title: Enhanced expression of PP1gamma1, a catalytic subunit isoform of protein phosphatase type1 and expression of telomerase activity in Ewing's sarcoma cells.
abstract: We previously reported that PP1gamma1 is highly expressed in osteosarcoma and chondrosarcoma, and suggested that this protein plays a role in malignancy of osteogenic tumors. In this study, we investigated the correlation of the expression of PP1gamma1 with telomerase activity. PP2A protein was not positive in any of the 5 cases of Ewing's sarcoma, but PP1gamma1 protein was strongly positive in all cases. Furthermore, malignant cells had high telomerase activity. We investigated the correlation of the expression of PP1gamma1 with telomerase activity, and showed that telomerase activity is regulated by protein phosphorylation in Ewing's sarcoma cells.
authors.affiliation: Department of Orthopaedic Surgery, Kagawa Medical College, Miki-cho, Kagawa 761-0701, Japan. stmori@kms.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mori
authors.forename: Yongping
authors.initials: Y
authors.lastname: Cao
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamadab
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sogawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kondo
authors.forename: Norifumi
authors.initials: N
authors.lastname: Hino
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Yoji
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Shiro
authors.initials: S
authors.lastname: Oka
authors.forename: Kojiro
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Tasuku
authors.initials: T
authors.lastname: Mashiba
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Norimatsu
mesh_terms: D002813:Chondrosarcoma / Q000378:metabolism; D006801:Humans; D012516:Osteosarcoma / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000502:physiology*; D010766:Phosphorylation; D012512:Sarcoma, Ewing / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D019098:Telomerase / Q000378:metabolism*
chemical_list: D019098:Telomerase; D010749:Phosphoprotein Phosphatases