Activation of a unique population of CD8(+) T cells by intestinal epithelial cells.
Intestinal epithelial cells may play a role in the regulation of immune responses toward luminal antigens. We show that a subset of CD8(+) T cells undergoes oligoclonal expansion in the intestinal mucosa, probably through interaction with a unique complex expressed on epithelial cells, formed by a CEA subfamily member (gp180) and CD1d. This subset, which is regulatory in vitro, may play a role in the control of intestinal immune responses toward luminal antigens. A lack of expansion of these CD8(+) regulatory T cells, probably related to the defective expression of the gp180/CD1d complex, is observed in inflammatory bowel disease.
Allez
Matthieu
M
Immunobiology Center, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.
Brimnes
Jens
J
Shao
Ling
L
Dotan
Iris
I
Nakazawa
Atsushi
A
Mayer
Lloyd
L
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D018920:Coculture Techniques; D005452:Fluoresceins; D005456:Fluorescent Dyes; D006801:Humans; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology; D013388:Succinimides; D013601:T-Lymphocytes / Q000276:immunology
C087165:5-(6)-carboxyfluorescein diacetate succinimidyl ester; D005452:Fluoresceins; D005456:Fluorescent Dyes; D013388:Succinimides