Carboxyhemoglobin levels in cirrhotic patients with and without hepatopulmonary syndrome.
OBJECTIVE
Heme oxygenase (HO) catalyzes hemoglobin into bilirubin, iron, and carbon monoxide (CO), a known vasodilator. HO expression and CO production as measured by blood carboxyhemoglobin (COHb) levels increase in experimental hepatopulmonary syndrome (HPS) and contribute to vasodilatation. Whether CO contributes to HPS in humans is unknown. Our aim was to assess if arterial COHb levels are increased in cirrhotic patients with HPS relative to those without HPS.


METHODS
We collected data prospectively in stable nonsmoking outpatients with cirrhosis. Demographic and clinical data and room-air arterial blood gases were collected and analyzed. HPS was diagnosed using established criteria.


RESULTS
A total of 159 patients were studied. HPS was present in 27 (17%) patients. Mean age was 52 +/- 9 years, 54% were men, and hepatitis C and/or alcohol were the most common causes (53%). Fourteen percent were Child-Pugh class A, 53% were Child-Pugh class B, and 33% were Child-Pugh class C. Demographic and clinical features were similar between HPS and non-HPS patients except for the Child-Pugh score, which was lower in patients with HPS. Arterial Pa o 2 levels were lower and the alveolar-arterial oxygen gradient was higher in patients with HPS ( P < .001). COHb levels were increased in HPS relative to non-HPS ( P < .001) and correlated with Pa o 2 ( P < .001) and Aa po 2 ( P < .001) levels.


CONCLUSIONS
COHb levels are increased in cirrhotic patients with HPS and correlate with gas exchange abnormalities. These results are consistent with findings in experimental HPS and suggest that CO may contribute to human HPS.
Arguedas
Miguel R
MR
University of Alabama at Birmingham Liver Center, Birmingham, AL 35294, USA.
Drake
Britt B
BB
Kapoor
Ashwani
A
Fallon
Michael B
MB
D001663:Bilirubin / Q000097:blood; D002248:Carbon Monoxide / Q000097:blood; D002263:Carboxyhemoglobin / Q000378:metabolism*; D005260:Female; D020065:Hepatopulmonary Syndrome / Q000097:blood* / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure
D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D001663:Bilirubin; D010100:Oxygen