Rephrasing anaphase: separase FEARs shugoshin.
Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic model has recently been extended by exciting discoveries on three levels: regulation of anaphase by posttranslational modifications and the cohesin protector shugoshin; non-proteolytic roles of separase; and cohesin-independent linkage of sister chromatids.
Stemmann
Olaf
O
Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany. stemmann@biochem.mpg.de
Boos
Dominik
D
Gorr
Ingo H
IH
D000705:Anaphase / Q000502:physiology*; D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology*; D002842:Chromatids / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology*; D010450:Endopeptidases / Q000502:physiology*; D006801:Humans; D010766:Phosphorylation; D025842:SUMO-1 Protein / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology; D064247:Separase
D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; C496644:SGO1 protein, human; D025842:SUMO-1 Protein; D029701:Saccharomyces cerevisiae Proteins; D010450:Endopeptidases; C577986:ESP1 protein, S cerevisiae; C577987:ESPL1 protein, human; D064247:Separase