Outcome of pregnancy after organ transplantation: a retrospective survey in Italy.
The number of women who decide to have a child after organ transplantation has increased. We determined the outcomes of 67 pregnancies of women who had undergone kidney, liver or heart transplantation. All recipients had been maintained on immunosuppressive therapy before and during pregnancy. Pregnancy complications at term were observed in 17 out of 67 women (25%), hypertension being the most frequent complication (16.17%). Two transplant rejections were reported. Sixty-eight infants were delivered (including one pair of twins); five women had two pregnancies at term. Twenty-eight miscarriages (29.2%) were recorded. Of these 68 babies (including the pair of twins), 40 (58.8%) were born at term and 28 (41.2%) before term. The babies were followed-up for 2 months to 13 years. According to our previous experience, our study shows that patients who have undergone organ transplantation can give birth to healthy infants as long as they are monitored accurately during pregnancy.
Miniero
Roberto
R
Department Of Paediatrics, University of Turin, Ospedale San Luigi di Orbassano, Reg. Gonzole 10, 10043, Orbassano, Italy. roberto.miniero@unito.it
Tardivo
Irene
I
Curtoni
Emilio Sergio
ES
Bresadola
Fabrizio
F
Calconi
Gilberto
G
Cavallari
Antonino
A
Centofanti
Paolo
P
Filipponi
Franco
F
Franchello
Alessandro
A
Goggi
Claudio
C
La Rocca
Ennio
E
Mammana
Carmelo
C
Nino
Antonio
A
Parisi
Francesco
F
Regalia
Enrico
E
Rosati
Alberto
A
Segoloni
Giuseppe Paolo
GP
Setti
Gisella
G
Todeschini
Paola
P
Tregnaghi
Carla
C
Zanelli
Paola
P
Dall'Omo
Anna Maria
AM
D001724:Birth Weight; D002303:Cardiac Output, Low / Q000401:mortality; D005260:Female; D005865:Gestational Age; D006084:Graft Rejection / Q000453:epidemiology; D016027:Heart Transplantation; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007558:Italy; D016030:Kidney Transplantation; D016031:Liver Transplantation; D008499:Medical Records; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology; D011256:Pregnancy Outcome; D011644:Puerperal Disorders / Q000401:mortality; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
Transplant Proc. 1997 Aug;29(5):2480
9270819
Arch Neurol. 1981 Jan;38(1):70
6257213
Transplantation. 1994 Feb 27;57(4):502-6
8116032
Am J Kidney Dis. 1991 Feb;17(2):127-32
1992653
Am J Obstet Gynecol. 1973 Apr 15;115(8):1100-6
4348000
Hastings Cent Rep. 1990 Jan-Feb;20(1):24-8
2312265
Transplant Proc. 1997 Aug;29(5):2461-6
9270811
Diabetologia. 1995 Nov;38(11):1371-3
8582549
Transplant Proc. 1997 Aug;29(5):2459-60
9270810
Minerva Ginecol. 1998 Nov;50(11):481-6
9882989
Nephrol Dial Transplant. 1996 Jul;11(7):1314-7
8672028
Br J Obstet Gynaecol. 1993 Feb;100(2):122-5
8476801
Transplantation. 1994 Jun 15;57(11):1617-21
8009597
Eur J Pediatr. 1993 Jun;152(6):476-7
8335013
Transplant Proc. 1994 Apr;26(2):855-7
7513477
Transplant Proc. 1997 Aug;29(5):2470-1
9270813
Transplantation. 1999 Feb 15;67(3):490-2
10030303
J Exp Med. 1988 Apr 1;167(4):1479-85
2965739
Am J Obstet Gynecol. 1991 Jun;164(6 Pt 1):1629-33; discussion 1633-4
2048609
Am J Obstet Gynecol. 1988 Aug;159(2):490-9
3044118
Am J Kidney Dis. 1996 Aug;28(2):266-9
8768923
Transplantation. 1991 May;51(5):1052-7
1903221
Hum Reprod. 1998 Mar;13(3):749-57
9572447
Transplant Proc. 1996 Aug;28(4):2111-2
8769170
Transplantation. 1993 Dec;56(6):1372-5
8279005
J Heart Lung Transplant. 1991 Jul-Aug;10(4):499-503
1911792
Arthritis Rheum. 1995 Dec;38(12):1722-32
8849343
Epidemiol Prev. 2000 Jul-Aug;24(4):166-71
11084768
Transplant Proc. 1994 Oct;26(5):2535
7940780
Transplant Proc. 1995 Feb;27(1):1089-90
7878816
J Heart Lung Transplant. 1998 Jul;17(7):698-702
9703235
Transplantation. 1995 Feb 27;59(4):476-9
7878749
Transplantation. 1996 May 27;61(10):1552-3
8633388