[Ecogenetic aspects of acute side effects caused by angiotensin converting enzyme inhibitors].
Angiotensin converting enzyme inhibitors are currently used in the treatment of different cardiovascular diseases. Acute side effects of acei have been attributed to bradykinin. We have evidenced a decrease catabolism of des-arg9-bradykinin in the plasma of patients who presented such side effects. This anomaly is associated with a decreased activity of plasma aminopeptidase p which is, at least partially, of genetic origin.
Adam
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Université de Montreal, Québec, Canada.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D002877:Chromosomes, Human / Q000187:drug effects; D006801:Humans; D007705:Kinins / Q000187:drug effects / Q000378:metabolism
D000806:Angiotensin-Converting Enzyme Inhibitors; D007705:Kinins