title: Amyloid accumulation and pathogensis of Alzheimer's disease: significance of monomeric, oligomeric and fibrillar Abeta.
abstract: This chapter reviews recent findings that indicate that soluble amyloid oligomers may represent the primary pathological species in Alzheimer's and other degenerative diseases. Various amyloids share a number of common properties, including their structures and pathways for fibril formation and accumulation in disease. Recent findings suggest that toxic amyloid oligomers share a common structure, suggesting that they also share a common mechanism of pathogenesis
authors.affiliation: University of California, Irvine, Irvine, CA 92697, USA.
authors.forename: Charles C
authors.initials: CC
authors.lastname: Glabe
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances; D017510:Protein Folding
chemical_list: D016229:Amyloid beta-Peptides; D046911:Macromolecular Substances