Letrozole significantly improves growth potential in a pubertal boy with growth hormone deficiency.
Clinical experience with using an aromatase inhibitor to suppress estrogen production during puberty for improvement of growth potential in adolescents with short stature is limited. This report documents treatment of such a patient with a combination of growth hormone and letrozole, a third-generation aromatase inhibitor. Our case demonstrates a favorable outcome on a short-term basis.
Zhou
Ping
P
Division of Pediatric Endocrinology, New York University School of Medicine, New York, New York 10016, USA.
Shah
Bina
B
Prasad
Kris
K
David
Raphael
R
D000293:Adolescent; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D004359:Drug Therapy, Combination; D006130:Growth Disorders / Q000097:blood / Q000188:drug therapy*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D000077289:Letrozole; D008055:Lipids / Q000097:blood; D008297:Male; D009570:Nitriles / Q000627:therapeutic use*; D013739:Testosterone / Q000097:blood; D014230:Triazoles / Q000627:therapeutic use*
D047072:Aromatase Inhibitors; D015415:Biomarkers; D008055:Lipids; D009570:Nitriles; D014230:Triazoles; D019382:Human Growth Hormone; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D000077289:Letrozole