[Study of diffusion of muscone in different inclusion complexes and liposome through mouse (correction of rat) skin in vitro].
OBJECTIVE
To compare the penetrating rate of muscone in different inclusion complexes and liposome.


METHODS
The transdermal effect of muscone in different inclusion complexes and liposome was studied comparatively on mouse [corrected] skin with 40% EtOH as the absorption solution and with an improved Franz diffuse cell.


RESULTS
Among the different inclusion complexes and liposome, the penetrating rate of muscone in the HP-beta-cyclodextrin inclusion and the liposome were higher than muscone, and that of muscone in the beta-cyclodextrin inclusion is the lowest.


CONCLUSIONS
The HP-beta-cyclodextrin inclusion and the liposome can hence the muscone transdermal speed.
Di
Liu-qing
LQ
Nanjing university of Traditional Chinese Medicine, Nanjing 210029, China. diliuqing@yahoo.com.cn
Mao
Chun-qin
CQ
Xie
Hui
H
Guo
Rong
R
Xue
Ming
M
Yan
Ke
K
Zhang
Li
L
Li
Hong-yan
HY
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000818:Animals; D003516:Cycloparaffins / Q000008:administration & dosage / Q000493:pharmacokinetics; D004337:Drug Carriers; D004355:Drug Stability; D066298:In Vitro Techniques; D008081:Liposomes; D051379:Mice; D012869:Skin Absorption; D047392:beta-Cyclodextrins
D003516:Cycloparaffins; D004337:Drug Carriers; D008081:Liposomes; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C031021:muscone