title: Neuroendocrine regulation of salivary IgA synthesis and secretion: implications for oral health.
abstract: Secretory immunoglobulin A (S-IgA) represents the main adaptive immune mechanism in the oral cavity. The regulation of secretion and synthesis of S-IgA is not only dependent on prior antigenic stimulation, but is also under strong neuroendocrine control. Thus, alterations in neuroendocrine functioning (such as induced by stress, exercise, pregnancy, menstrual cycle, and pharmacological interventions) may affect salivary IgA levels. This review deals with the neuroendocrine regulation of synthesis and secretion of salivary IgA and its potential role in the maintenance of oral health.
authors.affiliation: Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, NL-1018 BT Amsterdam, The Netherlands.
authors.forename: Wijnand
authors.initials: W
authors.lastname: Teeuw
authors.forename: Jos A
authors.initials: JA
authors.lastname: Bosch
authors.forename: Enno C I
authors.initials: EC
authors.lastname: Veerman
authors.forename: Arie V Nieuw
authors.initials: AV
authors.lastname: Amerongen
mesh_terms: D000818:Animals; D003731:Dental Caries / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000737:chemistry / Q000502:physiology*; D009055:Mouth / Q000382:microbiology / Q000821:virology; D009490:Neurosecretory Systems / Q000502:physiology*; D009909:Oral Health; D012463:Saliva / Q000378:metabolism / Q000502:physiology*
chemical_list: D007071:Immunoglobulin A, Secretory