New anticoagulants: beyond heparin, low-molecular-weight heparin and warfarin.
The limitations of traditional anticoagulants, heparin and warfarin, have prompted the development of new anticoagulant drugs for prevention and treatment of both venous and arterial thromboembolism. After a brief review of thrombogenesis and its regulation, this paper focuses on new anticoagulant agents in more advanced stages of clinical testing.
Bates
Shannon M
SM
Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada.
Weitz
Jeffrey I
JI
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D015507:Drugs, Investigational / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D006801:Humans; D020246:Venous Thrombosis / Q000097:blood / Q000188:drug therapy*; D014859:Warfarin / Q000494:pharmacology*
D000925:Anticoagulants; D015507:Drugs, Investigational; D006495:Heparin, Low-Molecular-Weight; D014859:Warfarin