title: Mechanisms of cancer metastasis to the bone.
abstract: Some of the most common human cancers, including breast cancer, prostate cancer, and lung cancer, metastasize with avidity to bone. What is the basis for their preferential growth within the bone microenvironment? Bidirectional interactions between tumor cells and cells that make up bone result in a selective advantage for tumor growth and can lead to bone destruction or new bone matrix deposition. This review discusses our current understanding of the molecular components and mechanisms that are responsible for those interactions.
authors.affiliation: Cell and Cancer Biology Branch, NCI, NIH, Bethesda, MD 20892, USA.
authors.forename: Juan Juan
authors.initials: JJ
authors.lastname: Yin
authors.forename: Claire B
authors.initials: CB
authors.lastname: Pollock
authors.forename: Kathleen
authors.initials: K
authors.lastname: Kelly
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000556:secondary*; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism