Hydroxylated metabolites of polychlorinated biphenyls inhibit thyroid-hormone-dependent extension of cerebellar Purkinje cell dendrites.
Thyroid hormones (THs) are important for brain development, and polychlorinated biphenyl (PCB) accumulation in humans is a serious problem because PCBs may affect TH functions. To determine the effects of hydroxylated metabolites of PCBs (OH-PCBs) on brain development, we performed mouse cerebellar culture assays. 4-OH-2',3,3',4',5'-pentachlorobiphenyl and 4-OH-2',3,3',4',5,5'-hexachlorobiphenyl significantly inhibited the TH-dependent extension of Purkinje cell dendrites even at 5 x 10(-11) M and 5 x 10(-12) M, respectively. OH-PCBs may disturb TH-dependent brain development.
Kimura-Kuroda
Junko
J
Department of Brain Structure, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183-8526, Japan. jkkuro@tmin.ac.jp
Nagata
Isao
I
Kuroda
Yoichiro
Y
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology; D003712:Dendrites / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008807:Mice, Inbred BALB C; D009433:Neural Inhibition / Q000187:drug effects*; D011078:Polychlorinated Biphenyls / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011689:Purkinje Cells / Q000166:cytology* / Q000187:drug effects*; D013963:Thyroid Hormones / Q000502:physiology*
C501474:4-OH-2',3,3',4',5'-pentachlorobiphenyl; C501475:4-OH-2',3,3',4',5,5'-hexachlorrobiphenyl; D013963:Thyroid Hormones; D011078:Polychlorinated Biphenyls