[Primary research of pharmacological effects of PEC on mice].
OBJECTIVE
To study pharmacological effects of PEC (the oral liquid which consists of Panax quinquefolium, Epimedium brevicornum, Schisandra chinensis Bail and Cervus eplaphus) on mice.


METHODS
Experiments were carried out through swimming test, step-through, spontaneous activity and sleeping time.


RESULTS
When 5-10 mL x kg(-1) of PEC was given orally for 7 days, it could prolong swimming duration of mice in water tank, and increase the tolerant ability against oxygen-deficiency. PEC could also improve cognitive-deficiency induced by taking off sleep with force in mice after given orally for 7 days. The PEC could increase the spontaneous activity in mice, antagonize the inhabitation induced by Valium, and shorten the sleeping time caused by sodium pentobarbital.


CONCLUSIONS
PEC has strong potential neuro-pharmacological activities such as anti-fatigue, improving cognitive-deficiency in mice.
Wang
Li-wei
LW
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100094, China.
Liu
Xin-min
XM
Lu
Guang-hua
GH
Gao
Nan-nan
NN
Xiao
Pei-gen
PG
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D034181:Epimedium / Q000737:chemistry; D005221:Fatigue / Q000188:drug therapy*; D000860:Hypoxia / Q000188:drug therapy; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy*; D051379:Mice; D005894:Panax / Q000737:chemistry; D010424:Pentobarbital / Q000494:pharmacology; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry; D012890:Sleep / Q000187:drug effects; D013550:Swimming
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010424:Pentobarbital