Heart rate influences on repolarization duration and morphology in symptomatic versus asymptomatic KCNQ1 mutation carriers.
QT and Tp/Te intervals were longer in patients with LQT1 (n = 67) than in nonaffected subjects (n = 52) but did not differentiate symptomatic (n = 21) from asymptomatic patients (n = 46). At fast heart rate, the time to accumulate the last part of total T-wave area (the t50-97 interval) was longer in symptomatic carriers compared with asymptomatic patients (119 +/- 19 vs 106 +/- 15 ms, p <0.01). The latter group had significantly longer t50-97 intervals than nonaffected subjects (96 +/- 14 ms, p <0.01).
Extramiana
Fabrice
F
Service de Cardiologie, Groupe Hospitalier Lariboisière, Paris, France. fabrice.extramiana@lrb.ap-hop-paris.fr
Denjoy
Isabelle
I
Badilini
Fabio
F
Chabani
Iheb
I
Neyroud
Nathalie
N
Berthet
Myriam
M
Fressard
Véronique
V
Guicheney
Pascale
P
Beaufils
Philippe
P
Leenhardt
Antoine
A
Coumel
Philippe
P
Maison-Blanche
Pierre
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D002353:Carrier State; D016009:Chi-Square Distribution; D002648:Child; D015716:Electrocardiography, Ambulatory; D005260:Female; D005838:Genotype; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008133:Long QT Syndrome / Q000235:genetics* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics