A review of the clinical and diagnostic utility of laboratory tests for the detection of congenital thrombophilia.
Laboratory tests to detect congenital thrombophilia are frequently requested by clinicians. This review attempts to define (1) whether and to what extent laboratory testing may help clinicians make decisions on patient management, (2) the types of conditions to be investigated, and (3) the types of testing to be performed for each condition.
Tripodi
Armando
A
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milan, Italy. armando.tripodi@unimi.it
D020016:Activated Protein C Resistance / Q000175:diagnosis; D000991:Antithrombins / Q000096:biosynthesis; D002624:Chemistry, Clinical / Q000379:methods*; D005165:Factor V / Q000235:genetics; D015241:Fibrinogens, Abnormal / Q000235:genetics; D005838:Genotype; D006405:Hematology / Q000379:methods*; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D009154:Mutation; D011486:Protein C / Q000096:biosynthesis; D017293:Protein S / Q000096:biosynthesis; D011516:Prothrombin / Q000235:genetics; D015203:Reproducibility of Results; D019851:Thrombophilia / Q000097:blood / Q000151:congenital* / Q000175:diagnosis*
D000991:Antithrombins; D015241:Fibrinogens, Abnormal; D011486:Protein C; D017293:Protein S; D006710:Homocysteine; D005165:Factor V; D011516:Prothrombin