title: [Expressions of Abeta1-40, Abeta1-42, tau202, tau396 and tau404 after intracerebroventricular injection of streptozotocin in rats].
abstract: OBJECTIVE
  To investigate the effects of intracerebroventricular (ICV) administration of streptozotocin (STZ) on the expressions of Abeta and hyperphosphorylation of tau protein in rat brain.
  
  
  METHODS
  Twenty-four adult SD rats were randomized into 2 groups to receive ICV of STZ bilaterally at the dose of 3 mg/kg (with the injection repeated on day 3) or normal saline injection in an identical manner. Twenty-one days later, the expressions of Abeta(1-40), Abeta(1-42), tau(202), tau(396) and tau(404) were investigated immunohistochemically.
  
  
  RESULTS
  After STZ administration, the expressions of Abeta(1-40), Abeta(1-42), tau(202), tau(396) and tau(404) increased in both the cortex and hippocampus in the rat brain.
  
  
  CONCLUSIONS
  ICV injection of STZ increases the expression of Abeta and promotes hyerphosphorylation of tau protein.
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. bzchu@yahoo.com.cn
authors.forename: Wen-Zheng
authors.initials: WZ
authors.lastname: Chu
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Qian
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D001921:Brain / Q000378:metabolism; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D013311:Streptozocin / Q000494:pharmacology*; D016875:tau Proteins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D013311:Streptozocin