title: Costal-2: a scaffold for kinases mediates Hedgehog signaling.
abstract: Drosophila genetics has identified several components of the Hedgehog signaling pathway, but the mechanism by which they act remains elusive. In this issue of Developmental Cell, a report by Zhang et al. provides evidence that the kinesin-related protein Costal-2 forms a multi-component scaffold that mediates Hedgehog signaling.
authors.affiliation: Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ishii
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D029721:Drosophila Proteins / Q000502:physiology*; D053823:Hedgehog Proteins; D016547:Kinesins / Q000502:physiology*; D011494:Protein Kinases / Q000502:physiology; D015398:Signal Transduction
chemical_list: D029721:Drosophila Proteins; D053823:Hedgehog Proteins; C107452:cos protein, Drosophila; C077245:hh protein, Drosophila; D011494:Protein Kinases; D016547:Kinesins