Calmodulin methionine residues are targets for one-electron oxidation by hydroxyl radicals: formation of S[therefore]N three-electron bonded radical complexes.
The one-electron oxidation of calmodulin, studied on the microsecond timescale by pulse radiolysis, leads to methionine sulfide radical cations, which complex to adjacent amide groups to form three-electron bonded intermediates.
Nauser
Thomas
T
Laboratory of Inorganic Chemistry, ETH Zürich, CH-8093 Zürich, Switzerland.
Jacoby
Michael
M
Koppenol
Willem H
WH
Squier
Thomas C
TC
Schöneich
Christian
C
D002147:Calmodulin / Q000737:chemistry*; D004583:Electrons; D017665:Hydroxyl Radical / Q000737:chemistry*; D008715:Methionine / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D017434:Protein Structure, Tertiary
D002147:Calmodulin; D017665:Hydroxyl Radical; D008715:Methionine