ApoC-III bound to apoB-containing lipoproteins increase with insulin resistance in Cherokee Indian youth.
Because Native Americans are predisposed to obesity and type 2 diabetes associated with coronary artery disease, we assessed whether apoC-III bound to apoB-containing (LpB:C-III) and apoA-containing (LpA:C-III) lipoproteins, total apoC-III, apoB, and plasma lipids are associated with insulin resistance, body mass index (BMI), and waist circumference in Cherokee children and adolescents aged 5 to 19 years (n = 975). A cross-sectional analysis was done to determine associations of the lipoproteins with the homeostasis index (HOMA-IR) and BMI. When the data were grouped by quartiles for HOMA-IR and separated by three 5-year age groups (5-9, 10-14, and 15-19 years), the trend for LpB:C-III, triglyceride, and BMI z score to increase was significant for all age groups and both genders (P < .001). The trend to increase LpB:C-III with age was greater in boys (P < .0001) than in girls (P < .05) who tended to plateau after the age of 10 years. In contrast, the ratio of LpA:C-III to LpB:C-III decreased and the decrease was greater in boys (P < .0001) than girls (P < .01). Body mass index z score and waist circumference were correlated with LpB:C-III, triglyceride, apoB, and non-high-density lipoprotein cholesterol within each gender (P < .001). In multiple regression models, LpB:C-III, the dependent variable, was associated with HOMA-IR for both genders. We conclude that increases in LpB:C-III in childhood and adolescence are associated with insulin resistance and obesity supporting the need for prevention programs.
Blackett
Piers R
PR
Department of Pediatrics, Children's Hospital Oklahoma, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. piers-blackett@ouhsc.edu
Blevins
Kathleen S
KS
Quintana
Elaine
E
Stoddart
Martha
M
Wang
Wenyu
W
Alaupovic
Petar
P
Lee
Elisa T
ET
D000293:Adolescent; D000328:Adult; D053305:Apolipoprotein C-III; D001055:Apolipoproteins B / Q000378:metabolism*; D001056:Apolipoproteins C / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002648:Child; D005260:Female; D006801:Humans; D007198:Indians, North American; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D012727:Sex Characteristics; D049629:Waist-Hip Ratio
D053305:Apolipoprotein C-III; D001055:Apolipoproteins B; D001056:Apolipoproteins C; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D008074:Lipoproteins