Production of a proteolytically active protein, chlamydial protease/proteasome-like activity factor, by five different Chlamydia species.
We have previously identified a chlamydial protein, chlamydial protease/proteasome-like activity factor (CPAF), for degrading host transcription factors in cells infected with the human chlamydial species Chlamydia trachomatis or Chlamydia pneumoniae. We now report that functional CPAF was also produced during infection with the species Chlamydia muridarum, Chlamydia psittaci, and Chlamydia caviae, which primarily infect nonhuman hosts.
Dong
Feng
F
Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA.
Zhong
Youmin
Y
Arulanandam
Bernard
B
Zhong
Guangming
G
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002689:Chlamydia / Q000145:classification* / Q000201:enzymology* / Q000472:pathogenicity; D004268:DNA-Binding Proteins / Q000378:metabolism; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D000071701:Regulatory Factor X Transcription Factors
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C093524:RFX5 protein, human; D011993:Recombinant Fusion Proteins; D000071701:Regulatory Factor X Transcription Factors; D005982:Glutathione Transferase; D046988:Proteasome Endopeptidase Complex
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