title: [Polarographic catalytic wave of clarithromycin and its applications].
abstract: OBJECTIVE
  To develop a new method for the determination of clarithromycin.
  
  
  METHODS
  The catalytic wave of clarithromycin in the presence of K2S2O8 was used for improving the analytical sensitivity. The rapid determination of clarithromycin has been carried out by linear single sweep polarography.
  
  
  RESULTS
  The reduction wave of clarithromycin appeared at ca. -0.79 V (vs SCE) in 0.24 mol x L(-1) KH2PO4-Na2HPO4 (pH 6.81) supporting electrolyte, which was ascribed to the reduction of carbonyl group on C-9 position. In the presence of 0.01 mol x L(-1) K2S2O8, the reduction wave was catalyzed to produce a parallel catalytic wave. The peak current of the catalytic wave was ca. Twenty times higher than that of the corresponding reduction wave. Based on the catalytic wave, a new method for the determination of clarithromycin has been proposed. The peak current of the catalytic wave was rectilinear to clarithromycin concentration in the range of 4.0 x 10(-7)-5.0 x 10(-5) mol x L(-1). The detection limit was 2.0 x 10(-7) mol x L(-1).
  
  
  CONCLUSIONS
  The proposed method could be used for the direct determination of clarithromycin in pharmaceuticals and urine without preliminary separation.
authors.affiliation: Department of Chemistry, Shangqiu Normal College, Shangqiu 476000, China.
authors.forename: Huai-ling
authors.initials: HL
authors.lastname: Ma
authors.forename: Mao-tian
authors.initials: MT
authors.lastname: Xu
authors.forename: Jun-feng
authors.initials: JF
authors.lastname: Song
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry; D002384:Catalysis; D017291:Clarithromycin / Q000032:analysis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D011048:Polarography / Q000379:methods*; D017680:Potassium Compounds / Q000737:chemistry; D013431:Sulfates / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D017680:Potassium Compounds; D013431:Sulfates; C009007:potassium persulfate; D017291:Clarithromycin