[New methyl-quinoxaline derivatives with antimicrobial activity].
This paper presents the synthesis of six new quinoxaline derivatives cycloadditions products of N-monoxide and N,N'-dioxide of 6-methyl-quinoxaline. The chemical structure of new azabicyclic products was confirmed by C, H, N elemental analysis and spectral analysis (IR and RMN). We have tested the antimicrobial activity of the new synthesized azabicyclic derivatives by the diffusimetric method. The assay was made on the seven microorganisms, gram-positive and gram-negative bacteria. The results show that the new compounds are more active against the gram-positive bacteria and Candida albicans.
Ungureanu
Margareta
M
Université de Médicine et Pharmacie Gr.T. Popa Iaşi, Faculté de Bioinginerie Médicale.
Poiată
Antonia
A
Tuchiluş
Cristina
C
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D011810:Quinoxalines