Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.
In humans, the strong statistical association between fitness and survival suggests a link between impaired oxygen metabolism and disease. We hypothesized that artificial selection of rats based on low and high intrinsic exercise capacity would yield models that also contrast for disease risk. After 11 generations, rats with low aerobic capacity scored high on cardiovascular risk factors that constitute the metabolic syndrome. The decrease in aerobic capacity was associated with decreases in the amounts of transcription factors required for mitochondrial biogenesis and in the amounts of oxidative enzymes in skeletal muscle. Impairment of mitochondrial function may link reduced fitness to cardiovascular and metabolic disease.
Wisløff
Ulrik
U
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt. 3, 7489 Trondheim, Norway. ulrik.wisloff@medisin.ntnu.no
Najjar
Sonia M
SM
Ellingsen
Oyvind
O
Haram
Per Magnus
PM
Swoap
Steven
S
Al-Share
Qusai
Q
Fernström
Mats
M
Rezaei
Khadijeh
K
Lee
Sang Jun
SJ
Koch
Lauren Gerard
LG
Britton
Steven L
SL
D000273:Adipose Tissue; D000332:Aerobiosis; D000375:Aging; D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D001947:Breeding; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000502:physiology; D015444:Exercise; D017079:Exercise Tolerance; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology / Q000503:physiopathology; D008931:Mitochondria, Muscle / Q000378:metabolism / Q000502:physiology*; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D047495:PPAR gamma / Q000378:metabolism; D010805:Physical Conditioning, Animal; D005082:Physical Exertion; D051381:Rats; D012307:Risk Factors; D012420:Running; D012641:Selection, Genetic; D015534:Trans-Activators / Q000378:metabolism; D016277:Ventricular Function, Left
D007328:Insulin; D008055:Lipids; D047495:PPAR gamma; D015534:Trans-Activators