Gene overexpression in pancreatic adenocarcinoma: diagnostic and therapeutic implications.
Pancreatic cancer is the deadliest of cancers, and effective diagnostic and therapeutic strategies are lacking. Global gene expression profiling holds promise for improved diagnosis and treatment. Knowledge of the location and timing of gene overexpression and the function of these genes, including their effects on signaling pathways, is important. These data may be used to develop histologic and serum biomarkers as well as to develop immunotherapeutic, molecular targeting, and gene therapy strategies. We have compiled a list of overexpressed genes in pancreatic cancer for which overexpression was confirmed by reverse transcriptase polymerase chain reaction, immunohistochemistry, and/or in situ hybridization following initial identification by global gene expression profiling. The techniques used in the determination of overexpression, problems encountered in global gene expression profiling, and the diagnostic and therapeutic implications of overexpression are discussed. The S100 gene family, mesothelin, prostate stem cell antigen, and 14-3-3 sigma, may have important clinical implications in pancreatic cancer diagnosis and treatment.
Rodriguez
Joel A
JA
Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin Street, Houston, Texas 77030, USA. jr131072@bcm.tmc.edu
Li
Min
M
Yao
Qizhi
Q
Chen
Changyi
C
Fisher
William E
WE
D048948:14-3-3 Proteins; D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000235:genetics; D005092:Exonucleases / Q000235:genetics; D005095:Exoribonucleases; D058851:GPI-Linked Proteins; D015870:Gene Expression / Q000502:physiology*; D020869:Gene Expression Profiling; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D000090204:Mesothelin; D009363:Neoplasm Proteins / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D009418:S100 Proteins / Q000235:genetics
D048948:14-3-3 Proteins; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; C110843:PSCA protein, human; D009418:S100 Proteins; D005092:Exonucleases; D005095:Exoribonucleases; C413442:SFN protein, human; D000090204:Mesothelin