Coronary artery spasm induced by 5-fluorouracil.
The frequently used chemotherapeutic drug 5-fluorouracil (5-FU) is known to cause angina pectoris and arrhythmias; myocardial infarction and sudden cardiac death could occur. Potential reasons for these phenomena range from toxic/metabolic disturbances to coronary artery spasms. This report shows angiographically proven spasmophilia of the coronary arteries and contributes to the understanding of angina pectoris occurring during treatment with 5-FU. Thus, verapamil type calcium antagonists as well as nitrates should be administered primarily in patients with coronary artery disease and in all patients who had been symptomatic during 5-FU administration in order to prevent further episodes.
Alter
P
P
Philipps University of Marburg/Lahn, Department of Internal Medicine-Cardiology, Baldingerstrasse, 35033 Marburg, Germany. palter@med.uni-marburg.de
Herzum
M
M
Schaefer
J R
JR
Maisch
B
B
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use / Q000633:toxicity*; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000187:drug effects; D003329:Coronary Vasospasm / Q000139:chemically induced* / Q000000981:diagnostic imaging; D004562:Electrocardiography / Q000187:drug effects; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D016629:Esophagectomy; D005080:Exercise Test / Q000187:drug effects; D005472:Fluorouracil / Q000008:administration & dosage / Q000633:toxicity*; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000633:toxicity; D008297:Male; D020360:Neoadjuvant Therapy / Q000009:adverse effects*; D012039:Regional Blood Flow / Q000187:drug effects
D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil