A new and known cytotoxic aryltetralin-type lignans from stems of Bursera graveolens.
A new 4alpha-aryltetralin-type lignan called burseranin (1) and a known analogous lignan picropolygamain (2) were isolated along with known triterpenes, lupeol and epi-lupeol from the methanol extract of stems of Bursera graveolens, which showed a remarkable inhibitory activity against human HT1080 fibrosarcoma cells. The whole structure of 1 was established based on combined spectral studies and the absolute structure for 2 was first confirmed by CD spectral evidence. In addition, cytotoxic activities of the stem (methanol) extract and its components are evaluated in this paper.
Nakanishi
Tsutomu
T
Faculty of Pharmaceutical Sciences, Setsunan University, Osaka Japan. nakanisi@pharm.setsunan.ac.jp
Inatomi
Yuka
Y
Murata
Hiroko
H
Shigeta
Kaori
K
Iida
Naoki
N
Inada
Akira
A
Murata
Jin
J
Farrera
Miguel Angel Perez
MA
Iinuma
Munekazu
M
Tanaka
Toshiyuki
T
Tajima
Shogo
S
Oku
Naoto
N
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031233:Bursera / Q000737:chemistry*; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000737:chemistry*; D008800:Mexico; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013764:Tetrahydronaphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D010936:Plant Extracts; D013764:Tetrahydronaphthalenes; C500864:burseranin