The presentation of haptenated proteins and activation of T cells in the mesenteric lymph nodes by dendritic cells in the TNBS colitis rat.
We described the role of dendritic cells (DCs) in aspects of T cell activation at the mesenteric lymph nodes (MLN) in trinitrobenzene sulfonic acid (TNBS)-induced colitis. An antigenic-immune response is induced at the MLN, and dendritic cells are the affected cell type. Cross-linking and GRO/CINC-1 have synergistic effects for DC maturation.
Ishiguro
Yoh
Y
First Department of Internal medicine, Hirosaki University School of Medicine, 5 zaifu-cho, Hirosaki, Japan. yishi-hki@umin.ac.jp
Sakuraba
Hirotake
H
Yamagata
Kazufumi
K
Munakata
Akihiro
A
D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D004195:Disease Models, Animal; D006241:Haptens / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology*; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology*; D014302:Trinitrobenzenesulfonic Acid
D006241:Haptens; D014302:Trinitrobenzenesulfonic Acid