Trypanocidal activity of extracts and fractions of Bertholletia excelsa.
Crude extracts and fractions of Bertholletia excelsa stem barks were tested for trypanocidal activity. Acetone and methanol extracts showed significant in vitro trypanocidal activity against trypomastigote form of Trypanosoma cruzi since in the concentration of 500 microg/ml, the parasites were reduced in 100% and 90.3% respectively, whereas the triterpene betulinic acid pure isolated from hexane extract presented 75.4%.
Campos
Francinete R
FR
Departamento de Química, Universidade do Amazonas UA, Av. Gal. Otávio Rodrigo Jordão Ramos, 3000 69077-000 Manaus AM, Brazil.
Januário
Ana H
AH
Rosas
Lisandra V
LV
Nascimento
Samara K R
SK
Pereira
Paulo S
PS
França
Suzelei C
SC
Cordeiro
Milade S C
MS
Toldo
Miriam P A
MP
Albuquerque
Sérgio
S
D000818:Animals; D031383:Bertholletia; D014355:Chagas Disease / Q000188:drug therapy / Q000469:parasitology; D051379:Mice; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
D010936:Plant Extracts; D014344:Trypanocidal Agents