Efficacy of mirazid in comparison with praziquantel in Egyptian Schistosoma mansoni-infected school children and households.
This trial investigated the anti-schistosomal activity of mirazid in comparison with that of praziquantel in Schistosoma mansoni-infected Egyptian patients. The sample population was composed of 1,131 individuals (459 school children and 672 household members). Screening for S. mansoni was conducted using the standard Kato Katz technique. Four slides from a single stool sample were examined before treatment, and four slides per sample from stool samples obtained on three consecutive days were examined post-treatment. All positive eligible subjects were randomly assigned into two groups, the first received mirazid at a dose of 300 mg/day for three consecutive days, and the second received praziquantel at a single dose of 40 mg/kg. All treated subjects were examined 4-6 weeks post-treatment. Mirazid showed low cure rates of 9.1% and 8.9% in S. mansoni-infected school children and household members, respectively, compared with cure rates of 62.5% and 79.7%, respectively, in those treated with praziquantel. Therefore, we do not recommend mirazid as an agent to control schistosomiasis.
Botros
Sanaa
S
Theodor Bilharz Research Institute, Warrak El-Hadar, Giza, Egypt. sanaabotros@link.net <sanaabotros@link.net>
Sayed
Hanan
H
El-Dusoki
Howaida
H
Sabry
Hoda
H
Rabie
Ibrahim
I
El-Ghannam
Maged
M
Hassanein
Moataz
M
El-Wahab
Yehia Abd
YA
Engels
Dirk
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D004534:Egypt / Q000453:epidemiology; D005191:Family Characteristics; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000302:isolation & purification; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D012556:Schistosomicides / Q000008:administration & dosage / Q000627:therapeutic use*; D013729:Terpenes / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D012556:Schistosomicides; D013729:Terpenes; D011223:Praziquantel; C014119:myrrh oil