title: Deteriorative effect of smoking on target lesion revascularization after implantation of coronary stents with diameter of 3.0 mm or less.
abstract: BACKGROUND
  Although smoking cessation is widely encouraged because of the associated risk of cardiovascular events, the impact of smoking on target lesion revascularization (TLR) after percutaneous coronary intervention (PCI) is controversial. Therefore, the present study retrospectively investigated the effect of smoking on TLR after plain-old balloon angioplasty (POBA; n=376) and stenting (STENT; n=434) in patients undergoing secondary coronary angiography at a single center.
  
  
  RESULTS
  A smoker was defined as current smoking or quitting within 2 years of the first PCI. In the POBA group, the predictors for TLR, as calculated by multiple logistic regression analysis, were a complex type of lesion (p<0.0001) and the left anterior descending artery (LAD) as affected vessel (p<0.05). In the STENT group, the predictors were the final % diameter of stenosis after stenting, measured by quantitative coronary arteriography (p<0.0005), LAD (p<0.01), and smoking (p=0.049). When the STENT group was divided into 2 groups according to the diameter of the implanted stent, smoking was a predictive factors for TLR in the group that received relatively small stents (diameter < or =3.0 mm) (p<0.02), but not in the group that received larger stents (diameter > or =3.5 mm).
  
  
  CONCLUSIONS
  Smoking has a deteriorative effect on TLR after implantation of relatively small coronary stents with a diameter of 3.0 mm or less.
authors.affiliation: Division of Cardiology, Saitama Cardiovascular and Respiratory Center, Kohnan, Japan. ishikawa@jikei.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yagi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ogawa
authors.forename: Chikara
authors.initials: C
authors.lastname: Mori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Mutoh
authors.forename: Atsushi
authors.initials: A
authors.lastname: Seo
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shibata
authors.forename: Satoru
authors.initials: S
authors.lastname: Yoshida
authors.forename: Kamon
authors.initials: K
authors.lastname: Imai
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Horie
authors.forename: Seibu
authors.initials: S
authors.lastname: Mochizuki
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000628:therapy; D009204:Myocardial Revascularization; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects*; D015607:Stents