title: Evaluation of caffeic acid amide analogues as anti-platelet aggregation and anti-oxidative agents.
abstract: A series of amides of caffeic acid were synthesized and evaluated for their anti-platelet and anti-oxidative activities. N-(2-Bromo-phenyl)-3-(3,4-dihydroxy-phenyl)-acrylamide (12) and N-(3-Bromo-phenyl)-3-(3,4-dihydroxy-phenyl)-acrylamide (13) exhibited potent inhibitory activity (IC(50)=5.8 and 6.7 microM, respectively) against arachidonic acid-induced (AA) platelet aggregation, comparable with invalid caffeic acid. Most of the synthesized caffeic acid anilides exhibited the promising anti-platelet aggregation in AA-induced assay and anti-oxidative activities. This study also exhibited that caffeic anilides displayed more potent anti-oxidative activity in the radical scavenging activity assay than trolox and vitamin E.
authors.affiliation: National Research Institute of Chinese Medicine, Shin-Pai, Taipei 112, Taiwan.
authors.forename: Chia-Cheng
authors.initials: CC
authors.lastname: Hung
authors.forename: Wei-Jen
authors.initials: WJ
authors.lastname: Tsai
authors.forename: Li-Ming Yang
authors.initials: LM
authors.lastname: Kuo
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000577:Amides / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D002109:Caffeic Acids / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D000577:Amides; D000975:Antioxidants; D002109:Caffeic Acids; D010975:Platelet Aggregation Inhibitors; C040048:caffeic acid