Adenine nucleotides and dinucleotides as new substances for the treatment of ocular hypertension and glaucoma.
The potential utility of naturally occurring nucleotide compounds in the treatment of ocular hypertension and glaucoma is described. Nucleotides are compounds that can modify the hydrodynamics of the aqueous humor by modulating the activity of nerve terminals that control the drainage and production of aqueous humor in the eye. Their mechanisms of action are focused on reducing intraocular pressure, thereby preventing optic nerve damage. These agents are candidates for the treatment of ocular hypertension and glaucoma.
Pintor
Jesús
J
Departamento de Bioquimica y Biologia Molecular IV, EU Optica, Universidad Complutense de Madrid, Madrid, Spain. jpintor@vet.ucm.es
D000227:Adenine Nucleotides / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D015226:Dinucleoside Phosphates / Q000494:pharmacology / Q000627:therapeutic use*; D005901:Glaucoma / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D009798:Ocular Hypertension / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D058469:Receptors, Purinergic P2X
D000227:Adenine Nucleotides; D015226:Dinucleoside Phosphates; D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X