Blood pressure change with age in salt-sensitive teenagers.
OBJECTIVE
To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.


METHODS
Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.


RESULTS
After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7 +/- 12.1 mmHg vs. 2.8 +/- 5.2 mmHg, P < 0.01; 12.2% +/- 12.0% vs. 2.5% +/- 4.4%, P < 0.001, respectively). There was a similar trend for diastolic blood pressure (8.4 +/- 6.4 mmHg vs. 3.7 +/- 6.4 mmHg, P = 0.052; 13.2% +/- 10.6% vs. 6.8% +/- 10.1%, P = 0.053, respectively).


CONCLUSIONS
Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.
Ye
Tao
T
Department of Cardiology, First Hospital of Xi'an Jiaotong University, Xi'an 710061. yetao8@sina.com
Liu
Zhi-quan
ZQ
Mu
Jian-jun
JJ
Fu
Xi-han
XH
Yang
Jun
J
Gao
Bao-lin
BL
Zhang
Xiao-hong
XH
D000293:Adolescent; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects*; D001810:Blood Volume; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D013599:Systole
D012965:Sodium Chloride; D005665:Furosemide