Preganglionic parasympathectomy decreases salivary SIgA secretion rates from the rat submandibular gland.
Immunoglobulin A (IgA) is transported into saliva by salivary cells expressing the polymeric immunoglobulin receptor (pIgR). In rat salivary glands, autonomic nerves stimulate this process. To examine how nerves affect pIgR-mediated IgA secretion, the chorda-lingual nerve was sectioned. One week after preganglionic parasympathectomy, both the stimulated and unstimulated rates of salivary IgA secretion were reduced, despite similar glandular amounts of IgA. Biochemical analysis of cells from parasympathectomised and control glands indicated reduced membrane expression of pIgR. It appears the removal of long-term parasympathetic input has affected the routing of pIgR within salivary cells and reduced the SIgA transport into saliva.
Carpenter
G H
GH
Salivary Research Group, Division Oral Medicine, Guy's King's and St Thomas' School of Dentistry, United Kingdom. Guy.carpenter@kcl.ac.uk
Proctor
G B
GB
Garrett
J R
JR
D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000502:physiology*; D002469:Cell Separation; D015536:Down-Regulation / Q000276:immunology*; D007070:Immunoglobulin A / Q000096:biosynthesis; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis*; D008036:Lingual Nerve / Q000601:surgery; D008297:Male; D009929:Organ Size / Q000276:immunology; D017764:Parasympathectomy / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012463:Saliva / Q000276:immunology* / Q000378:metabolism*; D012471:Salivary Proteins and Peptides / Q000096:biosynthesis / Q000378:metabolism; D012635:Secretory Component / Q000096:biosynthesis; D013363:Submandibular Gland / Q000276:immunology* / Q000294:innervation* / Q000378:metabolism / Q000601:surgery
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D012471:Salivary Proteins and Peptides; D012635:Secretory Component