title: Gene duplication and complex circadian clocks in mammals.
abstract: The circadian clock arose early in the evolution of life to enable organisms to adapt to the cycle of day and night. Recently, the extent and importance of circadian regulation of behaviour and physiology has come to be more fully realized. Core molecular cogs of circadian oscillators appear to have been largely conserved between such diverse organisms as Drosophila melanogaster and mammals. However, gene duplication events have produced multiple copies of many clock genes in mammals. Recent studies suggest that genome duplication has lead to increased circadian complexity and local tissue regulation. This has important implications for temporal regulation of behaviour via multiple clocks in the central nervous system, and also extends to the local physiology of major body organs and tissues.
authors.affiliation: Faculty of Life Sciences, University of Manchester, Manchester, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Looby
authors.forename: Andrew S I
authors.initials: AS
authors.lastname: Loudon
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000235:genetics*; D004175:Diptera / Q000235:genetics; D029721:Drosophila Proteins; D020440:Gene Duplication; D008297:Male; D008322:Mammals / Q000235:genetics*; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000235:genetics; D056950:Period Circadian Proteins
chemical_list: D029721:Drosophila Proteins; D009687:Nuclear Proteins; C539040:PER protein, Drosophila; D056950:Period Circadian Proteins