title: Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice.
abstract: The present study evaluated the neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rodents. Effects on the spontaneous motor activity (SMA), exploratory behaviour, pentobarbital sleeping time, apomorphine-induced stereotypic behaviour and motor coordination (rota-rod performance) were investigated. The extract (50-200 mg/kg p.o.) significantly (P<0.05) decreased the SMA and exploratory behaviour in mice and prolonged pentobarbital sleeping time in rats dose-dependently. The extract also remarkably attenuated the intensity of apomorphine-induced stereotypy dose-dependently in mice, but had no effect on motor coordination as determined by the performance on rota-rod. These results indicate the presence of psychoactive substances in the aqueous extract of the root bark of Nauclea latifolia.
authors.affiliation: Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P. M. B. 21, Garki, Abuja, Nigeria. samsonamos@yahoo.co.uk
authors.forename: S
authors.initials: S
authors.lastname: Amos
authors.forename: J
authors.initials: J
authors.lastname: Abbah
authors.forename: B
authors.initials: B
authors.lastname: Chindo
authors.forename: I
authors.initials: I
authors.lastname: Edmond
authors.forename: L
authors.initials: L
authors.lastname: Binda
authors.forename: B
authors.initials: B
authors.lastname: Adzu
authors.forename: S
authors.initials: S
authors.lastname: Buhari
authors.forename: A A
authors.initials: AA
authors.lastname: Odutola
authors.forename: C
authors.initials: C
authors.lastname: Wambebe
authors.forename: K
authors.initials: K
authors.lastname: Gamaniel
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D019666:Rubiaceae; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology; D014867:Water / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D014867:Water