Role of c-Abl in the DNA damage stress response.
c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. Here we briefly review the current knowledge about c-Abl involvement in the DNA-damage stress response and its implication on cell physiology.
Shaul
Yosef
Y
Department of Molecular Genetics, Weizmann Institute of Scienc, Rehovot 76100, Israel. yosef.shaul@weizmann.ac.il
Ben-Yehoyada
Merav
M
D000818:Animals; D017209:Apoptosis; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D004789:Enzyme Activation; D006801:Humans; D011487:Protein Conformation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D016315:Proto-Oncogene Proteins c-abl / Q000378:metabolism / Q000502:physiology*
D004247:DNA; D011505:Protein-Tyrosine Kinases; D016315:Proto-Oncogene Proteins c-abl