Gene expression profiling in chronic inflammatory demyelinating polyneuropathy.
Gene expression in archived frozen sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was compared to that in vasculitic nerve biopsies (VAS) and to normal nerve (NN) by DNA microarray technology. Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups. Of particular interest were: (1) Tachykinin precursor 1, which may be involved in pain mediation; (2) Stearoyl-CoA-desaturase, which may be a marker for remyelination and (3) the Allograft Inflammatory Factor 1 (AIF-1), a modulator of immune response during macrophage activation. Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis.
Renaud
Susanne
S
Department of Neurology and Neurosciences, Weill Medical College, Cornell University, New York, NY, USA. susanne.renaud@unibas.ch
Hays
Arthur P
AP
Brannagan
Thomas H
TH
Sander
Howard W
HW
Edgar
Mark
M
Weimer
Louis H
LH
Olarte
Marcelo R
MR
Dalakas
Marinos C
MC
Xiang
Zhaoying
Z
Danon
Moris J
MJ
Latov
Norman
N
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000235:genetics* / Q000473:pathology*; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D011115:Polyneuropathies / Q000235:genetics* / Q000473:pathology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000235:genetics; D013497:Sural Nerve / Q000473:pathology; D015854:Up-Regulation