[Expression of CD30 in nasal mucosa of patients with allergic rhinitis].
OBJECTIVE
To study the role of CD30 in the pathogenesis of allergic rhinitis.


METHODS
The specimens of thirty-one patients with allergic rhinitis and twenty-six control subjects were studied by immunohistochemical method to detect CD30 cell. A mean numbers of positive cells per high field (10 x 40) were counted. All data were analyzed with t-test.


RESULTS
The number of CD30+ cells in the nasal mucosa of patients with allergic rhinitis was significantly more than that in the controls (P < 0.05).


CONCLUSIONS
This study suggests a T-helper 2-dominated mucosal reaction in the allergic rhinitis compared to the nonallergic groups,and the expression level of CD30 can reflect the T-helper 2-dominated mucosal reaction.
Xu
Zhihong
Z
Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yang
Chengzhang
C
Tang
Wei
W
D000328:Adult; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology* / Q000473:pathology; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology
D017730:Ki-1 Antigen