Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing.
Plasmodium falciparum MSP6 is a merozoite surface antigen that shows organization and sequence homologies similar to those of MSP3. Within its C-terminus conserved region, it presents some epitopes that are cross-reactive with MSP3 and others that are not, both being targets of naturally occurring antibodies that block the P. falciparum erythrocytic cycle in cooperation with monocytes.
Singh
Subhash
S
Bio-medical Parasitology Unit, Institute Pasteur, 28 rue du Dr Roux, 75015 Paris, France.
Soe
Soe
S
Roussilhon
Christian
C
Corradin
Giampietro
G
Druilhe
Pierre
P
D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000953:Antigens, Protozoan / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006801:Humans; D016778:Malaria, Falciparum / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology*; D008969:Molecular Sequence Data; D009000:Monocytes / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*
D000906:Antibodies; D000953:Antigens, Protozoan; D000939:Epitopes; D008565:Membrane Proteins; D015800:Protozoan Proteins; C089133:merozoite surface protein 3, Plasmodium; C435213:merozoite surface protein 6, Plasmodium