title: Failure of moxidectin to control benzimidazole-, levamisole- and ivermectin-resistant Teladorsagia circumcinda in a sheep flock.
abstract: Control of a benzimidazole-, levamisole- and ivermectin-resistant population of Teladorsagia circumcincta was attempted using moxidectin administered orally at the manufacturer's recommended dose rate of 200 microg/kg bodyweight. Ewes were dosed after lambing with the aim of controlling their periparturient rise in faecal egg output and lambs were dosed at six-week intervals throughout the summer. This regimen failed to suppress the establishment of significant numbers of infective helminth larvae on the pasture, resulting in unsatisfactory lamb production. Oral dosing with moxidectin was effective in removing adult female burdens of ivermectin-resistant T. circumcincta, but the effect of the drug did not persist against the resistant helminth population.
authors.affiliation: Large Animal Practice, Royal (Dick) School of Veterinary Studies, Easter Bush Veterinary Centre, Roslin, Midlothian.
authors.forename: N D
authors.initials: ND
authors.lastname: Sargison
authors.forename: F
authors.initials: F
authors.lastname: Jackson
authors.forename: D J
authors.initials: DJ
authors.lastname: Bartley
authors.forename: A C P
authors.initials: AC
authors.lastname: Moir
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use; D005243:Feces / Q000469:parasitology; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D007559:Ivermectin / Q000494:pharmacology / Q000627:therapeutic use; D007978:Levamisole / Q000494:pharmacology / Q000627:therapeutic use; D018942:Macrolides / Q000494:pharmacology / Q000627:therapeutic use*; D010270:Parasite Egg Count / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D014251:Trichostrongyloidea / Q000187:drug effects* / Q000254:growth & development; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D018942:Macrolides; D007978:Levamisole; D007559:Ivermectin; C031000:benzimidazole; C027837:moxidectin