title: [Association of schizophrenia with a promoter polymorphism in the dopamine D2 receptor gene].
abstract: OBJECTIVE
  To investigate the association of -141C insert/delete polymorphism with schizophrenia in Wuhan of Hubei province.
  
  
  METHODS
  A case-control study was conducted to analyze the polymorphism in the D(2) receptor gene promoter region with schizophrenia. A total of 120 cases of schizophrenia diagnosed according to CCMD-II R criteria and 100 normal controls were recruited in the study.
  
  
  RESULTS
  In this sample, the allele and genotype showed statistically significant differences between patients and normal controls (P<0.05).Especially, the frequency of -141C del was 11% in patients and 18% in control(OR 0.55, 95% CI 0.30-0.96; P<0.05). This allele was less common in schizophrenia than in normal controls (P<0.05).
  
  
  CONCLUSIONS
  The -141C del polymorphism is associated with schizophrenia.The polymorphism may modify the association with other factors. Possibly -141C del in the DRD(2) promoter region is a strong candidate for a protective factor for this trait.
authors.affiliation: Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060 PR China. pengdaihui@21cn.com
authors.forename: Dai-hui
authors.initials: DH
authors.lastname: Peng
authors.forename: Gao-hua
authors.initials: GH
authors.lastname: Wang
authors.forename: Zi-li
authors.initials: ZL
authors.lastname: Cheng
authors.forename: De-xin
authors.initials: DX
authors.lastname: Zhang
authors.forename: Kai-da
authors.initials: KD
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics*
chemical_list: D017448:Receptors, Dopamine D2