title: Spreading depression in vivo potentiates electrically-driven responses in frog optic tectum.
abstract: This is the first description of an in vivo potentiation phenomenon associated to spreading depression (SD) in the frog optic tectum. Field potential responses electrically-elicited from the optic tract and recorded in the optic tectum disappeared during KCl-elicited SD and recovered 10-20 min thereafter. Post-SD responses reached amplitudes 10-30% higher than their pre-SD values (P<0.05), indicating a potentiation effect. Current source density analysis of the tectal depth profiles of field-potential responses, as well as the calculation of the post-SD intratectal conductance changes, also supported the potentiation phenomenon. This in vivo potentiation lasted for 40-90 min, suggesting a post-SD enhancement of synaptic transmission, which may be important in understanding mechanisms of brain disfunctions like epilepsy.
authors.affiliation: Department of Nutrition, Universidade Federal de Pernambuco, BR-50670-901 Recife, PE, Brazil. rguedes@ufpe.br
authors.forename: Rubem Carlos Araújo
authors.initials: RC
authors.lastname: Guedes
authors.forename: Kazuya
authors.initials: K
authors.lastname: Tsurudome
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D013181:Cortical Spreading Depression / Q000502:physiology*; D004558:Electric Stimulation; D004594:Electrophysiology / Q000379:methods; D005260:Female; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D011189:Potassium Chloride; D011892:Rana catesbeiana / Q000033:anatomy & histology / Q000502:physiology*; D013477:Superior Colliculi / Q000033:anatomy & histology / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D014795:Visual Pathways / Q000033:anatomy & histology / Q000502:physiology*
chemical_list: D011189:Potassium Chloride