Emi1 and Erp1: who can stop these eggs?
Vertebrate eggs prevent parthenogenetic development by producing cytostatic factor (CSF), which blocks exit from metaphase of meiosis II until fertilization. CSF was never purified but recently suspected to inhibit the anaphase-promoting complex (APC), an ubiquitin ligase required for entry into anaphase. In a recent paper in Genes & Development, Schmidt et al. describe the Xenopus APC inhibitor Erp1, which seems to be the best candidate yet for the downstream effector of CSF activity.
Zachariae
Wolfgang
W
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
D000705:Anaphase / Q000502:physiology; D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002118:Calcium / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism*; D044783:F-Box Proteins / Q000378:metabolism*; D005260:Female; D005306:Fertilization / Q000502:physiology; D008540:Meiosis / Q000502:physiology*; D009865:Oocytes / Q000166:cytology* / Q000378:metabolism; D017231:Proto-Oncogene Proteins c-mos / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*; D029867:Xenopus Proteins / Q000378:metabolism*; D014982:Xenopus laevis / Q000378:metabolism
D018797:Cell Cycle Proteins; D044783:F-Box Proteins; C498166:FBXO43 protein, Xenopus; C429107:FBXO5 protein, Xenopus; D029867:Xenopus Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; C495329:Mos protein, Xenopus; D017231:Proto-Oncogene Proteins c-mos; D002118:Calcium