title: 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.
abstract: 4-Sulfonyl analogs of 1-(1-naphthyl)piperazine bind at human 5-HT6 receptors and represent a novel class of human 5-HT6 receptor ligands.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298-0540, USA.
authors.forename: Mase
authors.initials: M
authors.lastname: Lee
authors.forename: Jagadeesh B
authors.initials: JB
authors.lastname: Rangisetty
authors.forename: Manik R
authors.initials: MR
authors.lastname: Pullagurla
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Dukat
authors.forename: Vince
authors.initials: V
authors.lastname: Setola
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Roth
authors.forename: Richard A
authors.initials: RA
authors.lastname: Glennon
mesh_terms: D008024:Ligands; D008956:Models, Chemical; D015394:Molecular Structure; D010879:Piperazines / Q000737:chemistry* / Q000494:pharmacology; D011485:Protein Binding; D011985:Receptors, Serotonin / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000737:chemistry / Q000494:pharmacology
chemical_list: D008024:Ligands; C419803:N1-benzenesulfonyl-5-methoxy-N,N-dimethyltryptamine; D010879:Piperazines; D011985:Receptors, Serotonin; D014363:Tryptamines; C097216:serotonin 6 receptor; C048241:1-(1-naphthyl)piperazine