title: Intraamygdaloid administration of BIBO 3304 increases water intake and extends anxiolytic effects.
abstract: The present study was designed to evaluate the effects of BIBO 3304 in the Vogel's conflict drinking test and in the water intake test in non-deprived rats after injection of the drug into the basolateral nucleus of the amygdaloid complex. BIBO 3304 was given at the doses of 25, 100 and 200 pmol/0.5 microl/site. We investigated also the effect of 5-hydroxytryptophan (5-HTP), given intraperitoneally at a dose of 20 mg/kg, which was used as a positive control in the water intake test. Water consumption was measured 1, 2, 4, 6 and 24 h after drug administration. We found that water intake was increased both after 5-HTP and BIBO 3304 administration.
authors.affiliation: Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland.
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Wierońska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Stachowicz
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kłodzińska
authors.forename: Maria
authors.initials: M
authors.lastname: Smiałowska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pilc
mesh_terms: D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy*; D001120:Arginine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior; D004333:Drug Administration Routes; D008297:Male; D051381:Rats
chemical_list: D014151:Anti-Anxiety Agents; D001120:Arginine; C117416:BIBO 3304