title: Fatigue is not a specific symptom in patients with primary biliary cirrhosis.
abstract: BACKGROUND
  Fatigue has been reported to be common in patients with primary biliary cirrhosis (PBC). Limited data exist on comparison with fatigue in the general population and comparison with patients with other chronic gastrointestinal disorders are lacking.
  
  
  METHODS
  We enrolled 96 patients with PBC (87 females); mean age 63 (range 34-65) who completed the Fatigue Impact Scale (FIS). In comparison we included matched controls from the general population, patients with organic (OGD) and functional GI disorders (FGD). Liver function test and the latest liver biopsy were analysed and correlated with fatigue scores.
  
  
  RESULTS
  The mean duration of PBC was 7.4 years, the mean bilirubin 13 micromol/l. Twelve per cent of patients had cirrhosis, 29% were in stage I on Ludwig's histology score and 30% and 29% were in stages II and III, respectively. The PBC patients had a median FIS total score of 29 in comparison with 38 in GP controls (P<0.05). Patients with OGD and FGD had more severe fatigue (FIS total score 67 and 59 (P<0.01 compared with PBC)). Fatigue in the PBC patients did not correlate with liver tests and histology stage.
  
  
  CONCLUSIONS
  PBC patients had less severe fatigue measured with the FIS than controls from the GP and patients with OGD and FGD. This study also confirms results of other studies showing no correlation with fatigue in PBC and liver disease parameters. These results argues strongly against fatigue as a specific symptom in PBC.
authors.affiliation: Department of Internal Medicine, Section of Gastroenterology and Hepatology, Sahlgrenska University Hospital, Gothenburg Sweden. einar.bjornsson@medic.gu.se
authors.forename: Einar
authors.initials: E
authors.lastname: Björnsson
authors.forename: Magnus
authors.initials: M
authors.lastname: Simren
authors.forename: Rolf
authors.initials: R
authors.lastname: Olsson
authors.forename: Roger W
authors.initials: RW
authors.lastname: Chapman
mesh_terms: D000328:Adult; D000368:Aged; D003863:Depression / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D005221:Fatigue / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D008297:Male; D005222:Mental Fatigue / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D008875:Middle Aged; D011581:Psychological Tests; D011788:Quality of Life