title: Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs.
abstract: Sublethal infection of C57BL/6 mice with Salmonella enterica serovar Typhimurium M525P initiates a strong inflammatory response. We measured organ expression of mRNA for Toll-like receptors and their associated signaling molecules during S. enterica serovar Typhimurium infection. During infection, the Toll-lie receptor 1 (TLR1), TLR2, and TLR9 mRNA levels increased, while TLR6 mRNA expression decreased.
authors.affiliation: Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom.
authors.forename: Sabine
authors.initials: S
authors.lastname: Tötemeyer
authors.forename: Pete
authors.initials: P
authors.lastname: Kaiser
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Maskell
authors.forename: Clare E
authors.initials: CE
authors.lastname: Bryant
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D015536:Down-Regulation; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009928:Organ Specificity; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D012481:Salmonella Infections, Animal / Q000382:microbiology / Q000503:physiopathology*; D012486:Salmonella typhimurium / Q000472:pathogenicity*; D051194:Toll-Like Receptor 1; D051195:Toll-Like Receptor 2; D051216:Toll-Like Receptor 6; D051217:Toll-Like Receptor 9; D051193:Toll-Like Receptors; D015854:Up-Regulation
chemical_list: D004268:DNA-Binding Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C493486:Tlr2 protein, mouse; C495369:Tlr6 protein, mouse; C495370:Tlr9 protein, mouse; D051194:Toll-Like Receptor 1; D051195:Toll-Like Receptor 2; D051216:Toll-Like Receptor 6; D051217:Toll-Like Receptor 9; D051193:Toll-Like Receptors
references.citation: Immunity. 1999 Oct;11(4):443-51
references.pmid: 10549626
references.citation: J Biol Chem. 1999 Jun 18;274(25):17406-9
references.pmid: 10364168
references.citation: Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13766-71
references.pmid: 11095740
references.citation: J Immunol. 2001 Jan 1;166(1):15-9
references.pmid: 11123271
references.citation: Nature. 2000 Dec 7;408(6813):740-5
references.pmid: 11130078
references.citation: Nature. 2001 Apr 26;410(6832):1099-103
references.pmid: 11323673
references.citation: Int Immunol. 2001 Jul;13(7):933-40
references.pmid: 11431423
references.citation: J Immunol. 2001 Jul 15;167(2):987-94
references.pmid: 11441107
references.citation: J Immunol. 2001 Aug 15;167(4):1882-5
references.pmid: 11489966
references.citation: Microbes Infect. 2001 Jul;3(9):771-6
references.pmid: 11489426
references.citation: J Immunol. 2001 Dec 15;167(12):7069-76
references.pmid: 11739528
references.citation: J Immunol. 2003 Jun 1;170(11):5445-54
references.pmid: 12759420
references.citation: Expert Opin Pharmacother. 2003 Jul;4(7):1105-19
references.pmid: 12831337
references.citation: Clin Microbiol Rev. 2003 Jul;16(3):379-414
references.pmid: 12857774
references.citation: Infect Immun. 2003 Nov;71(11):6653-7
references.pmid: 14573691
references.citation: J Immunol. 2004 Apr 1;172(7):4463-9
references.pmid: 15034062
references.citation: J Biol Chem. 2004 Sep 17;279(38):39727-35
references.pmid: 15190057
references.citation: Cell Immunol. 1986 Oct 1;102(1):68-77
references.pmid: 3542230
references.citation: Microb Pathog. 1990 Feb;8(2):135-41
references.pmid: 2112220
references.citation: Microb Pathog. 1991 Jul;11(1):33-8
references.pmid: 1795626
references.citation: Infect Immun. 1996 Jan;64(1):189-96
references.pmid: 8557339
references.citation: Science. 1998 Dec 11;282(5396):2085-8
references.pmid: 9851930
references.citation: J Exp Med. 2000 Jul 17;192(2):237-48
references.pmid: 10899910