[Synthesis of new mandelic acid derivatives with preservative action. Synthesis and acute toxicity study].
Starting from the antiseptic action of DL mandelic acid, there were synthesized a series of esters of the mandelic acid, esters which could have preservative action. This study present the synthesis, structure validation and the acute toxicity study, for the new synthesized compounds. The esters were obtained by acylating 4-hydroxybenzoic acid propyl, ethyl, methyl esters and salicylic acid with the DL mandelic chloride (that was protected initially by the hydroxylic group). The structure of the synthesized compounds was confirmed by quantitative elemental analysis and RMN 1H spectral measurements. The acute toxicity was determined for two of the esters, who proved to had a preservative action (previously studied) and indicated that these esters have a small toxicity.
Stan
Cătălina
C
Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Farmacie, Disciplina de Farmacodinamie.
Năstase
V
V
Pavelescu
M
M
Vasile
Cornelia
C
Dumitrache
M
M
Gherase
Florenţa
F
Năstasă
Veronica
V
D004952:Esters; D005520:Food Preservatives / Q000138:chemical synthesis / Q000633:toxicity; D008333:Mandelic Acids / Q000138:chemical synthesis* / Q000633:toxicity; D011310:Preservatives, Pharmaceutical / Q000138:chemical synthesis / Q000633:toxicity
D004952:Esters; D005520:Food Preservatives; D008333:Mandelic Acids; D011310:Preservatives, Pharmaceutical; C037938:mandelic acid