title: Three new taxane diterpenoids from Taxus sumatrana.
abstract: Phytochemical investigation of taxane diterpenoidal content of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of three new taxoid compounds, tasumatrols E (1), F (2), and G (3) together with 13 known taxanes (5-16). The structures of these taxanes as well as their derivatives were established on the basis of spectroscopic analyses, especially 1D and 2D NMR. Compounds 1, 2, 12, and 16 exhibited significant cytotoxicity against human A-498, NCI-H226, A549, and PC-3 tumor cells.
authors.affiliation: Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan 80424, Republic of China. ycshen@mail.nsysu.edu.tw
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Kuen-Ching
authors.initials: KC
authors.lastname: Cheng
authors.forename: Yun-Chi
authors.initials: YC
authors.lastname: Lin
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.forename: Ashraf Taha
authors.initials: AT
authors.lastname: Khalil
authors.forename: Jih-Hwa
authors.initials: JH
authors.lastname: Guh
authors.forename: Ching-Te
authors.initials: CT
authors.lastname: Chien
authors.forename: Che-Ming
authors.initials: CM
authors.lastname: Teng
authors.forename: Yao-To
authors.initials: YT
authors.lastname: Chang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan; D043823:Taxoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020946:Taxus / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; C497958:tasumatrol E; C497959:tasumatrol F; C497960:tasumatrol G