title: Left ventricular mass indexed to height and prevalent MRI cerebrovascular disease in an African American cohort: the Atherosclerotic Risk in Communities study.
abstract: OBJECTIVE
  Previous studies have demonstrated that echocardiographic left ventricular mass (LVM) is an independent risk factor for stroke in whites. Despite the greater burden of stroke, the echocardiographic predictors of stroke in African Americans remain poorly understood.
  
  
  METHODS
  This investigation is a retrospective analysis of prospectively collected data from the Jackson, Miss (all African American), cohort of the Atherosclerotic Risk in the Communities study. Between 1993 and 1995, 2445 participants received an echocardiogram, and a random subset (n=778) received cerebral MRI evaluating presence of infarcts or white matter disease (WMD; >3 on a scale of 0 to 9). Compared with the entire Jackson cohort, the random subset was older, had a lower body mass index (BMI), and a higher systolic blood pressure (SBP). Logistic regression models examined the relations of LVM indexed by height (LVM/height) to MRI findings adjusted for age, gender, BMI, SBP, hypertensive medications, diabetes, total/high-density lipoprotein cholesterol, smoking status, and history of myocardial infarction.
  
  
  RESULTS
  The 667 participants (63% women; 62+/-4 years of age) had a high prevalence of hypertension (68%), obesity (46%), echocardiographic left ventricular hypertrophy (49%), MRI stroke (n=133), and WMD (n=92). Adjusted LVM/height was significantly associated with prevalent MRI stroke (odds ratio [OR], 1.3; 95% CI, 1.1 to 1.7; P=0.02) and WMD (OR, 1.5; 95% CI, 1.1 to 1.9; P=0.006; OR expressed per 1 SD LVM/height, 45 g/m).
  
  
  CONCLUSIONS
  In this randomized subset of a population-based cohort of African American adults, LVM/height was related to MRI evidence of prevalent cerebrovascular disease. The current study supports the hypothesis that LVM/height is an important risk factor for stroke in multiple ethnicities.
authors.affiliation: NHLBI Jackson Heart Study, Mississippi, USA. efox@medicine.umsmed.edu
authors.forename: Ervin R
authors.initials: ER
authors.lastname: Fox
authors.forename: Herman A
authors.initials: HA
authors.lastname: Taylor
authors.forename: Emelia J
authors.initials: EJ
authors.lastname: Benjamin
authors.forename: Jingzhong
authors.initials: J
authors.lastname: Ding
authors.forename: Philip R
authors.initials: PR
authors.lastname: Liebson
authors.forename: Donna
authors.initials: D
authors.lastname: Arnett
authors.forename: Ernest M
authors.initials: EM
authors.lastname: Quin
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Skelton
mesh_terms: D001741:Black or African American; D000368:Aged; D001161:Arteriosclerosis / Q000453:epidemiology*; D001827:Body Height / Q000502:physiology*; D002531:Cerebellum / Q000098:blood supply / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000473:pathology; D015331:Cohort Studies; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D011159:Population Surveillance; D011446:Prospective Studies; D012189:Retrospective Studies