title: [Analysis of CD1 molecules in the process of granuloma formation with sarcoidosis].
abstract: There have been many reports studying the presentation for lipid antigen by CD1 molecules on dendritic cells (DC), mainly in the infection of acid-fast bacilli. But little is known about the expression of CD1 molecules in sarcoidosis. In this study, we analyzed the expression of CD1 molecules by immunohistochemical stain with monoclonal anti-CD1a, CD1b and CD1c antibody for the specimens of nine sarcoidosis patients (sarcoidosis group) and seven control cases (control group). Aggregation of CD1 positive cells was present adjacent to granulomas in five cases of the sarcoidosis group, but was absent in all cases of the control group. There were no differences in the results of laboratory findings or disease activity between CD1-positive and negative cases in the sarcoidosis group. These data suggest that the presentation of lipid antigens mediated by CD1 molecules on DC is involved in granuloma formation in sarcoidosis.
authors.affiliation: Second Department of Medicine, Hamamatsu University School of Medicine.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Enomoto
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
authors.forename: Naoki
authors.initials: N
authors.lastname: Inui
authors.forename: Dai
authors.initials: D
authors.lastname: Hashimoto
authors.forename: Tateaki
authors.initials: T
authors.lastname: Naito
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Seiichi
authors.initials: S
authors.lastname: Miwa
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakano
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Koshi
authors.initials: K
authors.lastname: Yokomura
authors.forename: Kyotaro
authors.initials: K
authors.lastname: Ide
authors.forename: Kingo
authors.initials: K
authors.lastname: Chida
mesh_terms: D000328:Adult; D000368:Aged; D017951:Antigen Presentation; D018949:Antigens, CD1 / Q000032:analysis* / Q000096:biosynthesis; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D006099:Granuloma / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000150:complications*
chemical_list: D018949:Antigens, CD1