Synthesis and characterization of poly(ethylene oxide)-block-poly(methylidene malonate 2.1.2) block copolymers bearing a mannose group at the PEO chain end.
A poly(ethylene oxide)-block-poly(methylidene malonate 2.1.2) block copolymer (PEO-b-PMM 2.1.2) bearing a mannose moiety at the poly(ethylene oxide) chain end was synthesized by sequential anionic polymerization of ethylene oxide (EO) and methylidene malonate 2.1.2 (MM 2.1.2), followed by a coupling reaction between its poly(ethylene oxide) amino- or aldehyde-end group and a sugar derivative. Different coupling procedures, either in organic media or in aqueous micellar solutions, were examined in order to optimize the poly(ethylene oxide) end-glycosylation yield. The micellar size of the functionalized block copolymers was determined by dynamic light scattering.
Studer
Peggy
P
VIRSOL, 46 Rue Boissière, 75116 Paris, France.
Limal
David
D
Breton
Pascal
P
Riess
Gérard
G
D000447:Aldehydes / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D005027:Ethylene Oxide / Q000737:chemistry*; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D008314:Malonates / Q000138:chemical synthesis*; D008358:Mannose / Q000737:chemistry*; D008823:Micelles; D015394:Molecular Structure; D011095:Polyethylenes / Q000138:chemical synthesis*; D011108:Polymers / Q000138:chemical synthesis*; D012542:Scattering, Radiation
D000447:Aldehydes; D000596:Amino Acids; D008314:Malonates; D008823:Micelles; D011095:Polyethylenes; D011108:Polymers; C091414:poly(methylidene malonate) 2.1.2; D005027:Ethylene Oxide; D008358:Mannose