Enhanced expression of protein phosphatase 2A associated with hyper-phosphorylation of histone H1 in Alzheimer's disease brain.
In this study, we analyzed high expression of protein phosphatase (PP) 2A in Alzheimer's disease brain compared to that of the control brain, which result from hyperphosphorylation of histone H1. PP1alpha and PP1gamma1 were slightly expressed in all cases, but there was no relation to the levels of the phosphate in histone H1.
Mori
Satoshi
S
Department of Orthopaedic Surgery, Kagawa Medical College, Mikicho 1750-1, Kagawa 761-0701, Japan.
Cao
Yongping
Y
Sogawa
Kenichi
K
Kondo
Kazuya
K
Sakai
Tohru
T
Hino
Norifumi
N
Yamashiro
Hisakazu
H
Okada
Masanao
M
Miyamoto
Kazuo
K
Kawaguchi
Yoji
Y
Mashiba
Tasuku
T
Norimatsu
Hiromichi
H
D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism*; D016022:Case-Control Studies; D006657:Histones / Q000378:metabolism*; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D010766:Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism*; D054648:Protein Phosphatase 2
D006657:Histones; D010770:Phosphotransferases; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2