title: [Experimental study on protecting intestinal barrier function of Huoxiang Zhengqi soft capsule].
abstract: OBJECTIVE
  To study the effect of Huoxiang Zhengqi soft capsule on protecting intestinal barrier.
  
  
  METHODS
  Lower limb ischemic reperfusion model was induced in Wistar rats. The Chinese medicine groups were administered orally with Huoxiang Zhengqi soft capsule before inoculation respectively. The small intestinal histopathology and ultrastructural of rats were observed with optical microscope and electronic microscope respectively. Mucus was observed under AB-PAS staining, mast cells were studied under toluidine blue staining, and serum NO was determined.
  
  
  RESULTS
  After Lower limb ischemic reperfusion, the intestinal barrier function was severely damaged. Huoxiang Zhengqi soft capsule could significantly reduce the levels of the serum NO (P < 0.01).
  
  
  CONCLUSIONS
  Huoxiang Zhengqi soft capsule has apparent protective effect on the intestinal barrier function in lower limb ischemic reperfusion rats.
authors.affiliation: General Hospital of Tianjin Medical University, Tianjin 300052, China.
authors.forename: Yi-chong
authors.initials: YC
authors.lastname: Xie
authors.forename: Fang
authors.initials: F
authors.lastname: Tang
mesh_terms: D000818:Animals; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006614:Hindlimb / Q000098:blood supply*; D007082:Ileum / Q000473:pathology*; D007413:Intestinal Mucosa / Q000473:pathology / Q000648:ultrastructure; D007511:Ischemia / Q000150:complications; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D009093:Mucus / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology*
chemical_list: D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D020011:Protective Agents