title: Ulcers and gastritis.
abstract: This article reviews recently published reports on ulcers and gastritis. Helicobacter pylori is known to be an important pathogen involved in gastroduodenal inflammation and peptic ulcers. Conventional endoscopy is of limited usefulness in the evaluation of gastritis, but magnifying endoscopy is evidently helpful in the diagnosis of chronic atrophic gastritis, intestinal metaplasia, and H. pylori infection. A significant reduction in the incidence of refractory ulcers and the prevalence of H. pylori infection in patients with peptic ulcer disease followed the introduction of H. pylori eradication treatment. Chronic H. pylori infection is associated with gastric cancer, and the effect of H. pylori eradication on the prevention of gastric cancer is an important issue that is still a matter of controversy. Endoscopic hemostasis and intravenous proton-pump inhibitor (PPI) infusion represent a widely accepted approach to the treatment of peptic ulcer bleeding. In clinical practice, it is important to prevent recurrent bleeding and to treat patients who do not respond to endoscopic therapy or PPI treatment. Laparoscopic repair for peptic ulcer perforations, with postoperative eradication treatment, has gradually met with acceptance in patients with H. pylori infection. H. pylori infection and its treatment continue to be interesting problems in this field.
authors.affiliation: Dept. of Surgery, Kashiwa Hospital, Jikei University School of Medicine, Kashiwa-shita, Kashiaw City, Chiba, Japan. hkashiwagi.surg@jikei.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Kashiwagi
mesh_terms: D020776:Endoscopes, Gastrointestinal; D005756:Gastritis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D010437:Peptic Ulcer / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D013272:Stomach Diseases / Q000209:etiology; D013274:Stomach Neoplasms / Q000209:etiology*