title: Regression models for the analysis of longitudinal Gaussian data from multiple sources.
abstract: We present a regression model for the joint analysis of longitudinal multiple source Gaussian data. Longitudinal multiple source data arise when repeated measurements are taken from two or more sources, and each source provides a measure of the same underlying variable and on the same scale. This type of data generally produces a relatively large number of observations per subject; thus estimation of an unstructured covariance matrix often may not be possible. We consider two methods by which parsimonious models for the covariance can be obtained for longitudinal multiple source data. The methods are illustrated with an example of multiple informant data arising from a longitudinal interventional trial in psychiatry.
authors.affiliation: Department of Mathematics, Colby College, 5838 Mayflower Hill, Waterville, ME 04901, USA. lobrien@colby.edu
authors.forename: Liam M
authors.initials: LM
authors.lastname: O'Brien
authors.forename: Garrett M
authors.initials: GM
authors.lastname: Fitzmaurice
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003627:Data Interpretation, Statistical; D005190:Family / Q000523:psychology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D019964:Mood Disorders / Q000523:psychology; D015999:Multivariate Analysis; D016011:Normal Distribution; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D012044:Regression Analysis
references.citation: Stat Med. 2001 Jan 15;20(1):21-31
references.pmid: 11135345
references.citation: Am J Epidemiol. 2002 Jan 1;155(1):88-94
references.pmid: 11772789
references.citation: Stat Med. 2002 Jan 15;21(1):143-64
references.pmid: 11782056
references.citation: Biometrics. 1982 Dec;38(4):963-74
references.pmid: 7168798
references.citation: Biometrics. 1986 Dec;42(4):805-20
references.pmid: 3814725
references.citation: Psychol Bull. 1987 Mar;101(2):213-32
references.pmid: 3562706
references.citation: J Clin Psychol. 1989 Nov;45(6):897-903
references.pmid: 2613899
references.citation: Biometrics. 1996 Jun;52(2):740-50
references.pmid: 8672710
references.citation: J Am Acad Child Adolesc Psychiatry. 1997 Feb;36(2):196-204
references.pmid: 9031572
references.citation: Stat Med. 1997 Feb 28;16(4):347-55
references.pmid: 9044525