Efficacy and safety of the ketogenic diet for intractable childhood epilepsy: Korean multicentric experience.
OBJECTIVE
We wished to evaluate the efficacy and safety of the ketogenic diet (KD), and we also evaluated the prognosis of the patients after successful discontinuation of the diet in infants, children, and adolescents with refractory epilepsy.


METHODS
This was a retrospective study of epilepsy patients treated with the KD during 1995 through 2003 at the Korean multicenters. Outcome measures included seizure frequency, electroencephalography (EEG), adverse reactions, and antiepileptic drug (AED) number. The variables related to the efficacy and prognosis also were analyzed.


RESULTS
The outcomes of the 199 patients enrolled in this study at 6 and 12 months after the diet were revealed; 68% and 46% of patients remained on the diet, 58% and 41% showed a reduction of seizure frequency of >50%, including 33% and 25% who became seizure free, respectively. Finally, 66 (34%) of 199 patients successfully completed or maintained the diet. EEGs showed an improvement in background in 40 (72.7%) of 55 patients and a reduction in generalized and focal discharges in 41 (57.7%) of 71 and 15 (33.3%) of 45 patients. Most complications were mild, but five patients died during the KD. No significant variables were related to the efficacy, but those with symptomatic (p=0.047) and partial epilepsies (p=0.073) showed more frequent relapse after completion of the diet.


CONCLUSIONS
The KD is a safe and effective alternative therapy for intractable childhood epilepsy in Korea, although the customary diet contains substantially less fat than traditional Western diets, but life-threatening complications should be monitored closely during follow-up.
Kang
Hoon Chul
HC
Department of Pediatrics, Epilepsy Center, Inje University College of Medicine, Sanggye Paik Hospital, Seoul, Korea.
Kim
Yong Joo
YJ
Kim
Dong Wook
DW
Kim
Heung Dong
HD
D000293:Adolescent; D002648:Child; D002985:Clinical Protocols; D003431:Cross-Cultural Comparison; D004035:Diet Therapy / Q000379:methods; D004041:Dietary Fats / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use*; D004827:Epilepsy / Q000175:diagnosis / Q000178:diet therapy* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007662:Ketosis / Q000209:etiology / Q000378:metabolism*; D007723:Korea; D008297:Male; D011379:Prognosis; D016896:Treatment Outcome
D004041:Dietary Fats