title: Fluid dynamic analysis in a human left anterior descending coronary artery with arterial motion.
abstract: A computational fluid dynamic (CFD) analysis is pre sented to describe local flow dynamics in both 3-D spatial and 4-D spatial and temporal domains from reconstructions of intravascular ultrasound (IVUS) and bi-plane angiographic fusion images. A left anterior descending (LAD) coronary artery segment geometry was accurately reconstructed and subsequently its motion was incorporated into the CFD model. The results indicate that the incorporation of motion had appreciable effects on blood flow patterns. The velocity profiles in the region of a stenosis and the circumferential distribution of the axial wall shear stress (WSS) patterns in the vessel are altered with the wall motion introduced in the simulation. The time-averaged axial WSS between simulations of steady flow and unsteady flow without arterial motion were comparable (-0.3 to 13.7 Pa in unsteady flow versus -0.2 to 10.1 Pa in steady flow) while the magnitudes decreased when motion was introduced (0.3-4.5 Pa). The arterial wall motion affects the time-mean WSS and the oscillatory shear index in the coronary vessel fluid dynamics and may provide more realistic predictions on the progression of atherosclerotic disease.
authors.affiliation: Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Ramaswamy
authors.forename: S C
authors.initials: SC
authors.lastname: Vigmostad
authors.forename: A
authors.initials: A
authors.lastname: Wahle
authors.forename: Y G
authors.initials: YG
authors.lastname: Lai
authors.forename: M E
authors.initials: ME
authors.lastname: Olszewski
authors.forename: K C
authors.initials: KC
authors.lastname: Braddy
authors.forename: T M H
authors.initials: TM
authors.lastname: Brennan
authors.forename: J D
authors.initials: JD
authors.lastname: Rossen
authors.forename: M
authors.initials: M
authors.lastname: Sonka
authors.forename: K B
authors.initials: KB
authors.lastname: Chandran
mesh_terms: D001783:Blood Flow Velocity; D003198:Computer Simulation; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D003326:Coronary Circulation; D003331:Coronary Vessels; D020342:Finite Element Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D008955:Models, Cardiovascular; D009716:Numerical Analysis, Computer-Assisted; D011673:Pulsatile Flow; D011859:Radiography; D033081:Shear Strength; D013314:Stress, Mechanical