[Influence of cardiopulmonary bypass on cognitive functions in patients with ischemic heart disease].
Forty patients with ischemic heart disease subjected to coronary artery bypass graft surgery (CABGS) have been studied in conditions of cardiopulmonary bypass. All the patients underwent neuropsychological testing and enzyme immunoassay of chemokines (IL-8, IP-10, MCP-1, MCP-3, MIP-1, SDF-1alpha) and cytokines (TNF-alpha and IL-10). The study aimed at evaluation of the presence and severity of cognitive deficit developing after the surgery in conditions of cardiopulmonary bypass as well as of intrasurgery effect of tracilol on its expression. On day 9 after CABGS, there was an impairment of attention, audio-speech and memory and dynamic praxis. Tracilol exerted a pronounced neuroprotective action by inhibiting systemic inflammation response. Patients on intrasurgery treatment with tracilol did not demonstrate clinically significant cognitive deficit in the early postoperative period.
Buziashvili
Iu I
IuI
Ambat'ello
S G
SG
Aleksakhina
Iu A
IuA
Pashchenkov
M V
MV
D007611:Aprotinin / Q000627:therapeutic use; D002315:Cardiopulmonary Bypass / Q000379:methods*; D018925:Chemokines / Q000276:immunology; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000276:immunology / Q000601:surgery*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D009483:Neuropsychological Tests; D012720:Severity of Illness Index
D018925:Chemokines; D016207:Cytokines; D018696:Neuroprotective Agents; D007611:Aprotinin