Solid phase synthesis of biohybrid block copolymers.
A new versatile route to synthesise biohybrid block copolymers is presented in which an amine terminated polymer is attached to an aldehyde functionalised resin, from which in subsequent steps the desired peptide can be grown using standard procedures.
Reynhout
Irene C
IC
Department of Organic Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
Löwik
Dennis W P M
DW
van Hest
Jan C M
JC
Cornelissen
Jeroen J L M
JJ
Nolte
Roeland J M
RJ
D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D001704:Biopolymers / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry
D000447:Aldehydes; D000588:Amines; D001704:Biopolymers; D010455:Peptides; D012117:Resins, Synthetic