Clinical relevance of non-neuronal auto-antibodies in patients with anti-Hu or anti-Yo paraneoplastic diseases.
About half of the patients with paraneoplastic diseases develop an immune response against neuronal antigens expressed by both the tumor and the nervous system. In 31 patients with anti-Hu antibodies and 19 patients with anti-Yo antibodies, we searched for the presence of additional non-neuronal auto-antibodies and further studied whether the presence of such auto-antibodies was correlated with a specific oncological or neurological presentation. Positive antinuclear antibodies (ANA) were found at a titer of 1:40 or above in 48% patients with anti-Hu antibodies, and in 37% patients with anti-Yo antibodies. Anti-cytoplasmic antibodies were also detected in 42% patients with anti-Yo antibodies. No specific correlation between the presence of non-neuronal auto-antibodies and clinical characteristics of the patients could be identified. In particular, neither the type of underlying cancer, the overall survival, the tumor response to treatment, nor the neurological presentation were related to the serological status.
Aguirre-Cruz
Lucinda
L
INSERM U 495 and Fédération de Neurologie Mazarin, Hôpital de la Pitié-Salpêtrière, Paris, France.
Charuel
Jean-Luc
JL
Carpentier
Antoine F
AF
Benyahia
Baya
B
Delattre
Jean-Yves
JY
Musset
Lucile
L
D000368:Aged; D000974:Antibodies, Antinuclear / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology; D018288:Carcinoma, Small Cell / Q000276:immunology; D004268:DNA-Binding Proteins / Q000276:immunology*; D051959:ELAV Proteins; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009474:Neurons / Q000276:immunology; D010051:Ovarian Neoplasms / Q000276:immunology; D020361:Paraneoplastic Syndromes, Nervous System / Q000276:immunology*; D011471:Prostatic Neoplasms / Q000276:immunology; D016601:RNA-Binding Proteins / Q000276:immunology*; D014571:Urologic Neoplasms / Q000276:immunology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; C095184:CDR2 protein, human; D004268:DNA-Binding Proteins; D051959:ELAV Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins
J Neurooncol. 2003 May;62(3):349-51
12777089
Neurology. 2001 Aug 14;57(3):558-9
11502940
Clin Chem Lab Med. 2000 Feb;38(2):117-22
10834398
J Neurol. 1996 Jan;243(1):51-6
8869387
Int Arch Allergy Appl Immunol. 1984;74(1):63-6
6608501
Arthritis Rheum. 1997 Sep;40(9):1601-11
9324014
Clin Cancer Res. 1999 Jun;5(6):1393-400
10389924