Three new taxane diterpenoids from Taxus sumatrana.
Phytochemical investigation of taxane diterpenoidal content of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of three new taxoid compounds, tasumatrols E (1), F (2), and G (3) together with 13 known taxanes (5-16). The structures of these taxanes as well as their derivatives were established on the basis of spectroscopic analyses, especially 1D and 2D NMR. Compounds 1, 2, 12, and 16 exhibited significant cytotoxicity against human A-498, NCI-H226, A549, and PC-3 tumor cells.
Shen
Ya-Ching
YC
Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan 80424, Republic of China. ycshen@mail.nsysu.edu.tw
Cheng
Kuen-Ching
KC
Lin
Yun-Chi
YC
Cheng
Yuan-Bin
YB
Khalil
Ashraf Taha
AT
Guh
Jih-Hwa
JH
Chien
Ching-Te
CT
Teng
Che-Ming
CM
Chang
Yao-To
YT
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan; D043823:Taxoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020946:Taxus / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; C497958:tasumatrol E; C497959:tasumatrol F; C497960:tasumatrol G