Regulation of tumor cell motility by ERK mitogen-activated protein kinases.
Metastasis is the main cause of human cancer deaths, and cell motility is one key component of the process of metastasis. The ERK mitogen-activated protein kinase (MAPK) signaling pathway is probably one of the most commonly activated in malignant human cancers. We describe the molecular mechanisms by which ERK MAPK signaling regulates cell motility and its importance for cancer cell dissemination.
Viala
Emmanuel
E
Institute of Signaling Developmental Biology and Cancer, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6543, Centre Antoine Lacassagne, 33 avenue de Valombrose, 06189 Nice, France. evial@unice.fr
Pouysségur
Jacques
J
D002448:Cell Adhesion; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009362:Neoplasm Metastasis
D020928:Mitogen-Activated Protein Kinases