Activity of cytochrome P450 in children.
The 6beta-hydroxycortisol/cortisol ratio was measured in 52 children aging 1.1-14.0 years. The maximum increment in this ratio occurred in the age interval of 1.1-2.0 years. During this period, the regression coefficients in the linear (r=0.57; p=0.044) and nonlinear logarithmic models (r=0.56; p=0.049) were similar. At the age of 10-14 years, the examined ratio attained 19.17+/-17.79.
Vavilin
V A
VA
Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. drugmet@soramn.ru
Shchepotina
E G
EG
Manankin
N A
NA
Kaznacheeva
L F
LF
Lyakhovich
V V
VV
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000652:urine; D007223:Infant
C001380:6 beta-hydroxycortisol; D003577:Cytochrome P-450 Enzyme System; D006854:Hydrocortisone