title: Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder.
abstract: BACKGROUND
  Hyperactivity of the anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been shown to increase with symptom provocation and to normalize with treatment-induced symptom reduction. Although the functional significance of anterior cingulate involvement in OCD remains unknown, electrophysiological evidence has linked this region to error-processing abnormalities in patients with OCD. In this functional magnetic resonance imaging (fMRI) study, we sought to further localize error-processing differences within the ACC of OCD patients compared with healthy subjects.
  
  
  METHODS
  Event-related fMRI data were collected for eight OCD patients and seven healthy subjects during the performance of a simple cognitive task designed to elicit errors but not OCD symptoms.
  
  
  RESULTS
  Both OCD patients and healthy subjects demonstrated dorsal ACC activation during error commission. The OCD patients exhibited significantly greater error-related activation of the rostral ACC than comparison subjects. Activity in this region was positively correlated with symptom severity in the patients.
  
  
  CONCLUSIONS
  Error-processing abnormalities within the rostral anterior cingulate occur in the absence of symptom expression in patients with OCD.
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, 48109-0118, USA.
authors.forename: Kate Dimond
authors.initials: KD
authors.lastname: Fitzgerald
authors.forename: Robert C
authors.initials: RC
authors.lastname: Welsh
authors.forename: William J
authors.initials: WJ
authors.lastname: Gehring
authors.forename: James L
authors.initials: JL
authors.lastname: Abelson
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Himle
authors.forename: Israel
authors.initials: I
authors.lastname: Liberzon
authors.forename: Stephan F
authors.initials: SF
authors.lastname: Taylor
mesh_terms: D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply / Q000503:physiopathology*; D006801:Humans; D006948:Hyperkinesis / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*
chemical_list: D010100:Oxygen