Comparative analysis of accumulation of chlorine e6 and hematoporphyrin derivatives in subpopulations of peripheral blood lymphocytes.
We studied accumulation of porphyrin photosensitizers chlorine e6, hematoporphyrin, and their derivatives by different lymphocyte subpopulations. The intensity of staining of B lymphocytes and natural killer cells with photosensitizers was higher compared to T lymphocytes. T cell subpopulation differed by their ability to bind photosensitizers. Relative accumulation of dimethyl esters of chlorine e6 and hematoporphyrin in cells surpassed that of nonesterified porphyrins.
Savitskii
V P
VP
Republican Research-and-Production Center for Child Oncology and Hematology, Minsk. savitskiy_v@yahoo.com
Zorin
V P
VP
Potapnev
M P
MP
Potapenko
A Ya
AY
D016175:B-Lymphocyte Subsets / Q000378:metabolism; D002735:Chlorophyllides; D017324:Hematoporphyrin Derivative / Q000378:metabolism*; D006414:Hematoporphyrin Photoradiation; D006801:Humans; D016131:Lymphocyte Subsets / Q000378:metabolism*; D011166:Porphyrins / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000378:metabolism
D002735:Chlorophyllides; D011166:Porphyrins; C062985:phytochlorin; D017324:Hematoporphyrin Derivative