title: Orphan GPCR target validation.
abstract: Nearly half of the identified non-olfactory G protein-coupled receptors (GPCRs) have no identified cognate ligand. These 'orphan' receptors are likely to have important physiological roles that could potentially be exploited therapeutically. However, by definition, such receptors are not immediately open for pharmacological investigation of their function. Here we summarize several strategic approaches to facilitate the discovery of orphan GPCR biology.
authors.affiliation: Arena Pharmaceuticals Inc, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA.
authors.forename: William
authors.initials: W
authors.lastname: Thomsen
authors.forename: James
authors.initials: J
authors.lastname: Leonard
authors.forename: Dominic P
authors.initials: DP
authors.lastname: Behan
mesh_terms: D000818:Animals; D018390:Gene Targeting / Q000379:methods*; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: D016376:Oligonucleotides, Antisense; D043562:Receptors, G-Protein-Coupled