ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia.
Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD.
Kölsch
H
H
Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. heike.koelsch@ukb.uni-bonn.de
Jessen
F
F
Freymann
N
N
Kreis
M
M
Hentschel
F
F
Maier
W
W
Heun
R
R
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology / Q000235:genetics*; D004251:DNA Transposable Elements / Q000235:genetics; D015140:Dementia, Vascular / Q000201:enzymology / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A