[Prevention and treatment of chronic atrophic gastritis in rats with isinglass].
OBJECTIVE
To evaluate the effect of isinglass on the prevention and treatment of chronic atrophic gastritis in rats.


METHODS
Animal model of SD rats with CAG was established in accordance with the previous experience of combined administration of 60% ethanol, 20 mmol x L(-1) sodium deoxycholate and 0.1% ammonia water. In prevention groups, sucralfate and isinglass were used as preventive therapy while we were establishing CAG rat model. In the reverse groups, sucralfate and isinglass were used to treat rats after establishment of CAG rat model. Finally all the rats were executed and pathologic changes of the gastric mucosa were studied by gross appearance and microscopy.


RESULTS
In isinglass prevention groups and reverse groups, inflammation grades of gastric antrum were less than these in model control group (P < 0.01) while the means of ratios of the thickness of gastric mucosal gland and muscularis mucos (L1/L2), the number of gastric glands in 1-mm lengths of mucosal layer were much better than those in model control group (P < 0.01). They were very close to normal control group (P > 0.05).


CONCLUSIONS
Isinglass can prevent the gastric mucosal atrophy in the CAG model and can improve and cure the gastric mucosal atrophy of the SD rats with GAG.
Xu
Miao
M
Gastroenterologic Laboratory of Clinical Institute, Sir Run Run Shaw Hospital Affiliated to Medical School of Zhejiang University, Hangzhou 310016, China.
Si
Jian-min
JM
Wang
Liang-jing
LJ
Wang
Hai-yun
HY
Wu
Jia-guo
JG
Cao
Qian
Q
D000818:Animals; D002908:Chronic Disease; D005753:Gastric Mucosa / Q000473:pathology; D005757:Gastritis, Atrophic / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*; D005780:Gelatin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D008419:Materia Medica; D005780:Gelatin; C005123:isinglass