title: Infant botulism, type F, presenting at 54 hours of life.
abstract: We report a case of botulism in a 54-hour-old infant with rapidly progressive fulminant paralysis and rapid spontaneous recovery atypical for infant botulism. Clostridium baratii and type F botulinum neurotoxin were isolated from the patient's stool. This unique presentation with rapid recovery is consistent with pharmacokinetics of type F botulinum neurotoxin. Interestingly, a muscle biopsy also revealed pathologic changes early in the disease course. This article reports the youngest known case of infant botulism and only the third reported case of this disease caused by type F neurotoxin. Botulism should be considered in patients of any age with subacute or acute neuromuscular weakness.
authors.affiliation: University of California-San Francisco (UCSF) School of Medicine, 521 Parnassus Avenue, San Francisco, CA 94143-0663, USA.
authors.forename: Corinne A
authors.initials: CA
authors.lastname: Keet
authors.forename: Christine K
authors.initials: CK
authors.lastname: Fox
authors.forename: Marta
authors.initials: M
authors.lastname: Margeta
authors.forename: Elysa
authors.initials: E
authors.lastname: Marco
authors.forename: Andi L
authors.initials: AL
authors.lastname: Shane
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Dearmond
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Strober
authors.forename: Steven P
authors.initials: SP
authors.lastname: Miller
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D001906:Botulism / Q000382:microbiology* / Q000473:pathology / Q000503:physiopathology; D047971:Clostridium botulinum type F; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D020127:Recovery of Function; D012720:Severity of Illness Index; D013997:Time Factors