title: Human exposure and internal dose assessments of acrylamide in food.
abstract: This review provides a framework contributing to the risk assessment of acrylamide in food. It is based on the outcome of the ILSI Europe FOSIE process, a risk assessment framework for chemicals in foods and adds to the overall framework by focusing especially on exposure assessment and internal dose assessment of acrylamide in food. Since the finding that acrylamide is formed in food during heat processing and preparation of food, much effort has been (and still is being) put into understanding its mechanism of formation, on developing analytical methods and determination of levels in food, and on evaluation of its toxicity and potential toxicity and potential human health consequences. Although several exposure estimations have been proposed, a systematic review of key information relevant to exposure assessment is currently lacking. The European and North American branches of the International Life Sciences Institute, ILSI, discussed critical aspects of exposure assessment, parameters influencing the outcome of exposure assessment and summarised data relevant to the acrylamide exposure assessment to aid the risk characterisation process. This paper reviews the data on acrylamide levels in food including its formation and analytical methods, the determination of human consumption patterns, dietary intake of the general population, estimation of maximum intake levels and identification of groups of potentially high intakes. Possible options and consequences of mitigation efforts to reduce exposure are discussed. Furthermore the association of intake levels with biomarkers of exposure and internal dose, considering aspects of bioavailability, is reviewed, and a physiologically-based toxicokinetic (PBTK) model is described that provides a good description of the kinetics of acrylamide in the rat. Each of the sections concludes with a summary of remaining gaps and uncertainties.
authors.affiliation: Norwegian Institute of Public Health, Division of Environmental Medicine, P.O. Box 4404, Nydalen, NO-0403 Oslo, Norway.
authors.forename: E
authors.initials: E
authors.lastname: Dybing
authors.forename: P B
authors.initials: PB
authors.lastname: Farmer
authors.forename: M
authors.initials: M
authors.lastname: Andersen
authors.forename: T R
authors.initials: TR
authors.lastname: Fennell
authors.forename: S P D
authors.initials: SP
authors.lastname: Lalljie
authors.forename: D J G
authors.initials: DJ
authors.lastname: Müller
authors.forename: S
authors.initials: S
authors.lastname: Olin
authors.forename: B J
authors.initials: BJ
authors.lastname: Petersen
authors.forename: J
authors.initials: J
authors.lastname: Schlatter
authors.forename: G
authors.initials: G
authors.lastname: Scholz
authors.forename: J A
authors.initials: JA
authors.lastname: Scimeca
authors.forename: N
authors.initials: N
authors.lastname: Slimani
authors.forename: M
authors.initials: M
authors.lastname: Törnqvist
authors.forename: S
authors.initials: S
authors.lastname: Tuijtelaars
authors.forename: P
authors.initials: P
authors.lastname: Verger
mesh_terms: D020106:Acrylamide / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001682:Biological Availability; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D004032:Diet; D004034:Diet Surveys; D005504:Food Analysis; D005511:Food Handling / Q000379:methods*; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D051381:Rats; D018570:Risk Assessment; D018675:Toxicity Tests
chemical_list: D015415:Biomarkers; D020106:Acrylamide