Near-infrared spectroscopy of the visual cortex in unilateral optic neuritis.
OBJECTIVE
To examine the occipital-lobe activation of patients with optic neuritis using near-infrared spectroscopy.


METHODS
Experimental study.


METHODS
NIRS was performed on five patients with acute unilateral optic neuritis during monocular visual stimulation. As controls, six normal subjects were also tested in the same manner.


RESULTS
In the patients with optic neuritis, the changes in the hemoglobin concentrations (oxyhemoglobin, deoxyhemoglobin, and total hemoglobin) in the occipital lobe were found to be markedly reduced when the clinically affected eyes were stimulated compared with the fellow eyes. The response induced by the stimulation of the affected eye was decreased, even when the patient's visual acuity improved to 20/20 in the recovery phase. There was no difference in the concentration changes between the two eyes in the control subjects.


CONCLUSIONS
NIRS may be useful in detecting visual dysfunction objectively and noninvasively in patients with visual disturbance, especially when used at the bedside.
Miki
Atsushi
A
Division of Ophthalmology and Visual Sciences, Niigata University, Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan. amiki@tc5.so-net.ne.jp
Nakajima
Takashi
T
Takagi
Mineo
M
Usui
Tomoaki
T
Abe
Haruki
H
Liu
Chia-Shang J
CS
Liu
Grant T
GT
D000293:Adolescent; D000328:Adult; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009902:Optic Neuritis / Q000175:diagnosis* / Q000378:metabolism; D010108:Oxyhemoglobins / Q000378:metabolism; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D014786:Vision Disorders / Q000175:diagnosis* / Q000378:metabolism; D014792:Visual Acuity; D014793:Visual Cortex / Q000378:metabolism / Q000473:pathology*
D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin