title: Strategies for improving the diagnostic specificity of the frequency doubling perimeter.
abstract: OBJECTIVE
  To evaluate various strategies designed to improve the specificity of the interpretation of results obtained with the frequency doubling technology perimeter (FDT) used in the full-threshold mode.
  
  
  METHODS
  Three different strategies were compared using data from 452 glaucoma patients and 237 healthy subjects: combining several FDT parameters from a single test, combining the FDT test with a GDx test, and confirming an abnormal FDT test result with a repeat test.
  
  
  RESULTS
  Confirming an abnormal FDT test result with a repeat test yielded a specificity increase of 0.10, from 0.80 to 0.90, at the expense of some loss of sensitivity for early but not for moderate or severe glaucoma. Combining several FDT parameters from a single test and combining FDT with GDx did not yield any noticeable increase in diagnostic performance.
  
  
  CONCLUSIONS
  A modest increase in FDT diagnostic performance can be obtained by the confirmation of an abnormal test result with a repeat test.
authors.affiliation: Department of Ophthalmology, University Hospital Groningen, 9700 RB Groningen, The Netherlands.
authors.forename: Govert P
authors.initials: GP
authors.lastname: Heeg
authors.forename: Remco
authors.initials: R
authors.lastname: Stoutenbeek
authors.forename: Nomdo M
authors.initials: NM
authors.lastname: Jansonius
mesh_terms: D015331:Cohort Studies; D005189:False Positive Reactions; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D009412:Nerve Fibers / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011336:Probability; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012680:Sensitivity and Specificity; D058609:Visual Field Tests / Q000379:methods*