title: In vitro bioassay as a predictor of in vivo response.
abstract: BACKGROUND
  There is a substantial discrepancy between in vitro and in vivo experiments. The purpose of the present work was development of a theoretical framework to enable improved prediction of in vivo response from in vitro bioassay results.
  
  
  RESULTS
  For dose-response curve reaches a plateau in vitro we demonstrated that the in vivo response has only one maximum. For biphasic patterns of biological response in vitro both the bimodal and biphasic in vivo responses might be observed.
  
  
  CONCLUSIONS
  As the main result of this work we have demonstrated that in vivo responses might be predicted from dose-effect curves measured in vitro.
authors.affiliation: Department of Biochemistry, The University of Queensland, Brisbane, Qld 4072, Australia. barnard@biosci.uq.edu.au
authors.forename: Ross
authors.initials: R
authors.lastname: Barnard
authors.forename: Konstantin G
authors.initials: KG
authors.lastname: Gurevich
mesh_terms: D001681:Biological Assay / Q000379:methods*; D004305:Dose-Response Relationship, Drug