Healing sound: the use of ultrasound in drug delivery and other therapeutic applications.
Ultrasound, which is routinely used for diagnostic imaging applications, is now being adopted in various drug delivery and other therapeutic applications. Ultrasound has been shown to facilitate the delivery of drugs across the skin, promote gene therapy to targeted tissues, deliver chemotherapeutic drugs into tumours and deliver thrombolytic drugs into blood clots. In addition, ultrasound has also been shown to facilitate the healing of wounds and bone fractures. This article reviews the principles and current status of ultrasound-based treatments.
Mitragotri
Samir
S
Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA. samir@engineering.ucsb.edu
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000925:Anticoagulants / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000008:administration & dosage*; D013927:Thrombosis / Q000628:therapy; D014464:Ultrasonic Therapy / Q000379:methods*
D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D007004:Hypoglycemic Agents; D007328:Insulin; D006854:Hydrocortisone