title: How to study boron biodistribution in liver metastases from colorectal cancer.
abstract: The purpose of this study was to evaluate boron distribution for a safe and effective BNCT (Boron Neutron Capture Therapy) of liver metastases. Samples both from healthy and tumour liver parenchyma were analysed, after i.v. boron administration, by: alpha particles counting under neutron irradiation; morphological analysis by standard haematoxylin-eosin staining; neutron autoradiography. Our method was unaffected by the cytological heterogeneity inside tumour nodules; it demonstrated selective boron distribution in tumour tissue and predicted estimated mean therapeutic doses in tumour and safety doses in healthy tissue. The time interval for efficient BNCT was 2 to 4 hours after i.v. boron administration.
authors.affiliation: Hepato-Pancreatic Surgery, IRCCS Pol S Matteo, Pavia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Roveda
authors.forename: U
authors.initials: U
authors.lastname: Prati
authors.forename: J
authors.initials: J
authors.lastname: Bakeine
authors.forename: F
authors.initials: F
authors.lastname: Trotta
authors.forename: P
authors.initials: P
authors.lastname: Marotta
authors.forename: P
authors.initials: P
authors.lastname: Valsecchi
authors.forename: A
authors.initials: A
authors.lastname: Zonta
authors.forename: R
authors.initials: R
authors.lastname: Nano
authors.forename: A
authors.initials: A
authors.lastname: Facoetti
authors.forename: P
authors.initials: P
authors.lastname: Chiari
authors.forename: S
authors.initials: S
authors.lastname: Barni
authors.forename: T
authors.initials: T
authors.lastname: Pinelli
authors.forename: S
authors.initials: S
authors.lastname: Altieri
authors.forename: A
authors.initials: A
authors.lastname: Braghieri
authors.forename: P
authors.initials: P
authors.lastname: Bruschi
authors.forename: F
authors.initials: F
authors.lastname: Fossati
authors.forename: P
authors.initials: P
authors.lastname: Pedroni
mesh_terms: D000818:Animals; D001895:Boron / Q000493:pharmacokinetics*; D016754:Boron Neutron Capture Therapy; D015179:Colorectal Neoplasms / Q000473:pathology*; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D008297:Male; D051381:Rats; D014018:Tissue Distribution
chemical_list: D001895:Boron