Seroprevalence of Helicobacter pylori in Chinese patients on continuous ambulatory peritoneal dialysis.
OBJECTIVE
There is relatively little data on the seroprevalence of Helicobacter pylori in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). This study aims at establishing the seroprevalence of and the factors associated with H. pylori infection in Chinese CAPD patients.


METHODS
All CAPD patients from a single dialysis centre were invited to participate in the study. Diagnosis of H. pylori infection was made serologically by the pylori DTect ELISA method. Dyspeptic symptoms were assessed by the Hong Kong Index of Dyspepsia (HKID) Questionnaire. Demographic, clinical and laboratory parameters were correlated with the H. pylori serology results.


RESULTS
One hundred and thirty-six Chinese CAPD patients were included in the study. The mean age of the patients was 61.8 +/- 12.5 years with a male to female ratio of 1:1.4. The mean duration of CAPD was 54 +/- 42 months. Thirty-five patients (26%) have positive serology against H. pylori. Nineteen patients had a HKID score of >16. There was no association between H. pylori seropositivity and dyspeptic symptoms (P = 0.62). Patients who were seropositive for H. pylori were significantly older (64.9 +/- 9.5 years vs 60.7 +/- 13.2 years, P < 0.05) and had lower KT/V-values than patients who were seronegative for H. pylori (1.88 +/- 0.3 vs 2.03 +/- 0.3, P < 0.05). Patients with positive or negative H. pylori serological status did not differ in terms of demographic parameters (e.g. sex, duration of CAPD), clinical factors (e.g. bodyweight, body mass index, hepatitis status, use of H(2) antagonists or proton pump inhibitors) and laboratory data (e.g. haemoglobin, serum urea, creatinine, albumin and parathyroid hormone levels).


CONCLUSIONS
The seroprevalence of H. pylori infection among Chinese CAPD patients is 26%. Helicobacter pylori seropositivity is not associated with dyspepsia. Older age and lower KT/V-values appear to be associated with the development of H. pylori seropositivity in our dialysis population.
Lui
Sing Leung
SL
Division of Nephrology, University Department of Medicine, Tung Wah Hospital, 12, Po Yan Street, Sheung Wan, Hong Kong SAR, China. sllui@hku.hk
Wong
Wai Man
WM
Ng
Suk Yi
SY
Chan
Tak Mao
TM
Lai
Kar Neng
KN
Lo
Wai Kei
WK
D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D044466:Asian People / Q000706:statistics & numerical data; D004415:Dyspepsia / Q000453:epidemiology; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000706:statistics & numerical data*; D016036:Seroepidemiologic Studies
D000907:Antibodies, Bacterial