title: [A possible mechanism of participation of dopaminergic cells and striatal cholinergic interneurons in the conditioned selection of motor activity].
abstract: A possible mechanism of participation of cholinergic striatal interneurons and dopaminergic cells in conditioned selection of a certain types of motor activity is proposed. This selection is triggered by simultaneous increase in the activity of dopaminergic cells and a pause in the activity of cholinergic interneurons in response to a conditioned stimulus. This pause is promoted by activation of striatal inhibitory interneurons and action of dopamine at D2 receptors on cholinergic cells. Opposite changes in dopamine and acetylcholine concentration synergistically modulate the efficacy of corticostriatal inputs, modulation rules for the "strong" and "weak" corticostriatal inputs are opposite. Subsequent reorganization of neuronal firing in the loop cortex--basal ganglia--thalamus--cortex results in amplification of activity of the group of cortical neurons that strongly activate striatal cells, and simultaneous suppression of activity of another group of cortical neurons that weakly activate striatal cells. These changes can underlie a conditioned selection of motor activity performed with involvement of the motor cortex. As follows from the proposed model, if the time delay between conditioned and unconditioned stimuli does not exceed the latency of responses of dopaminergic and cholinergic cells (about 100 ms), conditioned selection of motor activity and learning is problematic.
authors.forename: I G
authors.initials: IG
authors.lastname: Sil'kis
mesh_terms: D000109:Acetylcholine / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D003213:Conditioning, Psychological / Q000502:physiology; D003342:Corpus Striatum / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007395:Interneurons / Q000378:metabolism / Q000502:physiology*; D007858:Learning / Q000502:physiology; D008959:Models, Neurological; D009043:Motor Activity / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000378:metabolism / Q000502:physiology*; D013788:Thalamus / Q000378:metabolism / Q000502:physiology
chemical_list: D017448:Receptors, Dopamine D2; D000109:Acetylcholine