[Corticosteroid-induced osteoporosis].
Osteoporosis and fractures are the frequent consequences of corticosteroid therapy. Cancellous bone is primarily affected with a decrease of bone formation and an increase of bone resorption. Prevention of corticosteroid-induced osteoporosis is based upon general measures such as calcium and vitamin D supplementation, adequate protein intake, regular physical exercise, and upon specific therapies like those used in primary osteoporosis. Biphosphonates, which are potent bone resorption inhibitors, have been shown to increase bone mineral density and to decrease vertebral fracture rate. Therefore, they appear to be a first choice in the prevention of corticosteroid-induced osteoporosis.
Trombetti
Andrea
A
Service des maladies osseuses (Centre collaborateur de l'OMS pour la prévention de l'ostéoporose), département de réhabilitation et gériatrie, hôpitaux universitaires de Genève, 1211 Genève 14, Suisse. Andrea.Trombetti@hcuge.ch
Pennisi
Pietra
P
Rizzoli
René
R
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced* / Q000517:prevention & control
D000305:Adrenal Cortex Hormones