title: Does substitution of T4 with T3 plus T4 for T4 replacement improve depressive symptoms in patients with hypothyroidism?
abstract: Substitution of T4 with T3 for T4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. Forty individuals were included who had depressive symptoms on stable doses of levothyroxine. Combined T4 plus T3 did not have a significantly different effect on mood and well-being scores than did T4 alone.
authors.affiliation: Department of Psychiatry, UMDNJ, New Jersey Medical School, Newark, NJ 07103, USA. joffe@umdnj.edu
authors.forename: Russell T
authors.initials: RT
authors.lastname: Joffe
authors.forename: Anna M
authors.initials: AM
authors.lastname: Sawka
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Marriott
authors.forename: Glenda M
authors.initials: GM
authors.lastname: MacQueen
authors.forename: Hertzl C
authors.initials: HC
authors.lastname: Gernstein
mesh_terms: D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology*; D004359:Drug Therapy, Combination; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use*; D014284:Triiodothyronine / Q000627:therapeutic use*
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine