title: [Bilateral frontal polymicrogyria and Ehlers-Danlos syndrome].
abstract: The authors describe the case of a six-year-old girl with Ehlers-Danlos syndrome associated to bilateral symmetrical frontal polymicrogyria. Several extracellular matrix components, including collagen, are directly implicated in the neuronal migration. We think that a defect in collagen or in another extracellular matrix protein during fetal development could result in this association.
authors.affiliation: Service de pédiatrie A, hôpital Manchester, 45 avenue Manchester, 08011 Charleville-Mézières cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Ezzeddine
authors.forename: P
authors.initials: P
authors.lastname: Sabouraud
authors.forename: C
authors.initials: C
authors.lastname: Eschard
authors.forename: O
authors.initials: O
authors.lastname: El Tourjuman
authors.forename: N
authors.initials: N
authors.lastname: Bednarek
authors.forename: J
authors.initials: J
authors.lastname: Motte
mesh_terms: D002648:Child; D003094:Collagen / Q000378:metabolism; D004535:Ehlers-Danlos Syndrome / Q000150:complications*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D017628:Microglia / Q000473:pathology*
chemical_list: D003094:Collagen