title: A method for determining intracellular concentrations of enzyme substrates from a combination of competitive inhibition and mutagenesis studies.
authors.affiliation: Department of Enzymology and Mechanistic Pharmacology and Department of Oncology Biology, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. robert.a.copeland@gsk.com
authors.forename: Robert A
authors.initials: RA
authors.lastname: Copeland
authors.forename: Lusong
authors.initials: L
authors.lastname: Luo
authors.forename: Kurt R
authors.initials: KR
authors.lastname: Auger
authors.forename: Pearl S
authors.initials: PS
authors.lastname: Huang
mesh_terms: D001667:Binding, Competitive; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology; D004798:Enzymes / Q000235:genetics / Q000378:metabolism*; D042541:Intracellular Space / Q000201:enzymology / Q000378:metabolism*; D007700:Kinetics; D008024:Ligands; D016296:Mutagenesis
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes; D008024:Ligands