title: Prognostic factors for survival in patients with early-intermediate hepatocellular carcinoma undergoing non-surgical therapy: comparison of Okuda, CLIP, and BCLC staging systems in a single Italian centre.
abstract: BACKGROUND
  Several prognostic models have been developed to stage hepatocellular carcinoma (HCC) but there is no general consensus on which is the most reliable. We compared three prognostic indices (Okuda, CLIP, and BCLC scoring systems) in a large series of cirrhotic patients with HCC undergoing non-surgical treatment in terms of their ability to classify patients into different risk groups
  
  
  METHODS
  We retrospectively studied 268 Italian patients with HCC. A total of 146 patients were treated with ablation, 132 with percutaneous ethanol injection, and 14 with radiofrequency ablation; 103 underwent transcatheter arterial chemoembolisation and 19 had supportive care alone. Factors determining survival were analysed by univariate and multivariate analysis using the Kaplan-Meier method and Cox proportional hazard regression models. Okuda, CLIP, and BCLC scores evaluated before treatment were applied.
  
  
  RESULTS
  Median survival was 25.7 months. In a multivariate analysis, portal vein thrombosis, alpha fetoprotein, total bilirubin, and tumour size were significant predictors of survival. Okuda, CLIP, and BCLC scores were all able to predict survival (p<0.001). They identified two, four, and six risk groups, respectively, with a median survival ranging from 27 to 19 months for Okuda, 30 to 5 months for CLIP, and 43 to 7 months for BCLC.
  
  
  CONCLUSIONS
  Both CLIP and BCLC scores were more effective than the Okuda score in stratifying patients into different risk groups with early-intermediate HCC. However, the BCLC scoring system gave a better prediction of prognosis in patients with disease diagnosis at a very early stage.
authors.affiliation: Department of Internal Medicine, Policlinico Universitario A Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy. agrieco@rm.unicatt.it
authors.forename: A
authors.initials: A
authors.lastname: Grieco
authors.forename: M
authors.initials: M
authors.lastname: Pompili
authors.forename: G
authors.initials: G
authors.lastname: Caminiti
authors.forename: L
authors.initials: L
authors.lastname: Miele
authors.forename: M
authors.initials: M
authors.lastname: Covino
authors.forename: B
authors.initials: B
authors.lastname: Alfei
authors.forename: G L
authors.initials: GL
authors.lastname: Rapaccini
authors.forename: G
authors.initials: G
authors.lastname: Gasbarrini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001663:Bilirubin / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D011169:Portal Vein; D011379:Prognosis; D012720:Severity of Illness Index; D020246:Venous Thrombosis / Q000150:complications; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins; D001663:Bilirubin