Anti-annexin V antibodies: are they prothrombotic?
Annexin V inhibits prothrombin activation and is able to prevent thrombus formation under normal venous and arterial blood flow conditions. Antibodies to annexin V have been identified in association with several pathological conditions, including systemic lupus erythematosus (SLE) with or without anti-phospholipid syndrome, recurrent spontaneous abortions and systemic sclerosis (SSc). These antibodies are suspected to exert a detrimental role and interfere with annexin V function. Thus, they have been associated with the occurrence of foetal loss and venous and/or arterial thrombosis in SLE patients, as well as digital ischemia in SSc patients. However, their true pathogenic role remains to be proven.
Esposito
Gaëtan
G
UPRES EA 1833, Laboratoire d'Immunologie, Pavillon Gustave Roussy, 4e etage, UFR Cochin Port-Royal, 8 rue Mechain, Université Paris V, Paris 75014, France.
Tamby
Mathieu C
MC
Chanseaud
Youri
Y
Servettaz
Amélie
A
Guillevin
Loïc
L
Mouthon
Luc
L
D000026:Abortion, Habitual / Q000276:immunology; D017304:Annexin A5 / Q000276:immunology*; D000906:Antibodies / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D012595:Scleroderma, Systemic / Q000276:immunology; D013927:Thrombosis / Q000276:immunology*
D017304:Annexin A5; D000906:Antibodies