Development of consensus guidelines for anticardiolipin and lupus anticoagulant testing.
Interlaboratory and intermethod variation in commercial and in-house tests used for the measurement of anticardiolipin antibodies (aCL) and lupus anticoagulant (LA) limit the diagnostic value of the results from these tests. This short review summarizes published and unpublished guidelines (some developed using consensus procedures) on aCL and LA testing that are aimed at decreasing assay variation.
Wong
Richard C W
RC
Division of Immunology, Queensland Health Pathology Services, Princess Alexandra and Royal Brisbane Hospitals, Brisbane, Queensland, Australia. richard_wong@health.qld.gov.au
Adelstein
Stephen
S
Gillis
David
D
Favaloro
Emmanuel J
EJ
D017153:Antibodies, Anticardiolipin / Q000097:blood* / Q000235:genetics*; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000175:diagnosis; D001780:Blood Coagulation Tests / Q000379:methods; D002138:Calibration; D002624:Chemistry, Clinical / Q000379:methods*; D019411:Clinical Laboratory Techniques; D017408:Guidelines as Topic; D006405:Hematology / Q000379:methods*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood* / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis; D015203:Reproducibility of Results; D012107:Research Design
D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor