Psychological stress impairs hepatic blood flow via central CRF receptors in mice.
Some previous works have further expanded the 'Brain-Gut axis', that is a bi-directional interaction between the gut and brain function, into a relationship of the brain with the liver. However, all the details of such brain-liver relationship were not fully understood because appropriate animal models had not been established yet. Here we developed a novel animal model, in which hepatic blood flow of conscious mice could be measured in real-time. In addition, using this model, we also demonstrated that exposure to psychological stress considerably reduced hepatic blood flow via central CRF receptors. Thus, this new model is considered to be a useful and promising tool for elucidating the precise effects of emotional factors on liver function.
Chida
Yoichi
Y
Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Sudo
Nobuyuki
N
Kubo
Chiharu
C
D000818:Animals; D001921:Brain / Q000502:physiology*; D008102:Liver Circulation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018019:Receptors, Corticotropin-Releasing Hormone / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*
D018019:Receptors, Corticotropin-Releasing Hormone