Study of the Michael addition of beta-cyclodextrin-thiol complexes to conjugated alkenes in water.
An environmentally benign and highly efficient supramolecular Michael addition of thiols from the secondary side of beta-cyclodextrin to alpha,beta-unsaturated compounds at the primary side in water is described in quantitative yields; products of undesirable side reactions resulting from polymerization are not observed; the use of cyclodextrin precludes the use of either acid or base and the catalyst can be recovered and reused.
Krishnaveni
N Srilakshmi
NS
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500007, India.
Surendra
K
K
Rao
K Rama
KR