Decarboxylative Claisen rearrangement reactions of allylic tosylmalonate esters.
[reaction: see text] Two different combinations of silylating agent and base are used for one-pot [3,3]-sigmatropic rearrangement-decarboxylation reactions of tosylmalonic mono(allylic) esters under mild conditions, providing the products of formal regiospecific allylation of methyl tosylacetate at the more substituted allylic terminus.
Craig
Donald
D
Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. d.craig@imperial.ac.uk
Grellepois
Fabienne
F