Effects of dietary protein of Korean foxtail millet on plasma adiponectin, HDL-cholesterol, and insulin levels in genetically type 2 diabetic mice.
We examined the effects of intake of Korean foxtail millet protein (FMP) on plasma levels of lipid, glucose, insulin, and adiponectin in genetically type 2 diabetic KK-Ay mice. When mice were fed a normal FMP diet or a high-fat-high-sucrose diet containing FMP for 3 weeks, in both experiments plasma concentrations of high-density lipoprotein cholesterol (HDL-cholesterol) and adiponectin increased remarkably in comparison with a casein diet group, whereas concentrations of insulin decreased greatly and that of plasma glucose was comparable to that in the casein diet group. Considering the role of adiponectin, insulin, and HDL-cholesterol in diabetes, atherosclerosis, and obesity, it appears likely that FMP may improve insulin sensitivity and cholesterol metabolism through an increase in adiponectin concentration. Therefore, FMP would serve as another beneficial food component in obesity-related diseases such as type 2 diabetes and cardiovascular diseases.
Choi
You-Young
YY
United Graduate School of Agricultural Sciences, Iwate University, Iwate, Japan.
Osada
Kyoichi
K
Ito
Yoshiaki
Y
Nagasawa
Takashi
T
Choi
Myeong-Rak
MR
Nishizawa
Naoyuki
N
D052242:Adiponectin; D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000178:diet therapy; D004044:Dietary Proteins / Q000032:analysis / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects; D005247:Feeding Behavior; D007328:Insulin / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D032983:Setaria Plant / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
D052242:Adiponectin; D001786:Blood Glucose; D008076:Cholesterol, HDL; D004044:Dietary Proteins; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol