title: Genetic study of the CD36 gene in a French diabetic population.
abstract: OBJECTIVE
  CD36 is a multifunctional membrane receptor widely expressed in different tissues which binds and internalizes oxidized low-density lipoprotein. In rodents, CD36 gene variations modulate glucose homeostasis and contribute to metabolic syndrome associated with type 2 diabetes but the effects in human are unknown.
  
  
  METHODS
  We screened the entire coding sequence of the CD36 gene in 272 individuals and we genotyped both rare and frequent variants in 454 T2D subjects and 221 controls.
  
  
  RESULTS
  We detected five mutations, P191P and N247S were only found each in one family and did not segregate with diabetes, the three others (A/C-178 in the promoter, A/G-10 in intron 3 and (GGGTTGAGA) insertion in intron 13) being equally frequent in diabetic subjects and in controls. However, adiponectin levels, a marker for insulin sensitivity, were significantly associated with the -178 A/C promoter variant allele (p=0.003, p corrected for multiple testing=0.036), possibly reflecting association with insulin-resistance in the French population.
  
  
  CONCLUSIONS
  Thus, the -178 A/C SNP promoter mutation in the CD36 gene represents a putative genetic marker for insulin-resistance in the French population, although it does not appear to contribute to the genetic risk for T2D.
authors.affiliation: Institute of Biology-CNRS 8090, Pasteur Institute of Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Leprêtre
authors.forename: K J
authors.initials: KJ
authors.lastname: Linton
authors.forename: C
authors.initials: C
authors.lastname: Lacquemant
authors.forename: V
authors.initials: V
authors.lastname: Vatin
authors.forename: C
authors.initials: C
authors.lastname: Samson
authors.forename: C
authors.initials: C
authors.lastname: Dina
authors.forename: M
authors.initials: M
authors.lastname: Chikri
authors.forename: S
authors.initials: S
authors.lastname: Ali
authors.forename: P
authors.initials: P
authors.lastname: Scherer
authors.forename: K
authors.initials: K
authors.lastname: Séron
authors.forename: F
authors.initials: F
authors.lastname: Vasseur
authors.forename: T
authors.initials: T
authors.lastname: Aitman
authors.forename: P
authors.initials: P
authors.lastname: Froguel
mesh_terms: D052242:Adiponectin; D001483:Base Sequence; D018955:CD36 Antigens / Q000235:genetics*; D003920:Diabetes Mellitus / Q000235:genetics* / Q000276:immunology; D005091:Exons / Q000235:genetics; D005602:France; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood; D007438:Introns / Q000235:genetics; D009154:Mutation; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011401:Promoter Regions, Genetic; D012016:Reference Values
chemical_list: D052242:Adiponectin; D018955:CD36 Antigens; D036341:Intercellular Signaling Peptides and Proteins