Evaluation of lipid profile in adolescents during long-term use of combined oral hormonal contraceptives.
The study evaluated the effects of the long-term use of a combined oral hormonal contraceptive containing 30 microg ethinyl estradiol and 75 microg gestodene in adolescents. Thirty-three volunteers, aged from 14 to 19 years, who used the oral contraceptive for three consecutive years, were studied. Evaluation of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides was made before use and after 1, 2 and 3 years. During the 3-year study period, total cholesterol, HDL-C, LDL-C and triglyceride levels were significantly higher than previous measurements, but average values did not exceed the normal range. Compared to the first year, the second- and third-year cholesterol, HDL-C, LDL-C and triglyceride levels were not significantly different.
Guazzelli
Christina Aparecida Falbo
CA
Family Planning Clinic, Department of Obstetrics and Gynecology, Universidade Federal de São Paulo, São Paulo CEP 09090050, Brazil. guazzelli.toco@epm.br
Lindsey
Prescilla Chow
PC
de Araújo
Fabio Fernando
FF
Barbieri
Márcia
M
Petta
Carlos Alberto
CA
Aldrighi
Jose Mendes
JM
D000293:Adolescent; D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D009652:Norpregnenes / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003277:Contraceptives, Oral, Combined; D008055:Lipids; D009652:Norpregnenes; D014280:Triglycerides; C033273:Gestodene; D004997:Ethinyl Estradiol