Whole blood and red blood cell manganese reflected signal intensities of T1-weighted magnetic resonance images better than plasma manganese in liver cirrhotics.
We examined whole blood (MnB), red blood cell (MnRBC), plasma (MnP) and urinary Mn (MnU) concentrations in 22 liver cirrhotics and 10 healthy controls to evaluate Mn concentration in which a fraction of biological samples best reflects pallidal signal intensities (pallidal index; PI) on T1-weighted magnetic resonance images (MRI) in liver cirrhotics. Increased signal intensity in the globus pallidus was observed in 18 (81.8%) of the 22 patients with liver cirrhosis. In a transplanted patient, increased pallidal signals also resolved as his liver function tests normalized after liver transplantation. There were significant correlations between MnB/MnRBC and PI (rho=0.529, rho=0.573, respectively) in liver cirrhotics, although no significant correlation was observed between MnP/MnU and PI. According to a multiple linear regression, MnB and MnRBC reflected the signal intensities of T1-weighted MRI better than MnP or MnU.
Choi
Younghee
Y
Department of Occupational and Environmental Medicine, Ulsan University Hospital, South Korea.
Park
Ji Kang
JK
Park
Neung Hwa
NH
Shin
Jung Woo
JW
Yoo
Cheol-In
CI
Lee
Choong Ryeol
CR
Lee
Hun
H
Kim
Hyo Kyung
HK
Kim
Sung-Ryul
SR
Jung
Tae-Hum
TH
Park
Jungsun
J
Yoon
Chung Sik
CS
Kim
Yangho
Y
D000328:Adult; D016022:Case-Control Studies; D004912:Erythrocytes / Q000737:chemistry*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008345:Manganese / Q000097:blood*; D008875:Middle Aged
D008345:Manganese