title: Plasma concentration for optimal sedation and total body clearance of propofol in patients after esophagectomy.
abstract: The present study investigated plasma propofol concentration for optimal sedation and total body clearance in patients who required sedation for mechanical ventilation after esophagectomy. Seven patients after esophagectomy were enrolled in this study. Plasma propofol concentrations were measured with high performance liquid chromatography. Total body clearance was calculated from the steady-state concentration. The infusion rate of propofol for achieving the sedation score of level 3 (drowsy, responds to verbal stimulation) was 1.74 +/- 0.82 mg kg(-1) h(-1) (mean +/- SD, n = 7) when the plasma propofol concentration and the total body clearance were 0.85 +/- 0.24 microg ml(-1) and 1.83 +/- 0.54 l min(-1) (mean +/- SD, n =7), respectively.
authors.affiliation: Intensive Care Unit, Gunma University Hospital, Maebashi, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takizawa
authors.forename: Eri
authors.initials: E
authors.lastname: Sato
authors.forename: Koichi
authors.initials: K
authors.lastname: Nishikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hinohara
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Hiraoka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
authors.forename: Fumio
authors.initials: F
authors.lastname: Goto
authors.forename: Fumio
authors.initials: F
authors.lastname: Kunimoto
mesh_terms: D000328:Adult; D018686:Anesthetics, Intravenous / Q000097:blood* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D016292:Procedural Sedation; D016629:Esophagectomy; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D015742:Propofol / Q000097:blood* / Q000493:pharmacokinetics; D012121:Respiration, Artificial
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol