title: Oprelvekin-associated bilateral optic disk edema.
abstract: OBJECTIVE
  To report a case of bilateral optic disk edema in a patient taking oprelvekin for radioimmunotherapy-induced thrombocytopenia.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  A 38-year-old man with a history of relapsed non-Hodgkins follicular lymphoma complained of bilateral loss of vision following oprelvekin therapy for thrombocytopenia.
  
  
  RESULTS
  Funduscopic examination demonstrated bilateral optic disk edema with exudates inferotemporal to the right nerve. The results of magnetic resonance imaging of the brain and orbits and lumbar puncture were normal. The disk edema resolved with discontinuation of oprelvekin therapy.
  
  
  CONCLUSIONS
  Oprelvekin therapy may be associated with bilateral optic disk edema. This has been shown to be reversible in a primate model.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Peterson
authors.forename: David J
authors.initials: DJ
authors.lastname: Inwards
authors.forename: Brian R
authors.initials: BR
authors.lastname: Younge
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D017370:Interleukin-11 / Q000009:adverse effects*; D008224:Lymphoma, Follicular / Q000532:radiotherapy; D008297:Male; D010211:Papilledema / Q000139:chemically induced*; D016499:Radioimmunotherapy / Q000009:adverse effects; D011994:Recombinant Proteins / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000188:drug therapy / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents; D017370:Interleukin-11; D011994:Recombinant Proteins; C105308:oprelvekin