Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia.
BACKGROUND
The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia.


METHODS
We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.
Figueiredo
Maria Stella
MS
Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil. stella@hemato.epm.br
Vicari
Perla
P
Kimura
Eliza Yuriko Sugano
EY
Antunes
Sandra Vallin
SV
Yamamoto
Mihoko
M
D000208:Acute Disease; D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood / Q000150:complications*; D017809:Fatal Outcome; D006447:Hemoglobin H; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000209:etiology*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications; D013997:Time Factors
D006447:Hemoglobin H