title: Control of traveling waves in the Mammalian cortex.
abstract: We experimentally confirmed predictions that modulation of the neuronal threshold with electrical fields can speed up, slow down, and even block traveling waves in neocortical slices. The predictions are based on a Wilson-Cowan-type integro-differential equation model of propagating neocortical activity. Wave propagation could be modified quickly and reversibly within targeted regions of the network. To the best of our knowledge, this is the first example of direct modulation of the threshold to control wave propagation in a neural system.
authors.affiliation: Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia 22030, USA.
authors.forename: Kristen A
authors.initials: KA
authors.lastname: Richardson
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Schiff
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Gluckman
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology* / Q000528:radiation effects; D003198:Computer Simulation; D004558:Electric Stimulation / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D004574:Electromagnetic Fields; D008297:Male; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D009435:Synaptic Transmission / Q000502:physiology* / Q000528:radiation effects