Helicobacter pylori infection in hemodialysis patients: susceptibility to amoxicillin and clarithromycin.
OBJECTIVE
To evaluate susceptibility of Helicobacter pylori to amoxicillin and clarithromycin in end-stage renal disease (ESRD) patients and non-uremic controls.


METHODS
The subjects with dyspeptic complaints were 33 ESRD patients and 46 age- and sex-matched non-uremic controls who exhibited H pylori on antral biopsy specimens. The two groups were age and sex matched. The H pylori strains' pattern of susceptibility to amoxicillin and clarithromycin was investigated with the agar dilution technique.


RESULTS
None of the H pylori strains from either group showed resistance to amoxicillin with the agar dilution method. Twelve (36.4%) of the ESRD group strains and 7 (15.2%) of the control group strains showed resistance to clarithromycin, and this difference was statistically significant (P<0.05).


CONCLUSIONS
Resistance to amoxicillin does not appear to be an important problem in H pylori-infected ESRD and non-uremic patients in our region. In contrast, the rates of resistance to clarithromycin are high, particularly in the ESRD population.
Aydemir
Selim
S
Department of Gastroenterology, Zonguldak Karaelmas University Faculty of Medicine, 67800, Zonguldak, Turkey. selimaydemir@hotmail.com
Boyacioglu
Sedat
S
Gur
Gurden
G
Demirbilek
Muge
M
Can
Fusun-Kamber
FK
Korkmaz
Murat
M
Yilmaz
Ugur
U
D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage*; D000668:Ampicillin Resistance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001706:Biopsy; D017291:Clarithromycin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000150:complications / Q000628:therapy
D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D017291:Clarithromycin