The immunogenetics of pemphigus vulgaris.
Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin of unknown etiology. While various environmental factors have been implicated as triggering agents, HLA association is probably the most important predisposing factor. The aim of this review is to highlight the association of HLA with pemphigus vulgaris. In addition, we present recent results showing a possible association with the nonclassical HLA-G antigen.
Gazit
Ephraim
E
The Tissue Typing Laboratory, Sheba Medical Center, Tel-Hashomer, Ramat Gan 52621, Israel. egazit@post.tau.ac.il
Loewenthal
Ron
R
D015551:Autoimmunity / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D010392:Pemphigus / Q000235:genetics* / Q000276:immunology*