title: Opioid receptors and heart resistance to arrhythmogenic factors.
abstract: We present detailed data on the role of central and peripheral opioid receptors in the regulation of heart resistance to arrhythmogenic factors. Stimulation of peripheral delta2- and kappa1-receptors increases heart resistance to the arrhythmogenic effect of acute ischemia and reperfusion. Activation of peripheral mu- and delta1-opioid receptors improves electrical stability of the heart in animals with postinfarction cardiosclerosis. Possible mechanisms for opioidergic regulation of heart resistance to arrhythmogenic factors are discussed.
authors.affiliation: Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
authors.forename: Yu B
authors.initials: YB
authors.lastname: Lishmanov
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
mesh_terms: D000157:Aconitine / Q000494:pharmacology; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D002122:Calcium Chloride / Q000494:pharmacology; D002395:Catecholamines / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D018847:Opioid Peptides / Q000502:physiology; D051381:Rats; D011957:Receptors, Opioid / Q000502:physiology*
chemical_list: D002395:Catecholamines; D018847:Opioid Peptides; D011957:Receptors, Opioid; D002122:Calcium Chloride; D000157:Aconitine