Genetic selection for susceptibility to oral tolerance leads to a profound reduction of the acute inflammatory response.
Strains of mice obtained by genetic selection to extremes of phenotype for susceptibility or resistance to oral tolerance were investigated for possible genetic correlations with acute inflammatory response using different models of inflammation. The results show a strong genetic association.
da Silva
Maria de Fátima Sarro
Mde F
Laboratório de Imunobiologia, Departamento Biologia Celular e Genética, Instituto de Biologia, UERJ, Rua S. Francisco Xavier, 524, PHLC, Maracanã, Rio de Janeiro, RJ, Brasil, CEP 20.559-900. dasilva@uerj.br
da Nóbrega
Alberto
A
Barja-Fidalgo
Tereza Cristina
TC
Brando-Lima
Aline C
AC
Cunha
Fernando
F
da Silva
Antonio Carlos
AC
D000208:Acute Disease; D000818:Animals; D000941:Antigens / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology*; D007108:Immune Tolerance; D018928:Immunity, Mucosal; D007249:Inflammation / Q000276:immunology* / Q000517:prevention & control; D008070:Lipopolysaccharides / Q000276:immunology / Q000633:toxicity; D051379:Mice; D009061:Mouth Mucosa / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology
D000941:Antigens; D008070:Lipopolysaccharides; D010047:Ovalbumin