title: Associations of soluble intercellular adhesion molecule-1 with carotid atherosclerosis progression.
abstract: Our previous study demonstrated that plasma concentration of high-sensitivity C-reactive protein (hs-CRP) is a marker of carotid atherosclerosis activity. In this study, we investigated whether plasma levels of soluble cell adhesion molecules have potential value to predict atherosclerosis progression. The study included 192 outpatients 40-82 years of age who were treated for traditional risk factor for cardiovascular disease. Patients underwent repeated ultrasonographic evaluation for 53+/-11 months. Severity of atherosclerosis was evaluated by the maximal intimal-medial thickness (max-IMT), plaque number (PN) and plaque score (PS, the sum of all plaque thicknesses). Blood samples were collected for measurement of hs-CRP, soluble intercellular adhesion molecule (sICAM-1) and sP-selectin at the time of baseline examination. The development of atherosclerosis was estimated by the formula: Deltavalue/year=(last value-baseline value)/number of follow-up years. Multivariate linear regression analysis revealed that sICAM-1 was associated with DeltaIMT/year and DeltaPS/year, which was not the case for sP-selectin. sICAM-1 was closely associated with DeltaIMT/year especially in patients with apparent atheromatous plaque. Our results suggested that levels of sICAM-1 might have predictive value of progression of carotid atherosclerosis independently of traditional risk factors and hs-CRP.
authors.affiliation: Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine (A8), 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
authors.forename: Kimito
authors.initials: K
authors.lastname: Kondo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kitagawa
authors.forename: Yoji
authors.initials: Y
authors.lastname: Nagai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamagami
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Hougaku
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D002340:Carotid Artery Diseases / Q000097:blood* / Q000000981:diagnostic imaging* / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors; D012995:Solubility; D018608:Ultrasonography, Doppler
chemical_list: D015415:Biomarkers; D019007:P-Selectin; D018799:Intercellular Adhesion Molecule-1