title: Magnetic resonance spectroscopy of premalignant and malignant endometrial disorders: a feasibility of in vivo study.
abstract: OBJECTIVE
  To assess the potential clinical utility of in vivo proton magnetic resonance spectroscopy (MRS) in patients with various endometrial lesions.
  
  
  METHODS
  Twelve patients with untreated uterine bleeding were included in this study. In-vivo proton MRS was performed using a 1.5 T MR scanner. The metabolite levels were classified into three classes in comparison with the noise level by visual examination. All the patients have endometrial biopsy. For each type of lesions, chemical compound were described.
  
  
  RESULTS
  Pathological examination resulted in three endometrial cancer, two simple hyperplasias, one complex hyperplasia, two partial hydatiform mole, two proliferative endometrium and two secretory endometrium. In women with endometrial carcinoma, high choline and lipid signals were detected, whereas no creatine and no lactate signals were found. In women with endometrial hyperplasia, choline signal was detectable in all cases but one case showed lactate signal in addition to choline. In women with partial hydatidiform mole, the only detectable signal was choline. Lipid signals were detected in none of the cases with endometrial hyperplasia and partial hidatidiform mole. In women with either secretory or proliferative endometrium, choline and lactate signals were detectable in all cases but one case showed solely choline. Lipid signals were not detected in any of subjects with secretory or proliferative endometrium.
  
  
  CONCLUSIONS
  The observed difference is the presence of lipid signal only in endometrial carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Ozal Medical Center, School of Medicine, Inonu University, 44069 Malatya, Turkey. oncelik@inonu.edu.tr
authors.forename: Onder
authors.initials: O
authors.lastname: Celik
authors.forename: Seyma
authors.initials: S
authors.lastname: Hascalik
authors.forename: Kaya
authors.initials: K
authors.lastname: Sarac
authors.forename: M Mutlu
authors.initials: MM
authors.lastname: Meydanli
authors.forename: Alpay
authors.initials: A
authors.lastname: Alkan
authors.forename: Bulent
authors.initials: B
authors.lastname: Mizrak
mesh_terms: D000328:Adult; D000368:Aged; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D004714:Endometrial Hyperplasia / Q000473:pathology; D016889:Endometrial Neoplasms / Q000378:metabolism / Q000473:pathology*; D004717:Endometrium / Q000737:chemistry / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000473:pathology; D019344:Lactic Acid / Q000032:analysis; D008055:Lipids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy
chemical_list: D008055:Lipids; D019344:Lactic Acid; D003401:Creatine; D002794:Choline