[Magnesium and ischemic heart disease].
From the epidemiological view point, chronic Mg intake deficiency could play a role of the onset of ischemic heart disease. Mg intake deficiency increases not only vaso-spasmobility of coronary artery, but also exacerbates several coronary risk factors such as hypertension, diabetes mellitus, and mental stress. We have previously reported that blood concentrations of Mg(2+) in patients with ischemic heart disease, especially acute coronary syndrome, was lower than that of healthy subjects. The lower blood concentrations of Mg(2+) may be a result of serious cardiac ischemia. According to the large-scale clinical trials, the efficacy of Mg administration to the patients with acute myocardial infarction has not been established, however, supplementary Mg may keep blood Mg(2+) level adequately and protect cardiac injury from cardiac ischemia.
Ueshima
Kenji
K
Memorial Heart Center, The Second Department of Internal Medicine.
D006801:Humans; D008274:Magnesium / Q000097:blood; D008275:Magnesium Deficiency / Q000150:complications*; D017202:Myocardial Ischemia / Q000097:blood / Q000209:etiology*
D008274:Magnesium