title: Telomeres and telomerase: their mechanisms of action and the effects of altering their functions.
abstract: The molecular features of telomeres and telomerase are conserved among most eukaryotes. How telomerase and telomeres function and how they interact to promote the chromosome-stabilizing properties of telomeres are discussed here.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-2200, USA. telmor@itsa.ucsf.edu
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Blackburn
mesh_terms: D017209:Apoptosis; D002869:Chromosome Aberrations; D004268:DNA-Binding Proteins; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D019098:Telomerase / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D016615:Telomere / Q000235:genetics / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D019098:Telomerase