Effects of methylprednisolone on the neural conduction of the motor evoked potentials in spinal cord injured rats.
Methylprednisolone(MP), a glucocorticoid steroid, has an anti-inflammatory action and seems to inhibit the formation of oxygen free radicals produced during lipid peroxidation in a spinal cord injury(SCI). However, the effects of MP on the functional recovery after a SCI is controversial. The present study was conducted to determine the effects of MP on the recovery of neural conduction following a SCI. A SCI was produced using the NYU spinal cord impactor. A behavioral test was conducted to measure neurological disorders, and motor evoked potentials (MEPs) were recorded. According to the behavioral test, using BBB locomotor scaling, MP-treated animals showed improved functional recoveries when compared to saline-treated animals. MEP latencies in the MP-treated group were shortened when compared to those in the control group. Peak amplitudes of MEPs were larger in the MP-treated group than those in the control group. The thresholds of MEPs tended to be lower in the MP-treated group than those in the control group. These results suggest that MP may improve functional recovery after a SCI.
Lee
Bae Hwan
BH
Department of Neurosurgery, Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Lee
Kyung Hee
KH
Yoon
Do Heum
DH
Kim
Un Jeng
UJ
Hwang
Yong Soon
YS
Park
Sang Keun
SK
Choi
Joong Uhn
JU
Park
Yong Gou
YG
D000818:Animals; D004195:Disease Models, Animal; D004594:Electrophysiology; D019054:Evoked Potentials, Motor / Q000187:drug effects*; D005609:Free Radicals; D005938:Glucocorticoids / Q000378:metabolism; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy*; D013997:Time Factors
D005609:Free Radicals; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D012965:Sodium Chloride; D010100:Oxygen; D008775:Methylprednisolone
J Neurosurg. 1991 Jul;75(1):15-26
2045903
J Neurotrauma. 1990 Fall;7(3):115-9
2258942
Paraplegia. 1993 Jul;31(7):417-29
8371933
Neurosurgery. 1993 Sep;33(3):470-6; discussion 476-7
8413879
Surg Neurol. 1993 Dec;40(6):461-70
8235968
Spine (Phila Pa 1976). 1994 Oct 15;19(20):2321-9; discussion 2330
7846578
J Neurotrauma. 1995 Feb;12(1):1-21
7783230
Physiol Rev. 1996 Apr;76(2):319-70
8618960
Neurol Res. 1997 Jun;19(3):289-99
9192382
Brain Res Mol Brain Res. 1998 Aug 31;59(2):135-42
9729336
Surv Ophthalmol. 1999 Jun;43 Suppl 1:S136-41
10416756
J Neurosurg. 1992 Jan;76(1):13-22
1727150
J Neurotrauma. 1992 Mar;9 Suppl 1:S135-42
1588604
J Neurotrauma. 1993 Spring;10(1):25-35
8320730
J Neurotrauma. 2000 Mar;17(3):203-18
10757326
J Neurosci. 2002 Aug 15;22(16):7111-20
12177207
J Korean Med Sci. 2004 Feb;19(1):113-22
14966352
J Neurosurg. 1974 Jan;40(1):44-51
4808485
Surg Neurol. 1973 Mar;1(2):102-6
4772792
Surg Neurol. 1980 Feb;13(2):91-7
6766574
Proc Natl Acad Sci U S A. 1980 May;77(5):2533-6
6930649
Acta Physiol Scand Suppl. 1980;492:91-119
6939309
J Neurosurg. 1982 Nov;57(5):667-73
7131067
J Neurosurg. 1984 Apr;60(4):712-7
6707740
J Neurosurg. 1984 Jul;61(1):124-30
6374068
Int J Immunopharmacol. 1985;7(6):839-47
3935587
J Neurosurg. 1986 Jul;65(1):92-8
3519891
Cent Nerv Syst Trauma. 1986 Fall;3(4):317-31
3555851
J Neurosurg. 1987 Jul;67(1):102-5
3598657
Clin Neurosurg. 1988;34:675-97
3378379
Annu Rev Neurosci. 1990;13:43-60
2183684
N Engl J Med. 1990 May 17;322(20):1405-11
2278545
Acta Neurol Scand. 1990 Jul;82(1):68-73
2239140
Int J Dev Neurosci. 1993 Jun;11(3):311-24
8356900