title: A novel mechanism for connecting bacterial two-component signal-transduction systems.
abstract: Bacteria have many two-component signal-transduction systems (TCSs) that respond to specific environmental signals by altering the phosphorylated state of a response regulator. Although these systems are presumed to form an intricate signal network, the detailed mechanism of how they interact with each other remains largely unexplained. In a recent study of Salmonella, two TCSs have been discovered to be connected by a protein that protects a response regulator from dephosphorylation promoted by its cognate sensor kinase. This novel mechanism might provide an answer to some of the linkages found between other TCSs.
authors.affiliation: Department of Bioscience and Biotechnology, Graduate School of Agriculture of Kinki University, 3327-204 Nakamachi, Nara 631-8505, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Eguchi
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Utsumi
mesh_terms: D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000502:physiology; D004926:Escherichia coli / Q000235:genetics / Q000502:physiology; D029968:Escherichia coli Proteins / Q000502:physiology; D025461:Feedback, Physiological / Q000502:physiology; D015964:Gene Expression Regulation, Bacterial; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000502:physiology; D010749:Phosphoprotein Phosphatases / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology; D019779:Salmonella enterica / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; C065601:BvgA protein, Bacteria; D029968:Escherichia coli Proteins; C465223:EvgS protein, E coli; D009097:Multienzyme Complexes; C079792:PhoQ protein, Bacteria; C409039:PmrB protein, bacteria; C087732:PmrD protein, Salmonella; C489568:RcsB protein, E coli; D014157:Transcription Factors; C081902:pmrA protein, Bacteria; C489728:rcsC protein, E coli; C061064:PhoP protein, Bacteria; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases