A structure-taste study of arylsulfonyl(cyclo)alkanecarboxylic acids.
A number of sweeteners contain a sulfonyl group. In our current search for new glucophores several new compounds containing such group were obtained. A series of novel 1-phenylsulfonylcyklohexanecarboxylic acids and 2-arylsulfonylalkanecarboxylic acids was obtained and evaluated for their sweet taste quality. It has been found that methyl substituents are of the key importance for the activity of these compounds.
Lysiak
Violetta
V
Department of Organic Chemistry, Institute of Chemistry, University of Silesia, PL-40-006 Katowice, Poland.
Ratajczak
Aleksander
A
Mencel
Agnieszka
A
Jarzembek
Krystyna
K
Polanski
Jaroslaw
J
D002264:Carboxylic Acids / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013329:Structure-Activity Relationship; D013549:Sweetening Agents / Q000737:chemistry* / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects*
D002264:Carboxylic Acids; D013549:Sweetening Agents