Interindividual reproducibility of glutamate quantification using 1.5-T proton magnetic resonance spectroscopy.
The goal of this study was to measure the interindividual reproducibility of glutamate quantification in 1.5-T (1)H MRS of human brains. To determine the effective echo time (TE) for glutamate quantification, spectra from a phantom and 12 participants were obtained with TE = 30, 35, 40, and 144 ms (repetition time (TR) = 2000 ms and volume of interest = 4 cm(3)). The average Cramer-Rao lower bounds for glutamate quantification using LCModel was lowest in two experiments when TE = 40 ms.Twenty-one subjects participated in experiments that measured interindividual reproducibility of glutamate quantification. Spectra were acquired with TR = 6000 ms and TE = 40 ms. Results showed that the coefficients of variance were 11.0 and 13.1% in the anterior cingulate cortex and insula, respectively. This suggests that glutamate can be reproducibly measured from 1.5-T (1)H MRS with long TR, effective TE, and the LCModel.
Jang
Dong-Pyo
DP
Department of Biomedical Engineering, Hanyang University, 17 Heangdang-dong, Sungdong-ku, Seoul 133-791, Korea.
Lee
Jong-Min
JM
Lee
Eun
E
Park
Sangjin
S
Kim
Jae-Jin
JJ
Namkoong
Kee
K
Yoon
Kang-Jun
KJ
Kim
In-Young
IY
Kim
Sun I
SI
D000328:Adult; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D015203:Reproducibility of Results
D018698:Glutamic Acid