Effect of early initiation of statins on survival in patients with acute myocardial infarction (the USIC 2000 Registry).
We evaluated the association of statin initiation within 48 hours of admission for an acute myocardial infarction with a 1-year prognosis on a nationwide scale. Patients who received a statin within 48 hours of admission but not before hospitalization had an improved prognosis (hazard ratio 0.57, 95% confidence interval 0.38 to 0.86, p <0.007) after adjustment for covariates and propensity score.
Ferrières
Jean
J
Department of Epidemiology, INSERM U558, Toulouse, France. jean.ferrieres@cict.fr
Cambou
Jean-Pierre
JP
Guéret
Pascal
P
Boutalbi
Youcef
Y
Lablanche
Jean-Marc
JM
Hanania
Guy
G
Genès
Nathalie
N
Cantet
Christelle
C
Danchin
Nicolas
N
D000368:Aged; D005260:Female; D005602:France / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality*; D011379:Prognosis; D016016:Proportional Hazards Models; D012042:Registries; D013997:Time Factors
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors