title: High-throughput target discovery using cell-based genetics.
abstract: High-throughput target discovery requires robust disease models and the ability to rapidly survey the genome for function. In the post-genomics era, there has been a strong emphasis placed upon "gene-to-function" approaches that take advantage of the large amount of gene sequence information now available. Here, we advocate a return to "function-to-gene" approaches as a first step in target discovery (and validation), followed by hypothesis-driven research to validate new targets identified by their activity in cell-based disease models.
authors.affiliation: Athersys Inc., 3201 Carnegie Ave., Cleveland, OH 44115, USA.
authors.forename: P David
authors.initials: PD
authors.lastname: Jackson
authors.forename: John J
authors.initials: JJ
authors.lastname: Harrington
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D015195:Drug Design; D015698:Genomic Library; D023281:Genomics / Q000639:trends*; D006801:Humans; D008957:Models, Genetic; D040901:Proteomics