Equine herpesvirus 1 utilizes a novel herpesvirus entry receptor.
The well-described herpesvirus entry receptors HveA (TNFRSF14), HveB (nectin 2), and HveC (nectin 1) have been shown to mediate the entry of alphaherpesviruses. Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficiently entered and replicated in CHO-K1 cells that lack the entry receptors HveA, HveB, and HveC, demonstrating that EHV-1 utilizes a unique entry receptor. As with other alphaherpesviruses, efficient EHV-1 entry was dependent on glycoprotein D and cell surface glycosaminoglycans.
Frampton
Arthur R
AR
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1246 Biomedical Science Tower, Pittsburgh, PA 15261, USA.
Goins
William F
WF
Cohen
Justus B
JB
von Einem
Jens
J
Osterrieder
Nikolaus
N
O'Callaghan
Dennis J
DJ
Glorioso
Joseph C
JC
D000818:Animals; D016466:CHO Cells; D002522:Chlorocebus aethiops; D006224:Cricetinae; D006025:Glycosaminoglycans / Q000502:physiology; D006566:Herpesviridae Infections / Q000209:etiology / Q000662:veterinary / Q000821:virology; D004861:Herpesvirus 1, Equid / Q000472:pathogenicity* / Q000502:physiology*; D006734:Horse Diseases / Q000209:etiology / Q000821:virology; D006736:Horses; D011991:Receptors, Virus / Q000502:physiology*; D014709:Vero Cells; D014759:Viral Envelope Proteins / Q000502:physiology
D006025:Glycosaminoglycans; D011991:Receptors, Virus; D014759:Viral Envelope Proteins; C488988:glycoprotein D, Equid herpesvirus 1