Effect of hyperhomocysteinemia induced by methionine administration on flow-mediated dilatation of the brachial artery in healthy subjects.
Homocysteine may contribute to systolic hypertension and cardiac events by decreasing conduit artery compliance and inducing endothelial dysfunction. The effects of the experimental induction of hyperhomocysteinemia on systemic arterial compliance and pulsewave velocity are unclear, with contradictory results from previous studies. The investigators tested whether oral methionine impairs brachial artery compliance in addition to endothelial function.
Al-Shaer
Moutasim H
MH
Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Raghuveer
Geetha
G
Browning
Roger
R
Sinkey
Christine A
CA
Chenard
Catherine
C
Stumbo
Phyllis
P
Haynes
William G
WG
D000284:Administration, Oral; D000328:Adult; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000139:chemically induced*; D016014:Linear Models; D008297:Male; D008715:Methionine / Q000008:administration & dosage / Q000494:pharmacology*; D018608:Ultrasonography, Doppler
D008715:Methionine