[Expression of telomerase activity and c-myc and stimulatory protein 1 in human ameloblastoma].
OBJECTIVE
To study the oncogene transcriptor c-myc, stimulatory protein 1 (SP1) expression in ameloblastoma (AB) and their relation with telomerase reverse transcripase (hTERT), and to investigate the clinical biological characteristics of AB.


METHODS
The expression was observed in AB by in situ hybridization and SP method.


RESULTS
The positive rates of c-myc mRNA, hTERT mRNA and SP1 protein were 81.5% (44/54), 94.4% (51/54) and 83.3% (45/54), respectively. Their positive rates increased as AB recurred and transformed malignantly. A strong correlation was found between hTERT and c-myc, hTERT and SP1 (rs = 0.853, P < 0.001; rs = 0.900, P < 0.001).


CONCLUSIONS
Activity of telomerase plays an important role in the tumorigenesis development of AB. Increasing of hTERT expression may be related to c-myc and SP1. The expression of these three parameters has a significant correlation with the clinical biological characteristics of AB.
Zhong
Ming
M
Dept. of Pathology, College of Stomatology, China Medical University, Shenyang 110002, China.
Li
Zi-juan
ZJ
Wang
Jie
J
Zhang
Bo
B
Hou
Lin
L
Gong
Yan-bing
YB
D000564:Ameloblastoma / Q000378:metabolism*; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D016329:Sp1 Transcription Factor / Q000378:metabolism*; D019098:Telomerase / Q000378:metabolism*
C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D016329:Sp1 Transcription Factor; D019098:Telomerase