title: Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects.
abstract: Elevated levels of serum amyloid A (SAA) and C-reactive protein (CRP) have been associated with increased cardiovascular risk. Although levels of CRP decrease with weight loss, it is not known whether SAA decreases with weight loss or whether dietary macronutrient composition affects levels of either SAA or CRP. SAA and CRP levels were measured retrospectively on baseline and 3-month plasma samples from 41 obese (mean body mass index 33.63 +/- 1.86 kg/m2) women completing a randomized trial comparing a low-fat diet (n = 19) and a very low-carbohydrate diet (n = 22). For the 41 participants, there were significant decreases from baseline to 3 months in both LogSAA (P = 0.049) and LogCRP (P = 0.035). The very low-carbohydrate dieters had a significantly greater decrease in LogSAA (P = 0.04), but their weight loss also was significantly greater (-7.6 +/- 3.2 vs. -4.3 +/- 3.5 kg, P < 0.01). In this study, the decreases in inflammatory markers correlated significantly with weight loss (r = 0.44, P = 0.004 vs. LogSAA and r = 0.35, P = 0.03 vs. LogCRP). Also, change in LogSAA correlated with change in insulin resistance (r = 0.35, P = 0.03). Thus, in otherwise healthy, obese women, weight loss was associated with significant decreases in both SAA and CRP. These effects were proportional to the amount of weight lost but independent of dietary macronutrient composition.
authors.affiliation: Department of Medicine, Division of Cardiology, Box 356422, University of Washington, 1959 Northeast Pacific Street, Seattle, Washington 98195-6422, USA. cardiac@u.washington.edu
authors.forename: Kevin D
authors.initials: KD
authors.lastname: O'Brien
authors.forename: Bonnie J
authors.initials: BJ
authors.lastname: Brehm
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Seeley
authors.forename: Judy
authors.initials: J
authors.lastname: Bean
authors.forename: Mark H
authors.initials: MH
authors.lastname: Wener
authors.forename: Stephen
authors.initials: S
authors.lastname: Daniels
authors.forename: David A
authors.initials: DA
authors.lastname: D'Alessio
mesh_terms: D001794:Blood Pressure; D002097:C-Reactive Protein / Q000032:analysis*; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000178:diet therapy; D000685:Serum Amyloid A Protein / Q000032:analysis*; D015431:Weight Loss
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D008055:Lipids; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein