title: VEGF and VEGF receptor-1 concentration in vestibular schwannoma homogenates correlates to tumor growth rate.
abstract: OBJECTIVE
  Vascular endothelial growth factor (VEGF) is one of the most potent mediators of angiogenesis, which is a mandatory process during tumor growth. Immunohistochemical studies have demonstrated VEGF expression in vestibular schwannomas (VS), and a semi-quantitation of staining intensity indicated a correlation between tumor growth rate and VEGF expression. The present objectives were to determine the concentration of VEGF and the high-affinity receptor VEGFR-1 in VS homogenates and to examine a possible correlation with symptom duration, tumor size, or growth rate.
  
  
  METHODS
  Prospective selection of 27 patients with VS growth determined by repeated magnetic resonance imaging. Patient files were reviewed for symptom duration and all magnetic resonance images reviewed for determination of tumor size and growth rate. ELISA was used for determination of the VEGF and VEGFR-1 concentration in tumor homogenates.
  
  
  METHODS
  Tertiary University Hospital Clinic.
  
  
  RESULTS
  All tumor homogenates contained VEGF and VEGFR-1. A significant correlation existed between the concentration of both VEGF and VEGFR-1 and tumor growth rate but not symptom duration or tumor size.
  
  
  CONCLUSIONS
  The concentration of VEGF and VEGFR-1 in VS homogenates correlates with tumor growth rate but not with tumor size or symptom duration. We conclude that VEGF and VEGFR-1 appear to be directly involved in the growth pattern of VS.
authors.affiliation: Department of Oto-rhino-laryngology, Head and Neck Surgery, Gentofte University Hospital of Copenhagen, Hellerup, Denmark. pcaye@dadlnet.dk
authors.forename: Per
authors.initials: P
authors.lastname: Cayé-Thomasen
authors.forename: Kim
authors.initials: K
authors.lastname: Werther
authors.forename: Amarnadh
authors.initials: A
authors.lastname: Nalla
authors.forename: Thorkild C
authors.initials: TC
authors.lastname: Bøg-Hansen
authors.forename: Hans Jørgen
authors.initials: HJ
authors.lastname: Nielsen
authors.forename: Sven-Eric
authors.initials: SE
authors.lastname: Stangerup
authors.forename: Jens
authors.initials: J
authors.lastname: Thomsen
mesh_terms: D000328:Adult; D002455:Cell Division / Q000502:physiology; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology*; D009464:Neuroma, Acoustic / Q000098:blood supply / Q000473:pathology* / Q000601:surgery; D011446:Prospective Studies; D013223:Statistics as Topic; D046509:Tissue Culture Techniques; D047368:Tumor Burden / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000032:analysis*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1