1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.
1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described.
Wattanasin
Sompong
S
Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA. sompong.wattanasin@pharma.novartis.com
Kallen
Joerg
J
Myers
Stewart
S
Guo
Qin
Q
Sabio
Michael
M
Ehrhardt
Claus
C
Albert
Rainer
R
Hommel
Ulrich
U
Weckbecker
Gisbert
G
Welzenbach
Karl
K
Weitz-Schmidt
Gabriele
G
D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000187:drug effects* / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D006576:Heterocyclic Compounds, 4 or More Rings; D007659:Ketones; D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1