Phenotype-first screening for the identification of novel drug targets.
Modern drug discovery is predominantly a target-driven process, where success is intricately linked to the selection of an appropriate molecular target. Ideally, there is conclusive functional evidence that a selected target is disease-relevant and, furthermore, suitable for drug development. Phenotype-first screening is a highly attractive approach for target identification because it offers the unique possibility to analyse entire genomes in an unbiased fashion for disease-related phenotypes. Various studies have demonstrated that phenotype-first screening can be successfully applied to the identification of drug targets, thus establishing this approach as a valuable tool for future target discovery efforts.
Austen
Matthias
M
DeveloGen AG, Rudolf-Wissell-Strasse 28, 37079 Göttingen, Germany.
Dohrmann
Cord
C
D000818:Animals; D015195:Drug Design; D020869:Gene Expression Profiling; D016678:Genome; D023281:Genomics / Q000379:methods; D006801:Humans; D023421:Models, Animal; D009154:Mutation; D010641:Phenotype