[Treatment of experimental chronic bacterial prostatitis with free-radical scavenger in rats].
OBJECTIVE
To evaluate the efficacy of free-radical scavenger in the treatment of chronic bacterial prostatitis (CBP).


METHODS
Fifty-eight healthy male rats were randomly divided into a control group and four model groups (Groups A, B, C and D). The chronic prostatitis model was established in the latter groups through injecting E. coli into the ventral robe of the prostate according to document. Group A was untreated, Group B treated with free-radical scavenger vitamin C, Group C with salicylazosulfapyridine (SASP), Group D with SASP and vitamin C. Superoxide dismutase (SOD) and malondialdehyde (MDA) examinations were conducted in each group 2 months later.


RESULTS
Vitamin C could significantly increase the level of SOD and decrease the level of MDA. There was significant difference between the model groups and the control one, as well as between the treated groups and the untreated one, but none among the treated groups.


CONCLUSIONS
Free-radical scavenger may be useful for the treatment of chronic bacterial prostatitis.
Xu
Shao-bo
SB
Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China.
Li
Shi-wen
SW
Zheng
Xin-min
XM
Hu
Li-quan
LQ
D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use; D002908:Chronic Disease; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011472:Prostatitis / Q000188:drug therapy* / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012460:Sulfasalazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000378:metabolism
D016166:Free Radical Scavengers; D012460:Sulfasalazine; C024059:methylsulfasalazine; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D001205:Ascorbic Acid