Photodynamic and photo-cross-linking potential of bergamottin.
Bergamottin (5-geranoxypsoralen) is a main component of bergamot and grapefruit oil. In order to investigate the photophysical and photochemical behaviour of bergamottin, absorption and fluorescence properties, production of singlet oxygen and superoxide radical anions and further cross-linking of DNA were studied. Strong photochemical reactions were not observed.
Bode
C W
CW
Institute of Pharmacy, Department of Pharmaceutical Chemistry, Christian-Albrechts-University Kiel, Germany.
Zager
A
A
Hänsel
W
W
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004247:DNA / Q000737:chemistry / Q000187:drug effects; D005363:Ficusin / Q000737:chemistry; D011564:Furocoumarins / Q000737:chemistry* / Q000528:radiation effects*; D010777:Photochemistry; D017382:Reactive Oxygen Species / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013481:Superoxides / Q000737:chemistry
D003432:Cross-Linking Reagents; D011564:Furocoumarins; D017382:Reactive Oxygen Species; D013481:Superoxides; D004247:DNA; C068337:bergamottin; D005363:Ficusin