title: Microbiology. TB--a new target, a new drug.
authors.affiliation: Génétique Moléculaire Bactérienne and Biochimie Structurale Units, Institut Pasteur, Paris 75724 Cedex 15, France. stcole@pasteur.fr
authors.forename: Stewart T
authors.initials: ST
authors.lastname: Cole
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Alzari
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D025243:Bacterial Proton-Translocating ATPases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D017322:Clinical Trials, Phase II as Topic; D064687:Diarylquinolines; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D024881:Drug Resistance, Bacterial; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D020102:Mycobacterium smegmatis / Q000187:drug effects / Q000235:genetics; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D017433:Protein Structure, Secondary; D018892:Proton-Motive Force; D006180:Proton-Translocating ATPases / Q000737:chemistry / Q000378:metabolism; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D064687:Diarylquinolines; D004791:Enzyme Inhibitors; D011804:Quinolines; C493870:bedaquiline; D000255:Adenosine Triphosphate; D025243:Bacterial Proton-Translocating ATPases; D006180:Proton-Translocating ATPases