title: Anaphylaxis with associated fibrinolysis, reversed with tranexamic acid and demonstrated by thrombelastography.
abstract: In the surgical setting, fibrinolysis can be a serious complication of anaphylaxis. We present four cases of anaphylaxis that were associated with fibrinolysis during anaesthesia, and the use of the thrombelastograph to demonstrate this haemostatic defect and its correction using tranexamic acid.
authors.affiliation: Anaesthetic Department, Auckland Hospital, Auckland, New Zealand.
authors.forename: R L
authors.initials: RL
authors.lastname: De Souza
authors.forename: T
authors.initials: T
authors.lastname: Short
authors.forename: G R
authors.initials: GR
authors.lastname: Warman
authors.forename: N
authors.initials: N
authors.lastname: Maclennan
authors.forename: Y
authors.initials: Y
authors.lastname: Young
mesh_terms: D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000097:blood* / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D007431:Intraoperative Complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D013916:Thrombelastography; D014148:Tranexamic Acid / Q000627:therapeutic use*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid