title: A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population.
abstract: Studies have shown a strong positive association between schizophrenia and G72/G30, demonstrated by both individual markers and haplotypes. A further functional study also supports the role of G72 in the etiology of schizophrenia. In this study, we have replicated these results of transmission/disequilibrium testing (TDT) and haplotype analysis in the Han Chinese population, showing P values of 0.0018 and 0.00007 for individual markers and haplotypes, respectively. Hence, our data supports the hypothesis that G72/G30 are important candidate genes for explaining schizophrenia in the Han Chinese population.
authors.affiliation: Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai 200031, PR China.
authors.forename: Fanggeng
authors.initials: F
authors.lastname: Zou
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
authors.forename: Yonglan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Niufan
authors.initials: N
authors.lastname: Gu
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Yangling
authors.initials: Y
authors.lastname: Xing
authors.forename: Jianguo
authors.initials: J
authors.lastname: Shi
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002681:China; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D015810:Linkage Disequilibrium; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; C475071:DAOA protein, human; C488199:DAOAAS gene product, human; D005819:Genetic Markers; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D012333:RNA, Messenger