title: Magnetoelastic transducers for monitoring coagulation, clot inhibition, and fibrinolysis.
abstract: Magnetoelastic transduction has been used to detect and monitor the viscosity changes that occur during the biological reactions of coagulation and fibrinolysis. Magnetoelastic sensors can be used, because the characteristic resonance frequency of the magnetoelastic strip shifts in response to the changes in fluid viscosity. At a set frequency, the output signal can be obtained over time to develop a coagulation and/or dissolution profile, which display the change in viscosity of a plasma sample that has undergone either coagulation or fibrinolysis. For coagulation screening, an exogenous tissue factor is added to an anticoagulated plasma sample to initiate coagulation. Further studies were performed to investigate fibrinolysis through the addition of plasmin. Plasmin is used in two different ways-as a competitive inhibitor before the initiation of clotting and also as a protease to dissolve the previously formed clot. This method is a viable option for the monitoring of processes that are paramount to maintaining hemostasis.
authors.affiliation: Department of Chemistry, University of Kentucky, Lexington, KY 40506-0055, USA.
authors.forename: Libby G
authors.initials: LG
authors.lastname: Puckett
authors.forename: Jaime K
authors.initials: JK
authors.lastname: Lewis
authors.forename: Aaron
authors.initials: A
authors.lastname: Urbas
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Cui
authors.forename: Dayong
authors.initials: D
authors.lastname: Gao
authors.forename: Leonidas G
authors.initials: LG
authors.lastname: Bachas
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology*; D001780:Blood Coagulation Tests / Q000379:methods; D001809:Blood Viscosity / Q000502:physiology*; D005341:Fibrinolysin; D005342:Fibrinolysis / Q000187:drug effects / Q000502:physiology*; D018056:Hemorheology / Q000379:methods; D006801:Humans; D008280:Magnetics; D013918:Thrombin Time / Q000379:methods*; D014159:Transducers; D014914:Whole Blood Coagulation Time / Q000379:methods*
chemical_list: D000925:Anticoagulants; D005341:Fibrinolysin