title: Effects of methylprednisolone on the neural conduction of the motor evoked potentials in spinal cord injured rats.
abstract: Methylprednisolone(MP), a glucocorticoid steroid, has an anti-inflammatory action and seems to inhibit the formation of oxygen free radicals produced during lipid peroxidation in a spinal cord injury(SCI). However, the effects of MP on the functional recovery after a SCI is controversial. The present study was conducted to determine the effects of MP on the recovery of neural conduction following a SCI. A SCI was produced using the NYU spinal cord impactor. A behavioral test was conducted to measure neurological disorders, and motor evoked potentials (MEPs) were recorded. According to the behavioral test, using BBB locomotor scaling, MP-treated animals showed improved functional recoveries when compared to saline-treated animals. MEP latencies in the MP-treated group were shortened when compared to those in the control group. Peak amplitudes of MEPs were larger in the MP-treated group than those in the control group. The thresholds of MEPs tended to be lower in the MP-treated group than those in the control group. These results suggest that MP may improve functional recovery after a SCI.
authors.affiliation: Department of Neurosurgery, Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Bae Hwan
authors.initials: BH
authors.lastname: Lee
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Lee
authors.forename: Do Heum
authors.initials: DH
authors.lastname: Yoon
authors.forename: Un Jeng
authors.initials: UJ
authors.lastname: Kim
authors.forename: Yong Soon
authors.initials: YS
authors.lastname: Hwang
authors.forename: Sang Keun
authors.initials: SK
authors.lastname: Park
authors.forename: Joong Uhn
authors.initials: JU
authors.lastname: Choi
authors.forename: Yong Gou
authors.initials: YG
authors.lastname: Park
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004594:Electrophysiology; D019054:Evoked Potentials, Motor / Q000187:drug effects*; D005609:Free Radicals; D005938:Glucocorticoids / Q000378:metabolism; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D005609:Free Radicals; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D012965:Sodium Chloride; D010100:Oxygen; D008775:Methylprednisolone
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