title: Preserved myocardial [123I]metaiodobenzylguanidine uptake in autosomal recessive juvenile parkinsonism: first case report.
abstract: A decrease in myocardial uptake of iodine-123-labeled metaiodobenzylguanidine (123I-MIBG) has been reported in idiopathic Parkinson's disease (PD) using 123I-MIBG myocardial scintigraphy. However, the patient with autosomal recessive juvenile parkinsonism (AR-JP), caused by the parkin gene, presented here showed normal 123I-MIBG myocardial uptake, suggesting that AR-JP is a distinct disease entity from PD. Although the clinical features of AR-JP are sometimes quite similar to those of late-onset idiopathic PD, 123I-MIBG myocardial scintigraphy may be a powerful tool to differentiate PD from other parkinsonian syndromes, including AR-JP.
authors.affiliation: Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan. suzukimd@jikei.ac.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Suzuki
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
authors.forename: Satoshi
authors.initials: S
authors.lastname: Orimo
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Fukumitsu
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abo
authors.forename: Yu
authors.initials: Y
authors.lastname: Kono
authors.forename: Renpei
authors.initials: R
authors.lastname: Sengoku
authors.forename: Akira
authors.initials: A
authors.lastname: Kurita
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Honda
authors.forename: Kiyoharu
authors.initials: K
authors.lastname: Inoue
mesh_terms: D019797:3-Iodobenzylguanidine / Q000493:pharmacokinetics*; D005091:Exons / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging* / Q000235:genetics*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine