title: [Analytical methodology for drug-protein binding studies].
abstract: The qualitative and quantitative aspects of several novel methods for drug-protein binding studies, which include chromatography, capillary electrophoresis, mass spectrometry, nuclear magnetic resonance, cloud-point extraction and microdialysis as well as those of the traditional approaches such as equilibrium dialysis and ultrafiltration are reviewed. The advantages and limitations of these methods are discussed.
authors.affiliation: Pharmaceutical College, Shenyang Pharmaceutical University, Shenyang 110016, China. dawei1204@yahoo.com
authors.forename: Dawei
authors.initials: D
authors.lastname: Zhou
authors.forename: Ledao
authors.initials: L
authors.lastname: Li
authors.forename: Famei
authors.initials: F
authors.lastname: Li
mesh_terms: D002845:Chromatography / Q000379:methods; D019075:Electrophoresis, Capillary / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000302:isolation & purification*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism
chemical_list: D004364:Pharmaceutical Preparations; D011506:Proteins