Effect of dexamethasone-eluting stents on systemic inflammatory response in patients with unstable angina pectoris or recent myocardial infarction undergoing percutaneous coronary intervention.
The effect of treatment with steroid-eluting stents on systemic inflammatory response was investigated in patients with unstable angina pectoris or recent myocardial infarction who underwent percutaneous intervention. Compared with controls, dexamethasone-eluting stents significantly reduced C-reactive protein peak levels 48 hours after the procedure; this effect persisted for 7 days and was particularly evident in patients with elevated (>/=3 mg/L) preprocedural C-reactive protein values. Patients receiving a dexamethasone-eluting stent had lower adverse events during follow-up.
Patti
Giuseppe
G
Department of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Rome, Italy.
Pasceri
Vincenzo
V
Carminati
Patrizia
P
D'Ambrosio
Andrea
A
Carcagnì
Addolorata
A
Di Sciascio
Germano
G
D000787:Angina Pectoris / Q000097:blood / Q000401:mortality / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000401:mortality / Q000628:therapy; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality / Q000628:therapy; D011446:Prospective Studies; D015607:Stents
D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D003907:Dexamethasone; D002097:C-Reactive Protein