title: The tetraspanin web modulates immune-signalling complexes.
abstract: The tetraspanin web represents a new concept of molecular interactions in the immune system. Whereas most surface immune-modulating molecules involve receptor-ligand interactions, tetraspanins associate with partner proteins and facilitate their lateral positioning in the membrane. Moreover, the same tetraspanin molecule can associate with different proteins depending on the cell type. Most importantly, members of this family tend to associate with each other, together with their partners, in membrane microdomains that provide a scaffold for the transmission of external stimuli to intracellular-signalling components.
authors.affiliation: Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, California 94305, USA. levy@cmgm.stanford.edu
authors.forename: Shoshana
authors.initials: S
authors.lastname: Levy
authors.forename: Tsipi
authors.initials: T
authors.lastname: Shoham
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D002462:Cell Membrane / Q000737:chemistry*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008565:Membrane Proteins / Q000737:chemistry* / Q000502:physiology*; D020239:Receptor Cross-Talk / Q000276:immunology; D015398:Signal Transduction / Q000502:physiology*; D060225:Tetraspanin 28
chemical_list: D015703:Antigens, CD; C554798:CD81 protein, human; D008565:Membrane Proteins; D060225:Tetraspanin 28