title: Genomic discovery reveals a molecular system for resistance to oxidative and endoplasmic reticulum stress in cultured glioma.
abstract: Oxygen is required for respiration and the energetic processes that enable aerobic life. Reactive oxygen species and free radicals, by-products of oxygen use, cause DNA damage and induce endoplasmic reticulum (ER) stress and apoptosis. However, rapidly multiplying cancer cells are resistant to ER and oxidative stress-induced apoptosis. The present article reports the results of highly specific genome-scale expression discovery used to identify genes differentially expressed in cultured glioma cells vs normal brain tissue. The discovered states of expression reveal a cohesive molecular system that protects rapidly growing glioma cells from ER and oxidative stress-induced apoptosis.
authors.affiliation: Department of Neurological Sciences, Section of Neuro-Oncology, Rush University Medical Center, Chicago, IL 60612, USA. hfathall@rush.edu
authors.forename: Hassan M
authors.initials: HM
authors.lastname: Fathallah-Shaykh
mesh_terms: D001921:Brain / Q000502:physiology; D045744:Cell Line, Tumor; D004721:Endoplasmic Reticulum / Q000235:genetics*; D015870:Gene Expression / Q000502:physiology; D005910:Glioma / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D046228:Microarray Analysis / Q000379:methods; D018384:Oxidative Stress / Q000235:genetics*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species