title: Decrease in circulating anti-angiogenic factors (angiostatin and endostatin) after surgical removal of primary colorectal carcinoma coincides with increased metabolic activity of liver metastases.
abstract: Removal of a primary colorectal tumor resulted in an increase in metabolic activity in its liver metastasis. Concomitantly, levels of angiostatin and endostatin in urine and plasma, respectively, dropped. This finding indicates that the primary tumor suppressed angiogenesis in its distant metastasis, and that removal of the primary lesion caused a flare-up in vessel neoformation and, thus, enhanced metabolic activity in its liver metastasis.
authors.affiliation: Department of Pathology 437, University Medical Center, PO Box 9101, Nijmegen 6500 HB, The Netherlands. c.peeters@pathol.umcn.nl
authors.forename: Charlotte F J M
authors.initials: CF
authors.lastname: Peeters
authors.forename: Lioe-Fee
authors.initials: LF
authors.lastname: de Geus
authors.forename: Johan R
authors.initials: JR
authors.lastname: Westphal
authors.forename: Robert M W
authors.initials: RM
authors.lastname: de Waal
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: Ruiter
authors.forename: Theo
authors.initials: T
authors.lastname: Wobbes
authors.forename: Wim J G
authors.initials: WJ
authors.lastname: Oyen
authors.forename: Theo J
authors.initials: TJ
authors.lastname: Ruers
mesh_terms: D000368:Aged; D043168:Angiostatins / Q000652:urine*; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000601:surgery*; D043169:Endostatins / Q000097:blood*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000556:secondary*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D043169:Endostatins; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D043168:Angiostatins