Effects of soy oil on murine salivary tumorigenesis.
Dietary fat influences dimethylbenzanthracene (DMBA)-induced tumorigenesis of several organs, including the salivary glands. There is not enough evidence to suggest that soy oil could also affect growth of salivary tumors. The main purpose of this work therefore was to study the effects of dietary soy oil on macroscopic parameters of chemically induced murine salivary gland tumors. Eighty BALB/c male mice were assigned to four groups: soy oil (SO), corn oil (CO, control), fish oil (FO) and olein (O). Two weeks later, tumors were induced by 9,10-dimethyl-1,2-benzanthracene (DMBA). At the 13th post-injection week, the animals were sacrificed. In vivo tumor diameter, gland volume (total resected mass), tumor volume (microscopically measured), tumor remission and tumor histopathology were analyzed. The initial in vivo tumor diameter, gland and tumor volume were significantly greater in soy oil than in fish oil group. 26.7% of animals on the soy oil diet showed tumor remission. Sarcomas were more often found in the SO group, carcinomas in FO and the mixed-type tumors both in SO and CO groups. This study shows that the soy oil treatment resulted in larger tumors, some of which later became undetectable. It is necessary to further investigate these divergent results.
Actis
Adriana B
AB
Facultad de Ciencias Médicas, Instituto de Biología Celular, Universidad Nacional de Córdoba, Casilla de Correo 220, 5000 Córdoba, Argentina. adractis@odo.unc.edu.ar
Cremonezzi
David C
DC
King
Irena B
IB
Joekes
Silvia
S
Eynard
Aldo R
AR
Valentich
Mirta A
MA
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002849:Chromatography, Gas; D005395:Fish Oils / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012468:Salivary Gland Neoplasms / Q000139:chemically induced / Q000178:diet therapy* / Q000473:pathology; D013024:Soybean Oil / Q000627:therapeutic use*; D013365:Submandibular Gland Neoplasms / Q000139:chemically induced / Q000178:diet therapy / Q000473:pathology
D005395:Fish Oils; D015127:9,10-Dimethyl-1,2-benzanthracene; D013024:Soybean Oil