Integrated control of Boophilus microplus ticks in Cuba based on vaccination with the anti-tick vaccine Gavac.
Boophilus microplus has developed resistance against a range of chemical acaricides which has stimulated the development of alternative methods such as vaccination against ticks. In Cuba, the Bm86-based recombinant vaccine Gavac has been successfully used in a number of controlled laboratory and field trials in cattle against B. microplus. In this paper, we have evaluated Gavac in a large scale field trial wherein 588,573 dairy cattle were vaccinated with the aim to reduce the number of acaricidal treatments. It was found that the number of acaricidal treatments could be reduced by 87% over a period of 8 years (1995--2003). Prior to the introduction of the vaccine, 54 clinical cases of babesiosis and six fatal cases were reported per 1000 animals. Six years later, the incidence of babesiosis was reduced to 1.9 cases per 1000 cattle and mortality reduced to 0.18 per 1000. The national consumption of acaricides in Cuba could be reduced by 82% after the implementation of the integrated anti-B. microplus control program.
Valle
Manuel Rodriguez
MR
Centro de Ingeniería Genéticay Biotecnología, Cubanacan, Playa, Havana, Cuba. mrodriguez@cigb.edu.cu
Mèndez
Luis
L
Valdez
Mario
M
Redondo
Miguel
M
Espinosa
Carlos Montero
CM
Vargas
Milagro
M
Cruz
Ricardo Lleonart
RL
Barrios
Humberto Perez
HP
Seoane
Guillermo
G
Ramirez
Emerio Serrano
ES
Boue
Oscar
O
Vigil
Jorge Lodos
JL
Machado
Héctor
H
Nordelo
Carlos Borroto
CB
Piñeiro
Marisdania Joglar
MJ
D000818:Animals; D001404:Babesiosis / Q000517:prevention & control; D002417:Cattle; D002418:Cattle Diseases / Q000469:parasitology / Q000517:prevention & control; D003462:Cuba; D007300:Insect Control / Q000379:methods*; D007306:Insecticides; D026863:Ixodidae / Q000276:immunology / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology*; D013984:Tick Infestations / Q000517:prevention & control / Q000662:veterinary*; D013997:Time Factors; D014612:Vaccines / Q000276:immunology*
C085065:BM86 protein, Boophilus; D007306:Insecticides; D008562:Membrane Glycoproteins; D011994:Recombinant Proteins; D014612:Vaccines