Effects of clenbuterol on haemocoagulation process in calves.
The aim of this investigation was to study the effects of clenbuterol treatment (1 mug/kg b.w. i.m. for 10 consecutive days) on haemocoagulation process in seven calves. From each animal, blood samples were taken before (basal sample) and 24, 72, 144, 216, 264, 336 and 360 h after the end of treatment and some parameters were evaluated: coagulation process [prothrombin (PTT) and thrombin times (PT)], a complete blood count and plasmatic levels of 3'5'-monophosphatocyclic-adenosine (c-AMP) . A comparison of the values in each time group during the whole course of the experiments shows a significant increase (P < 0.03, P < 0.01) in PT and PTT at 72, 144, 216 and 264 h. Significant increase (P < 0.01) in c-AMP plasma levels were observed at 144, 216 and 264 h. All these values returned to normal levels after 360 h.
Domina
F
F
Department of Veterinary Medicine Science, University of Messina, Polo S.S. Annunziata, 98168 Messina, Italy.
Niutta
P P
PP
Naccari
C
C
Pugliese
A
A
Naccari
F
F
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D002417:Cattle / Q000502:physiology*; D002976:Clenbuterol / Q000494:pharmacology*; D000242:Cyclic AMP / Q000097:blood*; D007273:Injections, Intramuscular / Q000662:veterinary; D010976:Platelet Count / Q000662:veterinary; D011517:Prothrombin Time / Q000662:veterinary; D013918:Thrombin Time / Q000662:veterinary; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D000242:Cyclic AMP; D002976:Clenbuterol