title: PipPhos and MorfPhos: privileged monodentate phosphoramidite ligands for rhodium-catalyzed asymmetric hydrogenation.
abstract: A library of 20 monodentate phosphoramidite ligands has been prepared and applied in rhodium-catalyzed asymmetric hydrogenation. This resulted in the identification of two ligands, PipPhos and MorfPhos, that afford excellent and in several cases unprecedented enantioselectivities in the hydrogenation of N-acyldehydroamino acid esters, dimethyl itaconate, acyclic N-acylenamides, and cyclic N-acylenamides. In addition, a method for the parallel enantioselectivity determination of eight acylated amines is presented.
authors.affiliation: Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Heiko
authors.initials: H
authors.lastname: Bernsmann
authors.forename: Michel
authors.initials: M
authors.lastname: van den Berg
authors.forename: Rob
authors.initials: R
authors.lastname: Hoen
authors.forename: Adriaan J
authors.initials: AJ
authors.lastname: Minnaard
authors.forename: Gerlinde
authors.initials: G
authors.lastname: Mehler
authors.forename: Manfred T
authors.initials: MT
authors.lastname: Reetz
authors.forename: Johannes G
authors.initials: JG
authors.lastname: De Vries
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa