title: 3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis.
abstract: Structure-activity relationship studies, focused on identification of the active pharmacophore fragments in a single high-throughput screening calcilytic hit, resulted in the discovery of potent calcium receptor antagonists, substituted 3H-quinazolin-4-ones.
authors.affiliation: Drug Discovery, NPS Pharmaceuticals, Inc., 383 Colorow Drive, Salt Lake City, UT 84108, USA. ishcherbakova@npsp.com
authors.forename: Irina
authors.initials: I
authors.lastname: Shcherbakova
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Balandrin
authors.forename: John
authors.initials: J
authors.lastname: Fox
authors.forename: Anjan
authors.initials: A
authors.lastname: Ghatak
authors.forename: William L
authors.initials: WL
authors.lastname: Heaton
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Conklin
mesh_terms: D000818:Animals; D008297:Male; D008956:Models, Chemical; D015394:Molecular Structure; D010024:Osteoporosis / Q000188:drug therapy; D010281:Parathyroid Hormone / Q000097:blood; D011799:Quinazolines / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D044169:Receptors, Calcium-Sensing / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: C501908:NPS53574; D010281:Parathyroid Hormone; D011799:Quinazolines; D044169:Receptors, Calcium-Sensing