title: The Icm/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetii.
abstract: Type-IV secretion systems are devices present in a wide range of bacteria (including bacterial pathogens) that deliver macromolecules (proteins and single-strand-DNA) across kingdom barriers (as well as between bacteria and into the surroundings). The type-IV secretion systems were divided into two subgroups and Legionella pneumophila and Coxiella burnetii are the only two bacteria known today to utilize a type-IVB secretion system for pathogenesis. In this review we summarized the available information concerning the icm/dot type-IVB secretion systems by comparing the two bacteria that possess this system, the proteins components of their systems as well as the homology of proteins from type-IVB secretion systems to proteins from type-IVA secretion systems. In addition, the phenotypes associated with mutants in the L. pneumophila icm/dot genes, their relations to properties of specific Icm/Dot proteins as well as the protein substrates delivered by this system are described.
authors.affiliation: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv, Tel-Aviv 69978, Israel. gils@tauex.tau.ac.il
authors.forename: Gil
authors.initials: G
authors.lastname: Segal
authors.forename: Michal
authors.initials: M
authors.lastname: Feldman
authors.forename: Tal
authors.initials: T
authors.lastname: Zusman
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D016997:Coxiella burnetii / Q000235:genetics* / Q000378:metabolism* / Q000472:pathogenicity; D016952:Legionella pneumophila / Q000235:genetics* / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
chemical_list: D001426:Bacterial Proteins