title: [Effect of high-oxygen water on enhancing anoxia endurance and anti-fatigue function and the possible mechanism].
abstract: OBJECTIVE
  To investigate the effect of high-oxygen water on anoxia endurance and anti-fatigue function in mice and explore the possible mechanism.
  
  
  METHODS
  KM mice were used. Their body weight, serum urea nitrogen, hepatic glycogen, swimming-sustaining time of mice with a load, plasma lactic acid content, survival time under anoxia or sodium nitrite poisoning were measured.
  
  
  RESULTS
  It was found that high-oxygen water can prolong swimming time and can protract the anoxia survival time of mice under normal pressure and being afflicted with acute cerebral ischemia (P<0.05). It can also decrease the level of serum urea nitrogen after exercise (P<0.05) and increase hepatic glycogen storage (P<0.05).
  
  
  CONCLUSIONS
  The results demonstrate that high-oxygen water can enhance the emergent survival ability of mice, the ability of fatigue recovery and anoxia endurance function. It also can increase the energy storage.
authors.affiliation: Department of Medical Technology, West China School of Public Health, Sichuan University, Chengdu 610041, China.
authors.forename: Heng-chuan
authors.initials: HC
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Zao-ping
authors.initials: ZP
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D005221:Fatigue / Q000517:prevention & control*; D000860:Hypoxia / Q000503:physiopathology*; D002534:Hypoxia, Brain / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism; D010100:Oxygen / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000187:drug effects*; D014867:Water / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D014867:Water; D019344:Lactic Acid; D010100:Oxygen