Antioxidant activity of propofol and related monomeric and dimeric compounds.
This study was carried out to investigate the antioxidant activity of propofol (2,6-diisopropylphenol) and its related compounds, butylated hydroxyanisole (BHA), 2,6-dimethylphenol, 2,6-di-t-butylphenol, and their dimeric compounds. The degree of antioxidant activity was evaluated based on the degree of peroxidation induced with Fe-ascorbic acid in egg phosphatidylcholine through the determination of thiobarbituric acid-reactive substances (TBARS) formed during peroxidation. Their antioxidant activities were in the order of dipropofol>di(2,6-di-t-butylphenol)>diBHA>di(2,6-dimethylphenol). Dipropofol, a dimeric compound of propofol, showed the highest antioxidant activities. Dimeric compounds had higher activities than monomeric compounds, and the 1,1-diphenyl-p-picryhydrazyl-trapping ability of dimeric compounds was also greater than those of monomeric compounds (4-10-fold). These results suggest that dimeric phenols may increase their antioxidant activities along with increments in the conjugation system and play a inhibitory role in the propagation of free radical chain reactions.
Ogata
Masahiro
M
Kyoritsu University of Pharmacy, Tokyo, Japan. ogata-ms@za.pial.jp
Shin-Ya
Kazuo
K
Urano
Shiro
S
Endo
Toyoshige
T
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D015227:Lipid Peroxidation; D010636:Phenols / Q000494:pharmacology*; D015742:Propofol / Q000494:pharmacology*; D014992:Xylenes / Q000494:pharmacology*
D000975:Antioxidants; D016166:Free Radical Scavengers; D010636:Phenols; D014992:Xylenes; C035407:2,6-di-tert-butylphenol; C036531:2,6-xylenol; D015742:Propofol