Photolithographic synthesis of cyclic peptide arrays using a differential deprotection strategy.
We report here a strategy for the photolithographic synthesis of diverse, spatially addressable arrays of cyclic peptides which employs a differential deprotection strategy for the combinatorial addition of side chains to a pre-fabricated cyclic core.
Li
Shuwei
S
Department of Internal Medicine, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA.
Marthandan
Nishanth
N
Bowerman
Dawn
D
Garner
Harold R
HR
Kodadek
Thomas
T
D015394:Molecular Structure; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D011327:Printing; D040081:Protein Array Analysis / Q000379:methods*; D013997:Time Factors; D014466:Ultraviolet Rays
D019151:Peptide Library; D010456:Peptides, Cyclic