title: Verucciform xanthoma of the penis not associated with human papillomavirus infection.
abstract: Verruciform xanthoma (VX) is a rare lesion with a predilection for oral mucosa. Only 16 cases of VX of the penis have been reported. Histologically, VX lesions in different locations are identical; however, the etiology is controversial. Previous studies have reported the presence of human papillomavirus (HPV) in VX of the skin. The purpose of this study was to determine whether HPV is a causative agent in this rare case of VX of the penis. Microscopically, the lesion demonstrated prominent verrucoid squamous hyperplasia with hyperkeratosis, parakeratosis, and acanthosis. Histiocytes, a hallmark of VX, were identified in the elongated dermal papillae. Nested polymerase chain reaction was performed on the DNA with the commonly used primer sets MY9/MY11 and GP5+/GP6+, which identify more than 40 HPV types. The results failed to identify HPV DNA in the sample, although HPV could be readily detected in genomic DNA extracted from paraffin-embedded condyloma acuminatum, a known HPV-associated lesion. Additionally, we tested a VX lesion of the palate for HPV DNA and obtained negative results. Our results indicate that VX can arise without HPV infection and suggest other possible origins may be involved.
authors.affiliation: Department of Pathology, Loyola University Medical Center, Maywood, Ill 60153, USA. cersahin@lumc.edu
authors.forename: Cağatay
authors.initials: C
authors.lastname: Erşahin
authors.forename: Anna M
authors.initials: AM
authors.lastname: Szpaderska
authors.forename: Kimberly
authors.initials: K
authors.lastname: Foreman
authors.forename: Sherri
authors.initials: S
authors.lastname: Yong
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis; D010409:Penile Diseases / Q000175:diagnosis*; D014973:Xanthomatosis / Q000175:diagnosis*