No evidence of pancreatic autoimmunity among patients with multiple sclerosis.
Although multiple sclerosis (MS) usually appears isolated from other autoimmune disorders, an overlap with type 1 diabetes mellitus (T1DM) has been described in Sardinia, where T1DM-associated haplotype HLA-B18-DR3-DQ2 contributes to MS risk. To determine whether in our population MS patients show signs of pancreatic autoimmunity and share this haplotype, sera from 49 MS patients were tested for GAD, IA2, and CPH autoantibodies, and MICA exon 5 polymorphism was genotyped in 30 patients. Pancreatic autoimmune markers were not present among MS patients, nor was any MICA allele associated with MS. Overall, there is no evidence supporting a T1DM/MS overlap in our population.
Bilbao
J Ramón
JR
Endocrinology and Diabetes Research Group, Hospital de Cruces, Plaza de Cruces s/n, Barakaldo E48903 Bizkaia, Spain.
Villoslada
Pablo
P
Martin-Pagola
Ainhoa
A
Castaño
Luis
L
D000328:Adult; D000483:Alleles; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000235:genetics / Q000276:immunology*; D043423:Carboxypeptidase H / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D005968:Glutamate Decarboxylase / Q000276:immunology; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics / Q000276:immunology*; D010179:Pancreas / Q000276:immunology*; D013030:Spain
D001323:Autoantibodies; D015395:Histocompatibility Antigens Class I; C096322:ICA512 autoantibody; C099187:MHC class I-related chain A; D043423:Carboxypeptidase H; D005968:Glutamate Decarboxylase