Relation of aortic valve sclerosis to risk of coronary heart disease in African-Americans.
To assess the relation between aortic valve sclerosis (AVS) and subsequent occurrence of coronary heart disease (CHD) events, we analyzed echocardiographic data obtained from 2,279 middle-aged African-Americans enrolled in the Jackson Mississippi Atherosclerosis Risk in Communities study cohort who were free of known CHD at the time of the examination. Cox regression analyses demonstrated a hazard ratio of 3.8 for incident first myocardial infarction or fatal CHD after adjusted for multiple risk factors, including markers of inflammation. An amplification of CHD risk in the AVS subgroup with high levels of serum inflammatory markers (the highest quartile of fibrinogen and von Willebrand Factor levels) demonstrated greater than fivefold higher risk of CHD associated with AVS than risk in the lowest quartile.
Taylor
Herman A
HA
University of Mississippi Medical Center, Jackson, Mississippi, USA; Jackson State University, Jackson, Mississippi, USA. htaylor@medicine.umsmed.edu
Clark
Bobby L
BL
Garrison
Robert J
RJ
Andrew
Michael E
ME
Han
Hui
H
Fox
Ervin R
ER
Arnett
Donna K
DK
Samdarshi
Tandaw
T
Jones
Daniel W
DW
D001741:Black or African American / Q000706:statistics & numerical data*; D000368:Aged; D001021:Aortic Valve / Q000473:pathology; D016009:Chi-Square Distribution; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000208:ethnology*; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000208:ethnology*; D004452:Echocardiography; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008922:Mississippi / Q000453:epidemiology; D015995:Prevalence; D016016:Proportional Hazards Models; D012307:Risk Factors