title: Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia.
abstract: We investigated the significance of the platelet indices, mean platelet volume (MPV), platelet size deviation width (PDW), and platelet-large cell ratio (P-LCR), in the diagnosis of thrombocytopenia by comparing these levels in 40 patients with hypo-productive thrombocytopenia (aplastic anaemia; AA) and 39 patients with hyper-destructive thrombocytopenia (immune thrombo-cytopenia; ITP). The sensitivity and specificity of platelet indices to make a diagnosis of ITP were also compared. All platelet indices were significantly higher in ITP than in AA, and platelet indices showed sufficient sensitivity and specificity. The area under the curve (AUC) of the receiver operating characteristics curve of platelet indices was large enough to enable the diagnosis of ITP. P-LCR and PDW had the largest AUCs, which indicated that these values were very reliable for immune thrombocytopenia. Our results suggest that these indices provide clinical information about the underlying conditions of thrombocytopenia. More attention should be paid to these indices in the diagnosis of thrombocytopenia.
authors.affiliation: Central Clinical Laboratory, Jikei University Hospital, Tokyo 105-8471, Japan. ken.kaito@jikei.ac.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Kaito
authors.forename: Hiroko
authors.initials: H
authors.lastname: Otsubo
authors.forename: Noriko
authors.initials: N
authors.lastname: Usui
authors.forename: Miyuki
authors.initials: M
authors.lastname: Yoshida
authors.forename: Jyunko
authors.initials: J
authors.lastname: Tanno
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kurihara
authors.forename: Kozue
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Hirata
authors.forename: Kenichi
authors.initials: K
authors.lastname: Domitsu
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000741:Anemia, Aplastic / Q000097:blood; D019540:Area Under Curve; D001792:Blood Platelets / Q000473:pathology*; D048429:Cell Size; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis*; D012372:ROC Curve; D012680:Sensitivity and Specificity