A new bactericidal lead structure for the protection of materials.
Our search for a new broad spectrum bactericide for preserving materials lead to the discovery of a highly active bicyclic amine (1) and a number of derivatives. The synthesis and biological evaluation as well as a first toxicological assessment of these compounds are described. Compound 1 shows strong bactericidal activity down to levels of below 100 ppm but unfortunately increases the number of mutations in Ames tests.
Vogl
Erasmus
E
Bayer Chemicals AG, Material Protection Products, BCH-R and D, Geb. I1, 51368 Leverkusen, Germany. erasmus.vogl.ev@bayerchemicals.com
Bruns
Rainer
R
Kretschik
Oliver
O
Uhr
Hermann
H
Kaulen
Johannes
J
Kugler
Martin
M
Wachtler
Peter
P
Kreiss
Wolfgang
W
Eberz
Günther
G
D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000494:pharmacology; D004202:Disinfectants / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000588:Amines; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004202:Disinfectants