title: Severe hypothyroidism caused by hepatic hemangioendothelioma in an infant of a diabetic mother.
abstract: Hemangioendotheliomas can express type 3 iodothyronine deiodinase and cause severe hypothyroidism. The risk of congenital malformations such as vertebral and cardiac abnormalities in infants of diabetic mothers is higher than in babies of healthy women. Here we report an infant of a diabetic mother with hypothyroidism caused by liver hemangioendothelioma. Consumptive hypothyroidism should be an indicator to search for a vascular tumor in infants. Supranormal doses of L-thyroxine might be required for normalization of thyroid function until the tumor involutes or is resected.
authors.affiliation: Division of Endocrinology, Department of Pediatrics, Medical Faculty, Ondokuz Mayis University, TR-55200 Samsun, Turkey. aylaguven@yahoo.com
authors.forename: Ayla
authors.initials: A
authors.lastname: Güven
authors.forename: Canan
authors.initials: C
authors.lastname: Aygun
authors.forename: Hülya
authors.initials: H
authors.lastname: Ince
authors.forename: Murat
authors.initials: M
authors.lastname: Aydin
authors.forename: F Güçlü
authors.initials: FG
authors.lastname: Pinarli
authors.forename: Kemal
authors.initials: K
authors.lastname: Baysal
authors.forename: Sükrü
authors.initials: S
authors.lastname: Küçüködük
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology; D004431:Ear, External / Q000002:abnormalities / Q000473:pathology; D005260:Female; D006390:Hemangioendothelioma / Q000150:complications* / Q000000981:diagnostic imaging / Q000201:enzymology; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology* / Q000503:physiopathology; D007231:Infant, Newborn; D007453:Iodide Peroxidase / Q000378:metabolism; D008113:Liver Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000201:enzymology; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications; D011859:Radiography; D012720:Severity of Illness Index; D013131:Spine / Q000002:abnormalities / Q000000981:diagnostic imaging; D016216:Ultrasonography, Prenatal
chemical_list: C117274:iodothyronine deiodinase type III; D007453:Iodide Peroxidase