title: [Helicobacter pylori and gastric cancer: relationship with histological subtype and tumor location].
abstract: BACKGROUND
  Helicobacter pylori (HP) has been implicated in the pathogenesis of gastric adenocarcinoma. Published data on HP infection and its association with both histological subtype and tumor localization are contradictory and few data are available on this topic in Spain. The aim of the present study was to evaluate the association of HP infection with histological subtype and tumor localization in a series of patients with gastric adenocarcinoma.
  
  
  METHODS
  We retrospectively reviewed all the patients diagnosed with gastric neoplasms in Hospital del Mar in Barcelona between 1995 and 2001. The histological subtype was established using Lauren's classification. Tissue samples were obtained from the surgical specimen or from endoscopic biopsies. HP infection was histologically determined through hematoxylin-eosin, Masson's trichromic, and Giemsa staining.
  
  
  RESULTS
  During the study period, 304 gastric neoplasms, 275 (90.4%) adenocarcinomas, 22 (7.2%) lymphomas, 3 (1.0%) leiomyosarcomas, 2 (0.7%) degenerated gastrointestinal stromal tumors (GIST) and 2 (0.7%) Kaposi's sarcomas were diagnosed. In patients with adenocarcinoma, the mean age at diagnosis was 69 years and most patients were male (62%). A total of 48.1% of the neoplasms were located in the gastric antrum, 23.7% in the body and 19.1% in the fundus (13.6% in the period 1994-1997 and 25.4% in the period 1998-2001, p = 0.018). Intestinal-type gastric carcinoma was observed in 56% of the patients, diffuse-type in 28% and indeterminate-type in 16%. HP infection was confirmed in 69% of the patients (68% in intestinal subtype, 69% in diffuse subtype, and 69% in indeterminate subtype, p = 0.84), and was significantly associated with distal adenocarcinomas vs. proximal adenocarcinomas (73.6% vs 48.6%, p < 0.05).
  
  
  CONCLUSIONS
  No differences were observed between the histological type of adenocarcinoma and HP infection. In the last few years, the incidence of fundic adenocarcinomas has increased. These tumors show a lower association with HP infection.
authors.affiliation: Servicio de Aparato Digestivo, Sección de Gastroenterología, Hospital del Mar, Barcelona, Spain. 92847@imas.imim.es
authors.forename: A
authors.initials: A
authors.lastname: Seoane
authors.forename: X
authors.initials: X
authors.lastname: Bessa
authors.forename: B
authors.initials: B
authors.lastname: Balleste
authors.forename: E
authors.initials: E
authors.lastname: O'Callaghan
authors.forename: A
authors.initials: A
authors.lastname: Panadès
authors.forename: F
authors.initials: F
authors.lastname: Alameda
authors.forename: S
authors.initials: S
authors.lastname: Navarro
authors.forename: M
authors.initials: M
authors.lastname: Gallén
authors.forename: M
authors.initials: M
authors.lastname: Andreu
authors.forename: F
authors.initials: F
authors.lastname: Bory
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000382:microbiology* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000145:classification / Q000382:microbiology* / Q000473:pathology