Chronic myeloid leukemia following kidney transplantation.
Immunosuppressed renal recipients are at an increased risk of developing cancer. Leukemias are less frequent than other hematopoietic tumours and development of CML after immunosuppression is rare. We describe a 37-year-old male who presented with left-shifted leukocytosis, hypercellular bone marrow 32 months after the kidney transplant. G-banding karyotype revealed 46,XY,t(9;22)(q34;q11) and the diagnosis of chronic myeloid leukemia was made. This is the 13th case of CML after kidney transplant reported. Whether this CML appeared as a random phenomenon or chemically induced is a matter of debate. Some individuals might have an increased susceptibility to the effects of azathioprine.
Pelloso
Luís Arthur Flores
LA
Disciplina de Hematologia e Hemoterapia, UNIFESP-EPM, Rua Botucatu 740, 04023-900 São Paulo, SP Brazil.
Campos
Mireille Guimarães Vaz de
MG
Nascimento
Marília
M
Silva
Maria Regina Régis
MR
Pestana
José Osmar Medina
JO
Chauffaille
Maria de Lourdes L F
Mde L
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology* / Q000276:immunology*; D008297:Male
D007166:Immunosuppressive Agents; D001379:Azathioprine