title: Cytosporone E: racemic synthesis and preliminary antibacterial testing.
abstract: The antibiotic cytosporone E (isolated from the broth of the endophytic fungi CR 200 (Cytospora sp.) and CR 146 (Diaporthe sp.)) was synthesized as a racemic mixture. The key step in the synthesis is the Meyers ortho-alkylation of a chiral aromatic oxazoline. Preliminary antibiotic activity shows antibiosis against Gram-positive bacteria but not Gram-negative bacteria as previously reported.
authors.affiliation: Department of Chemistry and Biochemistry, College of Charleston, 66 George Street, Charleston, SC 29424, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Hall
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Duncan-Gould
authors.forename: Nasar A
authors.initials: NA
authors.lastname: Siddiqi
authors.forename: Jennifer N
authors.initials: JN
authors.lastname: Kelly
authors.forename: L Alexis
authors.initials: LA
authors.lastname: Hoeferlin
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Morrison
authors.forename: Justin K
authors.initials: JK
authors.lastname: Wyatt
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests
chemical_list: D001572:Benzofurans; C492581:cytosporone E