pH-Switchable strand orientation in peptide assemblies.
[structure: see text] The design of antiparallel coiled-coil heterotrimers with singly mismatched electrostatic interfaces is reported. The new complexes exhibit expected properties for well-formed coiled-coils and have stabilities comparable to those of parallel analogues. The mismatched interface facilitates switching from a parallel to antiparallel complex by pH-triggered strand exchange.
Schnarr
Nathan A
NA
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Kennan
Alan J
AJ
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D004220:Disulfides / Q000737:chemistry; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D011487:Protein Conformation
D004220:Disulfides; D010455:Peptides