[Experimental evaluation of delivery means of potential anti-HIV microbicides].
The purpose was to develop an effective drug of local intravaginal membranetropic microbicide based on polycarboxylate and matrix modified by norbonene and/or peptide (simulator of CCR5 coreceptor). The drug was added to the composition of polyacrykic acid-polyvinylpyrrolidone (interpolymer complexes) in order to prevent the interplay of its non-specific groups with proteins. The antiviral effect and absence of toxicity of the finished microbicide form were demonstrated on the human lymphoid MT-4 culture.
Perminova
N G
NG
Varaksin
N A
NA
Riabicheva
T G
TG
Larionov
P M
PM
Timofeev
D I
DI
Timofeev
I V
IV
D000180:Acrylic Resins / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D002460:Cell Line; D004337:Drug Carriers / Q000494:pharmacology* / Q000633:toxicity; D016503:Drug Delivery Systems; D015497:HIV-1 / Q000187:drug effects*; D008081:Liposomes; D008214:Lymphocytes / Q000187:drug effects / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D011205:Povidone / Q000494:pharmacology / Q000633:toxicity
D000180:Acrylic Resins; D019380:Anti-HIV Agents; D004337:Drug Carriers; D008081:Liposomes; C006903:carbopol 940; D011205:Povidone