title: Axonal oscillations in developing mammalian nerve axons.
abstract: We study neuronal spike propagation in a developing myelinated axon in various stages of its development through detailed computational modeling. Recently, a form of bursting (axonal bursting), has been reported in axons in developing nerves in the absence of potassium channels. We present a computational study using a detailed model for a myelinated nerve in development to explore under what circumstances such an effect can be expected. It is shown that axonal oscillation may be caused by backfiring between the nodes of Ranvier or through backfiring from internodal sodium channels or by reducing the thickness of the myelin wrapping the axon between the nodes of Ranvier.
authors.affiliation: Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, Ohio 45701, USA.
authors.forename: Shangyou
authors.initials: S
authors.lastname: Zeng
authors.forename: Peter
authors.initials: P
authors.lastname: Jung
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology*; D001683:Biological Clocks / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology*; D008959:Models, Neurological; D009431:Neural Conduction / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology*
chemical_list: D015221:Potassium Channels