title: 1alpha,25(OH)2D3 induces capacitative calcium entry involving a TRPC3 protein in skeletal muscle and osteoblastic cells.
abstract: This work describes the involvement of TRPC proteins in capacitative calcium entry (CCE) induced by 1alpha,25-dihydroxy-vitamin-D3 [1alpha,25(OH)2D3] in chick skeletal muscle and in rat osteoblast-like cells (ROS 17/2.8) and the role of the vitamin D receptor (VDR) in this non-genomic rapid response mediated by the hormone. We propose that an endogenous TRPC3 protein mediates 1alpha,25(OH)2D3 modulation of CCE in these cells, which seems to implicate VDR-TRPC3 association and the participation of an INAD-like scaffold protein.
authors.affiliation: Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670 (B8000CN), Bahía Blanca, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Santillán
authors.forename: S
authors.initials: S
authors.lastname: Katz
authors.forename: C
authors.initials: C
authors.lastname: Buitrago
authors.forename: R
authors.initials: R
authors.lastname: Boland
mesh_terms: D000818:Animals; D002117:Calcitriol / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D002642:Chick Embryo; D007473:Ion Channels / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D010006:Osteoblasts / Q000378:metabolism*; D051381:Rats; D050052:TRPC Cation Channels
chemical_list: D015220:Calcium Channels; D007473:Ion Channels; D008565:Membrane Proteins; D050052:TRPC Cation Channels; C104603:TRPC3 cation channel; D002117:Calcitriol; D002118:Calcium