title: Lipid-lowering therapy in patients with average cholesterol and high cardiovascular risk, insights from the Heart Protection Study.
abstract: Although the benefits of cholesterol-lowering with statins has been established for patients with high cholesterol levels as well as for patients with prior occlusive coronary heart disease, substantial uncertainty has existed about the long-term benefits of these agents in particular types of patient, including patients with moderate or low baseline cholesterol levels pre-treatment, women, the elderly, and those with prior occlusive non-coronary vascular disease. The Heart Protection Study was designed to resolve these uncertainties and to provide substantially more safety information of statins. In this report the study is presented with the significance and practical implications of the results briefly discussed.
authors.affiliation: Department of Cardiology and Cardiovascular Surgery, Hamad Medical Corporation, PO Box 3050, Doha, Qatar. amaramin@yahoo.com
authors.forename: Amar M
authors.initials: AM
authors.lastname: Salam
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000209:etiology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors