Transferrin: structure, function and potential therapeutic actions.
There are many proteins that can multi-task. Transferrin, widely known as an iron-binding protein, is one such example of a multi-tasking protein. In this review, the multiple biological actions of transferrin, including its growth and cytoprotective activities, are discussed with the view of highlighting the potential therapeutic applications of this protein.
Gomme
Peter T
PT
Research and Development, CSL Ltd., Bioplasma Division, 189-209 Camp Road, Broadmeadows, Victoria 3047, Australia. Peter.Gomme@csl.com.au
McCann
Karl B
KB
Bertolini
Joseph
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001692:Biological Transport; D016026:Bone Marrow Transplantation; D002318:Cardiovascular Diseases / Q000188:drug therapy; D006801:Humans; D007501:Iron / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy; D011878:Radiotherapy; D011990:Receptors, Transferrin / Q000502:physiology; D014168:Transferrin / Q000737:chemistry* / Q000502:physiology* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011990:Receptors, Transferrin; D014168:Transferrin; D007501:Iron