title: Mitigation of susceptibility-induced signal loss in neuroimaging using localized shim coils.
abstract: Correction of magnetic field distortions is essential for obtaining accurate brain blood-oxygen-level-dependent functional magnetic resonance imaging (fMRI) activation maps. The present work introduces an active shimming method that utilizes the magnetic field generated by resistive shim coils placed in the mouth to locally homogenize the magnetic field in the inferior portion of the frontal lobe, where the field is most seriously distorted. The shimming field can be optimized in situ patient by patient for the region of interest of the scanner operator's choice. The method at 1.5 T is shown to be effective in reducing field inhomogeneity and in recovery of fMRI signal. For example, in a region of interest approximately of 149 cm3, a coil of simple geometry can reduce the root mean square of the magnetic field by more than 50% and the recovered signal increases the extent of activation detected in a breath-holding fMRI experiment.
authors.affiliation: Lucas Magnetic Resonance Spectroscopy and Imaging Center, Stanford University School of Medicine, Stanford, California 94305-5488, USA. jjhsu@stanford.edu
authors.forename: Jung-Jiin
authors.initials: JJ
authors.lastname: Hsu
authors.forename: Gary H
authors.initials: GH
authors.lastname: Glover
mesh_terms: D016477:Artifacts; D001921:Brain / Q000166:cytology / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014159:Transducers