Hantaviruses: immunology, treatment, and prevention.
Hantaviruses are rodent-borne bunyaviruses that are associated with two main clinical diseases in humans: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. It has been suggested that host-related immune mechanisms rather than direct viral cytopathology may be responsible for the principal abnormality (vascular dysfunction) in these syndromes. This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.
Maes
Piet
P
Laboratory of Clinical Virology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
Clement
Jan
J
Gavrilovskaya
Irina
I
Van Ranst
Marc
M
D000595:Amino Acid Sequence; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D015195:Drug Design; D006476:Orthohantavirus / Q000145:classification / Q000276:immunology / Q000472:pathogenicity; D018778:Hantavirus Infections / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D018804:Hantavirus Pulmonary Syndrome / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D014765:Viral Vaccines
D000998:Antiviral Agents; D014765:Viral Vaccines