A novel human G protein-coupled receptor is over-expressed in prostate cancer.
G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the identification of a novel GPCR that shows no significant amino acid identity to any one of the known members of the GPCR superfamily. The gene expression pattern of this receptor is restricted: in normal tissues it is confined to the nervous system and testis, but we also detected gene expression in several tumor types, most notably prostate cancer, suggesting a potential role for this gene as a marker for this disease.
Parmigiani
Raphael B
RB
Ludwig Institute for Cancer Research, Rua Professor Antonio Prudente, 109, 4th floor, São Paulo, SP, Brasil.
Magalhães
Geraldo S
GS
Galante
Pedro A F
PA
Manzini
Carina V B
CV
Camargo
Anamaria A
AA
Malnic
Bettina
B
D000595:Amino Acid Sequence; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D010802:Phylogeny; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D043562:Receptors, G-Protein-Coupled