Selenoureas and thioureas are effective superoxide radical scavengers in vitro.
Oxygen radicals, such as superoxide radicals, embellishing DNA, protein, lipids, etc., and carrying out the obstacle of the function of a cell is known. It depends for the oxidant level in the living body on the balance of a generation system and an elimination system of oxygen radicals, and research which controls an oxidant level in the living body is briskly done by taking in the substance which eliminates an oxygen radical. We investigated scavenging effects of superoxide radicals by selenoureas and thioureas using a highly sensitive and quantitative chemiluminescence method. At 330 nM, five selenoureas and five thioureas scavenged fractions of superoxide radicals (O2-) ranging from 8.4% to 87.6%. Among five N,N-unsubstituted selenoureas and N,N-unsubstituted thioureas 1-selenocarbamoylpiperidine and 1-thiocarbamoylpyrrolidine were the most effective scavengers. A possibility that selenoureas could use it as a new superoxide anion-scavenging substance from the result of this research became clear.
Takahashi
Hitoe
H
Gunma Industrial Technology Center, 884-1 Kamesato, Maebashi, Gunma, 379-2147, Japan.
Nishina
Atsuyoshi
A
Fukumoto
Ryo-hei
RH
Kimura
Hirokazu
H
Koketsu
Mamoru
M
Ishihara
Hideharu
H
D004305:Dose-Response Relationship, Drug; D049454:Firefly Luciferin / Q000737:chemistry; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry*; D007202:Indicators and Reagents; D016566:Organoselenium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry; D013481:Superoxides / Q000737:chemistry*; D013890:Thiourea / Q000138:chemical synthesis / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*
D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D016566:Organoselenium Compounds; D016877:Oxidants; D017382:Reactive Oxygen Species; C081959:selenourea; D013481:Superoxides; D049454:Firefly Luciferin; D014508:Urea; D013890:Thiourea