title: Association of PLA2 polymorphism of the ITGB3 gene with early fetal loss.
abstract: To study the association between early fetal loss and the presence of the PLA2 polymorphism of the ITGB3 gene we conducted a case-control study on 98 cases (i.e., women in fertile age, who experienced at least one episode of early fetal loss) and 38 healthy controls. PLA2 polymorphism was present in 44.2% of cases and 18.4% of controls, and cases with one (n = 24) event had an odds ratio (OR) = 2.7 (95% confidence interval [CI] 0.7-10.0), with two events (n = 52) an OR = 3.8 (95% CI 1.3-11.5), and with three (n = 16) or four abortions (n = 6) had a combined OR = 4.4 (95% CI 1.2-17.0), compared to controls, indicating that PLA2 polymorphism may be implicated in an inherited form of thrombophilia, and to early fetal loss.
authors.affiliation: Clinical Pathology Laboratory, Istituto Dermopatico dell'Immacolata (IDI-IRCCS), Rome, Italy. l.ruzzi@idi.it
authors.forename: Laura
authors.initials: L
authors.lastname: Ruzzi
authors.forename: Iolanda
authors.initials: I
authors.lastname: Ciarafoni
authors.forename: Lorena
authors.initials: L
authors.lastname: Silvestri
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Semeraro
authors.forename: Damiano
authors.initials: D
authors.lastname: Abeni
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics*; D016824:Antigens, Human Platelet / Q000235:genetics*; D005260:Female; D005313:Fetal Death / Q000235:genetics; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011379:Prognosis
chemical_list: D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; C083451:human platelet antigen 1b