title: Antimicrobial activity of N-alkoxycarbonylmethyl-N-alkyl-piperidinium chlorides.
abstract: The aim of the study was to assay antibacterial and antifungal activity of newly synthesised N-alkoxycarbonylmethyl-N-alkyl-piperidinium chlorides. The compounds tested were found to inhibit the growth of some Gram-negative bacteria, Gram-positive strains and some representatives of yeast-type Candida. From microbiological experiments two of the compounds tested, N-dodecyloxycarbonylmethyl-N-methyl-piperidinium chloride (3) and N-dodecyl-N-ethoxycarbonylmethyl-piperidinium chloride (6), emerged as more active than the other compounds. Since the resistance of biofilms to biocides should be noted during the design and testing of new antimicrobial agents therefore, we have analysed antibacterial properties of the most active compounds towards biofilms. Our study focused on strains of Pseudomonas aeruginosa and Staphylococcus aureus that served as main model organisms for the biofilm studies.
authors.affiliation: Department of Physics and Biophysics, Agricultural University, Norwida 25, 50-375 Wrocław, Poland. GUCIO@OZI.AR.WROC.PL
authors.forename: Edyta
authors.initials: E
authors.lastname: Woźniak
authors.forename: Anna
authors.initials: A
authors.lastname: Mozrzymas
authors.forename: Anna
authors.initials: A
authors.lastname: Czarny
authors.forename: Maja
authors.initials: M
authors.lastname: Kocieba
authors.forename: Bozenna
authors.initials: B
authors.lastname: Rózycka-Roszak
authors.forename: Zofia
authors.initials: Z
authors.lastname: Dega-Szafran
authors.forename: Ewa
authors.initials: E
authors.lastname: Dulewicz
authors.forename: Magdalena
authors.initials: M
authors.lastname: Petryna
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011760:Pyrrolidinones / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D010880:Piperidines; D011760:Pyrrolidinones