Potential and origin of the hematopoietic population in human skeletal muscle.
While mononuclear cells isolated from murine skeletal muscle were shown to be capable of hematopoietic activity, similar hematopoietic cells (HC) recently were reported to exist in primate muscle. We investigated muscle-derived HC from young and adult human subjects. Although hematopoietic stem cells were rare in muscle, their frequency nonetheless was approximately four times greater than in peripheral blood. These cells in muscle appeared to originate from CD45(+) bone marrow cells. Our results suggested an additional function of human skeletal muscle as a reservoir of HC.
Tsuboi
Kosuke
K
Division of Hematology/Oncology, Department of Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Kawada
Hiroshi
H
Toh
Eiren
E
Lee
Yoon Hwan
YH
Tsuma
Mitsuyo
M
Nakamura
Yoshihiko
Y
Sato
Tadayuki
T
Ando
Kiyoshi
K
Mochida
Joji
J
Kato
Shunichi
S
Hotta
Tomomitsu
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology; D019070:Cell Lineage; D002648:Child; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D016130:Immunophenotyping; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008297:Male; D051379:Mice; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000166:cytology*
D017493:Leukocyte Common Antigens