MicroRNA biogenesis: drosha can't cut it without a partner.
The ribonuclease Drosha requires a dedicated double-stranded RNA binding protein to convert long, nuclear primary microRNA transcripts into shorter pre-microRNA stem-loops, the cytoplasmic precursors from which mature microRNAs are ultimately excised.
Tomari
Yukihide
Y
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Zamore
Phillip D
PD
D000818:Animals; D006801:Humans; D005786:Gene Expression Regulation; D035683:MicroRNAs / Q000096:biosynthesis / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D043244:Ribonuclease III / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism
C474043:DGCR8 protein, human; C517918:DROSHA protein, human; D035683:MicroRNAs; D011506:Proteins; D043244:Ribonuclease III; D016601:RNA-Binding Proteins