[Effects of genistein on the proliferation and lipid peroxidation of rat aortic smooth muscle cells].
OBJECTIVE
To investigate the effect of genistein on the proliferation and lipid peroxidation of rat aortic smooth muscle cells (SMC).


METHODS
Different concentrations of genistein were used to inhibit the proliferation of smooth muscle cells, and SOD, MDA, cAMP, 6-Keto-PGF1a in medium were observed. MTT method was used to assay the proliferation of SMC.


RESULTS
Compared with the control group, 0.1-100 micromol/L genistein could inhibit the proliferation of SMC by increasing SOD activity, raising cAMP and 6-Keto-PGF1a, reducing MDA (P<0.05, P<0.01), and the inhibitory action accompanied with the dose-effect relation.
Cui
Zaiwu
Z
Institute of Integrated Chinese Traditional and Western Medicine, Hebei Medical University, Shijiazhuang 050017.
Ge
Xizhen
X
Li
En
E
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D019833:Genistein / Q000494:pharmacology*; D007529:Isoflavones / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max / Q000737:chemistry
D000975:Antioxidants; D007529:Isoflavones; D019833:Genistein