title: Microwave-assisted sequential amide bond formation and intramolecular amidation: a rapid entry to functionalized oxindoles.
abstract: A general method has been developed for the synthesis of N-substituted oxindoles. The two-step process involves initial microwave-assisted amide bond formation between 2-halo-arylacetic acids and various alkylamines and anilines, followed by a palladium-catalyzed intramolecular amidation under aqueous conditions. In the case of alkylamines, the procedure can be carried out as a one-pot process without isolation of the intermediate amide. [structure: see text]
authors.affiliation: School of Chemistry, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JJ, Scotland, UK.
authors.forename: Rajamohan R
authors.initials: RR
authors.lastname: Poondra
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Turner