[Mechanisms of respiratory system lesions in chemical plant workers of the environmental protection department in comparison with workers of pesticide producing departments].
In chemical plant workers producing pesticides chronic bronchitis and disturbed pulmonary ventilation are frequent. The aim of the examination of the staff (sewage-treatment plant, waste combustion plant, waste storage, industrial water pumping station)--16 males aged 21-53 years--was to assess: 1. Connective tissue metabolism--serum concentration of type I and III procollagen propeptides, collagen I telopeptide, hydroxyproline, alpha1-AP and alpha2-M antiproteases, interstitial collagenase (MMP-1) activity, as well as urine hydroxyproline and desmosine. 2. Free radical damage--serum malonic dialdehyde (TBARS) and ceruloplasmin concentration, erythrocyte antioxidant enzymes activity (SOD, catalase, GPx, GR), and neutrophils myeloperoxidase reaction. 3. Humoral (serum IgG, A and M, C3 complement component and the circulating immune complexes) and cellular (percentage of CD3, CD4 and CD8 lymphocytes) immunity rates. As compared to controls the following changes were found: 1. decreased MMP-1 activity and increased alpha2-M serum concentration; 2. increased erythrocyte SOD and GPx activities; 3. decreased percentage of T lymphocytes (CD3), increased serum concentration of the C3 complement component and the circulating immune complexes. The results were compared with those in workers of the departments producing liquid pesticides, dust pesticides and chlorfenvinphose, the changes of the investigated parameters were found to be less expressed.
Kossmann
Stefan
S
Klinika Chorób Wewnetrznych i Farmakologii Klinicznej, Slaskiej Akademii Medycznej w Katowicach.
Friedek
Daniela
D
Grabowska-Bochenek
Rozalia
R
Kłuciński
Piotr
P
Konieczny
Bogusław
B
Kopieczna-Grzebieniak
Ewa
E
Kotrys-Puchalska
Elzbieta
E
Piskorska
Danuta
D
Sobczak
Andrzej
A
Tustanowski
Jerzy
J
D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D000917:Antibody Formation / Q000187:drug effects; D016022:Case-Control Studies; D002617:Chemical Industry; D003238:Connective Tissue / Q000187:drug effects / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007106:Immune Sera / Q000378:metabolism; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000276:immunology / Q000378:metabolism*; D010575:Pesticides / Q000009:adverse effects*; D011044:Poland; D012140:Respiratory Tract Diseases / Q000139:chemically induced* / Q000276:immunology / Q000378:metabolism*; D012307:Risk Factors
D000395:Air Pollutants, Occupational; D005609:Free Radicals; D007106:Immune Sera; D010575:Pesticides