title: Lysosomal stability in Oreochromis mossambicus (Peters) on exposure to surfactants.
abstract: The three commonly used surfactants viz. anionic sodium dodecyl sulfate (SDS), cationic cetyl tri methyl ammonium bromide (CTAB) and non-ionic triton X-100 were toxic even at sub lethal levels (1 ppm for 30 days) to 0. mossambicus. Lysosomal stability index (LSI) was lowest in triton-exposed animals in vitro. In vivo, CTAB was the most toxic. SDS, the anionic surfactant was the least toxic. The possible role of surfactant structure, critical micellar concentration (CMC) and metabolism in influencing the toxicity is discussed and mechanism of action via membrane lipid peroxidation is suggested.
authors.affiliation: Department of Marine Biology, Cochin University of Science and Technology, Kochi 682 016, India.
authors.forename: P C
authors.initials: PC
authors.lastname: Bindu
authors.forename: Babu
authors.initials: B
authors.lastname: Philip
authors.forename: R Vinu
authors.initials: RV
authors.lastname: Chandran
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000633:toxicity; D007425:Intracellular Membranes / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D017830:Octoxynol / Q000633:toxicity; D012967:Sodium Dodecyl Sulfate / Q000633:toxicity; D013501:Surface-Active Agents / Q000633:toxicity*; D017210:Tilapia / Q000378:metabolism*; D018675:Toxicity Tests
chemical_list: D015415:Biomarkers; D002593:Cetrimonium Compounds; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D017830:Octoxynol; D000135:Acid Phosphatase; D000077286:Cetrimonium