title: Developmental expression of glucokinase in rat hypothalamus.
abstract: Neurons in the hypothalamus sense changes in glucose concentration. Glucokinase (GK), a key enzyme for pancreatic (beta)-cell glucose sensing, was found in both the embryonic and adult hypothalamus. GK activity accounted for approximately 20% of total hexokinase (HK) activity in both embryonic and adult hypothalamus with no activity measured in cortical samples, indicating that glucose sensing in the hypothalamus initiates early in development and precedes the maturation of glucose signaling in liver.
authors.affiliation: Department of Physiology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ 85724, USA.
authors.forename: Vicki L
authors.initials: VL
authors.lastname: Sutherland
authors.forename: Matthew
authors.initials: M
authors.lastname: McReynolds
authors.forename: Linda S
authors.initials: LS
authors.lastname: Tompkins
authors.forename: Heddwen L
authors.initials: HL
authors.lastname: Brooks
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Lynch
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D015152:Blotting, Northern / Q000379:methods; D015139:Blotting, Southern / Q000379:methods; D018076:DNA, Complementary / Q000378:metabolism; D004622:Embryo, Mammalian; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D005941:Glucokinase / Q000235:genetics / Q000378:metabolism*; D005947:Glucose / Q000032:analysis; D006593:Hexokinase / Q000378:metabolism; D007031:Hypothalamus / Q000166:cytology / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D066298:In Vitro Techniques; D016133:Polymerase Chain Reaction / Q000379:methods; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018076:DNA, Complementary; D012333:RNA, Messenger; D006593:Hexokinase; D005941:Glucokinase; D005947:Glucose