A familial occurrence of lip anomaly.
Lip pits are among the rarest congenital deformities recorded. Initially reported in 1845, its familial occurrence has been reported just once. These developmental anomalies occur either as an isolated defect or in association with other developmental deformities, including cleft lip, cleft palate, or both. They may be located at the commissures of the lips or at the midline of the lower lip. Lip pits are often inherited as an autosomal dominant trait with variable penetrance. Our report of a family in which all of the 3 children (2 girls and 1 boy) and their father were involved is in concert with the latter statement.
Zarandy
Masoud Motasaddi
MM
Department of Otolaryngology, Faculty of Medicine, Tehran University of Medical Sciences, Amir Alam Cancer, Iran. motesadi@sina.tums.ac.ir
Givehchi
Gilda
G
Mohammadi
Mahnaz
M
D000293:Adolescent; D002648:Child; D005260:Female; D005402:Fistula / Q000235:genetics*; D006801:Humans; D008046:Lip / Q000002:abnormalities*; D008047:Lip Diseases / Q000235:genetics*; D008297:Male