title: Fenofibric acid.
abstract: Unlike the related fenofibrate molecule [Henry, Zhang, Gao & Bruckner (2003). Acta Cryst. E59, o699-o700], fenofibric acid {systematic name: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid}, C17H15ClO4, contains a carboxylic acid moiety instead of an ester moiety. This polar moiety plays an important role in the formation of a rare acid-to-ketone hydrogen-bond-type packing interaction. The lack of an isopropyl group in fenofibric acid aligns the carboxyl group on the same side as the ketone carbonyl group; this conformation may play an important role in discrimination between the acid and the fenofibrate molecule in molecular recognition.
authors.affiliation: Department of Chemistry and Biochemistry, University of Missouri-St Louis, MO 63121, USA.
authors.forename: Nigam P
authors.initials: NP
authors.lastname: Rath
authors.forename: Wahajul
authors.initials: W
authors.lastname: Haq
authors.forename: Ganesaratnam K
authors.initials: GK
authors.lastname: Balendiran
mesh_terms: D000924:Anticholesteremic Agents / Q000737:chemistry; D018360:Crystallography, X-Ray; D011345:Fenofibrate / Q000031:analogs & derivatives* / Q000737:chemistry; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D000924:Anticholesteremic Agents; C006012:fenofibric acid; D011345:Fenofibrate