title: Active site directed inhibitors of replication-specific bacterial DNA polymerases.
abstract: 7-Substituted-N(2)-(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram(+) bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram(-) bacteria.
authors.affiliation: GLSynthesis Inc., One Innovation Drive, Worcester, MA 01605, USA. george.wright@glsynthesis.com
authors.forename: George E
authors.initials: GE
authors.lastname: Wright
authors.forename: Neal C
authors.initials: NC
authors.lastname: Brown
authors.forename: Wei-Chu
authors.initials: WC
authors.lastname: Xu
authors.forename: Zheng-Yu
authors.initials: ZY
authors.lastname: Long
authors.forename: Chengxin
authors.initials: C
authors.lastname: Zhi
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Gambino
authors.forename: Marjorie H
authors.initials: MH
authors.lastname: Barnes
authors.forename: Michelle M
authors.initials: MM
authors.lastname: Butler
mesh_terms: D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D001665:Binding Sites; D001667:Binding, Competitive; D004258:DNA Polymerase III / Q000037:antagonists & inhibitors; D004261:DNA Replication / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000201:enzymology; D006094:Gram-Positive Bacteria / Q000201:enzymology; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D019384:Nucleic Acid Synthesis Inhibitors; D013329:Structure-Activity Relationship; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D019384:Nucleic Acid Synthesis Inhibitors; D014498:Uracil; D006147:Guanine; D004258:DNA Polymerase III