[Experimental study of ortho-toluidine carcinogenicity].
Ortho-toluidine carcinogenicity has been tested in chronic experiments using mice, rats and dogs. Tumors were induced in 19% of mice (lung and kidney adenomas, leukemia), rats--40% (subcutaneous fat tumors, mammary fibroadenomas, leukemia, renal tumors and hepatic sarcoma). Bladder tumors developed in two dogs after 9 and 10 years of experiment. Both literature and experimental evidence point to o-toluidine as a hazard to humans.
Pliss
G B
GB
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004285:Dogs; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D014052:Toluidines / Q000633:toxicity*
D002273:Carcinogens; D014052:Toluidines; C023622:2-toluidine