In vitro screening of some Strychnos species for antiplasmodial activity.
The antiplasmodial activity of crude extracts of 19 species of Strychnos (Loganiaceae) was assessed in vitro against a chloroquine-susceptible strain of Plasmodium falciparum. For each species, ethyl acetate (EtOAc) extracts were analysed and, for the most active species, methanolic (MeOH) extracts were also tested. Among them, Strychnos variabilis De Wild. seemed to be very promising (inhibitory concentration 50% (IC50) < 5 microg/ml) whereas two other species, Strychnos gossweileri Exell and Strychnos mellodora S. Moore, could be interesting (IC50 < 15 microg/ml) in further antimalarial studies.
Philippe
Geneviève
G
University of Liège, Natural and Synthetic Drugs Research Center, Laboratory of Pharmacognosy, B36, Avenue de l'Hôpital 1, 4000 Liège, Belgium.
Angenot
Luc
L
De Mol
Patrick
P
Goffin
Eric
E
Hayette
Marie-Pierre
MP
Tits
Monique
M
Frédérich
Michel
M
D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000502:physiology; D031451:Strychnos
D000981:Antiprotozoal Agents; D010936:Plant Extracts