Acute hypoxic respiratory failure as the first manifestation of systemic-onset juvenile rheumatoid arthritis in a child.
Systemic onset juvenile rheumatoid arthritis is the most common rheumatologic disorder of childhood. Pleuropulmonary manifestations are rare in children in this multiorgan disease, and are usually not severe. The diagnosis of systemic onset juvenile rheumatoid arthritis is made by exclusion, in the presence of clinical findings constellation. We present the case of an 8-year-old girl who developed acute hypoxic respiratory failure as the first manifestation of systemic onset juvenile rheumatoid arthritis, then severe respiratory relapse 16 months later. Clinical and radiological improvement were achieved at both times after high dose pulse methylprednisolone therapy.
Rochat
Isabelle
I
Pediatric Pulmonology Unit, Department of Pediatrics, University Hospital, 6 Rue Willy Donzé, 1211 Geneva, Switzerland.
Sayegh
Yasmine
Y
Gervaix
Alain
A
Rimensberger
Peter C
PC
Argiroffo
Constance Barazzone
CB
D000208:Acute Disease; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001171:Arthritis, Juvenile / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002648:Child; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D008775:Methylprednisolone / Q000008:administration & dosage; D012008:Recurrence; D012131:Respiratory Insufficiency / Q000209:etiology*
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone