title: Intersurf: dynamic interface between proteins.
abstract: Protein docking is a fundamental biological process that links two proteins. This link is typically defined by an interaction between two large zones of the protein boundaries. Visualizing such an interface is useful to understand the process thanks to 3D protein structures, to estimate the quality of docking simulation results, and to classify interactions in order to predict docking affinity between classes of interacting zones. Since the interface may be defined by a surface that separates the two proteins, it is possible to create a map of interaction that allows comparisons to be performed in 2D. This paper presents a very fast algorithm that extracts an interface surface and creates a valid and low-distorted interaction map. Another benefit of our approach is that a pre-computed part of the algorithm enables the surface to be updated in real-time while residues are moved.
authors.affiliation: Project Isa, Inria Lorraine, 615 rue du Jardin Botanique, BP 101, 54602 Villers-les-Nancy Cedex, France. nicolas.ray@loria.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Ray
authors.forename: Xavier
authors.initials: X
authors.lastname: Cavin
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Paul
authors.forename: Bernard
authors.initials: B
authors.lastname: Maigret
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D008958:Models, Molecular; D011487:Protein Conformation; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry*; D012984:Software
chemical_list: D011506:Proteins