Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agents.
Mitscher
Lester A
LA
Department of Medicinal Chemistry and Molecular Biosciences and The Chemical Methodologies and Library Development Center of Excellence, The University of Kansas, Lawrence, Kansas 66045-7582, USA. lmitscher@ku.edu
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D004250:DNA Topoisomerases, Type II / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics / Q000502:physiology; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011728:Pyridones / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D015363:Quinolones / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
D000900:Anti-Bacterial Agents; D011728:Pyridones; D015363:Quinolones; D059005:Topoisomerase II Inhibitors; D004250:DNA Topoisomerases, Type II