The road to survival goes through PARG.
Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase (PARG) has long been a difficult protein to study. However, the complete absence of PARG activity was recently characterized in mice via disruption of the murine PARG gene. As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels. But surprisingly, the disruption of PARG led to embryonic lethality and increased susceptibility to mild cell stress. Therefore, the protective role of PARG and its involvement in development indicate that these roads to viability go through PARG.
Koh
David W
DW
Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Dawson
Valina L
VL
Dawson
Ted M
TM
D000818:Animals; D002453:Cell Cycle; D002470:Cell Survival; D004249:DNA Damage; D005786:Gene Expression Regulation; D006026:Glycoside Hydrolases / Q000235:genetics* / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009154:Mutation; D011108:Polymers / Q000737:chemistry
D011108:Polymers; D006026:Glycoside Hydrolases; C022407:poly ADP-ribose glycohydrolase