A clonal dic(16;21)(p13.1;p11.2)del(16)(q11.1), with gains of several chromosomes and monosomy 21, in a case of splenic hamartoma: evidence for its neoplastic, not hamartomatous, origin.
Cytogenetic examination of a case of splenic hamartoma led to the discovery of a clonal population with the karyotype 47 approximately 58,XX,+X,+4,+5,+5,+6,+10,+12,+14,der(16)dic(16;21)(p13.3;p11.2), dic(16;21)del(16)(q11.1),+17,+19,+20,-21. This finding is indicative of a neoplastic, not hamartomatous, origin for this lesion.
Donner
Ludvik R
LR
Department of Pathology, Scott and White Memorial Hospital and Clinic, The Texas A and M University System Health Science Center College of Medicine, 2401 South 31st Street, Temple, TX 76508, USA. ldonner@swmail.sw.org
Marcussen
Sandra
S
Dobin
Sheila M
SM
D000368:Aged; D000782:Aneuploidy; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006222:Hamartoma / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D009006:Monosomy; D013160:Splenic Neoplasms / Q000235:genetics* / Q000473:pathology