Igf-I influence on breast cancer cell survival.
The insulin-like growth factor system has been implicated in the proliferative control of breast cancer cells. In addition to this function, IGF action can also protect cells from programmed cell death. Substantial knowledge has been gained about death effector molecules and their regulation in breast cancer. IGF receptor can influence several key cell death pathways. In this review, we will focus on the intracellular mechanisms activated by IGF-I that influence cell survival.
Van Den Berg
Carla L
CL
School of Pharmacy, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box C238, Denver, CO 80262, USA. Carla.Vandenberg@UCHSC.edu