[Influence of compatibility ratio of Fufang Danshen on the dissolution of Danshen compositions].
A high performance liquid chromatographic (HPLC) method has been developed using peak ratio to compare the Danshen ingredients with varying peak ratios of Danshen (Salvia miltiorrhiza Bunge.) to Sanqi (Panax Notoginseng) from 10:0 to 1:10 in Fufang Danshen which is composed of Danshen and Sanqi. The experimental results show that the contents of major components of all samples decocted together are higher than those of Danshen. The contents of Danshen major components are the highest in classic formula (the mass ratio of Danshen to Sanqi is 5:3). Therefore, Danshen decocted together with Sanqi at a ratio of 5:3 can increase the dissolution ability of Danshen ingredients. This, therefore, could constitute a solid rationale to the compatibility rule in Chinese traditional medicine with both scientific merits and intrinsic reasoning.
Zeng
Guifeng
G
Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116011, China.
Xu
Qing
Q
Xiao
Hongbin
H
Liang
Xinmiao
X
D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000032:analysis; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005894:Panax / Q000737:chemistry*; D027561:Salvia miltiorrhiza / Q000737:chemistry*
D004224:Diterpenes; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C108596:danshenol A; C108597:danshenol B