title: Granulomatous interstitial nephritis associated with bone marrow transplantation.
abstract: We describe two brothers with severe combined immunodeficiency, who presented with systemic granulomatous disease, with granulomatous interstitial nephritis as the main feature, several years following bone marrow transplantation. Neither brother had an apparent drug-induced, infectious disease or autoimmune source for the granulomatous interstitial nephritis. Both patients' renal function improved following treatment with corticosteroids. This report implicates granulomatous interstitial nephritis as a complication of bone marrow transplantation for severe combined immunodeficiency.
authors.affiliation: Division of Pediatric Nephrology, Golisano Children's Hospital at Strong, Department of Pediatrics, University of Rochester, Rochester, New York, USA. andrew_schwaderer@urmc.rochester.edu
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Schwaderer
authors.forename: Lois
authors.initials: L
authors.lastname: Arend
authors.forename: Marc B
authors.initials: MB
authors.lastname: Lande
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D041321:Chromosomes, Human, X; D008040:Genetic Linkage; D006099:Granuloma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D009395:Nephritis, Interstitial / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D016511:Severe Combined Immunodeficiency / Q000235:genetics / Q000601:surgery*; D014463:Ultrasonography
chemical_list: D000305:Adrenal Cortex Hormones