Cytotoxic hydroxylated triterpene alcohol ferulates from rice bran.
Three hydroxylated triterpene alcohol ferulates, (24S)-cycloart-25-ene-3 beta,24-diol-3 beta-trans-ferulate (1), (24R)-cycloart-25-ene-3 beta,24-diol-3 beta-trans-ferulate (2), and cycloart-23Z-ene-3 beta,25-diol-3 beta-trans-ferulate (3), along with known compounds cycloartenol trans-ferulate (4) and 24-methylenecycloartanol trans-ferulate (5) were isolated from rice bran. Their structures were elucidated by means of chemical and spectroscopic analysis. Compounds 2-5 showed moderate cytotoxicity against MCF-7 cells.
Luo
Hong-Feng
HF
Arkansas Children's Nutrition Center, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA.
Li
Qinglin
Q
Yu
Shanggong
S
Badger
Thomas M
TM
Fang
Nianbai
N
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001131:Arkansas; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012275:Oryza / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C497961:(24S)-cycloart-25-ene-3 beta,24-diol-3 beta-trans-ferulate; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C497962:cycloart-23Z-ene-3 beta,25-diol-3 beta-trans-ferulate