[Study on anti-bacterium activity of ginkgolic acids and their momomers].
OBJECTIVE
Ginkgolic acids and their three monomers were separated from ginkgo sarcotestas. The anti-bacterium activity of ginkgolic acids were tested. The relation between the anti-bacterium activity and side chain of ginkgolic acid were studied.


METHODS
The MIC of ginkgolic acids and their three monomers and salicylic acid were tested.


RESULTS
Ginkgolic acid has strong inhibitive effect on G+-bacterium. Salicylic acid has no side chain, so no anti-bacterial activity. When the length of gingkolic acid side chain is C13:0, it has the strongest anti-bacterial activity in three monomers.


CONCLUSIONS
The side chain of ginkgolic acid is the key functional group that possessed anti-bacterial activity. The length of Ginkgolic acid was the main effective factor of anti-bacterial activity.
Yang
Xiaoming
X
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013. zjyxm2003@hotmail.com
Zhu
Wei
W
Chen
Jun
J
Qian
Zhiyu
Z
Xie
Jimin
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D020441:Ginkgo biloba / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011425:Propionibacterium acnes / Q000187:drug effects*; D012459:Salicylates / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D012459:Salicylates; C112485:ginkgolic acid