Cubic phases and cubic phase dispersions in a phospholipid-based system.
A cubic liquid crystalline phase forming system based on the phospholipid dioleoylphosphatidylethanolamine (DOPE) which is fortified with small amounts of PEGylated (poly(ethylene) glycol) glycerol monooleate (PEG(660)-GMO) is characterized. The cubic phase formed by the DOPE/PEG(660)-GMO/water system coexists with water in the dilute part of the phase diagram and can be fragmented into colloidal size particles with retained cubic phase structure.
Johnsson
Markus
M
Camurus AB, Ideon, Gamma 2, Sölvegatan 41, SE-223 70, Lund, Sweden, and Physical Chemistry 1, Center for Chemistry and Chemical Engineering, Lund University, PO Box 124, SE-221 00 Lund, Sweden. markus.johnsson@camurus.ideon.se
Barauskas
Justas
J
Tiberg
Fredrik
F
D046529:Microscopy, Electron, Transmission; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D014961:X-Ray Diffraction
C410262:1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D011092:Polyethylene Glycols