title: Genome sequence and attenuating mutations in West Nile virus isolate from Mexico.
abstract: The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.
authors.affiliation: University of Texas Medical Branch, Galveston, Texas 77555-0609, USA. d.beasley@utmb.edu
authors.forename: David W C
authors.initials: DW
authors.lastname: Beasley
authors.forename: C Todd
authors.initials: CT
authors.lastname: Davis
authors.forename: Jose
authors.initials: J
authors.lastname: Estrada-Franco
authors.forename: Roberto
authors.initials: R
authors.lastname: Navarro-Lopez
authors.forename: Arturo
authors.initials: A
authors.lastname: Campomanes-Cortes
authors.forename: Robert B
authors.initials: RB
authors.lastname: Tesh
authors.forename: Scott C
authors.initials: SC
authors.lastname: Weaver
authors.forename: Alan D T
authors.initials: AD
authors.lastname: Barrett
mesh_terms: D000818:Animals; D001483:Base Sequence; D005260:Female; D016679:Genome, Viral; D008800:Mexico; D051379:Mice; D009154:Mutation; D014774:Virulence / Q000235:genetics; D014902:West Nile virus / Q000235:genetics* / Q000472:pathogenicity