title: Enniatin production by the entomopathogenic fungus Verticillium hemipterigenum BCC 1449.
abstract: Optimal fermentation conditions for enniatin production using the entomopathogenic fungus Verticillium hemipterigenum BCC 1449 have been investigated. Among various liquid media tested, highest efficiency of enniatin production was achieved by fermentation in yeast extract sucrose. Application of this condition to large-scale fermentation resulted in the isolation of three new analogs, O1, O2 and O3, which are closely related isomers that were characterized as an inseparable mixture, along with seven known enniatins.
authors.affiliation: National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Phaholyothin Road, Klong 1, Klong Luang, Pathumthani 12120, Thailand.
authors.forename: Sumalee
authors.initials: S
authors.lastname: Supothina
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
authors.forename: Kanyawim
authors.initials: K
authors.lastname: Kirtikara
authors.forename: Morakot
authors.initials: M
authors.lastname: Tanticharoen
authors.forename: Yodhathai
authors.initials: Y
authors.lastname: Thebtaranonth
mesh_terms: D000107:Acetylation; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D000904:Antibiotics, Antitubercular / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology; D001894:Borohydrides; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media / Q000737:chemistry; D047630:Depsipeptides / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D018020:Lithium Compounds; D009682:Magnetic Resonance Spectroscopy; D010963:Plasmodium falciparum / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D020172:Verticillium / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000904:Antibiotics, Antitubercular; D000962:Antimalarials; D001894:Borohydrides; D003470:Culture Media; D047630:Depsipeptides; D018020:Lithium Compounds; C100264:enniatins; C040936:lithium borohydride