gem-Difluorination of 2,2-diaryl-1,3-dithiolanes by Selectfluor and pyridinium polyhydrogen fluoride.
2,2-diaryl-1,3-dithiolanes, readily obtainable from diaryl ketones, were transformed into the corresponding gem-difluoro compounds using a novel reagent combination involving Selectfluor and pyridinium polyhydrogen fluoride (PPHF) under mild conditions in moderate to good yields.
Reddy
V Prakash
VP
Department of Chemistry, University of Missouri-Rolla, Rolla, MO 65409-00010, USA. preddy@umr.edu
Alleti
Ramesh
R
Perambuduru
Meher K
MK
Welz-Biermann
Urs
U
Buchholz
Herwig
H
Prakash
G K Surya
GK
D003979:Diazonium Compounds / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011726:Pyridinium Compounds / Q000737:chemistry*
D003979:Diazonium Compounds; D006571:Heterocyclic Compounds; D011726:Pyridinium Compounds; D005461:Fluorine; C012948:1,3-dithiolane; C408750:selectfluor