A second-generation genome screen for linkage to type 1 diabetes in a Bedouin Arab family.
IDDM17 on chromosome 10 was identified in an initial genome screen of 13 members (10 affected) of a large Bedouin Arab family that had 19 relatives affected with type 1 diabetes. Two more children have now been diagnosed with the disease. A second genome screen with 45 members (17 affected members, spouses, and offspring; 382 markers) was performed. A parallel version of Genehunter was used for parametric and nonparametric linkage analyses. The nonparametric linkage analysis (NPL) confirmed the IDDM17 locus (NPL = 3.79; P = 0.001) with a prominent LOD (logarithm of the odds = 2.38) peak. These results demonstrate the strong potential of genetically homogenous, extended families for mapping genes that contribute to a complex disease.
Babu
Sunanda R
SR
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA. Sunanda.Babu@uchsc.edu
Conant
Gavin C
GC
Eller
Elise
E
Roberts
Christine M
CM
Gowan
Katherine
K
Eisenbarth
George S
GS
Fain
Pamela R
PR
Vardi
Pnina
P
D018912:Arabs / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D018709:Statistics, Nonparametric
D005819:Genetic Markers