title: Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives.
abstract: We examined the human immunodeficiency virus-reverse transcriptase and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of cationic, anionic, and amino acid-type fullerene derivatives. Among the fullerene derivatives, the amino acid-type fullerene derivative was the most efficient in human immunodeficiency virus-reverse transcriptase inhibition.
authors.affiliation: Kyoritsu University of Pharmacy, Shibakoen 1-5-30, Minato-ku, Tokyo 105-8512, Japan. mashino-td@kyoritsu-ph.ac.jp
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Mashino
authors.forename: Kumiko
authors.initials: K
authors.lastname: Shimotohno
authors.forename: Noriko
authors.initials: N
authors.lastname: Ikegami
authors.forename: Dai
authors.initials: D
authors.lastname: Nishikawa
authors.forename: Kensuke
authors.initials: K
authors.lastname: Okuda
authors.forename: Kyoko
authors.initials: K
authors.lastname: Takahashi
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
authors.forename: Masataka
authors.initials: M
authors.lastname: Mochizuki
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology; D054303:HIV Reverse Transcriptase / Q000187:drug effects; D016174:Hepacivirus / Q000201:enzymology*; D006801:Humans; D020128:Inhibitory Concentration 50; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors*; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D037741:Fullerenes; D018894:Reverse Transcriptase Inhibitors; D012324:RNA-Dependent RNA Polymerase; D054303:HIV Reverse Transcriptase