title: Occlusion of internal mammary grafts: a review of the potential causative factors.
abstract: The outcome of patient undergoing CABG is largely dependant on the long-term patency of the conduit used. Internal mammary artery (IMA) is considered whenever possible due to its improved long-term functionality over saphenous vein graft. However, a 10% rate of late arterial closure is described without well-known predictors. Chronic competition induced by a moderate coronary lesion on the bypassed native vessel is thought to be a major factor of arterial graft shrinkage even if conflicting data are reported in the available literature. Therefore, the decision to use an IMA to bypass a moderate native coronary lesion should be carefully weighted. When angiography is doubtful, more accurate functional investigations should be considered. Among them, pressure-derived fractional flow reserve could give an immediate answer of whether an intermediate lesion should be bypassed.
authors.affiliation: Service of Cardiology, University Center, Lausanne, Switzerland. alexandre.berger@hospvd.ch
authors.forename: A
authors.initials: A
authors.lastname: Berger
authors.forename: P A
authors.initials: PA
authors.lastname: MacCarthy
authors.forename: H
authors.initials: H
authors.lastname: Vanermen
authors.forename: B
authors.initials: B
authors.lastname: De Bruyne
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000502:physiology; D006083:Graft Occlusion, Vascular / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007387:Internal Mammary-Coronary Artery Anastomosis / Q000009:adverse effects*; D008323:Mammary Arteries; D012501:Saphenous Vein; D014654:Vascular Patency / Q000502:physiology