title: Effect of hyperhomocysteinemia induced by methionine administration on flow-mediated dilatation of the brachial artery in healthy subjects.
abstract: Homocysteine may contribute to systolic hypertension and cardiac events by decreasing conduit artery compliance and inducing endothelial dysfunction. The effects of the experimental induction of hyperhomocysteinemia on systemic arterial compliance and pulsewave velocity are unclear, with contradictory results from previous studies. The investigators tested whether oral methionine impairs brachial artery compliance in addition to endothelial function.
authors.affiliation: Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
authors.forename: Moutasim H
authors.initials: MH
authors.lastname: Al-Shaer
authors.forename: Geetha
authors.initials: G
authors.lastname: Raghuveer
authors.forename: Roger
authors.initials: R
authors.lastname: Browning
authors.forename: Christine A
authors.initials: CA
authors.lastname: Sinkey
authors.forename: Catherine
authors.initials: C
authors.lastname: Chenard
authors.forename: Phyllis
authors.initials: P
authors.lastname: Stumbo
authors.forename: William G
authors.initials: WG
authors.lastname: Haynes
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000139:chemically induced*; D016014:Linear Models; D008297:Male; D008715:Methionine / Q000008:administration & dosage / Q000494:pharmacology*; D018608:Ultrasonography, Doppler
chemical_list: D008715:Methionine