A whole lotta jumpin' goin' on: new transposon tools for vertebrate functional genomics.
Genome sequences of vertebrate model organisms are becoming available, fuelling the next challenging phase of research: annotating all of the genes with functional information. The functional annotation of all of the approximately 35 000 genes in mammals will undoubtedly require complementing the technologies of forward and reverse genetics in mutagenesis screens. Two recent articles report on the construction of retrotransposable elements that efficiently 'jump' in mammalian cells. These new elements hold great promise as useful vectors for insertional mutagenesis screens in the mouse.
Ivics
Zoltán
Z
Max Delbrück Center for Molecular Medicine, Berlin, Germany. zivics@mdc-berlin.de
Izsvák
Zsuzsanna
Z
D000818:Animals; D004251:DNA Transposable Elements / Q000235:genetics*; D019143:Evolution, Molecular; D023281:Genomics / Q000379:methods*; D006801:Humans; D014714:Vertebrates / Q000235:genetics*
D004251:DNA Transposable Elements