[Effect of antibiotics on Na(+),K(+)-ATP-ase activity of the membranes in the Misgurnus fossilis L. embryos].
The influence of some antibiotics of the fluoroquinolone classes on the Na+, K(+)-ATP-ase activity of loach embryo (Misqurnus fossilis L.) was investigated at different stages of blastomer divisions. It was determined that norofloxacin and borocin induce a dose-dependent decrease in Na+, K(+)-ATP-ase activity. Addition of norofloxacin (5.25 mcg/ml) into the incubation media caused pronounced oscillations in Na+, K(+)-ATP-ase activity, following borocin addition (5,15.25 mcg/ml) this effect was less pronounced. A conclusion was drawn about the influence of the fluoroquinolone on the membrane level.
Tselevych
M V
MV
Mandzynets'
S M
SM
Sanahurs'kyĭ
D I
DI
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001757:Blastomeres / Q000187:drug effects / Q000201:enzymology; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects* / Q000201:enzymology; D003531:Cypriniformes / Q000196:embryology*; D004305:Dose-Response Relationship, Drug; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000187:drug effects; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000254:Sodium-Potassium-Exchanging ATPase