Selective attachment and release of a chemotherapeutic agent from the interior of a protein cage architecture.
The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.
Flenniken
Michelle L
ML
Department of Microbiology, Montana State University, Lewis Hall, Bozeman, MT, USA.
Liepold
Lars O
LO
Crowley
Bridgid E
BE
Willits
Deborah A
DA
Young
Mark J
MJ
Douglas
Trevor
T
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D004591:Electrophoresis, Polyacrylamide Gel; D006360:Heat-Shock Proteins / Q000737:chemistry* / Q000235:genetics; D017017:Methanococcus / Q000737:chemistry; D015202:Protein Engineering; D021122:Protein Subunits / Q000737:chemistry / Q000235:genetics
D000903:Antibiotics, Antineoplastic; D006360:Heat-Shock Proteins; D021122:Protein Subunits; D004317:Doxorubicin