title: Are proteins made from a limited parts list?
abstract: Understanding the process of protein folding has been recognized as an important challenge for >70 years. It is, quintessentially, a thermodynamic problem and, arguably, thermodynamics is our most powerful discipline for understanding biological systems. Yet, despite all this, we still lack predictive understanding of protein folding. Is something missing from this picture?
authors.affiliation: Jenkins Department of Biophysics, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Fitzkee
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Fleming
authors.forename: Haipeng
authors.initials: H
authors.lastname: Gong
authors.forename: Nicholas
authors.initials: N
authors.lastname: Panasik
authors.forename: Timothy O
authors.initials: TO
authors.lastname: Street
authors.forename: George D
authors.initials: GD
authors.lastname: Rose
mesh_terms: D000465:Algorithms; D006860:Hydrogen Bonding; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D010455:Peptides; D011506:Proteins; D014867:Water; C011083:polyproline