[p53 gene codon 72 polymorphism and susceptibility to keloid in Chinese population].
OBJECTIVE
To investigate the relationship between p53 codon 72 polymorphism and susceptibility to keloid.


METHODS
The p53 genotypes were detected by polymerase chain reaction-reverse dot blot (PCR-RDB) and DNA direct sequencing among 15 healthy controls and 15 patients with keloid.


RESULTS
The frequency of the Pro allele (P = 0.035) and Pro/Pro genotype (P = 0.030) in patients was significantly higher than that in the controls. There was no significant difference in the frequency of Pro/Arg and Arg/Arg genotypes between patients and controls.


CONCLUSIONS
The p53 gene codon 72 polymorphism may play a role in susceptibility to keloid.
Zhuo
Yang
Y
Department of Plastic Surgery, Nanfang Hospital, Southern Medical University (the First Military Medical University), Guangzhou Guangdong 510515, PR China.
Gao
Jianhua
J
Luo
Shenqiu
S
Zeng
Weisen
W
Hu
Zhiqi
Z
Lu
Feng
F
Zhao
Yongzhong
Y
D000483:Alleles; D001120:Arginine / Q000235:genetics; D044466:Asian People / Q000235:genetics; D002681:China; D003062:Codon / Q000235:genetics; D005091:Exons / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007627:Keloid / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D011392:Proline / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D003062:Codon; D016159:Tumor Suppressor Protein p53; D001120:Arginine; D011392:Proline