title: Complete small-bowel transit in patients undergoing capsule endoscopy: determining factors and improvement with metoclopramide.
abstract: BACKGROUND
  Passage of the capsule endoscope to the colon occurs in only approximately three quarters of patients. This study assessed factors that might influence the completeness of small-bowel transit, including orally administered metoclopramide.
  
  
  METHODS
  Clinical and procedural parameters were recorded prospectively for 150 patients undergoing capsule endoscopy. Metoclopramide was not administered to the first 83 patients (Group 1) but was given orally (10 mg) to the subsequent 67 (Group 2).
  
  
  RESULTS
  Small-bowel transit was complete in 63 patients in Group 1 (76%). Gastric transit time was significantly longer when the capsule did not reach the colon than when it did (114.9 +/- 32.6 minutes vs. 26.6 +/- 2.9 minutes; p=0.007). Small-bowel transit time also was longer. The likelihood of complete small-bowel passage was not predicted by any clinical or procedural factor. In Group 2 (metoclopramide), the capsule reached the colon in 65 (97%) patients (OR 10.3: 95% CI[2.32, 93.55], p <0.001). This improvement was associated with a significant reduction in gastric transit time (47.9 +/- 9.0 minutes vs. 30.8 +/- 7.5 minutes; p=0.025).
  
  
  CONCLUSIONS
  Metoclopramide increases the likelihood of a complete small-bowel examination in patients undergoing capsule endoscopy.
authors.affiliation: AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Warwick
authors.initials: W
authors.lastname: Selby
mesh_terms: D000368:Aged; D018492:Dopamine Antagonists / Q000008:administration & dosage*; D011211:Electric Power Supplies; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D004867:Equipment Design; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D007410:Intestinal Diseases / Q000473:pathology / Q000503:physiopathology; D007421:Intestine, Small / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage*; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D018492:Dopamine Antagonists; D008787:Metoclopramide