[The role of myofibroblast in the development of pathological scar].
OBJECTIVE
To study the effect of myofibroblast on the development of pathological scar.


METHODS
From 1998 to 2000, 14 cases of keloid(k), 13 cases of hypertrophic scar(HS), and 7 cases of scar were studied through immunohistochemistry and electron microscope.


RESULTS
Myofibroblasts were often observed in the hypertrophic HS by electron microscope, but no myofibroblast was observed in the K and NS. alpha-SM-actin was expressed in fibroblast of HS, but was not expressed in K and NS.


CONCLUSIONS
Myofibroblast may play a role in the development of hypertrophic scar. The difference between the absence of myofibroblast in keloid and the invasion of keloid deserves further study.
Liu
Yong
Y
Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu Sichuan 610041, P R China.
Cen
Ying
Y
Ying
Tang
T
Xu
Xuewen
X
D000199:Actins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D017439:Cicatrix, Hypertrophic / Q000378:metabolism / Q000473:pathology*; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007627:Keloid / Q000378:metabolism / Q000473:pathology*; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009130:Muscle, Smooth / Q000737:chemistry; D055815:Young Adult
D000199:Actins