title: Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton.
abstract: The cloning and functional expression of Mycobacterium tuberculosis Rv3377c in Escherichia coli revealed that this gene encodes the diterpene cyclase for producing (+)-5(6),13-halimadiene-15-ol, which accepts geranylgeranyldiphosphate as the intrinsic substrate.
authors.affiliation: Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, Ikarashi, Niigata, 950-2181, Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nakano
authors.forename: Tomoo
authors.initials: T
authors.lastname: Okamura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Tohru
authors.initials: T
authors.lastname: Dairi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hoshino
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics*; D003001:Cloning, Molecular; D003500:Cyclization; D004224:Diterpenes / Q000737:chemistry*; D004926:Escherichia coli / Q000235:genetics; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000201:enzymology* / Q000235:genetics*
chemical_list: C518124:5(6),13-halimadiene-15-ol; D001426:Bacterial Proteins; D004224:Diterpenes