title: Regulation of cap-dependent translation by eIF4E inhibitory proteins.
abstract: Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5' ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. joel.richter@umassmed.edu
authors.forename: Joel D
authors.initials: JD
authors.lastname: Richter
authors.forename: Nahum
authors.initials: N
authors.lastname: Sonenberg
mesh_terms: D000818:Animals; D039561:Eukaryotic Initiation Factor-4E / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D009420:Nervous System / Q000378:metabolism; D014176:Protein Biosynthesis; D012315:RNA Caps / Q000235:genetics / Q000378:metabolism*
chemical_list: D039561:Eukaryotic Initiation Factor-4E; D012315:RNA Caps