title: A new route to trihydroxamate-containing artificial siderophores and synthesis of a new fluorescent probe.
abstract: A fluorescent labelled artificial siderophore 1 was synthesized by coupling a 7-nitrobenz-2-oxa-1,3-diazole (NBD) derivative to the terminal amino group of a new trihydroxamate-containing amine 2, a ferrichrome-type siderophore that was obtained from tris(hydroxymethyl)aminomethane. Compound 1 was shown to be a suitable tool for experiments on siderophore transport and uptake processes in various organisms cells and particularly in Candida albicans cells.
authors.affiliation: Chimie, Ingénierie Moléculaire et Matériaux d'Angers, UMR 6200 du CNRS, 2 Boulevard Lavoisier, 49045 Angers Cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Ouchetto
authors.forename: M
authors.initials: M
authors.lastname: Dias
authors.forename: R
authors.initials: R
authors.lastname: Mornet
authors.forename: E
authors.initials: E
authors.lastname: Lesuisse
authors.forename: J-M
authors.initials: JM
authors.lastname: Camadro
mesh_terms: D005291:Ferrichrome / Q000138:chemical synthesis* / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000737:chemistry*; D007502:Iron Chelating Agents / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D017262:Siderophores / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D006877:Hydroxamic Acids; D007502:Iron Chelating Agents; D017262:Siderophores; D005291:Ferrichrome