title: An A > G polymorphism at position -670 in the Fas (TNFRSF6) gene in pregnant women with pre-eclampsia and intrauterine growth restriction.
abstract: Fas-mediated apoptosis of maternal lymphocytes during pregnancy has been postulated to prevent the development of pre-eclampsia. A single adenine (A) to guanine (G) polymorphism at position -670 in the Fas gene (TNFRSF6) results in decreased Fas synthesis. The association between this polymorphism and pre-eclampsia in Hungarian women was investigated. In a case-control study, buccal swabs from 38 pregnant women with pre-eclampsia and 89 normotensive controls were analysed for the TNFRSF6-670 polymorphism. Investigators were blinded to clinical outcomes. Maternal homozygosity for the TNFRSF6-670*A occurred in 33 (37.1%) normotensive pregnant women as compared to only 5 (16.1%) of 31 pre-eclamptic pregnant women who delivered at < 37 weeks gestation (P = 0.04). The carriage rate of the TNFRSF6-670*G variant was also higher among these patients (59.7%) than among normotensive controls (42.1%; P = 0.01). There was no relation between the polymorphism and the pre-eclampsia diagnosed at > or = 37 weeks. Among pre-eclamptic patients with an intrauterine growth restriction (IUGR) neonate, eight (57.2%) were TNFRSF6-670*G homozygous as opposed to 3 (17.6%) of 17 pre-eclamptics who did not have IUGR (P = 0.03) and 19 (21.3%) normotensive controls (P = 0.008). Carriage of the TNFRSF6-670 polymorphism in the neonate was not associated with pre-eclampsia or IUGR. Maternal possession of the TNFRSF6-670*G increases the risk for pre-eclampsia and pre-eclampsia-associated IUGR in women who deliver at < 37 weeks.
authors.affiliation: First Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary.
authors.forename: Istvan
authors.initials: I
authors.lastname: Sziller
authors.forename: Daniel
authors.initials: D
authors.lastname: Nguyen
authors.forename: Amrita
authors.initials: A
authors.lastname: Halmos
authors.forename: Petronella
authors.initials: P
authors.lastname: Hupuczi
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Papp
authors.forename: Steven S
authors.initials: SS
authors.lastname: Witkin
mesh_terms: D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D006801:Humans; D006814:Hungary; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics*; D019014:fas Receptor
chemical_list: C491901:FAS protein, human; D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor