title: Transforming growth factor-{beta} regulates susceptibility of epithelial apoptosis in murine model of colitis.
abstract: Transforming growth factor (TGF)-beta has a key role in intestinal homeostasis. Our present data suggest that TGF-beta, which was constitutively expressed by lamina propria mononuclear cells and epithelium, affected epithelial cells. Abnormal suppression of TGF-beta could enhance the sensitivity of epithelial cells to apoptosis associated with interferon-gamma in DSS-induced colitis.
authors.affiliation: First Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan. hirotake@infoaomori.ne.jp
authors.forename: Hirotake
authors.initials: H
authors.lastname: Sakuraba
authors.forename: Yoh
authors.initials: Y
authors.lastname: Ishiguro
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Yamagata
authors.forename: Yoh-Ichi
authors.initials: Y
authors.lastname: Tagawa
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Iwakura
authors.forename: Kenji
authors.initials: K
authors.lastname: Sekikawa
authors.forename: Akihiro
authors.initials: A
authors.lastname: Munakata
authors.forename: Akio
authors.initials: A
authors.lastname: Nakane
mesh_terms: D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology*; D051379:Mice; D016212:Transforming Growth Factor beta / Q000502:physiology*
chemical_list: D016212:Transforming Growth Factor beta; D016264:Dextran Sulfate