title: [Effect of oral beta2-stimulant on pulmonary function in asthma patients treated with multiple medications].
abstract: This study was designed to evaluate the effect of discontinuing oral beta2-stimulant in patients with asthma who were being treated with multiple medications. Thirty-two asthmatics controlled under multiple medications who had a stable PEF were entered. Patient symptoms, PEF, FEV10, V75,V50, and V25 were evaluated before and after discontinuing beta2-stimulant. Results showed that after discontinuing beta2-stimulant, there was little change in symptoms, PEF, or FEV10, and only two patients had to be re-medicated with oral beta2-stimulant. However, deterioration of V50 and V25 were clearly observed, suggesting that oral beta2-stimulant had an affect on dilatation of the small airway. Based on our data, we should regard that when discontinuing oral beta2-stimulant from combined use, the lung function reflecting the small airway decreases even if no change of symptoms is observed.
authors.affiliation: Department of Medical Informatics, Kagawa University Hospital.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Okada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Akihito
authors.initials: A
authors.lastname: Kubo
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Kitade
authors.forename: Shinya
authors.initials: S
authors.lastname: Tada
authors.forename: Nobuo
authors.initials: N
authors.lastname: Ueda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kamei
authors.forename: Jiro
authors.initials: J
authors.lastname: Fujita
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ogata
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate
chemical_list: D000318:Adrenergic beta-Agonists; D018927:Anti-Asthmatic Agents; D003692:Delayed-Action Preparations