title: Laser therapy on arthritis induced by urate crystals.
abstract: OBJECTIVE
  We aimed to evaluate low-power laser therapy efficacy on fibrinogen (PF) in the plasma of rats with arthritis induced by urate crystals. In addition, anatomopathological (AP) studies were carried out.
  
  
  BACKGROUND
  Raised blood uric acid may form microscopic crystals in the joint. These crystals set up the inflammation called "acute gouty arthritis."
  
  
  METHODS
  Two mg of uric acid were injected in both joints of the lower limbs of rats over 2 days. A group was treated with He-Ne laser (6 mW) on the injected joints during 3 consecutive days. After 96 h of the first injection, animals were sacrificed to determine fibrinogen by spectrophotometry. Sections from the lower limbs were used for AP studies.
  
  
  RESULTS
  A statistically significant increase (p < 0.001) in plasma fibrinogen levels was observed in the group injected with urates, when compared to both control group and the laser-treated group. The AP observed in the untreated group showed an intense fibroblastic proliferation and chronic inflammation. In the group treated with laser no inflammatory reaction was observed.
  
  
  CONCLUSIONS
  Laser therapy has an anti-inflammatory effect in arthropathy induced in rats injected with urates, determined by fibrinogen levels and by histological involution.
authors.affiliation: Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa, Córdoba, Argentina. campanav@hotmail.com
authors.forename: Vilma R
authors.initials: VR
authors.lastname: Campana
authors.forename: Mónica
authors.initials: M
authors.lastname: Moya
authors.forename: Antonio
authors.initials: A
authors.lastname: Gavotto
authors.forename: Luis
authors.initials: L
authors.lastname: Spitale
authors.forename: Fernando
authors.initials: F
authors.lastname: Soriano
authors.forename: José A
authors.initials: JA
authors.lastname: Palma
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D001168:Arthritis / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D053685:Laser Therapy; D051381:Rats; D014527:Uric Acid / Q000009:adverse effects
chemical_list: D014527:Uric Acid; D005340:Fibrinogen