title: Hantaviruses: immunology, treatment, and prevention.
abstract: Hantaviruses are rodent-borne bunyaviruses that are associated with two main clinical diseases in humans: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. It has been suggested that host-related immune mechanisms rather than direct viral cytopathology may be responsible for the principal abnormality (vascular dysfunction) in these syndromes. This review summarizes the current knowledge on hantaviral host immune responses, immune abnormalities, laboratory diagnosis, and antiviral therapy as well as the current approaches in vaccine development.
authors.affiliation: Laboratory of Clinical Virology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.
authors.forename: Piet
authors.initials: P
authors.lastname: Maes
authors.forename: Jan
authors.initials: J
authors.lastname: Clement
authors.forename: Irina
authors.initials: I
authors.lastname: Gavrilovskaya
authors.forename: Marc
authors.initials: M
authors.lastname: Van Ranst
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D015195:Drug Design; D006476:Orthohantavirus / Q000145:classification / Q000276:immunology / Q000472:pathogenicity; D018778:Hantavirus Infections / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D018804:Hantavirus Pulmonary Syndrome / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D014765:Viral Vaccines
chemical_list: D000998:Antiviral Agents; D014765:Viral Vaccines