title: [Effects of MSF on melanocyte adhesion and migration in vitro].
abstract: OBJECTIVE
  To investigate the Malytea Scurfpea fruit (MSF) on melanocyte adhesion and migration.
  
  
  METHODS
  Human epidermal melanocytes were treated with MSF and Ginger respectively, then adhesion to bovine serum fibronectin-coated culture dishes was checked. Control and treated cells were also examined for migration into micropore filters coated with the same protein.
  
  
  RESULTS
  Compared with control, MSF treated melanocytes were obviously easier to adhere to the dishes and move into the filters in a dose-dependent manner. When the dose of MSF was 200 mg x L(-1), it could not reincrease melanocyte adhesion and migration. At 10 mg x L(-1), under every other concentrations of MSF, there was no marked difference among MSF-treated, Ginger-treated and untreated melanocytes (P < 0.05) when adhesion test were studied. But to migration, even at 10 mg x L(-1) MSF, there was obvious increased migration compared with MSF-untreated or Ginger-treated melanocytes (P < 0.01).
  
  
  CONCLUSIONS
  MSF has effect on melanocyte adhesion and migration, which can explain, in part, the capacity of MSF to modulate melanocyte function in vitiligo lesions.
authors.affiliation: Department of Dermatology, First Hospital of Xi' an Jiaotong University, Xi' an 710061, China. moukuanhou@sohu.com
authors.forename: Kuan-hou
authors.initials: KH
authors.lastname: Mou
authors.forename: Xian-qi
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Yu
authors.forename: Ai-ming
authors.initials: AM
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Feng
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D020939:Zingiber officinale / Q000737:chemistry; D006801:Humans; D008544:Melanocytes / Q000166:cytology / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry; D029907:Psoralea / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal