Endoscopic treatment of Barrett's oesophagus.
Barrett's oesophagus develops as a consequence of severe gastro-oesophageal reflux. The importance of Barrett's oesophagus lies in the small risk of developing high-grade dysplasia and subsequent adenocarcinoma. Because of poor treatment results in patients with advanced adenocarcinoma, surveillance of patients with Barrett's oesophagus for the development of dysplasia, although not uncontroversial, is widely practised in the gastroenterological community. The aim of surveillance is to detect adenocarcinoma in an early stadium where surgical cure is possible. In recent years several endoscopic treatments for both high-grade dysplasia and intramucosal adenocarcinoma have been developed. In this review some basic aspects of Barrett's oesophagus are discussed together with endoscopic treatments such as endoscopic mucosal resection, local thermal treatments and photodynamic therapy. Although surgical resection is probably the treatment of choice in fit patients, local endoscopic treatments should be considered in patients with high-grade dysplasia or intramucosal carcinoma who are unfit or unwilling to have surgery.
Veenendaal
R A
RA
Dept. Gastroenterology-Hepatology, Leiden University Medical Centre, Leiden, The Netherlands. R.A.Veenendaal@lumc.nl
Griffioen
G
G
Lamers
C B H W
CB
D001471:Barrett Esophagus / Q000175:diagnosis* / Q000628:therapy*; D004564:Electrocoagulation; D004945:Esophagoscopy; D006801:Humans; D010778:Photochemotherapy; D016896:Treatment Outcome