Icodextrin re-absorption varies with age in children on automated peritoneal dialysis.
Information on the use of Icodextrin in children remains scarce; however, it is believed that the characteristics are similar across all ages. We report the use of Icodextrin in a cohort of pediatric automated peritoneal dialysis (APD) patients younger than those previously reported (n=8, median age of 2.8, range 0.02-17.1 years). Net Icodextrin daytime dwell ultrafiltration was calculated in each patient for every day on therapy as ml/h/m2. Half of the patients showed re-absorption even when reducing Icodextrin dwells from a median of 10 to 6 h. All four patients who re-absorbed the Icodextrin (ranging from -23.7+/-7.5 to -2.5+/-6.0 ml/h/m2) were treated with cyclic nocturnal APD, and three of these four patients were high transporters on the peritoneal equilibration test (PET). Icodextrin fluid removal correlated significantly with age (Spearman rank r=0.8571, P=0.0107). The data suggest that Icodextrin behaves differently in young children.
Dart
Allison
A
Department of Pediatrics, Division of Nephrology, Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada.
Feber
Janusz
J
Wong
Hubert
H
Filler
Guido
G
D000042:Absorption; D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015314:Dialysis Solutions / Q000493:pharmacokinetics*; D005260:Female; D005936:Glucans / Q000493:pharmacokinetics*; D005947:Glucose / Q000493:pharmacokinetics*; D006801:Humans; D000077607:Icodextrin; D007223:Infant; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D010530:Peritoneal Dialysis / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome
D015314:Dialysis Solutions; D005936:Glucans; D000077607:Icodextrin; D005947:Glucose
Pediatr Nephrol. 2000 Nov;15(1-2):21-4
11095005
Adv Perit Dial. 2000;16:174-6
11045287
Adv Perit Dial. 1999;15:171-4
10682096
Perit Dial Int. 2000 Nov-Dec;20(6):603-6
11216547
Nephrol Dial Transplant. 1999 Jun;14 (6):1530-5
10383020
Drugs. 2003;63(19):2079-105
12962523
Perit Dial Int. 1997 Jan-Feb;17 (1):84-7
9068029
Nephrol Dial Transplant. 2003 Jul;18(7):1383-7
12808177
Am J Kidney Dis. 2002 Apr;39(4):862-71
11920355
Artif Organs. 1998 Jan;22(1):8-12
9456219
Nephrol Dial Transplant. 1997 Mar;12 (3):550-3
9075139
J Am Soc Nephrol. 2003 Sep;14 (9):2338-44
12937311
Perit Dial Int. 1994;14(3):236-9
7948234