title: Influence of angiotensin-converting enzyme I/D gene polymorphism on the right ventricular myocardial performance index in patients with a first acute anterior myocardial infarction.
abstract: BACKGROUND
  The genetic influence on the myocardial performance index is uncertain, so the aim of the present study was to determine the effects of polymorphism of the angiotensin-converting enzyme (ACE) gene on the right ventricular myocardial performance index (RVMPI) after a first acute anterior myocardial infarction (MI).
  
  
  RESULTS
  The subjects were 116 patients with a first acute anterior MI. Based on the polymorphism of the ACE gene, they were classified into 3 groups: deletion/deletion (DD) genotype (group 1, n=45), insertion/deletion (ID) genotype (group 2, n=58), insertion/insertion (II) genotype (group 3, n=13). Echocardiograms were used to determine the RVMPI, left ventricular myocardial performance index (LVMPI), tricuspid E/A, tricuspid deceleration time and the left ventricular diameter diastolic and diameter systolic (LVDd and LVDs). RVMPI and LVMPI were significantly higher in the ACE DD group. Tricuspid E/A, DT, LVDd and LVDs showed no differences among the 3 groups.
  
  
  CONCLUSIONS
  The ID polymorphism of the ACE gene may affect RVMPI and LVMPI after a first acute anterior MI.
authors.affiliation: Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey. droozturk21@yahoo.com
authors.forename: Onder
authors.initials: O
authors.lastname: Ozturk
authors.forename: Mehmet S
authors.initials: MS
authors.lastname: Ulgen
authors.forename: Selahattin
authors.initials: S
authors.lastname: Tekes
authors.forename: Unal
authors.initials: U
authors.lastname: Ozturk
authors.forename: Nizamettin
authors.initials: N
authors.lastname: Toprak
mesh_terms: D000368:Aged; D004252:DNA Mutational Analysis; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D009203:Myocardial Infarction / Q000235:genetics* / Q000503:physiopathology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017384:Sequence Deletion; D018487:Ventricular Dysfunction, Left / Q000235:genetics; D018497:Ventricular Dysfunction, Right / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A