title: Nanostructured systems for biological materials.
abstract: The sol-gel process is a chemical technique for immobilizing biomolecules in an inorganic, transparent matrix. The dopant biomolecules reside in an interconnected mesoporous network and become part of the nanostructured architecture of the entire material. In this chapter, we review the sol-gel immobilization approach and discuss how it leads to the stabilization of a number of proteins against aggressive chemical and thermal environments. We also review the sensor applications of this material that result from having analyte molecules diffuse through the matrix and reach the immobilized biomolecule.
authors.affiliation: Department of Materials Science and Engineering, University of California at Los Angeles, Los Angeles, CA, USA.
authors.forename: Esther H
authors.initials: EH
authors.lastname: Lan
authors.forename: Bruce
authors.initials: B
authors.lastname: Dunn
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Zink
mesh_terms: D015374:Biosensing Techniques; D002942:Circular Dichroism; D003402:Creatine Kinase / Q000737:chemistry; D004795:Enzyme Stability / Q000502:physiology; D005898:Glass / Q000737:chemistry; D006358:Hot Temperature; D007118:Immunoassay; D036103:Nanotechnology; D013997:Time Factors
chemical_list: D003402:Creatine Kinase