Molecular mechanisms of hormonal activity. I. Receptors. Neuromediators. Systems with second messengers.
Hormone signal transfer along all of the cell compartments including nucleus is powered by signal transduction systems. Characteristics and importance of hormone receptors, principal components, functional mechanisms, and biological role of different systems with second messengers are described. Considerable examples of the importance of these systems for medicine are adduced. The drugs modifying these systems comprise more than 65% of contemporary medicines.
Kulinsky
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Department of Biochemistry, Irkutsk State Medical University, Irkutsk 664003, Russia. kulinsky@pp.irkutsk.ru
Kolesnichenko
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LS
D000818:Animals; D006152:Cyclic GMP / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D006801:Humans; D011956:Receptors, Cell Surface / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology*
D006728:Hormones; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D017981:Receptors, Neurotransmitter; D019204:GTP-Binding Proteins; D006152:Cyclic GMP