title: The influence of cyclic loading on gentamicin release from acrylic bone cements.
abstract: Antibiotic-loaded acrylic bone cement is widely used in total joint replacement to reduce infections. Walking results in cyclic loading, which has been suggested to stimulate antibiotic release. The goal of this study is to compare antibiotic release from cyclically loaded bone cement with the release from unloaded bone cement. Two models of the frontal aspect of a femoral stem were cemented with CMW 1 Radiopaque G, Palacos R-G and Palamed G. Both were immersed in water, and the gentamicin concentration in the water was monitored. One model was cyclically loaded at 5 Hz during immersion achieving physiological stresses in the bone cement mantle. After 10.8 x 10(6) cycles, initial release of gentamicin from Palamed G was increased significantly for loaded over unloaded, but not from CMW 1 Radiopaque G and Palacos R-G.
authors.affiliation: Department of Biomedical Engineering, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
authors.forename: Johannes G E
authors.initials: JG
authors.lastname: Hendriks
authors.forename: Daniëlle
authors.initials: D
authors.lastname: Neut
authors.forename: Jan G
authors.initials: JG
authors.lastname: Hazenberg
authors.forename: Gijsbertus J
authors.initials: GJ
authors.lastname: Verkerke
authors.forename: Jim R
authors.initials: JR
authors.lastname: van Horn
authors.forename: Henny C
authors.initials: HC
authors.lastname: van der Mei
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Busscher
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000379:methods*; D001843:Bone Cements / Q000627:therapeutic use*; D016503:Drug Delivery Systems / Q000379:methods*; D005839:Gentamicins / Q000008:administration & dosage*; D006622:Hip Prosthesis; D006801:Humans; D017053:Infection Control / Q000379:methods; D008422:Materials Testing; D016474:Weight-Bearing
chemical_list: D001843:Bone Cements; D005839:Gentamicins