Airway epithelial cell release of cytokines: modulation by various therapeutic agents.
The airway epithelial cell plays a central role in asthma pathogenesis and potential remodeling in secreting numerous cytokines, growth factors, chemokines, and nitric oxide. The role of various therapeutic agents on in vivo and in vitro antigen, growth factor, and respiratory syncytial virus-stimulated human small airway bronchial and alveolar epithelial cells will be reviewed. The experimental studies presented here, which used human airway epithelial cell cultures, may identify new therapeutic options in preventing amplified airway inflammation and remodeling in a subset of asthmatic or bronchiolitis patients with an atopic pre-disposition.
Frieri
Marianne
M
Division of Allergy Immunology, Departments of Medicine, Pediatrics, and Pathology, Nassau University Medical Center, East Meadow, NY 11554, USA.
D000293:Adolescent; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy* / Q000276:immunology; D018925:Chemokines / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000187:drug effects / Q000378:metabolism*; D004847:Epithelial Cells / Q000187:drug effects* / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D011336:Probability; D011379:Prognosis; D012137:Respiratory System; D012680:Sensitivity and Specificity
D018927:Anti-Asthmatic Agents; D018925:Chemokines; D016207:Cytokines; D018836:Inflammation Mediators