title: Recurrent colonization of successively implanted tracheoesophageal vocal prostheses by a member of the Fusarium solani species complex.
abstract: Tracheoesophageal vocal prostheses (TVP) in laryngectomized patients commonly deteriorate due to overgrowth by yeasts, particularly Candida species. We describe the first case of colonization of such devices by a member of the Fusarium solani species complex in a patient with a history of glottal carcinoma. Three isolates, from three prostheses, were found morphologically consistent with the traditional picture of F. solani. Ribosomal sequence analysis showed that the isolates belonged to a distinct, as yet apparently unnamed phylogenetic species within the F. solani species complex. This species, one of two distinct genetic types (genotype 2) traditionally considered part of the plant-pathogenic subtaxon Fusarium solani f. sp. radicicola, has not previously been identified as an agent of human or animal disease, although it is closely related to a known etiologic agent of mycetoma, an Acremonium-like species recently renamed Fusarium falciforme. Sequence and multisatellite M13 polymorphism analysis revealed no distinctions among the case isolates. Production of cyclosporine was detected for all three case isolates.
authors.affiliation: Laboratory for Pharmaceutical Microbiology, University of Ghent, Harelbekestraat 72, B-9000 Ghent, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Honraet
authors.forename: M M
authors.initials: MM
authors.lastname: De Vos
authors.forename: R C
authors.initials: RC
authors.lastname: Summerbell
authors.forename: I
authors.initials: I
authors.lastname: van Kempen
authors.forename: S
authors.initials: S
authors.lastname: De Saeger
authors.forename: H
authors.initials: H
authors.lastname: Vermeersch
authors.forename: C
authors.initials: C
authors.lastname: Van Peteghem
authors.forename: H J
authors.initials: HJ
authors.lastname: Nelis
mesh_terms: D000368:Aged; D003470:Culture Media; D016572:Cyclosporine / Q000378:metabolism; D004271:DNA, Fungal / Q000032:analysis; D005670:Fusarium / Q000145:classification* / Q000235:genetics / Q000254:growth & development* / Q000302:isolation & purification; D006801:Humans; D007831:Larynx, Artificial / Q000009:adverse effects / Q000382:microbiology*; D008297:Male; D008969:Molecular Sequence Data; D009181:Mycoses / Q000382:microbiology; D010802:Phylogeny; D019736:Prostheses and Implants / Q000009:adverse effects / Q000382:microbiology*; D012008:Recurrence; D017422:Sequence Analysis, DNA
chemical_list: D003470:Culture Media; D004271:DNA, Fungal; D016572:Cyclosporine