In vitro regulation of cell behavior by calcium phosphates synthesized by the mechanochemical method.
Biological activity of eight hydroxyapatite powders synthesized by the mechanochemical method was studied in vitro. Introduction of copper and zinc atoms into synthetic hydroxyapatite structure promotes cell adhesion. Hydroxyapatites obtained by the mechanochemical method are promising base for a new class of materials and coatings with regulated bioactivity for orthopedics and traumatology.
Karlov
A V
AV
Center for Orthopedics and Medical Material Technology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. khl@comm.tomsk.ru
Khlusov
I A
IA
Pozhen'ko
N S
NS
Chaikina
M V
MV
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D017886:Durapatite / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008533:Megakaryocytes / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
D003300:Copper; D017886:Durapatite; D015032:Zinc