Protection of inactivated influenza virus vaccine against lethal influenza virus infection in diabetic mice.
Influenza virus infection frequently causes complications and some excess mortality in the patients with diabetes. Vaccination is an effective measure to prevent influenza virus infection. In this paper, antibody response and protection against influenza virus infection induced by vaccination were studied in mouse model of diabetes. Healthy and diabetic BALB/c mice were immunized once or twice with inactivated influenza virus vaccine at various dosages. Four weeks after the first immunization or 1 week after the second immunization, the mice were challenged with influenza virus at a lethal dose. The result showed that the antibody responses in diabetic mice were inhibited. Immunization once with high dose or twice with low dose of vaccine provided full protection against lethal influenza virus challenge in diabetic mice, however, in healthy mice, immunization only once with low dose provided a full protection.
Zhu
Qiang
Q
College of Life Science, Hunan Normal University, Changsha, 410081 Hunan, People's Republic of China.
Chang
Haiyan
H
Chen
Yan
Y
Fang
Fang
F
Xue
Changyong
C
Zhang
Fenghua
F
Qiu
Meizhen
M
Wang
Hanzhong
H
Wang
Bin
B
Chen
Ze
Z
D000818:Animals; D001835:Body Weight; D002460:Cell Line; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000821:virology*; D004285:Dogs; D005260:Female; D007074:Immunoglobulin G / Q000378:metabolism; D007252:Influenza Vaccines / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009975:Orthomyxoviridae / Q000378:metabolism*; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D013997:Time Factors
D007074:Immunoglobulin G; D007252:Influenza Vaccines