title: [Ethylene glycol poisoning complicated by central nervous system abnormalities].
abstract: We report a case of ethylene glycol (EG) poisoning complicated by central nervous system abnormalities. A long-distance truck driver aged 36 year old ingested 200ml of EG in a suicidal attempt. He was referred to our hospital from another hospital because of vomiting and altered mental status. On arrival at our hospital, he had low level of consciousness (Glasgow Coma Scale: E3V4M5), miosis, and external ophthalmoplegia. Laboratory analysis revealed a severe metabolic acidosis with wide anion gap. Many crystals were detected in the urinary sediment. After admission, acute oliguric renal failure required continuous hemodialysis for 6 days. Despite the treatment, the level of consciousness did not improve. The CT scan of the brain obtained on the fourth day revealed low density areas in the bilateral basal ganglia, mid brain and pons. The renal biopsy showed tubular oxalate deposits. After 12 days, the volume of urination increased. At the same time the mental status gradually recovered. He was discharged on 36 days after admission without any sequelae.
authors.affiliation: Department of Emergency of Medicine, Kawasaki Medical University.
authors.forename: Keiko
authors.initials: K
authors.lastname: Ohmori
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kumada
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kimura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishihara
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Fukuda
authors.forename: Kouichirou
authors.initials: K
authors.lastname: Suzuki
authors.forename: Akitsugu
authors.initials: A
authors.lastname: Kohama
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D003244:Consciousness Disorders / Q000139:chemically induced* / Q000628:therapy; D005026:Ethylene Glycols / Q000506:poisoning*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020258:Neurotoxicity Syndromes / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006435:Renal Dialysis; D013406:Suicide, Attempted; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005026:Ethylene Glycols