title: The effect of sustained heavy exercise on the development of pulmonary edema in trained male cyclists.
abstract: To determine whether intense, prolonged activity can induce transient pulmonary edema, eight highly trained male cyclists (mean +/- S.D.: age, 26.9 +/- 3.0 years; height, 179.9 +/- 5.7 cm; weight, 76.1 +/- 6.5 kg) performed a 45-min endurance cycle test (ECT). V(O2,max) was determined (4.84 +/- 0.4 L min(-1), 63.7 +/- 2.6 ml min(-1) g(-1)) and the intensity of exercise for the ECT was set at 10% below ventilatory threshold (approximately 76% V(O2, max) 300 +/- 25 W). Pre- and post-exercise pulmonary diffusion (DL(CO)) measurements and magnetic resonance imaging of the lung were made. DL(CO) and pulmonary capillary blood volume (VC) decreased 1h post-exercise by 12% (P = 0.004) and 21% (P = 0.017), respectively, but no significant change in membrane diffusing capacity (DM) was found. The magnetic resonance scans demonstrated a 9.4% increase (P = 0.043) in pulmonary extravascular water 90 min post-exercise. These data support the theory that high intensity, sustained exercise in well-trained athletes can result in transient pulmonary edema.
authors.affiliation: Allan McGavin Sports Medicine Centre and School of Human Kinetics, The University of British Columbia, 3055 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3. kari@interchange.ubc.ca
authors.forename: D C
authors.initials: DC
authors.lastname: McKenzie
authors.forename: T J
authors.initials: TJ
authors.lastname: O'Hare
authors.forename: J
authors.initials: J
authors.lastname: Mayo
mesh_terms: D000328:Adult; D001642:Bicycling / Q000293:injuries*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D010807:Physical Endurance / Q000502:physiology*; D011653:Pulmonary Diffusing Capacity / Q000502:physiology; D011654:Pulmonary Edema / Q000473:pathology / Q000503:physiopathology*; D011659:Pulmonary Gas Exchange; D012129:Respiratory Function Tests / Q000379:methods; D014692:Ventilation-Perfusion Ratio