title: Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors.
abstract: A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2.
authors.affiliation: ViroChem Pharma Inc., 275 Armand-Frappier Blvd., Laval, Québec, Canada H7V 4A7. gfalardeau@virochempharma.com
authors.forename: Guy
authors.initials: G
authors.lastname: Falardeau
authors.forename: Hugo
authors.initials: H
authors.lastname: Lachance
authors.forename: Annie
authors.initials: A
authors.lastname: St-Pierre
authors.forename: Constantin G
authors.initials: CG
authors.lastname: Yannopoulos
authors.forename: Marc
authors.initials: M
authors.lastname: Drouin
authors.forename: Jean
authors.initials: J
authors.lastname: Bédard
authors.forename: Laval
authors.initials: L
authors.lastname: Chan
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects*; D015195:Drug Design; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D009287:Naphthyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D009287:Naphthyridines