title: Evaluation of dynamic headspace with gas chromatography/mass spectrometry for the determination of 1,1,1-trichloroethane, trichloroethanol, and trichloroacetic acid in biological samples.
abstract: A sensitive and reproducible method is described for the analysis of trichloroacetic acid in urine and 1,1,1-trichloroethane in blood using dynamic headspace GC/MS. Samples were analyzed using the soil module of a modified purge and trap autosampler to facilitate the use of disposable purging vessels. Coefficients of variation were below 3.5% for both analytes, and response was linear in the range of 0.01-7.0 microg/ml for trichloroacetic acid and 0.9 ng/ml-2.2 microg/ml for 1,1,1-trichloroethane. Attempts at using dynamic headspace for the analysis of trichloroethanol in urine were unsuccessful.
authors.affiliation: Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195-7234, USA. djohns@u.washington.edu
authors.forename: Douglas O
authors.initials: DO
authors.lastname: Johns
authors.forename: Russell L
authors.initials: RL
authors.lastname: Dills
authors.forename: Michael S
authors.initials: MS
authors.lastname: Morgan
mesh_terms: D005023:Ethylene Chlorohydrin / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D014238:Trichloroacetic Acid / Q000032:analysis* / Q000097:blood / Q000652:urine; D014240:Trichloroethanes / Q000032:analysis* / Q000097:blood / Q000652:urine
chemical_list: D014240:Trichloroethanes; C024566:1,1,1-trichloroethane; D014238:Trichloroacetic Acid; D005023:Ethylene Chlorohydrin; C005849:2,2,2-trichloroethanol