title: Effect of statin therapy on risk of ventricular arrhythmia among patients with coronary artery disease and an implantable cardioverter-defibrillator.
abstract: Hydroxymethylglutaryl coenzyme-A reductase inhibitors, or statins, have been shown to decrease mortality rates in patients who have coronary artery disease. It has been postulated that part of the mortality benefit conferred by statins is due to a decrease in ventricular arrhythmias. We assessed the effect of statin therapy on recurrent ventricular arrhythmias in 281 patients who developed coronary artery disease after implantable cardioverter-defibrillator placement. Statin therapy was associated with a significant decrease in the risk of ventricular arrhythmia that would require implantable cardioverter-defibrillator therapy.
authors.affiliation: Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: John H
authors.initials: JH
authors.lastname: Chiu
authors.forename: Raed H
authors.initials: RH
authors.lastname: Abdelhadi
authors.forename: Mina K
authors.initials: MK
authors.lastname: Chung
authors.forename: Hitinder S
authors.initials: HS
authors.lastname: Gurm
authors.forename: Nassir F
authors.initials: NF
authors.lastname: Marrouche
authors.forename: Walid I
authors.initials: WI
authors.lastname: Saliba
authors.forename: Andrea
authors.initials: A
authors.lastname: Natale
authors.forename: David O
authors.initials: DO
authors.lastname: Martin
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000628:therapy*; D017147:Defibrillators, Implantable; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D055502:Secondary Prevention; D014693:Ventricular Fibrillation / Q000628:therapy*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors