Geldanamycin analogs.
Benzoquinoid ansamycins can downregulate molecules which are chaperoned by heat shock protein (Hsp90), including numerous tyrosine kinases, steroid receptors, and cell cycle regulatory kinases. 17allylaminol7demethoxygeldanamycin (17AAG) has entered the clinic, but 17dimethyl-aminoethylaminogeldanamycin (17DMA) has emerged as an analog with potential preferential pharmaceutical features.
Sausville
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EA
Developmental Therapeutics Program, National Cancer Institute, Bethesda, MD, USA. esausville@umm.edu
D000970:Antineoplastic Agents / Q000494:pharmacology*; D016227:Benzoquinones; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D018841:HSP90 Heat-Shock Proteins / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D047029:Lactams, Macrocyclic; D046911:Macromolecular Substances; D008297:Male; D018832:Molecular Chaperones / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy; D011809:Quinones / Q000494:pharmacology* / Q000627:therapeutic use; D012680:Sensitivity and Specificity; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D016227:Benzoquinones; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; D046911:Macromolecular Substances; D018832:Molecular Chaperones; D011809:Quinones; C001277:geldanamycin