Reduced immunogenicity of diphtheria and tetanus toxoids when combined with pertussis toxoid.
The effect of pertussis toxoid on the immunogenicity of diphtheria and tetanus toxoids (DT) was studied during a double blind efficacy trial of an acellular pertussis vaccine. Infants received DT with or without pertussis toxoid at 3, 5 and 12 months of age. Geometric mean concentrations were higher in the DT than in the DT-pertussis toxoid group 1 month (diphtheria toxoid 4.76 versus 3.58 IU/mL, P = 0.009; tetanus toxoid 4.42 versus 2.66 IU/mL, P < 0.0001) and 2 years after the third injection (diphtheria toxoid 0.15 versus 0.10 IU/mL, P < 0.0001; tetanus toxoid 0.38 versus 0.18 IU/mL, P < 0.0001). Pertussis toxoid causes a small but significant reduction of the immunogenicity of diphtheria toxoid and tetanus toxoid.
Trollfors
Birger
B
Department of Pediatrics, Sahlgrenska University Hospital and Göteborg University, Göteborg, Sweden.
Taranger
John
J
Lagergård
Teresa
T
Sundh
Valter
V
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D002675:Child, Preschool; D002522:Chlorocebus aethiops; D004165:Diphtheria / Q000517:prevention & control; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000276:immunology*; D022422:Diphtheria-Tetanus Vaccine / Q000008:administration & dosage / Q000276:immunology*; D004311:Double-Blind Method; D004347:Drug Interactions; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D013742:Tetanus / Q000517:prevention & control; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000276:immunology*; D014121:Toxoids / Q000008:administration & dosage / Q000276:immunology; D022282:Vaccines, Acellular / Q000008:administration & dosage / Q000276:immunology; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology*; D014709:Vero Cells; D014917:Whooping Cough / Q000517:prevention & control
D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D007074:Immunoglobulin G; D013745:Tetanus Toxoid; D014121:Toxoids; D022282:Vaccines, Acellular; D017778:Vaccines, Combined; C051093:pertussis toxoid