title: Lunatic fringe null female mice are infertile due to defects in meiotic maturation.
abstract: We have demonstrated that Notch genes are expressed in developing mammalian ovarian follicles. Lunatic fringe is an important regulator of Notch signaling. In this study, data are presented that demonstrate that radical fringe and lunatic fringe are expressed in the granulosa cells of developing follicles. Lunatic fringe null female mice were found to be infertile. Histological analysis of the lunatic fringe-deficient ovary demonstrated aberrant folliculogenesis. Furthermore, oocytes from these mutants did not complete meiotic maturation. This is a novel observation because this is the first report describing a meiotic defect that results from mutations in genes that are expressed in the somatic granulosa cells and not the oocytes. This represents a new role for the Notch signaling pathway and lunatic fringe in mammalian folliculogenesis.
authors.affiliation: Molecular and Cellular Graduate Program, Arizona State University, Tempe, AZ 85284-4501, USA.
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Hahn
authors.forename: Joshua
authors.initials: J
authors.lastname: Johnson
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Beres
authors.forename: Sheena
authors.initials: S
authors.lastname: Howard
authors.forename: Jeanne
authors.initials: J
authors.lastname: Wilson-Rawls
mesh_terms: D000818:Animals; D005260:Female; D016695:Glycosyltransferases / Q000172:deficiency / Q000235:genetics*; D006107:Granulosa Cells / Q000166:cytology / Q000378:metabolism; D007247:Infertility, Female / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D008540:Meiosis / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009024:Morphogenesis / Q000235:genetics / Q000502:physiology; D009865:Oocytes / Q000254:growth & development / Q000378:metabolism; D006080:Ovarian Follicle / Q000254:growth & development* / Q000378:metabolism; D051880:Receptors, Notch; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*
chemical_list: D008565:Membrane Proteins; D051880:Receptors, Notch; D016695:Glycosyltransferases; C498392:Lfng protein, mouse