Comparison of fine-scale recombination rates in humans and chimpanzees.
We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite approximately 99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.
Winckler
Wendy
W
Department of Molecular Biology and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114-2622, USA.
Myers
Simon R
SR
Richter
Daniel J
DJ
Onofrio
Robert C
RC
McDonald
Gavin J
GJ
Bontrop
Ronald E
RE
McVean
Gilean A T
GA
Gabriel
Stacey B
SB
Reich
David
D
Donnelly
Peter
P
Altshuler
David
D
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000235:genetics; D033481:Chromosomes, Mammalian / Q000235:genetics; D019143:Evolution, Molecular; D016678:Genome; D015894:Genome, Human; D005838:Genotype; D005914:Globins / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008390:Markov Chains; D009010:Monte Carlo Method; D002679:Pan troglodytes / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid
D006680:HLA Antigens; D005914:Globins