Teaching resources. Ras-MAPK pathways.
This Teaching Resource provides lecture notes and slides for a class covering three kinase-mediated signaling pathways and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The focus is three major signaling cascades that are implicated in cell proliferation, survival, and stress response. They are, respectively, the mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and Jun N-terminal kinase (JNK) cascades. The aim of this lecture is to review the major players of these intracellular signaling cascades in mammalian cells. In addition, emphasis is placed on understanding the dynamic, rather than linear, nature of signal transduction in determining cellular responses to external stimuli.
Chan
Andrew
A
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA. andrew.chan@mssm.edu <andrew.chan@mssm.edu>
D000818:Animals; D001296:Audiovisual Aids; D001695:Biology / Q000193:education*; D004500:Education, Graduate; D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000502:physiology; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008322:Mammals / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D018631:ras Proteins / Q000502:physiology*
D019869:Phosphatidylinositol 3-Kinases; D048031:JNK Mitogen-Activated Protein Kinases; D018631:ras Proteins