title: Swietenia mahagony extract shows agonistic activity to PPAR(gamma) and gives ameliorative effects on diabetic db/db mice.
abstract: OBJECTIVE
  To search the peroxisome proliferator-activated receptor g (PPAR(gamma)) agonists from Swietenia mahagony extract (SmE) and observe the possible ameliorative effects of SmE on diabetic db/db mice.
  
  
  METHODS
  The PPAR(gamma) agonistic activity of SmE was screened by yeast-two hybrid system. The blood glucose levels of diabetic db/db mice were measured using a blood glucose level monitor and the data were statistically analyzed by NDST8.8W software.
  
  
  RESULTS
  By using the clinical drug rosiglitazone as a positive control, it was found that the PPARg agonistic activity of SmE at a concentration of 50 microg/L was approximately half that of 35.7 microg/L (0.1 micromol/L) of rosiglitazone. At the dose of 1000 mg/kg, SmE remarkably decreased the blood glucose concentration of db/db mice from (15.26+/-2.98) to (7.58+/-2.20) mmol/L, and reduced the blood glucose levels by 55.49% compared with the control group (P<0.01).
  
  
  CONCLUSIONS
  SmE shows agonistic activity to PPARg and can ameliorate the blood glucose levels of diabetic db/db mice. SmE may be thus used as a potential agent for diabetes therapy.
authors.affiliation: Drug Discovery and Design Center, State Key Lab of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Li
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Chen
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
authors.forename: Min-Li
authors.initials: ML
authors.lastname: Chen
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Wang
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Shen
authors.forename: Xu
authors.initials: X
authors.lastname: Shen
authors.forename: Hua-Liang
authors.initials: HL
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D029582:Meliaceae / Q000737:chemistry; D051379:Mice; D047495:PPAR gamma / Q000819:agonists*; D010946:Plants, Medicinal / Q000737:chemistry; D012639:Seeds
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D047495:PPAR gamma