title: Successful treatment of resistant chronic hepatitis C virus infection with high dose pegylated interferon.
abstract: We present the case of a 49 years old male, who was HCV RNA positive with an ALT of 260, showing no response to standard interferon (INF) plus ribavirin treatment for 48 weeks and to a further therapy with high dose standard IFN plus ribavirin for 24 weeks. Pegylated (PEG) IFN was then started at a dose of 80 mcg/week with ribavirin, but proved to be of no avail. Finally, a dose of 120 mcg/week of PEG INF and ribavirin was administered for 48 weeks. This resulted in negative HCV RNA PCR after two months and remained undetectable with normal ALT. A six-month follow-up showed a sustained viral response.
authors.affiliation: Department of Medicine, Shifa International Hospital and Shifa College of Medicine, Islamabad, Pakistan. drnkhokar@yahoo.com
authors.forename: Nasir
authors.initials: N
authors.lastname: Khokhar
authors.forename: Mansur Basharat
authors.initials: MB
authors.lastname: Butt
authors.forename: Muzaffar Lateef
authors.initials: ML
authors.lastname: Gill
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D011994:Recombinant Proteins; D012254:Ribavirin / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b