title: Protection of oral or intestinal candidiasis in mice by oral or intragastric administration of herbal food, clove (Syzygium aromaticum).
abstract: We examined the effect of a clove (Syzygium aromaticum) administered by two different routes on Candida albicans growth, using a murine oral candidiasis model. When the clove preparation was administered into the oral cavity of Candida-infected mice, their oral symptoms were improved and the number of viable Candida cells in the cavity was reduced. In contrast, when the clove preparation was administered intragastrically, oral symptoms were not improved, but viable cell numbers of Candida in the stomach and feces were decreased. These findings demonstrate that oral intake of an herbal food, clove, may suppress the overgrowth of C. albicans in the alimentary tract including the oral cavity.
authors.affiliation: Research and Development Division, S & B Foods Inc., 38-8 Miyamoto-cho, Itabashiku, Tokyo 174-8651, Japan.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Taguchi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Toshio
authors.initials: T
authors.lastname: Takizawa
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Inoue
authors.forename: Hideyo
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Abe
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy*; D002180:Candidiasis, Oral / Q000188:drug therapy*; D007410:Intestinal Diseases / Q000188:drug therapy* / Q000382:microbiology*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D027842:Syzygium / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts