title: Fractional flow reserve for the prediction of cardiac events after coronary stent implantation: results of a multivariate analysis.
abstract: OBJECTIVE
  To determine the prognostic value of fractional flow reserve (FFR) measurements after coronary stent implantation including multiple clinical and angiographic parameters collected in one centre.
  
  
  METHODS
  119 consecutive patients were enrolled who had a stent implanted with the use of a pressure wire as a guidewire. Patients were followed up for at least six months. Any death, myocardial infarction, and target vessel revascularisation were considered major adverse cardiac events (MACE). Multivariate logistic regression was used to determine adjusted odds ratios (OR) and 95% confidence intervals (CI) for FFR and covariates.
  
  
  RESULTS
  Complete follow up data were available for all 119 patients. Pre-interventional FFR increased from 0.65 (0.15) to 0.94 (0.06) (p < 0.0001) after stent implantation. Eighteen MACE (15%) occurred during follow up including 15 (12.6%) target vessel revascularisations. Final FFR was significantly higher in patients without than in patients with an event (0.95 (0.05) v 0.88 (0.08), p = 0.001). In the multivariate logistic regression analysis, only final FFR < 0.95 (OR 6.22, 95% CI 1.79 to 21.62, p = 0.004) and reduced left ventricular function (OR 0.95, 95% CI 092 to 0.99, p = 0.021) remained as significant independent predictors for MACE.
  
  
  CONCLUSIONS
  These results including multiple parameters underline that FFR after coronary stenting is a strong and independent predictor for subsequent cardiac events after six months' follow up.
authors.affiliation: Department of Cardiology, Medizinische Poliklinik-Innenstadt, University of Munich, Ziemssenstrasse 1, D-80336 Munich, Germany. klauss@medinn.med.uni-muenchen.de
authors.forename: V
authors.initials: V
authors.lastname: Klauss
authors.forename: P
authors.initials: P
authors.lastname: Erdin
authors.forename: J
authors.initials: J
authors.lastname: Rieber
authors.forename: M
authors.initials: M
authors.lastname: Leibig
authors.forename: H-U
authors.initials: HU
authors.lastname: Stempfle
authors.forename: A
authors.initials: A
authors.lastname: König
authors.forename: M
authors.initials: M
authors.lastname: Baylacher
authors.forename: K
authors.initials: K
authors.lastname: Theisen
authors.forename: M C
authors.initials: MC
authors.lastname: Haufe
authors.forename: G
authors.initials: G
authors.lastname: Sroczynski
authors.forename: T
authors.initials: T
authors.lastname: Schiele
authors.forename: U
authors.initials: U
authors.lastname: Siebert
mesh_terms: D017023:Coronary Angiography / Q000379:methods; D003326:Coronary Circulation; D023903:Coronary Restenosis / Q000503:physiopathology / Q000517:prevention & control; D023921:Coronary Stenosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009204:Myocardial Revascularization / Q000379:methods*; D012086:Reoperation; D015607:Stents; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000209:etiology