Application of the Continuous Glucose Monitoring System (CGMS) in the 72-hour fast test in two patients with hypoglycemia.
OBJECTIVE
Hypoglycemia occurs in several pathologic states, and the supervised 72-h fast is the classic diagnostic test for hypoglycemia caused by insulinoma. The Continuous Glucose Monitoring System (CGMS), Medtronic MiniMed, Northridge, CA) is an appropriate method to detect asymptomatic hypoglycemia episodes in diabetes mellitus patients. In the present study, we use the CGMS to monitor glucose dynamics during a 72-h fast.


METHODS
Two patients with hypoglycemia disorders were admitted to the hospital for testing. The CGMS sensors were inserted into the subcutaneous tissue prior to starting a 72-h fast test. Finger stick glucose levels were taken every 3-4 h, and the data were entered into the monitor for calibration.


RESULTS
Paired glucose readings from CGMS and conventional meters were correlated significantly (P < 0.001, r2 = 0.79). There was no significant difference between the CGMS glucose levels and conventional meter glucose levels (P > 0.05). Use of CGMS detected a high prevalence of asymptomatic hypoglycemia and two types of hypoglycemia dynamics during a 72-h fast test.


CONCLUSIONS
This initial report using CGMS detected two types of hypoglycemia dynamics during 72-h fasting, which may provide clues to better understand the pathophysiology of hypoglycemia.
Wang
Xiangbing
X
Division of Endocrinology, Department of Medicine, Saint Peter's University Hospital and University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA. xwang@saintpetersuh.com
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005215:Fasting; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000209:etiology*; D018670:Monitoring, Ambulatory / Q000379:methods*; D012984:Software
D001786:Blood Glucose