Chronic Burkholderia multivorans bronchial infection in a non-cystic fibrosis individual with mannose binding lectin deficiency.
The case history is presented of a woman with multiple respiratory infections and mannose binding lectin (MBL) deficiency but no evidence of bronchiectasis who developed a chronic Burkholderia multivorans infection. Careful microbiological assessment is needed in patients with recurrent respiratory infection and the presence of B multivorans should trigger further immunological investigation including assessment of MBL status.
Whitehouse
J L
JL
Lung Defence Clinic, Papworth Hospital, Papworth St Everard, Cambridgeshire CB3 8RE, UK. jo_wh@excite.com
Exley
A R
AR
Foweraker
J
J
Bilton
D
D
D000328:Adult; D019121:Burkholderia Infections / Q000188:drug therapy* / Q000235:genetics; D016956:Burkholderia cepacia / Q000235:genetics*; D002908:Chronic Disease; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D037601:Mannose-Binding Lectin / Q000031:analogs & derivatives* / Q000172:deficiency* / Q000235:genetics; D011110:Polymorphism, Genetic; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology
C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin