[Effect of mica monomer granule on gastrin, somatostatin and G cells as well as D cells of gastric mucosa in CAG rat].
OBJECTIVE
To study regulative action of mica monomer granule preparation on gastrin (GAS), somatostatin (SS) and G cells as well as D cells of gastric mucosa in experimental chronic atrophic gastritis (CAG) rat.


METHODS
CAG rats were treated with mica monomer granule preparation with three different dosages--high, moderate and low level respectively. Changes of blood serum GAS, blood plasma SS and G cells as well as D cells of gastric mucosa in CAG rats were observed and detected with ELISA method, RIA method and immunocytochemistry method.


RESULTS
Mica monomer granule of three different dosages could increase the quantity of G cells as well as D cells of gastric mucosa and the concentration of blood serum GAS and decrease the content of blood plasma SS in CAG rat at different level respectively. It was more effective in high and moderate dosage groups.


CONCLUSIONS
Mica has the pharmacological action of protecting gastric mucosa, promoting the palingenesis of gastric gland and enhancing blood stream of gastric mucosa consequently to abate the inflammation reaction of gastric mucosa. Its effective mechanism is associated with the neuroendocrine regulative mechanism of promoting the secretion of gastric acid and gastric pepsin by increasing the amount of G cells as well as D cells and the concentration of blood serum GAS, and reducing inhibiting action on GAS secretion and enhancing the secretion of GAS by decreasing the content of SS.
Zhu
Fang-shi
FS
Sir Run Run Shaw Clinical Medical Institute, Zhejiang University, Hangzhou 310016, China. zhufs@tom.com
Wang
Liang-jing
LJ
Si
Jian-min
JM
Wang
Dong-fei
DF
Chen
Ping
P
D000538:Aluminum Silicates / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000473:pathology*; D019863:Gastrin-Secreting Cells / Q000187:drug effects; D005755:Gastrins / Q000097:blood*; D005757:Gastritis, Atrophic / Q000097:blood / Q000473:pathology*; D008419:Materia Medica / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000097:blood*; D019864:Somatostatin-Secreting Cells / Q000187:drug effects
D000538:Aluminum Silicates; D005755:Gastrins; D008419:Materia Medica; D013004:Somatostatin; C011934:mica