[Anti-Ri paraneoplastic syndrome associated with ophtalmoplegia, blepharospasm and palilalia].
BACKGROUND
Anti-Hu and anti-Yo are the most well-known anti-neuronal antibodies. The anti-Ri antibodies, which are less common, are generally found in subjects with opsoclonus-myoclonus, often associated with breast cancer.


METHODS
A 54-year-old woman presented anti-Ri antibodies associated with a paraneoplastic syndrome and unusual symptoms of ophthalmoplegia, blepharospasm, palilalia and ataxia. Adenocarcinoma of the breast was also found. After chemotherapy, radiotherapy, and several immunoglobulin infusions, the patient did not improve ten months after tumor surgery.


CONCLUSIONS
Anti-Ri antibodies associated with paraneoplastic syndrome can be observed in patients who develop a rapidly progressive brainstem tumor. Breast or lung cancer and conduct to search a breast or pulmonary cancer.
Martinaud
O
O
Département de Neurologie, Hôpital Charles Nicolle, CHU de Rouen.
Guegan-Massardier
E
E
Iasci
L
L
Miret
N
N
Mihout
B
B
Hannequin
D
D
D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy / Q000628:therapy; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology*; D001764:Blepharospasm / Q000209:etiology* / Q000276:immunology; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy / Q000628:therapy; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D008875:Middle Aged; D009886:Ophthalmoplegia / Q000209:etiology* / Q000276:immunology; D020361:Paraneoplastic Syndromes, Nervous System / Q000150:complications* / Q000276:immunology; D013064:Speech Disorders / Q000209:etiology*
D000970:Antineoplastic Agents; D001323:Autoantibodies