[Cerebral haemorrhage in patients treated with oral anticoagulation].
BACKGROUND
Intracranial haemorrhage (ICH) during dicumarinic treatment is a complication related to anticoagulation intensity with a high level of mortality. The aim of our study is to analize etiology, location and outcome of intracerebral haemorrhages related with anticoagulant therapy.


METHODS
Over 401 spontaneous intracranial haemorrhages consecutively admitted in the neurological ward, we analyzed the acenocumarol ICH by location, anticoagulation range and factors that conditioned the outcome.


RESULTS
We identified 26 patients, 6.5% of total ICH. Mean age was 75.2 +/- 7.9 years-old, over the rest of ICH. International Normalized Ratio (INR) was less than 2 in 10 patients, between 2 and 3 in six and greater than 3 in ten patients. 8 patients (31%) died, three of them had multiple ICH, but none of them had a INR greater than 2. Dicumarinic haemorrhages were of lobar location in 14 cases (three of them multiples) and deep in 12 cases.


CONCLUSIONS
In our study, dicumarinic ICH are responsible of 6.5% total intracranial haemorrhages and they are not in clear relation with excessive anticoagulation. Mortality is slightly greater than the other ICH. Relatively benignity of these patients, the age and lobar location suggest that the etiology of these haemorrhages can be related to a subjacent amyloid angiopathy.
Rodríguez-Campello
A
A
Unidad de Ictus, Hospital Universitario del Mar, Barcelona, España. 92269@imas.imim.es
Roquer-González
J
J
Gomis-Cortina
M
M
Munteis-Olivas
E
E
Ois-Santiago
A
A
Herraiz-Rocamora
J
J
D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects*; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D014859:Warfarin / Q000009:adverse effects*
D000925:Anticoagulants; D014859:Warfarin