Susceptibility of Streptococcus mutans and Actinobacillus actinomycetemcomitans to bactericidal activity of human beta-defensin 3 in biological fluids.
Bactericidal activity of human beta-defensin 3 (hBD-3) against Streptococcus mutans and Actinobacillus actinomycetemcomitans was inhibited in a dose-dependent manner by the presence of saliva and/or serum. Increasing the concentration of hBD-3 partially overcame this inhibition. A fast bactericidal effect was observed against both bacterial strains, suggesting a potential therapeutic use for hBD-3 in the local treatment of oral infections.
Maisetta
Giuseppantonio
G
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Via San Zeno 35-39, 56127 Pisa, Italy.
Batoni
Giovanna
G
Esin
Semih
S
Raco
Giorgio
G
Bottai
Daria
D
Favilli
Flavia
F
Florio
Walter
W
Campa
Mario
M
D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects*; D000658:Amoxicillin / Q000494:pharmacology; D002710:Chlorhexidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests; D012463:Saliva / Q000276:immunology*; D013295:Streptococcus mutans / Q000187:drug effects*; D023083:beta-Defensins / Q000494:pharmacology*
C422950:DEFB103A protein, human; D023083:beta-Defensins; D000658:Amoxicillin; D002710:Chlorhexidine
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