title: OVCA1: tumor suppressor gene.
abstract: OVCA1, also known as DPH2L1, is a tumor suppressor gene associated with ovarian carcinoma and other tumors. Ovca1 homozygous mutant mice die at birth with developmental delay and cell-autonomous proliferation defects. Ovca1 heterozygous mutant mice are tumor-prone but rarely develop ovarian tumors. OVCA1 appears to be the homolog of yeast DPH2, which participates in the first biosynthetic step of diphthamide, by modification of histidine on translation elongation factor 2 (EF-2). Yeast dph2 mutants are resistant to diphtheria toxin, which catalyses ADP ribosylation of EF-2 at diphthamide. Thus, there appears to be growing evidence implicating alterations in protein translation with tumorigenesis.
authors.affiliation: Faculty of Life Sciences, National Yang-Ming University, 155 Li Nong Street, Section 2, Shihpai, Taipei 112, Taiwan.
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Chen
authors.forename: Richard R
authors.initials: RR
authors.lastname: Behringer
mesh_terms: D000818:Animals; D006579:Heterozygote; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D015778:Minor Histocompatibility Antigens; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C485679:Dph1 protein, mouse; D015778:Minor Histocompatibility Antigens; D025521:Tumor Suppressor Proteins