New developments in the endoscopic surveillance of Barrett's oesophagus.
Patients with a Barrett's oesophagus are at risk for developing an adenocarcinoma of the distal oesophagus. Therefore, many patients undergo endoscopic surveillance to detect dysplasia and/or cancer at an early and curable stage. However, early neoplastic lesions are difficult to identify with standard endoscopy. In addition, the low incidence of these lesions, currently estimated at 0.5% per year, reduces the cost effectiveness of the surveillance strategy. New developments, aimed at improving the efficacy of Barrett's surveillance, focus on two areas: 1) improvement of the endoscopic detection of early neoplastic lesions; and 2) the use of alternative techniques for tissue sampling combined with molecular markers to identify patients at risk for malignant degeneration.
Bergman
J J G H M
JJ
Department of Gastroenterology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands. j.j.bergman@amc.uva.nl
Tytgat
G N J
GN
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000473:pathology; D015415:Biomarkers / Q000032:analysis; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D004945:Esophagoscopy / Q000379:methods*; D004947:Esophagus / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology
D015415:Biomarkers