title: [Second-line chemotherapy for advanced colorectal cancer].
abstract: Chemotherapy for advanced colorectal cancer is much improved in this decade. Biochemical modulation and multi-drug therapies, such as FOLFOX, FORFIRI and IFL, contributed to higher response rate and prolonged patient's survival. It was recommended to administer oxaliplatin with 5-FU and leucovorin in first line chemotherapy and CPT-11 for the second line, or in reverse sequence. 5-FU+l-LV and UFT+LV are still common first line therapies and CPT-11 as a second line in Japan, as oxaliplatin, capecitabine and molecular target agents are not available. Physicians should consider maintaining good QOL of the patient, as well as tumor shrinkage and prolonged survival, in second line chemotherapy.
authors.affiliation: Dept. of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uetake
authors.forename: Satoru
authors.initials: S
authors.lastname: Iida
authors.forename: Hidehumi
authors.initials: H
authors.lastname: Tsunozaki
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Higuchi
authors.forename: Masamichi
authors.initials: M
authors.lastname: Yasuno
authors.forename: Masayuki
authors.initials: M
authors.lastname: Enomoto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D002955:Leucovorin / Q000008:administration & dosage; D011788:Quality of Life; D015996:Survival Rate; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C096910:UFT(R) drug; D005641:Tegafur; D014498:Uracil; D000077146:Irinotecan; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin