Interaction of uropathogenic Escherichia coli with host uroepithelium.
Investigation into the pathogenesis of Escherichia coli urinary tract infection has provided numerous insights into the mechanisms by which bacteria adhere, grow and persist in association with host tissue. Many molecular details concerning the interaction of these bacteria with their host have been elucidated, and the murine model of cystitis has generated a new paradigm by which acute and recurrent urinary tract infections may proceed. These advances could potentially result in the development of novel vaccines and therapies for this very costly disease.
Kau
Andrew L
AL
Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8230, Saint Louis, MO 63110-1093, USA.
Hunstad
David A
DA
Hultgren
Scott J
SJ
D000818:Animals; D004848:Epithelium / Q000276:immunology / Q000382:microbiology*; D004926:Escherichia coli / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D051379:Mice; D001743:Urinary Bladder / Q000276:immunology / Q000382:microbiology*; D014552:Urinary Tract Infections / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology*; D014774:Virulence