title: Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP.
abstract: The mGluR5 antagonist MPEP was used to study the role of mGluR5 in MPTP-induced injury of the nigrostriatal DA neurons. The findings indicate that acute blockade of mGluR5 may result in neuroprotective actions against MPTP neurotoxicity on nigral DA cell bodies and striatal DA terminals using stereological analysis of TH immunoreactivity and microdensitometry. Biochemical analysis showed no restoration of DA levels and metabolism indicating a maintained reduction of DA transmission.
authors.affiliation: Department of Human Physiology, School of Medicine, Boulevard Luis Pasteur, 32, University of Málaga, 29071 Málaga, Spain. Jose.Aguirre@uma.es
authors.forename: Jose A
authors.initials: JA
authors.lastname: Aguirre
authors.forename: Jan
authors.initials: J
authors.lastname: Kehr
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshitake
authors.forename: Fang-Ling
authors.initials: FL
authors.lastname: Liu
authors.forename: Alicia
authors.initials: A
authors.lastname: Rivera
authors.forename: Sergio
authors.initials: S
authors.lastname: Fernandez-Espinola
authors.forename: Beth
authors.initials: B
authors.lastname: Andbjer
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Leo
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Medhurst
authors.forename: Luigi F
authors.initials: LF
authors.lastname: Agnati
authors.forename: Kjell
authors.initials: K
authors.lastname: Fuxe
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D020267:MPTP Poisoning / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D017729:Presynaptic Terminals / Q000187:drug effects* / Q000378:metabolism; D011725:Pyridines / Q000008:administration & dosage*; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013378:Substantia Nigra / Q000187:drug effects* / Q000378:metabolism
chemical_list: C578935:GRM5 protein, human; C578936:Grm5 protein, mouse; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; C121465:6-methyl-2-(phenylethynyl)pyridine; D004298:Dopamine