title: Middle ear carcinoma originating from a primary acquired cholesteatoma: a case report.
abstract: OBJECTIVE
  To describe middle ear carcinoma originating from the matrix of primary acquired cholesteatoma in a 43-year-old man and to discuss the relationship between middle ear carcinoma and cholesteatoma.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Department of Otolaryngology, Head and Neck Surgery of Niigata University Medical and Dental Hospital, which is a tertiary care center, Niigata, Japan.
  
  
  METHODS
  A 43-year-old man demonstrated symptoms resembling those of cholesteatoma: facial palsy, gradually progressive hearing loss, and chronic draining of the right ear. Other objective findings also supported a finding of cholesteatoma, but a computed tomographic scan and magnetic resonance imaging scan showed a well-enhanced mass and extensive bony erosion in the middle ear. At surgery, a granulous tumor in the mastoid cavity was diagnosed as squamous cell carcinoma, and closely coexisting cholesteatoma was found. Surgical specimen demonstrated carcinoma and cholesteatoma in the same field.
  
  
  METHODS
  Radiation and chemotherapy were performed followed-up by mastoidectomy.
  
  
  CONCLUSIONS
  Because middle ear carcinoma has a poor prognosis, it is important to detect lesions early. It is necessary to consider that middle ear carcinoma arises from not only chronic otitis media or surgical invasion but also from primary acquired cholesteatoma.
authors.affiliation: Department of Otolaryngology, Niigata University Faculty of Medicine, Niigata, Japan. kunny@med.niigata-u.ac.jp
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Katsuro
authors.initials: K
authors.lastname: Sato
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Sato
authors.forename: Sugata
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D018424:Cholesteatoma, Middle Ear / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D004428:Ear Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D004432:Ear, Middle / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008416:Mastoid / Q000473:pathology; D038781:Otoscopy; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D014057:Tomography, X-Ray Computed