title: Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay.
abstract: Intestinal injury that results from chemotherapy belongs to the major factors of dose-limitation in tumour therapy. The tyrphostins AG1714 and AG1801 reduce cisplatin and 5-FU-induced small intestinal mucosal damage, using a quantitative biochemical assay. The assay is based on the determination of the enzymatic activity of gamma-glutamyl transpeptidase, a marker of the brush border epithelium of the small intestine.
authors.affiliation: Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Rabin Medical Center, Beilinson Campus, Petah-Tikva 49100, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Zlotnik
authors.forename: M
authors.initials: M
authors.lastname: Patya
authors.forename: A
authors.initials: A
authors.lastname: Vanichkin
authors.forename: A
authors.initials: A
authors.lastname: Novogrodsky
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects; D007410:Intestinal Diseases / Q000139:chemically induced / Q000517:prevention & control*; D007413:Intestinal Mucosa / Q000187:drug effects*; D051379:Mice; D020032:Tyrphostins / Q000627:therapeutic use*; D005723:gamma-Glutamyltransferase / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D020032:Tyrphostins; D005723:gamma-Glutamyltransferase; D002945:Cisplatin; D005472:Fluorouracil