title: No influence of the P-glycoprotein polymorphisms MDR1 G2677T/A and C3435T on the virological and immunological response in treatment naïve HIV-positive patients.
abstract: BACKGROUND
  In a retrospective study of HIV-infected patients, we investigated the influence of the MDR1 genotype (G2677T/A and C3435T) on the virological and immunological response of treatment naive patients.
  
  
  METHODS
  The MDR1 genotype was analysed from 72 patients in whom antiretroviral therapy was initiated between 1998 and 2004. Data were obtained at week 4, 12, 24 and 48 and were analysed by the Kruskal-Wallis test.
  
  
  RESULTS
  During the first 48 weeks of antiretroviral therapy, there were no significant differences in the virological and immunological response with respect to the MDR1 2677 and 3435 genotypes and the 2677/3435 haplotype.
  
  
  CONCLUSIONS
  In view of different results from several studies concerning the influence of MDR1 polymorphisms on the immunological and virological response to antiretroviral therapy, further studies with larger patient groups and longer follow-up are necessary in order to resolve conflicting issues.
authors.affiliation: Medical Policlinic, Division of Infectious Diseases, University of Würzburg, Josef-Schneider-Str, 2, 97080 Würzburg, Germany. Winzer_R@klinik.uni-wuerzburg.de
authors.forename: Ralf
authors.initials: R
authors.lastname: Winzer
authors.forename: Peter
authors.initials: P
authors.lastname: Langmann
authors.forename: Michael
authors.initials: M
authors.lastname: Zilly
authors.forename: Franz
authors.initials: F
authors.lastname: Tollmann
authors.forename: Jörg
authors.initials: J
authors.lastname: Schubert
authors.forename: Hartwig
authors.initials: H
authors.lastname: Klinker
authors.forename: Benedikt
authors.initials: B
authors.lastname: Weissbrich
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D005260:Female; D019450:Genes, MDR; D005838:Genotype; D006679:HIV Seropositivity / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents