Exacerbation of symptoms due to diltiazem in a patient with Lambert-Eaton myasthenic myopathic syndrome.
A 65-year old man on treatment for ischaemic heart disease presented with a history of pain and weakness of all four limbs and dry mouth. He had clinical and neurophysiological features of Lambert-Eaton myasthenic syndrome. His symptoms improved after withdrawal of diltiazem, although neurophysiological changes remained even after 3 months.
Pathirana
K D
KD
University Medical Unit, Teaching Hospital Karapitiya, Galle, Sri Lanka. kithsiripathirana@yahoo.com
Hidelaratchi
M D P
MD
D000368:Aged; D004110:Diltiazem / Q000009:adverse effects* / Q000627:therapeutic use; D018450:Disease Progression; D004576:Electromyography; D005500:Follow-Up Studies; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications / Q000175:diagnosis*; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D009460:Neurologic Examination; D018570:Risk Assessment; D012720:Severity of Illness Index; D013188:Sri Lanka
D004110:Diltiazem