title: Oxidation of Zn(N2S2) complexes to disulfonates: relevance to zinc-finger oxidation under oxidative stress.
abstract: A series of Zn(N2S2) complexes has been prepared, and characterized. They have different nitrogen donors such as, either two amidates, two amines, two imines or one amidate and one imine. A bis-amidato dithiolato complex has been structurally characterized by single crystal X-ray diffraction analysis, and exhibits a distorted tetrahedral structure. Oxidation of all these complexes with dioxirane or anhydrous H2O2 results in the formation of a unique product, the disulfonate species. Most often, zinc was found to be released during the course of the oxidation. The bis-imine/bis-sulfonate species is the only one to retain zinc. This complex was crystallized with two pyridine molecules. Its crystal structure reveals a distorted octahedral environment around the zinc cation.
authors.affiliation: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université René Descartes, 45 rue des Sts Pères, 75270 Paris Cedex 06, France.
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Alves de Sousa
authors.forename: Erwan
authors.initials: E
authors.lastname: Galardon
authors.forename: Mathieu
authors.initials: M
authors.lastname: Rat
authors.forename: Michel
authors.initials: M
authors.lastname: Giorgi
authors.forename: Isabelle
authors.initials: I
authors.lastname: Artaud