Trisomy 11 in myeloid malignancies is associated with internal tandem duplication of both MLL and FLT3 genes.
In 20 patients with myeloid malignancies and isolated trisomy 11 an internal tandem duplication of the MLL and FLT3 genes was observed in 41% and 31% of the cases, respectively; 80% of the FLT3+ cases showed MLL self-fusion. Concomitant presence of MLL and FLT3 anomalies could be relevant in determining the poor outcome of patients with acute myeloid leukemia with trisomy 11.
Rege-Cambrin
Giovanna
G
Giugliano
Emilia
E
Michaux
Lucienne
L
Stul
Michel
M
Scaravaglio
Patrizia
P
Serra
Anna
A
Saglio
Giuseppe
G
Hagemeijer
Anne
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002880:Chromosomes, Human, Pair 11; D020440:Gene Duplication; D015972:Gene Expression Regulation, Neoplastic; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008875:Middle Aged; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D013997:Time Factors; D014314:Trisomy; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3