title: Cortical thickness of the frontopolar area in typically developing children and adolescents.
abstract: The development of the frontopolar cortex (FPC) through late childhood and adolescence was investigated using measures of cortical thickness. T(1)-weighted structural MRIs from 35 typically developing participants aged 8-20 years were used to construct 3D models of the brain, from which cortical thickness was measured. There was a significant inverse association between age and cortical thickness, such that cortical thickness decreased as age increased between 8 and 20 years. There was no effect of laterality or gender on cortical thickness.
authors.affiliation: Brain and Behaviour Program, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
authors.forename: Shannon
authors.initials: S
authors.lastname: O'Donnell
authors.forename: Michael D
authors.initials: MD
authors.lastname: Noseworthy
authors.forename: Brian
authors.initials: B
authors.lastname: Levine
authors.forename: Maureen
authors.initials: M
authors.lastname: Dennis
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000254:growth & development*; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000254:growth & development*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012727:Sex Characteristics; D014793:Visual Cortex / Q000033:anatomy & histology / Q000254:growth & development