Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice.
The inhibitory effects of 22 xanthones from three Guttiferae plants (Hypericum patulum, Calophyllum inophyllum and C. austroindium) on exogenous platelet activating factor (PAF)-induced hypotension were examined using a blood pressure monitoring in vivo assay method. Guanandin (2), caloxanthone E (3), 1,3,5,6-tetrahydroxy-2-isoprenylxanthone (8), 6-deoxyjacareubin (11) and patulone (18) showed strong inhibition of PAF-induced hypotension, with inhibitory effects of more than 60 %. Their ID50 values were greater than that of ginkgolide B (BN-52 021), a natural PAF-antagonist from the Ginkgo biloba.
Oku
Hisae
H
School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
Ueda
Yoshimi
Y
Iinuma
Munekazu
M
Ishiguro
Kyoko
K
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D029759:Calophyllum; D020902:Hypericum; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010972:Platelet Activating Factor
D000959:Antihypertensive Agents; D010936:Plant Extracts; D010972:Platelet Activating Factor