title: Modeling in vivo pharmacokinetics and pharmacodynamics of moxifloxacin therapy for Mycobacterium tuberculosis infection by using a novel cartridge system.
abstract: To study the efficacy of moxifloxacin treatment for tuberculosis, we utilized a novel cartridge system to simulate in vivo pharmacokinetics. We found this system to be a robust method for modeling in vivo pharmacokinetics and present data supporting the utility of intermittent moxifloxacin treatment as a component of antituberculosis chemotherapy.
authors.affiliation: Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: Amy Sarah
authors.initials: AS
authors.lastname: Ginsburg
authors.forename: Jin
authors.initials: J
authors.lastname: Lee
authors.forename: Samuel C
authors.initials: SC
authors.lastname: Woolwine
authors.forename: Jacques H
authors.initials: JH
authors.lastname: Grosset
authors.forename: Fayez M
authors.initials: FM
authors.lastname: Hamzeh
authors.forename: William R
authors.initials: WR
authors.lastname: Bishai
mesh_terms: D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001372:Aza Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D003198:Computer Simulation; D024841:Fluoroquinolones; D006207:Half-Life; D007260:Infusion Pumps; D008954:Models, Biological; D000077266:Moxifloxacin; D011804:Quinolines / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin