Effect of Asteracantha longifolia Nees. against CCl4 induced liver dysfunction in rat.
Significant recovery after treatment with the whole plant slurry of A.longifolia Nees. was observed in plasma AST, ALT and cholesterol levels in CCl4 induced hepatotoxic rats. This was amply supported by electron micrographs, which indicated normalization of cytoarchitecture of mitochondria and endoplasmic reticulum. The results suggest that the slurry of the plant is useful as a liver tonic.
Shailajan
Sunita
S
SP Mandali's, Ramnarain Ruia College, Matunga, Mumbai 400 019, India. sunitashailajan@yahoo.co.in
Chandra
Naresh
N
Sane
R T
RT
Menon
Sasikumar
S
D027901:Acanthaceae / Q000737:chemistry*; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control*; D008111:Liver Function Tests; D008297:Male; D008854:Microscopy, Electron; D010936:Plant Extracts / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D012838:Silymarin / Q000627:therapeutic use
D010936:Plant Extracts; D020011:Protective Agents; D012838:Silymarin; D002251:Carbon Tetrachloride