The correlation between thrombopoietin and platelet count in adult dengue viral infection patients.
OBJECTIVE
To investigate alteration in humoral regulation during the course of dengue viral infection.


METHODS
A prospective analytic study had been conducted involving 40 subjects with dengue viral infection. Subjects were recruited according to consecutive non-probability sampling. Subjects were categorized according to days of illness, platelet counts and serum thrombopoietin (TPO) levels. The plasma TPO levels examinations were done once daily until the platelet counts reached more than 100,000/mm(3).


RESULTS
Statistical analysis showed the mean serum TPO levels were increased during thrombocytopenia phase of the disease, and differ significantly from the convalescent phase (mean value 428 pg/ml vs 220.1 pg/ml, p= 0.00). There was also a statistically significant inverse correlation between serum TPO levels and platelet counts (p= 0.00).


CONCLUSIONS
TPO levels were significantly increased in adult patients with dengue infection in which platelets in circulation were markedly reduced, and the TPO levels were inversely related to the platelet counts.
Matondang
Asnath Vera
AV
Department of Internal Medicine, Faculty of Medicine, University of Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta.
Widodo
Djoko
D
Zulkarnain
Iskandar
I
Rengganis
Iris
I
Trihandini
Indang
I
Inada
Katsuya
K
Endo
Shigeatsu
S
D000293:Adolescent; D000328:Adult; D003715:Dengue / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D010976:Platelet Count; D011446:Prospective Studies; D013926:Thrombopoietin / Q000097:blood*
D013926:Thrombopoietin