title: NIH pre-clinical screening program: overview and current status.
abstract: The increase in the number of cases of Mycobacterium tuberculosis around the world has lead to a greater need for a more efficacious vaccine than the currently used M. bovis BCG. Despite the relative success of this attenuated vaccine there are multiple examples where alternative strategies are desperately needed. In 1996, the National Institutes of Health published a request calling for applications to test newly developed vaccines against tuberculosis. The current screening program at Colorado State University has tested a wide range of novel vaccine candidates.
authors.affiliation: Department of Microbiology, Colorado State University, Immunology and Pathology, Mycobacterial Research Laboratories, 1682 Campus Delivery, Fort Collins 80523-1682, USA. angelo.izzo@colostate.edu
authors.forename: Angelo
authors.initials: A
authors.lastname: Izzo
authors.forename: Lise
authors.initials: L
authors.lastname: Brandt
authors.forename: Todd
authors.initials: T
authors.lastname: Lasco
authors.forename: Anna-Paula
authors.initials: AP
authors.lastname: Kipnis
authors.forename: Ian
authors.initials: I
authors.lastname: Orme
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D009316:National Institutes of Health (U.S.); D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*; D032581:Tuberculosis Vaccines / Q000627:therapeutic use*; D014481:United States; D014613:Vaccines, Attenuated / Q000627:therapeutic use; D019444:Vaccines, DNA / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D032581:Tuberculosis Vaccines; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA