title: [Utility of routine use of reversion after sedation in outpatient colonoscopy].
abstract: BACKGROUND
  Randomized clinical trials have demonstrated the effectiveness of flumazenil in reducing recovery time in the endoscopy unit after conscious sedation with midazolam and meperidine. However, its effectiveness in routine clinical practice has not been proved and therefore its use is debated.
  
  
  OBJECTIVE
  To determine the effectiveness of reversion with flumazenil after conscious sedation with midazolam and pethidine in outpatient colonoscopy and to evaluate its cost-effectiveness.
  
  
  METHODS
  Two hundred consecutive outpatients scheduled for colonoscopy with conscious sedation with midazolam and pethidine in 2 endoscopy units were prospectively included. According to routine clinical practice in each unit, 100 patients were reverted with flumazenil and 100 were not. Medical and demographic data, indications for endoscopy, doses of the medications used and endoscopic findings were collected. Three weeks after the colonoscopy each patient was interviewed by telephone to determine discomfort and complications associated with the endoscopy and/or with the use of sedation. The cost-effectiveness of the use of flumazenil was analyzed.
  
  
  RESULTS
  There were no differences between the two groups in age (52.9 +/- 15.5 vs 52.7 +/- 18.3, p = NS), indications for colonoscopy, findings, percentage of full colonoscopies (93 vs 95%; p = NS) or in the doses of sedatives used. The recovery time in each endoscopy unit was similar (19.2 +/- 11.7 vs 15.5 +/- 10.1 minutes, p = NS). In the reversion group there were fewer patients with prolonged stays, defined as those > 20 minutes (23 vs 11%, p < 0.001). The number of patients who remembered discomfort during the colonoscopy was significantly greater in the reversion group (23 vs 13%; p < 0.05). There were no differences in the number of patients who reported discomfort in the days following the endoscopy. The best cost-effectiveness ratio was obtained for a mean stay of 25 min.
  
  
  CONCLUSIONS
  Routine use of reversion does not decrease the mean stay in the endoscopy unit but does decrease the number of prolonged stays. Unpleasant memories of the colonoscopy were more frequent in reverted patients. The effectiveness of the routine use of reversion with flumazenil after conscious sedation with midazolam and pethidine depends on the ratio between the number of daily colonoscopies and the capacity of the recovery room.
authors.affiliation: Servicio de Aparato Digestivo, Red Hospiten Tenerife, Santa Cruz de Tenerife, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Alarcón Fernández
authors.forename: J S
authors.initials: JS
authors.lastname: Baudet Arteaga
authors.forename: A
authors.initials: A
authors.lastname: Sánchez del Río
authors.forename: M
authors.initials: M
authors.lastname: Moreno Sanfiel
authors.forename: J M
authors.initials: JM
authors.lastname: Martín Martín
authors.forename: P
authors.initials: P
authors.lastname: Borque Barrera
authors.forename: E
authors.initials: E
authors.lastname: Borja Gutiérrez
authors.forename: J
authors.initials: J
authors.lastname: Avilés Ruiz
mesh_terms: D000556:Ambulatory Surgical Procedures; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D003113:Colonoscopy / Q000379:methods; D016292:Procedural Sedation; D005260:Female; D005442:Flumazenil / Q000627:therapeutic use*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008614:Meperidine / Q000627:therapeutic use*; D008874:Midazolam / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives; D005442:Flumazenil; D008614:Meperidine; D008874:Midazolam