Antidiuretic hormone-V2-receptor-aquaporin-2 system in rat kidneys during acute inflammation.
Expression of antidiuretic hormone V(2)-receptor, water channel protein aquaporin-2, and cytokines interleukin-1b and interleukin-6 was studied in the kidneys of rats with acute inflammation produced by intraperitoneal injection of lipopolysaccharide in a dose of 250 microg/100 g. Reduced expression of aquaporin-2 and V(2)-receptor led to impairment of concentration capacity in the kidneys and decrease in urine osmolarity.
Misharin
A V
AV
Research Center of Endocrinology, Russian Academy of Medical Sciences, Moscow, Russia. aml@mail.ru
Resnenko
A B
AB
Fidelina
O V
OV
Grinevich
V V
VV
Akmaev
I G
IG
D000208:Acute Disease; D000818:Animals; D051399:Aquaporin 2; D020346:Aquaporins / Q000502:physiology*; D004195:Disease Models, Animal; D004926:Escherichia coli; D007249:Inflammation / Q000503:physiopathology*; D007375:Interleukin-1 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D007668:Kidney / Q000503:physiopathology*; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017483:Receptors, Vasopressin / Q000502:physiology*; D012016:Reference Values; D012964:Sodium / Q000097:blood
C496025:Aqp2 protein, rat; D051399:Aquaporin 2; D020346:Aquaporins; D007375:Interleukin-1; D015850:Interleukin-6; D008070:Lipopolysaccharides; D017483:Receptors, Vasopressin; D012964:Sodium