title: Salt intake and progression of chronic kidney disease: an overlooked modifiable exposure? A commentary.
abstract: The relationship between sodium chloride (salt) intake and blood pressure and cardiovascular disease has been debated for decades. Overlooked is whether there is a relationship between dietary electrolyte ingestion (both sodium and potassium) and risk for progression of kidney disease, particularly in patients who manifest early evidence of chronic kidney disease (CKD). Patients with CKD often are salt sensitive and respond to increased ingestion of sodium chloride with increased blood pressure. Of concern is the clinical evidence that salt-sensitive patients respond to increased salt intake, in the physiological range, with increased glomerular filtration fraction and proteinuria. Thus, these salt-induced changes in both systemic blood pressure and the renal microcirculation create a favorable theoretical scenario for progressive renal injury. Increased salt intake also attenuates the antihypertensive effects of most antihypertensive drugs. Consequently, salt intake must be considered a potential modifiable risk factor for the progression of kidney disease.
authors.affiliation: Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA. mweir@medicine.umaryland.edu
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Weir
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Fink
mesh_terms: D000818:Animals; D002908:Chronic Disease; D005247:Feeding Behavior; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D017673:Sodium Chloride, Dietary / Q000378:metabolism*
chemical_list: D017673:Sodium Chloride, Dietary