[Experimental study on protecting intestinal barrier function of Huoxiang Zhengqi soft capsule].
OBJECTIVE
To study the effect of Huoxiang Zhengqi soft capsule on protecting intestinal barrier.


METHODS
Lower limb ischemic reperfusion model was induced in Wistar rats. The Chinese medicine groups were administered orally with Huoxiang Zhengqi soft capsule before inoculation respectively. The small intestinal histopathology and ultrastructural of rats were observed with optical microscope and electronic microscope respectively. Mucus was observed under AB-PAS staining, mast cells were studied under toluidine blue staining, and serum NO was determined.


RESULTS
After Lower limb ischemic reperfusion, the intestinal barrier function was severely damaged. Huoxiang Zhengqi soft capsule could significantly reduce the levels of the serum NO (P < 0.01).


CONCLUSIONS
Huoxiang Zhengqi soft capsule has apparent protective effect on the intestinal barrier function in lower limb ischemic reperfusion rats.
Xie
Yi-chong
YC
General Hospital of Tianjin Medical University, Tianjin 300052, China.
Tang
Fang
F
D000818:Animals; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006614:Hindlimb / Q000098:blood supply*; D007082:Ileum / Q000473:pathology*; D007413:Intestinal Mucosa / Q000473:pathology / Q000648:ultrastructure; D007511:Ischemia / Q000150:complications; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D009093:Mucus / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology*
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D020011:Protective Agents