title: [Genetic polymorphism of 5 short tandem repeat loci in Hui population in Ningxia area].
abstract: OBJECTIVE
  To analyze the genetic polymorphism of 5 short tandem repeat(STR) loci in Hui population in Ningxia area.
  
  
  METHODS
  The genetic polymorphisms of five selected STR loci(D11S1984, D14S306, D14S617, D17S1290 and D19S433) in chromosomes 11, 14, 17 and 19 in 144 unrelated individuals in Hui population in Ningxia area were analyzed by PCR amplification, denaturing polyacrylamide gel electrophoresis(PAGE) and silver staining.
  
  
  RESULTS
  10, 8, 11, 13 and 8 alleles, 30, 25, 33, 40 and 23 genotypes of the 5 STR loci in Hui population in Ningxia were detected. The measured values of the heterozygosity of the 5 STR loci were 0.8413, 0.8033, 0.8331, 0.8369 and 0.7703; of the polymorphism information content were 0.8217, 0.7746, 0.8121, 0.8174 and 0.7332; of the discrimination power (DP) were 0.9516, 0.9257, 0.9611, 0.9660 and 0.9135. The calculated discrimination power was 0.9999995. The measured values of paternity exclusion were 0.7046, 0.6367, 0.6911, 0.7012 and 0.5801; the calculated paternity exclusion was 0.9958. The genotype distributions were in accordance with Hardy-Weinberg equilibrium.
  
  
  CONCLUSIONS
  The 5 STR loci have better polymorphism in Hui population in the Ningxia area, and thus could serve as useful markers for population genetics research and for individual identification and paternity test in forensic medicine.
authors.affiliation: School of Life Science, Ningxia University, Yinchuan, Ningxia, 750021 PR China. wyj@nxu.edu.cn
authors.forename: Yu-jiong
authors.initials: YJ
authors.lastname: Wang
authors.forename: Chen-hong
authors.initials: CH
authors.lastname: Guo
authors.forename: Chang
authors.initials: C
authors.lastname: Shu
authors.forename: Li-tong
authors.initials: LT
authors.lastname: Ma
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yue
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic