title: Outcome of patients with multiple myeloma and hypertension treated with angiotensin-I-converting enzyme inhibitors during high-dose chemotherapy.
abstract: In a retrospective study we have sought to determine whether the administration of angiotensin-I-converting enzyme inhibitors (ACEI) influences the outcome of patients with multiple myeloma (MM). Patients with MM who underwent autologous peripheral blood stem cell transplantation (PBSCT) (n=168) were studied. Patients taking ACEI alone or in combination with other antihypertensive agents during the hospital admission for PBSCT were allocated to the ACEI group (n=25; 15%). Patients from the non-ACEI group (n=143; 85%) were taking other or no antihypertensive medication. Patients taking ACEI had worse overall survival (OS) compared to patients not taking ACEI (38.7 versus 73.3 months after diagnosis; P=0.025). Among patients with hypertension, both OS and progression-free survival were significantly shorter in patients taking ACEI. There were no significant differences between the studied groups in standard prognostic parameters for MM (age, albumin, beta 2-microglobulin, IPI and Durie-Salmon stage, LDH, CRP, performance status) or in engraftment. The mortality in our study has been mostly myeloma related. In conclusion, according to our findings, ACEI administered during PBSCT have adverse effect on survival of patients with MM.
authors.affiliation: Department of Internal Medicine-Hematooncology, Masaryk University Hospital, Czech Republic. tomas.buchler@imm.ox.ac.uk
authors.forename: Tomas
authors.initials: T
authors.lastname: Buchler
authors.forename: Marta
authors.initials: M
authors.lastname: Krejci
authors.forename: Adam
authors.initials: A
authors.lastname: Svobodnik
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Adam
authors.forename: Jiri
authors.initials: J
authors.lastname: Minarik
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Bacovsky
authors.forename: Vlastimil
authors.initials: V
authors.lastname: Scudla
authors.forename: Jiri
authors.initials: J
authors.lastname: Mayer
authors.forename: Jiri
authors.initials: J
authors.lastname: Vorlicek
authors.forename: Roman
authors.initials: R
authors.lastname: Hajek
mesh_terms: D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D012189:Retrospective Studies; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents