Novel avian influenza H7N3 strain outbreak, British Columbia.
Genome sequences of chicken (low pathogenic avian influenza [LPAI] and highly pathogenic avian influenza [HPAI]) and human isolates from a 2004 outbreak of H7N3 avian influenza in Canada showed a novel insertion in the HA0 cleavage site of the human and HPAI isolate. This insertion likely occurred by recombination between the hemagglutination and matrix genes in the LPAI virus.
Hirst
Martin
M
British Columbia Cancer Agency (BCCA) Genome Sciences Centre, Vancouver, British Columbia, Canada.
Astell
Caroline R
CR
Griffith
Malachi
M
Coughlin
Shaun M
SM
Moksa
Michelle
M
Zeng
Thomas
T
Smailus
Duane E
DE
Holt
Robert A
RA
Jones
Steven
S
Marra
Marco A
MA
Petric
Martin
M
Krajden
Mel
M
Lawrence
David
D
Mak
Annie
A
Chow
Ron
R
Skowronski
Danuta M
DM
Tweed
S Aleina
SA
Goh
SweeHan
S
Brunham
Robert C
RC
Robinson
John
J
Bowes
Victoria
V
Sojonky
Ken
K
Byrne
Sean K
SK
Li
Yan
Y
Kobasa
Darwyn
D
Booth
Tim
T
Paetzel
Mark
M
D000595:Amino Acid Sequence; D000818:Animals; D001955:British Columbia / Q000453:epidemiology; D002645:Chickens; D004196:Disease Outbreaks / Q000662:veterinary*; D006801:Humans; D009980:Influenza A virus / Q000235:genetics* / Q000472:pathogenicity; D005585:Influenza in Birds / Q000453:epidemiology* / Q000821:virology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D011487:Protein Conformation; D016415:Sequence Alignment; D014764:Viral Proteins / Q000737:chemistry
D014764:Viral Proteins