title: No epsilon4 gene dose effect on hippocampal atrophy in a large MRI database of healthy elderly subjects.
abstract: The effect of ApoE genotype on grey matter (GM) atrophy was studied on a cohort of 750 healthy elderly volunteers (age range 63-75 years). High-resolution T1-weighted MR images were processed using both voxel-based morphometry and region of interest analysis for hippocampal volume estimation. Significant decrease of grey matter in epsilon(4) homozygous subjects (n = 12), as compared both to epsilon(4) heterozygous subjects (n = 175) and to noncarrier (n = 563) subjects, was found bilaterally in the medial temporal lobe, including the hippocampus, and extending over the superior temporal gyrus. By contrast, no significant difference was observed between epsilon(4) heterozygous subjects and noncarriers at the level of the medial temporal lobe. Follow-up of the cohort cognitive performances over 4 years after their MRI exam revealed that, as compared to noncarrier subjects, the relative risk of cognitive impairment was 5.9 for epsilon(4) homozygous subjects (P = 0.03), while it was not different from 1 for epsilon(4) heterozygous subjects (P = 0.92). These findings indicate that, in the age range of this cohort, ApoE-4 effects on cortical atrophy and cognitive performances of healthy elderly are limited to epsilon(4) homozygous subjects.
authors.affiliation: Groupe d'Imagerie Neurofonctionnelle, UMR 6194, CNRS, CEA, Universités de Caen and Paris 5, GIP Cyceron, Boulevard Becquerel BP5229, F-14074 Caen, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Lemaître
authors.forename: Fabrice
authors.initials: F
authors.lastname: Crivello
authors.forename: Carole
authors.initials: C
authors.lastname: Dufouil
authors.forename: Blandine
authors.initials: B
authors.lastname: Grassiot
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
authors.forename: Annick
authors.initials: A
authors.lastname: Alpérovitch
authors.forename: Bernard
authors.initials: B
authors.lastname: Mazoyer
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D001284:Atrophy; D002421:Caudate Nucleus / Q000473:pathology; D003071:Cognition / Q000502:physiology; D016208:Databases, Factual; D007839:Functional Laterality / Q000502:physiology; D018628:Gene Dosage; D005838:Genotype; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests
chemical_list: D001057:Apolipoproteins E