title: Juvenile papillomatosis of the breast in a male infant with Noonan syndrome, café au lait spots, and family history of breast carcinoma.
abstract: Juvenile papillomatosis (JP) of the breast is a rare condition, usually affecting women under 30 years of age. Although this is considered a benign lesion, follow-up is recommended for the patient and family since there is an association with a family history of breast carcinoma and increased risk of development of breast carcinoma. We report an infant with JP, Noonan syndrome (NS), café au lait spots, and family history of breast carcinoma. Seven previously reported cases of JP in males exist, two occurring in infants. The association between JP and NS has not been previously reported.
authors.affiliation: Surgery Unit, Institute of Child Health and Great Ormond Street Hospital, University College London, London, United Kingdom.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Pacilli
authors.forename: Neil James
authors.initials: NJ
authors.lastname: Sebire
authors.forename: Elmo
authors.initials: E
authors.lastname: Thambapillai
authors.forename: Agostino
authors.initials: A
authors.lastname: Pierro
mesh_terms: D018567:Breast Neoplasms, Male / Q000150:complications / Q000473:pathology*; D019080:Cafe-au-Lait Spots / Q000150:complications / Q000473:pathology*; D002277:Carcinoma / Q000150:complications; D005190:Family; D006801:Humans; D007223:Infant; D008297:Male; D009634:Noonan Syndrome / Q000150:complications / Q000473:pathology*; D010212:Papilloma / Q000150:complications / Q000473:pathology*