Macrophage migration inhibitory factor and activator protein-1 in ulcerative colitis.
Macrophage migration inhibitory factor (MIF) is a cytokine that has potent antisteroid effects. We determined that MIF is involved in the glucocorticoid-resistant inflammatory process of ulcerative colitis (UC), and the altered AP-1 signal is a potent therapeutic target for refractory UC.
Ishiguro
Yoh
Y
First Department of Internal medicine, Hirosaki University School of Medicine, 5 zaifu-cho, Hirosaki, Japan. yishi-hki@umin.ac.jp
Yamagata
Kazufumi
K
Sakuraba
Hirotake
H
Munakata
Akihiro
A
Nakane
Akio
A
Morita
Takayuki
T
Nishihira
Jun
J
D000818:Animals; D003093:Colitis, Ulcerative / Q000276:immunology* / Q000628:therapy; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology*; D015398:Signal Transduction; D018808:Transcription Factor AP-1 / Q000276:immunology / Q000502:physiology*
D016207:Cytokines; D008263:Macrophage Migration-Inhibitory Factors; D018808:Transcription Factor AP-1