title: Antifungal activity of posaconazole compared with fluconazole and amphotericin B against yeasts from oropharyngeal candidiasis and other infections.
abstract: OBJECTIVE
  The in vitro antifungal activity of posaconazole was compared with that of fluconazole and amphotericin B.
  
  
  METHODS
  A microdilution method (M27-A2) was used with 331 clinical yeast isolates.
  
  
  RESULTS
  The geometric mean MICs of posaconazole, fluconazole and amphotericin B were 0.16, 0.91 and 0.15 mg/L, respectively. Posaconazole was markedly more active than fluconazole and was active against 9/11 fluconazole-resistant Candida albicans, and five Candida glabrata had an MIC of posaconazole of 16 mg/L.
  
  
  CONCLUSIONS
  These data indicate that posaconazole is a potentially effective antifungal agent for the treatment of mycoses caused by yeasts.
authors.affiliation: Departamento de Microbiología, ACIA, PO Box 10178, E-08080 Barcelona. acarrillo@ya.com
authors.forename: Alfonso-Javier
authors.initials: AJ
authors.lastname: Carrillo-Muñoz
authors.forename: Guillermo
authors.initials: G
authors.lastname: Quindós
authors.forename: Maite
authors.initials: M
authors.lastname: Ruesga
authors.forename: Rocío
authors.initials: R
authors.lastname: Alonso
authors.forename: Oscar
authors.initials: O
authors.lastname: del Valle
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Hernández-Molina
authors.forename: Paul
authors.initials: P
authors.lastname: McNicholas
authors.forename: David
authors.initials: D
authors.lastname: Loebenberg
authors.forename: Patricia
authors.initials: P
authors.lastname: Santos
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002180:Candidiasis, Oral / Q000382:microbiology*; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B; D015725:Fluconazole