title: Tumour on the tricuspid valve: metastatic osteosarcoma and the heart.
abstract: The antemortem diagnosis of cardiac metastases in osteogenic sarcoma has been documented in only 25 cases over the past 50 years, whereas a prevalence as high as 20% is seen at autopsy, suggesting that cardiac involvement is a late stage complication. As the survival times for primary osteosarcoma continue to improve, previously rare, late stage complications will undoubtedly become more prevalent. In addition to presenting a new case of cardiac metastasis with prolonged survival, the present case report reviews the 25 cases from the literature to illustrate the distinguishing characteristics and clinical presentation, as well as to draw conclusions regarding investigation and management. The demographic differences include female sex, advanced age at the time of diagnosis and longer interval to onset of secondary disease. The clinical characteristics involve hemodynamic compromise or precordial abnormality, with magnetic resonance imaging emerging as the gold standard for diagnosis. Cardiac involvement is a strong predictor of disease elsewhere and mandates careful surveillance, with surgical management likely providing the best outcome.
authors.affiliation: University of Alberta, Edmonton, Canada.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Platonov
authors.forename: A Robert
authors.initials: AR
authors.lastname: Turner
authors.forename: John C
authors.initials: JC
authors.lastname: Mullen
authors.forename: Michelle
authors.initials: M
authors.lastname: Noga
authors.forename: Robert C
authors.initials: RC
authors.lastname: Welsh
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000473:pathology* / Q000628:therapy; D006348:Cardiac Surgical Procedures / Q000379:methods; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D006801:Humans; D012516:Osteosarcoma / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D010027:Osteotomy / Q000379:methods; D018570:Risk Assessment; D012540:Scapula; D016896:Treatment Outcome