Transport regulation by the serum- and glucocorticoid-inducible kinase SGK1.
The serum- and glucocorticoid-inducible kinase SGK1 is an ubiquitously expressed kinase with the ability to regulate a variety of transport systems. Recent observations point to a role of SGK1 in the regulation of diverse physiological functions such as epithelial transport and cardiac and neuronal excitability. At least partially through its effect on transport, SGK1 contributes to a number of pathophysiological conditions including metabolic syndrome and fibrosing disease.
Lang
F
F
Department of Physiology, Eberhard-Karls-University of Tuebingen, Gmelinstrasse 5, D-72076 Tuebingen, Germany. florian.lang@uni-tuebingen.de
Vallon
V
V
Grahammer
F
F
Palmada
M
M
Böhmer
C
C
D001692:Biological Transport / Q000502:physiology*; D004789:Enzyme Activation; D017874:Immediate-Early Proteins; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D000099184:Serum-Glucocorticoid Regulated Kinases
D017874:Immediate-Early Proteins; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; D000099184:Serum-Glucocorticoid Regulated Kinases