[A case of eosinophilic cellulitis (Wells' syndrome)].
A 67-year-old man sustained a minor injury on the right hand after touching a potted plant. Several days later, he noted erythema and marked swelling on the right hand and forearm. The same lesions developed on the left hand and forearm. He also had pruritic erythema on the neck, trunk, and thighs. The initial clinical diagnosis was bacterial cellulitis and contact dermatitis. However, oral antibiotic and topical steroid therapy were not effective. Laboratory investigations revealed peripheral blood eosinophilia, elevated serum IgE level, and positive antinuclear antibody. Histopathological examination of a skin biopsy specimen showed an excessive infiltration of eosinophils and flame figures in the dermis. We diagnosed this case as eosinophilic cellulitis (Wells' syndrome). The skin lesions responded rapidly to the systemic oral steroid therapy. There has been no recurrence of eruption in 1 year of follow-up. The condition of the disease was correlated to peripheral blood eosinophil counts, and serum eosinophil cationic protein levels. However, serum interleukin-5 levels were within normal limits.
Shodo
Makoto
M
Department of Dermatology, Toyama Rosai Hospital.
Mizuhashi
Keiichi
K
Kimura
Tetsunori
T
D000368:Aged; D002481:Cellulitis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D047150:Eosinophil Cationic Protein / Q000097:blood; D004802:Eosinophilia / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D012867:Skin / Q000473:pathology
D007073:Immunoglobulin E; D047150:Eosinophil Cationic Protein