title: A case of disseminated Langerhans' cell histiocytosis treated with thalidomide.
abstract: Tumor necrosis factor alpha (TNF-alpha) seems to play a key role in the pathogenesis of Langerhans' cell histiocytosis (LCH). Thalidomide is an immunomodulator agent of inflammatory cytokines including TNF-alpha. To our knowledge this is the first case of disseminated LCH successfully treated with thalidomide.
authors.affiliation: Section of Hematology, Department of Biomedical Sciences, University of Ferrara, Ferrara, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Mauro
authors.forename: C
authors.initials: C
authors.lastname: Fraulini
authors.forename: G M
authors.initials: GM
authors.lastname: Rigolin
authors.forename: R
authors.initials: R
authors.lastname: Galeotti
authors.forename: R
authors.initials: R
authors.lastname: Spanedda
authors.forename: G
authors.initials: G
authors.lastname: Castoldi
mesh_terms: D000368:Aged; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007801:Langerhans Cells / Q000378:metabolism / Q000473:pathology; D013792:Thalidomide / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha; D013792:Thalidomide