The association of depression with disease course in multiple sclerosis.
The relative frequency of depression in people with primary progressive multiple sclerosis (PPMS) (30 patients) compared with those with a history of relapse (106 patients) was determined. Three participants in the progressive group and 28 in the relapsing group had a lifetime history of major depression. The lifetime morbidity ratio for major depression in relapsing patients was 2.64 compared with that of PPMS.
Zabad
Rana K
RK
Department of Clinical Neurosciences, University of Calgary, Alberta, Canada.
Patten
Scott B
SB
Metz
Luanne M
LM
D000328:Adult; D003430:Cross-Sectional Studies; D003863:Depression / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000523:psychology*; D020528:Multiple Sclerosis, Chronic Progressive; D020529:Multiple Sclerosis, Relapsing-Remitting; D011788:Quality of Life; D011795:Surveys and Questionnaires