Genetics of hypertension: lessons learnt from mendelian and polygenic syndromes.
This brief review discusses genetic and genomic aspects of hypertension. A special emphasis is given to currently available strategies for gene identifications, including studies of rare Mendelian hypertension, candidate gene evaluation, genome-wide scans and approaches based on the comparative genome analysis. We also discuss the growing potential for pharmacogenetic approaches and address briefly the issue of genetic testing in complex polygenic traits.
Dominiczak
Anna F
AF
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Western Infirmary, Glasgow, Scotland, UK. ad7e@clinmed.gla.ac.uk
Brain
Nick
N
Charchar
Fadi
F
McBride
Martin
M
Hanlon
Neil
N
Lee
Wai Kwong
WK
D023281:Genomics; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D020412:Multifactorial Inheritance; D020641:Polymorphism, Single Nucleotide