New antiproliferative benzoindolinothiazepines derivatives.
New benzoindolinothiazepines containing a piperazine moiety are described as potent antiproliferative agents against PC3 human prostatic cell lines. This activity could be explained by an accumulation of cells in G1 phase.
Laconde
Guillaume
G
Institut de chimie pharmaceutique Albert Lespagnol, universite de Lille 2, EA 2692, 3, rue du Professeur Laguesse, B.P. 83, 59006 Lille cedex, France.
Depreux
Patrick
P
Berthelot
Pascal
P
Pommery
Nicole
N
Hénichart
Jean-Pierre
JP
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D016193:G1 Phase / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008297:Male; D008956:Models, Chemical; D011471:Prostatic Neoplasms / Q000378:metabolism; D013841:Thiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013841:Thiazepines