Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors.
A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA.
Chen
Bin
B
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA.
Petukhov
Pavel A
PA
Jung
Mira
M
Velena
Alfredo
A
Eliseeva
Elena
E
Dritschilo
Anatoly
A
Kozikowski
Alan P
AP
D000081:Acetamides / Q000737:chemistry* / Q000494:pharmacology*; D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000494:pharmacology
D000081:Acetamides; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D013438:Sulfhydryl Compounds