SRC family kinases in cell volume regulation.
SRC family kinases are a group of nine cytoplasmic protein tyrosine kinases essential for many cell functions. Some appear to be ubiquitously expressed, whereas others are highly tissue specific. The ability of members of the SRC family to influence ion transport has been recognized for several years. Mounting evidence suggests a broad role for SRC family kinases in the cell response to both hypertonic and hypotonic stress, and in the ensuing regulatory volume increase or decrease. In addition, members of this tyrosine kinase family participate in the mechanotransduction that accompanies cell membrane deformation. Finally, at least one SRC family member operates in concert with the p38 MAPK to regulate tonicity-dependent gene transcription.
Cohen
David M
DM
Division of Nephrology, Mailcode PP262, Oregon Health and Science Univ. 3314 SW US Veterans Hospital Rd., Portland, OR 97239, USA. cohend@ohsu.edu
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D015220:Calcium Channels / Q000378:metabolism; D048429:Cell Size; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D007477:Ions / Q000378:metabolism; D009997:Osmotic Pressure; D015398:Signal Transduction / Q000502:physiology; D050052:TRPC Cation Channels; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism*
D015220:Calcium Channels; D007477:Ions; D050052:TRPC Cation Channels; D019061:src-Family Kinases; D048051:p38 Mitogen-Activated Protein Kinases