title: Expression of IFITM1 in chronic myeloid leukemia patients.
abstract: We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 x 10(-11)) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival.
authors.affiliation: Department of Molecular Biology and Genetics, Bilkent University, Bilkent, 06800 Ankara, Turkey.
authors.forename: Cemaliye Boylu
authors.initials: CB
authors.lastname: Akyerli
authors.forename: Meral
authors.initials: M
authors.lastname: Beksac
authors.forename: Michelle
authors.initials: M
authors.lastname: Holko
authors.forename: Mathias
authors.initials: M
authors.lastname: Frevel
authors.forename: Klara
authors.initials: K
authors.lastname: Dalva
authors.forename: Uğur
authors.initials: U
authors.lastname: Ozbek
authors.forename: Ender
authors.initials: E
authors.lastname: Soydan
authors.forename: Muhit
authors.initials: M
authors.lastname: Ozcan
authors.forename: Gülsüm
authors.initials: G
authors.lastname: Ozet
authors.forename: Osman
authors.initials: O
authors.lastname: Ilhan
authors.forename: Günhan
authors.initials: G
authors.lastname: Gürman
authors.forename: Hamdi
authors.initials: H
authors.lastname: Akan
authors.forename: Bryan R G
authors.initials: BR
authors.lastname: Williams
authors.forename: Tayfun
authors.initials: T
authors.lastname: Ozçelik
mesh_terms: D000328:Adult; D000368:Aged; D000943:Antigens, Differentiation; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000145:classification / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016019:Survival Analysis
chemical_list: D000943:Antigens, Differentiation; D014408:Biomarkers, Tumor; D008565:Membrane Proteins; C062010:leu-13 antigen