Association of PLA2 polymorphism of the ITGB3 gene with early fetal loss.
To study the association between early fetal loss and the presence of the PLA2 polymorphism of the ITGB3 gene we conducted a case-control study on 98 cases (i.e., women in fertile age, who experienced at least one episode of early fetal loss) and 38 healthy controls. PLA2 polymorphism was present in 44.2% of cases and 18.4% of controls, and cases with one (n = 24) event had an odds ratio (OR) = 2.7 (95% confidence interval [CI] 0.7-10.0), with two events (n = 52) an OR = 3.8 (95% CI 1.3-11.5), and with three (n = 16) or four abortions (n = 6) had a combined OR = 4.4 (95% CI 1.2-17.0), compared to controls, indicating that PLA2 polymorphism may be implicated in an inherited form of thrombophilia, and to early fetal loss.
Ruzzi
Laura
L
Clinical Pathology Laboratory, Istituto Dermopatico dell'Immacolata (IDI-IRCCS), Rome, Italy. l.ruzzi@idi.it
Ciarafoni
Iolanda
I
Silvestri
Lorena
L
Semeraro
Maria Letizia
ML
Abeni
Damiano
D
D000022:Abortion, Spontaneous / Q000235:genetics*; D016824:Antigens, Human Platelet / Q000235:genetics*; D005260:Female; D005313:Fetal Death / Q000235:genetics; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011379:Prognosis
D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; C083451:human platelet antigen 1b