Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers.
The synthesis of a new zwitterionic diblock copolymer poly(l-glutamic acid)-b-poly(l-lysine) (PGA-b-PLys) is described, and its self-assembly into schizophrenic vesicles that can reversibly be produced in moderate acidic or basic aqueous solutions is reported. These pH-sensitive nanoparticles are expected to be very promising candidates in macromolecular nanobiotechnologies.
Rodríguez-Hernández
Juan
J
Laboratoire de Chimie des Polymères Organiques (LCPO-UMR5629), ENSCPB, University Bordeaux 1, 16, Avenue Pey Berland, 33607 Pessac-Cedex, France.
Lecommandoux
Sébastien
S
D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008027:Light; D008239:Lysine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D008823:Micelles; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D012542:Scattering, Radiation; D012995:Solubility; D014867:Water / Q000737:chemistry
D008823:Micelles; C072409:N-epsilon-trifluoro-lysine; D010455:Peptides; D014867:Water; C003172:poly-gamma-benzyl-L-glutamate; D011099:Polyglutamic Acid; D008239:Lysine