Toward establishing a therapeutic window for rTMS by theta burst stimulation.
In this issue of Neuron, Huang et al. show that a version of the classic theta burst stimulation protocol used to induce LTP/LTD in brain slices can be adapted to a transcranial magnetic stimulation (TMS) protocol to rapidly produce long lasting (up to an hour), reversible effects on motor cortex physiology and behavior. These results may have important implications for the development of clinical applications of rTMS in the treatment of depression, epilepsy, Parkinson's, and other diseases.
Paulus
Walter
W
Department of Clinical Neurophysiology, University of Goettingen, D-37075 Goettingen, Germany.
D000818:Animals; D003863:Depression / Q000628:therapy; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000379:methods*; D004827:Epilepsy / Q000628:therapy; D006801:Humans; D008280:Magnetics / Q000009:adverse effects / Q000627:therapeutic use*; D009044:Motor Cortex / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D013826:Theta Rhythm / Q000379:methods*; D013997:Time Factors