title: Normal-phase HPLC enantioseparation of novel chiral metal tetrahedrane-type clusters on an amylose-based chiral stationary phase.
abstract: In the present work, an amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral stationary phase (CSP) was prepared by coating ADMPC on small-particle silica gel. This ADMPC-CSP was for the first time successfully applied to separate a series of novel chiral metal tetrahedrane-type clusters. Furthermore, the influence of a mobile-phase modifier (various alcohols added in the mobile phase), including its concentration and structure, and the structures of the clusters on the chiral separation and retention was investigated. The results suggest that not only the structure and concentration of alcohol in the mobile phase, but also the subtle structural differences in racemate can have a pronounced effect on the enantiomeric separation and retention.
authors.affiliation: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 342 Tianshui Road, Lanzhou 730000, People's Republic of China.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Wen-Zhi
authors.initials: WZ
authors.lastname: Li
authors.forename: Quan-Yi
authors.initials: QY
authors.lastname: Zhao
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Li
authors.forename: Li-Ren
authors.initials: LR
authors.lastname: Chen