title: Glucose tolerance in pregnancy in South India: relationships to neonatal anthropometry.
abstract: BACKGROUND
  The incidence of type 2 diabetes is increasing worldwide, most rapidly in developing countries such as India. Exposure as a fetus to maternal gestational diabetes is thought to be a risk factor for developing the disease. This study was set up to determine the incidence of gestational diabetes mellitus in one urban maternity unit in South India and to examine its effect on the offspring's neonatal anthropometry, childhood growth, and glucose/insulin metabolism. This paper reports neonatal outcomes.
  
  
  METHODS
  Seven hundred and eighty five women were recruited consecutively from the antenatal clinic of the Holdsworth Memorial Hospital, Mysore and underwent a 100 g, 3-hr oral glucose tolerance test at 30 +/- 2 weeks gestation. Gestational diabetes was defined using Carpenter and Coustan criteria. The babies were measured in detail at birth.
  
  
  RESULTS
  Mean maternal age and body mass index were 23.6 years and 23.1 kg/m(2). The incidence of gestational diabetes was 6.2%. Mothers with gestational diabetes had babies that were heavier (3339 g compared with 2956 g for non-diabetic mothers) and larger in measurements of fat, muscle, and skeleton. Even in non-diabetic pregnancies, neonatal weight, head circumference, and ponderal index were positively related to maternal fasting glucose concentrations (P < or = 0.05 for all).
  
  
  CONCLUSIONS
  The incidence of gestational diabetes was high in this unselected sample of mothers booking into one urban Indian maternity unit. Community-based studies are required to confirm this. The effect of maternal glucose concentrations on neonatal anthropometry is continuous and extends into the "normal" glycemic range.
authors.affiliation: MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, England, UK.
authors.forename: Jacqueline C
authors.initials: JC
authors.lastname: Hill
authors.forename: Ghattu Vedamurthy
authors.initials: GV
authors.lastname: Krishnaveni
authors.forename: I
authors.initials: I
authors.lastname: Annamma
authors.forename: Samantha D
authors.initials: SD
authors.lastname: Leary
authors.forename: Caroline H D
authors.initials: CH
authors.lastname: Fall
mesh_terms: D000886:Anthropometry; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005320:Fetal Macrosomia / Q000175:diagnosis / Q000453:epidemiology*; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D011295:Prenatal Care; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D012959:Socioeconomic Factors
chemical_list: D001786:Blood Glucose