title: Targeting Ras and Rho GTPases as opportunities for cancer therapeutics.
abstract: The Ras and Rho GTPases contribute to the initiation and progression of cancer by subverting the normal regulation of specific intracellular signalling pathways. As a result, Ras and Rho play significant roles in the development of numerous aspects of the malignant phenotype by promoting cell cycle progression, resistance to apoptotic stimuli, neo-vascularisation and tumour cell motility, invasiveness and metastasis. With these GTPases contributing at so many levels, they are appealing targets for the development of cancer chemotherapeutic agents.
authors.affiliation: The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
authors.forename: Katharine
authors.initials: K
authors.lastname: Walker
authors.forename: Michael F
authors.initials: MF
authors.lastname: Olson
mesh_terms: D000818:Animals; D004164:Diphosphonates / Q000494:pharmacology; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D011496:Protein Methyltransferases / Q000037:antagonists & inhibitors; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D018631:ras Proteins / Q000037:antagonists & inhibitors*; D020741:rho GTP-Binding Proteins / Q000037:antagonists & inhibitors*
chemical_list: D004164:Diphosphonates; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011496:Protein Methyltransferases; C056501:protein-S-isoprenylcysteine O-methyltransferase; D010450:Endopeptidases; D018631:ras Proteins; D020741:rho GTP-Binding Proteins