title: The completed suicide as interplay of genes and environment.
abstract: The review will tackle the interplay of genetic and environmental risk factors behind the completed suicide. First, individual differences in suicidal behaviour in relation to heritability are presented followed by a brief discussion of genetic methods currently used to investigate candidate genes for the completed suicide. Further along the polygenetic, multi-factorial model of genetic proneness to suicidal behaviour is presented as interplay of genes and environment. Finally, the future implications in this quickly blossoming field of research are discussed.
authors.affiliation: Institute of Forensic Medicine, Medical Faculty, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.
authors.forename: J
authors.initials: J
authors.lastname: Balazic
authors.forename: A
authors.initials: A
authors.lastname: Marusic
mesh_terms: D004777:Environment; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D026901:Membrane Transport Proteins / Q000235:genetics; D008995:Monoamine Oxidase / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D044263:Receptors, Serotonin, 5-HT1 / Q000235:genetics; D044348:Receptors, Serotonin, 5-HT2 / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins; D013406:Suicide, Attempted; D014365:Tryptophan Hydroxylase / Q000235:genetics
chemical_list: D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D044263:Receptors, Serotonin, 5-HT1; D044348:Receptors, Serotonin, 5-HT2; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D014365:Tryptophan Hydroxylase; D008995:Monoamine Oxidase