title: [Expression and significance of epidermal growth factor receptor variant type III in hepatocellular carcinoma].
abstract: OBJECTIVE
  Many evidences show that epidermal growth factor receptor variant type III (EGFRvIII) plays an important role in initiation and progression of various cancers. But the relationship between EGFRvIII and hepatocellular carcinoma (HCC) is unclear. This study was to explore the expression and significance of EGFRvIII in human HCC tissues.
  
  
  METHODS
  Immunohistochemical staining (IHC) was used to detect the expression of EGFRvIII in 55 specimens of HCC tissues and their adjacent non-cancerous liver tissues.
  
  
  RESULTS
  Positive rate of EGFRvIII in HCC tissue was significantly higher than that in adjacent non-cancerous liver tissue [61.8% (34/55) vs. 38.2% (21/55), P < 0.05]. Positive rate of EGFRvIII in HCC tissue was significantly correlated with clinical stage,portal vein tumor thrombus,presence of extrahepatic metastasis, tumor recurrence, and the diameter of tumor, but not correlated with the number of foci, serum alpha-fetoprotein (AFP) level, serum HBsAg status, tumor differentiation, and cirrhosis in adjacent liver tissue.
  
  
  CONCLUSIONS
  EGFRvIII is over-expressed in human HCC tissues, and relates to progression and recurrence of HCC.
authors.affiliation: Department of Experiment Pathology, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, P. R. China. ouchao@sohu.com
authors.forename: Chao
authors.initials: C
authors.lastname: Ou
authors.forename: Fei-Xiang
authors.initials: FX
authors.lastname: Wu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Luo
authors.forename: Ji
authors.initials: J
authors.lastname: Cao
authors.forename: Yin-Nong
authors.initials: YN
authors.lastname: Zhao
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Yuan
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Jian-Jia
authors.initials: JJ
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating; D011169:Portal Vein / Q000473:pathology
chemical_list: C410723:epidermal growth factor receptor VIII; D066246:ErbB Receptors