title: Membrane disordering effects of beta-amyloid peptides.
abstract: The interaction of Abeta with synaptosomal plasma membranes decreases membrane fluidity. Using model membrane/liposome systems the interaction of Abeta with specific lipids (e.g. phospholipids, gangliosides, cholesterol) has been defined. The formation of the beta-sheet structure of Abeta when undergoing peptide aggregation is important for Abeta's membrane perturbing properties. This effect can be correlated with the peptide length of Abeta, the longer Abeta1-42 having the greatest effect on membrane fluidity and on neurotoxicity.
authors.affiliation: Department of Pharmacology, ZAFES, Biocenter University of Frankfurt, Germany.
authors.forename: Gunter P
authors.initials: GP
authors.lastname: Eckert
authors.forename: W G
authors.initials: WG
authors.lastname: Wood
authors.forename: W E
authors.initials: WE
authors.lastname: Müller
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure*; D002784:Cholesterol / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000648:ultrastructure*; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D011487:Protein Conformation; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D008563:Membrane Lipids; D002784:Cholesterol