2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity.
Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 microM of the IC(50) value.
Jung
Young-Sik
YS
Korea Research Institute of Chemical Technology, PO Box 107, Yusong, Taejon 305-606, Republic of Korea. ysjung@krict.re.kr
Joe
Bo-Young
BY
Cho
Sung Ju
SJ
Konishi
Yasuo
Y
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors; D006031:Glycosylation / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects*; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000975:Antioxidants; D016227:Benzoquinones; D017127:Glycation End Products, Advanced; D009285:Naphthoquinones