title: [Effects of Astragalus and saponins of Panax notoginseng on MMP-9 in patients with type 2 diabetic macroangiopathy].
abstract: OBJECTIVE
  To investigate the role and mechanism of Astragalus (AS) and saponins of Panax notoginseng (PNS) in treating type 2 diabetic macroangiopathy.
  
  
  METHODS
  94 patients with type 2 diabetic macroangiopathy were divided into two groups randomly: group treated with Simvastatin and group treated with AS and PNS, compared with 40 healthy control subjects. Serum level of MMP-9 and lipid in patients and healthy subjects were measured before and after treatment.
  
  
  RESULTS
  The serum levels of MMP-9, TG, TC, LDL-C, VLDL-C in patients with type 2 diabetic macroangiopathy were improved, while the levels of HDL-C were decreased. Like Simvastatin AS and PNS had the function of reducing MMP-9 and accommodating lipid metabolism.
  
  
  CONCLUSIONS
  Besides accommodating lipid metabolism, AS and PNS can also reduce the level of serum MMP-9 soas to treat type 2 diabetic macroangiopathy.
authors.affiliation: Department of Endocrinology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
authors.forename: Kuan-zhi
authors.initials: KZ
authors.lastname: Liu
authors.forename: Jing-bo
authors.initials: JB
authors.lastname: Li
authors.forename: Hai-li
authors.initials: HL
authors.lastname: Lu
authors.forename: Jin-kun
authors.initials: JK
authors.lastname: Wen
authors.forename: Mei
authors.initials: M
authors.lastname: Han
mesh_terms: D000368:Aged; D027885:Astragalus propinquus / Q000737:chemistry; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D036145:Ginsenosides / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D005894:Panax / Q000737:chemistry; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D019821:Simvastatin / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D000960:Hypolipidemic Agents; D008055:Lipids; D019821:Simvastatin; D020780:Matrix Metalloproteinase 9