High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania.
Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.
Blomberg
Bjørn
B
Centre for International Health, University of Bergen, N-5021 Bergen, Norway. bjorn.blomberg@cih.uib.no
Jureen
Roland
R
Manji
Karim P
KP
Tamim
Bushir S
BS
Mwakagile
Davis S M
DS
Urassa
Willy K
WK
Fataki
Maulidi
M
Msangi
Viola
V
Tellevik
Marit G
MG
Maselle
Samwel Y
SY
Langeland
Nina
N
D016470:Bacteremia / Q000382:microbiology / Q000401:mortality*; D002675:Child, Preschool; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000472:pathogenicity; D004756:Enterobacteriaceae Infections / Q000382:microbiology / Q000401:mortality*; D004926:Escherichia coli / Q000201:enzymology / Q000472:pathogenicity; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000472:pathogenicity; D008297:Male; D019779:Salmonella enterica / Q000145:classification / Q000201:enzymology / Q000472:pathogenicity; D013636:Tanzania / Q000453:epidemiology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
C107198:beta-lactamase SHV-12; D001618:beta-Lactamases