title: Influenza-associated encephalopathy: no evidence for neuroinvasion by influenza virus nor for reactivation of human herpesvirus 6 or 7.
abstract: During 2 consecutive influenza seasons we investigated the presence of influenza virus, human herpesvirus (HHV) type 6, and HHV-7 in cerebrospinal fluid samples from 9 white children suffering from influenza-associated encephalopathy. We conclude that it is unlikely that neuroinvasion by influenza virus or reactivation of either HHV-6 or HHV-7 is involved.
authors.affiliation: Department of Medical Microbiology, Public Health Laboratory Friesland, Leeuwarden, The Netherlands. jan.van.zeijl@lvf.nl
authors.forename: J H
authors.initials: JH
authors.lastname: van Zeijl
authors.forename: J
authors.initials: J
authors.lastname: Bakkers
authors.forename: B
authors.initials: B
authors.lastname: Wilbrink
authors.forename: W J G
authors.initials: WJ
authors.lastname: Melchers
authors.forename: R A
authors.initials: RA
authors.lastname: Mullaart
authors.forename: J M D
authors.initials: JM
authors.lastname: Galama
mesh_terms: D001927:Brain Diseases / Q000209:etiology / Q000821:virology*; D002675:Child, Preschool; D015654:Herpesvirus 6, Human / Q000502:physiology*; D016199:Herpesvirus 7, Human / Q000502:physiology*; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000150:complications*; D009975:Orthomyxoviridae / Q000502:physiology*; D019349:Roseolovirus Infections / Q000150:complications; D014775:Virus Activation