title: Preventive vaccination of lactating and pregnant heifers against lungworm: safety and protection in three dairy herds.
abstract: A study of the safety of a vaccine against lungworm was carried out with pregnant and lactating heifers from three dairy herds with a previous history of lungworm outbreaks in adult cows. Half of the heifers were vaccinated while the other half were not. A slight temporary cough following the vaccination was only observed in one herd. No adverse effects on pregnancy or milk production were seen. All heifers were serologically and coprologically examined before the first, before and after the second immunization, 3 months after introduction to pasture and at the end of the grazing season. Serological and faecal examination of the dairy cows before introduction into pasture confirmed the presence of at least one Dictyocaulus viviparus carrier in each herd. Lungworm infection occurred in all herds during the grazing season, most prominently in the herd with the highest number of heifers. In this herd, mild coughing associated with the lungworm infection was noticed, especially in the non vaccinated heifers. No other signs or symptoms were observed. It is concluded that a vaccine against D. viviparus can be used safely in heifers, before they are introduced into the adult herd, and that this vaccine can be used as a preventive measure against lungworm outbreaks in adult cattle.
authors.affiliation: GD Ltd., P.O. Box 9, 7400AA Deventer, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Holzhauer
authors.forename: W G
authors.initials: WG
authors.lastname: Holland
authors.forename: H W
authors.initials: HW
authors.lastname: Ploeger
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000188:drug therapy / Q000517:prevention & control*; D003612:Dairying / Q000379:methods*; D004021:Dictyocaulus / Q000276:immunology* / Q000302:isolation & purification; D004022:Dictyocaulus Infections / Q000097:blood / Q000188:drug therapy / Q000517:prevention & control*; D019468:Disease Management; D005243:Feces / Q000469:parasitology; D005260:Female; D007774:Lactation; D008168:Lung / Q000469:parasitology / Q000473:pathology; D008892:Milk / Q000378:metabolism; D009426:Netherlands; D006109:Poaceae; D011247:Pregnancy; D014611:Vaccination / Q000592:standards / Q000662:veterinary*
chemical_list: D000909:Antibodies, Helminth