title: Hyperpolarized 3He lung imaging at 0.5 and 1.5 Tesla: a study of susceptibility-induced effects.
abstract: Hyperpolarized (3)He MRI of the human lung was performed at 0.54 and 1.5 T using identical software and hardware (except for RF coils) at both field strengths. The T(*) (2) of (3)He gas in the lung was measured, and the effects of magnetic-susceptibility-induced field inhomogeneities on the appearance of interleaved-spiral and interleaved-echo-planar lung images at 1.5 T were compared to those at 0.54 T. Mean T(*) (2) values for (3)He gas in the healthy human lung were 26.8 +/- 1.5 ms and 67.9 +/- 1.3 ms at 1.5 and 0.54 T, respectively. At 0.54 T, interleaved-spiral images showed markedly less blurring due to susceptibility effects compared to images acquired at 1.5 T. At both 0.54 and 1.5 T, interleaved-echo-planar images appeared essentially identical to corresponding GRE images, even though the data-sampling period per echo and echo time were substantially longer for the interleaved-echo-planar images acquired at 0.54 T.
authors.affiliation: Center for In-vivo Hyperpolarized Gas MR Imaging, Department of Radiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Salerno
authors.forename: James R
authors.initials: JR
authors.lastname: Brookeman
authors.forename: Eduard E
authors.initials: EE
authors.lastname: de Lange
authors.forename: John P
authors.initials: JP
authors.lastname: Mugler
mesh_terms: D017352:Echo-Planar Imaging; D006371:Helium; D006801:Humans; D007554:Isotopes; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods
chemical_list: D007554:Isotopes; D006371:Helium