Effect of dehydroepiandrosterone on radioligand binding of [3H]-testosterone by androgen receptors in rat hypothalamus.
Intramuscular injections of dehydroepiandrosterone in a dose of 0.7 mg/kg for 10 days significantly increased nuclear and cytoplasmic fractions of androgen receptors in the preoptic/anterior hypothalamic area. Presumably, the effect of the neurosteroid is mediated by 5 alpha-reductase transformation of dehydroepiandrosterone into 5 alpha-dehydroepiandrosterone, which initiates the synthesis of androgen receptors.
Bairamov
A A
AA
Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg. alekber@mail.ru
Sapronov
N S
NS
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D042944:Cholestenone 5 alpha-Reductase / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000378:metabolism / Q000494:pharmacology*; D012739:Gonadal Steroid Hormones / Q000172:deficiency; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism*; D007032:Hypothalamus, Anterior / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009919:Orchiectomy; D011301:Preoptic Area / Q000187:drug effects / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011944:Receptors, Androgen / Q000187:drug effects* / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D012739:Gonadal Steroid Hormones; D011944:Receptors, Androgen; D013739:Testosterone; D003687:Dehydroepiandrosterone; D042944:Cholestenone 5 alpha-Reductase