DNA ligase: getting a grip to seal the deal.
The crystal structure of human DNA ligase I catches the enzyme just before the last step of ligation and shows that the protein wraps completely around nicked DNA. The elegant structure explains how ligase attains fidelity for the sealing operation.
Johnson
Aaron
A
The Rockefeller University 1230 York Avenue, Box 228, New York, New York 10021-6399, USA. johnsoa@mail.rockefeller.edu
O'Donnell
Mike
M
D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000737:chemistry*; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D018809:Proliferating Cell Nuclear Antigen / Q000737:chemistry; D011487:Protein Conformation; D017434:Protein Structure, Tertiary
D004268:DNA-Binding Proteins; C000607892:LIG1 protein, human; D018809:Proliferating Cell Nuclear Antigen; D011088:DNA Ligases; D000072481:DNA Ligase ATP