Antibody responses to Asian and American genotypes of dengue 2 virus in immunized mice.
The possibility of a correlation between dengue virus genotype groups and disease severity is currently under discussion. The objective of this investigation was to identify any immunogenic difference between the American and Asian dengue 2 virus genotypes through the study of antibody development (virus-binding immunoglobulin G and neutralizing antibodies) in mice. Differences in the neutralization pattern between the strains studied were observed, suggesting the presence of slight antigenic variations among them. The lack of recognition of one of the Asian genotype strains was remarkable.
Bernardo
Lidice
L
Virology Department, PAHO/WHO Collaborating Center for Viral Diseases, Pedro Kourí Tropical Medicine Institute, Autopista Novia del Mediodía, Km 6, Havana, Cuba.
Yndart
Adriana
A
Vázquez
Susana
S
Morier
Luis
L
Guzmán
María G
MG
D000569:Americas; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D001208:Asia; D003716:Dengue Virus / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D005814:Genes, Viral; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D051379:Mice; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral; C051821:E-glycoprotein, Dengue virus type 2; D007074:Immunoglobulin G; D014759:Viral Envelope Proteins