title: Artificial diiron proteins: from structure to function.
abstract: De novo protein design provides an attractive approach for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. In this article, we summarize the design, structure determination, and functional properties of a family of artificial diiron proteins.
authors.affiliation: Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Calhoun
authors.forename: Flavia
authors.initials: F
authors.lastname: Nastri
authors.forename: Ornella
authors.initials: O
authors.lastname: Maglio
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Pavone
authors.forename: Angela
authors.initials: A
authors.lastname: Lombardi
authors.forename: William F
authors.initials: WF
authors.lastname: DeGrado
mesh_terms: D000595:Amino Acid Sequence; D020134:Catalytic Domain; D019281:Dimerization; D007501:Iron / Q000737:chemistry; D008667:Metalloproteins / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D020836:Protein Structure, Quaternary; D055672:Static Electricity; D013816:Thermodynamics
chemical_list: D008667:Metalloproteins; D007501:Iron