title: Diagnostic yield and therapeutic implications of capsule endoscopy in obscure gastrointestinal bleeding.
abstract: OBJECTIVE
  The main aim of this study was to evaluate efficacy and therapeutic impact of capsule endoscopy (CE) in obscure gastrointestinal bleeding (OGIB). In addition, we evaluated the software of automatic detection of red zones (SBI, Given Imaging).
  
  
  METHODS
  From June 2002 to June 2003, thirty-five patients with OGIB underwent capsule endoscopy after negative upper and lower digestive endoscopy. Capsule endoscopy was performed following a 12-hour fasting period and some received 2 L of PEG the night before for bowel preparation.
  
  
  RESULTS
  CE was performed for occult (N=18) or overt (N=17) OGIB. Potentially bleeding lesions were found in 16/35 patients (45.7%). Lesions were angiodysplasias (N=8), ulcerations (N=4), tumors (N=2) and active bleeding without visible lesion (N=2). Lesions were located in gastric antrum (N=1), duodenum (N=2) and jejuno-ileum (N=13). Endoscopic (N=10), surgical (N=2) or medical (N=1) treatments were performed in 13/35 (37%). SBI was retrospectively evaluated in 24 patients with sensitivity, specificity, positive and negative predictive value of respectively 45%, 73%, 50% and 69%. CE retention during 10 days occurred in a patient with a small bowel NSAID-induced stricture.
  
  
  CONCLUSIONS
  CE is a safe and effective procedure in the management of OGIB and had a therapeutic impact in more than one third of patients.
authors.affiliation: Département d'Hépatogastroentérologie et de Nutrition, Groupe de Recherche sur l'Appareil Digestif EA 3234, Hôpital C. Nicolle, 1 rue de Germont, 76031 Rouen Cedex.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Ben Soussan
authors.forename: Michel
authors.initials: M
authors.lastname: Antonietti
authors.forename: Sophie
authors.initials: S
authors.lastname: Hervé
authors.forename: Guillaume
authors.initials: G
authors.lastname: Savoye
authors.forename: Simon
authors.initials: S
authors.lastname: Ramirez
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lecleire
authors.forename: Philippe
authors.initials: P
authors.lastname: Ducrotté
authors.forename: Eric
authors.initials: E
authors.lastname: Lerebours
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020776:Endoscopes, Gastrointestinal; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged