Immune control of phagosomal bacteria by p47 GTPases.
Sequestered from the action of complement, antibody and lytic peptides, phagosomal pathogens pose a unique problem for the innate immune system both in terms of detection and disposal. An immunologically induced 47-kDa (p47) GTPase family recruited to nascent phagosomes (PGs) has provided new insights into how vertebrates deal with facultative bacteria occupying a vacuolar niche. Research over the past 2 years in particular has identified several molecular determinants that underlie the membrane trafficking functions of LRG-47 and other p47 GTPases as part of a PG remodeling program. When coupled to signals issuing from pathogen-specific Toll-like receptors, the p47 proteins may constitute a novel sensory system enlisted by mammals, birds and fish to decode the language of immune recognition against this particular class of infectious agents.
MacMicking
John D
JD
Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA. john.macmicking@yale.edu
D000818:Animals; D002415:Cats; D004285:Dogs; D020558:GTP Phosphohydrolases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D008087:Listeria / Q000276:immunology / Q000472:pathogenicity; D051379:Mice; D009161:Mycobacterium / Q000276:immunology / Q000472:pathogenicity; D010588:Phagosomes / Q000276:immunology* / Q000382:microbiology*; D051381:Rats; D012475:Salmonella / Q000276:immunology / Q000472:pathogenicity
D020558:GTP Phosphohydrolases