title: Role of P53 and Bcl-2 in advanced rectal carcinomas treated with adjuvant therapy.
abstract: Rectal adenocarcinomas is usually associated to a poorer outcome than colon cancers. In this study we analyzed the impact on overall survival of p53 and Bcl-2, evaluated by immunohistochemical techniques, in 126 advanced rectal cancer patients submitted to 5 fluorouracil based adjuvant therapy. Shorter overall survival was observed in patients bearing p53 positive and Bcl-2 negative tumors, although in multivariate analysis only p53 emerged as independent predictor of a worse outcome. These results seem to indicate that, in stage III-IV rectal cancer, p53 alterations may identify high risk patients to be enrolled in more aggressive and/or innovative adjuvant/neoadjuvant treatments.
authors.affiliation: Department of Pathology, Regina Elena Cancer Institute Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Piperno
authors.forename: M
authors.initials: M
authors.lastname: Cosimelli
authors.forename: Donnorso R
authors.initials: DR
authors.lastname: Perrone
authors.forename: R
authors.initials: R
authors.lastname: Mancini
authors.forename: S
authors.initials: S
authors.lastname: Buglioni
authors.forename: F
authors.initials: F
authors.lastname: Novelli
authors.forename: I
authors.initials: I
authors.lastname: Sperduti
authors.forename: V
authors.initials: V
authors.lastname: Zerbini
authors.forename: C
authors.initials: C
authors.lastname: Garufi
authors.forename: M
authors.initials: M
authors.lastname: Mottolese
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis*; D012004:Rectal Neoplasms / Q000737:chemistry / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53