title: Rigid internal fixation with titanium versus bioresorbable miniplates in the repair of mandibular fractures in rabbits.
abstract: The purpose of this study was to compare by qualitative histology the efficacy of rigid internal fixation with titanium system and the Lacto Sorb system in mandibular fractures in rabbits. Thirty male adult rabbits Oryctolagus cuniculus were used. Unilateral mandibular osteotomies were performed between the canine and first premolar. The animals were divided into two groups: for Group I-rigid internal fixation was performed with titanium system 1.5 mm (Synthes, Oberdorf, Switzerland), with two screws of 6 mm (bicortical) on each side of the osteotomy. For Group II-rigid internal fixation was performed with PLLA/PGA system 1.5 mm (Lacto Sorb, WLorenz, Jacksonville, FL, USA). The histological analysis evaluated the presence of inflammatory reaction, degree of bone healing and degree of resorption of the Lacto Sorb screws. The results of both fixation systems were similar, only with a small difference after 15 and 30 days. In Group I a faster bony healing was noted. But after 60 days, bony healing was similar in both groups. It is concluded that both PLLA/PGA and titanium plates and screws provide sufficient strength to permit mandibular bone healing. The resorption process of PLLA/PGA osteosynthesis material did not cause acute or chronic inflammatory reaction or foreign body reaction during the studied period.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Dental School at Araraquara, Sao Paulo State University, Araraquara, Brazil. hochuli@foar.unesp.br
authors.forename: E
authors.initials: E
authors.lastname: Hochuli-Vieira
authors.forename: M A
authors.initials: MA
authors.lastname: Cabrini Gabrielli
authors.forename: V A
authors.initials: VA
authors.lastname: Pereira-Filho
authors.forename: M F R
authors.initials: MF
authors.lastname: Gabrielli
authors.forename: J G
authors.initials: JG
authors.lastname: Padilha
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001860:Bone Plates; D001863:Bone Screws; D004867:Equipment Design; D005593:Fracture Fixation, Internal / Q000295:instrumentation*; D015726:Giant Cells / Q000473:pathology; D019344:Lactic Acid / Q000737:chemistry; D008297:Male; D008337:Mandibular Fractures / Q000473:pathology / Q000601:surgery*; D010006:Osteoblasts / Q000473:pathology; D010011:Osteocytes / Q000473:pathology; D010012:Osteogenesis / Q000502:physiology; D010027:Osteotomy; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D011817:Rabbits; D013997:Time Factors; D014025:Titanium / Q000737:chemistry; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D014025:Titanium