title: [Enhanced absorption of breviscapine photosomes in small intestine of rats].
abstract: OBJECTIVE
  To investigate whether the absorption of breviscapine can be enhanced by using breviscapine photosomes.
  
  
  METHODS
  Testing the uptake and intestinal permeability of breviscapine powder and breviscapine photosomes by using intestine perfusion technique and reverted gut sac method.
  
  
  RESULTS
  The uptake and permeability coefficient of breviscapine were increased in photosomes. The absorption process obeyed the Fick's law in the range of 0-100 microg x mL(-1).
  
  
  CONCLUSIONS
  The absorption breviscapine photosomes is enhanced by increasing the permeability through a passive mechanism.
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
authors.forename: Xiao-qiao
authors.initials: XQ
authors.lastname: Tang
authors.forename: Xiang-liang
authors.initials: XL
authors.lastname: Yang
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry; D004337:Drug Carriers; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004337:Drug Carriers; D005419:Flavonoids; D010743:Phospholipids; C061097:breviscapine