title: [Delta-opioid receptor agonists prevent the irreversible damage of cardiomyocytes in ischemized-reperfused isolated rat heart].
abstract: Pretreatment with selective delta-opioid receptor (delta-OR) agonists decreased the level of creatine kinase in the coronary effluent of isolated rat heart during a 45-min global ischemia and a 30-min reperfusion. The effect was completely abolished after pretreatment of the delta-OR antagonist nitrindole. At the same time, pretreatment with mu-OR antagonists did not affect the level of creatine kinase in the coronary effluent. It is suggested that stimulation of the cardiac delta-OR prevents the irreversible cardiac cell damage during global ischemia and reperfusion in vitro. In contrast, the cardiac mu-OR do not play any significant role in regulation of the cardiac resistance to the pathogenic action of ischemia and reperfusion.
authors.forename: A A
authors.initials: AA
authors.lastname: Platonov
authors.forename: T V
authors.initials: TV
authors.lastname: Lasukova
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: J M
authors.initials: JM
authors.lastname: Downey
authors.forename: H
authors.initials: H
authors.lastname: Nagaze
authors.forename: M V
authors.initials: MV
authors.lastname: Ovchinnikov
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000503:physiopathology*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000819:agonists*
chemical_list: D000700:Analgesics; D017465:Receptors, Opioid, delta