title: Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B.
abstract: By targeting dual active sites of AChE, a number of new derivatives of HupB have been synthesized and tested as acetylcholinesterase inhibitors. The most potent compound, bis-HupB 5b is 72-fold more potent in AChE inhibition and 79-fold more selective for AChE versus BChE than HupB.
authors.affiliation: State Key Laboratory for New Drug Research, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
authors.forename: Song
authors.initials: S
authors.lastname: Feng
authors.forename: Yu
authors.initials: Y
authors.lastname: Xia
authors.forename: Dongmei
authors.initials: D
authors.lastname: Han
authors.forename: Chunyan
authors.initials: C
authors.lastname: Zheng
authors.forename: Xuchang
authors.initials: X
authors.lastname: He
authors.forename: Xican
authors.initials: X
authors.lastname: Tang
authors.forename: Donglu
authors.initials: D
authors.lastname: Bai
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites; D002540:Cerebral Cortex; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; C053016:huperzine B