title: Pyrrolidinohydroquinazolines--a novel class of CCR3 modulators.
abstract: A novel class of CCR3 modulators is described. Starting with lead compound 4a (K(i): 110 nM), which turned out to be an antagonist of eotaxin at the CCR3 receptor, further optimization led to compound 8b (K(i): 28 nM), which surprisingly proved to be an agonist.
authors.affiliation: Boehringer Ingelheim Pharma GmbH and Co. KG, Birkendorfer Strasse 65, D-88397 Biberach an der Riss, Germany. ralf.anderskewitz@bc.boehringer-ingelheim.com
authors.forename: Ralf
authors.initials: R
authors.lastname: Anderskewitz
authors.forename: Rolf
authors.initials: R
authors.lastname: Bauer
authors.forename: Gisela
authors.initials: G
authors.lastname: Bodenbach
authors.forename: Dirk
authors.initials: D
authors.lastname: Gester
authors.forename: Bernd
authors.initials: B
authors.lastname: Gramlich
authors.forename: Gerd
authors.initials: G
authors.lastname: Morschhäuser
authors.forename: Franz W
authors.initials: FW
authors.lastname: Birke
mesh_terms: D020013:Calcium Signaling / Q000187:drug effects; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000037:antagonists & inhibitors; D004804:Eosinophils / Q000187:drug effects; D006801:Humans; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000819:agonists / Q000037:antagonists & inhibitors / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: C515456:CCL11 protein, human; C515350:CCR3 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D011799:Quinazolines; D054397:Receptors, CCR3; D019707:Receptors, Chemokine