title: Marine actinomycetes as a source of novel secondary metabolites.
abstract: A set of 600 actinomycetes strains which were isolated from marine sediments from various sites in the Pacific and Atlantic Oceans were screened for the production of bioactive secondary metabolites. Marine streptomycete strains were found to be producers of well known chemically diverse antibiotics isolated from terrestrial streptomycetes, as in the case of marine Micromonospora strains. New marine members of the rare genus Verrucosispora seem to be a promising source for novel bioactive secondary metabolites as shown in the case of the abyssomicin producing strain AB-18-032.
authors.affiliation: Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany. hans-peter.fiedler@uni-tuebingen.de
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
authors.forename: Christina
authors.initials: C
authors.lastname: Bruntner
authors.forename: Alan T
authors.initials: AT
authors.lastname: Bull
authors.forename: Alan C
authors.initials: AC
authors.lastname: Ward
authors.forename: Michael
authors.initials: M
authors.lastname: Goodfellow
authors.forename: Olivier
authors.initials: O
authors.lastname: Potterat
authors.forename: Carsten
authors.initials: C
authors.lastname: Puder
authors.forename: Gerhard
authors.initials: G
authors.lastname: Mihm
mesh_terms: D000192:Actinomycetales / Q000145:classification / Q000254:growth & development / Q000302:isolation & purification* / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification*; D001267:Atlantic Ocean; D003470:Culture Media / Q000737:chemistry; D019015:Geologic Sediments / Q000382:microbiology*; D008848:Micromonosporaceae / Q000145:classification / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism; D015394:Molecular Structure; D010140:Pacific Ocean; D012623:Seawater
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media