title: Body mass index and blood glucose: correlations with serum insulin, growth hormone, and insulin-like growth factor-1 levels in patients with diffuse idiopathic skeletal hyperostosis (DISH).
abstract: Obesity is a frequent co-morbid condition associated with diffuse idiopathic skeletal hyperostosis (DISH). Serum growth hormone (GH), insulin-like growth factor (IGF-1) and insulin are significantly elevated in patients with DISH. In this study, we examined the relationship between body mass index (BMI) and basal serum GH, IGF-1, and insulin concentration in a group of 36 DISH patients. Basal serum insulin levels were significantly elevated (P<0.001) in DISH patients with a BMI>28 kg m(-2), classified as obese, compared with DISH patients with BMI ranging from 23 to 28 kg m(-2). In addition, BMI strongly positively correlated with serum insulin concentration in DISH patients (adjusted r2 = 0.348, P<0.001). However, BMI did not correlate with either basal serum GH (adjusted r2 = -0.013) or IGF-1 levels (adjusted r2 = -0.010) in DISH. We conclude that BMI does not seem to contribute to elevated serum GH and IGF-1 levels in symptomatic DISH.
authors.affiliation: Department of Medicine, Division of Rheumatic Diseases, University Hospitals of Cleveland, 2061 Cornell Road, Cleveland, OH 44106-5076, USA.
authors.forename: Charles W
authors.initials: CW
authors.lastname: Denko
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Malemud
mesh_terms: D000367:Age Factors; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D004057:Hyperostosis, Diffuse Idiopathic Skeletal / Q000097:blood* / Q000175:diagnosis; D007328:Insulin / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D009765:Obesity / Q000097:blood* / Q000175:diagnosis
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I