title: Are there subgroups of bulimia nervosa based on comorbid psychiatric disorders?
abstract: OBJECTIVE
  The current study sought to determine whether there are subtypes of bulimia nervosa (BN) differentiated by comorbid psychiatric disorders.
  
  
  METHODS
  Data on comorbid psychiatric diagnoses in female relatives of probands and controls in the Collaborative Study of the Genetics of Alcoholism (COGA) who met criteria for BN (as outlined in the 3rd Rev. ed. of the Diagnostic and Statistical Manual of Mental Disorders) were analyzed using latent class analysis. Resulting latent classes were compared on a variety of variables related to impulsive behaviors and psychological functioning.
  
  
  RESULTS
  The best-fitting solution, a two-class model, yielded one class (72%) characterized by substance dependence, depression, antisocial personality disorder (ASPD), and anxiety disorders, and another characterized by depression. The highly comorbid class had more suicidality, more daily smokers, sought help for emotional problems, and had lower Global Assessment of Functioning (GAF) scores compared with those in the comorbid depression only class.
  
  
  CONCLUSIONS
  Latent class findings suggest the existence of two classes of BN differentiated by substance dependence, impulsive behaviors, and poorer psychological functioning.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
authors.forename: Alexis E
authors.initials: AE
authors.lastname: Duncan
authors.forename: Rosalind J
authors.initials: RJ
authors.lastname: Neuman
authors.forename: John
authors.initials: J
authors.lastname: Kramer
authors.forename: Samuel
authors.initials: S
authors.lastname: Kuperman
authors.forename: Victor
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: Theodore
authors.initials: T
authors.lastname: Reich
authors.forename: Kathleen K
authors.initials: KK
authors.lastname: Bucholz
mesh_terms: D000328:Adult; D002032:Bulimia / Q000145:classification* / Q000235:genetics / Q000523:psychology*; D016022:Case-Control Studies; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D007174:Disruptive, Impulse Control, and Conduct Disorders; D005260:Female; D006801:Humans; D001523:Mental Disorders / Q000523:psychology*; D008875:Middle Aged; D010375:Pedigree; D011594:Psychometrics; D019966:Substance-Related Disorders