title: Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists.
abstract: A series of isoxazole carboxamide derivatives has been developed as potent ghrelin receptor antagonists. The synthesis and structure-activity relationship (SAR) are described.
authors.affiliation: Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. zhili.xin@abbott.com
authors.forename: Zhili
authors.initials: Z
authors.lastname: Xin
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhao
authors.forename: Michael D
authors.initials: MD
authors.lastname: Serby
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Verlyn G
authors.initials: VG
authors.lastname: Schaefer
authors.forename: Douglas H
authors.initials: DH
authors.lastname: Falls
authors.forename: Wiweka
authors.initials: W
authors.lastname: Kaszubska
authors.forename: Christine A
authors.initials: CA
authors.lastname: Colins
authors.forename: Hing L
authors.initials: HL
authors.lastname: Sham
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001682:Biological Availability; D006801:Humans; D020128:Inhibitory Concentration 50; D007555:Isoxazoles / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors*; D054440:Receptors, Ghrelin; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D007555:Isoxazoles; D043562:Receptors, G-Protein-Coupled; D054440:Receptors, Ghrelin