title: [A case of oropharyngeal cancer with multiple bone metastases from prostate cancer that responded to docetaxel, ifosfamide and cisplatin combination therapy].
abstract: We encountered an oropharyngeal cancer patient with multiple bone metastases from prostate cancer who achieved a partial response to 3 cycles of combination chemotherapy including docetaxel, ifosfamide and cisplatin (DIP). A 72-year-old man was found to have advanced oropharyngeal cancer during hormonal treatment of bone metastases from prostate cancer. Combination chemotherapy was initiated with DIP. After chemotherapy, computed tomography revealed no residual tumor at the oropharyngeal region, but a small ulcer was seen at the base of the tongue by laryngopharyngoscopy. The patient obtained a partial response after 3 cycles of this regimen. During chemotherapy the patient could take oral meals because of no stomatitis. After chemotherapy the patient received radiation therapy (60 Gy/30 f). The oropharyngeal cancer disappeared completely after radiotherapy. It is suggested that combination chemotherapy with DIP is a potential new treatment modality for advanced head and neck cancer.
authors.affiliation: Dept of Otolaryngology, Keiyukai Sapporo Hospital.
authors.forename: Akihito
authors.initials: A
authors.lastname: Watanabe
authors.forename: Masanobu
authors.initials: M
authors.lastname: Taniguchi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D004334:Drug Administration Schedule; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007262:Infusions, Intravenous; D008297:Male; D009959:Oropharyngeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy; D011471:Prostatic Neoplasms / Q000473:pathology*; D011788:Quality of Life; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D007069:Ifosfamide