Oxidative modification of leukocyte adhesion.
In this issue of Immunity, Marko Salmi and colleagues describe mice lacking AOC3, an endothelial cell monoaminooxidase that is involved in modulating leukocyte rolling, adhesion, and migration (Stolen et al., 2005). Their data demonstrate the importance of oxidative modification of (unknown) adhesion molecules in regulating inflammation and lymphocyte homing.
Ley
Klaus
K
Cardiovascular Research Center and Departments of Biomedical Engineering, Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA.
Deem
Tracy L
TL
D006631:Amine Oxidase (Copper-Containing) / Q000502:physiology*; D000818:Animals; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002465:Cell Movement; D007249:Inflammation / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D010084:Oxidation-Reduction
D015815:Cell Adhesion Molecules; D006631:Amine Oxidase (Copper-Containing); C492678:semicarbazide-sensitive amine oxidase-vascular adhesion protein-1, mouse