[The multidrug tumor cell resistance phenotype caused by the impaired cell death program].
The paper shows the role of tumor cell apoptosis induction in the mechanism of cancer cytoreductive therapy and the significance of the impaired cell death program for the pathogenesis of the phenotype of multidrug and radiation resistance resulted from the use of specific antitumor therapy and from the natural course of tumor progression.
Blokhin
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D018943:Anthracyclines / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis; D018450:Disease Progression; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D016158:Genes, p53; D006801:Humans; D008942:Mitoxantrone / Q000494:pharmacology / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000532:radiotherapy; D010641:Phenotype; D011034:Podophyllotoxin / Q000494:pharmacology / Q000627:therapeutic use; D011836:Radiation Tolerance; D014407:Tumor Cells, Cultured
D018943:Anthracyclines; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D008942:Mitoxantrone; D011034:Podophyllotoxin