Adrenocorticotropic hormone production in breast cancer.
Presence of adrenocorticotropic hormone (ACTH) was investigated in tissues from 150 cases of primary breast cancer. ACTH peptides were detected in 16.7% cases and ACTH expression was higher in post-menopausal cancers. A significant association was noticed between the presence of ACTH and the positive estrogen receptor (ER) status of tumors. The study indicated a probable role of these ectopic ACTH peptides in steroid hormone related pathology of breast cancer.
Poddar
Nitesh Kumar
NK
Protein Research Laboratory (Department of Biosciences), Jamia Millia Islamia, New Delhi 110 025, India.
Saha
Renuka
R
Hedau
Suresh
S
Ray
Amitabha
A
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011960:Receptors, Estrogen / Q000096:biosynthesis
D011960:Receptors, Estrogen; D000324:Adrenocorticotropic Hormone