Hemorrhage control in the battlefield: role of new hemostatic agents.
Uncontrolled hemorrhage is the leading cause of preventable combat-related deaths. The vast majority of these deaths occur in the field before the injured can be transported to a treatment facility. Early control of hemorrhage remains the most effective strategy for treating combat casualties. A number of hemostatic agents have recently been deployed to the warfront that can be used to arrest bleeding before surgical control of the source. The purpose of this article is to summarize the background information regarding these hemostatic agents, indications and rationale for their use, and characteristics of these products that may impact effectiveness.
Alam
Hasan B
HB
Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. halam@usuhs.mil
Burris
David
D
DaCorta
Joseph A
JA
Rhee
Peter
P
D000117:Acetylglucosamine / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D006470:Hemorrhage / Q000188:drug therapy* / Q000517:prevention & control; D006490:Hemostatics / Q000145:classification / Q000627:therapeutic use*; D006801:Humans; D008887:Military Medicine / Q000379:methods*; D014857:Warfare; D014947:Wounds and Injuries / Q000503:physiopathology*; D017641:Zeolites / Q000627:therapeutic use
D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; C113831:poly-N-acetyl glucosamine; D017641:Zeolites; D000117:Acetylglucosamine