Effects of aldosterone on forearm vasculature in treated chronic heart failure.
The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.
Gunaruwan
Prasad
P
Department of Cardiovascular Medicine, Medical School, University of Birmingham, Edgbaston, Birmingham, United Kingdom.
Schmitt
Matthias
M
Sharman
James
J
Lee
Leong
L
Struthers
Alan
A
Frenneaux
Michael
M
D000368:Aged; D000450:Aldosterone / Q000008:administration & dosage*; D000704:Analysis of Variance; D001783:Blood Flow Velocity; D004305:Dose-Response Relationship, Drug; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D012039:Regional Blood Flow; D014655:Vascular Resistance / Q000187:drug effects
D000450:Aldosterone