title: Hormonal treatment of a recurrent granulosa cell tumor of the ovary: case report and review of the literature.
abstract: BACKGROUND
  Granulosa cell tumors of the ovary are rare, primarily treated surgically. In advanced or recurrent disease, data are inconclusive regarding the benefit of either primary or adjuvant chemotherapy. Hormonal therapy has been suggested as an alternative treatment.
  
  
  METHODS
  Our patient had three recurrences of estrogen receptor negative and progesterone receptor positive GCT, the first two treated by surgery with or without adjuvant chemotherapy. For the third recurrence, the patient received alternating biweekly cycles of megestrol and tamoxifen. Computed tomography showed stable disease at 6 months, partial response at 18 months, and complete response at 22 months. The patient continues on hormonal therapy and has been disease-free for 5 years.
  
  
  CONCLUSIONS
  This study and others suggest that hormonal therapy may provide another option for treating these relatively rare tumors.
authors.affiliation: Department of Obstetrics and Gynecology, Riverside Methodist Hospitals, Columbus, OH 43214, USA. idhardy@att.net
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Hardy
authors.forename: Jeffrey G
authors.initials: JG
authors.lastname: Bell
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Nicely
authors.forename: Gary C
authors.initials: GC
authors.lastname: Reid
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006106:Granulosa Cell Tumor / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008535:Megestrol / Q000008:administration & dosage; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery; D013629:Tamoxifen / Q000008:administration & dosage
chemical_list: D013629:Tamoxifen; D008535:Megestrol