title: NOTCH1 pathway: a molecular target in T-cell cancers?
authors.affiliation: Department of Haematology and BMT, Silesian Medical University, 40-023 Katowice, Poland. holow@slam.katowice.pl
authors.forename: Jerzy
authors.initials: J
authors.lastname: Holowiecki
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D053829:Amyloid Precursor Protein Secretases; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016282:Aspartic Acid Endopeptidases; D019281:Dimerization; D016503:Drug Delivery Systems; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy* / Q000378:metabolism; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000378:metabolism; D011480:Protease Inhibitors / Q000627:therapeutic use; D051881:Receptor, Notch1; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects; D014157:Transcription Factors / Q000187:drug effects / Q000235:genetics / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000970:Antineoplastic Agents; C497761:NOTCH1 protein, human; D009687:Nuclear Proteins; C465618:PCNP protein, human; D011480:Protease Inhibitors; D051881:Receptor, Notch1; D011956:Receptors, Cell Surface; D014157:Transcription Factors; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human