title: Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing.
abstract: The field of epidermal stem cells has dramatically advanced in the last decade, leading to a better understanding of the molecular factors, signalling pathways and cellular events that identify and characterize stem cells, thus revealing their immense potential for therapeutic use. Furthermore, multipotent epidermal stem cells present the major advantage of easy accessibility with the discovery of their specific location within the bulge of the hair follicle. This review focuses on the most recent findings on epidermal stem cells, and their potential role in initial epidermal commitment, differentiation and wound healing processes in the skin.
authors.affiliation: Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. morassom@mail.nih.gov
authors.forename: Maria I
authors.initials: MI
authors.lastname: Morasso
authors.forename: Marjana
authors.initials: M
authors.lastname: Tomic-Canic
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D000078404:Epidermal Cells; D004817:Epidermis / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000502:physiology; D051379:Mice; D013234:Stem Cells / Q000502:physiology*; D014945:Wound Healing
references.citation: Development. 2003 Jun;130(12):2793-808
references.pmid: 12736221
references.citation: Curr Biol. 2003 May 13;13(10):849-53
references.pmid: 12747834
references.citation: Genes Dev. 2003 May 15;17(10):1189-200
references.pmid: 12756224
references.citation: Oncogene. 2003 Jun 5;22(23):3635-44
references.pmid: 12789272
references.citation: J Cell Physiol. 2003 Aug;196(2):245-50
references.pmid: 12811816
references.citation: J Invest Dermatol. 2003 Aug;121(2):231-41
references.pmid: 12880413
references.citation: Surg Technol Int. 2003;11:23-31
references.pmid: 12931279
references.citation: Curr Opin Biotechnol. 2003 Oct;14(5):520-5
references.pmid: 14580583
references.citation: Cell. 1999 Oct 15;99(2):143-53
references.pmid: 10535733
references.citation: Mol Biol Cell. 2000 Feb;11(2):453-66
references.pmid: 10679006
references.citation: J Cell Sci. 2000 Sep;113 ( Pt 17):3051-62
references.pmid: 10934043
references.citation: Cell. 2000 Aug 18;102(4):451-61
references.pmid: 10966107
references.citation: J Cell Biol. 2000 Sep 4;150(5):1149-60
references.pmid: 10974002
references.citation: J Biol Chem. 2000 Oct 13;275(41):32077-88
references.pmid: 10887174
references.citation: Crit Rev Oral Biol Med. 2000;11(4):383-408
references.pmid: 11132762
references.citation: J Invest Dermatol. 2001 Feb;116(2):330-8
references.pmid: 11180011
references.citation: Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3156-61
references.pmid: 11248048
references.citation: EMBO J. 2001 Mar 15;20(6):1215-22
references.pmid: 11250888
references.citation: Curr Biol. 2001 Apr 17;11(8):558-68
references.pmid: 11369200
references.citation: Cell. 2001 May 18;105(4):533-45
references.pmid: 11371349
references.citation: Nat Genet. 2001 Jun;28(2):165-8
references.pmid: 11381265
references.citation: Genes Dev. 2001 Jul 1;15(13):1688-705
references.pmid: 11445543
references.citation: Cell. 1990 Jun 29;61(7):1329-37
references.pmid: 2364430
references.citation: Adv Dermatol. 1989;4:277-99; discussion 300
references.pmid: 2484318
references.citation: Trends Genet. 1992 Feb;8(2):55-61
references.pmid: 1566372
references.citation: Cell. 1993 May 21;73(4):713-24
references.pmid: 8500165
references.citation: Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6786-90
references.pmid: 7688128
references.citation: J Invest Dermatol. 1993 Oct;101(4):600-4
references.pmid: 8409530
references.citation: Genomics. 1993 Oct;18(1):92-9
references.pmid: 8276421
references.citation: Science. 1994 Nov 4;266(5186):819-22
references.pmid: 7973639
references.citation: Cell. 1995 Jan 13;80(1):83-93
references.pmid: 7813021
references.citation: J Cell Biol. 1995 May;129(3):853-65
references.pmid: 7537276
references.citation: J Invest Dermatol. 1996 Jan;106(1):42-8
references.pmid: 8592080
references.citation: J Cell Biol. 1996 Jul;134(1):241-53
references.pmid: 8698818
references.citation: Science. 1997 Apr 4;276(5309):75-81
references.pmid: 9082989
references.citation: Biochem Biophys Res Commun. 1997 Jul 18;236(2):231-8
references.pmid: 9240415
references.citation: Genes Dev. 1997 Nov 1;11(21):2869-82
references.pmid: 9353256
