title: pH-Switchable strand orientation in peptide assemblies.
abstract: [structure: see text] The design of antiparallel coiled-coil heterotrimers with singly mismatched electrostatic interfaces is reported. The new complexes exhibit expected properties for well-formed coiled-coils and have stabilities comparable to those of parallel analogues. The mismatched interface facilitates switching from a parallel to antiparallel complex by pH-triggered strand exchange.
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Schnarr
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Kennan
mesh_terms: D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D004220:Disulfides / Q000737:chemistry; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D004220:Disulfides; D010455:Peptides