Omega-3 (n-3) fatty acids in health and disease: Part 1--cardiovascular disease and cancer.
The omega-3 (n-3) polyunsaturated fatty acids have a wide range of beneficial effects in several human health conditions. Animal and in vitro studies have indicated that omega-3 fatty acids affect blood lipid profiles, cardiovascular health, membrane lipid composition, eicosanoid biosynthesis, cell signaling cascades, and gene expression. Findings from epidemiological studies suggest that intake of omega-3 fatty acids from natural sources or supplements may influence the onset and progression of several disease states, including cardiovascular disease and cancer. This review highlights some recent research findings that help advance our understanding of how omega-3 fatty acids influence cardiovascular disease and cancer.
Shahidi
Fereidoon
F
Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada. fshahidi@mun.ca
Miraliakbari
Homan
H
D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000517:prevention & control* / Q000628:therapy; D019587:Dietary Supplements / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000378:metabolism / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000517:prevention & control* / Q000628:therapy
D015525:Fatty Acids, Omega-3