Missing the target: ubiquitin ligase drugs stall.
Garber
Ken
K
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001897:Boronic Acids / Q000009:adverse effects / Q000627:therapeutic use*; D000069286:Bortezomib; D006801:Humans; D000075687:NEDD8 Protein; D009687:Nuclear Proteins / Q000187:drug effects; D011480:Protease Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D011518:Proto-Oncogene Proteins / Q000187:drug effects; D051736:Proto-Oncogene Proteins c-mdm2; D011719:Pyrazines / Q000009:adverse effects / Q000627:therapeutic use*; D044767:Ubiquitin-Protein Ligases / Q000037:antagonists & inhibitors*; D014452:Ubiquitins / Q000187:drug effects
D000970:Antineoplastic Agents; D001897:Boronic Acids; D000075687:NEDD8 Protein; C082860:NEDD8 protein, human; D009687:Nuclear Proteins; D011480:Protease Inhibitors; D011518:Proto-Oncogene Proteins; D011719:Pyrazines; D014452:Ubiquitins; D000069286:Bortezomib; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; D044767:Ubiquitin-Protein Ligases