A geranylated biphenyl derivative from Garcinia malvgostana.
Extracts of root bark, stem bark and the latex collected from the green fruits of Garcinia mangostana gave alpha-mangostin, beta-mangostin, gamma-mangostin, garcinone-E, methoxy-beta-mangostin and a new geranylated biphenyl derivative 3-hydroxy-4-geranyl-5-methoxybiphenyl. The latex of G. mangostana consists of more than 75% of xanthones which have strong antibacterial (anti-MRSA and -VRE), anti-inflammatory, antifungal and a number of other biological activities. Hence the presence of the above highly bioactive compounds in large quantities should be the causative factor for G. mangostana's medicinal value in indigenous medicine.
Dharmaratne
H R W
HR
Natural Products Programme, Institute of Fundamental Studies, Kandy 20000, Sri Lanka. hrwd@ifs.ac.lk
Piyasena
K G N P
KG
Tennakoon
S B
SB
D001713:Biphenyl Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D029760:Garcinia / Q000737:chemistry*; D007840:Latex / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology; D044004:Xanthones / Q000302:isolation & purification* / Q000494:pharmacology
C499955:3-hydroxy-4-geranyl-5-methoxybiphenyl; D001713:Biphenyl Compounds; D007840:Latex; D013729:Terpenes; D044004:Xanthones