title: Invasive epithelial mesothelioma in a dog.
abstract: This report describes the gross, microscopic, and immunohistochemical features of an invasive epithelial mesothelioma in an 11-year-old neutered male Golden Retriever. The tumor involved the pericardium, pleura, mediastinum, and peritoneum and invaded into submesothelial tissues. Neoplastic cells in the thoracic fluid showed prominent features of malignancy in a background of mixed inflammatory cells and scattered erythrocytes. Histologically, the tumor consisted of nests of epithelioid cells with frequent mitotic figures and multinucleation that infiltrated submesothelial tissues. Neoplastic cells strongly coexpressed vimentin and cytokeratin intermediate filaments, which assisted in the differentiation from other epithelial tumors of nonmesothelial origin.
authors.affiliation: Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada. freggeti@uoguelph.ca
authors.forename: F
authors.initials: F
authors.lastname: Reggeti
authors.forename: B
authors.initials: B
authors.lastname: Brisson
authors.forename: K
authors.initials: K
authors.lastname: Ruotsalo
authors.forename: E
authors.initials: E
authors.lastname: Southorn
authors.forename: D
authors.initials: D
authors.lastname: Bienzle
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D013899:Thoracic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin