[Arterial hypertension in adolescents with different physical constitution including those with signs of metabolic syndrome].
OBJECTIVE
Detection of clinico-paraclinical features of arterial hypertension (AH) in adolescents with different physical constitution including signs of metabolic syndrome (MS).


METHODS
Blood levels of uric acid, cholesterol, triglycerides (TG), high and low density lipoproteins were examined and glucose tolerance test was made in 108 adolescents with arterial hypertension (AH) and different physical constitution (normal, with overweight and obese). Waist and hip distribution of fat was assessed. The control group consisted of 108 healthy adolescents.


RESULTS
Most of the hypertensive children had hyperuricemia (HU), some of the patients combined HU with changes in glycemic profile of blood. The above abnormalities were especially evident in patients with MS who were characterized by abdominal obesity, higher blood pressure, subnormal high density lipoproteins, higher triglycerides and total cholesterol in blood, more severe HU and defects in glycemic profile of blood.


CONCLUSIONS
MS in adolescents may be of genetic origin as well as constitutional HU and insulin resistance may be mutually dependent signs combination of which with other factors presents the whole spectrum of clinical and paraclinical manifestations of MS. Detection of HU and insulin resistance with their correction in a preclinical disease stage (in children and adolescents) may represent a new line in prevention of AH and MS in adults.
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D000293:Adolescent; D015992:Body Mass Index; D001837:Body Weights and Measures; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D033461:Hyperuricemia / Q000150:complications / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology; D008074:Lipoproteins / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
D008074:Lipoproteins; D014280:Triglycerides; D014527:Uric Acid; D002784:Cholesterol