Production of [17F]CH3F (t1/2=65 s), an improved PET tracer for rCBF measurement.
Production of 17F (t1/2=65 s) in the form of [17F] F2 has been achieved using both the 20Ne(p,alpha)17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH3F (>60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi /microA for protons and 44 mCi/microA for deuterons have been measured for [17F]F2.
Barnhart
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Medical Physics, University of Wisconsin, 1500 N. Highland Ave. T-121 Waisman Center, Madison, WI 53705, USA. tebarnhart@wisc.edu
Converse
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Dabbs
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Schueller
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Stone
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Nickles
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Roberts
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D002560:Cerebrovascular Circulation; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D007553:Isotope Labeling / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods
D005462:Fluorine Radioisotopes; D006845:Hydrocarbons, Fluorinated; C029999:fluoromethane