Synthesis of 4-hydroxy-1-methylindole and benzo[b]thiophen-4-ol based unnatural flavonoids as new class of antimicrobial agents.
Synthesis of nitrogen and sulfur heterocyclic mimics of furanoflavonoids have been achieved for the first time. Synthesized flavonoid alkaloids and thiophenyl flavonoids have been screened for antifungal and antibacterial activities. All the test compounds barring 25 exhibited antifungal activity. The compound 19 was the best and showed comparable MICs to the known compound karanjin. Compounds 5, 12, 14 and 22 also showed comparable MIC to karanjin.
Yadav
Prem P
PP
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
Gupta
Prasoon
P
Chaturvedi
A K
AK
Shukla
P K
PK
Maurya
Rakesh
R
D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology*
C502255:4-hydroxy-1-methylindole; D005419:Flavonoids; D007211:Indoles; D013876:Thiophenes; C502254:benzo(b)thiophen-4-ol