title: Magnetic resonance perfusion tracks 133Xe cerebral blood flow changes after carotid stenting.
abstract: OBJECTIVE
  To compare magnetic resonance (MR) perfusion to gold-standard cerebral blood flow (CBF) determined by intra-arterial (133)Xe washout method.
  
  
  METHODS
  Eight patients with high-grade carotid stenoses underwent bolus-tracking MR perfusion and intra-arterial (133)Xe washout before and after carotid stenting. MR perfusion was compared with 133Xe-CBF values using Pearson linear correlation analysis.
  
  
  RESULTS
  We observed a mean 37+/-38% increase in 133Xe-CBF and a mean 19+/-27% increase in relative CBF (rCBF) by MR perfusion immediately after stent placement. Relative (percent) changes in MR-rCBF showed a close and linear correlation to those seen in 133Xe-CBF (r=0.91; R2=0.84; P=0.002). There was a trend for MR perfusion to underestimate change in CBF at higher relative changes in flow.
  
  
  CONCLUSIONS
  Bolus-tracking MR perfusion correlates with 133Xe-CBF in estimating postprocedural increases in blood flow but may underestimate the magnitude of the change with higher relative changes.
authors.affiliation: Department of Neurology, University of California, San Francisco, USA.
authors.forename: Nerissa U
authors.initials: NU
authors.lastname: Ko
authors.forename: Achal S
authors.initials: AS
authors.lastname: Achrol
authors.forename: Alastair J
authors.initials: AJ
authors.lastname: Martin
authors.forename: Manju
authors.initials: M
authors.lastname: Chopra
authors.forename: David A
authors.initials: DA
authors.lastname: Saloner
authors.forename: Randall T
authors.initials: RT
authors.lastname: Higashida
authors.forename: William L
authors.initials: WL
authors.lastname: Young
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D016893:Carotid Stenosis; D002560:Cerebrovascular Circulation; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015607:Stents; D014980:Xenon Radioisotopes / Q000032:analysis*
chemical_list: D014980:Xenon Radioisotopes