title: Four new neuroprotective dihydropyranocoumarins from Angelica gigas.
abstract: Four new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotective activity-guided isolation and were characterized as decursinol derivatives 4"-hydroxytigloyldecursinol (1), 4"-hydroxydecursin (2), (2"S,3"S)-epoxyangeloyldecursinol (3), and (2"R,3"R)-epoxyangeloyldecursinol (4), respectively. All four new dihydropyranocoumarins and major coumarin derivatives of A. gigas, decursinol and decursin, exhibited significant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical cells at concentrations ranging from 0.1 to 10 microM.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, San 56-1, Sillim-Dong, Gwanak-Gu, Seoul 151-742, Korea.
authors.forename: So Young
authors.initials: SY
authors.lastname: Kang
authors.forename: Ki Yong
authors.initials: KY
authors.lastname: Lee
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Sung
authors.forename: Young Choong
authors.initials: YC
authors.lastname: Kim
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018698:Glutamic Acid / Q000494:pharmacology; D007723:Korea; D015394:Molecular Structure; D009457:Neuroglia / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003374:Coumarins; D018696:Neuroprotective Agents; D018698:Glutamic Acid