title: N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists.
abstract: The synthesis and structure-activity relationships of N-arylalkylpiperidylmethyl ureas as antagonists of the CC chemokine receptor-3 (CCR3) are presented. These compounds displayed potent binding to the receptor as well as functional antagonism of eotaxin-elicited effects on eosinophils.
authors.affiliation: dBristol-Myers Squibb, Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA. douglas.batt@bms.com
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Batt
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Houghton
authors.forename: John
authors.initials: J
authors.lastname: Roderick
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Santella
authors.forename: Dean A
authors.initials: DA
authors.lastname: Wacker
authors.forename: Patricia K
authors.initials: PK
authors.lastname: Welch
authors.forename: Yevgeniya I
authors.initials: YI
authors.lastname: Orlovsky
authors.forename: Eric A
authors.initials: EA
authors.lastname: Wadman
authors.forename: James M
authors.initials: JM
authors.lastname: Trzaskos
authors.forename: Paul
authors.initials: P
authors.lastname: Davies
authors.forename: Carl P
authors.initials: CP
authors.lastname: Decicco
authors.forename: Percy H
authors.initials: PH
authors.lastname: Carter
mesh_terms: D020013:Calcium Signaling / Q000187:drug effects; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000494:pharmacology; D004347:Drug Interactions; D004804:Eosinophils / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011485:Protein Binding; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014508:Urea / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C515456:CCL11 protein, human; C515350:CCR3 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D010880:Piperidines; D054397:Receptors, CCR3; D019707:Receptors, Chemokine; D014508:Urea