title: Custom-made stent-grafts for aortic aneurysm repair using gianturco Z stents and woven polyester: healing in an animal model.
abstract: The purpose of this study was to evaluate the healing at 6 months of aortic stent-grafts custom-made by using Z stents and woven polyester in an animal model. Stent-grafts were built by a published method using autoexpandable stainless steel stents continuously compiled with polyester sutures and covered with a woven polyester membrane. Fourteen stent-grafts of 3 different designs were deployed under fluoroscopic control into the thoracic and the abdominal aorta of 7 adult sheep. At 6 months, all the implants of the sheep that survived the implantation were angiographed and harvested for macroscopy and microscopy. All stent-grafts were implanted successfully and remained patent from then to the explantation procedure. All stent-grafts implanted among the 6 of 7 (86%) animals that survived after the implantation remained patent, stayed free from local complications, and did not migrate during more than 6 months. In all these cases during this period, the implant functioned as a satisfactory aortic substitute while the aortic segment containing the graft kept a normal structure. There was no adverse effects of the presence of the implant upon the aorta or the animal. Stent-grafts home-made according to the described methods gave results at 6 months in this animal model compatible with a safe clinical application among humans.
authors.affiliation: Department of Vascular Surgery, CHU Pitié-Salpêtrière, Paris, France. fabien.koskas@psl.ap-hop-paris.fr
authors.forename: Fabien
authors.initials: F
authors.lastname: Koskas
authors.forename: Isabelle
authors.initials: I
authors.lastname: Brocheriou
authors.forename: Philippe
authors.initials: P
authors.lastname: Cluzel
authors.forename: Jean-Dominique
authors.initials: JD
authors.lastname: Singland
authors.forename: Bruno
authors.initials: B
authors.lastname: Régnier
authors.forename: Michel
authors.initials: M
authors.lastname: Bonnot
authors.forename: Edouard
authors.initials: E
authors.lastname: Kieffer
mesh_terms: D000818:Animals; D001011:Aorta / Q000503:physiopathology* / Q000601:surgery; D001018:Aortic Diseases / Q000209:etiology; D001672:Biocompatible Materials / Q000009:adverse effects; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects; D023421:Models, Animal; D011091:Polyesters / Q000009:adverse effects; D012756:Sheep; D015607:Stents / Q000009:adverse effects; D014945:Wound Healing / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters