IMMUNOLOGY: Enhanced: Thymic Regulation-Hidden in Plain Sight.
The thymus is the nursery where T cell precursors mature into T cells of the and lineages. In a Perspective, Rothenberg discusses intriguing findings that reveal a new level of regulation in the thymus (Silva-Santos et al.). Apparently, double-positive T cells that are destined to mature into T cells directly regulate the development of the T-cell lineage through the production of lymphotoxin and the action of a transcription factor called RORt.
Rothenberg
Ellen V
EV