The role of transforming growth factor-{beta} in a model of oral tolerance to the diet antigen dextrin.
In a model of immunodeficiency provoked by protein deficiency, cytosol fractions from gut IELS isolated from immunodeficient rats presenting oral tolerance to dextrin showed increased expression of TGF-beta to reduce the effect of higher levels of inflammatory cytokines.
Olmos
Sofía
S
Department of Biological Sciences, University of Buenos Aires, Buenos Aires, Argentina. olmoss@mail.amc.edu
Marquez
Maria Gabriela
MG
López
María C
MC
Roux
Maria Estela
ME
D000818:Animals; D003912:Dextrins / Q000276:immunology*; D004032:Diet; D004195:Disease Models, Animal; D007108:Immune Tolerance / Q000276:immunology / Q000502:physiology*; D018928:Immunity, Mucosal; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology*; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology; D016211:Transforming Growth Factor alpha / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000276:immunology*
D003912:Dextrins; D016211:Transforming Growth Factor alpha; D016212:Transforming Growth Factor beta; D007371:Interferon-gamma