An analysis of data from two general health surveys found that increased incidence and duration contributed to elevated prevalence of major depression in persons with chronic medical conditions.
OBJECTIVE
The prevalence of major depression is increased in people with chronic medical conditions. The objective of this analysis was to determine whether this is due to a higher incidence, an impact on prognosis, or an effect of mortality.


METHODS
An analysis of data collected in two national Canadian general health surveys was carried out. Markov models representing period prevalence, incidence, mortality, and recovery were developed using these data sources. Monte Carlo simulation, using tracking variables, was used to evaluate the model.


RESULTS
The incidence of major depression was higher in subjects with chronic medical conditions. However, the pattern of recovery was also different: Subjects with chronic medical conditions had slightly longer episode durations. The analysis of mortality data was limited by a small number of deaths in the survey sample; however, the models suggested that the impact of mortality on the association is small.


CONCLUSIONS
An elevated prevalence of major depression has been observed in persons with chronic medical conditions. Two factors seem to contribute to this association: increased episode incidence and duration.
Patten
Scott B
SB
Department of Community Health Sciences, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada. patten@ucalgary.ca
D002170:Canada / Q000453:epidemiology; D002908:Chronic Disease; D003627:Data Interpretation, Statistical; D003863:Depression / Q000150:complications / Q000453:epidemiology*; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D009026:Mortality; D015995:Prevalence; D016896:Treatment Outcome