Perspectives for cytokine antagonist therapy in COPD.
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease associated with progressive airflow limitation. The main risk factor is tobacco smoking. Anti-inflammatory therapies (e.g. corticosteroids) are based on those developed initially for asthma. In contrast to asthma, they are rather ineffective in improving chronic symptoms and reducing inflammation and lung function decline. Specific drugs need to be developed directed against this chronic inflammation, thereby preventing lung tissue damage. Cytokine antagonists for tumour necrosis factor alpha, interleukin 8 receptor, interleukin 1, and specific signal transduction inhibitors have proven to be effective for other inflammatory diseases. Their efficacy for COPD therapy has yet to be demonstrated.
de Boer
Willem I
WI
Netherlands Asthma Foundation, P.O. Box 5, 3830AA, Leusden, The Netherlands. deboer.pim.hetnet.nl
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000037:antagonists & inhibitors*; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000503:physiopathology
D000893:Anti-Inflammatory Agents; D016207:Cytokines