[Corneal precipitation of fluoroquinolones with magnesium].
Infrared spectrophotometric analysis (FTIR) was performed on a crystalline deposit developed in a corneal ulcer by an old woman who received ciprofloxacine ophthalmic drops. We collected the data of the literature on the subject. After in vitro crystallization experiments, we conclude that ciprofloxacin and norfloxacin corneal precipitates occur at physiological lachrymal pH with magnesium.
Parent
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Service de biochimie, Centre hospitalier Pasteur, Colmar. xavier.parent@ch-colmar.rss.fr
Marchal
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Patillon
J C
JC
D000368:Aged; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000302:isolation & purification* / Q000627:therapeutic use*; D003320:Corneal Ulcer / Q000473:pathology* / Q000503:physiopathology*; D003460:Crystallization; D005260:Female; D024841:Fluoroquinolones / Q000302:isolation & purification / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000494:pharmacology; D009643:Norfloxacin / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D009883:Ophthalmic Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013666:Tears / Q000187:drug effects / Q000502:physiology
D024841:Fluoroquinolones; D009883:Ophthalmic Solutions; D002939:Ciprofloxacin; D008274:Magnesium; D009643:Norfloxacin