Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance.
Many steps in the Wnt signalling pathway may be altered during the process of carcinogenesis. This Review focuses on the changes observed in gastrointestinal cancers. A literature search was undertaken and the currently available data summarised. Understanding the alterations to this signalling pathway may help to reveal future targets for therapeutic agents. In addition, since in some tumours, levels of components of the Wnt pathway have been found to correlate with clinical stage, their potential use as prognostic indicators is highlighted.
Doucas
H
H
Department of Cancer Biomarkers and Prevention Group, Biocentre, Leicester LE1 7RH, UK. hd24@leicester.ac.uk
Garcea
G
G
Neal
C P
CP
Manson
M M
MM
Berry
D P
DP
D060466:Axin Protein; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D019938:Cyclin D1 / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D051157:Frizzled Receptors; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000378:metabolism; D017491:Genes, APC; D016259:Genes, myc; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000378:metabolism; D011379:Prognosis; D011506:Proteins / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism; D051153:Wnt Proteins; D051176:beta Catenin
D060466:Axin Protein; C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D051157:Frizzled Receptors; D036341:Intercellular Signaling Peptides and Proteins; D009842:Oligopeptides; D011506:Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D051176:beta Catenin; D019938:Cyclin D1; C056289:GSK peptide; D020783:Matrix Metalloproteinase 7