Intestinal parasitic infections and eosinophilia in an human immunedeficiency virus positive population in Honduras.
The occurrence of intestinal parasites, their regional distribution and their relations to eosinophilia were studied in 133 human immunodeficiency virus (HIV) positive individuals from Honduras. After signing an informed consent, participants answered a socio-demographic and risk factor questionnaire, a complete physical examination, medical history, and a series of laboratory tests. All participants were HIV positive but not acquired immunodeficiency syndrome positive. Of them, 67% were co-infected with pathogen and non pathogen parasites. Overall occurrence of nematodes was: 44.3% for Trichuris trichiura, 24% for Ascaris lumbricoides, 12% for Hookworm and 7.5% for Strongyloides stercoralis. No cases of Giardia lamblia, acute amebiasis or cryptosporidiasis were diagnosed. Mean eosinophil percents for participants were consistently and significantly higher in infected than in non infected individuals: 22% for Hookworm vs 7.2% (p < 0.001), 11% for Trichuris compared to 5.2% (p < 0.001), 13.2% compared to 7.5% for S. stercoralis (p < 0.05), and 12% compared to 6% for Ascaris cases (p < 0.05). Helminths and non pathogenic protozoa, as single or mixed infections, occurred among the participants. There was a strong correlation between eosinophilia and helminthiasis infections; however, none was identified between CD4 levels and eosinophilia. Because parasitic infections aggravate malnutrition and promote a disbalanced Th2 response in a potentially immuno-compromised host, their effect on HIV disease progression needs further study, mainly in countries were HIV and parasitic infections are highly prevalent.
Kaminsky
Rina G
RG
Dirección de Investigación Científica, Universidad Nacional Autónoma de Honduras y Hospital-Escuela, Casilla Postal 1587, Tegucigalpa, Honduras. fundar@cablecolor.hn
Soto
Ramón J
RJ
Campa
Adriana
A
Baum
Marianna K
MK
D000293:Adolescent; D000328:Adult; D000818:Animals; D003430:Cross-Sectional Studies; D004802:Eosinophilia / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006679:HIV Seropositivity / Q000150:complications* / Q000453:epidemiology; D006721:Honduras / Q000453:epidemiology; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires