Statistical design and analysis of pharmacogenetic trials.
Pharmacogenetic trials investigate the effect of genotype on treatment response. When there are two or more treatment groups and two or more genetic groups, investigation of gene-treatment interactions is of key interest. However, calculation of the power to detect such interactions is complicated because this depends not only on the treatment effect size within each genetic group, but also on the number of genetic groups, the size of each genetic group, and the type of genetic effect that is both present and tested for. The scale chosen to measure the magnitude of an interaction can also be problematic, especially for the binary case. Elston et al. proposed a test for detecting the presence of gene-treatment interactions for binary responses, and gave appropriate power calculations. This paper shows how the same approach can also be used for normally distributed responses. We also propose a method for analysing and performing sample size calculations based on a generalized linear model (GLM) approach. The power of the Elston et al. and GLM approaches are compared for the binary and normal case using several illustrative examples. While more sensitive to errors in model specification than the Elston et al. approach, the GLM approach is much more flexible and in many cases more powerful.
Kelly
Patrick J
PJ
Medical and Pharmaceutical Statistics Research Unit, The University of Reading, Reading RG6 6FN, UK. patrick.kelly@reading.ac.uk
Stallard
Nigel
N
Whittaker
John C
JC
D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D006801:Humans; D016014:Linear Models; D015233:Models, Statistical; D010597:Pharmacogenetics / Q000706:statistics & numerical data*; D018401:Sample Size; D006113:United Kingdom