Pancreatic involvement in Von Hippel-Lindau disease.
BACKGROUND
Involvement of the pancreas in Von Hippel-Lindau disease that is a tumor predisposing syndrome mentioned in literature with some morbid and mortal progression.


OBJECTIVE
For evaluation the faith of the pancreatic involvement in VHL disease we analysed our patient population with VHL disease.


METHODS
12 of the 56 patients that were evaluated in our institute with the diagnosis of Von Hippel-Lindau disease had pancreatic involvement. They are periodically examined for 5 years follow up period. Their retrospective analysis was accomplished.


CONCLUSIONS
Pancreatic involvement in our patient population disclosed lesions that were multicysts or serous cystadenomas. During follow up period, we did not observe significant morbidity related to pancreatic involvement. Repeated radiological examination of pancreatic lesions disclosed insignificant modifications such as slight increase or decrease in size. Whereas we considered morbidity and mortality related to renal and central nervous system pathologies in VHL disease. Shortly, even pancreatic involvement in VHL disease requires close clinical follow up, morbidity and mortality in this case is not severe as in renal and the central nervous system involvement.
Eras
Mustafa
M
Clinics of Neurosurgery, Educational Hospital in Istanbul, Turkey.
Yenigun
Mustafa
M
Acar
Cengiz
C
Kumbasar
Baki
B
Sar
Fuat
F
Bilge
Turgay
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000209:etiology / Q000473:pathology; D018293:Cystadenoma, Serous / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010181:Pancreatic Cyst / Q000209:etiology / Q000473:pathology; D010182:Pancreatic Diseases / Q000209:etiology* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000209:etiology / Q000473:pathology; D012189:Retrospective Studies; D006623:von Hippel-Lindau Disease / Q000150:complications*