A case of pseudomembranous colitis associated with rifampin.
Pseudomembranous colitis is known to develop with long-term antibiotic administration, but antitubercular agents are rarely reported as a cause of this disease. We experienced a case of pseudomembranous colitis associated with rifampin. The patient was twice admitted to our hospital for the management of frequent bloody, mucoid, jelly-like diarrhea and lower abdominal pain that developed after antituberculosis therapy that included rifampin. Sigmoidoscopic appearance of the rectum and sigmoid colon and mucosal biopsy were compatible with pseudomembranous colitis. The antitubercular agents were discontinued and metronidazole was administered orally. The patient's symptoms were resolved within several days. The antituberculosis therapy was changed to isoniazid, ethambutol and pyrazinamide after a second bout of colitis. The patient had no further recurrence of diarrhea and abdominal pain. We report here on a case of pseudomembranous colitis associated with rifampin.
Park
Ji Young
JY
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Kim
Joon Seok
JS
Jeung
Sun Jong
SJ
Kim
Myung Sook
MS
Kim
Seok Chan
SC
D000368:Aged; D000369:Aged, 80 and over; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D003967:Diarrhea / Q000209:etiology; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced*; D006801:Humans; D008297:Male; D012293:Rifampin / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D000904:Antibiotics, Antitubercular; D012293:Rifampin