title: Denervation-induced spatiotemporal upregulation of ephrin-A2 in the mouse hippocampus after transections of the perforant path.
abstract: Transections of the entorhinal afferent fibers to hippocampus, perforant path (PP), result in the denervation in specific hippocampal subregions, which is followed by a series of plastic events including axon sprouting and reactive synaptogenesis. Many growth-associated molecules are thought to participate in these events. In the present study, we proved the upregulation of ephrin-A2 in the denervated areas of the ipsilateral hippocampus following PP transections. Interestingly, when the elevation of ephrin-A2 reached the maximum axon sprouting in the denervated areas almost finished, implying the possible inhibitory effect of ephrin-A2 on sprouting. In addition, ephrin-A2 expression was observed in synapses during reactive synaptogenesis, suggesting that this molecule might also be implicated in the formation and maturation of synapses in the denervated areas.
authors.affiliation: Key Laboratory of Neurobiology, Shanghai Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Zi-Mei
authors.initials: ZM
authors.lastname: Ni
authors.forename: Chang-Fu
authors.initials: CF
authors.lastname: Zhou
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003714:Denervation; D036383:Ephrin-A2 / Q000378:metabolism*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism* / Q000601:surgery*; D007150:Immunohistochemistry; D051379:Mice; D008813:Mice, Inbred ICR; D019580:Perforant Pathway / Q000502:physiology*; D013569:Synapses / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D036383:Ephrin-A2; D005904:Glial Fibrillary Acidic Protein