title: Meta-analysis: the influence of pre-treatment with a proton pump inhibitor on Helicobacter pylori eradication.
abstract: BACKGROUND
  There is much debate about the influence of pre-treatment with a proton pump inhibitor on Helicobacter pylori eradication. The few studies investigating the influence of pre-treatment on triple and quadruple therapies did not find differences in eradication rates. However, the high eradication rates make it difficult to study factors associated with therapy failure in small populations. In order to overcome this problem we performed a meta-analysis.
  
  
  METHODS
  The literature was searched in order to identify randomized clinical trials comparing modern triple/quadruple therapies for H. pylori eradication without pre-treatment with a proton pump inhibitor with exactly the same regimen with pre-treatment. The overall risk difference (with - without pre-treatment) was calculated by pooling the risk differences of the individual studies weighted by the inverse of their variances.
  
  
  RESULTS
  Nine studies, investigating a total of 773 patients, were identified. There was considerable variation regarding therapy regimen and duration. Pooled eradication rates were 81.3% (312 of 384) for patients with pre-treatment and 81.2% (316 of 389) for patients without pre-treatment. The (weighted) overall risk difference was 0.1% (95% CI: -5%; 5%).
  
  
  CONCLUSIONS
  Pre-treatment with a proton pump inhibitor does not influence H. pylori eradication.
authors.affiliation: Department of Gastroenterology & Hepatology, University Medical Centre St. Radboud, Nijmegen, The Netherlands. m.janssen@mdl.umcn.nl
authors.forename: M J R
authors.initials: MJ
authors.lastname: Janssen
authors.forename: R J F
authors.initials: RJ
authors.lastname: Laheij
authors.forename: W A
authors.initials: WA
authors.lastname: de Boer
authors.forename: J B M J
authors.initials: JB
authors.lastname: Jansen
mesh_terms: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D054328:Proton Pump Inhibitors; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors