title: Clonality analysis by HUMARA assay in Spanish females with essential thrombocythemia and polycythemia vera.
abstract: Analysis of the human androgen receptor gene (HUMARA) allows clonality to be assessed in essential thrombocythemia (ET) and polycythemia vera (PV). We studied clonality in 44 patients with ET, 18 with PV and in 64 healthy controls. The X-chromosome inactivation pattern was analyzed by HUMARA-polymerase chain reaction on DNA from purified granulocytes, T lymphocytes and the CD3- fraction of mononuclear cells.
authors.forename: Lurdes
authors.initials: L
authors.lastname: Zamora
authors.forename: Blanca
authors.initials: B
authors.lastname: Espinet
authors.forename: Lourdes
authors.initials: L
authors.lastname: Florensa
authors.forename: Carles
authors.initials: C
authors.lastname: Besses
authors.forename: Beatriz
authors.initials: B
authors.lastname: Bellosillo
authors.forename: Francesc
authors.initials: F
authors.lastname: Solé
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017252:CD3 Complex / Q000096:biosynthesis; D016022:Case-Control Studies; D041321:Chromosomes, Human, X; D005260:Female; D006098:Granulocytes / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D011087:Polycythemia Vera / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics*; D013030:Spain; D013601:T-Lymphocytes / Q000378:metabolism; D013921:Thrombocytopenia / Q000235:genetics*
chemical_list: D017252:CD3 Complex; D011944:Receptors, Androgen