title: Effects of phenolic acid esters and amides on stimulus-induced reactive oxygen species production in human neutrophils.
abstract: BACKGROUND
  Phenolic acids and their derivatives are widely distributed in plants. A series of phenolic acid esters and amides have been synthesized.
  
  
  METHODS
  We determined the effects of phenolic acid derivatives on antiinflammatory activity against phorbol 12-myristate 13-acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced production of superoxide anion, an inflammatory mediator produced by neutrophils.
  
  
  RESULTS
  When the cells were preincubated with phenolic acids and their derivatives, the superoxide generation induced by fMLP (1.0 micromol/l) and PMA (0.16 micromol/l) was inhibited to various degrees with compounds 1, 2 and 4 significantly suppressing such generation in a concentration-dependent manner.
  
  
  CONCLUSIONS
  Phenolic acid derivatives may exert their antiinflammatory action through inhibiting superoxide generation.
authors.affiliation: Department of Pharmacology, National Yang-Ming University, No. 155, Sec 2, Shih-Pai, Li-Nung Street, Peitou, Taipei 112, Taiwan, ROC.
authors.forename: Ya-Ting
authors.initials: YT
authors.lastname: Lee
authors.forename: Ming-Jaw
authors.initials: MJ
authors.lastname: Don
authors.forename: Chang-Hui
authors.initials: CH
authors.lastname: Liao
authors.forename: Hua-Wen
authors.initials: HW
authors.lastname: Chiou
authors.forename: Chieh-Fu
authors.initials: CF
authors.lastname: Chen
authors.forename: Li-Kang
authors.initials: LK
authors.lastname: Ho
mesh_terms: D000577:Amides / Q000494:pharmacology*; D004952:Esters; D006801:Humans; D062385:Hydroxybenzoates / Q000494:pharmacology*; D018836:Inflammation Mediators / Q000097:blood* / Q000502:physiology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000097:blood*; D013481:Superoxides / Q000097:blood
chemical_list: D000577:Amides; D004952:Esters; D062385:Hydroxybenzoates; D018836:Inflammation Mediators; D017382:Reactive Oxygen Species; D013481:Superoxides; C017616:phenolic acid