A highly unusual cluster of acute promyelocytic leukaemia: an environmental aetiology?
We report three consecutive cases of acute promyelocytic leukaemia (APML) that were diagnosed within a 4-month period. This unexpected sequence of events was made all the more notable following our discovery of co-incidental geographic, social, and occupational factors that linked them together. Our data strongly suggests that environmental agents may play a greater role in the aetiology of APML than is commonly perceived.
Murrin
R J A
RJ
Department of Haematology, Russells Hall Hospital, Dudley, West Midlands, UK. richard.murrin2@swbh.nhs.uk
Harrison
P
P
Neilson
J R
JR
D000328:Adult; D016000:Cluster Analysis; D004781:Environmental Exposure; D005260:Female; D033062:Friends; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology