Skin cancer: lights on genome lesions.
Sunlight generates skin damage mainly by inducing DNA lesions in epidermal cells. The recent development of transgenic mice expressing specific photolyases has identified cyclobutane pyrimidine dimers as the major player in ultraviolet-induced damage, including skin cancer.
Lima-Bessa
Keronninn M
KM
Department of Microbiology, Institute of Biomedical Sciences, São Paulo, SP, Brazil. kmlima@usp.br
Menck
Carlos F M
CF
D000818:Animals; D004249:DNA Damage / Q000528:radiation effects*; D045643:DNA Repair Enzymes / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D016296:Mutagenesis; D011740:Pyrimidine Dimers / Q000378:metabolism*; D012878:Skin Neoplasms / Q000209:etiology* / Q000378:metabolism; D013472:Sunlight; D014466:Ultraviolet Rays
D011740:Pyrimidine Dimers; C058406:pyrimidine-pyrimidone dimer; D045643:DNA Repair Enzymes