title: Real-time perfusion adenosine stress echocardiography in the coronary care unit: a feasible bedside tool for predicting coronary artery stenosis in patients with acute coronary syndrome.
abstract: Myocardial contrast echocardiography using power modulation real-time perfusion (RTP) is an appealing method for bedside risk stratification of patients with acute coronary syndrome. In this study, we aimed to evaluate the accuracy in predicting significant coronary stenosis of a bedside RTP adenosine stress protocol in patients with acute coronary syndrome.
  
  
  METHODS
  Prior to coronary angiography, 36 consecutive in-patients with acute coronary syndrome underwent a bedside adenosine stress echocardiography with RTP in the coronary care unit. Visual assessment of both perfusion and wall motion was made, comparing rest and hyperaemia images. Each segment was attributed to one of the three main coronary vessel areas.
  
  
  RESULTS
  The sensitivity of predicting significant stenosis was 87, 83 and 81% for left anterior descending, circumflex and right posterior descending areas, respectively. Specificity was 69, 67 and 60%, respectively. The positive predictive values were 83, 79 and 74%, respectively.
  
  
  CONCLUSIONS
  RTP using adenosine is a feasible bedside tool in predicting the area of significant coronary stenosis and could be helpful as a bedside decision-making tool in the clinical setting. More studies are required to assess the clinical value of RTP adenosine stress echocardiography.
authors.affiliation: Department of Cardiology, Malmö University Hospital, S-205 02 Malmö, Sweden. reidar.winter@skane.se
authors.forename: Reidar
authors.initials: R
authors.lastname: Winter
authors.forename: Petri
authors.initials: P
authors.lastname: Gudmundsson
authors.forename: Ronnie
authors.initials: R
authors.lastname: Willenheimer
mesh_terms: D000208:Acute Disease; D000241:Adenosine; D000368:Aged; D000369:Aged, 80 and over; D003325:Coronary Care Units; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D025401:Echocardiography, Stress / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging; D019095:Point-of-Care Systems; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity
chemical_list: D000241:Adenosine