Fluorescence studies of the intra-cellular distribution of zinc bis(thiosemicarbazone) complexes in human cancer cells.
The uptake of zinc bis(thiosemicarbazone) complexes in human cancer cells has been studied by fluorescence microscopy and the cellular distribution established, including the degree of uptake in the nucleus.
Cowley
Andrew R
AR
Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UKOX1 3TA.
Davis
Jason
J
Dilworth
Jonathan R
JR
Donnelly
Paul S
PS
Dobson
Rachel
R
Nightingale
Adrian
A
Peach
Josephine M
JM
Shore
Ben
B
Kerr
David
D
Seymour
Len
L
D045744:Cell Line, Tumor; D006801:Humans; D008856:Microscopy, Fluorescence / Q000379:methods; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D015032:Zinc / Q000737:chemistry*
D009942:Organometallic Compounds; D013882:Thiosemicarbazones; D015032:Zinc