Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection.
Infections of T cells and natural killer (NK) cells play a central role in the pathogenesis of chronic active Epstein-Barr virus (CAEBV) infection. To characterize the virologic and cytokine profiles of T cell-type and NK cell-type infection, 39 patients with CAEBV infection were analyzed. Patients with T cell-type infection had higher titers of immunoglobulin G against early and late EBV antigens, suggesting lytic cycle infection. However, the pattern of EBV gene expression was latency type II; BZLF1, which is a hallmark of lytic cycle infection, could not be detected in any patients, regardless of infection type. Patients with CAEBV infection had high concentrations of proinflammatory, T helper cell type 1, and anti-inflammatory cytokines. The cytokine profile in patients with NK cell-type infection was similar to that in patients with T cell-type infection, but the concentration of IL-13 was high in patients with NK cell-type infection. These findings should help to clarify the pathogenesis of CAEBV infection and facilitate the development of more-effective treatments.
Kimura
Hiroshi
H
Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. hkimura@med.nagoya-u.ac.jp
Hoshino
Yo
Y
Hara
Shinya
S
Sugaya
Naomi
N
Kawada
Jun-Ichi
J
Shibata
Yukiko
Y
Kojima
Seiji
S
Nagasaka
Tetsuro
T
Kuzushima
Kiyotaka
K
Morishima
Tsuneo
T
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood; D004268:DNA-Binding Proteins / Q000097:blood; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D018793:Interleukin-13 / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology / Q000821:virology*; D016131:Lymphocyte Subsets / Q000276:immunology / Q000821:virology; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology*; D015534:Trans-Activators / Q000097:blood; D014764:Viral Proteins / Q000097:blood
D000914:Antibodies, Viral; D000956:Antigens, Viral; C063676:BZLF1 protein, Herpesvirus 4, Human; D016207:Cytokines; D004268:DNA-Binding Proteins; D007074:Immunoglobulin G; D018793:Interleukin-13; D015534:Trans-Activators; D014764:Viral Proteins