Long-distance retrograde neurotrophic signaling.
The retrograde communication of neurotrophic signals from axon terminals to neuron cell bodies is crucial for neuron survival and plasticity. Several mechanisms have been proposed in the past, but recent evidence strongly supports the hypothesis that the retrograde propagation of self-regenerating signaling organelles, derived from the endocytosis of activated neurotrophin-bound receptor tyrosine kinases, is the primary mechanism responsible for this long-distance communication.
Howe
Charles L
CL
Departments of Neuroscience and Neurology, Mayo Clinic College of Medicine, Guggenheim 442-C, 200 First Street SW, Rochester, MN 55905, USA. ngfv1@stanford.edu
Mobley
William C
WC
D000818:Animals; D002470:Cell Survival / Q000502:physiology; D011992:Endosomes / Q000502:physiology*; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D009474:Neurons / Q000166:cytology* / Q000201:enzymology / Q000502:physiology*; D012183:Retrograde Degeneration / Q000473:pathology; D015398:Signal Transduction / Q000502:physiology*
D009414:Nerve Growth Factors