title: Localized nodular vasculitis: a new variant of localized cutaneous polyarteritis nodosa?
abstract: Cutaneous polyarteritis nodosa (PAN) was first described by Lindberg in 1931. This initial description was followed by many case reports and series, including those of Díaz-Pérez and Winkelmann, who used a strict definition based on cutaneous involvement, and Chen and Daoud who classified the condition into three well differentiated groups. The cutaneous form of PAN is distinct from the systemic form due to its chronic, recurrent, benign nature, the absence of internal organ involvement, and the presence of inflammation in medium and small vessels of the deep dermis and panniculus. In the present article we report our findings for 12 patients with a variant of cutaneous PAN consisting of painful erythematous nodular lesions not preceded or followed by livedo reticularis, that were located exclusively on the lower third of the legs and responded slowly to treatment with corticosteroids and immunosuppressants.
authors.affiliation: Rheumatology Unit, School of Medicine, National University of Colombia, Bogotá, Colombia.
authors.forename: G
authors.initials: G
authors.lastname: Quintana
authors.forename: E L
authors.initials: EL
authors.lastname: Matteson
authors.forename: A
authors.initials: A
authors.lastname: Fernández
authors.forename: J F
authors.initials: JF
authors.lastname: Restrepo
authors.forename: A
authors.initials: A
authors.lastname: Iglesias
mesh_terms: D000293:Adolescent; D000328:Adult; D001158:Arteries / Q000473:pathology; D001379:Azathioprine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007866:Leg; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000098:blood supply / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone; D008727:Methotrexate