title: Effects of low and high intra-abdominal pressure on immune response in laparoscopic cholecystectomy.
abstract: OBJECTIVE
  Immunosuppression is directly related to the degree of trauma. The aim of this study is to compare the effects of low and high intra-abdominal pressure on immune response in moderate surgical trauma.
  
  
  METHODS
  Twenty-two patients, scheduled for laparoscopic cholecystectomy, were randomly allocated to one of 2 groups according to intra-abdominal pressure: low and high intra-abdominal pressure. This study was conducted in the Hacettepe University Faculty of Medicine, Operation Room, Ankara, Turkey. Serum interleukin (IL)-2 and IL-6 levels were measured.
  
  
  RESULTS
  Serum IL-2 showed a significant decrease before the incision in high intra-abdominal pressure group. The increase in serum IL-6 at the end of surgery and postoperatively was lower in low intra-abdominal pressure group.
  
  
  CONCLUSIONS
  These results, can be interpreted as the immune system, are less depressed when there is lower intra-abdominal pressure. This may have clinical implications in immunocompromised patients.
authors.affiliation: Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Basgul
authors.forename: Betul
authors.initials: B
authors.lastname: Bahadir
authors.forename: Varol
authors.initials: V
authors.lastname: Celiker
authors.forename: Ayse H
authors.initials: AH
authors.lastname: Karagoz
authors.forename: Erhan
authors.initials: E
authors.lastname: Hamaloglu
authors.forename: Ulku
authors.initials: U
authors.lastname: Aypar
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D017081:Cholecystectomy, Laparoscopic / Q000379:methods*; D005260:Female; D006801:Humans; D006874:Hydrostatic Pressure; D007108:Immune Tolerance / Q000276:immunology; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011028:Pneumoperitoneum, Artificial / Q000379:methods*; D011183:Postoperative Complications / Q000276:immunology*
chemical_list: D007376:Interleukin-2; D015850:Interleukin-6