The role of SMC proteins in the responses to DNA damage.
The SMC proteins form the cores of three protein complexes in eukaryotes, cohesin, condensin and the Smc5-6 complex. Cohesin holds sister chromatids together after DNA replication and is involved in both the repair of double-strand breaks by homologous recombination and the intra-S-phase checkpoint. Condensin assists in the condensation of chromosomes at mitosis and also has a role in checkpoint control pathways. The Smc5-6 complex is involved in a variety of DNA repair and damage response pathways by as yet unknown mechanisms, but is also associated with repair by homologous recombination.
Lehmann
Alan R
AR
Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK. a.r.lehmann@sussex.ac.uk
D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology*; D004249:DNA Damage; D011995:Recombination, Genetic
D002868:Chromosomal Proteins, Non-Histone