title: Formate and its role in hydrogen production in Escherichia coli.
abstract: The production of dihydrogen by Escherichia coli and other members of the Enterobacteriaceae is one of the classic features of mixed-acid fermentation. Synthesis of the multicomponent, membrane-associated FHL (formate hydrogenlyase) enzyme complex, which disproportionates formate into CO(2) and H(2), has an absolute requirement for formate. Formate, therefore, represents a signature molecule in the fermenting E. coli cell and factors that determine formate metabolism control FHL synthesis and consequently dihydrogen evolution.
authors.affiliation: Department of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK. gary.sawers@bbsrc.ac.uk
authors.forename: R G
authors.initials: RG
authors.lastname: Sawers
mesh_terms: D004926:Escherichia coli / Q000378:metabolism*; D005285:Fermentation; D005561:Formates / Q000378:metabolism*; D006859:Hydrogen / Q000378:metabolism*
chemical_list: D005561:Formates; C030544:formic acid; D006859:Hydrogen