title: [Usefulness of the FRFSE method in SPIO-MRI].
abstract: OBJECTIVE
  Super-paramagnetic iron oxide-enhanced magnetic resonance imaging (SPIO-MRI) is highly sensitive for liver tumors. This trial examined the optimal parameters of the fast recovery fast spin echo (FRFSE) method in SPIO-MRI. The FRFSE method is a pulse sequence with recovery of the compulsory longitudinal magnetization. The FRFSE method used in SPIO-MRI has better sensitivity for liver tumor, better tumor contrast, and can be used with respiratory gating.
  
  
  METHODS
  The phantoms used included a ferucarbotran phantom, water phantom, and gelatin phantom. Each phantom was scanned by the FRFSE method and fast spin echo (FSE) method, with changing of scanning parameters, and each CNR was measured. Each CNR was given a point, and points were averaged according to each parameter. Parameters that obtained high average points were considered optimal parameters.
  
  
  RESULTS
  The optimal parameters were set to TE=50 ms in the FRFSE method. The scan parameters optimized from the phantom study were used in a clinical case, and good results were achieved, as in the phantom study.
  
  
  CONCLUSIONS
  We optimized the scan parameters of the FRFSE method and were able to suggest the usefulness of the FRFSE method in SPIO-MRI.
authors.affiliation: Kitasato University, School of Allied Health Sciences.
authors.forename: Masanori
authors.initials: M
authors.lastname: Ozaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Hata
authors.forename: Katsumi
authors.initials: K
authors.lastname: Kubota
authors.forename: Kenji
authors.initials: K
authors.lastname: Mine
authors.forename: Hironori
authors.initials: H
authors.lastname: Hanawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Aizawa
authors.forename: Naoji
authors.initials: N
authors.lastname: Suzuki
mesh_terms: D003287:Contrast Media; D007501:Iron; D008113:Liver Neoplasms / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010087:Oxides
chemical_list: D003287:Contrast Media; D010087:Oxides; D007501:Iron