title: Changes in autonomic nervous activity after catheter ablation of atrial tachycardia arising from the atrioventricular annulus.
abstract: Radiofrequency (RF) catheter ablation of supraventricular tachycardias causes local parasympathetic denervation. This study used heart rate variability (HRV) to evaluate the effects of ablation of atrial tachycardia (AT) arising from the atrioventricular annulus (AVAT) on autonomic function. Ten patients with AVAT were referred for ablation (group AT) and compared with 8 patients with paroxysmal atrial fibrillation who underwent PV isolation (group Paf), and 13 patients with idiopathic ventricular tachycardia successfully treated by ablation (group VT). Time and frequency domain analysis of HRV on 24-hour ambulatory ECG recordings was performed before and after ablation. Root mean square of differences of consecutive N-N intervals (rMSSD), percentage of difference between consecutive N-N intervals >50 ms (pNN50), and high frequency (HF) component were measured to examine the effects on parasympathetic nerve activity. In group AT, rMSSD, pNN50, and HF decreased significantly after ablation, while they remained unchanged in group Paf and group VT. These observations suggest that parasympathetic denervation after ablation was limited to group AT, and depended on the site of energy delivery along the tricuspid or mitral valve as opposed to atrial or ventricular muscle.
authors.affiliation: First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Kongo
authors.forename: Eitaro
authors.initials: E
authors.lastname: Fujii
authors.forename: Koji
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Fumiya
authors.initials: F
authors.lastname: Uchida
authors.forename: Setsuya
authors.initials: S
authors.lastname: Okubo
authors.forename: Atsunobu
authors.initials: A
authors.lastname: Kasai
authors.forename: Chikaya
authors.initials: C
authors.lastname: Omichi
authors.forename: Naoki
authors.initials: N
authors.lastname: Isaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D017115:Catheter Ablation; D005260:Female; D006325:Heart Atria; D006339:Heart Rate / Q000502:physiology*; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D013610:Tachycardia / Q000503:physiopathology* / Q000601:surgery*