Repeated swim stress leads to down-regulation of vesicular monoamine transporter 2 in rat brain nucleus accumbens and striatum.
We assessed the impact of chronic swim stress in rats (daily for 3 weeks) on vesicular monoamine transporter 2 (VMAT2) in the nucleus accumbens and striatum. Exposure to repeated swim stress resulted in significant reduction in VMAT2 density in nucleus accumbens (20%, p<0.01) and striatum subregions (21-38%, p<0.001). The down-regulation of VMAT2 in this dopaminergic regions may serve as an adaptatory mechanism in the response to prolonged stress, and may be relevant to chronic stress-induced depression.
Zucker
Michal
M
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
Weizman
Abraham
A
Rehavi
Moshe
M
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism* / Q000502:physiology; D015536:Down-Regulation / Q000502:physiology*; D008297:Male; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D049990:Membrane Transport Modulators; D026901:Membrane Transport Proteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D009714:Nucleus Accumbens / Q000378:metabolism* / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D011485:Protein Binding / Q000502:physiology; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism* / Q000523:psychology; D013550:Swimming / Q000502:physiology; D013997:Time Factors; D050492:Vesicular Biogenic Amine Transport Proteins; D050493:Vesicular Monoamine Transport Proteins
D008562:Membrane Glycoproteins; D049990:Membrane Transport Modulators; D026901:Membrane Transport Proteins; C493454:Slc18a2 protein, rat; D050492:Vesicular Biogenic Amine Transport Proteins; D050493:Vesicular Monoamine Transport Proteins