Dynamic modeling of complex biological systems: a link between metabolic and macroscopic description.
In this study, a class of dynamic models based on metabolic reaction pathways is analyzed, showing that systems with complex intracellular reaction networks can be represented by macroscopic reactions relating extracellular components only. Based on rigorous assumptions, the model reduction procedure is systematic and allows an equivalent 'input-output' representation of the system to be derived. The procedure is illustrated with a few examples.
Haag
Jens E
JE
Service d'Automatique, Faculté Polytechnique de Mons, 31 Boulevard Dolez, 7000 Mons, Belgium.
Vande Wouwer
Alain
A
Bogaerts
Philippe
P
D000465:Algorithms; D000818:Animals; D018533:Biomass; D019149:Bioreactors; D001709:Biotechnology / Q000379:methods; D049109:Cell Proliferation; D002478:Cells, Cultured; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D006825:Hybridomas / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D017711:Nonlinear Dynamics