Effects of inhaling the vapor of Lavandula burnatii super-derived essential oil and linalool on plasma adrenocorticotropic hormone (ACTH), catecholamine and gonadotropin levels in experimental menopausal female rats.
The effects of inhaling the vapor of Lavandula burnatii super-derived essential oil and one of the main components of lavender oil, linalool on plasma adrenocorticotropic hormone (ACTH), catecholamine and gonadotropin levels in menopausal model rats under ether-inhalation were studied. The increased plasma ACTH levels induced by ether-inhalation tended to decrease by pre-inhalation of Lavandula burnetii super and linalool vapor was induced the decrease of ACTH level. The decrease in adrenaline, noradrenaline and dopamine levels induced by ether-inhalation tended to recover, especially, the dopamine level significantly recovered to the normal level by the inhalation of Lavandula burnetii super and linalool vapor. However, the increased plasma gonadotropin levels in ovariectomized retired female rats (menopausal model rats) was significantly decreased by the inhalation of linalool. These results suggest that lavender oil or one of the main components, linalool may contribute to relieving tension and may be applicable to the treatment of menopausal disorders in human beings.
Yamada
Kenji
K
Tokyo University of Pharmacy and Life Science, School of Pharmacy, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. kenjiy@ps.toyaku.ac.jp
Mimaki
Yoshihiro
Y
Sashida
Yutaka
Y
D000080462:Acyclic Monoterpenes; D000280:Administration, Inhalation; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D002395:Catecholamines / Q000097:blood*; D005260:Female; D006062:Gonadotropins / Q000097:blood*; D006168:Guinea Pigs; D027523:Lavandula; D008593:Menopause / Q000097:blood / Q000187:drug effects*; D039821:Monoterpenes / Q000008:administration & dosage*; D009822:Oils, Volatile / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D014835:Volatilization
D000080462:Acyclic Monoterpenes; D002395:Catecholamines; D006062:Gonadotropins; D039821:Monoterpenes; D009822:Oils, Volatile; D000324:Adrenocorticotropic Hormone; C018584:linalool