title: Inappropriate secretion of antidiuretic hormone in a patient with chronic inflammatory demyelinating polyneuropathy.
abstract: A 54-year-old man suffered from a relapse of chronic inflammatory demyelinating polyneuropathy (CIDP), and developed quadriplegia and somnolence requiring mechanical ventilation for respiratory failure. Serum Na concentration remained at low levels during the clinical course, and a diagnosis of inappropriate secretion of antidiuretic hormone (SIADH) was made. The present case had not only acute aggravation of CIDP with autonomic dysfunction but also intracranial hypertension caused by increased CSF protein (maximum level, 1,315 mg/dl). It seemed likely that injury of the afferent fibers of the baroregulatory pathway or intracranial hypertension might have contributed to SIADH in this patient.
authors.affiliation: Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Taguchi
authors.forename: Shutaro
authors.initials: S
authors.lastname: Takashima
authors.forename: Etsuko
authors.initials: E
authors.lastname: Sasahara
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kato
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Orihara
authors.forename: Yukichi
authors.initials: Y
authors.lastname: Inoue
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inoue
mesh_terms: D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007177:Inappropriate ADH Syndrome / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012121:Respiration, Artificial
chemical_list: D016756:Immunoglobulins, Intravenous