title: A primary Sjögren's syndrome patient with distal renal tubular acidosis, who presented with symptoms of hypokalemic periodic paralysis: Report of a case study and review of the literature.
abstract: Although renal tubular acidosis (RTA), secondary to autoimmune interstitial nephritis, develops in a large proportion of patients with Sjögren's syndrome (SS), most of the subjects are asymptomatic. Here, we shall present a 39-year-old female patient who came to us with hypokalemic periodic paralysis (HPP), and who was later diagnosed with distal RTA. The patient, who had xerostomia and xerophthalmia for a long period of time, was diagnosed with primary SS from serologic and histologic findings. The patient recovered by being prescribed potassium replacement therapy. Although renal biopsy was not performed, corticosteroids were administered because HPP indicated severe interstitial nephritis. HPP did not reoccur during a 2-year follow-up period. We also review cases with SS-related distal RTA and HPP.
authors.affiliation: Department of Rheumatology, Trakya Medical Faculty, University of Trakya, Edirne, Turkey. msoy_2000@yahoo.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Soy
authors.forename: Omer Nuri
authors.initials: ON
authors.lastname: Pamuk
authors.forename: Murat
authors.initials: M
authors.lastname: Gerenli
authors.forename: Yahya
authors.initials: Y
authors.lastname: Celik
mesh_terms: D000141:Acidosis, Renal Tubular / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D020514:Hypokalemic Periodic Paralysis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D008775:Methylprednisolone / Q000627:therapeutic use; D011188:Potassium / Q000008:administration & dosage; D011191:Potassium Deficiency / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome; D014985:Xerophthalmia / Q000209:etiology / Q000473:pathology; D014987:Xerostomia / Q000209:etiology / Q000473:pathology
chemical_list: D018501:Antirheumatic Agents; D006886:Hydroxychloroquine; D011188:Potassium; D008775:Methylprednisolone