title: The use of a short-acting benzodiazepine to reduce the risk of syncopal episodes during upright stereotactic breast biopsy.
abstract: The use of sublingual lorazepam provides a safe and effective means of reducing the risk of syncopal episodes during upright stereotactic breast biopsy. Sublingual lorazepam, 2-4mg, was received by 19 women undergoing a total of 20 stereotactic procedures. Of 14 women who had previously fainted during upright stereotactic biopsy, 13 had a successful repeat biopsy following administration of sublingual lorazepam. All 4 women who received lorazepam for significant anxiety had successful biopsies. Stereotactic guided wire localization also was performed in 2 cases.
authors.affiliation: Breast Institute, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK. jjames3@ncht.trent.nhs.uk
authors.forename: J J
authors.initials: JJ
authors.lastname: James
authors.forename: A R M
authors.initials: AR
authors.lastname: Wilson
authors.forename: A J
authors.initials: AJ
authors.lastname: Evans
authors.forename: H
authors.initials: H
authors.lastname: Burrell
authors.forename: E J
authors.initials: EJ
authors.lastname: Cornford
authors.forename: L J
authors.initials: LJ
authors.lastname: Hamilton
mesh_terms: D000286:Administration, Sublingual; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy*; D044963:Biopsy, Fine-Needle / Q000379:methods; D001941:Breast Diseases / Q000473:pathology*; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage* / Q000627:therapeutic use; D011187:Posture; D013238:Stereotaxic Techniques; D013575:Syncope / Q000517:prevention & control*
chemical_list: D014151:Anti-Anxiety Agents; D008140:Lorazepam