Non-cholesterol sterols in serum, lipoproteins, and red cells in statin-treated FH subjects off and on plant stanol and sterol ester spreads.
BACKGROUND
Serum plant sterol levels are increased by consumption of statins and dietary plant sterols, and decreased by dietary plant stanols, but little is known about combination therapy of statin and plant sterols.


METHODS
We measured plant sterols in serum, lipoproteins, and red cells in subjects with familial hypercholesterolemia (FH) (n=18) treated with variable doses of statins off and on plant stanol (STA) and sterol ester (STE) spreads.


RESULTS
STA and STE spreads lowered LDL cholesterol approximately 15%. Plant sterols were decreased in serum, lipoproteins, and red cells by approximately 25% with STA and increased from 37% to 80% with STE, especially with high statin doses. The changes in serum were related to those in red cells. The baseline levels of serum plant sterols were negatively (r-range -0.639 to -0.935) and positively (r-range 0.526 to 0.598) correlated with the respective changes evoked by the STA and STE spreads.


CONCLUSIONS
STE reduces LDL cholesterol, but increases serum, lipoprotein, and red cell plant sterol levels in statin-treated FH subjects, while all the respective values are decreased with STA. Recent predictions that elevated serum plant sterols pose an increased coronary risk suggest that increases of serum plant sterol levels should be avoided, especially in atherosclerosis-prone individuals, such as subjects with FH.
Ketomäki
Anna
A
Division of Internal Medicine, Department of Medicine, University of Helsinki, Finland; Biomedicum Helsinki, P.O. Box 700, FIN-00029 HUS, Finland.
Gylling
Helena
H
Miettinen
Tatu A
TA
D000328:Adult; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004912:Erythrocytes; D004952:Esters; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000178:diet therapy*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013261:Sterols / Q000097:blood*
D004042:Dietary Fats, Unsaturated; D004952:Esters; D008074:Lipoproteins; D013261:Sterols