Effect of serotoninergic and cholinergic nervous systems and corresponding neurotransmitters on heart function and motor activity of pelvic smooth muscle organs.
Serotonin potentiated vagal negative chronotropic effect in rabbits and increased the synergistic action of autonomic nervous structures on cardiac function in frogs. Acetylcholine in low doses produced a positive chronotropic effect in frogs, which was related to activation of intracardiac adrenergic neurons. Simultaneous activation of the serotoninergic and cholinergic system suppressed heart function, but increased motor activity of pelvic smooth muscle organs.
Lychkova
A E
AE
Central Research Institute of Gastroenterology, Moscow.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000502:physiology; D004543:Ejaculatory Ducts / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010388:Pelvis; D011817:Rabbits; D011898:Ranidae; D012701:Serotonin / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D014599:Uterus / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology
D018377:Neurotransmitter Agents; D012701:Serotonin; D000109:Acetylcholine