Plasmonics-based nanostructures for surface-enhanced Raman scattering bioanalysis.
Surface-enhanced Raman scattering (SERS) spectroscopy is a plasmonics-based spectroscopic technique that combines modern laser spectroscopy with unique optical properties of metallic nanostructures, resulting in strongly increased Raman signals when molecules are adsorbed on or near nanometer-size structures of special metals such as gold, silver, and transition metals. This chapter provides a synopsis of the development and application of SERS-active metallic nanostructures, especially for the analysis of biologically relevant compounds. Some highlights of this chapter include reports of SERS as an immunoassay readout method, SERS gene nanoprobes, near-field scanning optical microscopy SERS probes, SERS as a tool for single-molecule detection, and SERS nanoprobes for cellular studies.
Vo-Dinh
Tuan
T
Center for Advanced Biomedical Photonics, Life Sciences Division, Oak Ridge National Laboratory, TN, USA.
Yan
Fei
F
Stokes
David L
DL
D004247:DNA / Q000032:analysis; D015342:DNA Probes; D007118:Immunoassay / Q000379:methods; D049329:Nanostructures; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods
D015342:DNA Probes; D004247:DNA