title: Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats.
abstract: Tea catechins, (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG), and (-)-epigallocatechin gallate (EGCG), have been shown to be epimerized to (-)-catechin (C), (-)-gallocatechin (GC), (-)-catechin gallate (CG), and (-)-gallocatechin gallate (GCG), respectively, during heat treatment. In this study, we examined the effect of tea catechins rich in ECG and EGCG and heat-treated tea catechins rich in CG and GCG on postprandial hypertriacylglycerolemia in rats. Both tea catechins and heat-treated tea catechins suppressed postprandial hypertriacylglycerolemia. Lymphatic recovery of (14)C-trioleoylglycerol in rats cannulated in the thoracic duct was delayed by the administration of tea catechins and heat-treated tea catechins. Tea catechins and heat-treated tea catechins had the same effect on all variables tested. These catechin preparations dose-dependently inhibited the activity of pancreatic lipase in vitro. When purified catechins were used, only those with a galloyl moiety inhibited the activity of pancreatic lipase. These results suggest that catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by slowing down triacylglycerol absorption through the inhibition of pancreatic lipase. Because postprandial hypertriacylglycerolemia is a risk factor for coronary heart disease, our results suggest that catechins with a galloyl moiety may prevent this disease.
authors.affiliation: Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812-8581, Japan. iikeda@agr.kyushu-u.ac.jp
authors.forename: Ikuo
authors.initials: I
authors.lastname: Ikeda
authors.forename: Koichi
authors.initials: K
authors.lastname: Tsuda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Tomonori
authors.initials: T
authors.lastname: Unno
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tomoyori
authors.forename: Hitomi
authors.initials: H
authors.lastname: Goto
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Kawata
authors.forename: Katsumi
authors.initials: K
authors.lastname: Imaizumi
authors.forename: Ayumu
authors.initials: A
authors.lastname: Nozawa
authors.forename: Takami
authors.initials: T
authors.lastname: Kakuda
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002392:Catechin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000494:pharmacology*; D004041:Dietary Fats / Q000378:metabolism*; D015228:Hypertriglyceridemia / Q000517:prevention & control*; D008208:Lymphatic System / Q000187:drug effects / Q000502:physiology*; D008297:Male; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar; D013662:Tea
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D013662:Tea; D002392:Catechin; C062669:epicatechin gallate; C045651:epigallocatechin gallate; C057580:gallocatechol