title: Synthesis and characterization of thiomers of polyaspartamide type.
abstract: Synthesis of poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)]-thioglycolic acid (PHEA-TGA) conjugate as a new polyaspartamide thiomer is described. The parent polymer PHEA is chemically modified by introducing sulphydryl-bearing compound thioglycolic acid. By varying the reaction conditions several batches of PHEA-TGA conjugates were prepared and analyzed. Tensile studies revealed that total work of adhesion of PHEA-TGA increased more than twice compared to the unmodified polymer. Microparticles prepared from the thiolated polymer preserved its bioadhesive properties.
authors.affiliation: PLIVA-Research Institute, Ltd., Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia.
authors.forename: M Bubenik
authors.initials: MB
authors.lastname: Bilicić
authors.forename: J
authors.initials: J
authors.lastname: Filipović-Grcić
authors.forename: A
authors.initials: A
authors.lastname: Martinac
authors.forename: M
authors.initials: M
authors.lastname: Barbarić
authors.forename: B
authors.initials: B
authors.lastname: Zorc
authors.forename: B
authors.initials: B
authors.lastname: Cetina-Cizmek
authors.forename: P
authors.initials: P
authors.lastname: Tudja
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D010316:Particle Size; D010455:Peptides / Q000032:analysis / Q000138:chemical synthesis*; D011108:Polymers / Q000032:analysis / Q000138:chemical synthesis*; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods; D013864:Thioglycolates / Q000032:analysis / Q000138:chemical synthesis*
chemical_list: D010455:Peptides; D011108:Polymers; D013864:Thioglycolates; C008965:alpha,beta-poly((2-hydroxyethyl)-aspartamide)