title: Synthesis of phosphorofluoridates and phosphorofluoridothioates via the phosphoramidite approach.
abstract: We present a very efficient synthetic procedure leading to the phosphorofluoridates RO-P(O)(OH)F 1 or phosphorofluoridothioates RO-P(S)(OH)F 2, which is based on the intermediary of fluorophosphoramidites (RO)P(F)N(i)Pr2 5 [R = 9-(hydroxyethyloxymethyl)guaninyl), 3'azido-3'deoxythymidinyl, thymidinyl, anhydrothymidinyl, cholesteryl, N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosinyl]. The activation of the amino group was performed with trimethylchlorosilane (TMCS).
authors.affiliation: Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90-363, Łódź, Sienkiewicza 112, Poland. wdabkow@bilbo.cbmm.lodz.pl
authors.forename: Wojciech
authors.initials: W
authors.lastname: Dabkowski
authors.forename: Izabela
authors.initials: I
authors.lastname: Tworowska
mesh_terms: D005459:Fluorides / Q000737:chemistry; D005461:Fluorine / Q000737:chemistry; D017611:Fluorine Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D013457:Sulfur Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D017611:Fluorine Compounds; D009943:Organophosphorus Compounds; D010710:Phosphates; D013457:Sulfur Compounds; C434331:phosphoramidite; C012980:fluorophosphate; D005461:Fluorine; D005459:Fluorides