title: Angioimmunoblastic lymphadenopathy with dysproteinaemia accompanied by pleural effusion.
abstract: Angioimmunoblastic lymphadenopathy with dysproteinaemia (AILD) is a rare lymphoproliferative disorder characterized by systemic lymphadenopathy, hepatosplenomegaly, loss of body weight, fever, skin eruption, and polyclonal hypergammaglobulinaemia. Occasionally, pulmonary involvement, including pleural effusion, has also been observed. Two cases of AILD accompanied by pleural effusion are reported here. When thoracentesis was performed, an exudative effusion was obtained and there was an increase in soluble interleukin-2 receptor and immunoglobulin G, A, and M in the pleural fluid. Cytologically, atypical plasma cells, and T-cell predominant lymphocytes were also present. These findings are likely to be characteristic of pleural effusions associated with AILD and may prove to be a useful marker for diagnosis.
authors.affiliation: Division of Clinical Oncology and Palliative Medicine, Wakayama Medical University, Wakayama-City, Wakayama, Japan. y-toshi@wakayama-med.ac.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yamagata
authors.forename: Yukiharu
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamagata
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Kazuto
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Minakata
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ichinose
mesh_terms: D000368:Aged; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007119:Immunoblastic Lymphadenopathy / Q000150:complications*; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D019152:Paracentesis; D010950:Plasma Cells / Q000473:pathology; D010996:Pleural Effusion / Q000150:complications* / Q000473:pathology; D015375:Receptors, Interleukin-2 / Q000097:blood; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015375:Receptors, Interleukin-2