[Study on expression of matrix metalloproteinases and their inhibitors in parotid gland tumors].
OBJECTIVE
To explore the correlation of MMP and TIMP and clinical data in benign and malignant parotid tumors.


METHODS
The expression of matrix metalloproteinase-2, -9 (MMP-2, MMP-9), tissue inhibitor-1, 2 of matrix metalloproteinase (TIMP-1,TIMP-2) were determined in 60 patients with benign and malignant parotid gland tumors by ABC immunohistochemical methods, their correlation of clinical data was analysed.


RESULTS
(1) Down-regulation of TIMP-2 was accompanied by lymph node metastasis and distant metastasis in malignant parotid tumor (P<0.01). (2) The expression of MMP-2 was higher in patients more than 60 years old in benign parotid tumor (P<0.01). (3) There was a close positive relationship between the expression of MMP-2 and MMP-9, MMP-9 and TIMP-1, MMP-2 and TIMP-2 (P<0.05).


CONCLUSIONS
The imbalance of MMP-2 and TIMP-2 may be more important in malignant parotid gland tumor, down-expression of TIMP-2 may be an early biomarker of metastasis and invasion of tumor.
Xu
Yaping
Y
Department of Otorhinolaryngology, the Second Hospital Affiliated Medical College of Zhejiang University, Hangzhou, 310009, China.
Chen
Ming
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010307:Parotid Neoplasms / Q000378:metabolism* / Q000473:pathology; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000096:biosynthesis; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000096:biosynthesis*
D019715:Tissue Inhibitor of Metalloproteinase-1; D019716:Tissue Inhibitor of Metalloproteinase-2; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9