A practical synthesis of Nalpha-Fmoc-L-pyrazinylalanine via Schöllkopf's chiral auxiliary.
A practical, gram-scale synthesis of L-pyrazinylalanine (Paa) is described, utilizing Schöllkopf's D-valine-derived bis-lactim ether chiral auxiliary.
Neelamkavil
S
S
Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mowery
B P
BP
Thornton
E R
ER
Smith
A B
AB
Hirschmann
R
R
D000409:Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
C501756:N-(9-fluorenylmethoxycarbonyl)pyrazinylalanine; D011719:Pyrazines; D000409:Alanine