Testicular growth, sperm concentration, percent motility, and pregnancy outcome after varicocelectomy based on testicular histology.
OBJECTIVE
To evaluate the outcome following surgery in two different patterns of testicular histology in patients with varicocele.


METHODS
Prospective study.


METHODS
Academic medical center.


METHODS
Sixty patients underwent varicocelectomy and had a testicular histology diagnosis of germ-cell aplasia (group I, n = 28) or maturation arrest (group II, n = 32).


METHODS
Varicocelectomy.


METHODS
Preoperative hormone levels, testicular size, and sperm parameters. After varicocelectomy, variations in testicular size, semen parameters, and pregnancy rates were evaluated.


RESULTS
The mean volume of the right and left testicle was smaller in group I patients than in group II. In addition, the mean sperm concentration before treatment was lower in group I than in group II. The mean volume of the left and right testicle increased in group I after the intervention. The mean postoperative sperm concentration and motility in group II showed no increase, whereas the mean sperm concentration in group I did increase. The pregnancy rate was higher in group II (14/26, 53.8%) than in group I (4/16, 25%) (P=.02).


CONCLUSIONS
Patients with germ-cell aplasia present a postoperative increase in testicular size but the pregnancy rate is higher in patients with maturation arrest following surgery.
Pasqualotto
Fábio Firmbach
FF
Divisão de Clínica Urológica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. Fabio@conception-rs.com.br
Lucon
Antônio Marmo
AM
de Góes
Plínio Moreira
PM
Hallak
Jorge
J
Sobreiro
Bernardo
B
Pasqualotto
Eleonora Bedin
EB
Arap
Sami
S
D000328:Adult; D002455:Cell Division; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000473:pathology / Q000601:surgery; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D013081:Sperm Motility; D013091:Spermatogenesis; D013094:Spermatozoa / Q000166:cytology; D013737:Testis / Q000254:growth & development* / Q000473:pathology*; D014646:Varicocele / Q000473:pathology / Q000601:surgery*