title: [Ecogenetic aspects of acute side effects caused by angiotensin converting enzyme inhibitors].
abstract: Angiotensin converting enzyme inhibitors are currently used in the treatment of different cardiovascular diseases. Acute side effects of acei have been attributed to bradykinin. We have evidenced a decrease catabolism of des-arg9-bradykinin in the plasma of patients who presented such side effects. This anomaly is associated with a decreased activity of plasma aminopeptidase p which is, at least partially, of genetic origin.
authors.affiliation: Université de Montreal, Québec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Adam
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D002877:Chromosomes, Human / Q000187:drug effects; D006801:Humans; D007705:Kinins / Q000187:drug effects / Q000378:metabolism
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007705:Kinins