Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria.
Rosacea and chronic urticaria are two common skin disorders existing in idiopathic forms. A role of Helicobacter pylori bacterium infection in the aetiopathogenesis of rosacea or chronic urticaria has been suggested although still controversial. The aim of the present study was to establish a relationship between H. pylori infection and rosacea chronic urticaria by means of an immunoproteomic investigation. We analyzed immunoglobulin A (IgA)-, IgG-, and IgE-mediated immune-responses against H. pylori antigens and we identified some bacterial immunoresponsive proteins. A general IgA- and IgE-mediated immune response against antioxidative bacterial proteins was observed. A correlation between the bacterial occurrence and skin diseases pathogenesis is discussed.
Mini
Roberta
R
Dipartimento di Biologia Molecolare, Università degli Studi di Siena, Siena, Italy.
Figura
Natale
N
D'Ambrosio
Chiara
C
Braconi
Daniela
D
Bernardini
Giulia
G
Di Simplicio
Francesca
F
Lenzi
Cristina
C
Nuti
Ranuccio
R
Trabalzini
Lorenza
L
Martelli
Paola
P
Bovalini
Lucia
L
Scaloni
Andrea
A
Santucci
Annalisa
A
D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology*; D002908:Chronic Disease; D004381:Duodenal Ulcer / Q000276:immunology / Q000382:microbiology; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D016481:Helicobacter Infections / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D013058:Mass Spectrometry; D008875:Middle Aged; D020543:Proteome / Q000276:immunology*; D012393:Rosacea / Q000276:immunology* / Q000382:microbiology; D014581:Urticaria / Q000097:blood / Q000276:immunology* / Q000382:microbiology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D020543:Proteome; D007073:Immunoglobulin E