Co-existence of pemphigus vulgaris and Hashimoto's thyroiditis.
We report a case of pemphigus vulgaris (PV) associated with Hashimoto's thyroiditis. Direct immunofluorescent studies revealed intercellular deposits of IgG and C3. Both anti-desmoglein (Dsg) 1 and Dsg 3 antibodies were positive in the patient's serum by enzyme-linked immunosorbent assays. HLA genotyping was performed from the patient's peripheral blood leukocytes by polymerase chain reaction. HLA-A*02011, -A*2402101, -DQA1*0104, -DQB1*05031 and -DRB1*1405 alleles, which confer strong susceptibility to Japanese patients with PV, were found. HLA-DQA1*0303 which is strongly associated with Hashimoto's thyroiditis in the Japanese population was also determined.
Iino
Yuko
Y
Department of Dermatology, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku, Tokyo 173-0032, Japan. yuu-yoko@wg8.so-net.ne.jp
Hara
Hiroyuki
H
Suda
Takane
T
Okada
Tomoyoshi
T
Baba
Shunichi
S
Suzuki
Hiroyuki
H
D000368:Aged; D005260:Female; D006801:Humans; D010392:Pemphigus / Q000150:complications*; D013967:Thyroiditis, Autoimmune / Q000150:complications*