title: Regression analysis of restricted mean survival time based on pseudo-observations.
abstract: Regression models for survival data are often specified from the hazard function while classical regression analysis of quantitative outcomes focuses on the mean value (possibly after suitable transformations). Methods for regression analysis of mean survival time and the related quantity, the restricted mean survival time, are reviewed and compared to a method based on pseudo-observations. Both Monte Carlo simulations and two real data sets are studied. It is concluded that while existing methods may be superior for analysis of the mean, pseudo-observations seem well suited when the restricted mean is studied.
authors.affiliation: Department of Biostatistics, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark. pka@biostat.ku.dk
authors.forename: Per Kragh
authors.initials: PK
authors.lastname: Andersen
authors.forename: Mette Gerster
authors.initials: MG
authors.lastname: Hansen
authors.forename: John P
authors.initials: JP
authors.lastname: Klein
mesh_terms: D001699:Biometry; D006801:Humans; D015993:Life Tables; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000401:mortality; D015233:Models, Statistical; D009010:Monte Carlo Method; D019370:Observation; D011241:Prednisone / Q000627:therapeutic use; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D011241:Prednisone