title: Pyroglutamyl-asparagine amide normalizes long-term potentiation in rat hippocampal slices.
abstract: Preapplication of peptide piracetam analogue pyroglutamyl-asparagine amide to rat hippocampal slices facilitates long-term potentiation of focal responses in the CA1 field after weak tetanization of the synaptic input (30 pulses, 100 Hz). This treatment normalized the development of long-term potentiation after standard tetanization (100 pulses, 100 Hz) impaired by ethanol.
authors.affiliation: Institute of Brain Research, Russian Academy of Medical Sciences, Moscow.
authors.forename: N A
authors.initials: NA
authors.lastname: Kapai
authors.forename: A N
authors.initials: AN
authors.lastname: Chepkova
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: A A
authors.initials: AA
authors.lastname: Morozova
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitskii
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology*; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004151:Dipeptides; D018697:Nootropic Agents; D010446:Peptide Fragments; C081772:pyroglutamyl-asparaginamide; D001127:Arginine Vasopressin; C045881:argipressin (4-9); D011761:Pyrrolidonecarboxylic Acid