Y chromosome microdeletions in infertile males from Andhra Pradesh, South India.
Studies on the frequency of Y chromosome microdeletions were carried out in 70 idiopathic infertile males with normal karyotypes. Genomic DNA was isolated from blood and PCR analysis was carried out with AZFa, AZFb, and AZFc STS markers SY 84, SY 87, SY 127, SY 254, and SY 158 to detect the deletions. In 9/70 (12.8%) subjects AZF deletions were observed. In 4/9 (44.4%) subjects were azoospermic, 4/9 (44.4%) of cases were severe oligozoospermic, and 1/9 (11.1%) cases was oligozoospermic.
Swarna
M
M
Institute of Genetics & Hospital for Genetic Diseases, Begumpet, Hyderabad, 500 016, India.
Babu
S Ramesh
SR
Reddy
P P
PP
D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D056426:Genetic Loci; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007194:India; D007248:Infertility, Male / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D029589:Seminal Plasma Proteins / Q000235:genetics
D005819:Genetic Markers; D029589:Seminal Plasma Proteins