Synthesis and antifungal activity of noble 5-arylamino- and 6-arylthio-4,7-dioxobenzoselenazoles.
5-Arylamino- and 6-arylthio-4,7-dioxobenzoselenazoles 4 and 5 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 5-Arylamino-4,7-dioxobenzoselenazoles 4 showed, in general, more potent antifungal activity than 6-arylthio-4,7-dioxobenzoselenazoles 5. The results suggest that 5-arylamino-4,7-dioxobenzoselenazoles 4 would be potent antifungal agents.
Ryu
Chung-Kyu
CK
College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@mm.ewha.ac.kr
Han
Ja-Young
JY
Jung
Ok-Jai
OJ
Lee
Su-Kyung
SK
Lee
Jung Yoon
JY
Jeong
Seong Hee
SH
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D016566:Organoselenium Compounds