New four-component Ugi-type reaction. Synthesis of heterocyclic structures containing a pyrrolo[1,2-a][1,4]diazepine fragment.
[reaction: see text] We present a convenient synthesis of novel heterocyclic structures containing pyrrolo[1,2-a][1,4]diazepine fragment using a novel modification of four-component Ugi condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds and discuss the scope and limitations of the chemistry involved.
Ilyn
Alexey P
AP
ChemDiv, Inc., 11558 Sorrento Valley Rd., Suite 5, San Diego, California 92121, USA.
Trifilenkov
Andrey S
AS
Kuzovkova
Julia A
JA
Kutepov
Sergey A
SA
Nikitin
Alexandre V
AV
Ivachtchenko
Alexandre V
AV
D000970:Antineoplastic Agents / Q000737:chemistry; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
D000970:Antineoplastic Agents; D001569:Benzodiazepines