title: A novel human G protein-coupled receptor is over-expressed in prostate cancer.
abstract: G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the identification of a novel GPCR that shows no significant amino acid identity to any one of the known members of the GPCR superfamily. The gene expression pattern of this receptor is restricted: in normal tissues it is confined to the nervous system and testis, but we also detected gene expression in several tumor types, most notably prostate cancer, suggesting a potential role for this gene as a marker for this disease.
authors.affiliation: Ludwig Institute for Cancer Research, Rua Professor Antonio Prudente, 109, 4th floor, São Paulo, SP, Brasil.
authors.forename: Raphael B
authors.initials: RB
authors.lastname: Parmigiani
authors.forename: Geraldo S
authors.initials: GS
authors.lastname: Magalhães
authors.forename: Pedro A F
authors.initials: PA
authors.lastname: Galante
authors.forename: Carina V B
authors.initials: CV
authors.lastname: Manzini
authors.forename: Anamaria A
authors.initials: AA
authors.lastname: Camargo
authors.forename: Bettina
authors.initials: B
authors.lastname: Malnic
mesh_terms: D000595:Amino Acid Sequence; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D010802:Phylogeny; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D043562:Receptors, G-Protein-Coupled