Function and regulation of cullin-RING ubiquitin ligases.
Cullin-RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin-RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin-RING ligases, and describe how these enzymes can be characterized by a set of general principles.
Petroski
Matthew D
MD
Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA. petroski@caltech.edu deshaies@caltech.edu
Deshaies
Raymond J
RJ
D000818:Animals; D044842:Cullin Proteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D017434:Protein Structure, Tertiary; D025801:Ubiquitin / Q000502:physiology; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry / Q000502:physiology*
D044842:Cullin Proteins; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases