Enhancement of T cell proliferative response against autologous cancer cells of a metasatic renal cell carcinoma patient after unexplained regression.
The unexplained regression of a metastasis of renal cell carcinoma (RCC) is rare phenomenon. While an immune mechanism has been proposed for spontaneous or unexplained regression of RCC, only limited data are available regarding immunological response. We report a case of a 62-year-old man with RCC whose paravertebral pleural tumor regressed after the withdrawal of interferon-alpha. In the present case, we demonstrate the enhancement of T cell proliferative response against autologous RCC cells secondary to the unexplained regression using the mixed-lymphocyte tumor culture. To our knowledge, the enhancement of an antitumor immunity secondary to an unexplained regression of RCC has not previously been reported.
Kawai
Koji
K
Department of Urology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305, Japan. rkawa@md.tsukuba.ac.jp
Saijo
Kaoru
K
Oikawa
Takehiro
T
Ohno
Tadao
T
Akaza
Hideyuki
H
D002292:Carcinoma, Renal Cell / Q000276:immunology* / Q000556:secondary*; D049109:Cell Proliferation; D006801:Humans; D016898:Interferon-alpha / Q000502:physiology; D007680:Kidney Neoplasms / Q000276:immunology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000276:immunology* / Q000556:secondary*; D012075:Remission, Spontaneous; D013601:T-Lymphocytes / Q000502:physiology
D016898:Interferon-alpha