title: Risk-based approach to appraise valve closure in the clam Corbicula fluminea in response to waterborne metals.
abstract: We developed a risk-based approach to assess how the valve closure behavior of Asiatic clam Corbicula fluminea responds to waterborne copper (Cu) and cadmium (Cd). We reanalyzed the valve closure response data from published literature to reconstruct the response time-dependent dose-response profiles based on an empirical three-parameter Hill equation model. We integrated probabilistic exposure profiles of measured environmental Cu and Cd concentrations in the western coastal areas of Taiwan with the reconstructed dose-response relationships at different integration times of response to quantitatively estimate the valve response risk. The risk assessment results implicate exposure to waterborne Cu and Cd may pose no significant risk to clam valve activity in the short-time response periods (e.g., <30 min), yet a relative high risk for valve closure response to waterborne Cu at response times greater than 120 min is alarming. We successfully linked reconstructed dose-response profiles and EC50-time relationships associated with the fitted daily valve opening/closing rhythm characterized by a three-parameter lognormal function to predict the time-varying bivalve closure rhythm response to waterborne metals. We parameterized the proposed predictive model that should encourage a risk-management framework for discussion of future design of biological monitoring systems.
authors.affiliation: Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 10617, ROC. cmliao@ntu.edu.tw
authors.forename: Chung-Min
authors.initials: CM
authors.lastname: Liao
authors.forename: Li-John
authors.initials: LJ
authors.lastname: Jou
authors.forename: Bo-Ching
authors.initials: BC
authors.lastname: Chen
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000187:drug effects / Q000502:physiology*; D002104:Cadmium / Q000633:toxicity; D003300:Copper / Q000633:toxicity; D008670:Metals / Q000633:toxicity*; D015233:Models, Statistical; D018570:Risk Assessment; D018675:Toxicity Tests; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D008670:Metals; D014874:Water Pollutants, Chemical; D002104:Cadmium; D003300:Copper