title: Plasminogen activator inhibitor 1 activity and other coronary risk factors.
abstract: Because only some coronary risk factors have been evaluated for an association with plasma plasminogen activator inhibitor 1 (PAI-1) activity, this cross-sectional study examined the association between 27 coronary risk factors and PAI-1 in 24 healthy persons without coronary heart disease (control persons) and 22 patients who had survived myocardial infarction (cases). The coronary risk factors included major coronary risk factors such as age, anthropometric measures such as intraabdominal fat, and biochemical analytes such as serum concentration of triglyceride and plasma von Willebrand factor activity. The associations were analyzed in univariate and multiple linear regression analyses. For the control persons, triglyceride and von Willebrand factor were significantly associated with PAI-1 activity (p=0.0002, R(2)=0.55). In contrast for the 24 cases, age and intraabdominal adipose tissue were significantly associated with PAI-1 (p=0.0011, R(2)=0.51). Coronary risk factors explained more than half the variation of PAI-1 activity for both study groups. However, healthy persons and patients with previous myocardial infarction differed regarding coronary risk factors associated with PAI-1.
authors.affiliation: Department of Internal Medicine, Herning Central Hospital, Denmark. finnvon@mail.tele.dk
authors.forename: Finn Edler
authors.initials: FE
authors.lastname: von Eyben
authors.forename: Ejvind
authors.initials: E
authors.lastname: Mouritsen
authors.forename: Jan
authors.initials: J
authors.lastname: Holm
authors.forename: Paulius
authors.initials: P
authors.lastname: Montvilas
authors.forename: Georg
authors.initials: G
authors.lastname: Dimcevski
authors.forename: Gabriel
authors.initials: G
authors.lastname: Suciu
authors.forename: Inger Helleberg
authors.initials: IH
authors.lastname: Rasmussen
authors.forename: Lisbeth Langholz
authors.initials: LL
authors.lastname: Kristensen
authors.forename: Rie
authors.initials: R
authors.lastname: von Eyben
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D000375:Aging; D003327:Coronary Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012044:Regression Analysis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D014280:Triglycerides; D014841:von Willebrand Factor