title: Chronic myeloid leukemia following kidney transplantation.
abstract: Immunosuppressed renal recipients are at an increased risk of developing cancer. Leukemias are less frequent than other hematopoietic tumours and development of CML after immunosuppression is rare. We describe a 37-year-old male who presented with left-shifted leukocytosis, hypercellular bone marrow 32 months after the kidney transplant. G-banding karyotype revealed 46,XY,t(9;22)(q34;q11) and the diagnosis of chronic myeloid leukemia was made. This is the 13th case of CML after kidney transplant reported. Whether this CML appeared as a random phenomenon or chemically induced is a matter of debate. Some individuals might have an increased susceptibility to the effects of azathioprine.
authors.affiliation: Disciplina de Hematologia e Hemoterapia, UNIFESP-EPM, Rua Botucatu 740, 04023-900 São Paulo, SP Brazil.
authors.forename: Luís Arthur Flores
authors.initials: LA
authors.lastname: Pelloso
authors.forename: Mireille Guimarães Vaz de
authors.initials: MG
authors.lastname: Campos
authors.forename: Marília
authors.initials: M
authors.lastname: Nascimento
authors.forename: Maria Regina Régis
authors.initials: MR
authors.lastname: Silva
authors.forename: José Osmar Medina
authors.initials: JO
authors.lastname: Pestana
authors.forename: Maria de Lourdes L F
authors.initials: Mde L
authors.lastname: Chauffaille
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology* / Q000276:immunology*; D008297:Male
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine