title: Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell line.
abstract: The authors have developed a class of potent inhibitors against the phosphate specific prolyl isomerase hPin1, which induced apoptosis in transformed cell lines.
authors.affiliation: Molecular and Structural Biophysics, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Str. 11, D-44227 Dortmund, Germany.
authors.forename: Elena
authors.initials: E
authors.lastname: Bayer
authors.forename: Michael
authors.initials: M
authors.lastname: Thutewohl
authors.forename: Claudia
authors.initials: C
authors.lastname: Christner
authors.forename: Thomas
authors.initials: T
authors.lastname: Tradler
authors.forename: Frank
authors.initials: F
authors.lastname: Osterkamp
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
authors.forename: Peter
authors.initials: P
authors.lastname: Bayer
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000037:antagonists & inhibitors*; D018631:ras Proteins / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D018631:ras Proteins; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase