Secondary supratentorial primitive neuroectodermal tumor following irradiation in a patient with low-grade astrocytoma.
We report a case of a supratentorial primitive neuroectodermal tumor (PNET) that occurred 12 years after cranial irradiation for a grade II astrocytoma. Neuroimaging was unable to distinguish between a recurrence of the original neoplasm and the development of a new, distinct entity. Pathologic review assisted by immunohistochemical staining, however, revealed a high-grade PNET. Although rare, PNET needs to be included in the differential diagnoses for previously irradiated patients, who develop recurrent brain tumors in the presence of uncharacteristic imaging features.
Chen
Allan Y
AY
Department of Radiation Oncology , University of California-Davis Medical Center, Sacramento, CA 95817, USA.
Lee
Haidy
H
Hartman
Jonathan
J
Greco
Claudia
C
Ryu
Janice K
JK
O'Donnell
Robert
R
Boggan
James
J
D000328:Adult; D001254:Astrocytoma / Q000532:radiotherapy*; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy*; D016371:Cranial Irradiation; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000528:radiation effects; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis* / Q000473:pathology; D018714:Radiotherapy, Adjuvant; D015173:Supratentorial Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016708:Synaptophysin / Q000032:analysis; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D016708:Synaptophysin