New ways to skin a kap: mechanisms for controlling nuclear transport.
Transport between the nucleus and the cytoplasm occurs through large macromolecular assemblies called nuclear pore complexes (NPCs). The NPC is traditionally viewed as a passive structure whose primary role is to provide an interface for the soluble transport machinery, the karyopherins and their cargos, to move molecules between these compartments. Recent work has challenged this view of the NPC and provides support for a dynamic structure that can modify its architecture to actively regulate nuclear transport.
Lusk
C Patrick
CP
Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
Makhnevych
Taras
T
Wozniak
Richard W
RW
D021581:Active Transport, Cell Nucleus; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D028884:Karyopherins / Q000502:physiology; D008954:Models, Biological; D028861:Nuclear Pore Complex Proteins / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D004268:DNA-Binding Proteins; D028884:Karyopherins; D028861:Nuclear Pore Complex Proteins; C060292:PHO4 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53