title: Does the site of insertion of a systemic-pulmonary shunt influence growth of the pulmonary arteries?
abstract: BACKGROUND
  The modified Blalock-Taussig shunt is a common palliative procedure for children with cyanotic congenital heart disease. The distal shunt anastomosis can be done to a branch pulmonary artery or to the main pulmonary artery. The purpose of this study was to determine if the site of shunt connection influences pulmonary artery growth.
  
  
  METHODS
  The records of 101 patients with a modified Blalock-Taussig shunt undergoing a subsequent cardiac catheterization between January 2000 and April 2002 were retrospectively reviewed. From the cineangiograms, the diameters of the right and left pulmonary arteries at their first branching and the diameter of the descending aorta at the diaphragm were measured.
  
  
  RESULTS
  If the distal shunt anastomosis was to the right pulmonary artery and there was no antegrade pulmonary flow then the left pulmonary artery was significantly smaller than if the distal connection was to the main pulmonary artery (p = 0.009). Absence of antegrade pulmonary blood flow resulted in significantly smaller right and left pulmonary artery size in general (p < 0.001). No significant differences in pulmonary artery growth were found with respect to gender, anatomic subtype, proximal shunt site, use of cardiopulmonary bypass or size of shunt. By multiple regression analysis absence of antegrade flow and the presence of right-sided shunts were statistically significant predictors of smaller left pulmonary artery and size discrepancy between right and left pulmonary artery.
  
  
  CONCLUSIONS
  These data suggest that in the absence of antegrade pulmonary blood flow, a modified Blalock-Taussig shunt to the main pulmonary artery may promote more uniform branch pulmonary artery growth.
authors.affiliation: Department of Pediatric Cardiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Anjan S
authors.initials: AS
authors.lastname: Batra
authors.forename: Vaughn A
authors.initials: VA
authors.lastname: Starnes
authors.forename: Winfield J
authors.initials: WJ
authors.lastname: Wells
mesh_terms: D000714:Anastomosis, Surgical / Q000009:adverse effects / Q000706:statistics & numerical data; D006348:Cardiac Surgical Procedures / Q000706:statistics & numerical data*; D002648:Child; D002675:Child, Preschool; D002932:Cineangiography; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging / Q000209:etiology; D003490:Cyanosis / Q000150:complications / Q000517:prevention & control; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010166:Palliative Care / Q000706:statistics & numerical data; D011651:Pulmonary Artery / Q000000981:diagnostic imaging* / Q000254:growth & development*; D012044:Regression Analysis; D012189:Retrospective Studies; D016896:Treatment Outcome