title: The benefit of chemotherapy in a patient with multiple brain metastases and meningitis carcinomatosa from ovarian cancer.
abstract: We report on a 45-year-old patient with stage IIIc ovarian cancer, multiple brain metastases, and meningitis carcinomatosa. After three courses of initial chemotherapy, consisting of docetaxel and carboplatin, the patient underwent interval cytoreductive surgery, consisting of hyster-ectomy, bilateral salpingo-oophorectomy, omentectomy, appendectomy, and retroperitoneal lymphadenectomy. Then five courses of the same chemotherapy were given as adjuvant treatment. At the completion of the primary therapy, she achieved a complete remission. Ten months after the completion of the initial treatment, multiple brain metastases with meningitis carcinomatosa were detected. After four courses of the same chemotherapy, she again had a complete response, confirmed by cranial enhanced magnetic resonance imaging (MRI), and she felt well, with relief from the debilitating neurologic symptoms for 4 months. After this 4 months, her disease recurred, with meningitis carcinomatosa, and she requested supportive care only. She died 4 months after this recurrence. Chemotherapy can help to prolong life for some patients with multiple brain metastases and meningitis carcinomatosa from ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishimachi, Yonago, 683-8504, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Watanabe
authors.forename: Muneaki
authors.initials: M
authors.lastname: Shimada
authors.forename: Junzo
authors.initials: J
authors.lastname: Kigawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Iba
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Oishi
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Kanamori
authors.forename: Naoki
authors.initials: N
authors.lastname: Terakawa
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D016190:Carboplatin / Q000008:administration & dosage; D002277:Carcinoma / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D000077143:Docetaxel; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008581:Meningitis / Q000188:drug therapy*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D012008:Recurrence; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D016190:Carboplatin