SAGA unveiled.
Transcriptional regulation in eukaryotes is intimately coupled to chromatin dynamics. The SAGA (Spt-Ada-Gcn5) histone acetyltransferase (HAT) complex of Saccharomyces cerevisiae is a multi-subunit co-factor for RNA polymerase II transcription. However, not all gene activation events require its intrinsic HAT activity. In addition, SAGA subunits can also restrict gene transcription. The recently published structural model from the laboratories of Fred Winston and Patrick Schultz of the SAGA complex provides a framework to rationalize these findings and to direct further investigation of this crucial transcriptional co-factor.
Timmers
H Th Marc
HT
Laboratory for Physiological Chemistry, University Medical Centre-Utrecht, STR. 3.223, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Tora
Làszlò
L
D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D002843:Chromatin / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D051548:Histone Acetyltransferases; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism*; D020836:Protein Structure, Quaternary; D012319:RNA Polymerase II / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology; D015533:Transcriptional Activation
D002843:Chromatin; D046912:Multiprotein Complexes; D029701:Saccharomyces cerevisiae Proteins; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D012319:RNA Polymerase II