Bioactive pyranoxanthones from the roots of Calophyllum blancoi.
Phytochemical investigation of the roots of Calophyllum blancoi growing in Taiwan resulted in the isolation of three new pyranoxanthones, blancoxanthone (1), acetyl blancoxanthone (2) and 3-hydroxyblancoxanthone (3), in addition to two known pyranoxanthones, pyranojacaeubin (4) and caloxanthone (5). Structural characterization of the isolated compounds was determined by spectral analyses especially 2-D NMR. Biological study of the isolated xanthones revealed that blancoxanthone (1) exhibited significant anti-coronavirus activity.
Shen
Ya-Ching
YC
Institute of Marine Resources, National Sun Yat-sen University, Taiwan. ycshen@mail.nsysu.edu.tw
Wang
Li-Tang
LT
Khalil
Ashraf Taha
AT
Chiang
Lien Chai
LC
Cheng
Pei-Wen
PW
D000107:Acetylation; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029759:Calophyllum / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D017934:Coronavirus / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000821:virology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D011714:Pyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013624:Taiwan; D010948:Viral Plaque Assay; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C500867:3-hydroxyblancoxanthone; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D011714:Pyrans; D044004:Xanthones; C500868:acetyl blancoxanthone; C500869:blancoxanthone