title: Metal carbene-promoted sequential transformations for the enantioselective synthesis of highly functionalized cycloheptadienes.
abstract: A two-step, three-component coupling of an alkyne, enol ether, and vinyl diazoester was accomplished by use of successive metal carbene-catalyzed transformations. This efficient approach to cycloheptadienes is both diastereo- and enantioselective. Kinetic resolution was accomplished on dienol ethers bearing a racemic chiral center at the propargylic position. A model is offered which explains the observed selectivity and accounts for the reactivity difference between trans- and cis-dienol ethers.
authors.affiliation: Department of Chemistry, University at Buffalo, the State University of New York, Buffalo, NY 14260-3000, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Deng
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Giessert
authors.forename: Oksana O
authors.initials: OO
authors.lastname: Gerlitz
authors.forename: Xing
authors.initials: X
authors.lastname: Dai
authors.forename: Steven T
authors.initials: ST
authors.lastname: Diver
authors.forename: Huw M L
authors.initials: HM
authors.lastname: Davies