Changes in the blood lipid-transporting system in rats over the first day of experimental peritonitis.
Changes in the lipid spectrum of blood plasma and composition of high-density lipoproteins in outbred albino rats were studied during early stages of experimental peritonitis. We revealed an increase in lecithin:cholesterol acyltransferase activity, activation of lipolytic production of high-density lipoproteins from very-low-density lipoproteins, and substitution of arachidonic acid in cholesterol esters for dihomo-gamma-linoleic acid 7 h after induction of peritonitis. After 24 h the protein composition and functional activity of high-density lipoproteins was modified and the amount of saturated fatty acids in cholesterol esters increased.
Osochuk
S S
SS
Central Research Laboratory, Department of General and Clinical Biochemistry, Vitebsk State Medical University, Russia.
Konevalova
N Yu
NY
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000097:blood*; D008055:Lipids / Q000097:blood*; D010538:Peritonitis / Q000097:blood*; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood; D051381:Rats; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase