Stability indicating reversed-phase ion-pairing liquid chromatographic determination of vertilmicin sulfate as bulk drug and in injections.
A simple reversed-phase high performance liquid chromatographic method was developed for the analysis of vertilmicin sulfate, a novel aminoglycoside (AG). UV detection was used to determine vertilmicin sulfate and its related compounds in drug substance and products without sample derivatization. The method was used to determine the content of vertilmicin and its related compounds and test the stability of vertilmicin sulfate as drug substance and in injections, which was required for registration of new drug.
Liu
Zhen
Z
Department of Pharmaceutical Analysis, School of Pharmacy, Medical Center of Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, P.R. China. liuzhen1979@hotmail.com
Duan
Gengli
G
D000617:Aminoglycosides / Q000032:analysis* / Q000737:chemistry*; D002852:Chromatography, Ion Exchange / Q000379:methods; D002853:Chromatography, Liquid / Q000379:methods; D004355:Drug Stability; D017022:Flow Injection Analysis / Q000379:methods
D000617:Aminoglycosides; C487733:vertilmicin