title: Oesophageal strictures in cats associated with doxycycline therapy.
abstract: Four cases of oesophageal stricture subsequent to doxycycline administration are reported. All cases were young to middle age (median age 3 years; range 1-7 years), and either domestic shorthair or domestic longhair breed. In all cases the predominant clinical sign was regurgitation, which developed at variable times after doxycycline administration. In all cases the reason for doxycycline use was treatment or prophylaxis of suspected infections (Mycoplasma haemofelis, Chlamydophila felis or Bordetella bronchiseptica), and the duration of therapy was variable. In one case the stricture was definitively diagnosed at post mortem examination, in the three other cases, definitive diagnosis was by endoscopy. Balloon dilation was successful in the three cases that were treated. This is the largest case series, to date, of oesophageal disease in cats associated with doxycycline administration. Caution should be exercised when administering oral medication to cats, especially doxycycline, and should be accompanied either by a water or food swallow.
authors.affiliation: Department of Clinical Veterinary Science, University of Bristol, Langford House, Bristol BS40 5DU, UK. ajgerman@liv.ac.uk
authors.forename: Alexander James
authors.initials: AJ
authors.lastname: German
authors.forename: Martha Jane
authors.initials: MJ
authors.lastname: Cannon
authors.forename: Charlotte
authors.initials: C
authors.lastname: Dye
authors.forename: Malcolm John
authors.initials: MJ
authors.lastname: Booth
authors.forename: Geoffrey Robert
authors.initials: GR
authors.lastname: Pearson
authors.forename: Caroline Anne
authors.initials: CA
authors.lastname: Reay
authors.forename: Timothy John
authors.initials: TJ
authors.lastname: Gruffydd-Jones
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D001885:Bordetella Infections / Q000662:veterinary; D002371:Cat Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000382:microbiology; D002404:Catheterization / Q000379:methods / Q000662:veterinary; D002415:Cats; D023521:Chlamydophila Infections / Q000662:veterinary; D004318:Doxycycline / Q000009:adverse effects* / Q000627:therapeutic use; D004724:Endoscopy; D004940:Esophageal Stenosis / Q000139:chemically induced / Q000662:veterinary*; D005260:Female; D008297:Male; D009175:Mycoplasma Infections / Q000662:veterinary
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline