[Antifibrillatory effect of antiarrhythmic drugs of various classes under conditions of activation of the parasympathetic nervous system].
The experiments on anesthetized rats under the conditions of a 7-min occlusion of the anterior descending branch of the left coronary artery followed by reperfusion showed that drugs belonging to various classes of antiarrhythmic agents (ethacizine, IC; cardiocyclide, III; verapamil, IV; bradizol, V) produce a pronounced antifibrillatory and antiarrhythmic effects. The cholinomimetic carbacholine produced practically the same effect. Cardiocyclide, verapamil, and bradizol retained their antifibrillatory properties upon combined administration with carbacholine, while the effect of ethacizine administered jointly with carbacholine was decreased.
Kaverina
N V
NV
Chichkanov
G G
GG
Tsorin
I B
IB
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D010275:Parasympathetic Nervous System; D051381:Rats
D000889:Anti-Arrhythmia Agents