[Some important news in clinical nephrology in years 2003-2004].
A new classification of chronic renal diseases enables to stratify risk of complications of chronic renal insufficiency and cardiovascular diseases. Chronic renal diseases are not rare, their incidence increases with age. Main causes of morbidity and mortality of patients with chronic renal diseases are cardiovascular complications. Besides typical risk factors, patients with chronic renal disease are at risk of specific renal diseases (such as anaemia or hyperphosphatemia). A cardiovascular risk of renal patients also increases dislipidemia. Statin treatment is able to decrease not only cardiovascular morbidity and mortality but also to slow down progression of chronic renal insufficiency. Nondiabetic nephropathies progression also significantly decreases a combination of an angiotensin converting enzyme and an angiotensin antagonist. Also in patients with chronic glomerulonephritides treatment is currently indicated according to evidence based medicine. Some monoclonal antibodies (such as infliximab or rituximab) seem to be promising among new drugs.
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Klinika nefrologie 1. lékarské fakulty UK a VFN, Praha.
D002318:Cardiovascular Diseases / Q000150:complications; D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy