CCR10 is expressed in cutaneous T-cell lymphoma.
Cutaneous T-cell lymphoma (CTCL) is characterized by recruitment of malignant T-cell clones into the skin. The mechanisms involved in tumor homing are still not fully elucidated, though chemokines and chemokine receptors have been suggested to play a role in the pathogenesis. Here, we demonstrate extensive expression of CCR10 in skin biopsies of patients with Sezary syndrome (SS, n = 3), mycosis fungoides (MF, n = 2) and unspecified CTCL (n = 3). In addition, we expand prior findings of CXCR3 expression in MF to other entities of CTCL. Expression of CCR5 was detected in 2 of the examined skin biopsies. The functionality of CCR10 and CXCR3 in SS was demonstrated using the SS T-cell line HUT78. Our data support a potential role of CXCR3 in CTCL and strongly suggest that CCR10 and its ligand CCL27 may contribute to the skin infiltration of malignant T-cells in this group of lymphoproliferative disorders.
Notohamiprodjo
Mike
M
Medical Poliklinik, Ludwig-Maximilians-University of Munich, Munich, Germany.
Segerer
Stephan
S
Huss
Ralf
R
Hildebrandt
Bernhard
B
Soler
Dulce
D
Djafarzadeh
Roghieh
R
Buck
Wiebke
W
Nelson
Peter J
PJ
von Luettichau
Irene
I
D000368:Aged; D000369:Aged, 80 and over; D045744:Cell Line, Tumor; D002465:Cell Movement; D017931:DNA Primers; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019169:Jurkat Cells; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics; D054447:Receptors, CCR10; D019707:Receptors, Chemokine / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology
C515706:CCR10 protein, human; D017931:DNA Primers; D012333:RNA, Messenger; D054447:Receptors, CCR10; D019707:Receptors, Chemokine