Molecular control of cytoskeletal mechanics by hemodynamic forces.
The endothelium at the interface between blood and tissue acts as a primary transducer of local hemodynamic forces into signals that maintain physiological function or initiate pathological processes in vessel walls. Rapid intracellular spatial gradients of structural dynamics and signaling molecule activity suggest that mechanical cues at the molecular level guide cellular mechanotransduction and adaptation to shear stress profiles.
Helmke
Brian P
BP
Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA. helmke@virginia.edu
D000199:Actins / Q000502:physiology; D000818:Animals; D003599:Cytoskeleton / Q000502:physiology*; D042783:Endothelial Cells / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D007382:Intermediate Filaments / Q000502:physiology; D013314:Stress, Mechanical
D000199:Actins