The diastereoselective synthesis of quaternary substituted thioindolines from sulfur ylide intermediates.
The Rh(II)-catalyzed coupling of chiral 2-thiopyranylindoles with vinyl diazoacetates results in the generation of indolines having quaternary substitution at C3 in high diastereoselectivity.
Nyong
Abijah M
AM
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
Rainier
Jon D
JD
D001372:Aza Compounds / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism; D013457:Sulfur Compounds / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry
D001372:Aza Compounds; D007211:Indoles; D013457:Sulfur Compounds; D014753:Vinyl Compounds; C057812:indoline; D012238:Rhodium