title: Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates.
abstract: Enhancement of the relaxivities of Gd-based MRI contrast agents is achieved by placing the metal ion at the barycentre of the molecular complex in order to improve motional coupling.
authors.affiliation: Department of Chemistry, University of Durham, South Road, Durham, UK DH1 3LE.
authors.forename: David A
authors.initials: DA
authors.lastname: Fulton
authors.forename: Mark
authors.initials: M
authors.lastname: O'Halloran
authors.forename: David
authors.initials: D
authors.lastname: Parker
authors.forename: Kanthi
authors.initials: K
authors.lastname: Senanayake
authors.forename: Mauro
authors.initials: M
authors.lastname: Botta
authors.forename: Silvio
authors.initials: S
authors.lastname: Aime
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D015394:Molecular Structure; D008970:Molecular Weight; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D003287:Contrast Media; D050091:Dendrimers; D009942:Organometallic Compounds; D005682:Gadolinium