Pursuing cardiac progenitors: regeneration redux.
Recent studies have questioned the accepted dogma that the regenerative capacity of the heart following injury is limited. Several apparently distinct populations of resident cardiac progenitor cells may have the potential to regenerate functional heart muscle. Despite this progress, the physiologic role and therapeutic potential of cardiac resident progenitor cells remain unclear.
Parmacek
Michael S
MS
University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA.
Epstein
Jonathan A
JA
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D032386:Myoblasts, Cardiac / Q000166:cytology / Q000378:metabolism*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism*; D012038:Regeneration / Q000502:physiology*
D015415:Biomarkers