Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.
A virulence plasmid was identified in a multidrug-resistant Salmonella enterica serotype Typhimurium strain carrying the spvC, rck, and pefA virulence genes and two class 1 integrons linked to the Tn21 and Tn1696 transposons. A novel trimethoprim resistance gene, designated dfrA23, was also identified within the integron region. The association of multidrug resistance and virulence determinants represents an interesting example of virulence plasmid evolution.
Villa
Laura
L
Department of Infectious, Parasitic, and Immuno-mediated Disease, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Carattoli
Alessandra
A
D000595:Amino Acid Sequence; D004251:DNA Transposable Elements; D024901:Drug Resistance, Multiple, Bacterial; D032023:Integrons; D008969:Molecular Sequence Data; D010957:Plasmids; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity*; D014774:Virulence
D004251:DNA Transposable Elements
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