Comparison of properties of spontaneous and radiation-induced mouse thymic lymphomas: role of Trp53 and radiation.
Mouse thymic lymphomas are readily induced by radiation and also arise without irradiation when the mice are null in Trp53 functions. In the present study, spontaneous thymic lymphomas in Trp53-/- mice were compared to those arising in irradiated Trp53+/- mice, revealing three features characteristic of the spontaneous lymphomas. (1) Mp53D2, a Trp53 modifier that affects the latent period of radiogenic thymic lymphomas in Trp53+/- mice, had no effect on the development of spontaneous lymphomas. (2) A sex difference in the latency was found. (3) A marked difference was noted in the frequency of allelic loss at the Ikaros gene on chromosome 11, encoding a transcription factor required for normal lymphocyte development and differentiation; 2% in the lymphomas of Trp53-/- mice and 78% in the radiogenic lymphomas of Trp53+/- mice, suggesting that loss of Trp53 may reduce the requirement for the loss of Ikaros for lymphomagenesis. Furthermore, allelic loss analysis on chromosome 19 localized a region that may harbor an unknown tumor suppressor gene. These results suggest intricate steps of lymphomagenesis influenced by the presence or absence of Trp53.
Kubota
Tomoyuki
T
Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1-757, Niigata 951-8122, Japan.
Yoshikai
Yoshihiro
Y
Tamura
Yasushi
Y
Mishima
Yukio
Y
Aoyagi
Yutaka
Y
Niwa
Ohtsura
O
Kominami
Ryo
R
D000818:Animals; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000235:genetics / Q000378:metabolism*; D011829:Radiation Dosage; D013953:Thymus Neoplasms / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*; D014916:Whole-Body Irradiation / Q000009:adverse effects
D016159:Tumor Suppressor Protein p53