title: Successful management of central nervous system infection due to Propionibacterium acnes with vancomycin and doxycycline.
abstract: Propionibacterium acnes is an infrequent but increasingly recognized cause of neurosurgical infections. In this setting, it has been most commonly reported as complicating neurosurgical shunt procedures. The optimum therapy for central nervous system infections caused by P. acnes has not been established. The authors report on a patient who had development of P. acnes central nervous system infection after craniotomy for subdural hematoma. This case was successfully treated with prolonged therapy with vancomycin and doxycycline. Neurologic symptom improvement and radiographic resolution were documented on this regimen, and neurosurgical intervention was not required.
authors.affiliation: Section of Infectious Diseases, Department of Internal Medicine, Medical College of Georgia, Augusta, GA, USA. mfincher5@yahoo.com
authors.forename: Michael E
authors.initials: ME
authors.lastname: Fincher
authors.forename: Mary
authors.initials: M
authors.lastname: Forsyth
authors.forename: Scott Y
authors.initials: SY
authors.lastname: Rahimi
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001927:Brain Diseases / Q000188:drug therapy*; D004318:Doxycycline / Q000627:therapeutic use*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011425:Propionibacterium acnes; D014640:Vancomycin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D004318:Doxycycline