Low ionic strength promotes association of circulating modified LDL in human blood.
The resistance to association of circulating multiply-modified low-density lipoproteins (LDL) isolated from human blood and characterized by a decreased content of sialic acids in comparison with native LDL was studied by analysing light transmission fluctuations. LDL association was stimulated by decreasing environmental ionic strength. It is established that circulating modified LDL are less resistant to association than native LDL. Association of LDL in a medium with low ionic strength was irreversible. Probably, increased capacity to irreversible association determines the atherogenic properties of circulating modified LDL subfraction.
Panasenko
O M
OM
Laboratory of Atherogenic Mechanisms, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Ministry of Health, Moscow, Russia. oleg-panasenko@newmail.ru
Suprun
I V
IV
Mel'nichenko
A A
AA
Sobenin
I A
IA
Orekhov
A N
AN
D001161:Arteriosclerosis / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry* / Q000378:metabolism; D009994:Osmolar Concentration; D012794:Sialic Acids / Q000032:analysis
D008077:Lipoproteins, LDL; D012794:Sialic Acids