Microbial production and applications of chiral hydroxyalkanoates.
Polyhydroxyalkanoates (PHA) are a family of polyesters consisting of over 150 chiral hydroxyalkanoic acids (HA). This paper reviews the physiological functions of (R)-3-hydroxybutyric acid (3HB) and (R)-4-hydroxybutyric acid and summarizes the technologies developed to produce various HA [3HB, (R)-3-hydroxyoctanoic acid, (R)-3-hydroxydecanoic acid, etc.] and the applications of chiral HA. Their outlooks and perspectives are discussed.
Chen
Guo-Qiang
GQ
MOE Laboratory of Protein Science, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China. chengq@mail.tsinghua.edu.cn
Wu
Qiong
Q
D020155:3-Hydroxybutyric Acid / Q000378:metabolism; D000217:Acyltransferases / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism*; D002210:Caprylates / Q000378:metabolism; D003652:Decanoic Acids / Q000378:metabolism; D006880:Hydroxy Acids / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000378:metabolism; D007218:Industrial Microbiology; D013237:Stereoisomerism
D002210:Caprylates; D003652:Decanoic Acids; D006880:Hydroxy Acids; D006885:Hydroxybutyrates; C111420:4-hydroxybutyric acid; C101940:3-hydroxyoctanoic acid; D000217:Acyltransferases; C077225:poly(3-hydroxyalkanoic acid) synthase; C017552:myrmicacin; D020155:3-Hydroxybutyric Acid