[The role of cyclooxygenase in pain processing in CNS].
Enzyme cyclooxygenase plays an important role in many cellular processes. It is necessary for a synthesis prostaglandines, which belong to the most important mediators of inflammatory and pain processes. Many studies show an importance of this enzyme not only in periphery but in central nervous system as well. The main unsolved question is, if the cyclooxygenase-1 or cyclooxygenase-2 play the main role in synaptic transmission. In this review we try to summarise the current overview in relation to this topic.
Slíva
J
J
Jstav farmakologie, 3. lékarská fakulta, Univerzita Karlova, Praha.
Procházková
M
M
Dolezal
T
T
D000818:Animals; D002490:Central Nervous System / Q000201:enzymology / Q000502:physiology*; D006801:Humans; D010146:Pain / Q000503:physiopathology*; D010740:Phospholipases / Q000502:physiology; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
D011451:Prostaglandin-Endoperoxide Synthases; D010740:Phospholipases