title: Co-existence of pemphigus vulgaris and Hashimoto's thyroiditis.
abstract: We report a case of pemphigus vulgaris (PV) associated with Hashimoto's thyroiditis. Direct immunofluorescent studies revealed intercellular deposits of IgG and C3. Both anti-desmoglein (Dsg) 1 and Dsg 3 antibodies were positive in the patient's serum by enzyme-linked immunosorbent assays. HLA genotyping was performed from the patient's peripheral blood leukocytes by polymerase chain reaction. HLA-A*02011, -A*2402101, -DQA1*0104, -DQB1*05031 and -DRB1*1405 alleles, which confer strong susceptibility to Japanese patients with PV, were found. HLA-DQA1*0303 which is strongly associated with Hashimoto's thyroiditis in the Japanese population was also determined.
authors.affiliation: Department of Dermatology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku, Tokyo 173-0032, Japan. yuu-yoko@wg8.so-net.ne.jp
authors.forename: Yuko
authors.initials: Y
authors.lastname: Iino
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hara
authors.forename: Takane
authors.initials: T
authors.lastname: Suda
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Okada
authors.forename: Shunichi
authors.initials: S
authors.lastname: Baba
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D010392:Pemphigus / Q000150:complications*; D013967:Thyroiditis, Autoimmune / Q000150:complications*