title: [Gene expression of type X collagen in the intervertebral disc of idiopathic scoliosis patients].
abstract: OBJECTIVE
  To observe the characteristics of gene expression of type X collagen in the cartilage of end-plate and the fibrous annulus in the intervertebral disc of idiopathic scoliosis (IS) patients.
  
  
  METHODS
  Investigating the expression of type X collagen in the peak disc and the lower end disc of 21 IS patients, the peak disc of 16 congenital scoliosis (CS) and the lumbar disc of 3 normal people (according with the principle of medical ethnics) by reverse transcript polymerase chain reaction.
  
  
  RESULTS
  The expression of type X collagen in the concave side of IS peak disc was higher than the convex side (P < 0.05). There was no significant difference of gene expression of type X collagen between the convex side and the concave side of the lower end disc (P > 0.05). The gene expression of type X collagen in the IS peak disc was higher than those of lower end disc (P < 0.05). For the CS peak discs, the expression of type X collagen of the concave side was higher than the convex side (P < 0.05).
  
  
  CONCLUSIONS
  The expression of type X collagen of the IS peak disc increases, and the expression of type X collagen of the concave side is higher than the convex side. These changes may be secondary.
authors.affiliation: Department of Orthopaedic Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Lin
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wu
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Yi-Peng
authors.initials: YP
authors.lastname: Wang
authors.forename: Xi-Sheng
authors.initials: XS
authors.lastname: Weng
authors.forename: Jin
authors.initials: J
authors.lastname: Lin
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Jian-Xiong
authors.initials: JX
authors.lastname: Shen
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Zhang
authors.forename: Gui-Xing
authors.initials: GX
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D002648:Child; D024121:Collagen Type X / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism*; D008297:Male; D012600:Scoliosis / Q000235:genetics / Q000378:metabolism*
chemical_list: D024121:Collagen Type X