The normalization of total clearances for intravenous injection drugs.
There have been reports wherein the total clearance of certain drugs exceeded the blood flow rate when blood concentration data following an intravenous injection was used. It is theoretically unusual that for drugs carried to the tissue by blood, the quantity eliminated is larger than the quantity carried. Nevertheless, the problem about total clearance still needs to be solved. The present paper proposes an equation to ensure that such unusual values do not arise.
Nishiyama
Toshio
T
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe, Japan.
Iguch
Shin
S
D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*; D012016:Reference Values
D004364:Pharmaceutical Preparations
Xenobiotica. 2001 Aug-Sep;31(8-9):591-8
11569527
J Pharmacobiodyn. 1989 Oct;12(10):608-15
2630631