title: Bilateral optic neuropathy and unilateral tonic pupil associated with acute human herpesvirus 6 infection: a case report.
abstract: BACKGROUND
  Human herpesvirus 6 (HHV-6), a widespread virus and causative agent of exanthema subitum in children, has been associated with a number of neurologic disorders including cranial nerve palsies, seizures, encephalitis, meningitis, and multiple sclerosis.
  
  
  METHODS
  A 31-year-old man presented with bilateral optic neuropathy, disc edema, and unilateral tonic pupil, which were found to be associated with acute HHV-6 infection. The patient had been suffering from juvenile diabetes for 5 years. One week after onset of intravenous antiviral therapy with foscarnet, disc edema subsided, and tonic pupil reaction was no longer detectable.
  
  
  CONCLUSIONS
  HHV-6 infection may play a role as a causative agent in patients with optic neuropathy and tonic pupil.
authors.affiliation: Department of Ophthalmology and University Eye Hospital, University of Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany. isabelvelten@web.de
authors.forename: Isabel M
authors.initials: IM
authors.lastname: Oberacher-Velten
authors.forename: Jost B
authors.initials: JB
authors.lastname: Jonas
authors.forename: Anselm
authors.initials: A
authors.lastname: Jünemann
authors.forename: Barbara
authors.initials: B
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D017245:Foscarnet / Q000627:therapeutic use; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D010211:Papilledema / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D019349:Roseolovirus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D015845:Tonic Pupil / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D017245:Foscarnet
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