title: Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma.
abstract: Six furanogermacrane sesquiterpenes, pseudoneolinderane (1), linderalactone (2), zeylanidine (3), zeylanicine (4), deacetylzeylanidine (5), and neolitrane (6), isolated from the stems of Neolitsea parvigemma, were tested for anti-inflammatory activities. Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB. The IC50 of 1 and 2 were found to be 3.21 and 8.48 microg/mL, respectively.
authors.affiliation: Tajen Institute of Technology, Ping Tung Hsien 907, Taiwan.
authors.forename: Keh-Shaw
authors.initials: KS
authors.lastname: Chen
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Hsieh
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D019770:Lauraceae / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D013481:Superoxides / Q000032:analysis
chemical_list: D000893:Anti-Inflammatory Agents; D012717:Sesquiterpenes; D013481:Superoxides