title: Diagnostic value of simultaneous brachial and ankle blood pressure measurements for the extent and severity of coronary artery disease as assessed by myocardial perfusion imaging.
abstract: BACKGROUND
  Although the simultaneous measurement of brachial and ankle blood pressure is a simple method of evaluating atherosclerosis, its diagnostic value for coronary artery disease (CAD) is undetermined.
  
  
  RESULTS
  To evaluate the diagnostic value of ankle-brachial pressure index (ABI) and brachial-to-ankle pulse wave velocity (baPWV), 334 consecutive patients with suspected CAD were evaluated. Patients with a previous myocardial infarction or coronary intervention were not included. The magnitude of myocardial ischemia was evaluated by myocardial perfusion imaging. Using a 20-segment model, the percent of ischemic segments to total segments was expressed as %myocardium ischemic. In patients with < or =1, 2 and > or =3 coronary risk factors, %myocardium ischemic was 2.7+/-0.4, 4.0+/-0.5, 7.9+/-0.8%, respectively (p<0.0001 for trend). Performing ABI with a cutoff of 1, the %myocardium ischemic was similar in patients with < or =1 or 2 risk factors. In patients with > or =3 coronary risk factors, however, an ABI <1 reflected greater %myocardium ischemic than an ABI > or =1 (10.1+/-1.3, 6.6+/-1.0%; p=0.03). No such additional value was observed with baPWV.
  
  
  CONCLUSIONS
  The addition of simultaneous brachial and ankle blood pressure measurements will help further stratify patients with multiple risk factors. Although this approach is simple, it facilitates the identification of high-risk patients who require aggressive treatment because >10% myocardium ischemic is regarded as a scintigraphic indicator for coronary revascularization.
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical University, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Taishiro
authors.initials: T
authors.lastname: Chikamori
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tomiyama
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Usui
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hida
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tanaka
authors.forename: Katsufumi
authors.initials: K
authors.lastname: Harafuji
authors.forename: Akira
authors.initials: A
authors.lastname: Yamashina
mesh_terms: D000368:Aged; D000842:Ankle / Q000098:blood supply; D001161:Arteriosclerosis / Q000175:diagnosis; D001795:Blood Pressure Determination / Q000379:methods*; D001916:Brachial Artery; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis; D010477:Perfusion; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D017256:Technetium Tc 99m Sestamibi