Comparison of the effects of damage to the perirhinal and parahippocampal cortex on transverse patterning and location memory in rhesus macaques.
Monkeys with damage to the parahippocampal (TH/TF) or perirhinal (PRh) cortex were tested on two sets of the transverse patterning (TP) problem (A+/B-, B+/C-, C+/A- and D+/E-, E+/F-, F+/D-) and delayed nonmatching-to-location paradigm (DNML), with delays ranging from 10 to 600 s. Damage to either area impaired acquisition and performance of TP but not of linear discriminations (e.g., A>B>C>X). Damage to areas TH/TF impaired performance of the DNML at all delays but only affected memory for objects at the longest delay, as measured by a delayed nonmatching-to-sample task (DNMS) (Nemanic et al., 2004). Damage to the PRh impaired performance of the DNMS but not of the DNML. The results present a dissociation in object and place memory for these two cortical regions and suggest a role for each in the cortical circuitry supporting configural/relational memory.
Alvarado
Maria C
MC
Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. malvara@emory.edu
Bachevalier
Jocelyne
J
D000818:Animals; D001931:Brain Mapping; D004192:Discrimination, Psychological; D005260:Female; D008253:Macaca mulatta; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000503:physiopathology; D009928:Organ Specificity; D020534:Parahippocampal Gyrus / Q000293:injuries* / Q000503:physiopathology; D010364:Pattern Recognition, Visual / Q000502:physiology*; D011597:Psychomotor Performance; D013037:Spatial Behavior / Q000502:physiology*; D013702:Temporal Lobe / Q000293:injuries* / Q000503:physiopathology