Differential immune induction with subcutaneous versus oral administration of a diabetogenic insulin peptide in the NOD mouse.
The B chain insulin peptide 9 to 23 (B:9-23) is a dominant T cell epitope of the NOD mouse. Given in oral form with multiple different vehicles, it did not alter expression of insulin autoantibodies in contrast to subcutaneous administration.
Devendra
Devasenan
D
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
Paronen
Johanna
J
Liu
Edwin
E
Moriyama
Hiroaki
H
Miao
Dongmei
D
Yu
Liping
L
Eisenbarth
George S
GS
D000284:Administration, Oral; D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D018928:Immunity, Mucosal; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage* / Q000276:immunology; D051379:Mice; D016688:Mice, Inbred NOD; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies; D007328:Insulin; D010446:Peptide Fragments; C097877:insulin B (9-23)