title: Effect of in vivo hypoxic preconditioning on changes in intracellular calcium content induced by long-term anoxia in rat brain slices.
abstract: We studied changes in intracellular calcium content induced by 10-min anoxia in olfactory cortex slices from rats exposed to single or 3-fold moderate hypobaric hypoxia ("ascend" at 5000 m). Repeated preconditioning with moderate hypobaric hypoxia produced a neuroprotective effect. This treatment abolished pathological calcium overload in brain slices induced in vitro by 10-min test anoxia.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
authors.forename: D G
authors.initials: DG
authors.lastname: Semenov
authors.forename: O L
authors.initials: OL
authors.lastname: Miller
authors.forename: M O
authors.initials: MO
authors.lastname: Samoilov
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000378:metabolism* / Q000517:prevention & control; D066298:In Vitro Techniques; D007424:Intracellular Fluid / Q000378:metabolism; D019194:Ischemic Preconditioning / Q000379:methods; D008297:Male; D009833:Olfactory Pathways / Q000378:metabolism; D051381:Rats; D011921:Rats, Inbred WKY; D013997:Time Factors
chemical_list: D002118:Calcium