Estrogen receptor-related receptor alpha: a mediator of estrogen response in bone.
Estrogen receptor-related receptor-alpha (ERRalpha) is an orphan nuclear receptor with sequence homology to the estrogen receptors, ERalpha/beta, but it does not bind estrogen. However, several recent studies suggest that ERRalpha not only plays a functional role in osteoblasts but also impinges on the estrogen axis in bone, as it does in at least certain other estrogen target tissues. We summarize here data on ERRalpha and its cellular and molecular modes of action that have broad implications for considering the potential role of this orphan receptor as a new therapeutic target in osteopenic disorders such as osteoporosis as well as other estrogen-responsive conditions.
Bonnelye
E
E
Department of Molecular and Medical Genetics, University of Toronto, Room 6233, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
Aubin
J E
JE
D001141:Aromatase / Q000235:genetics; D001842:Bone and Bones / Q000187:drug effects* / Q000502:physiology; D004967:Estrogens / Q000494:pharmacology*; D005786:Gene Expression Regulation; D006801:Humans; D019001:Nitric Oxide Synthase / Q000235:genetics; D052250:Nitric Oxide Synthase Type III; D010012:Osteogenesis; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D011960:Receptors, Estrogen / Q000502:physiology*; D000097983:ERRalpha Estrogen-Related Receptor
D001141:Aromatase; D004967:Estrogens; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen; D000097983:ERRalpha Estrogen-Related Receptor; C496314:NOS3 protein, human