title: A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.
abstract: The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.
authors.affiliation: Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, United Kingdom. aeelopresti@dstl.gov.uk
authors.forename: Angela E
authors.initials: AE
authors.lastname: Essex-Lopresti
authors.forename: Justin A
authors.initials: JA
authors.lastname: Boddey
authors.forename: Richard
authors.initials: R
authors.lastname: Thomas
authors.forename: Martin P
authors.initials: MP
authors.lastname: Smith
authors.forename: M Gill
authors.initials: MG
authors.lastname: Hartley
authors.forename: Timothy
authors.initials: T
authors.lastname: Atkins
authors.forename: Nat F
authors.initials: NF
authors.lastname: Brown
authors.forename: Chuk Hai
authors.initials: CH
authors.lastname: Tsang
authors.forename: Ian R A
authors.initials: IR
authors.lastname: Peak
authors.forename: Jim
authors.initials: J
authors.lastname: Hill
authors.forename: Ifor R
authors.initials: IR
authors.lastname: Beacham
authors.forename: Richard W
authors.initials: RW
authors.lastname: Titball
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion / Q000235:genetics / Q000502:physiology*; D016957:Burkholderia pseudomallei / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D017173:Caenorhabditis elegans / Q000378:metabolism / Q000382:microbiology; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000378:metabolism / Q000382:microbiology; D036781:Fimbriae Proteins / Q000378:metabolism*; D010861:Fimbriae, Bacterial / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D013997:Time Factors
chemical_list: D036781:Fimbriae Proteins