title: Evaluation of lung volumetry using dynamic three-dimensional magnetic resonance imaging.
abstract: OBJECTIVE
  We sought to investigate lung volume and surface measurements during the breathing cycle using dynamic three-dimensional magnetic resonance imaging (3D MRI).
  
  
  METHODS
  Breathing cycles of 20 healthy volunteers were examined using a 2D trueFISP sequence (3 images/second) in combination with a model and segmented 3D FLASH sequence (1 image/second) MR images using view sharing. Segmentation was performed semiautomatically using an interactive region growing technique. Vital capacity (VC) was calculated from MRI using the model (2D) and counting the voxels (3D) and was compared with spirometry.
  
  
  RESULTS
  VC from spirometry was 4.9+/-0.9 L, 4.4+/-1.2 L from 2D MRI measurement, and 4.7+/-0.9 L for 3D MRI. Using the 3D technique, correlation to spirometry was higher than using the 2D technique (r>0.95 vs. r>0.83). Using the 3D technique, split lung volumes and lung surface could be calculated. There was a significant difference between the left and right lung volume in expiration (P<0.05).
  
  
  CONCLUSIONS
  Dynamic 3D MRI is a noninvasive tool to evaluate split lung volumes and lung surfaces during the breathing cycle with a high correlation to spirometry.
authors.affiliation: Department of Radiology, German Cancer Research Center, Heidelberg, Germany. c.plathow@dkfz.de
authors.forename: Christian
authors.initials: C
authors.lastname: Plathow
authors.forename: Max
authors.initials: M
authors.lastname: Schoebinger
authors.forename: Christian
authors.initials: C
authors.lastname: Fink
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ley
authors.forename: Michael
authors.initials: M
authors.lastname: Puderbach
authors.forename: Monika
authors.initials: M
authors.lastname: Eichinger
authors.forename: Michael
authors.initials: M
authors.lastname: Bock
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Meinzer
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
mesh_terms: D000328:Adult; D003964:Diaphragm / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012119:Respiration; D013147:Spirometry; D035441:Thoracic Wall / Q000033:anatomy & histology; D014797:Vital Capacity