Magnetoelastic transducers for monitoring coagulation, clot inhibition, and fibrinolysis.
Magnetoelastic transduction has been used to detect and monitor the viscosity changes that occur during the biological reactions of coagulation and fibrinolysis. Magnetoelastic sensors can be used, because the characteristic resonance frequency of the magnetoelastic strip shifts in response to the changes in fluid viscosity. At a set frequency, the output signal can be obtained over time to develop a coagulation and/or dissolution profile, which display the change in viscosity of a plasma sample that has undergone either coagulation or fibrinolysis. For coagulation screening, an exogenous tissue factor is added to an anticoagulated plasma sample to initiate coagulation. Further studies were performed to investigate fibrinolysis through the addition of plasmin. Plasmin is used in two different ways-as a competitive inhibitor before the initiation of clotting and also as a protease to dissolve the previously formed clot. This method is a viable option for the monitoring of processes that are paramount to maintaining hemostasis.
Puckett
Libby G
LG
Department of Chemistry, University of Kentucky, Lexington, KY 40506-0055, USA.
Lewis
Jaime K
JK
Urbas
Aaron
A
Cui
Xiangdong
X
Gao
Dayong
D
Bachas
Leonidas G
LG
D000925:Anticoagulants / Q000008:administration & dosage; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology*; D001780:Blood Coagulation Tests / Q000379:methods; D001809:Blood Viscosity / Q000502:physiology*; D005341:Fibrinolysin; D005342:Fibrinolysis / Q000187:drug effects / Q000502:physiology*; D018056:Hemorheology / Q000379:methods; D006801:Humans; D008280:Magnetics; D013918:Thrombin Time / Q000379:methods*; D014159:Transducers; D014914:Whole Blood Coagulation Time / Q000379:methods*
D000925:Anticoagulants; D005341:Fibrinolysin