Activating effect of Tanacetum vulgare L. pectin polysaccharide on ionic channels of neuronal membrane.
The membranotropic effects of TVF tanacetan pectin polysaccharide derived from Tanacetum vulgare L. was studied by the voltage-clamp method on isolated neurons of Lymnaea stagnalis mollusk. TVF in concentrations of 0.1-10.0 microg/ml nonselectively activated the outward potassium and total inward (sodium and calcium) ionic currents (slightly dose-dependently and reversibly increased their amplitude by 5-10%) and decreased nonspecific leakage current.
Vislobokov
A I
AI
Institute of Physiology, Komi Research Center, Ural Division of Russian Academy of Sciences, Syktyvkar.
Prosheva
V I
VI
Polle
A Ya
AY
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism*; D007700:Kinetics; D008195:Lymnaea; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism*; D010368:Pectins / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D031203:Tanacetum
D007473:Ion Channels; D010368:Pectins; D011188:Potassium