Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetes.
Insulin peptide B:9-23 (amino acids 9 to 23 of the B chain) can induce immune targeting of insulin and islets in normal Balb/c mice. The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin.
Devendra
Devasenan
D
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
Paronen
Johanna
J
Liu
Edwin
E
Moriyama
Hiroaki
H
Taylor
Robert
R
Miao
Dongmei
D
Yu
Liping
L
Eisenbarth
George
G
D000284:Administration, Oral; D000818:Animals; D015703:Antigens, CD; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D004195:Disease Models, Animal; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use*; D007330:Insulin Antibodies / Q000097:blood*; D039001:Integrin alpha Chains; D051379:Mice; D008807:Mice, Inbred BALB C; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000627:therapeutic use*
D015703:Antigens, CD; D007328:Insulin; D007330:Insulin Antibodies; D039001:Integrin alpha Chains; D010446:Peptide Fragments; C091367:alpha E integrins; C041903:insulin B (9-30)