[Effects of YM injection on oxidative stress injury in renal warm ischemia/reperfusion].
OBJECTIVE
This study was undertaken to determine whether YM injection would attenuate warm I/R injury in mice.


METHODS
Renal warm I/R was induced in C57BL/6 males, and the mice were sacrificed 24 hours post-reperfusion. YM was given intraperitoneally 12 hours and 30 min before I/R. The effects of YM on oxidative stress and proinflammatory mediators caused by renal I/R injury were assayed.


RESULTS
Renal I/R caused severe injuries in the kidneys of mice. In the presence of YM at doses of 5, 15 and 25 mg/kg, the kidney malondialdehyde (MDA) content reduced by 16.6%, 25.0% and 35.5% respectively, and the kidney superoxide dismutase (SOD) activities were elevated by about 38.7%, 48.3% and 76.1% respectively. ICAM-1 expression was dramatically suppressed in the presence of YM (25 mg/kg).


CONCLUSIONS
YM attenuates the renal warm I/R injury at least partially via decreasing the neutrophils infiltration and suppressing the over-expression of adhesion molecules.
Feng
Li
L
Key Laboratory of Transplant Engineering and Immunology of Health Ministry of China, West China Hospital, Sichuan University, Chengdu 610041, China.
Cheng
Feng
F
Li
Sheng-fu
SF
Xiong
Ying
Y
Cheng
Jing-qiu
JQ
Lu
Yan-rong
YR
Li
You-ping
YP
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006358:Hot Temperature; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007668:Kidney / Q000098:blood supply* / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013312:Stress, Physiological; D013482:Superoxide Dismutase / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D018799:Intercellular Adhesion Molecule-1; D013482:Superoxide Dismutase