title: Could activity in anterior frontal regions predict performance on declarative memory tests?
abstract: Few studies have tested the correlation between traditional declarative memory scores and functional brain imaging measures of memory. We examined the predictable capabilities of magnetoencephalography-derived measures, scanned during a high-load encoding-memory task, in the immediate (LM-1) and delayed (LM-2) recall from the Wechsler memory scale. The number of activity sources on the left frontal pole (between 300 and 600 ms) predicted scores in LM-1 and LM-2. Collapsing the activity in the left frontal pole and the orbitofrontal cortex increased the goodness of the solution for the LM-2 scores. The fact that rostral-frontal measures achieved significant values highlights the importance of executive processes, such as the implementation of memory strategies and top-down control mechanisms, in the performance of high-load memory tasks.
authors.affiliation: Centro de Magnetoencefalografía Dr Pérez-Modrego, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Maestú
authors.forename: Nuria
authors.initials: N
authors.lastname: Paul
authors.forename: Juan-Manuel
authors.initials: JM
authors.lastname: Muñoz-Céspedes
authors.forename: Pablo
authors.initials: P
authors.lastname: Campo
authors.forename: Marcos
authors.initials: M
authors.lastname: Ríos
authors.forename: Juan
authors.initials: J
authors.lastname: Alvarez-Linera
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernandez
authors.forename: Tomas
authors.initials: T
authors.lastname: Ortiz
mesh_terms: D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology; D011939:Mental Recall / Q000502:physiology*; D011237:Predictive Value of Tests; D011597:Psychomotor Performance / Q000502:physiology*