title: Modulation of the ARF-p53 pathway by the small DNA tumor viruses.
abstract: The small DNA tumor viruses encode proteins that subvert many of the pivotal growth regulatory pathways within the cell to facilitate their own replication. The cell responds to viral infection/proteins by activating the p53 tumor suppressor pathway. Activation of p53 could impair a productive viral infection at many levels, including the inhibition of viral DNA replication and/or the premature death of infected cells. Therefore, DNA viruses encode proteins that inactivate the p53 tumor suppressor pathway. Understanding how DNA viral proteins activate/inactivate the p53 pathway has provided invaluable insights into tumorigenesis. Recent studies with polyoma virus have identified a viral protein (PyST) that inhibits ARF-mediated activation of p53, and revealed a novel role for PP2A in the regulation of the ARF-p53 tumor suppressor pathway.
authors.affiliation: UCSF Cancer Research Institute, San Francisco, California 94115, USA.
authors.forename: Clodagh C
authors.initials: CC
authors.lastname: O'Shea
authors.forename: Mike
authors.initials: M
authors.lastname: Fried
mesh_terms: D020823:ADP-Ribosylation Factor 1 / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000378:metabolism; D002453:Cell Cycle; D004247:DNA / Q000737:chemistry*; D004279:DNA, Viral / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D016147:Genes, Tumor Suppressor; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D009687:Nuclear Proteins; D009858:Oncogenic Viruses / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000952:Antigens, Polyomavirus Transforming; D004279:DNA, Viral; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53; D004247:DNA; D020823:ADP-Ribosylation Factor 1