Crystalloid deposits in the kidney.
Light chain-producing lymphoproliferative disorders such as multiple myeloma are frequently complicated by renal impairment. Typically, the renal biopsy of a patient with renal failure caused by multiple myeloma shows cast nephropathy, but occasionally crystals may be seen. We describe the case of a patient with acute renal failure caused by multiple myeloma in which, on renal and bone marrow biopsy, there were widespread crystalloid deposits. Crystalloid nephropathy is a very rare condition associated with multiple myeloma and other light chain-secreting disorders. An underlying lymphoproliferative disorder should be considered in the differential diagnosis if crystalloid deposits are seen on a renal or other tissue biopsy.
Keller
Lisa Suzanne
LS
Renal Unit, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia.
Faull
Randall James
RJ
Smith
Peter
P
Swift
Jeffrey
J
Bannister
Kym Malcolm
KM
Otto
Sophie
S
Peh
Chen Au
CA
D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology*; D003460:Crystallization; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000737:chemistry*; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology*
D007147:Immunoglobulin Light Chains