title: [Generalized granuloma annulare and drug-induced immunodeficiency].
abstract: BACKGROUND
  Granuloma have already been described in the context of immunosuppression. We report six cases of widespread granuloma annulare occurring in patients with drug-induced immunosuppression.
  
  
  METHODS
  There were four women and two men, with mean age of 61 years (35-76). Three patients were treated with chemotherapy for breast (2 cases) and liver cancer. One woman was given chemotherapy for Hodgkin's disease. One had undergone liver transplantation and was given cyclosporine, another was treated with systemic steroids for polyarthritis. All had generalized non-photoexposed granuloma annulare, composed of multiple erythematous papules, sometimes with annular pattern. The lesions were localized on the trunk, legs and arms. Histopathology revealed granuloma annulare in each patient.
  
  
  CONCLUSIONS
  These six cases suggest a relationship between drug-induced immunodeficiency and generalized granuloma annulare. The immune dysregulation induced by the drugs may have been responsible for the formation of granuloma annulare.
authors.affiliation: Clinique Dermatologique des Hôpitaux Universitaires de Strasbourg.
authors.forename: M
authors.initials: M
authors.lastname: Paul
authors.forename: B
authors.initials: B
authors.lastname: Cribier
authors.forename: E
authors.initials: E
authors.lastname: Heid
authors.forename: E
authors.initials: E
authors.lastname: Grosshans
authors.forename: D
authors.initials: D
authors.lastname: Lipsker
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016460:Granuloma Annulare / Q000139:chemically induced*; D006801:Humans; D007049:Iatrogenic Disease; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged