title: Does needle size matter? Patient experience of luteinising hormone-releasing hormone analogue injection.
abstract: To determine whether needle size influences a patient's perception of pain, 50 patients requiring hormonal manipulation for prostate cancer were blindfolded and randomised to receive two goserelin ('Zoladex') or two leuprorelin ('Prostap') injections, using 16- or 23-gauge needles, respectively. Median visual analogue scale pain scores for the first injections of goserelin and leuprorelin were below the level of clinical significance and were not statistically different. Mean administration time for goserelin was significantly shorter than for leuprorelin. In conclusion, there was no statistically significant difference in pain experienced on injection of goserelin and leuprorelin when patients were unaware of needle size.
authors.affiliation: Department of Urology, Frimley Park Hospital NHS Trust, Camberley, Surrey GU16 5UJ, UK. bmontgo@btconnect.com
authors.forename: B S I
authors.initials: BS
authors.lastname: Montgomery
authors.forename: J P
authors.initials: JP
authors.lastname: Borwell
authors.forename: D M
authors.initials: DM
authors.lastname: Higgins
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D017273:Goserelin / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009339:Needles; D010146:Pain; D010147:Pain Measurement; D017060:Patient Satisfaction; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D016037:Single-Blind Method
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin; D016729:Leuprolide