title: Silica coatings on clarithromycin.
abstract: Pre-crystallized clarithromycin (6-O-methylerythromycin A) particles were coated with silica from the tetraethyl orthosilicate (TEOS)-ethanol-aqueous ammonia system. The coatings had a typical thickness of 100-150 nm and presented about 15 wt.% of the silica-drug composite material. The properties of the coatings depended on reactant concentration, temperature and mixing rate and, in particular, on the presence of a cationic surfactant (cetylpyridinium chloride). In the presence of cetylpyridinium chloride the silica coatings slightly decreased the rate of pure clarithromycin dissolution.
authors.affiliation: National Institute of Chemistry Slovenia, Hajdrihova 19, 1000 Ljubljana, Slovenia. marjan.bele@ki.si
authors.forename: Marjan
authors.initials: M
authors.lastname: Bele
authors.forename: Dorde
authors.initials: D
authors.lastname: Dmitrasinovic
authors.forename: Odon
authors.initials: O
authors.lastname: Planinsek
authors.forename: Mateja
authors.initials: M
authors.lastname: Salobir
authors.forename: Stane
authors.initials: S
authors.lastname: Srcic
authors.forename: Miran
authors.initials: M
authors.lastname: Gaberscek
authors.forename: Janko
authors.initials: J
authors.lastname: Jamnik
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics; D002594:Cetylpyridinium / Q000737:chemistry / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods; D017291:Clarithromycin / Q000737:chemistry / Q000493:pharmacokinetics*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003460:Crystallization; D008855:Microscopy, Electron, Scanning / Q000379:methods; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D012822:Silicon Dioxide; D002594:Cetylpyridinium; D017291:Clarithromycin