Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice.
Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial working memory (SWM) tasks, although their spatial reference memory remains normal. Here we show that forebrain-localized expression of GFP-tagged GluR-A subunits in GluR-A-deficient mice rescues SWM, paralleling its rescue of CA3-CA1 LTP. This provides powerful new evidence linking hippocampal GluR-A-dependent synaptic plasticity to rapid, flexible memory processing.
Schmitt
W B
WB
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK.
Sprengel
R
R
Mack
V
V
Draft
R W
RW
Seeburg
P H
PH
Deacon
R M J
RM
Rawlins
J N P
JN
Bannerman
D M
DM
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002452:Cell Count / Q000379:methods; D004195:Disease Models, Animal; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000503:physiopathology; D007150:Immunohistochemistry / Q000379:methods; D066298:In Vitro Techniques; D007211:Indoles; D017774:Long-Term Potentiation / Q000235:genetics; D008569:Memory Disorders / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D008570:Memory, Short-Term / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D017966:Pyramidal Cells / Q000502:physiology; D018091:Receptors, AMPA / Q000172:deficiency* / Q000235:genetics; D013028:Space Perception / Q000502:physiology*; D014161:Transduction, Genetic
D049452:Green Fluorescent Proteins; D007211:Indoles; D018091:Receptors, AMPA; C007293:DAPI