title: Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma.
abstract: BACKGROUND
  Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma (HCC-CC) have not been established.
  
  
  METHODS
  Data of patients who underwent surgical resection for HCC-CC were compared with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CC) patients.
  
  
  RESULTS
  The prevalence of hepatitis B positivity (54.0%) and that of cirrhosis (54.2%) in the HCC-CC group were of intermediate tendency between the HCC group and the CC group. The HCC-CC group presented with a higher prevalence of multiplicity and microvascular emboli and portal vein or hepatic vein invasion, but a lower prevalence of capsular formation compared with the other groups. One- and 3-year survival rates in the HCC-CC group (81.9% and 47.0%, respectively) were lower than those in the HCC group and higher than those in the CC group. The cumulative recurrence rates at 6 months and at 1 year in the HCC-CC group (25.0% and 33.3%, respectively) were higher than those in the HCC group and lower than those in the CC group.
  
  
  CONCLUSIONS
  The HCC-CC group has distinct clinicopathologic features compared with the HCC or CC groups. In addition, the HCC-CC group has a prognosis that is better than the CC group but worse than the HCC group.
authors.affiliation: Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong 50, Kangnam-ku, Seoul, Korea 135-710.
authors.forename: Kwang Cheol
authors.initials: KC
authors.lastname: Koh
authors.forename: Hyuk
authors.initials: H
authors.lastname: Lee
authors.forename: Moon Seok
authors.initials: MS
authors.lastname: Choi
authors.forename: Joon Hyoek
authors.initials: JH
authors.lastname: Lee
authors.forename: Seung Woon
authors.initials: SW
authors.lastname: Paik
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Yoo
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Rhee
authors.forename: Jae Won
authors.initials: JW
authors.lastname: Cho
authors.forename: Cheol Keun
authors.initials: CK
authors.lastname: Park
authors.forename: Hong Joo
authors.initials: HJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D001653:Bile Ducts, Intrahepatic; D006528:Carcinoma, Hepatocellular / Q000401:mortality* / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000401:mortality* / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis