Influence of angiotensin-converting enzyme I/D gene polymorphism on the right ventricular myocardial performance index in patients with a first acute anterior myocardial infarction.
BACKGROUND
The genetic influence on the myocardial performance index is uncertain, so the aim of the present study was to determine the effects of polymorphism of the angiotensin-converting enzyme (ACE) gene on the right ventricular myocardial performance index (RVMPI) after a first acute anterior myocardial infarction (MI).


RESULTS
The subjects were 116 patients with a first acute anterior MI. Based on the polymorphism of the ACE gene, they were classified into 3 groups: deletion/deletion (DD) genotype (group 1, n=45), insertion/deletion (ID) genotype (group 2, n=58), insertion/insertion (II) genotype (group 3, n=13). Echocardiograms were used to determine the RVMPI, left ventricular myocardial performance index (LVMPI), tricuspid E/A, tricuspid deceleration time and the left ventricular diameter diastolic and diameter systolic (LVDd and LVDs). RVMPI and LVMPI were significantly higher in the ACE DD group. Tricuspid E/A, DT, LVDd and LVDs showed no differences among the 3 groups.


CONCLUSIONS
The ID polymorphism of the ACE gene may affect RVMPI and LVMPI after a first acute anterior MI.
Ozturk
Onder
O
Department of Cardiology, Dicle University School of Medicine, Diyarbakir, Turkey. droozturk21@yahoo.com
Ulgen
Mehmet S
MS
Tekes
Selahattin
S
Ozturk
Unal
U
Toprak
Nizamettin
N
D000368:Aged; D004252:DNA Mutational Analysis; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D009203:Myocardial Infarction / Q000235:genetics* / Q000503:physiopathology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017384:Sequence Deletion; D018487:Ventricular Dysfunction, Left / Q000235:genetics; D018497:Ventricular Dysfunction, Right / Q000235:genetics*
D007703:Peptidyl-Dipeptidase A