title: Novel ceramides and a new glucoceramide from the roots of Incarvillea arguta.
abstract: Novel ceramides, rel-(3S,4S,5S)-3-[(2R)-2-hydroxycosanoyl-hexacosanoylamino]-4-hydroxy-5-[(4Z)-tetradecane-4-ene]-2,3,4,5-tetrahydrofuran (1a-g), and a new glucoceramide, 1-O-beta-D-glucopyranosyl-(2S,3S,4R,8E)-2-[(2R)-2-hydroxytetracosanoylamino]-1,3,4-octodecanetriol-8-ene (2) were isolated from the aqueous ethanolic extract of the roots of Incarvillea arguta, together with eight known compounds: beta-sitosterol (3), oleanolic acid (4), ursolic acid (5), piperin (6), maslinic acid (7), beta-sitosterol 6'-O-acyl-beta-D-glucopyranoside (8), 8-epideoxyloganic acid (9), and plantarenaloside (10). Their structures were elucidated on the basis of spectral data including IR, MS, NMR [1H NMR, 13C NMR (distortionless enhancement by polarization transfer), 1H-1H COSY, heteronuclear multiple-quantum coherence, and heteronuclear multiple-bond coherence correlations]. The relative configurations were established by nuclear Overhauser effect spectroscopy experiments and by comparison of the NMR spectral data and coupling constants with those already reported in the literature.
authors.affiliation: Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
authors.forename: Yinggang
authors.initials: Y
authors.lastname: Luo
authors.forename: Jinhai
authors.initials: J
authors.lastname: Yi
authors.forename: Bogang
authors.initials: B
authors.lastname: Li
authors.forename: Guolin
authors.initials: G
authors.lastname: Zhang
mesh_terms: D029402:Bignoniaceae / Q000737:chemistry*; D002518:Ceramides / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: C502581:1-O-beta-D-glucopyranosyl-(2S,3S,4R,8E)-2-((2R)-2-hydroxytetracosanoylamino)-1,3,4-octodecanetriol-8-ene; D002518:Ceramides