Effects of high-energy shock wave on organs adjacent to the kidney in the growing rat.
OBJECTIVE
To assess the effects of high-energy shock waves (HESW) on organs adjacent to the kidney, in the growing rat.


METHODS
We studied 60 Wistar male rats. Upon completing 30 days of age, a radiopaque marker was placed in the animals' left renal cavity. With 40 days of age, after radiologically confirming the markers' position, the rats were divided into 2 groups: control-group--30 rats that did not receive shock waves; experimental group--30 rats exposed to 1000 shock waves of 17.2 KV in intensity. The rats were sacrificed 7, 90 and 180 days after exposure to HESW. The bodily growth was assessed and the analysis of macro- and microscopic morphology of liver, spleen, pancreas, lungs and adrenals.


RESULTS
There was no statistical difference in the animals' bodily growth. The microscopic morphologic analysis demonstrated significant alterations in spleen (proliferative changes in the red pulp) and liver (cloudy swelling) of the animals submitted to HESW and sacrificed on the seventh day. These changes completely disappeared in subsequent analyses.


CONCLUSIONS
HESW applied to rat did not inhibit the animals' growth and caused transitory histological lesion in spleen (proliferative changes in the red pulp) and in liver (cloudy swelling of hepatocytes). Such changes were observed only in the group that was exposed to HESW and was sacrificed 7 days following the experiment, presenting spontaneous recovery.
Nardi
Aguinaldo C
AC
Department of Surgery, School of Medicine, State University of Campinas, UNICAMP, Campinas, SP, Brazil.
Ferreira
Ubirajara
U
Claro
Joaquim A
JA
Stopiglia
Gustavo M
GM
Netto
N Rodrigues
NR
D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D006128:Growth; D008096:Lithotripsy / Q000009:adverse effects*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D010179:Pancreas / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000473:pathology