Emerging role of cyclic ADP-ribose (cADPR) in smooth muscle.
Cyclic adenosine diphosphate ribose (cADPR) is a naturally occurring cyclic nucleotide and represents a novel class of endogenous Ca(2+) messengers implicated in the regulation of the gating properties of ryanodine receptors (RyRs). This action of cADPR occurs independently from the inositol-1,4,5-trisphosphate (IP(3)) receptor. The regulation of intracellular Ca(2+) release is a fundamental element of cellular Ca(2+) homeostasis since a number of smooth muscle functions (tone, proliferation, apoptosis, and gene expression) are modulated by intracellular Ca(2+) concentration ([Ca(2+)](i)). There has been a surge in the efforts aimed at understanding the mechanisms of cADPR-mediated Ca(2+) mobilization and its impact on smooth muscle function. This review summarizes the proposed roles of cADPR in the regulation of smooth muscle tone.
Bai
Ni
N
Department of Pharmacology and Therapeutics, University of British Columbia Vancouver, BC, Canada V6T 1Z3.
Lee
Hon Cheung
HC
Laher
Ismail
I
D000818:Animals; D002118:Calcium / Q000378:metabolism; D036563:Cyclic ADP-Ribose / Q000502:physiology*; D009130:Muscle, Smooth / Q000201:enzymology*; D015398:Signal Transduction
D036563:Cyclic ADP-Ribose; D002118:Calcium