[Effect of Rhizoma pinelliae on vomiting in minks].
OBJECTIVE
To study emetic and anti-emetic effects of Rhizoma pinelliae in minks.


METHODS
The emetic effect of raw pinellia 2 g kg(-1) (i.g.) was investigated. Three preparations of Rhizoma pinelliae (processed with ginger) were made by ethanol extraction, water extraction and water decoction respectively and their effects on emesis model induced by cisplatin (7.5 mg kg(-1), i.p.) or apomorphine (1.6 mg kg(-1), s.c.) were then studied; the effect of the decoction of ginger-processed Rhizoma pinelliae on rotation-induced emesis model in minks was also observed.


RESULTS
The emesis was induced by raw pinellia in minks (P < 0.01); ginger-processed Rhizoma pinelliae, metoclopramide and ondansetron significantly inhibit the emesis induced by cisplatin and apomorphine (P < 0.05).


CONCLUSIONS
Ginger-processed Rhizoma pinelliae exhibits a anti-emetic effect in minks, which may be mediated by inhibiting the function of the vomiting center in central nervous system.
Zhao
Yong-juan
YJ
Department of Pharmacology, Medical College of Qingdao University, Qingdao 266021, China.
Ji
Zhong-qiang
ZQ
Zhang
Xiang-nong
XN
Zhang
Yuan-yuan
YY
Wu
Jing-fen
JF
Fang
Xuan
X
Yue
Wang
W
D000818:Animals; D000932:Antiemetics / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D020939:Zingiber officinale; D006358:Hot Temperature; D008297:Male; D008907:Mink; D008517:Phytotherapy; D030021:Pinellia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
D000932:Antiemetics; D004365:Drugs, Chinese Herbal