title: Oxidative stress and uremia.
abstract: Oxidative stress is a pathogenic element of great importance in uremic patients, with a great impact on their survival. The cause of oxidative stress in patients on hemodialysis is traditionally attributed to the recurrent activation of polymorphonucleate neutrophils and monocytes. The effects of oxidative stress are evident on all biochemical components of biological tissues: lipids, proteins, carbohydrates, and nucleic acids. This study briefly reviews the effects of different dialytic techniques and of kidney transplant on several parameters of oxidative stress. Many different modalities of pharmaceutical intervention are then analyzed, and the clinical evidences reported.
authors.affiliation: Chair of Nephrology, Department of Internal Medicine, University of Messina, Italy.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Floccari
authors.forename: Carmela
authors.initials: C
authors.lastname: Aloisi
authors.forename: Eleonora
authors.initials: E
authors.lastname: Crascì
authors.forename: Tito
authors.initials: T
authors.lastname: Sofi
authors.forename: Susanna
authors.initials: S
authors.lastname: Campo
authors.forename: Donatella
authors.initials: D
authors.lastname: Tripodo
authors.forename: Manila
authors.initials: M
authors.lastname: Criseo
authors.forename: Nicola
authors.initials: N
authors.lastname: Frisina
authors.forename: Michele
authors.initials: M
authors.lastname: Buemi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D016030:Kidney Transplantation; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D011506:Proteins / Q000378:metabolism; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism* / Q000628:therapy
chemical_list: D000975:Antioxidants; D017127:Glycation End Products, Advanced; D011506:Proteins; D004247:DNA