title: Chemical constituents of Lychnophora pohlii and trypanocidal activity of crude plant extracts and of isolated compounds.
abstract: Crude extracts of Lychnophora pohlii were tested in vitro against trypomastigote forms of Trypanosoma cruzi, and the dichloromethane and methanol crude extracts from leaves plus inflorescences were found to have trypanocidal activity. The bioassay-guided fractionation of the extracts yielded seven active compounds: the sesquiterpene lactones lychnopholide, centratherin, goyazensolide and 15-desoxygoyazensolide in the dichloromethane extract, and caffeic acid and the flavonoids luteolin and vicenin-2 in the methanol extract. One active caffeoyl quinic acid derivative was isolated from the inactive hydroalcoholic extract of leaves plus inflorescences. Chemically, the plant has sesquiterpene lactone type furanoheliangolides, flavonoids, caffeic acid, a caffeoyl quinic acid derivative, which are characteristic of the Vernonieae.
authors.affiliation: Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café s/n, 14040-903, Ribeirão Preto-SP, Brazil.
authors.forename: C F F
authors.initials: CF
authors.lastname: Grael
authors.forename: S
authors.initials: S
authors.lastname: Albuquerque
authors.forename: J L C
authors.initials: JL
authors.lastname: Lopes
mesh_terms: D000818:Animals; D019659:Asteraceae; D014355:Chagas Disease / Q000188:drug therapy / Q000469:parasitology; D006801:Humans; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D014344:Trypanocidal Agents