title: The mammalian Mediator complex.
abstract: The multiprotein Mediator (Med) complex is an evolutionarily conserved transcriptional regulator that plays important roles in activation and repression of RNA polymerase II transcription. Prior studies identified a set of more than twenty distinct polypeptides that compose the Saccharomyces cerevisiae Mediator. Here we discuss efforts to characterize the subunit composition and associated activities of the mammalian Med complex.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, MO 64110, USA. jlc@stowers-institute.org
authors.forename: Joan Weliky
authors.initials: JW
authors.lastname: Conaway
authors.forename: Laurence
authors.initials: L
authors.lastname: Florens
authors.forename: Shigeo
authors.initials: S
authors.lastname: Sato
authors.forename: Chieri
authors.initials: C
authors.lastname: Tomomori-Sato
authors.forename: Tari J
authors.initials: TJ
authors.lastname: Parmely
authors.forename: Tingting
authors.initials: T
authors.lastname: Yao
authors.forename: Selene K
authors.initials: SK
authors.lastname: Swanson
authors.forename: Charles A S
authors.initials: CA
authors.lastname: Banks
authors.forename: Michael P
authors.initials: MP
authors.lastname: Washburn
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Conaway
mesh_terms: D000818:Animals; D008322:Mammals / Q000378:metabolism; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism; D021122:Protein Subunits; D040901:Proteomics; D015534:Trans-Activators / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D021122:Protein Subunits; D015534:Trans-Activators