title: Basal cell carcinoma with matrical differentiation: a case study with analysis of beta-catenin.
abstract: Matrical differentiation in basal cell carcinoma (BCC) is rare. Only nine cases have been described that showed typical diagnostic features of BCC, in addition to shadow cells indicating hair-matrix differentiation. These cases often present a diagnostic challenge due to confusion with pilomatrixoma or pilomatrix carcinoma. We present a case of BCC with matrical differentiation in a 78-year-old man. Immunohistochemical and molecular methods are used to differentiate this lesion from benign or malignant forms of pilomatrixoma. differentiation: a case study with analysis of beta-catenin.
authors.affiliation: Department of Pathology, Division of Dermatopathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Henry D
authors.initials: HD
authors.lastname: Haskell
authors.forename: Harley A
authors.initials: HA
authors.lastname: Haynes
authors.forename: Phillip H
authors.initials: PH
authors.lastname: McKee
authors.forename: Mark
authors.initials: M
authors.lastname: Redston
authors.forename: Scott R
authors.initials: SR
authors.lastname: Granter
authors.forename: Alexander J F
authors.initials: AJ
authors.lastname: Lazar
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D003598:Cytoskeletal Proteins / Q000032:analysis*; D003937:Diagnosis, Differential; D006201:Hair Diseases / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D015580:Mohs Surgery; D018296:Pilomatrixoma / Q000175:diagnosis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D015534:Trans-Activators / Q000032:analysis*; D051176:beta Catenin
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin