[Hippocampal serotonin 1A receptor and memory function].
Recent studies have indicated that the serotonergic system plays important roles in memory functions. To clarify this relationship, we examined 5-HT1A receptors using positron emission tomography (PET) with [11C]WAY-100635 and assessed the relationship with memory functions. To interpret the pharmacological implications, we administered the 5-HT1A agonist tandospirone to subjects and investigated the effect of the stimulation of 5-HT1A receptors on cognitive function together with the neuroendocrinological response. There was a significant negative correlation between explicit memory function and 5-HT1A receptor binding localized in the bilateral hippocampus where the postsynaptic 5-HT1A receptors are enriched. Furthermore, we found that the administration of tandospirone dose-dependently impaired explicit verbal memory, while other cognitive functions showed no significant changes. The results show that the postsynaptic 5-HT1A receptors localized in the hippocampal formation have a negative influence on explicit memory function.
Yasuno
Fumihiko
F
Brain Imaging Project, National Institute of Radiological Sciences.
D000328:Adult; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D054833:Isoindoles; D008297:Male; D008568:Memory / Q000502:physiology*; D010879:Piperazines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects / Q000502:physiology*
D054833:Isoindoles; D010879:Piperazines; D011743:Pyrimidines; D044282:Receptor, Serotonin, 5-HT1A; C055267:tandospirone