title: Methyljasmonate accelerates catabolism of monoterpenoid indole alkaloids in Catharanthus roseus during leaf processing.
abstract: Variations in alkaloid pattern during drying of leaves (leaf processing) showed that treatment with methyljasmonate can induce formation of bisindole alkaloids as a result of catabolism of the monomeric alkaloids catharanthine and vindoline. A two-fold increase in 3',4'-anhydrovinblastine was shown in treated leaves especially from day 8 until day 21. Serpentine also increased in the same period under the treatment as a catabolic product of ajmalicine. Basic peroxidases that are responsible for the formation of anhydrovinblastine and serpentine showed high activity at days 8 and 21 in treated leaves, causing the increase in anhydrovinblastine and serpentine.
authors.affiliation: Department of Pharmacognosy, Section of Metabolomics, Institute of Biology Leiden, Leiden University, Leiden, The Netherlands. m.el-sayed@chem.leidenuniv.nl
authors.forename: Magdi
authors.initials: M
authors.lastname: El-Sayed
authors.forename: Rob
authors.initials: R
authors.lastname: Verpoorte
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D030008:Catharanthus / Q000187:drug effects / Q000378:metabolism*; D003517:Cyclopentanes / Q000494:pharmacology*; D006801:Humans; D054883:Oxylipins; D008517:Phytotherapy; D010937:Plant Growth Regulators / Q000494:pharmacology*; D046948:Secologanin Tryptamine Alkaloids / Q000378:metabolism*; D036226:Seedlings
chemical_list: D000085:Acetates; D003517:Cyclopentanes; D054883:Oxylipins; D010937:Plant Growth Regulators; D046948:Secologanin Tryptamine Alkaloids; C072239:methyl jasmonate