title: Photoaffinity labeling of P-glycoprotein.
abstract: The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and propafenones. These studies allowed identification of protein regions, which are involved in ligand interaction.
authors.affiliation: Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Peer
authors.forename: Edina
authors.initials: E
authors.lastname: Csaszar
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Vorlaufer
authors.forename: Stephan
authors.initials: S
authors.lastname: Kopp
authors.forename: Peter
authors.initials: P
authors.lastname: Chiba
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D006801:Humans; D008024:Ligands; D019920:Photoaffinity Labels / Q000737:chemistry*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008024:Ligands; D019920:Photoaffinity Labels