A case of multiple cavernous hemangiomas with skin and central nervous system involvement.
A 47-year-old woman presented with multiple bluish subcutaneous nodules on the trunk and upper extremities. The histological diagnosis of a subcutaneous nodule was cavernous hemangioma. Multiple cavernous hemangiomas were also found in her cerebrum, cerebellum, and medulla oblongata on magnetic resonance imaging examination. We did not detect any mutations in the two loci of the TIE2 gene that have been reported in familial venous malformations.
Ebara
Naoki
N
Department of Dermatology, Nara Medical University, 840 Shijocho, Kashihara City, Nara 634-8522, Japan.
Asada
Hideo
H
Miyagawa
Sachiko
S
D001483:Base Sequence; D001707:Biopsy, Needle; D016543:Central Nervous System Neoplasms / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006392:Hemangioma, Cavernous / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D008969:Molecular Sequence Data; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*
D004273:DNA, Neoplasm