New naphthylcombretastatins. Modifications on the ethylene bridge.
Compounds with three aromatic systems, carrying a 2-naphthalene and a 3,4,5-trimethoxyphenyl moieties bonded to five-membered, six-membered or fused heterocycles display potent cytotoxic effect and inhibition of tubulin polymerization, in agreement with their structural similarity to combretastatins and their heterocyclic analogues.
Sánchez Maya
Ana B
AB
Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
Pérez-Melero
Concepción
C
Salvador
Nélida
N
Peláez
Rafael
R
Caballero
Esther
E
Medarde
Manuel
M
D000818:Animals; D001632:Bibenzyls / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002417:Cattle; D005030:Ethylenes / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000378:metabolism
D001632:Bibenzyls; D005030:Ethylenes; D009281:Naphthalenes; D013267:Stilbenes; D014404:Tubulin; C031721:naphthalene; C040105:combretastatin; C036216:ethylene