title: Blood pressure change with age in salt-sensitive teenagers.
abstract: OBJECTIVE
  To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.
  
  
  METHODS
  Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.
  
  
  RESULTS
  After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7 +/- 12.1 mmHg vs. 2.8 +/- 5.2 mmHg, P < 0.01; 12.2% +/- 12.0% vs. 2.5% +/- 4.4%, P < 0.001, respectively). There was a similar trend for diastolic blood pressure (8.4 +/- 6.4 mmHg vs. 3.7 +/- 6.4 mmHg, P = 0.052; 13.2% +/- 10.6% vs. 6.8% +/- 10.1%, P = 0.053, respectively).
  
  
  CONCLUSIONS
  Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.
authors.affiliation: Department of Cardiology, First Hospital of Xi'an Jiaotong University, Xi'an 710061. yetao8@sina.com
authors.forename: Tao
authors.initials: T
authors.lastname: Ye
authors.forename: Zhi-quan
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Mu
authors.forename: Xi-han
authors.initials: XH
authors.lastname: Fu
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Bao-lin
authors.initials: BL
authors.lastname: Gao
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects*; D001810:Blood Volume; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D013599:Systole
chemical_list: D012965:Sodium Chloride; D005665:Furosemide