[Sendai virus proteins counteracting the host innate immunity].
The nucleotide sequence of Sendai virus (SeV) genome was determined in the 1980's. During the analysis of its cDNA, two mRNAs were found to be transcribed from the P gene; one encoding P protein, the other encoding V protein. In addition, C protein was found to be translated from both/ mRNAs. Though the function of V and C proteins was being unknown for a while, the reverse-genetic technique of paramyxoviruses developed at the latter half of the 1990's gave the light on studying them. The V or C protein-knockout-SeV can be made successfully, indicating that the V and C proteins are nonessential for virus growth, However, V knockout-SeV was cleared from the mouse lungs at the one day post inoculation, and C knockout-SeV was cleared immediately after the inoculation. Both V and C proteins were thus appeared to be important for counteracting host innate immunity generated in the early phase of viral infection.
Kato
Atsushi
A
Department of Virology 3, National Institute of Infectious Diseases 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan. akato@nih.go.jp
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000037:antagonists & inhibitors / Q000502:physiology; D010750:Phosphoproteins / Q000502:physiology*; D010766:Phosphorylation; D012333:RNA, Messenger; D012367:RNA, Viral; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000378:metabolism; D010253:Respirovirus Infections / Q000276:immunology* / Q000821:virology*; D050794:STAT1 Transcription Factor; D050795:STAT2 Transcription Factor; D029082:Sendai virus / Q000235:genetics / Q000472:pathogenicity*; D015534:Trans-Activators / Q000378:metabolism; D014764:Viral Proteins / Q000502:physiology*
D004268:DNA-Binding Proteins; D007370:Interferon Type I; C055859:P protein, Sendai virus; D010750:Phosphoproteins; D012333:RNA, Messenger; D012367:RNA, Viral; D017471:Receptors, Interferon; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D050795:STAT2 Transcription Factor; D015534:Trans-Activators; C111739:V protein, Sendai virus; D014764:Viral Proteins; D053633:Receptor, Interferon alpha-beta