[Influence of botulinum toxin on myogenous facial pain].
OBJECTIVE
Can chronic pain of the masticatory muscles be positively affected by low dose injection of botulinum toxin (BTX-A)?


METHODS
Twenty patients suffering chronic myofacial pain were questioned and examined after injection of 25-50 U Dysport into the affected muscles over a period of 8 weeks.


RESULTS
Four weeks after injection of BTX-A patients reported a significant reduction of pain (p <0.001, paired t-test. Power of performed test with alpha 0.050:1.000). Then the pain remained constant over the next 4 weeks. Concurrently a significant increase of mandubular range of movement was observed (p <0,05, Wilcoxon signed rank test).


CONCLUSIONS
Even though lacking placebo control the findings suggest that patients suffering chronic myofacial pain may benefit from injection of low dose BTX-A into the affected muscles.
Seedorf
H
H
Abteilung für zahnärztliche Prothetik, Klinik und Poliklinik für Zahn- Mund- und Kieferheilkunde der Univ.-Klinikums Hamburg-Eppendorf, Hamburg. seedorf@uke.uni-hamburg.de
Leuwer
R
R
Bussopulos
A
A
Fenske
C
C
Jüde
H D
HD
D000328:Adult; D001905:Botulinum Toxins / Q000627:therapeutic use*; D005157:Facial Pain / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008410:Masticatory Muscles / Q000187:drug effects / Q000503:physiopathology*
D001905:Botulinum Toxins