title: Multiple pathologies in a patient with a progressive neurodegenerative syndrome.
abstract: A woman presenting with levodopa responsive Parkinsonism developed rapidly progressive bulbar signs, quadriparesis, and upper and lower motor neurone signs. At necropsy, she was found to have three pathological diagnoses: amyotrophic lateral sclerosis, Parkinson's disease, and abundant tau-positive argyrophilic neuritic pathology, known as argyrophilic grain disease. This case raises the possibility that three distinct neuropathological diagnoses share a common aetiology.
authors.affiliation: Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. liangtw@mail.med.upenn.edu
authors.forename: T-W
authors.initials: TW
authors.lastname: Liang
authors.forename: M S
authors.initials: MS
authors.lastname: Forman
authors.forename: J E
authors.initials: JE
authors.lastname: Duda
authors.forename: L
authors.initials: L
authors.lastname: McCluskey
authors.forename: J Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: A
authors.initials: A
authors.lastname: Siderowf
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000473:pathology*; D001344:Autopsy; D001927:Brain Diseases / Q000150:complications / Q000473:pathology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000473:pathology*; D016875:tau Proteins / Q000032:analysis
chemical_list: D016875:tau Proteins