Endothelial progenitor cells for vasculogenesis.
Postnatal vasculogenesis is considered to be involved in neovascularization of adult tissues, because bone marrow-derived endothelial progenitor cells (EPCs) were isolated from circulating mononuclear cells in peripheral blood and were shown to incorporate into sites of physiological and pathological neovascularization and to differentiate into mature endothelial cells. EPCs might have an attractive potential therapeutic application for cardiovascular ischemic diseases as a novel cell-based strategy mainly via a vasculogenesis mechanism.
Murasawa
Satoshi
S
Department of Regenerative Medicine and Research, Kobe Institute of Biomedical Research and Innovation/RIKEN, Center for Developmental Biology, Kobe Japan. murasawa@ibri-kobe.org
Asahara
Takayuki
T
D000818:Animals; D042783:Endothelial Cells / Q000502:physiology*; D015316:Genetic Therapy; D006801:Humans; D007511:Ischemia / Q000601:surgery / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000209:etiology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*