title: Effect of microhydrin on blood lactate, protein carbonyls, and glutathione status in rats before and after aerobic exercise.
abstract: To examine the effects of an antioxidant treatment on blood lactate, protein carbonyls (PC), and glutathione status, 42 male rats were assigned to either a control treatment (water, C) or one of two Microhydrin treatments (added to water, MH I or MH II). Rats from each treatment were assigned to either exercise (60 min of running) or rest. A treatment-by-time interaction was noted for blood lactate, with elevations only in the C and MH I treatments post-exercise (approximately 2.54 and 2.5 mM, respectively). Both treatment and time main effects were noted for PC. Exercise resulted in an increase in PC for both Microhydrin treatments with significantly greater PC compared to C. Total blood glutathione was unaffected by treatment or exercise. Exercise increased the ratio of oxidized to total glutathione and the MH II treatment resulted in a greater ratio compared to the other treatments. In conclusion, MH II results in lower blood lactate, while resulting in an increase in the concentration of oxidized protein and glutathione, suggesting heightened oxidative stress.
authors.affiliation: Dept of Exercise and Sport Science, The University of North Carolina at Greensboro, Greensboro, NC 27402-6169, USA.
authors.forename: Allan H
authors.initials: AH
authors.lastname: Goldfarb
authors.forename: Richard
authors.initials: R
authors.lastname: Bloomer
authors.forename: Michael J
authors.initials: MJ
authors.lastname: McKenzie
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005978:Glutathione / Q000097:blood* / Q000378:metabolism; D019803:Glutathione Disulfide / Q000097:blood; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011506:Proteins / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species; D017640:Silicates / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D011506:Proteins; D017382:Reactive Oxygen Species; D017640:Silicates; C487012:silica hydride; D019344:Lactic Acid; D005978:Glutathione; D019803:Glutathione Disulfide