title: Sclerosing mucoepidermoid carcinoma of the oral cavity.
abstract: Sclerosing mucoepidermoid carcinoma (SMEC) with eosinophilia is a rare but distinctive tumor usually affecting the thyroid. SMEC involvement of salivary gland is exceptional, with only six cases in the literature. We present here the first case of an intermediate-grade SMEC, arising from the intraoral minor salivary glands. A particularly interesting finding is the cytoplasmic accumulation of eosinophilic hyaline granules in carcinoma cells, similar to aberrant zymogen-like granules previously described in salivary sclerosing polycystic adenosis.
authors.affiliation: Department of Pathology, Tsurumi University School of Dental Medicine, Tsurumi, Yokohama, Japan. ide-f@tsurumi-u.ac.jp
authors.forename: F
authors.initials: F
authors.lastname: Ide
authors.forename: K
authors.initials: K
authors.lastname: Obara
authors.forename: K
authors.initials: K
authors.lastname: Enatsu
authors.forename: K
authors.initials: K
authors.lastname: Mishima
authors.forename: I
authors.initials: I
authors.lastname: Saito
mesh_terms: D000236:Adenoma / Q000473:pathology; D000328:Adult; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology*; D003593:Cytoplasm / Q000648:ultrastructure; D004804:Eosinophils / Q000473:pathology; D005887:Gingival Neoplasms / Q000473:pathology*; D006801:Humans; D006818:Hyalin / Q000648:ultrastructure; D008297:Male; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology*; D012598:Sclerosis; D022142:Secretory Vesicles / Q000648:ultrastructure