Spiro-annulation of barbituric acid derivatives and its analogs by ring-closing metathesis reaction.
Barbituric acid 1 and related beta-dicarbonyl compounds were dialkenylated under the phase-transfer catalyst [e.g., benzyltriethylammonium chloride (BTEAC)] conditions to generate the diallylated products. These diallylated products were subjected to the ring-closing metathesis (RCM) reaction to deliver the corresponding spiro-annulated derivatives.
Kotha
Sambasivarao
S
Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai 400076, India.
Deb
Ashoke Chandra
AC
Kumar
Ramanatham Vinod
RV
D001463:Barbiturates / Q000138:chemical synthesis*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis*
D001463:Barbiturates; D013141:Spiro Compounds; C032232:barbituric acid