title: Twenty-two year experience with the omniscience prosthetic heart valve.
abstract: This study was designed to evaluate the long-term clinical results of the Omniscience tilting disc valve. Omniscience valves were implanted in 51 patients (mean age, 50 +/- 10 years); 18 had aortic valve, 24 had mitral valve, and 9 had both aortic and mitral valve replacements. Oral warfarin potassium and dipyridamole were prescribed as our anticoagulant therapy. Preoperatively, 42 patients were in New York Heart Association class III or IV, and 23 of 25 surviving patients were in class I or II after operation. There were 2 (3.9%) early deaths and 23 late deaths (3.5 +/- 0.7% per patient-year). Cardiac related mortality including congestive heart failure, sudden death, and thromboembolism, and hemorrhagic complications were seen in 16 patients. Overall survival at 10, 15, and 20 years was 77 +/- 6%, 62 +/- 7%, and 46 +/- 7%, respectively. Thromboembolic complications were seen in 5 patients, for a rate of 0.8 +/- 0.3% per patient-year; similarly, hemorrhagic complications were also seen in 5 patients. Nonstructural prosthetic valve dysfunction was seen in 4 patients, for a rate of 0.6 +/- 0.3% per patient-year, and sudden death was seen in 2, a rate of 0.3 +/- 0.2% per patient-year. The Omniscience prosthesis demonstrated excellent postoperative clinical status with low rates of valve related complications.
authors.affiliation: Division of Cardiovascular Surgery, Jichi Medical School, Tochigi, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Misawa
authors.forename: Masanobu
authors.initials: M
authors.lastname: Taguchi
authors.forename: Kei
authors.initials: K
authors.lastname: Aizawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Sakano
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kaminishi
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Oki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Konishi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Saito
authors.forename: Morito
authors.initials: M
authors.lastname: Kato
mesh_terms: D000328:Adult; D001021:Aortic Valve; D002318:Cardiovascular Diseases / Q000401:mortality; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery*; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D011475:Prosthesis Failure; D019919:Prosthesis Implantation; D012189:Retrospective Studies; D016019:Survival Analysis; D013923:Thromboembolism / Q000209:etiology