title: [p53 gene codon 72 polymorphism and susceptibility to keloid in Chinese population].
abstract: OBJECTIVE
  To investigate the relationship between p53 codon 72 polymorphism and susceptibility to keloid.
  
  
  METHODS
  The p53 genotypes were detected by polymerase chain reaction-reverse dot blot (PCR-RDB) and DNA direct sequencing among 15 healthy controls and 15 patients with keloid.
  
  
  RESULTS
  The frequency of the Pro allele (P = 0.035) and Pro/Pro genotype (P = 0.030) in patients was significantly higher than that in the controls. There was no significant difference in the frequency of Pro/Arg and Arg/Arg genotypes between patients and controls.
  
  
  CONCLUSIONS
  The p53 gene codon 72 polymorphism may play a role in susceptibility to keloid.
authors.affiliation: Department of Plastic Surgery, Nanfang Hospital, Southern Medical University (the First Military Medical University), Guangzhou Guangdong 510515, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhuo
authors.forename: Jianhua
authors.initials: J
authors.lastname: Gao
authors.forename: Shenqiu
authors.initials: S
authors.lastname: Luo
authors.forename: Weisen
authors.initials: W
authors.lastname: Zeng
authors.forename: Zhiqi
authors.initials: Z
authors.lastname: Hu
authors.forename: Feng
authors.initials: F
authors.lastname: Lu
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000483:Alleles; D001120:Arginine / Q000235:genetics; D044466:Asian People / Q000235:genetics; D002681:China; D003062:Codon / Q000235:genetics; D005091:Exons / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007627:Keloid / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D011392:Proline / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53; D001120:Arginine; D011392:Proline