Characterization of apoptosis induced by fucoxanthin in human promyelocytic leukemia cells.
Apoptosis induced by fucoxanthin in HL-60 cells was associated with a loss of mitochondrial membrane potential at an early stage, but not with an increase in reactive oxygen species. Fucoxanthin treatment caused cleavages of procaspase-3 and poly (ADP-ribose) polymerase without any effect on the protein level of Bcl-2, Bcl-X(L), or Bax. Apoptosis induction by fucoxanthin may be mediated via mitochondrial membrane permeabilization and caspase-3 activation.
Kotake-Nara
Eiichi
E
National Food Research Institute, Ibaraki, Japan.
Terasaki
Masaru
M
Nagao
Akihiko
A
D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D006801:Humans; D007425:Intracellular Membranes / Q000187:drug effects; D015473:Leukemia, Promyelocytic, Acute; D008928:Mitochondria / Q000187:drug effects; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D017382:Reactive Oxygen Species; D024341:Xanthophylls / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; D017382:Reactive Oxygen Species; D024341:Xanthophylls; C025164:fucoxanthin; D011065:Poly(ADP-ribose) Polymerases; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases