Use of lomustine to treat cutaneous nonepitheliotropic lymphoma in a cat.
A 17-year-old spayed female domestic shorthair cat was referred for evaluation of severe skin lesions, including ulceration, nodule formation, erythema, and alopecia. Cutaneous nonepitheliotropic lymphoma was diagnosed histologically. There was no evidence of visceral organ involvement, but renal function was decreased. The cat was treated with lomustine (45.5 mg/m2, PO, q 21 d), and skin lesions resolved after administration of the third dose. No severe toxicoses were identified. Results suggest that lomustine may be useful for treatment of cutaneous nonepitheliotropic lymphoma in cats; however, optimal dosage, efficacy, and potential adverse effects must be determined.
Komori
Shinobu
S
Nippon Veterinary and Animal Science University, 1-7-1 Kyounan-cho, Musashino-shi, Tokyo, 180-8602, Japan.
Nakamura
Shinichiro
S
Takahashi
Kimimasa
K
Tagawa
Masahiro
M
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy* / Q000473:pathology; D002415:Cats; D017809:Fatal Outcome; D005260:Female; D008130:Lomustine / Q000627:therapeutic use*; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011379:Prognosis; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
D018906:Antineoplastic Agents, Alkylating; D008130:Lomustine