CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance.
Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX3CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX3CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.
Niess
Jan Hendrik
JH
Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Brand
Stephan
S
Gu
Xiubin
X
Landsman
Limor
L
Jung
Steffen
S
McCormick
Beth A
BA
Vyas
Jatin M
JM
Boes
Marianne
M
Ploegh
Hidde L
HL
Fox
James G
JG
Littman
Dan R
DR
Reinecker
Hans-Christian
HC
D000818:Animals; D000073883:CX3C Chemokine Receptor 1; D054428:Chemokine CX3CL1; D020523:Chemokines, CX3C / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000382:microbiology; D004926:Escherichia coli / Q000276:immunology* / Q000302:isolation & purification; D017353:Gene Deletion; D049452:Green Fluorescent Proteins / Q000378:metabolism; D007082:Ileum / Q000166:cytology / Q000276:immunology; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology; D007421:Intestine, Small / Q000276:immunology / Q000382:microbiology; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D010581:Peyer's Patches / Q000276:immunology / Q000382:microbiology; D010587:Phagocytosis; D019707:Receptors, Chemokine / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012481:Salmonella Infections, Animal / Q000276:immunology* / Q000382:microbiology; D012486:Salmonella typhimurium / Q000276:immunology* / Q000302:isolation & purification
D000073883:CX3C Chemokine Receptor 1; D054428:Chemokine CX3CL1; D020523:Chemokines, CX3C; C515539:Cx3cl1 protein, mouse; C471885:Cx3cr1 protein, mouse; D008565:Membrane Proteins; D019707:Receptors, Chemokine; D049452:Green Fluorescent Proteins