A new bis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity.
Novel bis-andrographolide ether (1) and six known compounds andrographolide, 14-deoxy-11,12-didehydroandrographolide, andrograpanin, 14-deoxyandrographolide, (+/-)-5-hydroxy-7,8-dimethoxyflavanone, and 5-hydroxy-7,8-dimethoxyflavone have been isolated from the aerial parts of Andrographis paniculata and their structures were established by spectral data. All the isolates were tested for the anti-HIV and cytotoxic activity.
Reddy
V L Niranjan
VL
Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Reddy
S Malla
SM
Ravikanth
V
V
Krishnaiah
P
P
Goud
T Venkateshwar
TV
Rao
T P
TP
Ram
T Siva
TS
Gonnade
Rajesh G
RG
Bhadbhade
Mohan
M
Venkateswarlu
Y
Y
D035685:Andrographis / Q000737:chemistry*; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004987:Ethers; D047309:Flavones / Q000302:isolation & purification* / Q000494:pharmacology; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests
D000998:Antiviral Agents; D004224:Diterpenes; D004987:Ethers; D047309:Flavones; C030419:andrographolide