title: Living donor liver transplant for malignancy.
abstract: Adult-to-adult living donor liver transplantation (ALDLT) is being increasingly utilized to treat patients with locally advanced hepatocellular carcinoma and cholangiocarcinoma who are not prioritized under the MELD allocation system. A single institution retrospective chart review examined ALDLTs performed for malignancy to identify indications, complications, and transplant outcome. Since 1997, 18 ALDLTs have been performed for malignancy as the primary indication. Thirteen patients were transplanted for HCC. The median survival following transplant was 18.6 months and four patients developed recurrent HCC. Five patients were transplanted for cholangiocarcinoma, with a 100% recurrence free survival at a mean follow up of 18 months among patients given neo-adjuvant chemoradiation. ALDLT can be safely performed for malignancy with an acceptable peri-operative mortality rate. However, HCC patients with large tumors experience a high rate of recurrence. The use of ALDLT for cholangiocarcinoma appears promising specifically in the context of neo-adjuvant therapy.
authors.affiliation: Division of Transplant Surgery, Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
authors.forename: David
authors.initials: D
authors.lastname: Axelrod
authors.forename: Alan
authors.initials: A
authors.lastname: Koffron
authors.forename: Laura
authors.initials: L
authors.lastname: Kulik
authors.forename: Patrice
authors.initials: P
authors.lastname: Al-Saden
authors.forename: Mary
authors.initials: M
authors.lastname: Mulcahy
authors.forename: Talia
authors.initials: T
authors.lastname: Baker
authors.forename: Jonathan
authors.initials: J
authors.lastname: Fryer
authors.forename: Michael
authors.initials: M
authors.lastname: Abecassis
mesh_terms: D000328:Adult; D002760:Cholangiopancreatography, Endoscopic Retrograde; D005260:Female; D005500:Follow-Up Studies; D006526:Hepatitis C / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality / Q000502:physiology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome