[The similarities between the mechanism of wound healing and tumor development--literature review on the occasion of a patient with colonic adenocarcinoma metastasis in a dog-bite wound].
For more than a century, the role of wound healing in the growth of tumours has been implied based on observations in experimental and clinical studies. In the recent 10-15 years processes such as cell adhesion, angiogenesis, metastatic cascade and growth factors (fe: EGF, TGF-alpha, TGF-beta, IGF-1, IGF-II, PDGF) have been identified to play key roles in different stages of wound healing as well as in tumor progression. Experimental and clinical studies have established that wound healing creates a suitable environment favouring tumour growth and metastatic potential. Based on these observations, the clinical relevance of surgical procedures comes up, may playing a role in tumor recurrence after primary resection for cancer. This makes the opportunity of the development of completely new targeted approaches (antiangiogenic therapy, dormancy therapy) for the treatment of cancer. This review article is based on a case report of a 63-year-old female patient who had colonic adenocarcinoma metastasis of the hand after biting by a dog.
Mátrai
Zoltán
Z
Országos Onkológiai Intézet, Budapest. matraidok@freemail.hu
Péley
Gábor
G
Rényi Vámos
Ferenc
F
Farkas
Emil
E
Kovács
Tibor
T
Köves
István
I
D000230:Adenocarcinoma / Q000378:metabolism / Q000503:physiopathology / Q000556:secondary*; D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis; D001733:Bites and Stings / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D004285:Dogs; D005260:Female; D006133:Growth Substances / Q000378:metabolism; D006225:Hand; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D014945:Wound Healing
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D015815:Cell Adhesion Molecules; D006133:Growth Substances; D007155:Immunologic Factors