title: Toxic epidermal necrolysis syndrome--management and case report.
abstract: Toxic epidermal necrolysis syndrome [known also as Lyell's syndrome] is a severe drug reaction, characterized by fever. systemic toxicity, extensive skin rash with blisters and exfoliation similar to that of major burns. It carries an average mortality rate of 25%. The data concerning most frequent triggering agents and the differential diagnosis is presented; An overview of the management protocol for these patient in the Burn Center of the Lebanese Hospital is exposed with a case presentation of a young woman who sustained a 95% body surface area [BSA] cutaneous loss after the ingestion of only 2 tablets of amoxycilline documented by the complication and evolution.
authors.affiliation: Department of Anesthesiology, Burn Center, Lebanese Hospital, Beirut.
authors.forename: J C
authors.initials: JC
authors.lastname: Najem
authors.forename: N
authors.initials: N
authors.lastname: Raphael
authors.forename: G
authors.initials: G
authors.lastname: Ghanime
authors.forename: R
authors.initials: R
authors.lastname: Karam
authors.forename: H
authors.initials: H
authors.lastname: Tohme
authors.forename: Z
authors.initials: Z
authors.lastname: Moukarzel
authors.forename: J
authors.initials: J
authors.lastname: Achy
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin