Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801.
The behavioral effects produced by MK-801 (0.4 mg/kg) were compared in mutant DAO-/- mice lacking D-amino acid oxidase activity and normal DAO+/+ mice. Mutant mice display marked diminution of stereotypy and ataxia induced by MK-801 compared to normal mice. Because the D-serine level in the brain of mutant mice is significantly higher than that of normal mice, the elevated D-serine in the brain of mutant mice could antagonize MK-801-induced stereotypy and ataxia.
Hashimoto
Atsushi
A
Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1143, Japan. hashimoto@is.icc.u-tokai.ac.jp
Yoshikawa
Masanobu
M
Niwa
Akira
A
Konno
Ryuichi
R
D000818:Animals; D001259:Ataxia / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics; D003605:D-Amino-Acid Oxidase / Q000172:deficiency* / Q000235:genetics; D016291:Dizocilpine Maleate / Q000633:toxicity*; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*
D016291:Dizocilpine Maleate; C485958:Dao1 protein, mouse; D003605:D-Amino-Acid Oxidase