title: The use of levonorgestrel-releasing intrauterine system for treatment of menorrhagia in women with inherited bleeding disorders.
abstract: BACKGROUND
  The levonorgestrel-releasing intrauterine system (LNG-IUS) is used commonly by gynaecologists as a contraceptive and to treat menorrhagia. However, its efficacy has not been examined in women with inherited bleeding disorders.
  
  
  METHODS
  A prospective pilot study.
  
  
  METHODS
  A teaching hospital in north London with a designated haemophilia centre.
  
  
  METHODS
  Female patients with a known inherited bleeding disorder.
  
  
  METHODS
  Sixteen women with subjective and objective menorrhagia caused by inherited bleeding disorders (13 von Willebrand's Disease, two factor XI deficiency and one Hermansky-Pudlak syndrome), who had previously undergone unsuccessful medical treatment were followed up for nine months after LNG-IUS insertion. Bleeding was measured by pictorial chart and haemoglobin concentration.
  
  
  RESULTS
  All women reported that their periods were improved, pictorial chart scores were lower and 56% became amenorrhoeic. None reported side effects.
  
  
  CONCLUSIONS
  The LNG-IUS is well tolerated and effective and improves quality of life.
authors.affiliation: Department of Obstetrics and Gynaecology, Royal Free Hospital, London, UK.
authors.forename: C E C
authors.initials: CE
authors.lastname: Kingman
authors.forename: R A
authors.initials: RA
authors.lastname: Kadir
authors.forename: C A
authors.initials: CA
authors.lastname: Lee
authors.forename: D L
authors.initials: DL
authors.lastname: Economides
mesh_terms: D000293:Adolescent; D000328:Adult; D025861:Blood Coagulation Disorders, Inherited / Q000150:complications*; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel / Q000008:administration & dosage*; D008595:Menorrhagia / Q000188:drug therapy* / Q000235:genetics; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies
chemical_list: D003271:Contraceptive Agents, Female; D016912:Levonorgestrel