title: Bacterial toxins and the immune system: show me the in vivo targets.
abstract: Microorganisms that cause persistent infection often exhibit specific adaptations that allow them to avoid the adaptive immune response. Recently, several bacterial toxins have been shown in vitro to disrupt immune cell functions. However, it remains to be established whether these activities are relevant during infection and whether these toxins have specifically evolved to disrupt the adaptive immune system.
authors.affiliation: Yale University School of Medicine, New Haven, CT 06536, USA. jorge.galan@yale.edu
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Galán
mesh_terms: D001408:Bacillus anthracis / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D001427:Bacterial Toxins / Q000276:immunology*; D002460:Cell Line; D006801:Humans; D007107:Immune System / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D015007:Yersinia; D015011:Yersinia pseudotuberculosis / Q000276:immunology
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins