title: Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein.
abstract: Proteins like Raf kinase inhibitory protein (RKIP) that serve as modulators of signaling pathways, either by promoting or inhibiting the formation of productive signaling complexes through protein-protein interactions, have been demonstrated to play an increasingly important role in a number of cell types and organisms. These proteins have been implicated in development as well as the progression of cancer. RKIP is a particularly interesting regulator, as it is a highly conserved, ubiquitously expressed protein that has been shown to play a role in growth and differentiation in a number of organisms and can regulate multiple signaling pathways. RKIP is also the first MAP kinase signaling modulator to be identified as playing a role in cancer metastasis, and identification of the mechanism by which it regulates Raf-1 activation provides new targets for therapeutic intervention.
authors.affiliation: Ben May Institute for Cancer Research, University of Chicago, 5841 S. Maryland Avenue., Chicago, IL 60637, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Trakul
authors.forename: Marsha R
authors.initials: MR
authors.lastname: Rosner
mesh_terms: D000818:Animals; D002417:Cattle; D002454:Cell Differentiation; D049109:Cell Proliferation; D018450:Disease Progression; D006801:Humans; D020935:MAP Kinase Signaling System; D051379:Mice; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction; D048490:raf Kinases / Q000378:metabolism*
chemical_list: D048490:raf Kinases; D011493:Protein Kinase C