title: 1,3-dihydroxy-5-(tridec-4',7'-dienyl)benzene: a new cytotoxic compound from Lithraea molleoides.
abstract: A dichloromethane extract from the leaves of Lithraea molleoides (Anacardiaceae), an argentine medicinal plant, showed cytotoxicity on human hepatocellular carcinoma cell line. Bioassay guided fractionation of this extract led to the isolation of a new active 5-alkyl resorcinol: 1,3-dihydroxy-5-(tridec-4',7'-dienyl)benzene. Chemical structure was established based on spectroscopic data (UV, IR, MS, 1H-NMR, 13C-NMR, COSY). This compound presented cytotoxic activity on 3 human tumoral cell lines: hepatocellular carcinoma cell line-Hep G2 (IC50 +/- SD of 68 +/- 2 microM), mucoepidermoid pulmonary carcinoma cell line-H292 (IC50 +/- SD of 63 +/- 5 microM) and mammary gland adenocarcinoma cell line -MCF7 (IC50 +/- SD of 147 +/- 5).
authors.affiliation: Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956, 2 Piso, 1113 Buenos Aires, Argentina. plopez@ffyb.uba.ar
authors.forename: P
authors.initials: P
authors.lastname: López
authors.forename: M J
authors.initials: MJ
authors.lastname: Ruffa
authors.forename: L
authors.initials: L
authors.lastname: Cavallaro
authors.forename: R
authors.initials: R
authors.lastname: Campos
authors.forename: V
authors.initials: V
authors.lastname: Martino
authors.forename: G
authors.initials: G
authors.lastname: Ferraro
mesh_terms: D027926:Anacardiaceae; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D012118:Resorcinols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: C499259:1,3-dihydroxy-5-(tridec-4',7'-dienyl)benzene; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012118:Resorcinols