Effects of low and high intra-abdominal pressure on immune response in laparoscopic cholecystectomy.
OBJECTIVE
Immunosuppression is directly related to the degree of trauma. The aim of this study is to compare the effects of low and high intra-abdominal pressure on immune response in moderate surgical trauma.


METHODS
Twenty-two patients, scheduled for laparoscopic cholecystectomy, were randomly allocated to one of 2 groups according to intra-abdominal pressure: low and high intra-abdominal pressure. This study was conducted in the Hacettepe University Faculty of Medicine, Operation Room, Ankara, Turkey. Serum interleukin (IL)-2 and IL-6 levels were measured.


RESULTS
Serum IL-2 showed a significant decrease before the incision in high intra-abdominal pressure group. The increase in serum IL-6 at the end of surgery and postoperatively was lower in low intra-abdominal pressure group.


CONCLUSIONS
These results, can be interpreted as the immune system, are less depressed when there is lower intra-abdominal pressure. This may have clinical implications in immunocompromised patients.
Basgul
Elif
E
Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Bahadir
Betul
B
Celiker
Varol
V
Karagoz
Ayse H
AH
Hamaloglu
Erhan
E
Aypar
Ulku
U
D000328:Adult; D000768:Anesthesia, General; D017081:Cholecystectomy, Laparoscopic / Q000379:methods*; D005260:Female; D006801:Humans; D006874:Hydrostatic Pressure; D007108:Immune Tolerance / Q000276:immunology; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011028:Pneumoperitoneum, Artificial / Q000379:methods*; D011183:Postoperative Complications / Q000276:immunology*
D007376:Interleukin-2; D015850:Interleukin-6