Multifunctional drug delivery system using starch-alginate beads for controlled release.
Utilizing starch-containing alginate beads, a novel drug delivery system (DDS) was developed. With the starch inside, the composite bead could be dried in its original bead shape and handled in the dried state. By employing alginate multi-coating strategy on the starch-alginate beads, detained or controlled release was efficiently achieved and successfully demonstrated for a model peptide drug, L-phenylalanine. The initial latent time and release rate of the drug inside the beads were able to be controlled simply by varying the number of multi-coatings. While the latent time for the initial release was negligible for non-coated starch-alginate beads, the latent times of beads coated one, two, and four times increased to 15, 30, and 70 min, respectively. Furthermore, the alginate component of the composite beads could adsorb and remove heavy metals such as lead from the body. These multifunctional beads combined with the novel coating process will greatly benefit alginate gel-based DDS.
Kim
Young Joo
YJ
National Genome Information Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun-dong, Yuseong-gu, Daejon 305-333, Korea.
Park
Hyun Gyu
HG
Yang
Young Lyul
YL
Yoon
Yoosik
Y
Kim
Sangsoo
S
Oh
Eugene
E
D000464:Alginates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013213:Starch / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000464:Alginates; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D013213:Starch