Mouse models of human neurodegenerative disorders: requirements for medication development.
Central nervous system diseases constitute a major target for drug development. Transgenic mouse models, in which genes identified in familial forms of human brain diseases are expressed in mouse neurons and glia, offer opportunities to detect and follow pathologic progression and provide potential biomarkers by which to assess therapeutic interventions. Evidence for Alzheimer disease suggests some starting requirements for the experimental data that could enhance the likelihood of developing medications in these mouse models that would also be effective in humans.
Bloom
Floyd E
FE
Neurome Inc, La Jolla, CA 92037, USA. fbloom@neurome.com
Reilly
John F
JF
Redwine
Jeff M
JM
Wu
Chi-Cheng
CC
Young
Warren G
WG
Morrison
John H
JH
D000544:Alzheimer Disease / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D015415:Biomarkers; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000628:therapy
D016564:Amyloid beta-Protein Precursor; D015415:Biomarkers