title: Ergosterol peroxide, an apoptosis-inducing component isolated from Sarcodon aspratus (Berk.) S. Ito.
abstract: Among the lipophilic extracts of seven traditional edible mushrooms, the acetone extract of Sarcodon aspratus markedly inhibited the growth of HL60 human leukemia cells and induced apoptosis after 24 h incubation. The major active component was identified as ergosterol peroxide by NMR and ESI-MS analysis. Ergosterol peroxide completely inhibited growth and induced apoptosis of HL60 cells at a concentration of 25 microM.
authors.affiliation: Fukushima Prefectural Forestry Research Centre, Fukushima, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takei
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Yoshida
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ohnishi-Kameyama
authors.forename: Masuko
authors.initials: M
authors.lastname: Kobori
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D001487:Basidiomycota / Q000737:chemistry*; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D013997:Time Factors
chemical_list: C036071:ergosterol-5,8-peroxide; D004875:Ergosterol