Echinosulfonic acid D: an ESI MSn evaluation of a new cytotoxic alkaloid from the New-Caledonian sponge Psammoclemma sp.
A new bromoindolesulfonic acid derivative, echinosulfonic acid D (1) was isolated from the New-Caledonian sponge Psammoclemma sp. in a minute quantity. The structure of the alkaloid was established by spectroscopic methods and, in particular, by ESI MSn experiments. Echinosulfonic acid D was cytotoxic to KB cells (IC50 2 microg/mL).
Rubnov
Shai
S
Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France.
Chevallier
Camille
C
Thoison
Odile
O
Debitus
Cécile
C
Laprevote
Olivier
O
Guénard
Daniel
D
Sévenet
Thierry
T
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007624:KB Cells / Q000187:drug effects; D008517:Phytotherapy; D011161:Porifera; D013451:Sulfonic Acids / Q000737:chemistry / Q000494:pharmacology*
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; D013451:Sulfonic Acids; C500035:echinosulfonic acid D