Acaricidal daphnane diterpenoids from Trigonostemon reidioides (KURZ) CRAIB roots.
A new daphnane diterpenoid, rediocide F (1), was isolated together with three known compounds, rediocides A (2), C (3) and E (4), from the hexane extract of Trigonostemon reidioides roots by bioassay-guided fractionation for acaricidal activity on Dermatophagoides pteronyssinus, Thai common house dust mite. The structure of rediocide F (1) was established as the demethyl analog of rediocide C (3) on the basis of spectral analysis. Compounds 1-4 exhibited potent activity against D. pteronyssinus with respective LC50 values of 2.53, 0.78, 5.59 and 0.92 microg/cm2.
Soonthornchareonnon
Noppamas
N
Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. pynsk@mahidol.ac.th
Sakayarojkul
Monnun
M
Isaka
Masahiko
M
Mahakittikun
Vanna
V
Chuakul
Wongsatit
W
Wongsinkongman
Prapai
P
D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D007306:Insecticides / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D039981:Pyroglyphidae / Q000502:physiology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D004224:Diterpenes; D007306:Insecticides; C011309:mezerein