ATP-dependent chromatin remodeling complexes and their role in nuclear receptor-dependent transcription in vivo.
Nuclear receptors (NRs) are ligand-dependent transcription factors that mediate transcription of target genes in chromatin. Modulation of chromatin structure plays an important part in the NR-mediated transcription process. ATP-dependent chromatin remodeling complexes have been shown to be intimately involved in NR-mediated transcription. In this review, we examine the role of chromatin remodeling complexes in facilitating the recruitment of coregulators and basal transcription factors. In addition, the role of subunit specificity within the chromatin remodeling complexes, the complexes' influence on remodeling activity, and complexes' recruitment to the NR-responsive promoters are discussed.
Aoyagi
Sayura
S
Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.
Trotter
Kevin W
KW
Archer
Trevor K
TK
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D014158:Transcription, Genetic
D002843:Chromatin; D018160:Receptors, Cytoplasmic and Nuclear; D000255:Adenosine Triphosphate