Small molecule microarrays: recent advances and applications.
Directed or exploratory drug development programs constantly seek robust screening platforms for the high fidelity identification and validation of potential targets. Small-molecule microarrays (SMMs) have risen to this call by elegantly forging the capability of combinatorial chemistry in producing myriad compounds with the powerful throughput afforded by microarrays. This synergism offers scientists a versatile tool for rapid compound analysis and discovery. Microarrays of small molecules have already been successfully applied in important areas ranging from protein profiling to the discovery of therapeutic leads. Recent interesting developments towards improved immobilization strategies and library creation methods, together with novel advances herein described, have set the stage for SMMs to take on wider and more routine applications in academia and industry. As a rapidly maturing technology, SMMs pave the way forward in high-throughput exploration, both in the identification of biologically significant natural and synthetic small molecules and in harnessing their vast potential towards medicinal and diagnostic applications.
Uttamchandani
Mahesh
M
Department of Biological Sciences, National University of Singapore, 3 Science Drive 3, 117543, Singapore.
Walsh
Daniel P
DP
Yao
Shao Q
SQ
Chang
Young-Tae
YT
D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D007103:Immobilization; D046228:Microarray Analysis / Q000379:methods* / Q000639:trends; D008968:Molecular Conformation; D015335:Molecular Probes; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods / Q000639:trends; D040081:Protein Array Analysis / Q000379:methods / Q000639:trends; D012680:Sensitivity and Specificity; D013499:Surface Properties
D015335:Molecular Probes