Alternative splicing regulation impacts heart development.
SR proteins serve multiple roles in the posttranscriptional control of gene expression, including as regulators of alternative splicing. In this issue of Cell, Xu et al. (2005) demonstrate that a heart-specific knockout of one SR protein, ASF/SF2, produces cardiomyopathy and misregulation of specific alternative splicing events during early postnatal development.
Cooper
Thomas A
TA
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA.
D017398:Alternative Splicing; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology* / Q000503:physiopathology; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins; D000068103:Serine-Arginine Splicing Factors
D009687:Nuclear Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D000068103:Serine-Arginine Splicing Factors