title: [Evaluation of systolic and diastolic function of the left ventricle in children with acute lymphoblastic leukaemia before treatment].
abstract: Between 1995 and 2001 echo-cardiography was performed in 244 children (128 boys, 116 girls) with acute lymphoblastic leukaemia (ALL) before the beginning of therapy with anthracyclines (medium 5.4 days after the diagnosis). The mean age at diagnosis was 5.4 years (range 9 months to 17.7 years). 189 children (97 boys and 92 girls) were included into the standard and medium risk groups and 55 (31 boys and 24 girls) into the high risk group. 29% of ALL children had disturbances in ECG. Changes in the thickness of the intraventricular septum (%IVSTh) and left ventricular posterior wall (%LVPWTh) were statistically lower, especially in children under 7 years of age. Some children showed lowering of shortening fraction (%FS - 8.6%), ejection fraction (%EF - 10.2%) and corrected velocity of fibber-shortening (Vcfc - 25.8%). Children with decreased shortening fraction (%FS) had left ventricular posterior wall thickness (%LVPWTh) impairment. Changes in diastolic function indicate impaired relaxation and compliance of the left ventricle. Decreased peak early filling velocity (E) was found. There were also longer deceleration time (EDecT) and decreased deceleration from peak E velocity (E/Dec) and longer isovolumetric relaxation time in children in standard and medium risk groups. Shorter acceleration time (EAccT) was seen in the high risk group. Evaluation of cardiac function before anthracycline chemotherapy will allow to select patients with pre-existing cardiac impairment for whom cardioprotective treatment is absolutely necessary.
authors.affiliation: Katedra i Klinika Pediatrii, Hematologii i Onkologii, Akademii Medycznej w Warszawie. tjackowska@litewska.edu.pl
authors.forename: Teresa
authors.initials: T
authors.lastname: Jackowska
authors.forename: Marek
authors.initials: M
authors.lastname: Pleskot
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Gołabek
authors.forename: Roma
authors.initials: R
authors.lastname: Rokicka-Milewska
authors.forename: Maria
authors.initials: M
authors.lastname: Wróblewska-Kałuzewska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wypych
authors.forename: Michał
authors.initials: M
authors.lastname: Matysiak
authors.forename: Kinga
authors.initials: K
authors.lastname: Klus
authors.forename: Ewa
authors.initials: E
authors.lastname: Juraszewska
authors.forename: Walentyna
authors.initials: W
authors.lastname: Balwierz
authors.forename: Beata
authors.initials: B
authors.lastname: Wójcik
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Sadurska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kowalczyk
authors.forename: Dariusz
authors.initials: D
authors.lastname: Stencel
authors.forename: Aldona
authors.initials: A
authors.lastname: Siwinska
authors.forename: Jacek
authors.initials: J
authors.lastname: Wachowiak
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szmyd
authors.forename: Ewa
authors.initials: E
authors.lastname: Kukawczyńska
authors.forename: Alicja
authors.initials: A
authors.lastname: Chybicka
authors.forename: Anna
authors.initials: A
authors.lastname: Płoszyńska
authors.forename: Janina
authors.initials: J
authors.lastname: Aleszewicz-Baranowska
authors.forename: Anna
authors.initials: A
authors.lastname: Balcerska
authors.forename: Mariusz
authors.initials: M
authors.lastname: Ostański
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Pobudejska
authors.forename: Danuta
authors.initials: D
authors.lastname: Sońta-Jakimczyk
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Krenke
authors.forename: Wojtek
authors.initials: W
authors.lastname: Madry
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Syczewska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Rudziński
mesh_terms: D000293:Adolescent; D000367:Age Factors; D018943:Anthracyclines / Q000008:administration & dosage; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003971:Diastole; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D011044:Poland; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D012189:Retrospective Studies; D013318:Stroke Volume; D013599:Systole; D013997:Time Factors; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D017725:Ventricular Pressure
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic