[Diabetic microangiopathy: vascular cell crosstalk in hyperglycaemia].
Diabetic retinopathy is the most common microvascular complication in diabetes mellitus, mostly determined by chronic glycaemia as measured by HbA1c. The sequence of events involves changes in the cellular crosstalk of the retinal capillary, initiated by the loss of intramural pericytes. Data from transgenic and diabetic models allow to assess the relative importance of this phenomenon. New insight into biochemical and cell biological interactions from hyperglycaemia to vascular injury establish metabolic signal blockers as novel therapeutic approaches for diabetic microangiopathy.
Hammes
H-P
HP
5. Medizinische Klinik, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim. hans-peter.hammes@med5.ma.uni-heidelberg.de
D000818:Animals; D030801:Animals, Genetically Modified; D002196:Capillaries / Q000503:physiopathology; D002199:Capillary Permeability; D002450:Cell Communication; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D006801:Humans; D020286:Pericytes / Q000502:physiology; D012171:Retinal Vessels / Q000503:physiopathology