title: Differential immune induction with subcutaneous versus oral administration of a diabetogenic insulin peptide in the NOD mouse.
abstract: The B chain insulin peptide 9 to 23 (B:9-23) is a dominant T cell epitope of the NOD mouse. Given in oral form with multiple different vehicles, it did not alter expression of insulin autoantibodies in contrast to subcutaneous administration.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
authors.forename: Devasenan
authors.initials: D
authors.lastname: Devendra
authors.forename: Johanna
authors.initials: J
authors.lastname: Paronen
authors.forename: Edwin
authors.initials: E
authors.lastname: Liu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Moriyama
authors.forename: Dongmei
authors.initials: D
authors.lastname: Miao
authors.forename: Liping
authors.initials: L
authors.lastname: Yu
authors.forename: George S
authors.initials: GS
authors.lastname: Eisenbarth
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D018928:Immunity, Mucosal; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage* / Q000276:immunology; D051379:Mice; D016688:Mice, Inbred NOD; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007328:Insulin; D010446:Peptide Fragments; C097877:insulin B (9-23)