Protocol of radiotherapy for glioblastoma according to the expression of HIF-1.
Hypoxia is a common feature of many malignant neoplasms and has been identified as a major reason for the radioresistance of malignant tumor tissue. On the other hand, the transcription factor hypoxia-inducible factor-1 (HIF-1) has attracted attention because it is rapidly expressed when tissue oxygen tension is reduced, thus playing the role of a hypoxic sensor. We investigated whether the level of HIF-1 expression in glioblastoma (GBM) could be an indicator in a protocol for postoperative radiotherapy. We immunohistologically evaluated the level of HIF-1 expression in 60 pathologically diagnosed GBMs. HIF-1 expression was positive in all tumors. The progression-free survival of the group receiving only conventional radiotherapy after surgery differed significantly according to the level of HIF-1 expression. The results of this study suggest that the HIF-1 expression level can be an indicator of tumor radioresistance, and that prior knowledge of the HIF-1 expression level allows the formulation of a protocol for postoperative radiotherapy.
Irie
Nobuyuki
N
Department of Neurosurgery, Nagasaki University Hospital, Nagasaki 852-8501, Japan. nob-irie@net.nagasaki-u.ac.jp
Matsuo
Takayuki
T
Nagata
Izumi
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D024221:Antineoplastic Protocols; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000378:metabolism / Q000401:mortality / Q000532:radiotherapy*; D002648:Child; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D018572:Disease-Free Survival; D005260:Female; D005909:Glioblastoma / Q000378:metabolism / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000096:biosynthesis*; D011379:Prognosis; D014157:Transcription Factors / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C497442:HIF1A protein, human; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D014157:Transcription Factors