title: Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia.
abstract: The function of microglia in the brain parenchyma is not fully understood. Occlusion of the middle cerebral artery (MCA) and reperfusion caused behavioral dysfunction with massive neuronal loss in the rat cerebral cortex and striatum. When exogenous microglia were microinjected into the intracerebroventricle (i.c.v.) during MCA occlusion, focal ischemia-induced behavioral dysfunction was significantly inhibited. At that time, many microglia migrated into the ischemic lesion, and microglia-derived neuron-like cells were barely detectable. These results suggest that exogenous microglia protect against focal ischemia-induced neurodegeneration and improve behavioral dysfunction.
authors.affiliation: Department of Neurobiology, Kyoto Pharmaceutical University, Japan. yo-kita@mb-kyoto-phu.ac.jp
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Daijiro
authors.initials: D
authors.lastname: Yanagisawa
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Inden
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Takata
authors.forename: Daiju
authors.initials: D
authors.lastname: Tsuchiya
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kawasaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Shun
authors.initials: S
authors.lastname: Shimohama
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology* / Q000628:therapy*; D007276:Injections, Intraventricular; D008297:Male; D017628:Microglia / Q000166:cytology / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000502:physiology*; D045442:Rotarod Performance Test / Q000379:methods; D012399:Rotation