Medial temporal lobe atrophy and memory deficits in elderly stroke patients.
Medial temporal lobe atrophy (MTA) and its role in memory deficits have been studied extensively in patients with various dementias and non-degenerative neurologic diseases. In stroke patients MTA is a significant risk factor for dementia. However, its role in memory decline in non-demented stroke patients is not yet known. Our aim was to evaluate the relationship between MTA and cognitive functions in a large cohort of elderly patients, who underwent a comprehensive neuropsychologic examination and magnetic resonance imaging 3 months after an ischemic stroke. The study sample (n = 260) was divided into three groups according to the severity of MTA. After adjusting for age, volume of infarcts and cortical atrophy, we found that patients with moderate to severe MTA performed significantly worse in tests of learning, story recall, visual reproduction, block design and mental speed. In contrast, the groups did not differ in tests of digit span, flexibility, verbal fluency and conceptualization. Our conclusion is that in aged stroke patients, MTA is associated with poor performance in specific cognitive domains. The most vulnerable domains are memory and visuospatial functions, whereas verbal and executive functions seem to be unrelated to MTA.
Jokinen
H
H
Department of Psychology, University of Helsinki, Helsinki, Finland. hanna.jokinen@helsinki.fi
Kalska
H
H
Ylikoski
R
R
Hietanen
M
M
Mäntylä
R
R
Pohjasvaara
T
T
Kaste
M
M
Erkinjuntti
T
T
D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001284:Atrophy; D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D003710:Demography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000473:pathology*; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011340:Problem Solving / Q000502:physiology; D011446:Prospective Studies; D011597:Psychomotor Performance / Q000502:physiology; D012189:Retrospective Studies; D020521:Stroke / Q000150:complications* / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology*; D014705:Verbal Behavior / Q000502:physiology