Mechanisms of cancer cell invasion.
The movement of cancer cells into tissue surrounding the tumour and the vasculature is the first step in the spread of metastatic cancers. Recent advances in imaging, the use of 3D model systems and the application of microarray technologies have yielded new insights into these processes. This work has challenged our views about what causes cancer cells to become motile in the first place, and has demonstrated that cancer cells can move in many different ways.
Sahai
Erik
E
Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK. erik.sahai@cancer.org.uk
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D009154:Mutation; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology* / Q000517:prevention & control; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology