title: [The role of myofibroblast in the development of pathological scar].
abstract: OBJECTIVE
  To study the effect of myofibroblast on the development of pathological scar.
  
  
  METHODS
  From 1998 to 2000, 14 cases of keloid(k), 13 cases of hypertrophic scar(HS), and 7 cases of scar were studied through immunohistochemistry and electron microscope.
  
  
  RESULTS
  Myofibroblasts were often observed in the hypertrophic HS by electron microscope, but no myofibroblast was observed in the K and NS. alpha-SM-actin was expressed in fibroblast of HS, but was not expressed in K and NS.
  
  
  CONCLUSIONS
  Myofibroblast may play a role in the development of hypertrophic scar. The difference between the absence of myofibroblast in keloid and the invasion of keloid deserves further study.
authors.affiliation: Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu Sichuan 610041, P R China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Cen
authors.forename: Tang
authors.initials: T
authors.lastname: Ying
authors.forename: Xuewen
authors.initials: X
authors.lastname: Xu
mesh_terms: D000199:Actins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D017439:Cicatrix, Hypertrophic / Q000378:metabolism / Q000473:pathology*; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007627:Keloid / Q000378:metabolism / Q000473:pathology*; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009130:Muscle, Smooth / Q000737:chemistry; D055815:Young Adult
chemical_list: D000199:Actins