title: [Fragile X syndrome and very early onset schizophrenia: a female case study].
abstract: Genotype-phenotype relationship studies for psychiatric disorders in females carrying fragile X syndrome full mutation and premutation underline association with schizo-affective disorders. In female children with X fragile full mutation, only behavioural symptoms and no standardised psychiatric disorders have been systematically explored. Therefore, we report the case of a nine-year-old girl carrying the fragile X syndrome full mutation with a comorbid childhood onset schizophrenia (COS), and of her mother carrying the fragile X syndrome premutation and a comorbid schizotypal personality disorder. The impact of these associations is discussed regarding the recent literature in chromosome anomalies in COS.
authors.affiliation: Service de psychopathologie de l'enfant et de l'adolescent, hôpital Robert-Debré, assistance publique-hôpitaux de Paris, 48 boulevard Sérurier, 75019 Paris, France. valerie.vantalon@rdb.ap-hop-paris.fr
authors.forename: V
authors.initials: V
authors.lastname: Vantalon
authors.forename: V
authors.initials: V
authors.lastname: Briard-Luginbuhl
authors.forename: M C
authors.initials: MC
authors.lastname: Mouren
mesh_terms: D017668:Age of Onset; D002648:Child; D015897:Comorbidity; D005260:Female; D005600:Fragile X Syndrome / Q000150:complications* / Q000523:psychology*; D005838:Genotype; D006801:Humans; D010641:Phenotype; D012559:Schizophrenia / Q000209:etiology* / Q000235:genetics*