title: High serum levels of advanced glycation end products predict increased coronary heart disease mortality in nondiabetic women but not in nondiabetic men: a population-based 18-year follow-up study.
abstract: BACKGROUND
  Advanced glycation end products (AGEs), modification products of glycation or glycoxidation of proteins and lipids, have been linked to premature atherosclerosis in patients with diabetes as well as in nondiabetic subjects.
  
  
  RESULTS
  Serum levels of AGEs were measured with an immunoassay in samples obtained at baseline examination of a random sample of 1141 nondiabetic individuals (535 men and 606 women), aged 45 to 64 years, living in Kuopio, East Finland, or Turku, West Finland in 1982 to 1984. After 18 years of follow-up, all-cause mortality, cardiovascular disease (CVD), and coronary heart disease (CHD) mortality were registered on the basis of copies of death certificates. Multivariate Cox regression model showed a significant association of serum AGEs with all-cause (P=0.012), CVD (P=0.018), and CHD (P=0.008) mortality in women but not in men. Fasting serum AGEs in the highest quartile were an independent risk factor for all-cause (hazards ratio [HR], 1.90; 95% CI, 1.16 to 3.11; P=0.011) and CHD (HR, 6.51; 95% CI, 1.78 to 23.79; P=0.005) mortality in women, even after the adjustment for confounding factors, including highly sensitive C-reactive protein.
  
  
  CONCLUSIONS
  The present study is the first to show that serum levels of AGEs can predict total, CVD, and CHD mortality in nondiabetic women.
authors.affiliation: Diabetes Research Centre, Department of Medicine, Aker University Hospital, Oslo, Finland.
authors.forename: Bente K
authors.initials: BK
authors.lastname: Kilhovd
authors.forename: Auni
authors.initials: A
authors.lastname: Juutilainen
authors.forename: Seppo
authors.initials: S
authors.lastname: Lehto
authors.forename: Tapani
authors.initials: T
authors.lastname: Rönnemaa
authors.forename: Peter A
authors.initials: PA
authors.lastname: Torjesen
authors.forename: Kåre I
authors.initials: KI
authors.lastname: Birkeland
authors.forename: Tore J
authors.initials: TJ
authors.lastname: Berg
authors.forename: Kristian F
authors.initials: KF
authors.lastname: Hanssen
authors.forename: Markku
authors.initials: M
authors.lastname: Laakso
mesh_terms: D015415:Biomarkers; D003327:Coronary Disease / Q000097:blood* / Q000401:mortality*; D003920:Diabetes Mellitus; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D017127:Glycation End Products, Advanced