Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates.
Enhancement of the relaxivities of Gd-based MRI contrast agents is achieved by placing the metal ion at the barycentre of the molecular complex in order to improve motional coupling.
Fulton
David A
DA
Department of Chemistry, University of Durham, South Road, Durham, UK DH1 3LE.
O'Halloran
Mark
M
Parker
David
D
Senanayake
Kanthi
K
Botta
Mauro
M
Aime
Silvio
S
D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D015394:Molecular Structure; D008970:Molecular Weight; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D003287:Contrast Media; D050091:Dendrimers; D009942:Organometallic Compounds; D005682:Gadolinium