Molecular mechanisms of endochondral bone development.
Endochondral bone development is a complex process in which undifferentiated mesenchymal cells differentiate into chondrocytes, which then undergo well-ordered and controlled phases of proliferation, hypertrophic differentiation, death, blood vessel invasion, and finally replacement of cartilage with bone. The process recapitulates basic and fundamental mechanisms of cell biology with a highly specific spatial and temporal pattern, and it thus constitutes an excellent model for the analysis of such mechanisms. In recent years, the tools provided by modern genetic both in mice and men have been instrumental in the process of identifying and dissecting basic molecular mechanisms of endochondral bone formation. This review is a brief summary of the current knowledge about some of the crucial factors involved in growth plate development.
Provot
Sylvain
S
Endocrine Unit, MGH-Harvard Medical School, Boston, MA 02114, USA.
Schipani
Ernestina
E
D000818:Animals; D001846:Bone Development / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D001842:Bone and Bones / Q000196:embryology* / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology*; D020219:Chondrogenesis / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D053823:Hedgehog Proteins; D006801:Humans; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism; D010011:Osteocytes / Q000166:cytology / Q000502:physiology*; D044162:Parathyroid Hormone-Related Protein / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; D009363:Neoplasm Proteins; D044162:Parathyroid Hormone-Related Protein; D015534:Trans-Activators; D014157:Transcription Factors