[Relationships between intravascular ultrasonographic findings and coronary risk factors in patients with normal coronary angiography].
OBJECTIVE
Indicators of ischemic heart disease were studied for the practice of preventive medicine.


METHODS
Intravascular ultrasonography was performed in 97 patients with no abnormalities by left anterior descending artery angiography. Coronary risk factors were evaluated based on the relationship between plaque formation and lipoprotein levels.


RESULTS
Plaque was observed in 81% of patients. The relationship between mean plaque area(%) and the low-density lipoprotein/high-density lipoprotein(LDL/HDL)ratio was examined. Mean plaque area(%) was significantly higher at LDL/HDL < or = 2.5 than at LDL/HDL > 2.5. The border of significant change level of mean plaque area(%)was LDL/HDL = 2.5. There was a good correlation between mean plaque area (%) and LDL/HDL (r = 0.65, p < 0.01). Mean plaque area (%) at LDL/HDL 2.5 was calculated at 15%. Patients with coronary risk factors had LDL/HDL lower than 2.5 at mean plaque area of 15%.


CONCLUSIONS
Maintaining LDL/HDL at 2.5 is very important for preventive medicine. However, LDL/HDL should be managed at under 2.5 in patients with coronary risk factors.
Noike
Hirofumi
H
Cardiovascular Center, Toho University School of Medicine, Sakura Hospital, Chiba. hfnoike@sakura.med.toho-u.ac.jp
Hitsumoto
Takashi
T
Sakurai
Takashi
T
Sugiyama
Yuko
Y
Sato
Shin
S
Iizuka
Takuo
T
Takahashi
Mao
M
Shimizu
Kazuhiro
K
Nakamura
Keijiro
K
Ohsawa
Hidefumi
H
D000367:Age Factors; D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000517:prevention & control; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000517:prevention & control*; D012307:Risk Factors; D018084:Ultrasonography, Interventional
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL