Ubidecarenone nanoemulsified composite systems.
The nanoemulsified composite (NEC) delivery system is a patented technology based on the incorporation of a double microemulsion into microporous carrier. This approach was applied on the very water insoluble ubidecarenone drug. The resulting composite powder showed good technological properties such as flowability; also good stability was evidentiated, with size of the nano-droplets released from the systems maintained equal to the starting size also after a long storage. Furthermore very good biopharmaceutical properties were originated, with water solubility concentrations up to 50-fold higher than pure ubidecarenone and oral absorption in rats up to three-fold greater than standard commercial products in terms of plasma levels and AUC.
Carli
F
F
Remedia Srl, Via J. Ressel, 2/7-34108 Dolina (Trieste), Italy.
Chiellini
E E
EE
Bellich
B
B
Macchiavelli
S
S
Cadelli
G
G
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000493:pharmacokinetics; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003067:Coenzymes; D004337:Drug Carriers / Q000008:administration & dosage / Q000493:pharmacokinetics; D004655:Emulsions; D036103:Nanotechnology / Q000379:methods*; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013997:Time Factors; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
D000975:Antioxidants; D003067:Coenzymes; D004337:Drug Carriers; D004655:Emulsions; D011208:Powders; D014451:Ubiquinone; C024989:coenzyme Q10