title: [Combined use of local anesthetic with clonidine in cases of tooth extraction].
abstract: The technique of local anesthesia by lidocain in combination with clonidine (clofelinum) as vasoconstrictor in the dose of 1 microg/kg was compared with local anesthesia by novocain in combination with adrenaline (1:200 000) or by lidocain without vasoconstrictor or by articain in combination with adrenaline (0.012 mg/ml). Lidocain use led to expressed tachycardia and considerable increase of cardiac oufput in moderate hypertension reactions. Adrenaline addition in anesthetic solution increases general peripheral resistance and all parameters of arterial pressure with simultaneous rise of heart contractions. Adrenaline substitution as local vasoconstrictor for clofelinum decreases sympathetic tension during operation, prevents hypertensive reactions as the result of general peripheral resistance decrease, stabilizes heart rhythm and basic indices of central hemodynamics, that testifies to its (technique) adequacy.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Mishunin
authors.forename: I F
authors.initials: IF
authors.lastname: Ostreĭkov
authors.forename: N A
authors.initials: NA
authors.lastname: Nazarov
authors.forename: L E
authors.initials: LE
authors.lastname: Bogdanova
authors.forename: O V
authors.initials: OV
authors.lastname: Voĭkovskiĭ
authors.forename: I N
authors.initials: IN
authors.lastname: Morozov
authors.forename: I A
authors.initials: IA
authors.lastname: Bannova
authors.forename: A V
authors.initials: AV
authors.lastname: Nikiforov
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage*; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002319:Cardiovascular System / Q000187:drug effects; D003000:Clonidine; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007267:Injections; D008012:Lidocaine / Q000008:administration & dosage*; D014080:Tooth Exfoliation; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology
chemical_list: D000316:Adrenergic alpha-Agonists; D000779:Anesthetics, Local; D004338:Drug Combinations; D008012:Lidocaine; D003000:Clonidine