title: Synthesis and schistosomicidal activity of new substituted thioxo-imidazolidine compounds.
abstract: Synthesis and physico-chemical properties of 3-benzyl-5-(4-fluoro-benzylidene)-1-methyl-2-thioxo-imidazolidin-4-ones, 5-benzylidene-3-(4-nitro-benzyl)-2-thioxo-imidazolidin-4-ones and 4-acridin-9-ylmethylene-1-benzyl-5-thioxo-imidazolidin-2-ones compounds are described. These thioxo-imidazolidine derivatives were prepared by alkylation and condensation with 4-fluoro-benzaldehyde or nucleophilic Michael addition with cyanoacrylates. The schistosomicidal activity of 3-benzyl-5-(4-fluoro-benzylidene)-1-methyl-2-thioxo-imidazolidin-4-one compounds was evaluated.
authors.affiliation: Laboratorio de Imunopatologia Keizo Asami - LIKA, Centro de Ciências Biológicas, Universidade Federal de Pernambuco - UFPE, Recife, Brasil.
authors.forename: M C P A
authors.initials: MC
authors.lastname: Albuquerque
authors.forename: T G
authors.initials: TG
authors.lastname: Silva
authors.forename: M G R
authors.initials: MG
authors.lastname: Pitta
authors.forename: A C A
authors.initials: AC
authors.lastname: Silva
authors.forename: P G
authors.initials: PG
authors.lastname: Silva
authors.forename: E
authors.initials: E
authors.lastname: Malagueño
authors.forename: J V
authors.initials: JV
authors.lastname: Santana
authors.forename: A G
authors.initials: AG
authors.lastname: Wanderley
authors.forename: M C A
authors.initials: MC
authors.lastname: Lima
authors.forename: S L
authors.initials: SL
authors.lastname: Galdino
authors.forename: J
authors.initials: J
authors.lastname: Barbe
authors.forename: I R
authors.initials: IR
authors.lastname: Pitta
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D005260:Female; D048289:Imidazolidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D012550:Schistosoma mansoni / Q000187:drug effects; D012556:Schistosomicides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D048289:Imidazolidines; D007202:Indicators and Reagents; D012556:Schistosomicides