Pharmacokinetic effects of diphenhydramine or oxycodone in simulated acetaminophen overdose.
OBJECTIVE
To determine the effects of co-ingested diphenhydramine (DPH) or oxycodone (OXY) on the absorption kinetics of simulated acetaminophen (APAP) overdose.


METHODS
This was an institutional review board-approved, prospective crossover study of ten healthy human volunteers ingesting 5 grams of APAP, 5 grams of APAP + 250 mg of DPH (APAP+DPH), or 5 grams of APAP + 0.5 mg/kg of OXY (APAP+OXY). Serum APAP concentrations (APAPs) were measured hourly from zero through eight hours and again at 24 hours, and basic noncompartmental pharmacokinetic parameters were compared.


RESULTS
For APAP alone, the mean parameters were: maximum APAP concentration ([APAP](max)) 71.8 microg/mL, time to peak [APAP] (t(max)) 1.71 hours, and area under the receiver operating characteristic curve (AUC(0-8)) 318.3 microg-hr/mL. For APAP+DPH, the mean parameters were: [APAP](max) 67.6 microg/mL, t(max) 1.90 hours, and AUC(0-8) 297.7 microg-hr/mL. For APAP+OXY, the parameters were: [APAP](max) 42.9 microg/mL, t(max) 2.87 hours, and AUC(0-8) 232.1 microg-hr/mL. Compared with APAP alone, APAP+OXY had a 27% lower AUC, a 40% lower [APAP](max), and a 68% longer t(max). Co-ingested DPH had no significant effect on APAP absorption, except a 6% decrease in the AUC.


CONCLUSIONS
Co-ingested OXY, but not DPH, delayed absorption of APAP. This suggests a potential role for activated charcoal administration beyond one hour postingestion after mixed ingestions that include OXY.
Halcomb
S Eliza
SE
Division of Emergency Medicine, Washington University School of Medicine, Campus Box 8072, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Sivilotti
Marco L A
ML
Goklaney
Anil
A
Mullins
Michael E
ME
D000042:Absorption; D000082:Acetaminophen / Q000506:poisoning*; D000704:Analysis of Variance; D019540:Area Under Curve; D018592:Cross-Over Studies; D004155:Diphenhydramine / Q000493:pharmacokinetics*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008297:Male; D010098:Oxycodone / Q000493:pharmacokinetics*; D011446:Prospective Studies; D018709:Statistics, Nonparametric
D000082:Acetaminophen; D004155:Diphenhydramine; D010098:Oxycodone