title: Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with pathogenic congeners.
abstract: Vibrio fischeri belongs to the Vibrionaceae, a large family of marine gamma-proteobacteria that includes several dozen species known to engage in a diversity of beneficial or pathogenic interactions with animal tissue. Among the small number of pathogenic Vibrio species that cause human diseases are Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus, the only members of the Vibrionaceae that have had their genome sequences reported. Nonpathogenic members of the genus Vibrio, including a number of beneficial symbionts, make up the majority of the Vibrionaceae, but none of these species has been similarly examined. Here we report the genome sequence of V. fischeri ES114, which enters into a mutualistic symbiosis in the light organ of the bobtail squid, Euprymna scolopes. Analysis of this sequence has revealed surprising parallels with V. cholerae and other pathogens.
authors.affiliation: Pacific Biomedical Research Center, Kewalo Marine Laboratory, and W. M. Keck Microbial Communities and Cell Signaling Program, University of Hawaii, Honolulu, HI 96813, USA. egruby@wisc.edu
authors.forename: E G
authors.initials: EG
authors.lastname: Ruby
authors.forename: M
authors.initials: M
authors.lastname: Urbanowski
authors.forename: J
authors.initials: J
authors.lastname: Campbell
authors.forename: A
authors.initials: A
authors.lastname: Dunn
authors.forename: M
authors.initials: M
authors.lastname: Faini
authors.forename: R
authors.initials: R
authors.lastname: Gunsalus
authors.forename: P
authors.initials: P
authors.lastname: Lostroh
authors.forename: C
authors.initials: C
authors.lastname: Lupp
authors.forename: J
authors.initials: J
authors.lastname: McCann
authors.forename: D
authors.initials: D
authors.lastname: Millikan
authors.forename: A
authors.initials: A
authors.lastname: Schaefer
authors.forename: E
authors.initials: E
authors.lastname: Stabb
authors.forename: A
authors.initials: A
authors.lastname: Stevens
authors.forename: K
authors.initials: K
authors.lastname: Visick
authors.forename: C
authors.initials: C
authors.lastname: Whistler
authors.forename: E P
authors.initials: EP
authors.lastname: Greenberg
mesh_terms: D048908:Aliivibrio fischeri / Q000235:genetics* / Q000472:pathogenicity; D001427:Bacterial Toxins / Q000235:genetics; D001482:Base Composition; D001483:Base Sequence; D010861:Fimbriae, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D005810:Multigene Family; D016366:Open Reading Frames; D010957:Plasmids; D013559:Symbiosis
chemical_list: D001427:Bacterial Toxins