Regulation of cap-dependent translation by eIF4E inhibitory proteins.
Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5' ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.
Richter
Joel D
JD
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. joel.richter@umassmed.edu
Sonenberg
Nahum
N
D000818:Animals; D039561:Eukaryotic Initiation Factor-4E / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D009420:Nervous System / Q000378:metabolism; D014176:Protein Biosynthesis; D012315:RNA Caps / Q000235:genetics / Q000378:metabolism*
D039561:Eukaryotic Initiation Factor-4E; D012315:RNA Caps