title: Protective effect of taurine against alendronate-induced gastric damage in rats.
abstract: Alendronate (ALD) causes serious gastrointestinal adverse effects. The aim of this study was to investigate whether taurine (TAU), a semi-essential amino acid and an antioxidant, improves the alendronate-induced gastric injury. Rats were administered 20 mg/kg ALD by gavage for 4 days, either alone or following treatment with TAU (50 mg/kg, i.p.). On the last day of treatment, following drug administration, pylorus ligation was performed and 2 h later, rats were killed and stomachs were removed. Gastric acidity and tissue ulcer index values, lipid peroxidation and glutathione (GSH) levels, myeloperoxidase (MPO) activity as well as the histologic appearance of the stomach tissues were determined. Chronic oral administration of ALD induced significant gastric damage, increasing lipid peroxidation, MPO activity and collagen content, as well as decreasing tissue GSH levels. Treatment with TAU prevented the damage and also the changes in biochemical parameters. Findings of the present study suggest that ALD induces oxidative gastric damage by a local irritant effect, and that TAU ameliorates this damage by its antioxidant and/or membrane-stabilizing effects.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Marmara University, Haydarpaşa, 34668, Istanbul, Turkey. gokselsener@hotmail.com
authors.forename: Göksel
authors.initials: G
authors.lastname: Sener
authors.forename: Ozer
authors.initials: O
authors.lastname: Sehirli
authors.forename: Sule
authors.initials: S
authors.lastname: Cetinel
authors.forename: Sükrü
authors.initials: S
authors.lastname: Midillioğlu
authors.forename: Nursal
authors.initials: N
authors.lastname: Gedik
authors.forename: Gül
authors.initials: G
authors.lastname: Ayanoğlu-Dülger
mesh_terms: D019386:Alendronate / Q000009:adverse effects*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D003094:Collagen / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000473:pathology*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013654:Taurine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D013654:Taurine; D008315:Malondialdehyde; D003094:Collagen; D009195:Peroxidase; D005978:Glutathione; D019386:Alendronate