title: The association of body mass index and prostate-specific antigen in a population-based study.
abstract: BACKGROUND
  Recent studies of men with prostate carcinoma suggest that obesity may be associated with more advanced-stage disease and lower overall survival rates. One possible link between body mass index (BMI) and prostate carcinoma prognosis may be disease ascertainment. Prostate-specific antigen (PSA) is widely used to screen for prostate carcinoma.
  
  
  METHODS
  The authors examined the association between BMI and PSA in a population-based study of 2779 men without prostate carcinoma. Between 2001 and 2004, these men were enrolled in a study sponsored by the San Antonio Center of Biomarkers of Risk, a clinical and epidemiologic center of the Early Detection Research Network of the National Cancer Institute.
  
  
  RESULTS
  The mean PSA value decreased in a linear fashion with an increase in BMI category, from 1.01 ng/mL in normal weight men to 0.69 ng/mL in obese (Class III) men, after adjusting for race/ethnicity and age.
  
  
  CONCLUSIONS
  Lower levels of PSA in obese and overweight men could mask biologically consequential prostate carcinoma.
authors.affiliation: Center for Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, Texas 78284-7802, USA. baillargeon@uthscsa.edu
authors.forename: Jacques
authors.initials: J
authors.lastname: Baillargeon
authors.forename: Brad H
authors.initials: BH
authors.lastname: Pollock
authors.forename: Alan R
authors.initials: AR
authors.lastname: Kristal
authors.forename: Patrick
authors.initials: P
authors.lastname: Bradshaw
authors.forename: Javier
authors.initials: J
authors.lastname: Hernandez
authors.forename: Joseph
authors.initials: J
authors.lastname: Basler
authors.forename: Betsy
authors.initials: B
authors.lastname: Higgins
authors.forename: Steve
authors.initials: S
authors.lastname: Lynch
authors.forename: Thomas
authors.initials: T
authors.lastname: Rozanski
authors.forename: Dean
authors.initials: D
authors.lastname: Troyer
authors.forename: Ian
authors.initials: I
authors.lastname: Thompson
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis*
chemical_list: D017430:Prostate-Specific Antigen