Gastrointestinal lesions and Helicobacter pylori in patients with myeloproliferative disorders.
OBJECTIVE
The aim of this study is to investigate the endoscopic lesions, and Helicobacter pylori (H. pylori) positivity in patients with myeloproliferative disorders (MPD).


METHODS
Thirty patients with MPD and 93 controls with functional dyspepsia were enrolled in this study after informed consent obtained between March 2000 and July 2003. The study was held at the Departments of Hematology and Gastroenterology, Adnan Menderes University Faculty of Medicine, Adnan, Turkey. Physical examination, hemogram, peripheral blood examination, upper endoscopic examinations were performed in all patients. Helicobacter pylori positivity was evaluated by rapid urease test, and by histopathological examination of the biopsies obtained from antrum and corpus.


RESULTS
The H. pylori positivity was 46.7% in MPD and 19.4% in control group (p<0.05). The prevalence of gastritis was much higher in MPD patients than control group (p<0.05). There was no gastrointestinal bleeding in control group but 8 patients in MPD group (26.7%; p<0.05).


CONCLUSIONS
The higher susceptibility of H. pylori infection and high frequency of gastric lesions in patients with MPD suggests a surveillance of these patients. The eradication of H. pylori to avoid probable gastrointestinal problems is advised in MPD patients.
Karaoglu
Ali O
AO
Gastroenterology Department, Adnan Menderes University Faculty of Medicine, 09100, Aydin, Turkey. yukselenvahit@yahoo.com
Kadikoylu
Gurhan
G
Yukselen
Vahit
V
Yasa
Mehmet H
MH
Bolaman
Zahit
Z
D000328:Adult; D000368:Aged; D001706:Biopsy; D015897:Comorbidity; D003430:Cross-Sectional Studies; D004198:Disease Susceptibility; D016099:Endoscopy, Gastrointestinal; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000453:epidemiology; D004941:Esophagitis / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000175:diagnosis / Q000453:epidemiology*; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000453:epidemiology; D016481:Helicobacter Infections / Q000175:diagnosis / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000453:epidemiology*; D010437:Peptic Ulcer / Q000175:diagnosis / Q000453:epidemiology*; D012016:Reference Values; D013223:Statistics as Topic; D013922:Thrombocytosis / Q000175:diagnosis / Q000453:epidemiology; D014421:Turkey