title: A new and known cytotoxic aryltetralin-type lignans from stems of Bursera graveolens.
abstract: A new 4alpha-aryltetralin-type lignan called burseranin (1) and a known analogous lignan picropolygamain (2) were isolated along with known triterpenes, lupeol and epi-lupeol from the methanol extract of stems of Bursera graveolens, which showed a remarkable inhibitory activity against human HT1080 fibrosarcoma cells. The whole structure of 1 was established based on combined spectral studies and the absolute structure for 2 was first confirmed by CD spectral evidence. In addition, cytotoxic activities of the stem (methanol) extract and its components are evaluated in this paper.
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, Osaka Japan. nakanisi@pharm.setsunan.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Inatomi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Murata
authors.forename: Kaori
authors.initials: K
authors.lastname: Shigeta
authors.forename: Naoki
authors.initials: N
authors.lastname: Iida
authors.forename: Akira
authors.initials: A
authors.lastname: Inada
authors.forename: Jin
authors.initials: J
authors.lastname: Murata
authors.forename: Miguel Angel Perez
authors.initials: MA
authors.lastname: Farrera
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Shogo
authors.initials: S
authors.lastname: Tajima
authors.forename: Naoto
authors.initials: N
authors.lastname: Oku
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031233:Bursera / Q000737:chemistry*; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000737:chemistry*; D008800:Mexico; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013764:Tetrahydronaphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D010936:Plant Extracts; D013764:Tetrahydronaphthalenes; C500864:burseranin