title: Serum lipid levels during carbamazepine therapy in epileptic children.
abstract: The aim of the study was to evaluate serum lipid levels during carbamazepine therapy in epileptic children. Thirty epileptic children (18 male, 12 female; age range, 30 months to 14 years) with idiopathic or cryptogenic partial or generalized tonic-clonic seizures (13 CPS, 17 GTC) were evaluated for serum lipids at the onset and the third month of carbamazepine therapy. Carbamazepine was started at 10 mg/kg/day. Mean total cholesterol, low-density lipoprotein, very low density lipoprotein, and triglyceride levels significantly increased during treatment (P < 0.05), but mean high-density lipoprotein levels were not statistically significant throughout the study. Carbamazepine treatment alters the serum lipid profile of children in such a way that it could potentially facilitate the development of atherosclerosis.
authors.affiliation: Department of Child Neurology, Medical University of Isfahan, Isfahan, Iran. t_mahmoudian@med.mui.ac.ir
authors.forename: T
authors.initials: T
authors.lastname: Mahmoudian
authors.forename: R
authors.initials: R
authors.lastname: Iranpour
authors.forename: N
authors.initials: N
authors.lastname: Messri
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male
chemical_list: D000927:Anticonvulsants; D008055:Lipids; D002220:Carbamazepine