Search for potent modulators of cytokine production by macrophages.
We compared the effects of Tamerit, Polyoxidony, and Licopid on spontaneous and lipopolysaccharide-stimulated production of interleukin-1 and tumor necrosis factor by mouse peritoneal macrophages in vitro. The test preparations were equally potent in stimulating nonactivated cells. Licopid produced a costimulatory effect on macrophages primed with endotoxin. Tamerit in different doses suppressed cytokine production by cells. Polyoxidony in low doses activated, but in high doses suppressed this process.
Nikitin
A A
AA
Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia.
Abidov
M T
MT
Kovalevskaya
E O
EO
Kalyuzhin
O V
OV
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D007375:Interleukin-1 / Q000096:biosynthesis / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D010793:Phthalazines / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011095:Polyethylenes / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D000276:Adjuvants, Immunologic; D016207:Cytokines; D007375:Interleukin-1; D010793:Phthalazines; D010879:Piperazines; D011095:Polyethylenes; D014409:Tumor Necrosis Factor-alpha; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C017654:polyethylene piperazine N-oxide