title: Mitomycin C prevents strictures in caustic esophageal burns in rats.
abstract: BACKGROUND
  Caustic esophageal injuries lead to stricture formation. Although a number of agents have been tried experimentally to prevent strictures, few have gained clinical application. The purpose of this study was to investigate the effectiveness of Mitomycin C (MMC), which inhibits fibroblastic proliferation in preventing caustic esophageal strictures.
  
  
  METHODS
  Fifty-six rats were allocated into four groups. Caustic esophageal burns were created as described by Gehanno. Group A was instilled only with saline. Group B was injured and untreated. Groups C and D were injured and received topical MMC at 0.02 and 0.04% concentrations, respectively. At 28 days, stenosis index (SI), collagen deposition, and hydroxyproline content (HP) were determined in distal esophageal segments. Statistical analyses were done.
  
  
  RESULTS
  Mean SI in Group B was significantly higher than others (P < 0.05). Mean SI was statistically higher in Group C than A and D and similar between groups A and D. The greatest accumulation of collagen was found in Group B, followed by Group C, D, and A, respectively. Collagen deposition in Group D was statistically lower than Group B (P < 0.01) and similar to Group C. Mean HP in Group B was statistically higher than others (P < 0.05), significantly higher in Group C than Group D (P = 0.047), and similar between Groups A and D (P = 0.73).
  
  
  CONCLUSIONS
  MMC was effective in preventing strictures following experimental caustic esophageal injury, in a dose-dependent manner. We consider that it can gain clinical utilization with the establishment of effective mode, dose, and timing of therapy.
authors.affiliation: Department of Pediatric Surgery, Gazi University Faculty of Medicine, Ankara, Turkey. zafertrk@yahoo.com
authors.forename: Zafer
authors.initials: Z
authors.lastname: Türkyilmaz
authors.forename: Kaan
authors.initials: K
authors.lastname: Sönmez
authors.forename: Arzu
authors.initials: A
authors.lastname: Demirtola
authors.forename: Ramazan
authors.initials: R
authors.lastname: Karabulut
authors.forename: Aylar
authors.initials: A
authors.lastname: Poyraz
authors.forename: Sebnem
authors.initials: S
authors.lastname: Gülen
authors.forename: Sibel
authors.initials: S
authors.lastname: Dinçer
authors.forename: A Can
authors.initials: AC
authors.lastname: Başaklar
authors.forename: Nuri
authors.initials: N
authors.lastname: Kale
mesh_terms: D000468:Alkalies / Q000506:poisoning; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001835:Body Weight; D002057:Burns, Chemical / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004940:Esophageal Stenosis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*; D004947:Esophagus / Q000378:metabolism / Q000473:pathology; D006909:Hydroxyproline / Q000378:metabolism; D016685:Mitomycin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000468:Alkalies; D000903:Antibiotics, Antineoplastic; D016685:Mitomycin; D006909:Hydroxyproline