Effect of load and temperature on in vitro degradation of poly(glycolide-co-L-lactide) multifilament braids.
The effects of load and temperature on in vitro degradation behaviors of poly(glycolide-co-L-lactide) 90/10 multifilament braids were investigated in phosphate buffer solution at pH 7.4. The property changes of the braids with time were monitored by tensile test, gel permeation chromatography analysis, and scanning electron microscopy. The interrelationships between material properties, time and experimental conditions were explored. The results showed that the polymer braids gradually lost their strength and molecular weight with the increasing in vitro time. While the load levels applied had no effect on the materials, raising temperatures significantly accelerated the degradation. It was found that for a given tensile breaking strength retention (BSR), the dependence of degradation time on temperature could be illustrated by an Arrhenius-type equation, from which the activation energy could be derived. Further analysis indicated that there are well-defined relationships between molecular weight, BSR and breaking strain retention, and these relationships can be illustrated mathematically. Finally, the surface morphology of the fiber showed visible change during the degradation process.
Deng
M
M
Worldwide R&D, ETHICON, a Johnson & Johnson Company, P.O. Box 151, Somerville, NJ 08876, USA. mdeng@ethus.jnj.com
Zhou
J
J
Chen
G
G
Burkley
D
D
Xu
Y
Y
Jamiolkowski
D
D
Barbolt
T
T
D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry*; D019245:Compressive Strength; D004548:Elasticity; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000032:analysis / Q000737:chemistry*; D008422:Materials Testing; D008970:Molecular Weight; D011100:Polyglycolic Acid / Q000032:analysis / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000032:analysis / Q000737:chemistry*; D013314:Stress, Mechanical; D013499:Surface Properties; D013696:Temperature; D013718:Tensile Strength
D001672:Biocompatible Materials; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid