Polygynax in the treatment of fungal and non specific vaginitis.
BACKGROUND
Polygynax is a product commercialized in the form of vaginal capsule, associating bactericidal antibiotics: Neomycin, Polymyxin B and Nystatin--an antifungal agent which is fungicidal and fungistatic in vitro and in vivo.


OBJECTIVE
The objectives of the study were to analyze the clinical and bacteriological efficacy of Polygynax in the treatment of bacterial vaginitis with one or more germs (mixed vaginitis) and Candida infections, and to investigate the correlation between the results of the initial clinical examination and bacteriological studies.


METHODS
The study covered 88 patients diagnosed with mixed vaginitis during initial screening of vaginal flora (direct Gram stains and standard microbiology laboratory methods for cultivation of vagina/ cervix smears with antibiotic susceptibility testing). The patients were treated with Polygynax, applied in form of vaginal capsules (during 12 days, application before retiring). After at least 30 days following last day of therapy, the same diagnostic swabs were repeated. In this period, averaging 38.4 days, sexual abstinence was recommended.


RESULTS
The results showed that total clearance of present germs was found in 83/88 patients (94.3% of the cases), according to the repeated cervico- vaginal smears.


CONCLUSIONS
Polygynax is a treatment of preference against fungal infections, with added advantage of having wide antibacterial spectrum.
Goran
Dimitrov
D
Department of Gynecology and Obstetrics, Clinical Centre, Skopje.
Vesna
Antovska
A
Adela
Stefanija
S
Biljana
Trajkovska-Kiurcik
TK
Snezana
Milenkova
M
D001152:Arsenicals / Q000008:administration & dosage / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology; D004338:Drug Combinations; D005260:Female; D006801:Humans; D009355:Neomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D009761:Nystatin / Q000008:administration & dosage / Q000627:therapeutic use*; D011113:Polymyxins / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014626:Vaginal Smears; D016585:Vaginosis, Bacterial / Q000188:drug therapy* / Q000382:microbiology
D001152:Arsenicals; D004338:Drug Combinations; D011113:Polymyxins; D009761:Nystatin; C006119:acetarsol, dimethicone, neomycin, nystatin, polymyxin drug combination; D009355:Neomycin