Allergic contact dermatitis from povidone-iodine: a re-evaluation study.
500 consecutive patients were patch tested with a 10% povidone-iodine (PVP-I) solution, diluted 10 times in water. Readings were made at 2 and 4 days. 14 of the 500 (2.8%) showed a positive test to PVP-I. The 14 positive patients to PVP-I were subjected to a repeated open application test (ROAT) with a PVP-I solution, as is; 2 of the 14 were recorded as positive. It was concluded that only 2 of the 500 patients had true allergic contact dermatitis from PVP-I (0.4%). This study emphasizes the need for more complete investigation, when testing with some allergens, when they share both irritant and allergenic properties, such as PVP-I. The approach is important to rule out false-positive patch test reactions and to assess true clinical relevance.
Lachapelle
Jean-Marie
JM
Department of Dermatology, Louvain University, 30 Clos Chapelle-aux-Champs, UCL 3033, B-1200 Brussels, Belgium. jean-marie.lachapelle@derm.ucl.ac.be
D000485:Allergens / Q000009:adverse effects*; D000891:Anti-Infective Agents, Local / Q000009:adverse effects* / Q000276:immunology; D001530:Belgium; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D010328:Patch Tests / Q000379:methods*; D011206:Povidone-Iodine / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors
D000485:Allergens; D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine