[Effect of kidney peptide preparation on the expression of lymphocyte surface receptors during Na+,K+-ATPase inhibition].
In the work the action of membrane-mediated kidney peptide complex on human periferal blood lymphocytes was studied under Na+,K+-ATPase activity inhibition. It was shown that ouabain pretreatment changed the functional activity of lymphocytes: the surface immunoglobulin expression level was decreased, antigene determinants CD4, CD8 expression were reduced, CD3 expression was increased either. The kidney peptide complex had the modulated influence on the surface receptors, improving the decreased CD4, CD8 and surface immunoglobulins expression and differently influencing the CD3 and CD72 expression. It has been proposed that kidney peptide complex facilitates processes of Na+,K+-ATPase reactivation.
Vesnina
L E
LE
Kaĭdashev
I P
IP
D015703:Antigens, CD / Q000378:metabolism; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007672:Kidney Cortex / Q000737:chemistry*; D008214:Lymphocytes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D015703:Antigens, CD; D004791:Enzyme Inhibitors; D007136:Immunoglobulins; D010455:Peptides; D011956:Receptors, Cell Surface; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase