Amyloid tumor of the larynx associated with plasma cell infiltration: differential diagnosis.
Localized amyloidosis of the larynx is uncommon, accounting for fewer than 1% of all benign laryngeal tumors. We report 2 cases of laryngeal amyloidosis in which dense plasma cell infiltrates were found in the vicinity of the amyloid deposits; in view of this finding, we suspected a hematologic disease--plasmacytoma in particular: However, molecular genetic analysis did not demonstrate any light-chain restriction, indicating that the plasma cells were of polyclonal origin and therefore consistent with chronic inflammation. We also discuss the available literature with respect to diagnostic and therapeutic procedures in patients with amyloidosis of the upper airway.
Benning
Susanne
S
Department of Otorhinolaryngology, Albert Ludwigs University Medical School, Freiburg, Germany.
Technau-Ihling
Katja
K
Fisch
Paul
P
Fradis
Milo
M
Schipper
Joerg
J
Maier
Wolfgang
W
D000368:Aged; D000682:Amyloid / Q000096:biosynthesis* / Q000737:chemistry / Q000145:classification; D000686:Amyloidosis / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007249:Inflammation; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells
D000682:Amyloid