Design, synthesis and biological evaluation of novel bicyclic beta-lactams as potential antimalarials.
A series of bicyclic N-substituted and unsubstituted beta-lactams were synthesized and evaluated as targeted potential antimalarials. The compounds MNR4 and MNR5 were found to have highest potency against Plasmodium falciparum in vitro.
Nivsarkar
Manisha
M
Process Technology Development Division, Defence R&D Establishment, Jhansi Road, Gwalior 474002, MP, India.
Thavaselvam
D
D
Prasanna
S
S
Sharma
Mamta
M
Kaushik
M P
MP
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification; D013329:Structure-Activity Relationship; D047090:beta-Lactams / Q000138:chemical synthesis / Q000494:pharmacology
D000962:Antimalarials; D001643:Bridged Bicyclo Compounds; D047090:beta-Lactams