title: Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis.
abstract: We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.
authors.affiliation: Department of Medicine, UMDNJ-New Jersey Medical School, 225 Warren St., Newark, NJ 07103, USA. venketvi@umdnj.edu
authors.forename: Vishwanath
authors.initials: V
authors.lastname: Venketaraman
authors.forename: Yaswant K
authors.initials: YK
authors.lastname: Dayaram
authors.forename: Meliza T
authors.initials: MT
authors.lastname: Talaue
authors.forename: Nancy D
authors.initials: ND
authors.lastname: Connell
mesh_terms: D000818:Animals; D002460:Cell Line; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology*; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development*; D026422:S-Nitrosoglutathione / Q000494:pharmacology*
chemical_list: D008070:Lipopolysaccharides; D026422:S-Nitrosoglutathione; D007371:Interferon-gamma; D005978:Glutathione
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