Characterization of neuropathies associated with elevated IgM serum levels.
BACKGROUND
In contrast to the IgM monoclonal gammopathies the neuropathy associated with polyclonal IgM gammopathy has not been well characterized.


OBJECTIVE
To characterize the neuropathy in patients with elevated serum IgM.


METHODS
Retrospective review.


METHODS
Academically based neuropathy center.


METHODS
45 patients with elevated quantitative immunoglobulin M were identified.


METHODS
Patients are described with regard to clinical phenotype, electrodiagnostic features of demyelination or focality, presence of IgM monoclonal gammopathy, and presence of autoantibody activity.


RESULTS
Elevated IgM levels occurred in 45 (11.5%) of 391 patients. Of these, 24 (53%) had polyclonal gammopathy and 21 (47%) had an IgM monoclonal gammopathy. Anti-nerve antibodies occurred in 14/21 (67%) of patients with monoclonal gammopathy, as compared to 1/24 (4%) with polyclonal gammopathy. Clinically, most patients in all groups had a predominantly large fiber sensory neuropathy. Thirty patients underwent electrodiagnostic testing. Of these, 22/30 (73%) fulfilled at least one published criteria for CIDP, including 92% of the monoclonal gammopathy patients and 59% of the polyclonal gammopathy patients. Fifteen of the 30 patients had evidence of focality or multifocality, with 14 of these 15 showing evidence of demyelination.


CONCLUSIONS
Monoclonal and polyclonal IgM patients have similar distributions of neuropathy phenotypes. Neuropathy in association with elevated serum IgM, with or without monoclonal gammopathy or autoantibody activity, is more likely to be demyelinating or multifocal. Serum quantitative IgM level and immunofixation in neuropathy patients may aid in identification of an immune mediated or a demyelinating component.
Goldfarb
Adina R
AR
Peripheral Neuropathy Center, Department of Neurology, Weill Medical College of Cornell University, 635 Madison Ave., Suite 400, New York, NY 10022, USA. argoldfarb@juno.com
Sander
Howard W
HW
Brannagan
Thomas H
TH
Magda
Paul
P
Latov
Norman
N
D000911:Antibodies, Monoclonal / Q000097:blood / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D004568:Electrodiagnosis; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood* / Q000276:immunology*; D009186:Myelin Sheath / Q000276:immunology / Q000473:pathology; D009413:Nerve Fibers, Myelinated / Q000276:immunology / Q000473:pathology; D010265:Paraproteinemias / Q000097:blood / Q000276:immunology; D010525:Peripheral Nerves / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D010641:Phenotype; D011129:Polyradiculoneuropathy / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015854:Up-Regulation / Q000276:immunology
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D007075:Immunoglobulin M