Directed ortho Metalation reaction of aryl O-carbamates on solid support.
The first Directed ortho Metalation (DoM) reaction of aryl O-carbamates on polystyrene-divinylbenzene (PS-DVB) resin using a trityl linker is described. Using low temperatures and short metalation times, a range of electrophiles have been introduced to give, after cleavage from support, substituted benzyl alcohols in high purity. [reaction: see text]
Milburn
Claire
C
Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6.
Milburn
Robert R
RR
Snieckus
Victor
V