Comparative effects of Aegle marmelos extract and alpha-tocopherol on serum lipids, lipid peroxides and cardiac enzyme levels in rats with isoproterenol-induced myocardial infarction.
BACKGROUND
We demonstrate the effect of Aegle marmelos leaf extract (AMLEt) and alpha-tocopherol on plasma lipids, lipid peroxides and marker enzymes in rats with isoproterenol (ISO)-induced myocardial infarction.


METHODS
Rats were pre-treated orally for 35 days with different doses of an aqueous AMLEt (50 mg/ kg, 100 mg/kg and 200 mg/kg) prior to ISO-induced myocardial infarction. The effects on creatine kinase, lactate dehydrogenase, plasma thiobarbituric acid reactive substances, lipid hydroperoxides, serum lipids and lipoproteins were studied.


RESULTS
Pre-treatment with AMLEt at doses of 100 mg/kg and 200 mg/kg bodyweight for 35 days showed a significant effect on the activities of marker enzymes, lipid peroxides, lipids, lipoproteins and antioxidant enzymes in ISO-treated rats. The effect of AMLEt 200 mg/kg was found to be equal to the effect of alpha-tocopherol 60 mg/kg.


CONCLUSIONS
Aegle marmelos leaves possess antihyperlipidaemic effect in rats with ISO-induced myocardial infarction.
Rajadurai
M
M
Department of Biochemistry, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India.
Prince
P S M
PS
D000318:Adrenergic beta-Agonists; D045471:Aegle; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D005260:Female; D007545:Isoproterenol; D008054:Lipid Peroxides / Q000097:blood; D008055:Lipids / Q000097:blood; D009203:Myocardial Infarction / Q000097:blood* / Q000139:chemically induced / Q000201:enzymology; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D024502:alpha-Tocopherol / Q000627:therapeutic use*
D000318:Adrenergic beta-Agonists; D000975:Antioxidants; D015415:Biomarkers; D008054:Lipid Peroxides; D008055:Lipids; D024502:alpha-Tocopherol; D007545:Isoproterenol