title: Orthogonal multipolar interactions in structural chemistry and biology.
abstract: The past few decades of molecular recognition studies have greatly enhanced our knowledge on apolar, ion-dipole, and hydrogen-bonding interactions. However, much less attention has been given to the role that multipolar interactions, in particular those with orthogonal dipolar alignment, play in organizing a crystal lattice or stabilizing complexes involving biological receptors. By using results from database mining, this review attempts to give an overview of types and structural features of these previously rather overlooked interactions. A number of illustrative examples of these interactions found in X-ray crystal structures of small molecules and protein-ligand complexes demonstrate their propensity and thus potential importance for both, chemical and biological molecular recognition processes.
authors.affiliation: Laboratorium für Organische Chemie, ETH-Hönggerberg, HCI, 8093 Zürich, Switzerland.
authors.forename: Ralph
authors.initials: R
authors.lastname: Paulini
authors.forename: Klaus
authors.initials: K
authors.lastname: Müller
authors.forename: François
authors.initials: F
authors.lastname: Diederich
mesh_terms: D001695:Biology; D003460:Crystallization; D018360:Crystallography, X-Ray; D030562:Databases, Protein; D008024:Ligands; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D011506:Proteins