Impact of the presence of one or more multinucleated blastomeres on the developmental potential of the embryo to the blastocyst stage.
A retrospective study of 5,982 embryos in 619 blastocyst-stage embryo transfer cycles revealed that detection of multinucleated blastomeres either on day 2 or 3 signifies a poor prognosis for blastocyst formation and that no good-quality blastocyst can be expected from an embryo with more than one multinucleated blastomere. Patients should be counseled regarding a poor prognosis when multiple embryos with multinucleated blastomeres are present.
Yakin
Kayhan
K
Assisted Reproduction Unit, American Hospital of Istanbul, Istanbul, Turkey. kayhany@amerikanhastanesi.com.tr
Balaban
Basak
B
Urman
Bulent
B
D000328:Adult; D001755:Blastocyst / Q000502:physiology*; D001757:Blastomeres / Q000502:physiology* / Q000648:ultrastructure*; D002467:Cell Nucleus / Q000648:ultrastructure*; D047108:Embryonic Development; D005260:Female; D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies