title: Combined effects of estrogen and mechanical loading on anterior cruciate ligament fibroblast biosynthesis.
abstract: For some time, estrogen has been suspected to play a negative role in anterior cruciate ligament (ACL) fibroblast biosynthesis; however, reports on this issue have been controversial. In a recent study, our group demonstrated a negative combined effect of estrogen and mechanical loading on the gene expression of major extracellular matrix component molecules in ACL fibroblasts.
authors.affiliation: Sports Medicine Research Center, Department of Orthopedic Surgery, Baylor College of Medicine, 6550 Fannin Street, Suite 451, Houston, TX 77030, USA.
authors.forename: Xuhui
authors.initials: X
authors.lastname: Liu
authors.forename: Zong-Ping
authors.initials: ZP
authors.lastname: Luo
mesh_terms: D016118:Anterior Cruciate Ligament / Q000166:cytology* / Q000187:drug effects; D004967:Estrogens / Q000494:pharmacology*; D005109:Extracellular Matrix / Q000235:genetics / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D013314:Stress, Mechanical
chemical_list: D004967:Estrogens