Identification of HLA-B*5136 in the Chinese population.
We report here a new HLA-B*5136 allele identified by sequence-based typing in the Chinese population. The new B*5136 allele showed four nucleotides difference with B*5108 at exon 3, which are two point mutations at nucleotide positions 527 T-->A and 583 C-->T, and two substitutions at adjacent nucleotide positions 559 C-->A and 560 T-->C. This results in three amino acid changes from Val to Glu at codon 177, Leu to Thr at codon 187, and His to Tyr at codon 195.
Yan
L-X
LX
HLA typing laboratory, Blood Center of Zhejiang Province, Hangzhou, Zhejiang Province, China. ylx@zjb.org.cn
Zhu
F-M
FM
Lv
Q-F
QF
Zhang
W
W
Zhang
H-Q
HQ
He
J
J
D000483:Alleles; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D002681:China; D005091:Exons; D005820:Genetic Testing; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
D015235:HLA-B Antigens