[Influence of chemotherapy on Th1/Th2 cytokine switching in stomach cancer patients].
OBJECTIVE
To observe the influence of chemotherapy on the switching of Th1/Th2 cytokines in stomach cancer patients.


METHODS
Th1/Th2 cytokine genes expressed by peripheral blood mononuclear cells of stomach cancer patients before and after chemotherapy were detected by RT-PCR.


RESULTS
The expression of Th2 cytokines was dominant in patients before chemotherapy, and the dominancy became less marked after chemotherapy.


CONCLUSIONS
The immune deviation with Th2 predominance in stomach cancer patients has a tendency to become reversed after chemotherapy.
Li
Yan
Y
Department of Oncology, Qianfushan Hospital, Shandong Jinan 250014, China.
Liang
Jing
J
Liu
Wen-bo
WB
Xu
Xiao-qun
XQ
Zhao
Yue-ran
YR
D000230:Adenocarcinoma / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism*; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism*
D007378:Interleukins; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D007371:Interferon-gamma; D002955:Leucovorin; D005472:Fluorouracil