Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice.
Y-700, 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid, is a newly synthesized inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer.
Hashimoto
Takao
T
Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan.
Fukunari
Atsushi
A
Yamada
Ichimaro
I
Yanaka
Noriyuki
N
Chen
Dong
D
Kato
Norihisa
N
D019813:1,2-Dimethylhydrazine; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D003106:Colon / Q000473:pathology; D003108:Colonic Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011720:Pyrazoles / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
C433950:1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid; D011720:Pyrazoles; D014969:Xanthine Oxidase; D019813:1,2-Dimethylhydrazine