title: Orally fast disintegrating tablets: developments, technologies, taste-masking and clinical studies.
abstract: Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail FDT technologies based on lyophilization, molding, sublimation, and compaction, as well as approaches to enhancing the FDT properties, such as spray-drying, moisture treatment, sintering, and use of sugar-based disintegrants. In addition, taste-masking technologies, experimental measurements of disintegration times, and clinical studies are also discussed.
authors.affiliation: Purdue University, Departments of Pharmaceutics and Biomedical Engineering, West Lafayette, Indiana 47907-2091, USA.
authors.forename: Yourong
authors.initials: Y
authors.lastname: Fu
authors.forename: Shicheng
authors.initials: S
authors.lastname: Yang
authors.forename: Seong Hoon
authors.initials: SH
authors.lastname: Jeong
authors.forename: Susumu
authors.initials: S
authors.lastname: Kimura
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006801:Humans; D012995:Solubility; D013607:Tablets; D013649:Taste; D013678:Technology, Pharmaceutical
chemical_list: D013607:Tablets