Under-recognised paradox of neuropathy from rapid glycaemic control.
Insulin induced neuropathy has been reported previously in people with diabetes treated with insulin, and subsequently reported in patients with insulinomas. However, neuropathy caused by rapid glycaemic control in patients with poorly controlled diabetes with chronic hyperglycaemia is not a widely recognised entity among clinicians worldwide. It is expected that this phenomenon of paradoxical complication of neuropathy in the face of drastic decreases in glycosylated haemoglobin concentrations will assume greater importance with clinicians achieving glycaemic targets at a faster pace than before.
Leow
M K S
MK
Department of Endocrinology, Division of Medicine, Tan Tock Seng Hospital, Singapore. mleowsj@massmed.org
Wyckoff
J
J
D001786:Blood Glucose / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000097:blood / Q000139:chemically induced*; D006442:Glycated Hemoglobin / Q000187:drug effects*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy*; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced*; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D007328:Insulin / Q000009:adverse effects*; D012307:Risk Factors
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin