title: A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi.
abstract: Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design.
authors.affiliation: Laboratory of Molecular Biophysics, Department of Biochemistry, South Parks Road, Oxford, UK.
authors.forename: Frank S
authors.initials: FS
authors.lastname: Cordes
authors.forename: Pietro
authors.initials: P
authors.lastname: Roversi
authors.forename: Peter
authors.initials: P
authors.lastname: Kraiczy
authors.forename: Markus M
authors.initials: MM
authors.lastname: Simon
authors.forename: Volker
authors.initials: V
authors.lastname: Brade
authors.forename: Oliver
authors.initials: O
authors.lastname: Jahraus
authors.forename: Russell
authors.initials: R
authors.lastname: Wallis
authors.forename: Christine
authors.initials: C
authors.lastname: Skerka
authors.forename: Peter F
authors.initials: PF
authors.lastname: Zipfel
authors.forename: Reinhard
authors.initials: R
authors.lastname: Wallich
authors.forename: Susan M
authors.initials: SM
authors.lastname: Lea
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D001798:Blood Proteins / Q000378:metabolism; D003180:Complement C3b Inactivator Proteins; D017242:Complement Factor H / Q000378:metabolism; D019281:Dimerization; D008193:Lyme Disease / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D017510:Protein Folding; D017433:Protein Structure, Secondary
chemical_list: D001426:Bacterial Proteins; D001798:Blood Proteins; C493495:CFH protein, human; C517621:CFHR1 protein, human; D003180:Complement C3b Inactivator Proteins; D008565:Membrane Proteins; C440651:complement regulator-acquiring surface proteins, Borrelia burgdorferi; D017242:Complement Factor H