Wnt signaling in disease and in development.
The highly conserved Wnt secreted proteins are critical mediators of cell-to-cell signaling during development of animals. Recent biochemical and genetic analyses have led to significant insight into understanding how Wnt signals work. The catalogue of Wnt signaling components has exploded. We now realize that multiple extracellular, cytoplasmic, and nuclear components modulate Wnt signaling. Moreover, receptor-ligand specificity and multiple feedback loops determine Wnt signaling outputs. It is also clear that Wnt signals are required for adult tissue maintenance. Perturbations in Wnt signaling cause human degenerative diseases as well as cancer.
Nusse
Roel
R
Department of Developmental Biology, Howard Hughes Medical Institute Beckman Center, School of Medicine, Stanford University, Stanford , CA, USA. rnusse@cmgm.stanford.edu
D000818:Animals; D002450:Cell Communication; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism* / Q000502:physiology*; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D010641:Phenotype; D015398:Signal Transduction; D051153:Wnt Proteins
D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins