Transforming growth factor-{beta} regulates susceptibility of epithelial apoptosis in murine model of colitis.
Transforming growth factor (TGF)-beta has a key role in intestinal homeostasis. Our present data suggest that TGF-beta, which was constitutively expressed by lamina propria mononuclear cells and epithelium, affected epithelial cells. Abnormal suppression of TGF-beta could enhance the sensitivity of epithelial cells to apoptosis associated with interferon-gamma in DSS-induced colitis.
Sakuraba
Hirotake
H
First Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan. hirotake@infoaomori.ne.jp
Ishiguro
Yoh
Y
Yamagata
Kazufumi
K
Tagawa
Yoh-Ichi
Y
Iwakura
Yoichiro
Y
Sekikawa
Kenji
K
Munakata
Akihiro
A
Nakane
Akio
A
D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology*; D051379:Mice; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016212:Transforming Growth Factor beta; D016264:Dextran Sulfate