title: Resistance to dual nucleoside reverse-transcriptase inhibitors in children infected with HIV clade A/E.
abstract: The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothymidine was universal.
authors.affiliation: Queen Sirikit National Institute of Child Health.
authors.forename: Rangsima
authors.initials: R
authors.lastname: Lolekha
authors.forename: Sunee
authors.initials: S
authors.lastname: Sirivichayakul
authors.forename: Umaporn
authors.initials: U
authors.lastname: Siangphoe
authors.forename: Chitsanu
authors.initials: C
authors.lastname: Pancharoen
authors.forename: Suchada
authors.initials: S
authors.lastname: Kaewchana
authors.forename: Wichitra
authors.initials: W
authors.lastname: Apateerapong
authors.forename: Apicha
authors.initials: A
authors.lastname: Mahanontharit
authors.forename: Tawee
authors.initials: T
authors.lastname: Chotpitayasunondh
authors.forename: Kiat
authors.initials: K
authors.lastname: Ruxrungtham
authors.forename: Praphan
authors.initials: P
authors.lastname: Phanuphak
authors.forename: Jintanat
authors.initials: J
authors.lastname: Ananworanich
mesh_terms: D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D024921:Drug Resistance, Multiple, Viral / Q000187:drug effects; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D006801:Humans; D008297:Male; D009154:Mutation; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D018894:Reverse Transcriptase Inhibitors