A role for fucose alpha(1-2) galactose carbohydrates in neuronal growth.
We report a fucose alpha(1-2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucalpha(1-2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fucalpha(1-2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration.
Kalovidouris
Stacey A
SA
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Gama
Cristal I
CI
Lee
Lori W
LW
Hsieh-Wilson
Linda C
LC
D001710:Biotin / Q000737:chemistry; D004187:Disaccharides / Q000378:metabolism; D000939:Epitopes; D005643:Fucose / Q000378:metabolism / Q000502:physiology*; D005690:Galactose / Q000378:metabolism / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology; D006801:Humans; D037102:Lectins / Q000378:metabolism / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D011975:Receptors, Mitogen / Q000378:metabolism
D004187:Disaccharides; D000939:Epitopes; D037102:Lectins; D011975:Receptors, Mitogen; D005643:Fucose; D001710:Biotin; D005690:Galactose