Oral bexarotene in a therapy-resistant Sézary syndrome patient: observations on Sézary cell compartmentalization.
BACKGROUND
A 63-year-old man with therapy-resistant Sézary syndrome was enrolled in a multicenter trial of oral bexarotene for advanced-stage cutaneous T-cell lymphoma (CTCL).


METHODS
Monthly evaluations for efficacy and side-effects were conducted and documented.


RESULTS
Gradual improvement in erythema, pruritus, and scale was noted during the initial 16-week trial period and treatment was extended to 40 weeks. From week 20 to week 40, the erythroderma continued to improve and the lymph node burden decreased, but the absolute Sézary cell count inversely increased. By week 40, intractable pruritus and erythroderma abruptly recurred, and bexarotene was discontinued.


CONCLUSIONS
Bexarotene is well tolerated and can be efficacious in patients with Sézary syndrome. Shifting of Sézary cells between different compartments was noted. Further studies on the interaction between the skin, lymph nodes, and peripheral blood compartments during bexarotene treatment in this subset of patients with CTCL are needed.
el-Azhary
Rokea A
RA
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA. elazhary.rokea2@mayo.edu
Bouwhuis
Saskia A
SA
D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077610:Bexarotene; D003873:Dermatitis, Exfoliative / Q000473:pathology; D004890:Erythema / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000473:pathology; D047488:Retinoid X Receptors / Q000819:agonists; D012751:Sezary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D047488:Retinoid X Receptors; D013764:Tetrahydronaphthalenes; D000077610:Bexarotene