title: Magnetic resonance detects brainstem changes in chronic, active heavy drinkers.
abstract: Neuropathological and neuroimaging studies show cortical and subcortical volume loss in alcohol-dependent individuals. Using quantitative magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopic imaging ((1)H MRSI), we studied the size and potential cellular injury of the brainstem in untreated heavy alcohol drinkers. The brainstem is considered critical in the development and maintenance of drug and alcohol dependence. Two methods of brainstem size determination were compared: standard volumetry vs. midsagittal MR image area measurement. Heavy drinkers (n=12) and light drinkers (n=10) were compared with MRI; (1)H MRSI brainstem data were obtained from a subset of this cohort. Chronic heavy drinking was associated with significantly smaller midsagittal areas of the brainstem, midbrain, and pons, and with significantly smaller overall brainstem volume. Heavy drinking was also associated with significantly lower ratios of N-acetyl-aspartate and choline-containing metabolites compared with creatine-containing compounds in the brainstem, independent of brainstem atrophy. Additionally, brainstem volume and midsagittal brainstem area were correlated (r=0.78). These structural and metabolite findings are consistent with neuronal injury in the brainstem of untreated chronic heavy drinkers. The results also indicate that the midsagittal MRI brainstem area is an easily determined and reliable indicator of brainstem volume.
authors.affiliation: University of Pennsylvania-Presbyterian Medical Center, Philadelphia, PA 19104, USA.
authors.forename: Courtnay W
authors.initials: CW
authors.lastname: Bloomer
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Langleben
authors.forename: Dieter J
authors.initials: DJ
authors.lastname: Meyerhoff
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000378:metabolism / Q000473:pathology* / Q000523:psychology; D001933:Brain Stem / Q000473:pathology*; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000378:metabolism; D012720:Severity of Illness Index
chemical_list: D012701:Serotonin