Application of Mosher's method for absolute configuration assignment and resolution of 2-hydroxypyrrolizidinones.
Derivatization of racemic 2-hydroxypyrrolizidinones with S-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (MTPA-Cl) was successfully used for enantiomer separation and absolute configuration assignment.
Cordero
Franca M
FM
Dipartimento di Chimica Organica U. Schiff, Università degli Studi di Firenze, Italy. franca.cordero@unifi.it
Pisaneschi
Federica
F
Salvati
Maria
M
Valenza
Silvia
S
Faggi
Cristina
C
Brandi
Alberto
A
D003461:Crystallography; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010648:Phenylacetates / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry*; D013237:Stereoisomerism
D010648:Phenylacetates; D011760:Pyrrolidinones; C101363:alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride