title: Mixed hepatoblastoma in an adult.
abstract: We report a case in an elderly adult of a highly malignant liver tumor with blastoid features that resembled hepatoblastoma. A liver tumor with a diameter of 23 cm was removed in a 78-year-old woman. The tumor showed highly differentiated epithelial hepatocellular and poorly differentiated epithelial and mesenchymal components. The blastoid nature and pluripotent differentiation potential were supported by immunohistologic analysis and suggest an origin of a poorly differentiated pluripotent hepatic cell with the potential to mature. We believe that this case of a mixed hepatoblastoma in an adult should be added to the growing number of presumed hepatic precursor cell neoplasms in adults.
authors.affiliation: Institute of Pathology, Center for Molecular Medicine, University of Cologne, Cologne, Germany. hans-udo.kasper@uni-koeln.de <hans-udo.kasper@uni-koeln.de>
authors.forename: Hans-Udo
authors.initials: HU
authors.lastname: Kasper
authors.forename: Thomas
authors.initials: T
authors.lastname: Longerich
authors.forename: Dirk L
authors.initials: DL
authors.lastname: Stippel
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kern
authors.forename: Uta
authors.initials: U
authors.lastname: Drebber
authors.forename: Peter
authors.initials: P
authors.lastname: Schirmacher
mesh_terms: D000368:Aged; D005260:Female; D018197:Hepatoblastoma / Q000175:diagnosis*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis*