Effect of carnosine on immunocompetent cells from alcoholic patients.
We studied the effect of natural dipeptide carnosine on phagocytosis, respiratory burst in neutrophils, and subpopulation composition of lymphocytes from healthy donors and alcoholic patients. Carnosine in vitro produced different effects on immunocompetent cells from healthy donors and patients with alcoholism. In patients with alcoholism phagocytic activity of leukocytes and generation of reaction oxygen species increased under the influence of carnosine in a concentration of 0.01 mM, but decreased after treatment with this compound in a concentration of 1 mM. Carnosine in both concentrations stimulated the respiratory burst, but had no effect on the count of phagocytic cells in healthy donors. Carnosine in a concentration of 0.01 mM increased the number of lymphocytes carrying apoptosis markers (CD95+) in patients with alcoholism not receiving therapy. Our results indicate that carnosine holds much promise for the therapy of alcoholism.
Nevidimova
T I
TI
Institute of Mental Health, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences. otyulina@mail.ru
Prokop'eva
V D
VD
Naidenova
N N
NN
Tyulina
O V
OV
Bokhan
N A
NA
D000437:Alcoholism / Q000276:immunology*; D002336:Carnosine / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000032:analysis; D016897:Respiratory Burst / Q000187:drug effects
D017382:Reactive Oxygen Species; D002336:Carnosine