Transgenic chickens as bioreactors for protein-based drugs.
The potential of using transgenic animals for the synthesis of therapeutic proteins was suggested over twenty years ago. Considerable progress has been made in developing methods for the production of transgenic animals and specifically in the expression of therapeutic proteins in the mammary glands of cows, sheep and goats. Development of transgenic hens for protein production in eggs has lagged behind these systems. The positive features associated with the use of the chicken in terms of cost, speed of development of a production flock and potentially appropriate glycosylation of target proteins have led to significant advances in transgenic chicken models in the past few years.
Lillico
Simon G
SG
Roslin Institute, Roslin, Midlothian EH25 9PS, UK.
McGrew
Michael J
MJ
Sherman
Adrian
A
Sang
Helen M
HM
D000818:Animals; D030801:Animals, Genetically Modified; D019149:Bioreactors; D002645:Chickens / Q000235:genetics; D010063:Ovum / Q000378:metabolism; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics
D011506:Proteins; D011994:Recombinant Proteins