title: Longicalycinin A, a new cytotoxic cyclic peptide from Dianthus superbus var. longicalycinus (MAXIM.) WILL.
abstract: A new cyclic peptide, longicalycinin A (1), and six known compounds, vaccaroside A, dianoside A, dianoside G, 3-(4-hydroxy-3-methoxy-phenyl)propionic acid methyl ester, p-hydroxybenzoic acid, and p-hydroxybenzaldehyde were isolated from the MeOH extract of Dianthus superbus var. longicalycinus. The amino acid sequences of 1 was elucidated as cyclo(Gly(1)-Phe(2)-Tyr(3)-Pro(4)-Phe(5)-) on the basis of ESI tandem mass fragmentation analysis, chemical evidence, and extensive 2D NMR methods. Furthermore, compound 1 showed cytotoxicity to Hep G2 cancer cell line.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan.
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Hsieh
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Ching-Chung
authors.initials: CC
authors.lastname: Wu
authors.forename: Chien-Ming
authors.initials: CM
authors.lastname: Li
authors.forename: Kuen-Yuh
authors.initials: KY
authors.lastname: Wu
authors.forename: Su-Li
authors.initials: SL
authors.lastname: Chen
authors.forename: Hsin-Fu
authors.initials: HF
authors.lastname: Yen
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D045744:Cell Line, Tumor; D029749:Dianthus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010456:Peptides, Cyclic; C502855:longicalycinin A