title: [What has changed in knowledge of etiopathogenensis, diagnostics and therapy of gastroesophageal reflux over last 15 years?].
abstract: An incidence of gastroesophageal reflux disease (GERD) in population is continuously increasing. A probable etiology, except anatomical changes (such as hiatus hernia, transient lower esophageal sphincter relaxation etc.), can also include a change in life style For diagnostic purposes upper endoscopy and in unclear cases esophageal pH-metry is used. From an etiopathogenetic point of view, besides reflux of acidic content, the alkaline content and night change in production of hydrochloric acid during treatment with proton pump blockers (PPI) are considered to be important too. Attention should be paid to extraesophageal signs of GERD. In treatment prevail PPI, in resistant cases and in younger patients fundoplications are considered, and, also therapeutic endoscopy becomes more important (application of gel prostheses, electricity to cardiac part followed with scaring or ligatures).
authors.affiliation: Interní gastroenterologická klinika Lékarské fakulty MU a FN Brno.
authors.forename: A
authors.initials: A
authors.lastname: Hep
mesh_terms: D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006801:Humans