title: Oxytocin during myomectomy: a randomized study.
abstract: OBJECTIVE
  To evaluate the influence of oxytocin on peroperative blood loss during myomectomy.
  
  
  METHODS
  From October 1998 to May 2002, 94 patients requiring surgical myomectomy by laparotomy or by the vaginal approach were enrolled in a randomized double blind study. Patients were randomized to two groups. In the first group (47 patients) oxytocin was administered during myomectomy and in the second group (47 patients) a placebo was used. The main outcome measures were peroperative blood loss and rates of blood transfusion and autotransfusion.
  
  
  RESULTS
  Peroperative blood loss was no different between the oxytocin group and the placebo group (508 +/- 558 ml versus 451 +/- 336 ml; P=0.55). Rates of autotransfusion and blood transfusion were also similar in both groups.
  
  
  CONCLUSIONS
  Administration of oxytocin during myomectomy did not reduce peroperative blood loss in our study. The benefits of using oxytocin to prevent hemorrhage during myomectomy seem to be limited.
authors.affiliation: Service de Gynécologie, Hôpital La Conception, 147 Boulevard Baille, 13385 Marseille, France. aagostini@mail.ap-hm.fr
authors.forename: Aubert
authors.initials: A
authors.lastname: Agostini
authors.forename: Isabelle
authors.initials: I
authors.lastname: Ronda
authors.forename: Fabrice
authors.initials: F
authors.lastname: Franchi
authors.forename: Florence
authors.initials: F
authors.lastname: Bretelle
authors.forename: Valérie
authors.initials: V
authors.lastname: Roger
authors.forename: Ludovic
authors.initials: L
authors.lastname: Cravello
authors.forename: Bernard
authors.initials: B
authors.lastname: Blanc
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion; D004311:Double-Blind Method; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007889:Leiomyoma / Q000601:surgery*; D008875:Middle Aged; D010121:Oxytocin / Q000008:administration & dosage*; D010919:Placebos; D014594:Uterine Neoplasms / Q000601:surgery*
chemical_list: D006454:Hemoglobins; D010919:Placebos; D010121:Oxytocin