Aurantosides G, H, and I: three new tetramic acid glycosides from a Papua New Guinea Theonella swinhoei.
Aurantosides G-I (1-3) have been isolated from the lithistid sponge Theonella swinhoei from Papua New Guinea. Their structures were established by spectroscopic and chemical methods. Compounds 1-3 represent new monochloropentaenoyl tetramic acids with mono-, di-, and tri-N-saccharide substituents, respectively. Aurantosides G-I (1-3) failed to show any significant cytotoxicity against the human colon tumor cell line HCT-116.
Ratnayake
Anokha S
AS
Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Davis
Rohan A
RA
Harper
Mary Kay
MK
Veltri
Charles A
CA
Andjelic
Cynthia D
CD
Barrows
Louis R
LR
Ireland
Chris M
CM
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D011161:Porifera / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006027:Glycosides; D011760:Pyrrolidinones; C498132:aurantoside G; C498134:aurantoside H; C498133:aurantoside I