Partially hydrolysed guar gum supplemented comminuted chicken diet in persistent diarrhoea: a randomised controlled trial.
BACKGROUND
Partially hydrolysed guar gum (Benefiber) added to a diet is fermented in the colon, producing short chain fatty acids, which improve intestinal function, including colonic salt and water absorption.


OBJECTIVE
To evaluate the effect of Benefiber supplemented comminuted chicken diet in the treatment of persistent diarrhoea.


METHODS
One hundred and sixteen children (aged 5-24 months), presenting to Dhaka Hospital with a history of watery diarrhoea for more than 14 days (persistent diarrhoea), were randomised to receive either: (1) comminuted chicken diet with Benefiber (study diet); or (2) comminuted chicken diet without Benefiber (control diet). The study period was seven days.


RESULTS
Of 116 children, 57 received the study diet and 59 received the control diet. Diarrhoea resolved in a greater number of children with the study than with the control diet (46/55 (84%) v 36/58 (62%); odds ratio 3.12, 95% CI 1.19 to 8.4). Survival analysis for the duration of diarrhoea also showed a reduced duration of diarrhoea in children receiving the study diet. There was also a trend in daily stool reduction in children receiving the study diet, significant on days 4-7.


CONCLUSIONS
Results show that Benefiber supplemented comminuted chicken diet enhances recovery of children with persistent diarrhoea, indicating its therapeutic potential.
Alam
N H
NH
International Centre for Diarrhoeal Disease Research, GPO Box 128, Dhaka 1000, Bangladesh. nhalam@icddrb.org
Meier
R
R
Sarker
S A
SA
Bardhan
P K
PK
Schneider
H
H
Gyr
N
N
D000818:Animals; D002645:Chickens; D003672:Defecation / Q000502:physiology; D003968:Diarrhea, Infantile / Q000178:diet therapy* / Q000503:physiopathology; D004043:Dietary Fiber / Q000008:administration & dosage; D019587:Dietary Supplements; D005685:Galactans / Q000008:administration & dosage*; D006801:Humans; D006868:Hydrolysis; D007223:Infant; D008297:Male; D008351:Mannans / Q000008:administration & dosage*; D053149:Plant Gums; D013997:Time Factors; D016896:Treatment Outcome
D004043:Dietary Fiber; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; C007894:guar gum