Pregnancy outcome in recurrent aborters is not influenced by Chlamydia IgA and/or G.
OBJECTIVE
It is unclear whether chlamydia infection influences the miscarriage rate and immunological factors in patients with recurrent miscarriage.


METHODS
Chlamydia DNA, IgA and IgG to Chlamydia trachomatis, natural killer cell activity, complement 3 (C3), C4, hemolytic complement, antinuclear antibodies, antiphospholipid antibodies, prolactin, activated partial thromboplastin time, prothrombin time and fibrinogen were examined in 504 patients with a history of two or more consecutive first-trimester miscarriages. Subsequent pregnancy outcomes were compared between cases with and without antibodies to C. trachomatis.


RESULTS
Totals of 10 of 30 and 48 of 201 patients receiving no medication miscarried subsequently with and without chlamydia infection. Chlamydia IgA and/or IgG were associated with a high level of C3 but not other immunological and coagulatory parameters.


CONCLUSIONS
Antibodies to C. trachomatis do not influence subsequent pregnancy outcome in patients with a history of recurrent miscarriage.
Sugiura-Ogasawara
Mayumi
M
Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan. og.mym@med.nagoya-cu.ac.jp
Ozaki
Yasuhiko
Y
Nakanishi
Tamao
T
Kumamoto
Yoshiaki
Y
Suzumori
Kaoru
K
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D002690:Chlamydia Infections / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D011247:Pregnancy; D011256:Pregnancy Outcome
D007070:Immunoglobulin A; D007074:Immunoglobulin G