Physicochemical and release properties of pellets coated with Kollicoat SR 30 D, a new aqueous polyvinyl acetate dispersion for extended release.
Kollicoat SR 30 D is a new aqueous colloidal polyvinyl acetate dispersion used for extended release coatings. Kollicoat SR 30 D is stable against sedimentation, has a low viscosity (54 mPas) and a negative zeta potential of -23.2 mV because of the presence of the anionic surfactant, sodium dodecyl sulfate. Because of its low minimum film formation temperature (MFT = 18 degrees C), plasticizer addition and a thermal after-treatment (curing) of coated pellets was not required. Coated pellets showed no aging or curing effect. The rate of release could be easily adjusted by varying the coating level. A subcoating layer of the hydrophilic polymer, polyvinyl alcohol, between an ibuprofen-containing core and the Kollicoat SR coating prevented the diffusion of the lipophilic, low melting ibuprofen into the polymer coating during storage. The drug release from Kollicoat SR 30 D coated pellets was almost independent of the pH and ionic strength of release medium.
Dashevsky
A
A
College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, 12169 Berlin, Germany. dashevsk@zedat.fu-berlin.de
Wagner
K
K
Kolter
K
K
Bodmeier
R
R
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D004343:Drug Implants; D010316:Particle Size; D011145:Polyvinyls / Q000737:chemistry* / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D004343:Drug Implants; D011145:Polyvinyls; C013215:polyvinyl acetate