title: Seminoma with hyperesterogenemia in a Yorkshire Terrier.
abstract: A male 8-year-old Yorkshire Terrier dog with unilateral cryptorchism was presented for investigation of reduced appetite and multifocal alopecia. Abdominal sonography and radiography demonstrated abnormal enlargement of left testicle in abdominal cavity. Both of the retroperitoneal cryptorchid testicle and the other contralateral testicle were removed surgically. The concentrations of testosterone and estradiol in blood collected from the jugular vein and the two spermatic veins were evaluated and the results revealed high estradiol concentration. The retroperitoneal cryptorchid testicle was enlarged, firm, bulging sphere mass. The cut surface revealed homogeneous white color and lobulation by septa. The contralateral testicle in scrotum showed atrophic testicle and enlarged epididymis. Histopathologically, the retroperitoneal cryptorchid testicle was diagnosed as seminoma. We thought that hyperesterogenemia and alopecia in this case was probably related with his seminoma, although high correlations between Sertoli cell tumor and alopecia have been reported. To our knowledge, this report may be a rare case of seminoma with hyperesterogenemia and alopecia.
authors.affiliation: Department of Laboratory Animal Sciences, College of Medicine, Seoul National University, South Korea.
authors.forename: Okjin
authors.initials: O
authors.lastname: Kim
authors.forename: Kyung-Suk
authors.initials: KS
authors.lastname: Kim
mesh_terms: D000505:Alopecia / Q000209:etiology / Q000662:veterinary; D000818:Animals; D003456:Cryptorchidism / Q000150:complications / Q000662:veterinary; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D004967:Estrogens / Q000097:blood*; D008297:Male; D018239:Seminoma / Q000097:blood / Q000150:complications / Q000662:veterinary*; D013736:Testicular Neoplasms / Q000097:blood / Q000150:complications / Q000662:veterinary*
chemical_list: D004967:Estrogens