title: Optimal cutoff point of glutamate decarboxylase antibody titers in differentiating two subtypes of adult-onset latent autoimmune diabetes.
abstract: The optimal cutoff point of glutamate decarboxylase antibody (GAD-Ab) titers for differentiating two latent autoimmune diabetes (LADA) subtypes remains unclear. One hundred and forty-five GAD-Ab-positive patients screened from phenotypic type 2 diabetes were diagnosed as LADA. The clinical features were compared among LADA patients with different GAD-Ab titers. The receiver-operating characteristic (ROC) curve was used to evaluate the diagnostic value of GAD-Ab titers and to define the optimal cutoff point. The heterogeneity of clinical features in LADA could be discriminated by five GAD-Ab titers, with maximal differences at the titer of 175 U/mL. The ROC curve analysis showed that the optimal cutoff point for discriminating two LADA subtypes was at the titer of 175 U/mL, with sensitivity and specificity of 54.5% and 92.1%, respectively. These findings demonstrated that the two clinically distinct subtypes of LADA can be optimally discriminated by the GAD-Ab titers.
authors.affiliation: Diabetes Center, Second Xiangya Hospital, Central South University, 139 Renmin Zhong Road, Changsha, Hunan 410011, China. zhouzg@hotmail.com
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: Z G
authors.initials: ZG
authors.lastname: Zhou
authors.forename: G
authors.initials: G
authors.lastname: Huang
authors.forename: X
authors.initials: X
authors.lastname: Yan
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: X Y
authors.initials: XY
authors.lastname: Chen
authors.forename: J P
authors.initials: JP
authors.lastname: Wang
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000145:classification* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000145:classification* / Q000276:immunology; D005215:Fasting; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D011863:Radioimmunoassay; D012680:Sensitivity and Specificity
chemical_list: D000906:Antibodies; D002096:C-Peptide; D005968:Glutamate Decarboxylase