Genetic selection for resistance or susceptibility to oral tolerance to ovalbumin affects general mechanisms of tolerance induction in mice.
To study the genes involved in oral tolerance susceptibility, two strains of mice were genetically selected for susceptibility (TS) and resistance (TR) to oral tolerance to ovalbumin by bidirectional breeding. Herein we show that the genetic selection process is restricted neither to ovalbumin nor to oral tolerance. It affected oral tolerance to other proteins, such as casein, and tolerance induced the intravenous route.
Kamphorst
Alice O
AO
Laboratório de Imunobiologia, Departamento de Bioquímica e Imunologia, ICB-UFMG, Av. Antônio Carlos, 6627 Pampulha, Belo Horizonte-MG Brazil.
da Silva
Maria F S
MF
da Silva
Antônio C
AC
Carvalho
Claudia R
CR
Faria
Ana Maria C
AM
D000818:Animals; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D007108:Immune Tolerance; D007113:Immunity, Innate / Q000235:genetics*; D008297:Male; D051379:Mice; D010047:Ovalbumin / Q000276:immunology* / Q000494:pharmacology; D012641:Selection, Genetic
D010047:Ovalbumin