title: Massive myeloid sarcoma affecting the central nervous system, mediastinum, retroperitoneum, liver, and rectum associated with acute myeloblastic leukaemia: a case report.
abstract: Myeloid sarcomas are extramedullary tumours with granulocytic precursors. When associated with acute myelogenous leukaemia (AML), these tumours usually affect no more than two different extramedullary regions. This report describes a myeloid sarcoma associated with AML with tumour formation at five anatomical sites. The patient was a 37 year old man admitted in September 1999 with a two month history of weight loss, symptoms of anaemia, rectal bleeding, and left facial nerve palsy. The anatomical sites affected were: the rectum, the right lobe of the liver, the mediastinum, the retroperitoneum, and the central nervous system. A bone marrow smear was compatible with AML M2. Flow cytometry showed that the peripheral blood was positive for CD4, CD11, CD13, CD14, CD33, CD45, and HLA-DR. A karyotypic study of the bone marrow revealed an 8;21 translocation. The presence of multiple solid tumours in AML is a rare event. Enhanced expression of cell adhesion molecules may be the reason why some patients develop myeloid sarcomas.
authors.affiliation: Departmento de Hematologia, Hospital General de Occidente, SSJ, Zapopan, Jalisco, 45170 México. bestvme@cencar.udg.mx
authors.forename: C R
authors.initials: CR
authors.lastname: Best-Aguilera
authors.forename: M
authors.initials: M
authors.lastname: Vazquez-Del Mercado
authors.forename: J F
authors.initials: JF
authors.lastname: Muñoz-Valle
authors.forename: L
authors.initials: L
authors.lastname: Herrera-Zarate
authors.forename: R E
authors.initials: RE
authors.lastname: Navarro-Hernandez
authors.forename: B T
authors.initials: BT
authors.lastname: Martin-Marquez
authors.forename: E
authors.initials: E
authors.lastname: Oregon-Romero
authors.forename: S
authors.initials: S
authors.lastname: Ruiz-Quezada
authors.forename: G M
authors.initials: GM
authors.lastname: Bonilla
authors.forename: A
authors.initials: A
authors.lastname: Lomeli-Guerrero
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D023981:Sarcoma, Myeloid / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
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