title: Sol-gel derived potentiometric pH sensors.
abstract: A potentiometric sol-gel derived (xerogel) pH sensor based on covalently attached amine groups is described. The sensor consists of a Ag/AgCl electrode coated with a hybrid aminosilane/alkylsilane xerogel film. Various combinations of aminosilanes and alkylsilanes are evaluated for their potentiometric response to pH. The optimal sensor design is composed of (aminoethylaminomethyl)phenethyltrimethoxysilane and methyltrimethoxysilane. This sensor exhibits near-Nerstian response (-55 mV.decade(-)(1)), responds rapidly (< or =3 s) to changes in pH, and has H(+) selectivity coefficients (log K(pot)(H)()+ (, )(j)()) of -13 and -11 for interfering j cations Na(+) and K(+), respectively. In vitro platelet adhesion tests indicate that the xerogel coatings are more blood compatible than conventional poly(vinyl chloride) and poly(urethane) ion-selective electrode coatings.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA.
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Marxer
authors.forename: Mark H
authors.initials: MH
authors.lastname: Schoenfisch
mesh_terms: D000588:Amines / Q000737:chemistry; D000818:Animals; D015374:Biosensing Techniques; D001792:Blood Platelets / Q000378:metabolism; D002412:Cations; D005782:Gels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D017736:Ion-Selective Electrodes; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011140:Polyurethanes / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry; D011188:Potassium / Q000737:chemistry; D011199:Potentiometry / Q000295:instrumentation / Q000379:methods*; D012821:Silanes / Q000737:chemistry; D012964:Sodium / Q000737:chemistry; D013552:Swine
chemical_list: D000588:Amines; D002412:Cations; D005782:Gels; D011140:Polyurethanes; D012821:Silanes; C071718:methyltrimethoxysilane; D011143:Polyvinyl Chloride; D012964:Sodium; D011188:Potassium