title: Chromosomal organization is shaped by the transcription regulatory network.
abstract: Transcription regulation, a key step in the control of gene expression, has been the focus of several large-scale studies; however, little attention has been given to its relationship with the chromosomal arrangement of transcription units. We studied this relationship systematically in Escherichia coli and Saccharomyces cerevisiae using network analysis methods. Our analysis reveals links between transcription regulation and chromosomal organization, suggesting that in both organisms transcription regulation has shaped the organization of transcription units on the chromosome. Differences found between the organisms reflect the inherent differences in transcription regulation between prokaryotes and eukaryotes.
authors.affiliation: Department of Molecular Genetics and Biotechnology, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel.
authors.forename: Ruth
authors.initials: R
authors.lastname: Hershberg
authors.forename: Esti
authors.initials: E
authors.lastname: Yeger-Lotem
authors.forename: Hanah
authors.initials: H
authors.lastname: Margalit
mesh_terms: D002876:Chromosomes, Bacterial / Q000235:genetics*; D015825:Chromosomes, Fungal / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors