Parameters of cell energy metabolism during stress in laboratory animals and energotropic effect of alpha1-adrenoblocker doxazosin.
Cytochemical activity of succinate dehydrogenase and lactate dehydrogenase in blood lymphocytes, activity of hydroperoxides, MDA, and blood plasma antioxidants were studied in experimental animals during immobilization stress after preliminary injection of doxazosin. Preliminary adrenergic receptor blockade prevented changes in cell metabolism characteristic of immobilization stress. The role of adrenergic regulation in the realization of energotropic effects during immobilization stress was examined.
Vishnevskii
E L
EL
Department of Urology, Moscow State Medical Dental University, Moscow, Russia.
Vishnevskii
A E
AE
Shabel'nikova
E I
EI
Safronova
O N
ON
Dreval
A A
AA
Topchieva
G V
GV
Sukhorukov
V S
VS
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D017292:Doxazosin / Q000008:administration & dosage / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D006861:Hydrogen Peroxide / Q000378:metabolism; D007103:Immobilization; D007274:Injections, Intraperitoneal; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D000317:Adrenergic alpha-Antagonists; D000975:Antioxidants; D008315:Malondialdehyde; D006861:Hydrogen Peroxide; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D017292:Doxazosin