QT interval prolongation associated with the oral use of domperidone in an infant.
Gastroesophageal reflux is very common in childhood. If conservative procedures fail to relieve it, the use of a potent antiemetic agent that facilitates gastric motility and emptying, such as domperidone, is justified. We report a 4-month-old child who presented with QT interval prolongation after the oral use of domperidone, which normalized after the drug was discontinued.
Rocha
C M G
CM
Ecocenter, Hospital Socor, Belo Horizonte, Minas Gerais, Brazil.
Barbosa
M M
MM
D000932:Antiemetics / Q000009:adverse effects*; D004294:Domperidone / Q000009:adverse effects*; D004562:Electrocardiography; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects
D000932:Antiemetics; D004294:Domperidone