Olfactory epithelium destruction by ZnSO4 modified sulfhydryl oxidase expression in mice.
Experimental destruction of olfactory neurons stimulates proliferation and differentiation of local neural precursors and is used as a model to study in vivo mechanisms for degeneration and regeneration of the nervous system. Quiescin-sulfhydryl oxidases (QSOX) have a potential role in the control of the cell cycle or growth regulation and have recently been described in the central nervous system. In mice, we show an expression of QSOX in olfactory mucosa. Northern- and western-blot analysis show that the destruction of olfactory epithelium is associated with a reversible reduction in QSOX expression. Interestingly, QSOX is not localized in olfactory neurons (ON) but in cells of the lamina propria, suggesting that olfactory epithelium destruction may act as a signal of down-regulation of QSOX expression.
Bon
Karine
K
Laboratoire de Neurosciences, EA 481, IFR133, Université de Franche-Comté, UFR Sciences et Techniques, 1 Place Maréchal Leclerc, 25030 Besançon cedex, France.
Adami
Pascale
P
Esnard
Frédéric
F
Jouvenot
Michèle
M
Versaux-Bottéri
Claudine
C
D000818:Animals; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D009831:Olfactory Mucosa / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology*; D010088:Oxidoreductases / Q000096:biosynthesis* / Q000235:genetics; D019287:Zinc Sulfate / Q000737:chemistry / Q000494:pharmacology*; D050862:Oxidoreductases Acting on Sulfur Group Donors
D010088:Oxidoreductases; D019287:Zinc Sulfate; D050862:Oxidoreductases Acting on Sulfur Group Donors