[Association of schizophrenia with a promoter polymorphism in the dopamine D2 receptor gene].
OBJECTIVE
To investigate the association of -141C insert/delete polymorphism with schizophrenia in Wuhan of Hubei province.


METHODS
A case-control study was conducted to analyze the polymorphism in the D(2) receptor gene promoter region with schizophrenia. A total of 120 cases of schizophrenia diagnosed according to CCMD-II R criteria and 100 normal controls were recruited in the study.


RESULTS
In this sample, the allele and genotype showed statistically significant differences between patients and normal controls (P<0.05).Especially, the frequency of -141C del was 11% in patients and 18% in control(OR 0.55, 95% CI 0.30-0.96; P<0.05). This allele was less common in schizophrenia than in normal controls (P<0.05).


CONCLUSIONS
The -141C del polymorphism is associated with schizophrenia.The polymorphism may modify the association with other factors. Possibly -141C del in the DRD(2) promoter region is a strong candidate for a protective factor for this trait.
Peng
Dai-hui
DH
Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060 PR China. pengdaihui@21cn.com
Wang
Gao-hua
GH
Cheng
Zi-li
ZL
Zhang
De-xin
DX
Jiang
Kai-da
KD
D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics*
D017448:Receptors, Dopamine D2