[Neuro-protective effect of naomaitong to brain damage after focal cerebral ischemia reperfusion (I/R) in the aged rats].
OBJECTIVE
To study neuro-protective effect of naomaitong on brain damage after focal cerebral ischemia reperfusion (I/R) in the aged rats.


METHODS
11 groups of 20-22-month old SD rats were subjected to 3 hours of middle cerebral artery occlusion with the intraluminal filament technique, followed by 12 hours of reperfusion. Nervous symptom, oedema of brain, infarct size, morphology and superfine structure of brain, etc were monitored thoughout cerebral ischemia and reperfusion.


RESULTS
Infarct size of brain in ischemia and reperfusion groups were significantly greater. Oedema of it was higher, nervous symptom of it was more serious, and morphology and superfine structure brain were more obvious than those of sham-operated group. Nervous symptom, oedema of brain, infarct size, morphology and superfine structure of brain in treated groups were ligher than those of untreated groups (P < 0.001).


CONCLUSIONS
Naomaitong can protect brain damage after focal cerebral I/R in the aged rats.
Ren
Xiao-qiao
XQ
Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China. Rxq23@sohu.com
Li
Jian-sheng
JS
Feng
Yin-man
YM
Lu
Yue-qing
YQ
D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000150:complications; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000473:pathology* / Q000503:physiopathology; D012250:Rheum / Q000737:chemistry
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents