[Tuberculoma and tuberculous meningeal-radiculitis with paradoxical progression during treatment].
BACKGROUND
Neuromeningeal tuberculosis of deleterious, paradoxical, progression despite appropriate antibiotic therapy is rare.


METHODS
An immunocompetent woman exhibited an immediately disseminated form of tuberculosis with progressive neurological involvement associating expanding intracranial tuberculomas and meningeal-radiculitis despite adapted anti-tuberculosis quadritherapy.


CONCLUSIONS
During anti-tuberculosis therapy clinical worsening is rare, particularly when 2 different manifestations are associated and the worsening occurs in an immunocompetent patient. This possibility should be systematically evoked in such cases. The explanation of this phenomenon is still unclear.
Rabar
D
D
Service de maladies infectieuses et tropicales, Hôpital de la Croix-Rousse, Lyon.
Issartel
B
B
Petiot
P
P
Boibieux
A
A
Chidiac
C
C
Peyramond
D
D
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use*; D003221:Confusion / Q000382:microbiology; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever / Q000382:microbiology; D006801:Humans; D007121:Immunocompetence; D007538:Isoniazid / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D015242:Ofloxacin / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011843:Radiculopathy / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012293:Rifampin / Q000627:therapeutic use; D013129:Spinal Puncture; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014375:Tuberculoma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016862:Tuberculoma, Intracranial / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D014390:Tuberculosis, Meningeal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D000995:Antitubercular Agents; D015242:Ofloxacin; D007538:Isoniazid; D011241:Prednisone; D012293:Rifampin