Redefining neuroprotective gene therapeutic strategies: Lessons learned from caloric restriction and NAD(+) metabolism.
Herein a case is made for the development of novel cytoprotective approaches based upon molecular mechanisms thought to underlie the caloric restriction phenomenon. This analysis leads to the prediction that molecular genetic perturbations affecting the metabolism of nuclear NAD(+) and metabolites will be neuroprotective.
Henricksen
L A
LA
Center for Aging and Developmental Biology, Aab Institute for Biomedical Sciences, University of Rochester School of Medicine and Dentistry, Rochester, MN, USA. Howard_Federoff@urmc.rochester.edu
Federoff
H J
HJ
D000544:Alzheimer Disease / Q000201:enzymology / Q000235:genetics / Q000517:prevention & control; D019732:Amide Synthases / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D031204:Caloric Restriction / Q000379:methods*; D002540:Cerebral Cortex / Q000201:enzymology; D004330:Drosophila; D002149:Energy Intake; D005247:Feeding Behavior; D018014:Gene Transfer Techniques / Q000295:instrumentation; D015316:Genetic Therapy / Q000379:methods*; D009474:Neurons / Q000201:enzymology; D018384:Oxidative Stress / Q000502:physiology; D012307:Risk Factors
D019732:Amide Synthases; C038479:NAD+ synthase