title: Zygomycosis after prolonged use of voriconazole in immunocompromised patients with hematologic disease: attention required.
abstract: We describe 4 cases of zygomycosis that occurred after prolonged use of voriconazole in severely immunocompromised patients with hematologic disease. An invasive infection was present in 3 patients who died soon after the diagnosis at 12, 13, and 45 days. Physicians should be mindful of this potential risk after treatment with voriconazole.
authors.affiliation: Service d'Hematologie Clinique, CHU Hotel Dieu, Nantes, France. vigouroux.st@wanadoo.fr
authors.forename: Stéphane
authors.initials: S
authors.lastname: Vigouroux
authors.forename: Odile
authors.initials: O
authors.lastname: Morin
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreau
authors.forename: Françoise
authors.initials: F
authors.lastname: Méchinaud
authors.forename: Nadine
authors.initials: N
authors.lastname: Morineau
authors.forename: Béatrice
authors.initials: B
authors.lastname: Mahé
authors.forename: Patrice
authors.initials: P
authors.lastname: Chevallier
authors.forename: Thierry
authors.initials: T
authors.lastname: Guillaume
authors.forename: Viviane
authors.initials: V
authors.lastname: Dubruille
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Harousseau
authors.forename: Noël
authors.initials: N
authors.lastname: Milpied
mesh_terms: D020095:Absidia / Q000302:isolation & purification; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality / Q000601:surgery; D011743:Pyrimidines / Q000627:therapeutic use*; D020103:Rhizomucor / Q000302:isolation & purification; D012233:Rhizopus / Q000302:isolation & purification; D013997:Time Factors; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole