title: Synthesis, characterization, and plasma lipoprotein association of a nucleus-targeted boronated porphyrin.
abstract: The efficacy of binary cancer therapies such as BNCT and PDT depends critically on the subcellular localization site of the sensitizer. This work presents the synthesis and plasma lipoprotein binding properties of the first reported binary conjugate of a boronated porphyrin with a peptide nuclear localization sequence. The porphyrin-NLS conjugate associates in vitro predominantly with low density lipoproteins. Such association provides a potentially selective entry pathway into malignant cells that overexpress the LDL receptor.
authors.affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94143, USA.
authors.forename: Paola
authors.initials: P
authors.lastname: Dozzo
authors.forename: Myoung-Seo
authors.initials: MS
authors.lastname: Koo
authors.forename: Stephanie
authors.initials: S
authors.lastname: Berger
authors.forename: Trudy M
authors.initials: TM
authors.lastname: Forte
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kahl
mesh_terms: D000952:Antigens, Polyomavirus Transforming / Q000737:chemistry; D001897:Boronic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D010949:Plasma; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011485:Protein Binding; D011973:Receptors, LDL / Q000378:metabolism
chemical_list: D000952:Antigens, Polyomavirus Transforming; D001897:Boronic Acids; D008074:Lipoproteins; D011166:Porphyrins; D011973:Receptors, LDL