title: Polygynax in the treatment of fungal and non specific vaginitis.
abstract: BACKGROUND
  Polygynax is a product commercialized in the form of vaginal capsule, associating bactericidal antibiotics: Neomycin, Polymyxin B and Nystatin--an antifungal agent which is fungicidal and fungistatic in vitro and in vivo.
  
  
  OBJECTIVE
  The objectives of the study were to analyze the clinical and bacteriological efficacy of Polygynax in the treatment of bacterial vaginitis with one or more germs (mixed vaginitis) and Candida infections, and to investigate the correlation between the results of the initial clinical examination and bacteriological studies.
  
  
  METHODS
  The study covered 88 patients diagnosed with mixed vaginitis during initial screening of vaginal flora (direct Gram stains and standard microbiology laboratory methods for cultivation of vagina/ cervix smears with antibiotic susceptibility testing). The patients were treated with Polygynax, applied in form of vaginal capsules (during 12 days, application before retiring). After at least 30 days following last day of therapy, the same diagnostic swabs were repeated. In this period, averaging 38.4 days, sexual abstinence was recommended.
  
  
  RESULTS
  The results showed that total clearance of present germs was found in 83/88 patients (94.3% of the cases), according to the repeated cervico- vaginal smears.
  
  
  CONCLUSIONS
  Polygynax is a treatment of preference against fungal infections, with added advantage of having wide antibacterial spectrum.
authors.affiliation: Department of Gynecology and Obstetrics, Clinical Centre, Skopje.
authors.forename: Dimitrov
authors.initials: D
authors.lastname: Goran
authors.forename: Antovska
authors.initials: A
authors.lastname: Vesna
authors.forename: Stefanija
authors.initials: S
authors.lastname: Adela
authors.forename: Trajkovska-Kiurcik
authors.initials: TK
authors.lastname: Biljana
authors.forename: Milenkova
authors.initials: M
authors.lastname: Snezana
mesh_terms: D001152:Arsenicals / Q000008:administration & dosage / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology; D004338:Drug Combinations; D005260:Female; D006801:Humans; D009355:Neomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D009761:Nystatin / Q000008:administration & dosage / Q000627:therapeutic use*; D011113:Polymyxins / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014626:Vaginal Smears; D016585:Vaginosis, Bacterial / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D001152:Arsenicals; D004338:Drug Combinations; D011113:Polymyxins; D009761:Nystatin; C006119:acetarsol, dimethicone, neomycin, nystatin, polymyxin drug combination; D009355:Neomycin