title: Antimicrobial use and Pseudomonas aeruginosa susceptibility profile in a cystic fibrosis centre.
abstract: The susceptibility patterns of 1315 mucoid and non-mucoid Pseudomonas aeruginosa strains from 224 patients were determined along with antibiotic utilisation in a Cystic Fibrosis Centre from 1993 to 1997. Ceftazidime was the most active agent (86.0% sensitive isolates), followed by piperacillin-tazobactam (81.7%), aztreonam (80.3%), imipenem (80%), piperacillin (76.8%), tobramycin (76.5%), ciprofloxacin (73.7%), ticarcillin (72.4%), ticarcillin-clavulanic acid (70.2%), amikacin (69.5%), netilmicin (56.5%), meropenem (79%) and imipenem (75.5%). The most frequently used compounds were nebulized colistin (mean+/-S.D., 109+/-45 defined daily doses per 1000 patients per day), followed by ciprofloxacin (98+/-8), tobramycin (55+/-9), ceftazidime (31+/-8) and amikacin (55+/-9). The mean antibiotic consumption by our CF patients was 413+/-47 defined daily doses per 1000 patients per day. Trend testing showed a significant decline of susceptibility to aminoglycosides, imipenem and ciprofloxacin, while the susceptibility of P. aeruginosa to piperacillin and ceftazidime was stable.
authors.affiliation: Infectious Diseases Research and Diagnosis Laboratory, Department of Paediatrics, University of Genoa and Clinical Pathology Laboratories, G. Gaslini Research Institute, Children's Hospital, Genoa, Italy. graziana@unige.it
authors.forename: Graziana
authors.initials: G
authors.lastname: Manno
authors.forename: Mario
authors.initials: M
authors.lastname: Cruciani
authors.forename: Luca
authors.initials: L
authors.lastname: Romano
authors.forename: Sara
authors.initials: S
authors.lastname: Scapolan
authors.forename: Massimo
authors.initials: M
authors.lastname: Mentasti
authors.forename: Renata
authors.initials: R
authors.lastname: Lorini
authors.forename: Laura
authors.initials: L
authors.lastname: Minicucci
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D007297:Inpatients; D007558:Italy; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents