title: Potential clinical impact of variability in the measurement of coronary artery calcification with sequential MDCT.
abstract: OBJECTIVE
  The potential clinical impact of variability in the measurement of coronary artery calcification with sequential MDCT was evaluated using Agatston, volume, and mass scoring algorithms.
  
  
  METHODS
  Fifty-six patients were imaged twice using an identical prospectively ECG-triggered sequential scanning protocol. The Agatston, volume, and mass scores were computed by two observers independently. In addition, a patient's total Agatston score was referenced to an age- and sex-stratified database to determine a percentile ranking. Interscan, interobserver, and intraobserver variability and the resultant impact on patients' risk stratifications were assessed.
  
  
  RESULTS
  Significant interscan differences were found for all mean coronary calcium scores (Wilcoxson's signed rank test, p <0.0001). Although the median percentage of interscan variability was low for all scoring methods, the interquartile range was wide, indicating significant variability in the data. Median scores (lower quartile-upper quartile) for observers 1 and 2, respectively, were as follows: Agatston, 5% (0-79%) and 6% (0-83%); volume, 12% (0-51%) and 12% (0-57%); and mass, 14% (0-57%) and 14% (0-58%). Interobserver and intraobserver differences between mean calcium scores were not significant, and consequently, lower interobserver and intraobserver variabilities (narrow interquartile ranges of 0-5%) were observed for all scores. Despite significant interscan differences in calcium scores, the percentile ranking assigned to the two scans differed in only 13% of patients. Interobserver differences resulted in a change in the percentile ranking in 7-9% of patients, whereas intraobserver differences caused a change in only 5% of patients.
  
  
  CONCLUSIONS
  The accuracy of sequential MDCT for coronary calcium quantification is sufficient in most cases for stratification of patient risk.
authors.affiliation: Section of Cardiovascular Imaging, Division of Radiology/Hb6, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA. hallibs@ccf.org
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Halliburton
authors.forename: Arthur E
authors.initials: AE
authors.lastname: Stillman
authors.forename: Michael
authors.initials: M
authors.lastname: Lieber
authors.forename: Jane M
authors.initials: JM
authors.lastname: Kasper
authors.forename: Stacie A
authors.initials: SA
authors.lastname: Kuzmiak
authors.forename: Richard D
authors.initials: RD
authors.lastname: White
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D002114:Calcinosis; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*