title: A laboratory simulation for morselized bone graft fusion: apparent modulus under operatively based femoral impaction kinetics.
abstract: The purpose of this study was to determine the apparent modulus changes accompanying a novel procedure for simulating in situ fusion of morselized cancellous bone femoral impaction grafts. An experienced surgeon's habitual intra-operative impaction grafting protocol was first quantified in human cadaver femurs, using a customized impulse force hammer. A corresponding standardized impaction procedure was then defined, and was used to prepare impaction grafts in axisymmetric metallic fixturing designed to replicate the nominal geometry of femoral canal confinement. Impaction graft fusion was simulated by mixing morselized cancellous bone with an amine-based epoxy adhesive before the impaction, then allowing the mixture to fuse after the impaction (J. Biomech. 34 (2001) 811). Force/deflection behavior of the unfused and fused impaction grafts was measured for both the (tapered) proximal and (untapered) distal portions of the grafts. Apparent modulus was then calculated from force/deflection stiffness. The impaction graft fusion simulation increased apparent modulus by an order of magnitude over the unfused state, for mixture parameters appropriate to have the fused graft apparent modulus be comparable to the compressive modulus of intact femoral cancellous bone.
authors.affiliation: Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA. anneliese-heiner@uiowa.edu
authors.forename: Anneliese D
authors.initials: AD
authors.lastname: Heiner
authors.forename: John J
authors.initials: JJ
authors.lastname: Callaghan
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Brown
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000379:methods*; D001696:Biomechanical Phenomena; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D005269:Femur / Q000601:surgery*; D006801:Humans; D008422:Materials Testing; D008954:Models, Biological; D010316:Particle Size
chemical_list: D018786:Bone Substitutes