title: Executive function and nonverbal memory in obsessive-compulsive disorder.
abstract: It has been suggested that memory impairments found in obsessive-compulsive disorder (OCD) are mediated by organizational problems in encoding that are caused by primary executive dysfunction. Performance on different nonverbal memory and executive skills was tested in 68 subjects (35 non-depressed OCD sufferers and 33 healthy controls). Multiple regression models were performed to analyze the role of different cognitive variables, especially organizational encoding strategies in nonverbal memory. OCD patients performed significantly worse than controls in immediate nonverbal memory [Rey-Osterrieth Complex Figure Test (RCFT)] and on all the executive functions such as interference control (Stroop test), mental set shifting (Trail-Making Test), and organizational strategies (copy organization). As no differences were found in the memory of faces, where organizational strategies are minimal, it is possible to speculate that immediate nonverbal memory problems in OCD appear only when organizational strategies mediate the recalling process. Thus, memory deficits appear to have less to do with memory, per se, and more to do with the degree of organization necessary to effectively complete the task. Statistical analyses of mediation models showed the highest explanatory power for the organizational approach and demonstrated the mediation effect of organizational strategies in nonverbal impairment.
authors.affiliation: Clinical Institute of Psychiatry and Psychology, Hospital Clínic, Barcelona, Spain. rpenades@clinic.ub.es
authors.forename: Rafael
authors.initials: R
authors.lastname: Penadés
authors.forename: Rosa
authors.initials: R
authors.lastname: Catalán
authors.forename: Susana
authors.initials: S
authors.lastname: Andrés
authors.forename: Manel
authors.initials: M
authors.lastname: Salamero
authors.forename: Cristóbal
authors.initials: C
authors.lastname: Gastó
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D003342:Corpus Striatum / Q000503:physiopathology; D003866:Depressive Disorder / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D008960:Models, Psychological; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index