title: Screening for antiproliferative activity of six southern Brazilian species of Hypericum.
abstract: The crude methanolic extracts of six species of Hypericum growing in southern Brazil (Hypericum caprifoliatum Cham. & Schlecht., H. carinatum Griseb., H. connatum Lam., H. myrianthum Cham. & Schlecht., H. polyanthemum Klotzsch ex Reichardt and H. ternum A. St. Hil.) were screened for their antiproliferative activity against two cell lines (HT-29 human colon carcinoma cells and H-460 non-small cell lung carcinoma). The most active crude extracts were those from H. caprifoliatum, H. myrianthum and, to a lesser extent, from H. connatum. All plants were submitted to fractionation with solvents in increasing polarity and re-assayed for the two cell lines used previously, as well as U-373 human malignant glioma cells. The most active fractions were the hexane fractions obtained from H. caprifoliatum, H. myrianthum and H. ternum.
authors.affiliation: Programa de Pós Graduação em Ciências Farmacêuticas, UFRGS, Av. Ipiranga, 2752, 90610-000 Porto Alegre, RS, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Ferraz
authors.forename: D H
authors.initials: DH
authors.lastname: Faria
authors.forename: M N
authors.initials: MN
authors.lastname: Benneti
authors.forename: A Brondani
authors.initials: AB
authors.lastname: da Rocha
authors.forename: G
authors.initials: G
authors.lastname: Schwartsmann
authors.forename: A
authors.initials: A
authors.lastname: Henriques
authors.forename: G L
authors.initials: GL
authors.lastname: von Poser
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001938:Brazil; D045744:Cell Line, Tumor / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D019073:HT29 Cells / Q000187:drug effects; D006801:Humans; D020902:Hypericum; D008519:Medicine, Traditional; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts