Cell size control: new evidence for a general mechanism.
Continuously proliferating cells have to precisely double their size during each cycle to maintain constant volumes. Time and again, this fact raised questions on the existence of an active cell size control mechanism in eukaryotic cells, which would prevent delayed or premature cell division at inadequate mass. We addressed this open issue by recapitulating in animal cells several long-standing experiments which had identified such a mechanism in yeast.
Grebien
Florian
F
Max F. Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria.
Dolznig
Helmut
H
Beug
Hartmut
H
Mullner
Ernst W
EW
D000818:Animals; D003585:Cell Biology; D002453:Cell Cycle; D018797:Cell Cycle Proteins; D002455:Cell Division; D002468:Cell Physiological Phenomena; D049109:Cell Proliferation; D048429:Cell Size; D016213:Cyclins; D004271:DNA, Fungal; D016193:G1 Phase; D005821:Genetic Techniques; D016681:Genome, Fungal; D006801:Humans; D012441:Saccharomyces cerevisiae / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins
D018797:Cell Cycle Proteins; D016213:Cyclins; D004271:DNA, Fungal; D029701:Saccharomyces cerevisiae Proteins