title: Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT(7) receptor.
abstract: The synthesis of novel C6-aryl substituted derivatives of 3-(dimethylamino)chroman is described. The novel derivatives display 5-HT(7) receptor affinities that varies from nM to muM, indicating that this small set of derivatives constitute a novel and interesting starting point for further structure-serotonin 5-HT(7) activity relationship (SAR) studies.
authors.affiliation: Organic Pharmaceutical Chemistry, Uppsala University, PO Box 574, SE-751 23 Uppsala, Sweden.
authors.forename: Pär
authors.initials: P
authors.lastname: Holmberg
authors.forename: Lars
authors.initials: L
authors.lastname: Tedenborg
authors.forename: Susanne
authors.initials: S
authors.lastname: Rosqvist
authors.forename: Anette M
authors.initials: AM
authors.lastname: Johansson
mesh_terms: D001665:Binding Sites; D002839:Chromans / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000737:chemistry* / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
chemical_list: D002839:Chromans; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C104425:serotonin 7 receptor