title: Coeliac disease, unilateral occipital calcifications, and drug-resistant epilepsy: successful lesionectomy.
abstract: OBJECTIVE
  To draw attention to the triad of coeliac disease (CD), occipital calcifications, and drug-resistant epilepsy, with focus on the outcome of epilepsy surgery.
  
  
  METHODS
  We describe a male patient who despite a diagnosis of CD from the age of 9 did not comply with the gluten-free diet. At the age of 11 he developed simple and complex partial seizures with visual symptoms, anxiety, and ambulatory automatisms. His epilepsy appeared to be drug resistant, and after having tried nine antiepileptic drugs (AEDs), alone or in combinations, he underwent a presurgical evaluation at the age of 30. Interictal standard electroencephalograms (EEGs) disclosed frequent biparieto-occipital epileptiform discharges. Computed tomography showed cortical-subcortical punctate calcifications in the right parieto-occipital region, where his seizures seemed to start, according to ictal EEG registrations from intracranial strip electrodes.
  
  
  RESULTS
  At the age of 31 he underwent epilepsy surgery. A 5 x 6 cm large area of the right parieto-occipital region was resected, including the area with calcifications. Except for a few short-lasting episodes of anxiety (simple partial seizures?) he has now been seizure-free for 12 years. AEDs were withdrawn 5 years ago. Postoperatively he was left with an upper left-sided quadrant anopsia, which is not bothering him.
  
  
  CONCLUSIONS
  In patients with CD, unilateral occipital calcifications, and drug-resistant epilepsy, epilepsy surgery should be considered, as a lesionectomy might be very successful.
authors.affiliation: National Centre for Epilepsy, Sandvika, Norway. karl.otto.nakken@epilepsy.no
authors.forename: K O
authors.initials: KO
authors.lastname: Nakken
authors.forename: G K
authors.initials: GK
authors.lastname: Røste
authors.forename: E
authors.initials: E
authors.lastname: Hauglie-Hanssen
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000150:complications* / Q000178:diet therapy; D003649:Decalcification, Pathologic / Q000473:pathology* / Q000601:surgery*; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D005983:Glutens; D006801:Humans; D008297:Male; D009778:Occipital Lobe / Q000473:pathology / Q000601:surgery
chemical_list: D005983:Glutens