title: Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances.
abstract: Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma. Nevertheless, the validity of this heterogeneous pathological entity has been recurrently questioned by pathologists. Recently, analyses by comparative genomic hybridization (CGH) of a large series of MFHs suggested that MFHs consist of morphologic modulation of other poorly differentiated sarcomas like leiomyosarcomas (LMS) or dedifferentiated liposarcomas (DLPS). We report here an analysis by CGH of 22 myxoid MFHs (mMFH), one of the five histological subtypes of MFH, and of nine pleomorphic liposarcomas (pLPS), a rare poorly differentiated LPS. The chromosome imbalances encountered in the series of mMFH were very similar to those observed in the series of pLPS studied in the laboratory and in the series of 14 pLPS published in the literature. The most frequent gains involved chromosome subregions: pericentromeric regions of 1, 5p, 19p, 19q and 20q. Losses found in the chromosomal arms 1q, 2q, 3p, 4q, 10q, 11q and 13q were also recurrent. The use of a clustering software did not separate the two pathological groups (mMFH and pLPS) on the basis of genomic data. Moreover, pLPS-mMFH represented, according to the clustering software results, an entity clearly distinguished from other soft tissue sarcomas, LMS in particular, with which they share common genetic aberrations. Additional studies are needed to identify genes targeted by these genomic aberrations, and implicated in the oncogenesis of these tumor subtypes. The characterization of common gene alterations in both tumor groups would suggest a closer relationship between these two types of soft tissue sarcomas.
authors.affiliation: INSERM U509, Laboratoire de Pathologie Moléculaire des Cancers, Institut Curie, Paris, France.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Idbaih
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Coindre
authors.forename: Josette
authors.initials: J
authors.lastname: Derré
authors.forename: Odette
authors.initials: O
authors.lastname: Mariani
authors.forename: Philippe
authors.initials: P
authors.lastname: Terrier
authors.forename: Dominique
authors.initials: D
authors.lastname: Ranchère
authors.forename: Aline
authors.initials: A
authors.lastname: Mairal
authors.forename: Alain
authors.initials: A
authors.lastname: Aurias
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D007621:Karyotyping; D008080:Liposarcoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology