title: Bethanecol chloride for treatment of clomipramine-induced orgasmic dysfunction in males.
abstract: OBJECTIVE
  To investigate whether bethanecol chloride may be an alternative for the clinical management of clomipramine-induced orgasmic dysfunction, reported to occur in up to 96% of male users.
  
  
  METHODS
  In this study, 12 fully remitted panic disorder patients, complaining of severe clomipramine-induced ejaculatory delay, were randomly assigned to either bethanecol chloride tablets (20 mg, as needed) or placebo in a randomized, double-blind, placebo-controlled, two-period crossover study. A visual analog scale was used to assess severity of the orgasmic dysfunction.
  
  
  RESULTS
  A clear improvement was observed in the active treatment period. No placebo or carry-over effects were observed.
  
  
  CONCLUSIONS
  These findings suggest that bethanecol chloride given 45 minutes before sexual intercourse may be useful for clomipramine-induced orgasmic dysfunction in males.
authors.affiliation: Anxiety Clinic, Department of Psychiatry, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil. amban@amban.org.br
authors.forename: Márcio
authors.initials: M
authors.lastname: Bernik
authors.forename: Antonio Hélio Guerra
authors.initials: AH
authors.lastname: Vieira
authors.forename: Paula Villela
authors.initials: PV
authors.lastname: Nunes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D018723:Bethanechol / Q000627:therapeutic use*; D002997:Clomipramine / Q000009:adverse effects*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004542:Ejaculation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000188:drug therapy; D010277:Parasympathomimetics / Q000627:therapeutic use*; D012720:Severity of Illness Index; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000929:Antidepressive Agents, Tricyclic; D010277:Parasympathomimetics; D018723:Bethanechol; D002997:Clomipramine