The completed suicide as interplay of genes and environment.
The review will tackle the interplay of genetic and environmental risk factors behind the completed suicide. First, individual differences in suicidal behaviour in relation to heritability are presented followed by a brief discussion of genetic methods currently used to investigate candidate genes for the completed suicide. Further along the polygenetic, multi-factorial model of genetic proneness to suicidal behaviour is presented as interplay of genes and environment. Finally, the future implications in this quickly blossoming field of research are discussed.
Balazic
J
J
Institute of Forensic Medicine, Medical Faculty, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.
Marusic
A
A
D004777:Environment; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D026901:Membrane Transport Proteins / Q000235:genetics; D008995:Monoamine Oxidase / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D044263:Receptors, Serotonin, 5-HT1 / Q000235:genetics; D044348:Receptors, Serotonin, 5-HT2 / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins; D013406:Suicide, Attempted; D014365:Tryptophan Hydroxylase / Q000235:genetics
D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D044263:Receptors, Serotonin, 5-HT1; D044348:Receptors, Serotonin, 5-HT2; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D014365:Tryptophan Hydroxylase; D008995:Monoamine Oxidase