[Clinical effectiveness of ropivacaine mesylate in epidural anesthesia and postoperative analgesia].
OBJECTIVE
To compare the clinical effectiveness of ropivacaine mesylate and ropivacaine hydrochloride in epidural anesthesia and postoperative analgesia.


METHODS
Forty-four patients undergoing epidural anesthesia for intraperitoneal hysterectomy or hysteromyomectomy were randomly assigned to two equal groups. Group ropivacaine hydrochloride received 15 ml ropivacaine hydrochloride of 7.5 mg/ml in anesthetic and 2 mg/ml in postoperative analgesic subsequently while group ropivacaine mesylate correspondingly received ropivacaine mesylate of both 15 ml of 8.94 mg/ml and 2.374 mg/ml.


RESULTS
No significant differences were found in the onset, extent, and duration of sensory and motor blockage, and also in the hemodynamic stability, when ropivacaine mesylate was comparable with ropivacaine hydrochloride. No severe adverse events were observed in this study.


CONCLUSIONS
Ropivacaine mesylate is an effective and safe alternative to ropivacaine hydrochloride in epidural anesthesia and postoperative analgesia.
Xu
Jian-Qing
JQ
Department of Anesthesiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. jqxu@163bj.com
Zhu
Bo
B
Ye
Tie-Hu
TH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000577:Amides / Q000737:chemistry / Q000627:therapeutic use; D000767:Anesthesia, Epidural; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D000077212:Ropivacaine
D000577:Amides; D000077212:Ropivacaine