Oral administration of freeze-dried kefir reduces intestinal permeation of and oral sensitization to ovalbumin in mice.
An increase in plasma ovalbumin concentrations after intragastric administration of ovalbumin was suppressed by concomitant freeze-dried kefir in BALB/c mice. Serum levels of ovalbumin-specific immunoglobulin G and proliferation of splenic mononuclear cells in mice immunized orally with ovalbumin were suppressed by feeding freeze-dried kefir. We propose that kefir reduces intestinal permeation of food antigen, which contributes to suppression of oral sensitization.
Umeda
Chisato
C
Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
Sonoyama
Kei
K
Yamaguchi
Natsu
N
Saito
Ryo
R
Akashi
Keiko
K
Motoshima
Hidemasa
H
Kawabata
Jun
J
D000284:Administration, Oral; D000818:Animals; D000941:Antigens / Q000378:metabolism; D043302:Cultured Milk Products; D005260:Female; D005512:Food Hypersensitivity / Q000517:prevention & control*; D005612:Freeze Drying; D007408:Intestinal Absorption / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism*
D000941:Antigens; D010047:Ovalbumin