[Current advances in leprosy research activities].
Due to the advent of multi-drug therapy (MDT) recommended by the WHO, for the treatment of leprosy, presently, leprosy is regarded as a "curable disease". The number of new cases in Japan is relatively very low, due to which the disease is likely to be neglected, but on scientific grounds, there is a necessity to perform in depth studies. Leprosy caused by M. leprae is still unclear on various aspects including transmission, immunology, nerve damage etc. Here we introduce the recent advances in the field of basic leprosy research.
Makino
Masahiko
M
Department of Microbiology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo 189-0002, Japan. mmaki@nih.go.jp
Suzuki
Koichi
K
Fukutomi
Yasuo
Y
Yamashita
Yasuko
Y
Maeda
Yumi
Y
Miyamoto
Yuji
Y
Mukai
Tetsu
T
Nakata
Noboru
N
Kai
Masanori
M
Ymazaki
Toshio
T
Gidoh
Msaichi
M
Matsuoka
Masanori
M
D000818:Animals; D017951:Antigen Presentation; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000502:physiology; D001428:Bacterial Vaccines; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D003713:Dendritic Cells / Q000276:immunology; D015195:Drug Design; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006017:Glycolipids; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007917:Leprostatic Agents; D007918:Leprosy / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D008562:Membrane Glycoproteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D018598:Minisatellite Repeats / Q000235:genetics; D025202:Molecular Diagnostic Techniques / Q000379:methods; D017720:Molecular Epidemiology; D009166:Mycobacterium leprae / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000502:physiology; D012583:Schwann Cells / Q000382:microbiology; D051193:Toll-Like Receptors; D015533:Transcriptional Activation
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D016207:Cytokines; D006017:Glycolipids; D007917:Leprostatic Agents; C464640:LpK protein, Mycobacterium leprae; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; C060596:anti-leprosy vaccine; C045169:phenolic glycolipid I, Mycobacterium leprae