title: Depression vulnerability, cigarette smoking, and the serotonin transporter gene.
abstract: People with current or past depression are more likely to have been smokers at some point in their lives. Smokers with depression histories are also less likely to quit. Attempts to understand this relationship are important insofar as they can help treatment efficacy for this group of smokers. Prior research indicates that different genetic variations affect the relationship between smoking and neuroticism. This study examined whether people with a short serotonin transporter genotype would likewise show a stronger relationship between depression vulnerability and smoking behavior than those with the long genotype. Although depression vulnerability was associated with smoking behaviors, genotype did not significantly affect this relationship. Discussion centered on possible reasons for varying results across conceptually similar studies.
authors.affiliation: Department of Psychology, Asbury Building, American University, Washington, DC 20016-8062, USA.
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Brody
authors.forename: Dean H
authors.initials: DH
authors.lastname: Hamer
authors.forename: David A F
authors.initials: DA
authors.lastname: Haaga
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect; D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000235:genetics* / Q000523:psychology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics*; D008875:Middle Aged; D009042:Motivation; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012044:Regression Analysis; D050486:Serotonin Plasma Membrane Transport Proteins; D012720:Severity of Illness Index; D012907:Smoking / Q000235:genetics* / Q000523:psychology; D016540:Smoking Cessation / Q000523:psychology; D014029:Tobacco Use Disorder / Q000235:genetics / Q000523:psychology
chemical_list: D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins