Comparison of the strain Doppler echocardiographic features of familial amyloid polyneuropathy (FAP) and light-chain amyloidosis.
Previous work has demonstrated that familial amyloid polyneuropathy (FAP) and light-chain amyloidosis with similar degrees of cardiac involvement cannot be distinguished by standard echocardiographic parameters, yet the severity of congestive heart failure and cardiac mortality is much less in FAP. It was therefore hypothesized that strain and strain-rate imaging, sensitive markers of longitudinal systolic dysfunction, might detect a difference in left ventricular function between FAP and light-chain amyloidosis that could account for the clinical differences.
Ogiwara
Fumiaki
F
Division of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Koyama
Jun
J
Ikeda
Shu-Ichi
S
Kinoshita
Osamu
O
Falk
Rodney H
RH
D028227:Amyloid Neuropathies, Familial / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology
D007147:Immunoglobulin Light Chains