Thromboembolic disease detection at indirect CT venography versus CT pulmonary angiography.
OBJECTIVE
To assess the incremental increase in thromboembolic disease detection at indirect computed tomographic (CT) venography versus CT pulmonary angiography and to determine the importance of scan interval for indirect CT venography on the basis of thrombus length.


METHODS
Institutional review board approval was obtained, and informed consent was not required. The study included 1590 consecutive patients undergoing CT pulmonary angiography for the suspicion of pulmonary embolism. Two minutes after completion of pulmonary angiography, a contiguous indirect CT venography was performed from the iliac crest to the popliteal fossa. The presence of pulmonary embolism or deep venous thrombosis (DVT) was recorded for all patients. The lengths of all deep venous thrombi found in the first 378 consecutive patients were recorded.


RESULTS
Pulmonary embolism was detected in 243 (15%) of 1590 patients at CT pulmonary angiography, and DVT was detected in 148 (9%) patients at indirect CT venography. Among 148 patients with DVT, pulmonary embolism was detected in 100 patients at CT pulmonary angiography. Thus, the addition of indirect CT venography to CT pulmonary angiography resulted in a 20% incremental increase in thromboembolic disease detection compared with that at CT pulmonary angiography alone (99% confidence interval: 17%, 23%). Among the 378 patients, DVT was present in 33 patients at indirect CT venography. Two (6%) of 33 patients had clots measuring 2 cm or less, six (18%) had clots measuring 3-4 cm, and 25 (76%) had clots measuring more than 4 cm in length.


CONCLUSIONS
The addition of indirect CT venography to CT pulmonary angiography incrementally increases the detection rate of thromboembolic disease by 20%. Performance of indirect CT venography by using contiguous section intervals, with a section width of 1 cm, is recommended to accurately detect DVT.
Cham
Matthew D
MD
Department of Radiology, Strong Memorial Hospital-University of Rochester School of Medicine and Dentistry, 620 Park Ave, PMB 244, Rochester, NY 14607, USA. matthew_cham@urmc.rochester.edu
Yankelevitz
David F
DF
Henschke
Claudia I
CI
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010690:Phlebography / Q000379:methods*; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging; D013923:Thromboembolism / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D020246:Venous Thrombosis / Q000000981:diagnostic imaging