title: Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors.
abstract: A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.forename: Pavel A
authors.initials: PA
authors.lastname: Petukhov
authors.forename: Mira
authors.initials: M
authors.lastname: Jung
authors.forename: Alfredo
authors.initials: A
authors.lastname: Velena
authors.forename: Elena
authors.initials: E
authors.lastname: Eliseeva
authors.forename: Anatoly
authors.initials: A
authors.lastname: Dritschilo
authors.forename: Alan P
authors.initials: AP
authors.lastname: Kozikowski
mesh_terms: D000081:Acetamides / Q000737:chemistry* / Q000494:pharmacology*; D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000081:Acetamides; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D013438:Sulfhydryl Compounds