title: Catechol releases iron(III) from ferritin by direct chelation without iron(II) production.
abstract: It has been traditionally considered that catechols release iron from ferritin by reduction to iron(II), which diffuses through the ferritin channels into the intracellular milieu where it participates in the Fenton reaction, producing highly toxic hydroxyl radicals. However, in the present work we have proved that the mechanism of the release of iron from ferritin by catechol does not take place by iron(II) reduction but by direct iron(III) chelation and therefore without iron(II) production. A possible extension of these findings to other catechols is discussed on the basis of the stability with respect to the internal redox reaction of the iron(III)-catechol complexes.
authors.affiliation: Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, 18071, Granada, Spain.
authors.forename: Purificación
authors.initials: P
authors.lastname: Sánchez
authors.forename: Natividad
authors.initials: N
authors.lastname: Gálvez
authors.forename: Enrique
authors.initials: E
authors.lastname: Colacio
authors.forename: Elena
authors.initials: E
authors.lastname: Miñones
authors.forename: José M
authors.initials: JM
authors.lastname: Domínguez-Vera
mesh_terms: D002396:Catechols / Q000494:pharmacology*; D002614:Chelating Agents / Q000494:pharmacology*; D005293:Ferritins / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D002396:Catechols; D002614:Chelating Agents; D005293:Ferritins; D007501:Iron; C034221:catechol