title: Prevalence of diabetes-associated autoantibodies in schoolchildren: the Karlsburg Type 1 Diabetes Risk Study.
abstract: This study attempts to assess the prevalence of diabetes-associated autoantibodies in a general population in the northeastern part of Germany, with emphasis on autoantibodies against glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA-2A), and insulin (IAA) by radioassays >/= 98th percentile, and AAbs binding on pancreatic sections (ICA) by immunofluorescence >/= 10 Juvenile Diabetes Foundation units. From a total of 11,840 schoolchildren tested for all four AAbs, 821 (6.9%) children were positive for single AAbs, whereas 83 (0.7%) had multiple AAbs. If the primary screening were performed by testing GADA/IA-2A/IAA, 94% of probands with single AAbs and all with multiple AAbs would be identified. The combinations of GADA/IA-2A, GADA/IAA, and IA-2A/IAA would identify 97.6, 98.8, and 85.5% of probands with multiple AAbs, respectively. Thus, combined AAb screening in the general population identifies those probands at risk for diabetes.
authors.affiliation: Institute of Pathophysiology, Ernst Moritz Arndt University of Greifswald, Greifswalder Str. 11b, D-17495 Karlsburg, Germany. schlosse@uni-greifswald.de
authors.forename: Michael
authors.initials: M
authors.lastname: Schlosser
authors.forename: Martina
authors.initials: M
authors.lastname: Strebelow
authors.forename: Ilona
authors.initials: I
authors.lastname: Rjasanowski
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kerner
authors.forename: Ralf
authors.initials: R
authors.lastname: Wassmuth
authors.forename: Manfred
authors.initials: M
authors.lastname: Ziegler
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005858:Germany / Q000453:epidemiology; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D015995:Prevalence; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000276:immunology; D011863:Radioimmunoassay; D012307:Risk Factors
chemical_list: D001323:Autoantibodies; C024211:islet cell antibody; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases; D005968:Glutamate Decarboxylase