title: A bunch of fun-guys: the whole-genome view of yeast evolution.
abstract: The resolution of the complete sequences of several hemiascomycete genomes provides new insights into the ways that yeast genomes change in size and in gene contents. These genomes provide evidence of whole-genome duplication occurring before the divergence of Saccharomyces cerevisiae and Candida glabrata, followed by massive gene loss that restored diploidy. The pattern of genome evolution in yeast differs from that in bacteria apparently as a result of stronger selective constraints on bacterial chromosomes.
authors.affiliation: Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 87521, USA. hochman@email.arizona.edu
authors.forename: Howard
authors.initials: H
authors.lastname: Ochman
authors.forename: Vincent
authors.initials: V
authors.lastname: Daubin
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Lerat
mesh_terms: D041221:Candida glabrata / Q000145:classification / Q000235:genetics; D019143:Evolution, Molecular; D020440:Gene Duplication; D016681:Genome, Fungal; D010802:Phylogeny; D012441:Saccharomyces cerevisiae / Q000145:classification / Q000235:genetics*