A new strategy for solid-phase depsipeptide synthesis using recoverable building blocks.
The technique of choice for synthesis of small-scale depsipeptides is on a solid support. However, if expensive monomers have to be incorporated, solid-phase synthesis can quickly turn out to be unattractive because of its low atom economy. Herein, we describe a new type of recoverable and reuseable alpha-hydroxy acid building block for solid-phase synthesis and its application in the synthesis of a number of small cyclic depsipeptides. [structure: see text]
Albericio
Fernando
F
Barcelona Biomedical Research Institute, Barcelona Science Park, University of Barcelona, 08028 Barcelona, Spain. albericio@pcb.ub.es
Burger
Klaus
K
Ruíz-Rodríguez
Javier
J
Spengler
Jan
J
D000596:Amino Acids; D002264:Carboxylic Acids; D047630:Depsipeptides / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008958:Models, Molecular
D000596:Amino Acids; D002264:Carboxylic Acids; D047630:Depsipeptides; D007202:Indicators and Reagents