title: Trisomy 11 in myeloid malignancies is associated with internal tandem duplication of both MLL and FLT3 genes.
abstract: In 20 patients with myeloid malignancies and isolated trisomy 11 an internal tandem duplication of the MLL and FLT3 genes was observed in 41% and 31% of the cases, respectively; 80% of the FLT3+ cases showed MLL self-fusion. Concomitant presence of MLL and FLT3 anomalies could be relevant in determining the poor outcome of patients with acute myeloid leukemia with trisomy 11.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Rege-Cambrin
authors.forename: Emilia
authors.initials: E
authors.lastname: Giugliano
authors.forename: Lucienne
authors.initials: L
authors.lastname: Michaux
authors.forename: Michel
authors.initials: M
authors.lastname: Stul
authors.forename: Patrizia
authors.initials: P
authors.lastname: Scaravaglio
authors.forename: Anna
authors.initials: A
authors.lastname: Serra
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Saglio
authors.forename: Anne
authors.initials: A
authors.lastname: Hagemeijer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002880:Chromosomes, Human, Pair 11; D020440:Gene Duplication; D015972:Gene Expression Regulation, Neoplastic; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008875:Middle Aged; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D013997:Time Factors; D014314:Trisomy; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3