Protective characteristics of platelets in tuberculosis.
We demonstrated specific changes in platelet structure in different types of tuberculous process, in particular, shift in the proportion between alpha-granules, dense granules, different disorders in the mitochondrial and lysosomal apparatus, etc. The role of platelets in immune process is studied. Redistribution of alpha-granules in platelets finds a new interpretation in light of psycho- and neurotropic effects of their contents. Adhesion and aggregation processes and granule release from platelets are regulated by the content of serotonin and cyclic nucleotides in these cells.
Khechinashvili
G N
GN
Department of Tuberculosis and Lung Diseases, National Center of Tuberculosis and Lung Diseases.
Khvitiya
N G
NG
D000244:Adenosine Diphosphate / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood; D001792:Blood Platelets / Q000473:pathology / Q000502:physiology*; D001800:Blood Specimen Collection; D002118:Calcium / Q000097:blood; D002395:Catecholamines / Q000097:blood; D006801:Humans; D012016:Reference Values; D012701:Serotonin / Q000097:blood; D014397:Tuberculosis, Pulmonary / Q000097:blood*
D002395:Catecholamines; D012701:Serotonin; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D002118:Calcium