Lack of evidence for genetic association to RUNX1 binding site at PSORS2 in different German psoriasis cohorts.
A DNA variant, rs734232, altering a RUNX1 binding site was recently reported as susceptibility allele at PSORS2 (17q25) in cohorts of psoriasis patients from the US. A testing of this variant in psoriasis patients from Germany did not confirm this association in 300 trios nor in two case-control studies with 281 patients with psoriasis vulgaris and 375 patients with psoriatic arthritis, respectively. These results fail to support rs734232 as a psoriasis susceptibility factor in German psoriasis patients.
Hüffmeier
Ulrike
U
Institute of Human Genetics, University Erlangen-Nuremberg, Nuremberg, Germany.
Traupe
Heiko
H
Burkhardt
Harald
H
Schürmeier-Horst
Funda
F
Lascorz
Jesus
J
Böhm
Beate
B
Lohmann
Jörg
J
Ständer
Markward
M
Wendler
Jörg
J
Kelsch
Reinhard
R
Baumann
Claudia
C
Küster
Wolfgang
W
Wienker
Thomas F
TF
Reis
André
A
D000293:Adolescent; D000328:Adult; D015535:Arthritis, Psoriatic / Q000453:epidemiology / Q000235:genetics*; D001665:Binding Sites / Q000235:genetics; D016022:Case-Control Studies; D002886:Chromosomes, Human, Pair 17; D002896:Chromosomes, Human, Pair 6; D015331:Cohort Studies; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics*
D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C493728:RUNX1 protein, human; D014157:Transcription Factors