[Proteasome and proteolysis].
The maintenance of cellular homeostasis and the ability of cells to respond to their environment depend on the degradation of bulk proteins and orderly degradation of key regulatory proteins and their inhibitors. The 26S proteasome plays an essential role in these degradations. It is involved in the activation and inactivation of many cellular processes such as cell cycle progression, apoptosis and regulation of gene expression. It presents unique structural and functional properties. It degrades proteins by an unusual mechanism. Several series of proteasome inhibitors have been developed, useful to elucidate the biological roles of this multicatalytic enzyme. Velcade (bortezomid) was the first proteasome inhibitor to undergo, in may 2003, clinical trials in cancer patients.
Papapostolou
David
D
Laboratoire d Enzymologie Moléculaire et Fonctionnelle, Département de Biologie, Institut Jacques Monod, UMR 7592, CNRS-Universités Paris 6 & 7, Tour 43, 2, place Jussieu, 75251 Paris Cedex 05, France.
Reboud-Ravaux
Michèle
M
D000375:Aging / Q000378:metabolism; D000818:Animals; D006801:Humans; D006868:Hydrolysis; D008954:Models, Biological; D008958:Models, Molecular; D010084:Oxidation-Reduction; D011480:Protease Inhibitors / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D021122:Protein Subunits; D011506:Proteins / Q000378:metabolism*; D013329:Structure-Activity Relationship; D025801:Ubiquitin / Q000378:metabolism
D011480:Protease Inhibitors; D021122:Protein Subunits; D011506:Proteins; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex