Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives.
We examined the human immunodeficiency virus-reverse transcriptase and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of cationic, anionic, and amino acid-type fullerene derivatives. Among the fullerene derivatives, the amino acid-type fullerene derivative was the most efficient in human immunodeficiency virus-reverse transcriptase inhibition.
Mashino
Tadahiko
T
Kyoritsu University of Pharmacy, Shibakoen 1-5-30, Minato-ku, Tokyo 105-8512, Japan. mashino-td@kyoritsu-ph.ac.jp
Shimotohno
Kumiko
K
Ikegami
Noriko
N
Nishikawa
Dai
D
Okuda
Kensuke
K
Takahashi
Kyoko
K
Nakamura
Shigeo
S
Mochizuki
Masataka
M
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology; D054303:HIV Reverse Transcriptase / Q000187:drug effects; D016174:Hepacivirus / Q000201:enzymology*; D006801:Humans; D020128:Inhibitory Concentration 50; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors*; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D037741:Fullerenes; D018894:Reverse Transcriptase Inhibitors; D012324:RNA-Dependent RNA Polymerase; D054303:HIV Reverse Transcriptase