Microwave-assisted synthesis of novel thiazolocarbazoles and evaluation as potential anticancer agents. Part III.
Novel 6-substituted thiazolocarbazole derivatives have been synthesized under microwave irradiation via the corresponding imino-1,2,3-dithiazoles. In vitro antitumor potential of these polyheterocyclic compounds was evaluated. Among all the tested thiazolocarbazoles, compound 10 is the most effective in inhibiting cell growth.
Testard
Alexandra
A
Laboratoire de Biotechnologie et Chimie Bio-organique, FRE CNRS 2766, UFR Sciences Fondamentales et Sciences pour l'Ingénieur, Bâtiment Marie Curie, Université de la Rochelle, F-17042 La Rochelle cedex 1, France.
Picot
Laurent
L
Fruitier-Arnaudin
Ingrid
I
Piot
Jean-Marie
JM
Chabane
Hadjila
H
Domon
Lisianne
L
Thiery
Valerie
V
Besson
Thierry
T
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000528:radiation effects; D002227:Carbazoles / Q000138:chemical synthesis / Q000494:pharmacology / Q000528:radiation effects; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D066298:In Vitro Techniques; D008872:Microwaves; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology / Q000528:radiation effects
D000970:Antineoplastic Agents; D002227:Carbazoles; D013844:Thiazoles