Interaction of dopamine and acetylcholine with an amphiphilic resorcinarene receptor in aqueous micelle system.
The molecular recognition of neurotransmitters, dopamine and acetylcholine with an amphiphilic resorcinarene receptor was investigated in an aqueous sodium dodecylsulfate (SDS) micelle system by 1H NMR measurements. The interaction distances of these neurotransmitters from the hydrophilic cavity of the amphiphilic receptor were estimated based on the calculation of the ring current shift using the atomic coordinates obtained from molecular dynamics calculation.
Demura
Makoto
M
Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan. demura@sci.hokudaia.ac.jp
Yoshida
Tsutomu
T
Hirokawa
Takatsugu
T
Kumaki
Yasuhiro
Y
Aizawa
Tomoyasu
T
Nitta
Katsutoshi
K
Bitter
Isván
I
Tóth
Klára
K
D000109:Acetylcholine / Q000737:chemistry*; D047250:Calixarenes; D004298:Dopamine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D008823:Micelles; D008958:Models, Molecular; D015394:Molecular Structure; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D012015:Reference Standards; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
D008823:Micelles; C466160:resorcinarene; D014867:Water; D047250:Calixarenes; D012967:Sodium Dodecyl Sulfate; D010649:Phenylalanine; D000109:Acetylcholine; D004298:Dopamine