title: New trends in HDF therapies: validity of internal filtration-enhanced hemodialysis.
abstract: Internal filtration-enhanced hemodialysis (IFEHD), defined as HD therapy using a dialyzer designed for enhanced internal filtration, seems to be more convenient in comparison with HDF therapies. In this paper, the validity of IFEHD was discussed during an analytical study and experimental studies. As a result, the maximum internal filtration flow rate (Q(IF)) value increased with a smaller inner diameter (D), a longer effective length (L(eff)), and a larger density ratio (DR) value of the hollow fibers. The validity of IFEHD was clarified by an analytical study and experimental studies. Development of a dialyzer with enhanced internal filtration, however, should take account of the patient's safety, and hemolysis and endotoxin invasion form the dialysate to the patient should be avoided.
authors.affiliation: Clinical Engineering, Tokyo Women's Medical University, Tokyo, Japan. mmine@ce.twmu.ac.jp
authors.forename: Michio
authors.initials: M
authors.lastname: Mineshima
mesh_terms: D004867:Equipment Design; D017583:Hemodiafiltration / Q000639:trends*; D006440:Hemofiltration / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007700:Kinetics; D008962:Models, Theoretical; D009211:Myoglobin / Q000032:analysis; D006435:Renal Dialysis / Q000379:methods*; D018608:Ultrasonography, Doppler
chemical_list: D009211:Myoglobin