Thromboembolic diseases in neonates and children.
Acquired and inherited prothrombotic risk factors increase the risk of thrombosis in neonates, infants and children. After suffering thrombosis white paediatric patients should be screened for common gene mutations, i.e. the factor V G1691A, factor II G20210A and MTHFR C677T genotypes, rare inherited prothromboticrisk factors, i.e. deficiencies of protein C,protein S, and antithrombin, plasminogen, probably inherited risk factors, i.e. fibrinogen, factor VIIIC, factor XII, new candidates, i.e. elevation of lipoprotein (a),and fasting homocysteine concentrations (3-6 months after thrombotic onset). Data interpretation is based on age-dependent reference ranges or the identification of causative gene mutations/polymorphisms with respect to individual ethnic backgrounds.
Nowak-Göttl
Ulrike
U
Paediatric Haematology/Oncology Univ. children's hospital Münster, Germany. leagottl@uni-muenster.de
Duering
Christine
C
Kempf-Bielack
Beate
B
Sträter
Ronald
R
D002648:Child; D005820:Genetic Testing; D006801:Humans; D007231:Infant, Newborn; D012307:Risk Factors; D013923:Thromboembolism / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*