title: Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study.
abstract: OBJECTIVE
  To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics.
  
  
  METHODS
  Population based retrospective cohort study.
  
  
  METHODS
  Ontario, Canada. Patients 32,710 older adults (< or = 65 years) with dementia (17,845 dispensed an atypical antipsychotic and 14,865 dispensed a typical antipsychotic).
  
  
  METHODS
  Admission to hospital with the most responsible diagnosis (single most important condition responsible for the patient's admission) of ischaemic stroke. Observation of patients until they were either admitted to hospital with ischaemic stroke, stopped taking antipsychotics, died, or the study ended.
  
  
  RESULTS
  After adjustment for potential confounders, participants receiving atypical antipsychotics showed no significant increase in risk of ischaemic stroke compared with those receiving typical antipsychotics (adjusted hazard ratio 1.01, 95% confidence interval 0.81 to 1.26). This finding was consistent in a series of subgroup analyses, including ones of individual atypical antipsychotic drugs (risperidone, olanzapine, and quetiapine) and selected subpopulations of the main cohorts.
  
  
  CONCLUSIONS
  Older adults with dementia who take atypical antipsychotics have a similar risk of ischaemic stroke to those taking typical antipsychotics.
authors.affiliation: Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, ON, Canada. gills@pccchealth.org
authors.forename: Sudeep S
authors.initials: SS
authors.lastname: Gill
authors.forename: Paula A
authors.initials: PA
authors.lastname: Rochon
authors.forename: Nathan
authors.initials: N
authors.lastname: Herrmann
authors.forename: Philip E
authors.initials: PE
authors.lastname: Lee
authors.forename: Kathy
authors.initials: K
authors.lastname: Sykora
authors.forename: Nadia
authors.initials: N
authors.lastname: Gunraj
authors.forename: Sharon-Lise T
authors.initials: SL
authors.lastname: Normand
authors.forename: Jerry H
authors.initials: JH
authors.lastname: Gurwitz
authors.forename: Connie
authors.initials: C
authors.lastname: Marras
authors.forename: Walter P
authors.initials: WP
authors.lastname: Wodchis
authors.forename: Muhammad
authors.initials: M
authors.lastname: Mamdani
mesh_terms: D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D015331:Cohort Studies; D003704:Dementia / Q000188:drug therapy* / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D009864:Ontario / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000139:chemically induced*
chemical_list: D014150:Antipsychotic Agents