MPP+: mechanism for its toxicity in cerebellar granule cells.
Cerebellar granule cells constitute the largest homogeneous neuronal population of the mammalian brain. However, they are not often used in studies that involve MPP+-neurotoxicity. Currently, it is known that the toxicity of MPP+ in cerebellar granule cells as well as in other models, including dopaminergic cells, results from activation of the apoptotic machinery after an initial oxidative burst with mitochondrial damage and energetic failure. Therefore, cerebellar granule cells serve as a good model to investigate the MPP+ effects and to study in vitro the molecular mechanism implicated in the genesis of Parkinson's disease.
González-Polo
Rosa A
RA
Departamento de Bioquímica y Biología Molecular y Genética, E.U. Enfermería y T.O., Universidad de Extremadura, Cáceres, Spain.
Soler
Germán
G
Fuentes
José M
JM
D015655:1-Methyl-4-phenylpyridinium / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology
D015655:1-Methyl-4-phenylpyridinium