Simultaneous acquisition of multiple orders of intermolecular multiple-quantum coherence images in vivo.
Until recently, NMR imaging with intermolecular multiple-quantum coherences (iMQCs) has been based on the acquisition of a single echo. In vivo studies of iMQC image contrast would greatly benefit from a method that could acquire several orders of quantum coherence during the same acquisition. This would enable comparison of the image contrast for various orders and eliminate image coregistration problems between scans. It has previously been demonstrated that multiple orders of iMQC images can be simultaneously acquired of a simple phantom. Here, we examine the technique and its effect on biological tissue, both in vivo and in vitro. First, we establish the effectiveness of the iMQC sequence in vivo using earthworms as specimens. We then further show that the multi-CRAZED sequence enhances detection of next generation (nanoparticle) contrast agents on excised tumor tissue.
Shannon
Kerry L
KL
Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Branca
Rosa T
RT
Galiana
Gigi
G
Cenzano
Silvia
S
Bouchard
Louis-Serge
LS
Soboyejo
Winston
W
Warren
Warren S
WS
D000818:Animals; D003287:Contrast Media; D005260:Female; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000175:diagnosis; D051379:Mice; D008819:Mice, Nude; D008954:Models, Biological; D049329:Nanostructures; D009835:Oligochaeta; D019047:Phantoms, Imaging; D011789:Quantum Theory
D003287:Contrast Media