Soluble platelet glycoprotein V is a marker of thrombosis in patients with ischemic stroke.
OBJECTIVE
The diagnosis and management of patients with acute ischemic stroke still lack an informative biochemical test. Soluble glycoprotein V (sGPV) is a new plasmatic marker of thrombosis released from the platelet surface by thrombin. The objective of this prospective study was to compare the levels of sGPV in stroke and control patients.


METHODS
Consecutive patients with acute ischemic stroke (n=159) and controls (n=70) were recruited for sGPV measurement.


RESULTS
Plasmatic levels of sGPV were significantly increased in ischemic stroke compared with control patients (median [interquartile range] 39.4 [31.8 to 52.9] versus 28.1 [24.0 to 37.9] ng/mL; P<0.0001). In multivariate analysis, ischemic stroke was the major determinant of the sGPV increase (odds ratio [95% CI], 5.87 [2.62 to 13.12]; P<0.0001).


CONCLUSIONS
sGPV is a new marker of arterial thrombosis and represents a tool to study the mechanisms involved in ischemic stroke. The increase in plasmatic sGPV observed in stroke patients supports a role of platelets and thrombin in the events leading to ischemic stroke.
Wolff
Valérie
V
Etablissement Français du Sang-Alsace, Strasbourg, France.
Aleil
Boris
B
Giroud
Maurice
M
Lorenzini
Jean-Louis
JL
Meyer
Nicolas
N
Wiesel
Marie-Louise
ML
Cazenave
Jean-Pierre
JP
Lanza
François
F
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood*; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012995:Solubility; D020521:Stroke / Q000097:blood*; D013927:Thrombosis / Q000175:diagnosis*
D015415:Biomarkers; D019038:Platelet Glycoprotein GPIb-IX Complex