Ru-catalyzed asymmetric hydrogenation of alpha-phthalimide ketones and 1,3-diaryl diketones using 4,4'-substituted BINAPs.
[reaction: see text] A family of tunable precatalysts [NH2Et2][{Ru(4,4'-BINAP)Cl}2(mu-Cl)3] was synthesized and used for highly enantioselective hydrogenation of phthalimide-protected amino ketones and 1,3-diaryldiketones. The bulky groups on the 4,4'-positions of BINAP were believed to be responsible for the enhancement of enantioselectivity (and diasteroselectivity) in these reactions.
Hu
Aiguo
A
Department of Chemistry, CB 3290, University of North Carolina, Chapel Hill, NC 27599, USA.
Lin
Wenbin
W