title: [Vaccination failure: case report of Haemophilus influenzae b meningitis in a 14-month-old child].
abstract: BACKGROUND
  The generalization of the vaccination against H. influenzae b (Hib), according to its integration in the French vaccinal calendar, led to the incidence decrease of the purulent meningitis with Hib in young children, which became a so rare event.
  
  
  METHODS
  We described the case of a 14-months-old child showing a bacterial purulent meningitis with Hib, despite of a well driven vaccination.
  
  
  CONCLUSIONS
  The epidemiology of bacterial meningitis was upset by the generalization of the anti-H. influenzae b vaccination. The use of combined vaccines specially reduced the incidence and the gravity of this pathology. Nevertheless, in spite of the excellent vaccinal coverage, the limited but real persistence of epiglottis or meningitis due to H. influenzae b should keep in mind of the biologists and the clinicians. Indeed, the chronic nasopharyngal carriage, the existence of not vaccinated or not answering people allow to consider the persistent risk of H. influenzae b bacterial meningitis.
authors.affiliation: Laboratoire de Bactériologie-Virologie-Hygiène Hospitalière, institut de biologie de Nantes, CHU de Nantes, 9 quai Moncousu, 44093 Nantes cedex 01, France. stephane.corvec@chu-nantes.fr
authors.forename: S
authors.initials: S
authors.lastname: Corvec
authors.forename: I
authors.initials: I
authors.lastname: Hazart
authors.forename: A
authors.initials: A
authors.lastname: Reynaud
authors.forename: G
authors.initials: G
authors.lastname: Picherot
authors.forename: H
authors.initials: H
authors.lastname: Drugeon
mesh_terms: D018073:Haemophilus Vaccines / Q000009:adverse effects*; D019741:Haemophilus influenzae type b / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D008583:Meningitis, Haemophilus / Q000276:immunology*; D017211:Treatment Failure
chemical_list: D018073:Haemophilus Vaccines