Differential pulse voltammetric determination of the dopaminergic agonist bromocriptine at glassy carbon electrode.
The electrochemical oxidation of bromocriptine at glassy carbon electrode has been carried out in Britton-Robinson (B-R) buffer solutions in the pH range 2.0-11.0 employing cyclic, linear sweep and differential pulse voltammetry (DPV). Bromocriptine showed one well-defined oxidation peak accompanied by a smaller one. The oxidation process was found irreversible. For analytical purposes, the well-resolved diffusion controlled voltammetric peak at pH 5 was critically investigated. The linear relationship between peak current height and bromocriptine concentration allowed the differential pulse voltammetric determination of the drug over a wide concentration range, from 0.04 to 5.00 microg ml(-1) with a detection limit of 0.01 microg ml(-1). A relative standard deviation of 1.44% at 0.1 microg ml(-1) level was obtained. The proposed DPV method was successfully applied for the individual tablet assay to verify the uniformity content of bromocriptine in commercial tablets.
Radi
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Department of Chemistry, Faculty of Science, Mansoura University, 34517 Dumyat, Egypt. abdradi@yahoo.com
El-Shahawi
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Elmogy
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D001971:Bromocriptine / Q000032:analysis*; D002244:Carbon; D018491:Dopamine Agonists / Q000032:analysis*; D004563:Electrochemistry; D004566:Electrodes; D005898:Glass
D018491:Dopamine Agonists; D001971:Bromocriptine; D002244:Carbon