title: Permanent pacing is a risk factor for the development of heart failure.
abstract: No previous study has examined the importance of right ventricular pacing as a risk factor for the development of heart failure (HF) in subjects without a history of HF. A cohort study of patients who underwent initial pacemaker implantation (n = 11,426) was conducted to test the hypothesis that patients with ventricular dyssynchrony created by permanent pacing would develop HF, as shown by new HF hospitalizations or HF-related deaths, at a higher rate than matched controls.
authors.affiliation: Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA. freuders@umdnj.edu
authors.forename: Ronald S
authors.initials: RS
authors.lastname: Freudenberger
authors.forename: Alan C
authors.initials: AC
authors.lastname: Wilson
authors.forename: Janet
authors.initials: J
authors.lastname: Lawrence-Nelson
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Hare
authors.forename: John B
authors.initials: JB
authors.lastname: Kostis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002304:Cardiac Pacing, Artificial / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000209:etiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors; D016019:Survival Analysis