Three trifluoromethyl-substituted protoporphyrinogen IX oxidase inhibitors.
The structures of methyl 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate, C15H9ClF3N3O5, (I), methyl 2-chloro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]benzoate, C14H10ClF3N2O4, (II), and 2-[4-chloro-2-fluoro-5-(prop-2-ynyloxy)phenyl]-4-(trifluoromethyl)piperidine-2,6-dione, C15H10ClF4NO3, (III), are similar in their dihedral angles and in the distances between the farthest two atoms. There are two independent molecules in the structure of (I). The dihedral angles between the two aromatic rings in each molecule in (I), between the benzene and tetrahydropyrimidine rings in (II), and between the benzene ring and the five-atom planar portion of the piperidine-2,6-dione ring in (III) are 80.78 (11)/89.75 (11), 89.13 (9) and 87.52 (13) degrees , respectively. The distances between the farthest two atoms, viz. O...F in the two molecules of (I), and Cl...F in (II) and (III), are 11.763 (7)/11.953 (6), 10.734 (10) and 10.889 (9) A, respectively. In all three crystal structures, the molecules are linked to generate sheets of molecules via C-H...O interactions.
Li
Bin
B
State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
Lan
Yu Ming
YM
Hsu
Chi Tung
CT
Liu
Zhen Long
ZL
Song
Hai Bin
HB
Wu
Chao
C
Yang
Hua Zheng
HZ
D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry*; D006540:Herbicides / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009579:Nitrobenzoates / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry*; D050768:Protoporphyrinogen Oxidase / Q000037:antagonists & inhibitors*; D011743:Pyrimidines / Q000737:chemistry*
D004791:Enzyme Inhibitors; D006540:Herbicides; D006845:Hydrocarbons, Fluorinated; D009579:Nitrobenzoates; D010880:Piperidines; D011743:Pyrimidines; D050768:Protoporphyrinogen Oxidase