Reading signals on the nucleosome with a new nomenclature for modified histones.
The tails of the four core histones are exposed on the nucleosome surface, where they are subject to a variety of enzyme-catalyzed, post-translational modifications. Modifications, singly or in combination, provide a source of information that can be used for signal transduction during ongoing processes, such as transcription, or as heritable epigenetic marks. A nomenclature is presented that allows patterns of histone modification to be clearly and unambiguously specified and that should facilitate discussion of their functional roles.
Turner
Bryan M
BM
Chromatin and Gene Expression Group, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham B15 2TT, UK. b.m.turner@bham.ac.uk
D000818:Animals; D001120:Arginine / Q000737:chemistry / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000145:classification* / Q000378:metabolism*; D008239:Lysine / Q000737:chemistry / Q000378:metabolism; D009707:Nucleosomes / Q000737:chemistry / Q000378:metabolism*; D009626:Terminology as Topic
D006657:Histones; D009707:Nucleosomes; D001120:Arginine; D008239:Lysine