title: Role of open lung biopsy in patients with diffuse lung infiltrates and acute respiratory failure.
abstract: OBJECTIVE
  Open lung biopsy (OLB) is the standard procedure for the diagnosis of specific parenchymal lung diseases. The purpose of this study was to investigate the influence of OLB on subsequent treatment strategy and outcome in patients with diffuse lung infiltrates and acute respiratory failure.
  
  
  METHODS
  This retrospective review included 32 patients (aged 50.6 +/- 21.7 years) with acute respiratory failure and diffuse pulmonary infiltrates who underwent OLB from 1990-2002. Data analyzed included diagnoses, treatment alterations, 30-day survival, oxygenation status, and histologic results.
  
  
  RESULTS
  Specific diagnoses were made in 53.1% of patients (17/32), 23 (71.9%) of whom had acute respiratory distress syndrome (ARDS). Diagnostic yields did not differ with immunity status or ARDS. OLB led to specific decisions of treatment in 46.9% of patients (15/32), and only 7 of these 32 patients (21.8%) survived. Overall mortality was 56.2% (18/32) and was not influenced by pre-OLB oxygenation or histologic results. Although perioperative complications affected 40.6% of patients (13/32), none of the deaths were surgery-related. Complication rates were significantly higher in patients with ARDS (p = 0.04).
  
  
  CONCLUSIONS
  OLB is associated with a low perioperative mortality rate and acceptable morbidity rate in patients with diffuse lung infiltrates and acute respiratory failure, including those patients with ARDS. In this study, a specific diagnosis was obtained by OLB in more than half of patients with diffuse pulmonary infiltrates and ARDS. In addition, OLB resulted in either use of a new therapeutic strategy or elimination of unnecessary treatment in nearly one-half of patients (46.9%).
authors.affiliation: Division of Pulmonary Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Nei-Hu, Taipei, Taiwan.
authors.forename: Li-Hui
authors.initials: LH
authors.lastname: Soh
authors.forename: Chih-Feng
authors.initials: CF
authors.lastname: Chian
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Su
authors.forename: Horng-Chin
authors.initials: HC
authors.lastname: Yan
authors.forename: Wann-Cherng
authors.initials: WC
authors.lastname: Perng
authors.forename: Chin-Pyng
authors.initials: CP
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000009:adverse effects; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000473:pathology*; D012131:Respiratory Insufficiency / Q000473:pathology*; D012189:Retrospective Studies