title: Macrophage migration inhibitory factor and activator protein-1 in ulcerative colitis.
abstract: Macrophage migration inhibitory factor (MIF) is a cytokine that has potent antisteroid effects. We determined that MIF is involved in the glucocorticoid-resistant inflammatory process of ulcerative colitis (UC), and the altered AP-1 signal is a potent therapeutic target for refractory UC.
authors.affiliation: First Department of Internal medicine, Hirosaki University School of Medicine, 5 zaifu-cho, Hirosaki, Japan. yishi-hki@umin.ac.jp
authors.forename: Yoh
authors.initials: Y
authors.lastname: Ishiguro
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Yamagata
authors.forename: Hirotake
authors.initials: H
authors.lastname: Sakuraba
authors.forename: Akihiro
authors.initials: A
authors.lastname: Munakata
authors.forename: Akio
authors.initials: A
authors.lastname: Nakane
authors.forename: Takayuki
authors.initials: T
authors.lastname: Morita
authors.forename: Jun
authors.initials: J
authors.lastname: Nishihira
mesh_terms: D000818:Animals; D003093:Colitis, Ulcerative / Q000276:immunology* / Q000628:therapy; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology*; D015398:Signal Transduction; D018808:Transcription Factor AP-1 / Q000276:immunology / Q000502:physiology*
chemical_list: D016207:Cytokines; D008263:Macrophage Migration-Inhibitory Factors; D018808:Transcription Factor AP-1