Two new chymotrypsin inhibitors isolated from the Cyanobacterium Microcystis aeruginosa NIES-88.
Micropeptins 88-N (1) and 88-Y (2), new 3-amino-6-hydroxy-2-piperidone (Ahp)-containing cyclic depsipeptides, were isolated from Microcystis aeruginosa NIES-88. The structures were elucidated by analyses of HRFABMS, 1D and 2D NMR spectra, and chemical degradation. Micropeptins 88-N and 88-Y inhibited chymotrypsin. The inhibitory activities were closely related to the amino acid residue that was attached to the amino group of Ahp.
Yamaki
Hiroshi
H
Graduate School of Environmental Studies, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8579, Japan.
Sitachitta
Namthip
N
Sano
Tomoharu
T
Kaya
Kunimitsu
K
D000596:Amino Acids / Q000737:chemistry*; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D046931:Microcystis / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000596:Amino Acids; D047630:Depsipeptides; D011480:Protease Inhibitors; C497406:micropeptin 88-N; C497407:micropeptin 88-Y; D002918:Chymotrypsin