Effect of statin therapy on risk of ventricular arrhythmia among patients with coronary artery disease and an implantable cardioverter-defibrillator.
Hydroxymethylglutaryl coenzyme-A reductase inhibitors, or statins, have been shown to decrease mortality rates in patients who have coronary artery disease. It has been postulated that part of the mortality benefit conferred by statins is due to a decrease in ventricular arrhythmias. We assessed the effect of statin therapy on recurrent ventricular arrhythmias in 281 patients who developed coronary artery disease after implantable cardioverter-defibrillator placement. Statin therapy was associated with a significant decrease in the risk of ventricular arrhythmia that would require implantable cardioverter-defibrillator therapy.
Chiu
John H
JH
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Abdelhadi
Raed H
RH
Chung
Mina K
MK
Gurm
Hitinder S
HS
Marrouche
Nassir F
NF
Saliba
Walid I
WI
Natale
Andrea
A
Martin
David O
DO
D000368:Aged; D003324:Coronary Artery Disease / Q000628:therapy*; D017147:Defibrillators, Implantable; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D055502:Secondary Prevention; D014693:Ventricular Fibrillation / Q000628:therapy*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors