title: Thrombolytic agents for arterial and venous thromboses in neonates.
abstract: BACKGROUND
  Clinically symptomatic thromboses are infrequent but serious complications in infants undergoing intensive care. Most are related to central vascular catheters. Symptomatic thrombosis may cause severe morbidity due to irreversible organ damage and also loss of limbs.
  
  
  OBJECTIVE
  To assess the efficacy and safety of thrombolytic agents in neonatal arterial and venous thromboses.
  
  
  METHODS
  We searched the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 2, 2004), MEDLINE (January 1966 to January 2004), EMBASE (January 1980 to January 2004), and CINAHL (January 1982 to January 2004). We also contacted authors of appropriate review articles.
  
  
  METHODS
  Randomised controlled trials (RCT) and quasi RCT comparing thrombolytic agents with either heparin or observation in neonates with symptomatic neonatal arterial and venous thromboses were included.
  
  
  METHODS
  Two reviewers independently searched for eligible trials. No eligible studies were found even after contacting authors of review articles for details of any unpublished trials.
  
  
  RESULTS
  No randomised controlled trials (RCT) or quasi-RCT were found.
  
  
  CONCLUSIONS
  No conclusions could be made as no eligible studies were found. It is time that a randomised controlled trial was performed comparing thrombolytic therapy to heparin therapy to aid neonatologists in the treatment of arterial and venous thromboses.
authors.affiliation: Paediatrics, Neonatal Unit, Liverpool Womens Hospital, crown Street, Liverpool L8 7SS, Liverpool Womens Hospital, Crown street, Liverpool, Merseyside, UK, L8 7SS. cherijohn25@hotmail.com
authors.forename: C M
authors.initials: CM
authors.lastname: John
authors.forename: C
authors.initials: C
authors.lastname: Harkensee
mesh_terms: D001158:Arteries; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy*; D020246:Venous Thrombosis / Q000188:drug therapy
chemical_list: D005343:Fibrinolytic Agents