Evidence of acute ischemic tissue change in transient global amnesia in magnetic resonance imaging: case report and literature review.
Transient global amnesia is a benign syndrome of sudden-onset alteration of behavior with temporary dysfunction of anterograde and recent retrograde memory. Its neural substrates remain uncertain. Possible causes include ischemia, migraine, and epilepsy. The authors report a case of a 62-year-old man with a transient attack of memory disturbance, suggestive of transient global amnesia, in which magnetic resonance imaging performed 48 hours after onset showed left mesial temporal lobe signal changes on diffusion-weighted imaging and fluid-attenuated inversion recovery images. The findings and a literature review lend further support to the ischemic pathogenesis of transient global amnesia as a possible etiology, and underscore the role of diffusion-weighted imaging in the diagnosis of this condition.
Felix
Marcelo M
MM
Department of Radiology, Hospital das Clínicas-Universidade de São Paulo and Section of Radiology, Fleury Centro de Medicina Diagnostica, Brazil. felixmf@bol.com.br
Castro
Luiz H M
LH
Maia
Antonio Carlos Martins
AC
da Rocha
Antonio J
AJ
D020236:Amnesia, Transient Global / Q000209:etiology*; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005500:Follow-Up Studies; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000473:pathology