Chromogranin A in pituitary adenomas: immunohistochemical detection and plasma concentrations.
Forty one pituitary adenomas excised surgically were immunostained to reveal pituitary hormones and chromogranin A (CgA). In 23 patients, plasma CgA concentration was determined before surgery by ELISA method. The CgA immunopositivity was found in 70.7% of investigated tumors. It was observed in all tumors of gonadotropinoma type and in the majority of null cell adenomas. Elevated (>18 U/L) plasma CgA concentration was observed in approx. a half of the examined patients, being more frequent in gonadotropinomas and null cell adenomas. It may have some, although limited, diagnostic value in these types of pituitary tumors.
Pawlikowski
Marek
M
Department of Experimental Endocrinology and Hormone Diagnostics, Medical University, Lódź, Poland. pawlikowski.m@wp.pl
Gruszka
Anna
A
Radek
Maciej
M
Kunert-Radek
Jolanta
J
D000236:Adenoma / Q000097:blood / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D053379:Chromogranin A; D002864:Chromogranins / Q000096:biosynthesis* / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology*
C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins