title: A stromal address code defined by fibroblasts.
abstract: To navigate into and within tissues, leukocytes require guidance cues that enable them to recognize which tissues to enter and which to avoid. Such cues are partly provided at the time of extravasation from blood by an endothelial address code on the luminal surface of the vascular endothelium. Here, we review the evidence that fibroblasts help define an additional stromal address code that directs leukocyte behaviour within tissues. We examine how this stromal code regulates site-specific leukocyte accumulation, differentiation and survival in a variety of physiological stromal niches, and how the aberrant expression of components of this code in the wrong tissue at the wrong time contributes to the persistence of chronic inflammatory diseases.
authors.affiliation: Rheumatology Research Group, Institute of Biomedical Research, MRC Center for Immune Regulation, University of Birmingham, UK, B15 2TT.
authors.forename: Greg
authors.initials: G
authors.lastname: Parsonage
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Filer
authors.forename: Oliver
authors.initials: O
authors.lastname: Haworth
authors.forename: Gerard B
authors.initials: GB
authors.lastname: Nash
authors.forename: G Ed
authors.initials: GE
authors.lastname: Rainger
authors.forename: Michael
authors.initials: M
authors.lastname: Salmon
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Buckley
mesh_terms: D003713:Dendritic Cells / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology / Q000502:physiology; D005347:Fibroblasts / Q000276:immunology* / Q000502:physiology; D007962:Leukocytes / Q000276:immunology / Q000502:physiology; D008954:Models, Biological; D017154:Stromal Cells / Q000276:immunology* / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology
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