title: Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease.
abstract: Dysfunction of neostriatal medium spiny neurons (MSNs) is hypothesized to underlie late-stage motor complications of Parkinson disease (PD). The authors demonstrate shortened dendrite length of MSNs that was similar in four regions of neostriatum in late-stage PD. In contrast, MSN dendrite spine degeneration was unevenly distributed with the greatest loss in caudal putamen. The authors propose that these structural changes in MSN may contribute to late-stage motor complications of PD.
authors.affiliation: Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA.
authors.forename: S
authors.initials: S
authors.lastname: Zaja-Milatovic
authors.forename: D
authors.initials: D
authors.lastname: Milatovic
authors.forename: A M
authors.initials: AM
authors.lastname: Schantz
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: K S
authors.initials: KS
authors.lastname: Montine
authors.forename: A
authors.initials: A
authors.lastname: Samii
authors.forename: A Y
authors.initials: AY
authors.lastname: Deutch
authors.forename: T J
authors.initials: TJ
authors.lastname: Montine
mesh_terms: D000368:Aged; D001284:Atrophy; D003712:Dendrites / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017072:Neostriatum / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D010300:Parkinson Disease / Q000473:pathology*