title: Multicomponent therapeutics for networked systems.
abstract: Therapeutic regimens that comprise more than one active ingredient are commonly used in clinical medicine. Despite this, most drug discovery efforts search for drugs that are composed of a single chemical entity. A focus in the early drug discovery process on identifying and optimizing the activity of combinations of molecules can result in the identification of more effective drug regimens. A systems perspective facilitates an understanding of the mechanism of action of such drug combinations.
authors.affiliation: CombinatoRx, Inc., 650 Albany Street, Boston, Massachusetts 02118, USA.
authors.forename: Curtis T
authors.initials: CT
authors.lastname: Keith
authors.forename: Alexis A
authors.initials: AA
authors.lastname: Borisy
authors.forename: Brent R
authors.initials: BR
authors.lastname: Stockwell
mesh_terms: D002986:Clinical Trials as Topic; D015195:Drug Design; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D009626:Terminology as Topic