[Treatment of ejaculation disorders by midodrine (Gutron) per os. Retrospective study of about 16 subjects].
OBJECTIVE
We evaluate the efficiency and side effects of midodrine in the treatment of sperm transport disturbances.


METHODS
This retrospective study concerned patients addressed in Andrologia Department between 1995 and 2002 for treatment of sperm transport disturbances by administration of Midodrine per os (from 2.5 to 20 mg). Anterograde and retrogrades ejaculates (in urine sample) were examined.


RESULTS
Sixteen patients (middle age of 36 years) were included: 12 neurologic lesions (central or peripheral, with 3 diabetes), four post-surgical (urologic and digestive) ejaculatory incompetence. One patient obtained anterior and retrograde ejaculation, two patients obtained anterior ejaculation and six retrograde ejaculations by midodrine per os. This treatment was inefficient in eight subjects. Side effects were exceptional.


CONCLUSIONS
We obtained anterior or retrograde ejaculation in half of our population. The success was more important in patients with central neurologic injuries, diabetes or post-surgical troubles. In peripheral neurologic injuries, midodrine per os (maximal dose of 20 mg) was ineffective.


CONCLUSIONS
Our study demonstrates the efficiency and good tolerance of midodrine per os for treatment of sperm transport disturbances.
Blanchard-Dauphin
A
A
Service de médecine physique et réadaptation, hôpital Swynghedauw, CHRU, 59037 Lille cedex, France. a-blanchard-dauplin@chru-lille.fr
Rigot
J M
JM
Thevenon
A
A
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D004542:Ejaculation / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008879:Midodrine / Q000627:therapeutic use*; D012189:Retrospective Studies; D013083:Sperm Transport / Q000187:drug effects
D000316:Adrenergic alpha-Agonists; D008879:Midodrine