E2F and signal transduction pathways.
The E2F family of transcription factors is most well known for its ability to regulate the expression of genes required for DNA replication and cell cycle progression. However, recent studies indicate that E2F can also regulate transcription of upstream components of signal transduction pathways. Here we discuss the effects of E2F activity on signal transduction pathways and its potential biological consequences.
Chaussepied
Marie
M
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.
Ginsberg
Doron
D
D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins; D004261:DNA Replication; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors / Q000502:physiology*; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors