Extramedullary myeloid tumour (EMMT) of the gallbladder.
This report describes a rare case of an extramedullary myeloid tumour (EMMT) of the gallbladder in a patient without leukaemia. A 33 year old man visited a local hospital because of jaundice. Abdominal computed tomography revealed a tumorous mass measuring 6.0 x 4.5 cm and involving the entire gallbladder. A percutaneous needle biopsy was attempted, but because adenocarcinoma could not be completely ruled out, the use of undue force was considered dangerous. Under a preoperative diagnosis of gallbladder carcinoma, a hepatopancreatoduodenectomy was performed. The tumour cells exhibited various amounts of eosinophilic cytoplasm, had medium sized round nuclei with indentation and grooving, and were strongly immunoreactive for myeloperoxidase, CD43, and c-kit protein (CD117). After surgery, the patient underwent combination chemotherapy as prescribed for cases of acute myeloblastic leukaemia. The patient did not develop acute leukaemia during a follow up period of four years. In conclusion, a correct diagnosis of EMMT can be made using appropriate immunohistochemical staining.
Ojima
H
H
Pathology Division, National Cancer Centre Research Institute and Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 101-0045, Japan.
Hasegawa
T
T
Matsuno
Y
Y
Sakamoto
M
M
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D003131:Combined Modality Therapy / Q000379:methods; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D023981:Sarcoma, Myeloid / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
D015703:Antigens, CD