Case-control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population.
The close homolog of L1 (CHL1), located on human chromosome 3p26.1, is a newly identified member of the L1 family of cell adhesion molecules which play important roles in cell migration, axonal growth, and synaptic remodeling. A positive association has been reported between a missense polymorphism in CHL1 gene and schizophrenia in the Japanese population [Sakurai, K., Migita, O., Toru, M., Arinami, T., 2002. An association between a missense polymorphism in the close homologue of L1 (CHL1, CALL) gene and schizophrenia. Mol. Psychiatry 7, 412-415]. An association between a missense polymorphism in the close homologue of L1 (CHL1, CALL) gene and schizophrenia. In order to test this finding, we genotyped four SNPs in the gene in the Han Chinese population using a sample of 560 cases and 576 controls. Analysis of allele frequencies in both samples also showed strong association between SNP rs2272522 (the same marker studied by K. Sakurai) and the disease (X2=31.591, P<0.000001, OR=1.745, 95% CI=1.435-2.121). Our results confirm the positive association between CHL1 gene and schizophrenia and indicate that CHL1 may be involved in the etiology of schizophrenia.
Chen
Qing-Ying
QY
Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, PR China.
Chen
Qi
Q
Feng
Guo-Yin
GY
Lindpaintner
Klaus
K
Chen
Yi
Y
Sun
Xiaodong
X
Chen
Zhengxiong
Z
Gao
Zhensong
Z
Tang
Jisheng
J
He
Lin
L
D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules; D002681:China; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008565:Membrane Proteins; D020125:Mutation, Missense / Q000235:genetics; D039842:Neural Cell Adhesion Molecule L1 / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*
C490650:CHL1 protein, human; D015815:Cell Adhesion Molecules; D017931:DNA Primers; D008565:Membrane Proteins; D039842:Neural Cell Adhesion Molecule L1; D011506:Proteins