Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships.
1. The GABAergic neurotransmission has been implicated in the modulation of many neural networks in forebrain, midbrain and hindbrain, as well as, in several neurological disorders. 2. The complete comprehension of GABA system neurochemical properties and the search for approaches in identifying new targets for the treatment of neural diseases related to GABAergic pathway are of the extreme relevance. 3. The present review will be focused on the pharmacology and biochemistry of the GABA metabolism, GABA receptors and transporters. In addition, the pathological and psychobiological implications related to GABAergic neurotransmission will be considered.
Beleboni
Renê Oliveira
RO
Departament of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Carolino
Ruither Oliveira Gomes
RO
Pizzo
Andrea Baldocchi
AB
Castellan-Baldan
Lissandra
L
Coutinho-Netto
Joaquim
J
dos Santos
Wagner Ferreira
WF
Coimbra
Norberto Cysne
NC
D000818:Animals; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D050485:GABA Plasma Membrane Transport Proteins; D006801:Humans; D026901:Membrane Transport Proteins / Q000502:physiology*; D018079:Receptors, GABA / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D050485:GABA Plasma Membrane Transport Proteins; D026901:Membrane Transport Proteins; D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid