title: Efficacy of micafungin against deep-seated candidiasis in cyclophosphamide-induced immunosuppressed mice.
abstract: OBJECTIVE
  We investigated the effects of fluconazole and micafungin for the therapy of deep-seated candidiasis in a cyclophosphamide-induced immunosuppressed mouse model.
  
  
  METHODS
  We used the experimental model of intraperitoneal fungal abscess caused by Candida albicans, as described previously.
  
  
  CONCLUSIONS
  Micafungin efficacy was equal to that of fluconazole in one-tenth dosage even in peritonitis. We also assessed the short-term (24 h) and long-term (8 days) therapeutic effects after the end of therapy. Although the therapeutic effect of fluconazole was similar to that of micafungin at 24 h after the end of therapy, the effect of micafungin was superior to that of fluconazole at 8 days after the end of therapy.
authors.affiliation: Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Mochiyoshi
authors.initials: M
authors.lastname: Ninomiya
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Mikamo
authors.forename: Kaori
authors.initials: K
authors.lastname: Tanaka
authors.forename: Kunitomo
authors.initials: K
authors.lastname: Watanabe
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Tamaya
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy* / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D054714:Echinocandins; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000494:pharmacology; D055666:Lipopeptides; D008074:Lipoproteins / Q000627:therapeutic use*; D000077551:Micafungin; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D013047:Specific Pathogen-Free Organisms
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D007166:Immunosuppressive Agents; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D003520:Cyclophosphamide; D015725:Fluconazole; D000077551:Micafungin