title: A prospective multicenter study to evaluate the feasibility and safety of aggressive antihypertensive treatment in patients with acute intracerebral hemorrhage.
abstract: The authors performed a multicenter prospective observational study to evaluate the feasibility and safety of intravenous antihypertensive protocol for acute hypertension in patients with intracerebral hemorrhage (ICH). Twenty-seven patients with ICH and acute hypertension (mean age 61.37 +/- 14.27; 10 were men) were treated to maintain the systolic blood pressure (BP) below 160 mm Hg and diastolic BP below 90 mm Hg within 24 hours of symptom onset. Neurological deterioration (defined as a decrease in initial Glasgow Coma Scale score > or = 2) was observed in 2 (7.4%) of 27 patients during treatment. Among patients who underwent follow-up computed tomography, hematoma expansion (more than 33% increase in hematoma size at 24 hours) was observed in 2 (9.1%) of 22 patients. Patients treated within 6 hours of symptom onset were more likely to be functionally independent (modified Rankin scale < or = 2) at 1 month compared with patients who were treated between 6 and 24 hours (8 of 18 versus 0 of 9,P = .03). Aggressive pharmacological treatment of acute hypertension in patients with ICH can be initiated early with a low rate of neurological deterioration and hematoma expansion.
authors.affiliation: Zennat Qureshi Stroke Research Center, Department of Neurology and Neurosciences, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103-2425, USA. aiqureshi@hotmail.com
authors.forename: Adnan I
authors.initials: AI
authors.lastname: Qureshi
authors.forename: Yousef M
authors.initials: YM
authors.lastname: Mohammad
authors.forename: Abutaher M
authors.initials: AM
authors.lastname: Yahia
authors.forename: Jose I
authors.initials: JI
authors.lastname: Suarez
authors.forename: Amir M
authors.initials: AM
authors.lastname: Siddiqui
authors.forename: Jawad F
authors.initials: JF
authors.lastname: Kirmani
authors.forename: M Fareed K
authors.initials: MF
authors.lastname: Suri
authors.forename: James
authors.initials: J
authors.lastname: Kolb
authors.forename: Osama O
authors.initials: OO
authors.lastname: Zaidat
mesh_terms: D000208:Acute Disease; D000465:Algorithms; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D000959:Antihypertensive Agents