HLA-DR,DQ and APOE genotypes and gender influence in Sardinian primary progressive MS.
The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. The risk of the primary progressive course was increased (odds ratio = 6.81, p = 0.002) in women carrying the APOE4 but not the DRB1-DQB1 predisposing genotype, suggesting in this subgroup of patients a reciprocal influence between these genes and gender in modulating clinical variability of the disease.
Cocco
E
E
Centro Sclerosi Multipla, Dipartimento di Neuroscienze, Università di Cagliari, Italy.
Sotgiu
A
A
Costa
G
G
Murru
M R
MR
Mancosu
C
C
Murru
R
R
Lai
M
M
Contu
P
P
Marrosu
M G
MG
D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D020528:Multiple Sclerosis, Chronic Progressive; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic; D012306:Risk; D012737:Sex Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens