title: [Control of hospital infection of influenza: administration of neuraminidase inhibitor and cohort isolation of influenza patients].
abstract: Influenza can spread rapidly to patients and staff in hospitals when influenza is introduced by visitors, staff, or patients. In order to prevent and control outbreaks of influenza in hospitals, systematic management is important. This consists of a rapid diagnostic test, cohort isolation and administration of neuraminidase inhibitor. In the 2002-2003 season, 53 elderly patients were admitted to our hospital under the control of the system. The mean age was 78.8 years. We set 2 isolation rooms (10 beds) for influenza patients. Patients were isolated in the room for three days, administered oseltamivir immediately. Oral oseltamivir was well tolerated. Mean hospital stay was 10.7 days. 36 cases developed complications requiring antibiotics, and one patient developed a catheter related infection. Under the system, we could avoid cross infection of influenza. In two cases, nose swabs were taken for virus isolation every 12 hours and a rapid decline in virus shedding was observed after treatment.
authors.affiliation: Department of Infectious Disease, Tokyo Metropolitan Geriatric Medical Center.
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Kosugi
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Yuri
authors.initials: Y
authors.lastname: Chimura
authors.forename: Megumi
authors.initials: M
authors.lastname: Annaka
authors.forename: Sumie
authors.initials: S
authors.lastname: Shibazaki
authors.forename: Keiko
authors.initials: K
authors.lastname: Adachi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Higuchi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Shinkai
authors.forename: Kenji
authors.initials: K
authors.lastname: Sadamasu
authors.forename: Yoshishige
authors.initials: Y
authors.lastname: Masuda
authors.forename: Takashi
authors.initials: T
authors.lastname: Inamatsu
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D003428:Cross Infection / Q000517:prevention & control*; D004196:Disease Outbreaks / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D053139:Oseltamivir; D010356:Patient Isolation / Q000379:methods*
chemical_list: D000081:Acetamides; D000998:Antiviral Agents; D053139:Oseltamivir; D009439:Neuraminidase