apoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice.
Increased anxiety may occur in up to 70% of AD patients during the course of their illness. Here we show that human apoE isoforms, which differ in AD risk, have differential effects on measures of anxiety in adult Apoe-/- male mice expressing human apoE3 or apoE4 in their brains and male probable AD (PRAD) patients. Compared with wild-type mice, Apoe-/- mice without human apoE or with apoE4, but not apoE3, showed increased measures of anxiety. These behavioral alterations were associated with reduced microtubule-associated protein 2-positive neuronal dendrites in the central nucleus of the amygdala. Consistent with the mouse data, male and female PRAD patients with epsilon4/epsilon4 showed higher anxiety scores than those with epsilon3/epsilon3. We conclude that human apoE isoforms have differential effects on measures of anxiety.
Robertson
Jennifer
J
Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Curley
Justine
J
Kaye
Jeffrey
J
Quinn
Joseph
J
Pfankuch
Timothy
T
Raber
Jacob
J
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000209:etiology / Q000378:metabolism*; D001057:Apolipoproteins E / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D001522:Behavior, Animal; D005260:Female; D005938:Glucocorticoids / Q000134:cerebrospinal fluid; D006801:Humans; D006854:Hydrocortisone / Q000134:cerebrospinal fluid; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008875:Middle Aged; D020033:Protein Isoforms / Q000378:metabolism*; D012022:Reflex, Acoustic / Q000235:genetics; D012737:Sex Factors; D020182:Sleep Apnea, Central / Q000150:complications
D001057:Apolipoproteins E; D005938:Glucocorticoids; D020033:Protein Isoforms; D006854:Hydrocortisone