Damage to cell DNA in the bone marrow and testes of mice with experimental trichinosis.
Metabolites of Trichinella spiralis produced genotoxic and cytotoxic effects on somatic and generative cells of the host organism. They increased the number of single-chain breaks, alkaline-labile sites in nuclear DNA, and count of apoptotic cells in the bone marrow and testes of infected mice. These effects depended on the stage of parasite development in the host organism and became more pronounced with increasing invasion intensity.
Bekish
Vl Ya
VY
Department of Medical Biology and General Genetics, Vitebsk State Medical University, Moscow. bekishvl@tut.by
Durnev
A D
AD
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure*; D002460:Cell Line; D020552:Comet Assay; D004249:DNA Damage; D008297:Male; D051379:Mice; D013737:Testis / Q000648:ultrastructure*; D017160:Trichinella spiralis / Q000378:metabolism; D014235:Trichinellosis / Q000473:pathology*