New sphingolipids and a sterol from a lobophytum species of the Indian ocean.
Chemical investigation of a soft coral species of the genus Lobophytum has resulted in the isolation of three new sphingolipids--(2S,3S,4R)-2-nonadecanoylamino-octadecane-1,3,4-triol (1), (2S,3R,4E,8E)-[(2'R)-2'-hydroxyheptadecanoylamino]-4,8-octadecadiene-1,3-diol (2), 1-O-(beta-D-glucopyranosyl)-(2S,3R,4E,8E)-2-[(2'R)-2'-hydroxynonadecanoylamino]-9-methyl-4,8-octadecadiene-1,3-diol (3) and a sterol--(24S)-ergost-5-en-3beta,7beta-diol (4) along with the known sphingolipid--(2S,3R,4E,8E)-2-hexadecanoylamino-4,8-octadecadien-1,3-diol (5) which showed cytotoxicity against human peripheral blood mononuclear cells (PBMC).
Muralidhar
Pendyala
P
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India.
Kumar
Muthyala Muralikrishna
MM
Krishna
Nallamothu
N
Rao
Chaganty Bheemasankara
CB
Rao
Desaraju Venkata
DV
D000107:Acetylation; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002853:Chromatography, Liquid; D008401:Gas Chromatography-Mass Spectrometry; D019156:Indian Ocean; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000432:Methanol; D012997:Solvents; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013107:Sphingolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D008387:Marine Toxins; D012997:Solvents; D013107:Sphingolipids; D013261:Sterols; D000432:Methanol