Inducible metronidazole resistance and nim genes in clinical Bacteroides fragilis group isolates.
Nitroimidazole resistance (nim) genes were detected in 2% of 1,502 clinical Bacteroides fragilis group strains isolated from 19 European countries, and a novel nim gene was identified. High metronidazole resistance could be induced in nim-positive strains, which emphasizes the importance of acknowledging metronidazole resistance in the clinical setting.
Löfmark
Sonja
S
Department of Laboratory Medicine, Division of Clinical Bacteriology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Fang
Hong
H
Hedberg
Maria
M
Edlund
Charlotta
C
D001441:Bacteroides fragilis / Q000187:drug effects* / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D008795:Metronidazole
FEMS Microbiol Lett. 1999 Mar 1;172(1):79-83
10079531
J Antimicrob Chemother. 2003 Jun;51(6):1436-7
12746378
Antimicrob Agents Chemother. 1997 Jul;41(7):1495-9
9210672
J Antimicrob Chemother. 2004 Jul;54(1):109-16
15190033
Am J Surg. 1995 May;169(5A Suppl):2S-7S
7755163
Clin Infect Dis. 1997 Jan;24 Suppl 1:S110-20
8994790
J Antimicrob Chemother. 1993 Feb;31(2):201-10
8463167
J Bacteriol. 1996 Dec;178(23):6671-6
8955281
Microbiology. 1995 Apr;141 ( Pt 4):927-35
7773395
Antimicrob Agents Chemother. 1994 May;38(5):1047-51
8067736
J Bacteriol. 2001 Jun;183(11):3531-5
11344163
Anaerobe. 1996 Apr;2(2):59-69
16887551
J Clin Microbiol. 2004 Sep;42(9):4127-9
15364999
Plasmid. 1989 Mar;21(2):151-4
2740453
J Clin Microbiol. 2000 Sep;38(9):3209-13
10970359
Microbes Infect. 2003 Jan;5(1):19-26
12593969
Clin Infect Dis. 1996 Dec;23 Suppl 1:S36-43
8953105
Clin Infect Dis. 1994 May;18 Suppl 4:S297-304
8086579
Clin Microbiol Infect. 2003 Jun;9(6):475-88
12848722
Clin Microbiol Infect. 1999 Mar;5(3):166-169
11856242
Acta Biol Hung. 2001;52(2-3):271-80
11426861
Appl Environ Microbiol. 2001 Feb;67(2):561-8
11157217
J Antimicrob Chemother. 1999 Oct;44(4):580-1
10588328
J Clin Microbiol. 1996 Sep;34(9):2078-84
8862561