Effects of dimephosphone, xydiphone, and ionol on the content and activities of rat liver cytochromes P-450 during long-term treatment with phenobarbital.
Effects of dimephosphone, xydiphone, and ionol administered in parallel with phenobarbital on the content of cytochromes P-450 in rat liver and on the rate of C-hydroxylation of diazepam, haloperidol, and prednisolone by rat liver microsomal enzymes were studied in vitro. Dimephosphone, xydiphone, and ionol exhibited similar inductive effects on C-hydroxylation reactions in the CYP P-450 system during treatment with phenobarbital. Xydiphone and ionol in a dose of 1 mmol/kg canceled phenobarbital-induced increase in P-450 cytochrome content in rat liver. Sex-dependent cytochromes P-450 are involved in the prednisolone and haloperidol C-hydroxylation reactions in rats.
Ziganshina
L E
LE
Department of Clinical Pharmacology and Drug Therapy, Kazan State Medical University. lezign@mail.ru
Fattakhova
A N
AN
Vedernikova
O O
OO
Ziganshin
A U
AU
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism; D012968:Etidronic Acid / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000378:metabolism; D006900:Hydroxylation; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology; D011239:Prednisolone / Q000378:metabolism; D051381:Rats; D012727:Sex Characteristics
D009943:Organophosphorus Compounds; C049638:dimephosphon; D002084:Butylated Hydroxytoluene; D003577:Cytochrome P-450 Enzyme System; D011239:Prednisolone; D006220:Haloperidol; D012968:Etidronic Acid; D003975:Diazepam; D010634:Phenobarbital