Reformulating and simplifying the DF analysis model.
DeFries-Fulker (DF) Analysis for unselected populations is reformulated as a no-intercept model with centered variables and only two independent variables. The reformulation serves three purposes. First, the original formulation implicitly estimated two different values for c2 and two values for h2. The new formulation resolves this ambiguity. Second, because the original formulation estimated h2 with the coefficient from a regression-interaction term, whether to center the interaction variables was unclear. The new formulation explicitly resolves this issue. Finally, the new formulation estimates fewer parameters, and therefore improves estimation efficiency and statistical power.
Lee Rodgers
Joseph
J
Department of Psychology, University of Oklahoma, Norman, OK 73019, USA. Jrodgers@ou.edu
Kohler
Hans-Peter
HP
D005298:Fertility / Q000235:genetics; D006801:Humans; D016018:Least-Squares Analysis; D008957:Models, Genetic; D008960:Models, Psychological; D012044:Regression Analysis; D018433:Twin Studies as Topic