title: [The influence of FcgammaRIIa polymorphism on rheumatoid arthritis].
abstract: The FcgammaRIIa receptor is most widely distributed of the Fcgamma receptors and is expressed on the most types of immunocomponent cells. Polymorphism of the FcgammaRIIa receptors may modulate immune complex mediated inflammation, particularly when immune complex contains IgG. The aim of the study was to evaluate the influence the FcgammaRIIa polymorphism on disease parameters activity in patients with rheumatoid arthritis (RA). The study included 75 patients with RA diagnosed according to the American College of Rheumatology criteria. In each patient the following parameters of disease activity were evaluated during one-year period: number of swollen and tender joints, morning stiffness duration, CRP, ESR as well as the disease activity in global physical assessment. There was no correlation between disease activity parameters and FcgammaRIIa polymorphism. Our results suggest, that FcgammaRIIa polymorphism does not represent an important genetic risk factor for RA activity.
authors.affiliation: Zakład Farmakokinetyki i Terapii, Monitorowanej Pomorskiej AM w Szczecinie.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pawlik
authors.forename: Lidia
authors.initials: L
authors.lastname: Ostanek
authors.forename: Iwona
authors.initials: I
authors.lastname: Brzosko
authors.forename: Ewa
authors.initials: E
authors.lastname: Dabrowska-Zamojcin
authors.forename: Marek
authors.initials: M
authors.lastname: Brzosko
authors.forename: Marcin
authors.initials: M
authors.lastname: Florczak
authors.forename: Barbara
authors.initials: B
authors.lastname: Gawrońska-Szklarz
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005838:Genotype; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*
chemical_list: C445323:FCGR2A protein, human; D007074:Immunoglobulin G; D017452:Receptors, IgG; D002097:C-Reactive Protein