Bioactive ellagitannins from Cunonia macrophylla, an endemic Cunoniaceae from New Caledonia.
Chemical study of Cunonia macrophylla, a New Caledonian Cunoniaceae, based on bioactive effects of a crude methanol extract of the leaves, detected bioactive tannins for the first time in this plant family. These ellagitannins have been identified as ellagic acid-4-O-beta-D-xylopyranoside (6), mallorepanin (3), mallotinic acid (1) along with corilagin (2), chebulagic acid (4), ellagic acid (5) and gallic acid (7) and have been shown to possess antimicrobial activity and to inhibit xanthine oxidase. Antimicrobial effects on bacterial human pathogens (Staphylococcus aureus, Corynebacterium accolans) and on a plant pathogen (Erwinia carotovora) as well as on a human pathogenic yeast (Candida albicans) were investigated. Activity is reported here for the first time for compounds 1, 3, 4 and 6. The inhibitory effects of all molecules against xanthine oxidase in relation to their structure was evaluated and compared. Compound 6 presented the best activity and seems to be of considerable interest for further studies.
Fogliani
Bruno
B
Laboratoire de Biologie et Physiologie Végétales Appliquées (L.B.P.V.A.), Université de la Nouvelle-Calédonie, BP 4477, 98847 Nouméa, Nouvelle-Calédonie. bfoglian@univ-nc.nc
Raharivelomanana
Phila
P
Bianchini
Jean-Pierre
JP
Bouraïma-Madjèbi
Saliou
S
Hnawia
Edouard
E
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D003352:Corynebacterium / Q000187:drug effects; D004885:Erwinia / Q000187:drug effects; D047348:Hydrolyzable Tannins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009510:New Caledonia; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D000890:Anti-Infective Agents; D047348:Hydrolyzable Tannins; D014969:Xanthine Oxidase