title: [Amniotic-membrane and limbic stem-cell transplantation in the management of ocular burns].
abstract: Severe ocular burns are potentially blinding injuries. During the first month, ocular surface destruction is caused by a vicious circle of complications that may result in the pathological state of total limbal stem-cell deficiency. Amniotic membrane transplantation can be considered an early, if not immediate, surgical procedure to promote epithelialization and calm inflammation so that scarring-induced sequelae can be prevented in the chronic stage. However, when partial or total limbal stem-cell deficiency involves one or both eyes, corneal surface reconstruction relies on transplantation of autologous limbal stem cells, an allogenic source of limbal stem cells or corneal epithelial stem-cell transplantation. In this late stage, amniotic-membrane transplantation may improve prognosis of keratolimbal allograft and is useful in the treatment of symblepharons.
authors.affiliation: Service d'Ophtalmologie, CHU de Rouen, Hôpital Charles Nicolle, boulevard Gambetta, 76031 Rouen cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Muraine
mesh_terms: D001684:Biological Dressings; D016039:Corneal Transplantation; D005126:Eye Burns / Q000628:therapy*; D006801:Humans; D016850:Limbus Corneae / Q000166:cytology; D033581:Stem Cell Transplantation / Q000379:methods