Silica coatings on clarithromycin.
Pre-crystallized clarithromycin (6-O-methylerythromycin A) particles were coated with silica from the tetraethyl orthosilicate (TEOS)-ethanol-aqueous ammonia system. The coatings had a typical thickness of 100-150 nm and presented about 15 wt.% of the silica-drug composite material. The properties of the coatings depended on reactant concentration, temperature and mixing rate and, in particular, on the presence of a cationic surfactant (cetylpyridinium chloride). In the presence of cetylpyridinium chloride the silica coatings slightly decreased the rate of pure clarithromycin dissolution.
Bele
Marjan
M
National Institute of Chemistry Slovenia, Hajdrihova 19, 1000 Ljubljana, Slovenia. marjan.bele@ki.si
Dmitrasinovic
Dorde
D
Planinsek
Odon
O
Salobir
Mateja
M
Srcic
Stane
S
Gaberscek
Miran
M
Jamnik
Janko
J
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics; D002594:Cetylpyridinium / Q000737:chemistry / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods; D017291:Clarithromycin / Q000737:chemistry / Q000493:pharmacokinetics*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003460:Crystallization; D008855:Microscopy, Electron, Scanning / Q000379:methods; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods
D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D012822:Silicon Dioxide; D002594:Cetylpyridinium; D017291:Clarithromycin