Mutagenesis of a novel gene in the prcA-prtP protease locus affects expression of Treponema denticola membrane complexes.
A novel gene was identified in the Treponema denticola prcA-prtP protease operon. Strains with mutations in either the prcA-prtP or the msp region showed altered expression of a product(s) of the other locus. Together, these results provide information on the assembly of outer membrane complexes involved in T. denticola interaction with host cells and tissue.
Bian
Xue-Lin
XL
Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA.
Wang
Hong-Tao
HT
Ning
Yu
Y
Lee
Si Young
SY
Fenno
J Christopher
JC
D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002918:Chymotrypsin / Q000235:genetics* / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D010447:Peptide Hydrolases; D018272:Porins / Q000235:genetics* / Q000378:metabolism; D013381:Subtilisins / Q000235:genetics* / Q000378:metabolism; D048373:Treponema denticola / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism
D001426:Bacterial Proteins; D008565:Membrane Proteins; D018272:Porins; C102527:PrcA protein, bacteria; C099361:major outer sheath protein, Treponema; D010447:Peptide Hydrolases; D013381:Subtilisins; C102570:dentilisin; D002918:Chymotrypsin