title: Gamma knife surgery for multiple hemangioblastomas.
abstract: OBJECTIVE
  The authors describe their experience in treating patients with hemangioblastoma, especially multiple lesions, with gamma knife surgery (GKS).
  
  
  METHODS
  Nine patients with 84 hemangioblastomas underwent GKS between July 1992 and May 2003. Three patients harbored a single lesion and six patients had multiple lesions. Of the six patients with multifocal tumors, a diagnosis of von Hippel-Lindau disease had been established in five. In the patients with multiple lesions, the mean radiation dose delivered to the tumor margin was 16.6 Gy (range 12.8-29.75 Gy). The mean margin isodose was 60% (range 40-95%). Three of the 84 lesions failed to be controlled after a mean follow-up period of 4.3 years (range 8.6-141 months). One patient who had undergone two GKS treatments suffered delayed radiation-induced complications, and posterior fossa decompression and ventriculoperitoneal shunt insertion were required.
  
  
  CONCLUSIONS
  To achieve tumor control and avoid morbidity, the surgeon should keep in mind minimizing field overlapping by using a small-diameter collimator or applying a steep dose gradient, and by accurate dose prescription.
authors.affiliation: Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Yong Sook
authors.initials: YS
authors.lastname: Park
authors.forename: Jong Hee
authors.initials: JH
authors.lastname: Chang
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Chang
authors.forename: Sang Sup
authors.initials: SS
authors.lastname: Chung
authors.forename: Yong Gou
authors.initials: YG
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D018325:Hemangioblastoma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D016634:Radiosurgery / Q000295:instrumentation*; D006623:von Hippel-Lindau Disease / Q000175:diagnosis / Q000601:surgery