Genome sequence and attenuating mutations in West Nile virus isolate from Mexico.
The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.
Beasley
David W C
DW
University of Texas Medical Branch, Galveston, Texas 77555-0609, USA. d.beasley@utmb.edu
Davis
C Todd
CT
Estrada-Franco
Jose
J
Navarro-Lopez
Roberto
R
Campomanes-Cortes
Arturo
A
Tesh
Robert B
RB
Weaver
Scott C
SC
Barrett
Alan D T
AD
D000818:Animals; D001483:Base Sequence; D005260:Female; D016679:Genome, Viral; D008800:Mexico; D051379:Mice; D009154:Mutation; D014774:Virulence / Q000235:genetics; D014902:West Nile virus / Q000235:genetics* / Q000472:pathogenicity