Drug interactions with angiotensin receptor blockers.
Many patients with high blood pressure receive multiple medications for hypertension and other conditions, placing them at risk for adverse drug interactions. Additionally, as the prevalence of hypertension increases with age, factors like greater frailty, comorbidity of the elderly requiring polypharmacy, and reduced hepatic and renal clearance rates for the elimination of drugs increase the likelihood of drug interactions. Angiotensin receptor blockers (ARBs) are the most recent class of agents for the treatment of hypertension. Due to a favourable side effect profile, this class of drugs deserves increased attention. This article reviews drug interactions of ARBs and suggests measures for reducing the risk of adverse events when drugs are co-administered. MEDLINE, EMBASE, Cochrane library, and CINAHL were searched. Reported and likely clinical relevant interactions of ARBs with concomitantly given drugs are summarised in Table 2 and 3. Compared to other classes of antihypertensive agents, the ARBs appear to have a low potential for drug interactions; however, interactions with this class occur and variations within the class have been detected, mainly due to different affinities for cytochrome P450 isoenzymes.
Böhler
Steffen
S
Technical University of Dresden, Institute of Clinical Pharmacology, Medical Faculty Carl Gustav Carus, Fiedlerstrasse 27, D-01307 Dresden, Germany. steffen.boehler@mailbox.tu-dresden.de
Pittrow
David
D
Bramlage
Peter
P
Kirch
Wilhelm
W
D047228:Angiotensin II Type 1 Receptor Blockers / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007527:Isoenzymes; D012307:Risk Factors
D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System