title: The mechanical or electrical induction of medullary angiogenesis: will it improve sternal wound healing?
abstract: We induced angiogenesis in the tibial medulla and cortex of rabbits by electrical and mechanical stimulation, with the aim of future application to ischemic disease. Sixteen New Zealand rabbits were divided into 4 groups: in Group 1, a K wire was inserted into the medullary channel; in Group 2 a hole was drilled into the tibia; in Group 3, electrical stimulation was applied to the medullary channel; and in Group 4 (the control group), nothing was done. The interventions were applied during a 21-day period, after which all animals were evaluated scintigraphically and histopathologically. All 3 interventional groups were significantly superior to the control group in regard to medullary and cortical vascularity: the P values were 0.021 in all comparisons to control. However, the most fibrotic changes in the medulla occurred in the group that had been treated with electricity (P = 0.008). Slight fibrotic changes occurred in the hole group (P = 0.040), and none occurred in the K-wire group. In sum, all 3 interventions are capable of inducing medullary angiogenesis, but electricity is inferior in regard to fibrotic change. We believe that this present study can establish a baseline for further work that explores clinical applications to problematic ischemic conditions, including delayed sternal wound healing after cardiac surgery.
authors.affiliation: Department of Cardiovascular Surgery, Inonu University Medical Faculty, Turgut Ozal Medical Center, 44069 Malatya, Turkey. ilkeralat@hotmail.com
authors.forename: Ilker
authors.initials: I
authors.lastname: Alat
authors.forename: Muharrem
authors.initials: M
authors.lastname: Inan
authors.forename: Iclal
authors.initials: I
authors.lastname: Gurses
authors.forename: Ersoy
authors.initials: E
authors.lastname: Kekilli
authors.forename: Burak
authors.initials: B
authors.lastname: Germen
authors.forename: Ahmet
authors.initials: A
authors.lastname: Harma
authors.forename: Ahmet
authors.initials: A
authors.lastname: Eskin
authors.forename: Omer Murat
authors.initials: OM
authors.lastname: Aydin
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000098:blood supply* / Q000503:physiopathology / Q000601:surgery; D001864:Bone Wires; D004558:Electric Stimulation; D023421:Models, Animal; D018919:Neovascularization, Physiologic; D010027:Osteotomy; D011817:Rabbits; D013249:Sternum / Q000601:surgery; D013977:Tibia / Q000098:blood supply* / Q000503:physiopathology / Q000601:surgery; D014945:Wound Healing
references.citation: Med Biol Eng Comput. 1993 May;31(3):213-20
references.pmid: 8412373
references.citation: J Bone Joint Surg Br. 1990 May;72(3):347-55
references.pmid: 2187877
references.citation: Circulation. 1999 May 25;99(20):2614-6
references.pmid: 10338451
references.citation: Circulation. 1999 May 25;99(20):2682-7
references.pmid: 10338463
references.citation: Ann Thorac Surg. 1999 Nov;68(5):1891-2
references.pmid: 10585096
references.citation: Ann Thorac Surg. 1999 Dec;68(6):2388-9
references.pmid: 10617055
references.citation: Anat Rec. 2000 Jun 15;261(3):126-35
references.pmid: 10867630
references.citation: Ann Thorac Surg. 2000 Sep;70(3):824-8
references.pmid: 11016317
references.citation: Ann Intern Med. 2002 Jan 1;136(1):54-71
references.pmid: 11777364
references.citation: J Thorac Cardiovasc Surg. 2002 Mar;123(3):508-11
references.pmid: 11882823
references.citation: Ann Thorac Surg. 2002 Apr;73(4):1210-5
references.pmid: 11996265
references.citation: Ann Thorac Surg. 2002 Sep;74(3):943-5
references.pmid: 12238881
references.citation: Ann Thorac Surg. 2004 Feb;77(2):672-5
references.pmid: 14759457
references.citation: J Invest Dermatol. 1983 Aug;81(2):144-8
references.pmid: 6308102
references.citation: Orthop Clin North Am. 1984 Jan;15(1):33-45
references.pmid: 6607440
references.citation: Exp Physiol. 1996 Nov;81(6):1043-6
references.pmid: 8960710