title: Severe neuroborreliosis: The benefit of prolonged high-dose combination of antimicrobial agents with steroids--an illustrative case.
abstract: Neuroborreliosis frequently occurs in endemic areas, whereas encephalomyelitis is uncommon. Treatment consists classically of 2 to 4 weeks of recommended antimicrobial agents with a generally good outcome. A severe case is reported combining an encephalomyelitis with an axonal polyneuropathy. Clinical improvement was observed only with the use of prolonged high dose of 2 antimicrobial agents combined with steroids.
authors.affiliation: Department of Neurology, Centre Hospitalier de Mont de Marsan, 40000 Mont de Marsan, France. massengoserge@hotmail.com
authors.forename: Serge Aurelien
authors.initials: SA
authors.lastname: Massengo
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bonnet
authors.forename: Carine
authors.initials: C
authors.lastname: Braun
authors.forename: Anne
authors.initials: A
authors.lastname: Vital
authors.forename: Jacques
authors.initials: J
authors.lastname: Beylot
authors.forename: Jean
authors.initials: J
authors.lastname: Bastard
mesh_terms: D000328:Adult; D025065:Borrelia burgdorferi / Q000187:drug effects* / Q000302:isolation & purification; D002443:Ceftriaxone / Q000627:therapeutic use; D003287:Contrast Media; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D002443:Ceftriaxone; D004318:Doxycycline; D008775:Methylprednisolone