title: Pathological correlates of poststroke depression in elderly patients.
abstract: OBJECTIVE
  The authors examined the relationship between poststroke depression and location of stroke.
  
  
  METHODS
  They performed a clinicopathological analysis of 95 consecutively autopsied elderly initial-stroke survivors.
  
  
  RESULTS
  The severity of brain vessel arteriosclerosis and frequency of brain vascular lesions were not significantly different between 21 cases with poststroke depression and 74 cases without. Earlier death was the only variable significantly associated with poststroke depression. No lesion pattern characterized the depression group.
  
  
  CONCLUSIONS
  Neuropathological data confirm that depression is associated with worse prognosis in elderly stroke patients and lend support to the hypothesis that psychological rather than neurological factors are the main determinants of poststroke depression.
authors.affiliation: Department of Psychiatry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. vpbozikas@oneway.gr
authors.forename: Vasilis P
authors.initials: VP
authors.lastname: Bozikas
authors.forename: Gabriel
authors.initials: G
authors.lastname: Gold
authors.forename: Enikö
authors.initials: E
authors.lastname: Kövari
authors.forename: Francois
authors.initials: F
authors.lastname: Herrmann
authors.forename: Athanasios
authors.initials: A
authors.lastname: Karavatos
authors.forename: Panteleimon
authors.initials: P
authors.lastname: Giannakopoulos
authors.forename: Constantin
authors.initials: C
authors.lastname: Bouras
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply* / Q000473:pathology*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000209:etiology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D020521:Stroke / Q000523:psychology*