title: Normal hematological indices, blood chemistry and histology and ultrastructure of pancreatic islets in the wild Indian bonnet monkeys (Macaca radiata radiata).
abstract: The present study is aimed at determining some haematological and biochemical parameters in the wild Indian bonnet monkeys as also the microscopic and ultrastructural characteristics of their pancreatic islets. Adult wild Indian bonnet monkeys (Macaca radiata radiata) of both sexes weighing between 2.5 and 4 kg were used in these experiments. Their platelet, reticulocyte and total leukocyte counts and the blood concentrations of hemoglobin and plasma proteins and the serum concentrations of aspartate amino transferase, alanine amino transferase and calcium are similar to the values reported for M. mulatta. Plasma glucose is lower when compared with reported values of M. mulatta and M. fascicularis. Insulin levels are comparable with those of M. mulatta and M. nigra. Histology of islets is similar to that of humans. Ovoid cell collections of islet cells are scattered throughout the pancreas. Ultrastructure of A, B and D cells is similar to humans. These findings suggest that this relatively underutilized macaques may be a suitable model for biomedical research.
authors.affiliation: Department of Physiology, Christian Medical College, Vellore, Tamilnadu, India.
authors.forename: M Daisy
authors.initials: MD
authors.lastname: Mythili
authors.forename: Rashmi
authors.initials: R
authors.lastname: Vyas
authors.forename: S Susama
authors.initials: SS
authors.lastname: Patra
authors.forename: S C
authors.initials: SC
authors.lastname: Nair
authors.forename: G
authors.initials: G
authors.lastname: Akila
authors.forename: Rebecca
authors.initials: R
authors.lastname: Sujatha
authors.forename: S
authors.initials: S
authors.lastname: Gunasekaran
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001786:Blood Glucose; D001798:Blood Proteins; D002118:Calcium / Q000097:blood; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000648:ultrastructure*; D008255:Macaca radiata / Q000033:anatomy & histology* / Q000097:blood*; D008854:Microscopy, Electron; D013045:Species Specificity
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D007328:Insulin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002118:Calcium