Multiple pathologies in a patient with a progressive neurodegenerative syndrome.
A woman presenting with levodopa responsive Parkinsonism developed rapidly progressive bulbar signs, quadriparesis, and upper and lower motor neurone signs. At necropsy, she was found to have three pathological diagnoses: amyotrophic lateral sclerosis, Parkinson's disease, and abundant tau-positive argyrophilic neuritic pathology, known as argyrophilic grain disease. This case raises the possibility that three distinct neuropathological diagnoses share a common aetiology.
Liang
T-W
TW
Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. liangtw@mail.med.upenn.edu
Forman
M S
MS
Duda
J E
JE
McCluskey
L
L
Trojanowski
J Q
JQ
Siderowf
A
A
D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000473:pathology*; D001344:Autopsy; D001927:Brain Diseases / Q000150:complications / Q000473:pathology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000473:pathology*; D016875:tau Proteins / Q000032:analysis
D016875:tau Proteins