Role of the hedgehog/patched signaling pathway in oncogenesis: a new polymorphism in the PTCH gene in ovarian fibroma.
We compared the expression of target genes of Hedgehog/Patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of heterozygosity findings in the PTCH locus and increased expression of several genes in the pathway strongly suggest that the pathway is involved in both ovarian fibroma and dermoids.
Levanat
Sonja
S
Laboratory of Molecular Oncology, Division of Molecular Medicine, Ruder Bosković Institute, Bijenićka 54, HR-10000 Zagreb, Croatia. levanat@rudjer.irb.hr
Musani
Vesna
V
Komar
Arijana
A
Oreskovic
S
S
D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D005350:Fibroma / Q000235:genetics*; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D053823:Hedgehog Proteins; D006801:Humans; D019656:Loss of Heterozygosity; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D010051:Ovarian Neoplasms / Q000235:genetics*; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*
D017931:DNA Primers; D053823:Hedgehog Proteins; D008565:Membrane Proteins; C000606236:PTCH1 protein, human; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; D011956:Receptors, Cell Surface; C509239:SHH protein, human; D015534:Trans-Activators