Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholism.
The present study examined the association of the Tyrosine hydroxylase Val-81-Met polymorphism with alcohol dependence. One hundred and fifty-nine patients in a psychiatric unit with alcohol dependence were genotyped as well as 92 healthy volunteers. The Val allele was more frequent in patients with alcohol dependence (69.5%) than in controls (62.5%). This effect was largely due to the association with early-onset alcoholism (77.8%), whereas no difference was noted between late-onset patients and controls. Our results suggest a role for tyrosine hydroxylase in early-onset alcoholism.
Dahmen
Norbert
N
Department of Psychiatry, University of Mainz, Germany. ndahmen@psychiatrie.klinik.uni-mainz.de
Völp
Markus
M
Singer
Peter
P
Hiemke
Christoph
C
Szegedi
Armin
A
D000328:Adult; D017668:Age of Onset; D000437:Alcoholism / Q000201:enzymology / Q000235:genetics*; D001483:Base Sequence; D017931:DNA Primers; D005838:Genotype; D006801:Humans; D008715:Methionine; D020125:Mutation, Missense; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012016:Reference Values; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*; D014633:Valine
D017931:DNA Primers; D008715:Methionine; D014446:Tyrosine 3-Monooxygenase; D014633:Valine