The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA.
Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p-glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid DNA and tRNA was shown and compared to the interaction with calf thymus DNA. Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer cells. Both plasmid DNA and p-gp complex formation were related to the chemical structures of the resistance modifiers.
Sharples
Derek
D
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK. derek.sharples@manchester.ac.uk
Spengler
Gabriella
G
Molnár
Joseph
J
Antal
Zsuzsanna
Z
Molnár
Annamária
A
Kiss
János T
JT
Szabó
József A
JA
Hilgeroth
Andreas
A
Gallo
Sandrine
S
Mahamoud
Abdallah
A
Barbe
Jacques
J
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D004247:DNA / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D019008:Drug Resistance, Neoplasm; D005449:Fluorenes / Q000737:chemistry* / Q000494:pharmacology; D019450:Genes, MDR; D006801:Humans; D015394:Molecular Structure; D010957:Plasmids / Q000235:genetics / Q000378:metabolism; D011278:Pregnanes / Q000737:chemistry* / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry* / Q000494:pharmacology; D012343:RNA, Transfer / Q000378:metabolism*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D005449:Fluorenes; D011278:Pregnanes; D011804:Quinolines; C041509:fluorene; D004247:DNA; D012343:RNA, Transfer; C427203:calf thymus DNA