The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice.
HTm4 is a member of a newly defined family of human and murine proteins, the MS4 (membrane-spanning four) protein group, which has a distinctive four-transmembrane structure. MS4 protein functions include roles as cell surface signaling receptors and intracellular adapter proteins. We have previously demonstrated that HTm4 regulates the function of the KAP phosphatase, a key regulator of cell cycle progression. In humans, the expression of HTm4 is largely restricted to cells of the hematopoietic lineage, possibly reflecting a causal role for this molecule in differentiation/proliferation of hematopoietic lineage cells. In this study, we show that, like the human homologue, murine HTm4 is also predominantly a hematopoietic protein with distinctive expression patterns in developing murine embryos and in adult animals. In addition, we observed that murine HTm4 is highly expressed in the developing and adult murine nervous system, suggesting a previously unrecognized role in central and peripheral nervous system development.
Kutok
Jeffery L
JL
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Yang
Xing
X
Folkerth
Rebecca D
RD
Imitola
Jaime
J
Raddassi
Khadir
K
Yano
Yoshihiko
Y
Salahuddin
Saira
S
Lawitts
Joel
J
Imboden
Hans
H
Chinami
Masanobu
M
Shirakawa
Taro
T
Turner
Helen
H
Khoury
Samia
S
Sayegh
Mohamed H
MH
Scadden
David
D
Adra
Chaker
C
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D004622:Embryo, Mammalian / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000737:chemistry; D006413:Hematopoietic System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D008565:Membrane Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D009474:Neurons / Q000737:chemistry; D011487:Protein Conformation; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism
D018797:Cell Cycle Proteins; C503440:HTm4 protein, mouse; D008565:Membrane Proteins; D012333:RNA, Messenger