title: [Comparative investigation of calcium ketopantoylaminobutyrate and pantogam: tranquilizer activity].
abstract: Comparative study of the sedative (calming) properties of the new drug calcium ketopantoylaminobutyrate (Ca-KPAB) and the reference drug pantogam (calcium homopantotenate) showed that the newly synthesized compound produces a more pronounced calming action in several standard neuropharmacological tests (spontaneous motor activity, barbiturate antagonist, etc.) and exhibits some additional advantages. Thus, a slight modification of the chemical structure made possible a significant reduction in the effective drug dose.
authors.forename: A L
authors.initials: AL
authors.lastname: Karaev
authors.forename: G S
authors.initials: GS
authors.lastname: Kozlova
authors.forename: T N
authors.initials: TN
authors.lastname: Smirnova
authors.forename: V I
authors.initials: VI
authors.lastname: Gunar
mesh_terms: D000613:Aminobutyrates / Q000008:administration & dosage*; D000818:Animals; D005260:Female; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D018697:Nootropic Agents / Q000008:administration & dosage*; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000613:Aminobutyrates; D006993:Hypnotics and Sedatives; D018697:Nootropic Agents; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid