title: Sporadic Creutzfeldt-Jakob disease: a comparison of pathological findings and diffusion weighted imaging.
abstract: To investigate a possible relationship between the severity of pathological and radiological lesions in diffusion-weighted MRI (DWI) we compared DWI findings from 6 sequential brain MRI scans with pathological features of numerous tissue blocks of different cortical and subcortical regions in a case of autopsy-proven sporadic CJD. Whereas DWI and pathological examination revealed multifocal, cortical and deep hyperintensities at corresponding localizations, no correlation between the degree of severity of radiologically visible and pathological damage was found. The characteristic focal involvement and extension of lesions of the cortex and the basal ganglia bilaterally shown by DWI may be an argument for the spreading of the disease per contiguitatem.
authors.affiliation: Dept. of Neurology, Centre Hospitalier Universitaire Vaudois, Route de Bugnon 11, CH-1011 Lausanne, Switzerland. F.Vingerhoets@chuv.hospvd.ch
authors.forename: Heike
authors.initials: H
authors.lastname: Russmann
authors.forename: Francois
authors.initials: F
authors.lastname: Vingerhoets
authors.forename: Judith
authors.initials: J
authors.lastname: Miklossy
authors.forename: Philippe
authors.initials: P
authors.lastname: Maeder
authors.forename: Markus
authors.initials: M
authors.lastname: Glatzel
authors.forename: Adriano
authors.initials: A
authors.lastname: Aguzzi
authors.forename: Julien
authors.initials: J
authors.lastname: Bogousslavsky
mesh_terms: D016923:Cell Death; D007562:Creutzfeldt-Jakob Syndrome / Q000000981:diagnostic imaging / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D005260:Female; D005911:Gliosis / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D011859:Radiography; D011871:Radiology / Q000379:methods; D013997:Time Factors
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