title: Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetes.
abstract: Insulin peptide B:9-23 (amino acids 9 to 23 of the B chain) can induce immune targeting of insulin and islets in normal Balb/c mice. The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
authors.forename: Devasenan
authors.initials: D
authors.lastname: Devendra
authors.forename: Johanna
authors.initials: J
authors.lastname: Paronen
authors.forename: Edwin
authors.initials: E
authors.lastname: Liu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Moriyama
authors.forename: Robert
authors.initials: R
authors.lastname: Taylor
authors.forename: Dongmei
authors.initials: D
authors.lastname: Miao
authors.forename: Liping
authors.initials: L
authors.lastname: Yu
authors.forename: George
authors.initials: G
authors.lastname: Eisenbarth
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015703:Antigens, CD; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D004195:Disease Models, Animal; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use*; D007330:Insulin Antibodies / Q000097:blood*; D039001:Integrin alpha Chains; D051379:Mice; D008807:Mice, Inbred BALB C; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000627:therapeutic use*
chemical_list: D015703:Antigens, CD; D007328:Insulin; D007330:Insulin Antibodies; D039001:Integrin alpha Chains; D010446:Peptide Fragments; C091367:alpha E integrins; C041903:insulin B (9-30)