Growth factor-induced therapeutic angiogenesis in the heart: protein therapy.
Therapeutic angiogenesis, stimulated growth of new vasculature to compensate for tissue ischemia, remains an unfulfilled promise. After nearly a decade of trials, the development of drugs capable of stimulating revascularization of underperfused tissues remains an exciting but unrealized goal in cardiovascular therapeutics. This review will summarize experiences in therapeutic angiogenesis studies employing protein therapies and will draw conclusions based on our current understanding of biological processes of new vessel growth.
Annex
Brian H
BH
Division of Cardiology, Department of Medicine, Durham Veterans Administration, Duke University Medical Center, Durham, NC, USA. annex001@mc.duke.edu
Simons
Michael
M
D000328:Adult; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003326:Coronary Circulation / Q000187:drug effects; D006801:Humans; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D009204:Myocardial Revascularization / Q000379:methods*; D018919:Neovascularization, Physiologic / Q000187:drug effects*
D043925:Angiogenesis Inducing Agents