Is IS(ABA-1) customized for Acinetobacter?
An insertion sequence (IS(ABA-1)) was identified in Acinetobacter spp., but not in Enterobacteriacea and Pseudomonas aeruginosa. Numerous copies of the IS were identified in Acinetobacter strains containing the element. In one of the Acinetobacter baumannii strains, IS(ABA-1) was identified adjacent to sulII and transcription of the resistance gene is presumed to be dependent on promoter sequences within the IS. Since the IS is adjacent to ampC and bla(OXA) in this A. baumannii strain, it may be that IS(ABA-1) plays an important role in the expression of antibiotic resistance genes in this genus.
Segal
Heidi
H
Division of Medical Microbiology, Medical School UCT, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road Observatory 7925, Cape Town, South Africa.
Garny
Seike
S
Elisha
B Gay
BG
D000150:Acinetobacter / Q000145:classification / Q000187:drug effects* / Q000235:genetics*; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D003001:Cloning, Molecular; D004251:DNA Transposable Elements / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D011550:Pseudomonas aeruginosa / Q000235:genetics; D017422:Sequence Analysis, DNA; D013449:Sulfonamides / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements; D013449:Sulfonamides