title: Non-peptidic small molecule inhibitors of XIAP.
abstract: Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead.
authors.affiliation: Cancer Research, Global Pharmaceutical R and D, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064-6010, USA. cheol-min.park@abbott.com
authors.forename: Cheol-Min
authors.initials: CM
authors.lastname: Park
authors.forename: Chaohong
authors.initials: C
authors.lastname: Sun
authors.forename: Edward T
authors.initials: ET
authors.lastname: Olejniczak
authors.forename: Alan E
authors.initials: AE
authors.lastname: Wilson
authors.forename: Robert P
authors.initials: RP
authors.lastname: Meadows
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Betz
authors.forename: Steven W
authors.initials: SW
authors.lastname: Elmore
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Fesik
mesh_terms: D001665:Binding Sites; D015195:Drug Design; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D011506:Proteins / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D051636:X-Linked Inhibitor of Apoptosis Protein
chemical_list: D006571:Heterocyclic Compounds; D007093:Imidazoles; D008024:Ligands; D011506:Proteins; D013844:Thiazoles; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human