Human eosinophils as potent inflammatory cells and their apoptosis.
A significant association was established between the eosinophil and a number of disease conditions, including helminthiasis, allergy, asthma, drug hypersensitivity, certain neoplasias, and graft rejection. Activation of eosinophils and release of proinflammatory lipid mediators, cytokines, free oxygen radicals, highly-charged cationic proteins contribute to the onset and maintenance of tissue inflammation. Eosinophil accumulation in blood and tissues has been related to a defect in their apoptotic death. Decisive events during the apoptotic process involve mitochondrial permeabilization and caspase activation. Clearance of apoptotic cells depends on the ability of phagocytes to recognize their cell targets and, subsequently, to engulf them. (Tab. 2, Ref. 32.)
Horvathova
M
M
Research Base of the Slovak Medical University, Institute of Preventive and Clinical Medicine, Bratislava. mira.horvathova@szu.sk
D017209:Apoptosis; D004804:Eosinophils / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*