Converting relapsing remitting to secondary progressive experimental allergic encephalomyelitis (EAE) by ultraviolet B irradiation.
We induced experimental allergic encephalomyelitis (EAE) in SJL/J mice, an animal model for multiple sclerosis (MS), using myelin oligodendrocyte glycoprotein (MOG)(92-106) peptide, following ultraviolet (UV) irradiation. While all control mice developed relapsing-remitting (RR)-EAE, UV irradiation induced secondary progressive (SP)-EAE in some of the mice. Although mild demyelination was observed with T cell infiltration in RR-EAE, large demyelinating lesions developed in SP-EAE with massive macrophage and neutrophil infiltration and immunoglobulin deposition, but with little T cell infiltration. UV irradiation induced higher anti-MOG antibody responses. In SP-EAE, lymphoproliferative responses and interferon-gamma production were decreased without alteration of interleukin-4.
Tsunoda
Ikuo
I
Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132-2305, USA.
Kuang
Li-Qing
LQ
Igenge
Isaac Z M
IZ
Fujinami
Robert S
RS
D000595:Amino Acid Sequence; D000818:Animals; D002465:Cell Movement / Q000276:immunology / Q000528:radiation effects; D002490:Central Nervous System / Q000473:pathology / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood / Q000528:radiation effects; D007136:Immunoglobulins / Q000378:metabolism / Q000528:radiation effects; D008213:Lymphocyte Activation / Q000528:radiation effects; D008264:Macrophages / Q000473:pathology / Q000528:radiation effects; D051379:Mice; D008969:Molecular Sequence Data; D020528:Multiple Sclerosis, Chronic Progressive / Q000209:etiology* / Q000276:immunology / Q000473:pathology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000209:etiology* / Q000276:immunology / Q000473:pathology*; D009185:Myelin Proteins; D009186:Myelin Sheath / Q000473:pathology / Q000528:radiation effects; D018992:Myelin-Associated Glycoprotein / Q000008:administration & dosage / Q000276:immunology; D063308:Myelin-Oligodendrocyte Glycoprotein; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000473:pathology / Q000528:radiation effects; D014466:Ultraviolet Rays
D007074:Immunoglobulin G; D007136:Immunoglobulins; C571326:MOG protein, human; C571327:Mog protein, mouse; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein