title: Enantiomerical excess determination, purification and biological evaluation of (3S) and (3R) alpha,beta-butenolide analogues of isobenzofuranone.
abstract: The asymmetric synthesis of isobenzofurane analogues, new potential antiviral agents, is reported. High performance liquid chromatography (HPLC) was the technique chosen to separate the enantiomers. We describe this chiral separation and then determine the enantiomerical excess. The biological results of each tested enantiomer are given.
authors.affiliation: Laboratoire de Chimie Analytique EA 1043, Université de Lille 2, BP 83-3, rue du Pr. Laguesse, 59006 Lille, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Lipka
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Vaccher
authors.forename: Claude
authors.initials: C
authors.lastname: Vaccher
authors.forename: Christophe
authors.initials: C
authors.lastname: Len
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D001572:Benzofurans