[Cyclosporin treatment of interstitial pneumonia and monitoring of serum concentration].
Recently, cyclosporin has been reported to be a promising drug for the treatment of interstitial pneumonia. Monitoring of the serum cyclosporin concentration is important for the safety and efficacy of treatment. We measured the concentrations of this drug just before (C0) and 2 hours after (C2) administration, and the area under the concentration-time curve from the start of administration for 5 hours (AUC 0-5) in 58 patients. We found that C2 has the strongest correlation with AUC 0-5, which indicates the efficacy of cyclosporin. In 11 cases of interstitial pneumonia, 5 showed deterioration despite cyclosporin treatment. Three of those 5 cases had low C2 and AUC 0-5 levels, indicating that they were low absorbers and slow absorbers, which may be associated with a poor response. Therefore, the monitoring of the cyclosporin concentration is important especially in progressive cases of interstitial pneumonia that deteriorate despite cyclosporin treatment.
Enomoto
Noriyuki
N
Second Department of Medicine, Hamamatsu University School of Medicine.
Suda
Takafumi
T
Hashimoto
Dai
D
Naito
Tateaki
T
Fujisawa
Tomoyuki
T
Miwa
Seiichi
S
Nakano
Hideki
H
Suzuki
Kenichiro
K
Yokomura
Koshi
K
Ide
Kyotaro
K
Chida
Kingo
K
D000368:Aged; D019540:Area Under Curve; D016572:Cyclosporine / Q000097:blood* / Q000627:therapeutic use*; D003882:Dermatomyositis / Q000150:complications; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood* / Q000627:therapeutic use*; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000150:complications
D007166:Immunosuppressive Agents; D016572:Cyclosporine