title: Platination of nucleobases to enhance noncovalent recognition in protein-DNA/RNA complexes.
abstract: Fluorescence quenching experiments show that the stacking interaction between nucleic acid bases and l-tryptophan is enhanced significantly upon base coordination to a metal center such as Pt(II), and the biological implications of such enhancement are discussed.
authors.affiliation: Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284-2006, USA.
authors.forename: Atilio I
authors.initials: AI
authors.lastname: Anzellotti
authors.forename: Erin S
authors.initials: ES
authors.lastname: Ma
authors.forename: Nicholas
authors.initials: N
authors.lastname: Farrell
mesh_terms: D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014364:Tryptophan / Q000737:chemistry*
chemical_list: D009944:Organoplatinum Compounds; D011506:Proteins; D010984:Platinum; D012313:RNA; D014364:Tryptophan; D004247:DNA