[Characteristics of erythropoiesis regulation in population living at high altitude].
OBJECTIVE
To study characteristics of iron deficiency anemia (IDA) in native population of high altitude territories.


METHODS
1300 women living in Tien-Shan areas were examined for serum and erythrocytic ferritins (SF and EF), general iron-binding capacity of the serum, transferrin saturation with iron, transferrin, soluble transferrin receptor (TR), erythropoietin (EP), Hb, erythrocytes, erythrocytic indices.


RESULTS
Regulation of erythropoiesis in women living at high altitude is specific, i.e. disagreement between complete depletion of iron (by SF and EF) and normal level of Hb, erythrocytes, EP and TR.


CONCLUSIONS
It is suggested that in population living at high altitudes (3000 m above the sea level and higher) long-term adaptation to hypoxia gave rise to an original mechanism of erythropoiesis regulation when all coming iron participates in hemoglobin synthesis without iron deposition. Under hypoxic hypoxia regulation of erythropoiesis is directed to prevention of tissue hypoxia.
Makeshova
A B
AB
Levina
A A
AA
Mamukova
Iu I
IuI
Raimzhanov
A R
AR
D000222:Adaptation, Physiological; D000531:Altitude; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000209:etiology; D004909:Erythrocyte Indices / Q000502:physiology; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis / Q000502:physiology*; D004921:Erythropoietin / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000150:complications / Q000503:physiopathology; D007501:Iron / Q000097:blood; D007707:Kyrgyzstan; D011990:Receptors, Transferrin / Q000097:blood; D014168:Transferrin / Q000378:metabolism
D011990:Receptors, Transferrin; D014168:Transferrin; D004921:Erythropoietin; D005293:Ferritins; D007501:Iron