Acyl sulfonamide anti-proliferatives. Part 2: activity of heterocyclic sulfonamide derivatives.
The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay.
Mader
Mary M
MM
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. mader_mary@lilly.com
Shih
Chuan
C
Considine
Eileen
E
Dios
Alfonso De
AD
Grossman
Cora Sue
CS
Hipskind
Philip A
PA
Lin
Ho-Shen
HS
Lobb
Karen L
KL
Lopez
Beatriz
B
Lopez
José E
JE
Cabrejas
Luisa M Martin
LM
Richett
Michael E
ME
White
Wesley T
WT
Cheung
Yiu-Yin
YY
Huang
Zhongping
Z
Reilly
John E
JE
Dinn
Sean R
SR
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014471:Umbilical Veins / Q000166:cytology; D042461:Vascular Endothelial Growth Factor A
D006574:Heterocyclic Compounds, 2-Ring; D013449:Sulfonamides; D042461:Vascular Endothelial Growth Factor A