The role of NK1.1+ cells in the protection against MHC class I+ HPV16-associated tumours.
Depletion of NK1.1+ cells by repeated i.p. injections of PK136 antibody significantly enhanced growth of MHC class I+ tumours in syngeneic mice. Depletion starting before tumour transplantation or on the day of transplantation substantially accelerated tumour growth; depletion starting on day 7 or 14 after tumour transplantation was without any effect. These results indicate that the NK1.1+ cells play an important inhibitory role during the early phase of the growth of some MHC class I+ tumours. Since the relevant target for NK cells is a "missing self" signal, absence of the MHC class I molecules, the NK cells cannot be expected to directly inhibit the growth of the MHC class I+ tumours. The results indicate that the effects of non-NK cells or indirect effects mediated by NK cell interactions and release of cytokines were responsible for the results.
Símová
J
J
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Bubeník
J
J
Bieblová
J
J
Jandlová
T
T
D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D045744:Cell Line, Tumor; D015395:Histocompatibility Antigens Class I / Q000032:analysis* / Q000235:genetics; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008212:Lymphocyte Depletion; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009856:Oncogene Proteins, Viral / Q000235:genetics; D030361:Papillomavirus Infections / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control; D012097:Repressor Proteins / Q000235:genetics
D000906:Antibodies; C068651:E6 protein, Human papillomavirus type 16; D015395:Histocompatibility Antigens Class I; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins; C062495:oncogene protein E7, Human papillomavirus type 6