PEG-grafted chitosan as an injectable thermoreversible hydrogel.
PEG-grafted chitosan was formulated such that its solution undergoes a thermally reversed phase transition from an injectable free-flowing solution at low temperature to a gel at body temperature. Aqueous solutions of PEG-grafted chitosan can be prepared at physiological pH values, thereby allowing safe incorporation of bioactive molecules. This injectable thermoreversible hydrogel is potentially suitable for a wide range of biomedical applications, particularly in sustained in vivo drug release and tissue engineering. An aqueous solution of PEG-grafted chitosan polymer is injectable at low temperatures but forms a gel at body temperature.
Bhattarai
Narayan
N
Department of Materials Science & Engineering, University of Washington, Seattle, WA 98195-2120, USA.
Matsen
Frederick A
FA
Zhang
Miqin
M
D048271:Chitosan; D020100:Hydrogels; D009682:Magnetic Resonance Spectroscopy; D011092:Polyethylene Glycols; D013696:Temperature; D014783:Viscosity
D020100:Hydrogels; D011092:Polyethylene Glycols; D048271:Chitosan