title: Editorial overview: from Vioxx to Luckenbach: drug discovery at a crossroads.
authors.forename: Mike
authors.initials: M
authors.lastname: Williams
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards; D017277:Drug Approval; D015195:Drug Design; D004345:Drug Industry; D007783:Lactones / Q000009:adverse effects*; D013450:Sulfones / Q000009:adverse effects*
chemical_list: D007783:Lactones; D013450:Sulfones; C116926:rofecoxib