The dynamic properties of an intramolecular transition from DNA duplex to cytosine-thymine motif triplex.
We here report that the formation and breakdown of an intramolecular cytosine-thymine (CT) motif DNA triple-helix can be performed repeatedly, quickly and independently of its local concentration without performance reduction over successive cycles; as a consequence, we propose that this set of characteristics makes the DNA duplex-triplex transition an ideal candidate to power simple nanometer-scale devices capable of maintaining effective performance regardless of their local concentration.
Brucale
Marco
M
Department of Biochemistry G. Moruzzi and National Institute for the Physics of the Matter, University of Bologna, Via Irnerio 48, Bologna 40126.
Zuccheri
Giampaolo
G
Samorì
Bruno
B
D020029:Base Pairing; D002942:Circular Dichroism; D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D015394:Molecular Structure; D036103:Nanotechnology / Q000379:methods; D009690:Nucleic Acid Conformation; D013941:Thymine / Q000737:chemistry*
C051802:triplex DNA; D003596:Cytosine; D004247:DNA; D013941:Thymine