Evaluation of in vivo biological activity profile of isoorientin.
Anti-nociceptive, anti-inflammatory and gastroprotective activities of the known C-glycosyl flavonoid, isoorientin, were studied in rats and mice. For the anti-nociceptive activity assessment the p-benzoquinone-induced writing test, for the anti-inflammatory activity the carrageenan-induced hind paw edema model in mice, and for the gastroprotective activity the EtOH-induced ulcerogenesis model in rats were used. Isoorientin was shown to possess significant anti-nociceptive and anti-inflammatory activities at 15 mg/kg and 30 mg/kg doses, without inducing any apparent acute toxicity as well as gastric damage. However, the compound did not possess any significant gastroprotective activity against EtOH-induced ulcerogenesis.
Küpeli
Esra
E
Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Etiler, 06330 Ankara, Turkey.
Aslan
Mustafa
M
Gürbüz
Ilhan
I
Yesilada
Erdem
E
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D030012:Gentiana / Q000737:chemistry*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D047311:Luteolin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015394:Molecular Structure
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; C057912:homoorientin; D047311:Luteolin