title: Photoinduced switch of a DNA/RNA inactive molecule into a classical intercalator.
abstract: Spectroscopic titrations and thermal denaturation experiments show that "acyclic" analogue 1 does not bind to ds-DNA, but under same conditions "cyclic" 2 strongly interacts with ds-DNA and ds-RNA by intercalation into the double helix. Besides, 2 is significantly more effective in inhibition of the tumor cell growth in vitro than 1. We have shown that it is possible to efficiently and irreversibly convert "DNA inactive" compound 1 into "DNA active" compound 2 by light irradiation of the aqueous solutions of the former. This strategy offers a new and attractive approach to photoinduced anticancer therapy.
authors.affiliation: Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, HR-10000 Zagreb, Croatia.
authors.forename: Kristina
authors.initials: K
authors.lastname: Starcević
authors.forename: Grace
authors.initials: G
authors.lastname: Karminski-Zamola
authors.forename: Ivo
authors.initials: I
authors.lastname: Piantanida
authors.forename: Mladen
authors.initials: M
authors.lastname: Zinić
authors.forename: Lidija
authors.initials: L
authors.lastname: Suman
authors.forename: Marijeta
authors.initials: M
authors.lastname: Kralj
mesh_terms: D003500:Cyclization; D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D007700:Kinetics; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D010777:Photochemistry; D012313:RNA / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D007364:Intercalating Agents; D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D012313:RNA; D004247:DNA