Status of the progeny of rats treated with platinum-containing cytostatics.
Wistar rat pups from rats treated with first- and second-generation platinum-containing cytostatics (platidiam, carboplatin) 1, 3, and 6 months before mating with intact partners had similar disorders. The severity of these disorders depended in many cases on the chemical structure of the drug and sex of the parent treated with the cytostatic. The severity of toxic effects in the progeny of intact females mated with cytostatic-treated males decreased with prolongation of the period elapsing between the treatment and mating. Carboplatin produced a more potent toxic effect on the reproductive function of rats compared to platidiam.
Borovskaya
T G
TG
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Gol'dberg
V E
VE
Poluektova
M E
ME
Pakhomova
A V
AV
Timina
E A
EA
Gol'dberg
E D
ED
D000014:Abnormalities, Drug-Induced; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D016190:Carboplatin / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity*; D005260:Female; D008297:Male; D051381:Rats; D012098:Reproduction / Q000187:drug effects*
D000970:Antineoplastic Agents; D016190:Carboplatin; D002945:Cisplatin