Acetazolamide-enhanced neuroSPECT scan reveals functional impairment after minimal traumatic brain injury not otherwise discernible.
A patient suffering from aggressive personality changes and cognitive impairment following head trauma, without neurological or anatomical imaging findings, underwent neuroSPECT scans with and without acetazolamide injection, both before treatment and during treatment with valproate. Acetazolamide injection induced increased prefrontal perfusion not evident at baseline. Valproate treatment was associated with increased prefrontal perfusion concomitant with clinical improvement and abolished response to acetazolamide challenge.
Barkai
Gavriel
G
Department of Psychiatry, Tel Aviv Sourasky Medical Center and Tel Aviv University Sackler Faculty of Medicine, 6 Weizmann St., Tel Aviv 64239, Israel.
Goshen
Elinor
E
Tzila Zwas
S
S
Dolberg
Ornah T
OT
Pick
Chaim G
CG
Bonne
Omer
O
Schreiber
Shaul
S
D000086:Acetazolamide / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D001921:Brain / Q000098:blood supply*; D001930:Brain Injuries / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010554:Personality Disorders / Q000175:diagnosis / Q000209:etiology; D012039:Regional Blood Flow / Q000187:drug effects; D015899:Tomography, Emission-Computed, Single-Photon; D014635:Valproic Acid / Q000494:pharmacology* / Q000627:therapeutic use
D002257:Carbonic Anhydrase Inhibitors; D014635:Valproic Acid; D000086:Acetazolamide