title: Olanzapine-induced diabetes in a seven-year-old boy.
abstract: The atypical antipsychotics have been recognized to induce diabetes mellitus and ketoacidosis in the adult psychiatric population. This report notes the onset of weight gain, diabetes, and apparent ketosis in a prepubertal boy diagnosed with bipolar disorder and treated with olanzapine. The hyperglycemia rapidly normalized after discontinuation of the olanzapine. Within 2 years, the diabetes recurred. In spite of the normalization of blood-glucose levels, urine ketone tests remained positive and were explained by the fact that patients taking valproic acid may have a false-positive urine test for ketones. Regular monitoring of glucose should be considered in children and adolescents who gain weight while treated with atypical antipsychotics.
authors.affiliation: Division of Child and Adolescent Psychiatry Division, Department of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, MD 21287-3325, USA. hcourvoi@jhmi.ed
authors.forename: Helen E
authors.initials: HE
authors.lastname: Courvoisie
authors.forename: David W
authors.initials: DW
authors.lastname: Cooke
authors.forename: Mark A
authors.initials: MA
authors.lastname: Riddle
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy*; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced*; D006801:Humans; D008297:Male; D000077152:Olanzapine; D012008:Recurrence
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine