title: Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance.
abstract: A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against Streptococcus pneumoniae strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain.
authors.affiliation: Laboratory of Bacterial Pathogenesis, The Rockefeller University, 1230 York Ave., New York, NY 10021, USA.
authors.forename: Svetolik
authors.initials: S
authors.lastname: Djurkovic
authors.forename: Jutta M
authors.initials: JM
authors.lastname: Loeffler
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Fischetti
mesh_terms: D004357:Drug Synergism; D005839:Gentamicins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000494:pharmacology*; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D005839:Gentamicins; D010406:Penicillins; D009238:N-Acetylmuramoyl-L-alanine Amidase
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