Protein S-nitrosylation: purview and parameters.
S-nitrosylation, the covalent attachment of a nitrogen monoxide group to the thiol side chain of cysteine, has emerged as an important mechanism for dynamic, post-translational regulation of most or all main classes of protein. S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation.
Hess
Douglas T
DT
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
Matsumoto
Akio
A
Kim
Sung-Oog
SO
Marshall
Harvey E
HE
Stamler
Jonathan S
JS
D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003545:Cysteine / Q000737:chemistry; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009569:Nitric Oxide / Q000378:metabolism; D009584:Nitrogen / Q000737:chemistry*; D010084:Oxidation-Reduction; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry*; D015398:Signal Transduction; D013438:Sulfhydryl Compounds / Q000737:chemistry
D011506:Proteins; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide; D020558:GTP Phosphohydrolases; D003545:Cysteine; D009584:Nitrogen