FT-IR spectrophotometric analysis of dehydroepiandrosterone and its pharmaceutical formulation.
A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of dehydropeiandrosterone. Conventional KBr spectra and KBr + 2.0 mg microcrystalline cellulose (MCC) spectra were compared for best determination of active substance in drug formulation. Two chemometric approaches, partial least-squares (PLS) and principal component regression (PCR+) methods were used in data processing. The best results were obtained with PCR+ method.
Bunaciu
Andrei A
AA
ROMSPECTRA IMPEX SRL, Analytical Research Department, 25 Str. Maguricea, P.O. Box 52, Bucharest 3, Romania.
Aboul-Enein
Hassan Y
HY
Fleschin
Serban
S
D000276:Adjuvants, Immunologic / Q000032:analysis*; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D003687:Dehydroepiandrosterone / Q000032:analysis*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*
D000276:Adjuvants, Immunologic; D002214:Capsules; D003687:Dehydroepiandrosterone