[The index F and relative index Fr of chromatographic fingerprints].
OBJECTIVE
The index F and relative index Fr of chromatographic fingerprints were firstly proposed to indicate how bountiful was the information in traditional Chinese medicines chromatographic fingerprints, how better was the separation effect, how high was the peak signal and how equal were the peak areas.


METHODS
The index F and relative index Fr of chromatographic fingerprints were firstly applied to evaluate the chromatographic fingerprints results of traditional Chinese medicines determined by the reversed-phase high performance liquid chromatographic method and high performance capillary electrophoresis.


RESULTS
The Shegan Kangbingdu injection and all its traditional Chinese medicines ingredients had been evaluated by F and Fr, so did for the HPLC fingerprints of Radix salviae miltiorrhizae reported in literature. As the same time, the F and Fr of the capillary electrophoresis fingerprints of Folium isatidis, Rhizoma belamcandae and compound liquorice tablets were successfully determined. As far as F was concerned, there was no evident difference between HPLC and capillary electrophoresis (CE), but the Fr values came from CE was usually a thousand times more than that from HPLC.


CONCLUSIONS
The F and Fr can be applied to evaluate objectively, simply and thoroughly the chromatographic fingerprints.
Sun
Guo-Xiang
GX
College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. gxswmwys@163.com
Liu
Xiao-Ling
XL
Deng
Xiang-Yu
XY
Sun
Yu-Qing
YQ
Bi
Kai-Shun
KS
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D019075:Electrophoresis, Capillary / Q000379:methods*; D007267:Injections; D027621:Iridaceae / Q000737:chemistry; D031239:Lonicera / Q000737:chemistry; D010936:Plant Extracts; D010946:Plants, Medicinal / Q000737:chemistry*; D027561:Salvia miltiorrhiza
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts