title: Calpain-10 gene polymorphisms and type 2 diabetes in West Africans: the Africa America Diabetes Mellitus (AADM) Study.
abstract: OBJECTIVE
  To investigate whether the three single nucleotide polymorphisms (SNPs), SNP-43, -56, and -63 of CAPN10 were associated with type 2 diabetes in a West African cohort.
  
  
  METHODS
  A total of 347 diabetic subjects and 148 unaffected controls from four ethnic groups in two West African countries were enrolled in this study. After genotyping three SNPs of CAPN10 and one SNP from CYP19, the allele, genotype, and haplotype frequencies as well as the odds ratios were calculated to test their association with type 2 diabetes.
  
  
  RESULTS
  None of the alleles or genotypes was associated with type 2 diabetes. Although statistical analysis indicated that haplotype 221 was associated with type 2 diabetes (OR, 3.765; 95% CI, 1.577-8.989) in the two ethnic groups of Nigeria, the same haplotype did not show any association with type 2 diabetes in the two ethnic groups in Ghana (OR, 0.906; 95% CI, 0.322-2.552).
  
  
  CONCLUSIONS
  Considering the relatively low frequency of haplotype 221 and that none of the haplotypes including 221 was associated with any of the diabetes-related quantitative traits tested, it is concluded that SNP-43, -56, and -63 of the CAPN10 gene variants may play a limited role in the risk of type 2 diabetes risks in this cohort of West Africans.
authors.affiliation: College of Medicine, National Human Genome Center at Howard University, Washington, DC 20059, USA.
authors.forename: Yuanxiu
authors.initials: Y
authors.lastname: Chen
authors.forename: Rick
authors.initials: R
authors.lastname: Kittles
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Guanjie
authors.initials: G
authors.lastname: Chen
authors.forename: Adebowale
authors.initials: A
authors.lastname: Adeyemo
authors.forename: Ramesh K
authors.initials: RK
authors.lastname: Panguluri
authors.forename: Weidong
authors.initials: W
authors.lastname: Chen
authors.forename: Albert
authors.initials: A
authors.lastname: Amoah
authors.forename: Victoria
authors.initials: V
authors.lastname: Opoku
authors.forename: Joseph
authors.initials: J
authors.lastname: Acheampong
authors.forename: Kofi
authors.initials: K
authors.lastname: Agyenim-Boateng
authors.forename: Benjamin Ackon
authors.initials: BA
authors.lastname: Eghan
authors.forename: Awuah
authors.initials: A
authors.lastname: Nyantaki
authors.forename: Johnnie
authors.initials: J
authors.lastname: Oli
authors.forename: Godfrey
authors.initials: G
authors.lastname: Okafor
authors.forename: Esther
authors.initials: E
authors.lastname: Ofoegbu
authors.forename: Babatunde
authors.initials: B
authors.lastname: Osotimehin
authors.forename: Fayeofori
authors.initials: F
authors.lastname: Abbiyesuku
authors.forename: Thomas
authors.initials: T
authors.lastname: Johnson
authors.forename: Olufemi
authors.initials: O
authors.lastname: Fasanmade
authors.forename: Theresa
authors.initials: T
authors.lastname: Rufus
authors.forename: Paulette
authors.initials: P
authors.lastname: Furbert-Harris
authors.forename: Harold I
authors.initials: HI
authors.lastname: Daniel
authors.forename: Kate A
authors.initials: KA
authors.lastname: Berg
authors.forename: Francis S
authors.initials: FS
authors.lastname: Collins
authors.forename: Georgia M
authors.initials: GM
authors.lastname: Dunston
authors.forename: Charles N
authors.initials: CN
authors.lastname: Rotimi
mesh_terms: D000483:Alleles; D044383:Black People / Q000235:genetics; D002154:Calpain / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005869:Ghana / Q000453:epidemiology; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D002154:Calpain; C415197:calpain 10