Optimal path to epigenetic switching.
We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.
Roma
David Marin
DM
Department of Physics and Astronomy and BioMaPS Institute, Rutgers University, Piscataway, New Jersey 08854, USA.
O'Flanagan
Ruadhan A
RA
Ruckenstein
Andrei E
AE
Sengupta
Anirvan M
AM
Mukhopadhyay
Ranjan
R
D000222:Adaptation, Physiological / Q000235:genetics; D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D005809:Genes, Regulator / Q000502:physiology*; D006801:Humans; D008957:Models, Genetic; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D015533:Transcriptional Activation / Q000502:physiology*
D014157:Transcription Factors