title: Aneurysmal subarachnoid hemorrhage: management strategies and clinical outcomes in a regional neuroscience center.
abstract: OBJECTIVE
  Aneurysmal subarachnoid hemorrhage (SAH) affects six to eight people per 100,000 annually, yet the optimum management of this condition remains controversial. Although the International Subarachnoid Aneurysm Trial (ISAT) explored this area, only 28% of patients from our center were randomized in that study. Our purpose was to evaluate the treatment and outcomes of patients not recruited into ISAT.
  
  
  METHODS
  Procedural data, adverse events, additional procedures, and length of hospital stay were recorded for 122 patients who came to our center with aneurysmal SAH. Modified Rankin Scale (MRS) was assessed at 2 months and at 1 year by a postal questionnaire and telephone interview.
  
  
  RESULTS
  Nine patients were treated conservatively, 67 underwent surgical clipping, and 46 underwent endovascular therapy. At 2 months, a good grade (MRS 0-2) was achieved in 67% of patients treated with endovascular therapy and in 45% of patients treated with surgery. At 1 year, a good grade was achieved in 72% in the endovascular group and 49% in the surgical group.
  
  
  CONCLUSIONS
  Endovascular therapy was a safe and effective treatment in a series of subjects who were not randomized in ISAT and in whom endovascular therapy was chosen over surgical clipping. The outcomes at 2 months and 1 year for those subjects treated with endovascular therapy were superior to the outcomes in those treated with surgical clipping. Our study was small and from a single center, but in this population the outcomes of endovascular treatment were similar to those reported by ISAT.
authors.affiliation: Neuroradiology Department, Regional Neurosciences Centre, Newcastle Hospitals NHS Trust, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, England.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Flett
authors.forename: Colin S
authors.initials: CS
authors.lastname: Chandler
authors.forename: David
authors.initials: D
authors.lastname: Giddings
authors.forename: Anil
authors.initials: A
authors.lastname: Gholkar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000628:therapy*; D016896:Treatment Outcome