Temporal and spatial patterning of an organ by a single transcription factor.
During the formation of animal organs, a single regulatory factor can control the majority of cell-fate decisions, but the mechanisms by which this occurs are poorly understood. One such regulator, the nematode transcription factor PHA-4, functions together with various cis-regulatory elements in target genes to regulate spatial and temporal patterning during development of the pharynx.
Banerjee
Diya
D
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
Slack
Frank J
FJ
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D008957:Models, Genetic; D038081:Organogenesis / Q000235:genetics; D010614:Pharynx / Q000196:embryology / Q000378:metabolism; D050436:Regulatory Elements, Transcriptional; D015534:Trans-Activators / Q000502:physiology*; D014158:Transcription, Genetic
D029742:Caenorhabditis elegans Proteins; C113277:Pha-4 protein, C elegans; D015534:Trans-Activators