title: Antiphospholipid antibodies in patients with sensorineural hearing loss.
abstract: Sensorineural hearing loss can be associated with autoimmune diseases and the presence of antiphospholipid antibodies. Sixty patients (mean age 47 years, range 18-76 years) with sudden sensorineural hearing loss were studied with audiograms, stapedial thresholds, otoacoustic emissions, positional and caloric testing. The serologic testing included antibodies against phosphatidylserine and beta(2)-glycoprotein. Additionally, a group of 34 patients (mean age 65 years, range 31-81 years) with normal tension glaucoma was examined because in a previous study these patients were reported to have elevated concentrations of antiphospholipid antibodies with a coincidence of progressive sensorineural hearing loss. The baseline for antiphospholipid antibody levels was established in a control group of 40 healthy blood donors. In 12 of the 60 patients with sudden sensorineural hearing loss, levels of antiphospholipid antibodies were elevated. Antiphosphatidylserine IgM antibodies were significantly lower compared to controls and patients with the combination of hearing loss and normal tension glaucoma (Fisher's exact two-sided test, P < 0.01). Our data suggest that antibodies against beta2-glycoprotein seem to coincidence with an acute event, such as sudden sensorineural hearing loss, whereas antibodies against phosphatidylserine IgG are detectable in the prolonged sequel, such as in patients with progressive sensorineural hearing loss and normal tension glaucoma.
authors.affiliation: Department of Otorhinolaryngology, University Hospital Essen, Germany. edgar.bachor@klinikum-badsalzungen.de
authors.forename: Edgar
authors.initials: E
authors.lastname: Bachor
authors.forename: Stephan
authors.initials: S
authors.lastname: Kremmer
authors.forename: Ernst
authors.initials: E
authors.lastname: Kreuzfelder
authors.forename: Klaus
authors.initials: K
authors.lastname: Jahnke
authors.forename: Said
authors.initials: S
authors.lastname: Seidahmadi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005901:Glaucoma / Q000097:blood* / Q000150:complications; D006023:Glycoproteins / Q000097:blood; D006319:Hearing Loss, Sensorineural / Q000097:blood* / Q000150:complications; D003639:Hearing Loss, Sudden / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010718:Phosphatidylserines / Q000276:immunology*; D053482:beta 2-Glycoprotein I
chemical_list: D017152:Antibodies, Antiphospholipid; D006023:Glycoproteins; D010718:Phosphatidylserines; D053482:beta 2-Glycoprotein I
references.citation: Ann Otol Rhinol Laryngol. 2003 Aug;112(8):722-8
references.pmid: 12940672
references.citation: Am J Otolaryngol. 1993 Jul-Aug;14(4):275-7
references.pmid: 8214323
references.citation: Otol Neurotol. 2002 May;23(3):316-22
references.pmid: 11981388
references.citation: Clin Otolaryngol Allied Sci. 2002 Dec;27(6):458-63
references.pmid: 12472512
references.citation: Am J Otol. 1986 May;7(3):210-3
references.pmid: 3717314
references.citation: J Rheumatol. 1998 Mar;25(3):589-92
references.pmid: 9517786
references.citation: Lancet. 1999 Nov 20;354(9192):1803-10
references.pmid: 10577657
references.citation: Dtsch Med Wochenschr. 1998 May 22;123(21):663-6
references.pmid: 9638094
references.citation: Lancet. 2002 Sep 21;360(9337):915-21
references.pmid: 12354474
references.citation: Adv Otorhinolaryngol. 1991;46:71-7
references.pmid: 1927719
references.citation: Otol Neurotol. 2002 Mar;23(2):160-2
references.pmid: 11875344
references.citation: Hematology Am Soc Hematol Educ Program. 2003;:497-519
references.pmid: 14633796
references.citation: Br J Ophthalmol. 2004 Oct;88(10):1259-62
references.pmid: 15377546
references.citation: Acta Otolaryngol. 2001 Jan;121(1):28-34
references.pmid: 11270490
references.citation: Autoimmunity. 2000;32(1):39-44
references.pmid: 10958174
references.citation: Annu Rev Med. 2003;54:409-24
references.pmid: 12414917
references.citation: Laryngoscope. 1984 May;94(5 Pt 1):647-61
references.pmid: 6325838
references.citation: Lupus. 2003;12(7):514-7
references.pmid: 12892390
references.citation: Otol Neurotol. 2002 Jul;23(4):517-20; discussion 520-1
references.pmid: 12170155
references.citation: Ann Intern Med. 1997 Mar 15;126(6):450-3
references.pmid: 9072930
references.citation: Otolaryngol Head Neck Surg. 1986 Feb;94(2):197-204
references.pmid: 3083335
references.citation: Ann Otol Rhinol Laryngol. 2002 Nov;111(11):989-97
references.pmid: 12450172
references.citation: Z Laryngol Rhinol Otol. 1958 Jan;37(1):1-16
references.pmid: 13531469
references.citation: Medicine (Baltimore). 1998 May;77(3):195-207
references.pmid: 9653431