title: Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits.
abstract: Metabotropic GABAB receptors predominantly function as heterodimers of GABAB(1) and GABAB(2) subunits, but GABAB(1) can also form functional receptors in the absence of GABAB(2). Mice lacking the GABAB(1) subunit have altered behavioural responses in tests for anxiety and depression. In these studies, we investigated anxiety and depression in GABAB(2)-deficient mice. We compared the effects directly with that of genetic deletion of the GABAB(1) receptor subunit. Both GABAB(1) and GABAB(2)-deficient mice were found to be more anxious than wild type in the light-dark box paradigm. In contrast, these mice exhibited an antidepressant-like behaviour in the forced swim test. Taken together, these data suggest that heterodimeric GABAB(1,2) receptors are required for the normal regulation of emotional behaviour.
authors.affiliation: Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.
authors.forename: Cedric
authors.initials: C
authors.lastname: Mombereau
authors.forename: Klemens
authors.initials: K
authors.lastname: Kaupmann
authors.forename: Martin
authors.initials: M
authors.lastname: Gassmann
authors.forename: Bernhard
authors.initials: B
authors.lastname: Bettler
authors.forename: Herman
authors.initials: H
authors.lastname: van der Putten
authors.forename: John F
authors.initials: JF
authors.lastname: Cryan
mesh_terms: D000818:Animals; D001007:Anxiety / Q000235:genetics*; D001522:Behavior, Animal / Q000502:physiology; D003863:Depression / Q000235:genetics*; D005106:Exploratory Behavior / Q000502:physiology; D007103:Immobilization / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000235:genetics; D021122:Protein Subunits / Q000172:deficiency / Q000235:genetics; D011930:Reaction Time / Q000502:physiology; D018080:Receptors, GABA-B / Q000172:deficiency* / Q000235:genetics*; D013550:Swimming
chemical_list: D021122:Protein Subunits; D018080:Receptors, GABA-B