title: Discussions regarding reproductive health for young women with breast cancer undergoing chemotherapy.
abstract: OBJECTIVE
  Young women who undergo chemotherapy for breast cancer face serious consequences to their reproductive health. Research in this area has previously focused on men, or on childhood cancer survivors. We sought to explore self-report of reproductive health counseling in young women undergoing chemotherapy for breast cancer.
  
  
  METHODS
  A total of 166 premenopausal women aged < or = 50 years were recruited from oncology offices in academic and private practices in four northeastern states, as part of a randomized controlled clinical trial aimed at stress reduction. Women were asked a variety of questions regarding diagnosis and treatment, including whether they received any counseling regarding early menopause and fertility issues.
  
  
  RESULTS
  Sixty-eight percent and 34% of women reported recalling a discussion with a physician regarding early menopause or fertility, respectively. In multivariate analysis, hormonal therapy and early stage of disease were associated with significantly increased odds of recall of a discussion regarding menopause. Difficulty communicating with medical team was associated with increased odds of recalling a discussion regarding fertility, whereas older age and anxiety in medical situations were associated with decreased odds.
  
  
  CONCLUSIONS
  Many women fail to recall discussions regarding the reproductive health impact of chemotherapy. Demographic, psychological, and disease-related variables are related to recalling such discussions. Counseling about premature menopause and fertility changes is an overlooked aspect of preparation for adjuvant chemotherapy in young premenopausal women with breast cancer. Future research should explore this issue further.
authors.affiliation: Brown University Medical School, Rhode Island Hospital, RI 02903, USA. Christine_Duffy@Brown.edu
authors.forename: Christine M
authors.initials: CM
authors.lastname: Duffy
authors.forename: Susan M
authors.initials: SM
authors.lastname: Allen
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Clark
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced*; D016015:Logistic Models; D008594:Menopause, Premature / Q000187:drug effects*; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents