title: A new therapeutic challenge for old pathogens: community-acquired invasive infections caused by ceftriaxone- and ciprofloxacin-resistant Salmonella enterica serotype choleraesuis.
abstract: Recently, antimicrobial resistance among nontyphoid Salmonella serotypes has been increasingly recognized. In southern Taiwan, we encountered 3 cases of invasive infections caused by Salmonella enterica serotype Choleraesuis with resistance to ciprofloxacin and ceftriaxone. Resistance to ciprofloxacin was related to nucleotide mutations in gyrA and parC, and resistance to ceftriaxone was related to the presence of CMY-2 beta -lactamase.
authors.affiliation: Department of Medicine, National Cheng Kung University Medical College, Taiwan.
authors.forename: Wen-Chien
authors.initials: WC
authors.lastname: Ko
authors.forename: Jing-Joung
authors.initials: JJ
authors.lastname: Yan
authors.forename: Wen-Liang
authors.initials: WL
authors.lastname: Yu
authors.forename: Hsin-Chun
authors.initials: HC
authors.lastname: Lee
authors.forename: Nan-Yao
authors.initials: NY
authors.lastname: Lee
authors.forename: Li-Rong
authors.initials: LR
authors.lastname: Wang
authors.forename: Yin-Ching
authors.initials: YC
authors.lastname: Chuang
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D002443:Ceftriaxone / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology*; D027081:DNA Gyrase; D027101:DNA Topoisomerase IV; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012475:Salmonella / Q000187:drug effects* / Q000235:genetics; D012480:Salmonella Infections / Q000188:drug therapy / Q000382:microbiology*; D013624:Taiwan / Q000453:epidemiology; D001618:beta-Lactamases
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D002443:Ceftriaxone; C103022:beta-lactamase CMY-2; D001618:beta-Lactamases; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase