Molecular cardiovascular imaging.
Imaging with radionuclides has historically played an important role in detection of cardiovascular disease as well as in risk stratification and prognostication. With the growth of molecular biology have come new therapeutic interventions and the requirement for new diagnostic imaging approaches. Noninvasive targeted radiotracer-based strategies require the development of new instrumentation to meet these needs. This progress has been made possible with the availability of many technologic advances, which include dedicated micro single-photon emission computed tomography (SPECT) and micro positron emission tomography (PET) hybrid systems for small animal imaging. This review is a brief overview on the subject of molecular imaging. Basic concepts of molecular imaging are reviewed, followed by description of current technologic advances, and current applications to evaluate ischemic heart disease and potential therapeutic intervention. The emphasis is on the use of both SPECT and PET radiotracers, although other imaging modalities are also briefly discussed.
Dobrucki
Lawrence W
LW
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, PO Box 208017, 3FMP, New Haven, CT 06520-8017, USA.
Sinusas
Albert J
AJ
D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use; D000818:Animals; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging*; D004195:Disease Models, Animal; D004285:Dogs; D018014:Gene Transfer Techniques; D017930:Genes, Reporter; D015316:Genetic Therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000628:therapy*; D049268:Positron-Emission Tomography; D011817:Rabbits; D051381:Rats; D012680:Sensitivity and Specificity; D013552:Swine; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D020257:Ventricular Remodeling
D043925:Angiogenesis Inducing Agents
Cancer Res. 2003 Sep 15;63(18):5838-43
14522907
J Magn Reson Imaging. 2002 Oct;16(4):352-61
12353251
J Clin Invest. 2004 Jun;113(12):1684-91
15199403
J Nucl Cardiol. 2004 Jul-Aug;11(4):491-505
15295418
Circulation. 2003 Nov 4;108(18):2270-4
14557370
Circulation. 2003 Jan 21;107(2):326-32
12538436
Circulation. 2003 Jan 28;107(3):455-60
12551871
Nat Med. 1998 May;4(5):623-6
9585240
J Cell Biochem. 2003 Oct 15;90(3):443-53
14523978
Mol Imaging. 2002 Oct;1(4):344-53
12926230
J Nucl Cardiol. 2004 Sep-Oct;11(5):617-33
15472646
IEEE Trans Med Imaging. 2004 Jul;23(7):896-902
15250642
Phys Med Biol. 2001 Nov;46(11):2899-910
11720354
Semin Nucl Med. 2000 Oct;30(4):281-98
11105929
J Nucl Med. 1999 Jul;40(7):1164-75
10405138
J Nucl Med. 2001 May;42(5 Suppl):1S-93S
11483694
Phys Med Biol. 2001 Jul;46(7):1845-62
11474929
Circulation. 2003 Jul 8;108(1):97-103
12821549
Eur J Nucl Med Mol Imaging. 2003 May;30(5):737-47
12536244
Mol Imaging. 2004 Apr;3(2):125-34
15296677
Circulation. 2002 Jul 9;106(2):180-3
12105155
Circulation. 2004 Aug 10;110(6):685-91
15302807
AORN J. 1995 Sep;62(3):343-50, 353-5; quiz 356-8, 361-2
8534053
Phys Med Biol. 2004 Jun 21;49(12 ):2527-45
15272672