Stromelysin-1 (MMP-3) gene 5A/6A promoter polymorphism is associated with blood pressure in a community population.
OBJECTIVE
Arterial remodelling contributes to the development of hypertension. Stromelysin-1 (MMP-3), a member of the matrix metalloproteinase family may contribute to this process. Stromelysin-1 gene expression is partly regulated by a common polymorphism in the promoter region of either five or six consecutive adenosine bases (5A/6A).


RESULTS
A cross-sectional study of 1111 randomly selected male and female community subjects (27-77 years), were assessed for conventional cardiovascular risk factors and stromelysin-1 5A-1171-6A genotype. Multivariate analysis showed an independent association between the stromelysin-1 genotype and blood pressure that was recessive for the 5A/5A genotype. Subjects with the 5A/5A genotype had a higher mean systolic blood pressure (SBP) (+4.2 mmHg) and diastolic blood pressure (DBP) (+2.2 mmHg) compared to subjects with 5A/6A and 6A/6A genotypes. Subgroup analysis revealed an independent association of the 5A/5A genotype with SBP (+3.6 mmHg, P = 0.001) and DBP (+2.0 mmHg, P = 0.004) in subjects not on blood pressure medication. Whereas subjects with the 5A/5A genotype and taking medication had a higher mean SBP (+7.4 mmHg, P = 0.02) and DBP (+2.7 mmHg, P = 0.11). Multivariate analysis in the whole population showed there was no association between genotypes and mean intimal-medial wall thickness (IMT) (P = 0.87) or the likelihood of carotid plaque formation.


CONCLUSIONS
The stromelysin-1 5A-1171-6A genotype is an important determinant of blood pressure in this general population sample.
Beilby
John P
JP
Clinical Biochemistry, Western Australian Centre for Pathology and Medical Research (PathCentre) and School of Surgery and Pathology, University of Western Australia, Perth, Western Australia. John.Beilby@health.wa.gov.au
Chapman
Caroline M L
CM
Palmer
Lyle J
LJ
McQuillan
Brendan M
BM
Thompson
Peter L
PL
Hung
Joseph
J
D000241:Adenosine / Q000235:genetics; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000235:genetics*; D002339:Carotid Arteries / Q000473:pathology; D002340:Carotid Artery Diseases / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors
D019278:Matrix Metalloproteinase 3; D000241:Adenosine