The delta32 allele distribution of the CCR5 gene and its relationship with certain cancers in a Turkish population.
OBJECTIVE
In the present study, we determined the frequency of delta32 allele distribution and its relationship with various carcinomas in a Turkish population.


METHODS
We determined the allelic frequency of CCR5-delta32 in 267 healthy individuals as well as 39 breast, 34 laryngeal, 30 thyroid and 20 brain carcinomas in a Turkish population using polymerase chain reaction (PCR).


RESULTS
The frequency of mutant delta32 alleles in the Turkish population was 2.18%. The population was in the Hardy-Weinberg equilibrium. The frequency of the mutant allele was the highest in patients with breast carcinoma (3.85%) among all the carcinomas studied, but there was no statistically significant relationship (P = 0.334).


CONCLUSIONS
The frequency of the delta32 allele detected in the Turkish population was slightly lower in comparison with the previous reports. The frequency of heterozygote genotypes remained an independent risk factor for the development of breast cancer (odd ratio = 1.628; confidence intervals = 0.442-5.992) as well as other cancers examined in this study.
Degerli
Naci
N
Department of Biology, Faculty of Science and Literature, Cumhuriyet University, 58140 Sivas, Turkey. ndegerli@cumhuriyet.edu.tr
Yilmaz
Emire
E
Bardakci
Fevzi
F
D000328:Adult; D000368:Aged; D000483:Alleles; D001932:Brain Neoplasms / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000208:ethnology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000235:genetics; D014421:Turkey
D019713:Receptors, CCR5