Shifted from Wnt to Hedgehog signaling pathways.
Two papers in recent issue of Developmental Cell (Glise et al. 2005; Gorfinkiel et al. 2005) have shown that Shifted, a Drosophila ortholog of Wnt Inhibitory Factor (WIF), modulates the distribution of Hedgehog protein in the wing imaginal disc through a Wnt-independent mechanism.
Han
Chun
C
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Lin
Xinhua
X
D000818:Animals; D006801:Humans; D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D004330:Drosophila / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D029721:Drosophila Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D017344:Genes, Insect; D053823:Hedgehog Proteins; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology; D009154:Mutation; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D014921:Wings, Animal / Q000254:growth & development; D051153:Wnt Proteins
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; C077245:hh protein, Drosophila; D036341:Intercellular Signaling Peptides and Proteins; D012097:Repressor Proteins; C485569:WIF1 protein, human; D051153:Wnt Proteins