[Studies on the renal toxicity caused by aristolochic acids (AAs) and Chinese herbs containing AAs].
The article summarized the general situation of the study on the renal toxicity caused by aristolochic acids (AAs) and Chinese herbs containing AAs. The renal lesion induced by AAs and Chinese herbs containing AAs locates mainly in renal tubules, and glomeruluses have no obvious histological change. The short term administration of large doses causes acute renal epithelia denaturalization and tubular necrosis, but the long-term administration may result in chronically progressive interstitial fibrosis of the kidney. Renal failure may occur following both acute and chronic renal lesion. The renal function should be strictly monitored while one is using the Chinese herbs containing AAs, and the dosage and duration for the treatment must be limited to prevent renal toxicity.
Liang
Ai-hua
AH
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing, 100700, China.
Ding
Xiao-shuang
XS
Liu
Bao-yan
BY
D000818:Animals; D029065:Aristolochiaceae / Q000737:chemistry; D034341:Aristolochic Acids / Q000009:adverse effects / Q000302:isolation & purification / Q000633:toxicity*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000302:isolation & purification / Q000633:toxicity*; D005355:Fibrosis; D006801:Humans; D007668:Kidney / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology*; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry; D051437:Renal Insufficiency / Q000139:chemically induced
D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal