title: Pharmacogenetics of anesthetic and analgesic agents.
abstract: Predicting a patient's response to a particular drug has long been a goal of clinicians. Rapid advances in molecular biology have enabled researchers to identify associations between an individual's genetic profile and drug response. Pharmacogenetics is the study of the molecular mechanisms that underlie individual differences in drug metabolism, efficacy, and side effects. The pharmacogenetics of commonly used anesthetic and analgesic agents are reviewed.
authors.affiliation: Department of Cardiovascular Anesthesia, Texas Heart Institute, St. Luke's Episcopal Hospital, Houston 77030, USA.
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Palmer
authors.forename: N Martin
authors.initials: NM
authors.lastname: Giesecke
authors.forename: Simon C
authors.initials: SC
authors.lastname: Body
authors.forename: Stanton K
authors.initials: SK
authors.lastname: Shernan
authors.forename: Amanda A
authors.initials: AA
authors.lastname: Fox
authors.forename: Charles D
authors.initials: CD
authors.lastname: Collard
mesh_terms: D000700:Analgesics / Q000378:metabolism / Q000494:pharmacology*; D000777:Anesthetics / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D009294:Narcotics / Q000378:metabolism / Q000494:pharmacology; D009466:Neuromuscular Blocking Agents / Q000378:metabolism / Q000494:pharmacology; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic
chemical_list: D000700:Analgesics; D000777:Anesthetics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009294:Narcotics; D009466:Neuromuscular Blocking Agents