Shape discrimination by total curvature, with a view to cancer diagnostics.
This paper investigates the use of total curvature for shape discrimination of objects via profiles of their planar sections (not assumed to be star shaped). Methods of estimating total curvature from observation of a finite number of points on the boundary of the object are investigated, including a simple discrete approximation method and various interpolation methods. Total curvature is capable of revealing shape differences on a local scale, as demonstrated by the analysis of two data sets of malignant and normal or benign tumour cell nuclear profiles.
Gardner
R J
RJ
Department of Mathematics, Western Washington University, Bellingham, WA 98225-9063, USA. richard.gardner@wwu.edu
Hobolth
A
A
Jensen
E B V
EB
Sørensen
F B
FB
D000465:Algorithms; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D008545:Melanoma / Q000473:pathology*; D009508:Nevus, Pigmented / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*