title: In vitro antifungal activity of dragon's blood from Croton urucurana against dermatophytes.
abstract: Based on ethnobotanical approach, the dragon's blood collected from Croton urucurana Baill. bark (Euphorbiaceae) was tested for antifungal activity against five dermatophytes by paper disk diffusion method. The minimal inhibitory concentration (MIC) showing no visible fungal growth was also determined, using tube dilution technique. The test dermatophytes were Tricophyton tonsurans, Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis and Epidermophyton floccossum. The dragon's blood (0.175-3.0 mg/ml) exhibited an inhibition zone range of 7.6-26.9 mm against all the tested fungi with minimal inhibitory concentrations of 1.25-2.5 mg/ml.
authors.affiliation: Departamento de Fisiologia e Farmacologia, FM, Universidade Federal do Ceará, Rua Cel Nunes de Melo, 1127, Porangabussu, Caixa Postal-3157, 60430-270 Fortaleza, CE, Brazil.
authors.forename: Luilma A
authors.initials: LA
authors.lastname: Gurgel
authors.forename: J J C
authors.initials: JJ
authors.lastname: Sidrim
authors.forename: Domingos T
authors.initials: DT
authors.lastname: Martins
authors.forename: V
authors.initials: V
authors.lastname: Cechinel Filho
authors.forename: Vietla S
authors.initials: VS
authors.lastname: Rao
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D029802:Croton; D019448:Ethnobotany; D008826:Microbial Sensitivity Tests; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts