title: Synthesis and antiparasitic properties of new 4-N-benzylamino-4-hetarylbut-1-enes.
abstract: New derivatives of 4-N-benzylamino-4-hetarylbut-1-ene containing a pyridyl nucleus were synthesized from benzylamines and pyridine aldehydes. N-oxide derivatives were obtained from these homoallylamines. Study of the antiparasitic properties of obtained pyridine derivatives as well as of four related benzazepines previously described, was carried out using cytotoxicity assays against Trichomonas vaginalis and epimastigote form of Trypanosoma cruzi protozoa. Compounds showing activity against epimastigote T. cruzi were tested against the amastigote form; unspecific cytotoxicity against macrophages was also studied.
authors.affiliation: Laboratory of Fine Organic Synthesis, Research Center for Biomolecules, School of Chemistry, Industrial University of Santander, AA 678, Bucaramanga, Colombia. kouznet@uis.edu.co
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Kouznetsov
authors.forename: Juliette Rivero
authors.initials: JR
authors.lastname: Castro
authors.forename: Cristian Ochoa
authors.initials: CO
authors.lastname: Puentes
authors.forename: Elena E
authors.initials: EE
authors.lastname: Stashenko
authors.forename: Jairo René
authors.initials: JR
authors.lastname: Martínez
authors.forename: Carmen
authors.initials: C
authors.lastname: Ochoa
authors.forename: David Montero
authors.initials: DM
authors.lastname: Pereira
authors.forename: Juan J Nogal
authors.initials: JJ
authors.lastname: Ruiz
authors.forename: Carlos Fernández
authors.initials: CF
authors.lastname: Portillo
authors.forename: Susana Muelas
authors.initials: SM
authors.lastname: Serrano
authors.forename: Alicia Gómez
authors.initials: AG
authors.lastname: Barrio
authors.forename: Alí
authors.initials: A
authors.lastname: Bahsas
authors.forename: Juan
authors.initials: J
authors.lastname: Amaro-Luis
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D002073:Butanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013329:Structure-Activity Relationship; D014246:Trichomonas vaginalis / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000977:Antiparasitic Agents; D001593:Benzyl Compounds; D002073:Butanes