Synthesis of 10- and 9-membered dilactams derived from aspartic and glutamic acids.
9- and 10-membered bridged dipeptides derived from L-aspartic acid and L- or D-glutamic acid were synthesized using aminoacyl incorporation reaction. Key intermediates containing internal pyroglutamyl moiety were prepared via side chain to backbone cyclization of related protected dipeptide derivatives of glutamic acid.
Chulin
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AN
Laboratory of Peptide Chemistry, Branch of Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Pushchino, Moscow Region, Russia.
Rodionov
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IL
Ivanov
V T
VT
D001224:Aspartic Acid / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis; D004151:Dipeptides / Q000138:chemical synthesis*; D018698:Glutamic Acid / Q000737:chemistry*; D007769:Lactams / Q000138:chemical synthesis*
D001952:Bridged-Ring Compounds; D004151:Dipeptides; D007769:Lactams; D001224:Aspartic Acid; D018698:Glutamic Acid