title: Lack of evidence for genetic association to RUNX1 binding site at PSORS2 in different German psoriasis cohorts.
abstract: A DNA variant, rs734232, altering a RUNX1 binding site was recently reported as susceptibility allele at PSORS2 (17q25) in cohorts of psoriasis patients from the US. A testing of this variant in psoriasis patients from Germany did not confirm this association in 300 trios nor in two case-control studies with 281 patients with psoriasis vulgaris and 375 patients with psoriatic arthritis, respectively. These results fail to support rs734232 as a psoriasis susceptibility factor in German psoriasis patients.
authors.affiliation: Institute of Human Genetics, University Erlangen-Nuremberg, Nuremberg, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Hüffmeier
authors.forename: Heiko
authors.initials: H
authors.lastname: Traupe
authors.forename: Harald
authors.initials: H
authors.lastname: Burkhardt
authors.forename: Funda
authors.initials: F
authors.lastname: Schürmeier-Horst
authors.forename: Jesus
authors.initials: J
authors.lastname: Lascorz
authors.forename: Beate
authors.initials: B
authors.lastname: Böhm
authors.forename: Jörg
authors.initials: J
authors.lastname: Lohmann
authors.forename: Markward
authors.initials: M
authors.lastname: Ständer
authors.forename: Jörg
authors.initials: J
authors.lastname: Wendler
authors.forename: Reinhard
authors.initials: R
authors.lastname: Kelsch
authors.forename: Claudia
authors.initials: C
authors.lastname: Baumann
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Küster
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Wienker
authors.forename: André
authors.initials: A
authors.lastname: Reis
mesh_terms: D000293:Adolescent; D000328:Adult; D015535:Arthritis, Psoriatic / Q000453:epidemiology / Q000235:genetics*; D001665:Binding Sites / Q000235:genetics; D016022:Case-Control Studies; D002886:Chromosomes, Human, Pair 17; D002896:Chromosomes, Human, Pair 6; D015331:Cohort Studies; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C493728:RUNX1 protein, human; D014157:Transcription Factors