[Association of the novel hydatidiform mole-related gene F10 with the invasiveness of trophoblastic tumor].
OBJECTIVE
To study the expressions of the novel gene F10 associated with hydatidiform mole in different trophoblastic tumors and explore the relation of F10 expression with the invasiveness of malignant trophoblastic tumor.


METHODS
In situ hybridization was used to study the expression of F10 in 12 cases of hydatidiform mole, 6 cases of invasive mole, and 8 cases of choriocarcinoma.


RESULTS
F10 mRNA was positive in all cases of hydatidiform mole, invasive mole, and choriocarcinoma, and the expression intensity significantly increased in the order of hydatidiform mole, invasive mole and choriocarcinoma (P<0.001).


CONCLUSIONS
The expression of F10 gene may relate to the occurrence and invasiveness of trophoblastic tumor, with possible involvement in the invasion or malignant changes of trophoblastic cells.
Zhou
Jin
J
Department of Obstetriscs and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Chen
Shi-Ling
SL
Xing
Fu-Qi
FQ
Pang
Zhan-Jun
ZJ
Li
Bing
B
Zhou
Wen-Qu
WQ
Fu
Xin
X
Ding
Yan-Qing
YQ
D000328:Adult; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D052138:Genes, Neoplasm / Q000235:genetics*; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics*; D002820:Hydatidiform Mole, Invasive / Q000235:genetics*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000235:genetics* / Q000473:pathology; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology