title: Actin-based motility of intracellular pathogens.
abstract: The actin cytoskeleton is harnessed by several pathogenic bacteria that are capable of entering into non-phagocytic cells, the so-called 'invasive bacteria'. Among them, a few also exploit the host actin cytoskeleton to move intra- and inter-cellularly. Our knowledge of the basic mechanisms underlying actin-based motility has dramatically increased and the list of bacteria that are able to move in this way is also increasing including not only Listeria, Shigella and Rickettsia species but also Mycobacterium marinum and Burkholderia pseudomallei. In all cases the central player is the Arp2/3 complex. Vaccinia virus moves intracellularly on microtubules and just after budding, triggers actin polymerization and the formation of protrusions similar to that of adherent enteropathogenic Escherichia coli, that involve the Arp2/3 complex and facilitate its inter-cellular spread.
authors.affiliation: Unité des Interactions Bactéries-cellules, Institut Pasteur, 28 Rue du Docteur Roux, Paris 75015, France.
authors.forename: Edith
authors.initials: E
authors.lastname: Gouin
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Welch
authors.forename: Pascale
authors.initials: P
authors.lastname: Cossart
mesh_terms: D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins / Q000378:metabolism*; D001419:Bacteria / Q000472:pathogenicity*; D018407:Bacterial Physiological Phenomena; D002465:Cell Movement / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000378:metabolism; D005057:Eukaryotic Cells / Q000382:microbiology / Q000821:virology; D006801:Humans; D014616:Vaccinia virus / Q000472:pathogenicity* / Q000502:physiology*
chemical_list: C495926:ACTR2 protein, human; C495928:ACTR3 protein, human; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins; D003598:Cytoskeletal Proteins