title: Efficacy and safety of an olive oil-based intravenous fat emulsion in adult patients on home parenteral nutrition.
abstract: BACKGROUND
  The most frequently used intravenous lipid emulsions are composed of 100% long chain triacylglycerols from soybean oil or of 50% long chain triacylglycerols-50% medium chain triacylglycerols. A newer emulsion, ClinOleic 20% containing 80% olive oil and 20% soybean oil, was suggested to reduce lipid peroxidation and immune function impairment.
  
  
  OBJECTIVE
  To assess ClinOleic 20%'s efficacy, safety and effect upon systemic inflammatory parameters in adults on home parenteral nutrition.
  
  
  METHODS
  In stable home parenteral nutrition patients, the initial intravenous lipid emulsion was changed for ClinOleic 20%. Nutritional status, clinical and biological tolerance, and systemic inflammatory markers were analysed before and after 1 and 3 months of home parenteral nutrition, with ClinOleic 20% as intravenous lipid emulsion.
  
  
  RESULTS
  Clinical and biological nutritional markers and inflammatory parameters did not differ between day 0 and month +3. There was no essential fatty acids deficiency. No side-effects were reported. Three of five patients presenting with migraine during home parenteral nutrition infusion at day 0 felt consistently better at month +3.
  
  
  CONCLUSIONS
  ClinOleic 20% is safe and efficient in adult home parenteral nutrition. It maintains normal essential fatty acids status and did not influence inflammatory parameters. In contrast to studies in preterm infants or paediatric patients, no effect on vitamin E concentration or lipid peroxidation was observed.
authors.affiliation: Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, Centre Agréé de Nutrition Parentérale à Domicile, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre, Avenue Molière, Strasbourg Cedex, France. jean-marie.reimund@wanadoo.fr
authors.forename: J-M
authors.initials: JM
authors.lastname: Reimund
authors.forename: G
authors.initials: G
authors.lastname: Rahmi
authors.forename: G
authors.initials: G
authors.lastname: Escalin
authors.forename: G
authors.initials: G
authors.lastname: Pinna
authors.forename: G
authors.initials: G
authors.lastname: Finck
authors.forename: C D
authors.initials: CD
authors.lastname: Muller
authors.forename: B
authors.initials: B
authors.lastname: Duclos
authors.forename: R
authors.initials: R
authors.lastname: Baumann
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004751:Enteritis / Q000628:therapy; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007415:Intestinal Obstruction / Q000628:therapy; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D016331:Parenteral Nutrition, Home / Q000009:adverse effects / Q000379:methods*; D010938:Plant Oils / Q000009:adverse effects / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000628:therapy; D012778:Short Bowel Syndrome / Q000628:therapy; D016896:Treatment Outcome; D014815:Vitamins / Q000097:blood
chemical_list: D005217:Fat Emulsions, Intravenous; D018836:Inflammation Mediators; D008055:Lipids; D000069463:Olive Oil; D010938:Plant Oils; D014815:Vitamins