title: Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages.
abstract: OBJECTIVE
  To determine the aneuploidy rate in embryos of women with idiopathic recurrent miscarriages and to evaluate whether preimplantation genetic diagnosis for aneuploidy screening could be a feasible approach to improve the possibility of successful pregnancy in these couples.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Tertiary university referral center.
  
  
  METHODS
  Women (n = 49) with recurrent idiopathic miscarriages.
  
  
  METHODS
  In vitro fertilization with preimplantation genetic diagnosis for aneuploidy screening.
  
  
  METHODS
  Ongoing pregnancy rate (PR) and aneuploidy rate.
  
  
  RESULTS
  The aneuploidy rate was, respectively, 43.85% and 66.95% in the younger and older group. The ongoing PR per cycle was 25.71% in the younger and 2.94% in the older patients.
  
  
  CONCLUSIONS
  There is no therapeutic evidence to prescribe IVF with or without preimplantation genetic diagnosis for aneuploidy screening for this heterogeneous group of patients.
authors.affiliation: Center for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel), Brussels, Belgium. peter.platteau@az.vub.ac.be
authors.forename: Peter
authors.initials: P
authors.lastname: Platteau
authors.forename: Catherine
authors.initials: C
authors.lastname: Staessen
authors.forename: An
authors.initials: A
authors.lastname: Michiels
authors.forename: Andre
authors.initials: A
authors.lastname: Van Steirteghem
authors.forename: Inge
authors.initials: I
authors.lastname: Liebaers
authors.forename: Paul
authors.initials: P
authors.lastname: Devroey
mesh_terms: D000026:Abortion, Habitual / Q000175:diagnosis* / Q000235:genetics*; D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations; D005260:Female; D005820:Genetic Testing; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011247:Pregnancy; D011256:Pregnancy Outcome; D019836:Preimplantation Diagnosis; D011446:Prospective Studies