title: [Kikuchi-Fujimoto disease: histiocytic necrotising lymphadenitis].
abstract: BACKGROUND
  Kikuchi-Fujimoto disease or necrotizing histiocyte lymphadenitis is a disease of unknown cause whose main clinical feature is adenopathy, generally in a cervical location. The disease was described for the first time in Japan in 1972 and the first case in France was reported in 1986. Clinicians should be aware of this uncommon disease in order to differentiate it from infectious adenitis, lymphoma and collagenosis.
  
  
  METHODS
  A 21-year-old woman consulted the emergency physician in January 2002 for a right cervical mass which had developed rapidly with no associated symptom. Other smaller masses developed within the following days. Laboratory results demonstrated discrete inflammation. All serologies tested were normal. Diagnostic cervicotomy was performed. The histological diagnosis was necrotizing adenitis.
  
  
  CONCLUSIONS
  Necrotizing histiocyte lymphadenitis is generally observed in young women in their twenties. There has been no predominant ethnic background. Laboratory tests are normal excepting for discrete signs of inflammation. Diagnosis is provided by pathology and immunohistochemistry. The clinical course is generally spontaneously favorable in six months. Relapse is uncommon.
authors.affiliation: Service de Chirurgie Maxillo-faciale et de Stomatologie, Centre hospitalier intercommunal, 40 allée de la Source, 94195 Villeneuve-Saint-Georges Cedex. gtoure@voila.fr
authors.forename: G
authors.initials: G
authors.lastname: Touré
authors.forename: A-M
authors.initials: AM
authors.lastname: Roucayrol
authors.forename: J-P
authors.initials: JP
authors.lastname: Meningaud
mesh_terms: D000328:Adult; D018414:CD8-Positive T-Lymphocytes; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D009333:Neck