title: [Studies on mechanism of antiasthmatic and anti-inflammatory actions of CDCA].
abstract: OBJECTIVE
  To observe antiasthmatic and anti-inflammatory actions mechanisms of CDCA.
  
  
  METHODS
  The content of NO was determined by method of nitroreductase chromatometry in serum and trachea tissue. The content of cAMP was analysed by method of competitive protein-binding assay. The content of PGE2 was determined by method of ultraviolet spectrophotometry.
  
  
  RESULTS
  CDCA significantly decreased the content of NO of serum and trachea tissue in mice. CDCA increased greatly the content of cAMP of trachea tissue in rats. CDCA significantly decreased the content of PGE2 of trachea and lung tissue in mice.
  
  
  CONCLUSIONS
  Mechanisms of antiasthmatic and anti-inflammatory actions of CDCA are related to increasing the content of cAMP in trachea tissue and decreasing the constituent of NO and PGE2 in body.
authors.affiliation: The College of Animal Science and Medicine, Inner Mongolia Agricultural University, Huhhhot 010018, China. lpeifeng@imau.edu.cn
authors.forename: Pei-feng
authors.initials: PF
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Guan
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Zhao
authors.forename: Qin
authors.initials: Q
authors.lastname: Si
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002635:Chenodeoxycholic Acid / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D008168:Lung / Q000378:metabolism; D008297:Male; D008419:Materia Medica / Q000494:pharmacology; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014132:Trachea / Q000378:metabolism
chemical_list: D018927:Anti-Asthmatic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008419:Materia Medica; D002635:Chenodeoxycholic Acid; D009569:Nitric Oxide; D000242:Cyclic AMP; D015232:Dinoprostone