title: Genetics of hypertension: lessons learnt from mendelian and polygenic syndromes.
abstract: This brief review discusses genetic and genomic aspects of hypertension. A special emphasis is given to currently available strategies for gene identifications, including studies of rare Mendelian hypertension, candidate gene evaluation, genome-wide scans and approaches based on the comparative genome analysis. We also discuss the growing potential for pharmacogenetic approaches and address briefly the issue of genetic testing in complex polygenic traits.
authors.affiliation: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Western Infirmary, Glasgow, Scotland, UK. ad7e@clinmed.gla.ac.uk
authors.forename: Anna F
authors.initials: AF
authors.lastname: Dominiczak
authors.forename: Nick
authors.initials: N
authors.lastname: Brain
authors.forename: Fadi
authors.initials: F
authors.lastname: Charchar
authors.forename: Martin
authors.initials: M
authors.lastname: McBride
authors.forename: Neil
authors.initials: N
authors.lastname: Hanlon
authors.forename: Wai Kwong
authors.initials: WK
authors.lastname: Lee
mesh_terms: D023281:Genomics; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D020412:Multifactorial Inheritance; D020641:Polymorphism, Single Nucleotide