title: [Prevention of acute exacerbation of interstitial pneumonia in the patients operated for lung cancer].
abstract: Eight patients with interstitial pneumonia (IP) underwent pulmonary surgery for lung cancer. The first patient died due to postoperative exacerbation, but the subsequent 7 patients had good postoperative course without exacerbation by the following careful management. 1) Avoidance of administration of high concentration of oxygen keeping the PO2 about 100 mmHg during the operation. 2) Short-term administration of low-dose steroid before the operation. 3) Administration of erythromycin, tocopherol acetate, and inhalation of N-acetylcysteine before and after the operation. 4) Long-term drainage of the postoperative thoracic discharge to release the local cytokines. These treatments inhibit secretion of the inflammatory cytokines which influence exacerbation of IP.
authors.affiliation: Department of Thoracic Surgery, Sapporo City General Hospital, Sapporo, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tanaka
authors.forename: R
authors.initials: R
authors.lastname: Harada
authors.forename: S
authors.initials: S
authors.lastname: Muraki
authors.forename: A
authors.initials: A
authors.lastname: Yamauchi
authors.forename: H
authors.initials: H
authors.lastname: Osawa
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000473:pathology*; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D011013:Pneumonectomy / Q000009:adverse effects; D011183:Postoperative Complications / Q000517:prevention & control*