title: Radical trifluoromethylation of titanium ate enolate.
abstract: The radical trifluoromethylation of ketone titanium ate enolates gave alpha-CF3 ketones in good yields. The use of excess amount of LDA and Ti(OiPr)4 in the preparation of titanium ate enolates is the key to the efficient radical trifluoromethylation. [reaction: see text]
authors.affiliation: Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan.
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Itoh
authors.forename: Koichi
authors.initials: K
authors.lastname: Mikami
mesh_terms: D004952:Esters; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D014025:Titanium
chemical_list: D004952:Esters; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D009942:Organometallic Compounds; C511647:titanium ate enolate; C013314:trifluoromethyl hypofluorite; D014025:Titanium