title: A hybrid between the antifungal azole eberconazole and the alkaloid onychine.
abstract: The 9-imidazolylazafluorene 3, a hybrid between the antifungal azole eberconazole and the alkaloid onychine, was prepared from onychine in two steps. This product shows moderate antifungal activity, but, in contrast to other azoles, is not an inhibitor of ergosterol biosynthesis.
authors.affiliation: Department Pharmazie - Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Dombeck
authors.forename: F
authors.initials: F
authors.lastname: Bracher
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003508:Cycloheptanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D044950:Flavanones; D005658:Fungi / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011728:Pyridones; D013055:Spectrophotometry, Infrared
chemical_list: D000470:Alkaloids; D000935:Antifungal Agents; D003508:Cycloheptanes; D044950:Flavanones; D007093:Imidazoles; D007202:Indicators and Reagents; D011728:Pyridones; C054955:onychine; C118963:eberconazole