DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1.
Nonsyndromic deafness locus (DFNB48) segregating as an autosomal recessive trait has been mapped to the long arm of chromosome 15 in bands q23-q25.1 in five large Pakistani families. The deafness phenotype in one of these five families (PKDF245) is linked to D15S1005 with a lod score of 8.6 at theta=0, and there is a critical linkage interval of approximately 7 cM on the Marshfield human genetic map, bounded by microsatellite markers D15S216 (70.73 cM) and D15S1041 (77.69 cM). MYO9A, NR2E3, BBS4, and TMC3 are among the candidate genes in the DFNB48 region. The identification of another novel nonsyndromic recessive deafness locus demonstrates the high degree of locus heterogeneity for hearing impairment, particularly in the Pakistani population.
Ahmad
Jamil
J
National Centre of Excellence in Molecular Biology, University of the Punjab, 87-West Canal Bank Road, Thokar Niaz Baig, Lahore, 53700 Pakistan.
Khan
Shaheen N
SN
Khan
Shahid Y
SY
Ramzan
Khushnooda
K
Riazuddin
Saima
S
Ahmed
Zubair M
ZM
Wilcox
Edward R
ER
Friedman
Thomas B
TB
Riazuddin
Sheikh
S
D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D003638:Deafness / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree