title: Specific interleukin-1 gene polymorphisms in Turkish patients with Behçet's disease.
abstract: Genetic factors that predispose individuals to Behçet's disease (BD) are considered to play important roles in the development of the disease. The pro-inflammatory cytokine interleukin-1 (IL-1) has been implicated in the pathogenesis of BD. Our aim was to determine a possible association of specific polymorphisms of IL-1alpha, IL-1beta, and IL-1 receptor antagonist genes with susceptibility for BD. We genotyped 72 patients with BD and 163 healthy controls for IL-1alpha-889, IL-1beta-511, and +3953 (nt5887) single-nucleotide polymorphisms besides IL-1 receptor antagonist variable number of tandem repeat polymorphism (for five different alleles). Comparison of the IL-1beta+3953 T allele and TT genotype frequencies showed a significant difference between patients with BD and controls (54.2 vs. 40.5%, OR = 1.74, P = 0.024, and 40.3 vs. 19.6%, OR = 2.76, P = 0.009, respectively). However, no difference was observed in the genotype or allele frequencies of IL-1alpha-889, IL-1beta-511, and IL-1 receptor antagonist between the patients with BD and the controls. Our results indicate that susceptibility to BD is increased in individuals carrying the IL-1beta+3953 T allele and TT genotype.
authors.affiliation: Department of Pediatric Immunology, Akdeniz University School of Medicine, Antalya, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Coskun
authors.forename: Ali
authors.initials: A
authors.lastname: Bacanli
authors.forename: Nilgun
authors.initials: N
authors.lastname: Sallakci
authors.forename: Erkan
authors.initials: E
authors.lastname: Alpsoy
authors.forename: Ugur
authors.initials: U
authors.lastname: Yavuzer
authors.forename: Olcay
authors.initials: O
authors.lastname: Yegin
mesh_terms: D000328:Adult; D000483:Alleles; D001528:Behcet Syndrome / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D014421:Turkey
chemical_list: D007375:Interleukin-1