title: Early effects of transplatin on oncogene activation in vivo.
abstract: The aim of the study was to investigate the early effect of Transplatin (the stereo-isomer of Cisplatin) on oncogenes in inbred CBA/Ca mice. Cisplatin is commonly used for the treatment of squamous cell carcinomas of the head and neck. Cisplatin has a strong oncogene activation effect compared to the structural analogue Transplatin. Body weight equivalent amounts of a human dose of Transplatin were administered intra-peritoneally to 6- to 8-week-old, inbred, female CBA/Ca mice. Twenty-four, 48 and 72 hours after the treatment, RNA was isolated from the target organs and the expressions of c-myc, Ha-ras and p53 genes were examined. Investigation of early changes showed no significant overexpression compared to Cisplatin, which had a significant effect on oncogene expression in the "short-term" in vivo test system.
authors.affiliation: Department of Public Health, Faculty of Medicine, University of Pécs, Hungary. arpadnemeth@freemail.hu
authors.forename: A
authors.initials: A
authors.lastname: Németh
authors.forename: E
authors.initials: E
authors.lastname: Nádasi
authors.forename: A
authors.initials: A
authors.lastname: Beró
authors.forename: L
authors.initials: L
authors.lastname: Olasz
authors.forename: A
authors.initials: A
authors.lastname: Ember
authors.forename: A
authors.initials: A
authors.lastname: Kvarda
authors.forename: L
authors.initials: L
authors.lastname: Bujdosó
authors.forename: I
authors.initials: I
authors.lastname: Arany
authors.forename: A
authors.initials: A
authors.lastname: Csejtei
authors.forename: Zs
authors.initials: Z
authors.lastname: Faluhelyi
authors.forename: I
authors.initials: I
authors.lastname: Ember
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D016259:Genes, myc / Q000187:drug effects* / Q000235:genetics; D016158:Genes, p53 / Q000187:drug effects* / Q000235:genetics; D011905:Genes, ras / Q000187:drug effects* / Q000235:genetics; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000502:physiology; D008168:Lung / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects / Q000502:physiology
chemical_list: C034697:transplatin; D002945:Cisplatin