Anti-brain but not celiac disease antibodies in Landau-Kleffner syndrome and related epilepsies.
The Landau-Kleffner syndrome, the continuous spikes-waves during slow sleep syndrome and the benign epilepsy of childhood with rolandic spikes are rare childhood epilepsies with unknown etiology. Improvement in patients treated with immunoglobulin suggests an involvement of the immune system. We provide immunohistochemical evidence of autoantibodies against rat brain auditory cortex, brainstem and cerebellum, in children suffering with one or more of these syndromes. Only 1/14 patient was celiac.
Boscolo
S
S
BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Via L. Giorgieri 10-34127, Trieste, Italy.
Baldas
V
V
Gobbi
G
G
Giordano
L
L
Cioni
G
G
Not
T
T
Ventura
A
A
Tongiorgi
E
E
D000293:Adolescent; D000818:Animals; D001323:Autoantibodies / Q000032:analysis / Q000096:biosynthesis*; D001923:Brain Chemistry / Q000276:immunology*; D001933:Brain Stem / Q000276:immunology; D002446:Celiac Disease / Q000276:immunology; D002531:Cerebellum / Q000276:immunology; D002540:Cerebral Cortex / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000276:immunology; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000276:immunology*; D011689:Purkinje Cells / Q000276:immunology; D051381:Rats
D001323:Autoantibodies