title: COX-2 inhibitors--lessons in drug safety.
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Psaty
authors.forename: Curt D
authors.initials: CD
authors.lastname: Furberg
mesh_terms: D002318:Cardiovascular Diseases / Q000139:chemically induced*; D000068579:Celecoxib; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D017277:Drug Approval / Q000331:legislation & jurisprudence*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects; D007783:Lactones / Q000009:adverse effects; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases; D011643:Publishing / Q000592:standards; D011720:Pyrazoles / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic / Q000592:standards*; D012107:Research Design; D013449:Sulfonamides / Q000009:adverse effects; D013450:Sulfones / Q000009:adverse effects; D014481:United States; D014486:United States Food and Drug Administration / Q000458:organization & administration*; D000096926:Benzenesulfonamides
chemical_list: D000068579:Celecoxib; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007555:Isoxazoles; D007783:Lactones; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases; D011720:Pyrazoles; D013449:Sulfonamides; D013450:Sulfones; C116926:rofecoxib; C406224:valdecoxib; D000096926:Benzenesulfonamides; C409945:parecoxib; C496540:PTGS2 protein, human