Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
Recent advances have shown the crucial role of histone-modifying enzymes in controlling gene activation and repression. This led to the 'histone code' hypothesis, which proposes that combinations of histone modifications work in concert to affect specific gene expression. Mounting evidence suggests that the class II transactivator modulates promoter accessibility by coordinating the recruitment of chromatin modifiers in a time-dependent fashion. MHC-II expression is exquisitely controlled by these highly specific, coordinated and dynamic interactions at the promoter.
Zika
Eleni
E
Lineberger Comprehensive Cancer Center, CB#7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Ting
Jenny P-Y
JP
D000818:Animals; D042002:Chromatin Assembly and Disassembly / Q000235:genetics / Q000276:immunology; D044127:Epigenesis, Genetic / Q000276:immunology; D005802:Genes, MHC Class II / Q000235:genetics* / Q000276:immunology; D006657:Histones / Q000276:immunology*; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics* / Q000276:immunology; D011401:Promoter Regions, Genetic / Q000235:genetics / Q000276:immunology; D015534:Trans-Activators / Q000235:genetics* / Q000276:immunology
D006657:Histones; C083728:MHC class II transactivator protein; D009687:Nuclear Proteins; D015534:Trans-Activators