The growing importance of fat in regenerative medicine.
A recent publication by Michael Longaker and colleagues represents a landmark for the use of adipose tissue as a source of cells for tissue regeneration. The authors investigated the ability of adipose tissue-derived cells (ADCs) to regenerate critical size calvarial (superior portion of the skull) defects in mice by using a novel osteoconducive apatite-coated Poly-lactic-co-glycolic acid (PLGA) scaffold for cell delivery. Direct comparison of this osteogenic ability was performed with bone marrow stromal cells and juvenile calvarial-derived osteoblasts.
Strem
Brian M
BM
Macropore Biosurgery Inc., 6740 Top Gun Street, San Diego, California 92121, USA. bstrem@macropore.com <bstrem@macropore.com>
Hedrick
Marc H
MH
D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D019344:Lactic Acid; D051379:Mice; D010012:Osteogenesis; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D044968:Regenerative Medicine / Q000639:trends*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*
D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid