title: Sustained viral suppression and immune recovery in HIV type 1-infected children after 4 years of highly active antiretroviral therapy.
abstract: We report the data from a long-term study of 31 human immunodeficiency virus type 1 (HIV-1)-infected children who were treated with highly active antiretroviral therapy. A high proportion of the children had undetectable HIV-1 RNA levels. CD4+ T cell counts recovered and remained stable. Adverse events were observed frequently but were mostly mild.
authors.affiliation: Department of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: Pieter L A
authors.initials: PL
authors.lastname: Fraaij
authors.forename: Gwenda
authors.initials: G
authors.lastname: Verweel
authors.forename: Annemarie M C
authors.initials: AM
authors.lastname: van Rossum
authors.forename: Ellen G
authors.initials: EG
authors.lastname: van Lochem
authors.forename: Martin
authors.initials: M
authors.lastname: Schutten
authors.forename: Corry M R
authors.initials: CM
authors.lastname: Weemaes
authors.forename: Nico G
authors.initials: NG
authors.lastname: Hartwig
authors.forename: David M
authors.initials: DM
authors.lastname: Burger
authors.forename: Ronald
authors.initials: R
authors.lastname: de Groot
mesh_terms: D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012367:RNA, Viral / Q000097:blood*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D012367:RNA, Viral