title: Bone morphogenetic protein-mediated type II collagen expression in pilomatricoma and cutaneous mixed tumor.
abstract: BACKGROUND
  We have previously reported that type II collagen deposition in overlying dermo-epidermal junction (DEJ) of pilomatricoma is mediated by bone morphogenetic protein 2/4 (BMP 2/4) expressed by shadow cells (SCs) of pilomatricoma.
  
  
  OBJECTIVE
  This time, we studied the expression of type II collagen and BMP in a large number of cases of pilomatricoma and extended our study to cutaneous mixed tumor (CMT).
  
  
  RESULTS
  We found type II collagen deposition in the overlying DEJ (16 of 50 cases) and in the SCs (19/50) of pilomatricoma. The number of case of type II collagen deposition in DEJ (DEJ(+)) and in SCs (SC(+)) of pilomatricoma correlated to the chronological stage of pilomatricoma. We also found type II collagen deposition in overlying DEJ (two of 11) and in the stromal chondroid tissue (four of 11) of CMT. BMP 2 was expressed in most cases of pilomatricoma (37/50) and CMT (seven of 11).
  
  
  CONCLUSIONS
  The expression of type II collagen in pilomatricoma is dependent upon the chronological stage of pilomatricoma. Type II collagen expression in the overlying DEJ and chondroid matrix in CMT may be induced by BMP via the same mechanism as in pilomatricoma.
authors.affiliation: Department of Dermatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. srg1937@gr.ndmc.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Mieno
authors.forename: Kei
authors.initials: K
authors.lastname: Kuroda
authors.forename: Shingo
authors.initials: S
authors.lastname: Tajima
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D002648:Child; D024043:Collagen Type II / Q000378:metabolism*; D020405:Dermis / Q000378:metabolism / Q000473:pathology; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D005260:Female; D006201:Hair Diseases / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007365:Intercellular Junctions / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018198:Mixed Tumor, Malignant / Q000378:metabolism* / Q000473:pathology; D018296:Pilomatrixoma / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D019485:Bone Morphogenetic Proteins; D024043:Collagen Type II