[Perfluorine (perftoran) influence on lipid peroxidation and salivary antioxidant activity in patients with periodontal disease].
As it was shown in the clinical study local use of perftoran in patients with periodontal disease led to significant reduction of lipid peroxidation (LPO) and significant increase of antioxidant activity (AOA) in saliva. The most prominent effect was observed in patients with medium or severe degree of the disease. The data allowed to speak about perftorane influence upon tissue respiration processes, that was confirmed by the corresponding changes in LPO and AOA. The proved ability of perftorane to oxygen transportation increased oxygen delivery to the tissues around parodontal pockets, that improves local metabolism, normalizes breathing (respiration) cycle, has the influence upon anaerobic microflora. As the result of local perftorane use a decrease of active forms of oxygen was registered.
Grudianov
A I
AI
Chupakhin
P V
PV
D000287:Administration, Topical; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D005466:Fluorocarbons / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D010518:Periodontitis / Q000188:drug therapy / Q000378:metabolism*; D010519:Periodontium / Q000187:drug effects / Q000378:metabolism; D012463:Saliva / Q000187:drug effects / Q000378:metabolism*
D000975:Antioxidants; D005466:Fluorocarbons; C063334:perftoran; D010100:Oxygen