Variability in noise-driven integrator neurons.
Neural variability in the presence of noise has been studied mainly in resonator neurons, such as Hodgkin-Huxley or FitzHugh-Nagumo models. Here we investigate this variability for integrator neurons, whose excitability is due to a saddle-node bifurcation of the rest state instead of a Hopf bifurcation. Using simple theoretical expressions for the interspike times distributions, we obtain coefficients of variation in good agreement with numerical calculations in realistic neuron models. The main features of this coefficient as a function of noise depend on the refractory period and on the presence of bistability. The bistability is responsible for the existence of two different time scales in the spiking behavior giving an antiresonance effect.
Guantes
R
R
Instituto de Matemáticas y Física Fundamental, Consejo Superior de Investigaciones Científicas, Serrano, 123, 28006 Madrid, Spain. rgn@imaff.cfmac.csic.es
de Polavieja
Gonzalo G
GG
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D008959:Models, Neurological; D015233:Models, Statistical; D012032:Refractory Period, Electrophysiological / Q000502:physiology*; D013269:Stochastic Processes; D009435:Synaptic Transmission / Q000502:physiology*