title: Time-frequency analysis of the surface electrocardiogram for monitoring antiarrhythmic drug effects in atrial fibrillation.
abstract: This study explored time-frequency analysis of surface electrocardiograms in patients with persistent atrial fibrillation for monitoring atrial drug action. Drug loading over 3 days with oral flecainide (n = 13) or amiodarone (n = 17) organized the fibrillatory process expressed by decreased atrial fibrillatory rate, increased rate stability, and decreased exponential decay. Effects were more pronounced with flecainide than with amiodarone.
authors.affiliation: Department of Cardiology, University Hospital Magdeburg, Magdeburg, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Husser
authors.forename: Martin
authors.initials: M
authors.lastname: Stridh
authors.forename: Leif
authors.initials: L
authors.lastname: Sornmo
authors.forename: Christoph
authors.initials: C
authors.lastname: Geller
authors.forename: Helmut U
authors.initials: HU
authors.lastname: Klein
authors.forename: S Bertil
authors.initials: SB
authors.lastname: Olsson
authors.forename: Andreas
authors.initials: A
authors.lastname: Bollmann
mesh_terms: D000284:Administration, Oral; D000638:Amiodarone / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D016903:Drug Monitoring / Q000379:methods*; D004562:Electrocardiography; D005260:Female; D005424:Flecainide / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000889:Anti-Arrhythmia Agents; D005424:Flecainide; D000638:Amiodarone