BRCA1 and estrogen signaling in breast cancer.
Since the gene encoding BRCA1 was first cloned in 1994, researchers have sought to establish the molecular basis for its linkage to breast and ovarian cancer. As universal functions for this protein have emerged, questions persist concerning how its disruption can elicit cancer in a tissue- and gender-specific manner. Here, we review evidence that a functional interrelationship between BRCA1 and estrogen signaling may be involved in breast tumorigenesis.
Trauernicht
Amy M
AM
Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, USA.
Boyer
Thomas G
TG