title: Ability of CD8+ T cell anti-feline immunodeficiency virus (FIV) activity and FIV proviral DNA load in mononuclear cells in FIV-infected cats.
abstract: We investigated the relationship between CD8+ T cell anti-feline immunodeficiency virus (FIV) activity and FIV proviral DNA load integrated in mononuclear cells. The anti-FIV activity and the proviral DNA load were correlated, and the number of proviral DNA copies was high in cats with decreased anti-FIV activity. Particularly, no anti-FIV activity was detected in the cats staged as having an acquired immunodeficiency syndrome (AIDS)-related complex or AIDS, and the number of proviral DNA copies was obviously increased compared to those in the cats in the asymptomatic stage. These results suggest that decreased anti-FIV activity destroys the control of in vivo FIV replication, which leads to an increased proviral DNA load with the progression of the clinical stage of disease.
authors.affiliation: Department of Veterinary Infectious Diseases, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hohdatsu
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Isao
authors.initials: I
authors.lastname: Saito
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koyama
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D002415:Cats; D016181:Feline Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D016089:Immunodeficiency Virus, Feline / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D011533:Proviruses; D019562:Viral Load / Q000662:veterinary*; D014779:Virus Replication