[The opsoclonus-myoclonus syndrome].
The opsoclonus-myoclonus syndrome (OMS) was diagnosed in nine patients, two men and seven women, varying in age from 34 to 65 years. In two cases the findings indicated a post-infectious form, in three cases there was a malignancy, in one case there was a connection with the use of medication and in three cases the cause was unknown. OMS is a rare neurological disorder with symptoms of rapid, involuntary saccadic eye movements (opsoclonus) and sudden involuntary muscle contractions (myoclonus). It has been associated with infections, malignancies, intoxications and metabolic disorders. In 50% of the cases no cause can be identified. There is evidence for dysfunction ofbrainstem and cerebellar pathways and in many cases an (auto-)immune process is implied. Once the diagnosis has been established, screening for occult malignancy is indicated. The prognosis of idiopathic and post-infectious OMS is generally good and the treatment is mainly supportive.
de Brabander
C
C
Afd. Neurologie, Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden. c.de_brabander@lumc.nl
Hoff
J I
JI
Tijssen
C C
CC
Lammers
G J
GJ
Verschuuren
J J G M
JJ
D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000175:diagnosis; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D011379:Prognosis; D016896:Treatment Outcome