Rhabdomyolysis after simvastatin therapy in an HIV-infected patient with chronic renal failure.
We encountered a 49-year-old HIV-infected man with chronic renal insufficiency who developed rhabdomyolysis after treatment with simvastatin. He recovered after initiating hemodialysis and discontinuing oral medications. Rhabdomyolysis most likely resulted from an excessive blood concentration of simvastatin caused by concomitant use of fluconazole in the presence of renal insufficiency.
Moro
Hiroshi
H
Division of Infection Control and Prevention, Niigata University Graduate School of Medical and Dental Sciences, Niigata University Medical School, Niigata, Japan.
Tsukada
Hiroki
H
Tanuma
Atsuto
A
Shirasaki
Arimasa
A
Iino
Noriaki
N
Nishibori
Takeaki
T
Nishi
Shinichi
S
Gejyo
Fumitake
F
D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000009:adverse effects*; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000188:drug therapy* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012206:Rhabdomyolysis / Q000139:chemically induced*; D019821:Simvastatin / Q000009:adverse effects*
D000924:Anticholesteremic Agents; D019821:Simvastatin