Lateral line: precocious phenotypes and planar polarity.
Work on zebrafish mutants that develop supernumerary neuromasts in the lateral line has revealed an inhibitory mechanism, mediated by glial cells, that represses newly identified precursors of secondary neuromasts, ensuring successive waves of neuromast production occur on time. The alignment of hair cells in neuromasts corresponds to the timing of these waves.
Whitfield
Tanya T
TT
Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK.
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D047908:Intracellular Signaling Peptides and Proteins; D008465:Mechanoreceptors / Q000502:physiology*; D009024:Morphogenesis; D009457:Neuroglia / Q000502:physiology; D009474:Neurons / Q000502:physiology; D009687:Nuclear Proteins; D010641:Phenotype; D017027:Protein Tyrosine Phosphatases; D013997:Time Factors; D015534:Trans-Activators / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology*; D029961:Zebrafish Proteins
D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D015534:Trans-Activators; D029961:Zebrafish Proteins; D017027:Protein Tyrosine Phosphatases; C501158:eya1 protein, zebrafish