The nuclear lamina comes of age.
Many nuclear proteins form lamin-dependent complexes, including LEM-domain proteins, nesprins and SUN-domain proteins. These complexes have roles in chromatin organization, gene regulation and signal transduction. Some link the nucleoskeleton to cytoskeletal structures, ensuring that the nucleus and centrosome assume appropriate intracellular positions. These complexes provide new insights into cell architecture, as well as a foundation for the understanding of the molecular mechanisms that underlie the human laminopathies - clinical disorders that range from Emery-Dreifuss muscular dystrophy to the accelerated ageing seen in Hutchinson-Gilford progeria syndrome.
Gruenbaum
Yosef
Y
Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Jerusalem, 91904 Israel. gru@vms.huji.ac.il
Margalit
Ayelet
A
Goldman
Robert D
RD
Shumaker
Dale K
DK
Wilson
Katherine L
KL
D000199:Actins / Q000502:physiology; D000375:Aging / Q000378:metabolism; D000818:Animals; D018385:Centrosome / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D004268:DNA-Binding Proteins; D006801:Humans; D034882:Lamins / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology; D009136:Muscular Dystrophies / Q000209:etiology / Q000378:metabolism; D034881:Nuclear Lamina / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013946:Thymopoietins / Q000502:physiology
D000199:Actins; D004268:DNA-Binding Proteins; C405329:LEMD3 protein, human; D034882:Lamins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D013946:Thymopoietins; C092710:emerin