[Action site of bisphenol A as metabolic disruptor lies in the tryptophan-nicotinamide conversion pathway].
We have reported that the administration of bisphenol A to rats reduces the conversion ratio of tryptophan to nicotinamide. In the present paper, we show that bisphenol A, a monomer of polycarbonate plastics, inhibits the enzyme activity of kynurenine 3-hydroxylase. Namely, the conversion ratio of tryptophan to nicotinamide is reduced through the inhibition of kynurenine 3-hydroxylase activity by bisphenol A.
Fukuwatari
Tsutomu
T
Laboratory of Food Science, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, 2500 Hassaka-cho, Hikone 522-8533, Japan.
Suzuura
Chie
C
Sasaki
Ryuzo
R
Shibata
Katsumi
K
D000395:Air Pollutants, Occupational / Q000494:pharmacology*; D000818:Animals; D001559:Benzhydryl Compounds; D050601:Kynurenine 3-Monooxygenase; D008297:Male; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D009536:Niacinamide / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013831:Thiamine / Q000652:urine; D014364:Tryptophan / Q000378:metabolism*; D000098826:Bisphenol A Compounds
D000395:Air Pollutants, Occupational; D001559:Benzhydryl Compounds; D050601:Kynurenine 3-Monooxygenase; D006899:Mixed Function Oxygenases; D009536:Niacinamide; D010636:Phenols; D013831:Thiamine; D014364:Tryptophan; C006780:bisphenol A; D000098826:Bisphenol A Compounds