title: Synthesis and highly enantioselective hydrogenation of exocyclic enamides: (Z)-3-arylidene-4-acetyl-3,4-dihydro-2H- 1,4-benzoxazines.
abstract: Highly enantioselective hydrogenation of exocyclic enamides, (Z)-3-arylidene-4-acyl-3,4-dihydro-2H-benzoxazines, was achieved in up to 98.6% ee by using Rh/(R,R)-Me-Duphos complex as the catalytic system. The absolute configuration of the product was assigned as R by chemical interrelations.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, The People's Republic of China. ygzhou@dicp.ac.cn
authors.forename: Yong-Gui
authors.initials: YG
authors.lastname: Zhou
authors.forename: Peng-Yu
authors.initials: PY
authors.lastname: Yang
authors.forename: Xiu-Wen
authors.initials: XW
authors.lastname: Han
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D008968:Molecular Conformation; D010078:Oxazines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D010078:Oxazines