Rheumatoid disease and the heart: from epidemiology to echocardiography.
Rheumatoid disease (RD) is a common chronic inflammatory condition associated with progressive joint destruction. Sufferers of RD experience reduced life expectancy, reflected in the increased standardised mortality rates reported in several studies over the last 50 years. Most studies indicate that the increased mortality affecting this population is mainly due to cardio-vascular disease. Epidemiological data have revealed an increased risk of developing ischaemic heart disease and heart failure in RD. The increased risk of ischaemic heart disease may result from traditional risk factors but data suggest that RD may confer risk independently. Although pericardial involvement, valvopathy and myocarditis are the most well-recognised cardiac manifestations of RD, and constitute a rheumatoid heart disease, these features are relatively benign. The current prevalence of rheumatoid heart disease in the era of early administration of disease-modifying therapy requires evaluation.
Bhatia
Gurbir S
GS
University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK.
Sosin
Michael D
MD
Grindulis
Karl A
KA
Davis
Russell C
RC
Lip
Gregory Y H
GY
D001172:Arthritis, Rheumatoid / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D004452:Echocardiography / Q000706:statistics & numerical data; D006321:Heart; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015995:Prevalence; D012214:Rheumatic Heart Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000209:etiology