Local design principles of mammalian cortical networks.
To understand global and local design principles of mammalian cerebral cortical networks, we applied network-theoretical approaches to connectivity data from macaque and cat cortical networks. We first confirmed "small-world" properties and searched for the evidence of hierarchical modularity. To elucidate their local design principles, we then compared these cortical networks, based on the significance profile (SP) of network motifs in the real network compared to randomized networks. We found that SPs of different mammalian cortical networks are highly conserved and robust, suggesting constraints of neocortical development and evolution.
Sakata
Shuzo
S
Division of Brain Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki 4448585, Japan.
Komatsu
Yusuke
Y
Yamamori
Tetsuo
T
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D003198:Computer Simulation; D006801:Humans; D008251:Macaca; D009415:Nerve Net / Q000502:physiology*; D016571:Neural Networks, Computer