Preventive and therapeutic effect of complex antioxidant preparation in rats with burn trauma.
The production of blood radicals and activity of superoxide dismutase in erythrocytes increased in rats with contact burn trauma (20%). In animals with burn trauma antioxidant activity of the plasma was much lower, while myeloperoxidase content in the lung tissue and epidermis was higher than in control rats. The complex of antioxidants (Immudzhen) inhibited radical generation at the peak of inflammation (day 4), increased antioxidant activity of the plasma, and normalized myeloperoxidase content in the lung tissue.
Mikhal'chik
E V
EV
Department of Molecular Biology, Russian State Medical University, Moscow, Russia. lemik@zmail.ru
Ivanova
A V
AV
Anurov
M V
MV
Titkova
S M
SM
Pen'kov
L Yu
LY
Korkina
L G
LG
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002056:Burns / Q000628:therapy*; D004798:Enzymes / Q000097:blood; D005609:Free Radicals / Q000378:metabolism; D007249:Inflammation / Q000517:prevention & control*; D008168:Lung / Q000201:enzymology; D009195:Peroxidase / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D004798:Enzymes; D005609:Free Radicals; D009195:Peroxidase