title: Resective surgery to treat refractory status epilepticus in children with focal epileptogenesis.
abstract: Prolonged high-dose suppressive therapy (HDST) is a mainstay in the management of refractory status epilepticus (RSE), albeit with high morbidity and mortality. The authors studied 10 patients who were carefully selected for epilepsy surgery after failing prolonged (>2 weeks) HDST. Status epilepticus was stopped acutely in all of them with no mortality and no substantial morbidity. At follow-up (median 7 months), 7 (70%) of 10 patients were seizure free, and 3 (30%) of 10 had significant improvement in their epilepsy.
authors.affiliation: Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: A
authors.initials: A
authors.lastname: Alexopoulos
authors.forename: D K
authors.initials: DK
authors.lastname: Lachhwani
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: P
authors.initials: P
authors.lastname: Kotagal
authors.forename: A M
authors.initials: AM
authors.lastname: Harrison
authors.forename: W
authors.initials: W
authors.lastname: Bingaman
authors.forename: E
authors.initials: E
authors.lastname: Wyllie
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000002:abnormalities; D002648:Child; D003131:Combined Modality Therapy; D004660:Encephalitis / Q000150:complications; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006423:Hemianopsia / Q000453:epidemiology; D038421:Hemispherectomy; D006801:Humans; D007223:Infant; D020244:Infarction, Middle Cerebral Artery / Q000150:complications; D008297:Male; D010291:Paresis / Q000209:etiology; D011183:Postoperative Complications; D012189:Retrospective Studies; D013226:Status Epilepticus / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000150:complications
chemical_list: D000927:Anticonvulsants