title: Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T.
abstract: Peptide T (ASTTTNYT) is a promising molecule to prevent the neuropsychometric symptoms of patients suffering AIDS and for the treatment of psoriasis. In order to fully prove its therapeutic benefits, efforts were put forward to design peptidomimetics of the peptide. In this direction, in a recent computational study the natural product amygdalin was identified as a prospective peptidomimetic of the peptide and later proved to exhibit a similar chemotactic profile to the peptide. However, the cyanide moiety of amygdalin provides to the molecule a toxic profile. The present study reports the synthesis of a set of amygdalin analogs lacking the cyanide group with improved chemotactic profiles.
authors.affiliation: RUBAM, Dept. de Química Organica Biologica, (IIQAB-CSIC), Jordi Girona Salgado, 18-26, E-08034 Barcelona, Spain.
authors.forename: Eyleen
authors.initials: E
authors.lastname: Araya
authors.forename: Alex
authors.initials: A
authors.lastname: Rodriguez
authors.forename: Jaime
authors.initials: J
authors.lastname: Rubio
authors.forename: Alessandro
authors.initials: A
authors.lastname: Spada
authors.forename: Jesus
authors.initials: J
authors.lastname: Joglar
authors.forename: Amadeu
authors.initials: A
authors.lastname: Llebaria
authors.forename: Carmen
authors.initials: C
authors.lastname: Lagunas
authors.forename: Andres G
authors.initials: AG
authors.lastname: Fernandez
authors.forename: Susanna
authors.initials: S
authors.lastname: Spisani
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Perez
mesh_terms: D000678:Amygdalin / Q000031:analogs & derivatives / Q000138:chemical synthesis; D002240:Carbohydrate Sequence; D004353:Drug Evaluation, Preclinical; D006801:Humans; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D015717:Peptide T / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D015717:Peptide T; D000678:Amygdalin