title: Nitric oxide and blood: a review.
abstract: Nitric oxide (NO) was identified as a physiological mediator of vascular tone in 1987. NO produced by endothelial cells causes vasodilatation and also inhibits platelet aggregation and leucocyte adhesion. Red cells metabolize NO to nitrate but may possibly carry and release, or even produce, NO in hypoxic conditions. NO physiology may have important implications for transfusion medicine, ranging from adverse effects of haemoglobin substitutes to preservation of stored platelets and to detrimental effects of stored red cells.
authors.affiliation: Department of Haematology, Freeman Hospital, High Heaton, Newcastle Upon Tyne, UK. jonathan.wallis@tfh.nuth.northy.nhs.uk
authors.forename: J P
authors.initials: JP
authors.lastname: Wallis
mesh_terms: D001773:Blood Cells / Q000502:physiology*; D001803:Blood Transfusion; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D015539:Platelet Activation / Q000502:physiology; D010974:Platelet Aggregation / Q000502:physiology; D014664:Vasodilation / Q000502:physiology*
chemical_list: D009569:Nitric Oxide