title: No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study.
abstract: Previous studies have demonstrated that polymorphisms in the putative promoter region of the human serotonin receptor 1B (HTR1B) gene affect gene expression [H.F. Sun, Y.T. Chang, C.S. Fann, C.J. Chang, Y.H. Chen, Y.P. Hsu, W.Y. Yu, A.T. Cheng, Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han, Biol. Psychiatry 51 (2002) 896-901; J. Duan, A.R. Sanders, J.E. Molen, L. Martinolich, B.J. Mowry, D.F. Levinson, R.R. Crowe, J.M. Silverman, P.V. Gejman, Polymorphisms in the 5'-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression, Mol. Psychiatry 8 (2003) 901-910]. And the silent mutation G861C allele has been reported to be associated with several psychiatric disorders. Thus, we performed a case-control association study (456 cases and 557 controls) of the five variants in HTR1B gene (T-261G, -182INS/DEL-181, A-161T, C129T and G861C) with schizophrenia. The results showed that neither the allelic distribution nor the major haplotype distribution (except for a rare haplotype) of five SNPs in patients was significantly different from that in controls. A further family-based association study (229 family trios) of G861C allele suggested that HTR1B was not a susceptible gene with schizophrenia in our sample. In conclusion, these data do not support the idea that HTR1B gene plays a major role in the etiopathogenesis of schizophrenia in Chinese Han population.
authors.affiliation: Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, China.
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
authors.forename: Hua
authors.initials: H
authors.lastname: Yin
authors.forename: Wuyan
authors.initials: W
authors.lastname: Chen
authors.forename: Qinhe
authors.initials: Q
authors.lastname: Xing
authors.forename: Qi
authors.initials: Q
authors.lastname: chen
authors.forename: Tingwei
authors.initials: T
authors.lastname: Guo
authors.forename: Jianjun
authors.initials: J
authors.lastname: Gao
authors.forename: Xiuxia
authors.initials: X
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Gao
authors.forename: Zhuangjun
authors.initials: Z
authors.lastname: Liu
authors.forename: Niufan
authors.initials: N
authors.lastname: Gu
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D044302:Receptor, Serotonin, 5-HT1B