Caenorhabditis elegans PMR1, a P-type calcium ATPase, is important for calcium/manganese homeostasis and oxidative stress response.
The Caenorhabditis elegans PMR1, a P-type Ca2+/Mn2+ ATPase, is expressed in hypodermal seam cells, intestinal cells and spermatheca; localized in Golgi complex. Knock down of pmr-1 as well as overexpression of truncated Caenorhabditis elegans PMR1, which mimics dominant mutations observed in human Hailey-Hailey disease, renders the worm highly sensitive to EGTA and Mn2+. Interestingly, pmr-1 knock down not only causes animals to become resistant to oxidative stress but also suppresses high reactive oxygen species sensitivity of smf-3 RNA-mediated interference and daf-16 worms. These findings suggest that C. elegans PMR1 has important roles in Ca2+ and Mn2+ homeostasis and oxidative stress response.
Cho
Jeong Hoon
JH
Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryoung-dong, Buk-gu, Gwangju 500-712, Korea.
Ko
Kyung Min
KM
Singaravelu
Gunasekaran
G
Ahnn
Joohong
J
D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology* / Q000235:genetics; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000235:genetics / Q000502:physiology*; D004533:Egtazic Acid / Q000494:pharmacology; D006706:Homeostasis / Q000502:physiology*; D008345:Manganese / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D034622:RNA Interference; D014158:Transcription, Genetic
D029742:Caenorhabditis elegans Proteins; C499334:pmr-1 protein, C elegans; D008345:Manganese; D004533:Egtazic Acid; D000252:Calcium-Transporting ATPases; D002118:Calcium