[Experimental study of the pulpal response of dogs capping with nHA-PA66].
OBJECTIVE
To investigate the responses of dog pulp tissue to the new nano-hydroxyapatite/polyamide 66 biological composites (nHA-PA66) used as direct pulp capping agent.


METHODS
Dogs were used in establishing the experimental model. The reparative dentin bridge formation and the histopathological changes at the pulp-exposed site were observed at 7, 30 and 60 days postoperatively. Calcium hydroxide (Dycal) was used as positive control.


RESULTS
After capping with nHA-PA66, some dog teeth were found to have formation of reparative dentin bridge and slight inflammatory response during the pulp healing procedure when compared with the effect of using calcium hydroxide.


CONCLUSIONS
The results indicate that nHA-PA66 has good tissue biocompatibility, but its function of inducing reparative dentin bridge formation is not good enough as compared with that of calcium hydroxide. It has the potential to be used as a direct pulp capping agent, but further researches are needed.
Su
Qin
Q
West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Ye
Ling
L
Zhou
Xue-dong
XD
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity; D003736:Dental Cavity Lining; D003782:Dental Pulp / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D003785:Dental Pulp Capping / Q000379:methods*; D003804:Dentin / Q000187:drug effects; D004285:Dogs; D017886:Durapatite / Q000633:toxicity*; D036103:Nanotechnology; D009757:Nylons / Q000633:toxicity; D011897:Random Allocation; D012387:Root Canal Filling Materials / Q000633:toxicity*; D012390:Root Canal Therapy / Q000379:methods
D001672:Biocompatible Materials; D009757:Nylons; D012387:Root Canal Filling Materials; D017886:Durapatite