title: Chemosensitivity in pediatric dermatofibrosarcoma protuberans.
abstract: Dermatofibrosarcoma protuberans (DFSP) is a rare tumor of fibrohistiocytic spectrum and uncommonly presents in infancy and childhood. The standard treatment is wide-margin surgical excision, but this is difficult to achieve in large tumors and may result in unacceptable cosmetic, structural, and functional consequences. The authors describe a child with recurring DFSP who, after extensive surgery, responded to treatment with vinblastine and oral methotrexate. This is the first reported case in literature of a chemotherapeutic response in pediatric DFSP.
authors.affiliation: Department of Oncology, Birmingham Children's Hospital, Birmingham, UK. antng@blueyonder.co.uk
authors.forename: Antony
authors.initials: A
authors.lastname: Ng
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Anthony
authors.initials: A
authors.lastname: Lander
authors.forename: Richard
authors.initials: R
authors.lastname: Grundy
mesh_terms: D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D018223:Dermatofibrosarcoma / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D014747:Vinblastine; D008727:Methotrexate