title: Autografting followed by a reduced-intensity conditioning unrelated donor cord blood transplantation for a patient with refractory multiple myeloma: successful engraftment with minimal toxicity.
abstract: We report on a 59-yr-old man with recurrent multiple myeloma. To reduce treatment-related mortality, while retaining the cytoreductive effects of high-dose chemotherapy, as well as graft vs. myeloma effect, we used a reduced-intensity conditioning umbilical cord blood (CB) transplantation following high-dose chemotherapy with autologous stem cell transplantation support. This patient was engrafted rapidly and extramedullary toxicities were acceptable. Although he had local recurrence in the right calf on day +130 after the CB transplantation, the tumor was successfully treated with radiation therapy, and he is alive and well at present (day +480).
authors.affiliation: Third Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ando
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Yujiri
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tominaga
authors.forename: Sonoe
authors.initials: S
authors.lastname: Shinya
authors.forename: Toru
authors.initials: T
authors.lastname: Takahashi
authors.forename: Jun
authors.initials: J
authors.lastname: Nomiyama
authors.forename: Masato
authors.initials: M
authors.lastname: Seguchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Matsubara
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Fujii
authors.forename: Yukio
authors.initials: Y
authors.lastname: Tanizawa
mesh_terms: D036101:Cord Blood Stem Cell Transplantation; D006085:Graft Survival; D020350:Graft vs Tumor Effect; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000401:mortality / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D012074:Remission Induction; D014019:Tissue Donors; D018183:Transplantation Chimera; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous