title: [Based on the incidence of Creutzfeldt-Jakob disease in the Lanzarote healthcare area. Description of two definitive cases].
abstract: We present two cases who have been diagnosed of definitive Creutzfeldt-Jakob disease in the health area of Lanzarote in the period January 2002 to January 2004. The two cases are presented with clinical description, complementary tests -- including electroencephalogram, 14-3-3 protein determination -- study of the prionic protein gene, and histopathologic findings. In this article, we try to show the importance of trying to reach a definitive diagnosis with the histopathologic study once there is clinical suspicion (a diagnosis that is probable or possible). In addition our cases show that communication between the clinical and the epidemiological coordinator of the regional community and the National Center of Epidemiology is very important. We refer to the clear growth in the incidence of the disease in the population of Lanzarote in the period above mentioned. Finally, we discuss whether this growth is or is not an isolated event.
authors.affiliation: Unidad de Neurología, Servicio de Medicina Interna, Hospital General de Lanzarote, Arrecife, Las Palmas. CHERNAN@telefonica.net
authors.forename: F J
authors.initials: FJ
authors.lastname: Hernández-Ramos
authors.forename: M
authors.initials: M
authors.lastname: Martínez Martín
authors.forename: M
authors.initials: M
authors.lastname: Esteban Robayna
authors.forename: F
authors.initials: F
authors.lastname: Jensen Toll
authors.forename: S
authors.initials: S
authors.lastname: Palacios Llopis
mesh_terms: D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D013030:Spain