Electrophysiological indices associated with social functioning outcome in schizophrenia: a 5-year follow-up study.
We previously demonstrated that event-related potentials (ERPs), such as N1/N2b amplitudes in an auditory selective attention task, were significantly associated with communication skills of schizophrenia. The present study investigated the relationship between N1/N2b amplitudes and the quality of life (QOL) 5 years after ERP measurement. QOL of 15 patients with schizophrenia was assessed using the quality of life scale (QLS). Correlational analyses revealed a significant relationship between N2b, but not N1, amplitude and specific domains of QOL. N2b amplitude, an electrophysiological index of orienting response, may be associated with longitudinal social functioning outcome in schizophrenia.
Maeda
Keiko
K
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.
Nakagome
Kazuyuki
K
Kasai
Kiyoto
K
Ikebuchi
Emi
E
Iwanami
Akira
A
Kudoh
Noriko
N
Araki
Tsuyoshi
T
Fukuda
Masato
M
D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000704:Analysis of Variance; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011581:Psychological Tests / Q000706:statistics & numerical data; D011788:Quality of Life; D011930:Reaction Time; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013223:Statistics as Topic