title: Periodic deworming with albendazole and its impact on growth status and diarrhoeal incidence among children in an urban slum of India.
abstract: This study was undertaken to measure the impact of periodic deworming with albendazole on growth status and incidence of diarrhoea in children aged 2-5 years in an urban setting in India and to assess the feasibility of local health workers implementing the procedures involved. This was a double-blind, placebo-controlled, randomized, community-based intervention trial with 702 children randomly allocated to receive either albendazole or placebo. The two study groups received two doses of albendazole (400 mg) or placebo six months apart. Mean weight increased significantly in the albendazole group compared to the control group at three months, six months and nine months following treatment (P<0.01, P<0.01 and P<0.001 respectively). The albendazole group also experienced fewer episodes of diarrhoea than their control counterparts (relative risk 1.3, 95% CI 1.07-1.53) with a 28% reduction. The health workers administered the correct dosage satisfactorily and there were no adverse effects. Thus, periodic mass deworming with albendazole would seem to be a safe and effective method that could be adopted at the community level or as an integral part of school health services and could be expected to improve growth and reduce the incidence of diarrhoea in children.
authors.affiliation: National Institute of Cholera and Enteric Diseases, P-33, C.I.T. Road, Scheme XM, Beliaghata, Kolkata 700010, India. dipikasur@hotmail.com
authors.forename: D
authors.initials: D
authors.lastname: Sur
authors.forename: D R
authors.initials: DR
authors.lastname: Saha
authors.forename: B
authors.initials: B
authors.lastname: Manna
authors.forename: K
authors.initials: K
authors.lastname: Rajendran
authors.forename: S K
authors.initials: SK
authors.lastname: Bhattacharya
mesh_terms: D015766:Albendazole / Q000627:therapeutic use*; D000871:Anthelmintics / Q000627:therapeutic use*; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology / Q000469:parasitology* / Q000517:prevention & control; D004311:Double-Blind Method; D005260:Female; D006373:Helminthiasis / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D014504:Urban Health; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000871:Anthelmintics; D015766:Albendazole