[The effect of two low dose oral contraceptive with gestodene on the systems of natural inhibitors of coagulation].
OBJECTIVE
The authors investigated the influence of two monophasic oral contraceptives with 30 and 20 microg ethynilestradiol (EE) with combination with 75 microg gestodene (GSD) upon the system of natural inhibitors of coagulation.


METHODS
The study is prospective for a period of 12 months and was conducted upon 105 clinically healthy women, who use 30 microg EE/75 microg GSD (n = 35), 20 microg EE/75 microg GSD (n = 35) and a control group (n = 35).


RESULTS
The continuous use of the contraceptive combination with 20 g EE/75 g GSD leads to statistically significant elevation of protein C (PrC), total protein S (TPrS) and Heparin Cofactor II (HCII). The use of the contraceptive combination with 30 microg EE/75 microg GSD is associated with statistically significant increase of Pr C and HC II. There were no statistically significant changes in the other variables.


CONCLUSIONS
The use of both oral contraceptive combinations is associated with increased anticoagulant activity, which status prevents from thrombosis.
Uchikova
E
E
Terzhumanov
R
R
Milchev
N
N
Iacheva
T
T
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D019774:Blood Coagulation Factor Inhibitors / Q000037:antagonists & inhibitors*; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000494:pharmacology*; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D009652:Norpregnenes / Q000008:administration & dosage*; D011446:Prospective Studies
D019774:Blood Coagulation Factor Inhibitors; D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D009652:Norpregnenes; C033273:Gestodene; D004997:Ethinyl Estradiol