[Effects of Astragalus and saponins of Panax notoginseng on MMP-9 in patients with type 2 diabetic macroangiopathy].
OBJECTIVE
To investigate the role and mechanism of Astragalus (AS) and saponins of Panax notoginseng (PNS) in treating type 2 diabetic macroangiopathy.


METHODS
94 patients with type 2 diabetic macroangiopathy were divided into two groups randomly: group treated with Simvastatin and group treated with AS and PNS, compared with 40 healthy control subjects. Serum level of MMP-9 and lipid in patients and healthy subjects were measured before and after treatment.


RESULTS
The serum levels of MMP-9, TG, TC, LDL-C, VLDL-C in patients with type 2 diabetic macroangiopathy were improved, while the levels of HDL-C were decreased. Like Simvastatin AS and PNS had the function of reducing MMP-9 and accommodating lipid metabolism.


CONCLUSIONS
Besides accommodating lipid metabolism, AS and PNS can also reduce the level of serum MMP-9 soas to treat type 2 diabetic macroangiopathy.
Liu
Kuan-zhi
KZ
Department of Endocrinology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
Li
Jing-bo
JB
Lu
Hai-li
HL
Wen
Jin-kun
JK
Han
Mei
M
D000368:Aged; D027885:Astragalus propinquus / Q000737:chemistry; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D036145:Ginsenosides / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D005894:Panax / Q000737:chemistry; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D019821:Simvastatin / Q000627:therapeutic use*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D000960:Hypolipidemic Agents; D008055:Lipids; D019821:Simvastatin; D020780:Matrix Metalloproteinase 9