title: [Evaluation of biological safety of continuous carbon-fiber reinforced polyolefin as hard tissue repair].
abstract: OBJECTIVE
  To evaluate the biological safety of continuous carbon-fiber reinforced polyolefin as hard tissue repair material.
  
  
  METHODS
  Biocompatibility of the material was evaluated through hemolysis test, pyrogen test, skin irritation test, cytotoxicity test, ames test, in vitro chromosome aberration test, and bone marrow cells Micronuclei test.
  
  
  RESULTS
  No obvious hemolysis, pyrogenic characteristics, sensitivity, cytotoxicity, and mutagenicity were observed.
  
  
  CONCLUSIONS
  The continuous carbon-fiber reinforced polyolefin composite material is of good biological safety. It meets all the demand made by biological safety as hard tissue repair material.
authors.affiliation: Department of Orthopeadic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P R China. chunlin-hou@yahoo.com.cn
authors.forename: Chunlin
authors.initials: C
authors.lastname: Hou
authors.forename: Xue
authors.initials: X
authors.lastname: Feng
authors.forename: Qingquan
authors.initials: Q
authors.lastname: Cen
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Guisheng
authors.initials: G
authors.lastname: Yang
authors.forename: Jiao
authors.initials: J
authors.lastname: Sun
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000633:toxicity*; D002244:Carbon / Q000737:chemistry / Q000633:toxicity*; D000077482:Carbon Fiber; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects; D008422:Materials Testing; D051379:Mice; D011090:Polyenes / Q000737:chemistry / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D018675:Toxicity Tests
chemical_list: D001672:Biocompatible Materials; D000077482:Carbon Fiber; D011090:Polyenes; D002244:Carbon; C035051:PL 732