title: A photochemical entry to depsides: synthesis of gustastatin.
abstract: Herein, we propose a modular and general strategy to construct orcinol-type depsides based on the photolysis of functionalized benzodioxinones (I). Notably, resorcinylic esters are obtained without competing isocoumarin (II) formation, exemplified by the first total synthesis of gustastatin in 10 steps from commercially available trihydroxybenzoic acid. [Structure: see text]
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-9038, USA.
authors.forename: Jorge
authors.initials: J
authors.lastname: García-Fortanet
authors.forename: John R
authors.initials: JR
authors.lastname: Debergh
authors.forename: Jef K
authors.initials: JK
authors.lastname: De Brabander
mesh_terms: D007202:Indicators and Reagents; D029562:Magnoliaceae / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D007202:Indicators and Reagents; D010636:Phenols; C488055:gustastatin