title: Broad analgesic profile of buprenorphine in rodent models of acute and chronic pain.
abstract: Buprenorphine is a potent opioid analgesic clinically used to treat moderate to severe pain. The present study assessed its analgesic efficacy in a broad range of rodent models of acute and chronic pain. In the phenylquinone writhing, hot plate, and tail flick mouse models of acute pain, full analgesic efficacy was obtained (ED50 values: 0.0084-0.16 mg/kg i.v.). Full analgesic efficacy was also obtained in yeast- and formalin-induced inflammatory pain (ED50 values: 0.0024-0.025 mg/kg i.v., rats and mice) and in mustard-oil-induced spontaneous pain, referred allodynia, and referred hyperalgesia in mice (ED50 values: 0.018-0.025 mg/kg i.v.). Buprenorphine strongly inhibited mechanical and cold allodynia in mononeuropathic rats, as well as mechanical hyperalgesia and cold allodynia in polyneuropathic rats (ED50 values: 0.055 and 0.036 mg/kg i.v. and 0.129 and 0.038 mg/kg i.p., respectively). It is concluded that buprenorphine shows a broad analgesic profile and offers the opportunity to treat different pain conditions, including neuropathic pain.
authors.affiliation: Department of Pharmacology, Grünenthal GmbH Research and Development, Zieglerstrasse 6, D-52078 Aachen, Germany. thomas.christoph@grunenthal.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Christoph
authors.forename: Babette
authors.initials: B
authors.lastname: Kögel
authors.forename: Klaus
authors.initials: K
authors.lastname: Schiene
authors.forename: Murielle
authors.initials: M
authors.lastname: Méen
authors.forename: Jean
authors.initials: J
authors.lastname: De Vry
authors.forename: Elmar
authors.initials: E
authors.lastname: Friderichs
mesh_terms: D000208:Acute Disease; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000818:Animals; D002047:Buprenorphine / Q000008:administration & dosage*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine