title: Heart rate influences on repolarization duration and morphology in symptomatic versus asymptomatic KCNQ1 mutation carriers.
abstract: QT and Tp/Te intervals were longer in patients with LQT1 (n = 67) than in nonaffected subjects (n = 52) but did not differentiate symptomatic (n = 21) from asymptomatic patients (n = 46). At fast heart rate, the time to accumulate the last part of total T-wave area (the t50-97 interval) was longer in symptomatic carriers compared with asymptomatic patients (119 +/- 19 vs 106 +/- 15 ms, p <0.01). The latter group had significantly longer t50-97 intervals than nonaffected subjects (96 +/- 14 ms, p <0.01).
authors.affiliation: Service de Cardiologie, Groupe Hospitalier Lariboisière, Paris, France. fabrice.extramiana@lrb.ap-hop-paris.fr
authors.forename: Fabrice
authors.initials: F
authors.lastname: Extramiana
authors.forename: Isabelle
authors.initials: I
authors.lastname: Denjoy
authors.forename: Fabio
authors.initials: F
authors.lastname: Badilini
authors.forename: Iheb
authors.initials: I
authors.lastname: Chabani
authors.forename: Nathalie
authors.initials: N
authors.lastname: Neyroud
authors.forename: Myriam
authors.initials: M
authors.lastname: Berthet
authors.forename: Véronique
authors.initials: V
authors.lastname: Fressard
authors.forename: Pascale
authors.initials: P
authors.lastname: Guicheney
authors.forename: Philippe
authors.initials: P
authors.lastname: Beaufils
authors.forename: Antoine
authors.initials: A
authors.lastname: Leenhardt
authors.forename: Philippe
authors.initials: P
authors.lastname: Coumel
authors.forename: Pierre
authors.initials: P
authors.lastname: Maison-Blanche
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002353:Carrier State; D016009:Chi-Square Distribution; D002648:Child; D015716:Electrocardiography, Ambulatory; D005260:Female; D005838:Genotype; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008133:Long QT Syndrome / Q000235:genetics* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics