title: [Genetic Predictors of Unfavorable Course in High Risk Patients With Ischemic Heart Disease. Data of Follow-up for Two Years.].
abstract: Prognostic value of clinical parameters and polymorphisms of apo-B, apo-E, LPL, , PPARA, PPARG2 genes was studied in 154 patients with acute unstable angina. Duration of follow-up was 2 years. Diabetes (OR 3.29, 1.28-8.50, p=0.014), history of stroke (OR 6.11, 1.21-31.00, p=0.029), changes of terminal part of ventricular complex on ECG, recorded during acute phase of ischemic heart disease (OR 2.19, 1.01-4.57, p=0.046), and genotype II of polymorphic marker ID of apoB gene (OR 2.20, 1.06-4.57, p=0.027) were independent predictors of unfavorable course of ischemic heart disease. Thus genetic factors play a role not only in formation of coronary atherosclerosis but determine the course of ischemic heart disease.
authors.affiliation: Presidential Medical Center of Russia; ul. Marshala Timoshenko, 15, 121356 Moscow, Russia; State RF Research Center "Genetics", Moscow.
authors.forename: D A
authors.initials: DA
authors.lastname: Zateĭshchikov
authors.forename: O S
authors.initials: OS
authors.lastname: Chumakova
authors.forename: A A
authors.initials: AA
authors.lastname: Zateĭshchikova
authors.forename: I V
authors.initials: IV
authors.lastname: Zotova
authors.forename: L O
authors.initials: LO
authors.lastname: Minushkina
authors.forename: D A
authors.initials: DA
authors.lastname: Chudakova
authors.forename: V V
authors.initials: VV
authors.lastname: Nosikov
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
mesh_terms: D000789:Angina, Unstable; D001055:Apolipoproteins B; D003324:Coronary Artery Disease; D005500:Follow-Up Studies; D006801:Humans; D017202:Myocardial Ischemia; D012307:Risk Factors
chemical_list: D001055:Apolipoproteins B