title: Association of a genetic polymorphism of the E-cadherin gene with prostate cancer in a Japanese population.
abstract: The E-cadherin gene has been identified as having a physiological role in cellular attachment, and is hypothesized to participate in carcinogenesis. A polymorphism (an A to C substitution) in the 5'-untranslated region has a direct effect on E-cadherin gene transcriptional regulation. We explored the association between E-cadherin gene polymorphism and the risk of prostate cancer in a Japanese population. The subjects consisted of 236 patients with prostate cancer, 209 benign prostatic hyperplasia (BPH) patients and 139 male controls. A marginally significant difference was found between prostate cancer patients and male controls (P = 0.053). No significant difference was observed between prostate cancer and BPH patients. When patients with prostate cancer were divided into two groups, stage A+B and stage C+D, a significant difference was observed between progressive cancer patients (stage C+D) and male controls (odds ratio = 1.93, P = 0.016). It is possible that the presence of one A allele resulted in an increased risk of cancer progression.
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Shogoin Kawahara-cho 54, Sakyo-ku, Kyoto City, Kyoto 606-8507, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kamoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Isogawa
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Sachiko
authors.initials: S
authors.lastname: Minamiguchi
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kakehi
authors.forename: Kenji
authors.initials: K
authors.lastname: Mitsumori
authors.forename: Shingo
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Tomonori
authors.initials: T
authors.lastname: Habuchi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kato
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data; D015820:Cadherins / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011470:Prostatic Hyperplasia / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors
chemical_list: D015820:Cadherins