title: Histological progression of non-alcoholic fatty liver disease in Chinese patients.
abstract: BACKGROUND
  Non-alcoholic fatty liver disease is an important cause of chronic hepatitis and cryptogenic cirrhosis. The natural history of non-alcoholic fatty liver disease is not well understood especially in Asian populations.
  
  
  OBJECTIVE
  To investigate the histological progression in Chinese patients with biopsy-proven non-alcoholic fatty liver disease.
  
  
  METHODS
  Chinese patients who had liver biopsy at least 3 years ago and confirmed to have non-alcoholic fatty liver disease were invited for a second liver biopsy. Clinical and laboratory parameters related to their liver function and metabolic syndrome were recorded and analysed. Liver biopsies were scored for the degree of steatosis, necroinflammation and fibrosis. Correlation coefficients were calculated to assess the association between changes in histological scores and metabolic parameters.
  
  
  RESULTS
  Seventeen patients who had been followed up for a median period of 6.1 (range: 3.8-8.0) years underwent a second liver biopsy. Nine (53%) patients had progressive disease with worsening of fibrosis score. No statistically significant correlation was found between the changes in histological scores and metabolic parameters. Seven patients developed hypertension or diabetes mellitus during the period of follow-up.
  
  
  CONCLUSIONS
  Non-alcoholic fatty liver disease is a progressive disease in Chinese patients as in their Caucasian counterparts. Diagnosis of non-alcoholic fatty liver disease may predate development of new components of metabolic syndrome.
authors.affiliation: Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.
authors.forename: A Y
authors.initials: AY
authors.lastname: Hui
authors.forename: V W-S
authors.initials: VW
authors.lastname: Wong
authors.forename: H L-Y
authors.initials: HL
authors.lastname: Chan
authors.forename: C-T
authors.initials: CT
authors.lastname: Liew
authors.forename: J L-Y
authors.initials: JL
authors.lastname: Chan
authors.forename: F K-L
authors.initials: FK
authors.lastname: Chan
authors.forename: J J-Y
authors.initials: JJ
authors.lastname: Sung
mesh_terms: D000328:Adult; D044466:Asian People; D001706:Biopsy; D018450:Disease Progression; D005234:Fatty Liver / Q000097:blood / Q000208:ethnology* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006723:Hong Kong; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000208:ethnology; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index