title: RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women.
abstract: The RAD52 gene is involved in the homologous recombination repair pathway and is a plausible candidate ovarian cancer predisposition gene. We undertook a case-control comparison of 508 epithelial ovarian cancer cases (91 low malignant potential and 417 invasive) and 298 healthy controls to assess the RAD52 Y415X polymorphism as a risk factor for epithelial ovarian cancer in Australian women. Heterozygote frequencies of 2.6 and 4% were observed among cases and controls, respectively. The risk estimate was 0.55 (95%CI 0.24-1.24), suggesting that the RAD52 Y415X polymorphism is not associated with epithelial ovarian cancer in Australian women.
authors.affiliation: Cancer and Cell Biology Division, Queensland Institute of Medical Research and the University of Queensland, Brisbane, Australia.
authors.forename: Livia
authors.initials: L
authors.lastname: Kelemen
authors.forename: Amanda B
authors.initials: AB
authors.lastname: Spurdle
authors.forename: David M
authors.initials: DM
authors.lastname: Purdie
authors.forename: Dorota
authors.initials: D
authors.lastname: Gertig
authors.forename: Georgia
authors.initials: G
authors.lastname: Chenevix-Trench
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000209:etiology / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D051721:Rad52 DNA Repair and Recombination Protein / Q000235:genetics*; D012307:Risk Factors
chemical_list: C497194:RAD52 protein, human; D051721:Rad52 DNA Repair and Recombination Protein