title: Childhood cancer survivors: an at-risk cohort for ankle osteonecrosis.
abstract: We aimed to determine if the ankle is at risk for corticosteroid-induced osteonecrosis as a cause of pain in a cohort of childhood cancer survivors. We retrospectively reviewed magnetic resonance imaging scans of the ankle in patients treated at our institution between 1993 and 2003. Among the 15 patients who met study criteria, 20 of 30 (67%) ankles were involved. Older children had the highest incidence of the disease. The tibial metaphysis, epiphysis, and talus were the most frequent sites of osteonecrotic lesions. Ten patients were symptomatic with extended weightbearing activity. Surgery was required in four with continued amelioration of pain at last followup (17-44 months). As early detection and intervention lead to prevention of ankle morbidity, childhood cancer survivors would benefit from a prospective multi-institutional study that would provide understanding of ankle osteonecrosis and development of effective interventions.
  
  
  METHODS
  Prognostic study, Level II-1 (retrospective study).
authors.affiliation: Department of Radiological Sciences, Division of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.
authors.forename: Casey T
authors.initials: CT
authors.lastname: Chollet
authors.forename: Lunetha
authors.initials: L
authors.lastname: Britton
authors.forename: Michael D
authors.initials: MD
authors.lastname: Neel
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Hudson
authors.forename: Sue C
authors.initials: SC
authors.lastname: Kaste
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D000843:Ankle Joint; D018771:Arthralgia / Q000453:epidemiology; D015984:Causality; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000453:epidemiology; D010020:Osteonecrosis / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D017741:Survivors / Q000706:statistics & numerical data*; D013714:Tennessee / Q000453:epidemiology
chemical_list: D005938:Glucocorticoids