title: Developmental processes and the induction of cardiovascular function: conceptual aspects.
abstract: The epidemiological basis of the developmental origins of disease concept is now widely accepted. The current impetus in research concerns establishing the underlying mechanisms. We discuss the wider biological nature of the phenomenon, with particular reference to 'maternal effects', the processes observed in many species by which the mother can induce phenotypic effects in her offspring. Animal models permit investigation of the induction of cardiovascular phenotypic attributes which resemble pathological effects in humans. We discuss the importance of transitions in aspects of the pre- versus the postnatal environment, with emphasis on nutrition and energy expenditure, and the critical role which the timing of environmental cues plays in inducing effects on the offspring. Coupled with the effects of specific maternal dietary components, the effects on the offspring are argued to involve epigenetic mechanisms. In this review we provide a conceptual framework for synthesising experimental and clinical data, important for considering the impact of the developmental origins concept in a life-course approach to the prevention of cardiovascular disease.
authors.affiliation: Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital Level F (887), Coxford Road, Southampton S016 5YA, UK. m.hanson@soton.ac.uk
authors.forename: Mark A
authors.initials: MA
authors.lastname: Hanson
authors.forename: Peter D
authors.initials: PD
authors.lastname: Gluckman
mesh_terms: D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000196:embryology*; D004032:Diet; D004734:Energy Metabolism; D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D008955:Models, Cardiovascular; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena / Q000502:physiology*
references.citation: Science. 2003 Apr 25;300(5619):606
references.pmid: 12714735
references.citation: Birth Defects Res A Clin Mol Teratol. 2005 Jul;73(7):481-4
references.pmid: 15959889
references.citation: Mol Cell Biol. 2003 Aug;23(15):5293-300
references.pmid: 12861015
references.citation: J Endocrinol. 2003 Aug;178(2):233-45
references.pmid: 12904171
references.citation: Eur J Neurosci. 2003 Aug;18(3):589-600
references.pmid: 12911755
references.citation: Appetite. 2003 Oct;41(2):123-40
references.pmid: 14550310
references.citation: Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R962-70
references.pmid: 12869365
references.citation: J Physiol. 2003 Dec 1;553(Pt 2):637-47
references.pmid: 12949230
references.citation: J Endocrinol. 2004 Jan;180(1):1-16
references.pmid: 14709139
references.citation: Endocrinology. 2004 Feb;145(2):592-603
references.pmid: 14605012
references.citation: J Physiol. 2004 Jan 15;554(Pt 2):497-504
references.pmid: 14578485
references.citation: Nature. 2004 Jan 29;427(6973):411-2
references.pmid: 14749819
references.citation: Neuroscience. 2004;124(3):619-28
references.pmid: 14980732
references.citation: Reprod Toxicol. 2004 May;18(3):399-406
references.pmid: 15082075
references.citation: Trends Endocrinol Metab. 2004 May-Jun;15(4):183-7
references.pmid: 15109618
references.citation: Nat Neurosci. 2004 Aug;7(8):847-54
references.pmid: 15220929
references.citation: Endocrinology. 2004 Sep;145(9):4278-85
references.pmid: 15205376
references.citation: Circulation. 2004 Aug 31;110(9):1097-102
references.pmid: 15326063
references.citation: Science. 2004 Sep 17;305(5691):1733-6
references.pmid: 15375258
references.citation: J Morphol. 2004 Dec;262(3):701-7
references.pmid: 15487000
references.citation: Am J Physiol. 1988 Nov;255(5 Pt 2):R831-8
references.pmid: 3056043
references.citation: Clin Sci (Lond). 1994 Feb;86(2):217-22; discussion 121
references.pmid: 8143432
references.citation: Philos Trans R Soc Lond B Biol Sci. 1995 Nov 29;350(1332):133-41
references.pmid: 8577857
references.citation: J Neurosci. 1996 Jun 15;16(12):3943-9
references.pmid: 8656288
references.citation: J Clin Endocrinol Metab. 1999 Apr;84(4):1263-7
references.pmid: 10199765
references.citation: Lab Invest. 1999 May;79(5):515-27
references.pmid: 10334563
references.citation: J Mol Biol. 1961 Jun;3:318-56
references.pmid: 13718526
references.citation: Nature. 2004 Nov 4;432(7013):53-7
references.pmid: 15525980
references.citation: Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R34-8
references.pmid: 15178540
references.citation: Placenta. 2003 Apr;24 Suppl A:S65-71
references.pmid: 12842416
references.citation: Development. 2000 Oct;127(19):4195-202
references.pmid: 10976051
references.citation: Am J Obstet Gynecol. 2000 Nov;183(5):1301-7
references.pmid: 11084581
references.citation: J Physiol. 2001 Jan 1;530(Pt 1):141-52
references.pmid: 11136866
references.citation: Atherosclerosis. 2001 Jul;157(1):41-7
references.pmid: 11427202
references.citation: Int J Epidemiol. 2001 Oct;30(5):928-34
references.pmid: 11689495
references.citation: Mol Cell Endocrinol. 2001 Dec 20;185(1-2):93-8
references.pmid: 11738798
references.citation: Br Med Bull. 2001;60:5-20
references.pmid: 11809615
references.citation: Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5471-5
references.pmid: 11960003
references.citation: Clin Sci (Lond). 2002 Dec;103(6):633-9
references.pmid: 12444916
references.citation: Am J Clin Nutr. 2003 Mar;77(3):726-30
references.pmid: 12600868
references.citation: Arch Physiol Biochem. 2003 Feb;111(1):8-16
references.pmid: 12715270
references.citation: Arch Physiol Biochem. 2003 Feb;111(1):23-35
references.pmid: 12715272
references.citation: Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R39-45
references.pmid: 15191901
references.citation: Proc Biol Sci. 2005 Apr 7;272(1564):671-7
references.pmid: 15870029
references.citation: J Physiol. 2005 May 15;565(Pt 1):3-8
references.pmid: 15695245