Synthesis of cimiracemate B, a phenylpropanoid found in Cimicifuga racemosa.
The synthesis of the rare bioactive phenylpropanoid ester known as cimiracemate B (1) from black cohosh, Cimicifuga racemosa, is described. The procedure employs a coupling method using 1, l'-carbonyldiimidazole and methyltrifluoromethanesulfonate as coupling reagents in the presence of N-methylmorpholine.
Chen
Shao-Nong
SN
Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS, M/C 877) and UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St. Chicago, IL 60612, USA.
Fabricant
Daniel S
DS
Pauli
Guido F
GF
Fong
Harry H S
HH
Farnsworth
Norman R
NR
D031885:Cimicifuga / Q000737:chemistry*; D010666:Phenylpropionates / Q000138:chemical synthesis*; D010946:Plants, Medicinal
D010666:Phenylpropionates; C499963:cimiracemate B