title: Synthesis and establishment of stereochemistry of the unusual polyoxazole-thiazole based cyclopeptide YM-216391 isolated from Streptomyces nobilis.
abstract: A concise total synthesis of the unusual oxazole-based cyclopeptide structure YM-216391, which also establishes the stereochemistry of the natural product i.e. 1, is described.
authors.affiliation: School of Chemistry, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
authors.forename: Jon
authors.initials: J
authors.lastname: Deeley
authors.forename: Gerald
authors.initials: G
authors.lastname: Pattenden
mesh_terms: D008968:Molecular Conformation; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000302:isolation & purification; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D013302:Streptomyces / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D010080:Oxazoles; D010456:Peptides, Cyclic; C499972:YM 216391