Disorders in restructuring of T-cell receptor gamma-chain in malignant skin lymphomas.
Disorders in restructuring of T-cell receptor gamma-chain in DNA from skin biopsy specimens and peripheral blood lymphocyte of patients with malignant skin lymphomas at different stages of the disease were detected by PCR. Nucleotide sequences of monoclonal T-cell receptors were determined. The study showed that DNA sequences from the skin and lymphocytes did not coincide in some cases.
Savvateeva
M V
MV
State Central Institute of Skin and Sexually Transmitted Diseases, Ministry of Health of Russian Federation, Moscow.
Savina
M I
MI
Markusheva
L I
LI
Samsonov
V A
VA
Toguzov
R T
RT
D000328:Adult; D000368:Aged; D001483:Base Sequence; D004273:DNA, Neoplasm / Q000032:analysis; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry; D008223:Lymphoma / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D012867:Skin / Q000737:chemistry; D012878:Skin Neoplasms / Q000235:genetics* / Q000276:immunology* / Q000473:pathology
D004273:DNA, Neoplasm