title: Evaluation of a new cardiac recovery system in a bovine model of volume overload heart failure.
abstract: We evaluated the short-term hemodynamic efficacy of the Cancion cardiac recovery system (CRS) in a bovine model of volume overload heart failure. We created severe mitral regurgitation (MR) by disrupting the mitral chordae tendineae of two calves, which were allowed to survive for 13 and 11 months. Four hours before we killed the calves, we introduced the CRS, which maintained flows of 1.2 L/min. Hemodynamic data were recorded before and after MR creation and CRS initiation. Left ventriculography was performed at those same intervals and 4 hours after CRS initiation. After chordal disruption, the left ventricular end-diastolic pressure (LVEDP) increased from 14 to 23 mm Hg in calf 1 and 15 to 27 mm Hg in calf 2. After 4 hours of CRS support, the LVEDP decreased from 23 to 8 mm Hg (calf 1) and 27 to 14 mm Hg (calf 2); dP/dt increased from 1,373 to 2,900 mm Hg/s (calf 1) and 1,068 to 2,384 mm Hg/s (calf 2). MR decreased from 3+ to 1 in calf 2 but could not be determined in calf 1. In this bovine model of volume overload heart failure, the CRS unloaded the left ventricle and reduced the afterload. Future trials will determine the pump's ability to treat congestive heart failure.
authors.affiliation: Cardiovascular Surgical Research Laboratory, Texas Heart Institute, 1101 Bates Avenue, MC 1-268, Houston, TX 77030, USA.
authors.forename: Egemen
authors.initials: E
authors.lastname: Tuzun
authors.forename: Jeff
authors.initials: J
authors.lastname: Conger
authors.forename: Igor D
authors.initials: ID
authors.lastname: Gregoric
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Eya
authors.forename: Fred J
authors.initials: FJ
authors.lastname: Clubb
authors.forename: Scott D
authors.initials: SD
authors.lastname: Flamm
authors.forename: O H
authors.initials: OH
authors.lastname: Frazier
authors.forename: Branislav
authors.initials: B
authors.lastname: Radovancevic
mesh_terms: D000818:Animals; D002303:Cardiac Output, Low / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D002417:Cattle; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006353:Heart-Assist Devices; D006940:Hyperemia / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure; D011474:Prosthesis Design; D011859:Radiography; D020127:Recovery of Function; D013318:Stroke Volume