Different expression of brain-derived neurotrophic factor in the nucleus accumbens of alcohol-preferring (P) and -nonpreferring (NP) rats.
Recent studies suggest that the gene that encodes brain-derived neurotrophic factor (BDNF) might be linked with vulnerability to alcohol abuse. We have now compared BDNF protein levels in several brain regions between alcohol-naive alcohol-preferring (P) and -nonpreferring (NP) rats using the enzyme-linked immunosorbent assay (ELISA) procedure. The results showed that BDNF levels in the nucleus accumbens of the P rats were significantly lower than those of the NP rats, suggesting that this innate difference may contribute to the disparate alcohol drinking behavior of the P and NP rats.
Yan
Qing-Shan
QS
Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA. QSY@UIC.EDU
Feng
Mei-Jiang
MJ
Yan
Shu-E
SE
D000428:Alcohol Drinking / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats
D019208:Brain-Derived Neurotrophic Factor