Mechanisms of translational control by the 3' UTR in development and differentiation.
Translational control plays a major role in early development, differentiation and the cell cycle. In this review, we focus on the four main mechanisms of translational control by 3' untranslated regions: 1. Cytoplasmic polyadenylation and deadenylation; 2. Recruitment of 4E binding proteins; 3. Regulation of ribosomal subunit binding; 4. Post-initiation repression by microRNAs. Proteins with conserved functions in translational control during development include cytoplasmic polyadenylation element binding proteins (CPEB/Orb), Pumilio, Bruno, Fragile X mental retardation protein and RNA helicases. The translational regulation of the mRNAs encoding cyclin B1, Oskar, Nanos, Male specific lethal 2 (Msl-2), lipoxygenase and Lin-14 is discussed.
de Moor
Cornelia H
CH
Centre for Biochemistry and Cell Biology, School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH, UK. cornelia.demoor@nottingham.ac.uk
Meijer
Hedda
H
Lissenden
Sarah
S
D020413:3' Untranslated Regions / Q000502:physiology*; D000241:Adenosine / Q000737:chemistry; D002453:Cell Cycle; D002454:Cell Differentiation; D039561:Eukaryotic Initiation Factor-4E / Q000378:metabolism; D005718:Gametogenesis; D018507:Gene Expression Regulation, Developmental; D035683:MicroRNAs / Q000502:physiology; D011108:Polymers / Q000737:chemistry; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000378:metabolism
D020413:3' Untranslated Regions; D039561:Eukaryotic Initiation Factor-4E; D035683:MicroRNAs; D011108:Polymers; C069424:polyadenosine; D000241:Adenosine