title: Pachyelasides A-D, novel molluscicidal triterpene saponins from Pachyelasma tessmannii.
abstract: This is the first report for secondary metabolites in an African medicinal plant, Pachyelasma tessmannii (Leguminosae). Four novel saponins, pachyelasides A-D, were isolated from the methanol extract of the root bark by using recycling HPLC. These compounds showed molluscicidal activity (LD(50) < or =8.0 mug/mL) against the South American snail, Biomphalaria glabratus. The structures were determined on the basis of extensive nuclear magnetic resonance spectroscopic and matrix-assisted laser desorption/ionization time-of-flight mass spectrometric studies.
authors.affiliation: Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, USA.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Nihei
authors.forename: Bai-Ping
authors.initials: BP
authors.lastname: Ying
authors.forename: Takanori
authors.initials: T
authors.lastname: Murakami
authors.forename: Hiroko
authors.initials: H
authors.lastname: Matsuda
authors.forename: Masaru
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Isao
authors.initials: I
authors.lastname: Kubo
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000187:drug effects*; D007887:Fabaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C497775:pachyelaside A; C497774:pachyelaside B; C497776:pachyelaside C; C497777:pachyelaside D