title: Angiographic and clinical outcomes associated with direct versus conventional stenting among patients treated with fibrinolytic therapy for ST-elevation acute myocardial infarction.
abstract: The present study reports outcomes of direct stenting versus conventional stenting, which was performed during adjunctive/rescue percutaneous coronary intervention (n = 556) in the Integrilin and Tenecteplase in Acute Myocardial Infarction trial, the Enoxaparin as Adjunctive Antithrombin Therapy for ST-Elevation Myocardial Infarction-Thrombolysis in Myocardial Infarction 23 trial, and the Fibrinolytic and Aggrastat ST-Elevation Resolution trial of fibrinolytic therapy in ST-elevation myocardial infarction. Direct stenting was associated with a lower rate of death, myocardial infarction, or congestive heart failure during hospitalization and at 30 days and was independently associated with improved in-hospital outcomes (odds ratio 0.44, 95% confidence interval 0.23 to 0.85, p = 0.014).
authors.affiliation: Department of Medicine, Brigham & Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Hung Q
authors.initials: HQ
authors.lastname: Ly
authors.forename: Ajay J
authors.initials: AJ
authors.lastname: Kirtane
authors.forename: Jacki
authors.initials: J
authors.lastname: Buros
authors.forename: Robert P
authors.initials: RP
authors.lastname: Giugliano
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Popma
authors.forename: Elliot M
authors.initials: EM
authors.lastname: Antman
authors.forename: Robert A
authors.initials: RA
authors.lastname: Harrington
authors.forename: E Magnus
authors.initials: EM
authors.lastname: Ohman
authors.forename: C Michael
authors.initials: CM
authors.lastname: Gibson
mesh_terms: D002986:Clinical Trials as Topic; D017023:Coronary Angiography; D003627:Data Interpretation, Statistical; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006333:Heart Failure / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D015607:Stents; D015912:Thrombolytic Therapy; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents