A new route to trihydroxamate-containing artificial siderophores and synthesis of a new fluorescent probe.
A fluorescent labelled artificial siderophore 1 was synthesized by coupling a 7-nitrobenz-2-oxa-1,3-diazole (NBD) derivative to the terminal amino group of a new trihydroxamate-containing amine 2, a ferrichrome-type siderophore that was obtained from tris(hydroxymethyl)aminomethane. Compound 1 was shown to be a suitable tool for experiments on siderophore transport and uptake processes in various organisms cells and particularly in Candida albicans cells.
Ouchetto
H
H
Chimie, Ingénierie Moléculaire et Matériaux d'Angers, UMR 6200 du CNRS, 2 Boulevard Lavoisier, 49045 Angers Cedex, France.
Dias
M
M
Mornet
R
R
Lesuisse
E
E
Camadro
J-M
JM
D005291:Ferrichrome / Q000138:chemical synthesis* / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000737:chemistry*; D007502:Iron Chelating Agents / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D017262:Siderophores / Q000737:chemistry*
D005456:Fluorescent Dyes; D006877:Hydroxamic Acids; D007502:Iron Chelating Agents; D017262:Siderophores; D005291:Ferrichrome