Quantitative structure-retention relationships of benzoylphenylureas on polystyrene-octadecene-encapsulated zirconia stationary phase in reversed-phase high performance liquid chromatography.
Quantitative Structure-Retention Relationships of benzoylphenylureas and similar compounds have been studied on a new type of stationary phase (polystyrene-octadecene-encapsulated zirconia) in reversed-phase high performance liquid chromatography. Using stepwise regression analysis, the relationships between the structural descriptors of the compound and its chromatographic retention were examined. It was confirmed that the retention of the dihalogenobenzoylphenylureas is mainly governed by the dipole moment (DM), the calculated molar refractivity (CMR), and the hydrophobicity parameter (C log P) of the compounds. The predicting equations for the 18 dihalogenobenzoylphenylureas and similar compounds were also established; there is a good agreement between the observed k values and the predicted k values. In addition, a typical ODS (Kromasil-C18-SiO2) was compared with C18-PS-ZrO2. The results showed that there were some differences between the two stationary phase for the separation of the compounds investigated, which are certainly related to surface characteristics of the two different supports.
Xia
Yan
Y
Department of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
Guo
Yunfeng
Y
Wang
Hui
H
Wang
Qian
Q
Zuo
Yumin
Y