title: A general method for making bicyclic compounds with nitrogen at a bridgehead--application to the halichlorine spiro subunit.
abstract: N-protected beta-amino aldehydes having the nitrogen in a ring are easily converted into Morita-Baylis-Hillman adducts; O-acetylation and N-deprotection result in spontaneous cyclization to bicyclic structures having nitrogen at a bridgehead.
authors.affiliation: Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. derrick.clive@ualberta.ca.
authors.forename: Derrick L J
authors.initials: DL
authors.lastname: Clive
authors.forename: Maolin
authors.initials: M
authors.lastname: Yu
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Li
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D008968:Molecular Conformation; D009584:Nitrogen / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D001643:Bridged Bicyclo Compounds; D013141:Spiro Compounds; C412666:halichlorine; D009584:Nitrogen