title: Bioactive pyranoxanthones from the roots of Calophyllum blancoi.
abstract: Phytochemical investigation of the roots of Calophyllum blancoi growing in Taiwan resulted in the isolation of three new pyranoxanthones, blancoxanthone (1), acetyl blancoxanthone (2) and 3-hydroxyblancoxanthone (3), in addition to two known pyranoxanthones, pyranojacaeubin (4) and caloxanthone (5). Structural characterization of the isolated compounds was determined by spectral analyses especially 2-D NMR. Biological study of the isolated xanthones revealed that blancoxanthone (1) exhibited significant anti-coronavirus activity.
authors.affiliation: Institute of Marine Resources, National Sun Yat-sen University, Taiwan. ycshen@mail.nsysu.edu.tw
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Li-Tang
authors.initials: LT
authors.lastname: Wang
authors.forename: Ashraf Taha
authors.initials: AT
authors.lastname: Khalil
authors.forename: Lien Chai
authors.initials: LC
authors.lastname: Chiang
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Cheng
mesh_terms: D000107:Acetylation; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029759:Calophyllum / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D017934:Coronavirus / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000821:virology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D011714:Pyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013624:Taiwan; D010948:Viral Plaque Assay; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C500867:3-hydroxyblancoxanthone; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D011714:Pyrans; D044004:Xanthones; C500868:acetyl blancoxanthone; C500869:blancoxanthone