title: No associations between Parkinson's disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genes.
abstract: Reactive oxygen species derived from dopamine metabolism can induce oxidative stress and thus may contribute to Parkinson's disease (PD) pathogenesis. The quinone oxidoreductases, nicotinamide adenine dinucleotide (phosphate) (NAD[P]H): quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH): quinone oxidoreductase 2 (NQO2) detoxify quinones and quinonoid compounds. We investigated associations of genetic polymorphisms of NQO1 (C609T) and NQO2 (I/D, 29 base pairs) with PD in a population-based case-control study of 190 idiopathic PD cases and 305 unrelated controls matched on age and sex. No associations were detected for either gene variant or for any allele combinations.
authors.affiliation: Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195-7234, USA.
authors.forename: Starlyn
authors.initials: S
authors.lastname: Okada
authors.forename: Federico M
authors.initials: FM
authors.lastname: Farin
authors.forename: Patricia
authors.initials: P
authors.lastname: Stapleton
authors.forename: Hanna
authors.initials: H
authors.lastname: Viernes
authors.forename: Sean D
authors.initials: SD
authors.lastname: Quigley
authors.forename: Karen M
authors.initials: KM
authors.lastname: Powers
authors.forename: Terri
authors.initials: T
authors.lastname: Smith-Weller
authors.forename: Gary M
authors.initials: GM
authors.lastname: Franklin
authors.forename: W T
authors.initials: WT
authors.lastname: Longstreth
authors.forename: Phillip D
authors.initials: PD
authors.lastname: Swanson
authors.forename: Harvey
authors.initials: H
authors.lastname: Checkoway
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D016017:Odds Ratio; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D011808:Quinone Reductases / Q000235:genetics*
chemical_list: D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human; C419642:NRH - quinone oxidoreductase2; D011808:Quinone Reductases