Suaveolindole, a new mass-limited antibacterial indolosesquiterpene from Greenwayodendron suaveolens obtained via high-throughput natural products chemistry methods.
Utilizing high-throughput isolation, purification, and analysis methods applied to a natural products library, a new mass-limited antibacterial indolosesquiterpene, suaveolindole (1), was obtained from Greenwayodendron suaveolens. The miniaturization of the structure elucidation of 1 was performed primarily using the CapNMR probe. Compound 1 was found to possess significant in vitro antibacterial activity against the Gram-positive bacteria Bacillus subtilis (ATCC 43223), Staphylococcus aureus (ATTC 6538P), and methicillin-resistant Staphylococcus aureus (ATTC 33591), with MIC values of 4, 8, and 8 microg/mL, respectively.
Yoo
Hye-Dong
HD
Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., San Diego, California 92121, USA.
Cremin
Peadar A
PA
Zeng
Lu
L
Garo
Eliane
E
Williams
Caroline T
CT
Lee
Chris M
CM
Goering
Matt G
MG
O'Neil-Johnson
Mark
M
Eldridge
Gary R
GR
Hu
Jin-Feng
JF
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D005638:Fruit / Q000737:chemistry; D005681:Gabon; D007711:Klebsiella pneumoniae / Q000187:drug effects; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes; C498139:suaveolindole