title: Does dental disease hurt your heart?
abstract: Recent research has yielded conflicting data regarding the relationship between dental disease, particularly periodontitis, and cardiovascular disease. A causative relationship would have major ramifications for health care. There is a plausible theoretical basis for such a link, as increased levels of inflammatory mediators may increase the risk of atherosclerotic plaque formation. Nevertheless, a clinical confirmation of a causative relationship has been difficult, in part because cardiovascular disease and periodontal disease share common risk factors such as increasing age and tobacco use, and because cardiovascular medications may increase the risk of periodontitis. Patients should be encouraged to control documented risk factors for cardiovascular disease and to maintain oral health for its well-known health benefits.
authors.affiliation: Department of Diagnostic Sciences, School of Dentistry, University of Detroit Mercy, Detroit, Michigan 48219-0900, USA. gordonsc@udmercy.edu
authors.forename: Sara C
authors.initials: SC
authors.lastname: Gordon
authors.forename: Andrei
authors.initials: A
authors.lastname: Barasch
authors.forename: W Choong
authors.initials: WC
authors.lastname: Foong
authors.forename: Ahmed K
authors.initials: AK
authors.lastname: Elgeneidy
authors.forename: Monika M
authors.initials: MM
authors.lastname: Safford
mesh_terms: D000367:Age Factors; D002318:Cardiovascular Diseases / Q000209:etiology*; D016207:Cytokines / Q000378:metabolism; D005491:Focal Infection, Dental / Q000150:complications*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008070:Lipopolysaccharides / Q000009:adverse effects; D010518:Periodontitis / Q000150:complications*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D008070:Lipopolysaccharides