title: Relation of family history of premature coronary heart disease and metabolic risk factors to risk of coronary arterial calcium in asymptomatic subjects.
abstract: We studied 6,141 consecutive, asymptomatic, nondiabetic patients who underwent electron beam tomography and explored the interaction between metabolic risk factors (RFs) and premature family history (FH) of coronary heart disease (CHD) in predicting the presence and severity of coronary arterial calcium (CAC). In the presence of >2 metabolic RFs, patients with a positive FH of premature CHD had a significantly higher prevalence of any CAC, CAC >/=100, and CAC >/=75th age-gender percentile than those without a FH of CHD. Our study demonstrated that a familial propensity to subclinical atherosclerosis interacts with the presence of >/=2 metabolic RFs, magnifying the risks for those exposed to both.
authors.affiliation: Ciccarone Preventative Cardiology Center, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
authors.forename: Erin D
authors.initials: ED
authors.lastname: Michos
authors.forename: Khurram
authors.initials: K
authors.lastname: Nasir
authors.forename: John A
authors.initials: JA
authors.lastname: Rumberger
authors.forename: Chandra
authors.initials: C
authors.lastname: Vasamreddy
authors.forename: Joel B
authors.initials: JB
authors.lastname: Braunstein
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Budoff
authors.forename: Roger S
authors.initials: RS
authors.lastname: Blumenthal
mesh_terms: D002114:Calcinosis / Q000453:epidemiology / Q000235:genetics*; D002118:Calcium / Q000378:metabolism; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D003327:Coronary Disease / Q000235:genetics* / Q000378:metabolism*; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000453:epidemiology; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D002118:Calcium