[Endocrine tumor].
Endocrine tumor occurs in endocrine organs which in general synthesize and secrete hormones. Endocrine tumors produce and secrete hormones produced and secreted in putative tissues and/or cells of origin, or hormones which may be produced and secrete de novo as a result of neoplastic transformation of these cells. Therefore, the analysis of tumor markers in endocrine tumors is usually performed by measuring the levels of these hormones or their precursors and/or metabolites as accurately as possible in serum or urine. The purpose of the analysis may be summarized as follows: 1) early detection of endocrine neoplasms including challenge or loading tests; 2) definitive diagnosis and/or prediction of clinical course and/or prognosis of the patients mainly using immunohistochemistry of the resected specimens: and 3) early detection of recurrence of the tumor through analyzing the serum and/or urinary hormones or their metabolites levels.
Sasano
Hironobu
H
Dept. of Pathology, Tohoku University School of Medicine.
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis; D014408:Biomarkers, Tumor / Q000032:analysis*; D004268:DNA-Binding Proteins / Q000032:analysis*; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D004701:Endocrine Gland Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D018398:Homeodomain Proteins; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D011379:Prognosis; D018160:Receptors, Cytoplasmic and Nuclear; D012008:Recurrence; D054339:Steroidogenic Factor 1; D014157:Transcription Factors / Q000032:analysis*
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D006728:Hormones; D019394:Ki-67 Antigen; D018160:Receptors, Cytoplasmic and Nuclear; D054339:Steroidogenic Factor 1; D014157:Transcription Factors