title: Treatment of atrophic vaginitis with topical conjugated equine estrogens in postmenopausal Asian women.
abstract: OBJECTIVE
  We investigated the effects of 2 months of treatment with topical estrogens on atrophic vaginitis and gynecological health in Asian women.
  
  
  METHODS
  Multicenter, open-label trial of 150 postmenopausal women age <70 years with atrophic vaginitis. Women applied conjugated equine estrogens (CEE) vaginal cream (0.625 mg/g) once daily on days 1-21 of two 28-day cycles. Changes in the vaginal maturation index (VMI) from baseline to days 21 (month 1) and 49 (month 2) were the primary outcome. Physiological changes were assessed by the Genital Health Clinical Examination (GHCE).
  
  
  RESULTS
  The VMI was significantly improved (p < 0.001) from baseline at each assessment period. The significant improvement in GHCE from baseline after 1 month (p < 0.001) was maintained at 2 months.
  
  
  CONCLUSIONS
  Vaginal treatment with CEE cream for 21 days of two consecutive 28-day cycles resulted in beneficial changes in the vaginal tissues and induced an overall genital health pattern more characteristic of the premenopausal state.
authors.affiliation: Manila Central University, Philippines.
authors.forename: N
authors.initials: N
authors.lastname: Raymundo
authors.forename: B
authors.initials: B
authors.lastname: Yu-cheng
authors.forename: H
authors.initials: H
authors.lastname: Zi-yan
authors.forename: C Huey
authors.initials: CH
authors.lastname: Lai
authors.forename: K
authors.initials: K
authors.lastname: Leung
authors.forename: R
authors.initials: R
authors.lastname: Subramaniam
authors.forename: C
authors.initials: C
authors.lastname: Bin-rong
authors.forename: Y S
authors.initials: YS
authors.lastname: Ling
authors.forename: N
authors.initials: N
authors.lastname: Nasri
authors.forename: N
authors.initials: N
authors.lastname: Calimon
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D044466:Asian People; D002681:China; D015914:Estrogen Replacement Therapy; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage*; D005260:Female; D006723:Hong Kong; D006801:Humans; D008296:Malaysia; D008875:Middle Aged; D010679:Philippines; D017698:Postmenopause; D012720:Severity of Illness Index; D012846:Singapore; D013624:Taiwan; D016896:Treatment Outcome; D014627:Vaginitis / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D016387:Women's Health
chemical_list: D004966:Estrogens, Conjugated (USP)