Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies.
An improved wound dressing with a long-term drug diffusion-efficacy has been developed by UV-radiation technique. It involves incorporation of ciprofloxacin (CIP), at the concentration of 0.5-2.0% (w/v), into a water mixture of 2-hydroxymethacrylate (HEMA) monomer, benzoin isobutyl ether (BIE) initiator and different content of ethylene glycol dimethacrylate (EGDMA) cross-linker. Increasing the concentration of EGDMA would reduce the releasing ratio of CIP from pHEMA. T1/2 is increased from 2.64 to 45.67 h when the EGDMA is added from 1 to 8%. In the ranges of 0< or = F < or = 0.6, the n value of 1%CIP-pHEMA membranes is increased from 0.48 to 0.81. It indicates that the mechanism of drug release falls between the Fickian and Case II diffusion model. The antibacterial activity of the drug impregnated into the membrane was evaluated by in vitro drug kinetic agar plate method. Higher concentration of EGDMA, up to 8% of the cross-linker, extends the drug release. Comparison with the drug-soaked membranes, the newly synthesized 1% CIP-pHEMA membrane (cross-linked with 4% EGDMA) sustains the release of the entrapped drug and maintains the antibacterial activity up to 12 days.
Tsou
Tai-Li
TL
Institute of Preventive Medicine, National Defense Medical Center, National Defense University, P.O. Box 90048-700, Sanshia, Taipei, Taiwan, Republic of China. doky@ispeed.com.tw
Tang
Shang-Tao
ST
Huang
Yu-Chuan
YC
Wu
Jing-Ran
JR
Young
Jenn-Jong
JJ
Wang
Hsian-Jenn
HJ
D000042:Absorption; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D047070:Bandages, Hydrocolloid; D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry* / Q000528:radiation effects; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry* / Q000528:radiation effects; D004058:Diffusion; D006801:Humans; D007700:Kinetics; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry / Q000528:radiation effects; D011102:Polyhydroxyethyl Methacrylate / Q000032:analysis / Q000737:chemistry* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014946:Wound Infection / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D008689:Methacrylates; D011102:Polyhydroxyethyl Methacrylate; D002939:Ciprofloxacin; C004919:ethylene dimethacrylate
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