Genetic hair and nail disorders.
Hair and nails are skin appendages that share with other ectodermal tissues a common developmental pathway. Inherited disorders affecting these two structures therefore very often involve other epithelial components and present with multiple anomalies, generating both physical and psychological distress among patients and their families. The present review briefly describes major recent advances in our understanding of hair and nail genodermatoses.
Sprecher
Eli
E
Department of Dermatology and the Laboratory of Molecular Dermatology, Rambam Medical Center, Haifa 31096, Israel. e_sprecher@rambam.health.gov.il
D004476:Ectodermal Dysplasia / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D005260:Female; D018507:Gene Expression Regulation, Developmental; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006201:Hair Diseases / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D006801:Humans; D007039:Hypotrichosis / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D015994:Incidence; D008297:Male; D009260:Nail Diseases / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D009261:Nail-Patella Syndrome / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D011379:Prognosis; D018570:Risk Assessment; D012873:Skin Diseases, Genetic / Q000175:diagnosis / Q000453:epidemiology