title: N-acetyltransferase 2 polymorphisms in patients with Behcet's disease.
abstract: It is possible that dietary, environmental factors and/or genetic polymorphisms in xenobiotic-metabolizing enzymes may contribute to the development of Behcet's disease. As N-acetyltransferase (NAT) 2 is an important xenobiotic-metabolizing enzyme and theoretically the nonacetylated xenobiotics may induce an autoimmune mechanism, the aim of the present study was to investigate whether the genetic polymorphism of NAT2 plays a role in susceptibility to Behcet's disease. Forty Behcet's disease patients and 82 control subjects were enrolled in the study. NAT2*5A, NAT2*6A, NAT27*A/B and NAT2*14A polymorphisms were detected by using real time PCR with LightCycler (Roche Diagnostics GmbH, Mannheim, Germany). The NAT2*5A and NAT2*6A mutant genotypes carried an increased risk of developing Behcet's disease [odds ratio (OR) = 66.29, 95% confidence interval (CI) = 8.21-535.33; and OR = 24; 95% CI = 2.04-304.98, respectively]. The NAT2*7A/B and NAT2*14A gene polymorphisms were not an increased risk for developing Behcet's disease. As a result of this study we conclude the NAT2 slow acetylator status may be a determinant in susceptibility to Behcet's disease. This finding may have implications for the theories of the pathogenesis of the disease as well as for therapeutic aspects.
authors.affiliation: Department of Biochemistry, Mersin University, Turkey. lutamer@yahoo.com
authors.forename: L
authors.initials: L
authors.lastname: Tamer
authors.forename: U
authors.initials: U
authors.lastname: Tursen
authors.forename: G
authors.initials: G
authors.lastname: Eskandari
authors.forename: N A
authors.initials: NA
authors.lastname: Ates
authors.forename: B
authors.initials: B
authors.lastname: Ercan
authors.forename: H
authors.initials: H
authors.lastname: Yildirim
authors.forename: U
authors.initials: U
authors.lastname: Atik
mesh_terms: D000107:Acetylation; D000328:Adult; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D001528:Behcet Syndrome / Q000201:enzymology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D001191:Arylamine N-Acetyltransferase