Lithium-induced alterations in nucleoside triphosphate levels in human brain: a proton-decoupled 31P magnetic resonance spectroscopy study.
We examined how lithium's demonstrated effects on various cellular processes in human brain would be reflected in the (31)P magnetic resonance spectra of living human beings with respect to brain high-energy phosphate metabolites. Eight healthy volunteers received a baseline (31)P magnetic resonance spectroscopy (MRS) scan, after which they received lithium carbonate, 900 mg/day, for 14 days. Follow-up MRS scans were obtained on day 7 and on day 14. We detected a lithium-induced decrease in alpha-, beta-, gamma- and total nucleoside triphosphate NTP levels with chronic administration of lithium. On day 7, significant decreases were noted in gamma-NTP (14%) and total NTP (11%) levels. There was a trend for a decrease in beta-NTP (11%) levels. On day 14, significant decreases were noted in alpha-NTP (7%) and total NTP (8%) levels. There was a trend for a decrease in beta-NTP (16%) levels. Lithium caused a 25% reduction in inorganic phosphate (P(i)) levels on day 14. The theoretical relevance of the lithium-induced alterations on brain high-energy phosphates to the lithium-induced modifications of neuroplasticity is discussed.
Yildiz
Aysegul
A
Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey. agul_yildiz@hotmail.com
Moore
Constance M
CM
Sachs
Gary S
GS
Demopulos
Christina M
CM
Tunca
Zeliha
Z
Erbayraktar
Zubeyde
Z
Renshaw
Perry F
PF
D000293:Adolescent; D000328:Adult; D018692:Antimanic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity; D043583:Nucleoside-Triphosphatase / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D011522:Protons
D018692:Antimanic Agents; D010710:Phosphates; D011522:Protons; D016651:Lithium Carbonate; D043583:Nucleoside-Triphosphatase