title: Biosynthetic origin of the carbon skeleton and nitrogen atom of pamamycin-607, a nitrogen-containing polyketide.
abstract: The biosynthesis of pamamycin-607 (PM-607), a sixteen-membered macrodiolide compound, was studied with 13C- and 15N-labeled precursor units in Streptomyces alboniger. Feeding experiments with 13C-labeled acetate or propionate indicate that the carbon skeleton of PM-607 was derived from six acetate, four propionate and three succinate units. MS analyses of 15N-labeled PM-607 suggest that the nitrogen atom in PM-607 was derived from the alpha-amino group of an amino acid.
authors.affiliation: Department of Plant Protection, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Komatsu
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kozone
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaide
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Abe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Natsume
mesh_terms: D002247:Carbon Isotopes; D018942:Macrolides / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure; D009587:Nitrogen Isotopes; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D002247:Carbon Isotopes; D018942:Macrolides; D009587:Nitrogen Isotopes; C470905:pamamycin-607