DNA adduction and mutagenic properties of acrylamide.
This review article summarizes our current knowledge on DNA damaging and mutagenic properties of acrylamide. Direct and indirect modes of interaction of acrylamide with DNA are discussed, and the resulting alkylating DNA adducts are highlighted. Emphasis is placed on glycidamide-DNA adducts generated via epoxidation of acrylamide presumably by cytochrome P4502E1. Dosimetry and mapping of acrylamide-induced DNA adducts in vitro and/or in vivo are described. Mutagenic potency and specificity of acrylamide in relation to its respective DNA adducts are discussed. Prospective views are provided on the potential applications of acrylamide-induced DNA adduct dosimetry/mapping and mutation frequency/spectrometry for biomonitoring purposes.
Besaratinia
Ahmad
A
Department of Biology, Beckman Research Institute of the City of Hope, National Medical Center, 1450 East Duarte Road, Duarte, CA 91010, USA. ania@coh.org
Pfeifer
Gerd P
GP
D020106:Acrylamide / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D018736:DNA Adducts / Q000737:chemistry*; D004781:Environmental Exposure / Q000009:adverse effects; D015394:Molecular Structure; D009153:Mutagens / Q000633:toxicity*
D002273:Carcinogens; D018736:DNA Adducts; D009153:Mutagens; D020106:Acrylamide