Variability in fMRI: a re-examination of inter-session differences.
We revisit a previous study on inter-session variability (McGonigle et al. [2000]: Neuroimage 11:708-734), showing that contrary to one popular interpretation of the original article, inter-session variability is not necessarily high. We also highlight how evaluating variability based on thresholded single-session images alone can be misleading. Finally, we show that the use of different first-level preprocessing, time-series statistics, and registration analysis methodologies can give significantly different inter-session analysis results.
Smith
Stephen M
SM
Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Department of Clinical Neurology, Oxford University, John Radcliffe Hospital, Headington, Oxford, United Kingdom. steve@fmrib.ox.ac.uk
Beckmann
Christian F
CF
Ramnani
Narender
N
Woolrich
Mark W
MW
Bannister
Peter R
PR
Jenkinson
Mark
M
Matthews
Paul M
PM
McGonigle
David J
DJ
D000328:Adult; D016477:Artifacts; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D019416:Head Movements; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D015203:Reproducibility of Results