title: Biomarkers: mining the biofluid proteome.
abstract: Proteomics has brought with it the hope of identifying novel biomarkers for diseases such as cancer. This hope is built on the ability of proteomic technologies, such as mass spectrometry (MS), to identify hundreds of proteins in complex biofluids such as plasma and serum. There are many factors that make this research very challenging beginning with the lack of standardization of sample collection and continuing through the entire analytical process. Fortunately the advances made in the characterization of biofluids using proteomic techniques have been rapid and suggest that these mainly discovery driven approaches will lead to the development of highly specific platforms for diagnosing diseases and monitoring responses to different treatments in the near future.
authors.affiliation: Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA. veenstra@ncifcrf.gov
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Veenstra
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Conrads
authors.forename: Brian L
authors.initials: BL
authors.lastname: Hood
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Avellino
authors.forename: Richard G
authors.initials: RG
authors.lastname: Ellenbogen
authors.forename: Richard S
authors.initials: RS
authors.lastname: Morrison
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid / Q000652:urine; D001798:Blood Proteins / Q000032:analysis*; D006801:Humans; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D020543:Proteome