FOXP2 polymorphisms in patients with schizophrenia.
BACKGROUND
FOXP2 was described as the first gene involved in our ability to acquire spoken language. The main objective of this study was to compare the distribution of FOXP2 gene polymorphisms between patients with schizophrenia and healthy controls.


METHODS
Two FOXP2 polymorphisms, Intron3a and SNP 923875, and the G-->A transition in exon 14 were analysed in 149 patients with schizophrenia and schizoaffective disorders according to DSM-IV, as well as in 137 controls. All the patients showed a history of auditory hallucinations.


RESULTS
The transition G-->A at exon 14, detected in all the affected members in KE family, was not found in any of the analyzed samples from patients or controls. No significant differences were found between individual controls and patients for the two analysed polymorphisms.


CONCLUSIONS
This study would not support a possible role of the two FOXP2 analyzed polymorphisms in the vulnerability to schizophrenia.
Sanjuan
Julio
J
Unidad de Psiquiatría, Facultad de Medicina, Hospital Clínico, Universitat de València, Blasco Ibaez 15, 46010 Valencia, Spain. julio.sanjuan@uv.es
Tolosa
Amparo
A
González
Jose Carlos
JC
Aguilar
Eduardo Jesus
EJ
Moltó
Maria Dolores
MD
Nájera
Carmen
C
de Frutos
Rosa
R
D000328:Adult; D000368:Aged; D000483:Alleles; D017931:DNA Primers / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005091:Exons / Q000235:genetics; D005260:Female; D051858:Forkhead Transcription Factors; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006212:Hallucinations / Q000453:epidemiology; D006801:Humans; D007438:Introns / Q000235:genetics; D007806:Language Disorders / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012189:Retrospective Studies; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D012720:Severity of Illness Index; D014157:Transcription Factors / Q000235:genetics*
D017931:DNA Primers; C465448:FOXP2 protein, human; D051858:Forkhead Transcription Factors; D014157:Transcription Factors