title: Possible involvement of plant ABC transporters in cadmium detoxification: a cDNA sub-microarray approach.
abstract: As a nontolerant plant to a large number of toxic compounds, Arabidopsis thaliana is a suitable model to study regulation of genes involved in response to heavy metals. Using a cDNA-microarray approach, we identified some ABC transporters that are differentially regulated after cadmium treatments, making them putative candidates for being involved in Cd sequestration and redistribution in plants. Regarding yeast and fission yeast, in which Cd is able to form complexes either with glutathione (GSH) or phytochelatins (PC) subsequently transported into vacuoles via ABC transporters, it is also very likely that some plant ABC transporters are able to transport GS(2)-Cd or PC-Cd complexes into subcellular compartments or outside of the cell. The characterization of such transporters is of great interest for developing molecular biology approaches in phytoremediation.
authors.affiliation: IPS, University of BERN, Altenbergrain 21, 3013 BERN, Switzerland. lucien.bovet@ips.unibe.ch
authors.forename: Lucien
authors.initials: L
authors.lastname: Bovet
authors.forename: Urs
authors.initials: U
authors.lastname: Feller
authors.forename: Enrico
authors.initials: E
authors.lastname: Martinoia
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000494:pharmacology*; D017360:Arabidopsis / Q000502:physiology; D001673:Biodegradation, Environmental; D002104:Cadmium / Q000302:isolation & purification / Q000378:metabolism* / Q000633:toxicity*; D020869:Gene Expression Profiling; D020411:Oligonucleotide Array Sequence Analysis; D012989:Soil Pollutants / Q000302:isolation & purification / Q000378:metabolism* / Q000633:toxicity*
chemical_list: D018528:ATP-Binding Cassette Transporters; D012989:Soil Pollutants; D002104:Cadmium