TRKing signals through the Golgi.
The subcellular localization of transmembrane receptors and other signaling proteins has emerged as a key component in the regulation of the intensity and specificity of their activity. Recent research indicates that immature TrkA neurotrophin receptors are transactivated in the Golgi apparatus after stimulation of neuropeptide pituitary adenylate cyclase-activating polypeptide PAC1 receptors or adenosine A(2A) receptors. Transactivation occurs independently of the TrkA extracellular ligand, nerve growth factor (NGF), through a signaling pathway that is distinct from that used in the transactivation of other receptor tyrosine kinases and has consequences distinct from those elicited by NGF at the plasma membrane.
Sorkin
Alexander
A
Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80045-3649, USA. Alexander.sorkin@uchsc.edu <Alexander.sorkin@uchsc.edu>
D000225:Adenine / Q000494:pharmacology; D000818:Animals; D011992:Endosomes / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology*; D020962:Heterotrimeric GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000494:pharmacology; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D051381:Rats; D020917:Receptor, trkA / Q000187:drug effects / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects
D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D043562:Receptors, G-Protein-Coupled; D020917:Receptor, trkA; D020962:Heterotrimeric GTP-Binding Proteins; D000225:Adenine