Effects of phospholipids on antiganglioside antibody reactivity in GBS.
Serum antibody activities to mixtures of a ganglioside and various phospholipids were compared with those to a ganglioside alone in 30 anti-GM1 IgG-positive GBS patients and 30 anti-GQ1b IgG-positive Miller Fisher syndrome (MFS) patients. Anti-GM1-positive sera had higher antibody reactivities against a mixture of GM1 and several phospholipids including PA, PI and PS, than against GM1 alone. In contrast, in case of anti-GQ1b antibody, no phospholipid provided significant enhancement. Sphingomyelin provided decrease of the activity for both anti-GM1 and anti-GQ1b IgG. The effects of phospholipids must be considered to determine the pathogenetic role of antiganglioside antibodies in GBS and MFS.
Hirakawa
Minako
M
Department of Neurology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.
Morita
Daiji
D
Tsuji
Shoji
S
Kusunoki
Susumu
S
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D001666:Binding Sites, Antibody / Q000187:drug effects; D002308:Cardiolipins / Q000494:pharmacology; D005677:G(M1) Ganglioside / Q000276:immunology* / Q000378:metabolism*; D005732:Gangliosides / Q000276:immunology* / Q000378:metabolism*; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007075:Immunoglobulin M / Q000378:metabolism; D008244:Lysophosphatidylcholines / Q000494:pharmacology; D008246:Lysophospholipids / Q000494:pharmacology; D010712:Phosphatidic Acids / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000494:pharmacology; D010718:Phosphatidylserines / Q000494:pharmacology; D010743:Phospholipids / Q000494:pharmacology*; D013109:Sphingomyelins / Q000276:immunology / Q000378:metabolism
D000276:Adjuvants, Immunologic; D002308:Cardiolipins; D005732:Gangliosides; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008244:Lysophosphatidylcholines; D008246:Lysophospholipids; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D010716:Phosphatidylinositols; D010718:Phosphatidylserines; D010743:Phospholipids; D013109:Sphingomyelins; C008301:lysophosphatidylethanolamine; D005677:G(M1) Ganglioside; C039129:GQ1b ganglioside