Saccharin as a salt former. Enhanced solubilities of saccharinates of active pharmaceutical ingredients.
Saccharin, acting as a weak acid, forms salts with basic APIs and these salts have the desirable property of enhanced water solubility.
Bhatt
Prashant M
PM
School of Chemistry, University of Hyderabad, Hyderabad 500 046, India.
Ravindra
Nittala V
NV
Banerjee
Rahul
R
Desiraju
Gautam R
GR
D003460:Crystallization; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012439:Saccharin / Q000737:chemistry*; D012492:Salts; D012995:Solubility; D014867:Water / Q000737:chemistry
D004364:Pharmaceutical Preparations; D012492:Salts; D014867:Water; D012439:Saccharin