title: Durability of FTLA treatment as a medicament for dentin hypersensitivity--abrasion resistance and profiles of fluoride release.
abstract: The purpose of this study was to evaluate the durability of tubules occluded with FTLA treatment by toothbrush abrasion test on the applied surface and by measuring fluoride release from the FTLA components. Dentin specimens with simulated hypersensitive surfaces were treated with APF containing tannic acid. After which, the specimens received lanthanum-chloride-with-powdered-fluoroapatite-glass-ceramics treatment. The specimens were subjected to toothbrush abrasion test up to 6,000 strokes. SEM observation revealed that dentinal tubules of the FTLA treated specimens were completely occluded with fine deposits even after toothbrush abrasion of 6,000 strokes. EPMA analysis revealed that fluoride, lanthanum, and aluminum were the main FTLA components on the dentin surface after 6,000-stroke abrasion. To measure fluoride release from the FTLA components, a slurry was enclosed in a cellulose tube and suspended in deionized water at 37 degrees C. After fluoride was dialyzed against deionized water, a high concentration of fluoride was found to be released from FTLA the components, indicating FTLA treatment's prominent durability. These results suggested that FTLA treatment has a superior resistance against toothbrush abrasion and a high fluoride-releasing performance. These characteristics lend much weight to showing that the FTLA method is an effective and durable medicament for dentin hypersensitivity.
authors.affiliation: Department of Oral Medicine, Division of Operative Dentistry and Endodontics, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan. tomiyama@kdcnet.ac.jp
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tomiyama
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Mukai
authors.forename: Shusaku
authors.initials: S
authors.lastname: Okada
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Negishi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fujihara
authors.forename: Toshio
authors.initials: T
authors.lastname: Kawase
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ueda
authors.forename: Sohei
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Teranaka
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D001031:Apatites; D002417:Cattle; D002516:Ceramics; D003806:Dentin Permeability / Q000187:drug effects; D003807:Dentin Sensitivity / Q000175:diagnosis / Q000188:drug therapy*; D004577:Electron Probe Microanalysis; D005459:Fluorides / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D005460:Fluorides, Topical / Q000494:pharmacology / Q000627:therapeutic use*; D007811:Lanthanum / Q000494:pharmacology / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D014072:Tooth Abrasion; D014099:Toothbrushing
chemical_list: D001031:Apatites; D005460:Fluorides, Topical; C083668:lanthanum trifluoride; D000149:Acidulated Phosphate Fluoride; D007811:Lanthanum; C023506:Glass ceramics; C025105:fluorapatite; D005459:Fluorides