title: Radiation risk is linear with dose at low doses.
abstract: This paper presents a brief argument, based on a mechanistic approach, to show that radiation risk is linear with radiation dose from zero dose up. Similarities in cellular effects lead to the assumption of a common mechanism and the DNA double strand break is identified as the crucial radiation-induced lesion. A cancer model extends the cellular effects to the main radiation risk providing confirmation of the dose effect for cancer at low doses.
authors.affiliation: Ellerbank, Cowan Head, Kendal, Cumbria LA8 9HX, UK.
authors.forename: K H
authors.initials: KH
authors.lastname: Chadwick
authors.forename: H P
authors.initials: HP
authors.lastname: Leenhouts
mesh_terms: D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009154:Mutation / Q000528:radiation effects; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology*; D012307:Risk Factors
chemical_list: D004247:DNA