title: Mutagenesis of a novel gene in the prcA-prtP protease locus affects expression of Treponema denticola membrane complexes.
abstract: A novel gene was identified in the Treponema denticola prcA-prtP protease operon. Strains with mutations in either the prcA-prtP or the msp region showed altered expression of a product(s) of the other locus. Together, these results provide information on the assembly of outer membrane complexes involved in T. denticola interaction with host cells and tissue.
authors.affiliation: Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA.
authors.forename: Xue-Lin
authors.initials: XL
authors.lastname: Bian
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Ning
authors.forename: Si Young
authors.initials: SY
authors.lastname: Lee
authors.forename: J Christopher
authors.initials: JC
authors.lastname: Fenno
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D002918:Chymotrypsin / Q000235:genetics* / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D010447:Peptide Hydrolases; D018272:Porins / Q000235:genetics* / Q000378:metabolism; D013381:Subtilisins / Q000235:genetics* / Q000378:metabolism; D048373:Treponema denticola / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; D018272:Porins; C102527:PrcA protein, bacteria; C099361:major outer sheath protein, Treponema; D010447:Peptide Hydrolases; D013381:Subtilisins; C102570:dentilisin; D002918:Chymotrypsin