Dialyzable carbosilane dendrimers as soluble supports for the functionalization of pyridine fragments via palladium-catalyzed coupling reactions.
[reaction: see text] The use of carbosilane (CS) dendrimers as soluble supports in liquid phase organic synthesis (LPOS) is described. Control of the three key steps is perfectly achieved by covalently binding a pyridine fragment to the soluble support, modifying it via coupling reactions, and releasing it at the end. Nanofiltration (dialysis) allows facile purification of the supported molecules after each step.
Le Nôtre
Jérôme
J
Debye Institute, Department of Metal-Mediated Synthesis and Homogeneous Catalysis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
Firet
Judith J
JJ
Sliedregt
Leo A J M
LA
van Steen
Bart J
BJ
van Koten
Gerard
G
Klein Gebbink
Robertus J M
RJ
D002384:Catalysis; D050091:Dendrimers; D003956:Dialysis; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D012995:Solubility; D014297:Trimethylsilyl Compounds / Q000737:chemistry
D050091:Dendrimers; D011725:Pyridines; D012821:Silanes; D014297:Trimethylsilyl Compounds; C504072:carbosilane; D010165:Palladium