title: Chemical-shift-selective filter for the in vivo detection of J-coupled metabolites at 3T.
abstract: A chemical-shift-selective filter (CSSF) was applied to the detection of J-coupled metabolites in the human brain. This filter is an acquisition-based technique that requires the chemical shifts (CS's) of different metabolites, but not their whole multiplet structures, to be resolved. The sequence is based on the 2D constant-time spin-echo experiment, which yields pure CS spectra in the indirect dimension. Localization is achieved through point-resolved spectroscopy (PRESS). The method enables unequivocal detection of glutamate and myo-inositol, both in vitro and in vivo in the human brain, at 3T.
authors.affiliation: Institute for Biomedical Engineering, University of Zurich and Swiss Federal Institute of Technology, Zurich, Switzerland.
authors.forename: Rolf F
authors.initials: RF
authors.lastname: Schulte
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Trabesinger
authors.forename: Peter
authors.initials: P
authors.lastname: Boesiger
mesh_terms: D000328:Adult; D000465:Algorithms; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000378:metabolism*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D014018:Tissue Distribution
chemical_list: D018377:Neurotransmitter Agents