[Molecular-genetic status of the adolescents living in the condition of the constant influense of low dose radiation].
In the present investigation the analysis of the cytogenetic status and some blood characteristics of the adolescents from the contaminated area of Vulka-2 in Belarus has been done. The obtained data testifed that patients living in the condition of chronic radiation influence had essentially increased general frequency of all types of chromosome aberrations. First of all the elevated level of radiation markers is marked (0.54 +/- 0.11 and 0.11 +/- 0.05% in control. group, p < 0.05), the growth of double fragments (1.27 +/- 0.17 and 0.40 +/- 0.09% in control group, p < 0.05). The Spearmen correlation alalysis has revealed statistically significant increase of apoptosis level on the background of increased level of micronuclei (R = 0.832, p < 0.01). Thus our data testify that the degree of the biological homeostasis violation is intimately connected with the level of genome destabilization.
Mel'nov
S B
SB
Lebedeva
T B
TB
D000293:Adolescent; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D001773:Blood Cells / Q000166:cytology / Q000528:radiation effects; D001774:Blood Chemical Analysis; D016022:Case-Control Studies; D002648:Child; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D008297:Male; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D002094:Republic of Belarus
D015415:Biomarkers