[Possibility that AMF will serve as a target molecule for the diagnosis and treatment of a metastatic neoplasm].
The Autocrine Motility Factor (AMF) identified as a tumor cell motile stimulation factor is a key molecule of invasion and metastasis. The AMF is also identified as neuroleukin (NLK) and maturation factor (MF) which are secreted phosphohexose isomerase (PHI, PGI) from anaplastic cells. Tumor AMF promotes cellular locomotion or invasion, and regulates tumor MMPs secretion or apoptotic resistance. The AMF was thought to be an autocrine factor as the name shows it, and it is peculiar to malignant cells. However we found paracrine effect of AMF against tumor surrounding host tissues. Especially, endothelial cells which are essential parts of tumor induced angiogenesis or ascites accumulation express the AMF-receptor and they responded to AMF stimulation. Metastasis is a most complicated biological phenomenon that a large number of molecules or factors induced by tumor and host are related, thus AMF is also unusual molecule reacting between tumor and host tissues, and therefore AMF should be a target of treatment or diagnosis of cancer.
Haga
Arayo
A
Department of Hygienics, Gifu Pharmaceutical University, Gifu 502-8585, Japan. arayo@gifu-pu.ac.jp
D000818:Animals; D002465:Cell Movement; D005956:Glucose-6-Phosphate Isomerase / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D011487:Protein Conformation; D060285:Receptors, Autocrine Motility Factor; D018121:Receptors, Cytokine / Q000378:metabolism; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases
D018121:Receptors, Cytokine; C555000:AMFR protein, human; D060285:Receptors, Autocrine Motility Factor; D044767:Ubiquitin-Protein Ligases; D005956:Glucose-6-Phosphate Isomerase