Synthesis and pharmacological evaluation of substituted 5-[4-[2-(6,7-dimethyl-1,2,3,4-tetrahydro-2-oxo-4-quinoxalinyl)ethoxy]phenyl]methylene]thiazolidine-2,4-dione derivatives as potent euglycemic and hypolipidemic agents.
A series of substituted 5-[4-[2-(6,7-dimethyl-1,2,3,4-tetrahydro-2-oxo-4-quinoxalinyl)ethoxy]phenyl]methylene]thiazolidine-2,4-diones were synthesized and their euglycemic and hypolipidemic activities were investigated in Wistar male rats. Based on the in vivo data in rats, compound 4a was identified as a potent euglycemic and hypolipidemic agent.
Gupta
Dipti
D
Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India.
Ghosh
Narendra Nath
NN
Chandra
Ramesh
R
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008055:Lipids / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000494:pharmacology*
D001786:Blood Glucose; D000960:Hypolipidemic Agents; D008055:Lipids; D045162:Thiazolidinediones