Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity.
Irradiation of amelanotic melanoma B78H1 cells in the presence of liposome-delivered Ni(II)-octabutoxy-naphthalocyanine with a Q-switched Ti:sapphire laser operated in a pulsed mode (850 nm, 30 ns pulses, 10 Hz, 120 mJ pulse -1) promotes a photothermal sensitization process leading to extensive cell inactivation. The photoprocess occurs with identical efficiency in N2-saturated and air-equilibrated media, indicating that this photosensitization modality does not require the presence of oxygen.
Camerin
Monica
M
Department of Biology, University of Padova, Via U. Bassi 58/B, 35131, PADOVA, Italy.
Rodgers
Michael A J
MA
Kenney
Malcolm E
ME
Jori
Giulio
G
D000388:Air; D000818:Animals; D045744:Cell Line, Tumor; D007834:Lasers; D008546:Melanoma, Experimental / Q000188:drug therapy; D008665:Metalloporphyrins / Q000627:therapeutic use; D051379:Mice; D009584:Nitrogen; D010778:Photochemotherapy / Q000379:methods*; D013997:Time Factors
D008665:Metalloporphyrins; C406454:octabutoxynaphthalocyaninenickel(II); D009584:Nitrogen