[Study on the antioxidative effect of Safflor Yellow].
OBJECTIVE
To observe the antioxidative effect of Safflor Yellow (SY).


METHODS
Hydroxyl radical scavenge effect of SY was tested with 1,10-phenanthroline-Fe2+ oxidative assay. Lipid peroxidation of mouse liver suspension was measured with thiobarbituric acid colorimetry technique. Hemocytocatheresis was determined with colorimetry.


RESULTS
Hydroxyl radical could be scavenged by 1.39 to 3.42 g x L(-1) SY dose dependently. Mouse liver suspension peroxidation was inhibited by 77.8 to 776.1 mg x L(-1) SY dosage dependently. Hemocytocatheresis was attenuated by 37.1 to 297.1 mg x L(-1) SY dose dependently.


CONCLUSIONS
SY is an antioxidative part of Carthamus tinctorius.
Jin
Ming
M
Department of Pharmacology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing 100029, China. jinzang@public3.bta.net.cn
Li
Jin-rong
JR
Wu
Wei
W
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D031187:Carthamus tinctorius / Q000737:chemistry; D002599:Chalcone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D035264:Flowers / Q000737:chemistry; D016166:Free Radical Scavengers / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits
D000975:Antioxidants; D016166:Free Radical Scavengers; C076422:safflower yellow; D017665:Hydroxyl Radical; D002599:Chalcone