Pyroglutamyl-asparagine amide normalizes long-term potentiation in rat hippocampal slices.
Preapplication of peptide piracetam analogue pyroglutamyl-asparagine amide to rat hippocampal slices facilitates long-term potentiation of focal responses in the CA1 field after weak tetanization of the synaptic input (30 pulses, 100 Hz). This treatment normalized the development of long-term potentiation after standard tetanization (100 pulses, 100 Hz) impaired by ethanol.
Kapai
N A
NA
Institute of Brain Research, Russian Academy of Medical Sciences, Moscow.
Chepkova
A N
AN
Gudasheva
T A
TA
Morozova
A A
AA
Skrebitskii
V G
VG
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology*; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D004151:Dipeptides; D018697:Nootropic Agents; D010446:Peptide Fragments; C081772:pyroglutamyl-asparaginamide; D001127:Arginine Vasopressin; C045881:argipressin (4-9); D011761:Pyrrolidonecarboxylic Acid