[Study on the pharmacological mechanism of sodium ferulate for anti-asthmatic effect in guinea pigs].
OBJECTIVE
To study the anti-asthmatic effect of sodium ferulate (SF) and its mechanism in guinea pig asthmatic model.


METHODS
Guinea pigs were sensitized with ovalbumin as animal asthmatic model and treated with 3 different concentration of SF for 8 days. Levels of endothelin (ET) and nitric oxide (NO) in blood and lung tissue, and eosinophil (EOS) in blood and bronchoalveolar lavage fluid (BLAF) was counted at the end of trial.


RESULTS
SF could significantly lower the ET content and increase the NO concentration in serum and lung tissue, reduce the number of EOS in blood and BLAF (P < 0.05, P < 0.01). Stronger effect was showed in the high dose group.


CONCLUSIONS
Mechanism of anti-asthmatic action of SF might be to increase NO concentration, lower ET content, alleviate EOS infiltration.
Sun
Yun
Y
Hong-quan Medical College of Yangzhou University, Yangzhou, Jiangsu 225001.
Xu
Feng
F
Zhang
Hong-Quan
HQ
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D001249:Asthma / Q000097:blood / Q000139:chemically induced; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D003373:Coumaric Acids / Q000494:pharmacology*; D019332:Endothelin-1 / Q000097:blood; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D010047:Ovalbumin
D018927:Anti-Asthmatic Agents; D003373:Coumaric Acids; D019332:Endothelin-1; D009569:Nitric Oxide; D010047:Ovalbumin; C004999:ferulic acid