title: The effect of lipopolysaccharide on cholecystokinin in murine plasma and tissue.
abstract: Several mechanisms have been proposed for neuroimmune communication supporting sickness behavior (fever, anorexia, inactivity, and cachexia) following infection. We examined the role of cholecystokinin as a neurochemical intermediary of sickness behavior by determining plasma, duodenum, hypothalamus, and brainstem cholecystokinin concentrations 30 and 60 min and 12 h following intraperitoneal lipopolysaccharide (LPS) (0.25 and 2.5 mg/kg). Hypothalamic cholecystokinin was significantly lower in LPS- versus saline-treated mice 30 min (0.25 and 2.5 mg/kg) and 12 h (2.5 mg/kg) post-injection. Plasma cholecystokinin of LPS-treated mice was significantly lower than that of controls 1 and 12 h post-injection, a finding consistent with a non-endocrine action of peripheral cholecystokinin.
authors.affiliation: School of Psychological Science, La Trobe University, Bundoora, Vic. 3086, Australia.
authors.forename: Tracey J
authors.initials: TJ
authors.lastname: Weiland
authors.forename: Stephen
authors.initials: S
authors.lastname: Kent
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Voudouris
authors.forename: Arthur
authors.initials: A
authors.lastname: Shulkes
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D001933:Brain Stem / Q000187:drug effects; D002766:Cholecystokinin / Q000097:blood / Q000378:metabolism* / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008070:Lipopolysaccharides / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000378:metabolism; D011863:Radioimmunoassay; D013997:Time Factors
chemical_list: D016207:Cytokines; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D002766:Cholecystokinin