title: Axially chiral biaryl diols catalyze highly enantioselective hetero-Diels-Alder reactions through hydrogen bonding.
abstract: Axially chiral 1,1'-biaryl-2,2'-dimethanol (3, BAMOL) family of diols are highly effective catalysts for enantioselective hetero-Diels-Alder reactions between aminosiloxydiene 1 and a wide variety of unactivated aldehydes. The reactions proceed in useful yields and excellent enantioselectivities. The diols function in the same capacity as Lewis acids, by activating the aldehyde carbonyl group through hydrogen bonding.
authors.affiliation: Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, IL 60637, USA.
authors.forename: Aditya K
authors.initials: AK
authors.lastname: Unni
authors.forename: Norito
authors.initials: N
authors.lastname: Takenaka
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Viresh H
authors.initials: VH
authors.lastname: Rawal