Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS).
Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neuroinflammatory disease of spinal cord motor neurons of unclear etiology. Blood from 38 patients with sALS, 28 aged-match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated monocyte/macrophages were observed in all patients with sALS and AD; the degree of activation was directly related to the rate of sALS disease progression. Other parameters of T-cell activation and immune globulin levels showed similar disease associated changes. These data are consistent with a disease model previously suggested for AD, wherein systemic immunologic activation plays an active role in sALS.
Zhang
Rongzhen
R
University of California, San Francisco, San Francisco General Hospital, 995 Potrero Avenue, Building 80, Ward 84, Box 0874, San Francisco, CA 94110, USA.
Gascon
Ron
R
Miller
Robert G
RG
Gelinas
Deborah F
DF
Mass
Jason
J
Hadlock
Ken
K
Jin
Xia
X
Reis
Jeremy
J
Narvaez
Amy
A
McGrath
Michael S
MS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007107:Immune System / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008262:Macrophage Activation; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D007074:Immunoglobulin G; D007075:Immunoglobulin M