[TNF alfa modulators in the treatment of rheumatoid arthritis].
Current slow-acting anti-rheumatic drugs available at now for rheumatoid arthritis fail in majority of cases and have an inconstant chondro-protective effect. Improvements in our knowledge of its pathogenesis and advances in molecular biology have made possible to develop selective immunotherapy approaches. Tumor necrosis factor alfa (TNF alfa) is an important inflammatory mediator that play a crucial role in rheumatoid arthritis. This studies summarizes clinical essays that evaluate beneficial effects and tolerance of anti TNF alfa antibodies. This study showed the clinical, biological and radiological efficacy of these therapeutic agents. But some doubts persist concerning their long term side effects particularly infections, neoplasm or auto immune ones. High price of this treatment should evaluate report cost benefice to appreciate the better utilisation of these drugs.
Kochbati
Samir
S
Service de médecine interne, Hôpital Habib Thameur, Tunis, Tunisie.
Boussema
Fatma
F
Ben Miled
Mohamed
M
Ktari
Sonia
S
Daoud
Lilia
L
Ben Rhouma
Samir
S
Ben Amor
Golsom
G
Chérif
Ouahida
O
Rokbani
Lilia
L
D000906:Antibodies / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000276:immunology*
D000906:Antibodies; D014409:Tumor Necrosis Factor-alpha