New triple-helix DNA stabilizing agents.
Several substituted quinolin-4-amines and heteroaromatic analogs were synthesized and evaluated for interaction with triplex polydA.2polydT and duplex polydA.polydT by using UV-thermal melting experiments. Excellent triple-helix DNA ligands with high affinity toward T.A.T triplets and triple/duplex selectivity were designed through a rational approach.
Strekowski
Lucjan
L
Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. Lucjan@gsu.edu
Hojjat
Maryam
M
Wolinska
Ewa
E
Parker
Alesia N
AN
Paliakov
Ekaterina
E
Gorecki
Tadeusz
T
Tanious
Farial A
FA
Wilson
W David
WD
D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D008024:Ligands; D009690:Nucleic Acid Conformation / Q000187:drug effects; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D011089:Polydeoxyribonucleotides / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013696:Temperature
D008024:Ligands; D011089:Polydeoxyribonucleotides; D011804:Quinolines; C098037:poly(dA)(poly(dT))2; C051802:triplex DNA; D004247:DNA