Beneficial effects of a polar fraction of garlic (Allium sativum Linn) oil in rats fed with two different high fat diets.
Feeding a diet containing 20% of sesame oil (SO) or coconut oil (CNO) along with 2% cholesterol to rats for two months showed differences in their serum and tissue lipid profile and certain enzyme activities. Hyperlipidemia and related oxidative effects were more pronounced in coconut oil fed rats than those fed sesame oil. Feeding a combination of the oils (10% CNO +10% SO) lowered significantly the hyperlipidemia and certain other deleterious effects of CNO. Feeding a polar fraction of garlic oil (PFGO) prepared in the same way as for ajoene and administered at a dosage of 100 mg/kg along with each of the above oil containing diets counteracted significantly the hyperlipidemic, oxidant and also most of the other deleterious effects of the oils like raised lipid levels in serum and tissues, raised serum levels of AST and tissue levels of HMGCoA reductase and the lowered serum and tissue levels of glutathione reductase. The results support the claims that ajoene, the major polar compound of garlic oil, has very good biological action, which warrants further study.
Augusti
K T
KT
Department of Medical Biochemistry, School of Medical Education, (M G University Center) Kottayam, India. ktaugusti@yahoo.co.uk
Chackery
Julie
J
Jacob
Julie
J
Kuriakose
Sinu
S
George
Sharlet
S
Nair
Sunitha S
SS
D000498:Allyl Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000074263:Coconut Oil; D004041:Dietary Fats / Q000008:administration & dosage*; D005980:Glutathione Reductase / Q000378:metabolism; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D006949:Hyperlipidemias / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D012715:Sesame Oil / Q000008:administration & dosage; D013440:Sulfides / Q000008:administration & dosage / Q000627:therapeutic use*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014166:Transferases / Q000378:metabolism
D000498:Allyl Compounds; D004041:Dietary Fats; D010938:Plant Oils; D013440:Sulfides; D017392:Thiobarbituric Acid Reactive Substances; C038491:allyl sulfide; D012715:Sesame Oil; D006903:Hydroxymethylglutaryl CoA Reductases; D005980:Glutathione Reductase; D014166:Transferases; D000074263:Coconut Oil