Chemoprevention of N-nitrosodiethylamine induced phenobarbitol promoted liver tumors in rat by extract of Indigofera aspalathoides.
The chemopreventive effect of ethanol extract of Indigofera aspalathoides (EIA) on N-nitrosodiethylamine (DEN, 200 mg/kg)-induced experimental liver tumor was investigated in male Wistar rats. Oral administration of ethanol extract of Indigofera aspalathoides (250 mg/kg) effectively suppressed liver tumor induced with DEN as revealed by decrease in the levels of extend of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP), lipid peroxidase (LPO), glutathione peroxidase (Gpx) and glutathione S-transferase (GST) with a concomitant increase in enzymatic antioxidant (superoxide dismutase and catalase) levels when compared to those in liver tumor bearing rats. The histopathological changes of liver sample were compared with respective control. Our results show a significant chemopreventive effect of EIA against DEN induced liver tumor.
Rajkapoor
Balasubramanian
B
Department of Pharmacology, Vinayaka Mission's College of Pharmacy, Salem-636 008 Tamilnadu, India. rajkapoorb@yahoo.co.in
Murugesh
Narayanan
N
Chodon
Dechen
D
Sakthisekaran
Dhanapal
D
D000818:Animals; D018890:Chemoprevention; D004052:Diethylnitrosamine / Q000633:toxicity*; D004357:Drug Synergism; D029883:Indigofera; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D010634:Phenobarbital / Q000633:toxicity*; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D004052:Diethylnitrosamine; D010634:Phenobarbital