title: Chronic actinic dermatitis associated with adult T-cell leukemia.
abstract: We describe a patient with chronic actinic dermatitis that occurred with the progress of adult T-cell leukemia. Immunohistochemically, CD8 + T cells, but not CD4 + cells, predominantly infiltrated the lichenoid lesional skin, indicating that the eruption was induced by reactive, normal CD8 + T cells but not adult T-cell leukemia cells. Our patient suggests that chronic actinic dermatitis may occur in association with the advanced human T-lymphotrophic virus-I infectious disorder.
authors.affiliation: Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. k-sugita@med.uoeh-u.ac.jp
authors.forename: Kazunari
authors.initials: K
authors.lastname: Sugita
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Shimauchi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Tokura
mesh_terms: D000368:Aged; D016207:Cytokines / Q000097:blood; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000276:immunology; D008297:Male; D010787:Photosensitivity Disorders / Q000209:etiology* / Q000276:immunology; D054398:Receptors, CCR4; D019707:Receptors, Chemokine / Q000032:analysis; D016176:T-Lymphocyte Subsets
chemical_list: C515354:CCR4 protein, human; D016207:Cytokines; D054398:Receptors, CCR4; D019707:Receptors, Chemokine