Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying.
To investigate the effect of oral glucose intake on gastric motility, we measured gastric myoelectrical activity and gastric emptying on two test conditions: 1) glucose intake and 2) water intake in the same 10 healthy male volunteers (20 to 29 years old). Gastric motility was evaluated with cutaneous-recorded electrogastrography (EGG) for 30 min both on fasting and after glucose or water intake, while gastric emptying was measured using acetaminophen-absorption method. There were no significant changes in EGG dominant frequency after water intake, but the frequency increased significantly after glucose intake. A postprandial dip (i.e., a transient decrease in frequency immediately after the food intake) was observed in 3 subjects after water intake and in 8 subjects following glucose intake. The EGG power ratio was significantly larger after glucose than water intake, with delayed gastric emptying in the former case. These results suggest that glucose is one of the components responsible for postprandial gastric motility.
Misu
Naoko
N
Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya 467-8601, Japan. k7misu@go4.enjoy.ne.jp
Kamiya
Takeshi
T
Kobayashi
Yuka
Y
Hirako
Makoto
M
Nagao
Toshihiro
T
Shikano
Michiko
M
Matsuhisa
Eriko
E
Ando
Takashi
T
Adachi
Hiroshi
H
Kimura
Genjiro
G
D000284:Administration, Oral; D000328:Adult; D004326:Drinking; D004576:Electromyography; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology*; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009130:Muscle, Smooth / Q000502:physiology*; D013270:Stomach / Q000502:physiology*
D005947:Glucose