Dynamics of the self-assembly of unilamellar vesicles.
We have studied the transient stages in the formation of unilamellar vesicles with millisecond time resolution. The self-assembly was initiated by rapid mixing of equimolar amounts of anionic and zwitterionic micelles and the transient micellar entities were probed by time-resolved small-angle x-ray scattering. Within the mixing time, original micelles transformed to disklike micelles which evolved further to a critical size and then closed to form monodisperse unilamellar vesicles within a second. Subsequent growth led to an unexpected broadening of the vesicle size distribution.
Weiss
T M
TM
European Synchrotron Radiation Facility, BP 220, F-38043 Grenoble Cedex, France.
Narayanan
T
T
Wolf
C
C
Gradzielski
M
M
Panine
P
P
Finet
S
S
Helsby
W I
WI
D003460:Crystallization / Q000379:methods*; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008560:Membrane Fluidity; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D010316:Particle Size; D012996:Solutions
D008051:Lipid Bilayers; D008081:Liposomes; D046911:Macromolecular Substances; D012996:Solutions