An efficient asymmetric synthesis of (S)-atenolol: using hydrolytic kinetic resolution.
Enantiomerically pure (S)-atenolol was prepared by using (R,R) salen Co(III) complex for the resolution of terminal epoxide. This process was carried out at room temperature in excellent enantio selectivity. The method can be applied for large-scale preparation of (S)-atenolol without any problem.
Bose
D Subhas
DS
Division of Organic Chemistry, Fine Chemicals Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India. vnakkirala2001@yahoo.com
Venkat Narsaiah
A
A
D001262:Atenolol / Q000138:chemical synthesis*; D006868:Hydrolysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
D001262:Atenolol