title: Novel renal amino acid transporters.
abstract: Reabsorption of amino acids, similar to that of glucose, is a major task of the proximal kidney tubule. Various amino acids are actively transported across the luminal brush border membrane into proximal tubule epithelial cells, most of which by cotransport. An important player is the newly identified cotransporter (symporter) B0AT1 (SLC6A19), which imports a broad range of neutral amino acids together with Na+ across the luminal membrane and which is defective in Hartnup disorder. In contrast, cationic amino acids and cystine are taken up in exchange for recycled neutral amino acids by the heterodimeric cystinuria transporter. The basolateral release of some neutral amino acids into the extracellular space is mediated by unidirectional efflux transporters, analogous to GLUT2, that have not yet been definitively identified. Additionally, cationic amino acids and some other neutral amino acids leave the cell basolaterally via heterodimeric obligatory exchangers.
authors.affiliation: University of Zurich, Institute of Physiology, CH-8057 Zurich, Switzerland. verrey@access.unizh.ch
authors.forename: François
authors.initials: F
authors.lastname: Verrey
authors.forename: Zorica
authors.initials: Z
authors.lastname: Ristic
authors.forename: Elisa
authors.initials: E
authors.lastname: Romeo
authors.forename: Tamara
authors.initials: T
authors.lastname: Ramadan
authors.forename: Victoria
authors.initials: V
authors.lastname: Makrides
authors.forename: Mital H
authors.initials: MH
authors.lastname: Dave
authors.forename: Carsten A
authors.initials: CA
authors.lastname: Wagner
authors.forename: Simone M R
authors.initials: SM
authors.lastname: Camargo
mesh_terms: D026905:Amino Acid Transport Systems / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007668:Kidney / Q000378:metabolism*
chemical_list: D026905:Amino Acid Transport Systems