A new scleroglucan/borax hydrogel: swelling and drug release studies.
The aim of the work was the characterization of a new polysaccharidic physical hydrogel, obtained from Scleroglucan (Sclg) and borax, following water uptake and dimension variations during the swelling process. Furthermore, the release of molecules of different size (Theophylline (TPH), Vitamin B12 (Vit. B12) and Myoglobin (MGB)) from the gel and from the dried system used as a matrix for tablets was studied. The increase of weight of the tablets with and without the loaded drugs was followed together with the relative variation of the dimensions. The dry matrix, in the form of tablets was capable, during the swelling process, to incorporate a relevant amount of solvent (ca. 20 g water/g dried matrix), without dissolving in the medium, leading to a surprisingly noticeable anisotropic swelling that can be correlated with a peculiar supramolecular structure of the system induced by compression. Obtained results indicate that the new hydrogel can be suitable for sustained drug release formulations. The delivery from the matrix is deeply dependent on the size of the tested model drugs. The experimental release data obtained from the gel were satisfactorily fitted by an appropriate theoretical approach and the relative drug diffusion coefficients in the hydrogel were estimated. The release profiles of TPH, Vit. B12 and MGB from the tablets have been analyzed in terms of a new mathematical approach that allows calculating of permeability values of the loaded drugs.
Coviello
Tommasina
T
Department of Chemistry and Technology of Biologically Active Compounds, Faculty of Pharmacy, University of Rome La Sapienza, P.le Aldo Moro 5, 00185 Rome, Italy. tommasina.coviello@uniroma1.it
Grassi
Mario
M
Palleschi
Antonio
A
Bocchinfuso
Gianfranco
G
Coluzzi
Gina
G
Banishoeib
Fateme
F
Alhaique
Franco
F
D016880:Anisotropy; D001881:Borates / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000639:trends; D016503:Drug Delivery Systems / Q000639:trends*; D004355:Drug Stability; D005936:Glucans / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D009211:Myoglobin / Q000493:pharmacokinetics; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013607:Tablets / Q000737:chemistry / Q000493:pharmacokinetics; D013806:Theophylline / Q000493:pharmacokinetics; D014805:Vitamin B 12 / Q000493:pharmacokinetics; D017155:Wettability
D001881:Borates; D005936:Glucans; D009211:Myoglobin; D013607:Tablets; C018851:borax; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C045938:scleroglucan; D013806:Theophylline; D014805:Vitamin B 12