Are there subgroups of bulimia nervosa based on comorbid psychiatric disorders?
OBJECTIVE
The current study sought to determine whether there are subtypes of bulimia nervosa (BN) differentiated by comorbid psychiatric disorders.


METHODS
Data on comorbid psychiatric diagnoses in female relatives of probands and controls in the Collaborative Study of the Genetics of Alcoholism (COGA) who met criteria for BN (as outlined in the 3rd Rev. ed. of the Diagnostic and Statistical Manual of Mental Disorders) were analyzed using latent class analysis. Resulting latent classes were compared on a variety of variables related to impulsive behaviors and psychological functioning.


RESULTS
The best-fitting solution, a two-class model, yielded one class (72%) characterized by substance dependence, depression, antisocial personality disorder (ASPD), and anxiety disorders, and another characterized by depression. The highly comorbid class had more suicidality, more daily smokers, sought help for emotional problems, and had lower Global Assessment of Functioning (GAF) scores compared with those in the comorbid depression only class.


CONCLUSIONS
Latent class findings suggest the existence of two classes of BN differentiated by substance dependence, impulsive behaviors, and poorer psychological functioning.
Duncan
Alexis E
AE
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Neuman
Rosalind J
RJ
Kramer
John
J
Kuperman
Samuel
S
Hesselbrock
Victor
V
Reich
Theodore
T
Bucholz
Kathleen K
KK
D000328:Adult; D002032:Bulimia / Q000145:classification* / Q000235:genetics / Q000523:psychology*; D016022:Case-Control Studies; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D007174:Disruptive, Impulse Control, and Conduct Disorders; D005260:Female; D006801:Humans; D001523:Mental Disorders / Q000523:psychology*; D008875:Middle Aged; D010375:Pedigree; D011594:Psychometrics; D019966:Substance-Related Disorders