title: Interaction of Helicobacter pylori with host cells: function of secreted and translocated molecules.
abstract: Secreted proteins are of general interest from the perspective of bacteria-host interaction. The gastric bacterial pathogen Helicobacter pylori uses a set of secreted and translocated proteins--including outer membrane adhesins, secreted extracellular enzymes and translocated effector proteins--to adapt to its extraordinary habitat, the gastric mucosa. Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system and its translocated effector protein, cytotoxin-associated antigen A (CagA). VacA targets not only epithelial cells, but also cells of the immune system and induces immunosuppression. CagA has been shown to interact with a growing set of eucaryotic signaling molecules in phosphorylation-dependent and -independent ways.
authors.affiliation: Max von Pettenkofer-Institut, Ludwig-Maximilians-Universität München, Pettenkoferstrasse 9a, 80336 München, Germany.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Rieder
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Fischer
authors.forename: Rainer
authors.initials: R
authors.lastname: Haas
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D005753:Gastric Mucosa / Q000276:immunology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000382:microbiology; D016480:Helicobacter pylori / Q000378:metabolism / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D015398:Signal Transduction; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors