title: Paracentric inversion of chromosome 7(q22-31) associated with nonobstructive azoospermia.
abstract: OBJECTIVE
  To examine an unusual paracentric inversion of chromosome 7 found in an azoospermic man.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Infertility clinic at a private hospital.
  
  
  METHODS
  An azoospermic but otherwise apparently healthy man.
  
  
  METHODS
  Karyotyping with peripheral blood lymphocytes, microdissection testicular sperm extraction (TESE), and intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  Sperm count and GBG banding.
  
  
  RESULTS
  A karyogram revealed paracentric inversion of chromosome 7 with breakpoints at 7q22 and 7q31. Testicular histopathology confirmed the Sertoli cell-only syndrome. Successful pregnancy and delivery were achieved with microdissection TESE and ICSI.
  
  
  CONCLUSIONS
  Paracentric inversion of chromosome 7(q22-31) associated with nonobstructive azoospermia is rare. Chromosome 7q22-31 may be responsible for impaired spermatogenesis.
authors.affiliation: Department of Urology, Kurashiki Central Hospital, Okayama, Japan. ki7528@kchnet.or.jp
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ichioka
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Honda
authors.forename: Akira
authors.initials: A
authors.lastname: Takahashi
authors.forename: Akito
authors.initials: A
authors.lastname: Terai
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*