Four new prenylated isoflavonoids in Tadehagi triquetrum.
Investigation on the anthelminthic bioactive compounds of the ethanol extract of Tadehagi triquetrum resulted in the isolation of three new prenylated isoflavones, triquetrumones A (1), B (2), and C (3), and one new prenylated biisoflavanone, (R)-triquetrumone D (4), along with 16 known compounds, cyclokievitone (5), yukovanol (6), aromadendrin (7), kaempferol (8), astragalin (9), 2-O-methyl-l-chiro-inositol (10), galactitol (11), p-hydroxycinnamic acid (12), ursolic acid (13), betulinic acid (14), beta-sitosterol (15), daucosterol (16), stigmasterol (17), stigmasta-5,22-dien-3-O-beta-d-glucopyranoside (18), saccharose (19), and docosanoic acid (20). The structures of 1-4 were elucidated on the basis of spectroscopic and spectrometric methods. Compounds 1-3 displayed mild anthelminthic bioactivity, and compound 3 showed a significant binding ability to the estrogen receptor.
Xiang
Wei
W
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204 Yunnan, People's Republic of China. xiangwei@xtbg.ac.cn
Li
Rong-Tao
RT
Mao
Yun-Ling
YL
Zhang
Hong-Jie
HJ
Li
Sheng-Hong
SH
Song
Qi-Shi
QS
Sun
Han-Dong
HD
D000818:Animals; D000871:Anthelmintics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal; D004539:Eimeria / Q000187:drug effects; D000431:Ethanol; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D017368:Protein Prenylation
D000871:Anthelmintics; D004365:Drugs, Chinese Herbal; D007529:Isoflavones; D010936:Plant Extracts; C497610:triquetrumone A; C497614:triquetrumone B; C497613:triquetrumone C; C497611:triquetrumone D; D000431:Ethanol