title: Reducing the cost of post-exposure rabies prophylaxis: efficacy of 0.1 ml PCEC rabies vaccine administered intradermally using the Thai Red Cross post-exposure regimen in patients severely exposed to laboratory-confirmed rabid animals.
abstract: Purified chick embryo cell rabies vaccine (PCECV) administered as 0.1 ml intradermally according to the Thai Red Cross (TRC) regimen could reduce the cost of PEP by up to 84% when compared to the traditional five-dose Essen regimen. To confirm the efficacy of 0.1 ml of PCECV using the TRC regimen, a clinical trial was conducted in 113 patients presenting with category III exposures from confirmed rabid animals at two bite referral centres in the Philippines. Patients were monitored monthly for 1 year after exposure. PCECV was well tolerated, no vaccine-related serious adverse events occurred and all patients were alive 1 year after their initial exposure.
authors.affiliation: Research Institute for Tropical Medicine, Alabang, Muntinlupa, Philippines.
authors.forename: Beatriz P
authors.initials: BP
authors.lastname: Quiambao
authors.forename: Efren M
authors.initials: EM
authors.lastname: Dimaano
authors.forename: Cristina
authors.initials: C
authors.lastname: Ambas
authors.forename: Rolan
authors.initials: R
authors.lastname: Davis
authors.forename: Angelika
authors.initials: A
authors.lastname: Banzhoff
authors.forename: Claudius
authors.initials: C
authors.lastname: Malerczyk
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002642:Chick Embryo; D002648:Child; D002675:Child, Preschool; D017046:Cost Savings / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D007115:Immunization Schedule; D008875:Middle Aged; D011818:Rabies / Q000191:economics* / Q000453:epidemiology / Q000517:prevention & control; D011819:Rabies Vaccines / Q000191:economics* / Q000627:therapeutic use; D012011:Red Cross / Q000191:economics*; D013785:Thailand / Q000453:epidemiology
chemical_list: D011819:Rabies Vaccines