title: The outcome of 400 consecutive liver grafts using the aortic perfusion-only technique.
abstract: The goal of this study is to establish the effect of cadaveric liver retrieval, using the technique of aortic perfusion only, on liver graft function, and to identify associated potential risk factors for graft dysfunction. The authors reviewed the outcome of 400 consecutive, orthotopic, cadaveric liver transplantation retrieved by the technique of aortic perfusion only. Relevant parameters pertaining to the donor, recipient, procurement, graft and peri-operative variables are analyzed to assess their influence on graft function. The univariant analysis revealed that donor age, body mass index, blood pressure, and vasopressor dependence influence graft function. Furthermore, predictors of dysfunction included prolonged anhepatic phase, transplantation duration and partial grafts. In addition, multivariant analysis revealed significant association between obesity of donors, partial graft, and dysfunction. The technique of aortic perfusion only, is a simple and reproducible procedure. The post-transplantation outcomes appear to be similar to those reported for the traditional liver procurement technique.
authors.affiliation: Department of General Surgery, Division of Surgery, Saint George Hospital, P.O. Box 166 378, Achrafieh, 1100 2807, Beirut, Lebanon. zer18@hotmail.com
authors.forename: Ziad
authors.initials: Z
authors.lastname: El-Rassi
authors.forename: Stephane
authors.initials: S
authors.lastname: Barcet
authors.forename: Isabelle
authors.initials: I
authors.lastname: Mechet
authors.forename: Karim
authors.initials: K
authors.lastname: Chahine
authors.forename: Pierre
authors.initials: P
authors.lastname: Bernard
authors.forename: Lionel
authors.initials: L
authors.lastname: Chane
authors.forename: Pierre
authors.initials: P
authors.lastname: Sagnard
authors.forename: Bertrand
authors.initials: B
authors.lastname: Delafasse
authors.forename: Yves
authors.initials: Y
authors.lastname: Bouffond
authors.forename: Olivier
authors.initials: O
authors.lastname: Boillot
mesh_terms: D000328:Adult; D001011:Aorta; D002102:Cadaver; D005260:Female; D006085:Graft Survival; D006801:Humans; D008107:Liver Diseases / Q000401:mortality* / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000401:mortality; D010477:Perfusion; D012307:Risk Factors; D014019:Tissue Donors / Q000706:statistics & numerical data; D009927:Tissue and Organ Procurement; D016896:Treatment Outcome