title: Evaluation of oral therapy on Mansonial Schistosomiasis using single dose of Balanites aegyptiaca fruits and praziquantel.
abstract: The efficacy of Balanites aegyptiaca fruit mesocarp was compared with praziquantel in mice infected with Sudanese strain of Schistosoma mansoni. Infected mice were given a single dose of 200 mg/kg body weight of B. aegyptiaca fruit mesocarp and 200 mg/kg b.w. of praziquantel after 6 weeks from the onset of the infection. A significant reduction was observed in EPG (egg count per gram of faeces), eggs burden in tissues and recovery of adult worms (P<0.05) for both the plant and the drug-treated animals.
authors.affiliation: Medicinal and Aromatic Plants Research Institute, National Centre for Research, P.O. Box 2404, Khartoum, Sudan. wasyko2002@yahoo.com
authors.forename: W S
authors.initials: WS
authors.lastname: Koko
authors.forename: H S
authors.initials: HS
authors.lastname: Abdalla
authors.forename: M
authors.initials: M
authors.lastname: Galal
authors.forename: H S
authors.initials: HS
authors.lastname: Khalid
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D032430:Balanites; D004359:Drug Therapy, Combination; D005243:Feces / Q000469:parasitology; D005260:Female; D005638:Fruit; D008297:Male; D051379:Mice; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011223:Praziquantel / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D012550:Schistosoma mansoni / Q000187:drug effects*; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000469:parasitology; D012908:Snails / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D010936:Plant Extracts; D011223:Praziquantel