[Early signals of systemic mycoses--guidelines for therapeutic decisions?].
Clinical applications and in vitro studies show that all antimycotics are most effective against infection when applied as early as possible. An early diagnosis is, therefore, essential. At this time for aspergillosis and particularly candidosis, a statement is only possible by combining several diagnostic methods. Inflammatory parameters like procalcitonin, C-reactive protein and proinflammatory cytokines are most important evidence of infection. Antigen tests are more significant by higher sensitivity. Attention should be focused on the detection of mannan by ELISA test, beta-glucan and D-arabinitol. Given the present research level in the field of proteomics, the diagnostic importance of transmembranal receptor proteins or other regulatory proteins seems promising.
Bernhardt
H
H
Medizinische Fakultät der Ernst-Moritz-Arndt-Universität Greifswald, Apfelweg 4a, D-17489 Greifswald, Germany. dmykbern@uni-greifswald.de
Knoke
M
M
D000935:Antifungal Agents / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D002116:Calcitonin / Q000032:analysis; D016207:Cytokines / Q000032:analysis; D042241:Early Diagnosis; D008351:Mannans / Q000032:analysis; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy*; D011498:Protein Precursors / Q000032:analysis; D013402:Sugar Alcohols / Q000032:analysis; D047071:beta-Glucans / Q000032:analysis
D000935:Antifungal Agents; D000946:Antigens, Fungal; D016207:Cytokines; D008351:Mannans; D011498:Protein Precursors; D013402:Sugar Alcohols; D047071:beta-Glucans; D002116:Calcitonin; D002097:C-Reactive Protein; C014999:arabitol