ER retention of signaling modules.
A novel strategy for controlling developmental signaling pathways, which uses specific ER retention mechanisms, has emerged from several recent studies. A paper by Yamamoto et al. (2005) identifies a new protein termed Shisa that inhibits both Wnt- and FGF-signaling pathways during Xenopus gastrulation by mediating ER retention of the Wnt receptor Frizzled and the FGF receptor.
Schlesinger
Ayelet
A
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Shilo
Ben-Zion
BZ
D000818:Animals; D004721:Endoplasmic Reticulum / Q000502:physiology*; D051157:Frizzled Receptors; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D011506:Proteins / Q000502:physiology; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology; D015398:Signal Transduction; D051153:Wnt Proteins; D014981:Xenopus / Q000196:embryology / Q000502:physiology; D029867:Xenopus Proteins / Q000502:physiology
D051157:Frizzled Receptors; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D017468:Receptors, Fibroblast Growth Factor; D051153:Wnt Proteins; D029867:Xenopus Proteins