title: Cytotoxic activities of chitosan nanoparticles and copper-loaded nanoparticles.
abstract: Chitosan nanoparticles and copper(II)-loaded chitosan nanoparticles were prepared based on the ionic gelation of chitosan with tripolyphosphate anions and copper ion sorption. In this study, the cytotoxic activities of the chitosan nanoparticles and copper(II)-loaded chitosan nanoparticles was investigated and a relationship between physiochemical properties and activity is suggested. The chitosan nanoparticles and copper(II)-loaded chitosan nanoparticles elicited dose-dependent inhibitory effects on the proliferation of tumor cell lines.
authors.affiliation: Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Animal Science college, Zhejiang University, Hangzhou 310029, PR China. lfqi@zju.edu.cn
authors.forename: Lifeng
authors.initials: L
authors.lastname: Qi
authors.forename: Zirong
authors.initials: Z
authors.lastname: Xu
authors.forename: Xia
authors.initials: X
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Minqi
authors.initials: M
authors.lastname: Wang
mesh_terms: D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D048271:Chitosan / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003300:Copper / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects; D008113:Liver Neoplasms / Q000188:drug therapy*; D049329:Nanostructures / Q000737:chemistry / Q000633:toxicity*; D010316:Particle Size; D013274:Stomach Neoplasms / Q000188:drug therapy*
chemical_list: D003300:Copper; D048271:Chitosan