DNA repair: the importance of phosphorylating histone H2AX.
How phosphorylated histone H2AX, known as gamma-H2AX, functions in the cellular response to DNA double-strand breaks is the subject of intensive investigation. Recent research in yeast and mammalian cells shows that gamma-H2AX facilitates post-replicational DNA repair by recruiting cohesin, a protein complex that holds sister chromatids together.
Lowndes
Noel F
NF
Genome Stability Laboratory, Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland.
Toh
Geraldine W-L
GW
D000818:Animals; D018797:Cell Cycle Proteins; D002842:Chromatids / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone; D004260:DNA Repair; D005656:Fungal Proteins; D006657:Histones / Q000378:metabolism*; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism; D010766:Phosphorylation; D011995:Recombination, Genetic / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D005656:Fungal Proteins; D006657:Histones; D009687:Nuclear Proteins; D000097722:Cohesins; C475961:gamma-H2AX protein, mouse