Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis.
We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.
Venketaraman
Vishwanath
V
Department of Medicine, UMDNJ-New Jersey Medical School, 225 Warren St., Newark, NJ 07103, USA. venketvi@umdnj.edu
Dayaram
Yaswant K
YK
Talaue
Meliza T
MT
Connell
Nancy D
ND
D000818:Animals; D002460:Cell Line; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology*; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development*; D026422:S-Nitrosoglutathione / Q000494:pharmacology*
D008070:Lipopolysaccharides; D026422:S-Nitrosoglutathione; D007371:Interferon-gamma; D005978:Glutathione
Tuber Lung Dis. 1999;79(4):191-8
10692986
Tuber Lung Dis. 1997;78(5-6):237-46
10209678
Am J Respir Cell Mol Biol. 2001 Nov;25(5):606-12
11713103
Infect Immun. 2003 Apr;71(4):1864-71
12654802
Appl Microbiol. 1974 Jan;27(1):202-5
4589130
Med Hypotheses. 1987 Jul;23(3):253-7
3614016
J Exp Med. 1992 Apr 1;175(4):1111-22
1552282
Science. 1992 Aug 21;257(5073):1055-64
1509256
J Exp Med. 1993 Dec 1;178(6):2249-54
7504064
Immunity. 1995 Jun;2(6):561-72
7540941
Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6399-403
7604003
Annu Rev Immunol. 1997;15:323-50
9143691
J Immunol. 1998 Feb 15;160(4):1796-803
9469439
Nitric Oxide. 1998;2(3):174-86
9731635
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8841-8
10922044