title: A new bactericidal lead structure for the protection of materials.
abstract: Our search for a new broad spectrum bactericide for preserving materials lead to the discovery of a highly active bicyclic amine (1) and a number of derivatives. The synthesis and biological evaluation as well as a first toxicological assessment of these compounds are described. Compound 1 shows strong bactericidal activity down to levels of below 100 ppm but unfortunately increases the number of mutations in Ames tests.
authors.affiliation: Bayer Chemicals AG, Material Protection Products, BCH-R and D, Geb. I1, 51368 Leverkusen, Germany. erasmus.vogl.ev@bayerchemicals.com
authors.forename: Erasmus
authors.initials: E
authors.lastname: Vogl
authors.forename: Rainer
authors.initials: R
authors.lastname: Bruns
authors.forename: Oliver
authors.initials: O
authors.lastname: Kretschik
authors.forename: Hermann
authors.initials: H
authors.lastname: Uhr
authors.forename: Johannes
authors.initials: J
authors.lastname: Kaulen
authors.forename: Martin
authors.initials: M
authors.lastname: Kugler
authors.forename: Peter
authors.initials: P
authors.lastname: Wachtler
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kreiss
authors.forename: Günther
authors.initials: G
authors.lastname: Eberz
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000494:pharmacology; D004202:Disinfectants / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004202:Disinfectants