Induction and suppression of RNA silencing: insights from viral infections.
In eukaryotes, small RNA molecules engage in sequence-specific interactions to inhibit gene expression by RNA silencing. This process fulfils fundamental regulatory roles, as well as antiviral functions, through the activities of microRNAs and small interfering RNAs. As a counter-defence mechanism, viruses have evolved various anti-silencing strategies that are being progressively unravelled. These studies have not only highlighted our basic understanding of host-parasite interactions, but also provide key insights into the diversity, regulation and evolution of RNA-silencing pathways.
Voinnet
Olivier
O
Institut de Biologie Moléculaire des Plantes du CNRS, 12 Rue du Général Zimmer, 67084 Strasbourg Cedex, France. olivier.voinnet@ibmp-ulp.u-strasbg.fr
D000818:Animals; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006790:Host-Parasite Interactions; D006801:Humans; D007109:Immunity; D035683:MicroRNAs; D010944:Plants / Q000235:genetics; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000502:physiology; D014777:Virus Diseases / Q000235:genetics*; D018406:Virus Physiological Phenomena
D035683:MicroRNAs; D034741:RNA, Small Interfering