title: Microbiological profile of community-acquired pneumonia in adults over the last 20 years.
abstract: OBJECTIVE
  To assess any change in the microbiological profile of community-acquired pneumonia (CAP) in our region over the last 20 years.
  
  
  METHODS
  We compared hospital admissions aged between 15 and 74 (n = 61) in Norfolk (UK) for CAP over a 19-month period in 1982-3 (ST1) with all admissions aged over 16 (n = 99) over a 14-month period in 1999-2000 (ST2). Data were collected for ST1 as part of a prospective multicentred research study, in a period of high Mycoplasma pneumoniae activity. ST2 was a prospective study of clinical practice. Chlamydophila species were differentiated in ST2 using whole-cell immunofluorescence.
  
  
  RESULTS
  A microbiological diagnosis was made in 38 (62%) in ST1 compared with 48 (48%) in ST2. Streptococcus pneumoniae remained the most common pathogen (26% in ST1, 25% in ST2). The incidence of M. pneumoniae was 18% in ST1 and 4% in ST2. The proportion of viral pathogens identified was similar: nine (15%) in ST1 and 14 (14%) in ST2. No cases of Chlamydophila pneumoniae were diagnosed in ST2.
  
  
  CONCLUSIONS
  The microbiological profile of CAP in Norfolk (UK) has not changed over the last 20 years and C. pneumoniae is not a frequent pathogen.
authors.affiliation: Department of Respiratory Medicine, Norfolk and Norwich University Hospital, Colney Lane, Norwich, Norfolk NR4 7UY, UK. luke.howard@tinyworld.co.uk
authors.forename: L S G E
authors.initials: LS
authors.lastname: Howard
authors.forename: M
authors.initials: M
authors.lastname: Sillis
authors.forename: M C
authors.initials: MC
authors.lastname: Pasteur
authors.forename: A V
authors.initials: AV
authors.lastname: Kamath
authors.forename: B D W
authors.initials: BD
authors.lastname: Harrison
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D023501:Chlamydophila / Q000302:isolation & purification; D017714:Community-Acquired Infections / Q000382:microbiology*; D006801:Humans; D008875:Middle Aged; D009177:Mycoplasma pneumoniae / Q000302:isolation & purification; D018410:Pneumonia, Bacterial / Q000382:microbiology*; D011024:Pneumonia, Viral / Q000382:microbiology*; D011446:Prospective Studies; D013296:Streptococcus pneumoniae / Q000302:isolation & purification