title: Inclusion complexes of N-sulfamoyloxazolidinones with beta-cyclodextrin.
abstract: A study of inclusion complexes of six N-sulfamoyloxazolidinone derivatives with beta-cyclodextrin is described. The inclusion complexes were prepared in solution and in solid state with stoichiometry host-guest 1:1, and characterized. In solution, the complexation was carried out by spectrophotometric measurements at 25 degrees C. The stoichiometries and stability constants of complexes at various pHs have been determined using second-derivative spectrophotometry UV-vis. Hydrophobic properties of N-sulfamoyloxazolidinones are improved following their inclusion into beta-CD.
authors.affiliation: Laboratoire de Chimie Appliquée, Université de Guelma, BP401, Guelma 24000, Algeria. mekadri@yahoo.fr
authors.forename: Mekki
authors.initials: M
authors.lastname: Kadri
authors.forename: Rayenne
authors.initials: R
authors.lastname: Djemil
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdaoui
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Winum
authors.forename: Frédéric
authors.initials: F
authors.lastname: Coutrot
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montero
mesh_terms: D016503:Drug Delivery Systems; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D046911:Macromolecular Substances / Q000737:chemistry*; D023303:Oxazolidinones / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D013053:Spectrophotometry; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D046911:Macromolecular Substances; D023303:Oxazolidinones; D012996:Solutions; D047392:beta-Cyclodextrins; C031215:betadex