title: Systematic approach to the analysis of cross-sectional imaging for surveillance of recurrent colorectal cancer.
abstract: Recurrent disease in colorectal cancer occurs in approximately 50% of patients who undergo a "curative" operation. Tumor recurrence may occur locally (at the anastomotic site), in the mesentery or mesocolon adjacent to the post-operative site, in the nodal echelon downstream to the post-operative site, and as distant metastases to the peritoneal cavity, liver or lung. Local recurrence at the anastomosis is frequently diagnosed at follow-up endoscopic examinations as part of screening for metachronous lesions. Other types of recurrences require imaging studies, most frequently CT or MR imaging to diagnose. We developed an approach to analyze imaging obtained after curative resection of colorectal cancer. Our approach is based on the knowledge of patterns of disease spread, of types of surgical procedures and of pathologic staging. Using this approach has the potential to detect recurrent disease at an early stage because the locoregional and nodal spread of this disease is predictable. Early diagnosis of recurrent disease, even in asymptomatic cases, allows for more effective treatment that can improve the long-term survival of these patients.
authors.affiliation: Department of Diagnostic Radiology, Division of Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Department of Diagnostic Radiology, 1515 Holcombe Blvd., Box 57, Houston, TX 77030, USA.
authors.forename: Silvana C
authors.initials: SC
authors.lastname: Faria
authors.forename: Eric P
authors.initials: EP
authors.lastname: Tamm
authors.forename: Vithya
authors.initials: V
authors.lastname: Varavithya
authors.forename: Sith
authors.initials: S
authors.lastname: Phongkitkarun
authors.forename: Harmeet
authors.initials: H
authors.lastname: Kaur
authors.forename: Janio
authors.initials: J
authors.lastname: Szklaruk
authors.forename: Ronelle
authors.initials: R
authors.lastname: Dubrow
authors.forename: Chusilp
authors.initials: C
authors.lastname: Charnsangavej
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D003952:Diagnostic Imaging; D006801:Humans; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*