Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the larynx.
BACKGROUND
Mucosa-associated lymphoid tissue (MALT) lymphoma is usually associated with a chronic inflammatory disease from which lymphoid tissue of MALT type arises as a prerequisite for lymphoma proliferation. No well-characterized chronic inflammatory process has been identified in the larynx.


METHODS
We report a case of primary MALT lymphoma of the larynx associated with extraesophageal reflux, chronic laryngitis, and gastric Helicobacter pylori infection, raising the issue of its physiopathology and treatment.


RESULTS
Treatment of this MALT lymphoma of the larynx consisted of complete surgical excision associated with omeprazole, amoxicillin, and clarithromycin. No evidence of disease was observed after 24 months of follow-up.


CONCLUSIONS
We may assume that chronic laryngitis could be a precursor to MALT lymphoma. This case is the first one to our knowledge of a primary MALT lymphoma of the larynx treated with conservative management combining surgical excision, reflux therapy, and eradication of gastric H. pylori infection.
Kania
Romain E
RE
Department of Otorhinolaryngology-Head and Neck Surgery, Hôpital Européen Georges Pompidou, 20, rue Leblanc, 75015 Paris, France.
Hartl
Dana M
DM
Badoual
Cécile
C
Le Maignan
Christine
C
Brasnu
Daniel F
DF
D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery