Synthesis and characterization of thiomers of polyaspartamide type.
Synthesis of poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-thioglycolic acid (PHEA-TGA) conjugate as a new polyaspartamide thiomer is described. The parent polymer PHEA is chemically modified by introducing sulphydryl-bearing compound thioglycolic acid. By varying the reaction conditions several batches of PHEA-TGA conjugates were prepared and analyzed. Tensile studies revealed that total work of adhesion of PHEA-TGA increased more than twice compared to the unmodified polymer. Microparticles prepared from the thiolated polymer preserved its bioadhesive properties.
Bilicić
M Bubenik
MB
PLIVA-Research Institute, Ltd., Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia.
Filipović-Grcić
J
J
Martinac
A
A
Barbarić
M
M
Zorc
B
B
Cetina-Cizmek
B
B
Tudja
P
P
D002626:Chemistry, Pharmaceutical / Q000379:methods; D010316:Particle Size; D010455:Peptides / Q000032:analysis / Q000138:chemical synthesis*; D011108:Polymers / Q000032:analysis / Q000138:chemical synthesis*; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods; D013864:Thioglycolates / Q000032:analysis / Q000138:chemical synthesis*
D010455:Peptides; D011108:Polymers; D013864:Thioglycolates; C008965:alpha,beta-poly((2-hydroxyethyl)-aspartamide)