title: Discovering the mechanisms of neurodegeneration in prion diseases.
abstract: The purpose of my chapter in this issue of Neuroscience Reviews dedicated to Dr. Lawrence Eng is to summarize my contributions to understanding the mechanisms of neurodegeneration in prion diseases. I explain that I was able to advance the field of prion disease neuropathology largely because of the foundation of neurochemistry and immunohistochemistry that I learned while working 5 years in Dr. Eng's laboratory. In my review, I relate how my Neuropathology Research Laboratory began as a collaboration with Dr. Stanley Prusiner 20 years ago that led from immunohistochemical staining of amyloid plaques in rodent and human brains using prion protein-specific antibodies to molecular evidence that the abnormal prion protein, PrP(Sc), is the cause of the clinically relevant neuropathological changes in animal and human prion diseases.
authors.affiliation: Department of Pathology, Institute for Neurodegenerative Diseases, University of California, San Francisco, 94143-0511, USA. sdearmo@itsa.ucsf.edu
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: DeArmond
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D017096:Prion Diseases / Q000378:metabolism / Q000473:pathology*; D011328:Prions / Q000235:genetics / Q000378:metabolism
chemical_list: D011328:Prions