[Effect of photodynamic therapy combined with interstitial chemotherapy for gliomas].
OBJECTIVE
To investigate the therapeutic effect of photodynamic therapy (PDT) combined with interstitial chemo- therapy on gliomas after microsurgery.


METHODS
Twenty-eight patients with glioma received microsurgery for glioma resection as much as possible, during which PDT was carried out and an Ommaya bursa implanted into the cavity left by the resected tumor. PDT was performed again 24 h after the operation and carmustine injected into the Ommaya bursa for interstitial chemotherapy at the different time after the operation. The follow-up study lasted for 2 years.


RESULTS
Two of the 28 patients had relapse of glioma within 1 year after the operation, with the 1-year survival rate of 89.3% (25/28) and 2-year survival rate of 65.7% (17/28).


CONCLUSIONS
PDT combined with interstitial chemotherapy following microsurgery provides a safe and effective treatment of glioma, which can inhibit glioma growth, decrease the recurrence rate, prolong the patients' survival and improve their quality of live.
Chen
Li-feng
LF
Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. supertank@126.com
Ke
Yi-quan
YQ
Yang
Zhi-lin
ZL
Wang
Song-qing
SQ
Xu
Ru-xiang
RX
D000293:Adolescent; D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D002330:Carmustine / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D006801:Humans; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D010778:Photochemotherapy; D011184:Postoperative Period; D015996:Survival Rate
D018906:Antineoplastic Agents, Alkylating; D002330:Carmustine