title: Patenting humans: clones, chimeras, and biological artifacts.
abstract: The momentum of advances in biology is evident in the history of patents on life forms. As we proceed forward with greater understanding and technological control of developmental biology there will be many new and challenging dilemmas related to patenting of human parts and partial trajectories of human development. These dilemmas are already evident in the current conflict over the moral status of the early human embryo. In this essay, recent evidence from embryological studies is considered and the unbroken continuity of organismal development initiated at fertilization is asserted as clear and reasonable grounds for moral standing. Within this frame of analysis, it is proposed that through a technique of Altered Nuclear Transfer, non-organismal entities might be created from which embryonic stem cells could be morally procured. Criteria for patenting of such non-organismal entities are considered.
authors.affiliation: Stanford University, Program in Human Biology, Building 80, Stanford, CA 94305-2160, USA. ethics@stanford.edu
authors.forename: William B
authors.initials: WB
authors.lastname: Hurlbut
mesh_terms: D001675:Bioethics; D002678:Chimera; D019976:Cloning, Organism / Q000941:ethics / Q000331:legislation & jurisprudence; D033041:Embryo Research / Q000941:ethics / Q000331:legislation & jurisprudence; D006801:Humans; D009014:Morals; D010330:Patents as Topic / Q000331:legislation & jurisprudence
references.citation: Nature. 2001 Jan 25;409(6819):517-21
references.pmid: 11206548
references.citation: Development. 2001 Mar;128(6):839-47
references.pmid: 11222139
references.citation: Nature. 2002 Jul 4;418(6893):14-5
references.pmid: 12097880
references.citation: Int J Dev Biol. 1998;42(7):917-25
references.pmid: 9853822
references.citation: Hum Reprod. 2001 Feb;16(2):333-6
references.pmid: 11157829