Fabrication and properties of a porous chitin/chitosan conduit for nerve regeneration.
A porous, biodegradable, natural chitin/chitosan nerve conduit was constructed. Scanning electron microscopy confirmed that it was homogeneous and highly porous. FT-IR spectra showed that there were no residues arising from the preparation process in the conduit. Addition of chitin to the chitosan solution increased the mechanical strength and maximum tensile strength from 7.2 to 9.6 MPa. Preliminary animal tests indicated that porous chitin/chitosan conduits did not swell in vivo and were compatible with surrounding tissue.
Yang
Yumin
Y
Institute of Functional Biomolecules, State Key Laboratory for Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China. yangym@ntmc.edu.cn
Gu
Xiaosong
X
Tan
Renxiang
R
Hu
Wen
W
Wang
Xiaodong
X
Zhang
Peiyun
P
Zhang
Tianyi
T
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002686:Chitin / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004548:Elasticity; D048091:Guided Tissue Regeneration / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008422:Materials Testing; D009416:Nerve Regeneration / Q000502:physiology*; D016062:Porosity; D051381:Rats; D017207:Rats, Sprague-Dawley; D020426:Sciatic Neuropathy / Q000473:pathology* / Q000601:surgery*; D013499:Surface Properties; D013718:Tensile Strength; D016896:Treatment Outcome
D001672:Biocompatible Materials; D002686:Chitin; D048271:Chitosan