title: Multimodal integration of EEG, MEG and fMRI data for the solution of the neuroimage puzzle.
abstract: In this paper, advanced methods for the modeling of human cortical activity from combined high-resolution electroencephalography (EEG), magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) data are presented. These methods include a subject's multicompartment head model (scalp, skull, dura mater, cortex) constructed from magnetic resonance images, multidipole source model and regularized linear inverse source estimates of cortical current density. Determination of the priors in the resolution of the linear inverse problem was performed with the use of information from the hemodynamic responses of the cortical areas as revealed by block-designed (strength of activated voxels) fMRI. Examples of the application of these methods to the estimation of the time varying cortical current density activity in selected region of interest (ROI) are presented for movement-related high-resolution EEG data.
authors.affiliation: Department of Human Physiology and Pharmacology, University "La Sapienza", 00185 Rome, Italy. fabio.babiloni@uniroma1.it
authors.forename: Fabio
authors.initials: F
authors.lastname: Babiloni
authors.forename: Donetella
authors.initials: D
authors.lastname: Mattia
authors.forename: Claudio
authors.initials: C
authors.lastname: Babiloni
authors.forename: Laura
authors.initials: L
authors.lastname: Astolfi
authors.forename: Serenella
authors.initials: S
authors.lastname: Salinari
authors.forename: Alessandra
authors.initials: A
authors.lastname: Basilisco
authors.forename: Paolo Maria
authors.initials: PM
authors.lastname: Rossini
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Marciani
authors.forename: Febo
authors.initials: F
authors.lastname: Cincotti
mesh_terms: D000465:Algorithms; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology; D003198:Computer Simulation; D004388:Dura Mater / Q000378:metabolism / Q000502:physiology; D004569:Electroencephalography / Q000379:methods*; D020342:Finite Element Analysis; D005947:Glucose / Q000378:metabolism; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015225:Magnetoencephalography / Q000379:methods*; D008959:Models, Neurological; D009044:Motor Cortex / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology; D013997:Time Factors
chemical_list: D005947:Glucose