title: Assessment of aortic stiffness and ventricular diastolic functions in patients with Behçet's disease.
abstract: BACKGROUND
  Behçet's disease is a systemic vasculitis in which studies have given conflicting results about ventricular diastolic functions. However, tissue Doppler echocardiography has never been used in any of these studies. Aortic stiffness, a cardiovascular risk factor, may also precede ventricular dysfunction.
  
  
  OBJECTIVE
  The aim of this study was to assess aortic stiffness and biventricular diastolic functions in patients with Behçet's disease.
  
  
  METHODS
  A total of 26 patients with Behçet's disease (mean age; 33+/-10 years) and 20 age- and sex-matched controls (mean age; 33+/-7 years) were included. Aortic stiffness was evaluated by aortic strain and distensibility. Ventricular diastolic functions were evaluated with both conventional and tissue Doppler echocardiography. Mitral E and A wave, E/A ratio of E wave, deceleration time, and isovolumic relaxation time were calculated.
  
  
  RESULTS
  There was no significant difference in diastolic Doppler parameters between patients and controls. Similarly, there was no significant difference in mitral annular E and A velocities between these two groups. Aortic strain in patients with Behçet's disease was found to be significantly less than in the controls (8.3+/-4.9% and 15.7+/-2.7% respectively, p<0.001). Aortic distensibility was also significantly low in patients with Behçet's disease when compared to controls (0.45+/-0.28 and 0.78+/-0.13 respectively, p<0.001). Beta index values were significantly high in Behçet's patients (7.23+/-5.93 and 2.69+/-0.55 respectively, p<0.001).
  
  
  CONCLUSIONS
  No significant diastolic dysfunction was found in left and right ventricles in patients with Behçet's disease by using both conventional and tissue Doppler echocardiography. However, an increase in aortic stiffness was found, suggesting an inflammatory involvement of proximal aorta.
authors.affiliation: Department of Internal Medicine, Division of Rheumatology, Suleyman Demirel University Faculty of Medicine, Istanbul Cad. No:33/8, 32200, Isparta, Turkey. ercantunc@hotmail.com
authors.forename: S Ercan
authors.initials: SE
authors.lastname: Tunc
authors.forename: Abdullah
authors.initials: A
authors.lastname: Dogan
authors.forename: Omer
authors.initials: O
authors.lastname: Gedikli
authors.forename: Cagatay
authors.initials: C
authors.lastname: Arslan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sahin
mesh_terms: D000328:Adult; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001528:Behcet Syndrome / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler / Q000379:methods; D004548:Elasticity; D005260:Female; D006331:Heart Diseases / Q000209:etiology; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D016276:Ventricular Function
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