title: Pulsed star labeling of arterial regions (PULSAR): a robust regional perfusion technique for high field imaging.
abstract: Regional perfusion imaging (RPI) has recently been introduced as a potentially powerful technique to map the perfusion territories of patients with vascular diseases in a fully noninvasive manner. However, this technique suffers from the problems of the transfer insensitive labeling technique upon which it is based. In particular, RPI is very sensitive to magnetic field inhomogeneities, and therefore the definition of the labeled bolus can deteriorate at field strength higher than 1.5 T. Furthermore, the slab-selective triple-pulse postsaturation sequence used originally will also be impaired due to the same problem, rendering RPI unusable at higher field. In this work, an adiabatic-based signal targeting with alternating radiofrequency pulses sequence is proposed as a labeling scheme to solve the problems related to variations in local magnetic field, together with an improved four-pulse water suppression enhanced through T(1) effects technique as a presaturation scheme.
authors.affiliation: Department of Neuroradiology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433. Golay@nni.com
authors.forename: Xavier
authors.initials: X
authors.lastname: Golay
authors.forename: Esben T
authors.initials: ET
authors.lastname: Petersen
authors.forename: Francis
authors.initials: F
authors.lastname: Hui
mesh_terms: D000465:Algorithms; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010477:Perfusion; D019047:Phantoms, Imaging; D013113:Spin Labels
chemical_list: D013113:Spin Labels