title: Lipoxygenase inhibiting constituents from Indigofera hetrantha.
abstract: A lignan and two acylphloroglucinols have been isolated from the ethyl acetate soluble fraction of the whole plant of Indigofera hetrantha. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. Compounds 1-3 displayed promising inhibitory potential against enzyme lipoxygenase in concentration-dependent manner.
authors.affiliation: International Centre for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Pakistan.
authors.lastname: Aziz-Ur-Rehman
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Naheed
authors.initials: N
authors.lastname: Riaz
authors.forename: Habib
authors.initials: H
authors.lastname: Ahmad
authors.forename: Sarfraz Ahmad
authors.initials: SA
authors.lastname: Nawaz
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D004187:Disaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029883:Indigofera / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009005:Monosaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009281:Naphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: C502842:1-((3-methylbutanoyl)phloroglucinyl)-beta-D-glucopyranoside; C502843:1-((pentanoyl)phloroglucinyl)-beta-D-glucopyranoside; D004187:Disaccharides; D016859:Lipoxygenase Inhibitors; D009005:Monosaccharides; D009281:Naphthalenes; C502840:lyoniresinol 4,4'-bis-O-beta-D-glucopyranoside; D010696:Phloroglucinol