title: Effect of peracetic acid reprocessing on the transport characteristics of polysulfone hemodialyzers.
abstract: Peracetic acid is used extensively for reprocessing hemodialyzers, despite several indications that reprocessing alters the dialyzer transport characteristics. The objective of this study was to obtain quantitative data for the effects of peracetic acid reprocessing on the clearance and sieving coefficients of urea, vitamin B12, and polydisperse dextrans using Fresenius F80A polysulfone dialyzers. Reprocessing restored the urea and vitamin B12 clearance to close to their original values. However, the reprocessed dialyzers had substantially lower clearance of the larger molecular weight dextrans, which was attributed to reductions in the effective pore size caused by residual plasma proteins within the membrane. Storage in peracetic acid provided some additional removal of residual proteins, although the clearance and sieving coefficients of the larger dextrans remained well below their original values. Peracetic acid caused no degradation of the membrane polymer, in sharp contrast to results obtained with bleach reprocessing.
authors.affiliation: Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Susanne H
authors.initials: SH
authors.lastname: Wolff
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Zydney
mesh_terms: D001672:Biocompatible Materials; D004202:Disinfectants / Q000494:pharmacology*; D004203:Disinfection / Q000379:methods; D006801:Humans; D008567:Membranes, Artificial; D010463:Peracetic Acid / Q000494:pharmacology*; D011108:Polymers; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones
chemical_list: D001672:Biocompatible Materials; D004202:Disinfectants; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D010463:Peracetic Acid