title: Antidiabetic activity of Caesalpinia bonducella F. in chronic type 2 diabetic model in Long-Evans rats and evaluation of insulin secretagogue property of its fractions on isolated islets.
abstract: Caesalpinia bonducella F., is a shrub widely distributed throughout the coastal region of India and is ethnically used by the tribal people of Andaman and Nicober Island as a remedy of symptoms of diabetes mellitus. This ethnic report prompted the detail investigation of hypoglycemic activity of Caesalpinia bonducella seeds, initially on physiological hyperglycemic model and then on type 1 and type 2 sub-acute diabetic animal models which has already been reported. Evaluation of different extracts from Caesalpinia bonducella in chronic type 2 diabetic model alongwith insulin secretagogue activity of five fractions isolated from the Caesalpinia bonducella seed kernel are presented in this paper. Both the aqueous and ethanolic extracts showed potent hypoglycemic activity in chronic type 2 diabetic model. Two fractions BM 169 and BM 170 B could increase secretion of insulin from isolated islets.
authors.affiliation: S. N. Pradhan Centre for Neurosciences, University College of Medicine, 244B, Acharya J.C. Bose Road, Kolkata 700020, India.
authors.forename: Shrabana
authors.initials: S
authors.lastname: Chakrabarti
authors.forename: Tuhin Kanti
authors.initials: TK
authors.lastname: Biswas
authors.forename: Tapan
authors.initials: T
authors.lastname: Seal
authors.forename: Begum
authors.initials: B
authors.lastname: Rokeya
authors.forename: Liaquat
authors.initials: L
authors.lastname: Ali
authors.forename: A K
authors.initials: AK
authors.lastname: Azad Khan
authors.forename: Nilufer
authors.initials: N
authors.lastname: Nahar
authors.forename: M
authors.initials: M
authors.lastname: Mosihuzzaman
authors.forename: Biswapati
authors.initials: B
authors.lastname: Mukherjee
mesh_terms: D000818:Animals; D029911:Caesalpinia; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004195:Disease Models, Animal; D005260:Female; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D020318:Rats, Long-Evans; D012639:Seeds
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts