Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT(7) receptor.
The synthesis of novel C6-aryl substituted derivatives of 3-(dimethylamino)chroman is described. The novel derivatives display 5-HT(7) receptor affinities that varies from nM to muM, indicating that this small set of derivatives constitute a novel and interesting starting point for further structure-serotonin 5-HT(7) activity relationship (SAR) studies.
Holmberg
Pär
P
Organic Pharmaceutical Chemistry, Uppsala University, PO Box 574, SE-751 23 Uppsala, Sweden.
Tedenborg
Lars
L
Rosqvist
Susanne
S
Johansson
Anette M
AM
D001665:Binding Sites; D002839:Chromans / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000737:chemistry* / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
D002839:Chromans; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C104425:serotonin 7 receptor