Plasma concentration for optimal sedation and total body clearance of propofol in patients after esophagectomy.
The present study investigated plasma propofol concentration for optimal sedation and total body clearance in patients who required sedation for mechanical ventilation after esophagectomy. Seven patients after esophagectomy were enrolled in this study. Plasma propofol concentrations were measured with high performance liquid chromatography. Total body clearance was calculated from the steady-state concentration. The infusion rate of propofol for achieving the sedation score of level 3 (drowsy, responds to verbal stimulation) was 1.74 +/- 0.82 mg kg(-1) h(-1) (mean +/- SD, n = 7) when the plasma propofol concentration and the total body clearance were 0.85 +/- 0.24 microg ml(-1) and 1.83 +/- 0.54 l min(-1) (mean +/- SD, n =7), respectively.
Takizawa
Daisuke
D
Intensive Care Unit, Gunma University Hospital, Maebashi, Japan.
Sato
Eri
E
Nishikawa
Koichi
K
Hinohara
Hiroshi
H
Hiraoka
Haruhiko
H
Saito
Shigeru
S
Goto
Fumio
F
Kunimoto
Fumio
F
D000328:Adult; D018686:Anesthetics, Intravenous / Q000097:blood* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D016292:Procedural Sedation; D016629:Esophagectomy; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D015742:Propofol / Q000097:blood* / Q000493:pharmacokinetics; D012121:Respiration, Artificial
D018686:Anesthetics, Intravenous; D015742:Propofol