title: A case of prolactin-secreting pituitary carcinoma and its histological findings.
abstract: Pituitary carcinomas are very rare. The diagnosis of pituitary carcinoma is defined by evidence of craniospinal and/or systemic metastasis, rather than by histological malignancies. We report a case of prolactin-secreting pituitary macroadenoma invading the cavernous sinuses at the time of initial treatment, which later metastasized to the cerebellum, medulla oblongata, and spinal axis. The patient survived approximately nine years following the initial diagnosis of a pituitary tumor and two years following the diagnosis of metastatic disease. Histological examination of the metastatic cerebellar tumor showed an adenoma with high cellularity and hyperchromasia, but no mitoses.
authors.affiliation: Department of Neurosurgery, Showa University, Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Noda
authors.forename: Ryuta
authors.initials: R
authors.lastname: Suzuki
authors.forename: Masao
authors.initials: M
authors.lastname: Moriya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itokawa
authors.forename: Jun-ichiro
authors.initials: J
authors.lastname: Asai
authors.forename: Goro
authors.initials: G
authors.lastname: Nagashima
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Fujimoto
mesh_terms: D016543:Central Nervous System Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000601:surgery; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000556:secondary* / Q000601:surgery
chemical_list: D011388:Prolactin