title: [Diffusion-weighted imaging in the diagnostic evaluation of the hydrocephalus in patients with acute or chronic increase in cerebral pressure].
abstract: OBJECTIVE
  To investigate whether diffusion-weighted imaging (DWI) in magnetic resonance imaging (MRI) provides additional information about the periventricular white matter for the assessment of hydrocephalus.
  
  
  METHODS
  Sixteen MRI examinations (11 with acutely increased cerebral pressure, 5 without symptoms) on 15 patients with hydrocephalus (4 patients with communicating hydrocephalus and 11 patients with obstructive hydrocephalus) were analyzed. One symptomatic patient subsequently became asymptomatic. We investigated the "apparent diffusion coefficient" (ADC) in the subcortical and periventricular white matter. The ADCs of the study patients were compared with those of a healthy control group.
  
  
  RESULTS
  Symptomatic patients with hydrocephalus, 6/11 showed periventricular edema and a significantly higher ADC values in the periventricular region than in the subcortical white matter. 5/11 symptomatic patients showed significantly higher ADC values even in the absence of periventricular interstitial edema (both groups contained patients with communicating and obstructive hydrocephalus). All 5 asymptomatic patients with hydrocephalus did not have a significantly higher ADC values in the periventricular region.
  
  
  CONCLUSIONS
  In patients with hydrocephalus and acutely increased cerebral pressure, DWI showed a significantly higher ADC values in the periventricular region even without visible interstitial edema on conventional MRI sequences.
authors.affiliation: Abteilung für Neuroradiologie, Universitätskliniken des Saarlandes, Homburg/Saar. ulrich.dorenbeck@uniklinik-saarland.de
authors.forename: U
authors.initials: U
authors.lastname: Dorenbeck
authors.forename: J
authors.initials: J
authors.lastname: Schlaier
authors.forename: S
authors.initials: S
authors.lastname: Feuerbach
authors.forename: J
authors.initials: J
authors.lastname: Seitz
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis* / Q000209:etiology; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged