Cellular and molecular facets of keratinocyte reepithelization during wound healing.
Cutaneous wound healing is a highly coordinated physiological process that rapidly and efficiently restores skin integrity. Reepithelization is a crucial step during wound healing, which involves migration and proliferation of keratinocytes to cover the denuded dermal surface. Recent advances in wound biology clarified the molecular pathways governing keratinocyte reepithelization at wound sites. These new findings point towards novel therapeutic targets and provide suitable methods to promote faster tissue regeneration in vivo.
Santoro
Massimo M
MM
Department of Medical Sciences, University of Piemonte Orientale A. Avogadro, Via Solaroli 17, 28100 Novara, Italy. msantoro@unipmn.it
Gaudino
Giovanni
G
D000818:Animals; D002465:Cell Movement; D049109:Cell Proliferation; D004848:Epithelium / Q000378:metabolism / Q000502:physiology*; D016023:Integrins / Q000378:metabolism; D015603:Keratinocytes / Q000502:physiology*; D014945:Wound Healing
D016023:Integrins