Serum oxidant/antioxidant balance in exfoliation syndrome.
BACKGROUND
To evaluate the relationship between the serum oxidant-antioxidant balance and the presence of exfoliation syndrome (XFS) in a prospective study.


METHODS
The study group comprised 27 cases of XFS. Serum concentrations of myeloperoxidase, malondialdehyde, vitamins A, C and E, catalase and total antioxidant were measured and compared with an independent group by t-test.


RESULTS
Serum myeloperoxidase, vitamins A and E, catalase and total antioxidant parameters were not statistically different among the groups (P >0.05). Serum vitamin C concentrations were significantly lower and malondialdehyde concentrations were significantly higher in cases of XFS when compared with the control group (P=0.008 and P=0.002, respectively).


CONCLUSIONS
An altered oxidant-antioxidant balance may play a role in the pathogenesis of XFS.
Yimaz
Ayça
A
Department of Ophthalmology, Mersin University Faculty of Medicine, Mersin, Turkey.
Adigüzel
Ufuk
U
Tamer
Lülüfer
L
Yildirim
Ozlem
O
Oz
Ozay
O
Vatansever
Halil
H
Ercan
Bahadir
B
Değirmenci
Ula S
US
Atik
Uğur
U
D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood*; D002374:Catalase / Q000097:blood*; D017889:Exfoliation Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000097:blood*; D011446:Prospective Studies; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
D000975:Antioxidants; D014801:Vitamin A; D014810:Vitamin E; D008315:Malondialdehyde; D002374:Catalase; D009195:Peroxidase; D001205:Ascorbic Acid