Synthesis of water-dispersible fluorescent, radio-opaque, and paramagnetic CdS:Mn/ZnS quantum dots: a multifunctional probe for bioimaging.
Ultra-small (3.1 nm) multifunctional CdS:Mn/ZnS core-shell semiconductor quantum dots (Qdots), which possess fluorescent, radio-opacity, and paramagnetic properties, have been shown here. To demonstrate in vivo bioimaging capability, a rat was administered endovascularly with Qdots conjugated with a TAT peptide. The labeling efficacy of these Qdots was demonstrated on the basis of the histological analysis of the microtome sliced brain tissue, clearly showing that TAT-conjugated Qdots stained brain blood vessels.
Santra
Swadeshmukul
S
Department of Neurological Surgery, University of Florida, P.O. Box 100265, Gainesville, FL 32610, USA. ssantra@erc.ufl.edu
Yang
Heesun
H
Holloway
Paul H
PH
Stanley
Jessie T
JT
Mericle
Robert A
RA
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000098:blood supply / Q000378:metabolism; D019187:Cadmium Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000493:pharmacokinetics; D015696:Gene Products, tat / Q000737:chemistry / Q000493:pharmacokinetics; D008345:Manganese / Q000737:chemistry* / Q000493:pharmacokinetics; D010446:Peptide Fragments / Q000737:chemistry / Q000493:pharmacokinetics; D045663:Quantum Dots; D051381:Rats; D012822:Silicon Dioxide / Q000737:chemistry; D012995:Solubility; D013440:Sulfides / Q000737:chemistry* / Q000493:pharmacokinetics; D014867:Water / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry* / Q000493:pharmacokinetics
D019187:Cadmium Compounds; D003287:Contrast Media; D005456:Fluorescent Dyes; D015696:Gene Products, tat; D010446:Peptide Fragments; D013440:Sulfides; D017967:Zinc Compounds; C034939:cadmium sulfide; D014867:Water; D008345:Manganese; D012822:Silicon Dioxide; C031238:zinc sulfide