Antinociceptive action of hemopressin in experimental hyperalgesia.
Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the alpha-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied. In this work, we examined the influence of hemopressin on inflammatory pain. Hemopressin reverted the hyperalgesia induced by either carrageenin or bradykinin when injected concomitantly or 2.5 h after the phlogistic agents. Hemopressin administered systemically also reverted the hyperalgesia induced by carrageenin. Naloxone did not prevent the antinociceptive action of this peptide. These data suggest that hemopressin inhibits peripheral hyperalgesic responses by mechanisms independent of opioid receptor activation.
Dale
Camila Squarzoni
CS
Laboratory of Pathophysiology, Butantan Institute, São Paulo, SP, Brazil.
Pagano
Rosana de Lima
Rde L
Rioli
Vanessa
V
Hyslop
Stephen
S
Giorgi
Renata
R
Ferro
Emer Suavinho
ES
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure; D001920:Bradykinin / Q000494:pharmacology; D002351:Carrageenan / Q000494:pharmacology; D004195:Disease Models, Animal; D004723:Endorphins; D006454:Hemoglobins / Q000737:chemistry / Q000494:pharmacology*; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D007249:Inflammation; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010146:Pain; D010147:Pain Measurement; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000737:chemistry; D013997:Time Factors
D000700:Analgesics; D004723:Endorphins; D006454:Hemoglobins; D009292:Narcotic Antagonists; D010446:Peptide Fragments; D010455:Peptides; D011957:Receptors, Opioid; C473218:hemopressin; D009270:Naloxone; D002351:Carrageenan; D001920:Bradykinin