The effect of sustained heavy exercise on the development of pulmonary edema in trained male cyclists.
To determine whether intense, prolonged activity can induce transient pulmonary edema, eight highly trained male cyclists (mean +/- S.D.: age, 26.9 +/- 3.0 years; height, 179.9 +/- 5.7 cm; weight, 76.1 +/- 6.5 kg) performed a 45-min endurance cycle test (ECT). V(O2,max) was determined (4.84 +/- 0.4 L min(-1), 63.7 +/- 2.6 ml min(-1) g(-1)) and the intensity of exercise for the ECT was set at 10% below ventilatory threshold (approximately 76% V(O2, max) 300 +/- 25 W). Pre- and post-exercise pulmonary diffusion (DL(CO)) measurements and magnetic resonance imaging of the lung were made. DL(CO) and pulmonary capillary blood volume (VC) decreased 1h post-exercise by 12% (P = 0.004) and 21% (P = 0.017), respectively, but no significant change in membrane diffusing capacity (DM) was found. The magnetic resonance scans demonstrated a 9.4% increase (P = 0.043) in pulmonary extravascular water 90 min post-exercise. These data support the theory that high intensity, sustained exercise in well-trained athletes can result in transient pulmonary edema.
McKenzie
D C
DC
Allan McGavin Sports Medicine Centre and School of Human Kinetics, The University of British Columbia, 3055 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3. kari@interchange.ubc.ca
O'Hare
T J
TJ
Mayo
J
J
D000328:Adult; D001642:Bicycling / Q000293:injuries*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D010807:Physical Endurance / Q000502:physiology*; D011653:Pulmonary Diffusing Capacity / Q000502:physiology; D011654:Pulmonary Edema / Q000473:pathology / Q000503:physiopathology*; D011659:Pulmonary Gas Exchange; D012129:Respiratory Function Tests / Q000379:methods; D014692:Ventilation-Perfusion Ratio