[Circulating progenitors contribute to angiogenesis, vascular repair, and lesion formation].
Atherosclerosis is responsible for more than half of all deaths in western countries. Numerous studies have reported that exuberant accumulation of smooth muscle cells plays a principal role in the pathogenesis of vascular diseases. It has been assumed that smooth muscle cells derived from the adjacent medial layer migrate, proliferate and synthesize extracellular matrix. Although much effort has been devoted, targeting migration and proliferation of medial smooth muscle cells, no effective therapy to prevent occlusive vascular remodeling has been established. Recently, we reported that bone marrow cells substantially contribute to the pathogenesis of vascular diseases, in models of post-angioplasty restenosis, graft vasculopathy and hyperlipidemia-induced atherosclerosis. It was suggested that bone marrow cells may have the potential to give rise to vascular progenitor cells that home in the damaged vessels and differentiate into smooth muscle cells or endothelial cells, thereby contributing to vascular repair, remodeling, and lesion formation. This article overviews recent findings on circulating vascular precursors and describes potential therapeutic strategies for vascular diseases, targeting mobilization, homing, differentiation and proliferation of circulating progenitor cells.
Sata
Masataka
M
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-8655.
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D001808:Blood Vessels / Q000502:physiology*; D001854:Bone Marrow Cells / Q000502:physiology; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D018919:Neovascularization, Physiologic; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*