title: Trichoblastoma with apocrine and sebaceous differentiation.
abstract: Trichoblastoma is a rare, benign tumor that differentiates toward the hair germ, the embryonic precursor of a hair follicle. Several cases of trichoblastoma showed multiple differentiation toward more than one type of adnexal structure. We report a case of a trichoblastoma, which had developed on the scalp as a solitary 1-cm nodule 3 years ago. A histologic examination indicated that the specimen had features of multiple differentiation. In particular, there were occasional foci of decapitation secretion, as well as cells with web-like and bubbly cytoplasm suggesting seboblasts, and a sebaceous duct-like structure. In addition, there were occasional germinative cells in the palisade, and scattered hair papilla-like structures showing follicular differentiation. An immunohistochemical study showed that the neoplasm, or areas in it, stained positive for low molecular cytokeratin, high molecular cytokeratin, EMA, S-100, and GCDFP-15. This is an unusual case of a trichoblastoma with apocrine and sebaceous differentiation.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Dong Kee
authors.initials: DK
authors.lastname: Yu
authors.forename: Young Hyun
authors.initials: YH
authors.lastname: Joo
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Cho
mesh_terms: D001050:Apocrine Glands / Q000378:metabolism / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D005260:Female; D006201:Hair Diseases / Q000378:metabolism / Q000473:pathology*; D018859:Hair Follicle / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D018294:Neoplasms, Adnexal and Skin Appendage / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D012627:Sebaceous Glands / Q000378:metabolism / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor