title: Rapid recurrence of nonalcoholic fatty liver disease after transplantation in a child with hypopituitarism and hepatopulmonary syndrome.
abstract: Nonalcoholic fatty liver disease (NAFLD) has been reported in adults with hypothalamic or pituitary dysfunction, and some have progressed to end stage liver disease requiring transplantation. We report a teenager who initially presented with hypoxia due to intrapulmonary shunting, found to have NAFLD and cirrhosis associated with a hypothalamic tumor and panhypopituitarism. The NAFLD recurred very quickly after a successful liver transplant. Hepatopulmonary syndrome may be more common in cirrhosis associated with pituitary dysfunction than in other types of cirrhosis.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. maureen.jonas@childrens.harvard.edu
authors.forename: Maureen M
authors.initials: MM
authors.lastname: Jonas
authors.forename: Laura E
authors.initials: LE
authors.lastname: Krawczuk
authors.forename: Heung Bae
authors.initials: HB
authors.lastname: Kim
authors.forename: Craig
authors.initials: C
authors.lastname: Lillehei
authors.forename: Antonio
authors.initials: A
authors.lastname: Perez-Atayde
mesh_terms: D000293:Adolescent; D005234:Fatty Liver / Q000150:complications* / Q000473:pathology*; D020065:Hepatopulmonary Syndrome / Q000150:complications*; D006801:Humans; D007018:Hypopituitarism / Q000150:complications*; D016031:Liver Transplantation; D008297:Male; D011183:Postoperative Complications / Q000473:pathology; D012008:Recurrence