[Time-effect relationship for unstable chromosome exchange levels in Chernobyl clean-up workers].
The post-irradiation changes of dicentric and centric ring levels were studied in Chernobyl liquidators using the data of 507 individual chromosomal surveys of persons sampled at different time after their activities at Chernobyl NPP accident zone. The time-effect relationship within 0-10.5 years after exposure was displayed as exponential decline of the mean chromosome exchange frequency with average decay half-time 2.2 y. During 10.5-13 years after exposure the increasing and stabilization of chromosome exchange yield on the level 2-3-times higher than control was observed. In the first few months after irradiation the dicentric and centric ring frequency in liquidators had the clear reverse correlation with the duration of person's duties at the Chernobyl zone. The parameters of unstable chromosome exchange elimination were independent on the initially induced aberration yield, that resulted in earlier reaching the subcontrol level in persons who had more protracted duration of duties at the Chernobyl accident zone.
Maznik
N A
NA
Vinnikov
V A
VA
D000328:Adult; D000368:Aged; D047852:Chernobyl Nuclear Accident; D043171:Chromosomal Instability / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000528:radiation effects*; D015331:Cohort Studies; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis*; D011829:Radiation Dosage; D012303:Ring Chromosomes; D012854:Sister Chromatid Exchange / Q000528:radiation effects; D013997:Time Factors; D014455:Ukraine