[Brain metabolites ratio as a prospective marker in assessment of the therapy efficacy in children with epilepsy].
Influence of ratio between N-acetylaspartat (NAA) and myoinositol brain tissue metabolites as well as ratio beween myoinositol and kreatinine on the therapy efficacy in children with epilepsy has been studied by authors. The obtained results allowed detecting the derangement in one section of cerebral metabolism, recovery of which on the background of effective antiepileptic treatment finds its reflection in ratio between N-acetylaspartat (NAA) and myoinositol and between myoinositol and kreatinine.
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D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007294:Inositol / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D016896:Treatment Outcome
D000927:Anticonvulsants; D015415:Biomarkers; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate