title: Impact of the presence of one or more multinucleated blastomeres on the developmental potential of the embryo to the blastocyst stage.
abstract: A retrospective study of 5,982 embryos in 619 blastocyst-stage embryo transfer cycles revealed that detection of multinucleated blastomeres either on day 2 or 3 signifies a poor prognosis for blastocyst formation and that no good-quality blastocyst can be expected from an embryo with more than one multinucleated blastomere. Patients should be counseled regarding a poor prognosis when multiple embryos with multinucleated blastomeres are present.
authors.affiliation: Assisted Reproduction Unit, American Hospital of Istanbul, Istanbul, Turkey. kayhany@amerikanhastanesi.com.tr
authors.forename: Kayhan
authors.initials: K
authors.lastname: Yakin
authors.forename: Basak
authors.initials: B
authors.lastname: Balaban
authors.forename: Bulent
authors.initials: B
authors.lastname: Urman
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000502:physiology*; D001757:Blastomeres / Q000502:physiology* / Q000648:ultrastructure*; D002467:Cell Nucleus / Q000648:ultrastructure*; D047108:Embryonic Development; D005260:Female; D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies