Identification of genes involved in the glyoxylate regeneration cycle in Methylobacterium extorquens AM1, including two new genes, meaC and meaD.
The glyoxylate regeneration cycle (GRC) operates in serine cycle methylotrophs to effect the net conversion of acetyl coenzyme A to glyoxylate. Mutants have been generated in several genes involved in the GRC, and phenotypic analysis has been carried out to clarify their role in this cycle.
Korotkova
Natalia
N
Department of Chemical Engineering, University of Washington, Seattle, WA 98195, USA.
Lidstrom
Mary E
ME
Chistoserdova
Ludmila
L
D000105:Acetyl Coenzyme A / Q000378:metabolism; D005798:Genes, Bacterial; D006038:Glyoxylates / Q000378:metabolism*; D020601:Methylobacterium extorquens / Q000201:enzymology* / Q000235:genetics*
D006038:Glyoxylates; D000105:Acetyl Coenzyme A; C031150:glyoxylic acid