Angiogenesis and organ transplantation.
Angiogenesis is a vessel development process that maintains the vascular supply for organ function. Regulation of angiogenesis is provided by positive factors, such as vascular endothelial or basic fibroblast growth factors, and negative factors, such as thrombospondin and macrophage-derived inflammatory cytokines. While the role of angiogenesis in the wound healing, embryogenesis, tumor growth and proliferative diseases is clear, in organ transplantation it is not yet well established. Herein we discuss the potential role of angiogenesis in chronic renal disease and in transplant settings.
Rajnoch
J
J
Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czechia.
Viklický
O
O
D042682:Angiopoietins / Q000502:physiology; D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000502:physiology; D006084:Graft Rejection; D017228:Hepatocyte Growth Factor / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000293:injuries; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D016377:Organ Transplantation; D012259:Ribonuclease, Pancreatic / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D053773:Transforming Growth Factor beta1; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D042682:Angiopoietins; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D017228:Hepatocyte Growth Factor; C046366:angiogenin; D012259:Ribonuclease, Pancreatic