title: Daphmanidins C and D, novel pentacyclic alkaloids from Daphniphyllum teijsmanii.
abstract: [structure: see text] Two novel alkaloids with an unprecedented fused-pentacyclic skeleton, daphmanidins C (1) and D (2), have been isolated from the leaves of Daphniphyllum teijsmanii, and the structures were elucidated on the basis of spectroscopic data. The relative stereochemistry of 1 and 2 was assigned by combination of NOESY correlations and a simulation analysis. Daphmanidin C (1) elevated activity of NGF biosynthesis.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Nozomi
authors.initials: N
authors.lastname: Ishioka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takatsu
authors.forename: Takakazu
authors.initials: T
authors.lastname: Shinzato
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Obara
authors.forename: Norimichi
authors.initials: N
authors.lastname: Nakahata
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009414:Nerve Growth Factors / Q000096:biosynthesis; D018515:Plant Leaves / Q000737:chemistry; D010944:Plants / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013268:Stimulation, Chemical
chemical_list: D000470:Alkaloids; D007202:Indicators and Reagents; D009414:Nerve Growth Factors; D011083:Polycyclic Compounds; D013141:Spiro Compounds; C510265:daphmanidin C; C510264:daphmanidin D