title: Adrenocorticotropic hormone production in breast cancer.
abstract: Presence of adrenocorticotropic hormone (ACTH) was investigated in tissues from 150 cases of primary breast cancer. ACTH peptides were detected in 16.7% cases and ACTH expression was higher in post-menopausal cancers. A significant association was noticed between the presence of ACTH and the positive estrogen receptor (ER) status of tumors. The study indicated a probable role of these ectopic ACTH peptides in steroid hormone related pathology of breast cancer.
authors.affiliation: Protein Research Laboratory (Department of Biosciences), Jamia Millia Islamia, New Delhi 110 025, India.
authors.forename: Nitesh Kumar
authors.initials: NK
authors.lastname: Poddar
authors.forename: Renuka
authors.initials: R
authors.lastname: Saha
authors.forename: Suresh
authors.initials: S
authors.lastname: Hedau
authors.forename: Amitabha
authors.initials: A
authors.lastname: Ray
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011960:Receptors, Estrogen / Q000096:biosynthesis
chemical_list: D011960:Receptors, Estrogen; D000324:Adrenocorticotropic Hormone