title: Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years.
abstract: BACKGROUND
  Data on mature T-cell and natural killer (NK)-cell lymphomas diagnosed with the World Health Organization (WHO) classification scheme are scarce. They are regarded to be more common in Asian populations.
  
  
  METHODS
  Consecutive T-cell and NK-cell lymphomas classified according to the WHO scheme within 10 years in a Chinese population were reviewed.
  
  
  RESULTS
  There were 148 cases, constituting 16.6% (T-cell, n=90, 10.1%, NK-cell, n=58, 6.5%) of all non-Hodgkin lymphomas in this period. There was a male predominance (male:female = 2.5), young age at diagnosis (median age 50 years, range 8-86) and frequent extranodal presentation. Commonest T-cell lymphomas included anaplastic large cell lymphoma (ALCL, n=25, median age 35 years, nodal 60%, stage I/II 60%), peripheral T-cell lymphoma, unspecified (PTCL, n=24, median age 54 years, nodal 42%, stage I/II 42%), and angioimmunoblastic T-cell lymphoma (AILT, n=19, median age 67 years, nodal 95%, stage I/II 26%). Overall frequencies of T-cell lymphomas were comparable to Western patients. AILT, PTCL and ALCL were aggressive with a poor outcome. NK-cell lymphomas were predominantly extranodal (96%) and aggressive, with a frequency much higher than Western patients.
  
  
  CONCLUSIONS
  The apparent high prevalence of T-cell and NK-cell lymphomas in the Chinese was due to more frequent NK-cell but not T-cell lymphomas.
authors.affiliation: University Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, ROC.
authors.forename: W-Y
authors.initials: WY
authors.lastname: Au
authors.forename: S-Y
authors.initials: SY
authors.lastname: Ma
authors.forename: C-S
authors.initials: CS
authors.lastname: Chim
authors.forename: C
authors.initials: C
authors.lastname: Choy
authors.forename: F
authors.initials: F
authors.lastname: Loong
authors.forename: A K W
authors.initials: AK
authors.lastname: Lie
authors.forename: C C K
authors.initials: CC
authors.lastname: Lam
authors.forename: A Y H
authors.initials: AY
authors.lastname: Leung
authors.forename: E
authors.initials: E
authors.lastname: Tse
authors.forename: C-C
authors.initials: CC
authors.lastname: Yau
authors.forename: R
authors.initials: R
authors.lastname: Liang
authors.forename: Y-L
authors.initials: YL
authors.lastname: Kwong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002681:China; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural; D016399:Lymphoma, T-Cell / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012737:Sex Factors; D016019:Survival Analysis; D016896:Treatment Outcome