title: A modular, one-pot, four-component synthesis of polysubstituted 1,3-oxazolidines.
abstract: A modular, one-pot, two-step, four-component synthesis of polysubstituted 1,3-oxzolidines is described. The method comprises two linked domino processes: an organocatalyzed domino reaction of alkyl propiolate and an aliphatic aldehydes and a microwave-assisted amine addition cyclization domino process. An alternative modular, one-pot, three-step, four-component synthesis has also been developed by linking the organocatalyzed domino process to a sequential amine addition/Yb(OTf)(3)-catalyzed enamine cyclization reaction.
authors.affiliation: Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Islas Canarias, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Tejedor
authors.forename: Alicia
authors.initials: A
authors.lastname: Santos-Expósito
authors.forename: David
authors.initials: D
authors.lastname: González-Cruz
authors.forename: José Juan
authors.initials: JJ
authors.lastname: Marrero-Tellado
authors.forename: Fernando
authors.initials: F
authors.lastname: García-Tellado
mesh_terms: D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry
chemical_list: D010080:Oxazoles; D011355:Prodrugs; C064210:oxazolidine