Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-amino-3, 3-diarylpropionic acids.
A series of optically pure, conformationally constrained, and highly hydrophobic unusual aromatic amino acids, 2-amino-3,3-diarylpropionic acids, were synthesized via asymmetric 1,4-Michael addition reaction/azidation reactions in seven steps with overall yields of 20-30%.
Lin
J
J
Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA.
Liao
S
S
Hruby
V J
VJ
D000586:Amination; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008968:Molecular Conformation; D015394:Molecular Structure; D011422:Propionates / Q000737:chemistry*
D000596:Amino Acids; D011422:Propionates; C029658:propionic acid