[Study of antithrombotic function of endothelium in vascular tissue engineering].
OBJECTIVE
To investigate the current situation and developing trend of antithrombotic function study of endothelium in vascular tissue engineering.


METHODS
The effect of several elements on the antithrombotic ability of endothelium, including the source of endothelium, the characteristic of the matrix materials, the cell culture methods, and the endothelium's gene modification were analyzed.


RESULTS
The normal antithrombotic function of tissue engineered vascular relied on the source of endothelium, gene modification of seeding cells, the cell culture methods in vitro, and the characteristic of the scaffolds.


CONCLUSIONS
The establishment of an ideal antithrombotic functional tissue engineering vascular still requires further studies in various aspects including seeding cells, matrix materials, and cell culture methods. Gene modification of vascular endothelium, which improves the antithrombotic ability, deserves more attention.
Zheng
Lei
L
Department of Clinical Laboratory, Southern Medical University (the First Military Medical University), Guangzhou Guangdong 510515, P R China.
Wang
Qian
Q
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D001807:Blood Vessel Prosthesis; D018929:Cell Culture Techniques; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D013927:Thrombosis / Q000517:prevention & control; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials