title: Enhanced optical coherence tomography imaging by multiple scan averaging.
abstract: OBJECTIVE
  To describe a method for computerised alignment and averaging of sequences in optical coherence tomography (OCT) B-scans and to present selected clinical observations based on the resulting improvement in retinal imaging.
  
  
  METHODS
  A methodological study and retrospective investigation of selected cases. Five human subjects were included, one healthy subject, two patients with central serous chorioretinopathy, one patient with branch retinal vein occlusion, and one patient with cilioretinal artery pseudo-occlusion. Based on computerised alignment of sets of B-scans obtained at identical retinal locations, average OCT images were produced and displayed in false colour or grayscale. These enhanced tomograms were compared with other morphological and functional characteristics.
  
  
  RESULTS
  Improved retinal imaging enabled assignment of the OCT image to retinal anatomy particularly at the outer layer of the photoreceptors and the retinal pigment epithelium, both in the healthy eye and in pathology. Identification of both post-oedematous structural disorganisation as well as post-ischaemic attenuation of the inner retina was superior to standard OCT images.
  
  
  CONCLUSIONS
  Averaging of multiple OCT B-scans enhances the quality of retinal imaging sufficiently to reveal new details of retinal pathophysiology. Using the technique on OCT3 scans enables visualisation of details comparable with the results obtained using ultra high resolution OCT.
authors.affiliation: Department of Ophthalmology, Herlev Hospital, DK-2730 Herlev, Denmark. bisan@herlevhosp.kbhamt.dk
authors.forename: B
authors.initials: B
authors.lastname: Sander
authors.forename: M
authors.initials: M
authors.lastname: Larsen
authors.forename: L
authors.initials: L
authors.lastname: Thrane
authors.forename: J L
authors.initials: JL
authors.lastname: Hougaard
authors.forename: T M
authors.initials: TM
authors.lastname: Jørgensen
mesh_terms: D000328:Adult; D015862:Choroid Diseases / Q000473:pathology; D019842:Ciliary Arteries / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D010786:Photoreceptor Cells / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012160:Retina / Q000473:pathology*; D015356:Retinal Artery Occlusion / Q000473:pathology; D012164:Retinal Diseases / Q000473:pathology*; D012170:Retinal Vein Occlusion / Q000473:pathology; D012171:Retinal Vessels / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*