[Expressions of Abeta1-40, Abeta1-42, tau202, tau396 and tau404 after intracerebroventricular injection of streptozotocin in rats].
OBJECTIVE
To investigate the effects of intracerebroventricular (ICV) administration of streptozotocin (STZ) on the expressions of Abeta and hyperphosphorylation of tau protein in rat brain.


METHODS
Twenty-four adult SD rats were randomized into 2 groups to receive ICV of STZ bilaterally at the dose of 3 mg/kg (with the injection repeated on day 3) or normal saline injection in an identical manner. Twenty-one days later, the expressions of Abeta(1-40), Abeta(1-42), tau(202), tau(396) and tau(404) were investigated immunohistochemically.


RESULTS
After STZ administration, the expressions of Abeta(1-40), Abeta(1-42), tau(202), tau(396) and tau(404) increased in both the cortex and hippocampus in the rat brain.


CONCLUSIONS
ICV injection of STZ increases the expression of Abeta and promotes hyerphosphorylation of tau protein.
Chu
Wen-Zheng
WZ
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. bzchu@yahoo.com.cn
Qian
Cai-Yun
CY
D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D001921:Brain / Q000378:metabolism; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D013311:Streptozocin / Q000494:pharmacology*; D016875:tau Proteins / Q000096:biosynthesis* / Q000235:genetics
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D013311:Streptozocin