[Sudden death in organophosphoric poisoning--an unaccountable pathophysiologic mechanism?].
Sudden death related in literature to appear in IV-th - VIII-th day from organophosphoric intoxication does not have an unanimous accepted physiopathologic explanation.


OBJECTIVE
Pharmacodynamic study of myocardial trichlorfon level in acute experiment.


METHODS
Gas chromatographic determination of myocardial trichlorfon quantity in an experiment on white, male Wistar rats, daily sacrificed for the heart, until the tenth day from an digestive administration of a dose of 200mg/kg trichlorfon. RESULTS (mcg/g myocardial tissue): I day = 8, II day = 13.63, III day = 15, IV day = 18.96, V day = 19.6, VI day = 20.83, VII day = 21.21, VIII day = 21.33, IX day = 19.69, X day = 19.41.


CONCLUSIONS
An organophosphoric direct toxic mechanism is suggested, through accumulation over time of a certain level of myocardial concentration.
Petriş
O
O
Universitatea de Medicină şi Farmacie Gr.T. Popa, Facultatea de Medicină, Clinica Medicală a Spitalului de Urgente.
Gradinariu
Felicia
F
Totolin
M
M
Hurjui
J
J
Frasin
M
M
Lionte
Cătălina
C
Bologa
Cristina
C
D000818:Animals; D002849:Chromatography, Gas; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D006331:Heart Diseases / Q000139:chemically induced* / Q000378:metabolism*; D007306:Insecticides / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D023421:Models, Animal; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014236:Trichlorfon / Q000493:pharmacokinetics* / Q000633:toxicity
D007306:Insecticides; D014236:Trichlorfon