Synthetic fragments of antigenic lipophosphoglycans from Leishmania major and Leishmania mexicana and their use for characterisation of the Leishmania elongating alpha-D-mannopyranosylphosphate transferase.
The phosphorylated branched heptasaccharides 7 and 8, the octasaccharide 9 and the phosphorylated trisaccharides 5 and 6, which are fragments of the phosphoglycan portion of the surface lipophosphoglycans from Leishmania mexicana (5) or L. major (6-9), were synthesised by using the glycosyl hydrogenphosphonate method for the preparation of phosphodiester bridges. The compounds were tested as acceptor substrates/putative inhibitors for the Leishmania elongating alpha-D-mannosylphosphate transferase.
Higson
Adrian P
AP
Faculty of Life Sciences, Division of Biological Chemistry and Molecular Microbiology, University of Dundee (Carnelley Building), Dundee DD1 4HN, Scotland, UK.
Ross
Andrew J
AJ
Tsvetkov
Yury E
YE
Routier
Françoise H
FH
Sizova
Olga V
OV
Ferguson
Michael A J
MA
Nikolaev
Andrei V
AV
D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006028:Glycosphingolipids / Q000138:chemical synthesis* / Q000737:chemistry; D018320:Leishmania major / Q000737:chemistry*; D007894:Leishmania mexicana / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D014166:Transferases / Q000737:chemistry
D006028:Glycosphingolipids; C008290:lipophosphonoglycan; D014166:Transferases