"Molecular chameleons". Design and synthesis of a second series of flexible nucleosides.
The second series of flexible shape-modified nucleosides is introduced. The "fleximers" feature the purine ring systems split into their individual imidazole and pyrimidine components. This structural modification serves to introduce flexibility to the nucleoside while still retaining the elements essential for recognition. As a consequence, these structurally innovative nucleosides can more readily adapt to their environment and should find use as bioprobes for investigating enzyme-coenzyme binding sites as well as nucleic acid and protein interactions. Their design and synthesis is described.
Seley
Katherine L
KL
Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA. kseley@umbc.edu
Salim
Samer
S
Zhang
Liang
L
O'Daniel
Peter I
PI
D008956:Models, Chemical; D008968:Molecular Conformation; D018716:Molecular Mimicry; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry
D009705:Nucleosides