Synthesis and characterization of polyester dendrimers from acetoacetate and acrylate.
New aliphatic polyester-type dendrimers were synthesized using a new AB2-type building block 3, prepared from benzyl acetoacetate and 2 equiv of tert-butyl acrylate by acetoacetic acid ester synthesis. The reiterative [deprotection by HCO2H, then EDCI/DMAP coupling] sequence using divergent growth method gave [G1]-4tBu-[G5]-64tBu dendrimers. 13C NMR relaxation time (T1) measurements on the carboxy carbons show that the extended chain conformations are predominant in CDCl3. [structure: see text]
Hirayama
Yuuki
Y
Department of Biomolecular Science and School of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
Nakamura
Taisuke
T
Uehara
Satoshi
S
Sakamoto
Yohko
Y
Yamaguchi
Kentaro
K
Sei
Yoshihisa
Y
Iwamura
Michiko
M
D000090:Acetoacetates; D000179:Acrylates; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
D000090:Acetoacetates; D000179:Acrylates; D050091:Dendrimers; D011091:Polyesters; C016635:acetoacetic acid