title: Urine, hair, and nails as indicators for ingestion of uranium in drinking water.
abstract: The concentration of uranium in urine, hair, and nails due to continuous exposure through ingestion of drinking water was studied. The study population consisted of 205 individuals living in 134 different households in southern Finland where drinking water is supplied from private drilled wells. The population was selected to include a broad range of uranium daily intake from drinking water (0.03-2,775 microg d). The uranium content in drinking water, urine (overnight collection), hair and nails was determined by ICPMS. Uranium in urine was corrected for the matrix effects by use of thallium as an internal standard and adjusted by creatinine normalization. Hair and toenail samples were rinsed to remove external contamination prior to acid digestion and analysis. The uranium content in all excretion pathways was correlated with the uranium intake, particularly at elevated levels (> or =10 microg d) where drinking water was the major source of exposure to uranium. The median of the individual uranium absorption factors for urine, hair, and toenails were fu=0.003, fh=0.003, and fn=4 x 10, respectively. The association between the different bioassays was examined. The absorption factor, f1, was calculated for the population with an intake above 10 microg d and was below 0.01 for 72% of the study persons (range 0.0002 to 0.070). No statistically significant difference in f1 values was found between women and men. However, the absorption factor was higher among younger (< 60 y) than older (> or =60 y) subjects and among people with a lower exposure (below 100 microg d) than among those that ingest over 100 microg d.
authors.affiliation: Nuclear Research Center, Negev, P. O. Box 9001, Beer-Sheva, Israel 84190. karpas4@netvision.net.il
authors.forename: Z
authors.initials: Z
authors.lastname: Karpas
authors.forename: O
authors.initials: O
authors.lastname: Paz-Tal
authors.forename: A
authors.initials: A
authors.lastname: Lorber
authors.forename: L
authors.initials: L
authors.lastname: Salonen
authors.forename: H
authors.initials: H
authors.lastname: Komulainen
authors.forename: A
authors.initials: A
authors.lastname: Auvinen
authors.forename: H
authors.initials: H
authors.lastname: Saha
authors.forename: P
authors.initials: P
authors.lastname: Kurttio
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001822:Body Burden; D004435:Eating; D005260:Female; D005387:Finland / Q000453:epidemiology; D006197:Hair / Q000378:metabolism*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009262:Nails / Q000378:metabolism*; D009928:Organ Specificity; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods*; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D014501:Uranium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine*; D014875:Water Pollutants, Radioactive / Q000032:analysis*; D014881:Water Supply / Q000032:analysis*
chemical_list: D014875:Water Pollutants, Radioactive; D014501:Uranium