title: Idiopathic necrotizing dermatitis: current management.
abstract: OBJECTIVE
  To identify and demonstrate necrotizing dermatitis in infancy; an uncommon, puzzling syndrome, in which anecdotal reporting and personal experience indicates that one third of cases may require skin grafting. Much informed discussion about the pathogenesis of this distressing syndrome centres on the role of spider envenomation; and in particular on the speculative role of the Australian White-tailed spider, Lampona cylindrata.
  
  
  METHODS
  We present here six cases of necrotizing dermatitis treated surgically at the Royal Children's Hospital and Mater Children's Hospital in Brisbane over the period from 1991 to 1999. Clinical history, surgical details and pathological investigations were reviewed in each case. Microbiological investigation of necrotic ulcers included standard aerobic and anaerobic culture.
  
  
  RESULTS
  Nocardia and Staphylococcus were cultured in two cases, but no positive bites were witnessed and no spiders were identified by either the children or their parents. All cases were treated with silver sulphadiazine creme. Two of the infants required general anaesthesia, excision debridement and split skin grafting. The White-tailed spider, Lampona cylindrata, does not occur in Queensland, but Lampona murina does; neither species has necrotizing components in its venom. Circumstantial evidence is consistent with this syndrome being due to invertebrate envenomation, possibly following arachnid bites.
  
  
  CONCLUSIONS
  In our experience there is insufficient evidence to impute a specific genus as the cause, at this stage of scientific knowledge. If the offending creature is a spider, we calculate that the syndrome of necrotizing dermatitis occurs in less than 1 in 5000 spider bites.
authors.affiliation: Department of Paediatric Surgery, Royal Children's Hospital, Brisbane, Queensland, Australia.
authors.forename: P C
authors.initials: PC
authors.lastname: Lui
authors.forename: D
authors.initials: D
authors.lastname: Petersen
authors.forename: R M
authors.initials: RM
authors.lastname: Kimble
authors.forename: R J
authors.initials: RJ
authors.lastname: Raven
authors.forename: J H
authors.initials: JH
authors.lastname: Pearn
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001733:Bites and Stings / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D002675:Child, Preschool; D003872:Dermatitis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009336:Necrosis; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D012883:Skin Ulcer / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D001098:Spider Bites / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013112:Spiders
chemical_list: D000891:Anti-Infective Agents, Local; D012837:Silver Sulfadiazine