Hibernating myocardium in heart failure.
Ischemic left ventricular systolic dysfunction may result from myocardial necrosis or from hypocontractile areas of viable myocardium. In some cases, recovery of contractility may occur on revascularization--this reversibly dysfunctional tissue is commonly referred to as hibernating myocardium. Observational data suggest that revascularization of patients with ischemic left ventricular systolic dysfunction and known viable myocardium provides a survival benefit over medical therapy. Identification of viable, dysfunctional myocardium may be especially worthwhile in deciding which patients with ischemic left ventricular systolic dysfunction will benefit from revascularization procedures. Randomized, prospective trials evaluating this are currently ongoing. This review will provide an overview of the complex pathophysiology of viable, dysfunctional myocardium, and will discuss outcomes after revascularization. Of the techniques used to determine the presence of hibernating myocardium, functional methods such as stress echocardiography and cardiac magnetic resonance appear more specific, but less sensitive, than the nuclear modalities, which assess perfusion and metabolic activity. Currently, the availability of all methods is variable.
Bhatia
Gurbir
G
Sandwell Hospital, Department of Cardiology, Sandwell and West Birmingham NHS Trust, West Bromwich, UK.
Sosin
Michael
M
Leahy
John F
JF
Connolly
Derek L
DL
Davis
Russel C
RC
Lip
Gregory Y H
GY
D006333:Heart Failure / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D009204:Myocardial Revascularization; D017682:Myocardial Stunning / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D009206:Myocardium / Q000473:pathology; D014055:Tomography, Emission-Computed