beta-Catenin: a pivot between cell adhesion and Wnt signalling.
Mutual adhesion of animal cells is intimately linked to Wnt signaling through a shared component: beta-catenin, or Armadillo in Drosophila. Recent work indicates how beta-catenin shifts from cell adhesion to Wnt signaling, a switch associated with epithelial-mesenchymal transitions and cancer.
Bienz
Mariann
M
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH UK. mb2@mrc-lmb.cam.ac.uk
D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000378:metabolism / Q000502:physiology*; D004847:Epithelial Cells / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism / Q000502:physiology*; D008648:Mesoderm / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism / Q000502:physiology*; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D051178:alpha Catenin; D051176:beta Catenin
D015820:Cadherins; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D036341:Intercellular Signaling Peptides and Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D051178:alpha Catenin; C492660:bcl9l protein, zebrafish; D051176:beta Catenin