title: [Sustained clinical response of large hepatocellular carcinoma after chemoembolization with pirarubicin, amiodarone and Lipiodol].
abstract: Although chemoembolization is known to be an effective palliative treatment in hepatocellular carcinoma, it has a limited effect in large tumors. We report the case of a patient with a large hepatocellular carcinoma of the left liver who had a significant and sustained clinical response after six sessions of chemoembolization with a pirarubicin/amiodarone/lipiodol emulsion. Pirarubicin is an anthracycline which penetrates faster than doxorubicin into cancer cells. Amiodarone is a multidrug resistance inhibitor. Polysorbate 80, an excipient of injectable amiodarone stabilizes the anthracycline/lipiodol emulsion. The clinical efficacy of this new formulation could be evaluated in a phase II clinical trial.
authors.affiliation: Département d'Imagerie Médicale, CHU de Dijon.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Cercueil
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Ferrant
authors.forename: Nicolas
authors.initials: N
authors.lastname: Isambert
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Jouve
authors.forename: Michel
authors.initials: M
authors.lastname: Flesch
authors.forename: Denis
authors.initials: D
authors.lastname: Krause
authors.forename: Laurent
authors.initials: L
authors.lastname: Bedenne
authors.forename: Bruno
authors.initials: B
authors.lastname: Chauffert
mesh_terms: D000638:Amiodarone / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D003287:Contrast Media / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007269:Injections, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D003287:Contrast Media; D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D000509:alpha-Fetoproteins; D007459:Iodized Oil; D004317:Doxorubicin; C027260:pirarubicin; D000638:Amiodarone