title: Identification in chromosome 8q11 of a region of homology with the g1 amplicon of the Y chromosome and functional analysis of the BEYLA gene.
abstract: The male-specific region (MSY) of the Y chromosome contains genes involved mainly in male sex determination and in spermatogenesis. The majority of genes involved in male fertility are localized in multiple copies in the long arm of the Y chromosome, within specific regions defined as "ampliconic regions." It has been suggested that these genes derived from X-linked or autosomal ancestors during evolution, providing a benefit for male fertility when transposed onto the Y chromosome. So far, the autosomal origin has been demonstrated only for two MSY genes, DAZ and CDY. In the present study we report on the identification within chromosome 8q11.2 of a region homologous to the g amplicon, containing the VCY2 (approved gene symbol BPY2), TTTY4, and TTTY17 genes. A search for ancestor genes within the 8q11.2 region allowed us to identify a gene named BEYLA and to characterize the genomic organization and the expression patterns of this gene.
authors.affiliation: Department of Biomedical Sciences, Gabriele d'Annunzio University Foundation, Chieti-Pescara, Via dei Vestini 35, 66013 Chieti, Italy. stuppia@unich.it
authors.forename: Liborio
authors.initials: L
authors.lastname: Stuppia
authors.forename: Valentina
authors.initials: V
authors.lastname: Gatta
authors.forename: Oronzo
authors.initials: O
authors.lastname: Scarciolla
authors.forename: Ivana
authors.initials: I
authors.lastname: Antonucci
authors.forename: Elisena
authors.initials: E
authors.lastname: Morizio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Calabrese
authors.forename: Giandomenico
authors.initials: G
authors.lastname: Palka
mesh_terms: D000818:Animals; D002898:Chromosomes, Human, Pair 8; D041322:Chromosomes, Human, Y; D019143:Evolution, Molecular; D015870:Gene Expression; D006801:Humans; D008297:Male; D011506:Proteins / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: C466623:BPY2 protein, human; D011506:Proteins