Limited slowdown of endocrine-disruptor diffusion in confined fluid lipid membranes.
Self-diffusion rates of lipids and trapped bisphenol A (BPA) are determined in various sizes of confined but fluid membranes by high-field-gradient NMR at 600 MHz. Micelles and vesicles of 3- to 400-nm diameters are used as model membranes to get an insight into the molecular diffusion in such soft environments. The slowdown of BPA and lipid motions is leveled off in 100- and 400-nm vesicles, although the hydrodynamic continuum model gives the aggregate motion slowed inversely to the aggregate size. Instead, the limited motion is related to the intra-membrane fluidity.
Okamura
Emiko
E
Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. emiko@scl.kyoto-u.ac.jp
Wakai
Chihiro
C
Matubayasi
Nobuyuki
N
Sugiura
Yukio
Y
Nakahara
Masaru
M
D001559:Benzhydryl Compounds; D004058:Diffusion; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism; D008567:Membranes, Artificial; D008823:Micelles; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D010636:Phenols / Q000737:chemistry* / Q000493:pharmacokinetics; D010713:Phosphatidylcholines / Q000737:chemistry; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D008563:Membrane Lipids; D008567:Membranes, Artificial; D008823:Micelles; D010636:Phenols; D010713:Phosphatidylcholines; C017251:1,2-oleoylphosphatidylcholine; C006780:bisphenol A; D000098826:Bisphenol A Compounds