Renal handling of endothelin in patients with chronic heart failure.
Chronic heart failure is characterized by increased renal extraction of endothelin (ET)-1 and unaltered handling of big ET-1. The renal extraction of ET-1 in patients with heart failure is closely related to elevations in pulmonary artery and pulmonary capillary wedge pressures.
Al-Hesayen
Abdul
A
Division of Cardiology, Department of Medicine, Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada.
Parker
John D
JD
D001794:Blood Pressure / Q000502:physiology; D016232:Endothelins / Q000097:blood*; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000378:metabolism* / Q000503:physiopathology; D008875:Middle Aged; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D012079:Renal Circulation / Q000502:physiology
D016232:Endothelins