Antagonizing Wnt and FGF receptors: an enemy from within (the ER).
In this issue of Cell, Yamamoto et al. (2005) describe a novel molecule, Shisa, which functions in the endoplastic reticulum (ER) to prevent maturation of Frizzled (Fz) serpentine receptors and fibroblast growth factor receptor (FGFR). Shisa thus antagonizes Wnt and FGF signaling cell-autonomously, thereby promoting anterior patterning in Xenopus.
He
Xi
X
Division of Neuroscience, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
D000818:Animals; D004625:Embryo, Nonmammalian / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006257:Head / Q000196:embryology; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D008565:Membrane Proteins / Q000378:metabolism*; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism*; D011973:Receptors, LDL / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins; D014981:Xenopus / Q000196:embryology / Q000378:metabolism; D029867:Xenopus Proteins / Q000378:metabolism
D036341:Intercellular Signaling Peptides and Proteins; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D008565:Membrane Proteins; D017468:Receptors, Fibroblast Growth Factor; D011973:Receptors, LDL; D051153:Wnt Proteins; D029867:Xenopus Proteins