[Comparative study of the effects of amphetamine and dimethoxymethamphetamine on brain self-stimulation in rats after perinatal administration of 6-hydroxydopamine].
The effects of amphetamine and its analog dimethoxymethamphetamine (DMA) on self-stimulation of the lateral hypothalamus was studied in adult rats treated with the neurotoxin 6-hydroxydopamine in the prenatal and early postnatal periods. Both compounds administered in a dose of 1 mg/kg produced similar activation of the brain self-stimulation suppressed by 6-hydroxydopamine. DMA, in contrast to amphetamine, did not produce such activation in intact rats and in the animals treated with 6-hydroxydopamine in the prenatal period.
Shabanov
P D
PD
Lebedev
A A
AA
D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine / Q000008:administration & dosage*; D000661:Amphetamine / Q000008:administration & dosage*; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D005260:Female; D006892:Hydroxydopamines / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012653:Self Stimulation / Q000187:drug effects*
D006892:Hydroxydopamines; D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine; D000661:Amphetamine