title: Bioactive constituents of Artemisia monosperma.
abstract: During a study on the chemistry and biological activity of Kuwaiti plants, new metabolites including 4,6-dihydroxy-3-[3'-methyl-2'-butenyl]-5-[4''-hydroxy-3''-methyl-2''-butenyl]-cinnamic acid (1), the 3R,8R stereoisomer of the C17 polyacetylene dehydrofalcarindiol (2) and a C10 polyacetylene glucoside (3) were characterised by spectroscopic means. Additionally, the previously characterised natural products 1,3R,8R-trihydroxydec-9-en-4,6-yne (4), spathulenol (5) and eriodyctiol-7-methyl ether (6) were also isolated. Compounds 2, 3, and 4 were evaluated for their ability to inhibit the enzyme 12-lipoxygenase and 3 and 4 showed moderate activity at 30 microg/ml. Compound 2 was evaluated against a panel of colorectal and breast cancer cell lines and IC50 values ranged from 5.8 to 37.6 microg/ml. Against a panel of fast-growing mycobacteria and a standard ATCC strain of Staphylococcus aureus, compound 6 exhibited minimum inhibitory concentrations in the range of 64-128 microg/ml.
authors.affiliation: Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Stavri
authors.forename: Christopher H J
authors.initials: CH
authors.lastname: Ford
authors.forename: Franz
authors.initials: F
authors.lastname: Bucar
authors.forename: Bernhard
authors.initials: B
authors.lastname: Streit
authors.forename: Michael L
authors.initials: ML
authors.lastname: Hall
authors.forename: R Thomas
authors.initials: RT
authors.lastname: Williamson
authors.forename: K T
authors.initials: KT
authors.lastname: Mathew
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D019306:Artemisia / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D016859:Lipoxygenase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts