Quantal transmission: not just for neurons.
Glia have moved into the spotlight as participants in synaptic signaling. Recent work by Bergles and colleagues extends this active role by showing that oligodendrocyte precursors cells (OPCs) in the hippocampus receive functional glutamatergic and GABAergic synapses. Synaptic signaling in these cells could provide a mechanism for activity-dependent modulation of OPC proliferation and differentiation.
Overstreet
Linda S
LS
Vollum Institute, L474, Oregon Health & Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. overstre@ohsu.edu
D000818:Animals; D002450:Cell Communication / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism; D009433:Neural Inhibition; D009474:Neurons / Q000502:physiology*; D009836:Oligodendroglia / Q000502:physiology; D013234:Stem Cells / Q000502:physiology; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid