title: Metastatic esthesioneuroblastoma in a horse.
abstract: A 17-year-old horse developed severe proptosis of the left eye over a period of 1.5 years. At post-mortem examination a neoplasm was found involving the left ethmoid bone, left maxillary sinus, left orbit, left superior turbinate, and the left eye. Tumour cells were arranged in nests separated by a fine fibrovascular stroma. Immunohistochemically, the tumour cells were labelled by antibodies against neurofilament protein, synaptophysin, glial fibrillary acidic protein and S-100 protein antigen, but were negative for chromogranin A, cytokeratin and desmin. Electronmicroscopically, the cells showed neurosecretory granules with an electron-dense centre and a light halo, and microfilaments. On the basis of macroscopical, light microscopical and ultrastructural findings a diagnosis of a metastatic esthesioneuroblastoma was made.
authors.affiliation: Institut für Pathologie, Tierärztliche Hochschule Hannover, Bünteweg 17, 30559 Hannover, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Döpke
authors.forename: A
authors.initials: A
authors.lastname: Gröne
authors.forename: M
authors.initials: M
authors.lastname: von Borstel
authors.forename: T
authors.initials: T
authors.lastname: von Oppen
authors.forename: M H
authors.initials: MH
authors.lastname: Boéve
authors.forename: W
authors.initials: W
authors.lastname: Baumgärtner
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D018304:Esthesioneuroblastoma, Olfactory / Q000737:chemistry / Q000556:secondary / Q000662:veterinary*; D017809:Fatal Outcome; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D009296:Nasal Cavity / Q000473:pathology*; D009490:Neurosecretory Systems / Q000648:ultrastructure; D009669:Nose Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D022142:Secretory Vesicles / Q000648:ultrastructure
chemical_list: D014408:Biomarkers, Tumor