Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma.
BACKGROUND
Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma (HCC-CC) have not been established.


METHODS
Data of patients who underwent surgical resection for HCC-CC were compared with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CC) patients.


RESULTS
The prevalence of hepatitis B positivity (54.0%) and that of cirrhosis (54.2%) in the HCC-CC group were of intermediate tendency between the HCC group and the CC group. The HCC-CC group presented with a higher prevalence of multiplicity and microvascular emboli and portal vein or hepatic vein invasion, but a lower prevalence of capsular formation compared with the other groups. One- and 3-year survival rates in the HCC-CC group (81.9% and 47.0%, respectively) were lower than those in the HCC group and higher than those in the CC group. The cumulative recurrence rates at 6 months and at 1 year in the HCC-CC group (25.0% and 33.3%, respectively) were higher than those in the HCC group and lower than those in the CC group.


CONCLUSIONS
The HCC-CC group has distinct clinicopathologic features compared with the HCC or CC groups. In addition, the HCC-CC group has a prognosis that is better than the CC group but worse than the HCC group.
Koh
Kwang Cheol
KC
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong 50, Kangnam-ku, Seoul, Korea 135-710.
Lee
Hyuk
H
Choi
Moon Seok
MS
Lee
Joon Hyoek
JH
Paik
Seung Woon
SW
Yoo
Byung Chul
BC
Rhee
Jong Chul
JC
Cho
Jae Won
JW
Park
Cheol Keun
CK
Kim
Hong Joo
HJ
D000328:Adult; D000368:Aged; D001653:Bile Ducts, Intrahepatic; D006528:Carcinoma, Hepatocellular / Q000401:mortality* / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000401:mortality* / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis