Animal models of arthritis. What have we learned?
Animal models of arthritis can be used to understand elements of the arthritic process in patients. Recent therapeutic approaches in patients with rheumatoid arthritis (RA) with biologics are based on initial findings in murine models of experimental arthritis, although final proof of concept must come from clinical studies. Animal models are powerful tools for studying pathologic changes in articular cartilage and bone in great detail, and can be used to evaluate mechanisms of erosive processes. Although in general more inflammation drives more destruction, the uncoupling of inflammation and erosion can be seen as well, and different mediators are involved in these processes.
van den Berg
Wim B
WB
Rheumatology Research and Advanced Therapeutics Unit, University Medical Center St. Radboud, 6500 HB Nijmegen, The Netherlands. W.vandenBerg@reuma.umcn.nl
D000818:Animals; D001172:Arthritis, Rheumatoid; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D006801:Humans; D051379:Mice
D016207:Cytokines