Risperidone and breast-feeding.
We present the case of a breast-feeding woman with acute psychotic symptoms after delivery, which were treated with the antipsychotic agent risperidone. Serum levels of risperidone and 9-hydroxyrisperidone could be detected in both the mother and her infant. Drug-levels in breast milk were ten-fold lower compared to maternal serum. The patient responded well to antipsychotic treatment. Her infant did not display any adverse effects and psychomotor development was normal. In this case, risperidone was a safe treatment option for the breast-feeding mother and her infant. We also provide a brief overview of the clinically relevant data concerning antipsychotics and breast-feeding.
Aichhorn
W
W
Department of Psychiatry, University of Innsbruck, Innsbruck, Austria. wolfgang.aichhorn@uibk.ac.at
Stuppaeck
C
C
Whitworth
A B
AB
D000328:Adult; D014150:Antipsychotic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001942:Breast Feeding; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007555:Isoxazoles / Q000097:blood / Q000378:metabolism; D008895:Milk, Human / Q000378:metabolism; D000068882:Paliperidone Palmitate; D049590:Postpartum Period / Q000523:psychology*; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000378:metabolism*; D011743:Pyrimidines / Q000097:blood / Q000378:metabolism; D018967:Risperidone / Q000493:pharmacokinetics* / Q000627:therapeutic use
D014150:Antipsychotic Agents; D007555:Isoxazoles; D011743:Pyrimidines; D018967:Risperidone; D000068882:Paliperidone Palmitate