[Antithrombotic mechanisms in the acute period of severe brain injury].
Antithrombotic mechanisms were studied in 156 patients with severe brain injury (SBI) on days 1, 3, 5, 7, and 9 after injury. It was found that the acute period of SBI was marked by a reduction in the athrombogenic potential through both the consumption of physiological anticoagulants, antiaggregants, the components of the plasmin system and the elevated levels of fibrinolytic inhibitors. The inhibitory mechanism responsible for impaired fibrinolysis predominated when infectious complications of SBI developed.
Pavlenko
A A
AA
Epifantseva
N N
NN
Churliaev
Iu A
IuA
Sitnikov
P G
PG
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001774:Blood Chemical Analysis; D006259:Craniocerebral Trauma / Q000097:blood* / Q000150:complications / Q000378:metabolism; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000209:etiology; D013927:Thrombosis / Q000378:metabolism*