Primary progressive aphasia: reversed asymmetry of atrophy and right hemisphere language dominance.
Primary progressive aphasia (PPA) is almost always associated with asymmetrical left hemisphere degeneration. The authors report that right hemisphere atrophy in a patient with PPA was associated with atypical right hemisphere dominance for language. This suggests that neuronal damage in PPA is therefore tightly linked to the underlying anatomy of the language network.
Mesulam
M
M
Cognitive Neurology and Alzheimer's Disease Center and the Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. mmesulam@northwestern.edu
Weintraub
S
S
Parrish
T
T
Gitelman
D
D
D018888:Aphasia, Primary Progressive / Q000473:pathology / Q000503:physiopathology*; D001284:Atrophy; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D004292:Dominance, Cerebral; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000473:pathology / Q000503:physiopathology; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology