Pharmacomodulation of a sulfamide 5-HT6 receptor ligand.
A series of N-omega-aminoalkyl- or N-omega-amidinoalkyl-2,4,6-triisopropyl benzenesulfonamides has been synthesized and their respective affinity indices on 5-HT6 receptor determined. This evaluation clearly showed that the compounds possessing an arylpiperazine moiety or an amidine function exhibited good affinity for the model.
Renault
Jacques
J
UPRES EA 2234- Institut de Chimie de Rennes, Faculté des Sciences Biologiques et Médicales, Université de Rennes 1, 35043 Rennes, France. jacques.renault@univ-rennes1.fr
Bernard
Aurelie
A
Brajeul
Solenn
S
Verhaeghe
Pierre
P
Butt
Sabrina
S
Fabis
Frederic
F
Dauphin
François
F
Uriac
Philippe
P
Rault
Sylvain
S
D015195:Drug Design; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D011985:Receptors, Serotonin / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000096926:Benzenesulfonamides
D008024:Ligands; D011985:Receptors, Serotonin; D013449:Sulfonamides; D000096926:Benzenesulfonamides; C097216:serotonin 6 receptor