title: Pregnancies and deliveries in patients with Charcot-Marie-Tooth disease.
abstract: OBJECTIVE
  To investigate the effect of maternal Charcot-Marie-Tooth disease (CMT) on pregnancy and delivery.
  
  
  METHODS
  Data from the Medical Birth Registry of Norway 1967 to 2002 were surveyed. This registry has compulsory notification of all births. One hundred eight births by mothers with CMT were identified. The reference group consisted of all 2.1 million births by mothers without CMT.
  
  
  RESULTS
  Women with CMT had a higher occurrence of presentation anomalies (9.3 vs 4.5%; p = 0.04) and bleeding post partum (12.0 vs 5.8%; p = 0.02). The rate of operative delivery was twice that of the reference group (29.6 vs 15.3%; p = 0.002), and forceps was used three times as often in the CMT group (9.3 vs 2.7; p < 0.001). The majority of CMT cesarean sections were emergency sections.
  
  
  CONCLUSIONS
  Charcot-Marie-Tooth disease increases the risk for complications during delivery, which is linked to a higher occurrence of emergency interventions during birth.
authors.affiliation: Section for Neurology, Department of Clinical Medicine, University of Bergen, Bergen, Norway. jana.midelfart.hoff@helse-bergen.no
authors.forename: Jana Midelfart
authors.initials: JM
authors.lastname: Hoff
authors.forename: Nils Erik
authors.initials: NE
authors.lastname: Gilhus
authors.forename: Anne Kjersti
authors.initials: AK
authors.lastname: Daltveit
mesh_terms: D000328:Adult; D001724:Birth Weight; D002585:Cesarean Section / Q000706:statistics & numerical data; D002607:Charcot-Marie-Tooth Disease / Q000453:epidemiology*; D036861:Delivery, Obstetric / Q000706:statistics & numerical data*; D004630:Emergencies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007746:Labor Presentation; D008297:Male; D009664:Norway / Q000453:epidemiology; D007744:Obstetric Labor Complications / Q000453:epidemiology; D009772:Obstetrical Forceps / Q000706:statistics & numerical data; D010298:Parity; D019106:Postoperative Hemorrhage / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011644:Puerperal Disorders / Q000453:epidemiology; D012189:Retrospective Studies; D012306:Risk; D014592:Uterine Hemorrhage / Q000453:epidemiology; D014620:Vacuum Extraction, Obstetrical / Q000706:statistics & numerical data