[Studies on effects of aluminum compounds on aluminum contents in serum and brain of mice with high performance capillary electrophoresis].
OBJECTIVE
To study the effects of alum, aluminum chloride and aluminum hydroxide on aluminum contents in serum and brain of mice with high performance capillary.


METHODS
60 days after the mice were given daily alum, aluminum chloride and aluminum hydroxide with the same aluminum content of 14.25, 57 mg x kg(-1) x d(-1), respectively, the aluminum content in serum and brain of mice were determined with high performance capillary chromatography.


RESULTS
The average recoveries of serum aluminum determination was 96.5%-103%. The average recoveries of brain aluminum assay was 92.2%-105.3%. Except control group, serum aluminum increased obviously. Brain aluminum increased in all the large doses groups. 2 weeks after the mice were stopped being given these drugs, serum and brain aluminum recovered to normal level, except aluminum chloride large doses group.


CONCLUSIONS
The metabolism and excretion mechanism of aluminum in mice depends on the chemical states of the aluminum compound.
Wu
Ying-hong
YH
Institute of Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
Zhou
Zhong-ming
ZM
Wang
Yan-li
YL
D000284:Administration, Oral; D000534:Alum Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000535:Aluminum / Q000097:blood* / Q000378:metabolism; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002712:Chlorides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019075:Electrophoresis, Capillary / Q000379:methods; D008297:Male; D051379:Mice
D000534:Alum Compounds; D017607:Aluminum Compounds; D002712:Chlorides; C041524:aluminum sulfate; D000077410:Aluminum Chloride; D000536:Aluminum Hydroxide; D000535:Aluminum