title: Propylene glycol is essential in the LCModel basis set for pediatric 1H-MRS.
abstract: Propylene glycol (PG) is an organic solvent used in a variety of parenterally injected pharmaceutical preparations. In this current study, we analyzed neonatal brains following routine MRS evaluation at 1.5 T, using the LCModel software, with and without the addition of PG to the analysis basis-set. We suggest including PG in the LCModel basis-set for neonatal brain H-MRS to improve the discrimination and quantification of lactate and inositol.
authors.affiliation: The Imaging Research Centre, Brain Body Institute, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
authors.forename: Wendy K
authors.initials: WK
authors.lastname: Oakden
authors.forename: Michael D
authors.initials: MD
authors.lastname: Noseworthy
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D001479:Basal Ganglia / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D018698:Glutamic Acid / Q000032:analysis; D005973:Glutamine / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007294:Inositol / Q000032:analysis; D019344:Lactic Acid / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011092:Polyethylene Glycols / Q000032:analysis*; D012189:Retrospective Studies; D012984:Software; D012997:Solvents / Q000032:analysis*; D013654:Taurine / Q000032:analysis
chemical_list: D012997:Solvents; D005973:Glutamine; D013654:Taurine; D001224:Aspartic Acid; D019344:Lactic Acid; D018698:Glutamic Acid; D011092:Polyethylene Glycols; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline