Heterophils are associated with resistance to systemic Salmonella enteritidis infections in genetically distinct chicken lines.
Heterophils mediate acute protection against Salmonella in young poultry. We evaluated susceptibility of genetically distinct lines of broilers to systemic Salmonella enteritidis (SE) infections. SE was administered into the abdomen of day-old chickens (parental lines [A and B]; F1 reciprocal crosses [C and D]) to assess modulation of leukocytes and survivability of chickens. Line A was more resistant to SE than line B; likewise cross D was more resistant than cross C. Significantly more heterophils migrated to the abdominal cavity post-infection in the resistant lines. These data indicate that increased heterophil influx to the infection site contributes to increased resistance against systemic SE infections in neonatal chickens.
Swaggerty
Christina L
CL
United States Department of Agriculture, Agricultural Research Services, SPARC, 2881 F&B Road, College Station, TX 77845, USA.
Ferro
Pamela J
PJ
Pevzner
Igal Y
IY
Kogut
Michael H
MH
D034841:Abdominal Cavity / Q000382:microbiology; D000818:Animals; D002465:Cell Movement; D002645:Chickens / Q000235:genetics / Q000276:immunology*; D007113:Immunity, Innate; D007958:Leukocyte Count; D009504:Neutrophils / Q000276:immunology*; D011201:Poultry Diseases / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000276:immunology*; D012477:Salmonella enteritidis / Q000276:immunology*; D016019:Survival Analysis