title: A glucosamine-dipicolylamine conjugate of 99mTc(I) and 186Re(I) for use in imaging and therapy.
abstract: The synthesis and metal complexation of a glucosamine-appended 2,2'-dipicolylamine ligand to the tricarbonyls of 99mTc and 186Re is described; the ligand was found to bind in a tridentate fashion with the glucosamine function remaining pendant, and the 99mTc complex was found to exhibit exceptional stability towards in vitro ligand exchange experiments.
authors.affiliation: Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 2A3, Canada.
authors.forename: Tim
authors.initials: T
authors.lastname: Storr
authors.forename: Cara L
authors.initials: CL
authors.lastname: Fisher
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mikata
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Yano
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Adam
authors.forename: Chris
authors.initials: C
authors.lastname: Orvig
mesh_terms: D000588:Amines / Q000737:chemistry*; D005944:Glucosamine / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D015609:Organotechnetium Compounds / Q000737:chemistry*; D010848:Picolinic Acids / Q000737:chemistry*; D016719:Radioimmunodetection; D011868:Radioisotopes; D012211:Rhenium / Q000737:chemistry*
chemical_list: C501847:2,2'-dipicolylamine; D000588:Amines; D008024:Ligands; D015609:Organotechnetium Compounds; D010848:Picolinic Acids; D011868:Radioisotopes; D012211:Rhenium; D005944:Glucosamine