title: [Diagnosis of septic loosening of hip prosthesis with LeukoScan. SPECT scan with 99mTc-labeled monoclonal antibodies].
abstract: Diagnosis of septic loosening of hip endoprosthesis with antigranulocyte scintigraphy (AGS) was analysed. Twenty-one hip prostheses were studied using laboratory tests and, in cases of elevated values, three-phase bone scan (BS) and AGS. Elective SPECT/CT scans were performed. Histologic and microbiologic exams verified the diagnosis. The AGS analysis revealed sensitivity, specificity and accuracy of value 1, while positive and negative predictive values were also 1. BS showed sensitivity of 1 and specificity of 0.33. In three cases, SPECT/CT scans corroborated the AGS interpretation. This diagnostic algorithm proved effective in the detection of septic loosening of hip prostheses. AGS can be avoided without risk of infection being overlooked.
authors.affiliation: Orthopädische Klinik, Universitätsklinikum, Patras, Griechenland. ariskaisidis@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Kaisidis
authors.forename: P
authors.initials: P
authors.lastname: Megas
authors.forename: D
authors.initials: D
authors.lastname: Apostolopoulos
authors.forename: T
authors.initials: T
authors.lastname: Spiridonidis
authors.forename: D
authors.initials: D
authors.lastname: Koumoundourou
authors.forename: P
authors.initials: P
authors.lastname: Zouboulis
authors.forename: E
authors.initials: E
authors.lastname: Lambiris
authors.forename: P
authors.initials: P
authors.lastname: Vassilakos
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007593:Joint Instability / Q000000981:diagnostic imaging* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging* / Q000209:etiology*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D019275:Radiopharmaceuticals; C101172:Sulesomab; D013667:Technetium
references.citation: Eur J Nucl Med. 1995 Oct;22(10 ):1195-211
references.pmid: 8542906
references.citation: Int J Cancer. 1993 Sep 9;55(2):262-8
references.pmid: 7690347
references.citation: J Bone Joint Surg Am. 1999 May;81(5):672-83
references.pmid: 10360695
references.citation: Z Orthop Ihre Grenzgeb. 2003 Sep-Oct;141(5):547-53
references.pmid: 14551841
references.citation: Tumour Biol. 1995;16(1):17-22
references.pmid: 7863218
references.citation: Clin Infect Dis. 1998 Nov;27(5):1247-54
references.pmid: 9827278
references.citation: Am J Infect Control. 1999 Apr;27(2):97-132; quiz 133-4; discussion 96
references.pmid: 10196487
references.citation: J Clin Microbiol. 1998 Oct;36(10):2932-9
references.pmid: 9738046
references.citation: Instr Course Lect. 1998;47:285-95
references.pmid: 9571430
references.citation: J Clin Pathol. 1999 Feb;52(2):118-23
references.pmid: 10396239
references.citation: Clin Infect Dis. 2001 Sep 1;33 Suppl 2:S94-106
references.pmid: 11486305
references.citation: Instr Course Lect. 1999;48:111-22
references.pmid: 10098033
references.citation: Clin Orthop Relat Res. 1976 Jun;(117):221-40
references.pmid: 776484
references.citation: Eur J Nucl Med. 1990;16(8-10):649-55
references.pmid: 2116969
references.citation: J Nucl Med. 1992 Apr;33(4):13N-14N, 27N
references.pmid: 1552325
references.citation: J Nucl Med. 1994 Sep;35(9):1436-43
references.pmid: 8071688
references.citation: J Nucl Med. 1990 Apr;31(4):403-12
references.pmid: 2324817
references.citation: J Bone Joint Surg Am. 1969 Jun;51(4):737-55
references.pmid: 5783851
references.citation: Radiology. 1989 Apr;171(1):141-6
references.pmid: 2928518
references.citation: J Nucl Med. 1992 May;33(5):803-14
references.pmid: 1569493
references.citation: Cancer. 1993 Jun 1;71(11):3478-85
references.pmid: 7683969
references.citation: Z Orthop Ihre Grenzgeb. 2001 Sep-Oct;139(5):415-9
references.pmid: 11605293
references.citation: Clin Orthop Relat Res. 1996 Aug;(329):263-72
references.pmid: 8769461
references.citation: J Nucl Med. 1998 Jan;39(1):34-42
references.pmid: 9443735
references.citation: Lancet. 1986 Oct 25;2(8513):946-9
references.pmid: 2877132
references.citation: Clin Orthop Relat Res. 1997 Feb;(335):275-85
references.pmid: 9020229