title: Letrozole significantly improves growth potential in a pubertal boy with growth hormone deficiency.
abstract: Clinical experience with using an aromatase inhibitor to suppress estrogen production during puberty for improvement of growth potential in adolescents with short stature is limited. This report documents treatment of such a patient with a combination of growth hormone and letrozole, a third-generation aromatase inhibitor. Our case demonstrates a favorable outcome on a short-term basis.
authors.affiliation: Division of Pediatric Endocrinology, New York University School of Medicine, New York, New York 10016, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Bina
authors.initials: B
authors.lastname: Shah
authors.forename: Kris
authors.initials: K
authors.lastname: Prasad
authors.forename: Raphael
authors.initials: R
authors.lastname: David
mesh_terms: D000293:Adolescent; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D004359:Drug Therapy, Combination; D006130:Growth Disorders / Q000097:blood / Q000188:drug therapy*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D000077289:Letrozole; D008055:Lipids / Q000097:blood; D008297:Male; D009570:Nitriles / Q000627:therapeutic use*; D013739:Testosterone / Q000097:blood; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D047072:Aromatase Inhibitors; D015415:Biomarkers; D008055:Lipids; D009570:Nitriles; D014230:Triazoles; D019382:Human Growth Hormone; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D000077289:Letrozole