Inhibition of benzo[a]pyrene induced mutagenicity and genotoxicity by black tea polyphenols theaflavins and thearubigins in multiple test systems.
This study investigated the antimutagenic and anticlastogenic effects of black tea polyphenols, theaflavins (TF) and thearubigins (TR) in Salmonella assay in vitro and in vivo in bone marrow cells of mice as measured by chromosomal aberrations (CA) and sister chromatid exchange (SCE) against a known carcinogen, benzo[a]pyrene (B[a]P). A significant decrease in mutagenicity in Salmonella assay and both CA and SCE were observed in all the different concentrations of TF and TR plus B[a]P treated series when compared with B[a]P treated group alone. These results indicate that both TF and TR have significant antimutagenic and anticlastogenic effects.
Halder
Babli
B
Division of Human Genetics and Genomics, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India.
Pramanick
Swapan
S
Mukhopadhyay
Sibabrata
S
Giri
Ashok Kumar
AK
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001564:Benzo(a)pyrene / Q000633:toxicity*; D044946:Biflavonoids / Q000494:pharmacology*; D001854:Bone Marrow Cells; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002869:Chromosome Aberrations; D004347:Drug Interactions; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D010636:Phenols / Q000494:pharmacology*; D059808:Polyphenols; D012475:Salmonella / Q000235:genetics; D012854:Sister Chromatid Exchange; D013662:Tea / Q000737:chemistry*
D000975:Antioxidants; D044946:Biflavonoids; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; C086701:thearubigin; C056068:theaflavin; D001564:Benzo(a)pyrene; D002392:Catechin