[The experimental research of Atractylodes macrocephala and Poria cocos on the meridian tropism theory in animals].
OBJECTIVE
The research was designed to study the meridian tropism theory of traditional Chinese drug through experiments in animals.


METHODS
We used the mouse model of deficient spleen as the object. After administering Atractylodes macrocephala and Poria cocos respectively, we measured the indexes of MDA, SOD, NO to observe the effects of the drugs on various organs and compared the results with the traditional meridian tropism theory.


RESULTS
The two drugs had selective effects on the quantity or activity of MDA, SOD, NO in the organs for the normal group and the model group.


CONCLUSIONS
The selective influence of the two drugs has close relativity with the traditional meridian tropism theory.
Wang
Shu-rong
SR
Department of Pharmacology, Shandong University of Traditional Chinese Medicine, Jinan 250014, China. wangshr@sdutcm.edu.cn
Wang
Xin
X
Hu
Shuang
S
D000818:Animals; D031174:Atractylodes / Q000737:chemistry; D003677:Deficiency Diseases / Q000139:chemically induced / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D008297:Male; D008516:Medicine, Chinese Traditional; D016740:Meridians; D051379:Mice; D020072:Polyporales / Q000737:chemistry; D012250:Rheum; D013158:Splenic Diseases / Q000139:chemically induced / Q000378:metabolism*
D004365:Drugs, Chinese Herbal