title: Mouse and guinea pig models for testing new tuberculosis vaccines.
abstract: Animal models of pulmonary tuberculosis in the mouse and guinea pig contain to provide new information about the host response in the lungs, changes in immunopathology, and the protective effect of new vaccine candidates. These include Mtb72F, a polyprotein vaccine that gives excellent protection and also boosts and prolongs the protective effect of the BCG vaccine.
authors.affiliation: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA. iorme@lamar.colostate.edu
authors.forename: Ian M
authors.initials: IM
authors.lastname: Orme
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000276:immunology / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000276:immunology* / Q000627:therapeutic use; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D023421:Models, Animal; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D032581:Tuberculosis Vaccines / Q000276:immunology / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*
chemical_list: D001500:BCG Vaccine; D001426:Bacterial Proteins; D032581:Tuberculosis Vaccines