title: [An experimental-and-morphological substantiation of non-perforating profound sclerectomy with trabeculosuturization].
abstract: The causes of ineffectiveness of primary non-penetrating profound sclerectomy were analyzed on the basis of filtration-zone biopsy materials obtained in repeatedly made antiglaucomatous procedures. The authors believe that the above ineffectiveness is preconditioned by inconsistency of the drainage-zone internal wall resulting from its dystrophic changes due to tissue ischemia, cell apoptosis, collagen changes with fiber's degradation and fibers' colliquative necrosis. It was demonstrated experimentally that the monofilament suture, when applied to the filtration zone, enhances the hypotensive effect of the non-penetrating procedure due to the ability of filtration canals (shaping around sutures) to dose the outflow of lachrymal fluid through the anterior chamber into the subscleral and subconjunctival spaces as well as by activation of the uveoscleral outflow paths.
authors.forename: G G
authors.initials: GG
authors.lastname: Ziangirova
authors.forename: V F
authors.initials: VF
authors.lastname: Shmyreva
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Petrov
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D001706:Biopsy; D005902:Glaucoma, Open-Angle / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D011817:Rabbits; D012590:Sclera / Q000473:pathology* / Q000601:surgery; D013536:Suture Techniques; D013666:Tears / Q000502:physiology; D014130:Trabeculectomy / Q000379:methods*; D017211:Treatment Failure