title: Comparison of the strain Doppler echocardiographic features of familial amyloid polyneuropathy (FAP) and light-chain amyloidosis.
abstract: Previous work has demonstrated that familial amyloid polyneuropathy (FAP) and light-chain amyloidosis with similar degrees of cardiac involvement cannot be distinguished by standard echocardiographic parameters, yet the severity of congestive heart failure and cardiac mortality is much less in FAP. It was therefore hypothesized that strain and strain-rate imaging, sensitive markers of longitudinal systolic dysfunction, might detect a difference in left ventricular function between FAP and light-chain amyloidosis that could account for the clinical differences.
authors.affiliation: Division of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Ogiwara
authors.forename: Jun
authors.initials: J
authors.lastname: Koyama
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Osamu
authors.initials: O
authors.lastname: Kinoshita
authors.forename: Rodney H
authors.initials: RH
authors.lastname: Falk
mesh_terms: D028227:Amyloid Neuropathies, Familial / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D007147:Immunoglobulin Light Chains