title: Y chromosome microdeletions in infertile males from Andhra Pradesh, South India.
abstract: Studies on the frequency of Y chromosome microdeletions were carried out in 70 idiopathic infertile males with normal karyotypes. Genomic DNA was isolated from blood and PCR analysis was carried out with AZFa, AZFb, and AZFc STS markers SY 84, SY 87, SY 127, SY 254, and SY 158 to detect the deletions. In 9/70 (12.8%) subjects AZF deletions were observed. In 4/9 (44.4%) subjects were azoospermic, 4/9 (44.4%) of cases were severe oligozoospermic, and 1/9 (11.1%) cases was oligozoospermic.
authors.affiliation: Institute of Genetics & Hospital for Genetic Diseases, Begumpet, Hyderabad, 500 016, India.
authors.forename: M
authors.initials: M
authors.lastname: Swarna
authors.forename: S Ramesh
authors.initials: SR
authors.lastname: Babu
authors.forename: P P
authors.initials: PP
authors.lastname: Reddy
mesh_terms: D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D056426:Genetic Loci; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007194:India; D007248:Infertility, Male / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D029589:Seminal Plasma Proteins / Q000235:genetics
chemical_list: D005819:Genetic Markers; D029589:Seminal Plasma Proteins