Cellular oxidative processes in relation to renal disease.
This article summarizes the biochemical processes that produce reactive oxygen species (ROS) and other mediators that account for 'oxidative stress'. Formation of ROS in signal transduction cascades is illustrated from studies of kidney cell systems. The pathophysiological implications for the nephrologist are then reviewed.
Wardle
E Nigel
EN
nigel@edwinwardle.freeserve.co.uk
D000975:Antioxidants / Q000502:physiology; D005978:Glutathione / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000166:cytology; D007674:Kidney Diseases / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction
D000975:Antioxidants; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D005978:Glutathione