title: Post-infectious irritable bowel syndrome in patients with Shigella infection.
abstract: OBJECTIVE
  Bacterial gastroenteritis has been known as a risk factor of irritable bowel syndrome (IBS). Several risk factors of post-infectious IBS (PI-IBS) have been documented. The aims of this study were to verify the role of bacterial gastroenteritis in the development of IBS and the risk factors for the development of PI-IBS. The clinical course of PI-IBS was also investigated.
  
  
  METHODS
  We recruited 143 patients with shigellosis during its outbreak and 113 controls. Both groups were followed up for 12 months. Bowel symptoms were evaluated by use of questionnaires at 3, 6 and 12 months after the initial recruitment.
  
  
  RESULTS
  Complete data were obtained from 101 patients (70.6%) and 102 healthy controls (90.3%). At 12 months, 15 patients and six controls had IBS (adjusted OR; 2.9, 95% CI; 1.1-7.9). Of the 15 patients, five had IBS symptoms consistently for 12 months, three did not have IBS symptoms initially and seven had fluctuating bowel symptoms. The duration of diarrhea was an independent risk factor of PI-IBS.
  
  
  CONCLUSIONS
  Bacterial gastroenteritis is a risk factor of IBS and the duration of diarrhea as the index of severity of initial illness is an independent risk factor of PI-IBS. The clinical course of PI-IBS is variable over the 1 year of follow-up.
authors.affiliation: Yonsei Institute of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sangwon
authors.initials: S
authors.lastname: Ji
authors.forename: Hyojin
authors.initials: H
authors.lastname: Park
authors.forename: Dokyong
authors.initials: D
authors.lastname: Lee
authors.forename: Young Koo
authors.initials: YK
authors.lastname: Song
authors.forename: Jae Phil
authors.initials: JP
authors.lastname: Choi
authors.forename: Sang-In
authors.initials: SI
authors.lastname: Lee
mesh_terms: D000328:Adult; D003428:Cross Infection / Q000453:epidemiology; D004196:Disease Outbreaks; D004405:Dysentery, Bacillary / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D043183:Irritable Bowel Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012764:Shigella sonnei / Q000302:isolation & purification*; D011795:Surveys and Questionnaires