title: Effect of MK-801 on sensitivity of the respiratory system to oxygen deficiency and organisms resistance to hypoxia.
abstract: We studied changes in organism's sensitivity and resistance to hypoxic hypoxia under conditions of NMDA receptor blockade with MK-801. Breathing hypoxic gas mixture after administration of MK-801 sharply decreased the mean blood pressure in the systemic circulation and slightly improved lung ventilation in animals. Respiratory arrest was observed in 40% animals. NMDA receptor blockade decreased organism's sensitivity and resistance to hypoxic hypoxia.
authors.affiliation: Laboratory for Pathophysiology of Respiration, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. inspiration@mtu-net.ru
authors.forename: I A
authors.initials: IA
authors.lastname: Tarakanov
authors.forename: A
authors.initials: A
authors.lastname: Dymetska
authors.forename: N N
authors.initials: NN
authors.lastname: Tarasova
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000502:physiology; D012137:Respiratory System / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate