Study of mutagenic activity of dioxidine by the polyorgan micronuclear method.
Antibacterial preparation dioxidine administered four times in doses of 10, 100, and 300 mg/kg increased the incidence of micronucleated cells in the bone marrow, lungs, and large intestine of mice. Bone marrow cells were most sensitive, while cells of the lungs and large intestine exhibited lower sensitivity to the cytogenetic effect of dioxidine.
Sycheva
L P
LP
Laboratory of Genetic Monitoring, A. N. Sysin Institute of Human Ecology and Environmental Hygiene, Russian Academy of Medical Sciences, Moscow. lpsycheva@rambler.ru
Kovalenko
M A
MA
Sheremeteva
S M
SM
Durnev
A D
AD
Zhurkov
V S
VS
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000648:ultrastructure; D004847:Epithelial Cells / Q000187:drug effects / Q000648:ultrastructure; D007420:Intestine, Large / Q000187:drug effects / Q000648:ultrastructure; D008168:Lung / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015162:Micronucleus Tests / Q000379:methods*; D009153:Mutagens / Q000633:toxicity*; D011810:Quinoxalines / Q000633:toxicity*
D009153:Mutagens; D011810:Quinoxalines; C001077:dioxidine