[Effect of high-oxygen water on enhancing anoxia endurance and anti-fatigue function and the possible mechanism].
OBJECTIVE
To investigate the effect of high-oxygen water on anoxia endurance and anti-fatigue function in mice and explore the possible mechanism.


METHODS
KM mice were used. Their body weight, serum urea nitrogen, hepatic glycogen, swimming-sustaining time of mice with a load, plasma lactic acid content, survival time under anoxia or sodium nitrite poisoning were measured.


RESULTS
It was found that high-oxygen water can prolong swimming time and can protract the anoxia survival time of mice under normal pressure and being afflicted with acute cerebral ischemia (P<0.05). It can also decrease the level of serum urea nitrogen after exercise (P<0.05) and increase hepatic glycogen storage (P<0.05).


CONCLUSIONS
The results demonstrate that high-oxygen water can enhance the emergent survival ability of mice, the ability of fatigue recovery and anoxia endurance function. It also can increase the energy storage.
Liu
Heng-chuan
HC
Department of Medical Technology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
Zhang
Hong
H
Li
Zao-ping
ZP
Wang
Bo
B
D000818:Animals; D005221:Fatigue / Q000517:prevention & control*; D000860:Hypoxia / Q000503:physiopathology*; D002534:Hypoxia, Brain / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism; D010100:Oxygen / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000187:drug effects*; D014867:Water / Q000008:administration & dosage / Q000737:chemistry
D014867:Water; D019344:Lactic Acid; D010100:Oxygen