title: Severe autoimmune hemolytic anemia treated by paralysis, induced hypothermia, and splenic embolization.
abstract: Autoimmune hemolytic anemia (AIHA) is the clinical condition in which IgG antibodies bind to RBC surface antigens and initiate RBC destruction via the complement and reticuloendothelial system. AIHA is commonly treated with transfusions, corticosteroids, and splenectomy. We present a case of an adult with life-threatening AIHA secondary to ulcerative colitis emergently managed with neuromuscular paralysis, induced hypothermia, and splenic embolization.
authors.affiliation: Department of Critical Care, University of Pittsburgh, 640A Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA. maripe@ccm.upmc.edu
authors.forename: Ronna
authors.initials: R
authors.lastname: Campbell
authors.forename: Paul E
authors.initials: PE
authors.lastname: Marik
mesh_terms: D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000000981:diagnostic imaging / Q000628:therapy*; D015209:Cholangitis, Sclerosing / Q000601:surgery; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000150:complications*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007036:Hypothermia, Induced; D007362:Intensive Care Units; D019148:Neuromuscular Blockade; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000628:therapy; D015742:Propofol / Q000008:administration & dosage; D013154:Spleen / Q000098:blood supply*; D014057:Tomography, X-Ray Computed; D014673:Vecuronium Bromide / Q000008:administration & dosage
chemical_list: D014673:Vecuronium Bromide; D015742:Propofol