[Effect of Spatholobus suberectus on the bone marrow cells and related cytokines of mice].
OBJECTIVE
To study the effect of Spatholobus suberectus on proliferation and the hematonic mechanism.


METHODS
The techniques of culture of hematopoietic cell and hematopoietic growth factor (HGF) assay were used.


RESULTS
Spatholobus suberectus could obviously promote the proliferation of bone marrow cells in healthy and anaemic mice. The culture media of spleen cell, macrophage, lung and skeletal muscle treated with S. suberectus had much stronger stimulating effects on hematopoietic cells.


CONCLUSIONS
S. suberectus may enhance hematopoiesis by directly or indirectly stimulating stroma cell in hematopoietic inductive microenvironment and muscle tissue to secrete some HGF (Epo, GM-CSF, IL, and MK-CSF). This is one of the biological mechanisms for hematonic effect of S. suberectus.
Chen
Dong-hui
DH
Sichuan University, Chengdu 610064, China.
Luo
Xia
X
Yu
Meng-yao
MY
Zhao
Yi-qing
YQ
Cheng
Yao-feng
YF
Yang
Zhi-rong
ZR
D000740:Anemia / Q000473:pathology; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D049109:Cell Proliferation / Q000187:drug effects; D003115:Colony-Stimulating Factors / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry; D005260:Female; D008297:Male; D051379:Mice; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
D003115:Colony-Stimulating Factors; D004365:Drugs, Chinese Herbal