title: Influence of polyglecaprone 25 (Monocryl) supplementation on the biocompatibility of a polypropylene mesh for hernia repair.
abstract: BACKGROUND
  Supplementary polyglecaprone 25 (Monocryl) monofilaments were added to a lightweight pure monofilament polypropylene mesh (PP mesh) to improve intraoperative handling (PP+M mesh). This study was designed to evaluate the influence of this additional supplementation on the biocompatibility in a rodent animal model.
  
  
  METHODS
  Two mesh materials, a composite mesh (PP+M) and the pure polypropylene variant (PP), were compared after subcutaneous implantation in a standardized rat model. Histological analysis of the inflammatory response was performed after 28, 56 and 84 days of implantation. Material absorption, inflammatory tissue reaction, fibrosis and granuloma formation were investigated, as well as the percentage of proliferating and apoptotic cells at the interface.
  
  
  RESULTS
  Both mesh materials showed a slight foreign body reaction involving mainly macrophages and foreign body giant cells. Total absorption of the Monocryl filaments of the PP+M mesh occurred between 56 and 84 days of implantation. Both the inflammatory and the fibrotic reaction were decreased (n.s.) in the PP+M mesh group compared to the pure PP mesh. Whereas the percentage of proliferating cells showed no significant difference, the rate of apoptotic cells was significantly decreased in the PP+M mesh group over the whole implantation period.
  
  
  CONCLUSIONS
  Compared to the pure polypropylene mesh, our data confirm that the use of a polypropylene mesh supplemented with absorbable Monocryl filaments is feasible without additional short-term mesh-related complications in the experimental model or negative side effects on biocompatibility.
authors.affiliation: Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. karsten.junge@post.rwth-aachen.de
authors.forename: K
authors.initials: K
authors.lastname: Junge
authors.forename: R
authors.initials: R
authors.lastname: Rosch
authors.forename: C J
authors.initials: CJ
authors.lastname: Krones
authors.forename: U
authors.initials: U
authors.lastname: Klinge
authors.forename: P R
authors.initials: PR
authors.lastname: Mertens
authors.forename: P
authors.initials: P
authors.lastname: Lynen
authors.forename: V
authors.initials: V
authors.lastname: Schumpelick
authors.forename: B
authors.initials: B
authors.lastname: Klosterhalfen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004146:Dioxanes; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology; D006555:Hernia, Ventral / Q000601:surgery*; D008297:Male; D011091:Polyesters; D011126:Polypropylenes; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000473:pathology; D013526:Surgical Mesh
chemical_list: D001672:Biocompatible Materials; D004146:Dioxanes; D011091:Polyesters; D011126:Polypropylenes; C095495:glycolide E-caprolactone copolymer