A new approach to construct full-length glycosylphosphatidylinositols of parasitic protozoa and [4-deoxy-Man-III]-GPI analogues.
A new [2 + 2 + 2] approach to construct GPI molecules through the efficient synthesis of glucosamine-inositol and tetramannose intermediates led to a total synthesis of a GPI-anchor of Trypanosoma cruzi, and also afforded a key intermediate for the synthesis of valuable [4-deoxy-Man-III]-GPI analogues.
Ali
Asif
A
Bio-organic Chemistry Laboratory, National Institute of Immunology, JNU Complex, New Delhi, India.
Gowda
D Channe
DC
Vishwakarma
Ram A
RA
D000818:Animals; D005944:Glucosamine / Q000138:chemical synthesis; D017261:Glycosylphosphatidylinositols / Q000138:chemical synthesis* / Q000737:chemistry; D007294:Inositol / Q000138:chemical synthesis; D008358:Mannose / Q000138:chemical synthesis; D015394:Molecular Structure; D014349:Trypanosoma cruzi / Q000737:chemistry*
D017261:Glycosylphosphatidylinositols; D007294:Inositol; D005944:Glucosamine; D008358:Mannose