Effect of NO synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine on endotoxin-induced changes in hemodynamic parameters and respiration in rats.
We studied the effect of NO synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine (2-ADT) on the cardiovascular system in rats with endotoxic shock. Blood pressure, heart rate, and respiratory rate were recorded. E. coli lipopolysaccharide decreased blood pressure and heart rate. 2-ADT in a dose of 5 mg/kg normalized these hemodynamic parameters. The normalizing effect of 2-ADT decreased with increasing the dose of this preparation. 2-ADT in high doses (10, 20, and 30 mg/kg) and repeated injections of the preparation caused death of experimental animals.
Proskuryakov
S Ya
SY
Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. pros@mrrc.obninsk.ru
Filimonova
M V
MV
Verkhovskii
Yu G
YG
Konoplyannikov
A G
AG
Mandrugin
A A
AA
Fedoseev
V M
VM
Skvortsov
V G
VG
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000633:toxicity; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects*; D012772:Shock, Septic / Q000188:drug therapy* / Q000503:physiopathology; D013843:Thiazines / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity
D004731:Endotoxins; D004791:Enzyme Inhibitors; D013843:Thiazines; C018450:2-amino-5,6-dihydro-4H-1,3-thiazine; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; C496318:Nos2 protein, rat; C496316:Nos3 protein, rat