A rat model of neurolathyrism: repeated injection of L: -beta-ODAP induces the paraparesis of the hind legs.
Neurolathyrisim is a motor neuron disease characterized by spastic paraparesis in the hind legs, and is caused by grass pea, Lathyrus sativus, which contains the excitotoxic amino acid, 3-N-oxalyl-L: -2,3-diaminopropanoic acid (L: -beta-ODAP), an alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamatergic receptor agonist. In an attempt to make a useful model of this disease, the CNS distribution and toxicity of L: -beta-ODAP was studied in rat neonates after parenteral administration. L: -beta-ODAP was detected in the spinal cord as well as in the pons/medulla oblongata, though only small amounts in the latter. Repeated injection of L: -beta-ODAP resulted in rats with paraparesis of the legs, though at a low incidence rate of 0.032. These paralyzed rats displayed the severe atrophy of the ventral root of the lumbar cord as well as degenerations of motor neuron. The rats were useful models for the study of motor neuron degeneration in the spinal cord.
Kusama-Eguchi
K
K
Laboratory of Biology, Nihon University College of Pharmacy, Narashinodai, Funabashi, Japan. kusamak@pha.nihon-u.ac.jp
Ikegami
F
F
Kusama
T
T
Suda
A
A
Ogawa
Y
Y
Igarashi
K
K
Watanabe
K
K
D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D018690:Excitatory Amino Acid Agonists / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D007263:Infusions, Parenteral; D007842:Lathyrism / Q000139:chemically induced; D027807:Lathyrus / Q000737:chemistry; D035002:Lower Extremity / Q000294:innervation / Q000473:pathology; D008526:Medulla Oblongata / Q000378:metabolism / Q000473:pathology; D020335:Paraparesis / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017470:Receptors, Glutamate / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology; D015091:beta-Alanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity
C510363:3-N-oxalyl-L -2,3-diaminopropanoic acid; D018690:Excitatory Amino Acid Agonists; D017470:Receptors, Glutamate; D015091:beta-Alanine