title: How common is delayed cyclosporine absorption following liver transplantation?
abstract: The mean time to peak absorption of cyclosporine (CsA) in liver transplant patients is approximately 2 hours, but in some patients the peak occurs later. The goal of this study was, therefore, to investigate the incidence of delayed absorption in 27 de novo liver transplant recipients receiving CsA > or =10 mg/kg/day (C(2) monitoring) and in 15 maintenance patients. Patients were categorized as 'normal' absorbers (C(2) exceeding C(4) and C(6)) or 'delayed' absorbers (C(4) or C(6) exceeding C(2)), and as 'good' (>800 ng/mL at C(0), C(2), C(4), or C(6)) or 'poor' absorbers (C(0), C(2), C(4) and C(6) <800 ng/mL) on the day of study. Among de novo patients, 15 (56%) had 'normal' CsA absorption and 12 (44%) 'delayed' absorption. Good CsA absorption occurred in 16 patients (59%) and poor absorption in 11 (41%). The proportion of poor absorbers was similar in patients with normal (6/15, 40%) or delayed (5/12, 42%) absorption. Among the 12 delayed absorbers, 11 had peak CsA concentration at C(4). Mean C(0) level was significantly higher in delayed absorbers (282 +/- 96 ng/mL) than in normal absorbers (185 +/- 88 ng/mL; P = .01). Delayed absorbers reverted to normal absorption (C(2) > C(4)) after a median of 6 days from the day of study, and no cases of delayed absorption were found among maintenance patients. In conclusion, almost 50% of the patients had delayed CsA absorption early posttransplant; around half of these exhibited normal CsA exposure. Measurement of C(4) in addition to C(2) differentiates effectively between delayed and poor absorbers of CsA such that over- or underimmunosuppression can be avoided.
authors.affiliation: Liver Unit, Fundación Favaloro, Buenos Aires, Argentina.
authors.forename: Silvina E
authors.initials: SE
authors.lastname: Yantorno
authors.forename: Eva B
authors.initials: EB
authors.lastname: Varela
authors.forename: Sebastián R
authors.initials: SR
authors.lastname: Raffa
authors.forename: Valeria I
authors.initials: VI
authors.lastname: Descalzi
authors.forename: Maria L
authors.initials: ML
authors.lastname: Gomez Carretero
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Pirola
authors.forename: Andres E
authors.initials: AE
authors.lastname: Ruf
authors.forename: Gretel I
authors.initials: GI
authors.lastname: Martinez Carabuz
authors.forename: Luis G
authors.initials: LG
authors.lastname: Podesta
authors.forename: Federico G
authors.initials: FG
authors.lastname: Villamil
mesh_terms: D000328:Adult; D000368:Aged; D003524:Cyclosporins / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D003524:Cyclosporins; D007166:Immunosuppressive Agents