title: Aspochalamins A-D and aspochalasin Z produced by the endosymbiotic Fungus Aspergillus niveus LU 9575. II. Structure elucidation.
abstract: The structures of new cytochalasan fungal metabolites aspochalamins A-D have been elucidated by ESI-FTICR-MS, NMR spectroscopy, and chiral amino acid analysis. Aspochalamins A-D consist of different aspochalasin skeletons connected at position C-19 to the N terminus of the tripeptidic moiety amide anthranoyl-L-alanine-E-didehydrotryptamide. Furthermore, the structure of a new aspochalasin analog, aspochalasin Z, was derived from its molecular mass and NMR data as 10-isopropyl-14-methyl[11]-cytochalasa-6Z,13E,19E-triene-1,21-dione.
authors.affiliation: Institut für Organische Chemie, Universität Tübingen, Auf der Morgenstelle 18, D-72076 Tübingen, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Holtzel
authors.forename: Dietmar G
authors.initials: DG
authors.lastname: Schmid
authors.forename: Graeme J
authors.initials: GJ
authors.lastname: Nicholson
authors.forename: Philipp
authors.initials: P
authors.lastname: Krastel
authors.forename: Axel
authors.initials: A
authors.lastname: Zeeck
authors.forename: Klaus
authors.initials: K
authors.lastname: Gebhardt
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
authors.forename: Günther
authors.initials: G
authors.lastname: Jung
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001230:Aspergillus / Q000737:chemistry / Q000378:metabolism*; D003572:Cytochalasins / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D003572:Cytochalasins; C497074:aspochalamin A; C497077:aspochalamin B; C497076:aspochalamin C; C497075:aspochalamin D