Synthesis and cytotoxic activity of thiazolofluorenone derivatives.
The synthesis and biological evaluation of some novel thiazolofluorenones, thiazolofluorenes and thiazoloanthraquinones, substituted with amino side-chains are described. These polyheterocyclic compounds have been synthesized via the corresponding imino-1,2,3-dithiazoles. Their cytotoxic activity and their eventual selective effect on a phase of the cell cycle were evaluated in vitro, using the murine lymphocytic L1210 leukaemia cell line.
Chabane
Hadjila
H
Groupe de Chimie Organique, Laboratoire de Biotechnologies et de Chimie Bio-organique, FRE 2766, Université de La Rochelle, Avenue Michel Crépeau, 17042 La Rochelle, France.
Pierre
Alain
A
Leonce
Stephane
S
Pfeiffer
Bruno
B
Renard
Pierre
P
Thiery
Valerie
V
Guillaumet
Gerald
G
Besson
Thierry
T
D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000880:Anthraquinones; D005449:Fluorenes