Recommendation to include methyldibromo glutaronitrile in the European standard patch test series.
The preservative methyldibromo glutaronitrilc (MDBGN) is used non-occupationally and occupationally. High contact allergy rates have been reported when tested in consecutive dermatitis patients as well as clinical cases with allergic contact dermatitis. Up till now there has been no agreement on which patch test preparation to use to trace contact allergy to MDBGN. From the year 2005 on, MDBGN at 0.5% w/w in petrolatum is recommended for the European standard patch test series. The choice of 0.5% is based on consideration of rates of contact allergy, doubtful and irritant reactions, as well as on information on clinical relevance represented by results of a repeated open application test, and patch test concentrations to diagnose allergic contact dermatitis from MDBGN in individual cases.
Bruze
Magnus
M
Department of Occupational and Environmental Dermatology, University Hospital, S-20502 Malmö, Sweden. magnus.bruze@derm.mas.lu.se
Goossens
An
A
Gruvberger
Birgitta
B
D000485:Allergens / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D005060:Europe; D006287:Health Planning Guidelines; D006801:Humans; D008452:Maximum Allowable Concentration; D009570:Nitriles / Q000009:adverse effects*; D010328:Patch Tests / Q000379:methods / Q000592:standards*; D017410:Practice Guidelines as Topic; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D012107:Research Design; D013997:Time Factors
D000485:Allergens; D009570:Nitriles; D011310:Preservatives, Pharmaceutical; C039411:1,2-dibromo-2,4-dicyanobutane