Live birth of a normal healthy baby after a frozen embryo transfer with blastocysts that were frozen and thawed twice.
OBJECTIVE
To report the birth of a normal healthy baby after a frozen ET (FET) with blastocysts that were frozen and thawed twice.


METHODS
Case report.


METHODS
Private infertility practice.


METHODS
A 26-year-old female who presented with male factor infertility and polycystic ovarian disease.


METHODS
One cycle of IVF-ET and FET no. 1 followed by the refreezing of blastocysts and FET no. 2.


METHODS
Clinical pregnancy and live birth.


RESULTS
Thirty-six months after a successful IVF-ET cycle, FET no. 1 was performed with eight frozen blastocysts that were thawed. One blastocyst was transferred to the uterus and four were refrozen. The first FET resulted in a singleton pregnancy that ended in a spontaneous abortion after 7 weeks' gestation. Six months later, FET no. 2 was performed. All four refrozen blastocysts were thawed and transferred to the uterus. The second FET resulted in a singleton pregnancy and the birth of a normal healthy baby (male) weighing 3,005 g after 38 weeks' gestation.


CONCLUSIONS
Human blastocysts can be refrozen/thawed and produce a normal healthy baby after an FET. Further studies will be required to determine survival, implantation, and live birth rates with refrozen/thawed human blastocysts.
Smith
L Keith
LK
The Center for Reproductive Medicine, Lubbock, Texas 79410, USA. crmivflab@yahoo.com
Roots
Ellen H
EH
Dorsett
M Janelle Odom
MJ
D000328:Adult; D001755:Blastocyst / Q000502:physiology*; D015925:Cryopreservation; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy