title: Stereoselective oxidation of protected inositol derivatives catalyzed by inositol dehydrogenase from Bacillus subtilis.
abstract: Inositol dehydrogenase (EC 1.1.1.18) from Bacillus subtilis is shown to have a nonpolar cavity adjacent to the active site, allowing racemic protected inositol derivatives such as 4-O-benzyl-myo-inositol to be recognized with very high apparent stereoselectivity.
authors.affiliation: Department of Chemistry, University of Saskatchewan, Canada.
authors.forename: Richard
authors.initials: R
authors.lastname: Daniellou
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Phenix
authors.forename: Pui Hang
authors.initials: PH
authors.lastname: Tam
authors.forename: Michael C
authors.initials: MC
authors.lastname: Laliberte
authors.forename: David R J
authors.initials: DR
authors.lastname: Palmer
mesh_terms: D001412:Bacillus subtilis / Q000201:enzymology*; D002236:Carbohydrate Conformation; D002384:Catalysis; D007294:Inositol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013401:Sugar Alcohol Dehydrogenases / Q000737:chemistry*
chemical_list: D007294:Inositol; D013401:Sugar Alcohol Dehydrogenases; C021448:myo-inositol 2-dehydrogenase