title: Use of mifepristone to ripen the cervix and induce labor in term pregnancies.
abstract: OBJECTIVE
  This study was undertaken to determine the efficacy of mifepristone for ripening the cervix and inducing labor in term pregnancies.
  
  
  METHODS
  In a double-blind placebo-controlled dose-finding study, 346 women received 50, 100, 200, 400, or 600 mg of mifepristone or placebo. The main endpoint for efficacy was the number of patients in whom labor occurred between 12 and 45 and 54 hours after treatment or who had a Bishop score 6 or greater. Maternal and fetal tolerability was also studied.
  
  
  RESULTS
  No significant efficacy was observed whatever the dose of mifepristone. Mifepristone was well tolerated by the mother and fetus.
  
  
  CONCLUSIONS
  Mifepristone, at doses up to 600 mg, does not induce labor within 54 hours in patients with unfavourable cervical status.
authors.affiliation: Department of Gynecology-Obstetrics and Reproductive Medicine, Hôpital Tenon, Paris, France. nadia.berkane@tnn.ap-hop-paris.fr
authors.forename: Nadia
authors.initials: N
authors.lastname: Berkane
authors.forename: Lieve
authors.initials: L
authors.lastname: Verstraete
authors.forename: Serge
authors.initials: S
authors.lastname: Uzan
authors.forename: Georges
authors.initials: G
authors.lastname: Boog
authors.forename: Bernard
authors.initials: B
authors.lastname: Maria
mesh_terms: D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage*; D000284:Administration, Oral; D000328:Adult; D020070:Cervical Ripening; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007751:Labor, Induced; D015735:Mifepristone / Q000008:administration & dosage*; D011247:Pregnancy; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000021:Abortifacient Agents, Steroidal; D015735:Mifepristone