title: Periodontal health improves systemic inflammatory and haemostatic status in subjects with coronary heart disease.
abstract: OBJECTIVE
  A relationship between poor oral health and coronary heart disease (CHD) and systemic inflammatory and haemostatic factors has been recently documented in an Italian population. The present study was performed to assess whether intensive dental care may produce a periodontal improvement along with a change in systemic inflammatory and haemostatic factors.
  
  
  METHODS
  The study population consisted of 18 males aged 40-65 years with proven CHD and elevated values of systemic inflammatory and haemostatic factors. A detailed description of their oral status was given by using two different dental indices (clinical periodontal sum score and clinical and radiographic sum score). Blood samples were taken for measurement of the following systemic markers of inflammation [(C-reactive protein (CRP), leucocytes, fibrinogen)] and haemostatic factors [(von Willebrand factor, fibrin D-dimer and oxidized-low density lipoprotein (Ox-LDL)]. All parameters were determined in each subject at baseline, after 4 months as a control and 3 months after an intensive protocol of scaling and root planing. anova for repeated measures was used for the statistical analysis.
  
  
  RESULTS
  No statistical difference was found between values at baseline and at the 4-month-control. All oral indexes showed a significant decrease (p< .01) 3 months after periodontal treatment. All systemic inflammatory indexes decreased but only the decrease in CRP reached statistical significance (p< .05). A significant decrease (p< .01) was also found as regards Ox-LDL among haemostatic factors.
  
  
  CONCLUSIONS
  Preliminary results from the present study suggest an association between poor oral status and CHD, and provide evidence that the improvement of periodontal status may influence the systemic inflammatory and haemostatic situation.
authors.affiliation: Department of Oral Science, University of Bologna, Bologna, Italy. montebu@alma.unibo.it
authors.forename: L
authors.initials: L
authors.lastname: Montebugnoli
authors.forename: D
authors.initials: D
authors.lastname: Servidio
authors.forename: R A
authors.initials: RA
authors.lastname: Miaton
authors.forename: C
authors.initials: C
authors.lastname: Prati
authors.forename: P
authors.initials: P
authors.lastname: Tricoci
authors.forename: C
authors.initials: C
authors.lastname: Melloni
authors.forename: G
authors.initials: G
authors.lastname: Melandri
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002097:C-Reactive Protein / Q000032:analysis; D003327:Coronary Disease / Q000150:complications*; D003729:Dental Care; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000150:complications*; D007958:Leukocyte Count; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009909:Oral Health; D010510:Periodontal Diseases / Q000150:complications* / Q000628:therapy; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D014841:von Willebrand Factor; D005340:Fibrinogen; D002097:C-Reactive Protein