title: [Pharmacokinetics of beta-asarone in rats].
abstract: OBJECTIVE
  To study the pharmacokinetics of beta-asarone in rats.
  
  
  METHODS
  The concentration of beta-asarone in serum and organs were measured by HPLC after i.g. administration, the pharmacokinetics was analyzed with DAS software regarding the organs as independent system.
  
  
  RESULTS
  The pharmacokinetics of beta-asarone can be described as first order process of one-compartment model. In the serum, T(1/2), Tpeak and Cmax were 54 min, 12 min and 3.19 mg x L(-1), respectively. The procedure in the organs was similar to that in serum.
  
  
  CONCLUSIONS
  The absorption, distribution and elimination of beta-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of beta-asarone.
authors.affiliation: First Affiliated Hospital of Guangzhou University of TCM, Guangzhou 510405, China. benzwoo3000@163.com
authors.forename: Hong-bin
authors.initials: HB
authors.lastname: Wu
authors.forename: Yong-qi
authors.initials: YQ
authors.lastname: Fang
mesh_terms: D029023:Acorus / Q000737:chemistry; D000284:Administration, Oral; D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D006207:Half-Life; D008297:Male; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; C012195:asarone