title: The ScaI gene polymorphism of the atrial natriuretic factor and essential arterial hypertension in childhood.
abstract: In order to investigate the contribution of the atrial natriuretic factor (ANF) gene in pathogenesis of essential arterial hypertension (EAH), we analyzed the ScaI gene polymorphism of the ANF gene in a group of children with EAH. Fifty-eight children, aged 8-19 years, with the diagnosis of EAH were included in the association study and were compared to 57 subjects with normal blood pressure (the control group). Arterial hypertension was defined as systolic/diastolic blood pressure higher than the 95th age-gender-height percentile of the adopted reference values. We failed to demonstrate an association between the ScaI ANF gene polymorphism and EAH in childhood (OR = 2; 95% CI 0.9-4.2; p = 0.07), however, we provided evidence of an interaction between the ScaI ANF gene polymorphism and obesity defined as BMI over the 85th percentile (OR = 13.1; 95% CI 1.6-106; p < 0.001).
authors.affiliation: Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Ruda
authors.initials: R
authors.lastname: Zorc-Plesković
authors.forename: Matjaz
authors.initials: M
authors.lastname: Bidovec
authors.forename: Dejan
authors.initials: D
authors.lastname: Bregar
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Milutinović
authors.forename: Rifet
authors.initials: R
authors.lastname: Terzić
authors.forename: Natasa
authors.initials: N
authors.lastname: Teran
mesh_terms: D000293:Adolescent; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D009320:Atrial Natriuretic Factor