title: [NiFe]-Hydrogenase maturation endopeptidase: structure and function.
abstract: Hydrogenase maturation endopeptidases catalyse the terminal step in the maturation of the large subunit of [NiFe]-hydrogenases. They remove a C-terminal extension from the precursor of the subunit, triggering a conformational switch that results in the bridging of the Fe and Ni atoms of the metal centre via the thiolate of a cysteine residue and in closure of the centre. This review summarizes what is known about the structure of the protein, its substrate specificity and its possible reaction mechanism.
authors.affiliation: Department Biologie I, University of Munich, Maria-Ward-Strasse 1a, D-80638 Munich, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Theodoratou
authors.forename: R
authors.initials: R
authors.lastname: Huber
authors.forename: A
authors.initials: A
authors.lastname: Böck
mesh_terms: D006864:Hydrogenase / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: C043296:nickel-iron hydrogenase; D006864:Hydrogenase