A role for the Wilms' tumor protein WT1 in organ development.
Wilms' tumor (nephroblastoma) represents a unique example of an aberrant kidney formation that can result from mutations in a tumor suppressor gene, Wilms' tumor 1 (WT1). Targeted gene inactivation in mice testifies that WT1 is a master switch for the development of the genitourinary system and other organs.
Scholz
Holger
H
Johannes-Müller-Institut für Physiologie, Charité-Universitätsmedizin Berlin, Berlin, Germany. holger.scholz@charite.de
Kirschner
Karin M
KM
D000818:Animals; D047108:Embryonic Development / Q000502:physiology; D006321:Heart / Q000196:embryology*; D006801:Humans; D007668:Kidney / Q000196:embryology* / Q000502:physiology; D025721:WT1 Proteins / Q000502:physiology*
D025721:WT1 Proteins