title: Antinociceptive action of hemopressin in experimental hyperalgesia.
abstract: Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the alpha-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied. In this work, we examined the influence of hemopressin on inflammatory pain. Hemopressin reverted the hyperalgesia induced by either carrageenin or bradykinin when injected concomitantly or 2.5 h after the phlogistic agents. Hemopressin administered systemically also reverted the hyperalgesia induced by carrageenin. Naloxone did not prevent the antinociceptive action of this peptide. These data suggest that hemopressin inhibits peripheral hyperalgesic responses by mechanisms independent of opioid receptor activation.
authors.affiliation: Laboratory of Pathophysiology, Butantan Institute, São Paulo, SP, Brazil.
authors.forename: Camila Squarzoni
authors.initials: CS
authors.lastname: Dale
authors.forename: Rosana de Lima
authors.initials: Rde L
authors.lastname: Pagano
authors.forename: Vanessa
authors.initials: V
authors.lastname: Rioli
authors.forename: Stephen
authors.initials: S
authors.lastname: Hyslop
authors.forename: Renata
authors.initials: R
authors.lastname: Giorgi
authors.forename: Emer Suavinho
authors.initials: ES
authors.lastname: Ferro
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure; D001920:Bradykinin / Q000494:pharmacology; D002351:Carrageenan / Q000494:pharmacology; D004195:Disease Models, Animal; D004723:Endorphins; D006454:Hemoglobins / Q000737:chemistry / Q000494:pharmacology*; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D007249:Inflammation; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010146:Pain; D010147:Pain Measurement; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000737:chemistry; D013997:Time Factors
chemical_list: D000700:Analgesics; D004723:Endorphins; D006454:Hemoglobins; D009292:Narcotic Antagonists; D010446:Peptide Fragments; D010455:Peptides; D011957:Receptors, Opioid; C473218:hemopressin; D009270:Naloxone; D002351:Carrageenan; D001920:Bradykinin