[NiFe]-Hydrogenase maturation endopeptidase: structure and function.
Hydrogenase maturation endopeptidases catalyse the terminal step in the maturation of the large subunit of [NiFe]-hydrogenases. They remove a C-terminal extension from the precursor of the subunit, triggering a conformational switch that results in the bridging of the Fe and Ni atoms of the metal centre via the thiolate of a cysteine residue and in closure of the centre. This review summarizes what is known about the structure of the protein, its substrate specificity and its possible reaction mechanism.
Theodoratou
E
E
Department Biologie I, University of Munich, Maria-Ward-Strasse 1a, D-80638 Munich, Germany.
Huber
R
R
Böck
A
A
D006864:Hydrogenase / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
C043296:nickel-iron hydrogenase; D006864:Hydrogenase