title: Dementia in idiopathic Parkinson's syndrome.
abstract: Approximately 25% of patients with idiopathic Parkinson's disease (IPD) later develop dementia, with the typical characteristics as detailed in ICD-10 and DSM-IV. Differential diagnosis has to exclude dementia due to Lewy bodies, subcortical vascular encephalopathy and subcortical dementia due to progressive supranuclear paralysis or corticobasal degeneration. Several studies showed promising results for cholinesterase inhibitors such as donepezile, rivastigmine and galantamine. The demented Parkinsonian patients then present with improvement in cognitive function while motor skills do not deteriorate.
authors.affiliation: Parkinson-Clinic Wolfach, Kreuzbergstr. 12-24, 77709 Wolfach, Germany. g.fuchs@parkinson-klinik.de
authors.forename: Gerd A
authors.initials: GA
authors.lastname: Fuchs
authors.forename: Irene
authors.initials: I
authors.lastname: Gemende
authors.forename: Birgit
authors.initials: B
authors.lastname: Herting
authors.forename: Mathias R
authors.initials: MR
authors.lastname: Lemke
authors.forename: Christian
authors.initials: C
authors.lastname: Oehlwein
authors.forename: Heinz
authors.initials: H
authors.lastname: Reichmann
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rieke
authors.forename: David
authors.initials: D
authors.lastname: Emmans
authors.forename: Jens
authors.initials: J
authors.lastname: Volkmann
mesh_terms: D002800:Cholinesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D003704:Dementia / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D003937:Diagnosis, Differential; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis / Q000503:physiopathology; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D002800:Cholinesterase Inhibitors