title: Aspochalamins A-D and aspochalasin Z produced by the endosymbiotic Fungus aspergillus niveus LU 9575. I. Taxonomy, fermentation, isolation and biological activities.
abstract: Aspochalamins A-D, a family of new cytochalasan antibiotics have been isolated from Aspergillus niveus, an endosymbiotic fungus isolated from the gut of a woodlouse belonging to the family Trichoniscidae. Besides aspochalamins, aspochalasin Z, a new member of the aspochalasin family, as well as the known mycotoxins aspochalasin D and citreoviridins A/C and B were isolated from the mycelium. Aspochalamins showed cytostatic effects towards various tumor cell lines and a weak antibacterial activity against Gram-positive bacteria.
authors.affiliation: Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Gebhardt
authors.forename: Judith
authors.initials: J
authors.lastname: Schimana
authors.forename: Alexandra
authors.initials: A
authors.lastname: Höltzel
authors.forename: Konrad
authors.initials: K
authors.lastname: Dettner
authors.forename: Siegfried
authors.initials: S
authors.lastname: Draeger
authors.forename: Winfried
authors.initials: W
authors.lastname: Beil
authors.forename: Joachim
authors.initials: J
authors.lastname: Rheinheimer
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D001230:Aspergillus / Q000145:classification / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003572:Cytochalasins / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003572:Cytochalasins; C497074:aspochalamin A; C497077:aspochalamin B; C497076:aspochalamin C; C497075:aspochalamin D