title: [The best of clinical pharmacology in 2004].
abstract: The year 2004 was not marked by major pharmacological advances, but by confirmation of previous "evidence". Several innovative drugs for stable angina (ranolazine, ivabradine), some interesting results in acute coronary syndrome (PROVE IT study), some classic concepts (cannabinoid receptors and their antagonists such as rimonabant) applied to novel indications (treatment of obesity), hopes for the "sartans" revived in the light of new evidence (VALUE study), advances in the management of diabetes and hypertension (ASCOT and CARDS studies), nebivolol which is not just a betablocker but also produces the NO radical (is this why it decreased the mortality of heart failure in the elderly in the SENIOR study?). In contrast, although Chronadalate did not live up to expectations for coronary insufficiency, the year was marked above all by the much heralded withdrawal of Vioxx for increasing cardiovascular risk. The old adage: primum non nocere springs to mind.
authors.affiliation: CHU Marseille, hôpital Sainte-Marguerite, Marseille.
authors.forename: P
authors.initials: P
authors.lastname: Ambrosi
authors.forename: M
authors.initials: M
authors.lastname: Andrejak
authors.forename: M D
authors.initials: MD
authors.lastname: Drici
authors.forename: D
authors.initials: D
authors.lastname: Herpin
authors.forename: I
authors.initials: I
authors.lastname: Pithois-Merli
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D048909:Diabetes Complications / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D009765:Obesity / Q000150:complications / Q000188:drug therapy; D013777:Tetrazoles / Q000627:therapeutic use; D014633:Valine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000068756:Valsartan
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D013777:Tetrazoles; D000068756:Valsartan; D014633:Valine