title: Dose-response feeding study of chlorinated paraffins in broiler chickens: effects on growth rate and tissue distribution.
abstract: Even with the highest additions of 100mg kg(-1) short-chain (C10-C13) chlorinated paraffins (CP) to feed, the health of broilers was not adversely affected during a 31-day feeding experiment. In addition, 1 and 3 weeks after the experiment started, growth rate and feed consumption of the young animals were not impaired. No significant influence on mortality, organ weight relative to live weight or performance (weight gain, feed consumption) was noted. The CP concentrations in abdominal fat, meat, liver and kidneys were related linearly to the CP concentration of the feed. The highest contents were analysed in fat and the faeces, and the lowest concentrations were found in blood, meat and bile fluid. Less than 5% of the CP amount consumed was incorporated into the body, without taking the head, gut, feet and feathers into account.
authors.affiliation: Institute of Animal Nutrition, Federal Agricultural Research Centre, Braunschweig (FAL), D-29223 Celle, Germany. karl.ueberschaer@fal.de
authors.forename: K H
authors.initials: KH
authors.lastname: Ueberschär
authors.forename: S
authors.initials: S
authors.lastname: Matthes
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002645:Chickens / Q000254:growth & development / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D006843:Hydrocarbons, Chlorinated / Q000493:pharmacokinetics / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010232:Paraffin / Q000493:pharmacokinetics / Q000633:toxicity*; D014018:Tissue Distribution; D015430:Weight Gain / Q000187:drug effects
chemical_list: D006843:Hydrocarbons, Chlorinated; D010232:Paraffin