Resolution of peanut allergy following bone marrow transplantation for primary immunodeficiency.
Peanut allergy is a severe and life-threatening form of food allergy. Treatments are being developed but the mainstays of current management remain avoidance of peanut and appropriate use of rescue medication. We report the case of a boy with peanut allergy who required a bone marrow transplant (BMT) for combined immunodeficiency. A food challenge, 2 years after transplant, showed that his peanut allergy had resolved. Allergic disorders constitute a form of immune deviation and while we do not advocate BMT as a treatment for peanut allergy, we believe this case provides an insight into the basic mechanisms involved in food allergy.
Hourihane
J O'B
JO
Division of Infection, Inflammation and Repair, University of Southampton, Southampton, UK.
Rhodes
H L
HL
Jones
A M
AM
Veys
P
P
Connett
G J
GJ
D016026:Bone Marrow Transplantation; D002648:Child; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000601:surgery*; D008297:Male; D021183:Peanut Hypersensitivity / Q000503:physiopathology*; D011184:Postoperative Period; D012074:Remission Induction