title: crossveinless defines a new family of Twisted-gastrulation-like modulators of bone morphogenetic protein signalling.
abstract: The Twisted gastrulation (Tsg) proteins are modulators of bone morphogenetic protein (BMP) activity in both vertebrates and insects. We find that the crossveinless (cv) gene of Drosophila encodes a new tsg-like gene. Genetic experiments show that cv, similarly to tsg, interacts with short gastrulation (sog) to modulate BMP signalling. Despite this common property, Cv shows a different BMP ligand specificity as compared with Tsg, and its expression is limited to the developing wing. These findings and the presence of two types of Tsg-like protein in several insects suggest that Cv represents a subgroup of the Tsg-like BMP-modulating proteins.
authors.affiliation: Department of Developmental and Cell Biology, Developmental Biology Center, University of California at Irvine, Irvine, California 92697, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Vilmos
authors.forename: Rui
authors.initials: R
authors.lastname: Sousa-Neves
authors.forename: Tamas
authors.initials: T
authors.lastname: Lukacsovich
authors.forename: J Lawrence
authors.initials: JL
authors.lastname: Marsh
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism*; D004058:Diffusion; D029721:Drosophila Proteins / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D023281:Genomics; D008024:Ligands; D008297:Male; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017384:Sequence Deletion / Q000235:genetics; D015398:Signal Transduction; D013379:Substrate Specificity; D014921:Wings, Animal / Q000254:growth & development / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D029721:Drosophila Proteins; D008024:Ligands; C090223:TSG protein, Drosophila; C091428:sog protein, Drosophila