Anti-inflammatory strategies in hypertension: focus on COX-1 and COX-2.
An increasing body of evidence suggests that elevated levels of blood pressure may induce a proinflammatory response. Indeed, both C-reactive protein and blood pressure are independent determinants of cardiovascular risk, and, in combination, each parameter has additional predictive value. Hence, strategies targeted to lower blood pressure and reduce vascular inflammation may potentially provide clinical benefit. In this review, we discuss the role of chronic low-grade inflammation in the context of cardiovascular disease with a focus on roles of cyclooxygenase-1 and -2 in potential anti-inflammatory treatment strategies.
Hermann
Matthias
M
Cardiology, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, Switzerland.
Enseleit
Frank
F
Ruschitzka
Frank T
FT
D002318:Cardiovascular Diseases / Q000517:prevention & control; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007249:Inflammation / Q000188:drug therapy* / Q000503:physiopathology; D009569:Nitric Oxide / Q000502:physiology
D016861:Cyclooxygenase Inhibitors; D009569:Nitric Oxide