title: Coronary artery disease alters ventricular repolarization dynamics in type 2 diabetes.
abstract: Ventricular repolarization dynamics (VRD) is an important predictor of outcome in diabetes. We examined the potential impact of coronary artery disease (CAD) on VRD in type 2 diabetic patients. We recorded 5-minute high-resolution resting electrocardiograms in 38 diabetic patients undergoing elective coronary angiography, and in 38 age- and gender-matched apparently healthy subjects (controls). Using leads-I and -II, time-domain indices of VRD were calculated. Coronary angiography was regarded as positive if >/= 50% stenosis was found. Angiography was positive in 21 diabetic patients (55%). Patients with CAD had a significantly higher degree of VRD than controls (SDNN(QT): 15.81 +/- 7.22 ms versus 8.94 +/- 6.04 ms; P < 0.001, rMSSD(QT): 21.02 +/- 7.07 ms versus 11.18 +/- 7.45 ms; P < 0.001). Ventricular repolarization dynamics in diabetic patients with negative angiograms did not differ from VRD in controls (SDNN(QT): 8.94 +/- 6.04 ms versus 7.44 +/- 5.72 ms; P = 0.67, rMSSD(QT): 11.18 +/- 7.45 ms versus 10.22 +/- 5.35 ms; P = 0.82). CAD increases VRD in patients with type 2 diabetes. Therefore, changes in ventricular repolarization in diabetic patients may be due to silent CAD rather than due to diabetes per se.
authors.affiliation: Division of Cardiology, Ljubljana University Medical Center, Ljubljana, Slovenia. bojan.vrtovec@mf.uni-lj.si
authors.forename: Bojan
authors.initials: B
authors.lastname: Vrtovec
authors.forename: Matjaz
authors.initials: M
authors.lastname: Sinkovec
authors.forename: Vito
authors.initials: V
authors.lastname: Starc
authors.forename: Branislav
authors.initials: B
authors.lastname: Radovancevic
authors.forename: Todd T
authors.initials: TT
authors.lastname: Schlegel
mesh_terms: D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D004311:Double-Blind Method; D004594:Electrophysiology; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged