title: Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice.
abstract: Y-700, 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid, is a newly synthesized inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer.
authors.affiliation: Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Fukunari
authors.forename: Ichimaro
authors.initials: I
authors.lastname: Yamada
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Yanaka
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.forename: Norihisa
authors.initials: N
authors.lastname: Kato
mesh_terms: D019813:1,2-Dimethylhydrazine; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D003106:Colon / Q000473:pathology; D003108:Colonic Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011720:Pyrazoles / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: C433950:1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid; D011720:Pyrazoles; D014969:Xanthine Oxidase; D019813:1,2-Dimethylhydrazine