title: Study on rat subcutaneous reaction to experimental polyurethane elastomers.
abstract: The purpose of the study was to investigate the biocompatibility of experimental elastomers, E580 and E590. The experimental elastomers and the control--a clinically used elastomer--were implanted into the subcutaneous tissue of rats. The tissue reactions were examined histologically on the 3rd, 7th, 14th, 28th, and 56th day after implantation. It was found that there were some irritant responses in the tissues adjacent to the implanted elastomers during the first week. However, the inflammatory tissue reaction subsided substantially from the second week onwards. The stable fibrous capsule surrounding the elastomer was formed after eight weeks. The tissue responses of the control, E580, and E590 were similar. The results suggested that the long-term tissue irritation of the experimental elastomers was so low such that they have the potential to be applied clinically.
authors.affiliation: Graduate School, Department of Dental Engineering, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan. wxingyjp@yahoo.co.jp
authors.forename: Xing Yan
authors.initials: XY
authors.lastname: Wang
authors.forename: Atsuko
authors.initials: A
authors.lastname: Baba
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Maki
authors.initials: M
authors.lastname: Hagio
authors.forename: Koji
authors.initials: K
authors.lastname: Miyazaki
mesh_terms: D000818:Animals; D002208:Caproates / Q000633:toxicity; D020724:Elastomers / Q000633:toxicity*; D020007:Implants, Experimental; D017953:Isocyanates / Q000633:toxicity; D007783:Lactones / Q000633:toxicity; D008297:Male; D011140:Polyurethanes / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D040521:Subcutaneous Tissue / Q000187:drug effects*; D001559:Benzhydryl Compounds
chemical_list: D002208:Caproates; D020724:Elastomers; D017953:Isocyanates; D007783:Lactones; D011140:Polyurethanes; C121056:caprolactone; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds