Stabilization of bimanual coordination due to active interhemispheric inhibition: a dynamical account.
Based on recent brain-imaging data and congruent theoretical insights, a dynamical model is derived to account for the patterns of brain activity observed during stable performance of bimanual multifrequency patterns, as well as during behavioral instabilities in the form of phase transitions between such patterns. The model incorporates four dynamical processes, defined over both motor and premotor cortices, which are coupled through inhibitory and excitatory inter- and intrahemispheric connections. In particular, the model underscores the crucial role of interhemispheric inhibition in reducing the interference between disparate frequencies during stable performance, as well as the failure of this reduction during behavioral transitions. As an aside, the model also accounts for in- and antiphase preferences during isofrequency movements. The viability of the proposed model is illustrated by magnetoencephalographic signals that were recorded from an experienced subject performing a polyrhythmic tapping task that was designed to induce transitions between multifrequency patterns. Consistent with the models dynamics, contra- and ipsilateral cortical areas of activation were frequency- and phase-locked, while their activation strength changed markedly in the vicinity of transitions in coordination.
Daffertshofer
A
A
Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands. marlow@fbw.vu.nl
Peper
C Lieke E
CL
Beek
Peter J
PJ
D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D003344:Cortical Synchronization; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007266:Inhibition, Psychological; D015225:Magnetoencephalography / Q000379:methods; D008959:Models, Neurological; D017711:Nonlinear Dynamics; D011597:Psychomotor Performance / Q000502:physiology*; D013997:Time Factors