[Cases report and literature review of laryngeal amyloidosis].
OBJECTIVE
To have a better understand about mechanism, classification, clinical manifestation, diagnosis and treatment of the laryngeal amyloidosis.


METHODS
Among 11 cases of clinical material of patients suffering from laryngeal amyloidosis, 5 cases operated by indirect laryngoscope, 1 case by direct laryngoscope, 2 cases by laryngofissure, 1 case by vertical hemilaryngectomy with glottis reconstruction, 2 cases weren't operated.


RESULTS
Three cases lost follow-up, 2 cases were recurred, and 6 cases' condition remained stable.


CONCLUSIONS
(1) Symmers' classification is generally accepted and has clinical value; (2) The Congo red staining is the classic and most specific histochemical test, the fibrils demonstrate characteristic apple-green birefringence when examined under polarized light microscopy, which provide basis on confirming the diagnosis. (3) Laryngeal amyloidosis usually indicated localized disease with systemic and secondary involvement uncommon, however, potential for an underlying disease state such as multiple myeloma, a full medical evaluation for systemic disease should be performed. (4) Management depends on the severity of the symptoms in regard to the individual patients and in some case, can be conservative observation. If disease is causing significant symptom or showing signs of increasing in size, surgical intervention must be carried out. (5) Recurrence maybe become manifested after several years and long-term follow-up is recommended.
Ji
Xiaobin
X
Department of Otolaryngology, Guangzhou First Peoples Hospital, Guangzhou, 510180, China.
Liang
Cifang
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods; D008297:Male; D008875:Middle Aged