title: Clinical value of 99mTc-HMPAO SPECT in depressed bipolar I patients.
abstract: Regional cerebral blood flow was studied in 17 bipolar I depressed patients (DSM-IV criteria) with single photon emission computed tomography (SPECT). Visual analysis of images revealed no abnormality in eight patients and abnormal findings in nine patients. In the nine patients with abnormal findings, all showed regional decreases of the uptake of (99m)Tc-D,L-hexamethylpropylene amine oxime (HMPAO, four in the frontal region, two in the basal ganglia, and three in both the frontal region and the basal ganglia). The patients with visible SPECT abnormalities had significantly higher scores on the Hamilton Rating Scale for Depression (HDRS).
authors.affiliation: Institut Clínic de Psiquiatria i Psicologia, Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, C/Villarroel 170, 08036 Barcelona, Spain. 31555abh@comb.es
authors.forename: Antoni
authors.initials: A
authors.lastname: Benabarre
authors.forename: Eduard
authors.initials: E
authors.lastname: Vieta
authors.forename: Francisco
authors.initials: F
authors.lastname: Martín
authors.forename: Francisco
authors.initials: F
authors.lastname: Lomeña
authors.forename: Anabel
authors.initials: A
authors.lastname: Martínez-Aràn
authors.forename: Francesc
authors.initials: F
authors.lastname: Colom
authors.forename: Barbara
authors.initials: B
authors.lastname: Corbella
authors.forename: Cristóbal
authors.initials: C
authors.lastname: Gastó
authors.forename: Manuel
authors.initials: M
authors.lastname: Valdés
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000098:blood supply; D001714:Bipolar Disorder / Q000175:diagnosis*; D001921:Brain / Q000098:blood supply*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime