title: Effects of transcutaneous electrical nerve stimulation (TENS) on memory in elderly with mild cognitive impairment.
abstract: In previous studies, transcutaneous electrical nerve stimulation (TENS) was shown to have a positive effect on memory in Alzheimer's disease (AD) patients. Moreover, the reported effects appeared to be more beneficial in early stages of Alzheimer's disease compared to later stage intervention. Based on this stage-dependency, the present study examined the effects of TENS on memory in a preclinical stage of AD, i.e. in subjects with mild cognitive impairment (MCI). Our results suggest that TENS did not improve memory in a MCI population. Mechanisms that might underlie the absence of positive effects of the TENS treatment in a MCI population are discussed.
authors.affiliation: Department of Clinical Neuropsychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands. mw.luijpen@psy.vu.nl
authors.forename: Marijn W
authors.initials: MW
authors.lastname: Luijpen
authors.forename: Dick F
authors.initials: DF
authors.lastname: Swaab
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Sergeant
authors.forename: Koene R A
authors.initials: KR
authors.lastname: van Dijk
authors.forename: Erik J A
authors.initials: EJ
authors.lastname: Scherder
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000523:psychology / Q000628:therapy; D003072:Cognition Disorders / Q000523:psychology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D004561:Transcutaneous Electric Nerve Stimulation; D014705:Verbal Behavior / Q000502:physiology; D014706:Verbal Learning / Q000502:physiology; D014796:Visual Perception / Q000502:physiology