title: Synchronous anal and penile cancers.
abstract: Malignancies of the anogenital region have similar etiology, including viral infections, sexual habits, social and educational factors. Condylomata acuminata represent precancerous lesions. In the available literature, we found no cases of synchronous cancers of anus and penis reported. We report a case of synchronous cancer of the penile foreskin and cancer of the anus in a 36 year-old man. The microscopic diagnosis of the anal lesion was squamous cell cancer, basaloid type. The penile lesion was squamous cell cancer, keratinizing type. Both cancers presented with the in situ component. Immunohistochemical staining (MIB-1) and histological features (koilocytosis, acanthosis and dyskeratosis) indirectly confirmed the past viral infection. Numerous etiological similarities in anogenital cancers entail careful clinical inspection in patients with a malignant lesion in this region and suggest searching for possible other concomitant cancers or precancerous lesions.
authors.affiliation: Department of Surgical Oncology, Maria Skłodowska-Curie Memorial Institute for Oncology, Cancer Center, ul. Garncarska 11, 31-115 Kraków, Poland. z5wysock@cyf-kr.edu.pl
authors.forename: Wojciech M
authors.initials: WM
authors.lastname: Wysocki
authors.forename: Andrzej L
authors.initials: AL
authors.lastname: Komorowski
authors.forename: Leszek S
authors.initials: LS
authors.lastname: Kolodziejski
authors.forename: Joanna
authors.initials: J
authors.lastname: Wysocka
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology; D003218:Condylomata Acuminata / Q000473:pathology; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery / Q000821:virology; D018307:Neoplasms, Squamous Cell / Q000473:pathology* / Q000601:surgery / Q000821:virology; D010412:Penile Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology; D011230:Precancerous Conditions / Q000473:pathology