title: Surgical repair of post infarction ventricular septal defects: a national experience.
abstract: OBJECTIVE
  Ventricular septal rupture is a rare but feared complication after acute myocardial infarction. Most reports about outcome after surgical treatment are single center experiences. We investigated the results after surgical repair in all patients in Sweden during a 7-year period.
  
  
  METHODS
  All patients undergoing surgical repair 1992-1998 were identified with the aid of the Swedish Heart Surgery Registry. The patients (n=189, 63% men, mean age 69+/-8 years) were operated at 10 different centers. Pre-and peri-operative variables were collected from the Registry and individual patient charts. Mortality was calculated and a Cox proportional hazards regression model was used to identify independent predictors for early and late mortality. Mean follow-up was 2.4 years.
  
  
  RESULTS
  Seventy-seven of the 189 patients died within 30 days (41%). Urgent repair (Risk Ratio 4.2 (2.0-8.9), P<0.001) and posterior rupture (RR 2.1 (1.3-3.4), P=0.002) were independent predictors of 30-day mortality. Total cumulative survival (Kaplan-Meyer) was 38% at 5 years. For patients that survived the first 30 days (n=112), 5 year cumulative survival was 67%. Independent predictors for mortality after 30 days were number of concomitant coronary anastomoses (RR 1.5 (1.2-2.0), P=0.001), residual postoperative shunt (RR 2.7 (1.4-5.4), P=0.004) and postoperative dialysis (RR 3.4 (1.5-7.5), P=0.003).
  
  
  CONCLUSIONS
  Early mortality after surgical repair of post infarction septal rupture is still considerable. Early repair and posterior rupture are predictors of early mortality. Long-term survival in patients surviving the immediate postoperative period is limited by pre-existing coronary artery disease, postoperative renal failure and the presence of a residual postoperative shunt.
authors.affiliation: Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden. anders.jeppsson@vgregion.se
authors.forename: Anders
authors.initials: A
authors.lastname: Jeppsson
authors.forename: Hans
authors.initials: H
authors.lastname: Liden
authors.forename: Per
authors.initials: P
authors.lastname: Johnsson
authors.forename: Marianne
authors.initials: M
authors.lastname: Hartford
authors.forename: Kjell
authors.initials: K
authors.lastname: Rådegran
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000379:methods; D017023:Coronary Angiography / Q000379:methods; D001026:Coronary Artery Bypass; D005260:Female; D006342:Heart Rupture, Post-Infarction / Q000601:surgery; D006345:Heart Septal Defects, Ventricular / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality; D011183:Postoperative Complications / Q000209:etiology; D011300:Preoperative Care / Q000379:methods; D018570:Risk Assessment / Q000379:methods; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome