Dietary carbohydrates and glycated proteins in the blood in non diabetic subjects.
OBJECTIVE
To evaluate in non diabetic subjects the association of dietary carbohydrates with fructosamine, a measure of total non enzymatic glycated proteins in the blood associated with mortality, particularly from cardiovascular diseases.


METHODS
A population sample of 252 subjects (137 men and 115 women, mean age 57) without diabetes and with fasting serum glucose <126 mg/100 mL, participated in the study. Diet and dietary glycemic load were measured with a validated food frequency questionnaire. Fructosamine was measured with a standard colorimetric method. Multiple linear regression was used to analyze the data.


RESULTS
Serum fructosamine was positively associated with dietary glycemic load. Moreover, it was positively associated with intake of polyunsaturated fats and alcohol; and negatively with intake of monounsaturated fats, and with physical activity.


CONCLUSIONS
The quality of carbohydrate and fat, as well as physical activity, may explain the variation of non enzymatic glycated serum proteins in non diabetic subjects.
Misciagna
Giovanni
G
Laboratory of Epidemiology, IRCCS S. De Bellis, Research Hospital for Digestive Diseases, Castellana, (Bari), 70013, ITALY. gmisciag@libero.it
De Michele
Giampietro
G
Cisternino
Anna M
AM
Guerra
Vito
V
Logroscino
Giancarlo
G
Freudenheim
Jo L
JL
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005260:Female; D019270:Fructosamine / Q000097:blood*; D038321:Glycemic Index; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D019270:Fructosamine