A multidimensional model of obsessive-compulsive disorder.
OBJECTIVE
Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition. This heterogeneity can reduce the power and obscure the findings from natural history studies to genome scans, neuroimaging, and clinical trials. The authors review the evidence supporting a multidimensional model of OCD.


METHODS
Computerized and manual literature searches were performed to identify factor-analytic studies of obsessive-compulsive symptoms before data from disciplines that bear on the potential usefulness of these dimensions were considered. Selection criteria included the novelty and importance of studies and their relevance to outcomes of interest to well-informed mental health professionals.


RESULTS
Twelve factor-analytic studies involving more than 2,000 patients were identified that consistently extracted at least four symptom dimensions: symmetry/ordering, hoarding, contamination/cleaning, and obsessions/checking. These dimensions were associated with distinct patterns of comorbidity, genetic transmission, neural substrates, and treatment response. The evidence supporting the hoarding dimension is particularly robust.


CONCLUSIONS
The complex clinical presentation of OCD can be summarized with a few consistent, temporally stable symptom dimensions. These can be understood as a spectrum of potentially overlapping syndromes that may 1) coexist in any patient, 2) be continuous with normal obsessive-compulsive phenomena, and 3) extend beyond the traditional nosological boundaries of OCD. Although the dimensional structure of obsessive-compulsive symptoms is imperfect, this quantitative approach to phenotypic traits has the potential to advance our understanding of OCD and may aid in the identification of more robust endophenotypes. The need for a dimensional rating scale and suggestions for future research aimed at reducing the burden of this disorder are discussed.
Mataix-Cols
David
D
Institute of Psychiatry, London.
Rosario-Campos
Maria Conceição do
MC
Leckman
James F
JF
D001921:Brain / Q000503:physiopathology; D015928:Cognitive Behavioral Therapy; D003952:Diagnostic Imaging / Q000706:statistics & numerical data; D005163:Factor Analysis, Statistical; D020022:Genetic Predisposition to Disease; D006801:Humans; D008959:Models, Neurological; D008960:Models, Psychological; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology*; D010555:Personality Inventory / Q000706:statistics & numerical data; D010641:Phenotype; D011237:Predictive Value of Tests; D025341:Principal Component Analysis; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
D017367:Selective Serotonin Reuptake Inhibitors