Costal-2: a scaffold for kinases mediates Hedgehog signaling.
Drosophila genetics has identified several components of the Hedgehog signaling pathway, but the mechanism by which they act remains elusive. In this issue of Developmental Cell, a report by Zhang et al. provides evidence that the kinesin-related protein Costal-2 forms a multi-component scaffold that mediates Hedgehog signaling.
Ishii
Shunsuke
S
Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.
D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology*; D053823:Hedgehog Proteins; D016547:Kinesins / Q000502:physiology*; D011494:Protein Kinases / Q000502:physiology; D015398:Signal Transduction
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; C107452:cos protein, Drosophila; C077245:hh protein, Drosophila; D011494:Protein Kinases; D016547:Kinesins