Do selective cyclo-oxygenase-2 inhibitors have a future?
The dramatic withdrawal of rofecoxib on 30 September 2004, along with safety concerns about other cyclo-oxygenase (COX)-2 inhibitors (especially valdecoxib), raises important issues for clinicians, pharmaceutical companies and regulatory authorities. Some of these are examined in this article, including: (i) was the cardiotoxicity of rofecoxib evident long before its withdrawal?; (ii) is the thrombotic hazard a class effect that is applicable to all COX-2 inhibitors?; (iii) may conventional NSAIDs also confer a risk of cardiovascular thrombosis?; and (iv) is there any future for selective COX-2 inhibitors?
Bannwarth
Bernard
B
Department of Rheumatology, Pellegrin Hospital, Victor Segalen University, Bordeaux, France. bernard.bannwarth@u-bordeaux2.fr
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002318:Cardiovascular Diseases / Q000139:chemically induced; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D006801:Humans; D011358:Product Surveillance, Postmarketing / Q000191:economics / Q000379:methods; D011720:Pyrazoles / Q000009:adverse effects; D013449:Sulfonamides / Q000009:adverse effects; D013927:Thrombosis / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib
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