[Effects of L-tetrahydropalmatine on concentrations of neurotransmitter amino acids in mice with cerebral ischemia].
OBJECTIVE
To observe the effects of L-tetrahydropalmatine (L-THP) on concentrations of neurotransmitter amino acids in mice with cerebral ischemia and to discuss the mechanisms of L-THP in tyreating cerebral ischemia.


METHODS
Mice were randomly divided into six groups: control group, cerebral ischemia group, L-THP treated group (doses were 14, 28, 56 mg x kg(-1) respectively) and Ginkgo biloba extract treated group. Concentrations of Glu and GABA were determined by HPLC.


RESULTS
Compared with control group, Glu and GABA in mice with cerebral ischemia were much higher. The ratio of Glu/GABA increased significantly. L-THP markedly reduced the concentrations of Glu and the ratio of Glu/GABA in mice with cerebral ischemia.


CONCLUSIONS
Decrease in Glu concertration and ratio of Glu/GABA may be one of the mechanisms of L-THP in treating cerebral ischemia.
Zhang
Zhong-miao
ZM
Department of Clinical Pharmacy, The Second Affiliated Hospital, College of Medicinal Sciences, Zhejiang University, Hangzhou 310009, China.
Zheng
Xiao-xiang
XX
Jiang
Bo
B
Zhou
Quan
Q
D000818:Animals; D001600:Berberine Alkaloids / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018696:Neuroprotective Agents / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D013237:Stereoisomerism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D018698:Glutamic Acid; C014215:tetrahydropalmatine; D005680:gamma-Aminobutyric Acid