[Blood plasma resistance to activated protein C as a risk factor of disseminated intravascular coagulation in acute-poisoned patients].
The aim of this work was to assess the prevalence of the blood plasma resistance to activated protein C as a risk factor of disseminated intravascular coagulation (DIC) in acute-poisoned patients. The number of examined people was 231, including 140 acute-poisoned patients (of whom 83 showed DIC's finding) and 91 clinically healthy controls. The resistance of examined plasma to the anticoagulating properties of activated protein C was assessed by Chromogenix APC-Resistance V assay (APC-R-V). Abnormal results of APC-R-V were found to be 6-fold more frequent in acute-poisoned patients with DIC syndrome: 20 of 83 (24.1%), vs 3 of 91 (3.3%) for the control. The differences were statistically significant at p=0.0001 Mean values of coefficient R were statistically significantly lower in the acute-poisoned patients with DIC syndrome than the control, p<0.001. Genetic tests preformed in 37 patients confirmed V Leiden mutation to be present people whose R index value was below 2.0. Detection of APC-R in acute-poisoned patients could facilitate implementation of suitable preventive procedure before the DIC symptoms become manifest.
Barańska
Małgorzata
M
Zakład Immunotoksykologii, Instytutu Medycyny Pracy, J. Nofera, Lódź. mbaran@imp.lodz.pl
Kur
Barbara
B
Prazanowski
Mirosław
M
Lutz
Waldemar
W
D000208:Acute Disease; D000328:Adult; D016022:Case-Control Studies; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000209:etiology; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000378:metabolism*; D011041:Poisoning / Q000097:blood / Q000150:complications; D015995:Prevalence; D011486:Protein C / Q000378:metabolism*; D012307:Risk Factors
D011486:Protein C; D005165:Factor V