Immunomodulation by polyunsaturated fatty acids: impact on T-cell signaling.
In recent years the potential application of the immunomodulatory effects of polyunsaturated FA (PUFA), particularly those of the n-3 series, in a variety of inflammatory disorders has been of considerable interest. However, the mechanisms underlying inhibition of T-cell activation have so far been unclear. In this short review we summarize possible mechanisms for the modulation of immune responses by PUFA. Effects of PUFA on T-cell signal transduction pathways and underlying molecular mechanisms are described in detail. These recent results add considerably to the understanding of mechanisms of PUFA actions, but their relevance in the in vivo situation must still be elucidated.
Stulnig
Thomas M
TM
Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria. Thomas.Stulnig@meduniwien.ac.at
Zeyda
Maximilian
M
D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology; D021962:Membrane Microdomains / Q000737:chemistry; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000737:chemistry / Q000187:drug effects / Q000276:immunology*
D005231:Fatty Acids, Unsaturated; D007155:Immunologic Factors
J Cell Biol. 1998 Nov 2;143(3):637-44
9813086
Endocr Rev. 1999 Oct;20(5):649-88
10529898
Atherosclerosis. 1997 Jun;131(2):219-28
9199275
J Immunol. 2003 Jun 15;170(12):6033-9
12794131
Science. 1972 Feb 18;175(4023):720-31
4333397
J Biol Chem. 2003 Sep 26;278(39):37041-51
12865424
J Immunol. 2004 Nov 15;173(10):6151-60
15528352
J Biol Chem. 2000 Jun 9;275(23):17221-4
10770957
J Biol Chem. 2001 Oct 5;276(40):37335-40
11489905
J Biol Chem. 2000 Feb 18;275(7):4541-4
10671476
J Biol Chem. 2002 Aug 9;277(32):28418-23
12029091
Nature. 1997 Jun 5;387(6633):569-72
9177342
Am J Pathol. 1998 Jul;153(1):17-23
9665460
Br J Nutr. 2002 Jan;87 Suppl 1:S31-48
11895154
Int Arch Allergy Immunol. 2003 Dec;132(4):310-21
14707462
J Biol Chem. 2001 Aug 17;276(33):30987-94
11423543
Thromb Res. 1983 Jul 15;31(2):211-7
6314583
J Infect Dis. 2000 Sep;182 Suppl 1:S54-61
10944484
Trends Cell Biol. 2002 Feb;12(2):65-71
11849969
J Nutr. 2003 Jun;133(6):1913-20
12771339
Curr Opin Immunol. 2003 Jun;15(3):255-60
12787749
N Engl J Med. 1986 Apr 10;314(15):937-42
3007982
Science. 2000 Dec 15;290(5499):2140-4
11118147
Cell. 2003 Nov 14;115(4):377-88
14622593
J Immunol. 2000 Feb 1;164(3):1364-71
10640751
Ann Nutr Metab. 1997;41(4):203-34
9363294