Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice.
Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.
Ilhan
Atilla
A
Inonu University Medical Faculty, Department of Neurology, Turgut Ozal Medical Center, Malatya, Turkey. ailhan@inonu.edu.tr
Iraz
Mustafa
M
Gurel
Ahmet
A
Armutcu
Ferah
F
Akyol
Omer
O
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers; D002109:Caffeic Acids / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects* / Q000473:pathology; D003292:Convulsants; D005260:Female; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism; D018696:Neuroprotective Agents; D009569:Nitric Oxide / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D010433:Pentylenetetrazole; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
D000975:Antioxidants; D015415:Biomarkers; D002109:Caffeic Acids; D003292:Convulsants; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D016877:Oxidants; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol; D010433:Pentylenetetrazole