Endemic Burkitt's lymphoma: a polymicrobial disease?
Endemic Burkitt's lymphoma is the most common childhood cancer in equatorial Africa. Two ubiquitous human pathogens are thought to be responsible for the aetiology of this disease: Epstein-Barr virus and Plasmodium falciparum malaria. New data suggest how these two pathogens might interact to result in disease and provide insights into the emerging concepts of polymicrobial disease pathogenesis.
Rochford
Rosemary
R
Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York, USA. rochforr@upstate.edu
Cannon
Martin J
MJ
Moormann
Ann M
AM
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002051:Burkitt Lymphoma / Q000453:epidemiology / Q000209:etiology* / Q000469:parasitology / Q000821:virology; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology; D019353:Endemic Diseases; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000472:pathogenicity*; D006801:Humans; D016778:Malaria, Falciparum / Q000276:immunology / Q000469:parasitology / Q000503:physiopathology*; D010963:Plasmodium falciparum / Q000472:pathogenicity*