title: Synthesis and antiviral effect against herpes simplex type 1 of 12-substituted benzo[c]phenanthridinium salts.
abstract: The synthesis of benzo[c]phenanthridine alkaloid derivatives is described. In vitro antiviral activity against herpes simplex type 1 (HSV1) has been investigated. Contrary to the natural product fagaronine, which did not have any activity in the HSV1 antiviral tests, four 12-alkoxy derivatives showed good activity demonstrating the importance of the 12-substitution in the structure-activity relationships.
authors.affiliation: Laboratoire SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 49100 Angers, France.
authors.forename: Enguerran
authors.initials: E
authors.lastname: Vanquelef
authors.forename: Maryvonne
authors.initials: M
authors.lastname: Amoros
authors.forename: Joel
authors.initials: J
authors.lastname: Boustie
authors.forename: Michael A
authors.initials: MA
authors.lastname: Lynch
authors.forename: Roger D
authors.initials: RD
authors.lastname: Waigh
authors.forename: Olivier
authors.initials: O
authors.lastname: Duval
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D010617:Phenanthridines