Effect of tacrolimus in a patient with pure red-cell aplasia.
A 78-year-old woman has suffered from pure red-cell aplasia (PRCA) associated with generalized myasthenia gravis and thymoma. Cyclosporin A (CyA) with corticosteroid increased numbers of erythroid cells in her bone marrow cells but she required monthly blood transfusions. Administration of tacrolimus as a substitution for CyA inhibited progression of anemia without the need for further blood transfusion. No serious side effects were observed. This case demonstrates that tacrolimus is another option of treatment for PRCA in patients who fail to respond to CyA.
Yoshida
S
S
Department of Neurology, Utano National Hospital, Narutaki, Kyoto, Japan.
Konishi
T
T
Nishizawa
T
T
Yoshida
Y
Y
D000368:Aged; D000740:Anemia / Q000188:drug therapy / Q000209:etiology / Q000628:therapy; D016572:Cyclosporine / Q000627:therapeutic use*; D018450:Disease Progression; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D009157:Myasthenia Gravis / Q000150:complications; D012010:Red-Cell Aplasia, Pure / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012074:Remission Induction; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use*; D013945:Thymoma / Q000150:complications
D016572:Cyclosporine; D016559:Tacrolimus