title: Enterovirus protein 2B po(u)res out the calcium: a viral strategy to survive?
abstract: Enteroviruses modify several cellular functions to ensure efficient replication. However, some of these alterations can trigger a defensive apoptotic host-cell program. To prevent premature abortion of their productive cycle, enteroviruses have developed anti-apoptotic countermeasures. Here, we discuss recent evidence that the enterovirus 2B protein exerts an anti-apoptotic activity that is related to its ability to form pores in endoplasmic reticulum (ER) and Golgi membranes, thereby reducing their Ca(2+) content and perturbing ER-mitochondrial Ca(2+) signaling.
authors.affiliation: Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen Center for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands. f.vankuppeveld@ncmls.kun.nl
authors.forename: Frank J M
authors.initials: FJ
authors.lastname: van Kuppeveld
authors.forename: Arjan S
authors.initials: AS
authors.lastname: de Jong
authors.forename: Willem J G
authors.initials: WJ
authors.lastname: Melchers
authors.forename: Peter H G M
authors.initials: PH
authors.lastname: Willems
mesh_terms: D000595:Amino Acid Sequence; D017209:Apoptosis / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D004721:Endoplasmic Reticulum / Q000378:metabolism / Q000821:virology; D004770:Enterovirus / Q000235:genetics / Q000378:metabolism*; D004769:Enterovirus Infections / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006056:Golgi Apparatus / Q000378:metabolism / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D014764:Viral Proteins; D002118:Calcium