Resistance to dual nucleoside reverse-transcriptase inhibitors in children infected with HIV clade A/E.
The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothymidine was universal.
Lolekha
Rangsima
R
Queen Sirikit National Institute of Child Health.
Sirivichayakul
Sunee
S
Siangphoe
Umaporn
U
Pancharoen
Chitsanu
C
Kaewchana
Suchada
S
Apateerapong
Wichitra
W
Mahanontharit
Apicha
A
Chotpitayasunondh
Tawee
T
Ruxrungtham
Kiat
K
Phanuphak
Praphan
P
Ananworanich
Jintanat
J
D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D024921:Drug Resistance, Multiple, Viral / Q000187:drug effects; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D006801:Humans; D008297:Male; D009154:Mutation; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use
D018894:Reverse Transcriptase Inhibitors