title: [Biological approach for treatment of degenerative disc diseases].
abstract: Intervertebral disc degeneration and associated spinal disorders including low back pain are a leading source of morbidity and a major cause of work disability as well as increased health care costs. Recent advance of molecular biology enable us to utilize these new techniques for understanding disc cell function and mechanisms of disc degeneration. Furthermore, these new technology may open novel therapeutic strategy such as application of growth factors, stem cell therapy, and gene therapy to regenerate degenerated intervertebral discs.
authors.affiliation: Department of Orthopedic Surgery, Kobe University Graduate School of Medicine.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Nishida
authors.forename: Minoru
authors.initials: M
authors.lastname: Doita
authors.forename: Toru
authors.initials: T
authors.lastname: Takada
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Shimomura
authors.forename: Koichiro
authors.initials: K
authors.lastname: Maeno
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Kakutani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyamoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kurosaka
mesh_terms: D000818:Animals; D017690:Cell Transplantation; D016207:Cytokines / Q000627:therapeutic use; D015316:Genetic Therapy; D006801:Humans; D017116:Low Back Pain / Q000628:therapy*; D013122:Spinal Diseases / Q000628:therapy*
chemical_list: D016207:Cytokines