title: Devastating presentations of regional enteritis (Crohn's disease): two reports of survival following severe multiple organ dysfunction syndrome.
abstract: BACKGROUND
  Regional enteritis may present in the setting of a variety of clinical symptoms. These symptoms range from mild to severe.
  
  
  METHODS
  Here we describe two different presentations of regional enteritis (Crohn's disease): one in the setting of Clostridium perfringens sepsis and the second in association with hemolytic-uremic syndrome. Both presentations resulted in life-threatening multiple organ dysfunction syndrome.
  
  
  RESULTS
  Following appropriate surgical management and intensive physiologic support, both patients recovered, despite a MODS-predicted risk of mortality of 100% and 91%, respectively.
  
  
  CONCLUSIONS
  Fulminant presentations of regional enteritis of this magnitude are rare, and highlight the resolution of severe multiple organ dysfunction for each presentation.
authors.affiliation: Department of Surgery, Division of Critical Care and Trauma, Weill Medical College of Cornell University, New York, New York, USA.
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Grossman
authors.forename: Lynn J
authors.initials: LJ
authors.lastname: Hydo
authors.forename: John C L
authors.initials: JC
authors.lastname: Wang
authors.forename: Mark
authors.initials: M
authors.lastname: Pochapin
authors.forename: Philip S
authors.initials: PS
authors.lastname: Barie
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents; D001774:Blood Chemical Analysis; D003015:Clostridium Infections / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D016638:Critical Illness; D003424:Crohn Disease / Q000175:diagnosis* / Q000628:therapy*; D018450:Disease Progression; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007813:Laparotomy / Q000379:methods; D008297:Male; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000628:therapy*; D018570:Risk Assessment; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis* / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents