1-Aryl-4,6-diamino-1,2-dihydrotriazine as antimalarial agent: a new synthetic route.
Some novel derivatives of 1-aryl-4,6-diamino-1,2-dihydrotriazines have been synthesized using neat technology under microwaves. These were tested in vitro against both sensitive and resistant Plasmodium falciparum strains for antimalarial activity.
Kidwai
M
M
Department of Chemistry, University of Delhi, Delhi 110007, India. kidwai_chemistry@yahoo.co.uk
Mothsra
P
P
Mohan
R
R
Biswas
S
S
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis*; D004351:Drug Resistance; D006801:Humans; D020128:Inhibitory Concentration 50; D010963:Plasmodium falciparum / Q000187:drug effects; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
C500294:4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine; D000962:Antimalarials; D014227:Triazines