title: Auditory sensory gating deficit in abstinent chronic alcoholics.
abstract: P50 event-related potential was studied in abstinent chronic alcoholics to determine whether they had normal sensory gating. Repeated tones were presented to 17 recently detoxified chronic alcoholic patients and 17 healthy subjects while EEG was recorded. Low-resolution tomography (LORETA) was performed to obtain cerebral sources of P50. Abstinent chronic alcoholics showed reduced P50 sensory gating. Present results suggest an inhibitory deficit in early pre-attentive auditory sensory processing in chronic alcoholism.
authors.affiliation: Neurodynamics Laboratory, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Passeig de la Vall d'Hebron 171, 08035 Barcelona, Catalonia, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Marco
authors.forename: Lluís
authors.initials: L
authors.lastname: Fuentemilla
authors.forename: Carles
authors.initials: C
authors.lastname: Grau
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000437:Alcoholism / Q000503:physiopathology* / Q000523:psychology; D000704:Analysis of Variance; D001307:Auditory Perception / Q000502:physiology*; D001308:Auditory Perceptual Disorders / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D002908:Chronic Disease; D004569:Electroencephalography / Q000379:methods; D005072:Evoked Potentials, Auditory / Q000502:physiology; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors; D015898:Tomography Scanners, X-Ray Computed