[Relationship between aneuploidy of chromosome 17 and amplification of HER-2/neu gene in the different histological type of breast cancer].
We examined the relationship between the aneuploidy of chromosome 17 and the amplification of HER-2/neu gene by fluorescence in situ hybridization (FISH) in the different histological type of breast cancer (n = 55). 51 patients recognized the aneuploidy that consisted of 37 patients of monosomy and 14 patients of polysomy. In the scirrhous carcinoma, HER-2/neu gene was amplified in 15% of monosomy cases, but it was not amplified in all polysomy cases. In the papillotubular carcinoma, HER-2/neu gene was contrastively amplified in all polysomy cases, but it was not amplified in all monosomy cases. No case of solid-tubular carcinoma recognized the amplification. The relation was different according to the histological type of breast cancer.
Kuroso
Kazuko
K
Department of Pathology, Dokkyo University School of Medicine, Koshigaya Hospital, Koshigaya 343-8555.
Ueda
Yoshihiko
Y
Mori
Yoshiomi
Y
D000230:Adenocarcinoma / Q000235:genetics; D002293:Adenocarcinoma, Scirrhous / Q000235:genetics; D000782:Aneuploidy; D001943:Breast Neoplasms / Q000235:genetics*; D002291:Carcinoma, Papillary / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005784:Gene Amplification; D018734:Genes, erbB-2 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence