title: Protective efficacy of a recombinant plague vaccine when co-administered with another sub-unit or live attenuated vaccine.
abstract: Vaccines against bioterrorism agents offer the prospect of providing high levels of protection against airborne pathogens. However, the diversity of the bioterrorism threat means that it may be necessary to use several vaccines simultaneously. In this study we have investigated whether there are changes to the protective immune response to a recombinant sub-unit plague vaccine when it is co-administered with other sub-unit or live attenuated vaccines. Our results indicate that the co-administration of these vaccines did not influence the protection afforded by the plague vaccine. However, the co-administration of the plague sub-unit vaccine with a live vaccine resulted in markedly increased levels of IgG2a subclass antibodies, and markedly reduced levels of IgG1 subclass antibodies, to the plague sub-unit vaccine. This finding might have implications when considering the co-administration of other vaccine combinations.
authors.affiliation: Defence Science and Technology Laboratories, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. kfgriffin@dstl.gov.uk
authors.forename: Kate
authors.initials: K
authors.lastname: Griffin
authors.forename: Richard
authors.initials: R
authors.lastname: Bedford
authors.forename: Kate
authors.initials: K
authors.lastname: Townson
authors.forename: Robert
authors.initials: R
authors.lastname: Phillpotts
authors.forename: Simon
authors.initials: S
authors.lastname: Funnell
authors.forename: Margret
authors.initials: M
authors.lastname: Morton
authors.forename: Diane
authors.initials: D
authors.lastname: Williamson
authors.forename: Richard
authors.initials: R
authors.lastname: Titball
mesh_terms: D000818:Animals; D022122:Anthrax Vaccines / Q000008:administration & dosage; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology; D005260:Female; D007114:Immunization; D007074:Immunoglobulin G / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D010930:Plague / Q000276:immunology / Q000517:prevention & control; D010931:Plague Vaccine / Q000008:administration & dosage*; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D017778:Vaccines, Combined / Q000008:administration & dosage; D022223:Vaccines, Subunit / Q000008:administration & dosage; D014614:Vaccines, Synthetic / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage; D015010:Yersinia pestis / Q000276:immunology
chemical_list: D022122:Anthrax Vaccines; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D010931:Plague Vaccine; D014613:Vaccines, Attenuated; D017778:Vaccines, Combined; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic; D014765:Viral Vaccines