title: Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues.
abstract: The synthesis and the biological evaluation (acetylcholinesterase inhibition activity and neuroprotection) of the new tacrine analogues 2-14 is described.
authors.affiliation: Laboratorio de Radicales Libres (IQOG, CSIC), C/ Juan de la Cierva 3, 28006 Madrid, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: León
authors.forename: José
authors.initials: J
authors.lastname: Marco-Contelles
authors.forename: Antonio G
authors.initials: AG
authors.lastname: García
authors.forename: Mercedes
authors.initials: M
authors.lastname: Villarroya
mesh_terms: D000818:Animals; D002417:Cattle; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D019439:Chromaffin Cells / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013619:Tacrine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D018696:Neuroprotective Agents; D013619:Tacrine