Colonization of gnotobiotic piglets by a luxS mutant strain of Escherichia coli O157:H7.
Gnotobiotic piglets inoculated with Escherichia coli O157:H7, its luxS mutant derivative, or nonpathogenic E. coli were evaluated for attaching and effacing lesions. Although no differences in clinical symptoms were seen between pigs inoculated with the parent and those inoculated with the luxS mutant, the luxS mutant-inoculated pigs had a lower frequency of attaching and effacing lesions in the spiral colon than parent strain-inoculated pigs.
Jordan
Dianna M
DM
Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA 50011, USA. dmjordan@iastate.edu
Sperandio
Vanessa
V
Kaper
James B
JB
Dean-Nystrom
Evelyn A
EA
Moon
Harley W
HW
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D013437:Carbon-Sulfur Lyases; D002448:Cell Adhesion / Q000235:genetics / Q000502:physiology; D003106:Colon / Q000382:microbiology; D004927:Escherichia coli Infections / Q000378:metabolism*; D019453:Escherichia coli O157 / Q000235:genetics* / Q000378:metabolism; D005856:Germ-Free Life; D009154:Mutation; D013552:Swine / Q000382:microbiology*
D001426:Bacterial Proteins; D013437:Carbon-Sulfur Lyases; C117753:LuxS protein, Bacteria