Deteriorative effect of smoking on target lesion revascularization after implantation of coronary stents with diameter of 3.0 mm or less.
BACKGROUND
Although smoking cessation is widely encouraged because of the associated risk of cardiovascular events, the impact of smoking on target lesion revascularization (TLR) after percutaneous coronary intervention (PCI) is controversial. Therefore, the present study retrospectively investigated the effect of smoking on TLR after plain-old balloon angioplasty (POBA; n=376) and stenting (STENT; n=434) in patients undergoing secondary coronary angiography at a single center.


RESULTS
A smoker was defined as current smoking or quitting within 2 years of the first PCI. In the POBA group, the predictors for TLR, as calculated by multiple logistic regression analysis, were a complex type of lesion (p<0.0001) and the left anterior descending artery (LAD) as affected vessel (p<0.05). In the STENT group, the predictors were the final % diameter of stenosis after stenting, measured by quantitative coronary arteriography (p<0.0005), LAD (p<0.01), and smoking (p=0.049). When the STENT group was divided into 2 groups according to the diameter of the implanted stent, smoking was a predictive factors for TLR in the group that received relatively small stents (diameter < or =3.0 mm) (p<0.02), but not in the group that received larger stents (diameter > or =3.5 mm).


CONCLUSIONS
Smoking has a deteriorative effect on TLR after implantation of relatively small coronary stents with a diameter of 3.0 mm or less.
Ishikawa
Tetsuya
T
Division of Cardiology, Saitama Cardiovascular and Respiratory Center, Kohnan, Japan. ishikawa@jikei.ac.jp
Yagi
Hidenori
H
Ogawa
Takashi
T
Mori
Chikara
C
Takeda
Hiroshi
H
Sakamoto
Hiroshi
H
Mutoh
Makoto
M
Seo
Atsushi
A
Shibata
Takahiro
T
Yoshida
Satoru
S
Imai
Kamon
K
Horie
Toshinobu
T
Mochizuki
Seibu
S
D015906:Angioplasty, Balloon, Coronary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000628:therapy; D009204:Myocardial Revascularization; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects*; D015607:Stents