Cerebral concentrations of myo-inositol in rats with induced brain death.
In anaesthetized, mechanically ventilated rats with brain death induced by epidural balloon inflation, we assessed the levels of cerebral myo-inositol in three brain areas 4 h after brain death had been confirmed. The levels were measured using HPLC, along with the water content. Myo-inositol levels were significantly increased in the cerebellum (P<0.05) and decreased in the brainstem (P<0.001), compared to findings in controls. Such changes can serve as hallmarks of brain death.
Kiyoshima
Akiko
A
Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashu-ku, Fukuoka 812-8582, Japan.
Kudo
Keiko
K
Goto
Yoshinobu
Y
Tobimatsu
Shozo
S
Ikeda
Noriaki
N
D000818:Animals; D001923:Brain Chemistry; D001926:Brain Death / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D049429:Forensic Pathology; D007294:Inositol / Q000032:analysis*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D007294:Inositol