title: Application of Mosher's method for absolute configuration assignment and resolution of 2-hydroxypyrrolizidinones.
abstract: Derivatization of racemic 2-hydroxypyrrolizidinones with S-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (MTPA-Cl) was successfully used for enantiomer separation and absolute configuration assignment.
authors.affiliation: Dipartimento di Chimica Organica U. Schiff, Università degli Studi di Firenze, Italy. franca.cordero@unifi.it
authors.forename: Franca M
authors.initials: FM
authors.lastname: Cordero
authors.forename: Federica
authors.initials: F
authors.lastname: Pisaneschi
authors.forename: Maria
authors.initials: M
authors.lastname: Salvati
authors.forename: Silvia
authors.initials: S
authors.lastname: Valenza
authors.forename: Cristina
authors.initials: C
authors.lastname: Faggi
authors.forename: Alberto
authors.initials: A
authors.lastname: Brandi
mesh_terms: D003461:Crystallography; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010648:Phenylacetates / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010648:Phenylacetates; D011760:Pyrrolidinones; C101363:alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride