Intravascular ultrasound assessment of lesions with target vessel failure after sirolimus-eluting stent implantation.
Intravascular ultrasound (IVUS) evaluation was performed in 33 lesions with sirolimus-eluting stent (SES) failure: 4 thromboses, 26 in-stent restenoses (including 6 edge stenoses), 4 new stenoses >5 mm proximal to the stent, and 1 patient with no evidence of the implanted SES (presumably because of embolization). A minimum stent area <5.0 mm(2) (stent underexpansion) was observed in 67% of all SES failures (in particular, 67% of intrastent restenosis); negative remodeling was observed in 4 of 6 stent edge restenoses, and new lesions were secondary to an increase in plaque area.
Takebayashi
Hideo
H
Cardiovascular Research Foundation, New York, New York, USA.
Kobayashi
Yoshio
Y
Mintz
Gary S
GS
Carlier
Stéphane G
SG
Fujii
Kenichi
K
Yasuda
Takenori
T
Moussa
Issam
I
Mehran
Roxana
R
Dangas
George D
GD
Collins
Michael B
MB
Kreps
Edward
E
Lansky
Alexandra J
AJ
Stone
Gregg W
GW
Leon
Martin B
MB
Moses
Jeffrey W
JW
D023903:Coronary Restenosis / Q000000981:diagnostic imaging*; D003328:Coronary Thrombosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents / Q000009:adverse effects*; D017211:Treatment Failure; D018084:Ultrasonography, Interventional
D010975:Platelet Aggregation Inhibitors; D020123:Sirolimus