Ramipril-induced agranulocytosis confirmed by a lymphocyte cytotoxicity test.
A 50-year-old man who had chronic renal failure presented with neutropenic fever four days after ramipril was initiated. Agranulocytosis due to other causes was ruled out after a bone marrow aspiration and biopsy examination were performed. A relationship between the drug and the adverse effect was suggested. It was established by a novel lymphocyte cytotoxicity test.
Horowitz
Nathaniel
N
Department of Internal Medicine D and the Immunology and Allergy Institute, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. n_horowitz@rambam.health.gov.il
Molnar
Madlen
M
Levy
Yishai
Y
Pollack
Shimon
S
D000380:Agranulocytosis / Q000139:chemically induced* / Q000175:diagnosis*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D017257:Ramipril / Q000009:adverse effects*
D000806:Angiotensin-Converting Enzyme Inhibitors; D017257:Ramipril