title: NAC transcription factors: structurally distinct, functionally diverse.
abstract: NAC proteins constitute one of the largest families of plant-specific transcription factors, and the family is present in a wide range of land plants. Here, we summarize the biological and molecular functions of the NAC family, paying particular attention to the intricate regulation of NAC protein level and localization, and to the first indications of NAC participation in transcription factor networks. The recent determination of the DNA and protein binding NAC domain structure offers insight into the molecular functions of the protein family. Research into NAC transcription factors has demonstrated the importance of this protein family in the biology of plants and the need for further studies.
authors.affiliation: Institute of Molecular Biology, University of Copenhagen, Øster Farimagsgade 2A, DK-1353 Copenhagen K, Denmark.
authors.forename: Addie Nina
authors.initials: AN
authors.lastname: Olsen
authors.forename: Heidi A
authors.initials: HA
authors.lastname: Ernst
authors.forename: Leila Lo
authors.initials: LL
authors.lastname: Leggio
authors.forename: Karen
authors.initials: K
authors.lastname: Skriver
mesh_terms: D000595:Amino Acid Sequence; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000235:genetics; D016384:Consensus Sequence; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000378:metabolism*; D011487:Protein Conformation; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D029681:Arabidopsis Proteins; D010940:Plant Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C493659:NAC019 protein, Arabidopsis