title: Topiramate (Topamax) for prevention of migraine.
abstract: Topiramate is the second antiepileptic drug, after valproate, to be approved by the FDA for prevention of migraine. There is no evidence that it is more effective than a beta-blocker for this indication, and it is much more expensive. Topiramate can cause cognitive impairment and weight loss. No studies have compared it to valproate for this indication.
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000139:chemically induced; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D008881:Migraine Disorders / Q000517:prevention & control*; D000077236:Topiramate; D015431:Weight Loss / Q000187:drug effects
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose