The impact of extracellular acidosis on dendritic cell function.
Dendritic cells (DCs) are the most efficient antigen-presenting cells. They are activated in the periphery by conserved pathogen molecules and by inflammatory mediators produced by a variety of cell types in response to danger signals. It is widely appreciated that inflammatory responses in peripheral tissues are usually associated with the development of acidic microenvironments. Surprisingly, there are relatively few studies directed to analyze the effect of extracellular acidosis on the immune response. We focus on the influence of extracellular acidosis on the function of immature DCs. The results presented here show that acidosis activates DCs. It increases the acquisition of extracellular antigens for MHC class I-restricted presentation and the ability of antigen-pulsed DCs to induce both specific CD8+ CTL and B-cell responses. These findings may have important implications to our understanding of the mechanisms through which DCs sense the presence of infection or inflammation in nonlymphoid tissues.
Vermeulen
Mónica Elba
ME
Institute of Hematologic Research, National Academy of Medicine, Department of Microbiology, Buenos Aires University School of Medicine, Buenos Aires, Argentina.
Gamberale
Romina
R
Trevani
Analía Silvina
AS
Martínez
Diego
D
Ceballos
Ana
A
Sabatte
Juan
J
Giordano
Mirta
M
Geffner
Jorge Raúl
JR
D000138:Acidosis / Q000378:metabolism*; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D000941:Antigens / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D009369:Neoplasms / Q000378:metabolism; D010873:Pinocytosis / Q000276:immunology; D011946:Receptors, Antigen / Q000276:immunology
D000941:Antigens; D008565:Membrane Proteins; D011946:Receptors, Antigen