Additional pyrrolomycins from cultures of Streptomyces fumanus.
Along with dioxapyrrolomycin (1), four new pyrrolomycin antibiotics, namely, pyrrolomycin G (3), pyrrolomycin H (4), pyrrolomycin I (5), and pyrrolomycin J (6), were produced in cultures of Streptomyces fumanus. Apart from dioxapyrrolomycin, pyrrolomycin G and pyrrolomycin H are the only other chiral members of the pyrrolomycin family of antibiotics, and their absolute stereochemistry was deduced to be 13S. Here, we report the isolation, structure elucidation, and antimicrobial activity of these new pyrrolomycins.
Charan
Romila D
RD
Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA.
Schlingmann
Gerhard
G
Bernan
Valerie S
VS
Feng
Xidong
X
Carter
Guy T
GT
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D011758:Pyrroles; C053531:pyrroxamycin; C034690:pyrrolomycin C