Magnetic resonance imaging of atherosclerosis.
Abundant data now link composition of the vascular wall, rather than the degree of luminal narrowing, with the risk for acute ischemic syndromes in the coronary, central nervous system, and peripheral arterial beds. Over the past few years, magnetic resonance angiography has evolved as a well-established method to determine the location and severity of advanced, lumen-encroaching atherosclerotic lesions. In addition, more recent studies have shown that high spatial resolution, multisequence MRI is also a promising tool for noninvasive, serial imaging of the aortic and carotid vessel wall, which potentially can be applied in the clinical setting. Because of the limited spatial resolution of current MRI techniques, characterization of coronary vessel wall atherosclerosis, however, is not yet possible and remains the holy grail of plaque imaging. Recent technical developments in MRI technology such as dedicated surface coils, the introduction of 3.0-T high-field systems and parallel imaging, as well as developments in the field of molecular imaging such as contrast agents targeted to specific plaque constituents, are likely to lead to the necessary improvements in signal to noise ratio, imaging speed, and specificity. These improvements will ultimately lead to more widespread application of this technology in clinical practice. In the present review, the current status and future role of MRI for plaque detection and characterization are summarized.
Leiner
T
T
Department of Radiology, Maastricht University Hospital, The Netherlands. leiner@rad.unimaas.nl
Gerretsen
S
S
Botnar
R
R
Lutgens
E
E
Cappendijk
V
V
Kooi
E
E
van Engelshoven
J
J
D001161:Arteriosclerosis / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*
D003287:Contrast Media
J Magn Reson Imaging. 2004 Apr;19(4):459-67
15065170
Eur Radiol. 2002 Apr;12(4):889-900
11960244
Ann N Y Acad Sci. 2000 May;902:173-86
10865837
Eur Radiol. 2003 Sep;13(9):2094-8
12692681
Arterioscler Thromb Vasc Biol. 2003 Dec;23(12):2123-30
14512372
Arterioscler Thromb Vasc Biol. 2001 Oct;21(10):1623-9
11597936
Arterioscler Thromb Vasc Biol. 1997 Aug;17(8):1496-503
9301626
Radiology. 2002 May;223(2):566-73
11997569
Radiology. 1991 Dec;181(3):655-60
1947077
Circulation. 2000 Aug 29;102(9):959-64
10961958
J Magn Reson Imaging. 2004 Jun;19(6):710-9
15170778
J Magn Reson Imaging. 1994 Jan-Feb;4(1):43-9
8148555
Circulation. 2002 Aug 13;106(7):804-8
12176951
Circulation. 2000 Aug 1;102(5):506-10
10920061
Arterioscler Thromb Vasc Biol. 2000 May;20(5):1262-75
10807742
Magn Reson Med. 2003 Feb;49(2):341-50
12541255
Circulation. 2002 Jan 15;105(2):181-5
11790698
Circulation. 2002 Jul 16;106(3):296-9
12119242
Magn Reson Med. 2002 Nov;48(5):899-905
12418006
J Clin Invest. 1998 Apr 15;101(8):1551-6
9541483
Eur Radiol. 2003 Nov;13(11):2505-12
12920562
J Magn Reson Imaging. 2003 May;17(5):615-9
12720273
Magn Reson Med. 2002 Mar;47(3):616-20
11870851
Nature. 2000 Sep 14;407(6801):233-41
11001066
N Engl J Med. 2000 Sep 28;343 (13):915-22
11006367
Radiology. 1993 Oct;189(1):15-26
8372185
J Magn Reson Imaging. 1996 Jan-Feb;6(1):109-12
8851414
Stroke. 2002 Apr;33(4):977-81
11935047
Circulation. 2004 Apr 27;109(16):2023-9
15066940
J Investig Med. 2001 Nov;49(6):491-9
11730084
Radiology. 2001 May;219(2):403-10
11323464
J Magn Reson Imaging. 2002 Mar;15(3):344-51
11891981
J Am Coll Cardiol. 2001 Apr;37(5):1430-5
11300457
Circulation. 2001 Sep 11;104(11):1280-5
11551880
Magn Reson Med. 1998 Apr;39(4):635-41
9543426
Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):346-50
12588782
Circulation. 2000 Nov 21;102(21):2582-7
11085960
Radiology. 2005 Feb;234(2):487-92
15671004
Arterioscler Thromb Vasc Biol. 1995 Oct;15(10):1533-42
7583524
Neuroimaging Clin N Am. 2002 Aug;12(3):391-401, vi
12486828
Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):650-7
14764423
J Magn Reson Imaging. 2003 Apr;17(4):478-83
12655588
J Magn Reson Imaging. 2002 Jan;15(1):62-7
11793458
Magn Reson Med. 1999 Nov;42(5):952-62
10542355
Magn Reson Med. 2000 Dec;44(6):867-72
11108623
Circulation. 2003 May 20;107(19):2453-8
12719280
Circulation. 2003 Feb 18;107(6):851-6
12591755
Radiology. 1991 May;179(2):499-504
2014300
Radiographics. 1997 Nov-Dec;17(6):1417-23
9397455
Circulation. 2002 Sep 10;106(11):1368-73
12221054
N Engl J Med. 1999 Jan 14;340(2):115-26
9887164
Nature. 2002 Dec 19-26;420(6917):868-74
12490960
Circulation. 1999 Nov 30;100(22):2284-301
10578005
Arterioscler Thromb Vasc Biol. 1999 Nov;19(11):2756-61
10559022
J Vasc Interv Radiol. 2004 Jan;15(1 Pt 1):25-38
14709684
Magn Reson Med. 1995 Aug;34(2):186-93
7476077
Radiology. 2001 Nov;221(2):285-99
11687667
J Magn Reson Imaging. 2004 Jul;20(1):105-10
15221815
J Thromb Haemost. 2003 Jul;1(7):1403-9
12871274
Invest Radiol. 2003 Jul;38(7):452-9
12821860
Neuroimaging Clin N Am. 2002 Aug;12(3):351-64
12486824
Circulation. 2004 Jun 15;109(23):2890-6
15184290
J Magn Reson Imaging. 2000 Nov;12(5):671-7
11050636
Circulation. 2002 Dec 3;106(23):2884-7
12460866
Circulation. 2003 Jun 24;107(24):3053-8
12796136
J Cardiovasc Magn Reson. 2001;3(4):331-8
11777225
Am Heart J. 2004 May;147(5):808-14
15131535
Circulation. 1996 Sep 1;94(5):932-8
8790028
Arterioscler Thromb Vasc Biol. 2002 May 1;22(5):849-54
12006401
Magn Reson Med. 2002 May;47(5):1017-21
11979583
Circulation. 2000 May 30;101(21):2503-9
10831525
J Magn Reson Imaging. 2003 May;17(5):538-44
12720263
J Cardiovasc Magn Reson. 2003;5(4):589-94
14664136
Magn Reson Med. 1999 Oct;42(4):738-45
10502763
Magn Reson Imaging Clin N Am. 1993 Dec;1(2):349-57
7584229
J Magn Reson Imaging. 2003 Apr;17(4):410-20
12655579
Circulation. 2004 Sep 14;110(11):1463-6
15238457
Circulation. 2001 Oct 23;104(17):2051-6
11673345
Circulation. 2002 Oct 8;106(15):2026-34
12370230