title: The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists.
abstract: Bipiperidine amide 1 has been identified as a CC chemokine receptor 3 (CCR3) antagonist. Optimization of its structure-activity relationship has resulted in the identification of cis (R,R)-4-[(3,4-dichlorophenyl)methyl]-3-hydroxymethyl-1'(6-quinolinylcarbonyl)-1,4'-bipiperidine 14n, which exhibits potent receptor affinity and inhibition of both calcium flux and eosinophil chemotaxis.
authors.affiliation: Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. pauline.ting@spcorp.com
authors.forename: Pauline C
authors.initials: PC
authors.lastname: Ting
authors.forename: Joe F
authors.initials: JF
authors.lastname: Lee
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: Shelby P
authors.initials: SP
authors.lastname: Umland
authors.forename: Robert
authors.initials: R
authors.lastname: Aslanian
authors.forename: Jianhua
authors.initials: J
authors.lastname: Cao
authors.forename: Youhao
authors.initials: Y
authors.lastname: Dong
authors.forename: Charles G
authors.initials: CG
authors.lastname: Garlisi
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Gilbert
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: James
authors.initials: J
authors.lastname: Jakway
authors.forename: Joseph
authors.initials: J
authors.lastname: Kelly
authors.forename: Zhidan
authors.initials: Z
authors.lastname: Liu
authors.forename: Stuart
authors.initials: S
authors.lastname: McCombie
authors.forename: Himanshu
authors.initials: H
authors.lastname: Shah
authors.forename: Fang
authors.initials: F
authors.lastname: Tian
authors.forename: Yuntao
authors.initials: Y
authors.lastname: Wan
authors.forename: Neng-Yang
authors.initials: NY
authors.lastname: Shih
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; C515350:CCR3 protein, human; D010880:Piperidines; D054397:Receptors, CCR3; D019707:Receptors, Chemokine