title: Impaired uterine perfusion associated with metabolic disorders in women with polycystic ovary syndrome.
abstract: BACKGROUND
  Risk factors for cardiovascular disease, including chronic anovulation, obesity, hyperandrogenism, hyperinsulinemia, and dyslipidemia, are commonly observed in women with polycystic ovary syndrome (PCOS). We evaluated uterine perfusion and its correlation with clinical and biochemical parameters in women with PCOS.
  
  
  METHODS
  We performed a pulsed Doppler study on uterine arterial blood flow in 25 women with PCOS and 45 control women with regular menstrual cycles. PCOS was diagnosed based on oligomenorrhea, polycystic ovaries determined by means of ultrasonography, and elevated luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratio.
  
  
  RESULTS
  Women with PCOS had a significantly higher body mass index (BMI) and serum testosterone, and showed insulin resistance and dyslipidemia, including increased total cholesterol, triglyceride, low-density lipoprotein-cholesterol (LDL-C), and decreased high-density lipoprotein-cholesterol (HDL-C). The uterine arterial pulsatility index (PI) in women with PCOS was significantly higher than that in the control women during the follicular phase. The PI was correlated with BMI, LH/FSH ratio, or LDL-C/HDL-C ratio, whereas it was inversely correlated with the HDL-C level. Women with PCOS had reduced endometrial thickness and elevated uterine arterial PI in the luteal phase, in which implantation occurs.
  
  
  CONCLUSIONS
  Elevation of uterine arterial blood flow resistance is associated with risk factors for cardiovascular events. Furthermore, the impaired uterine perfusion in the luteal phase may cause endometrial dysfunction in women with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Okayama University Medical School, 2-5-1 Shikata, Okayama-city, Okayama 700-8558, Japan.
authors.forename: Chebib
authors.initials: C
authors.lastname: Chekir
authors.forename: Mikiya
authors.initials: M
authors.lastname: Nakatsuka
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kamada
authors.forename: Soichi
authors.initials: S
authors.lastname: Noguchi
authors.forename: Aiko
authors.initials: A
authors.lastname: Sasaki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hiramatsu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004717:Endometrium / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005498:Follicular Phase; D005500:Follow-Up Studies; D006801:Humans; D008183:Luteal Phase; D008597:Menstrual Cycle / Q000502:physiology*; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000175:diagnosis; D011336:Probability; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D018570:Risk Assessment; D018608:Ultrasonography, Doppler; D014599:Uterus / Q000098:blood supply* / Q000000981:diagnostic imaging; D014655:Vascular Resistance