title: Guideline-based modeling of therapeutic strategies in the special case of chronic diseases.
abstract: Despite the availability of evidence-based clinical practice guidelines in most countries, patients with chronic diseases are still generally inadequately managed. One difficulty lies in the optimal synchronization of a patient with the guideline therapeutic strategy, especially when the history of her past treatments does not follow the recommended sequence of therapies. We propose a formal model to represent guideline-based therapeutic strategies as a two-level decision tree. The clinical level is used to identify a patient-specific clinical situation, on the basis of key elements of clinical examination (complication of hypertension, associated diseases). The therapeutic level is derived from the formalization of guideline-based strategies first represented as bidimensional matrices structured in lines of therapy and levels of therapeutic intention. A revised version based on the ordering of levels of therapeutic combination is then developed. The aim is to dynamically provide the best next step of treatment from the patient's therapeutic-history-based customization of the general therapeutic sequence established in the guideline for the corresponding clinical situation. A preliminary in vitro evaluation of the system on actual clinical cases showed a positive impact on physician compliance with a significant increase from 16 to 57%.
authors.affiliation: STIM/DPA/DSI, Assistance Publique-Hopitaux de Paris, Paris, France. brigitte.seroussi@sap.aphp.fr
authors.forename: B
authors.initials: B
authors.lastname: Seroussi
authors.forename: J
authors.initials: J
authors.lastname: Bouaud
authors.forename: G
authors.initials: G
authors.lastname: Chatellier
mesh_terms: D002170:Canada; D002908:Chronic Disease; D020000:Decision Support Systems, Clinical; D006801:Humans; D006973:Hypertension / Q000628:therapy; D017410:Practice Guidelines as Topic