Solitary bony metastasis from renal cell carcinoma: significance of surgical treatment.
To define the importance of the type of surgical treatment, we retrospectively analyzed the survival rate of 60 patients with solitary bony metastasis from renal cell carcinoma. Thirteen patients had wide resection, 20 had local stabilization, and 27 patients had no surgical treatment, but had adjuvant treatment alone. The 1-, 3-, and 5-year survival rates were 83%, 45%, and 23%, respectively. Patients with surgical treatment (wide or intralesional resection) survived longer compared with patients who had no surgical treatment but had adjuvant treatment modalities. However, there was no survival advantage for patients who had a wide resection of the lesion compared with patients who had intralesional resection or intramedullary stabilization alone. Our results indicate that wide surgical excision of a solitary bony metastasis from renal cell carcinoma is not mandatory to improve survival. However, because three of 20 patients (15%) treated with stabilization alone had local disease progression, wide resection of metastatic lesions and stabilization may be necessary to prevent local disease progression and complications.
Fuchs
Bruno
B
Department of Orthopedics, Mayo Clinic, 200 SW First Street, Rochester, MN 55905, USA. bruno.fuchs@balgrist.ch
Trousdale
Robert T
RT
Rock
Michael G
MG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D012189:Retrospective Studies; D012737:Sex Factors; D016019:Survival Analysis