The role of models in understanding CD8+ T-cell memory.
Immunological memory - the ability to 'remember' previously encountered pathogens and respond faster on re-exposure - is a central feature of the immune response of vertebrates. We outline how mathematical models have contributed to our understanding of CD8(+) T-cell memory. Together with experimental data, models have helped to quantitatively describe and to further our understanding of both the generation of memory after infection with a pathogen and the maintenance of this memory throughout the life of an individual.
Antia
Rustom
R
Department of Biology, Emory University, Atlanta, Georgia 30322, USA. rustom.antia@emory.edu
Ganusov
Vitaly V
VV
Ahmed
Rafi
R
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D018448:Models, Immunological