A new [2 + 2] photodimerization of 5-chloro- and 5-methyl-2-pyridone in their inclusion complexes with 1,1'-biphenyl-2,2'-dicarboxylic acid as a model for DNA damage by photodimerization of its thymine component.
As a model for DNA damage by photodimerization of its thymine component, a new [2 + 2] photodimerization of 5-chloro and 5-methyl-2-pyridone to the corresponding cis-anti-dimers as their inclusion complexes with 1,1'-biphenyl-2,2'-dicarboxylic acid was found, and the mechanism of this stereoselective solid state reaction was studied by X-ray analysis.
Hirano
Shinya
S
Department of Chemistry, Faculty of Science, Okayama University of Science, Ridai-cho 1-1, Okayama 700-0005, Japan.
Toyota
Shinji
S
Toda
Fumio
F
D001713:Biphenyl Compounds / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004249:DNA Damage; D019281:Dimerization; D046911:Macromolecular Substances / Q000737:chemistry; D008954:Models, Biological; D008956:Models, Chemical; D015394:Molecular Structure; D010777:Photochemistry; D011728:Pyridones / Q000737:chemistry*; D013237:Stereoisomerism; D013941:Thymine / Q000737:chemistry*
D001713:Biphenyl Compounds; D046911:Macromolecular Substances; D011728:Pyridones; C510368:5-methyl-2-pyridone; D013941:Thymine; C039204:diphenic acid; C510367:5-chloro-2-pyridone