[Coagulation, inflammation and immune response -- an evolutionary conserved plan as cause for disseminated intravasal coagulation?].
The concomitant activation of the immune response and the coagulation system in response to injury represents a phylogenetic old and adaptive principle already present in the early eukaryotic development. The close connection between coagulation, inflammation, and immune defense has been conserved during evolution and can still be found in humans in a number of physiologic reactions to potentially detrimental effects.
Bierhaus
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A
Universität Heidelberg, Medizin I, Im Neuenheimer Feld 410, 69120 Heidelberg. E-Mail: angelika_bierhaus@med.uni-heidelberg.de
Nawroth
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PP
D005075:Biological Evolution; D001777:Blood Coagulation / Q000502:physiology*; D004211:Disseminated Intravascular Coagulation / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000502:physiology*; D007154:Immune System Diseases / Q000503:physiopathology*; D007249:Inflammation / Q000503:physiopathology*; D008955:Models, Cardiovascular; D018448:Models, Immunological