title: Pseudosarcomatous fibrovascular proliferative tissue masquerading as a primary subglottic angiosarcoma.
abstract: A unique case of pseudosarcomatous fibrovascular proliferative tissue causing biphasic stridor and simulating a primary subglottic angiosarcoma is reported. The patient presented with a wheeze and was diagnosed initially with asthma. He subsequently developed worsening biphasic stridor. Flexible nasendoscopy revealed a subglottic mass obstructing the airway. The mass was removed with a carbon dioxide laser and the patient's condition improved dramatically. The specimen was difficult to interpret histologically and was thought at first to be a novel case of a primary subglottic angiosarcoma. However, the slides were reviewed by expert soft tissue pathologists in the UK and USA, and a final diagnosis of a pseudosarcomatous fibrovascular proliferative lesion was made. This case highlights the important principle of seeking additional opinions before making a malignant diagnosis in an atypical site. Our report also emphasizes the importance of good clinico-pathological liaison, especially in difficult cases.
authors.affiliation: Department of Otolaryngology, St Bartholomew's Hospital, London, UK. randm.persaud@ukgateway.net
authors.forename: Ricardo
authors.initials: R
authors.lastname: Persaud
authors.forename: Dil
authors.initials: D
authors.lastname: Vahidova
authors.forename: Claudia
authors.initials: C
authors.lastname: Kirsch
authors.forename: Maria
authors.initials: M
authors.lastname: Calaminici
authors.forename: Khalid
authors.initials: K
authors.lastname: Ghufoor
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005931:Glottis; D006097:Granulation Tissue / Q000473:pathology* / Q000601:surgery; D006394:Hemangiosarcoma / Q000175:diagnosis*; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis* / Q000601:surgery; D007822:Laryngeal Neoplasms / Q000175:diagnosis; D053685:Laser Therapy; D008297:Male