[The preparation of PELGE-NP and a study of the factors affecting their diameter].
OBJECTIVE
To prepare Poly(ethylene glycol)-poly(lacticacid-co-glycolicacid)-poly(ethylene-glycol) nanoparticles (PELGE-NP) and investigate the factors affecting their diameter.


METHODS
PELGE were synthesized by ring-opening polymerization, PELGE nanoparticles (PELGE-NP) were prepared by using the emulsion-solvent evaporation technique (O/W). Orthogonal design was applied to optimize the preparation technology on the basis of the single factor evaluation.


RESULTS
The optimal conditions for preparing nanoparticles included the PELGE at concentration of 10 mg/ml, the ratio of acetone/DCM at 2/3, the F68 at concentration of 3%, and the volume ratio of O/W at 1/8 (V/V).


CONCLUSIONS
The prepared PELGE nanoparticles are spherical and discrete particles without aggregation; they are smooth in surface morphology, and their diameters range from 60 nm to 100 nm.
Duan
You-rong
YR
West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Zhang
Zhi-rong
ZR
Tang
Yong-gang
YG
D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D007773:Lactates / Q000138:chemical synthesis; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis; D011098:Polyglactin 910 / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry
D004337:Drug Carriers; D007773:Lactates; D011091:Polyesters; D012997:Solvents; C088513:poly(lactic acid-ethylene glycol); D011098:Polyglactin 910; D011092:Polyethylene Glycols