title: Epstein-Barr virus-associated lymphoproliferative disease after long-standing cyclosporine therapy for psoriasis: a case of spontaneous regression.
abstract: Posttransplant lymphoproliferative disorders are lymphoid proliferations or lymphomas, usually associated with Epstein-Barr virus infection, that develop as the consequence of immunodepression. These disorders usually affect patients receiving high doses of cyclosporine in the context of bone marrow or organ transplantations. Posttransplant lymphoproliferative disorders can regress when cyclosporine is discontinued. Such lymphoproliferations rarely occur for patients receiving low-dose cyclosporine treatments for autoimmune disorders. In the following report, we describe a patient with psoriasis vulgaris treated with long-term low-dose cyclosporine who developed an acute Epstein-Barr virus-associated clonal lymphoproliferative disorder associated with hemophagocytic syndrome. This lymphoproliferative disorder resembling classic posttransplant lymphoproliferative disorder regressed when cyclosporine was discontinued.
authors.affiliation: Department of Internal Medicine, Hôpital Bichat, Paris, France. lelievre@im3.inserm.fr
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Lelièvre
authors.forename: Karim
authors.initials: K
authors.lastname: Sacre
authors.forename: Homa
authors.initials: H
authors.lastname: Adle-Biassette
authors.forename: Valérie
authors.initials: V
authors.lastname: Molinier-Frenkel
authors.forename: Philippe
authors.initials: P
authors.lastname: Gaulard
authors.forename: Thomas
authors.initials: T
authors.lastname: Papo
mesh_terms: D001402:B-Lymphocytes; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D020031:Epstein-Barr Virus Infections / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000139:chemically induced* / Q000503:physiopathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012075:Remission, Spontaneous; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine