Adjustment of the gamma dihedral angle of an oligonucleotide P3'-->N5' phosphoramidate enhances its binding affinity towards complementary strands.
Obika
Satoshi
S
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Sekiguchi
Mitsuaki
M
Somjing
Roongjang
R
Imanishi
Takeshi
T
D000577:Amides / Q000737:chemistry*; D001483:Base Sequence; D001665:Binding Sites; D006868:Hydrolysis; D008024:Ligands; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000138:chemical synthesis*; D009841:Oligonucleotides / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry*; D013696:Temperature; D013941:Thymine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D013997:Time Factors
D000577:Amides; D008024:Ligands; D009696:Nucleic Acids; D009841:Oligonucleotides; D010756:Phosphoric Acids; C011067:phosphoramidic acid; D013941:Thymine