The effect of trans sodium crocetinate (TSC) in a rat oleic acid model of acute lung injury.
Trans sodium crocetinate is a novel drug, which has been shown previously to increase whole-body oxygen consumption during hemorrhagic shock. TSC has been suggested to work by increasing the diffusion rate of oxygen through plasma rather than on a specific symptom of hemorrhagic shock and has been suggested as a general treatment for hypoxemia. Thus, it might also be beneficial for treating respiratory insufficiencies. This study employed an oleic acid model of acute lung injury to determine if TSC could increase arterial PO2 in that model.
Gainer
J L
JL
Department of Chemical Engineering, University of Virginia, P.O. Box 400741, Charlottesville, VA 22904-4741, USA. jlg@virginia.edu
Stennett
A K
AK
Murray
R J
RJ
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002338:Carotenoids / Q000627:therapeutic use*; D008297:Male; D019301:Oleic Acid / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D014801:Vitamin A / Q000031:analogs & derivatives
D000975:Antioxidants; C487773:trans-sodium crocetinate; D014801:Vitamin A; D019301:Oleic Acid; D002338:Carotenoids