title: A family-based association study of the MOG gene with schizophrenia in the Chinese population.
abstract: Recently the expression of human myelin/oligodendrocyte glycoprotein (MOG) has been found to be significantly downregulated in the brain tissue of subjects with schizophrenia, suggesting that the MOG gene resides within a high-susceptibility locus for schizophrenia. In order to test this prediction, we analyzed three microsatellites from MOG in the Han Chinese population using a sample of 532 trios. Analysis of allele, genotype and haplotype frequencies showed weak positive association between the markers and the disease (p=0.01982). Our results would indicate that the MOG gene may play a significant role in schizophrenia in the Han Chinese. However, further study is required using other methods and involving other populations.
authors.affiliation: Bio-X Life Science Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, P.R. China.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.forename: Guang
authors.initials: G
authors.lastname: He
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Yang
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Dawei
authors.initials: D
authors.lastname: Li
authors.forename: Niufan
authors.initials: N
authors.lastname: Gu
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Xu
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Hong
authors.initials: H
authors.lastname: Sang
authors.forename: Xinming
authors.initials: X
authors.lastname: Hao
authors.forename: Kui
authors.initials: K
authors.lastname: Zhang
authors.forename: Shiji
authors.initials: S
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D002874:Chromosome Mapping; D017931:DNA Primers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats / Q000235:genetics; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000235:genetics*; D063308:Myelin-Oligodendrocyte Glycoprotein; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*
chemical_list: D017931:DNA Primers; C571326:MOG protein, human; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein