Comparative study of vasaprostan and alprostan in spontaneous platelet aggregation test in mice.
We propose a method for evaluation of spontaneous aggregation of mouse platelets based on routine clinical blood tests for humans. Comparative analysis of Vasaprostan and Alprostan drugs showed that this test can be used for testing of new drugs on animals.
Gol'dshtein
D V
DV
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.
Maevskii
E I
EI
Pogorelova
V N
VN
D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D000527:Alprostadil