Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.
Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.
Cooper
Sian M
SM
School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
Cox
Russell J
RJ
Crosby
John
J
Crump
Matthew P
MP
Hothersall
Joanne
J
Laosripaiboon
Wanpen
W
Simpson
Thomas J
TJ
Thomas
Christopher M
CM
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D015394:Molecular Structure; D005810:Multigene Family / Q000235:genetics*; D016712:Mupirocin / Q000096:biosynthesis*; D016297:Mutagenesis, Site-Directed; D011551:Pseudomonas fluorescens / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D016712:Mupirocin