Activity of a paromomycin hydrophilic formulation for topical treatment of infections by Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis.
Studies on in vitro skin permeation and in vivo anti-leishmanial activity in mice experimentally infected with Leishmania (Leishmania) major pointed out to the potential of a new paromomycin (PA) formulation (hydrophilic gel) for treatment of cutaneous leishmaniasis (CL). In this study, the activity of this formulation was evaluated in animals experimentally infected by Leishmania species that prevail in the New World. PA gel activity was compared to antimony treatment, since it is still the first choice treatment to the different clinical forms of leishmaniasis. The topical treatment activity with 10% PA gel in BALB/c mice infected by Leishmania (Leishmania) amazonensis was higher than that observed for parenteral antimony treatment, while the efficacy of these two regimes in hamsters infected by Leishmania (Viannia) braziliensis was similar. These results suggest that this formulation could be suitable for clinical studies and may represent an alternative novel formulation for topical treatment of CL.
Gonçalves
Gisele Santos
GS
Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais (UFMG), Av Antônio Carlos, 6627, CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.
Fernandes
Ana Paula
AP
Souza
Renata Celi Carvalho
RC
Cardoso
Jarbas Eustáquio
JE
de Oliveira-Silva
Fernanda
F
Maciel
Fabiana Cristina
FC
Rabello
Ana
A
Ferreira
Lucas Antônio Miranda
LA
D000287:Administration, Topical; D000818:Animals; D000967:Antimony Sodium Gluconate / Q000494:pharmacology; D006224:Cricetinae; D005260:Female; D005782:Gels; D007273:Injections, Intramuscular; D007892:Leishmania braziliensis; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008536:Meglumine / Q000494:pharmacology; D000077485:Meglumine Antimoniate; D051379:Mice; D008807:Mice, Inbred BALB C; D009942:Organometallic Compounds / Q000494:pharmacology; D010303:Paromomycin / Q000494:pharmacology*; D011897:Random Allocation; D018709:Statistics, Nonparametric
D005782:Gels; D009942:Organometallic Compounds; D010303:Paromomycin; D008536:Meglumine; D000077485:Meglumine Antimoniate; D000967:Antimony Sodium Gluconate