Histidine increases beta-adrenoreactivity of myocardium in frogs.
Histidine (3x10(-5) g/ml) had no effect on contractility and chronoinotropic relationships in frog myocardium, but rapidly and reversibly increased myocardial beta-adrenoreactivity (increased myocardial response to 7x10(-8), 3x10(-7), and 4x10(-6) g/ml epinephrine) and potentiated the positive effect of epinephrine (7x10(-8), 3x10(-7) g/ml) on chronoinotropic relationships in the myocardium. Histidine is considered to be a component of endogenous sensitizer of beta-adrenoceptors in human blood modulating the function of cardiomyocytes.
Trukhin
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Department of Anatomy, Physiology, and Valeology, Vyatka State Humanitarian University.
Tsirkin
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VI
Sizova
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D000818:Animals; D004357:Drug Synergism; D004837:Epinephrine / Q000494:pharmacology; D006321:Heart / Q000187:drug effects* / Q000502:physiology*; D006639:Histidine / Q000494:pharmacology*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D011895:Rana ridibunda; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D013268:Stimulation, Chemical
D011943:Receptors, Adrenergic, beta; D006639:Histidine; D004837:Epinephrine