title: [Preparation of stearic acid solid lipid nanoparticles containing podophyllotoxin].
abstract: OBJECTIVE
  To improve the therapeutic efficacy and reduce the adverse effect of podophyllotoxin (PPT) by wrapping it in stearic acid solid lipid nanoparticles.
  
  
  METHODS
  Stearic acid solid lipid nanoparticles containing podophyllotoxin was prepared using modified microemulsion technique, whose morphology was examined by transmission electron microscope. High-performance of liquid chromatography was employed to determine the entrapment efficiency of PPT in the nanoparticles.
  
  
  RESULTS
  The entrapment efficiency of PPT in the nanoparticles was 85.6% and the mean diameter of the particles was 56.5+/-25.8 nm.
  
  
  CONCLUSIONS
  The stearic acid solid lipid nanoparticles has high entrapment efficiency for PPT and is homogeneous in size, which can be a promising targeted preparation for epidermal delivery.
authors.affiliation: Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Fang-ming
authors.initials: FM
authors.lastname: Xie
authors.forename: Kang
authors.initials: K
authors.lastname: Zeng
authors.forename: Guo-feng
authors.initials: GF
authors.lastname: Li
authors.forename: Zhong-fang
authors.initials: ZF
authors.lastname: Lin
authors.forename: Le-dong
authors.initials: LD
authors.lastname: Sun
mesh_terms: D003218:Condylomata Acuminata / Q000188:drug therapy; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004355:Drug Stability; D008055:Lipids; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D011034:Podophyllotoxin / Q000008:administration & dosage*; D013229:Stearic Acids / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D004337:Drug Carriers; D008055:Lipids; D013229:Stearic Acids; C031183:stearic acid; D011034:Podophyllotoxin