title: Circulating beta amyloid protein is elevated in patients with acute ischemic stroke.
abstract: Recent clinical and experimental studies suggest that ischemic strokes may play an important role in the pathogenesis of Alzheimer's disease (AD). Beta amyloid (Abeta), a major component of senile plaque in AD, is known to be derived from ischemic brain or activated platelets. We prospectively enrolled 62 patients with acute ischemic stroke and 27 age-matched controls. The serum Abeta and P-selectin levels were determined using the Sandwich-ELISA. We divided ischemic strokes into subgroups according to the clinical syndrome, pathogenesis, and infarct size, and compared the Abeta level between each subgroup. The Abeta1-40 level was markedly elevated in ischemic stroke patients, as compared to controls (140.2 +/- 54.0 vs 88.44 +/- 34.96 pg/ml, p<0.001). Cardioembolic and larger artery atherosclerotic infarcts had higher Abeta1-40 level than small vessel disease (p = 0.001). Both infarct size and the initial NIHSS score had significantly positive correlations with the serum level of Abeta1-40 (r = 0.539, p<0.001 and r = 0.425, p = 0.001, respectively). However, the P-selectin level was not significantly correlated with serum Abeta1-40. Our data suggest that elevated circulating Abeta1-40 in ischemic stroke patients may be derived from brain as a consequence of ischemic insults.
authors.affiliation: Department of Neurology, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: P H
authors.initials: PH
authors.lastname: Lee
authors.forename: O Y
authors.initials: OY
authors.lastname: Bang
authors.forename: E M
authors.initials: EM
authors.lastname: Hwang
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: U S
authors.initials: US
authors.lastname: Joo
authors.forename: I
authors.initials: I
authors.lastname: Mook-Jung
authors.forename: K
authors.initials: K
authors.lastname: Huh
mesh_terms: D000208:Acute Disease; D000368:Aged; D016229:Amyloid beta-Peptides / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood*; D015539:Platelet Activation; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D019007:P-Selectin; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40)