title: DNA topoisomerase I inhibitors from Rinorea anguifera.
abstract: An organic extract prepared from Rinorea anguifera was investigated in order to identify the natural principle(s) responsible for stabilization of a topoisomerase I-DNA covalent binary complex. Bioassay-guided fractionation resulted in the isolation of mauritianin and (+)-syringaresinol as new topoisomerase I inhibitors, and also of the known inhibitor camptothecin.
authors.affiliation: Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, VA 22901, USA.
authors.forename: Ji
authors.initials: J
authors.lastname: Ma
authors.forename: Shannon H
authors.initials: SH
authors.lastname: Jones
authors.forename: Rebekah
authors.initials: R
authors.lastname: Marshall
authors.forename: Xihan
authors.initials: X
authors.lastname: Wu
authors.forename: Sidney M
authors.initials: SM
authors.lastname: Hecht
mesh_terms: D002166:Camptothecin / Q000302:isolation & purification; D004247:DNA / Q000378:metabolism; D004264:DNA Topoisomerases, Type I / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000302:isolation & purification*; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D044949:Kaempferols / Q000302:isolation & purification / Q000494:pharmacology; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts; D010946:Plants, Medicinal / Q000737:chemistry*; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D005663:Furans; D044949:Kaempferols; D017705:Lignans; D010936:Plant Extracts; D059004:Topoisomerase I Inhibitors; C069907:mauritianin; C042192:syringaresinol; D004247:DNA; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin