The mammalian Mediator complex.
The multiprotein Mediator (Med) complex is an evolutionarily conserved transcriptional regulator that plays important roles in activation and repression of RNA polymerase II transcription. Prior studies identified a set of more than twenty distinct polypeptides that compose the Saccharomyces cerevisiae Mediator. Here we discuss efforts to characterize the subunit composition and associated activities of the mammalian Med complex.
Conaway
Joan Weliky
JW
Stowers Institute for Medical Research, Kansas City, MO 64110, USA. jlc@stowers-institute.org
Florens
Laurence
L
Sato
Shigeo
S
Tomomori-Sato
Chieri
C
Parmely
Tari J
TJ
Yao
Tingting
T
Swanson
Selene K
SK
Banks
Charles A S
CA
Washburn
Michael P
MP
Conaway
Ronald C
RC
D000818:Animals; D008322:Mammals / Q000378:metabolism; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism; D021122:Protein Subunits; D040901:Proteomics; D015534:Trans-Activators / Q000737:chemistry* / Q000378:metabolism*
D046912:Multiprotein Complexes; D021122:Protein Subunits; D015534:Trans-Activators