Biodistribution of carbon single-wall carbon nanotubes in mice.
Carbon nanotubes are promising for use in biomedical and pharmaceutical sciences. Therefore, it becomes imperative to know the basic biological properties of carbon nanotubes in vivo. We labeled the water-soluble hydroxylated carbon single-wall nanotubes with radioactive 125I atoms, and then the tracer was used to study the distribution of hydroxylated carbon single-wall nanotubes in mice. They moved easily among the compartments and tissues of the body, behaving as small active molecules though their apparent mean molecular weight is tremendously large. This study, for the first time, affords a quantitative analysis of carbon nanotubes accumulated in animal tissues.
Wang
Haifang
H
Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Wang
Jing
J
Deng
Xiaoyong
X
Sun
Hongfang
H
Shi
Zujin
Z
Gu
Zhennan
Z
Liu
Yuanfang
Y
Zhao
Yuliang
Y
D000818:Animals; D005243:Feces / Q000737:chemistry*; D007274:Injections, Intraperitoneal; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D037742:Nanotubes, Carbon / Q000032:analysis* / Q000737:chemistry* / Q000648:ultrastructure; D009928:Organ Specificity; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D037742:Nanotubes, Carbon; D019275:Radiopharmaceuticals