Management of malignant pericardial effusion with instillation of mitomycin C in non-small cell lung cancer.
BACKGROUND
To evaluate the clinical efficacy and safety of mitomycin C in the local control of malignant pericardial effusion, we carried out a trial of pericardial drainage with local instillation of mitomycin C in eight patients who suffered from cardiac tamponade or symptomatic large pericardial effusion caused by advanced non-small cell lung cancer.


METHODS
After complete removal of the pericardial effusion by an ultrasound-guided inserted catheter, 2 mg of mitomycin C was instilled into the pericardial space via the catheter.


RESULTS
The drainage catheter was successfully removed in all patients. The duration of pericardial drainage ranged from 7 to 14 days (median 10.5 days). Six of the eight patients achieved a complete remission of pericardial effusions without any adverse effects.


CONCLUSIONS
Intrapericardial instillation of 2 mg of mitomycin C was feasible and demonstrated a promising response against malignant pericardial effusion resulting from non-small cell lung cancer.
Kaira
Kyoichi
K
Maebashi Red Cross Hospital, Department of Respiratory Medicine, 3-21-36, Asahi-cho, Maebashi, Gunma 377-0014, Japan. k-kaira@maebashi.jrc.or.jp
Takise
Atsushi
A
Kobayashi
Go
G
Utsugi
Mitsuyoshi
M
Horie
Takeo
T
Mori
Takanori
T
Imai
Hisao
H
Inazawa
Masahito
M
Mori
Masatomo
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications*; D002305:Cardiac Tamponade / Q000209:etiology; D004322:Drainage; D005260:Female; D006801:Humans; D007322:Instillation, Drug; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D010490:Pericardial Effusion / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin