Malettinins B-D: new polyketide metabolites from an unidentified fungal colonist of Hypoxylon Stromata (NRRL 29110).
Malettinins B-D (2-4), three new antimicrobial polyketide-derived metabolites related to the previously reported malettinin A (1), have been obtained from nonsporulating cultures of an isolate of Mycelia sterilia MYC-155 (= NRRL 29110) collected from colonies of Hypoxylon stromata. Malettinins B (2) and C (3) are partially reduced analogues of malettinin A and were identified by analysis of NMR and MS data. Malettinin D (4) is biogenetically similar, but possesses a new ring system, and the structure of 4 was established by single-crystal X-ray diffraction analysis.
Angawi
Rihab F
RF
Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA.
Swenson
Dale C
DC
Gloer
James B
JB
Wicklow
Donald T
DT
D000363:Agaricales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D018360:Crystallography, X-Ray; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009516:New Mexico; D019906:Nuclear Magnetic Resonance, Biomolecular; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005663:Furans; D013141:Spiro Compounds; C499014:malettinin B; C499015:malettinin C; C499016:malettinin D