A48G polymorphism in the D1 receptor genes associated with bipolar I disorder.
Several lines of evidence point to a role for dopamine in mood disorders and, in particular, in bipolar disorders. In line with a considerable amount of evidence, the dopamine D1 receptor gene (DRD1) is considered to be a good candidate gene for bipolar disorders. Several studies did not find any association between bipolar 1 patients and DRD1. In this study, we investigate a possible association between BP disorder and -48A/G polymorphism of the DRD1. We genotyped 107 bipolar 1 patients and 129 healthy control subjects of exclusively Sardinian descent. A statistically significant difference in genotype (chi2 = 6.29, df = 2, P = 0.042) and allele (chi2 = 5.46, df=1, P = 0.019; OR = 1.53, 95% CI = 1.08-2.16) frequencies was found, suggesting an association between the DRD1 gene and bipolar I disorder (BP I) in the Sardinian population.
Severino
Giovanni
G
Center of Clinical Psychopharmacology, Section of Clinical Pharmacology, Department of Neurosciences "B.B.Brodie", University of Cagliari and ASL 8 Cagliari, Italy.
Congiu
Donatella
D
Serreli
Claudia
C
De Lisa
Roberto
R
Chillotti
Caterina
C
Del Zompo
Maria
M
Piccardi
Maria Paola
MP
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007558:Italy; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017447:Receptors, Dopamine D1 / Q000235:genetics*
D017447:Receptors, Dopamine D1