New approaches to the formation of a stationary phase in an immunoadsorption wall.
The concept of an immunoadsorption wall, which combines the principles of immunoisolation and immunoadsorption, was proposed in 1999 to remove certain toxins accumulated in patients' blood. However, realization of this concept is obviously handicapped by the inefficient use of immunoadsorbent. This study is intended to improve the use of immunoadsorbent and optimize the formation of a stationary phase in an immunoadsorption wall. Polyacrylamide gel, which has the advantages of being chemically inert, having minimal diffusion effect and reasonable cost, could be considered as the medium of choice for a stationary phase. In this study, new approaches aimed at effective allocation of immunoadsorbent utilizing polyacrylamide gel are attempted. The advantages and disadvantages of these new approaches are discussed according to the preparation, formation, and outcome of a stationary phase. It is hoped that these new approaches could serve as a first step toward building an immunoadsorption wall.
Yang
Tsung-Hua
TH
Department of Chemical Engineering, Cheng Shiu University, Kaohsiung, Taiwan, Republic of China. thyang@csu.edu.tw
D000180:Acrylic Resins / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000494:pharmacology*; D003956:Dialysis / Q000295:instrumentation*; D005240:Feasibility Studies; D006801:Humans; D007163:Immunosorbent Techniques / Q000295:instrumentation*; D008567:Membranes, Artificial; D051437:Renal Insufficiency / Q000628:therapy
D000180:Acrylic Resins; D001672:Biocompatible Materials; D008567:Membranes, Artificial; C016680:polyacrylamide gels