title: Genome screen in the French EGEA study: detection of linked regions shared or not shared by allergic rhinitis and asthma.
abstract: In the sample of 295 French EGEA families with at least one asthmatic subject, a genome screen was conducted to identify potential linkage regions specific either to allergic rhinitis (AR) or to asthma as well as those shared by the two diseases. Two binary rhinitis phenotypes based on (1) diagnosis (ARbin1) and (2) symptoms (ARbin2) and a categorical ordered trait (ARcat) were considered. Asthma phenotype was based on answers to a standardized questionnaire plus the presence of bronchial hyper-responsiveness. Linkage analyses were conducted using the maximum likelihood binomial (MLB) method. These analyses provided potential evidence for linkage to three regions in the whole sample: 1p31 for the phenotype defined by ARbin2 plus asthma (P=0.00016), 2q32 for ARbin2 (P=0.00016) and 3p24-p14 for ARcat (P=0.001). Two other regions were detected in the subset of 185 families with at most one asthmatic sib: 9p22 and 9q22-q34 for ARbin1 (P=0.001 and 0.0007, respectively). No region showed evidence for linkage to asthma without being also linked to AR. While 1p31 may contain a genetic determinant common to asthma and AR, 2q32, 3p24-p14, 9p22 and 9q22-q34 are more likely to harbor genetic factors specific to AR.
authors.affiliation: INSERM U535, Hôpital Paul Brousse, Bâtiment Leriche, Villejuif Cedex, France. dizier@vjf.inserm.fr
authors.forename: M-H
authors.initials: MH
authors.lastname: Dizier
authors.forename: E
authors.initials: E
authors.lastname: Bouzigon
authors.forename: M
authors.initials: M
authors.lastname: Guilloud-Bataille
authors.forename: C
authors.initials: C
authors.lastname: Bétard
authors.forename: J
authors.initials: J
authors.lastname: Bousquet
authors.forename: D
authors.initials: D
authors.lastname: Charpin
authors.forename: F
authors.initials: F
authors.lastname: Gormand
authors.forename: J
authors.initials: J
authors.lastname: Hochez
authors.forename: J
authors.initials: J
authors.lastname: Just
authors.forename: A
authors.initials: A
authors.lastname: Lemainque
authors.forename: N
authors.initials: N
authors.lastname: Le Moual
authors.forename: R
authors.initials: R
authors.lastname: Matran
authors.forename: F
authors.initials: F
authors.lastname: Neukirch
authors.forename: M-P
authors.initials: MP
authors.lastname: Oryszczyn
authors.forename: E
authors.initials: E
authors.lastname: Paty
authors.forename: I
authors.initials: I
authors.lastname: Pin
authors.forename: D
authors.initials: D
authors.lastname: Vervloet
authors.forename: F
authors.initials: F
authors.lastname: Kauffmann
authors.forename: M
authors.initials: M
authors.lastname: Lathrop
authors.forename: F
authors.initials: F
authors.lastname: Demenais
authors.forename: I
authors.initials: I
authors.lastname: Annesi-Maesano
mesh_terms: D001249:Asthma / Q000235:genetics*; D002877:Chromosomes, Human / Q000235:genetics*; D005602:France; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D010641:Phenotype; D012220:Rhinitis / Q000235:genetics*
chemical_list: D005819:Genetic Markers