Lack of depression effect on platelet activation in patients with heart failure.
P-selectin is a marker of platelet activation. Previous studies have reported elevated P-selectin in patients with congestive heart failure (CHF) and depression as separate disorders. We examined if comorbid depression had an effect on platelet activation in CHF patients. Soluble (s)P-selectin was measured in 108 CHF patients; 24 with comorbid depression. There were no significant differences in age, cardiac parameters or (s)P-selectin levels between CHF-only patients and patients with comorbid depression. Our data show no group differences in P-selectin values, which suggests that comorbid depression has no additive effect on platelet activation in CHF patient.
Pasic
Jagoda
J
Department of Psychiatry and Behavioral Sciences, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Box 350896, Seattle, WA 98104-2499, USA. jpasic@u.washington.edu
Sullivan
Mark D
MD
Russo
Joan
J
Chandler
Wayne L
WL
Levy
Wayne C
WC
D015897:Comorbidity; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D015539:Platelet Activation / Q000502:physiology*
D019007:P-Selectin