title: Cognitive therapy for persistent psychosis in schizophrenia: a case-controlled clinical trial.
abstract: The results of an open label controlled outcome study are presented, comparing Cognitive Therapy with a treatment-as-usual group. Independent raters assessed symptom severity and psychosocial functioning at baseline, and again at 6 months. Improvements were found for Cognitive Behavior Therapy (CBT) patients in Clinical Global Impression for Improvement (CGI; p<0.03), Global Psychosocial Functioning (p<0.001), the Global Assessment Scale (GAS) ratings (p<0.013), overall symptoms (p<0.049), and delusions (p<0.029). A trend toward significance was found for reductions in negative symptoms (p<0.06). The results suggest the potential utility of cognitive therapy as a companion therapy for schizophrenia in the United States. Limitations of the study include small sample sizes, lack of randomized assignment, and rater nonblindedness to treatment condition.
authors.affiliation: Department of Psychiatry, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 1911 JPP, Iowa City, IA 52242, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Temple
authors.forename: Beng-Choon
authors.initials: BC
authors.lastname: Ho
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000209:etiology* / Q000628:therapy*; D012559:Schizophrenia / Q000150:complications*