title: Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study.
abstract: BACKGROUND
  Environmental exposures in early life have been implicated in the aetiology of inflammatory bowel disease.
  
  
  OBJECTIVE
  To examine environmental risk factors prior to the development of inflammatory bowel disease in a paediatric population based case control study.
  
  
  METHODS
  A total of 222 incident cases of Crohn's disease and 60 incident cases of ulcerative colitis occurring before 17 years of age between January 1988 and December 1997 were matched with one control subject by sex, age, and geographical location. We recorded 140 study variables in a questionnaire that covered familial history of inflammatory bowel disease, events during the perinatal period, infant and child diet, vaccinations and childhood diseases, household amenities, and the family's socioeconomic status.
  
  
  RESULTS
  In a multivariate model, familial history of inflammatory bowel disease (odds ratio (OR) 4.3 (95% confidence interval 2.3-8)), breast feeding (OR 2.1 (1.3-3.4)), bacille Calmette-Guerin vaccination (OR 3.6 (1.1-11.9)), and history of eczema (OR 2.1 (1-4.5)) were significant risk factors for Crohn's disease whereas regular drinking of tap water was a protective factor (OR 0.56 (0.3-1)). Familial history of inflammatory bowel disease (OR 12.5 (2.2-71.4)), disease during pregnancy (OR 8.9 (1.5-52)), and bedroom sharing (OR 7.1 (1.9-27.4)) were risk factors for ulcerative colitis whereas appendicectomy was a protective factor (OR 0.06 (0.01-0.36)).
  
  
  CONCLUSIONS
  While family history and appendicectomy are known risk factors, changes in risk based on domestic promiscuity, certain vaccinations, and dietary factors may provide new aetiological clues.
authors.affiliation: Registre des Maladies Inflammatoires Chroniques de l'Intestin (EPIMAD), Service d'Epidémiologie et de Santé Publique, Hôpital Calmette, Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Baron
authors.forename: D
authors.initials: D
authors.lastname: Turck
authors.forename: C
authors.initials: C
authors.lastname: Leplat
authors.forename: V
authors.initials: V
authors.lastname: Merle
authors.forename: C
authors.initials: C
authors.lastname: Gower-Rousseau
authors.forename: R
authors.initials: R
authors.lastname: Marti
authors.forename: T
authors.initials: T
authors.lastname: Yzet
authors.forename: E
authors.initials: E
authors.lastname: Lerebours
authors.forename: J-L
authors.initials: JL
authors.lastname: Dupas
authors.forename: S
authors.initials: S
authors.lastname: Debeugny
authors.forename: J-L
authors.initials: JL
authors.lastname: Salomez
authors.forename: A
authors.initials: A
authors.lastname: Cortot
authors.forename: J-F
authors.initials: JF
authors.lastname: Colombel
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001500:BCG Vaccine / Q000009:adverse effects; D001942:Breast Feeding / Q000009:adverse effects; D016022:Case-Control Studies; D002648:Child; D003093:Colitis, Ulcerative / Q000209:etiology / Q000235:genetics; D003424:Crohn Disease / Q000209:etiology / Q000235:genetics; D004032:Diet; D004485:Eczema / Q000150:complications; D004777:Environment; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000209:etiology* / Q000235:genetics; D008297:Male; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications; D012307:Risk Factors; D014611:Vaccination / Q000009:adverse effects
chemical_list: D001500:BCG Vaccine