[A preliminary observation of bone marrow angiogenesis in patients with myelodysplastic syndromes].
OBJECTIVE
To observe the change of angiogenesis in the bone marrow of patients with myelodysplastic syndromes, and to explore its effect on this disease.


METHODS
The sera of 20 patients with myelodysplastic syndromes and 20 normal controls were collected; the level of serum vascular endothelial growth factor (S-VEGF) was measured by ELISA; and the microvessel density (MVD) of marrow biopsy specimens was examined with the streptavidine-biovatidine immunoperoxidase method; the count of MVD was evaluated with image analysis system.


RESULTS
The level of S-VEGF and count of MVD were higher than that of normal control, and both significantly elevated in MDS/MPD and RAEB-t subtypes. The S-VEGF was positively related with MVD (P<0.05), and S-VEGF and MVD were closely related with the percentage of blast in marrow and in peripheral blood.


CONCLUSIONS
The result shows that there is abnormal angiogenesis in MDS bone marrow, and the elevated levels of S-VEGF and MVD are closely related with a progressive status in myelodysplastic syndromes.
Zou
Wen-rong
WR
Division of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China.
Liu
Ting
T
Meng
Wen-tong
WT
Yu
Jiang
J
Niu
Ting
T
D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000098:blood supply* / Q000276:immunology / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000473:pathology*; D009389:Neovascularization, Pathologic; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A