title: Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination.
abstract: Kava kava extract, Passiflora extract and a combination of both extracts, administered to mice, caused a significant decrease of the amphetamine-induced hypermotility and significant prolongation of sleeping phase induced by subcutaneous injection of barbiturates. Due to a synergism of both extracts, simultaneously administered the pharmacologically registered effect in both in vivo experiments was found to be superior over the sum of the single separately administered extracts.
authors.affiliation: 1st Department of Pharmaceutical Sciences, University of Salerno, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Capasso
authors.forename: L
authors.initials: L
authors.lastname: Sorrentino
mesh_terms: D000662:Amphetamines; D000818:Animals; D001463:Barbiturates; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020901:Kava; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D029598:Passiflora; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012890:Sleep / Q000187:drug effects*
chemical_list: D000662:Amphetamines; D001463:Barbiturates; D006993:Hypnotics and Sedatives; D010936:Plant Extracts