Oxytocin during myomectomy: a randomized study.
OBJECTIVE
To evaluate the influence of oxytocin on peroperative blood loss during myomectomy.


METHODS
From October 1998 to May 2002, 94 patients requiring surgical myomectomy by laparotomy or by the vaginal approach were enrolled in a randomized double blind study. Patients were randomized to two groups. In the first group (47 patients) oxytocin was administered during myomectomy and in the second group (47 patients) a placebo was used. The main outcome measures were peroperative blood loss and rates of blood transfusion and autotransfusion.


RESULTS
Peroperative blood loss was no different between the oxytocin group and the placebo group (508 +/- 558 ml versus 451 +/- 336 ml; P=0.55). Rates of autotransfusion and blood transfusion were also similar in both groups.


CONCLUSIONS
Administration of oxytocin during myomectomy did not reduce peroperative blood loss in our study. The benefits of using oxytocin to prevent hemorrhage during myomectomy seem to be limited.
Agostini
Aubert
A
Service de Gynécologie, Hôpital La Conception, 147 Boulevard Baille, 13385 Marseille, France. aagostini@mail.ap-hm.fr
Ronda
Isabelle
I
Franchi
Fabrice
F
Bretelle
Florence
F
Roger
Valérie
V
Cravello
Ludovic
L
Blanc
Bernard
B
D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion; D004311:Double-Blind Method; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007889:Leiomyoma / Q000601:surgery*; D008875:Middle Aged; D010121:Oxytocin / Q000008:administration & dosage*; D010919:Placebos; D014594:Uterine Neoplasms / Q000601:surgery*
D006454:Hemoglobins; D010919:Placebos; D010121:Oxytocin