title: Lepidium meyenii (Maca) reduces spermatogenic damage induced by a single dose of malathion in mice.
abstract: OBJECTIVE
  To observe the effect of the aqueous extract of hypocotyls of the plant Lepidium meyenii (Maca) on spermatogenic damage induced by the organophosphate insecticide malathion in mice.
  
  
  METHODS
  Mice were treated with 80 mg/kg of malathion in the presence or absence of an aqueous extract of Maca, which was orally administered 7, 14 or 21 days after injection of the malathion. Stages of the seminiferous epithelium were assessed by transillumination on days 0, 7, 14 and 21.
  
  
  RESULTS
  The administration of Maca increased significantly the length of stage VIII on days 7, 14 and 21 of treatment compared with the controls. An increase in the length of stage IX occurred on day 14 of treatment. Malathion affected spermatogenesis by reducing the lengths of stage IX on day 7, stages VII and IX-XI on day 14 and a recovery of stages IX-XII on day 21. The magnitude of alteration in the length of stage IX produced by malathion was significantly reduced by Maca on days 7 and 14. The length of stage VIII was increased when Maca was administered to mice treated with malathion. Assessment of the relative length of stages of the seminiferous epithelium showed that Maca treatment resulted in rapid recovery of the effect of malathion.
  
  
  CONCLUSIONS
  Maca enhances spermatogenesis following spermatogenic damage caused by the organophosphorous pesticide.
authors.affiliation: Faculty of Medicine, University of Chile, Independencia 1027 P.O. Box 70061, Santiago 7, Chile. ebustos@med.uchile.cl
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bustos-Obregon
authors.forename: Sandra
authors.initials: S
authors.lastname: Yucra
authors.forename: Gustavo F
authors.initials: GF
authors.lastname: Gonzales
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D018546:Hypocotyl; D029686:Lepidium; D008294:Malathion / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D013091:Spermatogenesis / Q000187:drug effects*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts; D008294:Malathion