The addition of sp2- and sp-hybridized nucleophiles to a bridgehead bromoketone.
The reaction of various sp2- and sp-hybridized organolithium species with bromoketone 1 is presented. In most cases, control over the course of the process is possible and products from simple addition, addition followed by a quasi-Favorskii rearrangement or addition, rearrangement, and addition can be selectively prepared.
Harmata
Michael
M
Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA. harmatam@missouri.edu
Wacharasindhu
Sumrit
S