title: Morphological and immunohistochemical features of tumor infiltrating lymphocytes (TIL) in carcinomas. Note I.
abstract: Some malignant tumours like testicular seminomas and ovarian dysgerminomas or medullar carcinoma of the breast, present an unusually lympho-histiocytic (TIL) rich stroma. Many reports have concluded that the prognosis for these patients is correlated with the intensity of TIL. Recently, some analyses consider that tumour-host interactions have a significant prognostic role in many other neoplasms. The presence of TIL may be a sign of less aggressive behaviour of some epithelial neoplasm like gastro-intestinal, pulmonary, mammary, urinary or cutaneous carcinomas (Wilson et al.). The aim of this study is a morphological and immunohistochemical (IHC) characterisation of the lympho-histiocytic populations of TIL in some gastro-intestinal and mammary carcinomas. The two localisation were chosen for their different contact with the exogene antigens and their possible different type of host's immune response.
authors.affiliation: Department of Pathology, V. Babeş Institute, Bucharest.
authors.forename: C
authors.initials: C
authors.lastname: Ardeleanu
authors.forename: F
authors.initials: F
authors.lastname: Hălălău
authors.forename: L
authors.initials: L
authors.lastname: Benea
authors.forename: G
authors.initials: G
authors.lastname: Butur
authors.forename: N
authors.initials: N
authors.lastname: Nicolau
authors.forename: E
authors.initials: E
authors.lastname: Nicolaescu
authors.forename: F
authors.initials: F
authors.lastname: Stăniceanu
authors.forename: S
authors.initials: S
authors.lastname: Zurac
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D018951:Antigens, CD20 / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D044584:Carcinoma, Ductal / Q000378:metabolism / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D017493:Leukocyte Common Antigens / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000378:metabolism / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating / Q000378:metabolism / Q000473:pathology*; D046529:Microscopy, Electron, Transmission; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D018951:Antigens, CD20; D017493:Leukocyte Common Antigens