title: [Gastroesophageal reflux disease refractory to esomeprazole].
abstract: Resistance to proton pump inhibitors (PPI) in gastroesophageal reflux disease (GERD), which has been described in patients treated with omeprazole, could explain some exceptional cases of treatment failure and the need for surgery. The objective test of resistance to PPI is obtained with 24-hour intragastric pH-metry performed during treatment. A gastric pH of less than 4 for more than 50% of recording time indicates resistance. We present a patient with non-erosive GERD and treatment failure to omeprazole and proven resistance to esomeprazole which, to our knowledge, has only been reported in patients with Barrett's esophagus.
authors.affiliation: Servicio de Medicina Digestiva, Hospital Universitari La Fe, Valencia, Spain. manueljosev@hotmail.com
authors.forename: M J
authors.initials: MJ
authors.lastname: Velasco
authors.forename: V
authors.initials: V
authors.lastname: Ortiz
authors.forename: J
authors.initials: J
authors.lastname: Ponce
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D064098:Esomeprazole; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use*; D054328:Proton Pump Inhibitors; D017211:Treatment Failure
chemical_list: D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D009853:Omeprazole; D064098:Esomeprazole