Effect of IL-6 promoter polymorphism on incidence and outcome in Hodgkin's lymphoma.
A single nucleotide polymorphism (SNP) is present at position -174 of the human interleukin-6 gene. The risk of developing Hodgkin's lymphoma (HL) in young adults decreases with an increasing number of C alleles at this position. We analysed the effect of this SNP on incidence and outcome in HL. DNA samples from 408 cases and 349 controls were screened and analysed following stratification by age, histological subtype and Epstein-Barr virus status. Although the risk of classical HL in young adults decreased with increasing C alleles, case-control differences were not significant. An excess of G alleles was observed for nodular lymphocyte predominant HL in young adults (n = 21), which was significant.
Cordano
Pablo
P
LRF Virus Centre, Institute of Comparative Medicine, University of Glasgow, Glasgow G61 1QH, UK. p.cordano@vet.gla.ac.uk
Lake
Annette
A
Shield
Lesley
L
Taylor
G M
GM
Alexander
Freda E
FE
Taylor
Penelope R A
PR
White
Jo
J
Jarrett
Ruth F
RF
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D004273:DNA, Neoplasm / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D005838:Genotype; D006689:Hodgkin Disease / Q000235:genetics* / Q000821:virology; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics*
D004273:DNA, Neoplasm; D015850:Interleukin-6