[Evaluation of biological safety of continuous carbon-fiber reinforced polyolefin as hard tissue repair].
OBJECTIVE
To evaluate the biological safety of continuous carbon-fiber reinforced polyolefin as hard tissue repair material.


METHODS
Biocompatibility of the material was evaluated through hemolysis test, pyrogen test, skin irritation test, cytotoxicity test, ames test, in vitro chromosome aberration test, and bone marrow cells Micronuclei test.


RESULTS
No obvious hemolysis, pyrogenic characteristics, sensitivity, cytotoxicity, and mutagenicity were observed.


CONCLUSIONS
The continuous carbon-fiber reinforced polyolefin composite material is of good biological safety. It meets all the demand made by biological safety as hard tissue repair material.
Hou
Chunlin
C
Department of Orthopeadic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P R China. chunlin-hou@yahoo.com.cn
Feng
Xue
X
Cen
Qingquan
Q
Zhang
Wei
W
Yang
Guisheng
G
Sun
Jiao
J
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000633:toxicity*; D002244:Carbon / Q000737:chemistry / Q000633:toxicity*; D000077482:Carbon Fiber; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects; D008422:Materials Testing; D051379:Mice; D011090:Polyenes / Q000737:chemistry / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D018675:Toxicity Tests
D001672:Biocompatible Materials; D000077482:Carbon Fiber; D011090:Polyenes; D002244:Carbon; C035051:PL 732