title: Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection.
abstract: Infections of T cells and natural killer (NK) cells play a central role in the pathogenesis of chronic active Epstein-Barr virus (CAEBV) infection. To characterize the virologic and cytokine profiles of T cell-type and NK cell-type infection, 39 patients with CAEBV infection were analyzed. Patients with T cell-type infection had higher titers of immunoglobulin G against early and late EBV antigens, suggesting lytic cycle infection. However, the pattern of EBV gene expression was latency type II; BZLF1, which is a hallmark of lytic cycle infection, could not be detected in any patients, regardless of infection type. Patients with CAEBV infection had high concentrations of proinflammatory, T helper cell type 1, and anti-inflammatory cytokines. The cytokine profile in patients with NK cell-type infection was similar to that in patients with T cell-type infection, but the concentration of IL-13 was high in patients with NK cell-type infection. These findings should help to clarify the pathogenesis of CAEBV infection and facilitate the development of more-effective treatments.
authors.affiliation: Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. hkimura@med.nagoya-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
authors.forename: Yo
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Shinya
authors.initials: S
authors.lastname: Hara
authors.forename: Naomi
authors.initials: N
authors.lastname: Sugaya
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kawada
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Shibata
authors.forename: Seiji
authors.initials: S
authors.lastname: Kojima
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Nagasaka
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kuzushima
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Morishima
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood; D004268:DNA-Binding Proteins / Q000097:blood; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D018793:Interleukin-13 / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology / Q000821:virology*; D016131:Lymphocyte Subsets / Q000276:immunology / Q000821:virology; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology*; D015534:Trans-Activators / Q000097:blood; D014764:Viral Proteins / Q000097:blood
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; C063676:BZLF1 protein, Herpesvirus 4, Human; D016207:Cytokines; D004268:DNA-Binding Proteins; D007074:Immunoglobulin G; D018793:Interleukin-13; D015534:Trans-Activators; D014764:Viral Proteins