title: [Study on anti-bacterium activity of ginkgolic acids and their momomers].
abstract: OBJECTIVE
  Ginkgolic acids and their three monomers were separated from ginkgo sarcotestas. The anti-bacterium activity of ginkgolic acids were tested. The relation between the anti-bacterium activity and side chain of ginkgolic acid were studied.
  
  
  METHODS
  The MIC of ginkgolic acids and their three monomers and salicylic acid were tested.
  
  
  RESULTS
  Ginkgolic acid has strong inhibitive effect on G+-bacterium. Salicylic acid has no side chain, so no anti-bacterial activity. When the length of gingkolic acid side chain is C13:0, it has the strongest anti-bacterial activity in three monomers.
  
  
  CONCLUSIONS
  The side chain of ginkgolic acid is the key functional group that possessed anti-bacterial activity. The length of Ginkgolic acid was the main effective factor of anti-bacterial activity.
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013. zjyxm2003@hotmail.com
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Qian
authors.forename: Jimin
authors.initials: J
authors.lastname: Xie
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D020441:Ginkgo biloba / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011425:Propionibacterium acnes / Q000187:drug effects*; D012459:Salicylates / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D012459:Salicylates; C112485:ginkgolic acid