Branch retinal artery occlusions as the presenting feature of primary central nervous system vasculitis.
A 39-year-old woman presented with multiple branch retinal artery occlusions almost three years before developing a mass lesion containing calcium in the left frontal lobe. Brain biopsy revealed a small vessel vasculitis and ischemic necrosis of brain with dystrophic calcification. We believe this to be the first case of primary CNS vasculitis with branch retinal artery occlusions and brain calcification.
Susac
J O
JO
Neurology & Neurosurgery Associates, Winter Haven, Florida 33880, USA. jsusac@neurohaven.com
Calabrese
L H
LH
Baylin
E
E
Prayson
R A
RA
Medeiros
N E
NE
Hull
R P
RP
Tucker
J P
JP
D000328:Adult; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D015356:Retinal Artery Occlusion / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D020293:Vasculitis, Central Nervous System / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D009173:Mycophenolic Acid; D011241:Prednisone