Primary HIV-1 Infection: Diagnosis, Pathogenesis, and Treatment.
Primary HIV-1 infection represents the time when the virus is first disseminating throughout the body and induces host immune responses. Diagnosing this stage of disease requires an understanding of who is at risk, the clinical manifestations of primary infection, and how the diagnosis is made. Identifying these individuals allows for counseling to prevent further transmission to others and the potential benefits associated with early antiretroviral therapy. Moreover, studying these individuals provides important insight into the biology of HIV-1 transmission and immunopathogenesis.
Soogoor
Malini
M
Division of HIV Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center; David Geffen School of Medicine at UCLA, 1124 West Carson Street, N-24, Torrance, CA 90502, USA. edaar@labiomed.org.
Daar
Eric S
ES
AIDS. 2000 Oct 20;14(15):2406-7
11089632
Nature. 2000 Sep 28;407(6803):523-6
11029005
J Acquir Immune Defic Syndr. 2003 Jan 1;32(1):94-103
12514420
N Engl J Med. 1997 Oct 30;337(18):1267-74
9345075
AIDS. 2004 Jun 18;18(9):1311-20
15362664
Clin Infect Dis. 2003 Jul 1;37(1):113-28
12830416
J Clin Invest. 2002 Mar;109(5):681-8
11877476
JAMA. 2004 Jul 14;292(2):251-65
15249575
Arch Intern Med. 2003 Sep 22;163(17):2097-100
14504125
J Clin Immunol. 2004 Mar;24(2):135-44
15024180
Ann Intern Med. 1998 May 15;128(10):827-9
9599194
J Infect Dis. 2004 Jun 15;189(12):2174-80
15181563
AIDS. 2003 Oct 17;17(15):2269-71
14523289
AIDS. 2004 Aug 20;18(12):1683-9
15280779
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4144-9
12644702
JAMA. 2002 Jul 10;288(2):216-21
12095386
J Immunol. 2003 Apr 1;170(7):3906-14
12646660
Lancet Infect Dis. 2003 Jan;3(1):10-1
12505024
J Infect Dis. 2004 May 15;189(10):1793-801
15122515
AIDS. 2004 Mar 26;18(5):709-18
15075505
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15006-10
14657379
AIDS. 2003 Sep 5;17(13):1871-9
12960819
N Engl J Med. 2002 Aug 8;347(6):385-94
12167680
Ann Intern Med. 2001 Jan 2;134(1):25-9
11187417
HIV Med. 2004 Jan;5(1):26-9
14731166
J Virol. 2003 Dec;77(23):12921-6
14610215
J Acquir Immune Defic Syndr. 1999 Jun 1;21(2):99-106
10360800
Am J Public Health. 2001 Jul;91(7):1060-8
11441732
J Infect Dis. 2000 Sep;182(3):950-4
10950796
JAMA. 2004 Jul 14;292(2):224-36
15249572
J Infect Dis. 2004 Aug 15;190(4):713-21
15272399
AIDS. 2004 Mar 26;18(5):749-55
15075509
Science. 1997 Nov 21;278(5342):1447-50
9367954
AIDS. 2002 Jan 25;16(2):189-95
11807302
N Engl J Med. 1999 May 27;340(21):1683-4
10348681
J Virol. 2001 Aug;75(15):6953-61
11435575
AIDS. 1995 Jun;9(6):597-604
7662199
HIV Med. 2004 Sep;5(5):326-33
15369507
N Engl J Med. 1995 Aug 17;333(7):408-13
7616989
Curr Top Microbiol Immunol. 2003;276:31-54
12797442
J Infect Dis. 2002 Sep 1;186(5):634-43
12195350
J Virol. 1994 Jul;68(7):4650-5
8207839
AIDS. 2003 May 2;17(7):1086-9
12700462