Description of a technique for anaesthetizing pregnant ewes for fetal surgery.
General anaesthesia in 12 pregnant ewes undergoing surgery for fetal physiological research was supplemented with an intravenous infusion of remifentanil. This allowed us to employ a lighter plane of surgical anaesthesia and to use intermittent positive pressure ventilation. Our aim was to improve fetomaternal outcome. We monitored maternal pulse, blood pressure, transcutaneous oxygen saturation and end-tidal carbon dioxide levels. Remifentanil doses of 0.75-2.0 microg/kg/min were needed and typically this allowed halothane concentrations of 1-1.5% to be used for maintenance of anaesthesia. Surgery lasted up to 2.5 h. All 12 ewes and their singleton fetuses survived the peri- and postoperative period in good condition.
Webster
V L
VL
University Department of Anaesthesia, Queen's Medical Centre, University Hospital, Nottingham, UK.
Cara
D M
DM
Walker
R M
RM
Ramsay
M M
MM
Aitkenhead
A R
AR
D000773:Anesthesia, Obstetrical / Q000379:methods / Q000662:veterinary*; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000818:Animals; D001785:Blood Gas Monitoring, Transcutaneous / Q000662:veterinary; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000032:analysis; D005260:Female; D005333:Fetus / Q000601:surgery*; D006221:Halothane / Q000008:administration & dosage; D010100:Oxygen / Q000097:blood; D010880:Piperidines / Q000008:administration & dosage; D011247:Pregnancy; D011674:Pulse; D000077208:Remifentanil; D012756:Sheep / Q000196:embryology*
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D010880:Piperidines; D002245:Carbon Dioxide; D000077208:Remifentanil; D010100:Oxygen; D006221:Halothane