[Change of peripheral blood monocytes derived macrophage scavenger receptors activity in patients with coronary heart disease, and the intervention effect of ginkgo biloba extract].
OBJECTIVE
To observe the activity of peripheral blood monocytes (PBMs) derived macrophage scavenger receptors (MSR) and changes of serum inflammatory factor in peripheral blood in patients with coronary heart disease (CHD), and to evaluate the effect of Ginkgo biloba extract (GBE) on the MSR activity, to explore the relationship between inflammatory factor and scavenger receptors activity as well as the possible mechanism of GBE in stabilizing the atheromatous plaque.


METHODS
Ninety-seven CHD patients with normal blood lipids were classified into the stable angina group, the unstable angina group and the acute myocardial infarction group, and 29 healthy persons were taken as control. Levels of C-reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in all subjects were determined. And their PBMs were isolated, cultured in vitro, and transferred into macrophage to observe the effect of GBE on the expression of scavenger receptors.


RESULTS
The levels of MSR activity, CRP, sICAM-1 and sVCAM-1 in patients with acute myocardial infarction > unstable angina > stable angina > control.


CONCLUSIONS
GBE could down-regulate the MSR activity in CHD patients, which was positively correlated with levels of CRP, sICAM-1 and sVCAM-1. MSR activity could be taken as a monitoring criteria for active degree of vulnerable atherosclerosis plaque. GBE has the effect of suppressing MSR activity.
Zhu
Gui-Yue
GY
Department of Cardiology, Shandong Provincial Hospital, Shandong University, Jinan 250021. zhuguiyue@126.com
Zhu
Xing-Lei
XL
Geng
Qing-Xin
QX
Zhang
Xinghua
X
Shao
Jianhua
J
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D008517:Phytotherapy; D011971:Receptors, Immunologic / Q000097:blood*; D051116:Receptors, Scavenger; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D004365:Drugs, Chinese Herbal; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1