title: Concentration-dependent collateral sensitivity of cisplatin-resistant gastric cancer cell sublines.
abstract: The cisplatin-resistant gastric cancer cell sublines, SNU-601/Cis2 and /Cis10, were 49 and >530 times more resistant to cisplatin, respectively, compared with the drug-sensitive cells, SNU-601/WT. The SNU-601/Cis2 showed cross-resistance to carboplatin, heptaplatin, doxorubicin, mitomycin C, and 5-fluorouracil compared with the SNU-601/WT whereas the SNU-601/Cis10 displayed collateral sensitivity to these drugs with the exception of cisplatin compared with the SNU-601/Cis2, suggesting that the cross-resistance and collateral sensitivity of cisplatin-resistant gastric cancer cells are dependent upon cisplatin concentrations. Altered expression of the antioxidant and transporter genes (metallothionein, catalase, superoxide dismutases, P-glycoprotein, and the breast cancer resistance protein) was involved in these phenotypes of the cisplatin-resistant gastric cancer cell lines.
authors.affiliation: Research Center for Resistant Cells, Chosun University, Gwangju 501-759, Republic of Korea.
authors.forename: Haidong
authors.initials: H
authors.lastname: Xu
authors.forename: Seok-Min
authors.initials: SM
authors.lastname: Choi
authors.forename: Chun-San
authors.initials: CS
authors.lastname: An
authors.forename: Young-Don
authors.initials: YD
authors.lastname: Min
authors.forename: Kweon-Cheon
authors.initials: KC
authors.lastname: Kim
authors.forename: Kyung-Jong
authors.initials: KJ
authors.lastname: Kim
authors.forename: Cheol-Hee
authors.initials: CH
authors.lastname: Choi
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D007928:Lethal Dose 50; D009363:Neoplasm Proteins / Q000378:metabolism*; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D002945:Cisplatin