Agents protecting against sepsis from the roots of Angelica dahurica.
In the course of isolating agents preventing sepsis from the EtOAc extract of the roots of Angelica dahurica, four known furanocoumarins, isoimperatorin (1), oxypeucedanin (2), (+/-)-byakangelicin (3), and (+)-oxypeucedanin hydrate (4), were isolated as active compounds based on the in vivo assay model of sepsis induced by lipopolysaccharide (LPS) and D-galactosamine (D-GalN). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 20% for the control experiment) and decreased the plasma levels of tumor necrosis factor-alpha and alanine aminotransferase in mice adminstered LPS/D-GalN.
Song
Dong-Keun
DK
Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine, Chunchon 200-702, Republic of Korea.
Kim
Ji-Yeon
JY
Li
Gao
G
Lee
Kyeung-Seon
KS
Seo
Chang-Seob
CS
Yan
Ji-Jing
JJ
Jung
Jun-Sub
JS
Kim
Hyo-Jin
HJ
Chang
Hyun-Wook
HW
Son
Jong-Keun
JK
D029969:Angelica; D000818:Animals; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D018517:Plant Roots; D018805:Sepsis / Q000097:blood / Q000517:prevention & control*
D010936:Plant Extracts