title: Experimental tooth movement upregulates preproenkephalin mRNA in the rat trigeminal nucleus caudalis and oralis.
abstract: Levels of preproenkephalin mRNA expression in trigeminal subnucleus complex by noxious tooth movement stimuli were examined using in situ hybridization. At 24 h, preproenkephalin mRNA expression was significantly upregulated in the ipsilateral trigeminal subnucleus caudalis (P<0.05), and in the subnucleus oralis (P<0.05). These findings suggested that enkephalinergic inhibitory systems could be activated during tooth movement, and that subnucleus oralis may be involved in modulation of the nociception, as well as the subnucleus caudalis.
authors.affiliation: Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-Cho, Okayama 700-8525, Japan.
authors.forename: Tarek A
authors.initials: TA
authors.lastname: Balam
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamashiro
authors.forename: Li
authors.initials: L
authors.lastname: Zheng
authors.forename: Sakhr
authors.initials: S
authors.lastname: Murshid Ahmed
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Fujiyoshi
authors.forename: Teruko
authors.initials: T
authors.lastname: Takano-Yamamoto
mesh_terms: D000344:Afferent Pathways / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D004745:Enkephalins / Q000235:genetics* / Q000378:metabolism; D007839:Functional Laterality / Q000502:physiology; D008297:Male; D009433:Neural Inhibition / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D009967:Orthodontic Appliances / Q000009:adverse effects; D010146:Pain / Q000378:metabolism* / Q000503:physiopathology; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014070:Tooth / Q000294:innervation* / Q000502:physiology; D014275:Trigeminal Caudal Nucleus / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology
chemical_list: D004745:Enkephalins; D011498:Protein Precursors; D012333:RNA, Messenger; C033660:preproenkephalin