Monocyte chemoattractant protein-1 and recurrent cardiovascular events in patients with stable coronary heart disease.
BACKGROUND
Monocyte chemoattractant protein-1 (MCP-1) participates in the recruitment of mononuclear cells to the vessel wall.


OBJECTIVE
The aim of the study was to evaluate the potential association between serum concentration of MCP-1 and risk of future cardiovascular events in patients with chronic coronary heart disease.


METHODS
A nested case control design was used. Baseline serum samples were taken from patients with coronary heart disease who were enrolled in a secondary prevention study. The MCP-1 levels were measured in those patients who had recurrent cardiovascular events during follow-up (n = 233) and compared with levels in age- and gender-matched controls.


RESULTS
There were no differences in serum MCP-1 levels between cases and controls. The relative odds of a recurrent cardiovascular event for each 1 standard deviation difference in MCP-1 serum concentration (160 pg/ml) was 1.19 (95% confidence interval, 0.95-1.45). No increase in the relative odds for recurrent cardiovascular events was observed per increasing tertiles of MCP-1 concentrations.


CONCLUSIONS
Elevated MCP-1 levels are not associated with long-term risk of cardiovascular events in patients with stable coronary disease.
Haim
Moti
M
Department of Cardiology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel. motih@netvision.net.il
Tanne
David
D
Boyko
Valentina
V
Reshef
Tamar
T
Goldbourt
Uri
U
Battler
Alexander
A
Mekori
Yoseph A
YA
Behar
Solomon
S
D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood*; D002908:Chronic Disease; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D016757:Death, Sudden, Cardiac / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000209:etiology; D016017:Odds Ratio; D011446:Prospective Studies; D012008:Recurrence; D018570:Risk Assessment; D020521:Stroke / Q000097:blood* / Q000209:etiology; D013997:Time Factors
D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2