Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe.
A new diglucoside having a 5-methylchromone moiety was isolated from a commercial sample of Cape aloe, the dried exudate from Aloe ferox Miller, and named aloeresin I. Its structure was established as 1 on the basis of spectral and chemical evidence. Aloeresin I (1) (1 micromol/cm2) reduces in vivo the oedematous response (39 %) induced by Croton oil in the mouse ear with the same potency as aloesin, one of the most abundant Cape aloe constituents, and to a higher extent than aloeresin H (2). Indomethacin (0.3 micromol/cm2), the reference anti-inflammatory compound, provokes 61 % oedema inhibition.
Speranza
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Dipartimento di Chimica Organica e Industriale, Universitá degli Studi di Milano, Italy. giovanna.speranza@unimi.it
Morelli
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CF
Tubaro
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Altinier
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Durì
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Manitto
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D000504:Aloe; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002867:Chromones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003436:Croton Oil; D004187:Disaccharides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones; D004187:Disaccharides; D010936:Plant Extracts; C497983:aloeresin I; D003436:Croton Oil