title: Evolution of the theory of circulation.
abstract: The first known descriptions regarding the basic aspects of circulation was probably in 500 B.C., by the Greek thinker Alcmaeon of Croton who observed arteries and veins to be dissimilar in animal dissection, and this was followed by the description of the human heart as a three chambered organ by Aristotle in 350 B.C. Herophilus of Chalcedon, a Greek anatomist, confirmed the findings of dissimilarity between arteries and veins in human cadaver dissections in 300 B.C., and determines that arteries were thicker than veins and contained blood. The advancement by far in the learning of human circulation was made possible first by significant contribution of Galen followed by observations of Ibn al-Nafis, Servetus, Colombo, Cesalpino, Vesalius and Fabricius. In 17th century William Harvey, an English physician, made important advancements into the understanding of this important area of medicine, advancements that continued with the observations of Malpighi.
authors.forename: Ijaz A
authors.initials: IA
authors.lastname: Khan
authors.forename: Samantapudi K
authors.initials: SK
authors.lastname: Daya
authors.forename: Ramesh M
authors.initials: RM
authors.lastname: Gowda
mesh_terms: D001775:Blood Circulation; D049669:History, 16th Century; D049670:History, 17th Century; D049690:History, Ancient; D006801:Humans; D010827:Physiology / Q000266:history*