Radical trifluoromethylation of titanium ate enolate.
The radical trifluoromethylation of ketone titanium ate enolates gave alpha-CF3 ketones in good yields. The use of excess amount of LDA and Ti(OiPr)4 in the preparation of titanium ate enolates is the key to the efficient radical trifluoromethylation. [reaction: see text]
Itoh
Yoshimitsu
Y
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan.
Mikami
Koichi
K
D004952:Esters; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D014025:Titanium
D004952:Esters; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D009942:Organometallic Compounds; C511647:titanium ate enolate; C013314:trifluoromethyl hypofluorite; D014025:Titanium