Distinct Leishmania braziliensis isolates induce different paces of chemokine expression patterns.
Inflammatory events during Leishmania braziliensis infection in mice were investigated. Large lesions were directly correlated with the inflammatory reaction but not with parasite burden. Different L. braziliensis strains induce different paces of chemokine expression patterns, leading to diverse cell recruitment and differential inflammatory responses.
Teixeira
Maria Jania
MJ
Centro de Pesquisas Gonçalo Moniz-Fiocruz-BA, 121 Rua Waldemar Falcão, Salvador, Bahia, Brazil 40295-001.
Fernandes
Juliana Dumet
JD
Teixeira
Clarissa Romero
CR
Andrade
Bruno Bezerril
BB
Pompeu
Margarida Lima
ML
Santana da Silva
João
J
Brodskyn
Cláudia Ida
CI
Barral-Netto
Manoel
M
Barral
Aldina
A
D000818:Animals; D018925:Chemokines / Q000096:biosynthesis / Q000235:genetics*; D020869:Gene Expression Profiling; D007700:Kinetics; D007892:Leishmania braziliensis / Q000276:immunology / Q000378:metabolism*; D016773:Leishmaniasis, Cutaneous / Q000276:immunology; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D019707:Receptors, Chemokine / Q000096:biosynthesis / Q000235:genetics
D018925:Chemokines; D012333:RNA, Messenger; D019707:Receptors, Chemokine