title: Early virological failure in treatment-naive HIV-infected adults receiving didanosine and tenofovir plus efavirenz or nevirapine.
abstract: A 50% rate of early virological failure associated with the selection of resistance mutations was seen in a group of 14 antiretroviral-naive adults who initiated highly active antiretroviral therapy with tenofovir and didanosine plus efavirenz or nevirapine. At month 6, the mutations detected were K65R, L74V, L100I, K103N/R/T, Y181C and G190E/Q/S. These results argue against the use of tenofovir plus didanosine in HIV-infected antiretroviral-naive adults even when the third drug is a non-nucleoside reverse transcriptase inhibitor.
authors.affiliation: Infectious Diseases Unit, Hospital Clinic, University of Barcelona, Spain.
authors.forename: Agathe
authors.initials: A
authors.lastname: León
authors.forename: Esteban
authors.initials: E
authors.lastname: Martinez
authors.forename: Josep
authors.initials: J
authors.lastname: Mallolas
authors.forename: Montserrat
authors.initials: M
authors.lastname: Laguno
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Blanco
authors.forename: Tomás
authors.initials: T
authors.lastname: Pumarola
authors.forename: Josep María
authors.initials: JM
authors.lastname: Gatell
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000328:Adult; D000368:Aged; D000480:Alkynes; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D048588:Benzoxazines; D003521:Cyclopropanes; D016049:Didanosine / Q000008:administration & dosage*; D024882:Drug Resistance, Viral; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019829:Nevirapine / Q000009:adverse effects*; D063065:Organophosphonates / Q000008:administration & dosage*; D010078:Oxazines / Q000008:administration & dosage*; D012367:RNA, Viral / Q000032:analysis; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage; D000068698:Tenofovir
chemical_list: D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; D063065:Organophosphonates; D010078:Oxazines; D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine; D000068698:Tenofovir; D000225:Adenine; C098320:efavirenz; D016049:Didanosine