Age-dependent changes in susceptibility of suckling mice to individual strains of Helicobacter pylori.
To model establishment of Helicobacter pylori infection in infants, suckling mice were inoculated with mixtures of strains that preferentially colonize different gastric regions and coexist in vivo. Characterization of H. pylori recovered 2 weeks later showed that susceptibility begins earlier for some strains than for others and that the onset of susceptibility varies among mouse lines.
Suto
Hiroyuki
H
Department of Molecular Microbiology, Campus Box 8230, Washington University Medical School, 4940 Parkview Pl., St. Louis, MO 63110, USA.
Zhang
Maojun
M
Berg
Douglas E
DE
D000367:Age Factors; D000818:Animals; D005260:Female; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology* / Q000472:pathogenicity; D007109:Immunity / Q000276:immunology*; D008297:Male; D051379:Mice; D013270:Stomach / Q000382:microbiology*