Pregnancy outcomes with increased clomiphene citrate dose.
Our objective was to evaluate whether ovulation induction with an increased clomiphene citrate dose of 150-250 mg/day for 5 days adversely affected pregnancy outcome. A retrospective chart review of 1910 medical records yielded 119 pregnancies with sufficient information regarding domiphene dose and pregnancy outcome. Of the 84 pregnancies that followed clomiphene doses of 50-100 mg/day, 32.1% ended in spontaneous abortion, 10.7% in ectopic gestation, 1.2% with congenital malformations, 2.4% in stillbirth and 53.6% in normal gestation. Of the 35 pregnancies that followed clomiphene doses of 150-250 mg/day, 34.3% ended in spontaneous abortion, 5.7% in ectopic gestation, 2.9% with congenital malformations, 2.9% in stillbirth and 54.3% in normal gestation. These differences were not statistically significant. These data suggest that a clomiphene dose of 150-250 mg/day does not appear to increase adverse pregnancy outcomes.
Jain
J K
JK
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Women's and Children's Hospital, Los Angeles, CA 90033, USA.
Kuo
J
J
D000022:Abortion, Spontaneous / Q000453:epidemiology; D002996:Clomiphene / Q000008:administration & dosage*; D000013:Congenital Abnormalities / Q000453:epidemiology; D005260:Female; D006801:Humans; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011271:Pregnancy, Ectopic / Q000453:epidemiology
D002996:Clomiphene