[Genetic Predictors of Unfavorable Course in High Risk Patients With Ischemic Heart Disease. Data of Follow-up for Two Years.].
Prognostic value of clinical parameters and polymorphisms of apo-B, apo-E, LPL, , PPARA, PPARG2 genes was studied in 154 patients with acute unstable angina. Duration of follow-up was 2 years. Diabetes (OR 3.29, 1.28-8.50, p=0.014), history of stroke (OR 6.11, 1.21-31.00, p=0.029), changes of terminal part of ventricular complex on ECG, recorded during acute phase of ischemic heart disease (OR 2.19, 1.01-4.57, p=0.046), and genotype II of polymorphic marker ID of apoB gene (OR 2.20, 1.06-4.57, p=0.027) were independent predictors of unfavorable course of ischemic heart disease. Thus genetic factors play a role not only in formation of coronary atherosclerosis but determine the course of ischemic heart disease.
Zateĭshchikov
D A
DA
Presidential Medical Center of Russia; ul. Marshala Timoshenko, 15, 121356 Moscow, Russia; State RF Research Center "Genetics", Moscow.
Chumakova
O S
OS
Zateĭshchikova
A A
AA
Zotova
I V
IV
Minushkina
L O
LO
Chudakova
D A
DA
Nosikov
V V
VV
Sidorenko
B A
BA
D000789:Angina, Unstable; D001055:Apolipoproteins B; D003324:Coronary Artery Disease; D005500:Follow-Up Studies; D006801:Humans; D017202:Myocardial Ischemia; D012307:Risk Factors
D001055:Apolipoproteins B