title: New antiproliferative benzoindolinothiazepines derivatives.
abstract: New benzoindolinothiazepines containing a piperazine moiety are described as potent antiproliferative agents against PC3 human prostatic cell lines. This activity could be explained by an accumulation of cells in G1 phase.
authors.affiliation: Institut de chimie pharmaceutique Albert Lespagnol, universite de Lille 2, EA 2692, 3, rue du Professeur Laguesse, B.P. 83, 59006 Lille cedex, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Laconde
authors.forename: Patrick
authors.initials: P
authors.lastname: Depreux
authors.forename: Pascal
authors.initials: P
authors.lastname: Berthelot
authors.forename: Nicole
authors.initials: N
authors.lastname: Pommery
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Hénichart
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D016193:G1 Phase / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008297:Male; D008956:Models, Chemical; D011471:Prostatic Neoplasms / Q000378:metabolism; D013841:Thiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013841:Thiazepines