Nephrotic syndrome and angiotropic lymphoma report of a case.
A case of angiotropic lymphoma involving renal glomeruli and interstitial vessels associated with nephrotic syndrome and with minor lesions in the glomerular basal membrane is reported. A 56-year-old woman had fever, weakness and clinical findings of a nephrotic syndrome with normal renal function. Renal biopsy revealed that the glomeruli were infiltrated by neoplastic lymphoid cells positive for CD20 and CD45; the glomerular basement membranes showed a pattern of minimal change disease. This case and our review of the literature suggest that the rare association of intravascular lymphoma and glomerular disease is more than coincidental.
Cossu
Antonio
A
Azienda USL n 1 Sassari, Istituto di Anatomia ed Istologia Patologica, Sassari, Italy. cossu@uniss.it
Deiana
Angelo
A
Lissia
Amelia
A
Satta
Andrea
A
Cossu
Maria
M
Dedola
Maria Filomena
MF
Bella
Michele A
MA
Palmieri
Giuseppe
G
Tanda
Francesco
F
D018951:Antigens, CD20 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply / Q000473:pathology*; D007680:Kidney Neoplasms / Q000150:complications* / Q000473:pathology; D017493:Leukocyte Common Antigens / Q000032:analysis; D008223:Lymphoma / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000150:complications; D009404:Nephrotic Syndrome / Q000150:complications* / Q000473:pathology; D011550:Pseudomonas aeruginosa; D012772:Shock, Septic / Q000382:microbiology; D019043:Vascular Neoplasms / Q000150:complications* / Q000473:pathology
D018951:Antigens, CD20; D014408:Biomarkers, Tumor; D017493:Leukocyte Common Antigens