Effect of MK-801 on sensitivity of the respiratory system to oxygen deficiency and organisms resistance to hypoxia.
We studied changes in organism's sensitivity and resistance to hypoxic hypoxia under conditions of NMDA receptor blockade with MK-801. Breathing hypoxic gas mixture after administration of MK-801 sharply decreased the mean blood pressure in the systemic circulation and slightly improved lung ventilation in animals. Respiratory arrest was observed in 40% animals. NMDA receptor blockade decreased organism's sensitivity and resistance to hypoxic hypoxia.
Tarakanov
I A
IA
Laboratory for Pathophysiology of Respiration, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. inspiration@mtu-net.ru
Dymetska
A
A
Tarasova
N N
NN
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000502:physiology; D012137:Respiratory System / Q000187:drug effects* / Q000503:physiopathology
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate