Effect of antithrombin III on local hemostasis in the kidneys during experimental nephritis.
Administration of antithrombin III-enriched plasma to rabbits with acute Masugi nephritis inhibited prothrombinase formation and increased the release of component C3 from the kidneys. This treatment had a cytoprotective effect and was probably followed by dissociation of antigen--antibody complexes.
Sokratov
N V
NV
Research-and-Training Center for Problems of Human Vital Activity, Russian Academy of Sciences, Orenburg.
D000818:Animals; D000990:Antithrombin III / Q000494:pharmacology* / Q000627:therapeutic use; D003176:Complement C3 / Q000096:biosynthesis; D004195:Disease Models, Animal; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects*; D009393:Nephritis / Q000097:blood* / Q000188:drug therapy; D011498:Protein Precursors / Q000096:biosynthesis; D011817:Rabbits; D013925:Thromboplastin / Q000096:biosynthesis
D003176:Complement C3; D011498:Protein Precursors; D000990:Antithrombin III; D006493:Heparin; D013925:Thromboplastin