Access to catheterisation facilities in patients admitted with acute coronary syndrome: multinational registry study.
OBJECTIVE
To investigate the relation between access to a cardiac catheterisation laboratory and clinical outcomes in patients admitted to hospital with suspected acute coronary syndrome.


METHODS
Prospective, multinational, observational registry.


METHODS
Patients enrolled in 106 hospitals in 14 countries between April 1999 and March 2003.


METHODS
28,825 patients aged > or = 18 years.


METHODS
Use of percutaneous coronary intervention or coronary artery bypass graft surgery, death, infarction after discharge, stroke, or major bleeding.


RESULTS
Most patients (77%) across all regions (United States, Europe, Argentina and Brazil, Australia, New Zealand, and Canada) were admitted to hospitals with catheterisation facilities. As expected, the availability of a catheterisation laboratory was associated with more frequent use of percutaneous coronary intervention (41% v 3.9%, P < 0.001) and coronary artery bypass graft (7.1% v 0.7%, P < 0.001). After adjustment for baseline characteristics, medical history, and geographical region there were no significant differences in the risk of early death between patients in hospitals with or without catheterisation facilities (odds ratio 1.13, 95% confidence interval 0.98 to 1.30, for death in hospital; hazard ratio 1.05, 0.93 to 1.18, for death at 30 days). The risk of death at six months was significantly higher in patients first admitted to hospitals with catheterisation facilities (hazard ratio 1.14, 1.03 to 1.26), as was the risk of bleeding complications in hospital (odds ratio 1.94, 1.57 to 2.39) and stroke (odds ratio 1.53, 1.10 to 2.14).


CONCLUSIONS
These findings support the current strategy of directing patients with suspected acute coronary syndrome to the nearest hospital with acute care facilities, irrespective of the availability of a catheterisation laboratory, and argue against early routine transfer of these patients to tertiary care hospitals with interventional facilities.
Van de Werf
Frans
F
Universitair Ziekenhuis Gasthuisberg, Herestraat 49, Leuven, Belgium 3000. frans.vandewerf@uz.kuleuven.ac.be
Gore
Joel M
JM
Avezum
Alvaro
A
Gulba
Dietrich C
DC
Goodman
Shaun G
SG
Budaj
Andrzej
A
Brieger
David
D
White
Kami
K
Fox
Keith A A
KA
Eagle
Kim A
KA
Kennelly
Brian M
BM
D000368:Aged; D006328:Cardiac Catheterization / Q000401:mortality / Q000706:statistics & numerical data*; D005260:Female; D006297:Health Services Accessibility / Q000706:statistics & numerical data*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality / Q000628:therapy*; D009204:Myocardial Revascularization / Q000401:mortality / Q000706:statistics & numerical data; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D012111:Residence Characteristics; D012307:Risk Factors