title: Influence of vessel diameter on the efficacy of distal protection devices during saphenous vein graft intervention.
abstract: We sought to determine the influence of vessel diameter on the efficacy of distal protection devices during saphenous vein graft intervention. From the Filterwire EX Randomized Evaluation trial, in which patients who underwent saphenous vein graft stenting were randomized to distal protection with the GuardWire or FilterWire EX, outcomes in 572 patients were examined in vessel size tertiles. The 30-day composite incidence of major adverse cardiac events (MACEs) increased with vessel size and was 6.9%, 9.7%, and 14.9% in the smallest, middle, and largest tertiles, respectively (p = 0.04). MACE rates were relatively vessel size independent for the GuardWire but increased steadily with vessel size with the FilterWire EX. In the smallest tertile, MACEs were reduced by 71% with the FilterWire EX compared with the GuardWire (p = 0.05), with the devices showing similar event rates in the other tertiles.
authors.affiliation: University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA.
authors.forename: Aravind
authors.initials: A
authors.lastname: Swaminathan
authors.forename: Gregg W
authors.initials: GW
authors.lastname: Stone
authors.forename: Campbell
authors.initials: C
authors.lastname: Rogers
authors.forename: James
authors.initials: J
authors.lastname: Hermiller
authors.forename: Robert
authors.initials: R
authors.lastname: Feldman
authors.forename: Patrick
authors.initials: P
authors.lastname: Hall
authors.forename: Robert
authors.initials: R
authors.lastname: Haber
authors.forename: A R Zaki
authors.initials: AR
authors.lastname: Masud
authors.forename: Patrick
authors.initials: P
authors.lastname: Cambier
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Caputo
authors.forename: David A
authors.initials: DA
authors.lastname: Cox
authors.forename: Roxana
authors.initials: R
authors.lastname: Mehran
authors.forename: Howard C
authors.initials: HC
authors.lastname: Herrmann
mesh_terms: D000368:Aged; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation; D002404:Catheterization / Q000295:instrumentation* / Q000379:methods; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D004617:Embolism / Q000517:prevention & control*; D005260:Female; D005374:Filtration / Q000295:instrumentation; D006801:Humans; D008297:Male; D012501:Saphenous Vein / Q000033:anatomy & histology* / Q000637:transplantation*; D015607:Stents; D016896:Treatment Outcome