title: Olfactory bulb volumes in patients with idiopathic Parkinson's disease a pilot study.
abstract: Olfactory loss is among early signs of idiopathic Parkinson's disease (IPD). The present pilot study aimed to investigate whether this loss would be reflected in a decreased volume of the olfactory bulb (OB) established through magnetic resonance imaging. Eleven consecutive IPD patients were compared to 9 healthy, age-matched controls. Results indicated that there is little or no difference between IPD patients and healthy controls in terms of OB volume. Based upon the relation between loss of olfactory input to the olfactory bulb and consecutive decrease in volume, these data support the idea that olfactory loss in IPD is not a primary consequence of damage to the olfactory epithelium but rather results from central-nervous changes.
authors.affiliation: Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Mueller
authors.forename: N D
authors.initials: ND
authors.lastname: Abolmaali
authors.forename: A R
authors.initials: AR
authors.lastname: Hakimi
authors.forename: T
authors.initials: T
authors.lastname: Gloeckler
authors.forename: B
authors.initials: B
authors.lastname: Herting
authors.forename: H
authors.initials: H
authors.lastname: Reichmann
authors.forename: T
authors.initials: T
authors.lastname: Hummel
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000209:etiology / Q000473:pathology*; D009830:Olfactory Bulb / Q000473:pathology*; D009831:Olfactory Mucosa / Q000473:pathology; D009833:Olfactory Pathways / Q000473:pathology; D010300:Parkinson Disease / Q000150:complications / Q000473:pathology*; D010865:Pilot Projects; D012903:Smell