title: [HIV-associated lymphoma -- an unusual cause of pathological mandibular fracture].
abstract: Despite the introduction of highly active antiretroviral therapy (HAART), diffuse large B-cell lymphoma (DLBCL) remains a common malignancy in human immunodeficiency virus (HIV)-infected patients, especially the plasmablastic variant. About 50% of lymphomas in HIV patients are extranodal and half of them occur in the head and neck area. The main oral symptoms are pain, swelling, numbness and tooth mobility. We report the case of a 52-year-old patient with a known HIV infection and fracture of the angular region of the mandible. The fracture did not unite following open reduction and osteosynthesis. A biopsy performed at the time of revision revealed the diagnosis of a primary lymphoma in the mandible. After chemotherapy had induced complete remission of the lymphoma and autogenous iliac crest bone grafting had been performed the fracture united. Primary lymphoma in the mandible is a disease that presents with a nonspecific radiological appearance which may mimic osteomyelitis or periodontal pathology. A rapid and accurate diagnosis is critical for the appropriate treatment. In our experience HIV-positive patients with mandibular fracture should be treated according to the guidelines established for HIV-negative patients. However, risky compromises such as intraoral approach or hazardous fracture fixation should be avoided.
authors.affiliation: Abteilung für Kiefer- und Gesichtschirurgie, Universitätsklinik für Wiederherstellende Chirurgie, Universitätsspital, Basel, Schweiz. cleiggener@uhbs.ch
authors.forename: C S
authors.initials: CS
authors.lastname: Leiggener
authors.forename: Ch
authors.initials: Ch
authors.lastname: Kunz
authors.forename: A
authors.initials: A
authors.lastname: Lohri
authors.forename: K
authors.initials: K
authors.lastname: Fridrich
authors.forename: K
authors.initials: K
authors.lastname: Honigmann
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D016025:Bone Transplantation; D003937:Diagnosis, Differential; D005593:Fracture Fixation, Internal; D005598:Fractures, Spontaneous / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005599:Fractures, Ununited / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008297:Male; D008334:Mandible / Q000473:pathology / Q000601:surgery; D008337:Mandibular Fractures / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008339:Mandibular Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D012086:Reoperation
chemical_list: D014408:Biomarkers, Tumor