title: Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase.
abstract: Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2',4'-dibromophenoxy)phenol (1) and 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol (2) were isolated from an extract prepared from Dysidea sp. after bioassay-guided fractionation.
authors.affiliation: Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA.
authors.forename: Ya-ming
authors.initials: YM
authors.lastname: Xu
authors.forename: Randall K
authors.initials: RK
authors.lastname: Johnson
authors.forename: Sidney M
authors.initials: SM
authors.lastname: Hecht
mesh_terms: D000818:Animals; D004987:Ethers / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011075:Polybrominated Biphenyls / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D042787:Receptor, TIE-2 / Q000037:antagonists & inhibitors*
chemical_list: D004987:Ethers; D011075:Polybrominated Biphenyls; D042787:Receptor, TIE-2