Diffuse diabetic macular oedema treated by intravitreal triamcinolone acetonide: a comparative, non-randomised study.
OBJECTIVE
To report on visual outcome of patients receiving an intravitreal injection of triamcinolone acetonide for treatment of diffuse diabetic macular oedema.


METHODS
Prospective, comparative, non-randomised clinical interventional study included 136 patients with diffuse diabetic macular oedema. Patients of the study group (97 eyes) received an intravitreal injection of 20-25 mg of triamcinolone acetonide and no other retinal treatment. Patients of the control group (69 eyes) received focal or panretinal laser treatment if indicated. Mean (standard deviation) follow up was 8.4 (SD 6.0) months (range 1.03-25.2 months).


RESULTS
Visual acuity (VA) increased significantly (p<0.001) in the study group with 66 (68%) eyes gaining in VA by at least two Snellen lines. In the control group, VA did not change significantly during the first 4 months of follow up, and decreased significantly (p<0.001) towards the end of the follow up. Difference in change of best VA was significant (p<0.001) between both groups. Correspondingly, the number of patients with VA improvement of two or more Snellen lines and visual loss of two or more Snellen lines, respectively, was significantly (p<0.001) higher and lower, respectively, in the study group.


CONCLUSIONS
Intravitreal triamcinolone acetonide can temporarily increase VA in some patients with diffuse diabetic macular oedema.
Jonas
J B
JB
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the University of Heidelberg, Heidelberg, Germany. Jost.Jonas@ma.augen.uni-heidelberg.de
Akkoyun
I
I
Kreissig
I
I
Degenring
R F
RF
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016009:Chi-Square Distribution; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D053685:Laser Therapy; D008268:Macular Degeneration / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000627:therapeutic use; D014792:Visual Acuity; D014822:Vitreous Body
D000893:Anti-Inflammatory Agents; D014222:Triamcinolone Acetonide
Ophthalmology. 1991 May;98(5 Suppl):807-22
2062514
Eur J Ophthalmol. 2003 Jul;13(6):575-6
12948317
Am J Ophthalmol. 2003 Feb;135(2):246-9
12566041
J Glaucoma. 2001 Aug;10(4):284-7
11558812
Am J Ophthalmol. 2001 Sep;132(3):425-7
11530068
J Cataract Refract Surg. 2002 Nov;28(11):2040-1
12457682
Arch Ophthalmol. 2001 Sep;119(9):1380-3
11545651
Br J Ophthalmol. 2003 Apr;87(4):462-8
12642311
Eur J Ophthalmol. 2003 Jun;13(5):468-73
12841570
Ophthalmology. 1992 May;99(5):753-9
1594222
Retina. 2000;20(5):554-5
11039438
Arch Ophthalmol. 2003 May;121(5):729-30
12742856
Retina. 2003 Feb;23(1):113-6
12652245
Br J Ophthalmol. 2003 Mar;87(3):361
12598455
Br J Ophthalmol. 2003 Jan;87(1):24-7
12488256
Am J Ophthalmol. 2004 Feb;137(2):367-8
14962439
Arch Ophthalmol. 2004 Feb;122(2):218-22
14769599
Br J Ophthalmol. 2002 Feb;86(2):247-8
11815359
Graefes Arch Clin Exp Ophthalmol. 2002 Oct;240(10):873-4
12530461
Ophthalmology. 2002 May;109(5):920-7
11986098
Am J Ophthalmol. 2003 Aug;136(2):384-6
12888077
Aust N Z J Ophthalmol. 1999 Dec;27(6):431-2
10641903
Retina. 2000;20(3):244-50
10872928
J Cataract Refract Surg. 2003 Jan;29(1):27-33
12551663
Arch Ophthalmol. 2003 Jan;121(1):57-61
12523885
Ophthalmology. 2001 Apr;108(4):765-72
11297495
Aust N Z J Ophthalmol. 1995 Nov;23(4):293-8
11980075
Ophthalmology. 2000 Nov;107(11):2024-33
11054326
Ophthalmology. 1991 May;98(5 Suppl):741-56
2062510
Graefes Arch Clin Exp Ophthalmol. 2002 Sep;240(9):782-3
12271378
Am J Ophthalmol. 2001 Apr;131(4):468-71
11292410
Br J Ophthalmol. 2002 May;86(5):527-9
11973247
Arch Ophthalmol. 2003 May;121(5):667-73
12742844
Graefes Arch Clin Exp Ophthalmol. 2001 Jul;239(6):464-5
11561798
Br J Ophthalmol. 2005 Jan;89(1):122
15615762
Ophthalmology. 2004 Feb;111(2):218-24; discussion 224-5
15019365
Clin Exp Ophthalmol. 2001 Feb;29(1):2-6
11272779