[Soft tissue sarcomas in Mantua: epidemiological evidence and perspectives for environmental remediation].
Subsequently to the report by a general practitioner of an apparent cluster of soft tissue sarcomas (STS) in thepopulation resident in the neighbourhood of Mantua chemical industries, two independent epidemiological studies (an incidence study and a case-control study) confirmed the original observation and extended the findings in a wider time-span. The two studies are reviewed in the present paper in order to analyze concordant and diverging findings. In the light of the available evidence, recommendations for further studies are presented and perspectives of environmental remediation are discussed.
Comba
Pietro
P
Istituto superiore di sanità, Dipartimento ambiente e connessa prevenzione primaria, Roma. comba@iss.it
Fazzo
Lucia
L
Berrino
Franco
F
D001572:Benzofurans / Q000009:adverse effects; D016022:Case-Control Studies; D002617:Chemical Industry; D000072338:Dibenzofurans, Polychlorinated; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects; D012509:Sarcoma / Q000139:chemically induced / Q000453:epidemiology*; D012983:Soft Tissue Neoplasms / Q000139:chemically induced / Q000453:epidemiology*
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D000072317:Polychlorinated Dibenzodioxins