title: The role of salivary lipocalins in blood feeding by Rhodnius prolixus.
abstract: In order to overcome host mechanisms that prevent blood loss, the blood-sucking bug Rhodnius prolixus has evolved a complex salivary secretion containing dozens of different proteins. A number of these have been characterized and found to have roles in inhibiting various hemostatic or inflammatory systems. Interestingly, many of these biologically active salivary proteins belong to the lipocalin protein family. A proliferation of lipocalin genes has occurred via gene duplication and subsequent divergence. Functional genomic, proteomic, and functional studies have been performed to probe the role of salivary lipocalins in blood feeding. In the course of these investigations, anticoagulant, antiplatelet, antiinflammatory, and vasodilatory molecules have been described.
authors.affiliation: Laboratory of Malaria and Vector Research, National Institutes of Health, NIAID, Rockville, Maryland 20852, USA. jandersen@niaid.nih.gov
authors.forename: John F
authors.initials: JF
authors.lastname: Andersen
authors.forename: Nanda P
authors.initials: NP
authors.lastname: Gudderra
authors.forename: Ivo M B
authors.initials: IM
authors.lastname: Francischetti
authors.forename: José M C
authors.initials: JM
authors.lastname: Ribeiro
mesh_terms: D000595:Amino Acid Sequence; D000821:Animal Feed; D000818:Animals; D001769:Blood; D002352:Carrier Proteins / Q000235:genetics* / Q000502:physiology*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D012239:Rhodnius / Q000502:physiology*; D012463:Saliva / Q000502:physiology*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D002352:Carrier Proteins