title: 1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.
abstract: 1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described.
authors.affiliation: Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA. sompong.wattanasin@pharma.novartis.com
authors.forename: Sompong
authors.initials: S
authors.lastname: Wattanasin
authors.forename: Joerg
authors.initials: J
authors.lastname: Kallen
authors.forename: Stewart
authors.initials: S
authors.lastname: Myers
authors.forename: Qin
authors.initials: Q
authors.lastname: Guo
authors.forename: Michael
authors.initials: M
authors.lastname: Sabio
authors.forename: Claus
authors.initials: C
authors.lastname: Ehrhardt
authors.forename: Rainer
authors.initials: R
authors.lastname: Albert
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hommel
authors.forename: Gisbert
authors.initials: G
authors.lastname: Weckbecker
authors.forename: Karl
authors.initials: K
authors.lastname: Welzenbach
authors.forename: Gabriele
authors.initials: G
authors.lastname: Weitz-Schmidt
mesh_terms: D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000187:drug effects* / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D007659:Ketones; D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1