Cholesterol selectively enhances in vitro latex-specific IgE production in atopic dermatitis patients with latex allergy.
Effect of cholesterol on in vitro latex-specific IgE production by mononuclear cells from atopic dermatitis patients with latex allergy. Cholesterol enhanced latex-specific IgE production in a dose-dependent fashion, and maximal enhancement was achieved at 1 microg/ml. In contrast, cholesterol had no effect on latex -specific IgA or IgG4 production. Study for cytokine production revealed that cholesterol decreased latex-induced production of IFN-gamma and IL-12, while it increased latex-induced production of IL-4, IL-10 and IL-13. These results indicate that cholesterol skews cytokine pattern toward Th2 type. Collectively, cholesterol may increase allergen-specific IgE production, which may in turn aggravate allergic symptoms.
Kimata
Hajime
H
Department of Allergy, Satou Hospital, Hirakata City, Osaka Prefecture 573-1124, Japan. kimata@misugikai.jp
D000918:Antibody Specificity; D002478:Cells, Cultured; D002784:Cholesterol / Q000494:pharmacology*; D016207:Cytokines / Q000096:biosynthesis; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology; D007840:Latex / Q000276:immunology; D020315:Latex Hypersensitivity / Q000276:immunology* / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D011092:Polyethylene Glycols / Q000494:pharmacology
D016207:Cytokines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007840:Latex; D007073:Immunoglobulin E; D011092:Polyethylene Glycols; D002784:Cholesterol