title: AC133/CD133/Prominin-1.
abstract: Prominin-1, originally found on neuroepithelial stem cells in mice, is a five transmembrane domain cell-surface glycoprotein that localizes to membrane protrusions. Its homologue human Prominin-1 was first isolated from hematopoietic stem cells by a monoclonal antibody recognizing a specific epitope designated as AC133 (CD133). Transcription of Prominin-1 is driven by five tissue-specific alternative promoters resulting in the formation of differentially spliced mRNA isoforms. Prominin-1 is expressed on different types of stem cells, but it is not known if it plays a significant role in key stem cell functional features. Although the biological function of Prominin-1 is not well understood, the AC133 epitope currently serves as a useful marker for the isolation of hematopoietic and endothelial progenitor cells.
authors.affiliation: Weill Medical College of Cornell University, Department of Genetic Medicine, 1300 York Avenue, New York, NY 10021, USA. svs2001@med.cornell.edu
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Shmelkov
authors.forename: Ryan
authors.initials: R
authors.lastname: St Clair
authors.forename: David
authors.initials: D
authors.lastname: Lyden
authors.forename: Shahin
authors.initials: S
authors.lastname: Rafii
mesh_terms: D000071916:AC133 Antigen; D017398:Alternative Splicing; D015703:Antigens, CD; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D006868:Hydrolysis; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides; C000606024:Prom1 protein, mouse; D012333:RNA, Messenger