title: Electrophilic properties of nitroheterocyclic compounds. Potential hypoxic cells radiosensitizers.
abstract: Investigation of the reduction potential and calculation of the partition coefficient n-octanol/water allow the assessment of the potential suitability of nitropirydine N-oxide compounds in radiotherapy of cancer. Experiments were carried out using cyclic voltammetry with HMDE as working electrode. The electrode reduction of the investigated compounds is quite irreversible and strongly dependent on pH.
authors.affiliation: Faculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie Str., 50-383 Wrocław, Poland. zieba@wchuwr.chem.uni.wroc.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Zieba-Mizgała
authors.forename: Aniela
authors.initials: A
authors.lastname: Puszko
authors.forename: Andrzej
authors.initials: A
authors.lastname: Regiec
authors.forename: Janina
authors.initials: J
authors.lastname: Kuduk-Jaworska
mesh_terms: D003497:Cyclic N-Oxides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D004566:Electrodes; D000860:Hypoxia / Q000473:pathology / Q000532:radiotherapy*; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy; D010084:Oxidation-Reduction; D011838:Radiation-Sensitizing Agents / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D003497:Cyclic N-Oxides; D011838:Radiation-Sensitizing Agents