Urolithiasis associated with topiramate.
OBJECTIVE
Topiramate is a sulfamate-substituted monosaccharide anticonvulsant used as adjunctive therapy for intractable refractory seizures. It is report a case of topiramate-induced urolithiasis.


METHODS
A 35-year-old man presented with acute, right-sided, colicky flank pain. He denied hematuria or dysuria. He was in use of phenytoin, risperidone, phenobarbital, and topiramate. The total daily dose of topiramate was 375 mg. A CT scan showed a 7 x 1 mm curvilinear density at the right ureterovesical junction with proximal hydrouretronephrosis. He was managed with rigid ureteroscopic stone extraction and the calculus metabolic analysis revealed the stone was composed of carbonate apatite (70%), calcium oxalate dihydrate (20%), and calcium oxalate monohydrate (10%).


CONCLUSIONS
The present case typifies many features of topiramate-induced urolithiasis. Those who care for patients with urinary stone disease should be aware of this association.
Eggener
Scott
S
Department of Urology, Northwestern University Medical School, Chicago, Illinois 60611, USA.
Kim
Samuel C
SC
User
Herbert M
HM
Pazona
Joseph
J
Nadler
Robert B
RB
D015746:Abdominal Pain / Q000209:etiology; D000208:Acute Disease; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use*; D005632:Fructose / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012640:Seizures / Q000188:drug therapy; D000077236:Topiramate; D014545:Urinary Calculi / Q000139:chemically induced* / Q000601:surgery
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose