title: Syntheses and antibacterial activity of a series of 3-(pyridine-3-yl)-2-oxazolidinone.
abstract: The syntheses of substituted piperazinyl pyridyl oxazolidinones 8-16 are described. Their in vitro activities against Gram-positive organisms such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus and enterococcus were evaluated by minimum inhibitory concentration (MIC) determination. Compound 8 and 10 were found to be superior to linezolid.
authors.affiliation: Laboratoire de Pharmacochimie Moléculaire et Systèmes Membranaires, Université Paris 7-Denis Diderot, 75251 Paris cedex 05, France. yingjie.cui@paris7.jussieu.fr
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Cui
authors.forename: Yaxian
authors.initials: Y
authors.lastname: Dang
authors.forename: Yushe
authors.initials: Y
authors.lastname: Yang
authors.forename: Shuhua
authors.initials: S
authors.lastname: Zhang
authors.forename: Ruyun
authors.initials: R
authors.lastname: Ji
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016983:Enterococcus / Q000187:drug effects; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D011725:Pyridines; D000069349:Linezolid; C023666:pyridine