Role of PAT proteins in lipid metabolism.
One of the central reactions in bodily energy metabolism is lipolysis in adipocytes, the reaction that governs the release of stored fatty acids from the adipocyte triacylglycerol pool, which constitutes the major energy reserve in animals. These fatty acids are then transported by serum albumin to various tissues to supply their energy requirements. This reaction was previously thought to result from phosphorylation and activation of hormone-sensitive lipase by protein kinase A (PKA) but is now known to be governed by a translocation of the lipase from the cytosol to the surface of the intracellular lipid droplet that houses the reservoir of TAG. This droplet is coated with perilipin A, which is also phosphorylated by PKA in response to lipolytic stimuli, and phosphorylation of perilipin A is essential for HSL translocation and stimulated lipolysis.
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NIDDK, National Institutes of Health, Building 50, Room 3140, Bethesda, MD 20896-8028, USA. deanl@intra.niddk.nih.gov
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D016475:3T3 Cells; D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D050356:Lipid Metabolism; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D000070778:Perilipin-1; D000070780:Perilipin-2; D000070796:Perilipin-3; D010750:Phosphoproteins / Q000235:genetics / Q000502:physiology*; D011257:Pregnancy Proteins / Q000502:physiology*; D002787:Sterol Esterase / Q000378:metabolism; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C038196:PLIN3 protein, human; D000070778:Perilipin-1; D000070780:Perilipin-2; D000070796:Perilipin-3; D010750:Phosphoproteins; D011257:Pregnancy Proteins; D033921:Vesicular Transport Proteins; D017868:Cyclic AMP-Dependent Protein Kinases; D002787:Sterol Esterase