Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. II. Structure elucidation.
A novel antifungal antibiotic, transvalencin A, is produced by Nocardia transvalensis IFM 10065 isolated from a patient with actinomycotic mycetoma in Japan. The antibiotic structure was elucidated using NMR, mass spectrometric investigations, and X-ray crystallographic analysis. Transvalencin A is a 1:1 complex of a zinc and an organic acid with a phenolic substituent. Transvalencin A is comprised of o-substituted p-chlorophenol, tetrasubstituted oxazoline, disubstituted thiazolyl-N-methylthiazolidine and monosubstituted N-methylthiazolidine.
Hoshino
Yasutaka
Y
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8673, Japan.
Mukai
Akira
A
Yazawa
Katsukiyo
K
Uno
Jun
J
Ando
Akikazu
A
Mikami
Yuzuru
Y
Fukai
Toshio
T
Ishikawa
Jun
J
Yamaguchi
Kentaro
K
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D015394:Molecular Structure; D009615:Nocardia / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D013844:Thiazoles; C498222:transvalencin A; D015032:Zinc