title: Redox regulation of RyR-mediated Ca2+ release in muscle and neurons.
abstract: Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca(2+)-induced Ca2+ release, whereas reducing agents have the opposite effects. We will discuss here how modifications of highly reactive cysteine residues by endogenous redox agents or cellular redox state influence RyR channel activation by Ca2+ and ATP or inhibition by Mg2+. Possible physiological and pathological implications of these results on cellular Ca2+ signaling will be addressed as well.
authors.affiliation: FONDAP Center of Molecular Studies of the Cell, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Casilla 70005, Santiago 7, Chile. chidalgo@med.uchile.cl
authors.forename: Cecilia
authors.initials: C
authors.lastname: Hidalgo
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bull
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Behrens
authors.forename: Paulina
authors.initials: P
authors.lastname: Donoso
mesh_terms: D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology; D003545:Cysteine / Q000378:metabolism / Q000502:physiology; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D010084:Oxidation-Reduction; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism* / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel; D003545:Cysteine; D002118:Calcium