title: Management of malignant pericardial effusion with instillation of mitomycin C in non-small cell lung cancer.
abstract: BACKGROUND
  To evaluate the clinical efficacy and safety of mitomycin C in the local control of malignant pericardial effusion, we carried out a trial of pericardial drainage with local instillation of mitomycin C in eight patients who suffered from cardiac tamponade or symptomatic large pericardial effusion caused by advanced non-small cell lung cancer.
  
  
  METHODS
  After complete removal of the pericardial effusion by an ultrasound-guided inserted catheter, 2 mg of mitomycin C was instilled into the pericardial space via the catheter.
  
  
  RESULTS
  The drainage catheter was successfully removed in all patients. The duration of pericardial drainage ranged from 7 to 14 days (median 10.5 days). Six of the eight patients achieved a complete remission of pericardial effusions without any adverse effects.
  
  
  CONCLUSIONS
  Intrapericardial instillation of 2 mg of mitomycin C was feasible and demonstrated a promising response against malignant pericardial effusion resulting from non-small cell lung cancer.
authors.affiliation: Maebashi Red Cross Hospital, Department of Respiratory Medicine, 3-21-36, Asahi-cho, Maebashi, Gunma 377-0014, Japan. k-kaira@maebashi.jrc.or.jp
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Kaira
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takise
authors.forename: Go
authors.initials: G
authors.lastname: Kobayashi
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Utsugi
authors.forename: Takeo
authors.initials: T
authors.lastname: Horie
authors.forename: Takanori
authors.initials: T
authors.lastname: Mori
authors.forename: Hisao
authors.initials: H
authors.lastname: Imai
authors.forename: Masahito
authors.initials: M
authors.lastname: Inazawa
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications*; D002305:Cardiac Tamponade / Q000209:etiology; D004322:Drainage; D005260:Female; D006801:Humans; D007322:Instillation, Drug; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D010490:Pericardial Effusion / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin