Does nitric oxide play a role in maternal tolerance towards the foetus?
In pregnancy there occurs maternal tolerance to the foetus. Several mechanisms have been proposed to explain this phenomenon. The main immune population in the decidua are macrophages and natural killer cells, but with some "special" suppressor characteristics. There is also a predominant TH2 response. The non classical MCH type I HLA-G is expressed by trophoblasts and can suppress lymphomononuclear cytotoxicity. Other system to avoid the immune system is the expression of indoleamine-2,3-dioxygenase, that suppresses T cell activation by degrading tryptophan. Even though in the placenta there is a high production of nitric oxide, a well-known immune modulator, low attention has been paid to its role in maternal tolerance. There are many data showing that NO affects the IDO, CD95/CD95-L and the balance between TH1/TH2. Maybe NO could interact with several mechanisms at the same time, which could modify the tolerogenic activity depending on the concentration and the presence of other factors in the medium.
González
A
A
Department of Clinical Biochemistry, University of Navarra, Spain. agonzaleh@unav.es
López
A S
AS
Alegre
E
E
Alcázar
J L
JL
López-Moratalla
N
N
D003656:Decidua / Q000166:cytology / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000096:biosynthesis; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology* / Q000502:physiology*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D009569:Nitric Oxide / Q000502:physiology*; D011247:Pregnancy / Q000276:immunology*; D014327:Trophoblasts / Q000276:immunology; D014366:Tryptophan Oxygenase / Q000378:metabolism; D019014:fas Receptor / Q000502:physiology
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D019014:fas Receptor; D009569:Nitric Oxide; D014366:Tryptophan Oxygenase