title: Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) in Hodgkin's disease: report of a case.
abstract: Liver involvement is common in advanced stages of Hodgkin's disease. However, only a small percentage of patients with Hodgkin's disease develops jaundice due to several causes. Vanishing bile duct syndrome secondary to Hodgkin's disease is a rare cause of cholestasis in these patients. Only 20 cases, to our knowledge, have been reported so far in adults. We report a case of Hodgkin's disease presenting with obstructive jaundice without detectable liver involvement. Liver biopsies revealed intrahepatic cholestasis and ductopenia. Although the patient was given chemotherapy, he died of sepsis and disseminated intravascular coagulation after 24 weeks of admission to hospital.
authors.affiliation: University of Kirikkale, Faculty of Medicine, Department of Gastroenterology, Kirikkale, Turkey. sguliter@hotmail.com
authors.forename: Sefa
authors.initials: S
authors.lastname: Guliter
authors.forename: Ozlem
authors.initials: O
authors.lastname: Erdem
authors.forename: Mine
authors.initials: M
authors.lastname: Isik
authors.forename: Kadri
authors.initials: K
authors.lastname: Yamac
authors.forename: Omer
authors.initials: O
authors.lastname: Uluoglu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001649:Bile Duct Diseases / Q000209:etiology; D001652:Bile Ducts / Q000473:pathology*; D002780:Cholestasis, Intrahepatic / Q000150:complications / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000209:etiology; D013577:Syndrome