The total synthesis of gambierol.
This communication describes the total synthesis of the marine polyether toxin, gambierol. This work couples our iterative C-glycoside/enol ether-olefin metathesis strategy to the subunits with a unique olefin metathesis/carbonyl olefination reaction to bring the subunits together.
Johnson
Henry W B
HW
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
Majumder
Utpal
U
Rainier
Jon D
JD
D000818:Animals; D002922:Ciguatoxins / Q000138:chemical synthesis*; D004141:Dinoflagellida / Q000737:chemistry; D004988:Ethers, Cyclic / Q000138:chemical synthesis*; D006027:Glycosides / Q000737:chemistry; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D035964:Oxocins
D002922:Ciguatoxins; D004988:Ethers, Cyclic; D006027:Glycosides; D011083:Polycyclic Compounds; C435770:gambierol; D035964:Oxocins