title: Two cases of orbital adenocarcinoma treated with heavy charged carbon particle irradiation.
abstract: BACKGROUND
  Orbital adenocarcinoma is a relatively rare, primary orbital malignant epithelial tumor, and shares the poor prognosis of orbital adenoid cystic carcinoma. We report the cases of two patients with orbital adenocarcinoma who were treated with heavy charged carbon particle irradiation and followed up for more 6 years.
  
  
  METHODS
  Two patients with orbital adenocarcinoma, 62 and 74 years old, received 57.6 GyE of heavy charged particle irradiation therapy.
  
  
  RESULTS
  In both cases, the size of the tumor gradually decreased after carbon ion irradiation therapy. No recurrences or metastasis of the tumor were found for more than 6 years.
  
  
  CONCLUSIONS
  Orbital adenocarcinoma has a poor prognosis in general. Two patients with orbital adenocarcinoma were treated with heavy charged carbon particle irradiation therapy and had a relatively good outcome and good prognosis. We believe that heavy charged carbon particle irradiation therapy is a promising therapy for orbital adenoid cystic carcinoma and adenocarcinoma.
authors.affiliation: Department of Ophthalmology and Visual Science, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. aki-uiui@tc5.so-net.ne.jp
authors.forename: Aki
authors.initials: A
authors.lastname: Hirai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizota
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Mine
authors.forename: Jun-etsu
authors.initials: JE
authors.lastname: Mizoe
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000532:radiotherapy*; D000368:Aged; D002247:Carbon Isotopes / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D002247:Carbon Isotopes