title: Auditory and visual P300 evoked potentials do not predict response to valproate treatment of aggression in patients with borderline and antisocial personality disorders.
abstract: In this study of patients with borderline personality disorder (BPD) or antisocial personality disorder (ASPD) hospitalized because of aggressive behavior, auditory and visual P300 evoked potentials were obtained prior to treatment with valproate. Eight ASPD patients (8 males, 0 females) and 11 BPD patients (2 males, 9 females) showed improvement, while in 7 patients with ASPD (7 males, 0 females) and 10 patients with BPD (2 males, 8 females), aggression was not improved. Differences in auditory and visual P300 latencies and amplitudes were not significant for either diagnosis, or for both diagnoses combined. These findings suggest that auditory or visual P300 evoked potentials may not be useful for predicting response of aggressive behavior to valproate treatment in patients with BPD or ASPD.
authors.affiliation: Montgomery VA Medical Center and Professor of Psychiatry and Neurology at the University of Mississippi School of Medicine, Jackson, MS 39216, USA. roy.reeves@med.va.gov
authors.forename: Roy R
authors.initials: RR
authors.lastname: Reeves
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Struve
authors.forename: Gloria
authors.initials: G
authors.lastname: Patrick
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects*; D000927:Anticonvulsants / Q000627:therapeutic use*; D000987:Antisocial Personality Disorder / Q000188:drug therapy*; D001883:Borderline Personality Disorder / Q000188:drug therapy*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300; D005072:Evoked Potentials, Auditory; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid