How to study boron biodistribution in liver metastases from colorectal cancer.
The purpose of this study was to evaluate boron distribution for a safe and effective BNCT (Boron Neutron Capture Therapy) of liver metastases. Samples both from healthy and tumour liver parenchyma were analysed, after i.v. boron administration, by: alpha particles counting under neutron irradiation; morphological analysis by standard haematoxylin-eosin staining; neutron autoradiography. Our method was unaffected by the cytological heterogeneity inside tumour nodules; it demonstrated selective boron distribution in tumour tissue and predicted estimated mean therapeutic doses in tumour and safety doses in healthy tissue. The time interval for efficient BNCT was 2 to 4 hours after i.v. boron administration.
Roveda
L
L
Hepato-Pancreatic Surgery, IRCCS Pol S Matteo, Pavia, Italy.
Prati
U
U
Bakeine
J
J
Trotta
F
F
Marotta
P
P
Valsecchi
P
P
Zonta
A
A
Nano
R
R
Facoetti
A
A
Chiari
P
P
Barni
S
S
Pinelli
T
T
Altieri
S
S
Braghieri
A
A
Bruschi
P
P
Fossati
F
F
Pedroni
P
P
D000818:Animals; D001895:Boron / Q000493:pharmacokinetics*; D016754:Boron Neutron Capture Therapy; D015179:Colorectal Neoplasms / Q000473:pathology*; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D008297:Male; D051381:Rats; D014018:Tissue Distribution
D001895:Boron