title: Homocysteine and retinal vein occlusion: a population-based study.
abstract: OBJECTIVE
  To report population data on the association between homocysteinemia and retinal vein occlusion (RVO).
  
  
  METHODS
  Cross-sectional, population-based study.
  
  
  METHODS
  Total serum homocysteine (tHcy) was estimated in subjects attending the second Blue Mountains Eye Study (BMES) (n = 3509, aged >49 years). Its association with RVO (graded from retinal photographs) was examined.
  
  
  RESULTS
  Homocysteine was more strongly associated with RVO in younger than older participants. In those aged <70 years, homocysteine levels >15 micromol/l were associated with increased odds of RVO, odds ratio (OR) 3.76; 95% confidence interval (CI) 1.06-13.40, in multivariable-adjusted analyses. Each 1 micromol/l increase in homocysteine was associated with a 7% increased odds of RVO, OR 1.07; CI 0.99-1.17 (P = .08).
  
  
  CONCLUSIONS
  This population-based study showed that elevated serum homocysteine is associated with the presence of RVO, independent of other risk factors.
authors.affiliation: Center for Vision Research, Department of Ophthalmology, University of Sydney, Westmead, NSW, Australia.
authors.forename: Brian
authors.initials: B
authors.lastname: Chua
authors.forename: Annette
authors.initials: A
authors.lastname: Kifley
authors.forename: Tien Y
authors.initials: TY
authors.lastname: Wong
authors.forename: Paul
authors.initials: P
authors.lastname: Mitchell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012170:Retinal Vein Occlusion / Q000097:blood / Q000209:etiology*; D012307:Risk Factors
chemical_list: D006710:Homocysteine