title: Oophorectomy during surgery for colorectal carcinoma.
abstract: BACKGROUND
  The purpose of the study is to identify the effect of synchronous prophylactic oophorectomy in women undergoing colorectal cancer surgery on long-term survival, recurrences and sites of failure.
  
  
  METHODS
  From 1987 to 2003, 124 women, mean age 69+/-10 (35-91) years, with colorectal carcinoma were retrospectively reviewed. In 70 (56.5%) women the ovaries were preserved during surgery and 54 (43.5%) women underwent synchronous prophylactic oophorectomy during primary tumour resection. Univariate and multivariate analysis were used to assess the effect of oophorectomy on long-term survival, recurrences and sites of failure.
  
  
  RESULTS
  By univariate analysis it was demonstrated that synchronous oophorectomy had no effect on long-term survival (p=0.7294). By multivariate analysis it was demonstrated that stage was the only factor independently influencing survival (p=0.0061). Twenty-eight patients (23%) developed recurrence and 10 of them developed locoregional recurrence. By univariate analysis it was demonstrated that the number of recurrences was not different between women with or without oophorectomy (p=0.259). Distant and locoregional recurrences were not different between women undergoing resection of primary colorectal carcinoma with or without oophorectomy (p=0.611).
  
  
  CONCLUSIONS
  Oophorectomy does not appear to influence long-term survival, the total number of recurrences or the sites of failure.
authors.affiliation: Surgical Department, Didimotichon General Hospital, Didimotichon 68300, Greece. antonios_tentes@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Tentes
authors.forename: S
authors.initials: S
authors.lastname: Markakidis
authors.forename: C
authors.initials: C
authors.lastname: Mirelis
authors.forename: C
authors.initials: C
authors.lastname: Leventis
authors.forename: K
authors.initials: K
authors.lastname: Mitrousi
authors.forename: A
authors.initials: A
authors.lastname: Gosev
authors.forename: C
authors.initials: C
authors.lastname: Kaisas
authors.forename: Y
authors.initials: Y
authors.lastname: Bouyioukas
authors.forename: A
authors.initials: A
authors.lastname: Xanthoulis
authors.forename: O
authors.initials: O
authors.lastname: Korakianitis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003082:Colectomy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D010052:Ovariectomy / Q000379:methods*; D011336:Probability; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome