title: Comparison of fine-scale recombination rates in humans and chimpanzees.
abstract: We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite approximately 99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.
authors.affiliation: Department of Molecular Biology and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114-2622, USA.
authors.forename: Wendy
authors.initials: W
authors.lastname: Winckler
authors.forename: Simon R
authors.initials: SR
authors.lastname: Myers
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Richter
authors.forename: Robert C
authors.initials: RC
authors.lastname: Onofrio
authors.forename: Gavin J
authors.initials: GJ
authors.lastname: McDonald
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Bontrop
authors.forename: Gilean A T
authors.initials: GA
authors.lastname: McVean
authors.forename: Stacey B
authors.initials: SB
authors.lastname: Gabriel
authors.forename: David
authors.initials: D
authors.lastname: Reich
authors.forename: Peter
authors.initials: P
authors.lastname: Donnelly
authors.forename: David
authors.initials: D
authors.lastname: Altshuler
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000235:genetics; D033481:Chromosomes, Mammalian / Q000235:genetics; D019143:Evolution, Molecular; D016678:Genome; D015894:Genome, Human; D005838:Genotype; D005914:Globins / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008390:Markov Chains; D009010:Monte Carlo Method; D002679:Pan troglodytes / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid
chemical_list: D006680:HLA Antigens; D005914:Globins