title: [Study on genetic polymorphism of NQO1 and susceptibility to benzene poisoning].
abstract: OBJECTIVE
  To explore the relationship between genetic polymorphism of NQO1 and susceptibility to benzene poisoning (BP).
  
  
  METHODS
  The genetic polymorphism of NQO1 for 100 patients with benzene poisoning and 90 workers exposed to benzene who were engaged in the same working time and job title as patients with benzene poisoning were detected by PCR-RFLP.
  
  
  RESULTS
  There was a 2.82-fold (95% CI: 1.42-5.58 ) increased risk of BP in the subjects with NQO1 C609T mutation genotype (T/T) compared with those carrying heterozygous (C/T) and wild type (C/C), and there was a 2.94-fold (95% CI: 1.25-6.90) increased risk of BP in the subjects with NQO1 C609T mutation genotype (T/T) compared with those carrying wild type (C/C) . There was a trend that the risk of BP in subjects with NQO1 C609T mutation genotype (T/T) was higher than those carrying heterozygous (C/T) and even higher than those carrying wild type (C/C) (chi2(trend) = 6.01, P = 0.014).
  
  
  CONCLUSIONS
  The subjects with NQO1 C609T mutation genotype (T/T) were more susceptive to benzene and NQO1 is as a biomarker to assessment the risk of benzene poisoning for individual.
authors.affiliation: Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Ji
authors.forename: Jianning
authors.initials: J
authors.lastname: Xu
authors.forename: Chunling
authors.initials: C
authors.lastname: Wu
authors.forename: Guilan
authors.initials: G
authors.lastname: Li
mesh_terms: D001554:Benzene / Q000506:poisoning*; D005838:Genotype; D006801:Humans; D009154:Mutation; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D009784:Occupational Diseases / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human; D001554:Benzene