[Determination of fenfluramine, diethylpropion and mazindol in slimming foods by gas chromatography-mass spectrometry].
A gas chromatography-mass spectrometry (GC/MS) analytical method for three anorectics drugs, fenfluramine, diethylpropion and mazindol, illegally adulterated in slimming foods has been developed. They can be simultaneously identified and quantified. The samples were extracted with chloroform, and then separated by GC with an HP-5MS GC capillary column. The temperature programming was started at 70 degrees C. The temperature was held at this temperature for 2 min and then increased at 10 degrees C/min to 280 degrees C. The completely separated peaks were identified by MS with a quadrupole mass filter and quantitated in selected ion monitoring mode. Compared with the NIST98 library, the matching qualities of the drugs in foods were all over 90%. The calibration curves of the drugs were excellent with correlation coefficients between 0.9991 and 0.9999, and relative standard deviations between 1.6% and 2.2%. The recoveries were between 96.0% and 102.4%. The results demonstrated that this method is suitable for the identification and quantitation of these anorectics drugs in slimming foods.
Feng
Jiali
J
Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China. garlly@163.net
Pan
Zhenqiu
Z
Cao
Huajuan
H
Wang
Chun'e
C
D001067:Appetite Depressants / Q000032:analysis* / Q000737:chemistry; D002725:Chloroform / Q000737:chemistry; D004038:Diet, Reducing; D004053:Diethylpropion / Q000032:analysis* / Q000737:chemistry; D005277:Fenfluramine / Q000032:analysis* / Q000737:chemistry; D005502:Food; D005504:Food Analysis / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008454:Mazindol / Q000032:analysis* / Q000737:chemistry; D052616:Solid Phase Extraction / Q000379:methods
D001067:Appetite Depressants; D005277:Fenfluramine; D002725:Chloroform; D008454:Mazindol; D004053:Diethylpropion