Telomeres and telomerase: their mechanisms of action and the effects of altering their functions.
The molecular features of telomeres and telomerase are conserved among most eukaryotes. How telomerase and telomeres function and how they interact to promote the chromosome-stabilizing properties of telomeres are discussed here.
Blackburn
Elizabeth H
EH
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-2200, USA. telmor@itsa.ucsf.edu
D017209:Apoptosis; D002869:Chromosome Aberrations; D004268:DNA-Binding Proteins; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D019098:Telomerase / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D016615:Telomere / Q000235:genetics / Q000378:metabolism*
D004268:DNA-Binding Proteins; D019098:Telomerase