A family-based association study of the MOG gene with schizophrenia in the Chinese population.
Recently the expression of human myelin/oligodendrocyte glycoprotein (MOG) has been found to be significantly downregulated in the brain tissue of subjects with schizophrenia, suggesting that the MOG gene resides within a high-susceptibility locus for schizophrenia. In order to test this prediction, we analyzed three microsatellites from MOG in the Han Chinese population using a sample of 532 trios. Analysis of allele, genotype and haplotype frequencies showed weak positive association between the markers and the disease (p=0.01982). Our results would indicate that the MOG gene may play a significant role in schizophrenia in the Han Chinese. However, further study is required using other methods and involving other populations.
Liu
Xinmin
X
Bio-X Life Science Research Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, P.R. China.
Qin
Wei
W
He
Guang
G
Yang
Yifeng
Y
Chen
Qi
Q
Zhou
Jian
J
Li
Dawei
D
Gu
Niufan
N
Xu
Yifeng
Y
Feng
Guoyin
G
Sang
Hong
H
Hao
Xinming
X
Zhang
Kui
K
Wang
Shiji
S
He
Lin
L
D044466:Asian People / Q000235:genetics*; D002681:China; D002874:Chromosome Mapping; D017931:DNA Primers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats / Q000235:genetics; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000235:genetics*; D063308:Myelin-Oligodendrocyte Glycoprotein; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*
D017931:DNA Primers; C571326:MOG protein, human; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein