Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages.
OBJECTIVE
To determine the aneuploidy rate in embryos of women with idiopathic recurrent miscarriages and to evaluate whether preimplantation genetic diagnosis for aneuploidy screening could be a feasible approach to improve the possibility of successful pregnancy in these couples.


METHODS
Prospective cohort study.


METHODS
Tertiary university referral center.


METHODS
Women (n = 49) with recurrent idiopathic miscarriages.


METHODS
In vitro fertilization with preimplantation genetic diagnosis for aneuploidy screening.


METHODS
Ongoing pregnancy rate (PR) and aneuploidy rate.


RESULTS
The aneuploidy rate was, respectively, 43.85% and 66.95% in the younger and older group. The ongoing PR per cycle was 25.71% in the younger and 2.94% in the older patients.


CONCLUSIONS
There is no therapeutic evidence to prescribe IVF with or without preimplantation genetic diagnosis for aneuploidy screening for this heterogeneous group of patients.
Platteau
Peter
P
Center for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel), Brussels, Belgium. peter.platteau@az.vub.ac.be
Staessen
Catherine
C
Michiels
An
A
Van Steirteghem
Andre
A
Liebaers
Inge
I
Devroey
Paul
P
D000026:Abortion, Habitual / Q000175:diagnosis* / Q000235:genetics*; D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations; D005260:Female; D005820:Genetic Testing; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011247:Pregnancy; D011256:Pregnancy Outcome; D019836:Preimplantation Diagnosis; D011446:Prospective Studies