Adverse reactions to human rabies immune globulin manufactured by the Thai Red Cross Society.
Rabies Immunoglobulins (RIG) are an essential part of optimal management of rabies exposures [World Health Organization (WHO)]. They provide protection against the virus during the critical initial 7 days before adequate endogenous vaccine induced antibodies are formed. Even though Human Rabies Immune Globulin (HRIG) is the ideal product for post-exposure rabies treatment it, like most biological, can cause very rare adverse reactions. A retrospective review of a series of 8737 patients, who received HRIG at one institution, revealed that only 15 (0.183 %) reported transient mild adverse reactions.
Suwansrinon
Kanitta
K
Queen Saovabha Memorial Institute, Thai Red Cross Society (WHO Collaborating Center for Research in Rabies) and Department of Medicine, Chulalongkorn University, 1871 Rama IV Road, 10330 Bangkok, Thailand. sukanitta@yahoo.com
Jaijaroensup
Wipaporn
W
Daviratanasilpa
Svastijaya
S
Sriaroon
Chakrapol
C
Wilde
Henry
H
Sitprija
Visith
V
D000293:Adolescent; D005260:Female; D006801:Humans; D006967:Hypersensitivity; D007136:Immunoglobulins / Q000009:adverse effects* / Q000627:therapeutic use*; D011818:Rabies / Q000517:prevention & control*; D012189:Retrospective Studies; D013785:Thailand
D007136:Immunoglobulins