Platination of nucleobases to enhance noncovalent recognition in protein-DNA/RNA complexes.
Fluorescence quenching experiments show that the stacking interaction between nucleic acid bases and l-tryptophan is enhanced significantly upon base coordination to a metal center such as Pt(II), and the biological implications of such enhancement are discussed.
Anzellotti
Atilio I
AI
Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284-2006, USA.
Ma
Erin S
ES
Farrell
Nicholas
N
D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014364:Tryptophan / Q000737:chemistry*
D009944:Organoplatinum Compounds; D011506:Proteins; D010984:Platinum; D012313:RNA; D014364:Tryptophan; D004247:DNA