N-acetyl-L-Cysteine as prophylaxis against sulfur mustard.
Sulfur mustard (HD) is a blister agent targeting the eyes, respiratory system, skin, and possibly other organs. Extensive exposure can destroy the immune system by destruction of bone marrow cells. There is no antidote for HD or effective treatment other than rapid decontamination. Clinical trials have demonstrated activity for N-acetyl-L-cysteine (NAC) against a number of significant human pathologies involving free radicals, and animal and tissue studies have suggested efficacy for NAC as a chemoprotectant against many toxic chemicals. Among these are studies demonstrating that NAC significantly reduces the effects of HD and HD simulants, both in cultured cells and animals. Given the historical effectiveness of HD, the lack of any effective treatment, the demonstrated chemoprotective properties of NAC, its low toxicity, the lack of regulatory controls, and the data supporting efficacy against HD effects, we suggest daily oral administration of the maximum safe dose of NAC to personnel entering combat zones.
Bobb
Andrew J
AJ
Naval Health Research Center Detachment, Toxicology, 2729 R Street, Building 837, Area B, Wright Patterson AFB, OH 45433-7903, USA.
Arfsten
Darryl P
DP
Jederberg
Warren W
WW
D000111:Acetylcysteine / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity*; D018890:Chemoprevention; D006801:Humans; D009151:Mustard Gas / Q000633:toxicity*; D020011:Protective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D012449:Safety
D002619:Chemical Warfare Agents; D020011:Protective Agents; D009151:Mustard Gas; D000111:Acetylcysteine