Serum KL-6 and surfactant proteins A and D in pediatric interstitial lung disease.
OBJECTIVE
To determine if serum KL-6, surfactant protein A (SP-A), and surfactant protein D (SP-D) levels are elevated in pediatric interstitial lung disease (ILD) and associated with pulmonary function and disease severity score.


METHODS
Serum KL-6, SP-A, and SP-D levels were measured by enzyme-linked immunosorbent assay in 10 children with ILD and in 10 healthy volunteers. In the ILD group, FEV1 percentage of predicted, FVC percentage of predicted, and ILD disease severity score were measured and correlated with serum KL-6, SP-A, and SP-D levels.


RESULTS
For the ILD and control groups, respectively, mean serum KL-6 was 4,523 U/mL and 206 U/mL (p = 0.007), mean serum SP-A was 133 ng/mL and 21 ng/mL (p = 0.003), and mean serum SP-D was 304 ng/mL and 75 ng/mL (p = 0.004). There was an inverse relationship between SP-A and FVC (p = 0.05), and between SP-D and FEV1 (p = 0.05). There was a direct relationship between SP-D and ILD score (p = 0.05).


CONCLUSIONS
Serum KL-6, SP-D and SP-D levels are elevated in children with ILD. SP-A and SP-D levels appear to correlate with some measures of disease severity.
Al-Salmi
Qasem A
QA
Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Walter
Joseph N
JN
Colasurdo
Giuseppe N
GN
Sockrider
Marianna M
MM
Smith
E O'brian
EO
Takahashi
Hiroki
H
Fan
Leland L
LL
D000293:Adolescent; D000941:Antigens / Q000097:blood*; D000951:Antigens, Neoplasm; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005541:Forced Expiratory Volume; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000503:physiopathology; D018396:Mucin-1; D009077:Mucins; D037662:Pulmonary Surfactant-Associated Protein A / Q000097:blood*; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D014797:Vital Capacity
D000941:Antigens; D000951:Antigens, Neoplasm; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D