Inhibition of breast adenocarcinoma growth by intratumoral injection of lipophilic long-acting lathyrogens.
Prevention of the formation of crosslinks and/or disintegration of already formed collagen fibrils in the tumor by known lathyrogens, beta-aminopropionitrile or D-penicillamine, may result in the weakening of tumor support, decreasing angiogenesis and promoting tumor regression. This paper reviews our studies with a single intratumoral injection of lipophilic lathyrogens and others, using a systemic administration to investigate the effect of both lathyrogens. Details of our experimental results are also given.
Chvapil
Milos
M
Arizona Cancer Center and Department of Surgery, University of Arizona, Tucson, AZ 85718, USA. mchvapil@hotmail.com
D000230:Adenocarcinoma / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D000629:Aminopropionitrile / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D004952:Esters / Q000737:chemistry; D005260:Female; D024022:Fibrillar Collagens / Q000378:metabolism; D015552:Injections, Intralesional; D015674:Mammary Neoplasms, Animal / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D010396:Penicillamine / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats
D000970:Antineoplastic Agents; D004952:Esters; D024022:Fibrillar Collagens; D000629:Aminopropionitrile; D010396:Penicillamine