title: Effect of a nutritive-tonic drink on stress-induced serum glucocorticoid in the mouse.
abstract: We evaluated stress during "restraint with gnawing (R+G+)" and "restraint without gnawing (R+G-)" in a mouse system. R+G- induced a higher serum glucocorticoid level than R+G+. Zena F-III (a nutritive-tonic drink prescribed as "Kampo", a traditional Japanese medicine with its origin in Chinese medicine) reduced the glucocorticoid elevation in R+G+, but not in R+G-. These results support the hypotheses that (i) activity, such as gnawing, which potentially leading to escape from distress, reduces the severity of emotional distress and (ii) Zena F-III reduces the severity of mental or emotional fatigue, or increases motivation, in a stressful situation that the animal can manage itself.
authors.affiliation: Department of Pharmacological Evaluation Laboratory, Self Medication Laboratory, Taisho Pharmaceutical Co Ltd, Saitama 330-8530, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Sakata
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ayada
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Ito
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tadano
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Endo
mesh_terms: D000818:Animals; D001628:Beverages; D001835:Body Weight; D004195:Disease Models, Animal; D005938:Glucocorticoids / Q000097:blood*; D007564:Japan; D007700:Kinetics; D008297:Male; D020835:Medicine, Kampo; D051379:Mice; D008807:Mice, Inbred BALB C; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000097:blood* / Q000628:therapy*
chemical_list: D005938:Glucocorticoids