title: [Protective effects of polysacchride of Spirulina platensis and Sargassum thunbeergii on vascular of alloxan induced diabetic rats].
abstract: OBJECTIVE
  To study the protective effects of polysaccharide of Spirulina platensis and Sargassum thunbeergii on vascular of alloxan (ALX) induced diabetic rats.
  
  
  METHODS
  With the doses of polysaccharide of Spirulina platensis (PSP) and Sargassum thunbeergii (PST) compound (1:1) 12.261, 36.783, 110.349 mg x kg(-1) by i.g. administration to alloxan induced diabetic rats respectively for 6 weeks. Then the blood glucose and the TC, HDL-C, TG, NO, ET in serum were detected. The contraction and relaxation response to NE and ACh in aortic rings of the alloxan induced diabetic rats has been studied.
  
  
  RESULTS
  The results showed the compound of PSP and PST could decrease the blood glucose and the TC, TG, NO, ET in serum and increase HDL-C than in the alloxan induced diabetic rats. The contraction responses to NE in aortic rings of the alloxan induced diabetic rats were significantly elevated in the normal rats, and the responses to ACh were significantly lower. PSP and PST compound could significantly lower the responses to NE and significantly elevate the responses to ACh in aortic rings of the alloxan induced diabetic rats.
  
  
  CONCLUSIONS
  PSP and PST compound could decrease blood glucose and could protect the vascular of alloxan induced diabetic rats.
authors.affiliation: School of Pharmaceutical Sciences, SunYat-sen University, Guangzhou 510275, China.
authors.forename: Zhi-xuan
authors.initials: ZX
authors.lastname: Huang
authors.forename: Xue-ting
authors.initials: XT
authors.lastname: Mei
authors.forename: Dong-hui
authors.initials: DH
authors.lastname: Xu
authors.forename: Shi-bo
authors.initials: SB
authors.lastname: Xu
authors.forename: Jun-yi
authors.initials: JY
authors.lastname: Lv
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D000458:Cyanobacteria / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D016232:Endothelins / Q000097:blood; D005260:Female; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009569:Nitric Oxide / Q000097:blood; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D044647:Sargassum / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D016232:Endothelins; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; D020011:Protective Agents; D014280:Triglycerides; D009569:Nitric Oxide; D002784:Cholesterol