Signaling mechanisms for regulation of chemotaxis.
Chemotaxis is a fascinating biological process, through which a cell migrates along a shallow chemoattractant gradient that is less than 5% difference between the anterior and posterior of the cell. Chemotaxis is composed of two independent, but interrelated processes-motility and directionality, both of which are regulated by extracellular stimuli, chemoattractants. In this mini-review, recent progresses in the understanding of the regulation of leukocyte chemotaxis by chemoattractant signaling are reviewed.
Wu
Dianqing
D
Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. dwu@neuron.uchc.edu
D000818:Animals; D019070:Cell Lineage; D002465:Cell Movement; D002633:Chemotaxis; D005786:Gene Expression Regulation; D006801:Humans; D007962:Leukocytes / Q000166:cytology; D008954:Models, Biological; D009504:Neutrophils / Q000166:cytology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism
D019869:Phosphatidylinositol 3-Kinases; D020764:cdc42 GTP-Binding Protein