title: Hypertension and heart failure: role of neurohormonal mechanisms.
abstract: Hypertension represents the most common associated cause of heart failure, and it is frequently involved in the pathogenesis of left ventricular dysfunction and its progression towards congestive heart failure. A common pathophysiological link of hypertension to heart failure is represented by the abnormalities of the neurohormonal profile and its impact on cardiac function, systemic hemodynamics and salt/water balance. This article synthetically reviews this aspect together with a specific analysis of the significance of measurements of neurohormones for diagnosis and prognostic stratification in heart failure.
authors.affiliation: 2nd Faculty of Medicine, University of Rome La Sapienza, Sant'Andrea Hospital, Rome, Italy. volpema@uniroma1.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Volpe
authors.forename: E
authors.initials: E
authors.lastname: Pagannone
authors.forename: G
authors.initials: G
authors.lastname: Tocci
authors.forename: S
authors.initials: S
authors.lastname: Rubattu
mesh_terms: D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000503:physiopathology* / Q000628:therapy; D018377:Neurotransmitter Agents / Q000502:physiology*
chemical_list: D018377:Neurotransmitter Agents