Thiazolidinediones and cardiovascular disease.
Thiazolidinediones hold promise for reducing cardiovascular events and human atherosclerosis. Similar to statins and angiotensin-converting enzyme inhibitors, peroxisome proliferator activated receptor gamma (PPARgamma) exerts anti-inflammatory and antiatherosclerotic actions in the vessel wall. A number of clinical trials in subjects with or without diabetes have shown that thiazolidinedione therapy can reduce in-stent restenosis and delay progression of atherosclerosis measured by carotid artery ultrasound. PPARgamma directly promotes expression of ATP-binding cassette transporter G1, mediating cellular cholesterol efflux to high-density lipoproteins from macrophages, which may further explain the potential cardiovascular benefit of this class. Whether the benefits observed in animal models will translate in clinical practice is being evaluated in several large, randomized controlled trials.
Chilton
Robert
R
Department of Veterans Affairs, Audie L. Murphy Veterans Hospital, 7400 Merton Minter, San Antonio, TX 78284, USA. chilton@uthscsa.edu
Chiquette
Elaine
E
D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D004247:DNA / Q000235:genetics; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D047495:PPAR gamma / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D016032:Randomized Controlled Trials as Topic; D045162:Thiazolidinediones / Q000627:therapeutic use*; D016896:Treatment Outcome; D014463:Ultrasonography
D047495:PPAR gamma; D045162:Thiazolidinediones; D004247:DNA
J Clin Endocrinol Metab. 2001 Jul;86(7):3452-6
11443224
Control Clin Trials. 1987 Dec;8(4):356-87
3327654
Circulation. 2000 Jul 18;102(3):313-8
10899095
Circulation. 2000 Jan 25;101(3):235-8
10645917
Arterioscler Thromb. 1993 Dec;13(12 ):1829-36
8241104
Circulation. 2000 Jul 4;102(1):42-7
10880413
Ann N Y Acad Sci. 2000 Apr;905:97-109
10818446
Drugs. 2002;62(10 ):1463-80
12093315
Circulation. 2000 May 23;101(20):2411-7
10821819
N Engl J Med. 1999 Jan 7;340(1):14-22
9878640
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9774-9
15210959
Diabetes Care. 2002 Oct;25(10):1737-43
12351470
Circulation. 1998 May 26;97(20):2007-11
9610529
Am J Cardiol. 2001 Oct 18;88(8A):10K-15K
11694213
Am Heart J. 2004 May;147(5):e23
15131558
Diabetologia. 2000 Sep;43(9):1165-9
11043863
Circulation. 1999 Sep 14;100(11):1148-50
10484532
Circulation. 1994 Oct;90(4):1679-87
7734010
Arterioscler Thromb Vasc Biol. 2004 May;24(5):930-4
15001452
Diabetes Care. 2004 Nov;27(11):2654-60
15505001
Circulation. 2000 Oct 17;102(16):1970-6
11034947
J Clin Invest. 1997 Jun 15;99(12):2814-6
9185501
Circulation. 2000 Jun 13;101(23):2682-9
10851204
Circulation. 1995 Oct 1;92 (7):1758-64
7671358
N Engl J Med. 2002 Nov 14;347(20):1557-65
12432042
Eur J Pharmacol. 2003 Apr 18;466(3):225-34
12694805
J Clin Invest. 2004 Dec;114(11):1564-76
15578089
Arterioscler Thromb. 1994 Dec;14 (12 ):1885-91
7981175
Circulation. 1997 Sep 2;96(5):1432-7
9315528
J Biol Chem. 1998 Oct 2;273(40):25573-80
9748221
Stroke. 1997 Feb;28(2):348-53
9040688
J Intern Med. 1991 Mar;229(3):225-31
2007840
Nature. 1998 Jan 1;391(6662):82-6
9422509
Circulation. 1998 May 12;97(18):1784-90
9603532
Circulation. 2000 Mar 21;101(11):1311-8
10725292
Am Heart J. 2003 Aug;146(2):E5
12891212
Am J Pathol. 1998 Jul;153(1):17-23
9665460
Arterioscler Thromb Vasc Biol. 2003 Dec;23(12):2203-8
12958047
J Clin Endocrinol Metab. 2001 Jul;86(7):3250-6
11443197
Circ Res. 1998 Nov 30;83(11):1097-103
9831704
Am J Cardiol. 1995 Sep 28;76(9):54C-59C
7572688
Circ Res. 1999 Sep 3;85(5):394-402
10473669
Inflamm Res. 2000 Oct;49(10):497-505
11089900
Nature. 1998 Jan 1;391(6662):79-82
9422508
J Clin Endocrinol Metab. 2001 Mar;86(3):1306-12
11238525
Circulation. 2003 May 27;107(20):2548-50
12742988
J Leukoc Biol. 1999 Nov;66(5):733-9
10577502
J Biol Chem. 2000 Jul 21;275(29):22435-41
10801895
Circulation. 1999 Jun 22;99(24):3125-31
10377075
Circulation. 2002 Aug 6;106(6):679-84
12163427
J Clin Endocrinol Metab. 2004 Jun;89(6):2728-35
15181049
J Immunol. 2000 Feb 1;164(3):1364-71
10640751
Nat Med. 2001 Jan;7(1):41-7
11135614
Diabetes Care. 2004 Jul;27(7):1647-53
15220241
Diabetes. 2001 Oct;50(10):2384-9
11574423
Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):546-51
10073956
Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7614-9
9636198
Hypertension. 2002 Nov;40(5):687-93
12411463