A dammarane glycoside derived from ginsenoside Rb3.
A dammarane glycoside, designated compound Mx (C-Mx), was isolated from the hydrolysate of 20(S)-protopanaxadiol type ginsenosides containing G-Rb(3) from Panax notoginseng leaves with crude snailase. Its chemical structure was elucidated to be 20-O-beta-D-xylopyranosyl(1-->6)-beta-D-glucopyranosyl-20(S)-protopanaxadiol on the basis of spectral analysis. Its cytotoxicity against breast cancer cell line MCF-7 and effects on the sensitivity to doxocubicin of doxocubicin-resistant MCF-7 cells were also investigated. The new compound showed moderate cytotoxicity and partial reversal of doxocubicin resistance.
He
Kejiang
K
Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences.
Liu
Yong
Y
Yang
Yi
Y
Li
Peng
P
Yang
Ling
L
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D005260:Female; D036145:Ginsenosides / Q000737:chemistry*; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D005894:Panax / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology; D000097669:Dammaranes
D000900:Anti-Bacterial Agents; D004317:Doxorubicin; D036145:Ginsenosides; D006026:Glycoside Hydrolases; D014315:Triterpenes; D000097669:Dammaranes; C044463:ginsenoside Rb3