CSF-chemokines in HTLV-I-associated myelopathy: CXCL10 up-regulation and therapeutic effect of interferon-alpha.
We measured four chemokines in the cerebrospinal fluid (CSF) in human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with ELISA. CXCL10/IP-10, a T cell type 1 (Th1)-associated chemokine, was significantly elevated in HAM/TSP compared with controls, and the values were even significantly higher in HAM/TSP than in multiple sclerosis (MS) in which CXCL10/IP-10 up-regulation was previously reported. Among Th2-associated chemokines, CCL17/TARC and CCL11/Eotaxin in HAM/TSP were not different from those in controls. As shown in MS, CCL2/MCP-1 was significantly lower in HAM/TSP than in control. Following interferon (IFN)-alpha therapy in HAM/TSP, CCL2/MCP-1 became significantly higher than that before therapy, which may reflect a Th2 induction, while CXCL10/IP-10 remained elevated.
Narikawa
Koichi
K
Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aobaku, Sendai 980-8574, Japan.
Fujihara
Kazuo
K
Misu
Tatsuro
T
Feng
Juan
J
Fujimori
Juichi
J
Nakashima
Ichiro
I
Miyazawa
Isabelle
I
Saito
Hiroshi
H
Sato
Shigeru
S
Itoyama
Yasuto
Y
D000328:Adult; D000368:Aged; D054413:Chemokine CCL11; D054414:Chemokine CCL17; D018932:Chemokine CCL2 / Q000096:biosynthesis / Q000097:blood / Q000134:cerebrospinal fluid; D054357:Chemokine CXCL10; D019742:Chemokines, CC / Q000097:blood / Q000134:cerebrospinal fluid; D019743:Chemokines, CXC / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology / Q000628:therapy; D015493:Paraparesis, Tropical Spastic / Q000134:cerebrospinal fluid* / Q000276:immunology* / Q000628:therapy; D011933:Reagent Kits, Diagnostic; D015854:Up-Regulation / Q000276:immunology*
C515456:CCL11 protein, human; C106230:CCL17 protein, human; D054413:Chemokine CCL11; D054414:Chemokine CCL17; D018932:Chemokine CCL2; D054357:Chemokine CXCL10; D019742:Chemokines, CC; D019743:Chemokines, CXC; D016898:Interferon-alpha; D011933:Reagent Kits, Diagnostic