title: Three new diterpenes and the biological activity of different extracts of Jasonia montana.
abstract: Three new diterpenes, namely jasonin-a (1), jasonin-b (2), and jasonin-c (3) were isolated from the aerial parts of Jasonia montana (Asteraceae). Their structures were elucidated on the basis of spectral data as [(1E)-2-((2S)-1,2,5-trimethylbicyclo[3.2.l]octan-8-yl)vinyl] benzene-3-carboxylic acid (1), [3-((2S, 5S)-1,2, 5-trimethylcycloheptanyl)propyl]benzene-3-carboxylic acid (2), and [(1E)-3-((7R)-1,7-dimethy-4-methylenecycloheptanyl)prop-1-enyl] benzene-3-carboxylic acid (3). In addition, the previously reported 5,7,3'-trihydroxy-3,6,4'-trimethoxy flavone designated as centaureidin (4), was also isolated and characterized from this source. The different extracts of the plant were also screened for hypoglycemic, antidiabetic, and antimicrobial activities, wherein the petroleum ether and ethanolic extracts exhibited hypoglycemic and antidiabetic activity, and the petroleum ether and chloroform extracts showed antimicrobial activity.
authors.affiliation: Medicinal, Aromatic and Poisonous Plants Research Center, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
authors.forename: Tawfeq A
authors.initials: TA
authors.lastname: Al-Howiriny
authors.forename: Adnan J
authors.initials: AJ
authors.lastname: Al-Rehaily
authors.forename: Joanna R
authors.initials: JR
authors.lastname: Polsc
authors.forename: John R
authors.initials: JR
authors.lastname: Porter
authors.forename: Jaber S
authors.initials: JS
authors.lastname: Mossa
authors.forename: Bahar
authors.initials: B
authors.lastname: Ahmed
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology
chemical_list: C499958:((1E)-2-((2S)-1,2,5-trimethylbicyclo(3.2.l)octan-8-yl)vinyl) benzene-3-carboxylic acid; C499956:((1E)-3-((7R)-1,7-dimethy-4-methylenecycloheptanyl)prop-1-enyl) benzene-3-carboxylic acid; C499957:(3-((2S, 5S)-1,2, 5-trimethylcycloheptanyl)propyl)benzene-3-carboxylic acid; D004224:Diterpenes; D005419:Flavonoids; D007004:Hypoglycemic Agents; D010936:Plant Extracts; C083161:centaureidin