Mesenchymal stem cells in the infarcted heart.
A loss of functional cardiomyocytes forms the cellular basis of cardiac dysfunction and heart failure. Stem cell based repletion of scarred myocardial tissue and regeneration of cardiomyocytes have been proposed as a potential treatment of ventricular dysfunction. In this review, we provide an overview of recent studies utilizing mesenchymal stem cells in cardiac regeneration and post-myocardial infarct therapy.
Jain
Mohit
M
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02118, USA.
Pfister
Otmar
O
Hajjar
Roger J
RJ
Liao
Ronglih
R
D000818:Animals; D006321:Heart / Q000502:physiology; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D012038:Regeneration / Q000502:physiology