A new tactic to treat postprandial hyperlipidemia in diabetic rats with gastroparesis by improving gastrointestinal transit.
Improvement of gastrointestinal transit was thought to be a new tactic to treat postprandial hypertriglyceridemia in diabetic individuals with gastroparesis. Diabetic gastroparesis, lipid load testing, and the effect of domperidone or aqueous extract of rhizomes of Rheum palmatum L. on postprandial hypertriglyceridemia were evaluated in alloxan-induced diabetic rats. Alloxan diabetic animals had a slow gastrointestinal transit, together with delayed and exaggerated postprandial hypertriglyceridemia, after oral administration of olive oil, which was significantly improved after oral administration of domperidone or R. palmatum L. However, atropine could prevent the effects of R. palmatum L. The reduced postprandial hypertriglyceridemia was highly correlated with the improvement in gastrointestinal transit. These results suggest that promotion of gastrointestinal transit may be useful for the treatment of postprandial hypertriglyceridemia in diabetic patients with gastroparesis. R. palmatum L. may become a new choice for these patients since it has more potential benefits than domperidone.
Xie
Weidong
W
Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China.
Xing
Dongming
D
Zhao
Yunan
Y
Su
Hui
H
Meng
Zhen
Z
Chen
Yunyun
Y
Du
Lijun
L
D000284:Administration, Oral; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004294:Domperidone / Q000008:administration & dosage; D018492:Dopamine Antagonists / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D004386:Duodenum; D005753:Gastric Mucosa / Q000378:metabolism; D005772:Gastrointestinal Transit / Q000187:drug effects*; D018589:Gastroparesis / Q000188:drug therapy* / Q000209:etiology; D006949:Hyperlipidemias / Q000188:drug therapy*; D007274:Injections, Intraperitoneal; D007421:Intestine, Small / Q000187:drug effects / Q000502:physiology; D008297:Male; D000069463:Olive Oil; D010637:Phenolsulfonphthalein / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D010938:Plant Oils / Q000008:administration & dosage; D019518:Postprandial Period; D051381:Rats; D017208:Rats, Wistar; D012250:Rheum; D027343:Rhizome / Q000737:chemistry; D013270:Stomach / Q000187:drug effects; D013997:Time Factors
D018492:Dopamine Antagonists; D000069463:Olive Oil; D010936:Plant Extracts; D010938:Plant Oils; D004294:Domperidone; D010637:Phenolsulfonphthalein