[The influence of exogenous melanin on the development of female Wistar rats' posterity of first generation exposed to low doses at different dose rates during embryogenesis].
To research a radio-protective effect of melanin on the reproductive system during its creation the development of first generation posterity (900 descendants) of 125 pubertal female Wistar rats was examined after the single gamma-irradiation with a dose of 1 Gy (mean dose rate of 0.03 mGy/h), which they have been exposed to on the day ten of pregnancy, and the chronic gamma-irradiation with a total dose of 1 Gy (mean dose rate of 5.31 mGy/h) which they have been being exposed to during the first 10 days of pregnancy. The melanin of natural animal origin has the anti-radial effectiveness with the single irradiation increasing the number of alive newborn descendants in a litter and doubling their survival during the first 30 days after the birth. The melanin's effect is less expressed with the chronic irradiation.
Palyga
G F
GF
Zhavoronkov
L P
LP
Chibisova
O F
OF
Pavlova
L N
LN
Ivanov
V L
VL
Kolganova
O I
OI
D000818:Animals; D004622:Embryo, Mammalian / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays; D018811:Maternal Exposure; D008543:Melanins / Q000494:pharmacology*; D011247:Pregnancy; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D008543:Melanins; D011837:Radiation-Protective Agents