Enhanced expression of PP1gamma1, a catalytic subunit isoform of protein phosphatase type1 and expression of telomerase activity in Ewing's sarcoma cells.
We previously reported that PP1gamma1 is highly expressed in osteosarcoma and chondrosarcoma, and suggested that this protein plays a role in malignancy of osteogenic tumors. In this study, we investigated the correlation of the expression of PP1gamma1 with telomerase activity. PP2A protein was not positive in any of the 5 cases of Ewing's sarcoma, but PP1gamma1 protein was strongly positive in all cases. Furthermore, malignant cells had high telomerase activity. We investigated the correlation of the expression of PP1gamma1 with telomerase activity, and showed that telomerase activity is regulated by protein phosphorylation in Ewing's sarcoma cells.
Mori
Satoshi
S
Department of Orthopaedic Surgery, Kagawa Medical College, Miki-cho, Kagawa 761-0701, Japan. stmori@kms.ac.jp
Cao
Yongping
Y
Yamadab
Takahisa
T
Sogawa
Kenichi
K
Kondo
Kazuya
K
Hino
Norifumi
N
Miyazaki
Tatsuhiko
T
Kawaguchi
Yoji
Y
Oka
Shiro
S
Kawasaki
Kojiro
K
Mashiba
Tasuku
T
Norimatsu
Hiromichi
H
D002813:Chondrosarcoma / Q000378:metabolism; D006801:Humans; D012516:Osteosarcoma / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000502:physiology*; D010766:Phosphorylation; D012512:Sarcoma, Ewing / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D019098:Telomerase / Q000378:metabolism*
D019098:Telomerase; D010749:Phosphoprotein Phosphatases