The neurotoxicity of iminodipropionitrile (IDPN) is ameliorated by copper.
Iminodipropionitrile (IDPN) was given to rats on diets with normal copper levels, 5 ppm, and to rats on diets with high copper levels, 100 ppm. The former developed neurological symptoms, namely choreoathetoid head movements, circling and retropulsion, while the latter only showed vague incoordination. Since rats, raised on a copper deficient diet alone, i.e. 0.9 ppm develop the same symptoms, we assume that IDPN chelates copper. The axons of the motor nerve cells show metachromatic degeneration in the rats given IDPN on a diet with normal copper level, but not in the rats on a high copper level.
Hartmann
Henrik A
HA
Department of Pathology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA. hahartma@wisc.edu
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000473:pathology; D003300:Copper / Q000494:pharmacology* / Q000627:therapeutic use; D020258:Neurotoxicity Syndromes / Q000473:pathology / Q000517:prevention & control*; D009570:Nitriles / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009570:Nitriles; C008110:3,3'-iminodipropionitrile; D003300:Copper