Leukocyte adhesion: what's the catch?
A recent study shows that the leukocyte adhesion molecules known as selectins form 'catch' bonds, the dissociation rate of which decreases with increasing applied force. The ability of selectins to switch between catch and slip bonds, where dissociation increases with force, can explain the shear threshold effect, in which leukocyte adhesion goes through a maximum with increasing shear rate.
Hammer
Daniel A
DA
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. hammer@seas.upenn.edu
D002448:Cell Adhesion / Q000502:physiology*; D007962:Leukocytes / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000378:metabolism; D008863:Microspheres; D008954:Models, Biological; D009844:Oligosaccharides / Q000378:metabolism; D011485:Protein Binding; D019087:Selectins / Q000378:metabolism* / Q000502:physiology; D033081:Shear Strength; D000080506:Sialyl Lewis X Antigen; D013379:Substrate Specificity
D008562:Membrane Glycoproteins; D009844:Oligosaccharides; C084882:P-selectin ligand protein; D019087:Selectins; D000080506:Sialyl Lewis X Antigen