title: Calmodulin methionine residues are targets for one-electron oxidation by hydroxyl radicals: formation of S[therefore]N three-electron bonded radical complexes.
abstract: The one-electron oxidation of calmodulin, studied on the microsecond timescale by pulse radiolysis, leads to methionine sulfide radical cations, which complex to adjacent amide groups to form three-electron bonded intermediates.
authors.affiliation: Laboratory of Inorganic Chemistry, ETH Zürich, CH-8093 Zürich, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Nauser
authors.forename: Michael
authors.initials: M
authors.lastname: Jacoby
authors.forename: Willem H
authors.initials: WH
authors.lastname: Koppenol
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Squier
authors.forename: Christian
authors.initials: C
authors.lastname: Schöneich
mesh_terms: D002147:Calmodulin / Q000737:chemistry*; D004583:Electrons; D017665:Hydroxyl Radical / Q000737:chemistry*; D008715:Methionine / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D017434:Protein Structure, Tertiary
chemical_list: D002147:Calmodulin; D017665:Hydroxyl Radical; D008715:Methionine