Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination.
We examined associations between human leukocyte antigen (HLA) class II genes and both rubella-specific immunoglobulin G antibodies and lymphoproliferative responses after measles-mumps-rubella-II (MMR-II) vaccination, in a population-based sample of 346 schoolchildren. The DPB1*0301, DPB1*0401, DPB1*1301, and DPB1*1501 alleles were significantly associated with rubella vaccine-induced antibodies. Alleles suggestive of being positively associated with rubella-specific lymphoproliferative stimulation indices were DPB1*0301, DQB1*0501, DRB1*0101, and DRB1*1104. Conversely, the DPB1*0401, DPB1*1001, DPB1*1101, DQB1*0202, and DRB1*0701 alleles were negatively associated with rubella-specific lymphoproliferation. This study of HLA class II-restricted humoral and cellular immune responses to rubella provides significant insight into mechanisms of vaccine response and new vaccine development.
Ovsyannikova
Inna G
IG
Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
Jacobson
Robert M
RM
Vierkant
Robert A
RA
Jacobsen
Steven J
SJ
Pankratz
V Shane
VS
Poland
Gregory A
GA
D000293:Adolescent; D000483:Alleles; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D005260:Female; D005802:Genes, MHC Class II; D006682:HLA-DP Antigens / Q000235:genetics; D059868:HLA-DP beta-Chains; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008213:Lymphocyte Activation; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000276:immunology*; D012412:Rubella virus / Q000276:immunology*; D014611:Vaccination
D000914:Antibodies, Viral; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D007074:Immunoglobulin G; D022542:Measles-Mumps-Rubella Vaccine; C040901:rubella antibodies