title: Perspective: fundamental and clinical concepts on stem cell homing and engraftment: a journey to niches and beyond.
abstract: In many ways, the homing of hematopoietic stem cells to bone marrow and other tissues defines these cells and their immediate and long-term fates Once homed, an inevitable series of proliferative and differentiative events presumptively follows. These comments, of course, hold for both homing to marrow, or alternatively, to other nonmarrow tissues. In this review, we will specifically focus on homing and engraftment to bone marrow because this is the best-studied and clinically applicable system.
authors.affiliation: Department of Research, Roger Williams Medical Center, Providence, RI 02908-4735, USA. pquesenberry@rwmc.org
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Quesenberry
authors.forename: Gerald
authors.initials: G
authors.lastname: Colvin
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Abedi
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D002633:Chemotaxis; D006085:Graft Survival; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans