Enantioselective separations by packed column subcritical and supercritical fluid chromatography.
Enantioselective separations have been one of the most successful applications of supercritical fluid chromatography (SFC). Although analytical scale separations have dominated the literature, the use of SFC for preparative chiral separations is growing. Both analytical and preparative scale SFC separations seek to take advantage of the high efficiency, high throughput, and rapid method development associated with the technique. This review will cover recent developments in the application of SFC to enantioseparations.
Phinney
Karen W
KW
Analytical Chemistry Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899-8392, USA. karen.phinney@nist.gov
D002853:Chromatography, Liquid / Q000379:methods; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
D006841:Hydrocarbons, Aromatic