title: Characterization of a population presenting with suspected mold-related health effects.
abstract: BACKGROUND
  Numerous epidemiologic studies have reported a relationship between dampness and increased respiratory symptoms in adults and children, which has led to increasing concerns among the general population about potential mold-related health effects.
  
  
  OBJECTIVE
  To identify characteristics of patients with possible mold-related health effects that might help allergists better understand how to evaluate such patients in their practices.
  
  
  METHODS
  The parameters that were evaluated for the total population included age, sex, upper and lower respiratory tract symptoms, systemic symptoms, atopic status, pet ownership, smoking history, mold sensitization, mold exposure, and exposure location. Subgroups stratified by atopic status, mold sensitization, and indoor mold exposure confirmed by an environmental mold report prepared by certified industrial hygienists were also analyzed. Significant associations were determined by correlation coefficients and logistic regression analysis.
  
  
  RESULTS
  A total of 135 patients with possible mold-related health effects secondary to prolonged indoor mold exposure were evaluated. For the overall population, a strong correlation was found among atopy, mold sensitization, and sensitization to specific molds identified in the patient's environmental report. Mold intracutaneous testing was not useful for discriminating between atopic and nonatopic individuals. There were no associations among the patients' presenting symptoms, atopic status, and magnitude of mold exposure. Similar findings were identified when subgroup analysis was performed.
  
  
  CONCLUSIONS
  Patients who present with mold-related health effects manifest heterogeneous characteristics. Medical history, skin testing, and current indoor mold sampling practices have significant limitations in establishing a causal link among mold exposure health effects.
authors.affiliation: Department of Internal Medicine, Division of Immunology/Allergy Section, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
authors.forename: R Carter
authors.initials: RC
authors.lastname: Bobbitt
authors.forename: Michael S
authors.initials: MS
authors.lastname: Crandall
authors.forename: Aarti
authors.initials: A
authors.lastname: Venkataraman
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Bernstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004783:Environmental Microbiology; D005260:Female; D005658:Fungi / Q000276:immunology*; D006798:Housing; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012140:Respiratory Tract Diseases / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology*; D012189:Retrospective Studies; D012882:Skin Tests