Early upregulation of T cell IL-10 production plays an important role in oral tolerance induction.
Early in oral tolerance induction, IL-10-producing CD4(+) T cells were increased, and adoptive transfer of IL-10-deficient CD4(+) T cells failed induction of oral tolerance, suggesting a key role of IL-10 production in such a process.
Cong
Y
Y
Division of Gastroenterology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. ycong@uab.edu
Liu
C
C
Weaver
C T
CT
Elson
C O
CO
D000284:Administration, Oral; D019264:Adoptive Transfer; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D007108:Immune Tolerance; D018928:Immunity, Mucosal; D016753:Interleukin-10 / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell; D013601:T-Lymphocytes / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell; D016753:Interleukin-10; D010047:Ovalbumin