The use of a novel biodegradable preparation capable of the sustained release of bacteriophages and ciprofloxacin, in the complex treatment of multidrug-resistant Staphylococcus aureus-infected local radiation injuries caused by exposure to Sr90.
In December 2001, three Georgian lumberjacks from the village of Lia were exposed to a strontium-90 source from two Soviet-era radiothermal generators they found near their village. In addition to systemic effects, two of them developed severe local radiation injuries which subsequently became infected with Staphylococcus aureus. After hospitalization in Tbilisi, Georgia, the patients were treated with various medications, including antibiotics and topical ointments; however, wound healing was only moderately successful, and their S. aureus infection could not be eliminated. Approximately 1 month after hospitalization, treatment with PhagoBioDerm (a wound-healing preparation consisting of a biodegradable polymer impregnated with ciprofloxacin and bacteriophages) was initiated. Purulent drainage stopped within 2-7 days. Clinical improvement was associated with rapid (7 days) elimination of the aetiologic agent, a strain of S. aureus resistant to many antibiotics (including ciprofloxacin), but susceptible to the bacteriophages contained in the PhagoBioDerm preparation.
Jikia
D
D
Tbilisi State Medical University, Tbilisi, Georgia, USA.
Chkhaidze
N
N
Imedashvili
E
E
Mgaloblishvili
I
I
Tsitlanadze
G
G
Katsarava
R
R
Glenn Morris
J
J
Sulakvelidze
Alexander
A
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001435:Bacteriophages; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations; D004352:Drug Resistance, Microbial; D005846:Georgia (Republic); D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus; D013326:Strontium Radioisotopes / Q000009:adverse effects; D014945:Wound Healing / Q000187:drug effects
D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D013326:Strontium Radioisotopes; D002939:Ciprofloxacin