Antidiabetic effect of Boerhavia diffusa: effect on serum and tissue lipids in experimental diabetes.
The present study was designed to investigate the antihyperlipidemic activity of an aqueous extract of Boerhavia diffusa leaves in alloxan diabetic rats. Hyperlipidemia is an associated complication of diabetes mellitus. Many herbs and spices are known to be antihyperglycemic. Oral administration of B. diffusa leaf extract (BLEt) at 200 mg/kg of body weight for 4 weeks resulted in significant reduction in serum and tissue cholesterol, free fatty acids, phospholipids, and triglycerides. Moreover, BLEt supplementation was found to be more effective than glibenclamide in the treatment of diabetic rats.
Pari
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L
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.
Amarnath Satheesh
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D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000209:etiology; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism; D039281:Nyctaginaceae / Q000737:chemistry*; D010743:Phospholipids / Q000097:blood; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D007328:Insulin; D010743:Phospholipids; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol