Caveolins in the repair phase of acute renal failure after oxidative stress.
Ischaemia-reperfusion and toxic injury are leading causes of acute renal failure (ARF). Both of these injury initiators use secondary mediators of damage in oxygen-derived free radicals. Several recent publications about ischaemia-reperfusion and toxin-induced ARF have indicated that plasma membrane structures called caveolae, and their proteins, the caveolins, are potential participants in protecting or repairing renal tissues. Caveolae and caveolins have previously been ascribed many functions, a number of which may mediate cell death or survival of injured renal cells. This review proposes possible pathophysiological mechanisms by which altered caveolin-1 expression and localization may affect renal cell survival following oxidative stress.
Percy
Christine
C
Department of Molecular and Cellular Pathology, University of Queensland School of Medicine, Herston, Brisbane, Queensland, Australia.
Waters
Michael J
MJ
Gobé
Glenda
G
D058186:Acute Kidney Injury / Q000503:physiopathology*; D000818:Animals; D021941:Caveolae / Q000502:physiology; D022461:Caveolins / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D015398:Signal Transduction
D022461:Caveolins