title: Cardiac wall motion abnormalities observed in a patient with transient hyperthyroidism.
abstract: A 74-year-old woman, with a history of hypertension and hyperlipidemia, was admitted to our hospital. She was found to have a sinus tachycardia with ST-segment elevations in leads II, III, (a)V(F), and V(3) through V(6) in electrocardiography, hypokinesis of the left ventricular apex by echocardiography, and normal findings on coronary angiography. Blood analysis revealed an increase in the creatine kinase MB fraction, a significant positive detection in troponin T, and transient elevations in the concentrations of free triiodothyronine, free thyroxine, thyroid globulin antibody, and thyroid peroxidase antibody. Defects in myocardial perfusion and fatty acid metabolism in the apical area were also demonstrated by myocardial scintigraphy. These data suggest that tako-tsubo syndrome or myocardial infarction may be induced in patients with mild and transient hyperthyroidism.
authors.affiliation: Department of Internal Medicine, Division of Coronary Heart Disease, Hyogo College of Medicine, Japan.
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Sakaki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Fujioka
authors.forename: Takafumi
authors.initials: T
authors.lastname: Akagami
authors.forename: Miho
authors.initials: M
authors.lastname: Masai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimizu
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Sakoda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsujino
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Ohyanagi
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D006980:Hyperthyroidism / Q000150:complications / Q000503:physiopathology*; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000150:complications; D013616:Tachycardia, Sinus / Q000175:diagnosis; D018487:Ventricular Dysfunction, Left / Q000150:complications