Inhibition of acetylcholinesterase activity by bicyclic monoterpenoids.
Inhibition of acetylcholinesterase (AChE) activity by 17 kinds of bicyclic monoterpenoids was investigated. Bicyclic monoterpenoids are contained in many kinds of essential oils. Inhibition of AChE was measured according to the colorimetric method. 3.1.1 and 4.1.0 bicyclic hydrocarbons with allylic methyl group showed strong inhibition. (+)- and (-)-alpha-pinene and (+)-3-carene were potent inhibitors of AChE. 3.1.1 and 2.2.1 bicyclic alcohols and ketones showed weak inhibition. 3.1.1 and 4.1.0 bicyclic hydrocarbons with allylic methyl group were found to be uncompetitive inhibitors.
Miyazawa
Mitsuo
M
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosakashi, Osaka 577-8502, Japan. miyazawa@apch.kindai.ac.jp
Yamafuji
Chikako
C
D000110:Acetylcholinesterase / Q000378:metabolism*; D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003124:Colorimetry; D007700:Kinetics; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000081008:Bicyclic Monoterpenes; D001643:Bridged Bicyclo Compounds; D002800:Cholinesterase Inhibitors; D039821:Monoterpenes; D000110:Acetylcholinesterase; C030218:3-carene; C005451:alpha-pinene