Commonly used drugs impair oral tolerance in mice.
Ibuprofen and antibiotics are commonly prescribed during early childhood. When given to mice at the time at which oral tolerance is induced, both treatments affect either the induction or the maintenance of oral tolerance. These results suggest that the coadministration of these and similarly acting drugs should be considered cautiously for infants at risk of allergy.
Pecquet
Sophie
S
Food Immunology, Nestlé Research Center, BP44, CH 1000 Lausanne 26, Switzerland. sophie.pecquet@rdls.nestle.com
Prioult
Guénolée
G
Campbell
John
J
German
Bruce
B
Turini
Marco
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002675:Child, Preschool; D015232:Dinoprostone / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D007108:Immune Tolerance / Q000187:drug effects / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D051379:Mice; D008807:Mice, Inbred BALB C
D000900:Anti-Bacterial Agents; D007073:Immunoglobulin E; D015232:Dinoprostone; D007052:Ibuprofen