A new therapeutic challenge for old pathogens: community-acquired invasive infections caused by ceftriaxone- and ciprofloxacin-resistant Salmonella enterica serotype choleraesuis.
Recently, antimicrobial resistance among nontyphoid Salmonella serotypes has been increasingly recognized. In southern Taiwan, we encountered 3 cases of invasive infections caused by Salmonella enterica serotype Choleraesuis with resistance to ciprofloxacin and ceftriaxone. Resistance to ciprofloxacin was related to nucleotide mutations in gyrA and parC, and resistance to ceftriaxone was related to the presence of CMY-2 beta -lactamase.
Ko
Wen-Chien
WC
Department of Medicine, National Cheng Kung University Medical College, Taiwan.
Yan
Jing-Joung
JJ
Yu
Wen-Liang
WL
Lee
Hsin-Chun
HC
Lee
Nan-Yao
NY
Wang
Li-Rong
LR
Chuang
Yin-Ching
YC
D000328:Adult; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D002443:Ceftriaxone / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology*; D027081:DNA Gyrase; D027101:DNA Topoisomerase IV; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012475:Salmonella / Q000187:drug effects* / Q000235:genetics; D012480:Salmonella Infections / Q000188:drug therapy / Q000382:microbiology*; D013624:Taiwan / Q000453:epidemiology; D001618:beta-Lactamases
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D002443:Ceftriaxone; C103022:beta-lactamase CMY-2; D001618:beta-Lactamases; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase