Nutritional interactions in intestinal cadmium uptake--possibilities for risk reduction.
Effects of dietary composition and trace element status on fractional intestinal cadmium uptake is reviewed below. Fractional cadmium uptake is of fundamental importance for internal dose, related individual susceptibility to cadmium, induced renal damage and eventually bone disease. Diet composition with regard to macronutrients has some effects on cadmium bioavailability. Major determinants of intestinal cadmium uptake are however diet composition with regard to crude fibres and trace elements, especially iron. Deficiencies may increase intestinal cadmium uptake 5-8 times. Ultimate risk management would be not to raise crops on cadmium polluted soil. Provisionally, assurance of optimal trace element statusin persons exposed to cadmium is essential for risk reduction.
Andersen
Ole
O
Department of Life Sciences and Chemistry, Roskilde University, Roskilde, Denmark. andersen@ruc.dk
Nielsen
Jesper B
JB
Nordberg
Gunnar F
GF
D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D003677:Deficiency Diseases / Q000378:metabolism; D004032:Diet; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*
D002104:Cadmium