title: Aurantosides G, H, and I: three new tetramic acid glycosides from a Papua New Guinea Theonella swinhoei.
abstract: Aurantosides G-I (1-3) have been isolated from the lithistid sponge Theonella swinhoei from Papua New Guinea. Their structures were established by spectroscopic and chemical methods. Compounds 1-3 represent new monochloropentaenoyl tetramic acids with mono-, di-, and tri-N-saccharide substituents, respectively. Aurantosides G-I (1-3) failed to show any significant cytotoxicity against the human colon tumor cell line HCT-116.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
authors.forename: Anokha S
authors.initials: AS
authors.lastname: Ratnayake
authors.forename: Rohan A
authors.initials: RA
authors.lastname: Davis
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Harper
authors.forename: Charles A
authors.initials: CA
authors.lastname: Veltri
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Andjelic
authors.forename: Louis R
authors.initials: LR
authors.lastname: Barrows
authors.forename: Chris M
authors.initials: CM
authors.lastname: Ireland
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D011161:Porifera / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D011760:Pyrrolidinones; C498132:aurantoside G; C498134:aurantoside H; C498133:aurantoside I