title: The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator CsrA.
abstract: A gene in Legionella pneumophila that has significant homology to published hfq genes demonstrated regulation by RpoS and the transcriptional regulator LetA. Additionally, Hfq has a positive effect on the presence of transcripts of the genes for CsrA and the ferric uptake regulator Fur. Mutants lacking hfq demonstrate defects in growth and pigmentation and slight defects in virulence in both amoeba and macrophage infection models. Hfq appears to play a major role in exponential-phase regulatory cascades of L. pneumophila.
authors.affiliation: Department of Medical Microbiology and Hygiene, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany. tamara.mcnealy@medizin.uni-ulm.de
authors.forename: Tamara L
authors.initials: TL
authors.lastname: McNealy
authors.forename: Vera
authors.initials: V
authors.lastname: Forsbach-Birk
authors.forename: Chunwei
authors.initials: C
authors.lastname: Shi
authors.forename: Reinhard
authors.initials: R
authors.lastname: Marre
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism* / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D035001:Host Factor 1 Protein / Q000096:biosynthesis / Q000378:metabolism*; D016952:Legionella pneumophila / Q000502:physiology*; D010858:Pigmentation / Q000235:genetics; D011485:Protein Binding; D012329:RNA, Bacterial; D012333:RNA, Messenger / Q000032:analysis; D012097:Repressor Proteins / Q000378:metabolism*; D017384:Sequence Deletion; D012808:Sigma Factor / Q000502:physiology*; D014158:Transcription, Genetic; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; C068355:CcdA protein, Bacteria; C488628:CsrA protein, Legionella pneumophila; D035001:Host Factor 1 Protein; D012329:RNA, Bacterial; D012333:RNA, Messenger; D012097:Repressor Proteins; D012808:Sigma Factor; C068477:ferric uptake regulating proteins, bacterial; C069567:sigma factor KatF protein, Bacteria