title: ent-halimane diterpenes and a guaiane sesquiterpene from Cladogynos orientalis.
abstract: Four new ent-halimane diterpenes (1-4) and one new guaiane sesquiterpene (5) were isolated from the CHCl(3) extract of the roots of Cladogynos orientalis, together with six known compounds. The structures of compounds 1-5 were established using spectroscopic methods, and the stereochemistry of chettaphanin I (6) was confirmed by X-ray crystallography.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Mayuree
authors.initials: M
authors.lastname: Kanlayavattanakul
authors.forename: Nijsiri
authors.initials: N
authors.lastname: Ruangrungsi
authors.forename: Toshiko
authors.initials: T
authors.lastname: Watanabe
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kawahata
authors.forename: Bruno
authors.initials: B
authors.lastname: Therrien
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ishikawa
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D008968:Molecular Conformation; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013785:Thailand; D014407:Tumor Cells, Cultured
chemical_list: C497405:8-hydroxyguaiene; D000972:Antineoplastic Agents, Phytogenic; D000995:Antitubercular Agents; D004224:Diterpenes; D045789:Sesquiterpenes, Guaiane