Selective generation of gut-tropic T cells in gut-associated lymphoid tissues: requirement for GALT dendritic cells and adjuvant.
To gain entry into peripheral tissues, effector T lymphocytes express specific combinations of adhesion molecules and chemokine receptors. Expression of these are induced during activation in regional secondary lymphoid organs. Herein, we describe a role for GALT DCs in the generation of CCR9(+) alpha(4)beta(7)(+) gut tropic lymphocytes.
Svensson
Marcus
M
Immunology Section, Lund University, BMC I-13, S-22184 Lund, Sweden. Marcus.Svensson@immuno.lu.se
Johansson-Lindbom
Bengt
B
Wurbel
Marc-André
MA
Malissen
Bernard
B
Márquez
Gabriel
G
Agace
William
W
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D018925:Chemokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal; D007249:Inflammation / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology; D016201:Receptors, Lymphocyte Homing / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D018925:Chemokines; D016201:Receptors, Lymphocyte Homing