title: Endoplasmic reticulum-associated degradation: exceptions to the rule.
abstract: Quality control mechanisms in the endoplasmic reticulum (ER) ensure that misfolded proteins are recognized and targeted for degradation. According to the current view of ER-associated degradation (ERAD), the degradation does not occur in the ER itself but requires the retrotranslocation of the proteins to the cytosol where they are degraded by proteasomes. Although this model appears to be valid for many different proteins a number of exceptions from this rule suggest that additional proteasome-independent ERAD pathways may exist. In this review, we will summarize what is known about these alternative ERAD pathways.
authors.affiliation: Institut für Zellbiologie, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany. anton.schmitz@uni-bonn.de
authors.forename: Anton
authors.initials: A
authors.lastname: Schmitz
authors.forename: Volker
authors.initials: V
authors.lastname: Herzog
mesh_terms: D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D008954:Models, Biological; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins; D046988:Proteasome Endopeptidase Complex