title: Herbicide resistance in transgenic plants with mammalian P450 monooxygenase genes.
abstract: Transgenic potato and rice plants were generated by the introduction of human P450 species, CYP1A1, CYP2B6, CYP2C9 and CYP2C19, which metabolized a number of herbicides, insecticides and industrial chemicals. The transgenic potato plant T1977 co-expressing CYP1A1, CYP2B6 and CYP2C19 genes showed remarkable cross-resistance to several herbicides with different structures and modes of action due to metabolism of these herbicides by the P450 species expressed. The transgenic rice plant 2C9-57R2 expressing CYP2C9 gene showed resistance to sulfonylureas, and the transgenic rice plant 2C19-12R1 expressing CYP2C19 gene showed cross-resistance to certain herbicides with different structures and modes of action. These transgenic plants appear to be useful for herbicide resistance as well as phytoremediation of environmental contaminants.
authors.affiliation: Research Center for Environmental Genomics, Kobe University, Kobe, 657-8501, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Inui
authors.forename: Hideo
authors.initials: H
authors.lastname: Ohkawa
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism*; D004351:Drug Resistance / Q000235:genetics; D006540:Herbicides / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007306:Insecticides / Q000378:metabolism; D008322:Mammals; D030821:Plants, Genetically Modified / Q000187:drug effects* / Q000201:enzymology
chemical_list: D006540:Herbicides; D007306:Insecticides; D003577:Cytochrome P-450 Enzyme System