title: Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress.
abstract: OBJECTIVE
  This study aimed to clarify the effect of statins on spontaneous stroke and to examine the antioxidative effect in artificial transient middle cerebral artery occlusion (tMCAO).
  
  
  METHODS
  Stroke-prone spontaneous hypertensive rats (SHR-SP) were treated with pitavastatin, atorvastatin, simvastatin, or vehicle for 4 weeks. Physiological parameters, serum lipids, and infarct volumes were examined. The markers for oxidative stresses on lipids and DNA were immunohistochemically detected in vehicle-treated or simvastatin-treated SHR-SP with tMCAO.
  
  
  RESULTS
  Atorvastatin and simvastatin decreased infarct volumes, with simvastatin most effective. Simvastatin significantly reduced immunoreactivities for oxidative stress markers for lipids and DNA in neurons after tMCAO.
  
  
  CONCLUSIONS
  The results suggest that the antioxidative properties of statins may be implicated in their beneficial effects against neuronal damage in cerebral ischemia.
authors.affiliation: Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Nagotani
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Sato
authors.forename: Wenri
authors.initials: W
authors.lastname: Zhang
authors.forename: Kentaro
authors.initials: K
authors.lastname: Deguchi
authors.forename: Isao
authors.initials: I
authors.lastname: Nagano
authors.forename: Mikio
authors.initials: M
authors.lastname: Shoji
authors.forename: Koji
authors.initials: K
authors.lastname: Abe
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000447:Aldehydes / Q000276:immunology; D000818:Animals; D000069059:Atorvastatin; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000276:immunology; D004195:Disease Models, Animal; D006538:Heptanoic Acids / Q000627:therapeutic use; D006903:Hydroxymethylglutaryl CoA Reductases / Q000627:therapeutic use*; D020244:Infarction, Middle Cerebral Artery / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008055:Lipids / Q000097:blood; D008239:Lysine / Q000276:immunology; D018384:Oxidative Stress / Q000502:physiology*; D011758:Pyrroles / Q000627:therapeutic use; D011804:Quinolines / Q000627:therapeutic use; D051381:Rats; D011918:Rats, Inbred SHR; D019821:Simvastatin / Q000627:therapeutic use; D016019:Survival Analysis
chemical_list: D000447:Aldehydes; D006538:Heptanoic Acids; D008055:Lipids; C120589:N(epsilon)-hexanoyllysine; D011758:Pyrroles; D011804:Quinolines; D000080242:8-Hydroxy-2'-Deoxyguanosine; D000069059:Atorvastatin; D019821:Simvastatin; D006903:Hydroxymethylglutaryl CoA Reductases; D003849:Deoxyguanosine; C027576:4-hydroxy-2-nonenal; D008239:Lysine; C108475:pitavastatin