title: Relationship between asynchronous myocardial contraction and left ventricular systolic and diastolic function--assessment using the ECG-gated polar map with 99mTc-methoxy-isobutyl isonitrile.
abstract: BACKGROUND
  To quantitate the degree of 3-dimensional asynchronous myocardial contraction, an ECG-gated polar map method was developed with (99m)Tc-methoxy-isobutyl isonitrile, and used to investigate the relationship between asynchrony and left ventricular (LV) function.
  
  
  RESULTS
  Twelve normal subjects and 38 patients with an old myocardial infarction were studied with ECG-gated single-photon emission computed tomography (SPECT). In each frame, a myocardial perfusion polar map was reconstructed and the peak contraction phase in each pixel was displayed (phase map). The degree of asynchronous contraction was assessed from the standard deviations of the peak contraction phase (SDP) on the phase map. Ejection fraction (EF), peak ejection rate (PER), 1/3EF, peak filling rate (PFR) and 1/3 filling fraction (1/3FF) were calculated by the quantitative gated SPECT software, and E/A from Doppler echocardiography. The SDP was compared with these parameters. Correlation coefficients and p values between the SDP and parameters of cardiac function were as follows: EF, r=-0.69 (p<0.001); PER, r=-0.54 (p<0.001); 1/3EF, r=-0.57 (p<0.001); PFR, r=-0.29 (p<0.05); 1/3FF, r=-0.63 (p<0.001); E/A, r=-0.11 (p=0.51).
  
  
  CONCLUSIONS
  There was a negative correlation between the SDP and LV systolic and diastolic function, which confirmed the functional significance of asynchrony on cardiac function.
authors.affiliation: Department of Cardiology, Takashima General Hospital, Shiga, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Sugihara
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Yonekura
authors.forename: Takehiro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sasaki
mesh_terms: D000368:Aged; D018780:Body Surface Potential Mapping / Q000379:methods*; D016022:Case-Control Studies; D003971:Diastole / Q000502:physiology*; D005260:Female; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D009203:Myocardial Infarction; D017256:Technetium Tc 99m Sestamibi; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis*
chemical_list: D017256:Technetium Tc 99m Sestamibi