Effect of in vivo hypoxic preconditioning on changes in intracellular calcium content induced by long-term anoxia in rat brain slices.
We studied changes in intracellular calcium content induced by 10-min anoxia in olfactory cortex slices from rats exposed to single or 3-fold moderate hypobaric hypoxia ("ascend" at 5000 m). Repeated preconditioning with moderate hypobaric hypoxia produced a neuroprotective effect. This treatment abolished pathological calcium overload in brain slices induced in vitro by 10-min test anoxia.
Semenov
D G
DG
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Miller
O L
OL
Samoilov
M O
MO
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000378:metabolism* / Q000517:prevention & control; D066298:In Vitro Techniques; D007424:Intracellular Fluid / Q000378:metabolism; D019194:Ischemic Preconditioning / Q000379:methods; D008297:Male; D009833:Olfactory Pathways / Q000378:metabolism; D051381:Rats; D011921:Rats, Inbred WKY; D013997:Time Factors
D002118:Calcium