title: Gastrointestinal stromal tumor of the prostate.
abstract: We present a unique case of an atypical prostate tumor in a 49-year-old man with acute urinary retention. Digital rectal examination revealed a large prostate with a parenchymal mass on the left side. Radiologic imaging showed a 14.2 x 9.6 x 14.0-cm prostatic mass and multiple liver metastases. A pathologic diagnosis of a prostatic gastrointestinal stromal tumor was made and was confirmed by molecular analysis. Therapy consisted of a tyrosine kinase inhibitor, resulting in prostate mass reduction. After 100 weeks, the patient was in good physical condition with a continuing partial response with a reduced mass volume and liver nodules.
authors.affiliation: Department of Urology, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium.
authors.forename: Frank
authors.initials: F
authors.lastname: Van der Aa
authors.forename: Raf
authors.initials: R
authors.lastname: Sciot
authors.forename: Wim
authors.initials: W
authors.lastname: Blyweert
authors.forename: Dieter
authors.initials: D
authors.lastname: Ost
authors.forename: Hendrik
authors.initials: H
authors.lastname: Van Poppel
authors.forename: Allan
authors.initials: A
authors.lastname: Van Oosterom
authors.forename: Maria
authors.initials: M
authors.lastname: Debiec-Rychter
authors.forename: Dirk
authors.initials: D
authors.lastname: De Ridder
mesh_terms: D000208:Acute Disease; D019943:Amino Acid Substitution; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D006801:Humans; D000068877:Imatinib Mesylate; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D009363:Neoplasm Proteins / Q000235:genetics; D010879:Piperazines / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D011743:Pyrimidines / Q000627:therapeutic use; D011859:Radiography; D012509:Sarcoma / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics / Q000556:secondary; D016055:Urinary Retention / Q000209:etiology; D015431:Weight Loss
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D009363:Neoplasm Proteins; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit