Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigs.
Osmotic diuretics are therapeutic agents used to reduce endolymphatic hydrops. However, glycerol-induced change in endolymph volume is followed by a rebound phenomenon. In this study, we investigated the rebound phenomenon occurring with isosorbide, an osmotic diuretic used as a therapeutic agent for Ménière's disease in Japan. Forty guinea pigs underwent surgical obliteration of the endolymphatic sac. Thirty received isosorbide orally 1 month after surgery. These animals were sacrificed 3, 6, or 12 h after isosorbide intake. The remaining 10 animals served as controls. Quantitative assessment of changes in the endolymphatic space was performed light-microscopically. Isosorbide reduced cochlear endolymph volume, with a peak reduction 6 h after intake. Thereafter, no prominent rebound phenomenon was noted. Clinically, since isosorbide is orally administered every 8 h, rebound phenomenon need not be considered in the treatment with isosorbide.
Kakigi
Akinobu
A
Department of Otolaryngology, Kochi Medical School, Nankoku, Japan. kakigia@kochi-ms.ac.jp
Takeda
Setsuko
S
Takeda
Taizo
T
Sawada
Shoichi
S
Azuma
Hiroshi
H
Higashiyama
Kasumi
K
Yamakawa
Kazuhiro
K
Takeuchi
Shunji
S
D000284:Administration, Oral; D000818:Animals; D003053:Cochlear Duct / Q000187:drug effects; D004195:Disease Models, Animal; D004234:Diuretics, Osmotic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004710:Endolymph / Q000187:drug effects* / Q000378:metabolism; D018159:Endolymphatic Hydrops / Q000139:chemically induced / Q000188:drug therapy*; D005990:Glycerol / Q000737:chemistry / Q000494:pharmacology; D006168:Guinea Pigs; D007547:Isosorbide / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
D004234:Diuretics, Osmotic; D005990:Glycerol; D007547:Isosorbide