High-yield conversion of (R)-2-octanol from the corresponding racemate by stereoinversion using Candida rugosa.
Whole cells of Candida rugosa catalyzed the conversion of (R)-2-octanol from the corresponding racemate with the optical purity of 97% e.e. and yield of 92% in 10 h. The product was formed through a stereoinversion involving enantioselective oxidation and asymmetric reduction with 2-octanone as the intermediate.
Nie
Yao
Y
Key Laboratory of Industrial Biotechnology of Ministry of Education & School of Biotechnology, Southern Yangtze University, 214036, Wuxi, P.R. China.
Xu
Yan
Y
Qing Mu
Xiao
X
Tang
Yan
Y
Jiang
Juan
J
Hao Sun
Zhi
Z
D002175:Candida / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D000442:Octanols / Q000737:chemistry*; D013237:Stereoisomerism
D000442:Octanols; C067943:2-octanol