title: [Effects of genistein on the proliferation and lipid peroxidation of rat aortic smooth muscle cells].
abstract: OBJECTIVE
  To investigate the effect of genistein on the proliferation and lipid peroxidation of rat aortic smooth muscle cells (SMC).
  
  
  METHODS
  Different concentrations of genistein were used to inhibit the proliferation of smooth muscle cells, and SOD, MDA, cAMP, 6-Keto-PGF1a in medium were observed. MTT method was used to assay the proliferation of SMC.
  
  
  RESULTS
  Compared with the control group, 0.1-100 micromol/L genistein could inhibit the proliferation of SMC by increasing SOD activity, raising cAMP and 6-Keto-PGF1a, reducing MDA (P<0.05, P<0.01), and the inhibitory action accompanied with the dose-effect relation.
authors.affiliation: Institute of Integrated Chinese Traditional and Western Medicine, Hebei Medical University, Shijiazhuang 050017.
authors.forename: Zaiwu
authors.initials: Z
authors.lastname: Cui
authors.forename: Xizhen
authors.initials: X
authors.lastname: Ge
authors.forename: En
authors.initials: E
authors.lastname: Li
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D019833:Genistein / Q000494:pharmacology*; D007529:Isoflavones / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max / Q000737:chemistry
chemical_list: D000975:Antioxidants; D007529:Isoflavones; D019833:Genistein