Cutaneous spindle cell carcinoma following basal cell carcinoma.
A spindle cell carcinoma arose three years after the seeming excision of a so-called "infiltrative" basal cell carcinoma (IBCC) in the cheek of an 87-year-old Japanese woman. The patent had no history of irradiation. The tumor was composed of short fascicles and whorling arrangements of spindle to polygonal cells without residual IBCC. Immunohistochemically, the tumor was positive for vimentin, cytokeratin 8 & 18, epithelial membrane antigen, and alpha-smooth muscle actin. Ultrastructurally, the tumor cells had tonofilaments and desmosomes. The patient died after a local recurrence with metastatic lesions in the lung and the neck lymph nodes that were indicated by CT scanning and MRI at nine months after diagnosis. This case and others support the concept that spindle cell carcinoma can pursue an aggressive clinical course.
Fukunaga
Masaharu
M
Department of Pathology, the Jikei University School of Medicine, Tokyo, Japan. maasafu@jikei.ac.jp
D000199:Actins / Q000032:analysis; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis; D018396:Mucin-1 / Q000032:analysis; D016609:Neoplasms, Second Primary; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000032:analysis
D000199:Actins; D014408:Biomarkers, Tumor; D018396:Mucin-1; D014746:Vimentin; D007633:Keratins