[Sero-epidemiological characteristics of antibody to SARS-associated coronavirus in Gansu Province].
OBJECTIVE
To study the levels of SARS-associated coronavirus IgG antibody of SARS patients, people who closely contacted SARS patients and normal subjects in Gansu province.


METHODS
The levels of SARS-associated coronavirus IgG antibody were measured by ELISA. The material included acute and (or) recovery period sera of 9 SARS patients, sera from 1,109 doctors and nurses closely contacted with SARS patients, laboratory workers, personnel for disease control and prevention, persons who contacted SARS patients, and sera from 978 normal subjects.


RESULTS
SARS coronavirus IgG antibody was detected positive in 6 of the 9 patients, it was still positive in the sera twelve months after recovery; 1 of the closely contacted persons and 3 normal subjects were found positive.


CONCLUSIONS
The positive rate of SARS coronavirus IgG antibody of patients was consistent with the clinical diagnosis. The low positive rate of the persons who closely contacted SARS patients and normal subjects suggests that SARS probably had no subclinical infection.
Yu
De-shan
DS
Department of Acute Infectious Disease Control and Prevention, Gansu Centers for Disease Control and Prevention, Lanzhou 730000, China.
Fu
Shi-hong
SH
Meng
Lei
L
Jiang
Jian-xiang
JX
Wang
Bing-tao
BT
Wang
Jian
J
Wang
Li-hua
LH
He
Ying
Y
Liang
Guo-dong
GD
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002681:China / Q000453:epidemiology; D006282:Health Personnel; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D017758:Infectious Disease Transmission, Patient-to-Professional / Q000032:analysis; D008875:Middle Aged; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology*; D045169:Severe Acute Respiratory Syndrome / Q000453:epidemiology / Q000276:immunology* / Q000635:transmission
D000914:Antibodies, Viral; D007074:Immunoglobulin G