title: New frontiers in translational research in neuro-oncology and the blood-brain barrier: report of the tenth annual Blood-Brain Barrier Disruption Consortium Meeting.
abstract: The blood-brain barrier (BBB) presents a major obstacle to the treatment of malignant brain tumors and other central nervous system (CNS) diseases. For this reason, a meeting partially funded by an NIH R13 grant was convened to discuss recent advances and future directions in translational research in neuro-oncology and the BBB. Cell biology and transport across the BBB, delivery of agents to the CNS, neuroimaging, angiogenesis, immunotherapy, and gene therapy, as well as glioma, primary CNS lymphoma, and metastases to the CNS were discussed. Transport across the BBB relates to the neurovascular unit, which consists not only of endothelial cells but also of pericyte, glia, and neuronal elements.
authors.affiliation: Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA.
authors.forename: Nancy D
authors.initials: ND
authors.lastname: Doolittle
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Abrey
authors.forename: W Archie
authors.initials: WA
authors.lastname: Bleyer
authors.forename: Steven
authors.initials: S
authors.lastname: Brem
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Davis
authors.forename: Paula
authors.initials: P
authors.lastname: Dore-Duffy
authors.forename: Lester R
authors.initials: LR
authors.lastname: Drewes
authors.forename: Walter A
authors.initials: WA
authors.lastname: Hall
authors.forename: John M
authors.initials: JM
authors.lastname: Hoffman
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Korfel
authors.forename: Robert
authors.initials: R
authors.lastname: Martuza
authors.forename: Leslie L
authors.initials: LL
authors.lastname: Muldoon
authors.forename: David
authors.initials: D
authors.lastname: Peereboom
authors.forename: Darryl R
authors.initials: DR
authors.lastname: Peterson
authors.forename: Samuel D
authors.initials: SD
authors.lastname: Rabkin
authors.forename: Quentin
authors.initials: Q
authors.lastname: Smith
authors.forename: Glen H J
authors.initials: GH
authors.lastname: Stevens
authors.forename: Edward A
authors.initials: EA
authors.lastname: Neuwelt
mesh_terms: D000970:Antineoplastic Agents; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003131:Combined Modality Therapy; D016503:Drug Delivery Systems; D004343:Drug Implants; D006801:Humans; D008279:Magnetic Resonance Imaging; D008495:Medical Oncology; D009462:Neurology
chemical_list: D000970:Antineoplastic Agents; D004343:Drug Implants