title: The prognostic factor for outcome following second resection for intrahepatic recurrence of hepatocellular carcinoma with a hepatitis B virus infection background.
abstract: OBJECTIVE
  Second resection has been proved to be a safe and effective treatment for patients with intrahepatic recurrent HCC after primary resection; however, preoperative prognostic factors for outcome following second resection in patients with a hepatitis B virus (HBV) infection background remains to be clarified.
  
  
  METHODS
  Fifty-seven patients with intrahepatic recurrent an HCC and HBV infection background received second resection from 1997 to 2003 in our institute. All of them were negative for anti-hepatitis C virus (HCV) and positive regarding HBV profile. Patient and tumor factors were analyzed.
  
  
  RESULTS
  At the time of preparing this paper, 31 had re-recurrence and 21 patients had died. No postoperative mortality was noted. The 1-, 3-, and 5-year overall survival after second resection were 69.9%, 61.2%, and 30.6%, respectively. Univariate and multivariate analysis showed that vascular invasion and time to recurrence were the independent prognostic factors for overall survival following second resection. The 3- and 4-year overall survival after second resection were 57.7% and 46.6% in patients with the presence of any of two risk factors (n = 46), and 100% and 100% in those with absence of both risk factors (n = 11, P = 0.008).
  
  
  CONCLUSIONS
  Vascular invasion and time to recurrence were the prognostic factors for overall survival following second resection of intrahepatic recurrent HCC.
authors.affiliation: Liver Cancer Institute and Zhong Shan Hospital, Fudan University, 200032 Shanghai, PR China.
authors.forename: Hui-Chuan
authors.initials: HC
authors.lastname: Sun
authors.forename: Zhao-You
authors.initials: ZY
authors.lastname: Tang
authors.forename: Zeng-Chen
authors.initials: ZC
authors.lastname: Ma
authors.forename: Lun-Xiu
authors.initials: LX
authors.lastname: Qin
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Qin-Hai
authors.initials: QH
authors.lastname: Ye
authors.forename: Jia
authors.initials: J
authors.lastname: Fan
authors.forename: Zhi-Quan
authors.initials: ZQ
authors.lastname: Wu
authors.forename: Xin-Da
authors.initials: XD
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000401:mortality / Q000601:surgery*; D005260:Female; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome