The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.
Contamination of milk with drugs, pesticides and other xenotoxins can pose a major health risk to breast-fed infants and dairy consumers. Here we show that the multidrug transporter BCRP (encoded by ABCG2) is strongly induced in the mammary gland of mice, cows and humans during lactation and that it is responsible for the active secretion of clinically and toxicologically important substrates such as the dietary carcinogen PhIP, the anticancer drug topotecan and the antiulcerative cimetidine into mouse milk.
Jonker
Johan W
JW
The Netherlands Cancer Institute, Division of Experimental Therapy, Amsterdam, The Netherlands.
Merino
Gracia
G
Musters
Sandra
S
van Herwaarden
Antonius E
AE
Bolscher
Ellen
E
Wagenaar
Els
E
Mesman
Elly
E
Dale
Trevor C
TC
Schinkel
Alfred H
AH
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002273:Carcinogens / Q000378:metabolism*; D002417:Cattle; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D007774:Lactation; D008321:Mammary Glands, Animal / Q000166:cytology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008892:Milk / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; C501412:Abcg2 protein, mouse; D002273:Carcinogens; D004364:Pharmaceutical Preparations