title: Case-controlled clinical and histopathological study of conjunctivochalasis.
abstract: OBJECTIVE
  Conjunctivochalasis, a secondary cause of the watery eye, is frequently seen in the older age group as an elevation of the bulbar conjunctiva lying along the lateral or central lower lid margin. A prospective, interventional, case-controlled clinical and histopathological study was conducted. The relevant features of 18 patients (29 eyes) who had their conjunctivochalasis resected as part of the surgical management of their watery eye syndrome were examined. In the control group, tissue was obtained from an age matched series of 24 normal subjects undergoing routine cataract surgery.
  
  
  METHODS
  24 controls (24 specimens) and 18 patients (29 specimens) had conjunctival strip biopsies, taken from the usual lid margin level bulbar conjunctiva in line with the inferior limbus (controls), and the clinically apparent conjunctivochalasis (patients). These were submitted for histological study.
  
  
  RESULTS
  23 of 24 control sections demonstrated normal conjunctival variation. Four of 29 patient specimens demonstrated a chronic non-granulomatous conjunctivitis, while three eyes of the patient group (two patients) demonstrated features of elastosis. Of the four patients who had the inflammatory infiltrates, three had functional nasolacrimal duct obstructions (FNLDOs) and one had a primary acquired nasolacrimal duct obstruction (PANDO). Of the two patients who had elastosis, one had an FNLDO and the other had normal lacrimal drainage and was Jones 1 positive.
  
  
  CONCLUSIONS
  Six of 18 patients--that is, seven of 29 specimens of conjunctivochalasis demonstrated signs of elastosis or of chronic non-granulomatous inflammation. Clinically, patients had a spectrum of aetiologies of their watery eye syndrome.
authors.affiliation: The Ocular Plastics Unit, Depratment of Ophthalmology, The Prince of Wales Hospital, Randwick, Sydney, Australia. if@student.unsw.edu.au
authors.forename: I C
authors.initials: IC
authors.lastname: Francis
authors.forename: D G
authors.initials: DG
authors.lastname: Chan
authors.forename: P
authors.initials: P
authors.lastname: Kim
authors.forename: G
authors.initials: G
authors.lastname: Wilcsek
authors.forename: M
authors.initials: M
authors.lastname: Filipic
authors.forename: J
authors.initials: J
authors.lastname: Yong
authors.forename: M T
authors.initials: MT
authors.lastname: Coroneo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003228:Conjunctiva / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D003229:Conjunctival Diseases / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D015352:Dry Eye Syndromes / Q000473:pathology; D004548:Elasticity; D005143:Eyelids / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
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