Preserved myocardial [123I]metaiodobenzylguanidine uptake in autosomal recessive juvenile parkinsonism: first case report.
A decrease in myocardial uptake of iodine-123-labeled metaiodobenzylguanidine (123I-MIBG) has been reported in idiopathic Parkinson's disease (PD) using 123I-MIBG myocardial scintigraphy. However, the patient with autosomal recessive juvenile parkinsonism (AR-JP), caused by the parkin gene, presented here showed normal 123I-MIBG myocardial uptake, suggesting that AR-JP is a distinct disease entity from PD. Although the clinical features of AR-JP are sometimes quite similar to those of late-onset idiopathic PD, 123I-MIBG myocardial scintigraphy may be a powerful tool to differentiate PD from other parkinsonian syndromes, including AR-JP.
Suzuki
Masahiko
M
Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan. suzukimd@jikei.ac.jp
Hattori
Nobutaka
N
Orimo
Satoshi
S
Fukumitsu
Nobuyoshi
N
Abo
Masahiro
M
Kono
Yu
Y
Sengoku
Renpei
R
Kurita
Akira
A
Honda
Hidehiko
H
Inoue
Kiyoharu
K
D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics*; D005091:Exons / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging* / Q000235:genetics*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine