Sympathoadrenal system under conditions of increased left and right ventricular afterload.
Adrenergic plexuses in the myocardium and adrenal medulla were studied histochemically under conditions of increased left or right ventricular afterload. Under conditions of high afterload not accompanied by heart failure the density of sympathetic myocardial innervation remained unchanged in the loaded ventricle, but increased in the intact ventricle. Comparison of the state of the sympathoadrenal system under conditions of increased afterload complicated or uncomplicated by heart failure revealed common prognostically unfavorable changes: sharp decrease in the density of adrenergic nerve plexuses in the ventricular myocardium and activation of adrenal chromaffin cells.
Tverskaya
M S
MS
Russian State Medical University, Moscow. mtver@rsmu.ru
Mishnev
O D
OD
Karpova
V V
VV
Izmailova
N S
NS
Chumakova
M A
MA
Virganskii
A O
AO
Kadyrova
M Kh
MKh
Abdulkerimova
N Z
NZ
Bobrova
N A
NA
D000311:Adrenal Glands / Q000294:innervation*; D000818:Animals; D004195:Disease Models, Animal; D006168:Guinea Pigs; D013564:Sympathetic Nervous System / Q000503:physiopathology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology*