Interleukin-1 beta gene polymorphism related with allergic pathogenesis in Iris constitution.
Iridological constitution has a strong familial aggregation and is implicated in heredity. The aetiology of inflammatory bowel disease is still unknown. However, from genetic epidemiological studies there is considerable evidence that genetic factors are associated with both Crohn's disease and ulcerative colitis. We investigated the relationships between Iridological constitution and interleukin 1 beta (IL-1beta) gene polymorphism. IL-1beta is a major proinflammatiry cytokine, and the polymorphisms of this gene have been shown to be of importance in a number of diseases. Especially, IL-1 has been suspected of involvement in allergic pathogenesis. Also, IL-1beta genotype is one of the genetic markers of gastric cancer. Therefore, we classified 166 individuals according to Iris constitution, and determined IL-1beta genotype. The frequencies of Iris constitutions as follows: neurogenic type, 41 (24.7%); abdominal connective tissue weakness type, 53 (31.9%); cardio-renal connective tissue weakness type, 50 (30.1%); the others type, 22 (13.3%). Especially, the frequency of abdominal connective tissue weakness type was higher in C/T genotype than in the remaining constitutions although the statistical power was very weak. Furthermore, we first attempted to explore possible involvement of the IL-1beta polymorphism and the Iris constitution.
Um
Jae-Young
JY
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
Do
Keum-Rok
KR
Hwang
Woo-Jun
WJ
Shin
Tae-Yong
TY
Hwang
Chung-Yeon
CY
Kim
Cheorl-Ho
CH
Kim
Yun-Kyung
YK
Hong
Seung-Heon
SH
Kim
Hyung-Min
HM
D000529:Complementary Therapies / Q000379:methods*; D005838:Genotype; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D007375:Interleukin-1 / Q000235:genetics*; D007498:Iris / Q000473:pathology*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D007375:Interleukin-1