Mathematical modeling of planar polarity.
Although it is well established that the Frizzled receptor is involved in the transmission of polarity information from cell to cell in the Drosophila cuticle, its precise role is still unclear. A recent paper by presents a mathematical model of a feedback loop-based mechanism for propagation of polarity between cells that can account for the known functions of Frizzled.
Strutt
David
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Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D019521:Body Patterning; D000072261:Dishevelled Proteins; D004330:Drosophila / Q000166:cytology / Q000235:genetics / Q000254:growth & development; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D005246:Feedback; D051157:Frizzled Receptors; D017344:Genes, Insect; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D009154:Mutation; D010750:Phosphoproteins / Q000235:genetics / Q000502:physiology; D043562:Receptors, G-Protein-Coupled; D014921:Wings, Animal / Q000166:cytology / Q000254:growth & development
D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D008565:Membrane Proteins; D010750:Phosphoproteins; D043562:Receptors, G-Protein-Coupled; C058784:fz protein, Drosophila