title: Agents protecting against sepsis from the roots of Angelica dahurica.
abstract: In the course of isolating agents preventing sepsis from the EtOAc extract of the roots of Angelica dahurica, four known furanocoumarins, isoimperatorin (1), oxypeucedanin (2), (+/-)-byakangelicin (3), and (+)-oxypeucedanin hydrate (4), were isolated as active compounds based on the in vivo assay model of sepsis induced by lipopolysaccharide (LPS) and D-galactosamine (D-GalN). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 20% for the control experiment) and decreased the plasma levels of tumor necrosis factor-alpha and alanine aminotransferase in mice adminstered LPS/D-GalN.
authors.affiliation: Department of Pharmacology, Hallym University College of Medicine, Institute of Natural Medicine, Chunchon 200-702, Republic of Korea.
authors.forename: Dong-Keun
authors.initials: DK
authors.lastname: Song
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Gao
authors.initials: G
authors.lastname: Li
authors.forename: Kyeung-Seon
authors.initials: KS
authors.lastname: Lee
authors.forename: Chang-Seob
authors.initials: CS
authors.lastname: Seo
authors.forename: Ji-Jing
authors.initials: JJ
authors.lastname: Yan
authors.forename: Jun-Sub
authors.initials: JS
authors.lastname: Jung
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hyun-Wook
authors.initials: HW
authors.lastname: Chang
authors.forename: Jong-Keun
authors.initials: JK
authors.lastname: Son
mesh_terms: D029969:Angelica; D000818:Animals; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D018517:Plant Roots; D018805:Sepsis / Q000097:blood / Q000517:prevention & control*
chemical_list: D010936:Plant Extracts