Heart resistance to oxidative stress in rats of different genetic strains.
In August rats reperfusion after regional myocardial ischemia in situ or intracoronary administration of hydrogen peroxide less significantly suppressed contractile activity of the heart compared to Wistar rats. Activities of catalase and superoxide dismutase in the myocardium during reperfusion remained unchanged in August rats. In Wistar rats a profound inhibition of cardiac function was accompanied by a decrease in enzyme activity.
Belkina
L M
LM
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences; Russian Cardiology Research-and-Production Center, Russian Ministry of Health, Moscow, Russia. lmgb@yandex.ru
Lakomkin
V L
VL
Zhukova
A G
AG
Kirillina
T N
TN
Saltykova
V A
VA
Sazontova
T G
TG
Kapel'ko
V I
VI
D000818:Animals; D002374:Catalase / Q000378:metabolism; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000201:enzymology* / Q000503:physiopathology; D009206:Myocardium / Q000201:enzymology*; D018384:Oxidative Stress / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism*
D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase