1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.
4-Sulfonyl analogs of 1-(1-naphthyl)piperazine bind at human 5-HT6 receptors and represent a novel class of human 5-HT6 receptor ligands.
Lee
Mase
M
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
Rangisetty
Jagadeesh B
JB
Pullagurla
Manik R
MR
Dukat
Małgorzata
M
Setola
Vince
V
Roth
Bryan L
BL
Glennon
Richard A
RA
D008024:Ligands; D008956:Models, Chemical; D015394:Molecular Structure; D010879:Piperazines / Q000737:chemistry* / Q000494:pharmacology; D011485:Protein Binding; D011985:Receptors, Serotonin / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000737:chemistry / Q000494:pharmacology
D008024:Ligands; C419803:N1-benzenesulfonyl-5-methoxy-N,N-dimethyltryptamine; D010879:Piperazines; D011985:Receptors, Serotonin; D014363:Tryptamines; C097216:serotonin 6 receptor; C048241:1-(1-naphthyl)piperazine