Cholesterol and amyloid beta fibrillogenesis.
Evidence is accumulating to suggest that cholesterol is a potent risk factor for the development of Alzheimer's disease. An increase in cholesterol level in neuronal membranes may facilitate the generation and aggregation of the amyloid beta-protein (Abeta). Our results and those of other groups suggest that cholesterol has both direct and indirect effects of acceleration of Abeta fibrillogenesis. A novel concept of cholesterol neurobiology is necessary to elucidate the mechanism underlying cholesterol-dependent Abeta pathology.
Yanagisawa
Katsuhiko
K
National Institute for Longevity Sciences, 474-8522 Obu, Japan.
D000544:Alzheimer Disease / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D005677:G(M1) Ganglioside / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D016874:Neurofibrillary Tangles / Q000473:pathology; D009474:Neurons / Q000502:physiology; D058225:Plaque, Amyloid / Q000473:pathology; D011485:Protein Binding; D012307:Risk Factors
D016229:Amyloid beta-Peptides; D046911:Macromolecular Substances; D005677:G(M1) Ganglioside; D002784:Cholesterol