Raf phosphorylation: one step forward and two steps back.
We understand Raf-1 activation relatively well but know less about how it is inactivated. An exciting study in this issue of Molecular Cell now describes the molecular basis underlying the transient nature of Raf-1 signaling.
Dumaz
Nicolas
N
Signal Transduction Team, Cancer Research UK Centre of Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, United Kingdom.
Marais
Richard
R
D004789:Enzyme Activation; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism; D010766:Phosphorylation; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D019908:Proto-Oncogene Proteins c-raf; D048049:Extracellular Signal-Regulated MAP Kinases; D020930:MAP Kinase Kinase Kinases