Proneness to psychological distress and risk of Alzheimer disease in a biracial community.
Persons without dementia residing in a biracial community completed a brief scale of proneness to psychological distress, and 1,064 were subsequently examined for incident Alzheimer disease (AD) 3 to 6 years later. In analyses controlling for selected demographic and clinical variables, persons prone to distress were 2.4 times more likely to develop AD than persons not distress prone. This effect was substantially stronger in white persons compared to African Americans.
Wilson
R S
RS
Rush Alzheimer's Disease Center, Rush University Medical Center, Armour Academic Center, 600 S. Paulina, Suite 1038, Chicago, IL 60612, USA. rwilson@rush.edu
Barnes
L L
LL
Bennett
D A
DA
Li
Y
Y
Bienias
J L
JL
Mendes de Leon
C F
CF
Evans
D A
DA
D001741:Black or African American / Q000523:psychology*; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology*; D002641:Chicago / Q000453:epidemiology; D015331:Cohort Studies; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D012306:Risk; D012494:Sampling Studies; D013315:Stress, Psychological / Q000453:epidemiology*; D044465:White People / Q000523:psychology*