Diagnosis of renal allograft rejection and acute tubular necrosis by 99mTc-mononuclear leukocyte imaging.
One hundred kidney transplant recipients were evaluated on the first and fifth days after transplantation by Tc-99m mononuclear cell scintigraphy. We have developed a quantitative method to diagnose rejection and acute tubular necrosis (ATN) by comparing regions of interest drawn on allograft scintigraphs at different times after endovenous administration of the labeled cells. We suggest that the use of Tc-99m-WBC may be useful for the early diagnosis of rejection and the differential diagnosis of ATN.
Lopes de Souza
S A
SA
Departamento de Radiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Barbosa da Fonseca
L M
LM
Torres Gonçalves
R
R
Salomão Pontes
D
D
Holzer
T J
TJ
Proença Martins
F P
FP
Gutfilen
B
B
D000208:Acute Disease; D001692:Biological Transport; D005260:Female; D006084:Graft Rejection / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D016030:Kidney Transplantation / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology*; D019520:Living Donors; D008297:Male; D009336:Necrosis; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D013667:Technetium / Q000493:pharmacokinetics; D014019:Tissue Donors; D014184:Transplantation, Homologous / Q000473:pathology
D013667:Technetium