title: Event-related potential correlates selectively reflect cognitive dysfunction in schizophrenics.
abstract: Schizophrenics show event-related potential (ERP) and particularly P3 abnormalities. To study the more detailed relationships between these ERP alterations and cognitive dysfunction we recorded and analyzed ERPs using a particular experimental approach. In 34 schizophrenics and 25 controls ERPs were obtained by a visual Go/Nogo task requiring response inhibition and were decomposed into temporally independent topographical components using Independent Component Analysis (ICA). ICA disentangled different subcomponents of P3. Subcomponent P3b with a parietal maximum amplitude was significantly reduced in the schizophrenics, probably reflecting their attentional deficits. Subcomponent P3ng with a frontal maximum amplitude and enhanced during Nogo condition appeared as an electrophysiological index of response inhibition. A significantly reduced P3ng enhancement, found in schizophrenics, probably reflects their impaired response control.
  
  
  CONCLUSIONS
  ICA can successfully identify ERP subcomponents with distinct scalp topographies representing significant differential indices of normal and abnormal cognitive processing. Involvement of frontal brain areas in disturbed executive control in schizophrenics is supported by our ICA findings.
authors.affiliation: Department of Psychiatry and Psychotherapy, Albert-Ludwigs-University, Freiburg, Germany. hans_olbrich@psyallg.ukl.uni-freiburg.de
authors.forename: H M
authors.initials: HM
authors.lastname: Olbrich
authors.forename: H
authors.initials: H
authors.lastname: Maes
authors.forename: G
authors.initials: G
authors.lastname: Valerius
authors.forename: J M
authors.initials: JM
authors.lastname: Langosch
authors.forename: B
authors.initials: B
authors.lastname: Feige
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*