title: A nutritional intervention promoting the Mediterranean food pattern is associated with a decrease in circulating oxidized LDL particles in healthy women from the Québec City metropolitan area.
abstract: The aim of the present study was to evaluate the effect of a nutritional intervention promoting the Mediterranean food pattern under free-living conditions on circulating oxidized LDL (ox-LDL) in a group of 71 healthy women from the Quebec City metropolitan area. The 12-wk nutritional intervention consisted of 2 courses on nutrition and 7 individual sessions with a dietitian. A score based on the 11 components of the Mediterranean pyramid was established to determine the women's adherence to the Mediterranean food pattern. Plasma ox-LDL concentrations were measured by a monoclonal antibody mAb-4E6-based competition ELISA. Among all women, plasma ox-LDL decreased by 11.3% after 12 wk of nutritional intervention (P < 0.0001) despite a lack of change in plasma LDL cholesterol (LDL-C). Also, an increase in the Mediterranean dietary score was significantly correlated with a decrease in ox-LDL concentrations (r = -0.30; P = 0.01). More specifically, increases in servings of fruits (r = -0.25; P < 0.05) and vegetables (r = -0.24; P < 0.05) were associated with decreases in ox-LDL concentrations. Changes in the food pattern in response to a nutritional intervention promoting the Mediterranean food pattern were accompanied by beneficial effects in circulating ox-LDL concentrations in healthy women.
authors.affiliation: Institute of Nutraceuticals and Functional Foods, Laval University, Québec, QC, Canada.
authors.forename: Annie
authors.initials: A
authors.lastname: Lapointe
authors.forename: Julie
authors.initials: J
authors.lastname: Goulet
authors.forename: Charles
authors.initials: C
authors.lastname: Couillard
authors.forename: Benoît
authors.initials: B
authors.lastname: Lamarche
authors.forename: Simone
authors.initials: S
authors.lastname: Lemieux
mesh_terms: D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D015930:Diet Records; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005638:Fruit; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D019083:Mediterranean Region; D008875:Middle Aged; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D011792:Quebec; D012016:Reference Values; D014505:Urban Population; D014675:Vegetables
chemical_list: D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein