title: Forward and backward recurrence times and length biased sampling: age specific models.
abstract: Consider a chronic disease process which is beginning to be observed at a point in chronological time. The backward recurrence and forward recurrence times are defined for prevalent cases as the time with disease and the time to leave the disease state, respectively, where the reference point is the point in time at which the disease process is being observed. In this setting the incidence of disease affects the recurrence time distributions. In addition, the survival of prevalent cases will tend to be greater than the population with disease due to length biased sampling. A similar problem arises in models for the early detection of disease. In this case the backward recurrence time is how long an individual has had disease before detection and the forward recurrence time is the time gained by early diagnosis, i.e., until the disease becomes clinical by exhibiting signs or symptoms. In these examples the incidence of disease may be age related resulting in a non-stationary process. The resulting recurrence time distributions are derived as well as some generalization of length-biased sampling.
authors.affiliation: Harvard School of Public Health and the Dana-Farber Cancer Institute, Boston, MA 02115, USA. zelen@jimmy.harvard.edu
authors.forename: Marvin
authors.initials: M
authors.lastname: Zelen
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D015982:Bias; D002908:Chronic Disease / Q000401:mortality* / Q000628:therapy; D042241:Early Diagnosis; D006801:Humans; D008954:Models, Biological; D012008:Recurrence; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D016019:Survival Analysis