[The effect of recombinant interleukin 1beta on cytochrome P-450 dependent monooxygenases in rat liver and kidney].
Effects of a single administration of the human recombinant interleukin 1beta (rIL-1beta, betaleukin) on the cytochrome P-450 dependent monooxygenase activity in rat liver and kidney were evaluated in intact rats and on the background of cytochrome P-450 inductors. It was found that betaleukin suppressed the CYP1A1/2-dependent ethoxyresorufin-o-deethylase activity in both liver and kidney, as well as the CYP2C-dependent dibenzylfluorescein-debenzylase and CYP2E1-dependent nitrophenol-hydroxylase activity in liver, but induced CYP3A-dependent N-demethylation of erythromycin in liver and kidney. Betaleukin also inhibited the beta-naphthoflavone-induced monooxygenase activity in liver, while only insignificantly acted upon the induced monooxygenases in kidney. Betaleukin decreased the pyridine-induced CYP2E1-dependent monooxygenation in liver and CYP1A1/2-dependent monooxygenation in kidney. Therefore, the character and direction of the influence of rIL-1beta on cytochrome P450 belonging to various subfamilies are variable and tissue-specific.
Akhmatov
A T
AT
Sibiriak
S V
SV
Cimbirtsev
A S
AS
Sibiriak
D S
DS
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects*; D006801:Humans; D007375:Interleukin-1 / Q000008:administration & dosage*; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009928:Organ Specificity / Q000187:drug effects; D051381:Rats; D011994:Recombinant Proteins / Q000008:administration & dosage
D007375:Interleukin-1; D011994:Recombinant Proteins; C400322:cytochrome P-450 CYP2C subfamily; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases