title: Cell-permeable GPNA with appropriate backbone stereochemistry and spacing binds sequence-specifically to RNA.
abstract: Guanidine-based peptide nucleic acid (GPNA) with a d-backbone configuration and alternate spacing binds sequence-specifically to RNA and is readily taken up by both human somatic and embryonic stem (ES) cells.
authors.affiliation: Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA.
authors.forename: Anca
authors.initials: A
authors.lastname: Dragulescu-Andrasi
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.forename: Gaofei
authors.initials: G
authors.lastname: He
authors.forename: Danith H
authors.initials: DH
authors.lastname: Ly
mesh_terms: D001483:Base Sequence; D002463:Cell Membrane Permeability; D004247:DNA / Q000737:chemistry; D004151:Dipeptides / Q000737:chemistry* / Q000378:metabolism*; D020868:Gene Silencing; D006367:HeLa Cells; D006801:Humans; D009840:Oligomycins; D012313:RNA / Q000235:genetics* / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D004151:Dipeptides; D009840:Oligomycins; C007866:glutarylphenylalanine-4-nitroanilide; D012313:RNA; D004247:DNA