Schistosoma japonicum migration through mouse skin compared histologically and immunologically with S. mansoni.
The migration of Schistosoma japonicum and S. mansoni through mouse skin epidermis and dermis was compared by immunofluorescence techniques from 4 to 22 h after infection. At all times, the percentage of parasites detected in the dermis was significantly higher for S. japonicum than for S. mansoni. Thus, S. japonicum migrates more rapidly very early after infection. This agrees with the quicker migration observed previously by this species for later times. Both species expressed antigens related to the cercarial glycocalyx on the parasite body and antigenically detectable elastase in the acetabular glands, at least until 22 h after infection. Bot sets of antigens were also left as "traces" in cercarial migration channels in the skin as well as in skin tissue in the absence of detectable worms or migration channels. The data further substantiate differences between schistosome species in the speed of migration, and suggest that glycocalyx-related antigens and cercarial elastase continue to be expressed for at least 1 day after infection.
Wang
Lin
L
Department of Tropical Hygiene and Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120 , Heidelberg, Germany.
Li
Yong-Long
YL
Fishelson
Zvi
Z
Kusel
John R
JR
Ruppel
Andreas
A
D000818:Animals; D020405:Dermis / Q000469:parasitology; D004817:Epidermis / Q000469:parasitology; D005455:Fluorescent Antibody Technique; D006652:Histological Techniques; D006790:Host-Parasite Interactions; D051379:Mice; D011817:Rabbits; D012549:Schistosoma japonicum / Q000254:growth & development / Q000502:physiology*; D012550:Schistosoma mansoni / Q000254:growth & development / Q000502:physiology*; D012554:Schistosomiasis japonica / Q000469:parasitology; D012555:Schistosomiasis mansoni / Q000469:parasitology; D012867:Skin / Q000469:parasitology*; D013997:Time Factors
J Infect Dis. 1974 Dec;130(6):626-33
4427079
Parasite Immunol. 1990 Jul;12(4):389-401
2205833
Parasitology. 2000 Jul;121 ( Pt 1):49-54
11085224
Exp Parasitol. 1974 Feb;35(1):44-51
4815018
Parasitology. 2003 Feb;126(Pt 2):135-40
12636351
J Infect Dis. 1992 Nov;166(5):1133-8
1402025
Exp Parasitol. 1981 Jun;51(3):341-65
7227486
Parasitology. 1986 Aug;93 ( Pt 1):55-70
3092171
Parasite Immunol. 2001 Oct;23(10):557-65
11696167
Exp Parasitol. 1992 Aug;75(1):87-98
1639166
Ann Trop Med Parasitol. 2004 Jan;98(1):49-57
15000731
Exp Parasitol. 1983 Dec;56(3):358-68
6641894
Trends Parasitol. 2004 May;20(5):221-6
15105022
Exp Parasitol. 1989 Jan;68(1):108-10
2492946
Mol Biochem Parasitol. 1988 Jul;30(1):45-54
3041276
Parasitol Res. 1998;84(4):338-42
9569102
Trends Parasitol. 2004 Sep;20(9):397-400
15324727
J Helminthol. 1995 Mar;69(1):19-25
7622787
Am J Hyg. 1952 Jan;55(1):22-35
14885163
Parasitol Today. 1990 Dec;6(12):393-5
15463281
Trends Parasitol. 2003 Aug;19(8):339-40
12901933
Exp Parasitol. 2002 Oct;102(2):99-108
12706745
Parasitology. 1990 Aug;101 Pt 1:23-6
2122396
Parasitology. 1997 Sep;115 ( Pt 3):237-47
9300461
Comp Biochem Physiol B. 1991;100(3):507-16
1726079
Parasitology. 1978 Jun;76(3):317-26
662413
J Biol Chem. 2000 Dec 8;275(49):38667-73
10993899