Influenza-associated encephalopathy: no evidence for neuroinvasion by influenza virus nor for reactivation of human herpesvirus 6 or 7.
During 2 consecutive influenza seasons we investigated the presence of influenza virus, human herpesvirus (HHV) type 6, and HHV-7 in cerebrospinal fluid samples from 9 white children suffering from influenza-associated encephalopathy. We conclude that it is unlikely that neuroinvasion by influenza virus or reactivation of either HHV-6 or HHV-7 is involved.
van Zeijl
J H
JH
Department of Medical Microbiology, Public Health Laboratory Friesland, Leeuwarden, The Netherlands. jan.van.zeijl@lvf.nl
Bakkers
J
J
Wilbrink
B
B
Melchers
W J G
WJ
Mullaart
R A
RA
Galama
J M D
JM
D001927:Brain Diseases / Q000209:etiology / Q000821:virology*; D002675:Child, Preschool; D015654:Herpesvirus 6, Human / Q000502:physiology*; D016199:Herpesvirus 7, Human / Q000502:physiology*; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000150:complications*; D009975:Orthomyxoviridae / Q000502:physiology*; D019349:Roseolovirus Infections / Q000150:complications; D014775:Virus Activation