title: Insights into the mechanism of oral tolerance derived from the study of models of mucosal inflammation.
abstract: Murine models of mucosal inflammation are frequently due to the inability of the mouse to mount a regulatory T cell response. To the extent that such responses arise from oral tolerance mechanisms, these models provide a unique way of studying oral tolerance. In this paper we focus on the regulatory cells generated in two of the most well-studied of such models, the cell-transfer model and the TNBS-colitis model. Our analysis leads to the view that regulatory cells generated by the oral tolerance seen in mucosal inflammation are, at least in part, cells that recognize self-antigens or antigens in the mucosal microflora whose effector function relies on the expression of TGF-beta.
authors.affiliation: The Mucosal Immunity Section, Laboratory of Host Defense, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. wstrober@niaid.nih.gov
authors.forename: Warren
authors.initials: W
authors.lastname: Strober
authors.forename: Ivan
authors.initials: I
authors.lastname: Fuss
authors.forename: Monica
authors.initials: M
authors.lastname: Boirivant
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kitani
mesh_terms: D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D007108:Immune Tolerance; D018928:Immunity, Mucosal; D007249:Inflammation / Q000276:immunology*; D051379:Mice; D009061:Mouth Mucosa / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014302:Trinitrobenzenesulfonic Acid
chemical_list: D016207:Cytokines; D014302:Trinitrobenzenesulfonic Acid