A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission.
A crude CH(2)Cl(2)-MeOH extract prepared from Commiphora africana was found to mediate Cu(2+)-dependent relaxation of supercoiled plasmid DNA. Bioassay-guided fractionation of this extract was carried out and was monitored by the use of an in vitro DNA strand scission assay. The dihydroflavonol glucoside phellamurin (1) was identified as the active principle responsible for the DNA cleavage activity of the crude extract.
Ma
Ji
J
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22901, USA.
Jones
Shannon H
SH
Hecht
Sidney M
SM
D029744:Commiphora / Q000737:chemistry*; D003300:Copper / Q000494:pharmacology; D004247:DNA / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013636:Tanzania
D005419:Flavonoids; D005960:Glucosides; C016043:phellamurin; D003300:Copper; D004247:DNA