title: [Clarithromycin resistance of Helicobacter pylori strains isolated from antral biopsy specimens].
abstract: Helicobacter pylori is the main causative agent of peptic ulcer disease. Clarithromycin resistance in H. pylori is one of the common causes of failure of the eradication therapy based on the use of amoxicillin-clarithromycin and proton pump inhibitors. In this study, 78 H. pylori strains isolated from antral biopsy specimens of dyspeptic patients have been tested for susceptibility to clarithromycin, with NCCLS approved agar dilution and the E-test methods. Sixteen (20.5%) of the strains were found resistant to clarithromycin, and the resistance rates were similar obtained by E-test and agar dilution method. The high rate of clarithromycin resistance among H. pylori strains in our study population, may give a direction to follow-up of the eradication therapy and to define regional treatment policies.
authors.affiliation: Başkent Universitesi Tip Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Ankara.
authors.forename: Füsun
authors.initials: F
authors.lastname: Can
authors.forename: Müge
authors.initials: M
authors.lastname: Demirbilek
authors.forename: Haldun
authors.initials: H
authors.lastname: Selçuk
authors.forename: Hande
authors.initials: H
authors.lastname: Arslan
authors.forename: Sedat
authors.initials: S
authors.lastname: Boyacioğlu
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001706:Biopsy; D017291:Clarithromycin / Q000494:pharmacology*; D004415:Dyspepsia / Q000150:complications / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000382:microbiology; D011706:Pyloric Antrum / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin