title: [Expanding the possibilities of using biphosphonates for prophylaxis and treatment of osteal complications in malignant metastasis].
abstract: New results concerning the mechanisms of biphosphonate action on malignant metastasis are described, which justify an increase in the use of biphosphonates not only for the treatment of malignancies, but for prophylaxis of malignant neoplasm development as well. Data on the relationship between the pharmacological effect of biphosphonates and their chemical structure are presented. It is emphasized that clodronate, which is most thoroughly investigated drug of this group, can be more frequently used in clinics for the treatment and prophylaxis of osteal complications in cases of breast cancer.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Svishchenko
authors.forename: N L
authors.initials: NL
authors.lastname: Shimanovskiĭ
mesh_terms: D000818:Animals; D000963:Antimetabolites / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000517:prevention & control* / Q000556:secondary; D001943:Breast Neoplasms / Q000150:complications*; D004002:Clodronic Acid / Q000627:therapeutic use*; D004164:Diphosphonates; D005260:Female; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000517:prevention & control
chemical_list: D000963:Antimetabolites; D004164:Diphosphonates; D004002:Clodronic Acid