title: Crystalloid deposits in the kidney.
abstract: Light chain-producing lymphoproliferative disorders such as multiple myeloma are frequently complicated by renal impairment. Typically, the renal biopsy of a patient with renal failure caused by multiple myeloma shows cast nephropathy, but occasionally crystals may be seen. We describe the case of a patient with acute renal failure caused by multiple myeloma in which, on renal and bone marrow biopsy, there were widespread crystalloid deposits. Crystalloid nephropathy is a very rare condition associated with multiple myeloma and other light chain-secreting disorders. An underlying lymphoproliferative disorder should be considered in the differential diagnosis if crystalloid deposits are seen on a renal or other tissue biopsy.
authors.affiliation: Renal Unit, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia.
authors.forename: Lisa Suzanne
authors.initials: LS
authors.lastname: Keller
authors.forename: Randall James
authors.initials: RJ
authors.lastname: Faull
authors.forename: Peter
authors.initials: P
authors.lastname: Smith
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Swift
authors.forename: Kym Malcolm
authors.initials: KM
authors.lastname: Bannister
authors.forename: Sophie
authors.initials: S
authors.lastname: Otto
authors.forename: Chen Au
authors.initials: CA
authors.lastname: Peh
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology*; D003460:Crystallization; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000737:chemistry*; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology*
chemical_list: D007147:Immunoglobulin Light Chains