title: Long-term survival in high-grade axial osteosarcoma with bone and lung metastases treated with chemotherapy only.
abstract: A boy, age 2 years 10 months, with high-grade malignant osteosarcoma of the fifth lumbar vertebra with secondary bilateral pulmonary lesions and bone metastasis at the fifth thoracic vertebra is described. The primary site of disease was inoperable and the patient was treated with chemotherapy only. At present, 83 months from diagnosis and 64 from the end of therapy, he is in very good general condition. Although a surgical approach on the primary and secondary sites is fundamental, this case may be considered an indication of the efficacy of aggressive chemotherapy in treating osteosarcoma.
authors.affiliation: Department of Pediatric Oncology, University of Turin, Regina Margherita Children's Hospital, Turin, Italy. adalberto.brachdelprever@unito.it
authors.forename: Adalberto Brach
authors.initials: AB
authors.lastname: del Prever
authors.forename: Franca
authors.initials: F
authors.lastname: Fagioli
authors.forename: Mara
authors.initials: M
authors.lastname: Berta
authors.forename: Franco
authors.initials: F
authors.lastname: Bertoni
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferrari
authors.forename: Mario
authors.initials: M
authors.lastname: Mercuri
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D016190:Carboplatin / Q000008:administration & dosage; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008159:Lumbar Vertebrae / Q000473:pathology*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D012516:Osteosarcoma / Q000188:drug therapy* / Q000556:secondary*; D013904:Thoracic Vertebrae / Q000473:pathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D016190:Carboplatin; D002945:Cisplatin; D007069:Ifosfamide; D008727:Methotrexate