Applications of the oral scraped (exfoliative) cytology in oral cancer and precancer.
Scraped (exfoliative) cytology is a simple and harmless procedure, which has been a controversial technique according to its real validity in oral pathology. Lately it has re-emerged due to its application in oral precancer and cancer as a diagnostic and predictive method as well as for monitoring patients. New diagnostic techniques have been developed, such as "brush biopsy" and multiple molecular studies using the cells collected. In this review we are going to analyse the more novel aspects related with the applications of the scraped or exfoliative cytology in oral precancerous and cancerous pathology, specially focusing on molecular studies and their diagnostic and prognostic implications.
Acha
Amelia
A
Medicina Bucal, Unidad de Patología Oral y Maxilofacial, Departamento de Estomatología, Universidad del País Vasco EHU, Leioa, Vizcaya, Spain.
Ruesga
María T
MT
Rodríguez
María J
MJ
Martínez de Pancorbo
María A
MA
Aguirre
José M
JM
D014408:Biomarkers, Tumor / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000235:genetics; D003581:Cytodiagnosis / Q000379:methods*; D020732:Cytogenetic Analysis; D019175:DNA Methylation; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000235:genetics; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53