Differential pulse voltammetric determination of carvedilol in tablets dosage form using glassy carbon electrode.
The electrochemical oxidation of antihypertensive drug carvedilol has been studied in pH range 2.0-11.0 at a glassy carbon electrode by cyclic and differential pulse voltammetry. Two oxidation processes were produced in different supporting electrolyte media. Both oxidation processes were irreversible and diffusion-controlled. The first oxidation process was chosen for the analysis of carvedilol. A very resolved voltammetric peak was obtained in Britton-Robinson buffer at pH 8.0 using differential pulse mode. The linear response was obtained in the range of 0.25-10.00 microg ml(-1). The limit of detection was found to be 0.10 microg ml(-1). The developed method was used for the determination of carvedilol in tablet dosage form.
Radi
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Department of Chemistry, Faculty of Science, Mansoura University, 34517 Dumyat, Egypt. abdradi@yahoo.com
Elmogy
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D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D002227:Carbazoles / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D000077261:Carvedilol; D004304:Dosage Forms; D004563:Electrochemistry; D004566:Electrodes; D005898:Glass; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D011412:Propanolamines / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D013607:Tablets
D000959:Antihypertensive Agents; D002227:Carbazoles; D004304:Dosage Forms; D007202:Indicators and Reagents; D011412:Propanolamines; D013607:Tablets; D000077261:Carvedilol