[Correction by 2-ethyl-6-methyl-3-hydroxypyridine succinate of the hepatotoxyc, caused at rats introduction tuberculostatics].
Administration of toxic doses of means specific tuberculostatics chemotherapy to rats caused development of medicinal damages of liver, kidneys, and pancreas. Use of 2-ethyl-6-methyl-hydroxypyridine succinate (SEMOP) and S-adenosyl-L-methionine reduced manifestations of pathological effects of tuberculostatics an organism of laboratory animals. There was clear dose-dependence of SEMOP effects. The highest cytoprotective effect was observed at the SEMOP dose of 50 mg/kg. Antioxidant properties of SEMOP determined it membrane protective effects.
Katikova
O Iu
OIu
Ruzov
V I
VI
Smirnov
L D
LD
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D000995:Antitubercular Agents / Q000633:toxicity*; D019610:Cytoprotection / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006505:Hepatitis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D010847:Picolines / Q000008:administration & dosage*; D051381:Rats; D012436:S-Adenosylmethionine / Q000008:administration & dosage
D000975:Antioxidants; D000995:Antitubercular Agents; D010847:Picolines; C070020:emoxypine succinate; D012436:S-Adenosylmethionine