title: Imaging of dopamine transporters and D2 receptors in vascular parkinsonism: a report of four cases.
abstract: The role of nuclear medicine imaging in the diagnosis of vascular parkinsonism (VP) has been addressed by only few studies up to now. Most previous reports suggest no or only mild impairment of DAT and D2 receptors in VP. In contrast, in four patients with VP, reported here, the combined DAT and D2 receptor SPECT showed highly unusual changes in the pre- and/or postsynaptic dopaminergic system. The possible value of combined DAT/D2 receptor SPECT imaging should be investigated by future prospective studies.
authors.affiliation: Department of Radiology, Nuclear Medicine and Radiooncology, Berlin, Germany. michail.plotkin@charite.de
authors.forename: M
authors.initials: M
authors.lastname: Plotkin
authors.forename: H
authors.initials: H
authors.lastname: Amthauer
authors.forename: S
authors.initials: S
authors.lastname: Quill
authors.forename: F
authors.initials: F
authors.lastname: Marzinzik
authors.forename: F
authors.initials: F
authors.lastname: Klostermann
authors.forename: S
authors.initials: S
authors.lastname: Klaffke
authors.forename: A
authors.initials: A
authors.lastname: Kivi
authors.forename: M
authors.initials: M
authors.lastname: Gutberlet
authors.forename: R
authors.initials: R
authors.lastname: Felix
authors.forename: A
authors.initials: A
authors.lastname: Kupsch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001549:Benzamides; D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation; D015140:Dementia, Vascular / Q000000981:diagnostic imaging / Q000378:metabolism; D018492:Dopamine Antagonists; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014326:Tropanes
chemical_list: D001549:Benzamides; D002250:Carbon Radioisotopes; D018492:Dopamine Antagonists; D050483:Dopamine Plasma Membrane Transport Proteins; D007457:Iodine Radioisotopes; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide
references.citation: Neuroepidemiology. 1994;13(3):108-12
references.pmid: 8015663
references.citation: J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4
references.pmid: 1564476
references.citation: Acta Neurol Scand. 2001 Aug;104(2):63-7
references.pmid: 11493219
references.citation: J Nucl Med. 2001 Mar;42(3):408-13
references.pmid: 11337515
references.citation: Acta Neurol Scand. 1996 Jun;93(6):387-92
references.pmid: 8836298
references.citation: Mov Disord. 1995 Jul;10(4):450-4
references.pmid: 7565825
references.citation: Acta Neuropathol. 2003 May;105(5):415-9
references.pmid: 12677440
references.citation: Mov Disord. 2003 Dec;18(12 ):1415-23
references.pmid: 14673877
references.citation: Mov Disord. 2002 May;17 (3):518-23
references.pmid: 12112200
references.citation: Stroke. 1986 Nov-Dec;17(6):1084-9
references.pmid: 3810705
references.citation: Arch Neurol. 1999 Jan;56(1):98-102
references.pmid: 9923767
references.citation: J Neural Transm (Vienna). 2005 May;112(5):677-92
references.pmid: 15375677
references.citation: Neurology. 1984 Nov;34(11):1516-8
references.pmid: 6493507
references.citation: Neurology. 1995 Dec;45(12):2183-8
references.pmid: 8848190
references.citation: J Neural Transm (Vienna). 2004 Oct;111(10-11):1473-83
references.pmid: 15340870
references.citation: Mov Disord. 2005 Feb;20(2):258-60
references.pmid: 15551348
references.citation: Mov Disord. 2004 Jun;19(6):630-40
references.pmid: 15197700
references.citation: Eur Neurol. 1995;35(1):46-9
references.pmid: 7737247
references.citation: Arch Neurol. 1995 Feb;52(2):191-4
references.pmid: 7848130
references.citation: Brain. 1994 Aug;117 ( Pt 4):859-76
references.pmid: 7922471
references.citation: Stroke. 1988 Oct;19(10 ):1285-8
references.pmid: 3051534
references.citation: Neurology. 1987 Apr;37(4):570-6
references.pmid: 3561771
references.citation: Mov Disord. 1998 Jan;13(1):89-95
references.pmid: 9452332
references.citation: J Neurol. 2004 May;251(5):513-24
references.pmid: 15164182
references.citation: Neurology. 1990 Jun;40(6):897-900
references.pmid: 2345612
references.citation: Stroke. 1997 May;28(5):965-9
references.pmid: 9158634
references.citation: Rinsho Shinkeigaku. 2001 Oct;41(10 ):659-64
references.pmid: 11993184
references.citation: J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):545-7
references.pmid: 15026493