title: [The role of atrial pressure in spontaneous initiation of atrial fibrillation in the dog.].
abstract: Atrial fibrillation (AF) frequently occurred under conditions associated with atrial dilatation (stretch) or vagal hyperactivity. To study possible role of atrial stretch in spontaneous initiation of vagal AF we compared changes of right atrial pressure (RAP) and activation patterns during AF beginning. In anesthetized open-chest dogs (n=45) AF was induced by stimulation of vagal nerves (VS) (30-60 Hz, 5-10 s train). VS resulted in sinus node arrest (4.7+/-0.7 sec) with subsequent AF initiation in 153 of 229 cases. In 41% of cases of AF initiation the first atrial wave (A(1)) was closely related to ventricular activation (V) with V-A(1) interval of 94+/-5 ms (<<ventricle-dependent>> AF). This ventricular excitation induced acute short increase of RAP from 6.6.+/-0.6 to 12.9+/-1.1 mmHg (p<0.00l). Whereas other cases of AF initiation (59%) had no relation to ventricular activation (A(1)-V interval of 1382+/-173 ms) (<<ventricle-independent>> AF). Atrial activation mapping (224 unipolar electrodes) showed that interval A(1)-A(2) of <<ventricle-dependent>> AF was significantly shorter than of <<ventricle-independent>>. These data indicate that atrial stretch induced by elevation of RAP may facilitate the induction of AF but do not play a significant role in the mechanism of spontaneous AF initiation in this animal model.
authors.affiliation: Cardiology Research Comlex; ul. Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Fedorov
authors.forename: O P
authors.initials: OP
authors.lastname: Trifonova
authors.forename: A V
authors.initials: AV
authors.lastname: Glukhov
authors.forename: G G
authors.initials: GG
authors.lastname: Beloshapko
authors.forename: A V
authors.initials: AV
authors.lastname: Iushmanova
authors.forename: L V
authors.initials: LV
authors.lastname: Rozenshtraukh
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation; D062185:Atrial Pressure; D001283:Atrioventricular Node; D002304:Cardiac Pacing, Artificial; D004285:Dogs; D006325:Heart Atria; D012849:Sinoatrial Node; D014630:Vagus Nerve