title: Synthesis of a bulky and electron-rich derivative of SEGPhos and its application in Ru-catalyzed enantioselective hydrogenation of beta-ketoesters.
abstract: The synthesis and resolution of a bulky and electron-rich derivative of SEGPhos and its application in Ru-catalyzed asymmetric hydrogenation reaction of beta-ketoesters are reported. Up to 99.5% ee was achieved. Under solvent-free reaction conditions, acetoacetates could be reduced with good enantioselectivity and high efficiency; a TON of 20 000 was obtained within 3.5 h. The results obtained were comparable to those when SEGPhos was applied.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032, China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Wan
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Sun
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Luo
authors.forename: Dao
authors.initials: D
authors.lastname: Li
authors.forename: Zhaoguo
authors.initials: Z
authors.lastname: Zhang