title: Corcoran Lecture. Cardiovascular genomics and oxidative stress.
abstract: The majority of modifiable cardiovascular risk factors are complex, polygenic, or at least oligogenic traits, with genetic and environmental determinants playing important roles in disease risk and its phenotypic expression. The Human Genome Project and subsequent mouse and rat genome data have provided powerful tools to commence the dissection of genetic determinants of hypertension and other cardiovascular risk factors. Despite several new methodologies such as genome-wide scans, genome-wide gene expression profiling, and proteomic screens, it is fair to say that the progress of genetic studies designed as nonhypothesis driven has been relatively slow. On the other hand, several interesting candidate pathways have been identified, where investigators allowed for hypothesis-driven functional studies. One example of such pathway is vascular oxidative stress with its extensive network of genes and proteins, many with proven contributions to cardiovascular disease. Therefore, in parallel to genome-wide or proteome-wide studies, it will be constructive to pursue "pathwayomics" defined here as functional studies of a candidate pathway for disease pathogenesis.
authors.affiliation: BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, Western Infirmary, University of Glasgow, Scotland, UK. ad7e@clinmed.gla.ac.uk
authors.forename: Anna F
authors.initials: AF
authors.lastname: Dominiczak
authors.forename: Delyth
authors.initials: D
authors.lastname: Graham
authors.forename: Martin W
authors.initials: MW
authors.lastname: McBride
authors.forename: Nick J R
authors.initials: NJ
authors.lastname: Brain
authors.forename: Wai Kwong
authors.initials: WK
authors.lastname: Lee
authors.forename: Fadi J
authors.initials: FJ
authors.lastname: Charchar
authors.forename: Maciej
authors.initials: M
authors.lastname: Tomaszewski
authors.forename: Christian
authors.initials: C
authors.lastname: Delles
authors.forename: Carlene A
authors.initials: CA
authors.lastname: Hamilton
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000378:metabolism*; D002874:Chromosome Mapping; D004195:Disease Models, Animal; D016678:Genome; D023281:Genomics; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D051379:Mice; D018384:Oxidative Stress / Q000235:genetics*; D040641:Quantitative Trait Loci; D051381:Rats