A modular, one-pot, four-component synthesis of polysubstituted 1,3-oxazolidines.
A modular, one-pot, two-step, four-component synthesis of polysubstituted 1,3-oxzolidines is described. The method comprises two linked domino processes: an organocatalyzed domino reaction of alkyl propiolate and an aliphatic aldehydes and a microwave-assisted amine addition cyclization domino process. An alternative modular, one-pot, three-step, four-component synthesis has also been developed by linking the organocatalyzed domino process to a sequential amine addition/Yb(OTf)(3)-catalyzed enamine cyclization reaction.
Tejedor
David
D
Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Islas Canarias, Spain.
Santos-Expósito
Alicia
A
González-Cruz
David
D
Marrero-Tellado
José Juan
JJ
García-Tellado
Fernando
F
D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry
D010080:Oxazoles; D011355:Prodrugs; C064210:oxazolidine