title: Improved lesion detection from spatially adaptive, minimally complex, Pixon reconstruction of planar scintigraphic images.
abstract: Pixon noise reduction was applied to 18 planar images, six each from 99mTc-methylene diphosphonate (99mTc-MDP), 67Ga citrate (67Ga), and (123)I-metaiodobenzylguanidine ((123)I-MIBG) studies. Pixon processing increased patient signal-to-noise ratio, 6.8-11.8 fold. Three specialists preferred processed images 44 of 54 times with good agreement (87%). Most (9/10, p<0.02) of the null and negative preferences were from (123)I-MIBG studies. Inter-rater association was shown for 1-4 scale rated artifact p<0.1, noise p<0.01 and lesion detection p<0.05. Pixon images had superior lesion detection ability, p<0.02, and noise levels, p<0.02 and no statistically significant change in artifacts.
authors.affiliation: Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ont., M5G 1X8, Canada. carl@candleview.com
authors.forename: Carl A
authors.initials: CA
authors.lastname: Wesolowski
authors.forename: Amos
authors.initials: A
authors.lastname: Yahil
authors.forename: Richard C
authors.initials: RC
authors.lastname: Puetter
authors.forename: Paul S
authors.initials: PS
authors.lastname: Babyn
authors.forename: David L
authors.initials: DL
authors.lastname: Gilday
authors.forename: Mustafa Z
authors.initials: MZ
authors.lastname: Khan
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015588:Observer Variation; D049268:Positron-Emission Tomography; D011877:Radionuclide Imaging / Q000379:methods*; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals