Energy biogenesis: one key for coordinating two genomes.
In metazoan organisms, energy production is the only example of a process that is under dual genetic control: nuclear and mitochondrial. We used a genomic approach to examine how energy genes of both the nuclear and mitochondrial genomes are coordinated, and discovered a novel genetic regulatory circuit in Drosophila melanogaster that is surprisingly simple and parsimonious. This circuit is based on a single DNA regulatory element and can explain both intra- and inter-genomic coordinated expression of genes involved in energy production, including the full complement of mitochondrial and nuclear oxidative phosphorylation genes, and the genes involved in the Krebs cycle.
Sardiello
Marco
M
Dipartimento di Anatomia Patologica e di Genetica, Sezione di Genetica, Università di Bari, via Amendola 165/A, 70126 Bari, Italy.
Tripoli
Gaetano
G
Romito
Antonio
A
Minervini
Crescenzio
C
Viggiano
Luigi
L
Caggese
Corrado
C
Pesole
Graziano
G
D000818:Animals; D000852:Anopheles / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics*; D004734:Energy Metabolism / Q000235:genetics*; D016678:Genome
D004272:DNA, Mitochondrial