A glucosamine-dipicolylamine conjugate of 99mTc(I) and 186Re(I) for use in imaging and therapy.
The synthesis and metal complexation of a glucosamine-appended 2,2'-dipicolylamine ligand to the tricarbonyls of 99mTc and 186Re is described; the ligand was found to bind in a tridentate fashion with the glucosamine function remaining pendant, and the 99mTc complex was found to exhibit exceptional stability towards in vitro ligand exchange experiments.
Storr
Tim
T
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 2A3, Canada.
Fisher
Cara L
CL
Mikata
Yuji
Y
Yano
Shigenobu
S
Adam
Michael J
MJ
Orvig
Chris
C
D000588:Amines / Q000737:chemistry*; D005944:Glucosamine / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D015609:Organotechnetium Compounds / Q000737:chemistry*; D010848:Picolinic Acids / Q000737:chemistry*; D016719:Radioimmunodetection; D011868:Radioisotopes; D012211:Rhenium / Q000737:chemistry*
C501847:2,2'-dipicolylamine; D000588:Amines; D008024:Ligands; D015609:Organotechnetium Compounds; D010848:Picolinic Acids; D011868:Radioisotopes; D012211:Rhenium; D005944:Glucosamine