title: Production of [17F]CH3F (t1/2=65 s), an improved PET tracer for rCBF measurement.
abstract: Production of 17F (t1/2=65 s) in the form of [17F] F2 has been achieved using both the 20Ne(p,alpha)17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH3F (>60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi /microA for protons and 44 mCi/microA for deuterons have been measured for [17F]F2.
authors.affiliation: Medical Physics, University of Wisconsin, 1500 N. Highland Ave. T-121 Waisman Center, Madison, WI 53705, USA. tebarnhart@wisc.edu
authors.forename: T E
authors.initials: TE
authors.lastname: Barnhart
authors.forename: A K
authors.initials: AK
authors.lastname: Converse
authors.forename: K A
authors.initials: KA
authors.lastname: Dabbs
authors.forename: M J
authors.initials: MJ
authors.lastname: Schueller
authors.forename: C K
authors.initials: CK
authors.lastname: Stone
authors.forename: R J
authors.initials: RJ
authors.lastname: Nickles
authors.forename: A D
authors.initials: AD
authors.lastname: Roberts
mesh_terms: D002560:Cerebrovascular Circulation; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D007553:Isotope Labeling / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods
chemical_list: D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated; C029999:fluoromethane