title: Measurement of coronary lumen area using an impedance catheter: finite element model and in vitro validation.
abstract: The measurement of coronary lumen cross-sectional area (CSA) is important for coronary physiology and cardiology. The general objective of this study is to develop an accurate and reproducible method to measure the lumen CSA of left anterior descending (LAD) artery using an impedance or conductance catheter. The conductance catheter technique is based on a cylindrical model of the chamber of interest. The first aim of this study was to validate the assumptions of the cylindrical model using a finite-element analysis (FEA) of the conductance catheter in the lumen of the vessel that takes into account the conductance of current through the vessel wall and surrounding tissue (parallel conductance, Gp). The FEA was used to determine the heterogeneity of potential and electrical fields and to optimize the design of the catheter relative to the diameter of the vessel. An optimum relationship between vessel and catheter diameter was obtained based on FEA. The second aim was to validate the in vitro CSA of LAD artery obtained from the conductance catheter method using A-mode ultrasound (US). The present study offers a novel approach to correct for the Gp that involves the injection of two solutions of NaCl (0.5% and 1.5%) with known conductivities directly into the lumen of the coronary artery in a porcine heart. In six hearts obtained from a slaughterhouse, we showed that the CSA and Gp can be determined analytically from two Ohm's law-type algebraic equations (cylindrical model) that account for the parallel conductance. The mean difference in diameter between the conductance catheter using the proposed two-injection method and U.S. was -0.02. The root mean square error for the impedance measurements was 2.8% of the mean US diameter. The future application of this technique to the in vivo condition is discussed.
authors.affiliation: Department of Biomedical Engineering, University of California, 204 Rockwell Engineering Centre, Irvine, CA 92697-2715, USA. gkassab@uci.edu
authors.forename: Ghassan S
authors.initials: GS
authors.lastname: Kassab
authors.forename: Eugen R
authors.initials: ER
authors.lastname: Lontis
authors.forename: Hans
authors.initials: H
authors.lastname: Gregersen
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002138:Calibration; D002404:Catheterization / Q000295:instrumentation*; D003331:Coronary Vessels; D017097:Electric Impedance; D004594:Electrophysiology; D008955:Models, Cardiovascular; D012680:Sensitivity and Specificity