Aspochalamins A-D and aspochalasin Z produced by the endosymbiotic Fungus aspergillus niveus LU 9575. I. Taxonomy, fermentation, isolation and biological activities.
Aspochalamins A-D, a family of new cytochalasan antibiotics have been isolated from Aspergillus niveus, an endosymbiotic fungus isolated from the gut of a woodlouse belonging to the family Trichoniscidae. Besides aspochalamins, aspochalasin Z, a new member of the aspochalasin family, as well as the known mycotoxins aspochalasin D and citreoviridins A/C and B were isolated from the mycelium. Aspochalamins showed cytostatic effects towards various tumor cell lines and a weak antibacterial activity against Gram-positive bacteria.
Gebhardt
Klaus
K
Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
Schimana
Judith
J
Höltzel
Alexandra
A
Dettner
Konrad
K
Draeger
Siegfried
S
Beil
Winfried
W
Rheinheimer
Joachim
J
Fiedler
Hans-Peter
HP
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D001230:Aspergillus / Q000145:classification / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003572:Cytochalasins / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003572:Cytochalasins; C497074:aspochalamin A; C497077:aspochalamin B; C497076:aspochalamin C; C497075:aspochalamin D