title: [The effect of lishi No.5 formula on the growth of human neuroblastoma cell line SY5Y].
abstract: OBJECTIVE
  To investigate the effect of Lishi No.5 formula on the growth of human neuroblastoma cell line SY5Y and find out the most effective drug dose.
  
  
  METHODS
  SY5Y cells were administrated by Lishi No.5 formula in different concentration. MTT metabolic rate was measured as the cell survival rate, then the dose-effect curve was made. LDH leakage rate, axonal length and area of cell body were used as the indicators.
  
  
  RESULTS
  In 0.125-0.75 g x L(-1) Lishi No. 5 formula could increase the cell survival rate and MTT metabolic rate, decreased LDH leakage rate, and enhance axonal length and area of cell body, compared with control group.
  
  
  CONCLUSIONS
  Lishi No.5 formula has the neurotrophic effect and can induce the survival of neuron.
authors.affiliation: Beijing Research Laboratory for Brain Aging, Beijing Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China.
authors.forename: Jing-yan
authors.initials: JY
authors.lastname: Zhang
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Zi-zhong
authors.initials: ZZ
authors.lastname: Li
authors.forename: Hao-ran
authors.initials: HR
authors.lastname: Cheng
authors.forename: Sheng-hai
authors.initials: SH
authors.lastname: Li
authors.forename: Meng-xia
authors.initials: MX
authors.lastname: Liu
authors.forename: Shu-li
authors.initials: SL
authors.lastname: Sheng
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009447:Neuroblastoma / Q000378:metabolism / Q000473:pathology*; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007770:L-Lactate Dehydrogenase