title: Ketogenic diet in pediatric epilepsy patients with gastrostomy feeding.
abstract: Ketogenic diet is effective in the control of intractable seizures. Poor compliance is a major limiting factor. In one study, only 50% of children receiving the oral ketogenic diet remained on the diet after 1 year. Twelve children with static encephalopathy and intractable symptomatic epilepsy were given the ketogenic diet via gastrostomy tube. Mean age was 3 years (range, 7 months to 6.5 years). Mean seizure frequency at baseline was 199/month. Seizure frequency after 12 and 18 months of diet was compared with baseline. After 12 months on the diet, the number of antiepileptic drugs was compared with baseline. Median seizure reduction at 1 year and 18 months was 61% and 66%, respectively (P = 0.02). Individually, six patients had 90% seizure reduction, one had 75% reduction, three had 50% reduction, and two patients did not improve. Mean antiepileptic drugs at baseline was 2.8; at 12 months 1.6 (49% reduction). Three patients had weight loss. Two patients discontinued the diet at 13 months and 21 months, respectively, because of diarrhea and weight loss. Compliance with diet was 100% during treatment. This study suggests that the ketogenic diet via gastrostomy feeding tube is safe and effective in children with intractable seizures and ensures compliance.
authors.affiliation: Division of Pediatric Epilepsy, Department of Pediatrics, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA.
authors.forename: Syed A
authors.initials: SA
authors.lastname: Hosain
authors.forename: Maite
authors.initials: M
authors.lastname: La Vega-Talbott
authors.forename: Gail E
authors.initials: GE
authors.lastname: Solomon
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000209:etiology; D004035:Diet Therapy / Q000009:adverse effects; D004750:Enteral Nutrition; D004827:Epilepsy / Q000150:complications / Q000178:diet therapy* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007657:Ketone Bodies / Q000378:metabolism; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D000927:Anticonvulsants; D007657:Ketone Bodies