A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.
The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.
Essex-Lopresti
Angela E
AE
Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom. aeelopresti@dstl.gov.uk
Boddey
Justin A
JA
Thomas
Richard
R
Smith
Martin P
MP
Hartley
M Gill
MG
Atkins
Timothy
T
Brown
Nat F
NF
Tsang
Chuk Hai
CH
Peak
Ian R A
IR
Hill
Jim
J
Beacham
Ifor R
IR
Titball
Richard W
RW
D000818:Animals; D001422:Bacterial Adhesion / Q000235:genetics / Q000502:physiology*; D016957:Burkholderia pseudomallei / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D017173:Caenorhabditis elegans / Q000378:metabolism / Q000382:microbiology; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000378:metabolism / Q000382:microbiology; D036781:Fimbriae Proteins / Q000378:metabolism*; D010861:Fimbriae, Bacterial / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D013997:Time Factors
D036781:Fimbriae Proteins