An antibacterial biphenyl derivative from Garcinia bancana MIQ.
From the methanol extract of the twigs and leaves of Garcinia bancana MIQ., one new biphenyl derivative (1), was isolated and characterized along with nine known compounds; garcinol, isogarcinol, (-)-mellein, 8-hydroxy-6-methoxy-3-n-pentylisocoumarin, blumenol C O-beta-D-glucoside, quercetin 3-O-alpha-L-rhamnoside, kaemferol 3-O-alpha-L-rhamnoside, lupeol and stigmasterol. Their structures were determined by analysis of 1D and 2D NMR data and comparison of spectral data and physical data with those previously reported. The antibacterial activity against methicillin-resistant Staphylococcus aureus was evaluated. Garcinol showed the lowest minimum inhibition concentration (MIC) at 16 microg/ml while compound 1 exhibited weaker activity with MIC value of 64 microg/ml.
Rukachaisirikul
Vatcharin
V
Department of Chemistry, Faculty of Science, Prince of Songkla University, Thailand. vatcharin.r@psu.ac.th
Naklue
Wanpen
W
Sukpondma
Yaowapa
Y
Phongpaichit
Souwalak
S
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029760:Garcinia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D012996:Solutions / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001713:Biphenyl Compounds; D010936:Plant Extracts; D012996:Solutions; D000432:Methanol