[Cross-linked beta-cyclodextrin polymer used for bilirubin removal].
A new material for adsorption of bilirubin was synthesized with cross-linking reaction of beta-cyclodextrin. The kinetic adsorption behaviors of bilirubin such as the effects of temperature, pH, the initial bilirubin concentration as well as bovine seum albumin on the removal of bilirubin have been investigated. It is demonstrated that bilirubin could be adsorbed well on the prepared sorbent quickly and higher temperature favored the adsorpion of bilirubin. The percentage of removal of bilirubin reached 92.6% with initial bilirubin concentration of 40 mg/L in phosphate buffer at pH 7.8. With the increase of initial bilirubin concentration, the percentage of removal of bilirubin decreased; however, the adsorption capacity increased.
Zheng
Chaojun
C
National Chromatographic R. & A. Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116011, China. zhengchaojun@eyou.com
Huang
Xiaodong
X
Kong
Liang
L
Li
Xin
X
Zou
Hanfa
H
D000327:Adsorption; D001663:Bilirubin / Q000097:blood* / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011108:Polymers; D013056:Spectrophotometry, Ultraviolet; D047392:beta-Cyclodextrins / Q000737:chemistry*
D003432:Cross-Linking Reagents; D011108:Polymers; D047392:beta-Cyclodextrins; C031215:betadex; D001663:Bilirubin