title: Quantitative evaluation and modeling of two-dimensional neovascular network complexity: the surface fractal dimension.
abstract: BACKGROUND
  Modeling the complex development and growth of tumor angiogenesis using mathematics and biological data is a burgeoning area of cancer research. Architectural complexity is the main feature of every anatomical system, including organs, tissues, cells and sub-cellular entities. The vascular system is a complex network whose geometrical characteristics cannot be properly defined using the principles of Euclidean geometry, which is only capable of interpreting regular and smooth objects that are almost impossible to find in Nature. However, fractal geometry is a more powerful means of quantifying the spatial complexity of real objects.
  
  
  METHODS
  This paper introduces the surface fractal dimension (Ds) as a numerical index of the two-dimensional (2-D) geometrical complexity of tumor vascular networks, and their behavior during computer-simulated changes in vessel density and distribution.
  
  
  RESULTS
  We show that Ds significantly depends on the number of vessels and their pattern of distribution. This demonstrates that the quantitative evaluation of the 2-D geometrical complexity of tumor vascular systems can be useful not only to measure its complex architecture, but also to model its development and growth.
  
  
  CONCLUSIONS
  Studying the fractal properties of neovascularity induces reflections upon the real significance of the complex form of branched anatomical structures, in an attempt to define more appropriate methods of describing them quantitatively. This knowledge can be used to predict the aggressiveness of malignant tumors and design compounds that can halt the process of angiogenesis and influence tumor growth.
authors.affiliation: Scientific Direction, Istituto Clinico Humanitas, Via Manzoni 56-20089 Rozzano, Milan, Italy. fabio.grizzi@humanitas.it
authors.forename: Fabio
authors.initials: F
authors.lastname: Grizzi
authors.forename: Carlo
authors.initials: C
authors.lastname: Russo
authors.forename: Piergiuseppe
authors.initials: P
authors.lastname: Colombo
authors.forename: Barbara
authors.initials: B
authors.lastname: Franceschini
authors.forename: Eldo E
authors.initials: EE
authors.lastname: Frezza
authors.forename: Everardo
authors.initials: E
authors.lastname: Cobos
authors.forename: Maurizio
authors.initials: M
authors.lastname: Chiriva-Internati
mesh_terms: D003198:Computer Simulation; D017709:Fractals; D008955:Models, Cardiovascular; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000473:pathology*; D017711:Nonlinear Dynamics