The developmental relationship between the deciduous dentition and the oral vestibule in human embryos.
In humans, there is no consensus about the developmental relationship between the deciduous dentition and the oral vestibule separating the teeth from the lips and cheeks. The classical concept assumes that two horseshoe-shaped epithelial structures exist: the dental lamina, giving rise to single tooth primordia, and the vestibular lamina running parallel and externally to it, giving rise to the oral vestibule. The aim of this study was to investigate the development of the dental and vestibular laminae in the upper jaw and to determine their developmental relationship in humans from embryonic week 6 to 9. Although a thickening of the vestibular epithelium was always present on serial histological sections, computer-aided three-dimensional reconstructions did not show any continuous vestibular lamina. Several discontinuous epithelial structures (bulges and ridges) occurred transiently at different stages of oral vestibule development. Along the mesiodistal axis, the dental and vestibular epithelia were regionalized in parallel: in the incisive, canine, and 1st and 2nd molar regions. The vestibular ridges fused with the dental lamina distally to the deciduous canine, 1st molar and 2nd molar. These interactions between the developing teeth and vestibular structures are reminiscent of the situation in some reptiles, where single teeth are paired one-to-one with single tooth glands.
Hovorakova
Maria
M
Department of Teratology, Institute of Experimental Medicine, Academy of Sciences CR, Videnska 1083, 142 20 Praha 4, Czech Republic.
Lesot
Herve
H
Peterka
Miroslav
M
Peterkova
Renata
R
D047108:Embryonic Development; D006801:Humans; D007568:Jaw / Q000196:embryology; D009055:Mouth / Q000196:embryology*; D014094:Tooth, Deciduous / Q000196:embryology*