RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women.
The RAD52 gene is involved in the homologous recombination repair pathway and is a plausible candidate ovarian cancer predisposition gene. We undertook a case-control comparison of 508 epithelial ovarian cancer cases (91 low malignant potential and 417 invasive) and 298 healthy controls to assess the RAD52 Y415X polymorphism as a risk factor for epithelial ovarian cancer in Australian women. Heterozygote frequencies of 2.6 and 4% were observed among cases and controls, respectively. The risk estimate was 0.55 (95%CI 0.24-1.24), suggesting that the RAD52 Y415X polymorphism is not associated with epithelial ovarian cancer in Australian women.
Kelemen
Livia
L
Cancer and Cell Biology Division, Queensland Institute of Medical Research and the University of Queensland, Brisbane, Australia.
Spurdle
Amanda B
AB
Purdie
David M
DM
Gertig
Dorota
D
Chenevix-Trench
Georgia
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000209:etiology / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D051721:Rad52 DNA Repair and Recombination Protein / Q000235:genetics*; D012307:Risk Factors
C497194:RAD52 protein, human; D051721:Rad52 DNA Repair and Recombination Protein