title: New anticoagulants: beyond heparin, low-molecular-weight heparin and warfarin.
abstract: The limitations of traditional anticoagulants, heparin and warfarin, have prompted the development of new anticoagulant drugs for prevention and treatment of both venous and arterial thromboembolism. After a brief review of thrombogenesis and its regulation, this paper focuses on new anticoagulant agents in more advanced stages of clinical testing.
authors.affiliation: Department of Medicine, McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada.
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Bates
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Weitz
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D015507:Drugs, Investigational / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D006801:Humans; D020246:Venous Thrombosis / Q000097:blood / Q000188:drug therapy*; D014859:Warfarin / Q000494:pharmacology*
chemical_list: D000925:Anticoagulants; D015507:Drugs, Investigational; D006495:Heparin, Low-Molecular-Weight; D014859:Warfarin