title: Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: report of two new cases and subject review.
abstract: Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.
authors.affiliation: Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA.
authors.forename: Susanna L
authors.initials: SL
authors.lastname: Matsen
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Yeo
authors.forename: Ralph H
authors.initials: RH
authors.lastname: Hruban
authors.forename: Michael A
authors.initials: MA
authors.lastname: Choti
mesh_terms: D000328:Adult; D005260:Female; D006498:Hepatectomy; D006801:Humans; D006934:Hypercalcemia / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D016577:Pancreaticoduodenectomy; D044162:Parathyroid Hormone-Related Protein / Q000032:analysis* / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000503:physiopathology; D013577:Syndrome; D014057:Tomography, X-Ray Computed
chemical_list: D044162:Parathyroid Hormone-Related Protein