title: Familial neurocardiogenic (vasovagal) syncope.
abstract: Vasovagal syncope (VSS) is an exaggerated tendency towards the common faint caused by a sudden and profound hypotension with or without bradycardia. The etiology of VVS is unknown though several lines of evidence indicate central and peripheral abnormalities of sympathetic function. Studies however indicate a strong heritable component to the etiology of VVS in over 20% of cases. Here, we report the findings from a family that shows apparently autosomal dominant VVS in at least three generations. Clinical findings included an absence of any discernible cardiac or autonomic abnormalities and reproducible hypotension on tilt table testing in affected family members.
authors.affiliation: Cardiovascular Investigation Unit (Institute for Ageing and Health), School of Clinical Medical Sciences, Newcastle, United Kingdom. julianewton@blueyonder.co.uk
authors.forename: Julia L
authors.initials: JL
authors.lastname: Newton
authors.forename: Simon
authors.initials: S
authors.lastname: Kerr
authors.forename: Jessie
authors.initials: J
authors.lastname: Pairman
authors.forename: Andrew
authors.initials: A
authors.lastname: McLaren
authors.forename: Michael
authors.initials: M
authors.lastname: Norton
authors.forename: Rose Anne
authors.initials: RA
authors.lastname: Kenny
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Morris
mesh_terms: D001794:Blood Pressure; D005192:Family Health; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D010375:Pedigree; D012964:Sodium / Q000652:urine; D019462:Syncope, Vasovagal / Q000235:genetics / Q000503:physiopathology* / Q000652:urine; D018667:Tilt-Table Test
chemical_list: D012964:Sodium