Absence of teratogenicity of sirolimus used during early pregnancy in a liver transplant recipient.
We describe the case of successful delivery in a 21-year-old woman who became pregnant 3 years after liver transplantation and who received sirolimus during the first 6 weeks of gestation. Sirolimus was discontinued when ultrasonography revealed a pregnancy, she was switched to tacrolimus and prednisone was continued. The course of pregnancy was uneventful; there were no signs or symptoms of graft rejection. Due to fetal intrauterine threatening asphyxia the pregnancy was concluded by cesarean section in the 39th gestational week, delivering a healthy, 2950 g, Apgar 10, female infant.
Jankowska
I
I
Department of Gastroenterology, Hepatology and Immunology, The Children's Memorial Health Institute, Warsaw, Poland.
Oldakowska-Jedynak
U
U
Jabiry-Zieniewicz
Z
Z
Cyganek
A
A
Pawlowska
J
J
Teisseyre
M
M
Kalicinski
P
P
Markiewicz
M
M
Paczek
L
L
Socha
J
J
D000328:Adult; D001034:Apgar Score; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007231:Infant, Newborn; D016031:Liver Transplantation / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D011256:Pregnancy Outcome; D020123:Sirolimus / Q000009:adverse effects / Q000627:therapeutic use*; D013723:Teratogens
D007166:Immunosuppressive Agents; D013723:Teratogens; D020123:Sirolimus