title: Effectivity of laser-induced thermotherapy: in vivo comparison of arterial microembolization and complete hepatic inflow occlusion.
abstract: OBJECTIVE
  Laser-induced thermotherapy (LITT) is a promising method for local treatment of liver metastases. The aim of this study was to compare the effect of LITT on lesion size when combined with hepatic arterial microembolization or complete hepatic blood flow occlusion.
  
  
  METHODS
  In a porcine liver model, LITT (30 W 15 minutes) was performed with either normal (n = 12), partially interrupted (arterial microembolization via a hepatic artery catheter n = 12) or completely interrupted hepatic perfusion (Pringle's maneuver, n = 12). LITT lesions were macro- and microscopically assessed after liver dissection.
  
  
  RESULTS
  Hepatic inflow occlusion led to a fourfold increase in lesion volume after arterial microembolization and a ninefold increase after complete interruption (6.3. cm3 vs. 27.1 cm3 vs. 58.8 cm3, P < 0.01).
  
  
  CONCLUSIONS
  Interrupting hepatic perfusion significantly increases lesion volumes in LITT. This beneficial effect can also be achieved in the percutaneous application mode by LITT combined with arterial microembolization via a hepatic artery catheter.
authors.affiliation: Department of General, Vascular, and Thoracic Surgery, Charité University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany. joerg-peter.ritz@charite.de
authors.forename: Joerg-Peter
authors.initials: JP
authors.lastname: Ritz
authors.forename: Kai
authors.initials: K
authors.lastname: Lehmann
authors.forename: Christoph
authors.initials: C
authors.lastname: Isbert
authors.forename: Andre
authors.initials: A
authors.lastname: Roggan
authors.forename: Christoph T
authors.initials: CT
authors.lastname: Germer
authors.forename: Heinz J
authors.initials: HJ
authors.lastname: Buhr
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic / Q000379:methods*; D006499:Hepatic Artery; D053685:Laser Therapy; D008102:Liver Circulation / Q000528:radiation effects; D008113:Liver Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000628:therapy*; D008297:Male; D008863:Microspheres; D013213:Starch / Q000008:administration & dosage; D013552:Swine
chemical_list: C083286:degradable starch microspheres; D013213:Starch