title: Peripheral survival of naïve CD8+ T cells.
abstract: Maintenance of a sufficient population of naive CD8+ T cells in the peripheral lymphoid compartment is critical for immunocompetence. Peripheral T cell number is a function of T cell generation, survival, and death. Homeostasis, a critical balance between survival and death, must exist to prevent either lymphopenia or lymphocytosis. In the current review, we discuss known requirements for the survival of naive peripheral CD8+ T cells as well as mechanisms of death when survival signals are lost. We also discuss associations between survival and homeostasis-driven proliferation, and highlight the gaps in our knowledge of these critical processes.
authors.affiliation: Department of Pathology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA.
authors.forename: I E
authors.initials: IE
authors.lastname: Brown
authors.forename: M
authors.initials: M
authors.lastname: Mashayekhi
authors.forename: M
authors.initials: M
authors.lastname: Markiewicz
authors.forename: M-L
authors.initials: ML
authors.lastname: Alegre
authors.forename: T F
authors.initials: TF
authors.lastname: Gajewski
mesh_terms: D000818:Animals; D016827:CD8 Antigens / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D049109:Cell Proliferation; D002470:Cell Survival / Q000276:immunology; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology*; D008954:Models, Biological
chemical_list: D016827:CD8 Antigens