title: Comparison of the hepatic perfusion index measured with gadolinium-enhanced volumetric MRI in controls and in patients with colorectal cancer.
abstract: The aim of the study was to adapt the methodology established for dynamic CT measurements of the hepatic perfusion index (HPI) to MRI, and to assess the potential role of MRI measurements of the HPI in detecting regional alterations in liver perfusion between patients with colorectal liver metastases and normal controls. The HPI was evaluated from serial T(1) volume acquisitions acquired over the course of a Gd-DTPA bolus injection. Time-course data from regions of interest in the liver, spleen and aorta were used to calculate the HPI; and HPI data from control subjects were compared with data from patients with known colorectal metastases. Significant differences were found between the relative portal perfusion and hepatic perfusion indices calculated for the patient and control groups (p<0.005). These results suggest that hepatic perfusion indices can be derived using MRI-based methods, and that these perfusion indices are sensitive to differences in liver perfusion associated with established metastatic liver disease on imaging. This technique may contribute to the early detection of liver metastases, allowing early surgical intervention and improved patient survival.
authors.affiliation: Department of Radiology, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
authors.forename: J J
authors.initials: JJ
authors.lastname: Totman
authors.forename: R L
authors.initials: RL
authors.lastname: O'gorman
authors.forename: P A
authors.initials: PA
authors.lastname: Kane
authors.forename: J B
authors.initials: JB
authors.lastname: Karani
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms; D003287:Contrast Media; D042241:Early Diagnosis; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008099:Liver / Q000098:blood supply*; D008102:Liver Circulation / Q000502:physiology*; D008113:Liver Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000556:secondary*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA