[Study on quality evaluation methods of pretreatment for polystyrene-type macroporous absorbing resins].
OBJECTIVE
To establish a GC method using wide bore open tubular columns f or controlling pretreatment for polystyrene-type macroporous absorbing resins and its eligible standard.


METHODS
A model macroporous absorbing resins made in our lab was eluted by anhydrous alcohol. The residual solvents in elution (xylene, styrene, diethylbenzene, divinybenzene, decane) were assayed by GC. When the residual solvents can not be detected, the pretreatment is eligible. Compare this method with the methods referring in the literatures.


RESULTS
When using this method to control the pretreatment, the resins need to be elute 11 times with anhydrous alcocol. When using "adding several times water in the alcohol elution will not be turbid" to control the pretreatment, the resins need to be elute 3 times with anhydrous alcocol. When using "the elution have no UV absorption between the wavelength 200-400 nm" to control the pretreatment, the resins need to be elute over 20 times with anhydrous alcocol.


CONCLUSIONS
The method is simple and feasible.
Deng
Liang
L
West China Faculty of Pharmacy, Sichuan University, Chengdu 610041, China.
Ye
Li-ming
LM
Hou
Shi-xiang
SX
Chen
Gang
G
Chen
Cong
C
D002849:Chromatography, Gas / Q000295:instrumentation / Q000379:methods*; D004340:Drug Contamination; D004364:Pharmaceutical Preparations / Q000032:analysis; D011786:Quality Control; D012117:Resins, Synthetic; D020058:Styrene / Q000032:analysis*
D004364:Pharmaceutical Preparations; D012117:Resins, Synthetic; D020058:Styrene