title: Reductions in levels of bacterial superantigens/cannabinoids by plasma exchange in a patient with severe toxic shock syndrome.
abstract: Toxic shock syndrome is a rare but potentially fatal toxin-mediated febrile illness. We report a case of toxic shock syndrome complicated by life-threatening organ dysfunction with high toxin-1 and staphylococcus enterotoxin type A levels that were successfully reduced by early introduction of plasma exchanges. The report shows the time course of the concentrations of anandamide and 2-arachidonyl glyceride and confirms that early introduction of plasma exchange can result in a rapid reduction of circulating toxins and mediators in the treatment of life-threatening multiple organ dysfunction.
authors.affiliation: Department of Anesthesiology, Sapporo, Hokkaido, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kohro
authors.forename: H
authors.initials: H
authors.lastname: Imaizumi
authors.forename: M
authors.initials: M
authors.lastname: Yamakage
authors.forename: Y
authors.initials: Y
authors.lastname: Masuda
authors.forename: A
authors.initials: A
authors.lastname: Namiki
authors.forename: Y
authors.initials: Y
authors.lastname: Asai
mesh_terms: D000293:Adolescent; D001095:Arachidonic Acids / Q000097:blood; D001427:Bacterial Toxins / Q000097:blood; D063385:Cannabinoid Receptor Modulators / Q000097:blood*; D004075:Diglycerides / Q000097:blood; D063388:Endocannabinoids; D004768:Enterotoxins / Q000097:blood; D006801:Humans; D008297:Male; D010951:Plasma Exchange; D053284:Polyunsaturated Alkamides; D012772:Shock, Septic / Q000097:blood / Q000382:microbiology / Q000628:therapy*; D013203:Staphylococcal Infections / Q000097:blood / Q000628:therapy; D013211:Staphylococcus aureus / Q000276:immunology; D018089:Superantigens / Q000097:blood*
chemical_list: D001095:Arachidonic Acids; D001427:Bacterial Toxins; D063385:Cannabinoid Receptor Modulators; D004075:Diglycerides; D063388:Endocannabinoids; D004768:Enterotoxins; D053284:Polyunsaturated Alkamides; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; C026066:enterotoxin A, Staphylococcal; C035561:diarachidonyl diglyceride; C078814:anandamide