title: Predicting vascular risk in Type 1 diabetes: stratification in a hospital based population in Scotland.
abstract: OBJECTIVE
  To estimate the absolute cardiovascular risk of patients with Type 1 diabetes attending hospital diabetes clinics in Scotland and to develop a method for identifying those at highest risk, thus enabling therapy to be targeted.
  
  
  METHODS
  Baseline information was collected for 2136 patients with Type 1 diabetes using the Royal College of Physicians of Edinburgh Diabetes Register. These records were then linked to diagnoses of macrovascular disease in databases of the Information Statistics Division of the Common Services Agency.
  
  
  RESULTS
  During six to nine years of follow up 110 patients (5%) developed macrovascular disease. There were significant associations between baseline age (P < 0.00001), blood pressure (P < 0.00001), albuminuria (P < 0.0002), HbA1c (P < 0.001), cholesterol (P < 0.00001) and smoking status (P < 0.00001) with the development of macrovascular disease. A scoring system for future macrovascular risk was developed from a multivariate analysis of this data.
  
  
  CONCLUSIONS
  The data confirm the high vascular risk of patients with Type 1 diabetes. The relationship with age is such that those patients above 50 years require only one additional risk factor to reach such a high vascular risk that intervention is indicated. Using these data many patients between the age of 40 and 49 years are also likely to be identified to be at high risk.
authors.forename: Susan
authors.initials: S
authors.lastname: Lewis
authors.forename: Margaret
authors.initials: M
authors.lastname: MacLeod
authors.forename: John
authors.initials: J
authors.lastname: McKnight
authors.forename: Andrew
authors.initials: A
authors.lastname: Morris
authors.forename: Norman
authors.initials: N
authors.lastname: Peden
authors.forename: Robin
authors.initials: R
authors.lastname: Prescott
authors.forename: James
authors.initials: J
authors.lastname: Walker
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000453:epidemiology*; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D018572:Disease-Free Survival; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012606:Scotland / Q000453:epidemiology
chemical_list: D006442:Glycated Hemoglobin