Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p.
OBJECTIVE
To perform a meta-analysis of genome-wide linkage scans using body mass index (BMI) to identify genetic loci predisposing to obesity.


METHODS
A total of 13 published genome scans on obesity have used BMI as their primary end point. Five of these 13 groups agreed to provide detailed results from their scans that were required for a meta-analysis. Collectively, these five studies included a total of 2814 individuals from 505 families.


METHODS
The results of the five studies were analysed using the GSMA (genome scans meta-analysis) method.


RESULTS
The analysis revealed significant evidence for linkage of the quantitative phenotype BMI to 8p (P<0.0005).
Johnson
L
L
Mathematical Modelling and Genetic Epidemiology, Division of Genomic Medicine, University of Sheffield, UK.
Luke
A
A
Adeyemo
A
A
Deng
H-W
HW
Mitchell
B D
BD
Comuzzie
A G
AG
Cole
S A
SA
Blangero
J
J
Perola
M
M
Teare
M Dawn
MD
D000328:Adult; D015992:Body Mass Index; D002898:Chromosomes, Human, Pair 8; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D023281:Genomics; D006801:Humans; D008126:Lod Score; D008297:Male; D009765:Obesity / Q000235:genetics*