title: Ropivacaine 0.1% with fentanyl 2 microg mL(-1) by epidural infusion for labour analgesia.
abstract: OBJECTIVE
  To evaluate the efficacy of 0.1% ropivacaine with fentanyl 2 microg mL(-1) via epidural for analgesia in labour.
  
  
  METHODS
  In a randomized study, 80 nulliparous parturients in labour had epidural analgesia initiated with 0.2% ropivacaine and fentanyl and were then randomized to receive either 0.1% ropivacaine with fentanyl 2 microg mL(-1) at 10mL h(-1) (Group R1, n = 38) or 0.2% ropivacaine with fentanyl 2 microg mL(-1) at 8 ml h(-1) (Group R2, n = 39) as epidural infusions. Supplementary analgesia was provided on request with ropivacaine 0.2% 5 mL as an epidural bolus.
  
  
  RESULTS
  There were no significant differences between the visual analogue pain scores either with respect to motor block or sensory block. The amount of local anaesthetic used was lower in the 0.1% ropivacaine group than in the 0.2% ropivacaine group (P = 0.001). Side-effects, patient satisfaction, labour outcome and neonatal outcomes were similar in both groups.
  
  
  CONCLUSIONS
  An epidural infusion of 0.1% ropivacaine with fentanyl 2 microg mL(-1) at 10 mL h(-1) provided adequate analgesia in the first stage of labour. The level of analgesia was similar to that obtained using 0.2% ropivacaine with fentanyl 2 microg mL(-1) and with no differences with regard to motor or sensory block.
authors.affiliation: Institut Universitari Dexeus, Department of Anaesthesiology, Barcelona, Spain. mamenat@terra.es
authors.forename: M C
authors.initials: MC
authors.lastname: Atienzar
authors.forename: J M
authors.initials: JM
authors.lastname: Palanca
authors.forename: R
authors.initials: R
authors.lastname: Borras
authors.forename: I
authors.initials: I
authors.lastname: Esteve
authors.forename: M
authors.initials: M
authors.lastname: Fernandez
authors.forename: A
authors.initials: A
authors.lastname: Miranda
mesh_terms: D000328:Adult; D000577:Amides / Q000008:administration & dosage*; D015360:Analgesia, Epidural; D016362:Analgesia, Obstetrical; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D010147:Pain Measurement; D011247:Pregnancy; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000701:Analgesics, Opioid; D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D000077212:Ropivacaine; D005283:Fentanyl