title: Invasive ductal carcinoma of the breast with a large central acellular zone associated with matrix-producing carcinoma.
abstract: Matrix-producing carcinoma is a variant of metaplastic carcinoma of the breast that consists of overt carcinoma with direct transition to a cartilagenous and osseous stromal matrix. A clinicopathological association between MPC and high-grade invasive ductal carcinoma with a large central acellular zone has been recently discussed. However, few reports have ever shown the radiological, pathological and immunohistochemical correlation of this unique tumor. We present a case of 27-year-old woman with matrix-producing carcinoma with a large central acellular zone, which was characterized by a large homogeneous hypodense center with well-marginated, ring-like enhancement on contrast enhanced computerized tomography.
authors.affiliation: Department of Radiology, National Defense Medical College, Namiki, Tokorozawa, Saitama, Japan. yjhama@me.ndmc.ac.jp
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Hama
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tsuda
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sato
authors.forename: Hoshio
authors.initials: H
authors.lastname: Hiraide
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Mochizuki
authors.forename: Shoichi
authors.initials: S
authors.lastname: Kusano
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005109:Extracellular Matrix / Q000473:pathology; D005260:Female; D006801:Humans; D008679:Metaplasia; D011859:Radiography