[Study on genetic polymorphism of NQO1 and susceptibility to benzene poisoning].
OBJECTIVE
To explore the relationship between genetic polymorphism of NQO1 and susceptibility to benzene poisoning (BP).


METHODS
The genetic polymorphism of NQO1 for 100 patients with benzene poisoning and 90 workers exposed to benzene who were engaged in the same working time and job title as patients with benzene poisoning were detected by PCR-RFLP.


RESULTS
There was a 2.82-fold (95% CI: 1.42-5.58 ) increased risk of BP in the subjects with NQO1 C609T mutation genotype (T/T) compared with those carrying heterozygous (C/T) and wild type (C/C), and there was a 2.94-fold (95% CI: 1.25-6.90) increased risk of BP in the subjects with NQO1 C609T mutation genotype (T/T) compared with those carrying wild type (C/C) . There was a trend that the risk of BP in subjects with NQO1 C609T mutation genotype (T/T) was higher than those carrying heterozygous (C/T) and even higher than those carrying wild type (C/C) (chi2(trend) = 6.01, P = 0.014).


CONCLUSIONS
The subjects with NQO1 C609T mutation genotype (T/T) were more susceptive to benzene and NQO1 is as a biomarker to assessment the risk of benzene poisoning for individual.
Chen
Yan
Y
Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Ji
Zhiying
Z
Xu
Jianning
J
Wu
Chunling
C
Li
Guilan
G
D001554:Benzene / Q000506:poisoning*; D005838:Genotype; D006801:Humans; D009154:Mutation; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D009784:Occupational Diseases / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human; D001554:Benzene