title: Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis.
abstract: We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The DeltalysA DeltapanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.
authors.affiliation: Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
authors.forename: Vasan K
authors.initials: VK
authors.lastname: Sambandamurthy
authors.forename: Steven C
authors.initials: SC
authors.lastname: Derrick
authors.forename: Kripa V
authors.initials: KV
authors.lastname: Jalapathy
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
authors.forename: Robert G
authors.initials: RG
authors.lastname: Russell
authors.forename: Sheldon L
authors.initials: SL
authors.lastname: Morris
authors.forename: William R
authors.initials: WR
authors.lastname: Jacobs
mesh_terms: D000818:Animals; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008239:Lysine / Q000378:metabolism; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000378:metabolism; D010205:Pantothenic Acid / Q000378:metabolism; D013997:Time Factors; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*; D032581:Tuberculosis Vaccines; D014613:Vaccines, Attenuated
chemical_list: D032581:Tuberculosis Vaccines; D014613:Vaccines, Attenuated; D010205:Pantothenic Acid; D008239:Lysine