title: Performance of coincidence imaging with long-lived positron emitters as an alternative to dedicated PET and SPECT.
abstract: An important application of quantitative imaging in nuclear medicine is the estimation of absorbed doses in radionuclide therapy. Depending on the radionuclide used for therapy, quantitative imaging of the kinetics of the therapeutic radiopharmaceutical could be done using planar imaging, SPECT or PET. Since many nuclear medicine departments have a gamma camera system that is also suitable for coincidence imaging, the performance of these systems with respect to quantitative imaging of PET isotopes that could be of use in radionuclide dosimetry is of interest. We investigated the performance of a gamma camera with coincidence imaging capabilities with 99mTc, 111In, 18F and 76Br and a dedicated PET system with 18F and 76Br, using a single standard set of phantom measurements. Here, 76Br was taken as a typical example of prompt gamma-emitting PET isotopes that are applicable in radionuclide therapy dosimetry such as 86Y and 124I. Image quality measurements show comparable image contrasts for 76Br coincidence imaging and 111In SPECT. Although the spatial resolution of coincidence imaging is better than single photon imaging, the contrast obtained with 76Br is not better than that with 99mTc or 111In because of the prompt gamma involved. Additional improvements are necessary to allow for quantitative coincidence imaging of long-lived, prompt gamma producing positron emitters.
authors.affiliation: Department of Hospital Physics, Uppsala University Hospital, 751 85 Uppsala, Sweden. mattias.sandstrom@akademiska.se
authors.forename: Mattias
authors.initials: M
authors.lastname: Sandström
authors.forename: Vladimir
authors.initials: V
authors.lastname: Tolmachev
authors.forename: Kalevi
authors.initials: K
authors.lastname: Kairemo
authors.forename: Hans
authors.initials: H
authors.lastname: Lundqvist
authors.forename: Mark
authors.initials: M
authors.lastname: Lubberink
mesh_terms: D000465:Algorithms; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods*; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods; D011868:Radioisotopes; D011877:Radionuclide Imaging / Q000295:instrumentation / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals