title: Rhabdomyolysis after simvastatin therapy in an HIV-infected patient with chronic renal failure.
abstract: We encountered a 49-year-old HIV-infected man with chronic renal insufficiency who developed rhabdomyolysis after treatment with simvastatin. He recovered after initiating hemodialysis and discontinuing oral medications. Rhabdomyolysis most likely resulted from an excessive blood concentration of simvastatin caused by concomitant use of fluconazole in the presence of renal insufficiency.
authors.affiliation: Division of Infection Control and Prevention, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Medical School, Niigata, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moro
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tsukada
authors.forename: Atsuto
authors.initials: A
authors.lastname: Tanuma
authors.forename: Arimasa
authors.initials: A
authors.lastname: Shirasaki
authors.forename: Noriaki
authors.initials: N
authors.lastname: Iino
authors.forename: Takeaki
authors.initials: T
authors.lastname: Nishibori
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nishi
authors.forename: Fumitake
authors.initials: F
authors.lastname: Gejyo
mesh_terms: D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000009:adverse effects*; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000188:drug therapy* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012206:Rhabdomyolysis / Q000139:chemically induced*; D019821:Simvastatin / Q000009:adverse effects*
chemical_list: D000924:Anticholesteremic Agents; D019821:Simvastatin