Chronic resistive airway loading reduces weight due to low serum IGF-1 in rats.
One of the consequences of chronic resistive airway loading in rats is malfunction in body weight gain post-surgery. The lower body weight of the obstructed animals was not related to lower caloric intake or to the oxygen consumption/food intake ratio. In the current study, we determined whether the retardation in body weight gain was related to impairment of serum insulin-like growth factor-1 (IGF-1) level or due to activation of inflammatory factors 21 weeks post-surgery. During the observation period, the airway-loaded animals (n=8) gained 44% less body weight (P<0.001) compared with controls (n=8) with no apparent effect on skeletal growth, i.e., body, tail and tibia length. Chronic airway-loaded animals had 32.5% lower serum IGF-1 levels (P<0.001) compared to the controls. Interleukin-6 and tumor necrosis factor-alpha levels were below 30 pg/ml in both groups. These data suggest that the weight loss in the chronic airway-loading rats is associated with a decreased IGF-1 level and not to activation of the inflammatory response.
Tarasiuk
Ariel
A
Department of Physiology, Sleep-Wake Disorders Unit, Soroka University Medical Center, PO Box 151, Beer-Sheva 84101, Israel. tarasiuk@bgu.ac.il
Segev
Yael
Y
D000402:Airway Obstruction / Q000378:metabolism* / Q000503:physiopathology*; D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D001835:Body Weight / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D015850:Interleukin-6 / Q000097:blood; D011183:Postoperative Complications; D051381:Rats; D017207:Rats, Sprague-Dawley; D012119:Respiration; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D007334:Insulin-Like Growth Factor I