title: Pharmacokinetics of subcutaneous selenium in adult llamas.
abstract: Selenium (Se) deficiency disease has been described in camelids and only clinical data is available for administration of parenteral Se supplements. This study investigated the pharmacokinetic effects of subcutaneous Se injection (0.1 mg/kg) in llamas fed a diet adequate in Se. Absorption of Se was rapid with peak whole blood Se concentration at the first sampling time. Significant differences in whole blood Se concentration from before injection of Se were not found past 2 days after Se injection. Parenteral Se is unlikely to have a long-term effect on whole blood Se concentration in llamas fed adequate dietary Se.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL, 36849, USA.
authors.forename: Bryan M
authors.initials: BM
authors.lastname: Waldridge
authors.forename: Sue H
authors.initials: SH
authors.lastname: Duran
authors.forename: William R
authors.initials: WR
authors.lastname: Ravis
authors.forename: Ralph
authors.initials: R
authors.lastname: Paxton
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Herdt
authors.forename: David G
authors.initials: DG
authors.lastname: Pugh
mesh_terms: D000042:Absorption; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D002161:Camelids, New World / Q000378:metabolism*; D004032:Diet; D019587:Dietary Supplements; D006207:Half-Life; D007263:Infusions, Parenteral / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D008297:Male; D012643:Selenium / Q000008:administration & dosage / Q000097:blood / Q000172:deficiency / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D000975:Antioxidants; D012643:Selenium