title: Whole blood and red blood cell manganese reflected signal intensities of T1-weighted magnetic resonance images better than plasma manganese in liver cirrhotics.
abstract: We examined whole blood (MnB), red blood cell (MnRBC), plasma (MnP) and urinary Mn (MnU) concentrations in 22 liver cirrhotics and 10 healthy controls to evaluate Mn concentration in which a fraction of biological samples best reflects pallidal signal intensities (pallidal index; PI) on T1-weighted magnetic resonance images (MRI) in liver cirrhotics. Increased signal intensity in the globus pallidus was observed in 18 (81.8%) of the 22 patients with liver cirrhosis. In a transplanted patient, increased pallidal signals also resolved as his liver function tests normalized after liver transplantation. There were significant correlations between MnB/MnRBC and PI (rho=0.529, rho=0.573, respectively) in liver cirrhotics, although no significant correlation was observed between MnP/MnU and PI. According to a multiple linear regression, MnB and MnRBC reflected the signal intensities of T1-weighted MRI better than MnP or MnU.
authors.affiliation: Department of Occupational and Environmental Medicine, Ulsan University Hospital, South Korea.
authors.forename: Younghee
authors.initials: Y
authors.lastname: Choi
authors.forename: Ji Kang
authors.initials: JK
authors.lastname: Park
authors.forename: Neung Hwa
authors.initials: NH
authors.lastname: Park
authors.forename: Jung Woo
authors.initials: JW
authors.lastname: Shin
authors.forename: Cheol-In
authors.initials: CI
authors.lastname: Yoo
authors.forename: Choong Ryeol
authors.initials: CR
authors.lastname: Lee
authors.forename: Hun
authors.initials: H
authors.lastname: Lee
authors.forename: Hyo Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Sung-Ryul
authors.initials: SR
authors.lastname: Kim
authors.forename: Tae-Hum
authors.initials: TH
authors.lastname: Jung
authors.forename: Jungsun
authors.initials: J
authors.lastname: Park
authors.forename: Chung Sik
authors.initials: CS
authors.lastname: Yoon
authors.forename: Yangho
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004912:Erythrocytes / Q000737:chemistry*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008345:Manganese / Q000097:blood*; D008875:Middle Aged
chemical_list: D008345:Manganese