Investigation of obesity candidate genes on porcine fat deposition quantitative trait loci regions.
OBJECTIVE
To investigate possible obesity candidate genes in regions of porcine quantitative trait loci (QTL) for fat deposition and obesity-related phenotypes.


METHODS
Chromosome mapping and QTL analyses of obesity candidate genes were performed using DNA panels from a reference pig family. Statistical association analyses of these genes were performed for fat deposition phenotypes in several other commercial pig populations.


RESULTS
Eight candidate genes were mapped to QTL regions of pig chromosomes in this study. These candidate genes also served as anchor loci to determine homologous human chromosomal locations of pig fat deposition QTL. Preliminary analyses of relationships among polymorphisms of individual candidate genes and a variety of phenotypic measurements in a large number of pigs were performed. On the basis of available data, gene-gene interactions were also studied.


CONCLUSIONS
Comparative analysis of obesity-related genes in the pig is not only important for development of marker-assisted selection on growth and fat deposition traits in the pig but also provides for an understanding of their genetic roles in the development of human obesity.
Kim
Kwan-Suk
KS
Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011-3150, USA.
Thomsen
Hauke
H
Bastiaansen
John
J
Nguyen
Nguyet Thu
NT
Dekkers
Jack C M
JC
Plastow
Graham S
GS
Rothschild
Max F
MF
D000273:Adipose Tissue; D054366:Agouti Signaling Protein; D054369:Agouti-Related Protein; D000818:Animals; D002874:Chromosome Mapping; D008040:Genetic Linkage; D005838:Genotype; D054439:Ghrelin; D024003:HMGA Proteins / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D009765:Obesity / Q000235:genetics / Q000662:veterinary*; D047495:PPAR gamma; D036361:Peptide Hormones / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics; D040641:Quantitative Trait Loci / Q000235:genetics*; D044104:Receptor, Melanocortin, Type 3 / Q000235:genetics; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics; D013552:Swine / Q000235:genetics; D013553:Swine Diseases / Q000235:genetics*
D054366:Agouti Signaling Protein; D054369:Agouti-Related Protein; D054439:Ghrelin; D024003:HMGA Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047495:PPAR gamma; D036361:Peptide Hormones; D011506:Proteins; D044104:Receptor, Melanocortin, Type 3; D044105:Receptor, Melanocortin, Type 4