Prescribing patterns of diuretics in multi-drug antihypertensive regimens.
Recent literature suggests that most hypertensives will require two or more drugs to achieve target blood pressure. Our objective was to estimate the proportion of patients receiving diuretics, including thiazides, for blood pressure control among those receiving two or more drugs. We studied 25,052 hypertensives in a tertiary care Veterans Affairs facility and identified individuals taking any thiazide or loop diuretic among patients receiving two, three, four, or more drugs. Rates of any diuretic use were 50%, 73%, and 89%, and decreased to 39.0%, 59.0%, and 72.5% for thiazide use, respectively. Rates of thiazide use were statistically significantly higher among African Americans compared with the general study population, but did not differ significantly in the elderly. Though overall diuretic use seems to be increasing as compared with previous studies, there is room for improvement in the use of thiazides in multi-drug hypertension regimens.
Singh
Hardeep
H
VA Medical Center (111PC), 2002 Holcombe Boulevard, Houston, TX 77030, USA. hardeeps@bcm.tmc.edu
Johnson
Michael L
ML
D000368:Aged; D000959:Antihypertensive Agents / Q000145:classification / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D004232:Diuretics / Q000145:classification / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D017723:Drug Utilization Review; D005260:Female; D006787:Hospitals, Veterans; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians'; D012189:Retrospective Studies; D014481:United States
D000959:Antihypertensive Agents; D004232:Diuretics
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