title: Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia.
abstract: BACKGROUND
  The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia.
  
  
  METHODS
  We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.
authors.affiliation: Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil. stella@hemato.epm.br
authors.forename: Maria Stella
authors.initials: MS
authors.lastname: Figueiredo
authors.forename: Perla
authors.initials: P
authors.lastname: Vicari
authors.forename: Eliza Yuriko Sugano
authors.initials: EY
authors.lastname: Kimura
authors.forename: Sandra Vallin
authors.initials: SV
authors.lastname: Antunes
authors.forename: Mihoko
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000208:Acute Disease; D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood / Q000150:complications*; D017809:Fatal Outcome; D006447:Hemoglobin H; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000209:etiology*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications; D013997:Time Factors
chemical_list: D006447:Hemoglobin H