Morphometry demonstrates loss of cortical thickness in cerebral microangiopathy.
OBJECTIVE
To evaluate the role of MR morphometry in the characterization of cerebral microangiopathy (CMA) in relation to clinical and neuropsychological impairment.


METHODS
3D MR images of 27 patients and 27 age-matched controls were morphometrically analysed for regional thickness. The normalized values were related to the patients' clinical and neuropsychological scores. The patients were categorised according to the amount of structural MR signal changes. A ventricle index reflecting internal atrophy was related to MR morphology and cortical thickness as an indicator for external atrophy.


RESULTS
Cortical thickness was significantly reduced in the patients group (3.03 mm +/- 0.26 vs. 3.22 mm +/-0.13 in controls, p=0.001). The severest loss of cortical thickness occurred in severe CMA. Internal and external atrophy evolved in parallel and both showed a significant relationship with structural MR-abnormalities (p<0.05; r=-0.7; r=0.67; r=-0.74, respectively). Neuropsychological performance correlated strongly with the loss of cortical thickness.


CONCLUSIONS
Cortical thickness was identified as the most sensitive parameter to characterize CMA. A strong correlation was found of morphometric parameters to the severity of CMA based on a score derived from T2-weighted MRI. The degree of cortical atrophy was directly related to the degree of neuropsychological impairment. Our findings suggest that the cortical thickness is a valid marker in the structural and clinical characterization of CMA.
Preul
Christoph
C
Max-Planck-Institute of Human Cognitive and Brain Sciences, Stephanstrasse 1a, 04103 Leipzig, Germany. preul@cbs.mpg.de
Lohmann
Gabriele
G
Hund-Georgiadis
Margret
M
Guthke
Thomas
T
von Cramon
D Yves
DY
D000704:Analysis of Variance; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000473:pathology* / Q000503:physiopathology; D003072:Cognition Disorders; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D013223:Statistics as Topic; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed; D018615:Ultrasonography, Doppler, Color / Q000379:methods
D019690:Technetium Tc 99m Exametazime
Neurology. 1996 Mar;46(3):678-81
8618666
Cerebrovasc Dis. 2002;13 Suppl 2:7-10
11901236
Arch Neurol. 2001 Mar;58(3):493-7
11255455
Stroke. 1999 Mar;30(3):556-66
10066852
Cerebrovasc Dis. 2002;13 Suppl 2:58-60
11901245
Cerebrovasc Dis. 2002;13 Suppl 2:48-52
11901243
J Neurosci Methods. 1997 Jul 18;75(1):81-9
9262148
Eur J Neurol. 2000 Jan;7(1):47-54
10809914
Cerebrovasc Dis. 2002;13 Suppl 2:16-20
11901238
Ann Neurol. 1991 Dec;30(6):825-30
1789694
J Neurol Neurosurg Psychiatry. 2002 Jun;72(6):747-51
12023418
Neurology. 1998 Apr;50(4):972-8
9566381
Neuroimage. 2000 Sep;12(3):340-56
10944416
Cerebrovasc Dis. 2001 Aug;12(2):82-90
11490101
Nuklearmedizin. 1995 Apr;34(2):50-6
7761273
Neurobiol Aging. 1996 Jul-Aug;17(4):513-21
8832624
J Nucl Med. 1998 Jan;39(1):147-54
9443754
Beitr Klin Neurol Psychiatr. 1986;54:1-263
3753418
Cerebrovasc Dis. 2002;13 Suppl 2:21-30
11901239
Ann Neurol. 1989 Jan;25(1):61-7
2643919
Stroke. 1996 Aug;27(8):1269-73
8711785
Neuroimage. 2001 Feb;13(2):375-80
11162277
Neuroimage. 2002 Oct;17(2):631-42
12377139
Nuklearmedizin. 1991 Oct;30(5):161-9
1800939
Neuroimage. 2001 May;13(5):801-13
11304077
Pharmacopsychiatry. 1999 Mar;32 Suppl 1:17-24
10338104
Arch Neurol. 1992 Sep;49(9):909-13
1520079
Neuroimage. 2003 Feb;18(2):198-213
12595176
Cerebrovasc Dis. 2002;13 Suppl 2:53-7
11901244
Stroke. 1992 Oct;23 (10 ):1434-8
1412580
Neurology. 2002 Sep 24;59(6):867-73
12297568
Neurology. 2000 Aug 22;55(4):484-89
10953178
Neurology. 1993 Sep;43(9):1683-9
8414012
Stroke. 1997 Mar;28(3):652-9
9056627
J Magn Reson Imaging. 2000 Apr;11(4):445-51
10767074
Neurology. 2002 Jun 11;58(11):1635-41
12058091
Cerebrovasc Dis. 2002;13 Suppl 2:11-5
11901237
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
10860804
Arch Gen Psychiatry. 1990 Mar;47(3):220-3
2306163