title: Cortical blindness: clinical and radiologic findings in reversible posterior leukoencephalopathy syndrome: case report and review of the literature.
abstract: OBJECTIVE
  To alert ophthalmologists to the recognition of cortical visual loss as the presenting feature in patients with reversible posterior leukoencephalopathy syndrome (RPLES). Unique radiologic findings are paramount to the diagnosis.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  A patient was seen with perioperative bilateral cerebral visual loss that was misinterpreted initially as an irreversible ischemic event. Further detailed analysis of the radiologic findings and clinical history led to the correct diagnosis.
  
  
  METHODS
  Visual acuity and magnetic resonance imaging (MRI) of the brain.
  
  
  RESULTS
  Recognition of the correct diagnosis of RPLES led to the institution of antihypertensive therapy and recovery of normal vision.
  
  
  CONCLUSIONS
  The diagnosis of RPLES should be considered in all patients with acute cerebral visual loss, especially in the setting of recent surgery, blood transfusion, chemotherapy, immunosuppressant use, hypertension, eclampsia, or seizures. Prompt diagnosis requires close collaboration with a radiologist and an emergent MRI study, which ideally should include diffusion-weighted imaging with calculation of an apparent diffusion coefficient map. Differentiation from acute cerebral ischemia is important in order to avoid permanent visual loss by prompt and vigorous treatment of exacerbating factors such as intermittent hypertension. Prompt diagnosis will also help to avoid potentially dangerous invasive procedures such as thrombolytic therapy.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine, Madison, Wisconsin 53705, USA.
authors.forename: Alon
authors.initials: A
authors.lastname: Kahana
authors.forename: Howard A
authors.initials: HA
authors.lastname: Rowley
authors.forename: Joel M
authors.initials: JM
authors.lastname: Weinstein
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D019575:Blindness, Cortical / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D001794:Blood Pressure; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D020343:Hypertensive Encephalopathy / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D011517:Prothrombin Time; D013577:Syndrome; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity
chemical_list: D000925:Anticoagulants; D000959:Antihypertensive Agents; D005343:Fibrinolytic Agents