title: Selective attachment and release of a chemotherapeutic agent from the interior of a protein cage architecture.
abstract: The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.
authors.affiliation: Department of Microbiology, Montana State University, Lewis Hall, Bozeman, MT, USA.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Flenniken
authors.forename: Lars O
authors.initials: LO
authors.lastname: Liepold
authors.forename: Bridgid E
authors.initials: BE
authors.lastname: Crowley
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Willits
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Young
authors.forename: Trevor
authors.initials: T
authors.lastname: Douglas
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D004591:Electrophoresis, Polyacrylamide Gel; D006360:Heat-Shock Proteins / Q000737:chemistry* / Q000235:genetics; D017017:Methanococcus / Q000737:chemistry; D015202:Protein Engineering; D021122:Protein Subunits / Q000737:chemistry / Q000235:genetics
chemical_list: D000903:Antibiotics, Antineoplastic; D006360:Heat-Shock Proteins; D021122:Protein Subunits; D004317:Doxorubicin