Indocyanine green angiography anomalies in ocular syphilis.
OBJECTIVE
To report indocyanine green (ICG) angiography anomalies in ocular syphilis.


METHODS
A noncomparative, interventional case series.


METHODS
Eight patients (16 eyes) affected by ocular syphilis.


METHODS
All patients presenting with a diagnosis of active ocular syphilis between January 1994 and December 2001 were evaluated by a standard fluorescein and ICG angiography protocol. ICG angiography was repeated after completion of systemic antitreponemal and antiinflammatory treatment.


RESULTS
ICG angiography anomalies were detected in 12 (75%) of 16 eyes. Two types of anomalies were observed: late-phase scattered hyperfluorescent spots (11 eyes) and persistent staining of retinal vessels (1 eye). Of these 12 eyes, 4 had no alteration by concomitant fluorescein angiography. When ICG angiography was repeated (5 +/- 1 weeks after the beginning of treatment), ICG angiography anomalies disappeared.


CONCLUSIONS
ICG angiography may be a valuable tool in the assessment of patients with active ocular syphilis. Retinal and choroidal vascular anomalies can be determined that would otherwise go undetected by funduscopy and/or fluorescein angiography. It can also be useful in monitoring antitreponemal therapy.
Mora
Paolo
P
Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.
Borruat
François-Xavier
FX
Guex-Crosier
Yan
Y
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000993:Antitreponemal Agents / Q000627:therapeutic use; D004396:Coloring Agents; D015818:Eye Infections, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000627:therapeutic use; D012171:Retinal Vessels / Q000187:drug effects / Q000382:microbiology / Q000473:pathology*; D013587:Syphilis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D013588:Syphilis Serodiagnosis; D015866:Uveitis, Posterior / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D014792:Visual Acuity
D000900:Anti-Bacterial Agents; D000993:Antitreponemal Agents; D004396:Coloring Agents; D007208:Indocyanine Green; D010400:Penicillin G