title: Late solitary bone metastasis of a primary pulmonary synovial sarcoma with SYT-SSX1 translocation type: case report with a long follow-up.
abstract: Primary synovial sarcoma outside its classical presentation in para-articular soft tissue of young patients is rare but regularly reported. One of the rarest primary locations is the lung. We describe a 73-year-old female patient who presented with a solitary malignant bone tumor 8 years after the resection of a lung neoplasm. The bone tumor was classified as an osteosarcoma and the lung tumor as an atypical carcinoid tumor at their first respective diagnostic work-ups. The resection of the affected humerus with allograft and endoprosthesis implantation followed. Reevaluation of the tumor samples at the time of the local recurrence of the bone tumor 6 years following the initial symptoms of the bone tumor lead to the reclassification of both specimens as synovial sarcomas. Both neoplasms contained the SYT-SSX1 type of the diagnostic translocation t(X;18) as detected by the reverse-transcription polymerase chain reaction analysis. The patient died 14 years after the resection of the primary synovial sarcoma of the lung and 6 years following the occurrence of the bone metastasis. This prolonged clinical course is uncommon for the SYT-SSX1 translocation, which, in other locations, is usually associated with an unfavorable prognosis.
authors.affiliation: Department of Pathology, University Hospital Zurich, 8091 Zurich, Switzerland. beata.bode@usz.ch
authors.forename: B
authors.initials: B
authors.lastname: Bode-Lesniewska
authors.forename: J
authors.initials: J
authors.lastname: Hodler
authors.forename: A
authors.initials: A
authors.lastname: von Hochstetter
authors.forename: L
authors.initials: L
authors.lastname: Guillou
authors.forename: U
authors.initials: U
authors.lastname: Exner
authors.forename: R
authors.initials: R
authors.lastname: Caduff
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology*; D015514:Oncogene Proteins, Fusion; D012516:Osteosarcoma / Q000473:pathology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013584:Sarcoma, Synovial / Q000235:genetics* / Q000473:pathology / Q000556:secondary*; D013997:Time Factors; D014178:Translocation, Genetic
chemical_list: D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein