Characterization of a novel allele HLA-B*3549.
A novel HLA-B allele, B*3549, was identified in a bone marrow transplantation candidate. B*3549 differs from B*3525 by two nucleotides at exon 2, position 142 (T to G) and 165 (G to C). The difference at position 142 resulted in an amino acid difference (serine to alanine). However, the difference at position 165 did not cause any amino acid change. This novel allele was found on a haplotype with A*3101, B*3549, Cw*0401, DRB1*0407, and DQB1*0302.
Chang
Y
Y
HLA Laboratory, All Children's Hospital, St. Petersburg, FL 33701, USA. changy@allkids.org
Desai
L
L
Fan
T X
TX
Santana
Z
Z
Day
N K
NK
D000483:Alleles; D001483:Base Sequence; D016026:Bone Marrow Transplantation; D005260:Female; D015235:HLA-B Antigens / Q000145:classification / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D012689:Sequence Homology, Nucleic Acid
D015235:HLA-B Antigens; D006684:HLA-DR Antigens