A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury.
Experimental research during the past decade has greatly increased our understanding of the pathophysiology of traumatic brain injury (TBI) and allowed us to develop neuroprotective pharmacological therapies. Encouraging results of experimental pharmacological interventions, however, have not been translated into successful clinical trials, to date. Traumatic brain injury is now believed to be a progressive degenerative disease characterized by cell loss. The limited capacity for self-repair of the brain suggests that functional recovery following TBI is likely to require cellular transplantation of exogenous cells to replace those lost to trauma. Recent advances in central nervous system transplantation techniques involve technical and experimental refinements and the analysis of the feasibility and efficacy of transplantation of a range of stem cells, progenitor cells and postmitotic cells. Cellular transplantation has begun to be evaluated in several models of experimental TBI, with promising results. The following is a compendium of these new and exciting studies, including a critical discussion of the rationale and caveats associated with cellular transplantation techniques in experimental TBI research. Further refinements in future research are likely to improve results from transplantation-based treatments for TBI.
Schouten
Joost W
JW
Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Fulp
Carl T
CT
Royo
Nicolas C
NC
Saatman
Kathryn E
KE
Watson
Deborah J
DJ
Snyder
Evan Y
EY
Trojanowski
John Q
JQ
Prockop
Darwin J
DJ
Maas
Andrew I R
AI
McIntosh
Tracy K
TK
D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology / Q000628:therapy*; D002460:Cell Line / Q000502:physiology; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D009410:Nerve Degeneration / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D009416:Nerve Regeneration / Q000502:physiology; D033581:Stem Cell Transplantation / Q000379:methods / Q000639:trends*; D013234:Stem Cells / Q000502:physiology*