title: Protection of inactivated influenza virus vaccine against lethal influenza virus infection in diabetic mice.
abstract: Influenza virus infection frequently causes complications and some excess mortality in the patients with diabetes. Vaccination is an effective measure to prevent influenza virus infection. In this paper, antibody response and protection against influenza virus infection induced by vaccination were studied in mouse model of diabetes. Healthy and diabetic BALB/c mice were immunized once or twice with inactivated influenza virus vaccine at various dosages. Four weeks after the first immunization or 1 week after the second immunization, the mice were challenged with influenza virus at a lethal dose. The result showed that the antibody responses in diabetic mice were inhibited. Immunization once with high dose or twice with low dose of vaccine provided full protection against lethal influenza virus challenge in diabetic mice, however, in healthy mice, immunization only once with low dose provided a full protection.
authors.affiliation: College of Life Science, Hunan Normal University, Changsha, 410081 Hunan, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chang
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Fang
authors.initials: F
authors.lastname: Fang
authors.forename: Changyong
authors.initials: C
authors.lastname: Xue
authors.forename: Fenghua
authors.initials: F
authors.lastname: Zhang
authors.forename: Meizhen
authors.initials: M
authors.lastname: Qiu
authors.forename: Hanzhong
authors.initials: H
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Ze
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000818:Animals; D001835:Body Weight; D002460:Cell Line; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000821:virology*; D004285:Dogs; D005260:Female; D007074:Immunoglobulin G / Q000378:metabolism; D007252:Influenza Vaccines / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009975:Orthomyxoviridae / Q000378:metabolism*; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G; D007252:Influenza Vaccines