title: A der(19)t(12;19)(q12;p13.3) in a case of pediatric acute leukemia with unusual immunophenotype.
abstract: We describe a case of acute leukemia in a child with an unusual immunophenotype and a novel cytogenetic abnormality. The leukemia blasts expressed myeloid, natural killer and B-lineage associated antigens. Cytogenetics showed the presence of a novel unbalanced chromosomal translocation, der(19)t(12;19)(q12;p13.3). The patient achieved and maintained remission with myeloid-directed chemotherapy. The differential diagnosis of the immunophenotype and the potential fusion genes are discussed.
authors.affiliation: Division of Haematology/Oncology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
authors.forename: Elaine
authors.initials: E
authors.lastname: Leung
authors.forename: Ikuko
authors.initials: I
authors.lastname: Teshima
authors.forename: Charles
authors.initials: C
authors.lastname: Ye
authors.forename: Ron
authors.initials: R
authors.lastname: Grant
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdelhaleem
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002881:Chromosomes, Human, Pair 12; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D032681:Spectral Karyotyping; D014178:Translocation, Genetic