Syntheses and antibacterial activity of a series of 3-(pyridine-3-yl)-2-oxazolidinone.
The syntheses of substituted piperazinyl pyridyl oxazolidinones 8-16 are described. Their in vitro activities against Gram-positive organisms such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus and enterococcus were evaluated by minimum inhibitory concentration (MIC) determination. Compound 8 and 10 were found to be superior to linezolid.
Cui
Yingjie
Y
Laboratoire de Pharmacochimie Moléculaire et Systèmes Membranaires, Université Paris 7-Denis Diderot, 75251 Paris cedex 05, France. yingjie.cui@paris7.jussieu.fr
Dang
Yaxian
Y
Yang
Yushe
Y
Zhang
Shuhua
S
Ji
Ruyun
R
D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016983:Enterococcus / Q000187:drug effects; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D011725:Pyridines; D000069349:Linezolid; C023666:pyridine