[Investigation of the hepatoprotector action of natural flavonoids].
The prophylactic hepatoprotective properties of a series of natural flavonoids (hesperidin from citrus peel, diosmine from Vicia tanuifolia Roth., and diosmine analog from Vicia trunctula) were studied in a group of white male rats with a model of acute CCl4 hepatitis. The effect was evaluated by the ability of tested substances to normalize the biochemical characteristics of the functional state of the liver, in comparison to the reference drug carsil. The most pronounced hepatoprotective action was observed for diosmine analog administered in a dose of 100 mg/kg, which was superior in some respects to the reference hepatoprotector (in equivalent doses). This is probably related to the higher bioaccessibility of diosmine analog ensured by a carbohydrate moiety of this compound, in combination with the C2-C3 double bond present in diosmetin (diosmin aglycon).
Dorkina
E G
EG
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000503:physiopathology; D002957:Citrus / Q000737:chemistry*; D044950:Flavanones / Q000008:administration & dosage* / Q000302:isolation & purification; D006520:Hepatitis, Animal / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D020011:Protective Agents / Q000008:administration & dosage; D051381:Rats; D012838:Silymarin / Q000008:administration & dosage; D031306:Vicia / Q000737:chemistry*
D044950:Flavanones; D020011:Protective Agents; D012838:Silymarin