title: Dialyzable carbosilane dendrimers as soluble supports for the functionalization of pyridine fragments via palladium-catalyzed coupling reactions.
abstract: [reaction: see text] The use of carbosilane (CS) dendrimers as soluble supports in liquid phase organic synthesis (LPOS) is described. Control of the three key steps is perfectly achieved by covalently binding a pyridine fragment to the soluble support, modifying it via coupling reactions, and releasing it at the end. Nanofiltration (dialysis) allows facile purification of the supported molecules after each step.
authors.affiliation: Debye Institute, Department of Metal-Mediated Synthesis and Homogeneous Catalysis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Le Nôtre
authors.forename: Judith J
authors.initials: JJ
authors.lastname: Firet
authors.forename: Leo A J M
authors.initials: LA
authors.lastname: Sliedregt
authors.forename: Bart J
authors.initials: BJ
authors.lastname: van Steen
authors.forename: Gerard
authors.initials: G
authors.lastname: van Koten
authors.forename: Robertus J M
authors.initials: RJ
authors.lastname: Klein Gebbink
mesh_terms: D002384:Catalysis; D050091:Dendrimers; D003956:Dialysis; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D012995:Solubility; D014297:Trimethylsilyl Compounds / Q000737:chemistry
chemical_list: D050091:Dendrimers; D011725:Pyridines; D012821:Silanes; D014297:Trimethylsilyl Compounds; C504072:carbosilane; D010165:Palladium