New aromatic compounds from the marine mangrove Bruguiera gymnorrhiza.
The phytochemical investigation of the stem of Bruguiera gymnorrhiza yielded five new aromatic compounds (1-5), of which the bruguierols A - C (1-3) represent a new structural skeleton in natural product chemistry. All structures have been determined by NMR spectroscopic studies. Among them, 3 showed moderate activity against Gram-positive and Gram-negative bacteria including mycobacteria and resistant strains (MICs 12.5 microg/mL).
Han
Li
L
Hans-Knöll Institute for Natural Products Research, Jena, Germany.
Huang
Xueshi
X
Sattler
Isabel
I
Moellmann
Ute
U
Fu
Hongzheng
H
Lin
Wenhan
W
Grabley
Susanne
S
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006575:Heterocyclic Compounds, 3-Ring / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D043982:Rhizophoraceae
D000900:Anti-Bacterial Agents; D006575:Heterocyclic Compounds, 3-Ring; D010936:Plant Extracts; C538743:bruguierol A