title: A role for the Wilms' tumor protein WT1 in organ development.
abstract: Wilms' tumor (nephroblastoma) represents a unique example of an aberrant kidney formation that can result from mutations in a tumor suppressor gene, Wilms' tumor 1 (WT1). Targeted gene inactivation in mice testifies that WT1 is a master switch for the development of the genitourinary system and other organs.
authors.affiliation: Johannes-Müller-Institut für Physiologie, Charité-Universitätsmedizin Berlin, Berlin, Germany. holger.scholz@charite.de
authors.forename: Holger
authors.initials: H
authors.lastname: Scholz
authors.forename: Karin M
authors.initials: KM
authors.lastname: Kirschner
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000502:physiology; D006321:Heart / Q000196:embryology*; D006801:Humans; D007668:Kidney / Q000196:embryology* / Q000502:physiology; D025721:WT1 Proteins / Q000502:physiology*
chemical_list: D025721:WT1 Proteins