title: Clinical trial of a noninvasive contact lens glucose sensor.
abstract: OBJECTIVE
  The purpose of the present study was to determine the effectiveness of a fluorescent contact lens glucose sensor in monitoring glucose in patients with diabetes.
  
  
  METHODS
  Under an institutional review board-approved protocol, five fasting patients with type II diabetes were given a challenge consisting of 75 mL of Sustacal (Thomson Micromedex, Greenwood, CO) by mouth. Contact lens fluorescence and venous blood glucose were measured over a 3-h period.
  
  
  RESULTS
  Contact lens fluorescence appeared to track blood glucose well. The fluorescent daily-wear disposable contact lenses were comfortable and were tolerated well, even in patients who had not previously worn contact lenses.
  
  
  CONCLUSIONS
  The contact lens glucose sensor shows promise as a home glucose monitor.
authors.affiliation: Department of Ophthalmology, Downstate Health Science Center, State University of New York, Brooklyn, New York 11203-2098, USA. WFMarch47@aol.com
authors.forename: Wayne F
authors.initials: WF
authors.lastname: March
authors.forename: Achim
authors.initials: A
authors.lastname: Mueller
authors.forename: Peter
authors.initials: P
authors.lastname: Herbrechtsmeier
mesh_terms: D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation / Q000379:methods; D003261:Contact Lenses; D005453:Fluorescence; D005947:Glucose / Q000032:analysis*; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods
chemical_list: D001786:Blood Glucose; D005947:Glucose