title: Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors.
abstract: A new series of pyrazolidine derivatives was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). Compound 9i was the most active in this series, exhibited IC50 value of 1.56 microM and ED50 value of 80 mg/kg (in vivo DP-IV inhibition; po).
authors.affiliation: Medicinal Science Division, Korea Research Institute of Chemical Technology, Taejon 305-600, Republic of Korea. jhahn@krict.re.kr
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Ahn
authors.forename: Jin Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Hye-Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Hyuk-Man
authors.initials: HM
authors.lastname: Kwon
authors.forename: Sun-Chul
authors.initials: SC
authors.lastname: Huh
authors.forename: Sang Dal
authors.initials: SD
authors.lastname: Rhee
authors.forename: Kwang Rok
authors.initials: KR
authors.lastname: Kim
authors.forename: Sung-Don
authors.initials: SD
authors.lastname: Yang
authors.forename: Sung-Dae
authors.initials: SD
authors.lastname: Park
authors.forename: Jae Mok
authors.initials: JM
authors.lastname: Lee
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Hyae Gyeong
authors.initials: HG
authors.lastname: Cheon
mesh_terms: D018819:Dipeptidyl Peptidase 4 / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D011720:Pyrazoles; D018819:Dipeptidyl Peptidase 4