[Delta-opioid receptor agonists prevent the irreversible damage of cardiomyocytes in ischemized-reperfused isolated rat heart].
Pretreatment with selective delta-opioid receptor (delta-OR) agonists decreased the level of creatine kinase in the coronary effluent of isolated rat heart during a 45-min global ischemia and a 30-min reperfusion. The effect was completely abolished after pretreatment of the delta-OR antagonist nitrindole. At the same time, pretreatment with mu-OR antagonists did not affect the level of creatine kinase in the coronary effluent. It is suggested that stimulation of the cardiac delta-OR prevents the irreversible cardiac cell damage during global ischemia and reperfusion in vitro. In contrast, the cardiac mu-OR do not play any significant role in regulation of the cardiac resistance to the pathogenic action of ischemia and reperfusion.
Platonov
A A
AA
Lasukova
T V
TV
Maslov
L N
LN
Downey
J M
JM
Nagaze
H
H
Ovchinnikov
M V
MV
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000503:physiopathology*; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000819:agonists*
D000700:Analgesics; D017465:Receptors, Opioid, delta