title: Evaluation of new Japanese diagnostic criteria for disseminated intravascular coagulation in critically ill patients.
abstract: New Japanese diagnostic criteria were prepared for disseminated intravascular coagulation (DIC) in critically ill patients and their usefulness was compared with the criteria of the International Society of Thrombosis and Haemostasis (ISTH) and those of the Japan Ministry of Health and Welfare (JMHW). In a retrospective study of patients with platelet counts of less than 150 x10(3)/mL, 52 cases (33.3%), 66 cases (42.3%), and 101 cases (64.7%) were diagnosed as DIC by the ISTH, JMHW, and new Japanese DIC criteria, respectively. The DIC state as diagnosed by the new Japanese DIC criteria included both DIC states as diagnosed by ISTH or JMHW criteria. Some DIC states diagnosed by the JMHW criteria included those diagnosed by ISHT criteria but this was not universal. The mortality of DIC as diagnosed by the ISTH or JMHW criteria was markedly high, compared to that for DIC diagnosed by the new Japanese criteria. The mortality of patients without DIC by ISTH was also high when they were diagnosed as DIC by the new Japanese criteria. The frequency of DIC by each set of diagnostic criteria was significantly higher in patients with infection than in those without infection. The mortality of DIC by each set of diagnostic criteria was significantly higher in patients with infection than in those without infection, and the mortality of overt-DIC by ISTH diagnostic criteria was also high in patients without infection.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Hokkaido University, Graduate School of Medicine, Sapporo-city, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Gando
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.forename: Hidesaku
authors.initials: H
authors.lastname: Asakura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Iba
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Eguchi
authors.forename: Kohji
authors.initials: K
authors.lastname: Okamoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ohtomo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kawasugi
authors.forename: Shin
authors.initials: S
authors.lastname: Koga
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Koseki
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsuji
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Mayumi
authors.forename: Atsuo
authors.initials: A
authors.lastname: Murata
authors.forename: Masao
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Shigeatu
authors.initials: S
authors.lastname: Endo
mesh_terms: D016638:Critical Illness; D004211:Disseminated Intravascular Coagulation / Q000145:classification* / Q000175:diagnosis* / Q000453:epidemiology / Q000401:mortality; D005260:Female; D006801:Humans; D007239:Infections / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies