title: [Two approaches to correction of disturbed hemostasis in patients with mechanical artificial heart valves at the long-term follow-up].
abstract: The investigation of the hemostasis system performed in 47 patients with mechanical heart valves (MHV) at the terms of (3.50 +/- 0.25) years included 30 men and 17 women. There were 24 cases of aortal MHV and 23 cases of mitral MHV, I-II functional class (NYHA). The patients were given oral anticoagulants: phenylin to 35 patients (0.009 mg/day), varfarin to 12 patients (52.6 mg/a week). The primary examination of the patients has revealed insufficient anticoagulation protection and clinically asymptomatic permanent intravascular coagulation of the third degree (PIC-3), with the signs of activation of thrombocytic and/or coagulation link of hemostasis. It has been found that a complex assessment of the hemostasis system state including the vascular-thrombocytic link is an obligatory condition of the right choice and timely correction of the PIC-3 in patients with MHV. The methods of correction of impaired hemostasis depend on the primary involvement of the vascular-thrombocytic and/or coagulation link of hemostasis. The pathogenetically selected antithrombotic therapy for patients with MHV allows timely arrest of PIC-3 and less risk of the development of thrombosis and thrombo-embolic complications at long-term periods of observation.
authors.forename: P I
authors.initials: PI
authors.lastname: Orlovskiĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Gritsenko
authors.forename: T V
authors.initials: TV
authors.lastname: Vavilova
authors.forename: M I
authors.initials: MI
authors.lastname: Kadinskaia
authors.forename: T I
authors.initials: TI
authors.lastname: Petrishina
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Mochalov
authors.forename: D A
authors.initials: DA
authors.lastname: Polezhaev
authors.forename: A N
authors.initials: AN
authors.lastname: Galileeva
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects*; D000077144:Clopidogrel; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D017762:Nadroparin / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D013923:Thromboembolism / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D017762:Nadroparin; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin