Evaluation of some pyrazoloquinolines as inhibitors of herpes simplex virus type 1 replication.
Three structurally related aminopyrazoloquinoline derivatives were evaluated for their antiviral activity against Herpes Simplex virus type 1. These compounds were examined for their in vitro antiviral activity by two different bioassays, namely; crystal violet staining and tetrazolium dye (MTS) measurement. The antiviral role of these compounds was confirmed by enumerating the infectious particles with plaque assay. The acute toxicity values of the biologically active compounds were determined prior to their screening as antiviral agents.
Bekhit
Adnan A
AA
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.
El-Sayed
Ola A
OA
Aboul-Enein
Hassan Y
HY
Siddiqui
Yunus M
YM
Al-Ahdal
Mohammed N
MN
D000818:Animals; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D014779:Virus Replication / Q000187:drug effects*
D011804:Quinolines