title: Intracellular signalling and cancer: complex pathways lead to multiple targets.
abstract: Normal cells proliferate, die and differentiate as and when they should for the proper functioning of any particular tissue type. These processes are governed by a complex series of intracellular pathways that have many internal checkpoints and safety nets. These ensuring a fine, but tight, balance on overall tissue growth and distribution. A series of key aberrations, resulting in the disruption of these intracellular pathways, can lead to the development of a malignancy. The nature of these alterations is often not only tumour-specific, but also different between individuals with the same tumour type. As a result, these pathways have to be carefully dissected and functionally assessed to identify valid targets with therapeutic potential in a wide range of tumour types.
authors.affiliation: Tumour Cell Death Laboratory, Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
authors.forename: Helen S
authors.initials: HS
authors.lastname: Bell
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Ryan
mesh_terms: D016923:Cell Death / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000473:pathology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D020794:Receptor Protein-Tyrosine Kinases