title: Development of PPO inhibitor-resistant cultures and crops.
abstract: Recent progress in the development of protoporphyrinogen oxidase (PPO, Protox) inhibitor-resistant plant cell cultures and crops is reviewed, with emphasis on the molecular and cellular aspects of this topic. PPO herbicide-resistant maize plants have been reported, along with the isolation of plant PPO genes and the isolation of herbicide-resistant mutants. At the same time, PPO inhibitor-resistant rice plants have been developed by expression of the Bacillus subtilis PPO gene via targeting the gene into either chloroplast or cytoplasm. Other attempts to develop PPO herbicide-resistant plants include conventional tissue culture methods, expression of modified co-factors of the protoporphyrin IX binding subunit proteins, over-expression of wild-type plant PPO gene, and engineering of P-450 monooxygenases to degrade the PPO inhibitor.
authors.affiliation: Syngenta Biotechnology, Inc, PO Box 12257, 3054 Cornwallis Road, Research Triangle Park, North Carolina 27709-2257, USA. Xianggan.Li@syngenta.com
authors.forename: Xianggan
authors.initials: X
authors.lastname: Li
authors.forename: David
authors.initials: D
authors.lastname: Nicholl
mesh_terms: D018556:Crops, Agricultural / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics; D015870:Gene Expression; D005818:Genetic Engineering; D006540:Herbicides / Q000494:pharmacology*; D009154:Mutation; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000037:antagonists & inhibitors* / Q000235:genetics; D030821:Plants, Genetically Modified / Q000187:drug effects* / Q000235:genetics; D050768:Protoporphyrinogen Oxidase
chemical_list: D006540:Herbicides; D044925:Oxidoreductases Acting on CH-CH Group Donors; D050768:Protoporphyrinogen Oxidase