Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3F1 mice: Increased small intestinal crypt survival and prolongation of average time to animal death.
Radioprotective effects of a water-soluble extracts from cultured medium of Ganoderma lucidum (Rei-shi) mycelia (designed as MAK) and Agaricus blazei (Agaricus) against the shortening of survival time or the injury of crypt by X-irradiation were investigated in male B6C3F1 mice. MAK and Agaricus at three different doses were mixed into basal diet into biscuits at 5, 2.5 and 1.25% and administered from 1 week before irradiation. MAK (5% group) significantly prolonged animal survival as compared with basal diet group (control group) after 7 Gy of X-ray irradiation at a dose rate of 2 Gy min(-1). At doses of 8, 10 and 12 Gy X-irradiation at a dose rate of 4 Gy min(-1) MAK (5% group) significantly increased crypt survival as compared to other groups. These results suggest that MAK can act as a radioprotective agent.
Kubo
Nanami
N
Department of Health Science, Hiroshima Prefectural Women's University, Minami-ku, Hiroshima 734-8558, Japan.
Myojin
Yuki
Y
Shimamoto
Fumio
F
Kashimoto
Naoki
N
Kyo
Eikai
E
Kamiya
Kenji
K
Watanabe
Hiromitsu
H
D000364:Agaricus / Q000737:chemistry*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D007421:Intestine, Small / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D051379:Mice; D025282:Mycelium / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012038:Regeneration / Q000187:drug effects / Q000528:radiation effects; D020940:Reishi / Q000737:chemistry*; D012995:Solubility; D015996:Survival Rate; D013997:Time Factors; D014867:Water / Q000737:chemistry; D014965:X-Rays
D010936:Plant Extracts; D014867:Water