title: Activating effect of Tanacetum vulgare L. pectin polysaccharide on ionic channels of neuronal membrane.
abstract: The membranotropic effects of TVF tanacetan pectin polysaccharide derived from Tanacetum vulgare L. was studied by the voltage-clamp method on isolated neurons of Lymnaea stagnalis mollusk. TVF in concentrations of 0.1-10.0 microg/ml nonselectively activated the outward potassium and total inward (sodium and calcium) ionic currents (slightly dose-dependently and reversibly increased their amplitude by 5-10%) and decreased nonspecific leakage current.
authors.affiliation: Institute of Physiology, Komi Research Center, Ural Division of Russian Academy of Sciences, Syktyvkar.
authors.forename: A I
authors.initials: AI
authors.lastname: Vislobokov
authors.forename: V I
authors.initials: VI
authors.lastname: Prosheva
authors.forename: A Ya
authors.initials: AY
authors.lastname: Polle
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism*; D007700:Kinetics; D008195:Lymnaea; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism*; D010368:Pectins / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D031203:Tanacetum
chemical_list: D007473:Ion Channels; D010368:Pectins; D011188:Potassium