Genetic control of dopaminergic neuron differentiation.
The mesencephalic dopaminergic (mesDA) system controls movement and emotional behaviour, and its degeneration causes Parkinson's disease and other psychiatric disorders. Recent findings are leading to better understanding of the genetic control of generation and functioning of the mesDA system. This advancement could disclose new perspectives for therapeutic approaches of mesDA-related disorders.
Simeone
Antonio
A
MRC Centre for Developmental Neurobiology, 4th Floor, New Hunt's House, Guy's Campus, King's College London, London Bridge, London SE1 1UL, UK. antonio.simeone@kcl.ac.uk
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D002470:Cell Survival / Q000235:genetics; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D008636:Mesencephalon / Q000166:cytology; D008954:Models, Biological; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology
D004298:Dopamine