title: Drug-sensitivity profile of clinical Mycobacterium tuberculosis isolates--a retrospective study from a chest-disease institute in India.
abstract: Multi-drug-resistant tuberculosis (MDR-TB) is a major public-health problem, because treatment is complicated and patients remain infectious for months or years, despite receiving the best available therapy. To gain better understanding of MDR-TB, a retrospective study was initiated to determine the level of drug resistance among patients in a chest-disease institute in India. Two hundred and sixty-three isolates from treatment-failure pulmonary tuberculosis patients (20-70 years) were studied. Drug-sensitivity testing was performed by the modified-proportion method. First- and second-line drugs, along with two quinolone drugs (ofloxacin and ciprofloxacin), were tested. Patients included in this study did not improve with therapy; however, 151 isolates (57.5 %) were susceptible to all four first-line antituberculosis drugs. This study reports low resistance to fluoroquinolones among the strains present in these patients.
authors.affiliation: Department of Microbiology, VP Chest Institute, University of Delhi, Delhi 110 007, India.
authors.forename: T
authors.initials: T
authors.lastname: Dam
authors.affiliation: Department of Microbiology, VP Chest Institute, University of Delhi, Delhi 110 007, India.
authors.forename: M
authors.initials: M
authors.lastname: Isa
authors.affiliation: Department of Microbiology, VP Chest Institute, University of Delhi, Delhi 110 007, India.
authors.forename: M
authors.initials: M
authors.lastname: Bose
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007194:India; D007538:Isoniazid / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D015242:Ofloxacin / Q000494:pharmacology; D012189:Retrospective Studies; D012293:Rifampin / Q000494:pharmacology; D013183:Sputum / Q000382:microbiology; D017211:Treatment Failure; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D002939:Ciprofloxacin; D015242:Ofloxacin; D007538:Isoniazid; D012293:Rifampin