title: [Angiotensin converting enzyme, NO-synthase, and endothelin-1 genes and left ventricular hypertrophy in natives of Yakutia with hypertensive disease].
abstract: Association of polymorphic markers G7831A of ACE gene, Lys198Asn of endothelin-1 (EDN1) gene, and 4a/4b of NOS3 gene with characteristics of structure and function of the left ventricle was studied in 70 (31 men and 39 women) natives of Yakutia with hypertension. Mean age of patients was 48.3+/-0.74 years, duration of hypertension -- 12.4+/-0.99 years; 60 (85.7%), 7 (10%) and 3 (4.3%) patients had III, II and I degree of hypertension, respectively. Polymerase chain reaction was used for identification of alleles of polymorphic markers G7831A of ACE gene, Lys198Asn of EDN1 gene, and 4a/4b of NOS3 gene. Polymorphic marker G7831A of ACE gene was not associated with severity of hypertrophy of left ventricular myocardium as well as with state of systolic and diastolic left ventricular function. Patients with allele Asn of EDN1 gene in the genotype had significantly lower value of peak A integral of trans-mitral blood flow. Patients with allele 4a of NOS3 gene had thicker left ventricular walls, greater left ventricular myocardial mass and mass index.
authors.forename: L O
authors.initials: LO
authors.lastname: Minushkina
authors.forename: I R
authors.initials: IR
authors.lastname: Petrova
authors.forename: T A
authors.initials: TA
authors.lastname: Romanova
authors.forename: V V
authors.initials: VV
authors.lastname: Antipina
authors.forename: E R
authors.initials: ER
authors.lastname: Makarova
authors.forename: D A
authors.initials: DA
authors.lastname: Zateĭshikov
authors.forename: V V
authors.initials: VV
authors.lastname: Nosikov
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
mesh_terms: D000328:Adult; D000409:Alanine; D001216:Asparagine; D001783:Blood Flow Velocity; D019332:Endothelin-1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005998:Glycine; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000201:enzymology / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000201:enzymology / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008239:Lysine; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D019001:Nitric Oxide Synthase / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012426:Russia; D012720:Severity of Illness Index
chemical_list: D019332:Endothelin-1; D001216:Asparagine; D019001:Nitric Oxide Synthase; D007703:Peptidyl-Dipeptidase A; D008239:Lysine; D000409:Alanine; D005998:Glycine