title: 18F-FDG-avid sites mimicking active disease in pediatric Hodgkin's.
abstract: About 1,700 children in the United States are diagnosed yearly with lymphomas; Hodgkin's disease accounts for approximately half of these cases, or 6% of all childhood cancers. Contemporary therapy allows for the achievement of remission in the majority of cases. The fusion of positron emission tomography (PET) with CT provides the most accurate imaging method for disease characterization and treatment response. However, experience with 18F-FDG PET-CT is limited in pediatric Hodgkin's disease. Numerous non-oncologic processes can mimic recurrent or residual tumor. This pictorial addresses mimickers of disease such as uptake in normal structures, infections, transforming germinal canters and effects of therapy on normal tissues. It is essential for radiologists to be familiar with these findings in order to stage disease activity and therapeutic response accurately.
authors.affiliation: St. Jude Children's Research Hospital, Department of Radiological Sciences, University of Tennessee College of Medicine, 332 N. Lauderdale, Memphis, TN 38105, USA. sue.kaste@stjude.org
authors.forename: Sue C
authors.initials: SC
authors.lastname: Kaste
authors.forename: Scott C
authors.initials: SC
authors.lastname: Howard
authors.forename: Elizabeth B
authors.initials: EB
authors.lastname: McCarville
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Krasin
authors.forename: Philip G
authors.initials: PG
authors.lastname: Kogos
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Hudson
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000378:metabolism; D002648:Child; D003937:Diagnosis, Differential; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D018858:Germinal Center / Q000000981:diagnostic imaging / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D006689:Hodgkin Disease / Q000000981:diagnostic imaging*; D006801:Humans; D007239:Infections / Q000000981:diagnostic imaging / Q000378:metabolism; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D013950:Thymus Gland / Q000000981:diagnostic imaging / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D016179:Granulocyte Colony-Stimulating Factor