Characterization of Opr deficiency in mouse brain: subtle defects in dorsomedial telencephalon and medioventral forebrain.
Opr/Zic5 is a zinc-finger gene belonging to, and unique in, the opa/Zic family. Its expression is found in the anterior epiblast and anterior neuroectoderm during gastrulation and early neurulation. Later, we found the expression characteristic in the dorsomedial parts of forebrain and midbrain. However, no defects were apparent in embryonic day 10.5 Opr null mutants, and subtle defects were later found in medial pallium and ventral structures of forebrain, suggesting the compensation of Opr deficiency by its cognate(s).
Furushima
Kenryo
K
Laboratory for Animal Resources and Genetic Engineering, Center for Developmental Biology (CDB), RIKEN Kobe, Kobe, Japan.
Murata
Takuya
T
Kiyonari
Hiroshi
H
Aizawa
Shinichi
S
D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics*; D004268:DNA-Binding Proteins; D017353:Gene Deletion; D051379:Mice; D008817:Mice, Mutant Strains; D013687:Telencephalon / Q000196:embryology* / Q000473:pathology; D014157:Transcription Factors
D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D014157:Transcription Factors; C418623:Zic5 protein, mouse