title: A rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by 1,n-alkane-di-N-butylcarbamates.
abstract: Alkane-1-N-butylcarbamate-n-ols (1-7) and 1,n-alkane-di-N-butylcarbamates (8-14) are potent pseudo-substrate inhibitors of acetylcholinesterase. For inhibitors 1-7, the pre-steady state -logK(s) values and steady state -logK(i), values are linearly correlated with the tether length (N). However, for inhibitors 8-14, correlation of the -logK(s) or -logK(i) values against N deviates from linearity. A discontinuity of the -logK(s) versus N plot, concave downwards, is indicative of a rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by inhibitors 8-14.
authors.affiliation: Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan. gilin@dragon.nchu.edu
authors.forename: Gialih
authors.initials: G
authors.lastname: Lin
authors.forename: Hsin-Chang
authors.initials: HC
authors.lastname: Tseng
authors.forename: Ai-Chi
authors.initials: AC
authors.lastname: Chio
authors.forename: Tsao-Ming
authors.initials: TM
authors.lastname: Tseng
authors.forename: Bo-Yi
authors.initials: BY
authors.lastname: Tsai
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects / Q000378:metabolism*; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008956:Models, Chemical
chemical_list: D002219:Carbamates; D002800:Cholinesterase Inhibitors; D000110:Acetylcholinesterase