title: [The role of simultaneous chemotherapy and radiotherapy in the treatment of locally metastasised tumours of the larynx, pharynx and oral cavity].
abstract: In The Netherlands each year there are 2300 new patients with a squamous-cell carcinoma of the larynx, pharynx and oral cavity, and of these, one-third has a locally regionally advanced tumour. An operation can then lead to an unacceptable loss of function, whilst radiotherapy alone has no effect on survival. Compared to radiotherapy alone, the combination of radiotherapy and chemotherapy containing cisplatin, when administered simultaneously, produces a higher percentage of patients with loco-regional control and a higher 3-year survival percentage. This improvement in treatment results is accompanied by an increased acute toxicity.
authors.affiliation: Afd. Hoofd-halsoncologie en -chirurgie, Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis, Plesmanlaan 121, 1066 CX Amsterdam.
authors.forename: A J M
authors.initials: AJ
authors.lastname: Balm
authors.forename: J H
authors.initials: JH
authors.lastname: Schornagel
authors.forename: C R N
authors.initials: CR
authors.lastname: Rasch
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D009362:Neoplasm Metastasis; D010039:Otorhinolaryngologic Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D010610:Pharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D016019:Survival Analysis; D016896:Treatment Outcome