title: Alendronate inhibits bone resorption at the bone-screw interface.
abstract: In the current study, we investigated whether the systemic administration of alendronate, a third-generation bisphosphonate, suppressed the loosening of screws at the bone-screw interface. We systemically administered alendronate to rats fitted with external fixators. External fixators with two half pins were applied to the right femurs of rats, and alendronate was administrated once a week during a 5-week postoperative period. Radiographic, histologic, and immunohistochemical findings subsequently were analyzed. Treatment with alendronate reduced the width of the fibrous loosening membrane and the number of osteoclasts at the bone-screw interface. These findings indicate that systemic treatment with alendronate exerts an inhibitory effect on local bone resorption at the bone-screw interface.
authors.affiliation: Department of Orthopedic Surgery, Osaka University Medical School, Osaka, Japan. miyaji@ort.med.osaka-u.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Miyaji
authors.forename: Takanobu
authors.initials: T
authors.lastname: Nakase
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Azuma
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Shimizu
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Uchiyama
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D000135:Acid Phosphatase / Q000187:drug effects / Q000378:metabolism; D019386:Alendronate / Q000494:pharmacology*; D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy* / Q000378:metabolism; D001863:Bone Screws; D056657:Cathepsin K; D002403:Cathepsins / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D016267:External Fixators; D005269:Femur; D007527:Isoenzymes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011475:Prosthesis Failure; D051381:Rats; D017208:Rats, Wistar; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D007527:Isoenzymes; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D002403:Cathepsins; D056657:Cathepsin K; C534133:Ctsk protein, rat; D019386:Alendronate