c-Met signalling: spatio-temporal decisions.
The spatial control of signalling events is critical in determining the outcome of a cellular response. Recent studies on the signal output from the growth factor/receptor HGF/c-Met, demonstrates that the PKC-regulated location of downstream transducers, specifically the MAPkinase ERK1/2, has a profound positive influence on cell migration, despite apparently reducing the steady state level of ERK1/2 activation. The mechanisms involved and the implications for signalling studies are discussed.
Kermorgant
S
S
Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, London, UK.
Parker
P J
PJ
D000818:Animals; D002453:Cell Cycle; D002465:Cell Movement; D002467:Cell Nucleus / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D004789:Enzyme Activation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016023:Integrins / Q000378:metabolism; D020935:MAP Kinase Signaling System; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D015398:Signal Transduction; D013997:Time Factors
D016023:Integrins; D019859:Proto-Oncogene Proteins c-met; D011493:Protein Kinase C; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3