title: Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers.
abstract: An association between the DRD2 Taq1A (C32806T) polymorphism and social alcohol consumption in the opposite direction to that reported for alcoholism has recently been reported in a male Finnish sample. We attempted to replicate these findings in two independent samples, and extend on previous work by including female participants. The DRD2 A1 allele was significantly associated with reduced alcohol consumption in sample one (P=0.004) and sample two (P=0.015). In sample two there was a significant genotype x sex interaction (P=0.016), with the association of the A1 allele and reduced alcohol consumption significant in men only. This interaction was marginally significant (P=0.042) in a meta-analysis of combined data from both samples, and the main effect of genotype highly significant (P<0.001). Age at time of data collection and cigarette consumption were entered as covariates in all analyses. These results replicate recent previous findings and suggest a possibility that this association may exist in men only, or be stronger in men.
authors.affiliation: Cancer Research UK General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Oxford, UK. marcus.munafo@clinpharm.ox.ac.uk
authors.forename: M R
authors.initials: MR
authors.lastname: Munafò
authors.forename: E C
authors.initials: EC
authors.lastname: Johnstone
authors.forename: K I
authors.initials: KI
authors.lastname: Welsh
authors.forename: R T
authors.initials: RT
authors.lastname: Walton
mesh_terms: D000328:Adult; D000375:Aging / Q000523:psychology; D000428:Alcohol Drinking / Q000235:genetics* / Q000523:psychology; D015331:Cohort Studies; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D017931:DNA Primers; D017448:Receptors, Dopamine D2; D004247:DNA