Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders.
Two research groups have recently reported a significant association between schizophrenia and genetic variants of Frizzled-3 (FZD3) gene. We examined a possible association in a Japanese sample of schizophrenia, bipolar disorder, unipolar depression and controls with four single nucleotide polymorphisms (SNPs), tested in previous reports. We failed to find significant association in the four SNPs or haplotype analysis. The FZD3 gene might not play a role in conferring susceptibility to major psychosis in our sample.
Hashimoto
R
R
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Suzuki
T
T
Iwata
N
N
Yamanouchi
Y
Y
Kitajima
T
T
Kosuga
A
A
Tatsumi
M
M
Ozaki
N
N
Kamijima
K
K
Kunugi
H
H
D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D000094742:Secreted Frizzled-Related Proteins
D011506:Proteins; D000094742:Secreted Frizzled-Related Proteins