title: Pseudomonas aeruginosa endogenous endophthalmitis with choroidal abscess in a patient with cystic fibrosis.
abstract: OBJECTIVE
  To describe the clinical presentation, management, and outcome of a case of endogenous intraocular infection due to Pseudomonas aeruginosa in a patient with cystic fibrosis (CF).
  
  
  METHODS
  The authors describe a case of an adult patient with CF who developed an intraocular infection by P. aeruginosa.
  
  
  RESULTS
  Diagnosis was confirmed by culture of purulent fluid obtained by transcleral incision and drainage. The infection persisted in spite of aggressive surgical intervention including extensive endoresection of the visibly affected retina and choroid and multiple administrations of appropriate intraocular, subconjunctival, and systemic antibiotics. Eventually, the eye became blind and painful and was enucleated.
  
  
  CONCLUSIONS
  Endogenous intraocular infection by P. aeruginosa can occur in patients with CF who have not undergone lung transplantation. An infection of this type may be impossible to eradicate by aggressive surgical intervention and appropriate antibiotic therapy.
authors.affiliation: Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. william.walker.motley@cchmc.org
authors.forename: William W
authors.initials: WW
authors.lastname: Motley
authors.forename: James J
authors.initials: JJ
authors.lastname: Augsburger
authors.forename: Robert K
authors.initials: RK
authors.lastname: Hutchins
authors.forename: Susan
authors.initials: S
authors.lastname: Schneider
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Boat
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D000328:Adult; D000900:Anti-Bacterial Agents; D015862:Choroid Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D003131:Combined Modality Therapy; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D009877:Endophthalmitis / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D015353:Eye Enucleation; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D008297:Male; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D014821:Vitrectomy
chemical_list: D000900:Anti-Bacterial Agents