Clinical review: Treatment of heat stroke: should dantrolene be considered?
Rapid and efficient cooling is the most important therapeutic objective in patients with heat stroke (HS). This article reviews the mechanism of action and rationale for the use of dantrolene as a potential supportive cooling method in the treatment of HS. Relevant studies were included to support discussion of the role of dantrolene for the treatment of HS. In some studies dantrolene was shown to accelerate cooling rate when administered after the development of exertional HS. Dantrolene was also found to be effective in reducing the extent of HS signs when given as pretreatment in an animal model. Accumulated data do not support the routine use of dantrolene as an adjuvant cooling technique in HS, but administration of this drug in severe cases, or in which no improvement is observed, appears rational. Further trials are needed in order to assess the true effectiveness of dantrolene in HS.
Hadad
Eran
E
Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer, Israel. yoavcs@mac.com
Cohen-Sivan
Yoav
Y
Heled
Yuval
Y
Epstein
Yoram
Y
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003620:Dantrolene / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000628:therapy; D006207:Half-Life; D018883:Heat Stroke / Q000188:drug therapy* / Q000628:therapy; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D009125:Muscle Relaxants, Central / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*
D009125:Muscle Relaxants, Central; D003620:Dantrolene