Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation.
The anti-tumor activity of the immune system in the setting of hematopoietic stem cell transplantation has largely been described in the context of the "graft-versus-tumor" effect of allogeneic stem cell transplantation. This article reviews clinical evidence suggesting the existence of an autologous graft-versus-tumor effect in the setting of host immune system recovery following autologous stem cell transplantation resulting in prolongation of survival of cancer patients.
Porrata
L F
LF
Division of Hematology, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Markovic
S N
SN
D020350:Graft vs Tumor Effect / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007121:Immunocompetence; D007694:Killer Cells, Natural / Q000276:immunology; D018655:Lymphocyte Count; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous