title: Effect of beta radiation on TGF-beta1 and bFGF expression in hyperplastic prostatic tissues.
abstract: OBJECTIVE
  To investigate the transforming growth factor beta1 (TGF-beta1) and basic fibroblast growth factor (bFGF) expressions in benign prostatic hyperplasia (BPH) and the effect of beta-radiation.
  
  
  METHODS
  TGF-beta1 and bFGF expression was studied by means of an immunohistochemical method in nine normal prostatic (NP) tissues, 15 hyperplastic prostatic tissues and 35 hyperplastic prostatic tissues treated with 90Sr/90Y.
  
  
  RESULTS
  The TGF-beta1 expression in the epithelium and stroma of normal prostatic tissues was 68.2 % +/- 10.5 % and 29.7 % +/- 4.6 %, respectively, while it was 64.8 % +/- 9.3 % and 28.6 % +/- 4.1 %, respectively, in hyperplastic prostatic tissues. Compared with the controls, TGF-beta1 expression in the epithelia and stroma of BPH treated with 90Sr/90Y increased significantly (P <0.01). The bFGF expression in epithelia and stroma of normal prostatic tissues was 17.4 % +/- 3.7 % and 42.5 % +/- 6.8 %, respectively, and was 46.3 % +/- 8.2 % and 73.2 % +/- 12.1 %, respectively, in hyperplastic prostatic tissues. Compared with the controls, expressions of bFGF in the epithelia and stroma of BPH treated with a 90Sr/90Y prostatic hyperplasia applicator decreased significantly (P <0.01).
  
  
  CONCLUSIONS
  Exposure of beta-rays had noticeable effects on BPH tissues, enhancing TGF-beta1 expression and inhibiting bFGF expression.
authors.affiliation: Institute of Genetics and Cytology, Northeast Normal University, Changchun 130021, China.
authors.forename: Qing-Jie
authors.initials: QJ
authors.lastname: Ma
authors.forename: Xin-Quan
authors.initials: XQ
authors.lastname: Gu
authors.forename: Xia
authors.initials: X
authors.lastname: Cao
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Xiang-Bo
authors.initials: XB
authors.lastname: Kong
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Li
authors.forename: Shan-Yu
authors.initials: SY
authors.lastname: Cai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001610:Beta Particles; D016022:Case-Control Studies; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism / Q000528:radiation effects*; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism / Q000528:radiation effects; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000532:radiotherapy; D013326:Strontium Radioisotopes / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000378:metabolism / Q000528:radiation effects*; D053773:Transforming Growth Factor beta1; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
chemical_list: D013326:Strontium Radioisotopes; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D015021:Yttrium Radioisotopes; D016222:Fibroblast Growth Factor 2