The outcome of 400 consecutive liver grafts using the aortic perfusion-only technique.
The goal of this study is to establish the effect of cadaveric liver retrieval, using the technique of aortic perfusion only, on liver graft function, and to identify associated potential risk factors for graft dysfunction. The authors reviewed the outcome of 400 consecutive, orthotopic, cadaveric liver transplantation retrieved by the technique of aortic perfusion only. Relevant parameters pertaining to the donor, recipient, procurement, graft and peri-operative variables are analyzed to assess their influence on graft function. The univariant analysis revealed that donor age, body mass index, blood pressure, and vasopressor dependence influence graft function. Furthermore, predictors of dysfunction included prolonged anhepatic phase, transplantation duration and partial grafts. In addition, multivariant analysis revealed significant association between obesity of donors, partial graft, and dysfunction. The technique of aortic perfusion only, is a simple and reproducible procedure. The post-transplantation outcomes appear to be similar to those reported for the traditional liver procurement technique.
El-Rassi
Ziad
Z
Department of General Surgery, Division of Surgery, Saint George Hospital, P.O. Box 166 378, Achrafieh, 1100 2807, Beirut, Lebanon. zer18@hotmail.com
Barcet
Stephane
S
Mechet
Isabelle
I
Chahine
Karim
K
Bernard
Pierre
P
Chane
Lionel
L
Sagnard
Pierre
P
Delafasse
Bertrand
B
Bouffond
Yves
Y
Boillot
Olivier
O
D000328:Adult; D001011:Aorta; D002102:Cadaver; D005260:Female; D006085:Graft Survival; D006801:Humans; D008107:Liver Diseases / Q000401:mortality* / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000401:mortality; D010477:Perfusion; D012307:Risk Factors; D014019:Tissue Donors / Q000706:statistics & numerical data; D009927:Tissue and Organ Procurement; D016896:Treatment Outcome