Mitochondrial Ca2+ homeostasis in health and disease.
Although it has long been known that mitochondria possess a complex molecular repertoire for accumulating and releasing Ca2+, only in recent years has a large body of data demonstrated that these organelles promptly respond to Ca(2+)-mediated cell stimulations. In this contribution, we will review the principles of mitochondrial Ca2+ homeostasis and its signaling role in different physiological and pathological conditions.
Campanella
Michelangelo
M
Dept. Experimental and Diagnostic Medicine, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Italy.
Pinton
Paolo
P
Rizzuto
Rosario
R
D017209:Apoptosis / Q000502:physiology*; D001692:Biological Transport / Q000502:physiology; D002118:Calcium / Q000378:metabolism* / Q000502:physiology; D015220:Calcium Channels / Q000378:metabolism* / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism / Q000502:physiology; D008928:Mitochondria / Q000502:physiology*
D015220:Calcium Channels; D002118:Calcium