title: Radiologic findings in patients treated with boron neutron capture therapy for glioblastoma multiforme within EORTC trial 11961.
abstract: OBJECTIVE
  To assess the occurrence and development of cerebral radiologic changes (cerebral atrophy and white matter lesions) in patients treated with boron neutron capture therapy (BNCT) for primary supratentorial glioblastoma multiforme within the European Organization for Research and Treatment of Cancer (EORTC) trial 11961.
  
  
  METHODS
  Magnetic resonance imaging (MRI) scans were performed before and after surgery and at 1 week and 2, 4.5, 6, 9, 12, 15, and 18 months after BNCT. For the current study, MRI scans of all assessable patients were analyzed, with emphasis on cerebral atrophy and white matter abnormalities.
  
  
  RESULTS
  Twenty-six patients had been treated with BNCT according to the EORTC trial 11961, of whom 24 were assessable for the current study. The development of possible BNCT-related cerebral changes was observed in 12 patients (50%), 10 of whom had cerebral atrophy (42%) and 10 white matter changes (42%) after a median interval of 7.5 and 4.5 months, respectively.
  
  
  CONCLUSIONS
  In this study, cerebral radiologic changes appeared in 50% of patients within the first year after BNCT. Although a clear correlation between the BNCT dose and the development of cerebral changes could not be demonstrated, a relationship between the occurrence of these radiologic abnormalities and BNCT seems likely.
authors.affiliation: Department of Neurology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands. mj.vos@vumc.nl
authors.forename: Maaike J
authors.initials: MJ
authors.lastname: Vos
authors.forename: Bernd
authors.initials: B
authors.lastname: Turowski
authors.forename: Friedhelm E
authors.initials: FE
authors.lastname: Zanella
authors.forename: Philippe
authors.initials: P
authors.lastname: Paquis
authors.forename: Axel
authors.initials: A
authors.lastname: Siefert
authors.forename: Katalin
authors.initials: K
authors.lastname: Hideghéty
authors.forename: Klaus
authors.initials: K
authors.lastname: Haselsberger
authors.forename: Frank
authors.initials: F
authors.lastname: Grochulla
authors.forename: Tjeerd J
authors.initials: TJ
authors.lastname: Postma
authors.forename: Andrea
authors.initials: A
authors.lastname: Wittig
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Heimans
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Slotman
authors.forename: W Peter
authors.initials: WP
authors.lastname: Vandertop
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sauerwein
mesh_terms: D000368:Aged; D001284:Atrophy / Q000209:etiology / Q000473:pathology; D016754:Boron Neutron Capture Therapy / Q000009:adverse effects*; D001921:Brain / Q000473:pathology / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D005260:Female; D005909:Glioblastoma / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies