Magnetic resonance perfusion tracks 133Xe cerebral blood flow changes after carotid stenting.
OBJECTIVE
To compare magnetic resonance (MR) perfusion to gold-standard cerebral blood flow (CBF) determined by intra-arterial (133)Xe washout method.


METHODS
Eight patients with high-grade carotid stenoses underwent bolus-tracking MR perfusion and intra-arterial (133)Xe washout before and after carotid stenting. MR perfusion was compared with 133Xe-CBF values using Pearson linear correlation analysis.


RESULTS
We observed a mean 37+/-38% increase in 133Xe-CBF and a mean 19+/-27% increase in relative CBF (rCBF) by MR perfusion immediately after stent placement. Relative (percent) changes in MR-rCBF showed a close and linear correlation to those seen in 133Xe-CBF (r=0.91; R2=0.84; P=0.002). There was a trend for MR perfusion to underestimate change in CBF at higher relative changes in flow.


CONCLUSIONS
Bolus-tracking MR perfusion correlates with 133Xe-CBF in estimating postprocedural increases in blood flow but may underestimate the magnitude of the change with higher relative changes.
Ko
Nerissa U
NU
Department of Neurology, University of California, San Francisco, USA.
Achrol
Achal S
AS
Martin
Alastair J
AJ
Chopra
Manju
M
Saloner
David A
DA
Higashida
Randall T
RT
Young
William L
WL
D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D016893:Carotid Stenosis; D002560:Cerebrovascular Circulation; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015607:Stents; D014980:Xenon Radioisotopes / Q000032:analysis*
D014980:Xenon Radioisotopes