title: Kinesin: world's tiniest biped.
abstract: Kinesin, an essential motor protein that moves intracellular cargo along microtubules, walks like a person. When we walk, our feet exchange roles with each step, one moving and one remaining stationary. The moving foot travels twice as far as our torso during a single step, and our body alternates between two configurations (left vs. right leg leading). Recent work shows that kinesin shares all three of these hallmarks of bipedal walking. The challenge now is to determine how the gait of this lilliputian biped is coordinated.
authors.affiliation: Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195-7290, USA. casbury@u.washington.edu
authors.forename: Charles L
authors.initials: CL
authors.lastname: Asbury
mesh_terms: D000244:Adenosine Diphosphate / Q000737:chemistry; D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D006801:Humans; D016547:Kinesins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D008853:Microscopy; D008954:Models, Biological; D009068:Movement; D010455:Peptides / Q000737:chemistry; D011487:Protein Conformation
chemical_list: D010455:Peptides; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D016547:Kinesins