Comparison of voltammetric detection assisted by multivariate curve resolution with amperometric detection in liquid chromatographic analysis of cysteine-containing compounds.
A voltammetric detection mode (VD) in conjunction with multivariate curve resolution with alternating least squares (MCR-ALS) method is applied to the analysis of cysteine-containing compounds and compared with a well established amperometric detection (AD) mode in a thin-layer dual Hg/Au cell. VD-MCR-ALS provides an increase in selectivity for cases where satisfactory separation of electroactive compounds is not allowed. However, concentrations needed for a good quantification in VD are higher than in AD due to much large contribution of background in VD.
González-García
Olga
O
Departament de Química Analítica, Universitat de Barcelona, E-08028 Barcelona, Spain.
Ariño
Cristina
C
Díaz-Cruz
José Manuel
JM
Esteban
Miquel
M
D003545:Cysteine / Q000032:analysis*; D004563:Electrochemistry / Q000379:methods*; D015999:Multivariate Analysis
D003545:Cysteine