title: Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation.
abstract: To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype.
authors.affiliation: Center for Neurosciences, North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA.
authors.forename: K
authors.initials: K
authors.lastname: Asanuma
authors.forename: Y
authors.initials: Y
authors.lastname: Ma
authors.forename: J
authors.initials: J
authors.lastname: Okulski
authors.forename: V
authors.initials: V
authors.lastname: Dhawan
authors.forename: T
authors.initials: T
authors.lastname: Chaly
authors.forename: M
authors.initials: M
authors.lastname: Carbon
authors.forename: S B
authors.initials: SB
authors.lastname: Bressman
authors.forename: D
authors.initials: D
authors.lastname: Eidelberg
mesh_terms: D000328:Adult; D000368:Aged; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000493:pharmacokinetics; D004422:Dystonia Musculorum Deformans / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones / Q000235:genetics*; D049268:Positron-Emission Tomography; D011485:Protein Binding; D020891:Raclopride / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D017448:Receptors, Dopamine D2 / Q000172:deficiency* / Q000378:metabolism
chemical_list: D002250:Carbon Radioisotopes; D018492:Dopamine Antagonists; D018832:Molecular Chaperones; D019275:Radiopharmaceuticals; D017448:Receptors, Dopamine D2; C108175:TOR1A protein, human; D020891:Raclopride