title: (E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors.
abstract: A series of (E)-phenyl- and -heteroaryl-substituted O-benzoyl- (or acyl)oximes 3a-n were synthesized for evaluating their human lipoprotein-associated phospholiphase A2 (Lp-PLA2) inhibitory activities. The less lipophilic derivatives 3a-c showed the most potent in vitro inhibitory activity on human Lp-PLA2.
authors.affiliation: National Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Republic of Korea.
authors.forename: Tae-Sook
authors.initials: TS
authors.lastname: Jeong
authors.forename: Mi Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hana
authors.initials: H
authors.lastname: Yu
authors.forename: Kyung Soon
authors.initials: KS
authors.lastname: Kim
authors.forename: Joong-Kwon
authors.initials: JK
authors.lastname: Choi
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Woo Song
authors.initials: WS
authors.lastname: Lee
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D010091:Oximes; D010741:Phospholipases A; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase