Ultrastructure of internal limiting membrane in myopic foveoschisis.
OBJECTIVE
To reveal the pathogenesis of myopic foveoschisis (MF).


METHODS
Clinicopathological report.


METHODS
Internal limiting membranes (ILMs) were collected from ten patients with MF and five patients with idiopathic macular hole (IMH) as a control. Samples were subjected to transmission electron microscopic study. Characteristics of the ILM were compared between the two groups.


RESULTS
Collagen fiber and cell debris were identified on the inner surface of ILM in seven eyes (70%) with MF, significantly more (P < .05) than found in IMH subjects (0%). More fibrous glial cells were likely to be found on the inner surface of ILM. No significant difference in fibroblast-like cell adhesion was observed.


CONCLUSIONS
Collagen fiber and cellular component are suggested to play an important role in developing MF. ILM peeling may be essential for vitrectomy for MF.
Bando
Hajime
H
Department of Ophthalmology, Graduate School of Medicine, Osaka University, Osaka, Japan. bando@ophthal.med.osaka-u.ac.jp
Ikuno
Yasushi
Y
Choi
Jun-Sub
JS
Tano
Yasuo
Y
Yamanaka
Ichiro
I
Ishibashi
Tatsuro
T
D000368:Aged; D001485:Basement Membrane / Q000648:ultrastructure; D003094:Collagen / Q000648:ultrastructure; D019773:Epiretinal Membrane / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009216:Myopia / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D009457:Neuroglia / Q000648:ultrastructure; D012167:Retinal Perforations / Q000473:pathology / Q000601:surgery; D041441:Retinoschisis / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D014821:Vitrectomy
D003094:Collagen