title: Effects of age and sex on hematologic and serum biochemical values of vervet monkeys (Chlorocebus aethiops sabaeus).
abstract: Hematologic and serum biochemical values are of great importance in assessing animal health. Normal reference ranges for vervet monkeys (Chlorocebus aethiops sabaeus) have seldom been reported, making it difficult for clinicians to interpret blood values. The purpose of this study was to determine what effects age and sex have on hematologic and serum biochemical values of vervet monkeys and to establish clinically relevant reference ranges for all life stages of each gender. Blood samples were collected from 140 healthy vervet monkeys of Caribbean origin consisting of 60 females and 80 males. Male and female data were displayed separately within six life-stage categories (yearlings, juveniles, adolescents, young adults, adults, and aged). The effects of sex and age on these values were examined statistically. Significant age-related factors included red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, alkaline phosphatase, albumin, total protein, globulin, direct bilirubin, blood urea nitrogen, creatinine, glucose, calcium, phosphorus, potassium, albumin/globulin ratio, blood urea nitrogen/creatinine ratio, and sodium/potassium ratio values. Significant sex-related values included red blood cell count, hemoglobin, hematocrit, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, neutrophil count, total bilirubin, direct bilirubin, creatinine, glucose, calcium, phosphorus, total carbon dioxide, chloride, potassium, and sodium/potassium ratio values.
authors.affiliation: Division of Laboratory Animal Medicine, David Geffen School of Medicine, UCLA, Box 951718, Los Angeles, California 90095-17181, USA.
authors.forename: Akiko
authors.initials: A
authors.lastname: Sato
authors.forename: Lynn A
authors.initials: LA
authors.lastname: Fairbanks
authors.forename: Timothy
authors.initials: T
authors.lastname: Lawson
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Lawson
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary*; D002522:Chlorocebus aethiops / Q000097:blood*; D005260:Female; D006403:Hematologic Tests / Q000662:veterinary*; D007756:Laboratory Animal Science / Q000379:methods*; D008297:Male; D012737:Sex Factors