Tetramethyl thiourea/Co2(CO)8-catalyzed Pauson-Khand reaction under balloon pressure of CO.
A Pauson-Khand type of conversion of enynes to bicyclic cyclopentenones employing the commercially available Co2(CO)8 and tetramethylthiourea (TMTU) as catalysts is described. This method allows a variety of enynes with diverse functional groups to be cyclized into cyclopentenones of interest. [reaction: see text]
Tang
Yefeng
Y
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry, and Laboratory of Chemical Genetics, ShenZhen Graduate School, Peking University, Beijing 100871, China.
Deng
Lujiang
L
Zhang
Yandong
Y
Dong
Guangbin
G
Chen
Jiahua
J
Yang
Zhen
Z
D002248:Carbon Monoxide; D002384:Catalysis; D003500:Cyclization; D011312:Pressure; D013890:Thiourea / Q000031:analogs & derivatives* / Q000737:chemistry
D002248:Carbon Monoxide; D013890:Thiourea; C019107:tetramethylthiourea