The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target.
Here we show that human papillomavirus (HPV) E6 and E7 oncoproteins induce hWAPL expression. In addition, small interfering RNA (siRNA) of hWAPL suppressed the growth of tumours derived from SiHa cells in nude mice. Thus, hWAPL may be one of the effective targets of uterine cervical cancer therapy.
Kuroda
M
M
Department of Pathology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-8402, Japan. kuroda@tokyo-med.ac.jp
Kiyono
T
T
Oikawa
K
K
Yoshida
K
K
Mukai
K
K
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D015151:Immunoblotting; D051379:Mice; D009687:Nuclear Proteins; D015513:Oncogene Proteins / Q000235:genetics*; D009856:Oncogene Proteins, Viral / Q000187:drug effects*; D027383:Papillomaviridae / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D034741:RNA, Small Interfering / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*; D000097722:Cohesins
D002352:Carrier Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D034741:RNA, Small Interfering; C488092:WAPL protein, human; D000097722:Cohesins