title: Helper-dependent adenoviral vectors for gene therapy.
abstract: Helper-dependent adenoviral vectors possess a number of characteristics that make them attractive gene therapy vectors. These vectors are completely devoid of viral coding sequences and are able to mediate high-efficiency transduction in vivo to direct sustain high-level transgene expression with negligible chronic toxicity. This review focuses on advances in helper-dependent adenoviral vector technology, selected examples of in vivo studies of particular interest, and the issue of vector-mediated acute toxicity.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Palmer
authors.forename: Philip
authors.initials: P
authors.lastname: Ng
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006378:Helper Viruses / Q000235:genetics*; D006801:Humans