title: Simultaneous non-destructive determination of two components of combined paracetamol and amantadine hydrochloride in tablets and powder by NIR spectroscopy and artificial neural networks.
abstract: The two components (paracetamol and amantadine hydrochloride) were simultaneously determined in combined paracetamol and amantadine hydrochloride tablets and powder by using near-infrared (NIR) spectroscopy and artificial neural networks (ANNs). The ANN models of three pretreated spectra (first-derivative, second-derivative and standard normal variate (SNV), respectively) were established. The mathematical corrected models of tablets were compared with those of the powder. In the models, the concentrations of paracetamol and amantadine hydrochloride as the active components were determined simultaneously and compared with the results of their separate determination. The parameters that affected the network were studied and the concentrations of the test set samples were predicted. The degree of approximation, a new evaluation criterion of the network was employed to prove the accuracy of the predicted results.
authors.affiliation: College of Chemistry, Jilin University, 2519 Jifang Avenue, Changchun, Jilin 130021, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Dou
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.forename: Yuqiu
authors.initials: Y
authors.lastname: Ren
authors.forename: Ping
authors.initials: P
authors.lastname: Ju
authors.forename: Yulin
authors.initials: Y
authors.lastname: Ren
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D000547:Amantadine / Q000032:analysis*; D004338:Drug Combinations; D008956:Models, Chemical; D016571:Neural Networks, Computer; D011208:Powders; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013607:Tablets
chemical_list: D004338:Drug Combinations; D011208:Powders; D013607:Tablets; D000082:Acetaminophen; D000547:Amantadine