title: Determination of chemical agent optical clearing potential using in vitro human skin.
abstract: OBJECTIVE
  Optical clearing is a method that temporarily reduces the optical scattering of biological tissues.
  
  
  METHODS
  To determine the optical clearing potential (OCP) of various chemical agents, we examined the change in reduced scattering coefficients of in vitro human skin after application directly to the dermal side.
  
  
  CONCLUSIONS
  We found that the mean agent OCP did not correlate with refractive index or osmolality. Lipophilic hyperosmotic agents had a mean OCP less than unity, indicating increased optical scattering.
authors.affiliation: Beckman Laser Institute, University of California, Irvine, California 92612, USA. bchoi@laser.bli.uci.edu
authors.forename: Bernard
authors.initials: B
authors.lastname: Choi
authors.forename: Laura
authors.initials: L
authors.lastname: Tsu
authors.forename: Eric
authors.initials: E
authors.lastname: Chen
authors.forename: Teresa S
authors.initials: TS
authors.lastname: Ishak
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Iskandar
authors.forename: Samuel
authors.initials: S
authors.lastname: Chess
authors.forename: J Stuart
authors.initials: JS
authors.lastname: Nelson
mesh_terms: D046508:Culture Techniques; D006801:Humans; D009930:Organic Chemicals / Q000494:pharmacology*; D012016:Reference Values; D012680:Sensitivity and Specificity; D012867:Skin / Q000737:chemistry*; D012869:Skin Absorption / Q000502:physiology*; D012879:Skin Physiological Phenomena; D041623:Tomography, Optical Coherence
chemical_list: D009930:Organic Chemicals