title: Resistance of native and circulating modified low-density lipoproteins in human blood to association.
abstract: The resistance of native and circulating modified low-density lipoproteins from human blood to spontaneous and polyethylene glycol-induced association was studied by recording light transmission fluctuations. Circulating modified low-density lipoproteins were less resistant to association than native low-density lipoproteins. Polyethylene glycol-induced association of low-density lipoproteins was irreversible. Our results suggest that atherogenic activity of circulating modified low-density lipoproteins is associated with their increased predisposition to irreversible association.
authors.affiliation: Laboratory for Mechanisms of Atherogenesis, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Russian Ministry of Health. inat@cardio.ru
authors.forename: I V
authors.initials: IV
authors.lastname: Suprun
authors.forename: A A
authors.initials: AA
authors.lastname: Mel'nichenko
authors.forename: I A
authors.initials: IA
authors.lastname: Sobenin
authors.forename: O M
authors.initials: OM
authors.lastname: Panasenko
authors.forename: A N
authors.initials: AN
authors.lastname: Orekhov
mesh_terms: D001161:Arteriosclerosis / Q000097:blood; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D066298:In Vitro Techniques; D008027:Light; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry* / Q000187:drug effects; D011092:Polyethylene Glycols / Q000494:pharmacology
chemical_list: D008077:Lipoproteins, LDL; D011092:Polyethylene Glycols