title: Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus.
abstract: Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-beta-d-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.
authors.affiliation: Institute of Medical Virology, Johann Wolfgang Goethe University Frankfurt, Paul-Ehrlich-Strasse 40, 60596 Frankfurt, Germany.
authors.forename: Gerold
authors.initials: G
authors.lastname: Hoever
authors.forename: Lidia
authors.initials: L
authors.lastname: Baltina
authors.forename: Martin
authors.initials: M
authors.lastname: Michaelis
authors.forename: Rimma
authors.initials: R
authors.lastname: Kondratenko
authors.forename: Lia
authors.initials: L
authors.lastname: Baltina
authors.forename: Genrich A
authors.initials: GA
authors.lastname: Tolstikov
authors.forename: Hans W
authors.initials: HW
authors.lastname: Doerr
authors.forename: Jindrich
authors.initials: J
authors.lastname: Cinatl
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002522:Chlorocebus aethiops; D019695:Glycyrrhizic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects* / Q000302:isolation & purification; D013329:Structure-Activity Relationship; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D019695:Glycyrrhizic Acid