title: Toxic effect of stem bark and leaf of Euphorbia hirta plant against freshwater vector snail Lymnaea acuminata.
abstract: The aqueous stem bark and leaf extracts of plant Euphorbia hirta (family-Euphorbiaceae) have potent molluscicidal activity. Sub-lethal doses (40% and 80% of LC50) of aqueous stem bark and leaf extracts of this plant also significantly (P<0.05) alter the levels of total protein, total free amino acid, nucleic acids (DNA and RNA) and the activity of enzyme protease and acid and alkaline phosphatase in various tissues of the vector snail Lymnaea acuminata in time and dose dependent manner. Euphorbia hirta (family-Euphorbiaceae) commonly known as Dudhi, is a common medicinal plant of India, which is used in variety of diseases i.e. cough, asthma, colic, dysentery, genito urinary diseases.
authors.affiliation: Natural Products Laboratory, Department of Zoology, D.D.U. Gorakhpur University, Gorakhpur 273 009, UP, India.
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Singh
authors.forename: Ram P
authors.initials: RP
authors.lastname: Yadav
authors.forename: Sudhanshu
authors.initials: S
authors.lastname: Tiwari
authors.forename: Ajay
authors.initials: A
authors.lastname: Singh
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D028481:Euphorbia; D005618:Fresh Water; D007194:India; D007928:Lethal Dose 50; D009696:Nucleic Acids / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D024301:Plant Bark / Q000633:toxicity*; D010936:Plant Extracts / Q000633:toxicity; D018515:Plant Leaves / Q000633:toxicity*; D010940:Plant Proteins / Q000378:metabolism; D012908:Snails / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
chemical_list: D000596:Amino Acids; D009696:Nucleic Acids; D010936:Plant Extracts; D010940:Plant Proteins; D010744:Phosphoric Monoester Hydrolases; D010447:Peptide Hydrolases