title: Impact of body mass index on the outcome of patients with multivessel disease randomized to either coronary artery bypass grafting or stenting in the ARTS trial: The obesity paradox II?
abstract: The effect of body mass index (BMI) on outcomes after coronary artery revascularization remains controversial. We studied 1,203 patients who had multivessel coronary artery disease and underwent stenting (n = 599) or coronary artery bypass grafting (CABG; n = 604) in the Arterial Revascularization Therapies Study. Patients were assigned to 1 of 3 groups according to BMI: <25, 25 to 30, and >30 kg/m(2). At 3-year follow-up, the incidence of death, cerebrovascular events, or myocardial infarction was similar for these BMI categories regardless of the revascularization technique used. Rates of repeat revascularization procedures were significantly higher among patients who had been randomized to stenting but were similar across BMI groups. For patients who had been randomized to undergo CABG, there was a significant decrease in repeat revascularization procedures in obese patients (p = 0.03). Among patients who underwent stenting, BMI had no effect on the 3-year combined end point of rate of major adverse cardiac or cerebrovascular events. Among patients who underwent CABG, major adverse cardiac or cerebrovascular event rates were significantly lower for patients who were obese (11%) or overweight (16%) compared with patients who had a normal BMI (24%; p = 0.008). Thus, in a large cohort of patients who had multivessel coronary artery disease and underwent surgical or percutaneous revascularization, BMI had no effect on 3-year outcome of those who underwent stenting. Conversely, among patients who underwent CABG, those who were overweight or obese had a significantly better outcome than did those who had a normal BMI with regard to survival without major adverse cardiac or cerebrovascular events, mainly due to lower rates of repeat revascularization procedures.
authors.affiliation: Division of Invasive Cardiology, Rambam Medical Center, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Luis
authors.initials: L
authors.lastname: Gruberg
authors.forename: Nestor
authors.initials: N
authors.lastname: Mercado
authors.forename: Simcha
authors.initials: S
authors.lastname: Milo
authors.forename: Eric
authors.initials: E
authors.lastname: Boersma
authors.forename: Clemens
authors.initials: C
authors.lastname: Disco
authors.forename: Gerrit-Anne
authors.initials: GA
authors.lastname: van Es
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Lemos
authors.forename: Margalit
authors.initials: M
authors.lastname: Ben Tzvi
authors.forename: William
authors.initials: W
authors.lastname: Wijns
authors.forename: Felix
authors.initials: F
authors.lastname: Unger
authors.forename: Rafael
authors.initials: R
authors.lastname: Beyar
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D015992:Body Mass Index; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000401:mortality / Q000628:therapy*; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology*; D017063:Outcome Assessment, Health Care; D012086:Reoperation / Q000706:statistics & numerical data; D015607:Stents; D020521:Stroke / Q000453:epidemiology; D016019:Survival Analysis