title: Polypharmacy treatment approaches to the psychiatric and somatic comorbidities found in patients with chronic pain.
abstract: This review outlines the following: psychiatric and somatic comorbidities associated with chronic pain and their relationship to polypharmacy treatment, indications for polypharmacy in chronic pain, criteria for rational polypharmacy, basic principles of polypharmacy for pain-associated comorbidity, and, based on the above, psychopharmacologic polypharmacy treatment approaches to these chronic pain-associated comorbidities.
authors.affiliation: Department of Psychiatry, University of Miami School of Medicine and Rosomoff Pain Center, Miami Beach, Florida, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Fishbain
mesh_terms: D002908:Chronic Disease; D015897:Comorbidity; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000453:epidemiology*; D019964:Mood Disorders / Q000188:drug therapy / Q000453:epidemiology; D010146:Pain / Q000188:drug therapy* / Q000453:epidemiology*; D019338:Polypharmacy