Update on beta-lactam allergy diagnosis.
Allergic reactions to penicillin and cephalosporin antibiotics are common. The mechanisms involved are heterogeneous and not yet completely understood. However, clinical and immunologic studies suggest that type I (IgE-mediated) and type IV (cell-mediated) pathogenic mechanisms are involved in most immediate and non-immediate reactions, respectively. The diagnostic procedure has recently been standardized under the aegis of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interest group on drug hypersensitivity. In this review, we describe the general guidelines for evaluating subjects in whom there is suspicion of allergic reactions to beta-lactams.
Demoly
Pascal
P
Exploration des Allergies, Maladies Respiratoires, INSERM U454-IFR3, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, 34295 Montpellier Cedex 5, France. demoly@montp.inserm.fr
Romano
Antonino
A
D000900:Anti-Bacterial Agents / Q000276:immunology* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis*; D015994:Incidence; D008297:Male; D017410:Practice Guidelines as Topic; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012882:Skin Tests; D047090:beta-Lactams / Q000276:immunology* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D047090:beta-Lactams