Clinical trial of a noninvasive contact lens glucose sensor.
OBJECTIVE
The purpose of the present study was to determine the effectiveness of a fluorescent contact lens glucose sensor in monitoring glucose in patients with diabetes.


METHODS
Under an institutional review board-approved protocol, five fasting patients with type II diabetes were given a challenge consisting of 75 mL of Sustacal (Thomson Micromedex, Greenwood, CO) by mouth. Contact lens fluorescence and venous blood glucose were measured over a 3-h period.


RESULTS
Contact lens fluorescence appeared to track blood glucose well. The fluorescent daily-wear disposable contact lenses were comfortable and were tolerated well, even in patients who had not previously worn contact lenses.


CONCLUSIONS
The contact lens glucose sensor shows promise as a home glucose monitor.
March
Wayne F
WF
Department of Ophthalmology, Downstate Health Science Center, State University of New York, Brooklyn, New York 11203-2098, USA. WFMarch47@aol.com
Mueller
Achim
A
Herbrechtsmeier
Peter
P
D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation / Q000379:methods; D003261:Contact Lenses; D005453:Fluorescence; D005947:Glucose / Q000032:analysis*; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods
D001786:Blood Glucose; D005947:Glucose