Hypotensive effect of the hydroalcoholic extract from Jacaranda mimosaefolia leaves in rats.
Hypothermic and cardiovascular activities of the methanol extract of Jacaranda mimosaefolia leaves were tested. To evaluate the hypotensive properties, anesthetized rats were used and temperature, blood pressure, and cardiac frequency were recorded. In addition, the in vitro effect produced by the extract on induced contraction with norepinephrine (NE) in rat aorta rings was evaluated. The extract produced a significant hypothermic effect with a maximum at 2 h, an effect which was accompanied by hypotension and low cardiac frequency, physiological conditions that were again re-established to the following 2 h. In isolated aorta preparations norepinephrine antagonistic effect was not correlated with the presence of Ca2+, pD2 for NE was modified by the extract, an effect that could explain a blockade of the adrenergic receptors.
Nicasio
Pilar
P
Centro de Investigación Biomédica del Sur (IMSS), Argentina No. 1, Centro, 62790 Xochitepec, Morelos, México.
Meckes
Mariana
M
D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001011:Aorta; D001794:Blood Pressure / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects
D000959:Antihypertensive Agents; D010936:Plant Extracts