[Anticochlear antibodies titles measured by Western-blot and hearing recovery level after corticoid therapy in patients with sudden deafness].
OBJECTIVE
Detection of antichoclear antibodies in patients with sudden deafness (SD) ranges from five to forty one percent depending on authors. We tried to correlate the level of antibodies measured by Western-blot (WB) and hearing loss.


METHODS
Forty nine subjects bearing of SD and a positive WB for bovine cochlear antigen. Hearing loss average was measured at the onset and after treatment with deflazacort 1 mg/kg per day by means of audiometry, and antibody titles were quantified in the diluted sera.


RESULTS
Initial loss was 49.4+/-20.6%, and after corticotherapy it was 15.9+/-18.0%. There was no statistically significative correlation titles-hearing loss (y=0.1122x+30.613; R2=0.7552) nor titles-recovery (y=-0.0818x+8.,65; R2=0.3229).


CONCLUSIONS
Although predictive capability for treatment response is accepted for WB, quantifying of the antibody titles in patients with SD does not allow to make a prognosis about the average hearing recovery.
García Callejo
F J
FJ
Servicio de ORL. Hospital Clínico Universitario de Valencia. jgarciacall@hotmail.com
Velert Vila
M M
MM
Laporta
P
P
Orts Alborch
M H
MH
de Paula Vernetta
C
C
Marco Algarra
J
J
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015153:Blotting, Western; D003051:Cochlea / Q000276:immunology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D003639:Hearing Loss, Sudden / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D012074:Remission Induction
D001323:Autoantibodies; D005938:Glucocorticoids; D008775:Methylprednisolone