title: Investigations on the synthesis and pharmacological properties of N-substituted derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones.
abstract: Synthesis of N-substituted derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones (10-14, 18-21) is described. In the "writhing syndrome" test all compounds studied exhibited potent analgesic activity which was superior than that of acetylsalicylic acid. In the "hot plate" test imides 10, 12, 13, 18-20 acted also stronger than aspirin. Furthermore all compounds tested significantly suppressed the spontaneous locomotor activity of mice and prolonged barbiturate sleep of these animals.
authors.affiliation: Department of Chemistry of Drugs, Wrocław University of Medicine, Tamka 1, 50-137 Wrocław, Poland. helena@bf.uni.wroc
authors.forename: Helena
authors.initials: H
authors.lastname: Sladowska
authors.forename: Barbara
authors.initials: B
authors.lastname: Filipek
authors.forename: Dominika
authors.initials: D
authors.lastname: Szkatuła
authors.forename: Jacek
authors.initials: J
authors.lastname: Sapa
authors.forename: Marek
authors.initials: M
authors.lastname: Bednarski
authors.forename: Marta
authors.initials: M
authors.lastname: Ciołkowska
mesh_terms: D000698:Analgesia; D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D011758:Pyrroles