title: Not just another hole in the wall: understanding intercellular protein trafficking.
abstract: Development and differentiation of multicellular organisms requires cell-to-cell communication. In plants direct signaling and exchange of macromolecules between cells is possible through plasmodesmata. Recently direct exchange of membrane-bound vesicles and organelles has been demonstrated between animal cells through formation of cytoplasmic bridges (tunneling nanotubes) in vitro. Here we review recent developments in cell-to-cell trafficking of macromolecules in plants and animals.
authors.affiliation: Department of Biology, Duke University, Durham, NC 27708, USA.
authors.forename: Kimberly L
authors.initials: KL
authors.lastname: Gallagher
authors.forename: Philip N
authors.initials: PN
authors.lastname: Benfey
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D046911:Macromolecular Substances / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism; D010944:Plants / Q000378:metabolism; D031425:Plasmodesmata / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology
chemical_list: D046911:Macromolecular Substances; D010940:Plant Proteins