Anti-ribosomal-P antibodies in a Sjögren syndrome patient associated with lupus erythematosus.
We describe a 36-year-old woman who had Sjögren syndrome with anti-ribosomal P antibodies and who developed erythema on her back and arms. The histological specimen showed lymphocytic infiltration around the sweat and salivary glands. Her serum reacted with ribosomal-P0 protein in immunoblotting with HeLa cell extract and P0 recombinant protein. Although autoantibodies to ribosomal-P proteins appear mainly in patients with systemic lupus erythematosus (SLE), a diagnosis of SLE in this patient could not be supported.
Muro
Yoshinao
Y
Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tomita
Yasushi
Y
D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D015800:Protozoan Proteins; D012269:Ribosomal Proteins / Q000276:immunology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D016896:Treatment Outcome
D001323:Autoantibodies; D015415:Biomarkers; C064601:L12E protein, Trypanosoma cruzi; D015800:Protozoan Proteins; D012269:Ribosomal Proteins; D011239:Prednisolone