Pachyelasides A-D, novel molluscicidal triterpene saponins from Pachyelasma tessmannii.
This is the first report for secondary metabolites in an African medicinal plant, Pachyelasma tessmannii (Leguminosae). Four novel saponins, pachyelasides A-D, were isolated from the methanol extract of the root bark by using recycling HPLC. These compounds showed molluscicidal activity (LD(50) < or =8.0 mug/mL) against the South American snail, Biomphalaria glabratus. The structures were determined on the basis of extensive nuclear magnetic resonance spectroscopic and matrix-assisted laser desorption/ionization time-of-flight mass spectrometric studies.
Nihei
Ken-ichi
K
Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, USA.
Ying
Bai-Ping
BP
Murakami
Takanori
T
Matsuda
Hiroko
H
Hashimoto
Masaru
M
Kubo
Isao
I
D000818:Animals; D001700:Biomphalaria / Q000187:drug effects*; D007887:Fabaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C497775:pachyelaside A; C497774:pachyelaside B; C497776:pachyelaside C; C497777:pachyelaside D