Interaction of modified cyclodextrins with cytochrome P-450.
The effects of modified cyclodextrins (CDs) hydroxypropyl-beta-CD and methyl-beta-CD were studied in vitro on cDNA-expressed human cytochrome P-450 (CYP) activities (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4). The modified CDs inhibited the activities of CYP2C19 and CYP3A4 while enhancing CYP2C9 activity by 140 to 176% relative to the control values at lower concentrations. In addition, methyl-beta-CD inhibited CYP1A2 and CYP2D6 at higher concentrations.
Ishikawa
Minoru
M
Department of Biotechnology, Faculty of Engineering, Tottori University, Tottori, Japan.
Yoshii
Hidefumi
H
Furuta
Takeshi
T
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology; D047392:beta-Cyclodextrins / Q000737:chemistry / Q000378:metabolism*
D047392:beta-Cyclodextrins; C108732:methyl-beta-cyclodextrin; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D003577:Cytochrome P-450 Enzyme System