[Advances in therapy for ascites and hepatorenal syndrome].
Sequential diuretic treatment of ascites with spironolactone and furosemide is equivalent to initial combination therapy. Orally applicable vasopressin-V2-receptor antagonists are an interesting novel therapeutic approach for the elimination of free water. The therapeutic efficacy for patients with cirrhosis and ascites is currently being investigated in phase II trials. Following paracentesis of up to 6 liters volume, infusion of 3.5 % saline is as effective as 20 % albumin. Another trial confirms the superiority of TIPS for the treatment of massive ascites, also demonstrating survival benefit. Determination of leukocyte esterase activity with a simple stix method may be helpful for the rapid and easy diagnosis of spontaneous bacterial peritonitis. Patients with hepatorenal syndrome seem to benefit from a combination of terlipressin and albumin whereas the effect of albumin dialysis on survival remains to be proven.
Gerbes
A L
AL
Medizinische Klinik II, Klinikum der Ludwig-Maximilians-Universität, Grosshadern, München. gerbes@med2.uni-muenchen.de
Gülberg
V
V
D000818:Animals; D001201:Ascites / Q000175:diagnosis* / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000008:administration & dosage*; D006530:Hepatorenal Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000639:trends; D016896:Treatment Outcome
D004232:Diuretics