Prenylbicyclogermacrane diterpenoids from the formosan soft coral Nephthea pacifica.
Ten new prenylbicyclogermacrane diterpenoids, pacificins A-J (1-10), were isolated from the methylene chloride solubles of the Formosan soft coral Nephthea pacifica. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
El-Gamal
Ali A H
AA
Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
Wang
Shang-Kwei
SK
Dai
Chang-Feng
CF
Chen
I-Gin
IG
Duh
Chang-Yih
CY
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013624:Taiwan
D000970:Antineoplastic Agents; D004224:Diterpenes