title: Vessel size imaging in humans.
abstract: The relation of contrast-enhanced transverse relaxation rates R2* and R2 provides in vivo mapping of the mean caliber of cerebral vessels. This technique is referred to as vessel size imaging (VSI). Here a quantitative assessment of the vessel caliber in brain tumor patients is presented. The obtained mean vessel size shows sensitivity to the tumor type. A theoretical analysis is given to elucidate the morphological information content of VSI in the context of vessel architecture. The simplification of the theory underlying the data processing results in a systematic overestimation of the vessel caliber. An increase in the magnetic susceptibility of the contrast agent allows for quantitatively more accurate measurements. Quantitative VSI must include measurements of the regional diffusion coefficient and absolute determination of the regional cerebral blood volume.
authors.affiliation: Medical Physics, Department of Diagnostic Radiology, University Hospital Freiburg, Hugstetterstrasse 55, D-79106 Freiburg, Germany.
authors.forename: V G
authors.initials: VG
authors.lastname: Kiselev
authors.forename: R
authors.initials: R
authors.lastname: Strecker
authors.forename: S
authors.initials: S
authors.lastname: Ziyeh
authors.forename: O
authors.initials: O
authors.lastname: Speck
authors.forename: J
authors.initials: J
authors.lastname: Hennig
mesh_terms: D016880:Anisotropy; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology; D002536:Cerebral Arteries / Q000473:pathology; D002550:Cerebral Veins / Q000473:pathology; D003198:Computer Simulation; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography; D008833:Microcirculation / Q000473:pathology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA