title: Relationships between serotonin transporter promoter polymorphism, platelet serotonin transporter binding and clinical phenotype in suicidal and non-suicidal adolescent inpatients.
abstract: Relationships between the serotonin transporter promoter polymorphism (5-HTTLPR), platelet serotonin transporter (SERT) binding and clinical phenotype were examined in 32 suicidal and 28 non-suicidal Ashkenazi Israeli adolescent psychiatric inpatients. The 5-HTTLPR polymorphism was not associated with transporter binding or with suicidality or other clinical phenotypes. However, in the suicidal group, a significant positive correlation between platelet SERT density and anger scores (n=32, r=.40; p=.027) and a negative correlation between platelet count and trait anxiety (n=32, r=-.42; p=.034) were observed.
authors.affiliation: Adolescent Inpatient Department and Research Unit, Geha Mental Health Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. zalsman@columbia.edu
authors.forename: G
authors.initials: G
authors.lastname: Zalsman
authors.forename: G M
authors.initials: GM
authors.lastname: Anderson
authors.forename: M
authors.initials: M
authors.lastname: Peskin
authors.forename: A
authors.initials: A
authors.lastname: Frisch
authors.forename: R A
authors.initials: RA
authors.lastname: King
authors.forename: M
authors.initials: M
authors.lastname: Vekslerchik
authors.forename: E
authors.initials: E
authors.lastname: Sommerfeld
authors.forename: E
authors.initials: E
authors.lastname: Michaelovsky
authors.forename: L
authors.initials: L
authors.lastname: Sher
authors.forename: A
authors.initials: A
authors.lastname: Weizman
authors.forename: A
authors.initials: A
authors.lastname: Apter
mesh_terms: D000293:Adolescent; D000328:Adult; D000786:Anger / Q000502:physiology; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D006760:Hospitalization; D006778:Hospitals, Psychiatric; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010641:Phenotype; D010865:Pilot Projects; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011485:Protein Binding / Q000502:physiology; D050486:Serotonin Plasma Membrane Transport Proteins; D013405:Suicide
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins