title: A forgotten old disease: mediastinal tuberculous lymphadenitis in children.
abstract: OBJECTIVE
  The purpose of the study was two-fold: (1) to highlight the varied presentation of mediastinal tuberculous lymphadenitis (MTL) in children and (2) to identify parameters, that may help in the early diagnosis of this condition.
  
  
  METHODS
  Between January 1995 and December 2002, 13 children with histological diagnosis of MTL were retrospectively assessed for age at presentation, history of exposure to TB, presenting symptoms, investigations, initial diagnosis, surgical treatment and outcome. Stepwise multiple linear regression analysis was used to determine potential risk factors for early diagnosis of MTL.
  
  
  RESULTS
  Thirteen children presented with: (a) fever, night sweats and weight loss (4); (b) acute respiratory distress (2); (c) cough and shortness of breath (SOB) (5); (d) stridor (1); and (e) chest pain (1). TB was suspected only in 6 children (46%) at presentation. In the other 7 cases (54%) the presumed diagnoses were: neuroblastoma (n=1), metastatic malignancy (n=1), bronchial polyp (n=1), bronchogenic cyst (n=2), and presumed foreign body (n=2). Bronchoscopy was diagnostic in identifying cheesy material within the bronchus and organisms on lavage in 4 (30%) and in identifying external compression in 2 (15%). Thoracotomy and excision of the lymph node mass was necessary to treat the mediastinal compression and to ascertain the diagnosis of TB in 3 children (23%). All 13 children had complete resolution of tuberculous lymphadenitis following anti-tuberculous treatment. The diagnostic clues in this cohort of patients were cough and SOB with history of exposure to tuberculosis (P=0.0001) and bronchoscopy and lavage with positive staining for acid-fast bacilli (P=0.0001).
  
  
  CONCLUSIONS
  Tuberculosis was not suspected in 54% of children with MTL, and they posed diagnostic dilemma on admission. Bronchoscopy must be used as a diagnostic tool in children where tuberculosis cannot be excluded by radiology or specific skin tests. Thoracotomy and excision may be necessary to treat the obstructive symptoms.
authors.affiliation: Department of Paediatric Cardiac Surgery, Diana Princess of Wales Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.
authors.forename: R V
authors.initials: RV
authors.lastname: Venkateswaran
authors.forename: D J
authors.initials: DJ
authors.lastname: Barron
authors.forename: W J
authors.initials: WJ
authors.lastname: Brawn
authors.forename: J R
authors.initials: JR
authors.lastname: Clarke
authors.forename: M
authors.initials: M
authors.lastname: Desai
authors.forename: M
authors.initials: M
authors.lastname: Samuel
authors.forename: D H
authors.initials: DH
authors.lastname: Parikh
mesh_terms: D001999:Bronchoscopy; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008477:Mediastinal Diseases / Q000000981:diagnostic imaging* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014388:Tuberculosis, Lymph Node / Q000000981:diagnostic imaging* / Q000601:surgery