references.citation: Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3902-7
references.pmid: 9520465
references.citation: J Dermatol Sci. 1998 Jul;17(3):167-81
references.pmid: 9697045
references.citation: Mol Cell. 1998 Sep;2(3):305-16
references.pmid: 9774969
references.citation: Exp Dermatol. 1999 Feb;8(1):80-8
references.pmid: 10206725
references.citation: J Cutan Med Surg. 1998 Dec;3 Suppl 1:S1-24-8
references.pmid: 10082604
references.citation: J Invest Dermatol. 1999 Apr;112(4):411-8
references.pmid: 10201522
references.citation: J Invest Dermatol. 1999 Apr;112(4):470-5
references.pmid: 10201531
references.citation: Nature. 1999 Apr 22;398(6729):708-13
references.pmid: 10227293
references.citation: Nature. 1999 Apr 22;398(6729):714-8
references.pmid: 10227294
references.citation: J Cell Sci. 1999 Aug;112 ( Pt 16):2615-29
references.pmid: 10413670
references.citation: N Engl J Med. 1999 Aug 12;341(7):491-7
references.pmid: 10441606
references.citation: N Engl J Med. 1999 Sep 2;341(10):738-46
references.pmid: 10471461
references.citation: Curr Opin Genet Dev. 2001 Aug;11(4):410-7
references.pmid: 11448627
references.citation: Am J Hum Genet. 2001 Sep;69(3):481-92
references.pmid: 11462173
references.citation: Exp Cell Res. 2001 Nov 1;270(2):199-213
references.pmid: 11640884
references.citation: FASEB J. 2001 Nov;15(13):2533-5
references.pmid: 11641260
references.citation: Stem Cells. 2002;20(1):21-31
references.pmid: 11796919
references.citation: Trends Genet. 2002 Feb;18(2):90-5
references.pmid: 11818141
references.citation: J Invest Dermatol. 2002 Feb;118(2):216-25
references.pmid: 11841536
references.citation: Expert Opin Biol Ther. 2002 Feb;2(2):211-8
references.pmid: 11849120
references.citation: Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2965-70
references.pmid: 11867738
references.citation: Nat Cell Biol. 2002 Apr;4(4):E101-8
references.pmid: 11944044
references.citation: Nat Rev Genet. 2002 Mar;3(3):199-209
references.pmid: 11972157
references.citation: Bioessays. 2002 Sep;24(9):789-800
references.pmid: 12210515
references.citation: J Pathol. 2002 Dec;198(4):417-27
references.pmid: 12434410
references.citation: J Biol Chem. 2002 Nov 22;277(47):45195-202
references.pmid: 12228223
references.citation: J Invest Dermatol. 2002 Nov;119(5):1189-95
references.pmid: 12445211
references.citation: J Investig Dermatol Symp Proc. 2002 Dec;7(1):41-5
references.pmid: 12518791
references.citation: Nature. 2003 Mar 20;422(6929):317-22
references.pmid: 12646922
references.citation: J Cell Biol. 2003 Oct 27;163(2):327-37
references.pmid: 14568992
references.citation: Curr Opin Cell Biol. 2003 Dec;15(6):771-7
references.pmid: 14644204
references.citation: J Invest Dermatol. 2003 Nov;121(5):963-8
references.pmid: 14708593
references.citation: Science. 2004 Jan 16;303(5656):359-63
references.pmid: 14671312
references.citation: Genes Dev. 2004 Jan 15;18(2):126-31
references.pmid: 14729569
references.citation: J Clin Invest. 2004 Feb;113(3):390-400
references.pmid: 14755336
references.citation: Antivir Ther. 2003 Dec;8(6):541-54
references.pmid: 14760888
references.citation: Cell. 2004 Mar 19;116(6):769-78
references.pmid: 15035980
references.citation: Nat Biotechnol. 2004 Apr;22(4):411-7
references.pmid: 15024388
references.citation: Dev Cell. 2004 Apr;6(4):454-6
references.pmid: 15068783
references.citation: Am J Surg. 2004 May;187(5A):29S-33S
references.pmid: 15147989
references.citation: Biochem Biophys Res Commun. 2004 Jun 11;318(4):803-13
references.pmid: 15147942
references.citation: J Dermatol. 2004 May;31(5):368-75
references.pmid: 15187303
references.citation: J Invest Dermatol. 2004 Jul;123(1):23-33
references.pmid: 15191538
references.citation: Lancet. 2004 Jul 10-16;364(9429):172-8
references.pmid: 15246730
references.citation: Gene. 2004 Jun 9;334:123-31
references.pmid: 15256262
references.citation: J Neurosci Res. 2004 Aug 15;77(4):475-86
references.pmid: 15264217
references.citation: Int J Dev Biol. 2004;48(2-3):163-70
references.pmid: 15272381
references.citation: Cell. 2004 Sep 3;118(5):635-48
references.pmid: 15339667
references.citation: Proc Natl Acad Sci U S A. 1987 Apr;84(8):2302-6
references.pmid: 2436229
references.citation: Oncogene. 1999 Aug 26;18(34):4870-8
references.pmid: 10490820
references.citation: Cell. 2001 Jan 26;104(2):233-45
references.pmid: 11207364