title: Evaluation of lipid profile in adolescents during long-term use of combined oral hormonal contraceptives.
abstract: The study evaluated the effects of the long-term use of a combined oral hormonal contraceptive containing 30 microg ethinyl estradiol and 75 microg gestodene in adolescents. Thirty-three volunteers, aged from 14 to 19 years, who used the oral contraceptive for three consecutive years, were studied. Evaluation of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides was made before use and after 1, 2 and 3 years. During the 3-year study period, total cholesterol, HDL-C, LDL-C and triglyceride levels were significantly higher than previous measurements, but average values did not exceed the normal range. Compared to the first year, the second- and third-year cholesterol, HDL-C, LDL-C and triglyceride levels were not significantly different.
authors.affiliation: Family Planning Clinic, Department of Obstetrics and Gynecology, Universidade Federal de São Paulo, São Paulo CEP 09090050, Brazil. guazzelli.toco@epm.br
authors.forename: Christina Aparecida Falbo
authors.initials: CA
authors.lastname: Guazzelli
authors.forename: Prescilla Chow
authors.initials: PC
authors.lastname: Lindsey
authors.forename: Fabio Fernando
authors.initials: FF
authors.lastname: de Araújo
authors.forename: Márcia
authors.initials: M
authors.lastname: Barbieri
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Petta
authors.forename: Jose Mendes
authors.initials: JM
authors.lastname: Aldrighi
mesh_terms: D000293:Adolescent; D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D009652:Norpregnenes / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003277:Contraceptives, Oral, Combined; D008055:Lipids; D009652:Norpregnenes; D014280:Triglycerides; C033273:Gestodene; D004997:Ethinyl Estradiol