title: Fine-tuning furan toxicity: fast and quantitative DNA interchain cross-link formation upon selective oxidation of a furan containing oligonucleotide.
abstract: Oligonucleotides containing a furan modified internal nucleoside have been synthesized; selective in situ oxidation of the furan moiety to a reactive enal species in the presence of a complementary DNA strand gives rise to fast and efficient formation of an interstrand cross-link.
authors.affiliation: Laboratory for Organic and Biomimetic Chemistry, Department of Organic Chemistry, Krijgslaan 281, S4, 9000, Gent, Belgium.
authors.forename: Sami
authors.initials: S
authors.lastname: Halila
authors.forename: Trinidad
authors.initials: T
authors.lastname: Velasco
authors.forename: Pierre De
authors.initials: PD
authors.lastname: Clercq
authors.forename: Annemieke
authors.initials: A
authors.lastname: Madder
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D008968:Molecular Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D003432:Cross-Linking Reagents; D005663:Furans; D009841:Oligonucleotides; D004247:DNA