Scientific evidence to support a vitamin E and heart disease health claim: research needs.
In addition to epidemiologic studies suggesting a benefit for high intakes of alpha-tocopherol, studies following supplementation in humans have clearly shown that alpha-tocopherol decreases lipid peroxidation, platelet aggregation, and functions as a potent anti-inflammatory agent. However, prospective human clinical trials with alpha-tocopherol alone and in combination with other antioxidants have been largely negative. In this review, we critically appraise the various clinical trials and provide recommendations for future research.
Jialal
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I
Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, University of California-Davis, Sacramento, CA, USA. ishwarlal.jialal@ucdmc.ucdavis.edu
Devaraj
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S
D000975:Antioxidants / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002986:Clinical Trials as Topic; D019587:Dietary Supplements; D006331:Heart Diseases / Q000517:prevention & control*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000517:prevention & control; D014810:Vitamin E
D000975:Antioxidants; D014810:Vitamin E