title: Direct asymmetric aldol reactions catalyzed by (4R)-4-(beta-Naphthalenyl)methoxy-(S)-proline.
abstract: A novel proline derivative, (4R)-4-(beta-Naphthalenyl)methoxy-(S)-proline, was conveniently prepared from the naturally occurring (4S)-hydroxy-(S)-proline; 5 mol % of this compound efficiently catalyzes the asymmetric aldol reactions of various benzaldehydes with acetone in excess of acetone as the solvent, giving the aldol adducts in good yields with ee up to 89.8%.
authors.affiliation: Key Laboratory of Organic Synthesis Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, 1 Shizi Street, Suzhou 215006, PR China.
authors.forename: Zongxuan
authors.initials: Z
authors.lastname: Shen
authors.forename: Wuhong
authors.initials: W
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Luo
authors.forename: Yawen
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000096:Acetone; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: C514364:4-(beta-naphthalenyl)methoxyproline; D000447:Aldehydes; D009281:Naphthalenes; D000096:Acetone; C116609:3-hydroxybutanal; D011392:Proline