title: Bone mineral density and markers of bone turnover in boys with constitutional delay of growth and puberty.
abstract: It has been suggested that poor growth in childhood or puberty might be a correctable determinant of osteoporosis. To assess the effect of the growth and puberty delay on bone metabolism, we measured bone mineral density (BMD) and markers of bone turnover in 41 boys with constitutional delay of growth and puberty. Total body (TB) and lumbar spine (LS) BMD were measured by dual-energy x-ray absorptiometry. Serum osteocalcin, total alkaline phosphatase, and urinary deoxypyridinoline cross-links as markers of bone turnover were evaluated. BMD was decreased by at least 1 sd in TB in 23 boys (56%) and in LS in 27 boys (66%). After adjustment of BMD for bone age, TB was decreased in 11 boys (27%) and LS in 13 boys (32%). Bone age and chronological age significantly correlated with areal and volumetric BMD. The significant increments of height, weight, TB, and LS BMD between the consecutive pubertal stages were reported. Mean alkaline phosphatase, osteocalcin, and deoxypyridinoline were within reference ranges and showed no differences between pubertal stages. In conclusion, in boys with constitutional delay of growth and puberty, bone turnover is normal, and BMD increases in a manner similar to healthy children.
authors.affiliation: Department of Propaedeutics in Pediatrics, Hypertension and Metabolic Diseases, Pomeranian Medical University, ul. Arkońska 4, 71-455 Szczecin, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Krupa
authors.forename: Tomasz
authors.initials: T
authors.lastname: Miazgowski
mesh_terms: D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers; D015519:Bone Density; D016723:Bone Remodeling; D002648:Child; D006130:Growth Disorders / Q000378:metabolism*; D006801:Humans; D008297:Male; D015675:Osteocalcin / Q000097:blood; D011628:Puberty, Delayed / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D015675:Osteocalcin; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase