[Evaluation of oxidative stress and enzymatic antioxidants in medium physical training of moderate arterial hypertension].
A group of patients with moderate hypertension (149-150/90-99 mmHg) performed physical exercise for 3 months; we determined the oxidative stress in blood samples, by calculating the level of some antioxidative markers, the enzymes SOD, CAT, GPx, MDA and comparing the results with the values obtained from a group of healthy subjects. We found an increased oxidative stress at the hypertensive patients, with initial higher values of SOD and MDA and with lower values of CAT and GPx, compared to the normal subjects. After the 3 months of physical training, the oxidative stress improved, with decreasing activity of SOD, GPx, MDA and increasing CAT, maintaining the ratio CAT/SOD and GPx/SOD superior compared to normal subjects. The clinical study proved that after 3 months of physical exercise, there wasn't any increased oxidative stress at the hypertensive patients; however, the oxidative stress is present, proved by the values of MDA, significantly higher compared to the normal subjects.
Chiriac
Silvia
S
Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină, Clinica a VI-a Medicală, Spitalul Clinic de Recuperare Iaşi.
Jerca
Luminiţa
L
Ungureanu
Didona
D
Dima-Cozma
Corina
C
Jerca
Oltiţa
O
Iacobovici
Anica
A
Popovici
Irina
I
Gheorghiţă
Nastasia
N
Pandele
G I
GI
D000465:Algorithms; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D015444:Exercise; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000201:enzymology / Q000628:therapy*; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase