Antimicrobial activity of N-alkoxycarbonylmethyl-N-alkyl-piperidinium chlorides.
The aim of the study was to assay antibacterial and antifungal activity of newly synthesised N-alkoxycarbonylmethyl-N-alkyl-piperidinium chlorides. The compounds tested were found to inhibit the growth of some Gram-negative bacteria, Gram-positive strains and some representatives of yeast-type Candida. From microbiological experiments two of the compounds tested, N-dodecyloxycarbonylmethyl-N-methyl-piperidinium chloride (3) and N-dodecyl-N-ethoxycarbonylmethyl-piperidinium chloride (6), emerged as more active than the other compounds. Since the resistance of biofilms to biocides should be noted during the design and testing of new antimicrobial agents therefore, we have analysed antibacterial properties of the most active compounds towards biofilms. Our study focused on strains of Pseudomonas aeruginosa and Staphylococcus aureus that served as main model organisms for the biofilm studies.
Woźniak
Edyta
E
Department of Physics and Biophysics, Agricultural University, Norwida 25, 50-375 Wrocław, Poland. GUCIO@OZI.AR.WROC.PL
Mozrzymas
Anna
A
Czarny
Anna
A
Kocieba
Maja
M
Rózycka-Roszak
Bozenna
B
Dega-Szafran
Zofia
Z
Dulewicz
Ewa
E
Petryna
Magdalena
M
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011760:Pyrrolidinones / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D010880:Piperidines; D011760:Pyrrolidinones