Molecular regulation of mullerian development by Hox genes.
HOX genes are a family of regulatory molecules that encode conserved transcription factors controlling aspects of morphogenesis and cell differentiation during normal embryonic development. All metazoans possess a common genetic system for embryonic patterning, and this system is also used in the reproductive tract. Hox genes are also expressed in the adult uterus. Hox genes are essential both for the development of mullerian tract in the embryonic period and adult function. Sex steroids regulate Hox gene expression during embryonic and endometrial development in the menstrual cycle. EMX2 and beta(3)-integrin acting downstream of Hoxa10 gene are likely involved in both these developmental processes. This article reviews the role and molecular regulation of Hox genes in reproductive tract development.
DU
Hongling
H
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Yale University School of Medicine, 333 Cedar Street, P.O. Box 2008063, New Haven, CT 06520, USA.
Taylor
Hugh S
HS
D000818:Animals; D005260:Female; D005801:Genes, Homeobox / Q000502:physiology*; D006801:Humans; D009095:Mullerian Ducts / Q000196:embryology* / Q000502:physiology*; D012098:Reproduction / Q000502:physiology*