Resective surgery to treat refractory status epilepticus in children with focal epileptogenesis.
Prolonged high-dose suppressive therapy (HDST) is a mainstay in the management of refractory status epilepticus (RSE), albeit with high morbidity and mortality. The authors studied 10 patients who were carefully selected for epilepsy surgery after failing prolonged (>2 weeks) HDST. Status epilepticus was stopped acutely in all of them with no mortality and no substantial morbidity. At follow-up (median 7 months), 7 (70%) of 10 patients were seizure free, and 3 (30%) of 10 had significant improvement in their epilepsy.
Alexopoulos
A
A
Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Lachhwani
D K
DK
Gupta
A
A
Kotagal
P
P
Harrison
A M
AM
Bingaman
W
W
Wyllie
E
E
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000002:abnormalities; D002648:Child; D003131:Combined Modality Therapy; D004660:Encephalitis / Q000150:complications; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006423:Hemianopsia / Q000453:epidemiology; D038421:Hemispherectomy; D006801:Humans; D007223:Infant; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D008297:Male; D010291:Paresis / Q000209:etiology; D011183:Postoperative Complications; D012189:Retrospective Studies; D013226:Status Epilepticus / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000150:complications
D000927:Anticonvulsants