Redoxing calcium from the ER.
Inositol 1,4,5-trisphosphate (InsP(3))-induced calcium release from the endoplasmic reticulum (ER) intracellular calcium store regulates cellular functions from the beginning of life at fertilization until death. In this issue of Cell, Mikoshiba and colleagues describe a novel mode of regulation of the InsP(3) receptor (InsP(3)R) governed by ER luminal redox status, calcium, and pH .
Roderick
H Llewelyn
HL
Laboratory for Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT, United Kingdom.
Bootman
Martin D
MD
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism* / Q000494:pharmacology; D053496:Inositol 1,4,5-Trisphosphate Receptors; D010084:Oxidation-Reduction; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium