No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder.
OBJECTIVE
Serotonin type 1A receptors (5HT1ARs) have been shown to be affected by stress in experimental animals and related to anxiety and depression in humans. In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD).


METHODS
Using positron emission tomography and the radioligand [18F]FCWAY, the authors compared 5HT1AR binding between patients with PTSD and healthy subjects.


RESULTS
No significant differences in 5HT1AR distribution volume, binding potential, or tracer delivery were found.


CONCLUSIONS
5HT1AR expression may not be altered in patients with PTSD.
Bonne
Omer
O
Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892-2670, USA. bonneo@intra.nimh.nih.gov
Bain
Earle
E
Neumeister
Alexander
A
Nugent
Allison C
AC
Vythilingam
Meena
M
Carson
Richard E
RE
Luckenbaugh
David A
DA
Eckelman
William
W
Herscovitch
Peter
P
Drevets
Wayne C
WC
Charney
Dennis S
DS
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D003510:Cyclohexanes; D005260:Female; D005462:Fluorine Radioisotopes; D015870:Gene Expression; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010879:Piperazines; D049268:Positron-Emission Tomography; D011869:Radioligand Assay; D044282:Receptor, Serotonin, 5-HT1A / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D013313:Stress Disorders, Post-Traumatic / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism*; D014018:Tissue Distribution
D003510:Cyclohexanes; D005462:Fluorine Radioisotopes; C493883:N-(2-(4-(2-methoxyphenyl)piperazino))-N-(2-pyridinyl) trans-4-fluorocyclohexanecarboxamide; D010879:Piperazines; D044282:Receptor, Serotonin, 5-HT1A