title: Making a new turn in matrix metalloprotease inhibition.
abstract: The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode.
authors.affiliation: Incyte Corporation, Experimental Station, Route 141 and Henry Clay Road, Wilmington, Delaware 19880, USA
authors.forename: Zelda R
authors.initials: ZR
authors.lastname: Wasserman
mesh_terms: D002384:Catalysis; D020134:Catalytic Domain; D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases