title: Prolonged survival after resection of liver metastases from uveal melanoma and intra-arterial chemotherapy.
abstract: BACKGROUND
  To report the protracted 9-year survival of a patient after surgical management of multiple liver metastases from uveal melanoma.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  A 30-year-old patient, treated for choroidal melanoma by proton beam therapy, was semiannually followed by abdominal ultrasonography. Two years after initial treatment, a total body computed tomography scan suggested the diagnosis of isolated liver metastases.
  
  
  RESULTS
  Multiple wedge resections and postoperative intra-arterial chemotherapy with fotemustine were performed. After 4 years, a metastatic nodule in the head of the pancreas was detected and surgically removed. Eighteen months later, metastases were progressively detected in other organs. The patient finally died of carcinomatous meningitis 9 years of first treatment of metastases.
  
  
  CONCLUSIONS
  In the present case, the surgical control of liver metastases associated with intra-arterial chemotherapy prolonged the quality and length of life with progressive disease extension to other organs.
authors.affiliation: Department of Ophthalmology, Croix-Rousse Hospital, 103 Grande rue de la Croix-Rousse, Lyon, 69004, France. kodjikian.laurent@wanadoo.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Kodjikian
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Grange
authors.forename: Michel
authors.initials: M
authors.lastname: Rivoire
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003606:Dacarbazine / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000401:mortality* / Q000556:secondary / Q000628:therapy; D008545:Melanoma / Q000401:mortality* / Q000556:secondary / Q000628:therapy; D009362:Neoplasm Metastasis; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D009943:Organophosphorus Compounds / Q000008:administration & dosage; D015996:Survival Rate; D013997:Time Factors; D014604:Uveal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy
chemical_list: D009607:Nitrosourea Compounds; D009943:Organophosphorus Compounds; D003606:Dacarbazine; C054368:fotemustine