Adenocarcinoma arising in a tailgut cyst with prominent meningothelial proliferation and thyroid tissue: case report and review of the literature.
Tailgut cysts (retrorectal cystic hamartomas) are rare lesions occurring in the retrorectal/presacral space of young women, considered to be of developmental origin. In this study, we report the clinicopathological characteristics of an adenocarcinoma developing in an unusual tailgut cyst. A 47-year-old female presented with a 3-month history of an enlarging presacral mass, extending into the gluteal area. The patient underwent surgical resection. Microscopic examination revealed a mucinous adenocarcinoma with intestinal features arising in a tailgut cyst. In addition to the usual components previously described in this lesion (cuboidal, columnar, ciliated or squamous epithelial lining with scattered smooth muscle fibers in the wall), our case was unique in that it was associated with a meningothelial proliferation and benign thyroid tissue with oncocytic changes. These additional features bring into question the proposed hindgut origin of tailgut cysts.
Andea
Aleodor A
AA
Memorial Sloan-Kettering Cancer Center, Department of Pathology, 1275 York Avenue, New York, NY 10021, USA.
Klimstra
David S
DS
D002288:Adenocarcinoma, Mucinous / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D002828:Choristoma / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006222:Hamartoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D012445:Sacrococcygeal Region / Q000473:pathology*; D013961:Thyroid Gland
Surg Today. 1998;28(12):1319-22
9872560
Br J Radiol. 2002 Jul;75(895):620-3
12145137
AJR Am J Roentgenol. 1998 Jun;170(6):1488-90
9609159
Am J Gastroenterol. 2000 May;95(5):1344-7
10811351
J Pediatr Surg. 2000 Dec;35(12 ):1833-5
11101749
Mt Sinai J Med. 1990 Sep;57(4):249-52
2247102
Clin Radiol. 1999 Feb;54(2):118-22
10050741
Cancer. 1999 Oct 1;86(7):1198-202
10506704
Radiographics. 2001 May-Jun;21(3):575-84
11353107
Arch Pathol Lab Med. 1993 Jul;117(7):724-8
8323438
Pediatr Surg Int. 1997 Jul;12(5-6):452-4
9244127
Arch Pathol. 1960 Jan;69:64-6
13813053
Arch Pathol Lab Med. 1984 Sep;108(9):737-40
6547827
Dis Colon Rectum. 1970 Mar-Apr;13(2):133-7
5441865
Am J Surg Pathol. 1982 Dec;6(8):707-14
7168459
Dis Colon Rectum. 1975 Oct;18(7):581-9
1181162
Am J Clin Pathol. 1988 Feb;89(2):139-47
3277378
AJNR Am J Neuroradiol. 1998 Jun-Jul;19(6):1043-5
9672009
Dis Colon Rectum. 1975 Oct;18(7):597-600
1181163
Eur J Surg. 1996 Feb;162(2):149-52
8639730
Dis Colon Rectum. 1970 Mar-Apr;13(2):127-32
5441864
Arch Pathol Lab Med. 2001 Oct;125(10):1361-4
11570917
Dis Colon Rectum. 2003 Mar;46(3):411-3
12626920
Arch Pathol Lab Med. 2000 May;124(5):725-9
10782156
Dis Colon Rectum. 1985 Sep;28(9):644-52
2996861
Am J Surg Pathol. 1998 Feb;22(2):251-5
9500228
Neurosurgery. 1994 Dec;35(6):1163-7
7885566
Am Surg. 1995 Nov;61(11):997-1000
7486435
Am J Roentgenol Radium Ther Nucl Med. 1973 Feb;117(2):307-13
4685860
J Pediatr Surg. 1990 Sep;25(9):980-4
2213451
J Clin Pathol. 1999 Apr;52(4):310-2
10474528
Histopathology. 1991 Mar;18(3):265-6
2045078
AJR Am J Roentgenol. 1986 Dec;147(6):1309-11
3535460