title: [Host defense mechanisms against Salmonella infection].
abstract: Salmonella is one of the gram negative intracellular pathogens. The immune response to Salmonella includes innate immunity and adaptive immunity. The intestinal epithelium, neutrophil, macrophage, dendritic cell, NK cell, NK T cell and gammadelta T cell take important part in former process, and antigen specific T cell and B cell take part in the later process. Macrophages and dendritic cells increase in number early after Salmonella infection and produce variety of cytokines. Especially, IL-12, IL-15 and IL-18 play important roles in protection against Salmonella infection, proliferation of NK cell, NKT cell and gammadelta T cell, producing IFN-gamma, in addition, IL-12 and IL-18 induce IFN-gamma production by Th1 cells and adaptive immune response.
authors.affiliation: Department of Pediatric Infectious Diseases, Fukuoka Children's Hospital and Medical Center for Infectious Diseases.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Mizuno
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D051379:Mice; D012480:Salmonella Infections / Q000276:immunology*