title: The effect of fosfomycin on nedaplatin-induced nephrotoxicity in rats.
abstract: The effect of coadministration of fosfomycin (FOM) on nedaplatin-induced nephrotoxicity in rats was investigated for 6 days. FOM decreased nedaplatin-induced nephrotoxicity, as shown by reduced blood urea nitrogen (BUN), serum creatinine levels, and urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG). Further, there were fewer histopathological signs of nephrotoxicity in the groups treated with the combination of nedaplatin and FOM as compared with the nedaplatin-alone group. The concentration of nedaplatin was significantly lower in the renal cortex of rats treated with the combination of nedaplatin and FOM as compared with those treated with nedaplatin alone (p < 0.05). In conclusion, the concomitant administration of FOM and nedaplatin may help to achieve a chemotherapeutic strategy that reduces the nephrotoxic effects of nedaplatin.
authors.affiliation: Division of Clinical Pharmacy, Kyoritsu University of Pharmacy, 1-15-30 Shibakoen, Minato-ku, 105-8512, Tokyo, Japan. yoshiyama-yj@kyoritsu-ph.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yoshiyama
authors.forename: Kazue
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Minoru
authors.initials: M
authors.lastname: Kurokawa
authors.forename: Motoko
authors.initials: M
authors.lastname: Kanke
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D005578:Fosfomycin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009944:Organoplatinum Compounds; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009944:Organoplatinum Compounds; D005578:Fosfomycin; C053989:nedaplatin; D003404:Creatinine; D000118:Acetylglucosaminidase