[Effects of MSF on melanocyte adhesion and migration in vitro].
OBJECTIVE
To investigate the Malytea Scurfpea fruit (MSF) on melanocyte adhesion and migration.


METHODS
Human epidermal melanocytes were treated with MSF and Ginger respectively, then adhesion to bovine serum fibronectin-coated culture dishes was checked. Control and treated cells were also examined for migration into micropore filters coated with the same protein.


RESULTS
Compared with control, MSF treated melanocytes were obviously easier to adhere to the dishes and move into the filters in a dose-dependent manner. When the dose of MSF was 200 mg x L(-1), it could not reincrease melanocyte adhesion and migration. At 10 mg x L(-1), under every other concentrations of MSF, there was no marked difference among MSF-treated, Ginger-treated and untreated melanocytes (P < 0.05) when adhesion test were studied. But to migration, even at 10 mg x L(-1) MSF, there was obvious increased migration compared with MSF-untreated or Ginger-treated melanocytes (P < 0.01).


CONCLUSIONS
MSF has effect on melanocyte adhesion and migration, which can explain, in part, the capacity of MSF to modulate melanocyte function in vitiligo lesions.
Mou
Kuan-hou
KH
Department of Dermatology, First Hospital of Xi' an Jiaotong University, Xi' an 710061, China. moukuanhou@sohu.com
Zhang
Xian-qi
XQ
Yu
Bing
B
Zhou
Ai-ming
AM
Feng
Jie
J
D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D020939:Zingiber officinale / Q000737:chemistry; D006801:Humans; D008544:Melanocytes / Q000166:cytology / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry; D029907:Psoralea / Q000737:chemistry
D004365:Drugs, Chinese Herbal