Tramadol concentrations in blood and in cerebrospinal fluid in a neonate.
Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood-brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.
Allegaert
K
K
Department of Paediatrics, University Hospital, Gasthuisberg, Herestraat, Leuven, Belgium. karel.allegaert@uz.kuleuven.ac.be
de Hoon
J
J
Verbesselt
R
R
Devlieger
H
H
Tibboel
D
D
D000701:Analgesics, Opioid / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D019635:Neurosurgical Procedures; D014147:Tramadol / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics
D000701:Analgesics, Opioid; D014147:Tramadol