Chronic administration of imipramine decreases freezing time in rats genetically predisposed to catalepsy.
The effects of acute and chronic imipramine treatment on the degree of catalepsy were compared in GC rats genetically predisposed to catalepsy. We recorded the time over which the rats remained in a vertical position they were placed. As differentiated from acute treatment, chronic administration of imipramine dose-dependently decreased the time of freezing in GC rats.
Kulikov
A V
AV
Laboratory for Neurogenomics of Behavior, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. akulikov@ngs.ru
Tikhonova
M A
MA
Chugui
V F
VF
Alekhina
T A
TA
Kolpakov
V G
VG
Popova
N K
NK
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000633:toxicity*; D002375:Catalepsy / Q000209:etiology* / Q000235:genetics*; D004195:Disease Models, Animal; D007099:Imipramine / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine