Stimulation of immunotoxicity of chemicals metabolizing in vivo into highly toxic compounds by the monooxygenase system inductors.
Oral treatment of experimental random-bred albino rats with inductors of the monooxygenase system phenobarbital (50 mg/kg) and benzenal (70 mg/kg) for 3 days until acute poisoning with toxins (methanol, ethylene glycol, and dichloroethane in doses of 1.0 LD50) metabolizing in the body to compounds with higher toxicity (phenomenon of lethal synthesis) increased immunotoxicity of these inductors.
Zabrodskii
P F
PF
Saratov Military Institute of Radiation, Chemical, and Biological Protection.
Troshkin
N M
NM
Mandych
V G
VG
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001547:Benzaldehydes / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D005025:Ethylene Dichlorides / Q000378:metabolism / Q000633:toxicity; D019855:Ethylene Glycol / Q000378:metabolism / Q000633:toxicity; D005260:Female; D000922:Immunotoxins / Q000378:metabolism* / Q000633:toxicity*; D008297:Male; D000432:Methanol / Q000378:metabolism / Q000633:toxicity; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D001547:Benzaldehydes; D005025:Ethylene Dichlorides; D000922:Immunotoxins; D003577:Cytochrome P-450 Enzyme System; D019855:Ethylene Glycol; C032175:benzaldehyde; D000432:Methanol; D010634:Phenobarbital