Ex vivo measures of LDL oxidative susceptibility predict carotid artery disease.
OBJECTIVE
The purpose of the study was to assess whether ex vivo measures of low-density lipoprotein (LDL) oxidation improved prediction of carotid artery disease (CAAD) case-control status compared to standard lipid and smoking measures.


METHODS
One hundred and forty cases with a high degree of carotid artery stenosis aged 40-83 years and an equal number of controls without stenosis or other vascular disease were matched by censored age within 2 years. Matched logistic regression evaluated the significance of copper-induced oxidative measures with and without covariates. The relationship of LDL oxidation measures with statin use and current smoking was also evaluated.


RESULTS
Logistic regression demonstrated a significant effect of the three correlated measures of oxidative susceptibility (lag time, oxidation rate and maximal rate of oxidation) separately on disease prediction (all p<0.05). These oxidative measures remained significant predictors of case-control status when other cardiovascular disease predictors (age; LDL-C, HDL-C and ApoAI levels; current smoking, ever smoking and pack-years smoked) were jointly considered. This relationship was not attributable to the effects of statin use on LDL oxidation.


CONCLUSIONS
Ex vivo measures of oxidation improved the prediction of carotid artery disease status, suggesting that this is an important determinant of atherosclerotic risk in this older population.
Hendrickson
Audrey
A
Division of Medical Genetics, The University of Washington Department of Medicine, Seattle, WA 98195, USA.
McKinstry
Laura A
LA
Lewis
Julieann K
JK
Lum
Jeremy
J
Louie
Andy
A
Schellenberg
Gerard D
GD
Hatsukami
Thomas S
TS
Chait
Alan
A
Jarvik
Gail P
GP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002340:Carotid Artery Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism*; D016893:Carotid Stenosis / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000378:metabolism*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011237:Predictive Value of Tests; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology
D008078:Cholesterol, LDL