Microwave-assisted sequential amide bond formation and intramolecular amidation: a rapid entry to functionalized oxindoles.
A general method has been developed for the synthesis of N-substituted oxindoles. The two-step process involves initial microwave-assisted amide bond formation between 2-halo-arylacetic acids and various alkylamines and anilines, followed by a palladium-catalyzed intramolecular amidation under aqueous conditions. In the case of alkylamines, the procedure can be carried out as a one-pot process without isolation of the intermediate amide. [structure: see text]
Poondra
Rajamohan R
RR
School of Chemistry, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JJ, Scotland, UK.
Turner
Nicholas J
NJ