title: [Back to the future: pathophysiology and therapeutic strategies in heart failure].
abstract: The present paper reviews the pathophysiology and therapeutic strategies in heart failure based on clinical investigations performed in our institute, and also recently reported large-scale double-blind clinical trials for the medical treatments of heart failure. Careful introduction of beta-blocker therapy along with RAAS inhibitors (ACE inhibitor, ARB, and/or aldosterone antagonist) should bring about marked improvement in mortality and morbidity in all subgroups of patients with heart failure.
authors.affiliation: First Department of Internal Medicine, Nippon Medical School, Tokyo 113-8603, Japan. y-seino@nms.ac.jp
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Seino
mesh_terms: D002908:Chronic Disease; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans