title: Multichannel intraluminal impedance: general principles and technical issues.
abstract: Multichannel intraluminal impedance (MII) is a new technology that allows detection of bolus movement without the use of external radiation or radiolabeled substances. The principles of MII are based on changes in resistance to alternating electrical current (impedance) induced by the presence of various boluses within the esophagus. The timing of changes in multiple impedance-measuring segments in the esophagus allows determination of the direction of bolus movement. Combined MII and manometry (MII-EM) provides simultaneous information on intraesophageal pressures and bolus transit, offers the ability to monitor all types of reflux, and allows the detection of the physical (liquid, gas, or mixed) and chemical (acid, nonacid) characteristics of the gastroesophageal refluxate.
authors.affiliation: Division of Gastroenterology/Hepatology, Medical University of South Carolina, 96 Jonathan Lucas Street, 210 CSB, Charleston, SC 29425, USA. tutuianr@musc.edu
authors.forename: Radu
authors.initials: R
authors.lastname: Tutuian
authors.forename: Donald O
authors.initials: DO
authors.lastname: Castell
mesh_terms: D017097:Electric Impedance; D004594:Electrophysiology; D015154:Esophageal Motility Disorders / Q000175:diagnosis*; D004947:Esophagus / Q000033:anatomy & histology / Q000502:physiology*; D005745:Gastric Acidity Determination; D006801:Humans; D008365:Manometry / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity