title: Determinants of salivary cortisol levels in 10-12 year old children; a population-based study of individual differences.
abstract: The hypothalamic-pituitary-adrenal (HPA)-axis is a central component of the body's neuroendocrine response to stress. Its major end-product cortisol has profound effects on mood and behavior. Although it has often been suggested, it remains unknown whether differences in HPA-axis physiology are part of an individual's vulnerability to psychopathology, and constitute a causal factor in its development. In order to study the contribution of HPA-axis physiology to the development of psychopathology, we measured HPA-axis physiology in a community-cohort of 1768 10-12 year-old children. The aims of the here presented study were twofold: (1) to obtain data on HPA-axis function in a large cohort of pre- and early-adolescent children, both in terms of total hormonal output and in terms of the dynamics of cortisol secretion (by means of the cortisol awakening response); and (2) to study potential confounders of the cortisol-psychopathology relationship in this age group, such as season of sampling, age, gender, pubertal development, perinatal variables and BMI. We found a wide interindividual variability in HPA-axis function. An increase in cortisol in the first 30 min after awakening was present in 70.7% of children, but the increase appears lower in children than in adults. In addition, this study suggests that season of sampling and gender may act as potential confounders in the cortisol-psychopathology relationship. We will follow these children longitudinally for the development of psychopathology in the period from childhood into adulthood. This period covers adolescence, which is a critical time for the appearance and development of psychiatric disorders.
authors.affiliation: Department of Psychiatry and Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen Medical Center, P.O. Box 30 001, 9700 RB Groningen, The Netherlands. j.g.m.rosmalen@med.rug.nl
authors.forename: J G M
authors.initials: JG
authors.lastname: Rosmalen
authors.forename: A J
authors.initials: AJ
authors.lastname: Oldehinkel
authors.forename: J
authors.initials: J
authors.lastname: Ormel
authors.forename: A F
authors.initials: AF
authors.lastname: de Winter
authors.forename: J K
authors.initials: JK
authors.lastname: Buitelaar
authors.forename: F C
authors.initials: FC
authors.lastname: Verhulst
mesh_terms: D000375:Aging / Q000502:physiology; D019540:Area Under Curve; D001724:Birth Weight / Q000502:physiology; D001823:Body Composition / Q000502:physiology; D002648:Child; D002940:Circadian Rhythm; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D007206:Individuality; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D009483:Neuropsychological Tests; D011153:Population; D011247:Pregnancy; D011627:Puberty / Q000502:physiology; D012016:Reference Values; D012463:Saliva / Q000378:metabolism*; D012621:Seasons; D012727:Sex Characteristics
chemical_list: D006854:Hydrocortisone