title: Heterozygous hemophilia developed during pregnancy.
abstract: In rare cases, patients with heterozygous hemophilia show bleeding tendency due to a low factor VIII activity of <20%. Here we describe a case of heterozygous hemophilia that developed during pregnancy. The patient was a 33-year-old Japanese woman whose father and brother both showed elevated nasal bleeding tendencies. However, they had received no medication for this condition. At 26 weeks' gestation she experienced heavy nasal bleeding. The prothrombin time and platelet count were normal, but the activated partial thromboplastin time was prolonged. Premature rupture of the membrane occurred, and an emergency cesarean section was carried out at 28 weeks' gestation. A diagnosis of heterozygous hemophilia was made after the cesarean section. Hemophilia crisis and heterozygous hemophilia require special obstetric care, with close liaison with a hematologist. Guidelines for the management of such cases should be available and observed.
authors.affiliation: Department of Obstetrics and Gynecology, National Hospital Organization, Kofu National Hospital, Yamanashi, Japan. yfukada@res.yamanashi-med.ac.jp
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Fukada
authors.forename: Takashi
authors.initials: T
authors.lastname: Shima
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kawashima
authors.forename: Shuji
authors.initials: S
authors.lastname: Hirata
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hoshi
mesh_terms: D000328:Adult; D002585:Cesarean Section; D003937:Diagnosis, Differential; D005260:Female; D006467:Hemophilia A / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000175:diagnosis*; D011517:Prothrombin Time