Prenatal corticosteroid therapy for elevated liver enzyme/low platelet count syndrome: a case report.
BACKGROUND
Early preterm onset of elevated liver enzymes/low platelet count (ELLP) syndrome poses a significant management problem.


METHODS
Antepartum methylprednisolone, 40 mg/d intravenously was employed to stabilize ELLP syndrome, to achieve fetal lung maturity and to postpone delivery at 25 weeks and 5 days' gestation. Normalization of the liver transaminases and platelet count occurred with the use of corticosteroids, but sudden fetal death occurred at 28 weeks and 2 days' gestation.


CONCLUSIONS
Prenatal corticosteroids may improve the biochemical and hematologic parameters of ELLP syndrome but may result in intrauterine death.
Qureshi
Najm S
NS
Women's Health Directorate, Royal Bolton Hospital, Minerva Road, Bolton BL4 OJR, UK. nsq@doctors.org.uk
Tomlinson
Anthony J
AJ
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010976:Platelet Count; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011262:Pregnancy Trimester, Second; D000637:Transaminases / Q000187:drug effects*; D016896:Treatment Outcome
D005938:Glucocorticoids; D000637:Transaminases; D008775:Methylprednisolone