title: Characterization of Opr deficiency in mouse brain: subtle defects in dorsomedial telencephalon and medioventral forebrain.
abstract: Opr/Zic5 is a zinc-finger gene belonging to, and unique in, the opa/Zic family. Its expression is found in the anterior epiblast and anterior neuroectoderm during gastrulation and early neurulation. Later, we found the expression characteristic in the dorsomedial parts of forebrain and midbrain. However, no defects were apparent in embryonic day 10.5 Opr null mutants, and subtle defects were later found in medial pallium and ventral structures of forebrain, suggesting the compensation of Opr deficiency by its cognate(s).
authors.affiliation: Laboratory for Animal Resources and Genetic Engineering, Center for Developmental Biology (CDB), RIKEN Kobe, Kobe, Japan.
authors.forename: Kenryo
authors.initials: K
authors.lastname: Furushima
authors.forename: Takuya
authors.initials: T
authors.lastname: Murata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyonari
authors.forename: Shinichi
authors.initials: S
authors.lastname: Aizawa
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics*; D004268:DNA-Binding Proteins; D017353:Gene Deletion; D051379:Mice; D008817:Mice, Mutant Strains; D013687:Telencephalon / Q000196:embryology* / Q000473:pathology; D014157:Transcription Factors
chemical_list: D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D014157:Transcription Factors; C418623:Zic5 protein, mouse