title: A new facile chemoenzymatic synthesis of levamisole.
abstract: An efficient and facile chemoenzymatic synthesis of levamisole by employing lipase-mediated resolution of 3-hydroxy-3-phenylpropanenitrile followed by its conversion to beta-amino alcohol as the key intermediate is described.
authors.affiliation: Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.res.in
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: G B Ramesh
authors.initials: GB
authors.lastname: Khanna
authors.forename: T
authors.initials: T
authors.lastname: Krishnaji
authors.forename: R
authors.initials: R
authors.lastname: Ramu
mesh_terms: D000085:Acetates / Q000737:chemistry; D000438:Alcohols / Q000737:chemistry; D006801:Humans; D007978:Levamisole / Q000138:chemical synthesis*; D008049:Lipase / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000085:Acetates; D000438:Alcohols; D009570:Nitriles; D007978:Levamisole; D008049:Lipase