Statin therapy in the primary and secondary prevention of coronary artery disease in patients with type 2 diabetes. A scientific review.
Type 2 diabetes mellitus has a high and growing prevalence in industrialized countries and constitutes a major cardiovascular risk, often being found in association with other risk factors. Macrovascular complications (coronary, cerebrovascular and peripheral) are the main causes of diabetic morbidity and mortality. Dyslipidemia, a major cardiovascular risk factor, is common in patients with type 2 diabetes. Statins are a safe and efficacious therapy in this context. There are a number of good quality randomized controlled trials evaluating the benefit of statins in type 2 diabetic patients. We will present and discuss the most valid, important and applicable evidence available on primary and secondary prevention of coronary artery disease with statins in patients with type 2 diabetes. We will give practical evidence-based recommendations on selection of patients for prevention with statins.
Paulo
Sérgio
S
Centro de Estudos de Medicina Baseada na Evidência Faculdade de Medicina de Lisboa, Lisboa, Portugal.
Fernandes
Susana
S
Vizinho
Ricardo
R
Carneiro
António Vaz
AV
D003327:Coronary Disease / Q000209:etiology / Q000517:prevention & control*; D048909:Diabetes Complications / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors