title: Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
abstract: The internalization of various cargo proteins and lipids from the mammalian cell surface occurs through the clathrin and lipid-raft endocytic pathways. Protein-lipid and protein-protein interactions control the targeting of signalling molecules and their partners to various specialized membrane compartments in these pathways. This functions to control the activity of signalling cascades and the termination of signalling events, and therefore has a key role in defining how a cell responds to its environment.
authors.affiliation: Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Room 1075, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
authors.forename: Christine
authors.initials: C
authors.lastname: Le Roy
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Wrana
mesh_terms: D002966:Clathrin / Q000737:chemistry / Q000502:physiology*; D004705:Endocytosis; D066246:ErbB Receptors / Q000378:metabolism; D006028:Glycosphingolipids / Q000737:chemistry; D008055:Lipids / Q000737:chemistry; D021962:Membrane Microdomains; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D008956:Models, Chemical; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D002966:Clathrin; D006028:Glycosphingolipids; D008055:Lipids; D018125:Receptors, Transforming Growth Factor beta; D066246:ErbB Receptors