title: Staphylococcus aureus nasal carriage is not associated with known polymorphism in the Vitamin D receptor gene.
abstract: The vitamin D endocrine system has been shown to influence the immune response and polymorphisms in the vitamin D receptor (VDR) gene have been associated with susceptibility to infectious diseases. We determined if the Cdx2, FokI and BsmI-ApaI-TaqI polymorphisms in the VDR gene were associated with nasal carriage of Staphylococcal aureus. We defined the S. aureus nasal carriage status (persistent, intermittent or non-carriage) for a group of more that 2000 elderly volunteers. The prevalence of persistent S. aureus nasal carriage was 18%, which was, however, not associated with any of the variant VDR genotypes. Our study into genetic determinants of S. aureus carriage patterns is the largest in the field, but still we found no association between VDR gene variation and S. aureus nasal carriage.
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
authors.forename: Mark
authors.initials: M
authors.lastname: Claassen
authors.forename: Jan
authors.initials: J
authors.lastname: Nouwen
authors.forename: Yue
authors.initials: Y
authors.lastname: Fang
authors.forename: Alewijn
authors.initials: A
authors.lastname: Ott
authors.forename: Henri
authors.initials: H
authors.lastname: Verbrugh
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Alex
authors.initials: A
authors.lastname: van Belkum
authors.forename: André
authors.initials: A
authors.lastname: Uitterlinden
mesh_terms: D000368:Aged; D002353:Carrier State; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004262:DNA Restriction Enzymes / Q000378:metabolism; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009666:Nose / Q000382:microbiology*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification*
chemical_list: D018167:Receptors, Calcitriol; D004247:DNA; D004262:DNA Restriction Enzymes