Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma.
Six furanogermacrane sesquiterpenes, pseudoneolinderane (1), linderalactone (2), zeylanidine (3), zeylanicine (4), deacetylzeylanidine (5), and neolitrane (6), isolated from the stems of Neolitsea parvigemma, were tested for anti-inflammatory activities. Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB. The IC50 of 1 and 2 were found to be 3.21 and 8.48 microg/mL, respectively.
Chen
Keh-Shaw
KS
Tajen Institute of Technology, Ping Tung Hsien 907, Taiwan.
Hsieh
Pei-Wen
PW
Hwang
Tsong-Long
TL
Chang
Fang-Rong
FR
Wu
Yang-Chang
YC
D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D019770:Lauraceae / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D013481:Superoxides / Q000032:analysis
D000893:Anti-Inflammatory Agents; D012717:Sesquiterpenes; D013481:Superoxides