Atypical forms of multiple sclerosis or different phases of a same disease?
Multiple sclerosis (MS) patients complain with the first symptoms of the disease in a range period which varies from childhood to adult life. The extent to which clinical presentation, disease course and demographic features may differ between childhood and adult onset has been the object of investigation. This paper aims to demonstrate that the different clinical phenotypes in young and old patients might simply reflect different phases of a same pathological process.
Trojano
M
M
Department of Neurological and Psychiatric Sciences, University of Bari, Italy. mtrojano@neurol.uniba.it
Paolicelli
D
D
Bellacosa
A
A
Fuiani
A
A
Cataldi
S
S
Di Monte
E
E
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003711:Demyelinating Diseases / Q000453:epidemiology / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000503:physiopathology*; D012189:Retrospective Studies; D012720:Severity of Illness Index