Custom-made stent-grafts for aortic aneurysm repair using gianturco Z stents and woven polyester: healing in an animal model.
The purpose of this study was to evaluate the healing at 6 months of aortic stent-grafts custom-made by using Z stents and woven polyester in an animal model. Stent-grafts were built by a published method using autoexpandable stainless steel stents continuously compiled with polyester sutures and covered with a woven polyester membrane. Fourteen stent-grafts of 3 different designs were deployed under fluoroscopic control into the thoracic and the abdominal aorta of 7 adult sheep. At 6 months, all the implants of the sheep that survived the implantation were angiographed and harvested for macroscopy and microscopy. All stent-grafts were implanted successfully and remained patent from then to the explantation procedure. All stent-grafts implanted among the 6 of 7 (86%) animals that survived after the implantation remained patent, stayed free from local complications, and did not migrate during more than 6 months. In all these cases during this period, the implant functioned as a satisfactory aortic substitute while the aortic segment containing the graft kept a normal structure. There was no adverse effects of the presence of the implant upon the aorta or the animal. Stent-grafts home-made according to the described methods gave results at 6 months in this animal model compatible with a safe clinical application among humans.
Koskas
Fabien
F
Department of Vascular Surgery, CHU Pitié-Salpêtrière, Paris, France. fabien.koskas@psl.ap-hop-paris.fr
Brocheriou
Isabelle
I
Cluzel
Philippe
P
Singland
Jean-Dominique
JD
Régnier
Bruno
B
Bonnot
Michel
M
Kieffer
Edouard
E
D000818:Animals; D001011:Aorta / Q000503:physiopathology* / Q000601:surgery; D001018:Aortic Diseases / Q000209:etiology; D001672:Biocompatible Materials / Q000009:adverse effects; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects; D023421:Models, Animal; D011091:Polyesters / Q000009:adverse effects; D012756:Sheep; D015607:Stents / Q000009:adverse effects; D014945:Wound Healing / Q000502:physiology*
D001672:Biocompatible Materials; D011091:Polyesters