title: Prenylbicyclogermacrane diterpenoids from the formosan soft coral Nephthea pacifica.
abstract: Ten new prenylbicyclogermacrane diterpenoids, pacificins A-J (1-10), were isolated from the methylene chloride solubles of the Formosan soft coral Nephthea pacifica. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
authors.affiliation: Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
authors.forename: Ali A H
authors.initials: AA
authors.lastname: El-Gamal
authors.forename: Shang-Kwei
authors.initials: SK
authors.lastname: Wang
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.forename: I-Gin
authors.initials: IG
authors.lastname: Chen
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013624:Taiwan
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes