Cell signaling: wingless and glypicans together again.
The role of the Glypican proteoglycans in Wingless signaling has been controversial. New studies show that the Glypican Dally-like can have both positive and negative effects on Wingless signaling; moreover, signaling can be regulated by removing Dally-like from the cell surface.
Blair
Seth S
SS
Department of Zoology, University of Wisconsin, 250 North Mills St., Madison, Wisconsin 53706, USA. ssblair@wisc.edu
D000818:Animals; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism* / Q000502:physiology; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism* / Q000502:physiology; D008562:Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D011509:Proteoglycans / Q000378:metabolism / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014921:Wings, Animal / Q000502:physiology; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D019812:Heparan Sulfate Proteoglycans; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011509:Proteoglycans; D011518:Proto-Oncogene Proteins; D051155:Wnt1 Protein; C098128:dally protein, Drosophila; C420997:dlp protein, Drosophila; C074622:wg protein, Drosophila