Acute polymyositis after donor lymphocyte infusion.
Polymyositis usually occurred along with other manifestations of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) had been reported. However, polymyositis with a sole manifestation of acute GVHD following donor lymphocyte infusion (DLI) is rare. We reported a 45-yr-old man of acute lymphoid leukemia post-allogeneic HSCT 6 months developed acute polymyositis after DLI. He did not develop any symptoms, signs of acute or chronic GVHD following allogeneic HSCT, despite withdraw of immuosuppresive agents, cyclosporin A (CsA). As the DNA-STR of bone marrow analysis showed mixed chimerism, he received the DLI for remission on May 16, 2002. Acute polymyositis developed following DLI 22 d later. The clinical presentation of polymyositis is compatible with a manifestation of acute GVHD following DLI. It also responds to the treatment of steroid and CsA.
Lin
Peng-Chan
PC
Department of Medical Oncology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan.
Hsiao
Liang-Tsai
LT
Chen
Po-Min
PM
D016572:Cyclosporine / Q000008:administration & dosage; D004198:Disease Susceptibility / Q000276:immunology; D006086:Graft vs Host Disease / Q000517:prevention & control; D006684:HLA-DR Antigens; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D017710:Lymphocyte Transfusion / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D017285:Polymyositis / Q000188:drug therapy / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000276:immunology / Q000628:therapy*; D013256:Steroids / Q000008:administration & dosage; D013997:Time Factors; D018183:Transplantation Chimera; D014184:Transplantation, Homologous
D006684:HLA-DR Antigens; D007166:Immunosuppressive Agents; D013256:Steroids; D016572:Cyclosporine