title: [Effects of intranasal cortocosteroidson on the expression of Aquaporin-5 in human nasal polyps].
abstract: OBJECTIVE
  To observe the effects of intranasal Fluticasone propionate on the expression of Aquaporin-5 in nasal polyps and explore the role of AQP-5 in the formation of nasal polyps.
  
  
  METHODS
  Twenty cases of nasal polyps were selected. Fluticasone propionate were intranasally used in 10 cases of nasal polyps for 7-10 days before operation. The others, treated with nothing, were used as control. Twenty samples nasal polyps were obtained and studied with immunochemistric technique.
  
  
  RESULTS
  The expression of AQP-5 positive cells in the blood vessel endothelium was statistically significantly redueced in the Fluticasone propionate-using group compared with the control group (P < 0.05). The difference of AQP-5 positive cells in mucosal epithelial and glandular epithelium was not statistically significant between the Fluticasone propionate-using group and the control group.
  
  
  CONCLUSIONS
  (1) AQP-5 might be a vital factor for the formation edema of nasal polyps. (2) The effects of Fluticasone propionate on nasal polyps may be related to changing the expression of AQP-5 to a degree. (3) The full exploration of regulation and control of Aquaporions can contribute to evaluate the pathogenesis of nasal polyps.
authors.affiliation: Department of Otolaryngology, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Zhihai
authors.initials: Z
authors.lastname: Li
authors.forename: Qixue
authors.initials: Q
authors.lastname: Gao
authors.forename: Hongtao
authors.initials: H
authors.lastname: Zhen
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Cui
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051402:Aquaporin 5 / Q000096:biosynthesis*; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D051402:Aquaporin 5; D000068298:Fluticasone