title: Microfluidic operations using deformable polymer membranes fabricated by single layer soft lithography.
abstract: We show that it is possible to use single layer soft lithography to create deformable polymer membranes within microfluidic chips for performing a variety of microfluidic operations. Single layer microfluidic chips were designed, fabricated, and characterized to demonstrate pumping, sorting, and mixing. Flow rates as high as 0.39 microl min(-1) were obtained by peristaltic pumping using pneumatically-actuated membrane devices. Sorting was attained via pneumatic actuation of membrane units placed alongside the branch channels. An active mixer was also demonstrated using single-layer deformable membrane units.
authors.affiliation: Precision Biology, CTM/Intel Research, Intel Corp., 2200 Mission College Blvd., Santa Clara, CA 95054, USA. narayan.sundararajan@intel.com
authors.forename: Narayan
authors.initials: N
authors.lastname: Sundararajan
authors.forename: Dongshin
authors.initials: D
authors.lastname: Kim
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Berlin
mesh_terms: D004867:Equipment Design; D007260:Infusion Pumps; D008567:Membranes, Artificial; D008832:Microchemistry / Q000295:instrumentation / Q000379:methods; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D044085:Microfluidics / Q000295:instrumentation / Q000379:methods; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008567:Membranes, Artificial; D011108:Polymers