West syndrome associated with administration of a histamine H1 antagonist, oxatomide.
We report a 4-month-old female infant who developed West syndrome eleven days after administration of a histamine H1 antagonist, oxatomide, for atopic dermatitis. It has been reported that some histamine H1 antagonists induce seizures in epileptic patients. The age, the interval between oxatomide administration, and the onset of West syndrome and its clinical course were similar to two previously reported 3-month-old infants with West syndrome associated with ketotifen administration. We should be cautious in using the histamine H1 antagonists, oxatomide and ketotifen, in young infants because such agents could potentially disturb the anticonvulsive central histaminergic system.
Yamashita
Yushiro
Y
Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume 830-0011, Japan. yushiro@med.kurume-u.ac.jp
Isagai
Takeo
T
Seki
Yoshitaka
Y
Ohya
Takashi
T
Nagamitsu
Shinichiro
S
Matsuishi
Toyojiro
T
D005260:Female; D006634:Histamine H1 Antagonists / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D010879:Piperazines / Q000009:adverse effects*; D013036:Spasms, Infantile / Q000139:chemically induced*
D006634:Histamine H1 Antagonists; D010879:Piperazines; C015408:oxatomide