title: No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations.
abstract: Histamine plays an important role in the allergic inflammation. Histamin N-Methyltransferase (HNMT) catalyses the major pathway of histamine metabolism in the human lung. A common functional single nucleotide polymorphism (SNP) within the HNMT gene (C314T) was recently related to asthma. We tested this SNP for associations with asthma and asthma associated traits in two German pediatric populations (1. MAS-cohort, n=888, 85 children with asthma; 2. asthmatic children from Freiburg, n=176). Non-asthmatic (n=515) and non-atopic (n=211) children from the MAS-cohort were used as controls. For genotyping melting curve analyses (Light Cycler System) were applied. In contrast to a previous study, no association of the HNMT 314T allele with asthma, bronchial hyperresponsiveness (BHR) or other asthma related phenotypes could be observed in either study population. We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children.
authors.affiliation: Department of Pediatric Pneumology and Immunology, Charité- Humboldt University, Berlin, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Deindl
authors.forename: Silvija
authors.initials: S
authors.lastname: Peri-Jerkan
authors.forename: Klaus
authors.initials: K
authors.lastname: Deichmann
authors.forename: Bodo
authors.initials: B
authors.lastname: Niggemann
authors.forename: Susanne
authors.initials: S
authors.lastname: Lau
authors.forename: Christine
authors.initials: C
authors.lastname: Sommerfeld
authors.forename: Claudia
authors.initials: C
authors.lastname: Sengler
authors.forename: Sebastian
authors.initials: S
authors.lastname: Müller
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wahn
authors.forename: Renate
authors.initials: R
authors.lastname: Nickel
authors.forename: Andrea
authors.initials: A
authors.lastname: Heinzmann
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D016535:Bronchial Hyperreactivity / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006632:Histamine / Q000378:metabolism; D006637:Histamine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics / Q000502:physiology*
chemical_list: D006632:Histamine; D006637:Histamine N-Methyltransferase