title: High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania.
abstract: Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.
authors.affiliation: Centre for International Health, University of Bergen, N-5021 Bergen, Norway. bjorn.blomberg@cih.uib.no
authors.forename: Bjørn
authors.initials: B
authors.lastname: Blomberg
authors.forename: Roland
authors.initials: R
authors.lastname: Jureen
authors.forename: Karim P
authors.initials: KP
authors.lastname: Manji
authors.forename: Bushir S
authors.initials: BS
authors.lastname: Tamim
authors.forename: Davis S M
authors.initials: DS
authors.lastname: Mwakagile
authors.forename: Willy K
authors.initials: WK
authors.lastname: Urassa
authors.forename: Maulidi
authors.initials: M
authors.lastname: Fataki
authors.forename: Viola
authors.initials: V
authors.lastname: Msangi
authors.forename: Marit G
authors.initials: MG
authors.lastname: Tellevik
authors.forename: Samwel Y
authors.initials: SY
authors.lastname: Maselle
authors.forename: Nina
authors.initials: N
authors.lastname: Langeland
mesh_terms: D016470:Bacteremia / Q000382:microbiology / Q000401:mortality*; D002675:Child, Preschool; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000472:pathogenicity; D004756:Enterobacteriaceae Infections / Q000382:microbiology / Q000401:mortality*; D004926:Escherichia coli / Q000201:enzymology / Q000472:pathogenicity; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000472:pathogenicity; D008297:Male; D019779:Salmonella enterica / Q000145:classification / Q000201:enzymology / Q000472:pathogenicity; D013636:Tanzania / Q000453:epidemiology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: C107198:beta-lactamase SHV-12; D001618:beta-Lactamases