title: Age-related femoral bone loss in men: evidence for hyperparathyroidism and insulin-like growth factor-1 deficiency.
abstract: BACKGROUND
  We sought to determine the extent to which the age-related decline of femoral neck (FN) bone mineral density (BMD) might be explained by the age-related change of body composition and biological parameters and the mechanisms by which these factors might influence FN BMD in men.
  
  
  METHODS
  The relationships between FN BMD and anthropometric, hormonal, and biochemical parameters and bone turnover markers were studied in 82 men aged 25-86 years.
  
  
  RESULTS
  Age was associated with a decline of FN BMD and osteocalcin (OC), bone alkaline phosphatase (bALP), and urinary C-telopeptide (p <.05). The significant relationship between FN BMD and OC (p <.01) did not remain after adjustment for age. With use of multiple linear regression and adjusting for all significant variables associated with FN BMD in univariate analysis (p <.01) (age, weight, lean and fat mass, height, and levels of dehydroepiandrosterone sulfate, insulin-like growth factor [IGF-1], testosterone, and parathyroid hormone [PTH]), age accounted for 29.5% of FN BMD variance. When age was excluded from the model, PTH accounted for 19.5% and IGF-1 for 10% of the FN BMD variance. Bone turnover markers were significantly intercorrelated, and levels of IGF-1 were positively associated with those of bALP and OC (p <.05).
  
  
  CONCLUSIONS
  These results show that age is a strong predictor of FN BMD in men, resulting in a decline of bone remodeling, especially of bone formation. The results also show that, after taking into account anthropometric and other biological factors possibly involved in bone aging, the major part of the effect of age on bone is explained by the age-related increase of PTH and decrease of IGF-1 in men, suggesting that all measures taken to limit these age-related changes may be effective in the prevention of the age-related decline of FN BMD in men.
authors.affiliation: Centre de Gérontologie Clinique Antonin Balmès, CHU Montpellier, France.
authors.forename: Hubert
authors.initials: H
authors.lastname: Blain
authors.forename: Anne
authors.initials: A
authors.lastname: Vuillemin
authors.forename: Arielle
authors.initials: A
authors.lastname: Blain
authors.forename: Francis
authors.initials: F
authors.lastname: Guillemin
authors.forename: Nicole
authors.initials: N
authors.lastname: De Talance
authors.forename: Brigitte
authors.initials: B
authors.lastname: Doucet
authors.forename: Claude
authors.initials: C
authors.lastname: Jeandel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D015519:Bone Density; D002136:Calcium, Dietary / Q000008:administration & dosage; D005272:Femur Neck / Q000378:metabolism*; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications*; D007334:Insulin-Like Growth Factor I / Q000172:deficiency*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology*
chemical_list: D002136:Calcium, Dietary; D007334:Insulin-Like Growth Factor I