title: Effect of catechins on mutagenesis of Salmonella typhimurium TA 102 elicited by tert-butyl hydroperoxide (t-BuOOH).
abstract: Green tea, one of the most popular beverages consumed in Asian countries, has been reported to possess anticarcinogenic and antimutagenic properties. The aim in this study is to test the radical scavenging effect of catechins and caffeine, which were major components of green tea, and if they really prevent oxygen radical-induced mutagenesis. We used TA102 strain of Salmonella typhimurium which is sensitive to hydroxyl radical in the Ames mutation assay. We found that caffeine did not show any effects on mutagenesis in this system, but catechin significantly reduced mutagenesis or genotoxicity caused by hydroxyl radical. This radical-scavenging action of catechins may indeed contribute to the anticarcinogenic activity of green tea as has been proposed.
authors.affiliation: Laboratory of Toxicology, Department of Environmental Veterinary Sciences, School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nikaidou
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ishizuka
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Maeda
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Hara
authors.forename: Akio
authors.initials: A
authors.lastname: Kazusaka
authors.forename: Shoichi
authors.initials: S
authors.lastname: Fujita
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D017665:Hydroxyl Radical; D008297:Male; D009152:Mutagenicity Tests; D051381:Rats; D017208:Rats, Wistar; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics*; D013662:Tea; D020122:tert-Butylhydroperoxide / Q000037:antagonists & inhibitors / Q000633:toxicity
chemical_list: D016587:Antimutagenic Agents; D016166:Free Radical Scavengers; D013662:Tea; D017665:Hydroxyl Radical; D002110:Caffeine; D002392:Catechin; D020122:tert-Butylhydroperoxide