title: Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: a point-counterpoint discussion.
abstract: Patients with claudication have a marked impairment in exercise performance. Several factors contribute to this limitation, including reductions in large vessel blood flow and oxygen delivery as well as metabolic abnormalities in skeletal muscle. The relative contribution of these factors and their role in the pathophysiology of the exercise limitation is discussed using a point-counterpoint approach. Future directions for research conclude the discussion.
authors.affiliation: Center for Clinical Pharmacology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: Eric P
authors.initials: EP
authors.lastname: Brass
authors.forename: William R
authors.initials: WR
authors.lastname: Hiatt
authors.forename: Simon
authors.initials: S
authors.lastname: Green
mesh_terms: D017079:Exercise Tolerance; D006801:Humans; D007383:Intermittent Claudication / Q000378:metabolism / Q000503:physiopathology; D007866:Leg / Q000098:blood supply / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000098:blood supply / Q000378:metabolism* / Q000503:physiopathology*; D010101:Oxygen Consumption; D016491:Peripheral Vascular Diseases / Q000378:metabolism* / Q000503:physiopathology*; D012039:Regional Blood Flow