[Implantation of preserved human amniotic membrane for the treatment of shield ulcers and persistent corneal epithelial defects in chronic allergic keratoconjunctivitis].
OBJECTIVE
To determine whether amniotic membrane implantation is a safe and effective alternative treatment for shield ulcers and persistent corneal epithelial defects associated with ulcers in chronic allergic keratoconjunctivitis (vernal or atopic keratoconjunctivitis).


METHODS
Amniotic membrane implantation was performed in four consecutive patients with persistent corneal epithelial defects or vernal plaques unresponsive to conventional medical treatment lasting an average of 18 weeks. Surgery was done under general anesthesia using amniotic membrane as a therapeutic contact lens.


RESULTS
A significant decrease in symptoms and complete reepithelialization of the corneal ulcers were observed in all cases within the first 7 days. These remained stable during a mean follow-up of 12 weeks, with no intraoperative or postoperative complications. Early detachment occurred in all cases with no negative consequences on ulcer healing.


CONCLUSIONS
Patients with severe chronic allergic keratoconjunctivitis derive benefits from amniotic membrane implantation used as a therapeutic contact lens in the treatment of persistent corneal epithelial defects and vernal plaques unresponsive to conventional medical treatment.
Rouher
N
N
Service d'Ophtalmologie, Hôpital Gabriel Montpied, CHRU Clermont-Ferrand, Place Henri Dunant, 63000 Clermont-Ferrand Cedex, France. nicolas.rouher@infonie.fr
Pilon
F
F
Dalens
H
H
Fauquert
J-L
JL
Kemeny
J-L
JL
Rigal
D
D
Chiambaretta
F
F
D000293:Adolescent; D000328:Adult; D001684:Biological Dressings; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003233:Conjunctivitis, Allergic / Q000150:complications; D003320:Corneal Ulcer / Q000209:etiology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male