Are proteins made from a limited parts list?
Understanding the process of protein folding has been recognized as an important challenge for >70 years. It is, quintessentially, a thermodynamic problem and, arguably, thermodynamics is our most powerful discipline for understanding biological systems. Yet, despite all this, we still lack predictive understanding of protein folding. Is something missing from this picture?
Fitzkee
Nicholas C
NC
Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
Fleming
Patrick J
PJ
Gong
Haipeng
H
Panasik
Nicholas
N
Street
Timothy O
TO
Rose
George D
GD
D000465:Algorithms; D006860:Hydrogen Bonding; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
D010455:Peptides; D011506:Proteins; D014867:Water; C011083:polyproline