Cytosporone E: racemic synthesis and preliminary antibacterial testing.
The antibiotic cytosporone E (isolated from the broth of the endophytic fungi CR 200 (Cytospora sp.) and CR 146 (Diaporthe sp.)) was synthesized as a racemic mixture. The key step in the synthesis is the Meyers ortho-alkylation of a chiral aromatic oxazoline. Preliminary antibiotic activity shows antibiosis against Gram-positive bacteria but not Gram-negative bacteria as previously reported.
Hall
Jeffrey D
JD
Department of Chemistry and Biochemistry, College of Charleston, 66 George Street, Charleston, SC 29424, USA.
Duncan-Gould
Nathan W
NW
Siddiqi
Nasar A
NA
Kelly
Jennifer N
JN
Hoeferlin
L Alexis
LA
Morrison
Susan J
SJ
Wyatt
Justin K
JK
D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests
D001572:Benzofurans; C492581:cytosporone E