title: The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy.
abstract: OBJECTIVE
  To describe changes of the foveal photoreceptor layer using optical coherence tomography (OCT) in central serous chorioretinopathy (CSC) and evaluate the correlation with visual acuity (VA) loss.
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  We studied 28 eyes with acute or chronic CSC using high-resolution OCT. The tomographic findings of the detached foveal photoreceptor layer were compared with VA. Sixteen eyes also were evaluated after foveal reattachment.
  
  
  RESULTS
  The outer photoreceptor layer (OPL) in the detached fovea was preserved in 14 eyes, of which 13 had symptoms for <1 year and atrophic in 14 eyes with symptoms for >1 year. The preserved OPL had an even profile in 7 eyes and a granulated profile in 7 eyes. Mean VA was 0.19 logMAR with a preserved OPL and 0.72 logMAR with an atrophic OPL (P <.001). Cases seen after the detachment resolved included 6 eyes with preserved even OPL, 5 eyes with preserved granulated OPL, and 5 eyes with atrophic OPL. Mean final VA was 0.06 logMAR in eyes with preserved OPL and 0.90 logMAR in eyes with atrophic OPL (P <.001). The VA improved in 73% of eyes with preserved OPL and no eyes with atrophic OPL (P = .025). The VA recovered completely in 83% of eyes with preserved even OPL and no eyes with preserved granulated OPL (P = .015).
  
  
  CONCLUSIONS
  High-resolution OCT demonstrates changes in the foveal photoreceptor layer in CSC that highly correlate with VA loss and may predict visual recovery after macular reattachment.
authors.affiliation: Institute of Ophthalmology, Department of Clinical Physiopathology, University of Torino, Torino, Italy. felice.cardillopiccolino@unito.it
authors.forename: Felice Cardillo
authors.initials: FC
authors.lastname: Piccolino
authors.forename: Roberta Rigault
authors.initials: RR
authors.lastname: de la Longrais
authors.forename: Giambattista
authors.initials: G
authors.lastname: Ravera
authors.forename: Chiara M
authors.initials: CM
authors.lastname: Eandi
authors.forename: Luca
authors.initials: L
authors.lastname: Ventre
authors.forename: Ali'
authors.initials: A
authors.lastname: Abdollahi
authors.forename: Marilisa
authors.initials: M
authors.lastname: Manea
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001837:Body Weights and Measures; D002908:Chronic Disease; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D007208:Indocyanine Green; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology*; D011446:Prospective Studies; D012163:Retinal Detachment / Q000175:diagnosis / Q000628:therapy; D012164:Retinal Diseases / Q000175:diagnosis* / Q000628:therapy; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis*; D014792:Visual Acuity
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green