Daphmanidins C and D, novel pentacyclic alkaloids from Daphniphyllum teijsmanii.
[structure: see text] Two novel alkaloids with an unprecedented fused-pentacyclic skeleton, daphmanidins C (1) and D (2), have been isolated from the leaves of Daphniphyllum teijsmanii, and the structures were elucidated on the basis of spectroscopic data. The relative stereochemistry of 1 and 2 was assigned by combination of NOESY correlations and a simulation analysis. Daphmanidin C (1) elevated activity of NGF biosynthesis.
Morita
Hiroshi
H
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Ishioka
Nozomi
N
Takatsu
Hiroshi
H
Shinzato
Takakazu
T
Obara
Yutaro
Y
Nakahata
Norimichi
N
Kobayashi
Jun'ichi
J
D000470:Alkaloids / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009414:Nerve Growth Factors / Q000096:biosynthesis; D018515:Plant Leaves / Q000737:chemistry; D010944:Plants / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013268:Stimulation, Chemical
D000470:Alkaloids; D007202:Indicators and Reagents; D009414:Nerve Growth Factors; D011083:Polycyclic Compounds; D013141:Spiro Compounds; C510265:daphmanidin C; C510264:daphmanidin D