Oxidative stress and alcoholic liver disease.
Toxic substances generated during the metabolism of alcohol in the liver may contribute to the development of alcoholic liver disease. These substances include highly reactive molecules that can destroy vital cell components through a process called oxidation. Cells are protected against oxidation by the action of certain enzymes, vitamins, and other substances, known collectively as antioxidants. An imbalance between oxidants and antioxidants can lead to oxidative stress, characterized by escalating cell damage. Evidence suggests that the major energy-generating structures within cells (i.e., mitochondria) may be especially sensitive to oxidative stress, resulting in diminished energy production. Medications that reduce oxidative stress in mitochondria may ameliorate liver disease.
Fernández-Checa
J C
JC
Instituto Investigaciones Biomedicas, Consejo Superior Investigaciones Cientificas and Liver Unit, Hospital Clinic i Provincial, Universidad de Barcelona, Barcelona, Spain.
Kaplowitz
N
N
Colell
A
A
García-Ruiz
C
C
D000818:Animals; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology*