Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy.
Anorectal malignant melanoma is a rare tumor and there is no consensus on whether aggressive or local management is more appropriate. Local sphincter-saving excision has been shown to have a higher recurrence rate than abdominoperineal resection, although there is no long-term survival difference between the two approaches. Therefore, new adjuvant treatment strategies to permit local sphincter-saving excisions are warranted. In our case, a large anorectal malignant melanoma was successfully treated preoperatively by electrochemotherapy with cisplatin that, by reducing the tumor size, enabled sphincter-saving local excision. Brachytherapy was postoperatively delivered to the excision site. Fourteen months after the beginning of treatment, the patient is without signs of local recurrence and is continent.
Snoj
Marko
M
Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Rudolf
Zvonimir
Z
Cemazar
Maja
M
Jancar
Boris
B
Sersa
Gregor
G
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000601:surgery; D001918:Brachytherapy; D002945:Cisplatin / Q000008:administration & dosage*; D004358:Drug Therapy / Q000379:methods; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D002945:Cisplatin