title: Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships.
abstract: 1. The GABAergic neurotransmission has been implicated in the modulation of many neural networks in forebrain, midbrain and hindbrain, as well as, in several neurological disorders. 2. The complete comprehension of GABA system neurochemical properties and the search for approaches in identifying new targets for the treatment of neural diseases related to GABAergic pathway are of the extreme relevance. 3. The present review will be focused on the pharmacology and biochemistry of the GABA metabolism, GABA receptors and transporters. In addition, the pathological and psychobiological implications related to GABAergic neurotransmission will be considered.
authors.affiliation: Departament of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
authors.forename: Renê Oliveira
authors.initials: RO
authors.lastname: Beleboni
authors.forename: Ruither Oliveira Gomes
authors.initials: RO
authors.lastname: Carolino
authors.forename: Andrea Baldocchi
authors.initials: AB
authors.lastname: Pizzo
authors.forename: Lissandra
authors.initials: L
authors.lastname: Castellan-Baldan
authors.forename: Joaquim
authors.initials: J
authors.lastname: Coutinho-Netto
authors.forename: Wagner Ferreira
authors.initials: WF
authors.lastname: dos Santos
authors.forename: Norberto Cysne
authors.initials: NC
authors.lastname: Coimbra
mesh_terms: D000818:Animals; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D050485:GABA Plasma Membrane Transport Proteins; D006801:Humans; D026901:Membrane Transport Proteins / Q000502:physiology*; D018079:Receptors, GABA / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D050485:GABA Plasma Membrane Transport Proteins; D026901:Membrane Transport Proteins; D018079:Receptors, GABA; D005680:gamma-Aminobutyric Acid