title: Successful treatment with splenectomy and interferon alpha against recurred hemophagocytic syndrome in remission state of anaplastic large cell lymphoma following high-dose therapy and autologous peripheral blood stem cell transplantation.
abstract: A 25-yr-old man had been diagnosed as having CD30(+) anaplastic large cell lymphoma associated with hemophagocytic syndrome (HS). He received aggressive frontline chemotherapies and consolidation with autologous peripheral blood stem cell transplantation (PBSCT) following high-dose chemotherapy combined with splenic irradiation (720 cGy in fraction of 180 cGy). However, HS recurred on day 50 of PBSCT without radiologic evidence of lymphoma relapse. On day 56 of PBSCT, splenectomy was performed and pathology showed massive sinusoidal infiltration of histiocytes. On day 68 of PBSCT, administration of interferon alpha was started and maintained for 24 months. HS was completely resolved and he has been alive well and in complete remission (CR), 60 months after initial diagnosis.
authors.affiliation: Department of Hematology, College of Medicine, The Catholic University of Korea, Seoul, Korea. chosg@cmc.cuk.ac.uk
authors.forename: Seok Goo
authors.initials: SG
authors.lastname: Cho
authors.forename: Yong Bok
authors.initials: YB
authors.lastname: Koh
authors.forename: Hong Seok
authors.initials: HS
authors.lastname: Chang
authors.forename: Gyeongsin
authors.initials: G
authors.lastname: Park
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Kang
authors.forename: Jong Won
authors.initials: JW
authors.lastname: Park
authors.forename: Woo Sung
authors.initials: WS
authors.lastname: Min
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D018572:Disease-Free Survival; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D013156:Splenectomy
chemical_list: D016898:Interferon-alpha