Low-valent Nb(III)-mediated synthesis of 1,1,2-trisubstituted-1H-indenes from aliphatic ketones and aryl-substituted alkynes.
A variety of 1,1,2-trisubstituted-1H-indenes are synthesized by the reaction of aliphatic ketones, aryl-substituted alkynes and NbCl3(DME) in 1,2-dichloroethane under reflux conditions.
Obora
Yasushi
Y
Catalysis Research Center and Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, 001-0021, Japan.
Kimura
Masahiro
M
Tokunaga
Makoto
M
Tsuji
Yasushi
Y
D000480:Alkynes / Q000737:chemistry*; D005025:Ethylene Dichlorides / Q000737:chemistry; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009556:Niobium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*
D000480:Alkynes; D005025:Ethylene Dichlorides; D007192:Indenes; D007659:Ketones; D009942:Organometallic Compounds; D009556:Niobium; C024565:ethylene dichloride