title: Interleukin-1 beta gene polymorphism related with allergic pathogenesis in Iris constitution.
abstract: Iridological constitution has a strong familial aggregation and is implicated in heredity. The aetiology of inflammatory bowel disease is still unknown. However, from genetic epidemiological studies there is considerable evidence that genetic factors are associated with both Crohn's disease and ulcerative colitis. We investigated the relationships between Iridological constitution and interleukin 1 beta (IL-1beta) gene polymorphism. IL-1beta is a major proinflammatiry cytokine, and the polymorphisms of this gene have been shown to be of importance in a number of diseases. Especially, IL-1 has been suspected of involvement in allergic pathogenesis. Also, IL-1beta genotype is one of the genetic markers of gastric cancer. Therefore, we classified 166 individuals according to Iris constitution, and determined IL-1beta genotype. The frequencies of Iris constitutions as follows: neurogenic type, 41 (24.7%); abdominal connective tissue weakness type, 53 (31.9%); cardio-renal connective tissue weakness type, 50 (30.1%); the others type, 22 (13.3%). Especially, the frequency of abdominal connective tissue weakness type was higher in C/T genotype than in the remaining constitutions although the statistical power was very weak. Furthermore, we first attempted to explore possible involvement of the IL-1beta polymorphism and the Iris constitution.
authors.affiliation: Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Um
authors.forename: Keum-Rok
authors.initials: KR
authors.lastname: Do
authors.forename: Woo-Jun
authors.initials: WJ
authors.lastname: Hwang
authors.forename: Tae-Yong
authors.initials: TY
authors.lastname: Shin
authors.forename: Chung-Yeon
authors.initials: CY
authors.lastname: Hwang
authors.forename: Cheorl-Ho
authors.initials: CH
authors.lastname: Kim
authors.forename: Yun-Kyung
authors.initials: YK
authors.lastname: Kim
authors.forename: Seung-Heon
authors.initials: SH
authors.lastname: Hong
authors.forename: Hyung-Min
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000529:Complementary Therapies / Q000379:methods*; D005838:Genotype; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D007375:Interleukin-1 / Q000235:genetics*; D007498:Iris / Q000473:pathology*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D007375:Interleukin-1