Comparison of the effect of Sporobolus virginicus and Rhodes (Chloris gayana) hay diets on the absorption pattern of phenylbutazone in the camel (Camelus dromedarius).
The effect of feeding Sporobolus and Rhodes hay on phenylbutazone (4 g) relative absorption was examined in six camels using a two-period, two-sequence, two-treatment crossover design. Serum concentration of the drug was measured by high performance liquid chromatography. The measured values (means+/-SD) for Rhodes and Sporobolus hay, respectively, were Cmax 35.59+/-22.36 and 36.55+/-18.99 microg/mL, Tmax 26+/-2.53 and 26.3+/-1.97 h and AUC0-72 h 1552+/-872.6 and 1621+/-903.6 microg h/mL. Broad plateau concentrations of phenylbutazone in serum were observed between 12 and 36 h. There was no significant difference in any parameter between the two feeding regimens. Multiple peaks in serum concentration-time curve were observed, regardless of the type of grass available to and the animals prior to drug administration. It was concluded that the phasic absorption of phenylbutazone was a particular feature of hay feeding in camels, and the Sporobolus hay can be fed to camels without any effect on the rate and extent of phenylbutazone absorption compared to Rhodes grass hay.
Abdel Hadi
A A
AA
Camel Racing Laboratory, Forensic Science Laboratory, P.O. Box 253, Abu Dhabi, United Arab Emirates. aahadi@emirates.net.ae
Wasfi
I A
IA
Elghazali
M
M
Almahrami
A M
AM
Barezaiq
I M
IM
Alkatheeri
N A
NA
Alhadrami
G A
GA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002162:Camelus / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D018592:Cross-Over Studies; D018565:Food-Drug Interactions; D007408:Intestinal Absorption; D010653:Phenylbutazone / Q000097:blood / Q000493:pharmacokinetics*; D006109:Poaceae
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010653:Phenylbutazone