Clinical value of 99mTc-HMPAO SPECT in depressed bipolar I patients.
Regional cerebral blood flow was studied in 17 bipolar I depressed patients (DSM-IV criteria) with single photon emission computed tomography (SPECT). Visual analysis of images revealed no abnormality in eight patients and abnormal findings in nine patients. In the nine patients with abnormal findings, all showed regional decreases of the uptake of (99m)Tc-D,L-hexamethylpropylene amine oxime (HMPAO, four in the frontal region, two in the basal ganglia, and three in both the frontal region and the basal ganglia). The patients with visible SPECT abnormalities had significantly higher scores on the Hamilton Rating Scale for Depression (HDRS).
Benabarre
Antoni
A
Institut Clínic de Psiquiatria i Psicologia, Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, C/Villarroel 170, 08036 Barcelona, Spain. 31555abh@comb.es
Vieta
Eduard
E
Martín
Francisco
F
Lomeña
Francisco
F
Martínez-Aràn
Anabel
A
Colom
Francesc
F
Corbella
Barbara
B
Gastó
Cristóbal
C
Valdés
Manuel
M
D000328:Adult; D001479:Basal Ganglia / Q000098:blood supply; D001714:Bipolar Disorder / Q000175:diagnosis*; D001921:Brain / Q000098:blood supply*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime