Ergosterol peroxide, an apoptosis-inducing component isolated from Sarcodon aspratus (Berk.) S. Ito.
Among the lipophilic extracts of seven traditional edible mushrooms, the acetone extract of Sarcodon aspratus markedly inhibited the growth of HL60 human leukemia cells and induced apoptosis after 24 h incubation. The major active component was identified as ergosterol peroxide by NMR and ESI-MS analysis. Ergosterol peroxide completely inhibited growth and induced apoptosis of HL60 cells at a concentration of 25 microM.
Takei
Toshiyuki
T
Fukushima Prefectural Forestry Research Centre, Fukushima, Japan.
Yoshida
Mitsuru
M
Ohnishi-Kameyama
Mayumi
M
Kobori
Masuko
M
D017209:Apoptosis / Q000187:drug effects*; D001487:Basidiomycota / Q000737:chemistry*; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D013997:Time Factors
C036071:ergosterol-5,8-peroxide; D004875:Ergosterol