[Expression of PDGF-B after fluid percussion brain injury in rats].
OBJECTIVE
To elucidate the changes of PDGF-B chain in the brain injured by fluid percussion.


METHODS
The expression of PDGF-B protein was studied by immunohistochemistry and the results were assessed by image analysis system.


RESULTS
Enhanced expression of PDGF-B protein induced by fluid percussion injury was seen at 1 h, and its marked up-regulation was noted at 4-7 days, and then the expression became decreased but it remained above the control levels till 14 days after injury.


CONCLUSIONS
Fluid percussion brain injury induced expression of PDGF-B. The regular change pattern of PDGF-B level in time course seems to be of value in estimating the age of brain injury.
Li
Lei-bo
LB
Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Chen
Xiao-gang
XG
Liu
Min
M
Zhang
Lin
L
Wang
Shi-chun
SC
Liao
Zhi-gang
ZG
He
Gui-qiong
GQ
D000818:Animals; D001930:Brain Injuries / Q000378:metabolism*; D049429:Forensic Pathology; D008297:Male; D020574:Proto-Oncogene Proteins c-sis / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D015854:Up-Regulation
D020574:Proto-Oncogene Proteins c-sis