Body mass index, follicle-stimulating hormone and their predictive value in in vitro fertilization.
OBJECTIVE
The objective was to explore whether body mass and day 3 follicle-stimulating hormone have predictive value on odds of pregnancy after in vitro fertilisation. Few studies show that obesity produces a variety of alterations in the reproductive system, and that women with an elevation of day 3 FSH have declining ovarian function.


METHODS
The data of one-hundred-seventy-one women who underwent a standard regime of controlled ovarian hyperstimulation was analyzed with particular reference to variations in body mass and hormone levels.


RESULTS
By raising BMI and FSH (mIU/mL) by one unit, the odds for pregnancy were decreased by the respective factors 0.84 (95% confidence interval 0.73-0.97) and 0.77 (95% confidence interval 0.59-1.00).


CONCLUSIONS
The results demonstrate that for the purpose of raising the odds of pregnancy BMI should be reduced. A low FSH value may cause the same effect. Nontheless, obesity and hormonal function may be independent risk factors for failure in assisted reproduction.
Ferlitsch
Kathrin
K
Department of Obstetrics and Gynaecology, University of Vienna, General Hospital, Vienna, Austria. kathrin.ferlitsch@akh-wien.ac.at
Sator
Michael O
MO
Gruber
Doris M
DM
Rücklinger
Ernst
E
Gruber
Christian J
CJ
Huber
Johannes C
JC
D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007247:Infertility, Female; D015233:Models, Statistical; D009765:Obesity; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012044:Regression Analysis; D012307:Risk Factors
D005640:Follicle Stimulating Hormone