title: Focus issue: diabetes--fighting fat on multiple fronts.
abstract: Diabetes, an increasing problem worldwide, involves both insulin resistance and deficiencies in insulin secretion. This week's issues of Science and Science's STKE explore genetic factors that predispose to the development of diabetes as well as the links between diabetes and obesity.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Adler
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology*; D016207:Cytokines / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D009765:Obesity / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011972:Receptor, Insulin / Q000502:physiology; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D007328:Insulin; D011972:Receptor, Insulin