title: Preparation and in vitro stability of (n,gamma) yttrium-90 hydroxyapatite.
abstract: Yttrium-90, produced by irradiating Y2O3 (15 mg) in the Pakistan Research Reactor (PARR-I) at a flux of approximately 1.5x10(14) neutrons/cm2/s, was used to prepare yttrium-90 hydroxyapatite particles for radiosynovectomy applications. The irradiated material was dissolved in concentrated hydrochloric acid, evaporated and taken up in distilled water. The 120 h irradiation resulted in the production of approximately 12GBq (324mCi) of 90Y at the end of irradiation (EOI) and the corresponding specific activity was approximately 1017GBq/g of yttrium. Hydroxyapatite (HA) particles were synthesized by an already reported method. Labeling of HA particles with 90Y was studied without a transchelating agent. Labeling yields of approximately 100% could be achieved with 40 mg of HA and 0.4 mg of 90Y. In vitro studies showed <2% loss of 90Y activity in normal saline and 1% human serum albumin solution over a period of 8 days. The high labeling yield, good stability and ease of preparation of the 90Y-HA particles indicate that these particles may find wide application in radiation synovectomy.
authors.affiliation: Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, Pakistan.
authors.forename: M
authors.initials: M
authors.lastname: Khalid
authors.forename: A
authors.initials: A
authors.lastname: Mushtaq
mesh_terms: D004355:Drug Stability; D017886:Durapatite / Q000138:chemical synthesis / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*; D015021:Yttrium Radioisotopes / Q000737:chemistry*
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; D017886:Durapatite