title: Antifungal sesquiterpene from the root of Vernonanthura tweedieana.
abstract: The bioassay-guided fractionation of the antifungal dichloromethane extract from the roots of Vernonanthura tweedieana (Baker) H. Rob. (Asteraceae), using an agar overlay bioautographic method, allowed the isolation of one active sesquiterpene (1), identified as 6-cinnamoyloxy-1-hydroxyeudesm-4-en-3-one. Minimal inhibitory concentrations (MIC) and minimal fungicidal concentrations (MFC) of 1 showed Trichophyton mentagrophytes as the most sensitive strain, with the same MIC and MFC values (4 microg/ml).
authors.affiliation: Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain.
authors.forename: Aida
authors.initials: A
authors.lastname: Portillo
authors.forename: Roser
authors.initials: R
authors.lastname: Vila
authors.forename: Blanca
authors.initials: B
authors.lastname: Freixa
authors.forename: Esteban
authors.initials: E
authors.lastname: Ferro
authors.forename: Teodor
authors.initials: T
authors.lastname: Parella
authors.forename: Joseph
authors.initials: J
authors.lastname: Casanova
authors.forename: Salvador
authors.initials: S
authors.lastname: Cañigueral
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035741:Vernonia
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D012717:Sesquiterpenes