Cutaneous tumors as the initial presentation of non-T, non-B, nonmyeloid CD4+ CD56+ hematolymphoid malignancy in an adolescent boy.
We describe a 14-year-old Hispanic boy who presented with a 2-month history of enlarging plum-colored cutaneous tumors on his face, trunk, and proximal extremities. Histopathologic examination showed nodular infiltrates of malignant mononuclear cells extending from the superficial dermis to the deep subcutis. Immunohistochemical staining of the biopsy specimen and flow cytometry studies on a bone marrow aspirate revealed a CD4+, CD56+ hematolymphoid tumor that was negative for all other myeloid and lymphoid markers. Based on this information, the patient was diagnosed with the recently described, rare non-T, non-B, nonmyeloid CD4+ CD56+ hematolymphoid malignancy. To our knowledge, this is the youngest patient reported in the literature.
Fass
Jonathan
J
Department of Medicine, Division of Dermatology, University of Texas Health Science Center at San Antonio, TX 78229-3900, USA.
Tichy
Elizabeth H
EH
Kraus
Eric W
EW
Herrick
Jennifer L
JL
Ehsan
Aamir
A
Peterson
Joe
J
Grimwood
Ronald E
RE
D000293:Adolescent; D015704:CD4 Antigens / Q000276:immunology; D019002:CD56 Antigen / Q000276:immunology; D019337:Hematologic Neoplasms / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*
D015704:CD4 Antigens; D019002:CD56 Antigen