title: Marine natural products as anticancer drugs.
abstract: The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.
authors.affiliation: College of Pharmacy, Oregon State University, 15th and Jefferson Avenue, Corvallis, OR 97331, USA.
authors.forename: T Luke
authors.initials: TL
authors.lastname: Simmons
authors.forename: Eric
authors.initials: E
authors.lastname: Andrianasolo
authors.forename: Kerry
authors.initials: K
authors.lastname: McPhail
authors.forename: Patricia
authors.initials: P
authors.lastname: Flatt
authors.forename: William H
authors.initials: WH
authors.lastname: Gerwick
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology*; D047630:Depsipeptides / Q000737:chemistry / Q000494:pharmacology; D004149:Dioxoles / Q000737:chemistry / Q000494:pharmacology; D004988:Ethers, Cyclic / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides; D009792:Oceans and Seas; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin; D014443:Tyrosine / Q000031:analogs & derivatives; D000095662:Polyether Polyketides
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D047630:Depsipeptides; D004149:Dioxoles; D004988:Ethers, Cyclic; D007546:Isoquinolines; D018942:Macrolides; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin; D014443:Tyrosine; C070519:halichondrin B; D000095662:Polyether Polyketides