Effect of lecithin-bound iodine on the patients with bronchial asthma.
Lecithin-bound iodine (LBI), which has been reported to be a potential candidate for one of the therapeutic modalities for children with bronchial asthma based on the in-vitro study, was also found to be effective in relieving the symptoms of patients with childhood asthma. In addition to the in-vitro effect of downregulation and upregulation of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma), respectively, the clinical effect of LBI was highlighted through the concomitant upregulation of IFN-gamma production by the patients' lymphocytes, which were treated with LBI for 8 weeks. Therefore, LBI may reduce the signs of bronchial asthma by upregulating the synthesis of IFN-gamma that is a representative Th1 cytokine.
Kawano
Yutaka
Y
Department of Pediatrics, Kitasato University, Japan. kawanoyutaka@mbj.ocn.ne.jp
Saeki
Toshiaki
T
Noma
Takeshi
T
D001249:Asthma / Q000188:drug therapy* / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D007371:Interferon-gamma / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D007455:Iodine / Q000494:pharmacology* / Q000627:therapeutic use; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology* / Q000627:therapeutic use
D007155:Immunologic Factors; D010713:Phosphatidylcholines; D015847:Interleukin-4; C036559:lecithin-bound iodine; D007371:Interferon-gamma; D007455:Iodine