Basal energy expenditure and diet- induced modifications to thermogenesis in short bowel syndrome.
OBJECTIVE
The influence of food intake on diet-induced thermogenesis, in the absence of parenteral nutrition, has not been assessed in short bowel syndrome (SBS) patients. We studied basal energy expenditure (BEE) and diet-induced thermogenesis in SBS patients (n=8) and paired healthy adult volunteer controls (n=8).


METHODS
Energy expenditure was measured by indirect calorimetry (IC) before and after control diet intake. All study participants received oral control diet randomly given in 3 doses (A=1.0, B=1.5 and C=2.0)x1/6 of BEE calories. Bioelectric impedance was assessed. Pairing criteria for controls were: age, sex, body mass index.


RESULTS
No significant differences were found between SBS and paired healthy control groups in relation to absolute BEE (P=0.146) and when it was adjusted for body mass index, lean and fat body mass (P=0.861, 0.208 and 0.574, respectively). All diets promoted thermogenesis in both groups. The interaction between the control diet (A, B and C) and SBS and healthy control groups for diet induced thermogenesis presented a significant difference (P=0.026). When comparing groups (SBS vs healthy controls) in relation to the control diet (B and C) we observed: P=0.030 and 0.004, respectively.


CONCLUSIONS
In patients with SBS it was observed that: (1) BEE measured by IC in absolute values or adjusted by lean body mass is similar to healthy control group; (2) Diet-induced thermogenesis was lower than the healthy control group for higher caloric diets (B and C).
Justino
Sandra R
SR
Nutrition and Diet Service, Hospital de Clínicas, Federal University of Paraná, Brazil. sandraju@terra.com.br
Dias
Maria Carolina Gonçalves
MC
Maculevicius
Janete
J
Colugnati
Fernando A Basile
FA
Sing
Teng Chang
TC
Halpern
Alfredo
A
Gama-Rodrigues
Joaquim
J
Waitzberg
Dan L
DL
D000328:Adult; D001481:Basal Metabolism / Q000502:physiology*; D001944:Breath Tests; D002153:Calorimetry, Indirect; D016022:Case-Control Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D017097:Electric Impedance; D002149:Energy Intake; D005260:Female; D005526:Food, Formulated; D006801:Humans; D008297:Male; D008875:Middle Aged; D012778:Short Bowel Syndrome / Q000378:metabolism*; D022722:Thermogenesis / Q000502:physiology*
D004040:Dietary Carbohydrates