Electrophilic properties of nitroheterocyclic compounds. Potential hypoxic cells radiosensitizers.
Investigation of the reduction potential and calculation of the partition coefficient n-octanol/water allow the assessment of the potential suitability of nitropirydine N-oxide compounds in radiotherapy of cancer. Experiments were carried out using cyclic voltammetry with HMDE as working electrode. The electrode reduction of the investigated compounds is quite irreversible and strongly dependent on pH.
Zieba-Mizgała
Anna
A
Faculty of Chemistry, University of Wrocław, 14 F. Joliot-Curie Str., 50-383 Wrocław, Poland. zieba@wchuwr.chem.uni.wroc.pl
Puszko
Aniela
A
Regiec
Andrzej
A
Kuduk-Jaworska
Janina
J
D003497:Cyclic N-Oxides / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D004566:Electrodes; D000860:Hypoxia / Q000473:pathology / Q000532:radiotherapy*; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy; D010084:Oxidation-Reduction; D011838:Radiation-Sensitizing Agents / Q000737:chemistry*; D055672:Static Electricity
D003497:Cyclic N-Oxides; D011838:Radiation-Sensitizing Agents