Resistance of native and circulating modified low-density lipoproteins in human blood to association.
The resistance of native and circulating modified low-density lipoproteins from human blood to spontaneous and polyethylene glycol-induced association was studied by recording light transmission fluctuations. Circulating modified low-density lipoproteins were less resistant to association than native low-density lipoproteins. Polyethylene glycol-induced association of low-density lipoproteins was irreversible. Our results suggest that atherogenic activity of circulating modified low-density lipoproteins is associated with their increased predisposition to irreversible association.
Suprun
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Laboratory for Mechanisms of Atherogenesis, Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Russian Ministry of Health. inat@cardio.ru
Mel'nichenko
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Sobenin
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Panasenko
O M
OM
Orekhov
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AN
D001161:Arteriosclerosis / Q000097:blood; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D066298:In Vitro Techniques; D008027:Light; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry* / Q000187:drug effects; D011092:Polyethylene Glycols / Q000494:pharmacology
D008077:Lipoproteins, LDL; D011092:Polyethylene Glycols