Relationship between intracranial granulomas and cerebrospinal fluid levels of gamma interferon and interleukin-10 in patients with tuberculous meningitis.
Cerebrospinal fluid gamma interferon (IFN-gamma) and interleukin-10 levels in 39 patients with tuberculous meningitis were serially measured. Cytokine levels did not predict intracranial granuloma (IG) development, but IFN-gamma levels in the top quartile after 1 month of therapy were highly associated (odds ratio = 18) with detection of an IG by computed tomography scanning.
Mansour
Adel M
AM
University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Frenck
Robert W
RW
Darville
Toni
T
Nakhla
Isabelle A
IA
Wierzba
Thomas F
TF
Sultan
Yehia
Y
Bassiouny
Magdy I
MI
McCarthy
Kathryn
K
Jacobs
Richard F
RF
D000293:Adolescent; D000328:Adult; D005260:Female; D006099:Granuloma / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000134:cerebrospinal fluid*; D016753:Interleukin-10 / Q000134:cerebrospinal fluid*; D008297:Male; D011379:Prognosis; D016862:Tuberculoma, Intracranial / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D014390:Tuberculosis, Meningeal / Q000276:immunology*
D016753:Interleukin-10; D007371:Interferon-gamma