PIK3CA mutations in advanced ovarian carcinomas.
PIK3CA belongs to the phosphatidylinositol 3-kinases (PI3Ks) family, which play an important role in proliferation, adherence, transformation and cell survival through the PI3K/AKT signaling pathway. Somatic activating mutations of this gene have recently been detected in several types of cancers. In the present study, 109 advanced ovarian carcinomas were analyzed for PIK3CA mutations in exon 9 and exon 20 by direct sequencing. Activating missense mutations were observed in 4 of the 109 tumors in addition to one variant leading no change of the PIK3CA protein. Two of the cases with mutations were mucinous and clear cell tumors, suggesting that PIK3CA mutations are more common in these rare histological types.
Wang
Yun
Y
Department of Gynecologic Oncology, The Norwegian Radium Hospital, N-0310, Oslo, Norway.
Helland
Aslaug
A
Holm
Ruth
R
Kristensen
Gunnar B
GB
Børresen-Dale
Anne-Lise
AL
D018262:Adenocarcinoma, Clear Cell / Q000235:genetics; D000368:Aged; D002277:Carcinoma / Q000235:genetics* / Q000401:mortality; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D058534:Class I Phosphatidylinositol 3-Kinases; D018282:Cystadenocarcinoma, Mucinous / Q000235:genetics; D018284:Cystadenocarcinoma, Serous / Q000235:genetics; D004252:DNA Mutational Analysis; D004789:Enzyme Activation / Q000187:drug effects; D005091:Exons / Q000235:genetics; D005260:Female; D006801:Humans; D015993:Life Tables; D008875:Middle Aged; D020125:Mutation, Missense; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000401:mortality; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics*; D017354:Point Mutation; D017422:Sequence Analysis, DNA; D015996:Survival Rate
D019869:Phosphatidylinositol 3-Kinases; D058534:Class I Phosphatidylinositol 3-Kinases; C484760:PIK3CA protein, human