Short report: neonatal screening pilot study of Toxoplasma gondii congenital infection in Mexico.
Congenital toxoplasmosis is an obstetric problem in Mexico, but its actual frequency is unknown. Using a network for screening of non-infectious disorders, we performed a pilot study to determine the frequency of IgM antibodies to Toxoplasma gondii in 1,003 infants (53.1% male, mean +/- SD age = 18.3 +/- 13.0 days, birth weight = 3.116 +/- 0.453 kg) in Mexico City from March to April 2003. Blood samples embedded in filter paper were assayed for IgM antibodies using a capture enzyme-linked immunosorbent assay and results were confirmed by Western blot. Two asymptomatic newborns, one of them premature, had IgM and IgG antibodies in a serum sample taken from both the infant and the mother and were clinically followed. Our data suggest a frequency of approximately two cases of congenital T. gondii infection per 1,000 newborns in Mexico City.
Vela-Amieva
Marcela
M
Servicio de Genética de la Nutrición, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City, Mexico. amieva@servidor.unam.mx <amieva@servidor.unam.mx>
Cañedo-Solares
Irma
I
Gutiérrez-Castrellón
Pedro
P
Pérez-Andrade
Martha
M
González-Contreras
Claudia
C
Ortíz-Cortés
Joel
J
Ortega-Velázquez
Venancio
V
Galván-Ramírez
Maria de la Luz
Mde L
Ruiz-García
Matilde
M
Saltigeral-Simentel
Patrica
P
Ordaz-Favila
Juan Carlos
JC
Sánchez
Carmen
C
Correa
Dolores
D
D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D010865:Pilot Projects; D015995:Prevalence; D012307:Risk Factors; D014122:Toxoplasma / Q000276:immunology; D014125:Toxoplasmosis, Congenital / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control* / Q000635:transmission
D000913:Antibodies, Protozoan