[Synthetical evaluation of promoting effect of some kinds of transdermal enhancers with grey relational cluster method].
OBJECTIVE
Synthetical evaluation of promoting effect of some kinds of transdermal enhancers was carried through.


METHODS
Diclofenac sodium was used as model, and azone and l-menthol and synthetic borneol and olieic acid and essential oil from Cnidium monnieri were used as transdermal enhancers. Transdermal absorption experimentation of diclofenac sodium on the device of penetrating skins in vitro was done. Cumulation of permeation amount and penetrating rates and steady fluxes and lag times were observed, and grey relational cluster method was used to evaluate the promoting effect of some kinds of transdermal enhancers.


RESULTS
As for promoting effect on diclofenac sodium, azone and l-menthol were the best, and synthetic borneol and olieic acid ranked behind.


CONCLUSIONS
Grey relational cluster method can evaluate promoting effect objectively and fairly.
Wang
Hui
H
Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, China. gdwanghui@tom.com
Li
Xin
X
Xu
Bi-lian
BL
Xu
Wei-ming
WM
D000279:Administration, Cutaneous; D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D001892:Camphanes / Q000494:pharmacology; D016000:Cluster Analysis; D031048:Cnidium / Q000737:chemistry; D004008:Diclofenac / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008610:Menthol / Q000494:pharmacology*; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology; D011817:Rabbits; D012869:Skin Absorption / Q000187:drug effects*
D001381:Azepines; D001892:Camphanes; D009822:Oils, Volatile; D004008:Diclofenac; D008610:Menthol; C035229:laurocapram; C022871:isoborneol