Morphofunctional characteristic of mast cells in BALB/c and C57Bl/6 mice during cold exposure.
Mast cells of the mesentery and subcutaneous tissue in BALB/c and C57Bl/6 mice were studied after single and repeated cold exposure (-20 degrees C, 3 min). Immediate adaptive reactions of mast cells in BALB/c and C57Bl/6 mice did not differ after single cold exposure and were manifested in increased degranulation. Repeated cold exposure of BALB/c mice was followed by an adaptive reaction, which included an increase in the count of mast cells in subcutaneous tissue and normalization of the degranulation index. In C57Bl/6 mice the count of mast cells in subcutaneous tissue decreased, while the degranulation index remained high. These changes reflect the disadaptive response of mast cells to repeated cold exposure.
Trunova
G V
GV
Laboratory for Immunomorphology of Inflammation, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow. morfolhum@mtu-net.ru
D000222:Adaptation, Physiological; D000818:Animals; D015550:Cell Degranulation / Q000502:physiology*; D003080:Cold Temperature; D008297:Male; D008407:Mast Cells / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000033:anatomy & histology*; D008810:Mice, Inbred C57BL / Q000033:anatomy & histology*