Does traumatic brain injury result in accelerated fracture healing?
In patients who have sustained a traumatic brain injury with an associated extremity fracture there is often a clinical perception that the rate of new bone formation around the fracture site is increased. Whether this rapidly forming new bone is fracture callus or a variant of heterotopic ossification, a common complication of traumatic brain injury, is the subject of some debate. This review will provide a comprehensive analysis on this topic and will discuss clinical and physiological evidence as well as potential areas for future research in this field.
Morley
John
J
Department of Trauma and Orthopaedic Surgery, St. James's University Hospital, University of Leeds, Beckett Street, Leeds LS9 7TF, UK.
Marsh
Sarah
S
Drakoulakis
Emmanuil
E
Pape
Hans-Christoph
HC
Giannoudis
Peter V
PV
D016723:Bone Remodeling / Q000502:physiology; D001930:Brain Injuries / Q000503:physiopathology*; D016207:Cytokines / Q000502:physiology; D017102:Fracture Healing / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology; D006728:Hormones / Q000502:physiology; D006801:Humans; D009999:Ossification, Heterotopic / Q000503:physiopathology; D010012:Osteogenesis / Q000502:physiology*; D012106:Research
D016207:Cytokines; D006133:Growth Substances; D006728:Hormones