The role of pH monitoring in extraesophageal gastroesophageal reflux disease.
Gastroesophageal reflux disease (GERD) is linked to several extraesophageal disease states including laryngitis, asthma, chronic cough, and noncardiac chest pain (NCCP). Although 24-hour pH monitoring is considered the "gold standard" in the diagnosis of typical GERD, it is also increasingly used in establishing the diagnosis of GERD in patients with extraesophageal symptoms. The clinical utility of pH monitoring in this patient population, however, remains controversial. In this article, the authors examine the role of pH monitoring in laryngitis, asthma, chronic cough, and NCCP.
Ahmed
Tasneem
T
Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Vaezi
Michael F
MF
D001249:Asthma / Q000175:diagnosis* / Q000453:epidemiology; D002908:Chronic Disease; D003371:Cough / Q000175:diagnosis* / Q000453:epidemiology; D003937:Diagnosis, Differential; D005745:Gastric Acidity Determination / Q000295:instrumentation; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007827:Laryngitis / Q000175:diagnosis* / Q000453:epidemiology; D007828:Laryngoscopy / Q000379:methods; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*; D015995:Prevalence; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index