7alpha,11beta-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties.
7alpha,11beta-Dimethyl-19-nortestosterone, made by 1,6-methyl addition to 17beta-acetoxy-11beta-methylestra-4,6-dien-3-one, was a highly potent and selective androgen response modulator, with enhanced androgen receptor binding, androgenic activity and anabolic:androgenic ratio over its two monomethyl homologs.
Cook
C Edgar
CE
Organic and Medicinal Chemistry, Science and Engineering Group, Research Triangle Institute, PO Box 12194, Research Triangle Park, NC 27709, USA. cec@rti.org
Kepler
John A
JA
D000728:Androgens / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects; D051381:Rats; D011944:Receptors, Androgen / Q000378:metabolism; D013329:Structure-Activity Relationship; D045165:Testosterone Congeners / Q000138:chemical synthesis* / Q000494:pharmacology
C501167:7alpha,11beta-dimethyl-19-nortestosterone; D000728:Androgens; D004967:Estrogens; D011944:Receptors, Androgen; D045165:Testosterone Congeners; D009277:Nandrolone