title: Two new biologically active illudane sesquiterpenes from the mycelial cultures of Panaeolus retirugis.
abstract: Two new illudane sesquiterpenes, paneolic acid and paneolilludinic acid, along with a known antibiotic diterpene, pleuromutilin, were isolated from the mycelial solid cultures of Panaeolus retirugis. Their structures were elucidated on the basis of spectroscopic analysis. Both compounds exhibited antibacterial activity against Staphylococcus aureus, and paneolic acid showed cytotoxicity to HL60 cell with an IC50 of 18.9 microg/ml.
authors.affiliation: South China Botanical Garden, Chinese Academy of Sciences, Leyiju, Guangzhou 510650, China.
authors.forename: Wenzhe
authors.initials: W
authors.lastname: Ma
authors.forename: Yicun
authors.initials: Y
authors.lastname: Huang
authors.forename: Lidong
authors.initials: L
authors.lastname: Lin
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhu
authors.forename: Yizhu
authors.initials: Y
authors.lastname: Chen
authors.forename: Hanhong
authors.initials: H
authors.lastname: Xu
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D001487:Basidiomycota / Q000378:metabolism*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009904:Optical Rotation; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D012717:Sesquiterpenes; C497078:paneolic acid; C497079:paneolilludinic acid