title: Has survival improved for nasopharyngeal carcinoma in the United States?
abstract: OBJECTIVE
  To analyze the epidemiologic patterns and survival rates for patients with nasopharyngeal carcinoma over the last three decades.
  
  
  METHODS
  The National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) program tumor registries were used to identify patients with nasopharyngeal carcinoma in the United States from 1973 to 1999. Incidence and survival rates for each decade were then determined according to age, gender, race, histological type, and stage using the SEER statistical program.
  
  
  RESULTS
  From 1973 to 1999, 4680 cases of patients with nasopharyngeal carcinoma in the United States were sampled by the NCI /SEER database. Overall incidence rates for each decade essentially remained unchanged over time (0.7/100,000). Asians exhibited the highest incidence rates (3.0-4.2), followed by blacks (0.7-1.1) and then whites (0.4-0.7). In contrast, survival rates have gradually improved over time for all stages and histological types (35.7% 5-year survival in the 1970s vs. 44.1% in the 1980, and 51% in the 1990s). With respect to race, Asians demonstrated the best 5-year survival rate (62.9%) followed by whites (42.6%) and then blacks (36.2%). However, this may be due to histology, because Asians were also found to have a greater proportion of World Health Organization (WHO) type III cases (27.6%) in comparison to the other 2 groups (22.4% for blacks and 15% for whites).
  
  
  CONCLUSIONS
  Although the incidence rates of nasopharyngeal carcinoma have remained essentially unchanged in the United States in the last 3 decades, survival rates for each stage and histological subtype have exhibited considerable improvement over time. The higher survival rates in Asians may be partially attributed to the more favorable histology (type III) often seen in this group.
  
  
  METHODS
  B-3.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104, USA. jivianne.lee@uphs.upenn.edu
authors.forename: Jivianne T
authors.initials: JT
authors.lastname: Lee
authors.forename: Clifford Y
authors.initials: CY
authors.lastname: Ko
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000208:ethnology / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000401:mortality* / Q000473:pathology; D018426:SEER Program; D017678:Sex Distribution; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology