title: Phenotype-first screening for the identification of novel drug targets.
abstract: Modern drug discovery is predominantly a target-driven process, where success is intricately linked to the selection of an appropriate molecular target. Ideally, there is conclusive functional evidence that a selected target is disease-relevant and, furthermore, suitable for drug development. Phenotype-first screening is a highly attractive approach for target identification because it offers the unique possibility to analyse entire genomes in an unbiased fashion for disease-related phenotypes. Various studies have demonstrated that phenotype-first screening can be successfully applied to the identification of drug targets, thus establishing this approach as a valuable tool for future target discovery efforts.
authors.affiliation: DeveloGen AG, Rudolf-Wissell-Strasse 28, 37079 Göttingen, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Austen
authors.forename: Cord
authors.initials: C
authors.lastname: Dohrmann
mesh_terms: D000818:Animals; D015195:Drug Design; D020869:Gene Expression Profiling; D016678:Genome; D023281:Genomics / Q000379:methods; D006801:Humans; D023421:Models, Animal; D009154:Mutation; D010641:Phenotype