Diagnostic value of a peroral sucrose permeability test in children with recurrent upper abdominal pain.
The access of ingested sucrose into blood and urine indicates the presence of mucosal lesions in the upper gastrointestinal tract. The study involved 42 children, aged 5-15, having recurrent upper abdominal pain and 43 peers with minor extra-abdominal complaints. Sucrose in urine was determined by thin layer chromatography. The test was positive in 27 out of 42 children having recurrent abdominal pain (64.3%) and in none of the control children (chi2 = 37.6, p < 0.0001). When correlated with endoscopic findings it was falsely negative in 12 out of 38 patients with endoscopically verified lesions of the stomach or duodenum and falsely positive in 1 out of 4 without lesions. Sensitivity of the test was 68.4%, specificity 97.9%, positive predictive value 96.3%. The test cannot be used as an alternative to endoscopy, but may serve for screening of candidates for it.
Pinotić
Ljerka
L
Department of Pediatrics, Clinical Hospital Osijek, Croatia. ljerka.pinotic@os.htnet.hr
Zecić-Fijacko
Mirjana
M
Vcev
Aleksandar
A
Paulini
Dubravko
D
Mihaljević
Silvije
S
Horvat
Darko
D
Mandić
Zlatko
Z
Votava-Raić
Ana
A
Boranić
Milivoj
M
D015746:Abdominal Pain / Q000209:etiology*; D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016099:Endoscopy, Gastrointestinal; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008297:Male; D010539:Permeability; D011237:Predictive Value of Tests; D012008:Recurrence; D012680:Sensitivity and Specificity; D013395:Sucrose / Q000008:administration & dosage / Q000652:urine*; D013549:Sweetening Agents / Q000008:administration & dosage / Q000032:analysis*
D013549:Sweetening Agents; D013395:Sucrose