Increased C reactive protein in response to acute stress in patients with rheumatoid arthritis.
OBJECTIVE
To assess the effects of acute stress on inflammatory, haemostatic, rheological, and haemodynamic activity in patients with rheumatoid arthritis (RA) in comparison with patients with osteoarthritis (OA).


METHODS
21 patients with RA and 10 with OA underwent a brief mental stress task while standing. Inflammatory, haemostatic, rheological, and haemodynamic variables were measured at baseline, during the task, and at recovery.


RESULTS
At baseline, erythrocyte sedimentation rate and fibrinogen were higher in RA than OA. White blood cell count, fibrinogen, blood pressure, and pulse rate increased, whereas prothrombin time and plasma volume decreased during the task in both patient groups. The stress task increased C reactive protein (CRP) only in patients with RA, and more specifically in those patients with RA with high disease activity.


CONCLUSIONS
The increase in the inflammatory marker CRP, which was specific to patients with RA, combined with the haemostatic, rheological, and haemodynamic reactions to the stress task, over and above the already high baseline levels, could underlie the increased risk for myocardial infarction in this vulnerable patient group.
Veldhuijzen van Zanten
J J C S
JJ
School of Sport and Exercise Sciences, University of Birmingham, Birmingham B15 2TT, UK. veldhujj@bham.ac.uk
Ring
C
C
Carroll
D
D
Kitas
G D
GD
D000208:Acute Disease; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D001794:Blood Pressure; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006339:Heart Rate; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood / Q000150:complications; D010953:Plasma Volume; D011517:Prothrombin Time; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000097:blood / Q000150:complications* / Q000503:physiopathology
D005340:Fibrinogen; D002097:C-Reactive Protein