title: Free radical lipid oxidation in brain cortex neurons and neuroglia during convulsions.
abstract: The amount of lipid peroxidation products (conjugated dienes and trienes and Schiff bases) in cortical neurons of the cerebral hemispheres decreased by 30% at the peak of convulsions observed 10-15 min after intraperitoneal injection of picrotoxin. In neuroglial cells of control animals the intensity of lipid peroxidation in was 1.7-2.0 times lower. Picrotoxin had no effect on this parameter.
authors.affiliation: Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
authors.forename: M A
authors.initials: MA
authors.lastname: Flerov
authors.forename: T I
authors.initials: TI
authors.lastname: Tolstukhina
authors.forename: I A
authors.initials: IA
authors.lastname: Gerasimova
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003292:Convulsants / Q000633:toxicity; D005609:Free Radicals / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010852:Picrotoxin / Q000633:toxicity; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
chemical_list: D003292:Convulsants; D005609:Free Radicals; D010852:Picrotoxin