Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis.
We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The DeltalysA DeltapanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.
Sambandamurthy
Vasan K
VK
Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Derrick
Steven C
SC
Jalapathy
Kripa V
KV
Chen
Bing
B
Russell
Robert G
RG
Morris
Sheldon L
SL
Jacobs
William R
WR
D000818:Animals; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008239:Lysine / Q000378:metabolism; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000378:metabolism; D010205:Pantothenic Acid / Q000378:metabolism; D013997:Time Factors; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*; D032581:Tuberculosis Vaccines; D014613:Vaccines, Attenuated
D032581:Tuberculosis Vaccines; D014613:Vaccines, Attenuated; D010205:Pantothenic Acid; D008239:Lysine