CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia.
The Nogo gene was putatively implicated in schizophrenia based on gene expression and genetic association data. In this study, we attempt to replicate the possible association of the CAA insertion and a nearby TATC deletion with schizophrenia in 204 complete and incomplete triads and in a sample of 462 unrelated cases and 153 controls, all of Caucasian origin. Our genotyping results indicated that neither the trinucleotide insertion polymorphism (CAAins; 43.4% vs. 41.8%, p>0.5) nor the polymorphism-TATC deletion (TATCdel; 49.8% vs. 49.3%, p>0.1) allele frequency is significantly different in patients compared to controls. The homozygous CAAins frequency is not significantly different between patients and controls either (18.0% vs. 15.0%, chi2=0.985, p>0.1). Furthermore, neither CAAins/TATCdel individually, nor the haplotype carrying both CAAins and TATCdel is preferentially transmitted to affected offspring.
Xiong
Lan
L
Department of Psychiatry, Douglas Hospital Research Centre, 6875 Boulevard Lasalle, FBC Pavillion, Verdun, Quebec, Canada H4H1R3.
Rouleau
Guy A
GA
Delisi
Lynn E
LE
St-Onge
Judith
J
Najafee
Robert
R
Rivière
Jean-Baptiste
JB
Benkelfat
Chawki
C
Tabbane
Karim
K
Fathalli
Ferid
F
Danics
Zoltan
Z
Labelle
Alain
A
Lal
Samarthji
S
Joober
Ridha
R
D020413:3' Untranslated Regions; D016009:Chi-Square Distribution; D002889:Chromosomes, Human, Pair 2; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008609:Mental Status Schedule; D008967:Molecular Biology / Q000379:methods; D009185:Myelin Proteins / Q000235:genetics*; D000070798:Nogo Proteins; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*; D044465:White People
D020413:3' Untranslated Regions; D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human