title: A simple method of independent treatment time verification in gamma knife radiosurgery using integral dose.
abstract: The purpose of this study is to develop a simple independent dose calculation method to verify treatment plans for Leksell Gamma Knife radiosurgery. Our approach uses the total integral dose within the skull as an end point for comparison. The total integral dose is computed using a spreadsheet and is compared to that obtained from Leksell GammaPlan. It is calculated as the sum of the integral doses of 201 beams, each passing through a cylindrical volume. The average length of the cylinders is estimated from the Skull-Scaler measurement data taken before treatment. Correction factors are applied to the length of the cylinder depending on the location of a shot in the skull. The radius of the cylinder corresponds to the collimator aperture of the helmet, with a correction factor for the beam penumbra and scattering. We have tested our simple spreadsheet program using treatment plans of 40 patients treated with Gamma Knife in our center. These patients differ in geometry, size, lesion locations, collimator helmet, and treatment complexities. Results show that differences between our calculations and treatment planning results are typically within +/-3%, with a maximum difference of +/-3.8%. We demonstrate that our spreadsheet program is a convenient and effective independent method to verify treatment planning irradiation times prior to implementation of Gamma Knife radiosurgery.
authors.affiliation: Department of Radiation Oncology, Siteman Cancer Center, Washington University Medical Center, St Louis, Missouri 63110, USA. jjin1@hfhs.org
authors.forename: Jian-Yue
authors.initials: JY
authors.lastname: Jin
authors.forename: Robert
authors.initials: R
authors.lastname: Drzymala
authors.forename: Zuofeng
authors.initials: Z
authors.lastname: Li
mesh_terms: D000465:Algorithms; D001822:Body Burden; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D011785:Quality Assurance, Health Care / Q000379:methods*; D011874:Radiometry / Q000379:methods*; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors