A lipid dependence in the formation of twin ion channels.
A gramicidin A derivative with a polyether linkage between both ethanolamine termini was synthesized and its ion channel properties were studied. The compound showed a duplication in the state of conductance for alkali cations in thick DOPC bilayer membranes, which is interpreted as the occurrence of twin-channels. In thinner DMPC membranes mono-channels were dominant. The influence of hydrophobic coupling on the mono channel/twin channel equilibrium is discussed.
Al-Momani
Lo'ay
L
Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein Strasse, D-35032 Marburg, Germany.
Reiss
Philipp
P
Koert
Ulrich
U
D019281:Dimerization; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D004553:Electric Conductivity; D006096:Gramicidin / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D015640:Ion Channel Gating; D007473:Ion Channels / Q000737:chemistry*; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000737:chemistry*; D008567:Membranes, Artificial; D008956:Models, Chemical; D008958:Models, Molecular; D010713:Phosphatidylcholines / Q000737:chemistry*; D011487:Protein Conformation
D007473:Ion Channels; D008563:Membrane Lipids; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D006096:Gramicidin; C017251:1,2-oleoylphosphatidylcholine; D004134:Dimyristoylphosphatidylcholine