title: Galanin-like peptide stimulates vasopressin, oxytocin and adrenocorticotropic hormone release in rats.
abstract: Galanin-like peptide is a recently identified neuropeptide. We examined the effects of stressful stimuli on expression of c-Fos protein in galanin-like peptide neurons, and the effects of central infusion of galanin-like peptide on release of stress hormones, vasopressin, oxytocin and adrenocorticotropic hormone, in male rats. Foot shock stress induced expression of c-Fos protein in galanin-like peptide neurons in the hypothalamus. Intracerebroventricular injection of galanin-like peptide significantly increased plasma concentrations of vasopressin, oxytocin and adrenocorticotropic hormone. Galanin-like peptide also increased blood pressure, heart rates and plasma glucose concentrations, but significantly changed neither plasma osmolality nor blood haemoglobin concentration. A neuropeptide Y-Y1 receptor antagonist, BIBP3226, did not significantly change galanin-like peptide-induced hormone release. It is possible that galanin-like peptide is involved in vasopressin, oxytocin and adrenocorticotropic hormone release from the pituitary during stress.
authors.affiliation: Department of Physiology, Jichi Medical School, Minamikawachi-machi, Tochigi-ken 329-0498, Japan. tonaka@jichi.ac.jp
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Onaka
authors.forename: Motoki
authors.initials: M
authors.lastname: Kuramochi
authors.forename: Jun
authors.initials: J
authors.lastname: Saito
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ueta
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yada
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002452:Cell Count / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004597:Electroshock / Q000379:methods; D044089:Galanin-Like Peptide / Q000378:metabolism / Q000494:pharmacology*; D007031:Hypothalamus / Q000166:cytology*; D007150:Immunohistochemistry / Q000379:methods; D007276:Injections, Intraventricular / Q000379:methods; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009994:Osmolar Concentration; D010121:Oxytocin / Q000097:blood*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors; D013997:Time Factors; D014667:Vasopressins / Q000097:blood*
chemical_list: D001786:Blood Glucose; D044089:Galanin-Like Peptide; D016760:Proto-Oncogene Proteins c-fos; D017476:Receptors, Neuropeptide Y; D014667:Vasopressins; D010121:Oxytocin; D000324:Adrenocorticotropic Hormone