title: Pharmacomodulation of a sulfamide 5-HT6 receptor ligand.
abstract: A series of N-omega-aminoalkyl- or N-omega-amidinoalkyl-2,4,6-triisopropyl benzenesulfonamides has been synthesized and their respective affinity indices on 5-HT6 receptor determined. This evaluation clearly showed that the compounds possessing an arylpiperazine moiety or an amidine function exhibited good affinity for the model.
authors.affiliation: UPRES EA 2234- Institut de Chimie de Rennes, Faculté des Sciences Biologiques et Médicales, Université de Rennes 1, 35043 Rennes, France. jacques.renault@univ-rennes1.fr
authors.forename: Jacques
authors.initials: J
authors.lastname: Renault
authors.forename: Aurelie
authors.initials: A
authors.lastname: Bernard
authors.forename: Solenn
authors.initials: S
authors.lastname: Brajeul
authors.forename: Pierre
authors.initials: P
authors.lastname: Verhaeghe
authors.forename: Sabrina
authors.initials: S
authors.lastname: Butt
authors.forename: Frederic
authors.initials: F
authors.lastname: Fabis
authors.forename: François
authors.initials: F
authors.lastname: Dauphin
authors.forename: Philippe
authors.initials: P
authors.lastname: Uriac
authors.forename: Sylvain
authors.initials: S
authors.lastname: Rault
mesh_terms: D015195:Drug Design; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D011985:Receptors, Serotonin / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000096926:Benzenesulfonamides
chemical_list: D008024:Ligands; D011985:Receptors, Serotonin; D013449:Sulfonamides; D000096926:Benzenesulfonamides; C097216:serotonin 6 receptor