New data on the involvement of ectodermal epithelium in extrathymic differentiation of human T-lymphocytes.
Thymalin accumulates only in young cells of the skin ectodermal epithelium and mucosa of the anterior portions of the digestive and respiratory systems. After appearance of keratin the cells no longer accumulate thymalin. Similarly as in the thymus, thymalin content in the ectodermal epithelium of the organs is subjected to age-associated involution.
Khlystova
Z S
ZS
Laboratory of Embryonal Histogenesis, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow.
Kalinina
I I
II
Shmeleva
S P
SP
D000328:Adult; D002454:Cell Differentiation / Q000502:physiology*; D004475:Ectoderm / Q000166:cytology*; D004847:Epithelial Cells / Q000502:physiology; D005260:Female; D006801:Humans; D007107:Immune System / Q000196:embryology*; D011247:Pregnancy; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000502:physiology; D013951:Thymus Hormones / Q000502:physiology*
D013951:Thymus Hormones; C032805:thymalin