title: Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture.
abstract: HTS of the compound collection for inhibition of the HCV RNA dependent RNA polymerase identified two 168 member N-acyl pyrrolidine combinatorial mixture hits. Deconvolution and expansion of these mixtures by solid phase synthesis to establish initial SAR and identify a potent inhibitor is reported.
authors.affiliation: GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, PO Box 5089, Collegeville, PA 19426-0989, USA. george.burton@gsk.com
authors.forename: George
authors.initials: G
authors.lastname: Burton
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Ku
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Carr
authors.forename: Terry
authors.initials: T
authors.lastname: Kiesow
authors.forename: Robert T
authors.initials: RT
authors.lastname: Sarisky
authors.forename: Juili
authors.initials: J
authors.lastname: Lin-Goerke
authors.forename: Audrey
authors.initials: A
authors.lastname: Baker
authors.forename: David L
authors.initials: DL
authors.lastname: Earnshaw
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Hofmann
authors.forename: Richard M
authors.initials: RM
authors.lastname: Keenan
authors.forename: Dashyant
authors.initials: D
authors.lastname: Dhanak
mesh_terms: D020650:Combinatorial Chemistry Techniques; D016174:Hepacivirus / Q000201:enzymology*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry* / Q000494:pharmacology*; D012324:RNA-Dependent RNA Polymerase / Q000037:antagonists & inhibitors*
chemical_list: D011759:Pyrrolidines; D012324:RNA-Dependent RNA Polymerase