title: Antifungal metabolites from Blumea balsamifera.
abstract: The leaves of Blumea balsamifera afforded icthyothereol acetate, cryptomeridiol, lutein, and beta-carotene. The structures of icthyothereol acetate (1) and cryptomeridiol (2) were elucidated by extensive 1D and 2D NMR spectroscopy, while those of lutein and beta-carotene were identified by comparison with literature data. Antimicrobial tests indicated that 1 has moderate activity against the fungi Aspergillus niger, Trichophyton mentagrophytes, and Candida albicans, while 2 has low activity against A. niger, T. mentagrophytes, and C. albicans. Both compounds have no antimicrobial activity against Psuedomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, and Escherichia coli.
authors.affiliation: Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila 1004, Philippines. ragasac@dlsu.edu.ph
authors.forename: Consolacion Y
authors.initials: CY
authors.lastname: Ragasa
authors.forename: Angel Lyn Kristin C
authors.initials: AL
authors.lastname: Co
authors.forename: John A
authors.initials: JA
authors.lastname: Rideout
mesh_terms: D000480:Alkynes / Q000302:isolation & purification* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000480:Alkynes; D009281:Naphthalenes; D010936:Plant Extracts; D011714:Pyrans; C499954:cryptomeridiol; C499953:icthyothereol acetate