Peripheral survival of naïve CD8+ T cells.
Maintenance of a sufficient population of naive CD8+ T cells in the peripheral lymphoid compartment is critical for immunocompetence. Peripheral T cell number is a function of T cell generation, survival, and death. Homeostasis, a critical balance between survival and death, must exist to prevent either lymphopenia or lymphocytosis. In the current review, we discuss known requirements for the survival of naive peripheral CD8+ T cells as well as mechanisms of death when survival signals are lost. We also discuss associations between survival and homeostasis-driven proliferation, and highlight the gaps in our knowledge of these critical processes.
Brown
I E
IE
Department of Pathology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL 60637, USA.
Mashayekhi
M
M
Markiewicz
M
M
Alegre
M-L
ML
Gajewski
T F
TF
D000818:Animals; D016827:CD8 Antigens / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D049109:Cell Proliferation; D002470:Cell Survival / Q000276:immunology; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology*; D008954:Models, Biological
D016827:CD8 Antigens