Screening of anti-Helicobacter pylori herbs deriving from Taiwanese folk medicinal plants.
In this study, extracts from 50 Taiwanese folk medicinal plants were examined and screened for anti-Helicobacter pylori activity. Ninety-five percent ethanol was used for herbal extraction. Paederia scandens (Lour.) Merr. (PSM), Plumbago zeylanica L. (PZL), Anisomeles indica (L.) O. Kuntze (AIOK), Bombax malabaricum DC. (BMDC) and Alpinia speciosa (J. C. Wendl.) K. Schum. (ASKS) and Bombax malabaricum DC. (BMDC) all demonstrated strong anti-H. pylori activities. The minimum inhibitory concentration values of the anti-H. pylori activity given by the five ethanol herb extracts ranged from 0.64 to 10.24 mg ml(-1). Twenty-six herbs, including Artemisia argvi Levl. et Vant (AALEV), Phyla nodiflora (Linn.) Greene (PNG) and others, showed moderate anti-H. pylori activity. The additional 19 herbs, including Areca catechu Linn. (ACL), Euphorbia hirta Linn. (EHL) and Gnaphalium adnatum Wall. ex DC. (GAWEDC), possessed lower anti-H. pylori effects. About half of the Taiwanese folk medicinal plants tested, demonstrated to possess higher anti-H. pylori activity.
Wang
Yuan-Chuen
YC
Department of Food Science, National Chung-Hsing University, 250 Kuokuang Road, Taichung 40227, Taiwan, 402, ROC. ycwang@dragon.nchu.edu.tw
Huang
Tung-Liang
TL
D032429:Alpinia / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001114:Areca / Q000737:chemistry; D019306:Artemisia / Q000737:chemistry; D035163:Bombax / Q000737:chemistry; D028481:Euphorbia / Q000737:chemistry; D036622:Gnaphalium / Q000737:chemistry; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D029606:Plumbaginaceae / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry; D013624:Taiwan; D029648:Verbenaceae / Q000737:chemistry
D000900:Anti-Bacterial Agents; D010936:Plant Extracts