Epoxidation with an electrocatalytic p-450 model system in an acidic solution.
An electrochemical P-450 model system using meso-tetraphenylporphyrinatomanganese(III) chloride (MnTPP), imidazole and acetic acid was tested in an acetonitrile solution, and epoxide was obtained with a good current efficiency. The results of cyclic voltammetry revealed that acid plays an important role in the second electron transfer.
Michida
Takashi
T
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Kobe, Japan. michida@pharm.kobegakuin.ac.jp
Saiki
Chika
C
Yamasaki
Chie
C
Yamaoka
Yumiko
Y
D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004563:Electrochemistry; D004852:Epoxy Compounds / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D011166:Porphyrins; D012996:Solutions
D004852:Epoxy Compounds; D007202:Indicators and Reagents; D011166:Porphyrins; D012996:Solutions; C016136:tetraphenylporphine sulfonate; D003577:Cytochrome P-450 Enzyme System