Plasminogen activator inhibitor 1 activity and other coronary risk factors.
Because only some coronary risk factors have been evaluated for an association with plasma plasminogen activator inhibitor 1 (PAI-1) activity, this cross-sectional study examined the association between 27 coronary risk factors and PAI-1 in 24 healthy persons without coronary heart disease (control persons) and 22 patients who had survived myocardial infarction (cases). The coronary risk factors included major coronary risk factors such as age, anthropometric measures such as intraabdominal fat, and biochemical analytes such as serum concentration of triglyceride and plasma von Willebrand factor activity. The associations were analyzed in univariate and multiple linear regression analyses. For the control persons, triglyceride and von Willebrand factor were significantly associated with PAI-1 activity (p=0.0002, R(2)=0.55). In contrast for the 24 cases, age and intraabdominal adipose tissue were significantly associated with PAI-1 (p=0.0011, R(2)=0.51). Coronary risk factors explained more than half the variation of PAI-1 activity for both study groups. However, healthy persons and patients with previous myocardial infarction differed regarding coronary risk factors associated with PAI-1.
von Eyben
Finn Edler
FE
Department of Internal Medicine, Herning Central Hospital, Denmark. finnvon@mail.tele.dk
Mouritsen
Ejvind
E
Holm
Jan
J
Montvilas
Paulius
P
Dimcevski
Georg
G
Suciu
Gabriel
G
Rasmussen
Inger Helleberg
IH
Kristensen
Lisbeth Langholz
LL
von Eyben
Rie
R
D000273:Adipose Tissue; D000328:Adult; D000375:Aging; D003327:Coronary Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012044:Regression Analysis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis
D017395:Plasminogen Activator Inhibitor 1; D014280:Triglycerides; D014841:von Willebrand Factor