Differences in anxiety-related behavior between apolipoprotein E-deficient C57BL/6 and wild type C57BL/6 mice.
The influence of ApoE gene deletion on the anxiety state has not been previously investigated. The elevated plus maze was used in this study to determine differences in anxiety-related behavior between apoE-deficient and wild type C57BL/6 mice. The apoE-deficient mice demonstrated less anxiety on the elevated plus maze by spending more time in the open arms of the elevated plus maze compared to wild type mice (p<0.001). Additionally, female apoE-deficient mice visited the open arm of the maze more often than their apoE-deficient male counterpart (p<0.05). The anxiety state and/or sex are possible variables to be considered when designing physiological and/or behavioral studies involving mice that are apoE-deficient.
McLachlan
C S
CS
Department of Pharmacology, National Unviersity of Singapore. reperfusion@hotmail.com
Yi Xing Soh
C
C
D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D001057:Apolipoproteins E / Q000172:deficiency* / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D012737:Sex Factors
D001057:Apolipoproteins E