title: Secondary supratentorial primitive neuroectodermal tumor following irradiation in a patient with low-grade astrocytoma.
abstract: We report a case of a supratentorial primitive neuroectodermal tumor (PNET) that occurred 12 years after cranial irradiation for a grade II astrocytoma. Neuroimaging was unable to distinguish between a recurrence of the original neoplasm and the development of a new, distinct entity. Pathologic review assisted by immunohistochemical staining, however, revealed a high-grade PNET. Although rare, PNET needs to be included in the differential diagnoses for previously irradiated patients, who develop recurrent brain tumors in the presence of uncharacteristic imaging features.
authors.affiliation: Department of Radiation Oncology , University of California-Davis Medical Center, Sacramento, CA 95817, USA.
authors.forename: Allan Y
authors.initials: AY
authors.lastname: Chen
authors.forename: Haidy
authors.initials: H
authors.lastname: Lee
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hartman
authors.forename: Claudia
authors.initials: C
authors.lastname: Greco
authors.forename: Janice K
authors.initials: JK
authors.lastname: Ryu
authors.forename: Robert
authors.initials: R
authors.lastname: O'Donnell
authors.forename: James
authors.initials: J
authors.lastname: Boggan
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000532:radiotherapy*; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy*; D016371:Cranial Irradiation; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000528:radiation effects; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis* / Q000473:pathology; D018714:Radiotherapy, Adjuvant; D015173:Supratentorial Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016708:Synaptophysin / Q000032:analysis; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D016708:Synaptophysin