In vitro effect of acetylcholine on function of sinoatrial node in rat heart.
Electrophysiological parameters of true pacemakers in the sinoatrial node of rat heart were recorded intracellularly using glass microelectrodes. In 11 of 13 experiments acetylcholine in increasing doses did not induce migration of the dominant pacemaker region, while in two cases its minor migration upstream the sinus node artery was observed.
Sutyagin
P V
PV
Department of Morphology, Russian State Medical University, Moscow. charyeva@yandex.ru
Kalinina
E E
EE
Pylaev
A S
AS
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003864:Depression, Chemical; D066298:In Vitro Techniques; D008297:Male; D008839:Microelectrodes; D051381:Rats; D017208:Rats, Wistar; D012849:Sinoatrial Node / Q000187:drug effects* / Q000502:physiology*
D000109:Acetylcholine