crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling.
The Twisted gastrulation (Tsg) proteins are modulators of bone morphogenetic protein (BMP) activity in both vertebrates and insects. We find that the crossveinless (cv) gene of Drosophila encodes a new tsg-like gene. Genetic experiments show that cv, similarly to tsg, interacts with short gastrulation (sog) to modulate BMP signalling. Despite this common property, Cv shows a different BMP ligand specificity as compared with Tsg, and its expression is limited to the developing wing. These findings and the presence of two types of Tsg-like protein in several insects suggest that Cv represents a subgroup of the Tsg-like BMP-modulating proteins.
Vilmos
Peter
P
Department of Developmental and Cell Biology, Developmental Biology Center, University of California at Irvine, Irvine, California 92697, USA.
Sousa-Neves
Rui
R
Lukacsovich
Tamas
T
Marsh
J Lawrence
JL
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism*; D004058:Diffusion; D029721:Drosophila Proteins / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D023281:Genomics; D008024:Ligands; D008297:Male; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017384:Sequence Deletion / Q000235:genetics; D015398:Signal Transduction; D013379:Substrate Specificity; D014921:Wings, Animal / Q000254:growth & development / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; D029721:Drosophila Proteins; D008024:Ligands; C090223:TSG protein, Drosophila; C091428:sog protein, Drosophila