:drug effects; D015153:Blotting, Western; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004195:Disease Models, Animal; D005618:Fresh Water / Q000737:chemistry*; D006442:Glycated Hemoglobin / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007457:Iodine Radioisotopes; D008099:Liver / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar; D011972:Receptor, Insulin / Q000378:metabolism*; D013997:Time Factors; D014639:Vanadium / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D007457:Iodine Radioisotopes; D011972:Receptor, Insulin; D014639:Vanadium