title: Motion-corrected free-breathing delayed enhancement imaging of myocardial infarction.
abstract: Following administration of Gd-DTPA, infarcted myocardium exhibits delayed enhancement and can be imaged using an inversion-recovery sequence. A conventional segmented acquisition requires a number of breath-holds to image the heart. Single-shot phase-sensitive inversion-recovery (PSIR) true-FISP may be combined with parallel imaging using SENSE to achieve high spatial resolution. SNR may be improved by averaging multiple motion-corrected images acquired during free breathing. PSIR techniques have demonstrated a number of benefits including consistent contrast and appearance over a relatively wide range of inversion recovery times (TI), improved contrast-to-noise ratio, and consistent size of the enhanced region. Comparison between images acquired using segmented breath-held turbo-FLASH and averaged, motion-corrected, free-breathing true-FISP show excellent agreement of measured CNR and infarct size. In this study, motion correction was implemented using image registration postprocessing rather than navigator correction of individual frames. Navigator techniques may be incorporated as well.
authors.affiliation: Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, 10 Center Drive, MSC-1061, Building 10, Room B1D416, Bethesda, MD 20892, USA. kellman@nih,gov
authors.forename: Peter
authors.initials: P
authors.lastname: Kellman
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Larson
authors.forename: Li-Yueh
authors.initials: LY
authors.lastname: Hsu
authors.forename: Yiu-Cho
authors.initials: YC
authors.lastname: Chung
authors.forename: Orlando P
authors.initials: OP
authors.lastname: Simonetti
authors.forename: Elliot R
authors.initials: ER
authors.lastname: McVeigh
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Arai
mesh_terms: D000465:Algorithms; D016477:Artifacts; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009038:Motion; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D012119:Respiration
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA