title: Use of serum inhibin B levels at the start of ovarian stimulation and at oocyte pickup in the prediction of assisted reproduction treatment outcome.
abstract: OBJECTIVE
  To assess whether serum inhibin B levels before gonadotropin administration and at oocyte pickup (OPU) are associated with pregnancy.
  
  
  METHODS
  Retrospective case-control study.
  
  
  METHODS
  University-based IVF program.
  
  
  METHODS
  Fifty-five IVF pregnancies and 55 control cycles matched by age, type of infertility, E(2) at ovulation induction, number of oocytes retrieved, and number of embryos replaced.
  
  
  METHODS
  None.
  
  
  METHODS
  Association between serum inhibin B at stimulation day 1 (SD1) and OPU and pregnancy; correlation between inhibin B with clinical and endocrine parameters; predictive accuracy of inhibin B measurements at OPU.
  
  
  RESULTS
  Inhibin B on SD1 was similar between pregnant and nonpregnant subjects, whereas it was significantly higher at OPU in pregnant cycles, but did not allow differentiation between pregnancy outcomes. Inhibin B on SD1 was positively correlated with same-day E(2) in both groups and inversely with age in pregnant cycles. In both groups, inhibin B at OPU correlated positively with number of oocytes collected and with E(2) at ovulation induction.
  
  
  CONCLUSIONS
  Higher inhibin B concentrations at OPU are predictive of clinical pregnancy, independently of age, peak E(2), number of oocytes retrieved and number of embryos replaced. Inhibin B on stimulation day 1 did not prove to be a useful predictor.
authors.affiliation: First Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, Budapest, Hungary. urbjan@noi1.sote.hu
authors.forename: János
authors.initials: J
authors.lastname: Urbancsek
authors.forename: Erik
authors.initials: E
authors.lastname: Hauzman
authors.forename: Klaus
authors.initials: K
authors.lastname: Klinga
authors.forename: Thomas
authors.initials: T
authors.lastname: Rabe
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Papp
authors.forename: Thomas
authors.initials: T
authors.lastname: Strowitzki
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007265:Inhibins / Q000097:blood*; D009865:Oocytes; D010062:Ovulation Induction; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: C422364:inhibin B; D007265:Inhibins