[Investigation of the effects of mexidol in escapable and inescapable emotional stress in inbred BALB/C and C57BL/6 mice].
The effect of mexidol administered in a dose of 100 mg/kg (i.p.) was studied in BALB/C and C57BL/6 mice on various emotional stress models including open field test, elevated plus-maze test, and passive avoidance conditioned reflex. Upon a single administration, the drug produces a selective anxiolytic action on BALB/C mice (experimental animals with a "passive" phenotype of the emotional stress reaction), while not inducing any sedative (tranquilizer) effect in C57BL/6 mice (belonging to the phenotype with "active" emotional stress reaction).
Kravtsova
O Iu
OIu
Voronina
T A
TA
Sariev
A K
AK
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D010847:Picolines / Q000008:administration & dosage*; D013045:Species Specificity; D013315:Stress, Psychological / Q000188:drug therapy*
D010847:Picolines; C070020:emoxypine succinate