Ratio between the contents of 11-dehydrocorticosterone and corticosterone after acute and repeated stress: effect of dehydroepiandrosterone sulfate.
Acute stress was accompanied by reduction of 11-dehydrocorticosterone to corticosterone in male rats. The reverse reaction predominated during repeated stress and increased after administration of dehydroepiandrosterone sulfate. Treatment with mu-opioid receptor antagonist naltrexone in a dose of 0.1 mg/kg 20 min before administration of dehydroepiandrosterone sulfate abolished this effect.
Obut
T A
TA
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. t.a.obut@ iph.ma.nsc.ru
Ovsyukova
M V
MV
Cherkasova
O P
OP
D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000378:metabolism; D000818:Animals; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000097:blood*; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D008297:Male; D009271:Naltrexone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000187:drug effects; D013312:Stress, Physiological / Q000378:metabolism*
D017450:Receptors, Opioid, mu; D019314:Dehydroepiandrosterone Sulfate; D009271:Naltrexone; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; C003552:11-dehydrocorticosterone; D003345:Corticosterone