title: Effector CD8+T cells are suppressed by measles virus infection during delayed type hypersensitivity reaction.
abstract: Measles virus infection reduces or abolishes delayed type hypersensitivity reactions (DTH) in humans. We have previously shown that the primary 2,4-dinitrofluorobenzene (DNFB) response is temporarily suppressed by measles virus in cotton rats. Here, we demonstrate that also the secondary DNFB response (cutaneous hypersensitivity [CHS]) is suppressed in cotton rats by measles virus infection. As in mice, DNFB specific CD8 T cells are the predominant T cell response in cotton rats. After MV infection, CD8 T cells are reduced in their proliferative capacity whereas the CD4/CD8 ratio, the number and activation status of CD8 T cells is not affected. As a result of impaired proliferation of DNFB specific T cells the DTH response (measured as ear swelling) is reduced in measles virus infected cotton rats. At the same time as DNFB specific T cell responses are suppressed, spontaneous proliferation of lymphocytes as evidence for immune activation is found.
authors.affiliation: Institut fuer Virologie und Immunbiologie, Wuerzburg, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Streif
authors.forename: Karin
authors.initials: K
authors.lastname: Pueschel
authors.forename: Annette
authors.initials: A
authors.lastname: Tietz
authors.forename: Jorge
authors.initials: J
authors.lastname: Blanco
authors.forename: Volker Ter
authors.initials: VT
authors.lastname: Meulen
authors.forename: Stefan
authors.initials: S
authors.lastname: Niewiesk
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004139:Dinitrofluorobenzene / Q000008:administration & dosage / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology*; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008297:Male; D008457:Measles / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D016205:Sigmodontinae
chemical_list: D004139:Dinitrofluorobenzene