title: A structure-taste study of arylsulfonyl(cyclo)alkanecarboxylic acids.
abstract: A number of sweeteners contain a sulfonyl group. In our current search for new glucophores several new compounds containing such group were obtained. A series of novel 1-phenylsulfonylcyklohexanecarboxylic acids and 2-arylsulfonylalkanecarboxylic acids was obtained and evaluated for their sweet taste quality. It has been found that methyl substituents are of the key importance for the activity of these compounds.
authors.affiliation: Department of Organic Chemistry, Institute of Chemistry, University of Silesia, PL-40-006 Katowice, Poland.
authors.forename: Violetta
authors.initials: V
authors.lastname: Lysiak
authors.forename: Aleksander
authors.initials: A
authors.lastname: Ratajczak
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Mencel
authors.forename: Krystyna
authors.initials: K
authors.lastname: Jarzembek
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Polanski
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013329:Structure-Activity Relationship; D013549:Sweetening Agents / Q000737:chemistry* / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects*
chemical_list: D002264:Carboxylic Acids; D013549:Sweetening Agents