[Influence of Pueraria thomsonii on insulin resistance induced by dexamethasone].
OBJECTIVE
To investigate the influence of Pueraria thomsonii on insulin resistance induced by dexamethasone.


METHODS
3T3-L1 adipocytes model of insulin resistance was made by dexamethasone and the change of glucose concentration in cell culture was determined after action of drugs. Rat animal model of insulin resistance was made by intramuscular dexamethasone (1 mg x kg(-1), every other day), and fasting blood glucose (FBG) and fasting serum insulin (FINS) were enamined, and at the end of the experiment, insulin sensitive index (ISI) and insulin resistance index (IRI) were calculated.


RESULTS
P. thomsonii decreased the concentration of glucose in 3T3-L1 adipocytes culture significantly and improved the sensitivity of 3T3-L1 adipocytes to insulin. P. thomsonii improved the sensitivity of rats to insulin and diminished the fasting serum insulin and insulin resistance index.


CONCLUSIONS
P. thomsonii can significantly improve insulin resistance induced by dexamethasone.
Bai
Hong-yan
HY
Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Zou
Wen-jun
WJ
Gao
Xiao-ping
XP
D016475:3T3 Cells; D017667:Adipocytes / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007328:Insulin; D003907:Dexamethasone; D005947:Glucose