Domain swapping and retroviral assembly.
The structure of a mammalian SCAN domain has been recently reported. The molecule is a structural homolog of the HIV-1 capsid protein and forms a domain-swapped dimer in solution. The authors propose a similar domain-swapping event facilitates HIV-1 assembly, providing a new model for protein-protein interactions underlying viral particle formation.
Kingston
Richard L
RL
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
Vogt
Volker M
VM
D000818:Animals; D019281:Dimerization; D015683:Gene Products, gag / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D017434:Protein Structure, Tertiary; D019065:Virus Assembly
D015683:Gene Products, gag