title: Obstructive jaundice as a presentation of ganglioneuroblastoma.
abstract: Obstructive jaundice is a rare symptom in the neuroblastic tumor. Seven cases of obstructive jaundice caused by neuroblastoma have been reported, and only three of these patients had the symptom at the onset of the disease. The authors report a case of ganglioneuroblastoma presenting with obstructive jaundice as a rare initial feature. After the histologic diagnosis with open biopsy, chemotherapy consisting of cisplatin, pirarubicin hydrochloride/doxorubicin, cyclophosphamide, and vincristine was given. The treatment resulted in reduction in the tumor size and relief of the obstructive jaundice. Complete resection of the tumor was possible after five courses of chemotherapy.
authors.affiliation: Department of Pediatrics, Jichi Medical School, Kawachi-gun, Tochigi-ken, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Ito
authors.forename: Takeji
authors.initials: T
authors.lastname: Uno
authors.forename: Yuji
authors.initials: Y
authors.lastname: Gunji
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Egami
authors.forename: Hideo
authors.initials: H
authors.lastname: Kawarasaki
authors.forename: Mariko Y
authors.initials: MY
authors.lastname: Momoi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D018305:Ganglioneuroblastoma / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology*; D008297:Male; D012186:Retroperitoneal Neoplasms / Q000150:complications* / Q000188:drug therapy; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; C027260:pirarubicin; D002945:Cisplatin