Artificial diiron proteins: from structure to function.
De novo protein design provides an attractive approach for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. In this article, we summarize the design, structure determination, and functional properties of a family of artificial diiron proteins.
Calhoun
Jennifer R
JR
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nastri
Flavia
F
Maglio
Ornella
O
Pavone
Vincenzo
V
Lombardi
Angela
A
DeGrado
William F
WF
D000595:Amino Acid Sequence; D020134:Catalytic Domain; D019281:Dimerization; D007501:Iron / Q000737:chemistry; D008667:Metalloproteins / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D020836:Protein Structure, Quaternary; D055672:Static Electricity; D013816:Thermodynamics
D008667:Metalloproteins; D007501:Iron