title: Influence of gelatin-resorcin-formalin glue on mid-term redissection after aortic repair.
abstract: OBJECTIVE
  To determine whether the development of mid-term redissection after surgery for acute type A aortic dissection using gelatin-resorcin-formalin (GRF) glue could be prevented by applying less formalin.
  
  
  METHODS
  Between 1995 and 1999, 59 patients underwent surgery with GRF glue to repair acute type A aortic dissection. Forty-one patients underwent surgery before October 1998, and 18 patients underwent surgery after November 1998. An excessive amount of formalin was used in the former period and less was used in the latter period.
  
  
  RESULTS
  Follow-up computed tomography was done for 34 patients in the former period (Former group) and for 16 patients in the latter period (Latter group). This showed redissection in 19 of the 34 patients in the Former group and in 6 of the 16 patients in the Latter group. There was no significant difference in the frequency of mid-term redissection between the two groups.
  
  
  CONCLUSIONS
  The development of mid-term redissection of the aortic root was not prevented by applying less formalin in the GRF glue. Thus, we conclude that the cause of redissection is not entirely the result of too much formalin.
authors.affiliation: Department of Cardiovascular Surgery, Iwate Medical University Memorial Heart Center, Iwate Medical University, 1-2-1 Chuodori, Morioka 020-8505, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakajima
authors.forename: Kohei
authors.initials: K
authors.lastname: Kawazoe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Izumoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamada
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kataoka
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sugai
mesh_terms: D000368:Aged; D000784:Aortic Dissection / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005557:Formaldehyde / Q000008:administration & dosage* / Q000737:chemistry; D005780:Gelatin / Q000008:administration & dosage* / Q000737:chemistry; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D012008:Recurrence; D012118:Resorcinols / Q000008:administration & dosage* / Q000737:chemistry; D013997:Time Factors; D014014:Tissue Adhesives / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin