Olanzapine-induced diabetes in a seven-year-old boy.
The atypical antipsychotics have been recognized to induce diabetes mellitus and ketoacidosis in the adult psychiatric population. This report notes the onset of weight gain, diabetes, and apparent ketosis in a prepubertal boy diagnosed with bipolar disorder and treated with olanzapine. The hyperglycemia rapidly normalized after discontinuation of the olanzapine. Within 2 years, the diabetes recurred. In spite of the normalization of blood-glucose levels, urine ketone tests remained positive and were explained by the fact that patients taking valproic acid may have a false-positive urine test for ketones. Regular monitoring of glucose should be considered in children and adolescents who gain weight while treated with atypical antipsychotics.
Courvoisie
Helen E
HE
Division of Child and Adolescent Psychiatry Division, Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, MD 21287-3325, USA. hcourvoi@jhmi.ed
Cooke
David W
DW
Riddle
Mark A
MA
D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy*; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced*; D006801:Humans; D008297:Male; D000077152:Olanzapine; D012008:Recurrence
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine