title: Latex sensitisation and allergy in children with myelomeningocele.
abstract: BACKGROUND
  Children with spina bifida (SB) have a high degree of exposure to latex products as a consequence of repeated surgical procedures, implantation of latex-containing materials and catheterisation. The consequence is a higher incidence of latex allergic reactions.
  
  
  OBJECTIVE
  The aim of this study is to evaluate the prevalence of latex sensitisation and allergy in a population of children with myelomeningocele (MMC) and to assess the role of associated risk factors.
  
  
  RESULTS
  Forty-eight percent of the patients (29 out of 60) showed a latex sensitisation with specific IgE >0.7 kU/l while 15% (9 out of 60) were allergic to latex (specific IgE >0.7 kU/l and clinical manifestations). The principal factor correlated with allergy to latex was specific serum IgE to latex (radioallergosorbent test [RAST]) values (p<0.01). Other factors were total serum IgE (paper radioimmunosorbent test [PRIST]) values, number of surgical procedures and familiarity with allergy.
  
  
  CONCLUSIONS
  These results underline the importance of prophylactic measures to avoid the exposure, not only in the sanitary environment, through the institution of latex-safe routes, but also in daily life, to prevent potentially serious allergic reactions.
authors.affiliation: Paediatric Department, Spina Bifida Centre, Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy. c.rendeli@libero.it
authors.forename: C
authors.initials: C
authors.lastname: Rendeli
authors.forename: E
authors.initials: E
authors.lastname: Nucera
authors.forename: E
authors.initials: E
authors.lastname: Ausili
authors.forename: F
authors.initials: F
authors.lastname: Tabacco
authors.forename: C
authors.initials: C
authors.lastname: Roncallo
authors.forename: E
authors.initials: E
authors.lastname: Pollastrini
authors.forename: M
authors.initials: M
authors.lastname: Scorzoni
authors.forename: D
authors.initials: D
authors.lastname: Schiavino
authors.forename: M
authors.initials: M
authors.lastname: Caldarelli
authors.forename: D
authors.initials: D
authors.lastname: Pietrini
authors.forename: G
authors.initials: G
authors.lastname: Patriarca
mesh_terms: D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D020315:Latex Hypersensitivity / Q000150:complications* / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008591:Meningomyelocele / Q000453:epidemiology* / Q000209:etiology* / Q000276:immunology; D015995:Prevalence; D012307:Risk Factors; D012882:Skin Tests; D016135:Spinal Dysraphism / Q000453:epidemiology / Q000209:etiology
chemical_list: D000888:Antibodies, Anti-Idiotypic