Treatment of severe tardive dystonia with pallidal deep brain stimulation.
In five patients with medically refractory tardive dystonia, continuous bilateral high-frequency stimulation of the globus pallidus internus was associated with a rapid (within 12 to 72 hours) and substantial (mean 87%, 10.7 SD of the motor part of the Burke-Fahn-Marsden Dystonia Rating Scale) improvement of dystonia and functional disability without adverse events.
Trottenberg
T
T
Department of Neurology, Charité Campus Virchow, Humboldt University, Berlin, Germany. thomas.trottenberg@charite.de
Volkmann
J
J
Deuschl
G
G
Kühn
A A
AA
Schneider
G-H
GH
Müller
J
J
Alesch
F
F
Kupsch
A
A
D000368:Aged; D017109:Akathisia, Drug-Induced / Q000188:drug therapy / Q000628:therapy*; D003131:Combined Modality Therapy; D046690:Deep Brain Stimulation; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008140:Lorazepam / Q000627:therapeutic use; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy; D008875:Middle Aged; D010865:Pilot Projects; D013997:Time Factors; D016896:Treatment Outcome
D008140:Lorazepam