title: Functional connectivity changes with concentration of sevoflurane anesthesia.
abstract: Low-frequency oscillations (<0.08 Hz) have been detected in functional magnetic resonance imaging studies, and appear to be synchronized between functionally related areas. The effect of anesthetic agents on cortical activity is not completely characterized. This study assessed the effect of anesthesia on the temporal relations in activity in the motor cortices. Resting-state magnetic resonance data were acquired on six volunteers under different anesthetic states (using 0.0%, 2.0% and 1.0% stable end-tidal sevoflurane). Across all volunteers, the number of significant voxels (p<2.5 x 10) in the functional connectivity maps was reduced by 78% for light anesthesia and by 98% for deep anesthesia, compared with the awake state. Additionally, significant correlations in the connectivity maps were bilateral in the awake state but unilateral in the light anesthesia state.
authors.affiliation: Department of Biomedical Engineering, Emory University/Georgia Tech, Emory University, Atlanta, GA 30322, USA. speltier@bme.emory.edu
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Peltier
authors.forename: Chantal
authors.initials: C
authors.lastname: Kerssens
authors.forename: Stephan B
authors.initials: SB
authors.lastname: Hamann
authors.forename: Peter S
authors.initials: PS
authors.lastname: Sebel
authors.forename: Michael
authors.initials: M
authors.lastname: Byas-Smith
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hu
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001931:Brain Mapping; D004305:Dose-Response Relationship, Drug; D007839:Functional Laterality / Q000187:drug effects; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D009044:Motor Cortex / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects*; D000077149:Sevoflurane; D014851:Wakefulness / Q000187:drug effects
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane