title: Oxaziridine-mediated amination of primary amines: scope and application to a one-pot pyrazole synthesis.
abstract: Electrophilic amination of primary aliphatic and aromatic amines is reported using a diethylketomalonate-derived oxaziridine to afford the corresponding N-Boc hydrazines in good to excellent yields. The method allows a one-pot synthesis of pyrazoles from primary amines. [Reaction: see text]
authors.affiliation: Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, U.K. a.armstrong@imperial.ac.uk
authors.forename: Alan
authors.initials: A
authors.lastname: Armstrong
authors.forename: Lyn H
authors.initials: LH
authors.lastname: Jones
authors.forename: Jamie D
authors.initials: JD
authors.lastname: Knight
authors.forename: Richard D
authors.initials: RD
authors.lastname: Kelsey
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D001388:Aziridines / Q000737:chemistry*; D006834:Hydrazines; D008958:Models, Molecular; D011720:Pyrazoles / Q000138:chemical synthesis*; D012997:Solvents
chemical_list: D000588:Amines; D001388:Aziridines; D006834:Hydrazines; D011720:Pyrazoles; D012997:Solvents