title: [Clinical features of 35 cases of autoimmune hepatitis-primary biliary cirrhosis overlap syndrome].
abstract: OBJECTIVE
  To realize the clinical features of autoimmune hepatitis-primary biliary cirrhosis (AIH+PBC) overlap syndrome.
  
  
  METHODS
  We analyzed and compared the biochemistry, autoimmune antibodies, and liver biopsy results of 129 autoimmune hepatic disease cases retrospectively, using the international criteria to see which could be diagnosed as AIH/PBC overlap syndrome.
  
  
  RESULTS
  Our 35 AIH+PBC overlap syndrome patients were mainly women, with a sex ratio of 1 female: 10 male, and a median age of 50.79+/-11.27 (20 to 70 years old). They had AIH characteristics such as flare of ALT, AST and elevated immunoglobulin G (IgG), gamma-immunoglobulin. There were also antinuclear antibodies (74.3%); moderate or severe periportal or periseptal lymphocytic infiltration, piecemeal necrosis, and florid bile duct lesions, high serum levels of ALP, presence of mitochondrial antibodies (68.6%) and M2 antibodies (45.7%), and features of PBC.
  
  
  CONCLUSIONS
  AIH+PBC overlap syndrome is not rare. It should be diagnosed in time and to find effective treatments for it.
authors.affiliation: 302 Hospital of PLA, Beijing 100039, China. zengzhen1@yahoo.com.cn
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zeng
authors.forename: Yu-Kun
authors.initials: YK
authors.lastname: Han
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Geng
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D001323:Autoantibodies; D002756:Cholagogues and Choleretics; D007074:Immunoglobulin G; D014580:Ursodeoxycholic Acid