title: Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection.
abstract: CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved hepatitis B virus (HBV) infection. We demonstrated that circulating CD4+ CD25+ T cells modulate the function and expansion of HBV-specific CD8+ cells ex vivo in all patients, regardless of whether they have chronic or resolved HBV infection. The possible role of CD4+ CD25+ T cells in the pathogenesis of chronic HBV infection is not supported by these data. However, these results might have implications for optimizing future immunotherapeutic approaches to HBV treatment.
authors.affiliation: Institute of Hepatology, University College London, 69-75 Chenies Mews, London WC1E 6HX, United Kingdom. a.bertoletti@ucl.ac.uk.
authors.forename: Ornella
authors.initials: O
authors.lastname: Franzese
authors.forename: Patrick T F
authors.initials: PT
authors.lastname: Kennedy
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Gehring
authors.forename: Jim
authors.initials: J
authors.lastname: Gotto
authors.forename: Roger
authors.initials: R
authors.lastname: Williams
authors.forename: Mala K
authors.initials: MK
authors.lastname: Maini
authors.forename: Antonio
authors.initials: A
authors.lastname: Bertoletti
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D049109:Cell Proliferation; D002478:Cells, Cultured; D004279:DNA, Viral / Q000097:blood; D006510:Hepatitis B Antibodies / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000276:immunology / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006513:Hepatitis B e Antigens; D015375:Receptors, Interleukin-2
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