Absence of surface CD27 distinguishes hairy cell leukemia from other leukemic B-cell malignancies.
Surface expression of CD27 was evaluated in 75 mature leukemic B-cell neoplasms. All cases other than hairy cell leukemia (HCL) expressed CD27. Intensity was significantly higher in chronic lymphocytic leukemia. Lack of CD27 in 17/17 HCL contrasted with expression of this marker in 5/5 splenic lymphomas with villous lymphocytes. Lack of CD27 is a new distinctive feature of HCL among B-cell malignancies.
Forconi
Francesco
F
Raspadori
Donatella
D
Lenoci
Mariapia
M
Lauria
Francesco
F
D001402:B-Lymphocytes / Q000378:metabolism; D014408:Biomarkers, Tumor; D002462:Cell Membrane / Q000378:metabolism; D003937:Diagnosis, Differential; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000378:metabolism*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7