Obstructive jaundice as a presentation of ganglioneuroblastoma.
Obstructive jaundice is a rare symptom in the neuroblastic tumor. Seven cases of obstructive jaundice caused by neuroblastoma have been reported, and only three of these patients had the symptom at the onset of the disease. The authors report a case of ganglioneuroblastoma presenting with obstructive jaundice as a rare initial feature. After the histologic diagnosis with open biopsy, chemotherapy consisting of cisplatin, pirarubicin hydrochloride/doxorubicin, cyclophosphamide, and vincristine was given. The treatment resulted in reduction in the tumor size and relief of the obstructive jaundice. Complete resection of the tumor was possible after five courses of chemotherapy.
Ito
Aya
A
Department of Pediatrics, Jichi Medical School, Kawachi-gun, Tochigi-ken, Japan.
Uno
Takeji
T
Gunji
Yuji
Y
Yamauchi
Tadahiko
T
Egami
Satoshi
S
Kawarasaki
Hideo
H
Momoi
Mariko Y
MY
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D018305:Ganglioneuroblastoma / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology*; D008297:Male; D012186:Retroperitoneal Neoplasms / Q000150:complications* / Q000188:drug therapy; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; C027260:pirarubicin; D002945:Cisplatin