Superiority of voriconazole over amphotericin B in the treatment of invasive aspergillosis after heart transplantation.
Invasive aspergillosis in immuncompromised patients occurs frequently. Surgical therapy in combination with chemotherapy with amphotericin B and itraconazole is standard therapy. We describe a heart transplant recipient with invasive Aspergillus fumigatus infection in the lung, which was treated successfully with voriconazole after systemically high-dose intravenous therapy with amphotericin B failed.
Wieland
Thomas
T
University Hospital of Regensburg, Department of Cardiothoracic Surgery, Franz-Josef-Strauss-Allee 11, Regensburg 93053, Germany. thomaswieland74@hotmail.com
Liebold
Andreas
A
Jagiello
Magda
M
Retzl
Gerald
G
Birnbaum
Dietrich E
DE
D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology*; D001232:Aspergillus fumigatus; D016027:Heart Transplantation; D006801:Humans; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000601:surgery; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology*; D011743:Pyrimidines / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole