In vitro activity of the histatin derivative P-113 against multidrug-resistant pathogens responsible for pneumonia in immunocompromised patients.
The in vitro activity of the histatin derivative P-113, alone or combined with eight antibiotics, was investigated against multidrug-resistant strains isolated from clinical specimens of immunocompromised patients with pneumonia. The gram-negative isolates were susceptible to P-113. S. aureus showed less susceptibility. Synergy was demonstrated when P-113 was combined with beta-lactams against gram-negative organisms.
Giacometti
Andrea
A
Institute of Infectious Diseases and Public Health, Università Politecnica dell Marche, Ancona, Italy. anconacmi@interfree.it
Cirioni
Oscar
O
Kamysz
Wojciech
W
D'Amato
Giuseppina
G
Silvestri
Carmela
C
Del Prete
Maria Simona
MS
Licci
Alberto
A
Riva
Alessandra
A
Lukasiak
Jerzy
J
Scalise
Giorgio
G
D024901:Drug Resistance, Multiple, Bacterial; D054808:Histatins; D006801:Humans; D016867:Immunocompromised Host; D008826:Microbial Sensitivity Tests; D018410:Pneumonia, Bacterial / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012471:Salivary Proteins and Peptides / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D020615:Stenotrophomonas maltophilia / Q000187:drug effects*
D054808:Histatins; C488466:P-113D; D012471:Salivary Proteins and Peptides
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8856-61
10922046
Antimicrob Agents Chemother. 1999 Jun;43(6):1317-23
10348745
Antimicrob Agents Chemother. 2001 Dec;45(12):3437-44
11709321
Lancet Infect Dis. 2001 Oct;1(3):156-64
11871492
Clin Microbiol Rev. 2002 Apr;15(2):194-222
11932230
Med Hypotheses. 2004;62(3):367-74
14975505
MMWR Recomm Rep. 2004 Mar 26;53(RR-3):1-36
15048056
J Infect Dis. 2004 Jul 15;190(2):356-64
15216473
Nature. 1987 Aug 6-12;328(6130):478
3614352
J Biol Chem. 1988 Jun 5;263(16):7472-7
3286634
Int J Pept Protein Res. 1990 Mar;35(3):161-214
2191922
J Antimicrob Chemother. 1993 Jun;31(6):919-26
8360129
Experientia. 1993 Dec 15;49(12):1095-7
8270032
Clin Infect Dis. 1998 May;26(5):1182-7
9597250
Crit Rev Oral Biol Med. 1998;9(4):480-97
9825223
Respiration. 1999;66(2):95-109
10202312
Antimicrob Agents Chemother. 1999 Jun;43(6):1379-82
10348756
Antimicrob Agents Chemother. 2001 May;45(5):1367-73
11302797