title: Successful treatment of surgically induced necrotizing scleritis with tacrolimus.
abstract: A 46-year-old man developed surgically induced necrotizing scleritis (SINS) 7 months following uneventful primary bare sclera pterygium excision. The patient underwent two scleral patch grafts for SINS but despite the use of cyclophosphamide and azathioprine, the scleral patch grafts failed within 1 month of surgery on both occasions. Tacrolimus was used for his third scleral patch graft. No recurrence of necrotizing scleritis was observed for 2 years. Tacrolimus may be considered as a valuable adjunctive immunosuppressant in the management of resistant necrotizing scleritis.
authors.forename: Alvin L
authors.initials: AL
authors.lastname: Young
authors.forename: S M
authors.initials: SM
authors.lastname: Wong
authors.forename: Alfred T S
authors.initials: AT
authors.lastname: Leung
authors.forename: Gloria Y S
authors.initials: GY
authors.lastname: Leung
authors.forename: Lulu L
authors.initials: LL
authors.lastname: Cheng
authors.forename: Dennis S C
authors.initials: DS
authors.lastname: Lam
mesh_terms: D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000009:adverse effects*; D011625:Pterygium / Q000601:surgery; D012008:Recurrence; D012086:Reoperation; D012590:Sclera / Q000637:transplantation*; D015423:Scleritis / Q000188:drug therapy* / Q000209:etiology; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus