title: Mandibular bone deficit with a histologic study in man.
abstract: The aim of this study was that to determine the clinical and histologic results of a new hydroxyapatite, with innovative properties compared with the other alloplastic materials used in the regenerative treatment of grade 3 bony defects of the mandibular furcations in the human. The hydroxyapatite used in our research is characterized by a scarce density and crystallinity, while from a microstructural point of view, the granules have nanometric dimensions (0.05-0.1 microm). The patient reported here by the authors had a grade 3 infrabony defect into a mandibular furcation. The surgical procedure used consists of the creation of a flap, roots planing, the conditioning of the roots with tetracycline HC, the accurate positioning of the granules of the hydroxyapatite in the furcation area, the crown replacing of the flap, and finally the suture of the same. Six months after the insertion of hydroxyapatite, the clinical effect was studied, comparing the variations found in probing the insertion of depth. At the end of the treatment, a block section of the molar was performed, with part of the surrounding soft tissues, whose histologic analysis underlined the moderate and initial formation of bony tissue, periodontal ligament, and radicular cement in the middle and lower portion of the furcation. In light of these results, the authors conclude that the use of this new hydroxyapatite is promising in the treatment of the mandibular furcations in the human, even if it will be necessary to continue to test its effectiveness through more studies.
authors.affiliation: Department of Dental Prosthesis, Faculty of Medicine, University of Catania, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Pappalardo
authors.forename: Orazio A
authors.initials: OA
authors.lastname: Baglio
authors.forename: Roberto F
authors.initials: RF
authors.lastname: Grassi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Grivetto
authors.forename: Carmen
authors.initials: C
authors.lastname: Mortellaro
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D017886:Durapatite / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008336:Mandibular Diseases / Q000601:surgery*; D008963:Molar; D016745:Root Planing; D013524:Surgical Flaps; D013536:Suture Techniques; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D018786:Bone Substitutes; D017886:Durapatite; D013752:Tetracycline