title: Acetazolamide-enhanced neuroSPECT scan reveals functional impairment after minimal traumatic brain injury not otherwise discernible.
abstract: A patient suffering from aggressive personality changes and cognitive impairment following head trauma, without neurological or anatomical imaging findings, underwent neuroSPECT scans with and without acetazolamide injection, both before treatment and during treatment with valproate. Acetazolamide injection induced increased prefrontal perfusion not evident at baseline. Valproate treatment was associated with increased prefrontal perfusion concomitant with clinical improvement and abolished response to acetazolamide challenge.
authors.affiliation: Department of Psychiatry, Tel Aviv Sourasky Medical Center and Tel Aviv University Sackler Faculty of Medicine, 6 Weizmann St., Tel Aviv 64239, Israel.
authors.forename: Gavriel
authors.initials: G
authors.lastname: Barkai
authors.forename: Elinor
authors.initials: E
authors.lastname: Goshen
authors.forename: S
authors.initials: S
authors.lastname: Tzila Zwas
authors.forename: Ornah T
authors.initials: OT
authors.lastname: Dolberg
authors.forename: Chaim G
authors.initials: CG
authors.lastname: Pick
authors.forename: Omer
authors.initials: O
authors.lastname: Bonne
authors.forename: Shaul
authors.initials: S
authors.lastname: Schreiber
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D001921:Brain / Q000098:blood supply*; D001930:Brain Injuries / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010554:Personality Disorders / Q000175:diagnosis / Q000209:etiology; D012039:Regional Blood Flow / Q000187:drug effects; D015899:Tomography, Emission-Computed, Single-Photon; D014635:Valproic Acid / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D014635:Valproic Acid; D000086:Acetazolamide