Development of a novel prolonged-release nicotine transdermal patch.
A transdermal patch for delivering nicotine for periods of 12-48h was designed. An inclusion complex formed between the nicotine and beta-cyclodextrine (beta-CD) was used in drug depot. The usefulness of a specially cross-linked polyvinyl alcohol (cross-PVA) membrane was investigated as a rate controlling membrane. The influence of carbopol polymers, type C-934P and C-940 and propylene glycol on transdermal permeation of nicotine through the rat skin was investigated. The results indicated a maximum flux of 42 microgcm(-2)h(-1) after 48 h from the patches made from C-934P when the propylene glycol concentration was 15% and the nicotine-beta-CD mole ratio in the inclusion complex was 3:1. These nicotine transdermal patches can be fabricated to obtain a controlled release, zero order systems.
Davaran
Soodabeh
S
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Rashidi
Mohammad R
MR
Khandaghi
Reza
R
Hashemi
Mahdi
M
D000279:Administration, Cutaneous; D000818:Animals; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009538:Nicotine / Q000008:administration & dosage* / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption / Q000187:drug effects* / Q000502:physiology
D003692:Delayed-Action Preparations; D009538:Nicotine