Liposome-bilirubin interaction: a novel strategy to eliminate bilirubin from systemic circulation.
In the present study, we established the role of liposomes in removal of bilirubin from systemic circulation of the hyperbilirubinemic rats. Bilirubin has been demonstrated to possess inherent tendency to interact with liposomes through ionic as well as hydrophobic interactions. The size as well as lamellarity of the liposomes does not seem to affect their binding with bilirubin. However, the charge on the surface of liposomes plays an important role in bilirubin-liposome interaction, e.g., bilirubin binds more extensively with positively charged liposomes as compared to the neutral or negatively charged liposomes. The present study further demonstrates that liposomes were effective in reducing the increased plasma bilirubin level in hyperbilirubinemic model animals as well. The results of the study suggest that positively charged liposome-mediated selective homing of excess plasma bilirubin to the hepatocytes seems to offer an important strategy in management of hyperbilirubinemic conditions.
Masood
Alam Khan
AK
Inter-disciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India.
Moin
Shagufta
S
Tayyab
Saad
S
Abul
Faiz Faizi
FF
Siddiqui
Mashiatulla
M
Owais
Mohammad
M
D000818:Animals; D001663:Bilirubin / Q000097:blood* / Q000302:isolation & purification*; D004563:Electrochemistry; D006932:Hyperbilirubinemia / Q000097:blood / Q000628:therapy; D066298:In Vitro Techniques; D008081:Liposomes / Q000097:blood* / Q000737:chemistry / Q000627:therapeutic use; D008297:Male; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar
D008081:Liposomes; D001663:Bilirubin