Synthesis and schistosomicidal activity of new substituted thioxo-imidazolidine compounds.
Synthesis and physico-chemical properties of 3-benzyl-5-(4-fluoro-benzylidene)-1-methyl-2-thioxo-imidazolidin-4-ones, 5-benzylidene-3-(4-nitro-benzyl)-2-thioxo-imidazolidin-4-ones and 4-acridin-9-ylmethylene-1-benzyl-5-thioxo-imidazolidin-2-ones compounds are described. These thioxo-imidazolidine derivatives were prepared by alkylation and condensation with 4-fluoro-benzaldehyde or nucleophilic Michael addition with cyanoacrylates. The schistosomicidal activity of 3-benzyl-5-(4-fluoro-benzylidene)-1-methyl-2-thioxo-imidazolidin-4-one compounds was evaluated.
Albuquerque
M C P A
MC
Laboratorio de Imunopatologia Keizo Asami - LIKA, Centro de Ciências Biológicas, Universidade Federal de Pernambuco - UFPE, Recife, Brasil.
Silva
T G
TG
Pitta
M G R
MG
Silva
A C A
AC
Silva
P G
PG
Malagueño
E
E
Santana
J V
JV
Wanderley
A G
AG
Lima
M C A
MC
Galdino
S L
SL
Barbe
J
J
Pitta
I R
IR
D000818:Animals; D018360:Crystallography, X-Ray; D005260:Female; D048289:Imidazolidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D012550:Schistosoma mansoni / Q000187:drug effects; D012556:Schistosomicides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
D048289:Imidazolidines; D007202:Indicators and Reagents; D012556:Schistosomicides