title: [Left ventricular functional parameters: comparison of 16-slice spiral CT with MRI].
abstract: OBJECTIVE
  The quantitative measurement of left ventricular functional parameters using multislice computed tomography (MSCT) with retrospective ECG-gating and comparison of the results with magnetic resonance imaging (MRI).
  
  
  METHODS
  Thirty-one patients with suspected or known coronary artery disease underwent MSCT angiography with retrospective ECG-gating (Sensation 16, Siemens). Based on the CT data set, short axis reformations of the left ventricle were performed for functional analysis. On a commercially available workstation, end-diastolic- (EDV), end-systolic- (ESV), stroke volume (SV), ejection fraction (EF) and myocardial mass (MM) were calculated from MSCT (temporal resolution 105 - 210 ms) data according to the modified Simpson's rule and compared to MRI (1.5 T scanner, temporal resolution 48 ms) using a 2D TrueFISP cine sequence with respiration hold.
  
  
  RESULTS
  In all cases, the quality was adequate for both MSCT and MRI. MSCT and MRI had an excellent correlation for EDV (r = 0.86), ESV (r = 0.91), EF (r = 0.87) and MM (r = 0.88), and a good correlation for SV (r = 0.70). The mean difference was 13.2 +/- 21.9 ml for EDV, 8.7 +/- 15.9 ml for ESV, 4.6 +/- 12.3 ml for SV, 1.4 +/- 5.2 % for EF, and 11.9 +/- 13.8 g for MM. However, EDV (p = 0.002), ESV (p = 0.005), SV (p = 0.048), and MM (p < 0.0001) were significantly overestimated with MSCT compared to MRI. For EF, no significant difference between MSCT and MRI was found (p = 0.15).
  
  
  CONCLUSIONS
  For left ventricular functional parameters, MSCT of the heart with retrospective ECG-gating showed a high correlation with MRI, which has an important implication when using MSCT for non-invasive cardiac imaging. Despite the high correlation, overestimation of EDV, EVS, SV, and MM with MSCT has to be taken into account when applying this technology in clinical practice. EF was not significantly different between both modalities.
authors.affiliation: Abteilung für Radiologische Diagnostik, Universitätsklinik Tübingen.
authors.forename: M
authors.initials: M
authors.lastname: Heuschmid
authors.forename: J
authors.initials: J
authors.lastname: Rothfuss
authors.forename: S
authors.initials: S
authors.lastname: Schröder
authors.forename: A
authors.initials: A
authors.lastname: Küttner
authors.forename: M
authors.initials: M
authors.lastname: Fenchel
authors.forename: N
authors.initials: N
authors.lastname: Stauder
authors.forename: A H
authors.initials: AH
authors.lastname: Mahnken
authors.forename: C
authors.initials: C
authors.lastname: Burgstahler
authors.forename: S
authors.initials: S
authors.lastname: Miller
authors.forename: C D
authors.initials: CD
authors.lastname: Claussen
authors.forename: A F
authors.initials: AF
authors.lastname: Kopp
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003627:Data Interpretation, Statistical; D003971:Diastole; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D013599:Systole; D036542:Tomography, Spiral Computed; D016277:Ventricular Function, Left