["Restricted ablation" of elongated uvula mucosa by the injection of the ethanol/steroid mixture: a new treatment for snoring and OSAS].
We developed a "Submucosal Ethanol/Steroid (E/S) Injection Method (SEIM)" using an injection prepared by dissolving steroid with powerful antiinflammatory effect, which has the excellent effect of contractile reduction in oral tissues. In this clinical trial, the ablation effect of SEIM on the abnormally elongated uvula and the soft palate was examined in each one clinical case of obstructive sleep apnea syndrome (OSAS) and simple snoring. In the OSAS, we found that the uvula was reduced from 15 to 10mm, the visual analog scale (VAS) of snoring was reduced from 10 to 4 points, and the respiration disturbance index of the apnea-hypopnea index (AHI) improved from 35.3 to 26.1 after treatment. In simple snoring, the uvula was reduced from 11 to 8.5mm and VAS was relieved from 7 to 2 points after treatment. Our approach will produce a great clinical significance for not only OSAS or simple snoring but also treatment of the allergic rhinitis, etc, because the contractile tissue reduction can be attained safely in these diseases without open surgical wounds and unnecessary deformation or destruction of the mucosal structure.
Wu
Men-dar
MD
Department of Otorhinolaryngology, Aichi Medical University, Aichi.
Kimura
Masaru
M
Kusumi
Taeko
T
Taguchi
Aiko
A
Nakayama
Meiho
M
Inafuku
Shigeru
S
D000328:Adult; D003907:Dexamethasone / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D004338:Drug Combinations; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa; D020181:Sleep Apnea, Obstructive / Q000188:drug therapy*; D012913:Snoring / Q000188:drug therapy*; D016896:Treatment Outcome; D014609:Uvula
D004338:Drug Combinations; C004180:dexamethasone 21-phosphate; D000431:Ethanol; D003907:Dexamethasone