title: mecA is not involved in the sigmaB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis.
abstract: A lack of sigma(B) activity reduces methicillin resistance in heterogeneous Staphylococcus epidermidis 1057, whereas inactivation of the anti-sigma factor RsbW switched the phenotype to homogeneous expression of resistance. Oxacillin induction of mecA transcription is reduced in a sigma(B)-negative strain. However, mecA is not involved in the switch of expression phenotype.
authors.affiliation: Universitätsklinikum Hamburg-Eppendorf, Zentrum für Klinisch-Theoretische Medizin, Institut für Infektionsmedizin, Martinistr. 52, D-20246 Hamburg, Germany. knobloch@uke.uni-hamburg.de
authors.forename: Johannes K-M
authors.initials: JK
authors.lastname: Knobloch
authors.forename: Sebastian
authors.initials: S
authors.lastname: Jäger
authors.forename: Jörn
authors.initials: J
authors.lastname: Huck
authors.forename: Matthias A
authors.initials: MA
authors.lastname: Horstkotte
authors.forename: Dietrich
authors.initials: D
authors.lastname: Mack
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D016106:Methicillin Resistance; D010068:Oxacillin / Q000494:pharmacology; D010641:Phenotype; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012808:Sigma Factor / Q000502:physiology*; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; C487495:MecA protein, Staphylococcus epidermidis; C079011:SigB protein, Bacteria; D012808:Sigma Factor; D010068:Oxacillin
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