Mast cells and autoimmunity.
Mast cells (MCs) are major effector cells in allergic diseases. Recently, it has become evident that the contribution of MCs extends far beyond their accepted role in allergic disease, and that they play a more extensive role in a variety of non-allergic immune processes such as the innate immunity response. These cells have a key role in both the induction and elicitation of several autoimmune conditions. Targeting MC development, maturation or activation may be of value in future prevention and treatment of autoimmune conditions.
Rottem
Menachem
M
Division of Allergy and Clinical Immunology, Ha'Emek Medical Center, Afula 18101, Israel. menachem@rotten.net
Mekori
Yoseph A
YA
D015551:Autoimmunity / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008407:Mast Cells / Q000276:immunology*
D007073:Immunoglobulin E