Enantiomerical excess determination, purification and biological evaluation of (3S) and (3R) alpha,beta-butenolide analogues of isobenzofuranone.
The asymmetric synthesis of isobenzofurane analogues, new potential antiviral agents, is reported. High performance liquid chromatography (HPLC) was the technique chosen to separate the enantiomers. We describe this chiral separation and then determine the enantiomerical excess. The biological results of each tested enantiomer are given.
Lipka
Emmanuelle
E
Laboratoire de Chimie Analytique EA 1043, Université de Lille 2, BP 83-3, rue du Pr. Laguesse, 59006 Lille, France.
Vaccher
Marie-Pierre
MP
Vaccher
Claude
C
Len
Christophe
C
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D001572:Benzofurans