title: Differential chemosensitivity of tumor components in a malignant oligodendroglioma: assessment with diffusion-weighted, perfusion-weighted, and serial volumetric MR imaging.
abstract: We report the case of malignant oligodendroglioma in a 36-year-old man who underwent diffusion-weighted, perfusion-weighted, and volumetric MR imaging before and after PCV (procarbazine, CCNU, vincristine) chemotherapy. The tumor regions exhibiting a low apparent diffusion coefficient and increased relative cerebral blood volume showed a marked response to chemotherapy and dramatic decrease in volume, whereas the remaining tumor regions showed little change. Diffusion-weighted and perfusion-weighted MR imaging may be helpful in predicting chemosensitivity of glial tumors.
authors.affiliation: Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom.
authors.forename: Hans Rolf
authors.initials: HR
authors.lastname: Jäger
authors.forename: Adam D
authors.initials: AD
authors.lastname: Waldman
authors.forename: Christopher
authors.initials: C
authors.lastname: Benton
authors.forename: Nicholas
authors.initials: N
authors.lastname: Fox
authors.forename: Jeremy
authors.initials: J
authors.lastname: Rees
mesh_terms: D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009837:Oligodendroglioma / Q000188:drug therapy* / Q000473:pathology*