Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior.
Previous studies have reported hyperactivation of catecholaminergic systems and elevated concentrations of corticotropin-releasing-hormone (CRH) in the cerebrospinal fluid (CSF) of child maltreatment victims or combat veterans with post-traumatic stress disorder (PTSD). This study investigated the CSF concentrations of CRH and monoamine metabolites in rhesus macaque mothers that physically abused their infants and had themselves been abused as infants. Ten abusive mothers and 10 controls served as study subjects. All animals were sampled for CSF during pregnancy and the postpartum period. Focal observations of social and maternal behavior were also made. Abusive mothers had significantly higher CSF concentrations of CRH and 5-HIAA than controls. Across both subjects and controls, higher CRH, 5-HIAA and MHPG concentrations were associated with anti-social behavior patterns including a high frequency of maternal aggression, infant rejection, and a low frequency of contacts received from other individuals. These findings are consistent with those of previous primate and human studies and suggest that the neurobiological alterations associated with infant abuse may play an important role in the occurrence of maladaptive behavior in adulthood, including the perpetuation of infant abuse across generations.
Maestripieri
Dario
D
Institute for Mind and Biology, University of Chicago, 5730 S. Woodlawn Avenue, Chicago, IL 60637, USA. dario@uchicago.edu
Lindell
Stephen G
SG
Ayala
Alejandro
A
Gold
Philip W
PW
Higley
J Dee
JD
D000374:Aggression / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008253:Macaca mulatta; D008425:Maternal Behavior / Q000502:physiology*; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D009035:Mothers / Q000523:psychology*; D009446:Neurobiology; D011247:Pregnancy; D011863:Radioimmunoassay / Q000379:methods; D012044:Regression Analysis; D012919:Social Behavior
D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D003346:Corticotropin-Releasing Hormone; D006719:Homovanillic Acid