AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type.
Phosphorylated AKT has been detected in extranodal NK/T-cell lymphoma, nasal type (ENTL). Either interleukin-2 (IL-2) or interleukin-15 (IL-15) could prevent AKT dephosphorylation and apoptosis in the NK-92 cell line model. IL-15, but not IL-2, was preferentially elevated in patients' serum. AKT and IL-15 may be important in ENTL tumor survival.
Chow
Chit
C
Liu
Angi Y
AY
Chan
Wai S
WS
Lei
Kenny I K
KI
Chan
Wing Y
WY
Lo
Anthony W I
AW
D045744:Cell Line, Tumor; D002470:Cell Survival; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D019409:Interleukin-15 / Q000097:blood / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000166:cytology*; D008223:Lymphoma / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000201:enzymology / Q000276:immunology*; D009669:Nose Neoplasms / Q000201:enzymology / Q000276:immunology*; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism / Q000502:physiology*
D019409:Interleukin-15; D007376:Interleukin-2; D051057:Proto-Oncogene Proteins c-akt