title: Value of SPET/CT image fusion in the assessment of neuroendocrine tumours with 111In-pentetreotide scintigraphy.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the impact and clinical value of anatomical-functional image fusion in the study interpretation and clinical management of patients with neuroendocrine tumours (NET) using somatostatin receptor scintigraphy (SRS) and combined transmission and emission tomography -- single-photon emission tomography/CT (SPET/CT).
  
  
  METHODS
  Twelve patients (8 female and 4 male; age range 32-74 y, mean 56 y) with proven or clinically suspected NET were studied with routine planar SRS and SPET/CT at 2 and 24 hours after injection of 111-222 MBq 111In-Pentetreotide. Seven patients came for staging/follow-up and 5 patients for primary tumour localization with staging. Analysis of fused images (SPET/CT) was done on a patient basis, with separated evaluation of SPET, low-dose CT images and fusion images. The gold standard for presence or absence of malignancy was pathology or clinical and imaging follow-up data.
  
  
  RESULTS
  SRS was negative in 6 patients and positive in 6. SPET/CT provided no additional information in 6 patients, including all 6 negative studies. SPET/CT improved localization of SPET detected lesions in 6 positive studies. It defined the extent of the disease and showed bone involvement in 3 of the 6 positive studies. SPET/CT affected the diagnostic interpretation in 6 patients (50 %) and induced changes of management in 3 (25 %).
  
  
  CONCLUSIONS
  The results of this study indicate that combined anatomical-functional imaging with SPET/CT significantly improves tumour localization and characterization, contributing to a better therapeutic management of patients with NET.
authors.affiliation: Serviço de Medicina Nuclear, Hospitais da Universidade de Coimbra, Portugal. smnhuc@mail.telepac.pt
authors.forename: A Paula
authors.initials: AP
authors.lastname: Moreira
authors.forename: L Hugo
authors.initials: LH
authors.lastname: Duarte
authors.forename: F
authors.initials: F
authors.lastname: Vieira
authors.forename: F
authors.initials: F
authors.lastname: João
authors.forename: J Pedroso de
authors.initials: JP
authors.lastname: Lima
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D013004:Somatostatin / Q000031:analogs & derivatives*; D014057:Tomography, X-Ray Computed
chemical_list: D007205:Indium Radioisotopes; D013004:Somatostatin; C081788:pentetreotide