New prodiginines from a ketosynthase swap.
The prodiginine antibiotics exhibit antitumor and immunosuppressive activity. In this issue of Chemistry & Biology, Reynolds and coworkers demonstrate that new prodiginines can be obtained by substituting a FabH ketosynthase for the RedP ketosynthase in the undecylprodiginine biosynthetic gene cluster.
Parry
Ronald J
RJ
Department of Chemistry, Rice University, Houston, Texas 77005, USA.
D000123:Acetyltransferases / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D054889:Fatty Acid Synthase, Type II; D009097:Multienzyme Complexes / Q000378:metabolism*; D010860:Pigments, Biological / Q000096:biosynthesis; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000096:biosynthesis; D048372:Streptomyces coelicolor / Q000201:enzymology*
D000900:Anti-Bacterial Agents; D009097:Multienzyme Complexes; D010860:Pigments, Biological; C010307:prodiginine; D000123:Acetyltransferases; D054889:Fatty Acid Synthase, Type II; D011353:Prodigiosin