title: Interindividual reproducibility of glutamate quantification using 1.5-T proton magnetic resonance spectroscopy.
abstract: The goal of this study was to measure the interindividual reproducibility of glutamate quantification in 1.5-T (1)H MRS of human brains. To determine the effective echo time (TE) for glutamate quantification, spectra from a phantom and 12 participants were obtained with TE = 30, 35, 40, and 144 ms (repetition time (TR) = 2000 ms and volume of interest = 4 cm(3)). The average Cramer-Rao lower bounds for glutamate quantification using LCModel was lowest in two experiments when TE = 40 ms.Twenty-one subjects participated in experiments that measured interindividual reproducibility of glutamate quantification. Spectra were acquired with TR = 6000 ms and TE = 40 ms. Results showed that the coefficients of variance were 11.0 and 13.1% in the anterior cingulate cortex and insula, respectively. This suggests that glutamate can be reproducibly measured from 1.5-T (1)H MRS with long TR, effective TE, and the LCModel.
authors.affiliation: Department of Biomedical Engineering, Hanyang University, 17 Heangdang-dong, Sungdong-ku, Seoul 133-791, Korea.
authors.forename: Dong-Pyo
authors.initials: DP
authors.lastname: Jang
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Eun
authors.initials: E
authors.lastname: Lee
authors.forename: Sangjin
authors.initials: S
authors.lastname: Park
authors.forename: Jae-Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Kee
authors.initials: K
authors.lastname: Namkoong
authors.forename: Kang-Jun
authors.initials: KJ
authors.lastname: Yoon
authors.forename: In-Young
authors.initials: IY
authors.lastname: Kim
authors.forename: Sun I
authors.initials: SI
authors.lastname: Kim
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D015203:Reproducibility of Results
chemical_list: D018698:Glutamic Acid