title: Synthetic fragments of antigenic lipophosphoglycans from Leishmania major and Leishmania mexicana and their use for characterisation of the Leishmania elongating alpha-D-mannopyranosylphosphate transferase.
abstract: The phosphorylated branched heptasaccharides 7 and 8, the octasaccharide 9 and the phosphorylated trisaccharides 5 and 6, which are fragments of the phosphoglycan portion of the surface lipophosphoglycans from Leishmania mexicana (5) or L. major (6-9), were synthesised by using the glycosyl hydrogenphosphonate method for the preparation of phosphodiester bridges. The compounds were tested as acceptor substrates/putative inhibitors for the Leishmania elongating alpha-D-mannosylphosphate transferase.
authors.affiliation: Faculty of Life Sciences, Division of Biological Chemistry and Molecular Microbiology, University of Dundee (Carnelley Building), Dundee DD1 4HN, Scotland, UK.
authors.forename: Adrian P
authors.initials: AP
authors.lastname: Higson
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Ross
authors.forename: Yury E
authors.initials: YE
authors.lastname: Tsvetkov
authors.forename: Françoise H
authors.initials: FH
authors.lastname: Routier
authors.forename: Olga V
authors.initials: OV
authors.lastname: Sizova
authors.forename: Michael A J
authors.initials: MA
authors.lastname: Ferguson
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Nikolaev
mesh_terms: D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006028:Glycosphingolipids / Q000138:chemical synthesis* / Q000737:chemistry; D018320:Leishmania major / Q000737:chemistry*; D007894:Leishmania mexicana / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D014166:Transferases / Q000737:chemistry
chemical_list: D006028:Glycosphingolipids; C008290:lipophosphonoglycan; D014166:Transferases