Kinetic characteristics of biochemical parameters during consupren therapy after allogenic transplantation of the kidney.
Changes in biochemical and common clinical parameters of the blood were detected in patients treated with consupren (cyclosporin) as the main immunosuppressant after allogenic transplantation of the kidney. Kinetic model for evaluation of treatment adequacy was based on therapeutic drug monitoring and monitoring of blood biochemistry in recipients of the primary kidney transplant. The k1, t1/2, C0, clearance (for hemoglobin), conditioned volume of distribution (for cyclosporin) of processes of biochemical parameters (toxicity markers) stabilization within the framework of a single-part kinetic model were determined.
Denisova
N A
NA
Russian University of Peoples' Friendship, Moscow.
Pletneva
T V
TV
Baikova
V N
VN
Berezov
T T
TT
D000293:Adolescent; D000328:Adult; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000502:physiology*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous; D014508:Urea / Q000097:blood
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D014508:Urea; D003404:Creatinine