title: Chorioamnionitis risk and neonatal outcome in preterm premature rupture of membranes.
abstract: OBJECTIVE
  The objective of this study was to compare the neonatal outcome in patients with preterm premature rupture of membranes with and without clinical chorioamnionitis.
  
  
  METHODS
  This is a retrospective study that included 254 pregnant women with preterm rupture of membranes. The study group was divided according to the presence or absence of clinical chorioamnionitis defined as the presence of two or more of the following criteria: maternal temperature >38 degrees C on two or more occasions > or =1 h apart, maternal tachycardia (> or =120 beats/min), uterine tenderness, foul smelling amniotic fluid, maternal leukocytosis > or =20,000 mm(-3) with bands and positive C reactive protein. Also the study population was divided according to the use of tocolysis. Exclusion criteria included multiple pregnancy, fetal congenital anomalies, diabetes mellitus and severe preeclampsia. Amniotic fluid was collected from the cervix or from the transabdominal amniocentesis. Antibiotics and tocolysis were used according to the hospital protocols. Parametric and nonparametric statistics were used for comparisons.
  
  
  RESULTS
  There were no significant differences in birth weight, Apgar scores at 1 and 5 min, rates of respiratory distress syndrome, intraventricular hemorrhage and necrotizing enterocolitis between patients with and without clinical chorioamnionitis or between women who received tocolysis and the ones that did not receive tocolysis. In cases of clinical chorioamnionitis and when tocolysis was used the neonates stayed longer in the neonatal intensive care unit (NICU).
  
  
  CONCLUSIONS
  Patients with preterm premature rupture of membranes and clinical chorioamnionitis have similar neonatal outcomes than the ones without clinical chorioamnionitis.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey. osmanaga@meds.ktu.edu.tr
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Osmanağaoğlu
authors.forename: Sevilay
authors.initials: S
authors.lastname: Unal
authors.forename: Hasan
authors.initials: H
authors.lastname: Bozkaya
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001034:Apgar Score; D002585:Cesarean Section / Q000706:statistics & numerical data; D002821:Chorioamnionitis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors; D015145:Tocolysis
chemical_list: D000900:Anti-Bacterial Agents