Peritoneal transplantation of human fetal hepatocytes for the treatment of acute fatty liver of pregnancy: a case report.
We report the case of a 26-year-old second gravida in the third trimester of pregnancy who presented with a history of nausea, repeated vomiting and jaundice. The patient was diagnosed as acute fatty liver of pregnancy. After delivery, the condition of the patient progressed to grade IV encephalopathy and did not improve despite all intensive clinical management measures. After 3 days in grade IV encephalopathy, the patient was infused 3 x 10(8) human foetal hepatocytes. The patient's level of consciousness started improving after 24 hours of foetal hepatocyte transfusion and she recovered completely within 7 days.
Khan
A A
AA
Centre for Liver Research and Diagnostics, Deccan College of Medical sciences and Allied Hospitals, Kanchanbagh, Hyderabad.
Habeeb
A
A
Parveen
N
N
Naseem
B
B
Babu
Ravindra P
RP
Capoor
Adarsh K
AK
Habibullah
Chitoor M
CM
D000208:Acute Disease; D000328:Adult; D005234:Fatty Liver / Q000628:therapy*; D005260:Female; D016332:Fetal Tissue Transplantation; D006501:Hepatic Encephalopathy / Q000628:therapy*; D022781:Hepatocytes / Q000637:transplantation*; D006801:Humans; D007263:Infusions, Parenteral; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*