Novel jadomycins: incorporation of non-natural and natural amino acids.
Electrospray ionization mass spectrometry of extracts from Streptomyces venezuelae ISP5230 cultures grown on chemically synthesized non-natural L-amino acids, D-amino acids or any of the 20 natural amino acids demonstrated incorporation of the amino acid into a jadomycin B analogue.
Jakeman
David L
DL
College of Pharmacy, Dalhousie University, 5968 College street, Halifax, Nova Scotia, B3H 3J5, Canada. david.jakeman@dal.ca
Farrell
Spring
S
Young
Wendy
W
Doucet
René J
RJ
Timmons
Shannon C
SC
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D008968:Molecular Conformation; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D013302:Streptomyces / Q000737:chemistry*
D000596:Amino Acids; D007546:Isoquinolines; C081750:jadomycin B