Drug-induced hypersensitivity syndrome in a premature infant.
Fever, skin reactions, and limb edema because of drug-induced hypersensitivity have been reported in children because of various drugs, mainly aromatic antiepileptic drugs such as phenytoin, phenobarbital, carbamazepin, and primidone. The skin reactions differ in severity and range from mild maculopapular erythema to exfoliative dermatitis. They have been described in older children but have not been reported in newborn infants. We report a premature newborn infant who developed fever, skin reactions, and edema because of phenytoin while receiving anticonvulsant therapy.
Yigit
Sule
S
Department of Neonatology, Hacettepe University, Ihsan Dogramici Children's Hospital, 06100 Ankara, Turkey. suleyigit@turk.net
Korkmaz
Ayse
A
Sekerel
Bulent
B
D018926:Anti-Allergic Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000927:Anticonvulsants / Q000009:adverse effects*; D003907:Dexamethasone / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology* / Q000628:therapy; D004837:Epinephrine / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*
D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D010672:Phenytoin; D003907:Dexamethasone; D004837:Epinephrine