Obg/CtgA, a signaling protein that controls replication, translation, and morphological development?
The recent finding that the ObgE GTPase acts as a replication checkpoint protein in Escherichia coli has important implications. It reveals the existence of a new pathway of replication control by the nucleotide pool and suggests unsuspected links between replication, proteins synthesis, and cellular differentiation.
Michel
Bénédicte
B
Génétique Microbienne, Institut National de la Recherche Agronomique, 78350 Jouy en Josas, France.
D002876:Chromosomes, Bacterial / Q000235:genetics*; D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D014176:Protein Biosynthesis; D015398:Signal Transduction
D029968:Escherichia coli Proteins; C491572:ObgE protein, E coli; D020559:Monomeric GTP-Binding Proteins