[EBV-associated cutaneous plasmocytoma in a renal transplant patient].
BACKGROUND
Postransplant lymphoproliferative disorders are well known complications of solid organ transplant, usually associated with Epstein-Barr virus (EBV).


METHODS
A 25 year old renal transplant patient presented with two subcutaneous nodules on the lower limb that appeared 3 years after a second renal transplantation. Biopsy of one nodule showed an EBV associated plasmocytoma located in the subcutaneous tissue. A complete systemic evaluation showed no evidence of extracutaneous involvement. The patient was treated with anti CD20 therapy (rituximab), and complete remission was achieved.


CONCLUSIONS
Extranodular localisations of postransplant lymphoproliferative disorders are usually reported, but cutaneous localizations are rarely described. Histological presentation are various, but plasmocytoma-type is infrequent. Initial therapy of cutaneous EBV-associated postransplant lymphoproliferative disorders without extracutaneous involvement consists in reduction of the immunosuppression therapy and/or an antiviral treatment and prolonged surveillance. Treatment with monoclonal anti-CD20 antibodies (rituximab) is proposed.
Carbonnelle
A
A
Services d'Anatomopathologie, Groupe Hospitalier Necker-Enfants Malades, 75743 Paris.
Mahé
E
E
Morelon
E
E
Varet
B
B
Kreis
H
H
Brousse
N
N
Fraitag
S
S
D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D010954:Plasmacytoma / Q000188:drug therapy* / Q000209:etiology / Q000821:virology*; D012074:Remission Induction; D000069283:Rituximab; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000821:virology*
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab