In vitro bioassay as a predictor of in vivo response.
BACKGROUND
There is a substantial discrepancy between in vitro and in vivo experiments. The purpose of the present work was development of a theoretical framework to enable improved prediction of in vivo response from in vitro bioassay results.


RESULTS
For dose-response curve reaches a plateau in vitro we demonstrated that the in vivo response has only one maximum. For biphasic patterns of biological response in vitro both the bimodal and biphasic in vivo responses might be observed.


CONCLUSIONS
As the main result of this work we have demonstrated that in vivo responses might be predicted from dose-effect curves measured in vitro.
Barnard
Ross
R
Department of Biochemistry, The University of Queensland, Brisbane, Qld 4072, Australia. barnard@biosci.uq.edu.au
Gurevich
Konstantin G
KG
D001681:Biological Assay / Q000379:methods*; D004305:Dose-Response Relationship, Drug