title: Repeatability of non-invasive measurement of intracerebral pulse wave velocity using transcranial Doppler.
abstract: In the present study, the repeatability of three techniques for measuring peripheral PWV (pulse wave velocity) has been studied. A transcranial Doppler provided a wave reading from the middle cerebral artery. Using the transit time between the R-wave of an ECG and the 'foot' of this wave we were able to calculate a PWV (PWV-brain). An ear clip transducer provided a pressure wave reading (PWV-ear). A third pressure reading came from a Finapres transducer on the left middle finger (PWV-finger). The PWV was calculated as distance between two points/transit time of the pulse wave. Eleven volunteers had three sets of readings averaged for each technique taken in two separate sessions. There was good agreement between observers for the mean PWV values, and good agreement for mean results in different sessions. The RC%s (repeatability coefficient percentages) for between-observer repeatability in each session were good and approximately equivalent for PWV-finger (5-7%) and PWV-brain (5-7%). The repeatability of the PWV-ear measurement was less satisfactory (8-18%). The RC% for the same observer between sessions was less good, being 11% for the PWV-finger, 16-17% for PWV-brain and 11-19% for PWV-ear. The RC%s for the inter-session inter-observer measurements were between 10.7-12.1% for the PWV-finger, 14.7-19.5% for PWV-brain and 8.3-15% for PWV-ear. The transit time RC%s were lower in most measurements. The between-observer repeatability of all measures was satisfactory. Owing to the less good repeatability on different occasions, the use of PWV-brain and PWV-ear will depend on the magnitude of differences to be expected.
authors.affiliation: Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Gladdish
authors.forename: Dulka
authors.initials: D
authors.lastname: Manawadu
authors.forename: Winston
authors.initials: W
authors.lastname: Banya
authors.forename: James
authors.initials: J
authors.lastname: Cameron
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Bulpitt
authors.forename: Chakravarthi
authors.initials: C
authors.lastname: Rajkumar
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004431:Ear, External / Q000098:blood supply; D004562:Electrocardiography; D005260:Female; D005385:Fingers / Q000098:blood supply; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000502:physiology; D015588:Observer Variation; D011673:Pulsatile Flow / Q000502:physiology; D015203:Reproducibility of Results; D017585:Ultrasonography, Doppler, Transcranial