[Agranulocytosis induced by an antithyroid drug in a 14-year-old girl].
A 14-year-old girl with Graves' disease developed a fever, sore throat and a severe systemic infection after being treated with antithyroid drugs for 1 year. Agranulocytosis was diagnosed. After long-term antibiotic treatment and supportive therapy she recovered. Agranulocytosis is a known side-effect of antithyroid drugs and is seen in 0.2 to 0.5% of the patients. It usually occurs within the first 3 months of treatment. Patients above the age of 40 seem to be more susceptible. Since the onset of agranulocytosis is relatively acute, routine blood monitoring is not very useful. It is more important to instruct patients who use a thyreostatic to contact their physician in case of unexplained fever or a sore throat.
Zwaveling-Soonawala
N
N
Spaarne Ziekenhuis, afd. Kindergeneeskunde, Postbus 1644, 2003 BR Haarlem.
Veenhoven
R H
RH
Wolfs
T F W
TF
Bokma
J A
JA
D000293:Adolescent; D000380:Agranulocytosis / Q000139:chemically induced* / Q000188:drug therapy; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D005334:Fever / Q000139:chemically induced; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D010612:Pharyngitis / Q000139:chemically induced; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D013956:Antithyroid Agents