[Allosteric modulators of AMPA type glutamate receptors a novel gubclass of physiologically active substances].
Properties of AMPA type glutamate receptors widely presented within mammalian central nervous system are reviewed. AMPA receptors belong to ionotropic subclass of glutamate receptors and participate in fast excitatory glutamatergic transmission in the brain. Molecular structure of AMPA receptors consists of several subunits (GluRA1-GluRA4), which display various sensitivity to receptor ligands. These receptors are named according to their selective agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). AMPA receptor modulators represented by several chemical groups: pyrrolidinones (aniracetam), benzothiodiazinedioxides, benzylpiperidines and biarylpropylsulphonamides. These compounds facilitate AMPA receptor-mediated glutamatergic neurotransmission. AMPA receptor modulators enhance cognitive functions (learning and memory), reveal anxiolytic and antidepressant action, suppress the effects of psychostimulant agents, potentiate the effects of antipsychotic drugs, display neuroprotective properties. Positive modulation of AMPA receptor-associated ionic channels was shown to underline the mode of action of these substances that results in enhancement of long-term potentiation (LTP) and increasing neurotrophic factors expression. Preliminary clinical results have shown positive therapeutic effect of these substances in patients with cognitive impairment.
Raevskiĭ
K S
KS
Eremin
K O
KO
D000818:Animals; D003072:Cognition Disorders / Q000188:drug therapy / Q000378:metabolism; D018690:Excitatory Amino Acid Agonists / Q000145:classification / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D018091:Receptors, AMPA / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
D018690:Excitatory Amino Acid Agonists; D007473:Ion Channels; D018091:Receptors, AMPA