title: Antihypertensive effect of Iranian Crataegus curvisepala Lind.: a randomized, double-blind study.
abstract: The aim of the present study was to investigate the potential antihypertensive effects of extracts of the flavonoid-rich Iranian flower, Crataegus curvisepala Lind., a member of the Rosaceae family. The hydroalcoholic extract of the leaves and flowers were studied in a double-blind, placebo-controlled clinical trial to determine its effects. A total of 92 men and women with primary mild hypertension, aged 40-60 years, were selected and divided randomly into two groups, receiving either hydroalcoholic extract of C. curvisepala Lind. or placebo three times daily for more than 4 months. Blood pressure (BP) was measured each month. Statistical analysis was carried out using Student's t-test. The results obtained showed a significant decrease in both systolic and diastolic BP after 3 months (p < 0.05). C. curvisepala has a time-dependent antihypertensive effect.
authors.affiliation: Isfahan Cardiovascular Research Center, Sedigheh Tahereh Hospital, Isfahan, Iran. bsr@mui.ac.ir
authors.forename: S
authors.initials: S
authors.lastname: Asgary
authors.forename: G H
authors.initials: GH
authors.lastname: Naderi
authors.forename: M
authors.initials: M
authors.lastname: Sadeghi
authors.forename: R
authors.initials: R
authors.lastname: Kelishadi
authors.forename: M
authors.initials: M
authors.lastname: Amiri
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D027825:Crataegus; D004311:Double-Blind Method; D005260:Female; D035264:Flowers; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007492:Iran; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D018515:Plant Leaves
chemical_list: D000959:Antihypertensive Agents; D010936:Plant Extracts