title: A novel leucodystrophy in a dog.
abstract: A diffuse, bilaterally symmetrical leucoencephalopathy was observed in a 2-month-old female crossbred puppy with a clinical history of progressive tetraparesis with front limb hypermetria, head tremor and seizures. Severe myelinolytic lesions with significant macrophage infiltration were confined to the white matter, mainly of the cerebellum and spinal cord. Moderate loss of myelin with severe gliosis predominated in the cerebrum. Axonal degeneration and axonal loss accompanied myelin degeneration. This disease was classified as a leucodystrophy. The clinical signs and certain features of the lesions (morphology and distribution), differed from those in previously described degenerative myelinolytic diseases in animals. The possible occurrence of the disorder in a littermate suggested a genetic basis.
authors.affiliation: NeuroCenter, Department of Clinical Veterinary Medicine, University of Berne, Bremgartenstrasse 109A, 3001 Berne, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Sisó
authors.forename: C
authors.initials: C
authors.lastname: Botteron
authors.forename: A
authors.initials: A
authors.lastname: Muhle
authors.forename: M
authors.initials: M
authors.lastname: Vandevelde
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology; D003711:Demyelinating Diseases / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D007211:Indoles; D009186:Myelin Sheath / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology; D013194:Staining and Labeling / Q000662:veterinary; D013687:Telencephalon / Q000378:metabolism / Q000473:pathology
chemical_list: D007211:Indoles; C018588:Luxol Fast Blue MBS