title: Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing.
abstract: Plasmodium falciparum MSP6 is a merozoite surface antigen that shows organization and sequence homologies similar to those of MSP3. Within its C-terminus conserved region, it presents some epitopes that are cross-reactive with MSP3 and others that are not, both being targets of naturally occurring antibodies that block the P. falciparum erythrocytic cycle in cooperation with monocytes.
authors.affiliation: Bio-medical Parasitology Unit, Institute Pasteur, 28 rue du Dr Roux, 75015 Paris, France.
authors.forename: Subhash
authors.initials: S
authors.lastname: Singh
authors.forename: Soe
authors.initials: S
authors.lastname: Soe
authors.forename: Christian
authors.initials: C
authors.lastname: Roussilhon
authors.forename: Giampietro
authors.initials: G
authors.lastname: Corradin
authors.forename: Pierre
authors.initials: P
authors.lastname: Druilhe
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000953:Antigens, Protozoan / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006801:Humans; D016778:Malaria, Falciparum / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology*; D008969:Molecular Sequence Data; D009000:Monocytes / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*
chemical_list: D000906:Antibodies; D000953:Antigens, Protozoan; D000939:Epitopes; D008565:Membrane Proteins; D015800:Protozoan Proteins; C089133:merozoite surface protein 3, Plasmodium; C435213:merozoite surface protein 6, Plasmodium