title: Glucose reaction with fumonisin B1 partially reduces its toxicity in swine.
abstract: Acute and subacute intraperitoneal doses of fumonisin B(1) (FB(1)) were administered to test the efficacy of the FB(1)-glucose reaction products in detoxifying FB(1) in swine. In the acute study at 11 mumol of FB(1)/kg of body weight, five of six pigs administered FB(1) and four of six pigs administered FB(1)-glucose died from acute pulmonary edema. Analysis of weight gain, serum aspartate aminotransferase and gamma-glutamyltransferase, total cholesterol, and pathological evaluation did not provide evidence of protection against FB(1) toxicity by the FB(1)-glucose reaction products. In the subacute study at 5.5 mumol of FB(1)/kg of body weight, one pig administered FB(1) died from liver damage. Analysis of serum aspartate aminotransferase, gamma-glutamyltransferase, and total bilirubin showed protection against FB(1) toxicity by the FB(1)-glucose reaction products. The levels of sphinganine and sphinganine/sphingosine ratios in serum and liver as well as pathologic findings provided definitive evidence of protection against the FB(1) toxic effects by this detoxification procedure (p < 0.05).
authors.affiliation: Interdepartmental Toxicology Program, Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA 50011, USA.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Fernández-Surumay
authors.forename: Gary D
authors.initials: GD
authors.lastname: Osweiler
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Yaeger
authors.forename: Catherine C
authors.initials: CC
authors.lastname: Hauck
authors.forename: Suzanne
authors.initials: S
authors.lastname: Hendrich
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Murphy
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D037341:Fumonisins / Q000737:chemistry / Q000633:toxicity*; D005947:Glucose / Q000008:administration & dosage* / Q000737:chemistry; D008107:Liver Diseases / Q000517:prevention & control / Q000662:veterinary; D011654:Pulmonary Edema / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D037341:Fumonisins; C056933:fumonisin B1; D005947:Glucose