title: Asymmetric cyclopropane synthesis via phosphine oxide mediated cascade reactions.
abstract: A silyloxy-THF has been converted into a cyclopropane containing three stereocentres as mixture of diastereoisomers. The mechanism of the reaction has been established and the source of stereochemical leakage proposed. An alternative stereospecific cascade reaction has been discovered.
authors.affiliation: University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Boesen
authors.forename: David J
authors.initials: DJ
authors.lastname: Fox
authors.forename: Warren
authors.initials: W
authors.lastname: Galloway
authors.forename: Daniel Sejer
authors.initials: DS
authors.lastname: Pedersen
authors.forename: Charles R
authors.initials: CR
authors.lastname: Tyzack
authors.forename: Stuart
authors.initials: S
authors.lastname: Warren
mesh_terms: D003521:Cyclopropanes / Q000138:chemical synthesis*; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D012821:Silanes / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003521:Cyclopropanes; D005663:Furans; D010720:Phosphines; D012821:Silanes