title: Cognitive functioning in community dwelling older adults with chronic partial epilepsy.
abstract: OBJECTIVE
  To examine cognitive functioning in community-dwelling older adults with chronic partial epilepsy and demographically matched healthy older adults.
  
  
  METHODS
  Standardized measures of neurocognitive function were collected as part of an ongoing study investigating health-related quality-of-life issues in older adults with epilepsy. Cognitive tests consisted of the Mattis Dementia Rating Scale (subscales include attention, initiation/perseveration, construction, conceptualization, memory), Logical Memory subtest from the WMS-III (immediate and delayed recall scores), and word fluency. Mood was measured with the Geriatric Depression Scale. Older adults with epilepsy (n=25) and healthy older adults (n=27) completed testing. All participants were at least 60 years old, living independently in the community, and had no history of drug/alcohol abuse or life-threatening medical conditions. All older adults with epilepsy had been diagnosed as having medically intractable partial complex seizures, including those with histories of secondary generalization.
  
  
  RESULTS
  Older adults with epilepsy demonstrated impairments across all cognitive measures compared with the healthy controls. Seizure onset (age) and seizure duration (years) were not statistically associated with neurocognitive function or self-reported mood. Older adults with epilepsy who were receiving antiepileptic drug (AED) polytherapy (n=11) displayed worse performance on the attention, initiation/perseveration, and memory subscales of the DRS and Logical Memory delayed recall score compared with those older adults with epilepsy receiving monotherapy (n=14). The number of AEDs taken was not associated with seizure frequency.
  
  
  CONCLUSIONS
  Negative effects on cognitive function are experienced by older adults with chronic partial epilepsy. AED polytherapy may increase the risk for negative cognitive dysfunction.
authors.affiliation: Department of Neurology, UAB Epilepsy Center Birmingham, Birmingham, Alabama 35294-0021, USA. rmartin@uab.edu
authors.forename: Roy C
authors.initials: RC
authors.lastname: Martin
authors.forename: H Randall
authors.initials: HR
authors.lastname: Griffith
authors.forename: Edward
authors.initials: E
authors.lastname: Faught
authors.forename: Frank
authors.initials: F
authors.lastname: Gilliam
authors.forename: Melissa
authors.initials: M
authors.lastname: Mackey
authors.forename: Laura
authors.initials: L
authors.lastname: Vogtle
mesh_terms: D000339:Affect / Q000187:drug effects; D017668:Age of Onset; D000368:Aged; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use; D002908:Chronic Disease; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000175:diagnosis*; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012111:Residence Characteristics
chemical_list: D000927:Anticonvulsants