Paraneoplastic neurologic syndrome and autoimmune Addison disease in a patient with thymoma.
A 48-year-old man with autoimmune Addison disease developed the following paraneoplastic neurologic syndromes (PNNS): limbic encephalitis, opsoclonus/myoclonus, and sensorimotor and autonomic neuropathies. An anterior mediastinal mass detected on a chest computed tomographic scan was found on resection to be a noninvasive lymphocytic thymoma. The PNNS went into remission 1 year after the thymectomy. This is the first case of thymoma associated with autoimmune Addison disease and PNNS to be described in the literature.
Morita
Hiroyuki
H
Department of General Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan. hmorita@cc.gifu-u.ac.jp
Hirota
Takuo
T
Mune
Tomoatsu
T
Suwa
Tetsuya
T
Ishizuka
Tatsuo
T
Inuzuka
Takashi
T
Tanaka
Keiko
K
Ishimori
Masatoshi
M
Nakamura
Shigenori
S
Yasuda
Keigo
K
D000224:Addison Disease / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020361:Paraneoplastic Syndromes, Nervous System / Q000209:etiology*; D013945:Thymoma / Q000150:complications*; D013953:Thymus Neoplasms / Q000150:complications*