Recovery of contractile function of cryodamaged rat myocardium after transplantation of fetal cardiomyocytes and predifferentiated bone marrow stromal stem cells.
The effect of cell transplantation into cryodamaged rat myocardium was studied on isolated hearts by increasing functional load to the left ventricle. Transplantation of allogeneic fetal cardiomyocytes improved the function of the left ventricle under conditions of considerably increased preload. Transplantation of autologous mesenchymal stem cells repaired left-ventricular function under conditions of increased pre- and afterload.
Onishchenko
N A
NA
Laboratory of Stem Cell Biotechnology, Institute of Transplantation and Artificial Organs, Ministry of Health of the Russian Federation, Moscow. biolab@online.ru
Potapov
I V
IV
Bashkina
L V
LV
Krasheninnikov
M E
ME
Zaidenov
V A
VA
Avramov
P V
PV
D000818:Animals; D016332:Fetal Tissue Transplantation; D005615:Freezing; D006335:Heart Injuries / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D032383:Myocytes, Cardiac / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar