Neuroimaging and personality disorders.
Within the past several years, neuroimaging research on personality disorders has begun to develop. Personality disorders can be thought of as trait-like dysfunctional patterns in cognitive, affective, impulse control, and interpersonal domains. These domains of dysfunction have been linked to specific neural circuits. Developments in brain imaging techniques have allowed researchers to examine the neural integrity of these circuits in personality-disordered individuals. This article reviews the neuroimaging literature on borderline personality disorder, antisocial personality disorder (including psychopathy) and schizotypal personality disorder. Functional and structural studies provide support for dysfunction in fronto-limbic circuits in borderline and antisocial personality disorder, whereas temporal lobe and basal striatal-thalamic compromise is evident in schizotypal personality disorder.
McCloskey
Michael S
MS
Department of Psychiatry, MC #3077, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA. mmcclosk@yoda.bsd.uchicago.edu
Phan
K Luan
KL
Coccaro
Emil F
EF
D000987:Antisocial Personality Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001883:Borderline Personality Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D011859:Radiography; D012569:Schizotypal Personality Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology*; D015899:Tomography, Emission-Computed, Single-Photon
Trends Cogn Sci. 1999 Jan;3(1):11-21
10234222
Schizophr Res. 2002 Mar 1;54(1-2):141-50
11853988
Crim Behav Ment Health. 2004;14(1):39-54
14654860
Schizophr Res. 1997 Feb 28;23(3):189-96
9075296
Psychiatry Res. 2000 Apr 10;93(3):237-46
10760382
Schizophr Res. 2004 Dec 1;71(2-3):249-62
15474896
J Neuropsychiatry Clin Neurosci. 2001 Fall;13(4):511-4
11748321
Behav Brain Res. 2000 May;109(2):177-86
10762687
Psychiatry Res. 1995 Jul 28;57(2):109-18
7480378
Arch Gen Psychiatry. 1989 Jul;46(7):587-99
2735812
Schizophr Res. 1997 Oct 17;27(1):21-8
9373891
Arch Gen Psychiatry. 2001 Feb;58(2):133-40
11177115
Neuropsychobiology. 2000;42(4):192-201
11096335
Biol Psychiatry. 2003 Jul 15;54(2):152-62
12873805
J Pers Disord. 1999 Winter;13(4):329-44
10633314
Neuroimage. 2003 Sep;20(1):385-92
14527598
Biol Psychiatry. 2000 Mar 15;47(6):540-7
10715360
Biol Psychiatry. 1997 Jul 15;42(2):96-103
9209726
Aust N Z J Psychiatry. 1999 Apr;33(2):187-96
10336216
Curr Psychiatry Rep. 2000 Feb;2(1):62-6
11122934
Schizophr Res. 1997 Oct 17;27(1):45-53
9373894
Am J Psychiatry. 2002 Jul;159(7):1190-7
12091198
Harv Rev Psychiatry. 2002 Jan-Feb;10(1):1-15
11751641
Schizophr Res. 1999 May 25;37(2):123-32
10374648
Biol Psychiatry. 2004 May 15;55(10):1001-6
15121484
Am J Psychiatry. 1998 Apr;155(4):509-15
9545997
Biol Psychiatry. 1999 Jun 1;45(11):1393-402
10356620
Psychiatry Res. 2004 Apr 30;130(3):213-25
15135156
J Affect Disord. 1998 Sep;50(2-3):235-43
9858082
J Psychiatr Res. 2003 Mar-Apr;37(2):109-15
12842164
J Psychiatr Res. 1997 Sep-Oct;31(5):531-41
9368195
Br J Psychiatry. 2003 Jan;182:5-7
12509310
Biol Psychiatry. 2002 Jun 15;51(12):951-63
12062878
Arch Gen Psychiatry. 2001 Sep;58(9):877-84
11545672
Am J Psychiatry. 2003 Dec;160(12):2198-201
14638590
Biol Psychiatry. 2001 Aug 15;50(4):292-8
11522264
Arch Gen Psychiatry. 1994 Dec;51(12):955-62
7979884
Psychiatry Res. 1994 Dec;55(4):237-45
7701037
Psychiatry Res. 2003 Apr 1;122(3):193-8
12694893
Psychiatry Res. 2003 Jul 30;123(3):153-63
12928103
Curr Psychiatry Rep. 2000 Oct;2(5):446-51
11122995
Biol Psychiatry. 2003 Jul 15;54(2):163-71
12873806
Am J Psychiatry. 2002 Sep;159(9):1521-7
12202272
Schizophr Res. 2001 Mar 30;48(2-3):187-99
11295372
Psychiatry Res. 2004 Jul 30;131(2):125-33
15313519
Neuropsychopharmacology. 1999 May;20(5):413-23
10192822
Am J Psychiatry. 1991 Dec;148(12):1647-58
1957926
Arch Gen Psychiatry. 2000 Dec;57(12):1115-22
11115325
Biol Psychiatry. 2004 Jan 15;55(2):185-91
14732599
Am J Psychiatry. 1999 Aug;156(8):1190-9
10450259
Curr Opin Neurobiol. 2004 Apr;14(2):254-8
15082333
Arch Gen Psychiatry. 2000 Feb;57(2):119-27; discussion 128-9
10665614
Annu Rev Neurosci. 2001;24:167-202
11283309
Biol Psychiatry. 2004 Apr 1;55(7):759-65
15039006
Psychol Med. 2002 Apr;32(3):417-27
11989987
Am J Psychiatry. 2001 Nov;158(11):1783-93
11691682
Eur Arch Psychiatry Clin Neurosci. 2002 Dec;252(6):268-77
12563535
Biol Psychiatry. 2001 Nov 1;50(9):677-84
11704074
Neuroimage. 2002 Jun;16(2):331-48
12030820
Biol Psychiatry. 2004 Jan 15;55(2):177-84
14732598
Psychiatry Res. 2002 Jun 15;114(2):95-102
12036509
Am J Psychiatry. 2000 Jan;157(1):48-54
10618012
J Anxiety Disord. 2005;19(1):1-28
15488365
Schizophr Res. 2000 May 5;42(3):193-208
10785578
Psychol Assess. 2002 Mar;14(1):27-38
11911046
Schizophr Res. 2003 Nov 1;64(1):35-9
14511799
Arch Gen Psychiatry. 2001 Jun;58(6):590-6
11386989
Psychol Med. 2002 Nov;32(8):1395-405
12455938
Psychiatry Res. 2004 Apr 30;130(3):297-312
15209063
Behav Brain Res. 2001 Jan 29;118(2):187-93
11164516
Arch Gen Psychiatry. 2003 Nov;60(11):1134-42
14609889
Biol Psychiatry. 2003 Dec 1;54(11):1284-93
14643096