[Molecular mechanism of age-related osteoporosis].
Bone loss by ageing has been investigated from standpoints of systemic abnormality and some deficiency in osteoblastic bone formation. This seminar summarizes the involvements of a key molecule of adipocytic differentiation PPAR-gamma, essential IGF-I signaling molecules IRS-1 and IRS-2, and an anti-aging gene klotho in the pathophysiology of age-related osteoporosis.
Kawaguchi
Hiroshi
H
Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo.
D000368:Aged; D000375:Aging; D000818:Animals; D001862:Bone Resorption; D004967:Estrogens / Q000502:physiology; D005260:Female; D005966:Glucuronidase; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D000090265:Klotho Proteins; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D010012:Osteogenesis / Q000502:physiology*; D010024:Osteoporosis / Q000235:genetics* / Q000503:physiopathology*; D047495:PPAR gamma / Q000502:physiology; D015398:Signal Transduction
D004967:Estrogens; D008565:Membrane Proteins; D047495:PPAR gamma; D007334:Insulin-Like Growth Factor I; D005966:Glucuronidase; D000090265:Klotho Proteins