title: Effect of a single dose of rituximab in chronic immune thrombocytopenic purpura in childhood.
abstract: Twenty-two children with immune thrombocytopenic purpura (ITP) with long-lasting thrombocytopenia, adversely affecting their quality of life, were treated with a reduced rituximab regimen in order to eliminate B cells producing anti-platelet antibody. A single dose of rituximab resulted in a response rate similar to that reported for cases in which 4 doses of rituximab were used.
authors.forename: Tillmann
authors.initials: T
authors.lastname: Taube
authors.forename: Hansjörg
authors.initials: H
authors.lastname: Schmid
authors.forename: Harald
authors.initials: H
authors.lastname: Reinhard
authors.forename: Arend
authors.initials: A
authors.lastname: von Stackelberg
authors.forename: Ursula Schulte
authors.initials: US
authors.lastname: Overberg
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D001402:B-Lymphocytes / Q000378:metabolism; D001792:Blood Platelets / Q000737:chemistry / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D000069283:Rituximab; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab