title: [Perioperative management of orthopaedic patients with hemophilia A].
abstract: OBJECTIVE
  To discuss the perioperative management of hemophiliacs A with orthopaedic complications.
  
  
  METHODS
  To regulate the injection of factor VIII concentrate in peroperative period by testing the level of factor VIII:C in 27 cases. The lever of factor VIII:C was improved to 30% - 50% at the day before the operation. To the severe patients, it was maintained at 58.5% - 89.3% during the operation and at 47.0% - 78.4% in postoperation. While to the gentle, it was maintained at 38.5% - 52.5% during the operation and at 29.2% - 52.3% in postoperation. The individualized surgical procedures were carried out, such as arthrocentesis, open knee synovectomy or arthroscopic synovectomy, evacuation or curettage of haematoma, debridements, internal fixation.
  
  
  RESULTS
  All patients were cured in 14 - 105 days by regulating the injection of factor VIII during the peroperative period. The usage of factor VIII was 1 200 - 70 250 IU.
  
  
  CONCLUSIONS
  While the hemophiliacs have orthopaedic complications, it is necessary to promise the factor VIII:C being maintained at the lever of hemostasis during the peroperative period. The hemophiliacs are endurable to the operation.
authors.affiliation: Department of Orthopaedics, Shandong Qianfoshan Hospital, Jinan 250014, China. wygglj@sohu.com
authors.forename: Ying-guang
authors.initials: YG
authors.lastname: Wu
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Li
authors.forename: Kai-ning
authors.initials: KN
authors.lastname: Zhang
authors.forename: Yan-jun
authors.initials: YJ
authors.lastname: Ren
authors.forename: Shu-feng
authors.initials: SF
authors.lastname: Li
authors.forename: Mei-yuan
authors.initials: MY
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D005169:Factor VIII / Q000008:administration & dosage*; D050723:Fractures, Bone / Q000150:complications / Q000601:surgery*; D006395:Hemarthrosis / Q000209:etiology / Q000601:surgery*; D006406:Hematoma / Q000209:etiology / Q000601:surgery; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D019990:Perioperative Care; D011183:Postoperative Complications / Q000097:blood
chemical_list: D005169:Factor VIII