Paracentric inversion of chromosome 7(q22-31) associated with nonobstructive azoospermia.
OBJECTIVE
To examine an unusual paracentric inversion of chromosome 7 found in an azoospermic man.


METHODS
Case report.


METHODS
Infertility clinic at a private hospital.


METHODS
An azoospermic but otherwise apparently healthy man.


METHODS
Karyotyping with peripheral blood lymphocytes, microdissection testicular sperm extraction (TESE), and intracytoplasmic sperm injection (ICSI).


METHODS
Sperm count and GBG banding.


RESULTS
A karyogram revealed paracentric inversion of chromosome 7 with breakpoints at 7q22 and 7q31. Testicular histopathology confirmed the Sertoli cell-only syndrome. Successful pregnancy and delivery were achieved with microdissection TESE and ICSI.


CONCLUSIONS
Paracentric inversion of chromosome 7(q22-31) associated with nonobstructive azoospermia is rare. Chromosome 7q22-31 may be responsible for impaired spermatogenesis.
Ichioka
Kentaro
K
Department of Urology, Kurashiki Central Hospital, Okayama, Japan. ki7528@kchnet.or.jp
Yoshimura
Koji
K
Honda
Tetsuro
T
Takahashi
Akira
A
Terai
Akito
A
D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*