The effect of aspirin and high fibre diet on colorectal carcinoma: a comparative experimental study.
BACKGROUND
The aim of this study is to assess the role of high fibre diet and aspirin on dimethylhydrazine (DMH)-induced colorectal cancer in rats.


METHODS
Colorectal tumours were induced with DMH. The animals were randomly divided into five groups (15 rats each): I, controls; II, rats receiving only the carcinogen; III, rats receiving the carcinogen and high fibre diet; IVA, rats receiving the carcinogen plus low dose aspirin; IVB, rats receiving the carcinogen plus high dose aspirin.


RESULTS
Adenocarcinomas were detected in 100% of the rats in group II, 47% of the rats in group III (chi2, p<0.05), 100% of the rats in group IVA, but the incidence was reduced to 50% in the rats of group IVB (p<0.05).


CONCLUSIONS
These data indicate that high fibre diet and aspirin suppress experimental colon carcinogenesis and the protective effect of aspirin is dose related.
Miliaras
S
S
1st Surgical Department, Aristotle University, Thessaloniki, Greece. smiliara@med.auth.gr
Miliaras
D
D
Vrettou
E
E
Zavitsanakis
A
A
Kiskinis
D
D
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000401:mortality / Q000628:therapy*; D004043:Dietary Fiber / Q000494:pharmacology*; D004127:Dimethylhydrazines; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D009374:Neoplasms, Experimental; D011336:Probability; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D012680:Sensitivity and Specificity; D015996:Survival Rate; D016896:Treatment Outcome
D004043:Dietary Fiber; D004127:Dimethylhydrazines; D001241:Aspirin