title: New triple-helix DNA stabilizing agents.
abstract: Several substituted quinolin-4-amines and heteroaromatic analogs were synthesized and evaluated for interaction with triplex polydA.2polydT and duplex polydA.polydT by using UV-thermal melting experiments. Excellent triple-helix DNA ligands with high affinity toward T.A.T triplets and triple/duplex selectivity were designed through a rational approach.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. Lucjan@gsu.edu
authors.forename: Lucjan
authors.initials: L
authors.lastname: Strekowski
authors.forename: Maryam
authors.initials: M
authors.lastname: Hojjat
authors.forename: Ewa
authors.initials: E
authors.lastname: Wolinska
authors.forename: Alesia N
authors.initials: AN
authors.lastname: Parker
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Paliakov
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Gorecki
authors.forename: Farial A
authors.initials: FA
authors.lastname: Tanious
authors.forename: W David
authors.initials: WD
authors.lastname: Wilson
mesh_terms: D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D008024:Ligands; D009690:Nucleic Acid Conformation / Q000187:drug effects; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D011089:Polydeoxyribonucleotides / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013696:Temperature
chemical_list: D008024:Ligands; D011089:Polydeoxyribonucleotides; D011804:Quinolines; C098037:poly(dA)(poly(dT))2; C051802:triplex DNA; D004247:DNA