title: Relationship between Heberden's nodes and underlying radiographic changes of osteoarthritis.
abstract: OBJECTIVE
  To determine whether clinically determined Heberden's nodes (HN) and Bouchard's nodes (BN) are associated with underlying individual radiographic changes of osteoarthritis (OA).
  
  
  METHODS
  232 index patients with symptomatic large joint and/or hand OA, and 257 of their first degree relatives were included. HN were graded 0-2; BN were scored as present/absent. Joint space narrowing (JSN) and osteophyte (OST) were each scored 0-3 using the OARSI atlas. A weighted kappa test was used to examine intraobserver reproducibility. Odds ratio (OR) was estimated for the relationship between nodes and associated JSN and OST.
  
  
  RESULTS
  The adjusted OR of HN for underlying JSN in the same digit was 1.72 (95% CI 1.47 to 2.02), whereas for OST it was higher at 5.15 (95% CI 4.37 to 6.08). A similar trend was seen with BN and underlying OA, with OST having a higher OR (OR = 2.98, 95% CI 2.55 to 3.47) than JSN (OR = 1.62, 95% CI 1.37 to 1.91).
  
  
  CONCLUSIONS
  There is a positive relationship between HN/BN and underlying radiographic changes of OA, especially OST. Nodes do appear to link pathologically to OA in interphalangeal joints.
authors.affiliation: Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK.
authors.forename: A
authors.initials: A
authors.lastname: Thaper
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Wright
authors.forename: M
authors.initials: M
authors.lastname: Doherty
mesh_terms: D000368:Aged; D000886:Anthropometry; D003430:Cross-Sectional Studies; D005096:Exostoses / Q000150:complications* / Q000473:pathology; D005260:Female; D005384:Finger Joint / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010003:Osteoarthritis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012720:Severity of Illness Index