title: Clinical pharmacology of intraperitoneal cisplatin-based chemotherapy.
abstract: The management of intraperitoneal tumors, especially when confined to the peritoneal cavity and/or associated with malignant ascites, requires the use of intraperitoneal (i.p.) cisplatin-based chemotherapy. This therapeutic approach, enabling high concentrations of drug and long duration of tumor tissue exposure, while generating a systemic exposure similar to that obtained with intravenous (i.v.) infusion, significantly improves therapeutic ratio. Nowadays, as feasibility issues are easy to overcome, intraperitoneal chemotherapy provides a safe, effective treatment for the management of peritoneal disease, particularly ovarian carcinoma. In this paper we review pharmacological issues of intraperitoneal cisplatin-based chemotherapy in order to provide a ready to use information collection for clinical practice and ongoing research.
authors.affiliation: Istituto Oncologico Romagnolo - Laboratory of Clinical Pharmacology and Toxicology, "Santa Maria delle Croci" Hospital, Ravenna, Italy. ra.hotossicologia@ausl.ra.it
authors.forename: M
authors.initials: M
authors.lastname: Conti
authors.forename: U
authors.initials: U
authors.lastname: De Giorgi
authors.forename: V
authors.initials: V
authors.lastname: Tazzari
authors.forename: F
authors.initials: F
authors.lastname: Bezzi
authors.forename: C
authors.initials: C
authors.lastname: Baccini
mesh_terms: D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D006979:Hyperthermia, Induced; D007274:Injections, Intraperitoneal; D010534:Peritoneal Neoplasms / Q000188:drug therapy*
chemical_list: D002945:Cisplatin