Design and synthesis of a new class of arginine analogues with an improved anion binding site in the side chain.
Replacing the guanidinium group in arginine (1) by a guanidiniocarbonyl pyrrole moiety provides a new class of artificial amino acids (2), that can be used as building blocks in standard solid phase peptide synthesis.
Schmuck
Carsten
C
Institut für Organische Chemie, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany. schmuck@chemie.uni-wuerzburg.de
Geiger
Lars
L
D000838:Anions / Q000737:chemistry*; D001120:Arginine / Q000031:analogs & derivatives / Q000737:chemistry*; D001665:Binding Sites; D015195:Drug Design; D019791:Guanidine / Q000031:analogs & derivatives* / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry
D000838:Anions; D011758:Pyrroles; D001120:Arginine; D019791:Guanidine