Synthesis of isoquinoline derivatives using ROM-RCM of cyclobutene-yne.
Isoquinoline derivatives were synthesized from cyclobutenylmethylamine derivatives having an alkyne moiety in a tether using a second-generation ruthenium carbene complex under ethylene gas in good yields.
Mori
Miwako
M
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. mori@pharm.hokudai.ac.jp
Wakamatsu
Hideaki
H
Tonogaki
Keisuke
K
Fujita
Reiko
R
Kitamura
Tsuyoshi
T
Sato
Yoshihiro
Y