[Effect of osteopractic total flavone on bone mineral density and bone histomorphometry in ovariectomized rats].
OBJECTIVE
To observe the effect of osteopractic total flavone on bone histomorphometry of osteoporosis model in rath with ovariectomized female rat models.


METHODS
The ovariectomy-induced model, bone sliceswith calcium, pigmentation, and Leica Qwin image analysis system were adopted on bone histomorphometry.


RESULTS
As compared with the model group, the effect of small-dose group and middle-dose group of osteopractic total flavone on TBV% of shankbone increased significantly; the effect of small-dose group and middle-dose group of osteopractic total flavone on TRS% of shankbone reduced significantly and TFS%, AFS%, MAR, BFR of shankbone reduced obviously; the effect of middle-dose group of osteopractic total flavone on OSW and mAR reduced obviously, the effect of small-dose group of osteopractic total flavone on them had the tendency of reducing, but there was no statistical significance.


CONCLUSIONS
The ovariectomized rats having been fed with osteopractic total flavone for 6 months, TBV% increased significantly while TRS%, AFS%, MAR, BFR, OSW, and mAR reduced obviously. It indicates that the therapeutical effect of osteopractic total flavone on ovariectomy-induced osteoporosis model is significant. And the ovariectomy-induced osteoporosis model is a high transformative type of osteoporosis model in which bone absorption is higher than bone formation.
Xie
Yan-ming
YM
China Academy of Traditional Chinese Medicine, Beijing 100700, China. caigong4408@sohu.com
Ju
Da-hong
DH
Zhao
Jin-ning
JN
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology*; D010024:Osteoporosis / Q000209:etiology / Q000473:pathology*; D010052:Ovariectomy; D029621:Polypodiaceae / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D047309:Flavones