title: Determinants of small solute clearance in hemodialysis.
abstract: Recent outcome trials in chronic dialysis patients raise concerns about the relationship between delivered urea Kt/V and survival. Nevertheless, measurement of delivered small solute clearance remains the most common approach to quantify therapy. The purpose of this review is to provide an overview of the numerous factors influencing small solute clearance during hemodialysis. Although the focus of the review is on the manner in which dialyzer characteristics influence small solute clearances, factors related to other aspects of the extracorporeal circuit and to the patient will also be discussed.
authors.affiliation: Center for Biomedical Engineering, University of Kentucky, Louisville, Kentucky, USA.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Huang
authors.forename: William R
authors.initials: WR
authors.lastname: Clark
authors.forename: Dayong
authors.initials: D
authors.lastname: Gao
mesh_terms: D001806:Blood Urea Nitrogen; D015314:Dialysis Solutions / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D012079:Renal Circulation; D006435:Renal Dialysis; D014508:Urea / Q000378:metabolism*
chemical_list: D015314:Dialysis Solutions; D014508:Urea