title: Dynamic magnetic resonance imaging in determining histopathological prognostic factors of invasive breast cancers.
abstract: OBJECTIVE
  To evaluate the relation between morphological features and enhancement parameters in dynamic contrast-enhanced magnetic resonance (DCE-MR) imaging with histopathological prognostic factors.
  
  
  METHODS
  Fifty-five patients with surgicopathological diagnosis of breast carcinoma were evaluated with 1.0 T MR scanner as a part of their preoperative diagnostic work-up. Dynamic studies were performed in axial plane using 3D fast low angle shot (FLASH) sequence. Time intensity curves (TICs) were obtained from the regions showing maximal enhancement in subtraction images. The correlations between enhancement parameters and histopathological findings were analyzed using stepwise multiple regression analysis, Student's t-test, chi(2)-tests and Pearson's moment correlation coefficient.
  
  
  RESULTS
  Significant correlations were found between the presence of lymph node metastasis and tumor size (P < 0.05) and edge characteristics (P < 0.05). A highly significant correlation was found between histopathological grades and qualitative enhancement patterns (r = 0.403, P < 0.01). Statistically significant differences were found between the groups with and without lymph node metastasis regarding enhancement in the first minute (P < 0.01) and TIC slope (P < 0.05). A significant difference was found between the histopathological grades I and III regarding all quantitative enhancement parameters, whereas no difference was found between the grades I-II, and II-III.
  
  
  CONCLUSIONS
  DCE-MR imaging helps to predict prognostic factors of breast cancer by revealing morphological features and enhancement parameters of the primary tumor. Additional morphological factors further improve our ability to predict lymphatic metastasis.
authors.affiliation: Department of Radiology, Trakya University Medical Faculty, Edirne, Turkey. drtuncbilek@hotmail.com
authors.forename: Nermin
authors.initials: N
authors.lastname: Tuncbilek
authors.forename: Hakki Muammer
authors.initials: HM
authors.lastname: Karakas
authors.forename: Ozerk Omur
authors.initials: OO
authors.lastname: Okten
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000473:pathology*; D016009:Chi-Square Distribution; D003287:Contrast Media; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012044:Regression Analysis
chemical_list: D003287:Contrast Media