title: [Cardiovascular dysfunction following severe scorpion envenomation. Mechanisms and physiopathology].
abstract: The seriousness of scorpion envenomation results essentially from left cardiac function with pulmonary oedema and/or a state of shock. Adrenergic myocarditis, toxic myocarditis and myocardial ischemia are the 3 mechanisms that explain the cardiac dysfunction. Myocardial ischemia is not only due to the release of catecolamines but also the effect of the cytokines and/or neuropeptide Y on the coronary vessels. The cardiac damage can be due or enhanced by the depressive effect of the cytokines on the myocardial cells. The frequently observed hyperglycaemia only enhances the state of the already damaged myocardium.
authors.affiliation: Service de réanimation médicale, CHU Habib Bourguiba, Sfax, Tunisie. bahloulmab@yahoo.fr
authors.forename: Mabrouk
authors.initials: M
authors.lastname: Bahloul
authors.forename: Hatem
authors.initials: H
authors.lastname: Kallel
authors.forename: Noureddine
authors.initials: N
authors.lastname: Rekik
authors.forename: Chokri
authors.initials: C
authors.lastname: Ben Hamida
authors.forename: Hédi
authors.initials: H
authors.lastname: Chelly
authors.forename: Mounir
authors.initials: M
authors.lastname: Bouaziz
mesh_terms: D000138:Acidosis / Q000209:etiology / Q000503:physiopathology; D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D002395:Catecholamines / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D019332:Endothelin-1 / Q000502:physiology; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D009205:Myocarditis / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D009206:Myocardium / Q000166:cytology / Q000276:immunology; D009478:Neuropeptide Y / Q000502:physiology; D011654:Pulmonary Edema / Q000209:etiology / Q000503:physiopathology; D065008:Scorpion Stings / Q000150:complications*; D012604:Scorpion Venoms / Q000009:adverse effects; D012605:Scorpions; D012770:Shock, Cardiogenic / Q000209:etiology / Q000503:physiopathology; D013312:Stress, Physiological / Q000209:etiology / Q000503:physiopathology; D001620:beta-Thromboglobulin / Q000502:physiology
chemical_list: D002395:Catecholamines; D016207:Cytokines; D019332:Endothelin-1; D009478:Neuropeptide Y; D012604:Scorpion Venoms; D001620:beta-Thromboglobulin