title: Low-grade renal collecting duct carcinoma. A case report with histochemical, immunohistochemical, and ultrastructural study.
abstract: We report a rare tumor called low-grade renal collecting duct carcinoma. Grossly, the tumor consisted of multiple cysts and solid white nodules, measuring 10 cm in diameter and occupying most of the renal parenchyma. Histologically, the tumor was characterized by well-differentiated tubules lined by eosinophilic cells without papillary projections, abundant predominantly extracellular mucin, minimal cellular atypia, no desmoplasia, and rare mitoses. This tumor occurs in collecting ducts and the tumor cells were positive for epithelial membrane antigen, high-molecular-weight keratin, CD15, and mitochondrial antibody and negative for CD10. Few cells stained weakly positive for ulex europaeus. Ultrastructural study showed a large number of mitochondria according to the eosinophilic cells seen in light microscopy.
authors.affiliation: Department of Nephrology, B. Rappaport Facluty of Medicine, Nahariya Hospital, Technion, Nahariya, 22100, Israel. raymondfarah@hotmail.com
authors.forename: Raymond
authors.initials: R
authors.lastname: Farah
authors.forename: Ofer
authors.initials: O
authors.lastname: Ben-Izhak
authors.forename: Mariana
authors.initials: M
authors.lastname: Munichor
authors.forename: Hector
authors.initials: H
authors.lastname: Cohen
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D007685:Kidney Tubules, Collecting / Q000737:chemistry / Q000473:pathology*; D016256:Lewis X Antigen / Q000032:analysis; D008297:Male; D008871:Microvilli / Q000648:ultrastructure; D008928:Mitochondria / Q000276:immunology; D018396:Mucin-1 / Q000032:analysis
chemical_list: D001323:Autoantibodies; D014408:Biomarkers, Tumor; D016256:Lewis X Antigen; D018396:Mucin-1