title: Evaluation of a microcatheter-arterial port system for intraarterial therapy in an animal model.
abstract: A new microcatheter-arterial port system for transarterial regional therapy was evaluated in a swine model. Subclavian or femoral access was followed by superselective catheterization of target arteries (hepatic, n = 6; splenic, n = 3). A hemostatic sleeve was placed at the arterial puncture site. Implantation into the target vessel succeeded in all nine placements (100%). After animal movement, no microcatheter tip moved by more than 10 mm. A small hematoma developed at one of the subclavian insertion sites. This system holds promise for transarterial therapies for regional cancer therapy.
authors.affiliation: Division of Interventional Radiology, Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Maxim
authors.initials: M
authors.lastname: Itkin
authors.forename: Je H
authors.initials: JH
authors.lastname: Won
authors.forename: Timothy W I
authors.initials: TW
authors.lastname: Clark
mesh_terms: D000818:Animals; D002408:Catheters, Indwelling; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000295:instrumentation; D004867:Equipment Design; D005263:Femoral Artery; D005471:Fluoroscopy; D006489:Hemostatic Techniques / Q000295:instrumentation; D006499:Hepatic Artery; D007261:Infusions, Intra-Arterial / Q000295:instrumentation; D008904:Miniaturization; D023421:Models, Animal; D015641:Radiography, Interventional; D013157:Splenic Artery; D013348:Subclavian Artery; D013552:Swine