title: A new bis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity.
abstract: Novel bis-andrographolide ether (1) and six known compounds andrographolide, 14-deoxy-11,12-didehydroandrographolide, andrograpanin, 14-deoxyandrographolide, (+/-)-5-hydroxy-7,8-dimethoxyflavanone, and 5-hydroxy-7,8-dimethoxyflavone have been isolated from the aerial parts of Andrographis paniculata and their structures were established by spectral data. All the isolates were tested for the anti-HIV and cytotoxic activity.
authors.affiliation: Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
authors.forename: V L Niranjan
authors.initials: VL
authors.lastname: Reddy
authors.forename: S Malla
authors.initials: SM
authors.lastname: Reddy
authors.forename: V
authors.initials: V
authors.lastname: Ravikanth
authors.forename: P
authors.initials: P
authors.lastname: Krishnaiah
authors.forename: T Venkateshwar
authors.initials: TV
authors.lastname: Goud
authors.forename: T P
authors.initials: TP
authors.lastname: Rao
authors.forename: T Siva
authors.initials: TS
authors.lastname: Ram
authors.forename: Rajesh G
authors.initials: RG
authors.lastname: Gonnade
authors.forename: Mohan
authors.initials: M
authors.lastname: Bhadbhade
authors.forename: Y
authors.initials: Y
authors.lastname: Venkateswarlu
mesh_terms: D035685:Andrographis / Q000737:chemistry*; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004987:Ethers; D047309:Flavones / Q000302:isolation & purification* / Q000494:pharmacology; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes; D004987:Ethers; D047309:Flavones; C030419:andrographolide