[High molecular weight chitosan and sodium alginate effect on secretory acid proteinase of Candida albicans].
The effect of high molecular weight chitosan (HMWCh) and sodium alginate (NaAL) on acid proteinase secretion of Candida albicans (one of culture collection and five isolates) was evaluated. The secretion of acid proteinase was induced in the presence and the absence of these polymers in different concentrations and their enzymatic activity was determined. HMWCh and NaAL significantly diminished the enzymatic activity (>76% for the collection strains and > 89% for the isolates, p < 0.05). HMWCh did not modify protein concentrations, but NaAL did. It can be concluded that both polymers can inhibit the proteinase activity of Candida albicans.
Calamari
Silvia
S
Departamento de Biología Bucal, Facultad de Odontología, Ciudad Universitaria Haya de la Torre, Cordoba, Argentina.
Bojanich
Alejandra
A
Barembaum
Silvina
S
Azcurra
Ana
A
Virga
Carolina
C
Dorronsoro
Susana
S
D000464:Alginates / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000201:enzymology / Q000472:pathogenicity; D002180:Candidiasis, Oral / Q000382:microbiology / Q000517:prevention & control; D002448:Cell Adhesion; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D010450:Endopeptidases / Q000378:metabolism*; D005656:Fungal Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020723:Glucuronic Acid / Q000494:pharmacology*; D006603:Hexuronic Acids / Q000494:pharmacology*; D006801:Humans; D008970:Molecular Weight; D011480:Protease Inhibitors / Q000494:pharmacology*
D000464:Alginates; D005656:Fungal Proteins; D006603:Hexuronic Acids; D011480:Protease Inhibitors; D020723:Glucuronic Acid; D048271:Chitosan; D010450:Endopeptidases; C062596:Candida albicans producing proteinase