title: [A study on risk of malignant neoplasm and environmental exposure to crocidolite].
abstract: OBJECTIVE
  To explore the risk of developing malignant neoplasm in a cohort with the history of environmental exposure to crocidolite asbestos.
  
  
  METHODS
  A retrospective cohort and follow-up study covering 15 years (1987 --> 1995 --> 2001) was carrid out in a small town in Yunnan province. The cohort comprised 6254 local inhabitants. The deaths from and the RR of asbestos-related malignant neoplasms were studied.
  
  
  RESULTS
  There were 186 deaths from neoplasms in the observation group, the mortality being 2160.5 per 10(6) person-years (RR=1.293, 95%CI: 1.032-1.618), 20 of those deaths were caused by mesothelioma, with a crude mortality of 232.3 per 10(6) person-years (RR=17.929; 95%CI: 2.406-133.592). The mortalities for men and women were 267.5 and 186.7 per 10(6) person-years respectively. The crude mortality from lung cancer (56 deaths) was 650.5 per 10(6) person-years,there is no significance between the two groups (RR=1.434; 95%CI: 0.968-2.486). The difference in mortality from gastrointestinal cancer between the two groups is not significant, whereas the risk of man intestinal cancer in the observation is significant (RR=3.71; 95%CI: 1.077-13.270).
  
  
  CONCLUSIONS
  The risk of developing mesothelioma is significantly increased in the population with environmental exposure to crocidolite. The risk of man intestinal cancer in the town awaits additional studies.
authors.affiliation: Department of Occupational Medicine, West China School of Public Health, Sichuan University, Chengdu 610041, China.
authors.forename: Su-qiong
authors.initials: SQ
authors.lastname: Luo
authors.forename: Shi-hui
authors.initials: SH
authors.lastname: Mu
authors.forename: Jin-tao
authors.initials: JT
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qi-bang
authors.initials: QB
authors.lastname: Wen
authors.forename: Shan-pu
authors.initials: SP
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D017638:Asbestos, Crocidolite / Q000009:adverse effects*; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D008297:Male; D008654:Mesothelioma / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D017638:Asbestos, Crocidolite