title: CSF-chemokines in HTLV-I-associated myelopathy: CXCL10 up-regulation and therapeutic effect of interferon-alpha.
abstract: We measured four chemokines in the cerebrospinal fluid (CSF) in human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with ELISA. CXCL10/IP-10, a T cell type 1 (Th1)-associated chemokine, was significantly elevated in HAM/TSP compared with controls, and the values were even significantly higher in HAM/TSP than in multiple sclerosis (MS) in which CXCL10/IP-10 up-regulation was previously reported. Among Th2-associated chemokines, CCL17/TARC and CCL11/Eotaxin in HAM/TSP were not different from those in controls. As shown in MS, CCL2/MCP-1 was significantly lower in HAM/TSP than in control. Following interferon (IFN)-alpha therapy in HAM/TSP, CCL2/MCP-1 became significantly higher than that before therapy, which may reflect a Th2 induction, while CXCL10/IP-10 remained elevated.
authors.affiliation: Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai 980-8574, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Narikawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Fujihara
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Misu
authors.forename: Juan
authors.initials: J
authors.lastname: Feng
authors.forename: Juichi
authors.initials: J
authors.lastname: Fujimori
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakashima
authors.forename: Isabelle
authors.initials: I
authors.lastname: Miyazawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saito
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sato
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Itoyama
mesh_terms: D000328:Adult; D000368:Aged; D054413:Chemokine CCL11; D054414:Chemokine CCL17; D018932:Chemokine CCL2 / Q000096:biosynthesis / Q000097:blood / Q000134:cerebrospinal fluid; D054357:Chemokine CXCL10; D019742:Chemokines, CC / Q000097:blood / Q000134:cerebrospinal fluid; D019743:Chemokines, CXC / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology / Q000628:therapy; D015493:Paraparesis, Tropical Spastic / Q000134:cerebrospinal fluid* / Q000276:immunology* / Q000628:therapy; D011933:Reagent Kits, Diagnostic; D015854:Up-Regulation / Q000276:immunology*
chemical_list: C515456:CCL11 protein, human; C106230:CCL17 protein, human; D054413:Chemokine CCL11; D054414:Chemokine CCL17; D018932:Chemokine CCL2; D054357:Chemokine CXCL10; D019742:Chemokines, CC; D019743:Chemokines, CXC; D016898:Interferon-alpha; D011933:Reagent Kits, Diagnostic