Prognostic factors in chronic obstructive pulmonary disease.
OBJECTIVE
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Its epidemiology has changed over the years and the key changes are a rising mortality rate and a greater incidence among women. Predicting survival time of patients with COPD is difficult. Reliable prognostic markers are useful and important information for patients, their families, and for the physician. The purpose of this review is to examine traditional and newer prognostic factors of COPD.


RESULTS
Loss of fat free mass (FFM), need and frequency of hospitalization for acute exacerbation, and symptom score are now recognized as important parameters to supplement the traditional prognostic markers of age, forced expiratory volume in 1 second (FEV1), hypoxemia, and hypercapnia.


CONCLUSIONS
A prognostic model based on office practice data now affords a means of more reliably predicting outcome for patients with COPD.
Dolan
Stephen
S
Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53295, USA. dolan@mcw.edu
Varkey
Basil
B
D003422:Critical Care; D004417:Dyspnea / Q000209:etiology; D017079:Exercise Tolerance; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D012720:Severity of Illness Index; D015431:Weight Loss