title: Early events in antigen-specific regulatory T cell induction via nasal and oral mucosa.
abstract: Mucosal Tr prevent harmful immune responses to innocuous antigens that are encountered at the mucosae. This unique subset of Tr is adaptive, antigen specific, and suppresses irrespective of cytokine polarization. Here we study the earliest events of mucosal Tr induction and factors that control their differentiation from naive T cells.
authors.affiliation: Department of Molecular Cell Biology and Immunology, VUMC, FdG, P.O. Box 7057, 1007 MB, Amsterdam, the Netherlands. jn.samsom@vumc.nl
authors.forename: Janneke N
authors.initials: JN
authors.lastname: Samsom
authors.forename: Femke
authors.initials: F
authors.lastname: Hauet-Broere
authors.forename: Wendy W J
authors.initials: WW
authors.lastname: Unger
authors.forename: Lisette A
authors.initials: LA
authors.lastname: VAN Berkel
authors.forename: Georg
authors.initials: G
authors.lastname: Kraal
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000276:immunology*; D002454:Cell Differentiation; D018928:Immunity, Mucosal / Q000276:immunology*; D007273:Injections, Intramuscular; D008198:Lymph Nodes / Q000276:immunology; D009061:Mouth Mucosa / Q000276:immunology*; D009297:Nasal Mucosa / Q000276:immunology*; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000941:Antigens; D010047:Ovalbumin