[Experimental research of effect of crude and processed Herba Siegesbeckiae on anti-inflammation and anti-rheumatism].
OBJECTIVE
To find out the specialities of the effect of crude and processed Herba Siegesbeckiae on anti-inflammation and anti-rheumatism.


METHODS
Experiments were made on rats with swelling foot induced by carrageenin; experiments were made on mice with swelling ear induced by xylol; experiments were made on rats with chronic granuloma; experiments were made on rats with adjuvant arthritis.


RESULTS
Foot swelling induced by carrageenin could be diminished with crude and processed Herba Siegesbeckiae at 6.0, 2.0 g x kg(-1). The rate of inhibition of foot swelling was more than 40%, effect of the crude drug was better than that of the processed one; both of them at 6.0, 2.0 g x kg(-1) could protect rats from primary and continuous lesion of adjuvant arthritis. The effect of the processed herb was obviously better than that of the crude one in its starting minute, strength and sustaining time.


CONCLUSIONS
The processed Herba Siegesbeckiae has obvious inhibition effect on immune inflammation. It is better than the crude Herb. Both of them have obvious inhibition effect on inflammation caused by carrageenin, with no distinct difference.
Hu
Hui-hua
HH
College of Chinese Medicine, Beijing University of Traditional Chinese Medicine, Beijing 100102, China. shuihh@263.net
Tang
Lu-xia
LX
Li
Xiao-meng
XM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy*; D019659:Asteraceae / Q000737:chemistry; D002351:Carrageenan; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005534:Foot Diseases / Q000139:chemically induced / Q000188:drug therapy*; D006358:Hot Temperature; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D035261:Plant Components, Aerial / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D004365:Drugs, Chinese Herbal; D002351:Carrageenan