[Preparation of stearic acid solid lipid nanoparticles containing podophyllotoxin].
OBJECTIVE
To improve the therapeutic efficacy and reduce the adverse effect of podophyllotoxin (PPT) by wrapping it in stearic acid solid lipid nanoparticles.


METHODS
Stearic acid solid lipid nanoparticles containing podophyllotoxin was prepared using modified microemulsion technique, whose morphology was examined by transmission electron microscope. High-performance of liquid chromatography was employed to determine the entrapment efficiency of PPT in the nanoparticles.


RESULTS
The entrapment efficiency of PPT in the nanoparticles was 85.6% and the mean diameter of the particles was 56.5+/-25.8 nm.


CONCLUSIONS
The stearic acid solid lipid nanoparticles has high entrapment efficiency for PPT and is homogeneous in size, which can be a promising targeted preparation for epidermal delivery.
Xie
Fang-ming
FM
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zeng
Kang
K
Li
Guo-feng
GF
Lin
Zhong-fang
ZF
Sun
Le-dong
LD
D003218:Condylomata Acuminata / Q000188:drug therapy; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004355:Drug Stability; D008055:Lipids; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D011034:Podophyllotoxin / Q000008:administration & dosage*; D013229:Stearic Acids / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods
D004337:Drug Carriers; D008055:Lipids; D013229:Stearic Acids; C031183:stearic acid; D011034:Podophyllotoxin