[Usefulness of chemotherapy associated with surgery in the management of nontuberculous mycobacterial adenitis].
BACKGROUND
In recent years, lymphadenitis caused by atypical mycobacteria (also called nontuberculous mycobacteria [NTMB] or, more recently, environmental) have played a significant role in the differential diagnosis of adenitis in non-immunocompromised children.


OBJECTIVE
To describe the clinical and pathological findings in childhood NTMB adenitis and study the possible usefulness of antimicrobial therapy in addition to surgery.


METHODS
We present eight cases of neck lymphadenitis occurring over a 5-year period. All of the children received combined chemotherapy, and six also underwent surgery. Of the two remaining patients, the parents of one child refused surgery and a watchful approach was adopted in the other.


RESULTS
Complete clinical recovery was achieved in all patients except one who did not undergo surgery.


CONCLUSIONS
Prolonged administration of two antibiotics (of which one must be clarithromycin) in addition to surgery was well-tolerated and could be useful in patients with NTMB neck lymphadenitis.
Sanz Santaeufemia
F J
FJ
Centro de Salud Baviera, Area 2, Instituto Madrileño de la Salud, Madrid, Spain.
Ramos Amador
J T
JT
Giangaspro
E
E
Sánchez Granados
J M
JM
Palenque
E
E
González Tomé
M I
MI
D002675:Child, Preschool; D002939:Ciprofloxacin / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D008199:Lymphadenitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D012189:Retrospective Studies
D002939:Ciprofloxacin; D017291:Clarithromycin