Peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists have minimal effects on the interaction of endothelial cells with Plasmodium falciparum-infected erythrocytes.
Peroxisome proliferator-activated receptor gamma-retinoid X receptor (PPARgamma-RXR) agonists had minimal effects on the surface levels of CD36, intercellular cell adhesion molecule-1, or platelet-endothelial cell adhesion molecule-1 and had no effect on the cytoadherence of infected erythrocytes to either human umbilical vein endothelial cells or human microvascular endothelial cells or on malaria-induced interleukin-6 secretion from these cells. PPARgamma-RXR agonists do not significantly modify malaria-infected erythrocyte-endothelial cell interactions in vitro.
Serghides
Lena
L
Toronto General Hospital, 200 Elizabeth St. 9ES-412, Toronto, Ontario, M5G 2C4 Canada.
Kain
Kevin C
KC
D000818:Animals; D015415:Biomarkers; D002448:Cell Adhesion / Q000502:physiology; D042783:Endothelial Cells / Q000502:physiology*; D004912:Erythrocytes / Q000469:parasitology* / Q000502:physiology; D005434:Flow Cytometry; D006801:Humans; D047495:PPAR gamma / Q000819:agonists*; D010963:Plasmodium falciparum; D047488:Retinoid X Receptors / Q000819:agonists*
D015415:Biomarkers; D047495:PPAR gamma; D047488:Retinoid X Receptors