title: Epithelioid angiomyolipoma of the kidney.
abstract: Epithelioid angiomyolipoma is a recently recognized variant of angiomyolipoma, which is characterized by the presence of polygonal cells with densely eosinophilic cytoplasm and varying degrees of nuclear atypia. Only a relatively small number of cases of epithelioid angiomyolipoma of the kidney have been reported in the literature. We report a case of epithelioid angiomyolipoma of the kidney that occurred in a 38-year-old woman. The tumor was composed of diffuse sheets of epithelioid cells, adipocytes and only scattered thick-walled blood vessels. The epithelioid cells had pleomorphic and hyperchromatic nuclei with densely eosinophilic cytoplasm. Hemorrhage, necrotic foci and clusters of foamy macrophages were present. HMB-45, CD117 (c-kit) and CD68 were detected in the epithelioid cells. There was no expression of cytokeratin, epithelial membrane antigen or desmin. The patient showed no evidence of recurrence or metastatic disease 9 months after nephrectomy.
authors.affiliation: Osmangazi University Medical Faculty, Department of Pathology, Eskisehir, Turkey. acikalin@ogu.edu.tr
authors.forename: Mustafa Fuat
authors.initials: MF
authors.lastname: Acikalin
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Tel
authors.forename: Ulkü
authors.initials: U
authors.lastname: Oner
authors.forename: Ozgül
authors.initials: O
authors.lastname: Pasaoglu
authors.forename: Turgut
authors.initials: T
authors.lastname: Dönmez
mesh_terms: D017667:Adipocytes / Q000473:pathology; D000328:Adult; D018207:Angiomyolipoma / Q000473:pathology* / Q000601:surgery; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D000951:Antigens, Neoplasm / Q000378:metabolism; D015622:Epithelioid Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008264:Macrophages / Q000473:pathology; D058950:Melanoma-Specific Antigens; D009336:Necrosis; D009363:Neoplasm Proteins / Q000378:metabolism; D009392:Nephrectomy; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D019009:Proto-Oncogene Proteins c-kit; C067980:CD68 antigen, human; D000097382:CD68 Molecule