title: [Indications for automatic implantable defibrillators in patients with the Brugada syndrome].
abstract: Brugada syndrome is a primary electrical cardiac disease characterized by an ST segment elevation in V1-V2 leads on surface ECG and an increased risk of polymorphic ventricular tachyarrhythmia (ventricular tachycardia and/or ventricular fibrillation). The objective of the treatment is to prevent sudden death and it therefore includes in some cases the implantation of an automatic implantable cardiac defibrillator (AICD). In secondary prevention (i.e. after a first episode of resuscitated ventricular fibrillation), the implantation of AICD is mandatory (indication of class 1 level A). In primary prevention (i.e. in patients without documented ventricular fibrillation), the guidelines are not definitively established. We may consider two different clinical situations. First, the patient complains from syncope and this justifies the implantation of an AICD. Second, the patient is asymptomatic and the physician has to discuss the implantation of an AICD. Two parameters should be analysed: the pattern of ECG and the result of right programmed ventricular stimulation. An evident ST segment elevation (>2 mm) is associated with a high risk of sudden death. Likewise, the inducibility of a ventricular tachycardia or fibrillation is considered at the present time as a factor linked to sudden death and justifies the implantation of an AICD. On the other hand, a normal resting ECG only associated with a provoked ST segment elevation by class I antiarrhythmic drug (flecainide) defines a group of patients with a low risk of sudden death, and these patients do not require the implantation of an AICD.
authors.affiliation: Service de cardiologie B, hôpital Trousseau, 37044 Tours cedex, France. d.babuty@chu-tours.fr
authors.forename: D
authors.initials: D
authors.lastname: Babuty
authors.forename: I
authors.initials: I
authors.lastname: Robin
authors.forename: L
authors.initials: L
authors.lastname: Fauchier
authors.forename: C
authors.initials: C
authors.lastname: Giraudeau
authors.forename: O
authors.initials: O
authors.lastname: Marie
authors.forename: Ph
authors.initials: P
authors.lastname: Poret
authors.forename: P
authors.initials: P
authors.lastname: Cosnay
mesh_terms: D016757:Death, Sudden, Cardiac / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D006801:Humans; D011322:Primary Prevention; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000628:therapy*