Analysis of the blood level of micafungin involving patients with hematological diseases: new findings regarding combination therapy with tacrolimus.
In 29 patients (40 samples) with hematological diseases who had been treated with a candin antifungal agent, micafungin (MCFG), we measured the blood level of MCFG by high-performance liquid chromatography (HPLC). There was a correlation between the dose and the blood level of MCFG (r = 0.729, p < 0.001). In addition, there was a correlation between the total bilirubin level and the C/D value (r = 0.458, p < 0.01), which was calculated by dividing the blood level of MCFG by the dose, although there was no correlation between creatinine clearance and the C/D value. These findings suggest that the dose of MCFG must be regulated in patients with biliary stasis-type liver hypofunction. In addition, there was no significant difference in the blood level of MCFG between the group in which tacrolimus (FK506) was combined with MCFG and the group in which MCFG alone was administered. These results suggest that there are no changes in the blood level of MCFG even when MCFG is combined with FK506.
Shimoeda
Sadahiko
S
Department of Pharmacy, Nagano Red Cross Hospital, Wakasato, Nagano, Nagano, Japan. sadahikoshimoeda@nail.goo.ne.jp
Ohta
Shin
S
Kobayashi
Hikaru
H
Saitou
Hiroshi
H
Kubota
Ai
A
Yamato
Susumu
S
Shimada
Kenji
K
Sasaki
Mutsuko
M
Kawano
Kenji
K
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D054714:Echinocandins; D005260:Female; D006402:Hematologic Diseases / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D055666:Lipopeptides; D008074:Lipoproteins / Q000008:administration & dosage* / Q000097:blood*; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000008:administration & dosage* / Q000097:blood*; D016559:Tacrolimus / Q000008:administration & dosage*
D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D000077551:Micafungin; D016559:Tacrolimus