The anaphase-promoting complex: a key factor in the regulation of cell cycle.
Events controlling cell division are governed by the degradation of different regulatory proteins by the ubiquitin-dependent pathway. In this pathway, the attachment of a polyubiquitin chain to a substrate by an ubiquitin-ligase targets this substrate for degradation by the 26S proteasome. Two different ubiquitin ligases play an important role in the cell cycle: the SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC). In this review, we describe the present knowledge about the APC. We pay particular attention to the latest results concerning APC structure, APC regulation and substrate recognition, and we discuss the implication of these findings in the understanding the APC function.
Castro
Anna
A
Centre de Recherche de Biochimie Macromoléculaire, CNRS FRE 2593 1919 Route de Mende, 34293 Montpellier cedex 5, France. castro@crbm.cnrs-mop.fr
Bernis
Cyril
C
Vigneron
Suzanne
S
Labbé
Jean-Claude
JC
Lorca
Thierry
T
D000705:Anaphase / Q000502:physiology*; D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division; D004261:DNA Replication; D006706:Homeostasis; D008938:Mitosis / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism; D044763:Ubiquitin-Conjugating Enzymes / Q000502:physiology*; D043743:Ubiquitin-Protein Ligase Complexes / Q000502:physiology*
D025801:Ubiquitin; D044763:Ubiquitin-Conjugating Enzymes; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome