Characteristics of interpolyelectrolyte complexes of Eudragit E100 with Eudragit L100.
With a view to the application in oral controlled drug delivery systems, the formation of interpolyelectrolyte complexes (IPEC) between Eudragit E100 (EE) and Eudragit L100 (EL) was investigated, using turbidimetry, solution viscosity measurements and elementary analysis. The structure of the synthesized IPEC was investigated by using FT-IR spectroscopy. The binding ratio of a unit molecule of EL with EE was found to be approximately 1:1 in pH 6.0. Based on the results of elementary analysis, and FT-IR, the binding ratio of each component in the solid complexes was very close to that observed in turbidity and viscosity measurements and indicate that the synthesized products can be considered as IPEC. Due to the structure of the IPEC, two maxima were observed in the swelling behaviour as a function of pH. The release of the model drug ibuprofen was significantly retarded from tablets made up of the IPEC.
Moustafine
R I
RI
Department of Pharmaceutical Chemistry, State Medical University of Kazan, Kazan, Russia.
Kabanova
T V
TV
Kemenova
V A
VA
Van den Mooter
G
G
D000179:Acrylates / Q000737:chemistry* / Q000493:pharmacokinetics*; D011073:Polyamines / Q000737:chemistry / Q000493:pharmacokinetics; D000071228:Polyelectrolytes; D011108:Polymers / Q000737:chemistry* / Q000493:pharmacokinetics*; D011109:Polymethacrylic Acids / Q000737:chemistry* / Q000493:pharmacokinetics*
D000179:Acrylates; D011073:Polyamines; D000071228:Polyelectrolytes; D011108:Polymers; D011109:Polymethacrylic Acids; C477020:Eudragit E100; C038300:methylmethacrylate-methacrylic acid copolymer