title: Mastication influences the survival of newly generated cells in mouse dentate gyrus.
abstract: We examined the effects of soft food and tooth loss on neurogenesis in the adult dentate gyrus. Four-week-old mice were subjected to a powder diet for 10 weeks with or without removal of molars. They received a daily injection of bromodeoxyuridine (BrdU) at 14 weeks of age for 12 consecutive days. The number of BrdU-positive cells in the dentate gyrus of these mice did not differ from that of control at 1 day after the last BrdU injection. However, the BrdU-positive cells in these mice showed a larger reduction in number than in control at 5 weeks after the BrdU injection and the ratio of neurons to BrdU-positive cells decreased in the molarless mice. These results suggest that mastication influences the survival of newly generated cells in the adult dentate gyrus.
authors.affiliation: Oral Functional Science, Hokkaido University Graduate School of Dental Medicine, N13W7 Kita-ku, Sapporo 060-8586, Japan. mmit@den.hokudai.ac.jp
authors.forename: Masato
authors.initials: M
authors.lastname: Mitome
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shirakawa
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D002454:Cell Differentiation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D018891:Dentate Gyrus / Q000166:cytology* / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry / Q000379:methods; D008409:Mastication / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology*
chemical_list: D010751:Phosphopyruvate Hydratase; D001973:Bromodeoxyuridine