title: Tricalcium-phosphate and hydroxyapatite bone-graft extender for use in impaction grafting revision surgery. An in vitro study on human femora.
abstract: Impacted morsellised allografts have been used successfully to address the problem of poor bone stock in revision surgery. However, there are concerns about the transmission of pathogens, the high cost and the shortage of supply of donor bone. Bone-graft extenders, such as tricalcium phosphate (TCP) and hydroxyapatite (HA), have been developed to minimise the use of donor bone. In a human cadaver model we have evaluated the surgical and mechanical feasibility of a TCP/HA bone-graft extender during impaction grafting revision surgery. A TCP/HA allograft mix increased the risk of producing a fissure in the femur during the impaction procedure, but provided a higher initial mechanical stability when compared with bone graft alone. The implications of the use of this type of graft extender in impaction grafting revision surgery are discussed.
authors.affiliation: Vrije Universiteit Medical Centre, Amsterdam, The Netherlands.
authors.forename: E H
authors.initials: EH
authors.lastname: van Haaren
authors.forename: T H
authors.initials: TH
authors.lastname: Smit
authors.forename: K
authors.initials: K
authors.lastname: Phipps
authors.forename: P I J M
authors.initials: PI
authors.lastname: Wuisman
authors.forename: G
authors.initials: G
authors.lastname: Blunn
authors.forename: I C
authors.initials: IC
authors.lastname: Heyligers
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000379:methods; D015519:Bone Density; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002102:Cadaver; D002130:Calcium Phosphates / Q000627:therapeutic use*; D017886:Durapatite / Q000627:therapeutic use*; D004548:Elasticity; D005269:Femur / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008422:Materials Testing / Q000379:methods; D011184:Postoperative Period; D012086:Reoperation; D018709:Statistics, Nonparametric; D013314:Stress, Mechanical
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D017886:Durapatite; C018392:tricalcium phosphate