title: ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia.
abstract: Different studies have investigated the effect of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism on the risk of Alzheimer dementia (AD). However, results on the association of the ACE-I allele with AD have been inconclusive. A recent meta-analysis reported an association of the I-allele with the risk of AD. A few small studies also investigated the effect of ACE polymorphism on the risk of vascular dementia (VD). We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. We found the I/I genotype to be associated with an increased risk of AD, but not with the risk of VD. Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD.
authors.affiliation: Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. heike.koelsch@ukb.uni-bonn.de
authors.forename: H
authors.initials: H
authors.lastname: Kölsch
authors.forename: F
authors.initials: F
authors.lastname: Jessen
authors.forename: N
authors.initials: N
authors.lastname: Freymann
authors.forename: M
authors.initials: M
authors.lastname: Kreis
authors.forename: F
authors.initials: F
authors.lastname: Hentschel
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: R
authors.initials: R
authors.lastname: Heun
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology / Q000235:genetics*; D004251:DNA Transposable Elements / Q000235:genetics; D015140:Dementia, Vascular / Q000201:enzymology / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A