Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in Chilean subjects: a case-parent study.
Several reports have found a relation between polymorphisms of the vitamin D receptor gene (VDR) and the development of type 1 diabetes. We have examined the association of three VDR polymorphism with type 1 diabetes in 59 Chilean case-parents trios. Genotyping for Bsm1, Apal and Taq1 polymorphism were performed. Transmission/ disequiibrium tests were used to assess gene-disease associations through the evaluation of allelic transmission to affected offspring. Non-significant increased transmissions of B allele (probability of transmission = 52.5%, p = 0.69), A allele (probability of transmission = 58.4%, p = 0.17) and T allele (probability of transmission = 52.0%, p = 0.77) were estimated in Bsml, Apal and Taql sites, respectively. Haplotype-based analyses showed non-significant preferential transmissions (global p = 0.52). The present study does not support the hypothesis of a significant contribution of VDR alleles in the etiology of type 1 diabetes of Chilean cases.
Angel
Barbara
B
Genetics Epidemiology Laboratory, Nutrition and Food Technology Institute (INTA), University of Chile, Santiago, Chile.
Santos
José Luis
JL
Carrasco
Elena
E
Albala
Cecilia
C
Pérez-Bravo
Francisco
F
D000293:Adolescent; D017668:Age of Onset; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007223:Infant; D015810:Linkage Disequilibrium; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol