Abdominal obesity and expression of familial combined hyperlipidemia.
OBJECTIVE
To investigate the role of abdominal and body obesity on the prevalence of hyperlipidemia, in particular, hypertriglyceridemia, hypercholesterolemia, and high apolipoprotein B levels, in familial combined hyperlipidemia (FCHL) relatives and their spouses.


METHODS
In FCHL relatives (n = 618) and spouses (n = 297), prevalence data of hyperlipidemia and high apolipoprotein B levels and their age and gender-corrected odds ratios (ORs) were calculated for sex-adjusted categories of waist-to-hip ratio (WHR), waist circumference, and BMI.


RESULTS
Increments of BMI, waist circumference, and WHR increased the frequency of hyperlipidemia. In the whole study population (relatives and spouses combined), frequency of hypertriglyceridemia showed a significant interaction only between WHR categories and FCHL. This was studied further after stratification of relatives by multivariable logistic regression analyses corrected for age and gender. Predominant expression of hypertriglyceridemia was observed with higher categories of WHR in FCHL relatives (prevalence up to 57.6%, OR 8.48 in highest vs. lowest WHR category, p < 0.001) but not in spouses (up to 32.9%, OR 1.05 in highest vs. lowest WHR category, not significant).


CONCLUSIONS
Both in spouses and FCHL relatives, increments in BMI and waist circumference increased the prevalence of hyperlipidemia. Specifically, in FCHL relatives, WHR was the most informative determinant of the expression of hyperlipidemia, in particular, hypertriglyceridemia. The data indicate that FCHL develops against a background of abdominal obesity.
van der Kallen
Carla J H
CJ
Department of Medicine, University Hospital Maastricht, and Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands. c.vanderkallen@intmed.unimaas.nl
Voors-Pette
Christine
C
de Bruin
Tjerk W A
TW
D000005:Abdomen; D000328:Adult; D000375:Aging; D001055:Apolipoproteins B / Q000097:blood; D015992:Body Mass Index; D005260:Female; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000235:genetics* / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics* / Q000503:physiopathology; D016017:Odds Ratio; D012727:Sex Characteristics; D018454:Spouses; D049629:Waist-Hip Ratio
D001055:Apolipoproteins B