[The fight against doping: today and tomorrow].
Since Antiquity, sport persons have used doping methods to improve their performance. The methods used today are increasingly specific and professional As a corrolary, doping is becoming extremely difficult to detect: because many prohibited drugs are rapidly metabolized (short half life); it is often impossible to distinguish between the natural and recombinant hormone products; several prohibited substances are not screened for; therapeutic use authorization (TUA)--a recent recommendation from the World antidoping agency (WADA)--and advances in gene therapy are giving cheaters new possibilities. It is necessary to promote a new approach to doping detection by determining potential specific links between changes in human biological profiles (proteom, transcriptom, metabonom), and the use of a given drug. Developments in nanotechnology, and notably" labs on a chip" should prove useful in this respect.
Rieu
Michel
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Conseil de prévention et de lutte contre le dopage, 39 rue Saint Dominique, 75007 Paris.
D004300:Doping in Sports / Q000517:prevention & control*; D018390:Gene Targeting; D015316:Genetic Therapy; D006801:Humans; D010807:Physical Endurance / Q000235:genetics; D011619:Psychotropic Drugs / Q000494:pharmacology; D015813:Substance Abuse Detection / Q000379:methods
D011619:Psychotropic Drugs