Role of adrenal gland hormones in the mechanism of antiulcer action of nimesulide and ranitidine.
In the present study, we investigated whether the antiulcer effects of nimesulide (100 mg kg(-1) and ranitidine (150 mg kg(-1) were dependent on the adrenal cortex hormones. The antiulcer effects of nimesulide and ranitidine were examined in the indomethacin-induced gastric ulcer model in rats (first experiment). The mean ulcer areas in the control and ranitidine-treated groups were 11.1 +/- 3.18, 1.4 +/- 1.11 mm2, respectively. There was not any gastric damage in nimesulide-treated group. The mean ulcer area of control group (second experiment) administered metyrapone and indomethacin was 11.8 +/- 9.9, and it measured 2.0 +/- 1.41 mm2 in ranitidine-given group, while gastric damage was not observed in nimesulide-administered group. In adrenalectomized and indomethacin-treated rats (third experiment), the mean ulcer area was 17.9 +/- 11.5 mm2 in the nimesulide group, gastric ulcer was not seen in ranitidine group. In adrenalectomized rats (fourth experiment), the mean ulcer areas were 29 +/- 14.3, 23 +/- 11.2 and 1.3 +/- 2.4 mm2 in control group given indomethacin, only nimesulide or indomethacin + ranitidine, respectively. The obtained results indicated that adrenal cortex hormones played a role in antiulcer effect of nimesulide, but not ranitidine.
Süleyman
Halis
H
Atatürk University, Medical Faculty, Department of Pharmacology, TR-25240 Erzurum, Turkey. suleyman@atauni.edu.tr
Demircan
Berna
B
Göçer
Fatma
F
Halici
Zekai
Z
Hacimüftüoğlu
Ahmet
A
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000315:Adrenalectomy; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007213:Indomethacin / Q000633:toxicity; D008297:Male; D008797:Metyrapone; D011899:Ranitidine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D013449:Sulfonamides / Q000494:pharmacology*
D013449:Sulfonamides; D000450:Aldosterone; D011899:Ranitidine; C012655:nimesulide; D003345:Corticosterone; D007213:Indomethacin; D008797:Metyrapone