title: Design and analysis of in vitro experiments for combination chemotherapy.
abstract: A method is proposed for the evaluation of in vitro experiments for combination chemotherapy, a new and growing area of cancer research. We first describe and review a popular graphical device called an isobologram. We then propose a statistical framework, a simple experimental design, and a statistical test for use with this widely accepted methodology. The test we propose is a score test based on the linear logistic regression model.
authors.affiliation: School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA. chap@biostat.umn.edu
authors.forename: T
authors.initials: T
authors.lastname: Le Chap
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Grambsch
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006801:Humans; D016014:Linear Models; D008954:Models, Biological; D015233:Models, Statistical; D012107:Research Design / Q000706:statistics & numerical data*