title: [Prehospital thrombolysis during cardiopulmonary resuscitation].
abstract: Although prehospital cardiac arrest has an incidence of 40-90/100,000 inhabitants per year, there has been a lack of therapeutic options to improve the outcome of these patients. Of all cardiac arrests, 50-70% are caused by acute myocardial infarction (AMI) or massive pulmonary embolism (PE). Thrombolysis has been shown to be a causal and effective therapy in patients with AMI or PE who do not suffer cardiac arrest. In contrast, experience with the use of thrombolysis during cardiac arrest has been limited. Thrombolysis during cardiopulmonary resuscitation (CPR) acts directly on thrombi or emboli causing AMI or PE. In addition, experimental studies suggest that thrombolysis causes an improvement in microcirculatory reperfusion after cardiac arrest. In-hospital and prehospital case series and clinical studies suggest that thrombolysis during CPR may cause a restoration of spontaneous circulation and survival even in patients that have been resuscitated conventionally without success. In addition, there is evidence for an improved neurological outcome in patients receiving a thrombolytic therapy during during CPR. A large randomized, double-blind multicenter trial that has started recently is expected to show if this new therapeutic option can generally improve the prognosis of patients with cardiac arrest.
authors.affiliation: Klinik für Anaesthesiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg. fabian_spoehr@med.uni-heidelberg.de
authors.forename: F
authors.initials: F
authors.lastname: Spöhr
authors.forename: B W
authors.initials: BW
authors.lastname: Böttiger
mesh_terms: D016887:Cardiopulmonary Resuscitation; D004311:Double-Blind Method; D004632:Emergency Medical Services / Q000379:methods*; D006323:Heart Arrest / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000628:therapy; D016032:Randomized Controlled Trials as Topic; D015912:Thrombolytic Therapy / Q000379:methods*