title: [Clostridium infections in leukemias and malignant neoplasms].
abstract: This review describes the subject of clostridial complications in leukemia and malignant neoplasms. These complications include bacteremia and spontaneous nontraumatic gas gangrene of the muscles. The mechanism of anaerobic microenvironment formation, which is necessary for infection development in neoplastic tumors, is also demonstrated. The role of risk factors contributing to the occurrence of clostridial infections is discussed. Further, the etiology of infections, related mostly to the action of Clostridium septicum and Clostridium perfringens toxins, as well as the pathogenesis of complications and their clinical course are indicated. Present treatment strategies are also briefly described.
authors.affiliation: II Katedra i Klinika Chirurgii Ogólnej Akademii Medycznej w Lublinie. wallner@panaceum.am.lublin.pl
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Wallner
authors.forename: Paweł
authors.initials: P
authors.lastname: Misiuna
authors.forename: Wiesław
authors.initials: W
authors.lastname: Cygan
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Cygan
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003015:Clostridium Infections / Q000209:etiology* / Q000382:microbiology / Q000503:physiopathology; D003016:Clostridium perfringens; D005738:Gas Gangrene / Q000209:etiology; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000503:physiopathology; D009369:Neoplasms / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents