In vitro activity of telithromycin against viridans group streptococci and Streptococcus bovis isolated from blood: antimicrobial susceptibility patterns in different groups of species.
The in vitro activities of penicillin, erythromycin, clindamycin, and telithromycin were determined against 155 viridans group streptococci (VGS) and 18 Streptococcus bovis blood isolates. Heterogeneity in the susceptibility patterns and macrolide resistance phenotypes and genotypes in the different groups of VGS was detected. We found seven telithromycin-resistant S. bovis isolates all harboring the erm(B) gene.
Rodríguez-Avial
Iciar
I
Servicio de Microbiología Clínica, Hospital Clínico San Carlos, Plaza de Cristo Rey s/n, 28040 Madrid, Spain. iciaravial@hotmail.com
Rodríguez-Avial
Carmen
C
Culebras
Esther
E
Picazo
Juan J
JJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002417:Cattle; D024881:Drug Resistance, Bacterial; D006801:Humans; D048628:Ketolides / Q000494:pharmacology*; D008565:Membrane Proteins / Q000378:metabolism; D008780:Methyltransferases / Q000235:genetics; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D013045:Species Specificity; D013290:Streptococcal Infections / Q000382:microbiology; D016985:Streptococcus bovis / Q000187:drug effects*; D034363:Viridans Streptococci / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D048628:Ketolides; C117866:MefA protein, Streptococcus; D008565:Membrane Proteins; D008780:Methyltransferases; C431709:ErmA protein, Bacteria; C106791:telithromycin