Novel mutual pro-drugs of 2',3'-dideoxyinosine with 3-octadecyloxy-propane-1,2-diol by straightforward enzymatic regioselective synthesis in acetone.
Novel mutual pro-drugs in which 2',3'-dideoxyinosine anti-HIV (human immunodeficiency virus) drug and 3-octadecyloxy-propane-1,2-diol anti-inflammatory drug were attached to the same molecule via different biodegradable linkages, were synthesized through two-step enzymatic transesterification by a commercial lipase in acetone.
Sun
Xiao-Feng
XF
Department of Chemistry, Zhejiang University, Hangzhou, 310027, P.R. China.
Wu
Qi
Q
Wang
Na
N
Cai
Ying
Y
Lin
Xian-Fu
XF
D000096:Acetone; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry; D001671:Biochemistry / Q000379:methods*; D016049:Didanosine / Q000138:chemical synthesis* / Q000737:chemistry; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D004951:Esterification; D005995:Glyceryl Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D008049:Lipase / Q000737:chemistry / Q000378:metabolism; D011355:Prodrugs / Q000138:chemical synthesis*
D019380:Anti-HIV Agents; D000893:Anti-Inflammatory Agents; D004800:Enzymes, Immobilized; D005995:Glyceryl Ethers; D011355:Prodrugs; D000096:Acetone; C033433:batyl alcohol; D008049:Lipase; D016049:Didanosine