[Effect of qilong capsule on hemoreology in acute stress blood stasis rats].
OBJECTIVE
To study the influence of Qilong capsule (QLC) on the hemoreology in acute stress blood stasis model rats.


METHODS
The model of acute stress blood stasis rats were induced by putting the rats into ice-water between hyodermic epinephrine twice of 1 mg x kg(-1). With the models, the effect of QLC on hemoreology such as whole blood viscosity, whole blood reduction viscosity, plasma viscosity, haematocrit (Hct), erythrocyte deformation and erythrocyte aggregation were observed.


RESULTS
QLC 0.6, 0.3, 0.15 g x kg(-1) could significantly reduce the increase of whole blood viscosity at high-middle-low shear rate, reduce the whole blood reduction viscosity at middle-low shear rate, reduce Hct and erythrocyte aggregation, and increase the erythrocyte deformation in acute stress blood stasis rats (P < 0.05, P < 0.01, compared with vehicle). QLC 0.6, 0.3 g x kg(-1) could also reduce plasma viscosity (P < 0.05, P < 0.01, compared with vehicle).


CONCLUSIONS
QLC can significantly improve some indexes of hemoreology in acute stress blood stasis rats.
Wu
Yan
Y
Department of Pharmacology, Beijing University of Chinese Medicine, Beijing 100102, China.
Sun
Jian-ning
JN
D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry; D001809:Blood Viscosity / Q000187:drug effects; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D018056:Hemorheology / Q000187:drug effects*; D006487:Hemostasis / Q000187:drug effects*; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D009835:Oligochaeta / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013312:Stress, Physiological / Q000503:physiopathology*
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica