title: [The effect of ultra high molecular weight polyethylene particle on the tissues of joint prosthesis].
abstract: OBJECTIVE
  To study the effect of the high molecular weight polyethylene on the periprosthetic tissue in vivo as to give some reference to treatment of loosening hip arthroplasty.
  
  
  METHODS
  Every lower limb of 20 New Zealand white rabbits was implanted a Co-Cr-Mo plug in femur by intercondylar notch. 15 mg polyethylene particles, dispersed in 1.5 ml normal saline solution, were injected into one knee joint. The other knee joint was injected 1.5 ml normal saline solution as control. This procedure was repeated 2,4,6,8 and 10 weeks after the implantation. Both of two lower limbs were given a X-ray examination 10 weeks to assess if there were periprosthetic osteolysis and loosening of the plugs. All animals were killed 2 weeks afer the last injection. The distribution of polyethylene in the knee joint capsule was examined to understand if there were loosening of implants or tissue change around implants. Knee joint capsule tissues and periprosthetic tissues were examined by optical microscope.
  
  
  RESULTS
  Nine cases formed fibrous membrane and four cases formed new bone around prostheses in experiment group. Eleven cases formed new bone and two cases formed fibrous membrane in control group (P < 0.05) The X-ray results indicated that the plugs were in distal medulla of femur. There was no sign of periprosthetic osteolysis, implants loosening or new bone formation. Optical microscope study indicated that there were a lot of polyethylene particles inside the capsule. The polyethylene particles were surrounded by multinucleated foreign-body giant cells and fibroblast. In some cases, there were fibroblasts and fibrous tissue around plug. There were no polyethylene particles and multinucleated foreign-body giant cells around plug in the marrow. There were a lot of polyethylene particles on the joint surface. The bone surface that contacted multinucleated foreign-body giant cells was coarse.
  
  
  CONCLUSIONS
  Maximizing ultra high molecular weight polyethylene can restrain rabbit periprosthetic bone formation.
authors.affiliation: Department of Orthopaetics, First Affiliate Hospital of Guangzhou Medical College, Guangzhou Guangdong 510120, P R China. LuWeiJieGZ@163.com
authors.forename: Weijie
authors.initials: W
authors.lastname: Lu
authors.forename: Weiming
authors.initials: W
authors.lastname: Liao
authors.forename: Nansheng
authors.initials: N
authors.lastname: Yu
authors.forename: Xinyue
authors.initials: X
authors.lastname: Luo
authors.forename: Bo
authors.initials: B
authors.lastname: Bai
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Lin
authors.forename: Yingying
authors.initials: Y
authors.lastname: Gu
authors.forename: Muchang
authors.initials: M
authors.lastname: Liu
authors.forename: Guoqin
authors.initials: G
authors.lastname: Chen
authors.forename: Tong
authors.initials: T
authors.lastname: Yang
mesh_terms: D000818:Animals; D019643:Arthroplasty, Replacement; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005269:Femur / Q000187:drug effects / Q000473:pathology; D005549:Foreign-Body Reaction / Q000139:chemically induced; D017746:Joint Capsule / Q000187:drug effects / Q000473:pathology; D007595:Joint Prosthesis; D007719:Knee Joint / Q000187:drug effects / Q000473:pathology; D008297:Male; D010014:Osteolysis / Q000139:chemically induced; D011095:Polyethylenes / Q000494:pharmacology* / Q000633:toxicity; D011475:Prosthesis Failure; D011817:Rabbits
chemical_list: D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene