title: Diabetic mastopathy in type II diabetes mellitus.
abstract: Diabetic mastopathy can mimic cancer. We report 2 cases of diabetic mastopathy in patients with long-standing type II diabetes. One was insulin-dependent, and the other had never been treated with insulin. These 2 patients had classical acoustical shadow on ultrasonograms. Breast core biopsies showed constellations of morphological features resembling diabetic mastopathy, including sclerotic changes of the fibrous stroma with keloid-like collagen fibers, few epithelioid fibroblasts, perivascular and interlobular mononuclear cell infiltrates, and focal atrophic changes of the ductal-lobular units. Both patients were free of malignancy at 3 and 4 years of follow-up, respectively. There are limited data on diabetic mastopathy in insulin-naive type II diabetes mellitus patients. Better awareness of this entity and its sonographic features may allow more patients to be spared from excisional biopsy.
authors.affiliation: Department of Pathology, Sun Yat-Sen Cancer Center, Taipei, Taiwan.
authors.forename: Jeffrey S H
authors.initials: JS
authors.lastname: Tsung
authors.forename: Teh Y
authors.initials: TY
authors.lastname: Wang
authors.forename: Christopher K Z
authors.initials: CK
authors.lastname: Lin
mesh_terms: D000368:Aged; D001706:Biopsy; D001940:Breast / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged