title: Successful management of stuttering priapism using home self-injections of the alpha-agonist metaraminol.
abstract: Low-flow priapism can result in impotence if treatment is delayed, yet patients with recurrent priapism often suffer delay before therapy. We describe management of recurrent priapism using self-administered injections of intracavernosal metaraminol (Aramine, Merck), a long-acting vasoconstricting amine that is considered safer than epinephrine. The patient injects as often as once daily using 5-10 mg of drug. Our patient reports rapid detumescence and has not required emergency room visits since starting injections. He denies complications. Treatment of priapism using metaraminol has been suggested in the hospital setting; however, this is the first report of successful home self-administration of the drug.
authors.affiliation: Division of Urology, Wayne State University, Detroit, Michigan 48201, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: McDonald
authors.forename: Richard A
authors.initials: RA
authors.lastname: Santucci
mesh_terms: D000328:Adult; D006801:Humans; D007267:Injections; D008297:Male; D008680:Metaraminol / Q000008:administration & dosage*; D011317:Priapism / Q000188:drug therapy* / Q000209:etiology; D012008:Recurrence; D012646:Self Administration; D012805:Sickle Cell Trait / Q000150:complications; D013566:Sympathomimetics / Q000008:administration & dosage*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
chemical_list: D013566:Sympathomimetics; D014662:Vasoconstrictor Agents; D008680:Metaraminol