title: Relationship between intracranial granulomas and cerebrospinal fluid levels of gamma interferon and interleukin-10 in patients with tuberculous meningitis.
abstract: Cerebrospinal fluid gamma interferon (IFN-gamma) and interleukin-10 levels in 39 patients with tuberculous meningitis were serially measured. Cytokine levels did not predict intracranial granuloma (IG) development, but IFN-gamma levels in the top quartile after 1 month of therapy were highly associated (odds ratio = 18) with detection of an IG by computed tomography scanning.
authors.affiliation: University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors.forename: Adel M
authors.initials: AM
authors.lastname: Mansour
authors.forename: Robert W
authors.initials: RW
authors.lastname: Frenck
authors.forename: Toni
authors.initials: T
authors.lastname: Darville
authors.forename: Isabelle A
authors.initials: IA
authors.lastname: Nakhla
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Wierzba
authors.forename: Yehia
authors.initials: Y
authors.lastname: Sultan
authors.forename: Magdy I
authors.initials: MI
authors.lastname: Bassiouny
authors.forename: Kathryn
authors.initials: K
authors.lastname: McCarthy
authors.forename: Richard F
authors.initials: RF
authors.lastname: Jacobs
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006099:Granuloma / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000134:cerebrospinal fluid*; D016753:Interleukin-10 / Q000134:cerebrospinal fluid*; D008297:Male; D011379:Prognosis; D016862:Tuberculoma, Intracranial / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D014390:Tuberculosis, Meningeal / Q000276:immunology*
chemical_list: D016753:Interleukin-10; D007371:Interferon-gamma