[The effect of hemantane on the generative function and gonad morphology in rats].
Effect of the new potential antiparkinsonian drug hemantane (N-(adamant-2-yl)hexamethyleneimine hydrochloride) on the generative function and gonad morphology was studied in a group of male and female mongrel rats. The generative function was studied after peroral drug administration in a dose of 10 mg/kg (ED50) and 50 mg/kg (5 ED50): males were treated over a 60-day period of spermatogenesis, while females received the drug in the same doses over 15 days (three estrous cycles). The gonad morphology was studied after a 6-month treatment of experimental animals with hemantane in the same doses. It was established that the administration hemantane in indicated doses did not influence the generative function and gonad morphology in male and female rats.
Smol'nikova
N M
NM
Nemova
E P
EP
Sorokina
A V
AV
Val'dman
E A
EA
Durnev
A D
AD
D000218:Adamantane / Q000009:adverse effects / Q000031:analogs & derivatives*; D000284:Administration, Oral; D000818:Animals; D000978:Antiparkinson Agents / Q000009:adverse effects*; D001381:Azepines / Q000009:adverse effects*; D005260:Female; D006066:Gonads / Q000187:drug effects* / Q000196:embryology; D008297:Male; D009866:Oogenesis / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects* / Q000502:physiology
D000978:Antiparkinson Agents; D001381:Azepines; C122112:N-(2-adamantyl)hexamethylenimine; D000218:Adamantane