CCL25 enhances CD103-mediated lymphocyte adhesion to E-cadherin.
Our results demonstrate that (1) CD103 is upregulated on CD8(+) T cells subsequent to their entry into the small intestinal epithelium, and (2) that the chemokine CCL25 enhances CD103-mediated adhesion to E-cadherin. These results suggest a novel role for chemokines in modulating interactions between lymphocytes and epithelial cells at mucosal surfaces.
Ericsson
Anna
A
Immunology Section, Department of Cell and Molecular Biology, Lund University, BMC I-13, SE-22184 Lund, Sweden. Anna.Ericsson@immuno.lu.se
Arya
Anu
A
Agace
William
W
D019264:Adoptive Transfer; D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D015820:Cadherins / Q000187:drug effects / Q000276:immunology*; D002448:Cell Adhesion / Q000187:drug effects / Q000276:immunology*; D019742:Chemokines, CC / Q000494:pharmacology*; D018928:Immunity, Mucosal; D039001:Integrin alpha Chains / Q000276:immunology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D010047:Ovalbumin / Q000276:immunology / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D015820:Cadherins; C491541:Ccl25 protein, mouse; D019742:Chemokines, CC; D039001:Integrin alpha Chains; C091367:alpha E integrins; D010047:Ovalbumin