[Effect of early nutritional support on plasma superoxide dismutase, malondialdehyde and nitric oxide in rats with burns in a hot and humid environment].
OBJECTIVE
To observe the changes of plasma superoxide dismutase (SOD), malondialdehyde (MDA) and nitric oxide (NO) in rats with combined stress of burn injury and hot and humid environment.


METHODS
The rats with superficial second-degree scald were subjected to intragastric administration of double-distilled water for one week (control group) or treated with ascorbic acid and L-arginine mixed with a-Tocopherol for one week (treatment group). All the rats were exposed to the same hot and humid environment of Td 37+/-0.5 degrees C with relative humidity of 65%+/-5% for 1-2 h. Observation was performed at 1, 2, 4, and 10 h after the heat exposure, respectively.


RESULTS
SOD and MDA changes were significantly different between the two groups (P<0.01, P<0.05). In the control group, NO levels at 1 h were significantly different from those measured at 2 and 6 h after the exposure (P<0.01, P<0.05).


CONCLUSIONS
Early nutritional support can significantly reduce the stress organ injuries, and prevent complications following injury in a hot and humid environment.
Wang
Ying
Y
Department of Nursing Administration, Nanfang Hospital, Guangzhou, China. shadow@fimmu.com
Li
Ya-jie
YJ
Zhai
Hui-min
HM
Xu
Cai-xia
CX
Luo
Bing-de
BD
D000818:Animals; D002056:Burns / Q000097:blood* / Q000178:diet therapy; D002980:Climate; D006358:Hot Temperature; D006813:Humidity; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood*; D018529:Nutritional Support; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood*; D013997:Time Factors
D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase