Defective phagocytosis in Anaplasma phagocytophilum-infected neutrophils.
Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls (P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.
Garyu
Justin W A
JW
Department of Pathology, Division of Medical Microbiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 624, Baltimore, MD 21205, USA.
Choi
Kyoung-seong
KS
Grab
Dennis J
DJ
Dumler
J Stephen
JS
D041081:Anaplasma phagocytophilum / Q000472:pathogenicity*; D002176:Candida albicans; D006801:Humans; D009504:Neutrophils / Q000382:microbiology / Q000502:physiology*; D010587:Phagocytosis / Q000502:physiology*