Use of a prediction model for high-order multiple implantation after ovarian stimulation with gonadotropins.
OBJECTIVE
To determine prospectively the effectiveness in clinical practice of a prediction model for high-order multiple pregnancies (HOMP) (triplets or more).


METHODS
Prospective study.


METHODS
University teaching hospital.


METHODS
Eight hundred forty-nine consecutive infertile patients undergoing a total of 1,542 treatment cycles.


METHODS
Gonadotropin ovarian stimulation or induction of ovulation without IVF MAIN OUTCOME MEASURE(S): Observed and predicted overall pregnancy rates and the incidence of HOMP.


RESULTS
The use of the prediction model (implying cancellation of all cycles at high risk for HOMP) would result in an 8% (95% confidence interval, 6.8%-9.2%) reduction of overall pregnancy rate but also in a 285% (95% CI, 279%-291%) reduction of HOMP.


CONCLUSIONS
By using our prediction model, it was possible to maintain a low risk of HOMP with a good pregnancy rate in patients receiving gonadotropin ovarian stimulation or induction of ovulation without IVF.
Tur
Rosa
R
Reproductive Medicine Service, Department of Obstetrics and Gynaecology, Institut Universitari Dexeus, Barcelona, Spain. rostur@dexeus.com
Barri
Pedro N
PN
Coroleu
Buenaventura
B
Buxaderas
Rosario
R
Parera
Núria
N
Balasch
Juan
J
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D010064:Embryo Implantation; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D010062:Ovulation Induction; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011446:Prospective Studies
D006063:Chorionic Gonadotropin; D004958:Estradiol