Manipulation of innate immunity by bacterial pathogens.
The past decade has witnessed tremendous growth in two related fields: innate immunity and microbial pathogenesis. Many pathogens have evolved mechanisms to infect their hosts in the face of a fully functional innate immune system, and there are numerous examples by which pathogens avoid recognition and/or suppress inflammation. In this review, I suggest that pathogens not only survive the innate immune response, but use it to promote their pathogenesis.
Portnoy
Daniel A
DA
Department of Molecular and Cell Biology, 508 Barker Hall, University of California, Berkeley, Berkeley, CA 94703-3202, USA.
D000818:Animals; D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000276:immunology*; D005075:Biological Evolution; D006801:Humans; D007113:Immunity, Innate