[Pharmacological capacities of the prevention of colorectal cancer].
The paper discusses the results of researches and clinical cases of the use of some drugs and diet in the prevention of colorectal cancer (CRC). Particular emphasis is laid on the efficacy and mechanism of antitumor action of aspirin and nonsteroidal antiinflammatory drugs, folic acid, calcium, ursodeoxycholic acid, epidermal growth factor receptor inhibitors, alpha-difluoromethylornitine, selenium. The paper underlines the importance of dietary addition of products containing the high levels of dietary fibers (available in vegetables, fruits, wheat bran, porridges, etc.) and nonhydrogenated unsaturated fats and omega3-fatty acids. To keep to the general routine involving high physical activity, obesity prevention is of great value in the prophylaxis of CRC.
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D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D002118:Calcium / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D004043:Dietary Fiber / Q000627:therapeutic use*; D005247:Feeding Behavior; D005492:Folic Acid / Q000627:therapeutic use*; D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016588:Anticarcinogenic Agents; D004043:Dietary Fiber; D013267:Stilbenes; D005492:Folic Acid; D000077185:Resveratrol; D001241:Aspirin; D002118:Calcium