title: Human leukocyte antigen class II alleles in Caucasian women with primary biliary cirrhosis.
abstract: In the current study, we investigated human leukocyte antigen (HLA) class II alleles in Caucasian women with primary biliary cirrhosis (PBC), a disease that preferentially affects women. Alleles of DRB1, DQA1, and DQB1 were determined by DNA-based HLA typing for women with PBC (n = 72) and healthy women (n = 381). All study subjects were Caucasian. HLA DRB1*08 was significantly increased in women with PBC compared to healthy women. The increase was primarily due to the DRB1*0801 allele, also the most common DRB1*08 allele among controls. DQB1*04 and DQA1*0401 were significantly increased. DRB1*1501, DQA1*0102, and DQB1*0602 were associated with decreased risk. Analyses conducted comparing parous women with PBC to parous healthy women (n = 68 and n = 282, respectively) yielded similar significant results. Although the DRB1*08-DQA1*0401-DQB1*04 haplotype was significantly associated with PBC, consistent with other studies, this haplotype nevertheless represented only 19% (14/72) of all PBC patients and can account for only a minority of the risk of PBC.
authors.affiliation: Immunogenetics Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Mullarkey
authors.forename: A M
authors.initials: AM
authors.lastname: Stevens
authors.forename: W M
authors.initials: WM
authors.lastname: McDonnell
authors.forename: L S
authors.initials: LS
authors.lastname: Loubière
authors.forename: J A
authors.initials: JA
authors.lastname: Brackensick
authors.forename: J M
authors.initials: JM
authors.lastname: Pang
authors.forename: A J
authors.initials: AJ
authors.lastname: Porter
authors.forename: D A
authors.initials: DA
authors.lastname: Galloway
authors.forename: J L
authors.initials: JL
authors.lastname: Nelson
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000235:genetics* / Q000276:immunology; D008562:Membrane Glycoproteins / Q000235:genetics; D008875:Middle Aged; D012307:Risk Factors; D044465:White People
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II; D008562:Membrane Glycoproteins