title: Intrauterine instillation of trichloroacetic acid is effective for the treatment of dysfunctional uterine bleeding.
abstract: OBJECTIVE
  To evaluate the effectiveness of trichloroacetic acid (TCA) instillation into uterine cavity for the treatment of dysfunctional uterine bleeding (DUB).
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  A university research hospital.
  
  
  METHODS
  Ninety women participated who had dysfunctional uterine bleeding.
  
  
  METHODS
  Ninety-five percent of TCA was instilled into uterine cavity for endometrial ablation in women with dysfunctional uterine bleeding who want conservative treatment. Participants in group 1 received only TCA; participants in group 2 received a single dose of gonadotropin-releasing hormone analogue 1 month before the procedure.
  
  
  METHODS
  All participants underwent an evaluation that included cycle history, body mass index measurement, and transvaginal ultrasonography of pelvis, diagnostic hysteroscopy and endometrial biopsy.
  
  
  RESULTS
  At the end of 12 months of the treatment, amenorrhea rates in group 1 and group 2 were 26.7% vs. 31.1%, with pooled amenorrhea, hypomenorrhea, and eumenorrhea rates of 95.6% vs. 97.8%, respectively. There was no significant difference between the groups vis-a-vis postprocedure results. More than 90% of women who have this procedure are satisfied with the results. There were no observed negative effects or related complications with this treatment.
  
  
  CONCLUSIONS
  An instillation of TCA into uterine cavity produces acceptable results and provides conservative management of DUB.
authors.affiliation: Department of Obstetrics and Gynecology, Trakya University Research Hospital, Edirne, Turkey. drmustafakucuk@yahoo.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kucuk
authors.forename: Tulay Kilic
authors.initials: TK
authors.lastname: Okman
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use; D008875:Middle Aged; D011446:Prospective Studies; D014238:Trichloroacetic Acid / Q000008:administration & dosage*; D014592:Uterine Hemorrhage / Q000188:drug therapy*
chemical_list: D014238:Trichloroacetic Acid; D016729:Leuprolide