[Research progress of neuroprotective mechanisms of Gastrodia elata and its preparation].
The effects of Gastrodia elata on preventing decrepitude and advancing memory are closely associated with its neuroprotective activity. Previous researches proved that G. elata, its active components and preparations played a neuroprotective role by affecting the excitotoxicity, nitric monoxide (NO) system, neuroglia, biomembrane, oxidative neurotoxicity, apoptosis et al. Recent researches also suggest that reducing energy metabolism impairment, anti-inflammatory and immune modulating function may be new research targets of neuroprotective mechanism of G. elata.
Sun
Xiao-fang
XF
Geriatrics Institute, Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091, China. sxfnet@sina.com
Wang
Wei
W
Wang
Dan-qiao
DQ
Du
Gui-you
GY
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D018846:Excitatory Amino Acids / Q000037:antagonists & inhibitors; D031668:Gastrodia / Q000737:chemistry; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D018846:Excitatory Amino Acids; D018696:Neuroprotective Agents; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D002118:Calcium