Preliminary study of the in vitro interaction between alcohol, high-dose flunitrazepam and its three metabolites using human liver microsomes.
Tanaka
Einosuke
E
Institute of Community Medicine, University of Tsukuba, Ibaraki-ken 305-8575, Japan. einosuke@md.tsukuba.ac.jp
Nakamura
Takako
T
Terada
Tasaru
T
Shinozuka
Tatsuo
T
Honda
Katsuya
K
D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics*; D001711:Biotransformation; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005445:Flunitrazepam / Q000493:pharmacokinetics*; D006801:Humans; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
D014151:Anti-Anxiety Agents; D002492:Central Nervous System Depressants; D000431:Ethanol; D005445:Flunitrazepam