title: Genetic selection for resistance or susceptibility to oral tolerance to ovalbumin affects general mechanisms of tolerance induction in mice.
abstract: To study the genes involved in oral tolerance susceptibility, two strains of mice were genetically selected for susceptibility (TS) and resistance (TR) to oral tolerance to ovalbumin by bidirectional breeding. Herein we show that the genetic selection process is restricted neither to ovalbumin nor to oral tolerance. It affected oral tolerance to other proteins, such as casein, and tolerance induced the intravenous route.
authors.affiliation: Laboratório de Imunobiologia, Departamento de Bioquímica e Imunologia, ICB-UFMG, Av. Antônio Carlos, 6627 Pampulha, Belo Horizonte-MG Brazil.
authors.forename: Alice O
authors.initials: AO
authors.lastname: Kamphorst
authors.forename: Maria F S
authors.initials: MF
authors.lastname: da Silva
authors.forename: Antônio C
authors.initials: AC
authors.lastname: da Silva
authors.forename: Claudia R
authors.initials: CR
authors.lastname: Carvalho
authors.forename: Ana Maria C
authors.initials: AM
authors.lastname: Faria
mesh_terms: D000818:Animals; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D007108:Immune Tolerance; D007113:Immunity, Innate / Q000235:genetics*; D008297:Male; D051379:Mice; D010047:Ovalbumin / Q000276:immunology* / Q000494:pharmacology; D012641:Selection, Genetic
chemical_list: D010047:Ovalbumin