[Bilateral frontal polymicrogyria and Ehlers-Danlos syndrome].
The authors describe the case of a six-year-old girl with Ehlers-Danlos syndrome associated to bilateral symmetrical frontal polymicrogyria. Several extracellular matrix components, including collagen, are directly implicated in the neuronal migration. We think that a defect in collagen or in another extracellular matrix protein during fetal development could result in this association.
Ezzeddine
H
H
Service de pédiatrie A, hôpital Manchester, 45 avenue Manchester, 08011 Charleville-Mézières cedex, France.
Sabouraud
P
P
Eschard
C
C
El Tourjuman
O
O
Bednarek
N
N
Motte
J
J
D002648:Child; D003094:Collagen / Q000378:metabolism; D004535:Ehlers-Danlos Syndrome / Q000150:complications*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D017628:Microglia / Q000473:pathology*
D003094:Collagen