Migraine headache relief after transcatheter closure of patent foramen ovale.
OBJECTIVE
The purpose of this study was to determine the effects of transcatheter patent foramen ovale (PFO) closure on migraine frequency in patients with paradoxical cerebral embolism.


BACKGROUND
The prevalence of migraine headache is higher in cryptogenic stroke patients with PFO than in the general population. Previous studies have suggested that closure of the PFO may reduce migrainous symptoms.


METHODS
Between April 2001 and December 2003, 162 consecutive patients with paradoxical cerebral embolism underwent transcatheter PFO closure for prevention of recurrent cryptogenic stroke or transient ischemic attack. A one-year retrospective analysis of migraine symptoms before and after PFO closure was performed.


RESULTS
Active migraine was present in 35% (57 of 162) of patients, and 68% (39 of 57) experienced migrainous aura; 50 patients were available for analysis at one year. Complete resolution of migraine symptoms occurred in 56% (28 of 50) of patients, and 14% (7 of 50) of patients reported a significant (>or=50%) reduction in migraine frequency. Patients reported an 80% reduction in the mean number of migraine episodes per month after PFO closure (6.8 +/- 9.6 before closure vs. 1.4 +/- 3.4 after closure, p < 0.001). Results were independent of completeness of PFO closure at one year.


CONCLUSIONS
In patients with paradoxical cerebral embolism, migraine headaches are more frequent than in the general population, and transcatheter closure of the PFO results in complete resolution or marked reduction in frequency of migraine headache.
Reisman
Mark
M
Cardiovascular Research, Swedish Medical Center.
Christofferson
Ryan D
RD
Jesurum
Jill
J
Olsen
John V
JV
Spencer
Merrill P
MP
Krabill
Kimberly A
KA
Diehl
Lance
L
Aurora
Sheena
S
Gray
William A
WA
D006328:Cardiac Catheterization; D019320:Embolism, Paradoxical / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000601:surgery*; D006801:Humans; D020766:Intracranial Embolism / Q000150:complications; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000209:etiology* / Q000601:surgery*; D012189:Retrospective Studies