Two new triterpenes from the seeds of Trichosanthes cucumeroides.
Two new triterpenes named 7-oxodihydrokarounitriol (1) and 7,11-dioxodihydrokarounidiol (2), and one known triterpene, 7-oxodihydrokarounidiol (3), were isolated from the unsaponifiable matter of the seeds of Trichosanthes cucumeroides. The structures of 1 and 2 were elucidated as (3alpha, 11beta, 13alpha, 14beta, 20alpha)-3,11,29-trihydroxy-13-methyl-26-norolean-8-ene-7-one, and (3alpha,13alpha,14beta,20alpha)-3,29-dihydroxy-13-methyl-26-norolean-8-ene-7,11-dione on the basis of extensive NMR (1H, 13C, 1H-1H COSY, DEPT, HMQC, HMBC and NOESY) and MS studies.
Chao
Zhimao
Z
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, 16 Dongzhimennei Nanxiaojie, Dongcheng, Beijing 100700, China. chaozhimao@sina.com
Shibusawa
Yoichi
Y
Yanagida
Akio
A
Shimotakahara
Sakurako
S
Shindo
Heisaburo
H
D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis; D012639:Seeds / Q000737:chemistry; D029778:Trichosanthes / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification
C499948:7,11-dioxodihydrokarounidiol; D010936:Plant Extracts; D014315:Triterpenes; C076913:7-oxodihydrokarounidiol; D009828:Oleanolic Acid