Immunolocalisation of bilitranslocase in mucosecretory and parietal cells of the rat gastric mucosa.
Bilitranslocase is a plasma membrane carrier localised at the vascular pole of the rat liver cell, where it mediates uptake of organic anions from the blood into the liver. This carrier is also present in the epithelium of the rat gastric mucosa, with similar molecular mass and functional properties. An immunohistochemical study reveals that both the mucus-secreting cells of the gastric pit and the H+-secreting parietal cells express bilitranslocase. These data point to a possible role of bilitranslocase and of its food-borne substrates (anthocyanins and nicotinic acid) in regulating the function and the permeability of the gastric mucosa.
Nicolin
Vanessa
V
Dipartimento di Morfologia Umana Normale, Università degli Studi di Trieste, via A. Manzoni 16, 34138, Trieste, Italia.
Grill
Vittorio
V
Micali
Fulvio
F
Narducci
Paola
P
Passamonti
Sabina
S
D000818:Animals; D002570:Ceruloplasmin; D005753:Gastric Mucosa / Q000166:cytology / Q000201:enzymology*; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000032:analysis* / Q000276:immunology; D010295:Parietal Cells, Gastric / Q000201:enzymology* / Q000648:ultrastructure; D051381:Rats
D008565:Membrane Proteins; D002570:Ceruloplasmin; C033838:bilitranslocase