title: Dietary supplementation of L-carnosine prevents ischemia/reperfusion-induced renal injury in rats.
abstract: The effects of dietary supplementation of L-carnosine (beta-alanyl-L-histidine) on ischemia/reperfusion-induced acute renal failure (ARF) in rats were examined. Ischemic ARF was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal functional parameters such as blood urea nitrogen, plasma creatinine, creatinine clearance, urine flow, urinary osmolality and fractional excretion of sodium were measured. Renal function in ARF rats markedly decreased at 1 d after reperfusion. Prior feeding of L-carnosine-containing diet (0.0001 w/w%) for 2 weeks attenuated the ischemia/reperfusion-induced renal dysfunction. Histopathological examination of the kidney of ARF rats revealed severe renal damages, such as tubular necrosis, proteinaceous casts in tubuli and medullary congestion, which were also significantly suppressed by the dietary supplementation of L-carnosine. These findings strongly suggest that L-carnosine supplementation is useful as a prophylactic treatment in the development of the ischemic ARF.
authors.affiliation: Department of Pharmacology, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
authors.forename: Toshihide
authors.initials: T
authors.lastname: Fujii
authors.forename: Masanori
authors.initials: M
authors.lastname: Takaoka
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tsuruoka
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kiso
authors.forename: Takaharu
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Matsumura
mesh_terms: D000818:Animals; D002336:Carnosine / Q000008:administration & dosage / Q000627:therapeutic use*; D019587:Dietary Supplements; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000178:diet therapy* / Q000517:prevention & control*
chemical_list: D002336:Carnosine