Effect of topical nasal steroid sprays on nasal mucosa and ciliary function.
OBJECTIVE
This review was conducted to examine current evidence focusing on the effect of nasal steroid sprays on nasal ciliary function.


RESULTS
Review of current literature suggests that long term effects of topical corticosteroid nasal sprays are safe and fail to cause damage to local nasal structure and function.


CONCLUSIONS
The use of corticosteroid nasal sprays for the treatment of allergic rhinitis is widely accepted. Popularity of this class of medications is based on a well-established combination of efficacy, tolerability, and safety. Although current literature suggests that the use of intranasal steroids is indeed safe, increasing indications for prolonged administration continue to fuel debate regarding the long-term effect on local nasal structure and function. The purpose of this article is to review current literature addressing the effects of the components of local intranasal steroid sprays on the structure and function of the nasal mucosa.
Verret
D J
DJ
Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9035, USA.
Marple
Bradley F
BF
D000281:Administration, Intranasal; D001548:Benzalkonium Compounds / Q000008:administration & dosage / Q000494:pharmacology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D009079:Mucociliary Clearance / Q000187:drug effects*; D009297:Nasal Mucosa / Q000187:drug effects*; D011310:Preservatives, Pharmaceutical / Q000008:administration & dosage / Q000494:pharmacology; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*
D001548:Benzalkonium Compounds; D005938:Glucocorticoids; D011310:Preservatives, Pharmaceutical