title: [Association between serum lipoprotein-cholesterol levels and HDL subpopulations].
abstract: OBJECTIVE
  To investigate the influence of serum HDL-C or LDL-C levels on the components of serum HDL subpopulations.
  
  
  METHODS
  Apolipoprotein (apo) A-I contents of serum HDL subpopulations in 292 subjects were determined by two-dimensional gel electrophoresis in conjunction with immunodection.
  
  
  RESULTS
  With the decrease of serum HDL-C levels, the apoA-I contents of pre beta1-HDL and HDL3b increased and were significantly higher (P<0.01; P<0.05) in the low HDL-C group than in the high HDL-C group. But on the contrary, with the decrease of serum HDL-C levels, the apoA-I contents of HDL2b and HDL2a decreased and were significantly lower (P<0.01) in the middle and low HDL-C groups than in the high HDL-C group. With the increase of serum LDL-C levels, the apoA-I contents of pre beta1-HDL, HDL3C and HDL3b increased; the apoA-I contents of pre beta1-HDL and HDL3b were significantly higher in the high LDL-C group (P<0.05) and very high LDL-C group (P<0.01), and those of HDL3C were also significantly higher in the very high LDL-C group (P<0.01). But on the contrary, with the increase of LDL-C levels, the apoA-I contents of HDL2b decreased and were significantly lower in the high LDL-C group (P<0.05) and very high LDL-C group (P<0.01) when compared with the apoA-I contents of the desirable LDL-C group.
  
  
  CONCLUSIONS
  With the decrease of serum HDL-C levels or increase of serum LDL-C levels, the small-sized HDL increased and the large-sized HDL decreased; furthermore, the HDL-C levels were more closely related to the components of the large-sized HDL (HDL2a, HDL2b).
authors.affiliation: Biochemistry and Molecular Biology Laboratory, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
authors.forename: Lan-tu
authors.initials: LT
authors.lastname: Gou
authors.forename: Ming-de
authors.initials: MD
authors.lastname: Fu
authors.forename: Yan-hua
authors.initials: YH
authors.lastname: Xu
authors.forename: Bing-yu
authors.initials: BY
authors.lastname: Yan
authors.forename: Yu-ye
authors.initials: YY
authors.lastname: Yang
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D015180:Electrophoresis, Gel, Two-Dimensional; D053442:High-Density Lipoproteins, Pre-beta; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood* / Q000145:classification*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D053442:High-Density Lipoproteins, Pre-beta; D008075:Lipoproteins, HDL