title: Echinosulfonic acid D: an ESI MSn evaluation of a new cytotoxic alkaloid from the New-Caledonian sponge Psammoclemma sp.
abstract: A new bromoindolesulfonic acid derivative, echinosulfonic acid D (1) was isolated from the New-Caledonian sponge Psammoclemma sp. in a minute quantity. The structure of the alkaloid was established by spectroscopic methods and, in particular, by ESI MSn experiments. Echinosulfonic acid D was cytotoxic to KB cells (IC50 2 microg/mL).
authors.affiliation: Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Shai
authors.initials: S
authors.lastname: Rubnov
authors.forename: Camille
authors.initials: C
authors.lastname: Chevallier
authors.forename: Odile
authors.initials: O
authors.lastname: Thoison
authors.forename: Cécile
authors.initials: C
authors.lastname: Debitus
authors.forename: Olivier
authors.initials: O
authors.lastname: Laprevote
authors.forename: Daniel
authors.initials: D
authors.lastname: Guénard
authors.forename: Thierry
authors.initials: T
authors.lastname: Sévenet
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007624:KB Cells / Q000187:drug effects; D008517:Phytotherapy; D011161:Porifera; D013451:Sulfonic Acids / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; D013451:Sulfonic Acids; C500035:echinosulfonic acid D