Antifungal activity of posaconazole compared with fluconazole and amphotericin B against yeasts from oropharyngeal candidiasis and other infections.
OBJECTIVE
The in vitro antifungal activity of posaconazole was compared with that of fluconazole and amphotericin B.


METHODS
A microdilution method (M27-A2) was used with 331 clinical yeast isolates.


RESULTS
The geometric mean MICs of posaconazole, fluconazole and amphotericin B were 0.16, 0.91 and 0.15 mg/L, respectively. Posaconazole was markedly more active than fluconazole and was active against 9/11 fluconazole-resistant Candida albicans, and five Candida glabrata had an MIC of posaconazole of 16 mg/L.


CONCLUSIONS
These data indicate that posaconazole is a potentially effective antifungal agent for the treatment of mycoses caused by yeasts.
Carrillo-Muñoz
Alfonso-Javier
AJ
Departamento de Microbiología, ACIA, PO Box 10178, E-08080 Barcelona. acarrillo@ya.com
Quindós
Guillermo
G
Ruesga
Maite
M
Alonso
Rocío
R
del Valle
Oscar
O
Hernández-Molina
Juan Manuel
JM
McNicholas
Paul
P
Loebenberg
David
D
Santos
Patricia
P
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002180:Candidiasis, Oral / Q000382:microbiology*; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D014230:Triazoles / Q000494:pharmacology*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B; D015725:Fluconazole