title: Soluble platelet glycoprotein V is a marker of thrombosis in patients with ischemic stroke.
abstract: OBJECTIVE
  The diagnosis and management of patients with acute ischemic stroke still lack an informative biochemical test. Soluble glycoprotein V (sGPV) is a new plasmatic marker of thrombosis released from the platelet surface by thrombin. The objective of this prospective study was to compare the levels of sGPV in stroke and control patients.
  
  
  METHODS
  Consecutive patients with acute ischemic stroke (n=159) and controls (n=70) were recruited for sGPV measurement.
  
  
  RESULTS
  Plasmatic levels of sGPV were significantly increased in ischemic stroke compared with control patients (median [interquartile range] 39.4 [31.8 to 52.9] versus 28.1 [24.0 to 37.9] ng/mL; P<0.0001). In multivariate analysis, ischemic stroke was the major determinant of the sGPV increase (odds ratio [95% CI], 5.87 [2.62 to 13.12]; P<0.0001).
  
  
  CONCLUSIONS
  sGPV is a new marker of arterial thrombosis and represents a tool to study the mechanisms involved in ischemic stroke. The increase in plasmatic sGPV observed in stroke patients supports a role of platelets and thrombin in the events leading to ischemic stroke.
authors.affiliation: Etablissement Français du Sang-Alsace, Strasbourg, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Wolff
authors.forename: Boris
authors.initials: B
authors.lastname: Aleil
authors.forename: Maurice
authors.initials: M
authors.lastname: Giroud
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Lorenzini
authors.forename: Nicolas
authors.initials: N
authors.lastname: Meyer
authors.forename: Marie-Louise
authors.initials: ML
authors.lastname: Wiesel
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Cazenave
authors.forename: François
authors.initials: F
authors.lastname: Lanza
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood*; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012995:Solubility; D020521:Stroke / Q000097:blood*; D013927:Thrombosis / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D019038:Platelet Glycoprotein GPIb-IX Complex