CD45 knockout mice, diet, and colitis: in the absence of CD45, colitis follows dietary changes.
Healthy CD45 KO mice show a Th2-type cytokine secretion profile in their small intestines. Dietary supplementation with human infant formula induced colitis and a shift toward a Th1-type profile, suggesting that diet can alter cytokine secretion.
Lópeza
María C
MC
Department of Pathology, University of Cambridge, Cambridge, CB2 1QP United Kingdom. lopezma@mail.amc.edu
Holmes
Nick
N
D000818:Animals; D003093:Colitis, Ulcerative / Q000235:genetics / Q000276:immunology*; D004032:Diet; D017353:Gene Deletion; D018928:Immunity, Mucosal / Q000235:genetics; D017493:Leukocyte Common Antigens / Q000235:genetics* / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D013601:T-Lymphocytes / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*
D017493:Leukocyte Common Antigens