RAD51, genomic stability, and tumorigenesis.
Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter recombination pathways to contribute to the chromosomal rearrangements found in these cells. In addition, Rad51 participates in a complex network of interactions that includes DNA damage sensors, tumor suppressors, and cell cycle and apoptotic regulators, and mutation of many of these proteins have also been associated with tumor initiation or progression. Insights into the connection between disregulated Rad51 and malignant phenotype indicate that Rad51 is a potential target for new anti-cancer regimens including those that use siRNA technology.
Richardson
Christine
C
Department of Pathology, Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Ave., New York, NY 10032, USA. car10@columbia.edu
D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins; D019313:BRCA1 Protein / Q000502:physiology; D024682:BRCA2 Protein / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000502:physiology; D004843:Epistasis, Genetic; D020022:Genetic Predisposition to Disease; D042822:Genomic Instability; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D011110:Polymorphism, Genetic; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D051135:Rad51 Recombinase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D011995:Recombination, Genetic; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000502:physiology
D019313:BRCA1 Protein; D024682:BRCA2 Protein; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases; D051135:Rad51 Recombinase