title: Effectiveness of a divalent vaccine for sole, Solea senegalensis (Kaup), against Vibrio harveyi and Photobacterium damselae subsp. piscicida.
abstract: The protection of cultured sole, Solea senegalensis, against Vibrio harveyi and Photobacterium damselae subsp. piscicida was evaluated following the use of a divalent vaccine prepared with formalized whole cells and extracellular products of virulent strains of both pathogenic microorganisms and administered by the immersion route. Two prolonged immersions of 5-10 g fish in the divalent bacterin at a 1-month interval gave high levels of protection similar to those obtained when the respective monovalent vaccines were administered by the intraperitoneal route [relative percentage of survival (RPS) values >70%], which indicates that the former procedure can be a useful strategy with small fish. The high protection afforded by the divalent vaccine in sole lasted for 4 months after which the RPS values against both pathogens decreased significantly.
authors.affiliation: Department of Microbiology, Faculty of Sciences, University of Malaga, Malaga, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Arijo
authors.forename: R
authors.initials: R
authors.lastname: Rico
authors.forename: M
authors.initials: M
authors.lastname: Chabrillon
authors.forename: P
authors.initials: P
authors.lastname: Diaz-Rosales
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Manzanares
authors.forename: M C
authors.initials: MC
authors.lastname: Balebona
authors.forename: B
authors.initials: B
authors.lastname: Magariños
authors.forename: A E
authors.initials: AE
authors.lastname: Toranzo
authors.forename: M A
authors.initials: MA
authors.lastname: Moriñigo
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D005393:Fish Diseases / Q000382:microbiology / Q000517:prevention & control*; D005412:Flatfishes; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D007101:Immersion; D010776:Photobacterium / Q000276:immunology*; D016019:Survival Analysis; D014733:Vibrio / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines