title: Association between IFNA genotype and the risk of systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is characterized by multisystem inflammation and production of autoantibodies, which can generate immune complexes and may cause tissue damage through the recognition of an autoantigen. Although many factors have been proposed, such as genetic factors, environmental factors, hormonal action, viruses, and dysregulation of cytokine production, the cause of this disease is not well understood. It has been reported that the levels of interferon (IFN)-alpha in the sera of some SLE patients are elevated and that IFN-alpha induces maturation of monocytes into highly active antigen-presenting dendritic cells (DCs). We analyzed the association between IFN-alpha genotype and the risk of SLE to clarify whether IFN-alpha plays a central role in susceptibility to SLE. The results showed that no IFN-alpha genotype was significantly associated with the risk of SLE.
authors.affiliation: Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, 812-8582 Higashi-ku, Fukuoka, Japan. hnakashi@intmed1.med.kyushu-u.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nakashima
authors.forename: Sawako
authors.initials: S
authors.lastname: Matsuno
authors.forename: Mitsuteru
authors.initials: M
authors.lastname: Akahoshi
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Miyake
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Inoue
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ninomiya
authors.forename: Sakiko
authors.initials: S
authors.lastname: Shimizu
authors.forename: Takashi
authors.initials: T
authors.lastname: Igawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sadanaga
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otsuka
authors.forename: Mine
authors.initials: M
authors.lastname: Harada
mesh_terms: D000293:Adolescent; D000328:Adult; D004247:DNA / Q000032:analysis; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D016898:Interferon-alpha / Q000097:blood / Q000235:genetics*; D007372:Interferons / Q000097:blood / Q000235:genetics; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; C469326:IFNA10 protein, human; C471357:IFNA17 protein, human; D016898:Interferon-alpha; D004247:DNA; D007372:Interferons