title: Higher graft salvage rate in renal allograft rupture associated with acute tubular necrosis.
abstract: BACKGROUND
  Renal allograft rupture is an early postoperative complication threatening graft and patient survival. We reviewed the etiology and prognostic factors for renal allograft rupture.
  
  
  METHODS
  Among 657 renal transplants performed between 1990 and 2001, renal allograft rupture was diagnosed in 10 cases. Statistical analysis by Student t test, ANOVA, and chi-square was performed to assess donor and recipient characteristics. Multivariate logistic regression to predict renal allograft rupture used variables with P <.15 in the univariate analysis.
  
  
  RESULTS
  Patients with renal allograft rupture were mainly men and young. Renal allograft rupture incidence was higher among allografts from non-heart-beating donors, kidneys with delayed graft function, or patients with a high antibody titer. Histopathological findings revealed that six renal allograft ruptures were secondary to acute rejection, three to acute tubular rejection and one to allograft infarction. Only one of six renal allograft ruptures (17.7%) secondary to rejection was resolved by surgery; two of the three patients (66.7%) with acute tubular necrosis were successfully operated and a nephrectomy was performed for the patient with allograft infarction. By multivariate logistic regression analysis, factors shown to be predictive for renal allograft rupture were: delayed graft function, age of recipient, peak panel-reactive antibody >25%, and initial immunosuppressive treatment without antithymocyte globulin.
  
  
  CONCLUSIONS
  Higher graft salvage rates are possible in cases of graft rupture associated with acute tubular necrosis.
authors.affiliation: Hospital de Alarcos, Departament of Nefrology, Ciudad Real, Spain. sanchezdelanieta@senefro.org
authors.forename: M D Garcia
authors.initials: MD
authors.lastname: Sanchez de la Nieta
authors.forename: A I
authors.initials: AI
authors.lastname: Sánchez-Fructuoso
authors.forename: R
authors.initials: R
authors.lastname: Alcázar
authors.forename: M J
authors.initials: MJ
authors.lastname: Pérez-Contin
authors.forename: D
authors.initials: D
authors.lastname: Prats
authors.forename: J
authors.initials: J
authors.lastname: Grimalt
authors.forename: J
authors.initials: J
authors.lastname: Blanco
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000097:blood; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology*; D008297:Male; D011183:Postoperative Complications / Q000628:therapy*; D012189:Retrospective Studies; D012421:Rupture; D016879:Salvage Therapy / Q000379:methods*; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000473:pathology
chemical_list: D007518:Isoantibodies