[Study on function of decoction for invigorating the kidney and improving blood circulation on rabbits blood stasis model].
OBJECTIVE
To evaluate the effect of decoction for invigorating the kidney and improving blood circulation to thrombosis on rabbits blood stasis model.


METHODS
Thirty rabbits were randomly divided into normal group, model group, heavy dose group, slight dose group and xue shuan ning group. Tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor (PAI), fibrinogen (Fbg) and D-dimer (DD) were investigated after those rabbits had been treated. One was selected randomly from each group to observe pathological changes.


RESULTS
There was significant difference in t-PA, PAI, Fbg and DD between normal group and other groups (P < 0.01). Among groups of heavy dose, slight dose, xue shuan ning and model, the statistical differences were significant, as well as among groups of heavy dose, slight dose and xue shuan ning (P < 0.05). However, there was no statistical difference between heavy dose group and slight dose group (P > 0.05). The pathological changes in model group were most serious, and those in xue shuan ning were less serious. There were slight pathological change in heavy dose group and light dose group.


CONCLUSIONS
Models were made successfully. Heavy dose group and slight dose group have stronger effect on thrombosis than xue shuan ning group.
Zhan
Xiao-ping
XP
The Second Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Lou
Jian-guo
JG
Jin
Xiao-ying
XY
Sun
Mei
M
Jin
Chen-yu
CY
Xu
Xi-hong
XH
Qin
Guang-ming
GM
Xu
Yan-qi
YQ
Bao
Jun
J
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D008516:Medicine, Chinese Traditional; D010946:Plants, Medicinal / Q000737:chemistry; D015849:Plasminogen Inactivators / Q000097:blood; D011817:Rabbits; D011897:Random Allocation; D013927:Thrombosis / Q000097:blood / Q000473:pathology*; D010959:Tissue Plasminogen Activator / Q000097:blood*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005338:Fibrin Fibrinogen Degradation Products; D015849:Plasminogen Inactivators; C036309:fibrin fragment D; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator