Blood pressure response to strength training may be influenced by angiotensinogen A-20C and angiotensin II type I receptor A1166C genotypes in older men and women.
OBJECTIVE
To determine the influence of angiotensinogen (AGT) A-20C, M235 T, and angiotensin II type 1 receptor (AGTR1) A1166C genotypes on resting blood pressure (BP) response to strength training (ST) in older men and women.


METHODS
Prospective intervention study with retrospective genotyping.


METHODS
University of Maryland Exercise Physiology Laboratory.


METHODS
Seventy sedentary, healthy older men (n=34) and women (n=36).


METHODS
Approximately 23 weeks of ST performed 3 days per week.


METHODS
Resting BP was measured on six separate occasions before and after ST for each subject. AGT and AGTR1 genotyping was performed retrospectively from each subject's genomic deoxyribonucleic acid.


RESULTS
Systolic BP decreased in C-allele carriers at the AGT A-20C locus with ST (122+/-1 to 116+/-2 mmHg, P<.05), which was significantly greater than the decrease in the A homozygotes (126+/-1 to 123+/-1 mmHg, P<.05). At the AGTR1 A1166C locus, diastolic BP decreased to a greater extent in the C-allele carriers (76+/-1 to 70+/-2 mmHg, P<.05) than in the A homozygotes (75+/-1 to 72+/-1 mmHg, P<.05).


CONCLUSIONS
The AGT A-20C and AGTR1 A1166C genotypes may influence resting BP response to ST, such that C-allele carriers at each of these loci reduce their resting BP in response to ST to a greater extent than A homozygotes.
Delmonico
Matthew J
MJ
Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park, Maryland 20742, USA.
Ferrell
Robert E
RE
Meerasahib
Anish
A
Martel
Greg F
GF
Roth
Stephen M
SM
Kostek
Matthew C
MC
Hurley
Ben F
BF
D000368:Aged; D000369:Aged, 80 and over; D000808:Angiotensinogen / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D001823:Body Composition; D015444:Exercise / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000502:physiology*; D010807:Physical Endurance / Q000235:genetics*; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*
D044140:Receptor, Angiotensin, Type 1; D000808:Angiotensinogen