Natural antioxidant L-carnosine inhibits LPO intensification in structures of the auditory analyzer under conditions of chronic exposure to aminoglycoside antibiotics.
Intragastric administration of L-carnosine suspension to Wistar-Kyoto rats 3 days before and after 7-day course of intraperitoneal injections of ototoxic aminoglycoside antibiotic kanamycin compensated expenditures of tissue antioxidant systems and significantly eliminated kanamycin-induced intensification of MDA production in tissues of the membrane part of the cochlea and in the auditory cortex of the temporal lobe. L-NAME (competitive NO synthase inhibitor) also inhibited LPO, increased total antioxidant activity, and decreased ototoxicity of kanamycin, which confirms the contribution of NO into LPO intensification under conditions of aminoglycoside treatment. Inhibition of pathological intensification of LPO processes and increase in total antioxidant activity under conditions of induced acute aminoglycoside ototoxicity characterizes L-carnosine as a highly effective otoprotector.
Zhuravskii
S G
SG
Laboratory of Hearing and Speech, Department of Biochemistry, Research Center, I. P. Pavlov State Medical University, St. Petersburg. sjour@spmu.rssi.ru
Aleksandrova
L A
LA
Sirot
V S
VS
Ivanov
S A
SA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology*; D001303:Auditory Cortex / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism*; D002336:Carnosine / Q000494:pharmacology*; D003051:Cochlea / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism*; D007612:Kanamycin / Q000008:administration & dosage / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D051381:Rats; D011921:Rats, Inbred WKY
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D008315:Malondialdehyde; D007612:Kanamycin; D002336:Carnosine; D019331:NG-Nitroarginine Methyl Ester