[The effect of huanglian jiedu tang on Alzheimer's disease and its influence on cytokines].
OBJECTIVE
To investigate the effect of huanglian jiedu tang on Alzheimer' s disease, and its influence on cytokines.


METHODS
AD rats models were made by A beta injection, and then water-maze tests were made to investigate the study and memory ability. TNF-alpha, INF-gamma and IL-2 were examined by ELISA. After treatment with huanglian jiedu tang, the rats were evaluated again.


RESULTS
After A beta injection, the study and memory ability of the rats was decreased. By the treatment with huanglian jiedu tang, it was improved (P < 0.01); TNF-alpha, INF-gamma and IL-2 levels of AD rats were higher than those in control group (P < 0.01); after treatment the levels came down (P < 0.01).


CONCLUSIONS
Huanglian jiedu tang can improve the study and memory ability of AD rats by changing their immune state.
Fang
Qing
Q
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China.
Zhan
Xiao-ping
XP
Mo
Jian-ling
JL
Sun
Mei
M
D000544:Alzheimer Disease / Q000097:blood / Q000523:psychology*; D000818:Animals; D039323:Coptis / Q000737:chemistry; D016207:Cytokines / Q000097:blood*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D032062:Gardenia / Q000737:chemistry; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D008568:Memory / Q000187:drug effects*; D032102:Phellodendron / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D031363:Scutellaria / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; C061676:oren gedoku to; D007371:Interferon-gamma