[Expectation for Whole PTH assay in the dialysis field].
In uremic plasma, it was proven that not only 1-84 PTH but a large C fragment PTH (probably 7-84 PTH) existed considerably and Intact PTH assay measured both PTH molecules. Whole PTH was developed to measure 1-84 PTH exclusively. From our study of the iliac bone biopsy, Whole PTH and Whole PTH/7-84PTH ratio were superior indicator to Intact PTH in diagnosis of adynamic bone disease. Although there is possibility of induction of adynamic bone disease in vitamin D treatment, Whole PTH will serve as a useful monitoring method in order to prevent such risk.
Tokumoto
Akihide
A
Division of Nephrology, San-in Rosai Hospital.
D015415:Biomarkers / Q000097:blood*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000175:diagnosis*; D006801:Humans; D010281:Parathyroid Hormone / Q000097:blood*
D015415:Biomarkers; D010281:Parathyroid Hormone