Tolerance of aged rat brains to mild hyperoxia: possible involvement of higher GIF content.
We investigate the aging effects of the hyperoxia-mediated induction of two antioxidants and three antioxidant enzymes in the rat brain. All of these genes responded to hyperoxia in young but not aged brains. Despite the partial inactivation of CuZn SOD and glutathione peroxidase by hyperoxia in aged rat brains, lipid peroxidation did not increase. The higher growth inhibitory factor (GIF) content in aged rat brains may be utilized as an antioxidant during hyperoxia.
Gomi
Fujiya
F
Gene Expression Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Tokyo, 173-0015, Japan. gomif@tmig.or.jp
Nakano
Shun-Ichiro
S
Uchida
Yoko
Y
D000367:Age Factors; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D018496:Hyperoxia / Q000378:metabolism*; D008668:Metallothionein / Q000235:genetics / Q000378:metabolism; D000090023:Metallothionein 3; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D013997:Time Factors
D000090023:Metallothionein 3; C491055:Mt2A protein, rat; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D008668:Metallothionein; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D010100:Oxygen