title: Management and clinical outcomes of pregnant patients with invasive cervical cancer.
abstract: BACKGROUND
  The objective of this study was to evaluate the clinical outcomes and to discuss the management of women presenting with an invasive cervical cancer during pregnancy.
  
  
  METHODS
  We retrospectively reviewed patients treated for an invasive cervical cancer diagnosed during pregnancy between 1985 and 2000 in our institution.
  
  
  RESULTS
  Twenty-one pregnant patients among a total of 487 women were treated. Thirteen, five, two and one, respectively, were diagnosed during the first, second and third pregnancy trimester and post-partum. The FIGO stage was IB in 15 cases, IIB in five cases and IVA in one case. Mean follow-up was 64 months (range 2-165). Overall and disease-free survival at 5 years were 82% and 79%, respectively. All five patients diagnosed in the second trimester were alive. Two of the 13 patients and one of the two patients diagnosed during the first trimester and the third trimester, respectively, died of their disease. No difference was observed between the nine patients whose treatment was delayed or not.
  
  
  CONCLUSIONS
  Invasive cervical cancer during pregnancy is rare but is a dilemma for women and their physicians. The present study and review of the literature suggest that pregnancy does not seem to influence the prognosis of cervical cancer. Delayed treatment could be proposed to selected patients diagnosed at the end of the second trimester or at the beginning of the third trimester, with a small tumor (<2 cm) and negative nodes, after a multidisciplinary approach.
authors.affiliation: Department of radiothérapie, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94 805 Villejuif, France.
authors.forename: N
authors.initials: N
authors.lastname: Germann
authors.forename: C
authors.initials: C
authors.lastname: Haie-Meder
authors.forename: P
authors.initials: P
authors.lastname: Morice
authors.forename: C
authors.initials: C
authors.lastname: Lhomme
authors.forename: P
authors.initials: P
authors.lastname: Duvillard
authors.forename: K
authors.initials: K
authors.lastname: Hacene
authors.forename: A
authors.initials: A
authors.lastname: Gerbaulet
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D018579:Patient Selection; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000628:therapy*; D011256:Pregnancy Outcome; D011264:Pregnancy Trimesters; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000628:therapy*