Effector CD8+T cells are suppressed by measles virus infection during delayed type hypersensitivity reaction.
Measles virus infection reduces or abolishes delayed type hypersensitivity reactions (DTH) in humans. We have previously shown that the primary 2,4-dinitrofluorobenzene (DNFB) response is temporarily suppressed by measles virus in cotton rats. Here, we demonstrate that also the secondary DNFB response (cutaneous hypersensitivity [CHS]) is suppressed in cotton rats by measles virus infection. As in mice, DNFB specific CD8 T cells are the predominant T cell response in cotton rats. After MV infection, CD8 T cells are reduced in their proliferative capacity whereas the CD4/CD8 ratio, the number and activation status of CD8 T cells is not affected. As a result of impaired proliferation of DNFB specific T cells the DTH response (measured as ear swelling) is reduced in measles virus infected cotton rats. At the same time as DNFB specific T cell responses are suppressed, spontaneous proliferation of lymphocytes as evidence for immune activation is found.
Streif
Sabine
S
Institut fuer Virologie und Immunbiologie, Wuerzburg, Germany.
Pueschel
Karin
K
Tietz
Annette
A
Blanco
Jorge
J
Meulen
Volker Ter
VT
Niewiesk
Stefan
S
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004139:Dinitrofluorobenzene / Q000008:administration & dosage / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology*; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008297:Male; D008457:Measles / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D016205:Sigmodontinae
D004139:Dinitrofluorobenzene