Do non-steroidal anti-inflammatory drugs adversely affect stress fracture healing? A short review.
A literature search was performed to determine whether non-steroidal anti-inflammatory drugs (NSAIDs) adversely affect the healing of stress fractures. Evidence exists from laboratory studies and animal subjects that NSAIDs can affect fracture healing. This link has not been proved or disproved in human subjects, particularly for stress fractures. In view of the high usage of NSAIDs in treating musculoskeletal disorders, research is required to investigate whether the healing of stress fractures is affected by these drugs.
Wheeler
P
P
Leicester General Hospital, Department of Sports Medicine, Gwendolen Road, Leicester LE5 4PW, UK. patrickwheeler@doctors.org.uk
Batt
M E
ME
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D017102:Fracture Healing / Q000187:drug effects*; D015775:Fractures, Stress / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D010146:Pain / Q000188:drug therapy; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011451:Prostaglandin-Endoperoxide Synthases