[Cerebral malaria, a key role for endothelial cells?].
Five to six hundred millions of people, throughout the world, suffer from malaria and more than one million die each year as a consequence, in about 20% of the cases, of cerebral malaria, an important complication of Plasmodium falciparum infection (Holding & Snow, 2001). Despite many studies, the physiopathology of these cerebral occurrences is not understood, especially concerning the intricacy and respective roles of the various mechanisms identified: sequestration of parasitized red cells in microvessels, cytokine secretion, changes in the T lymphocyte repertoire, host genetic factors driving sensitivity pathogenic factors from Plasmodium (Mazier et al., 2000).
Pino
Paco
P
INSERM U511, Immunobiologie Cellulaire et Moléculaire des Infections Parasitaires, Centre Hospitalier-Universitaire Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France.
Nitcheu
Josiane
J
Mazier
Dominique
D
D000818:Animals; D017209:Apoptosis; D002448:Cell Adhesion; D002560:Cerebrovascular Circulation; D016207:Cytokines / Q000502:physiology; D003602:Cytotoxicity, Immunologic; D042783:Endothelial Cells / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology; D016779:Malaria, Cerebral / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008833:Microcirculation; D008954:Models, Biological; D018384:Oxidative Stress; D010962:Plasmodium berghei; D019707:Receptors, Chemokine / Q000502:physiology
D016207:Cytokines; D019707:Receptors, Chemokine