Simultaneous confidence bounds for low-dose risk assessment with nonquantal data.
We study the use of simultaneous confidence bounds for making low-dose inferences in quantitative risk analysis. Confidence limits are constructed for outcomes measured on a continuous scale, assuming a simple linear model for the observed response. From the simultaneous confidence bounds, simultaneous lower limits on the benchmark dose associated with a particular risk are also constructed.
Piegorsch
Walter W
WW
Department of Statistics, University of South Carolina, Columbia, South Carolina, USA. piegorsc@stat.sc.edu
West
R Webster
RW
Pan
Wei
W
Kodell
Ralph L
RL
D000818:Animals; D016001:Confidence Intervals; D004305:Dose-Response Relationship, Drug; D016014:Linear Models; D008297:Male; D009010:Monte Carlo Method; D051381:Rats; D011916:Rats, Inbred F344; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data