Atypical onset of antiphospholipid syndrome in pregnancy: a case report.
BACKGROUND
We present a case of an atypical onset of antiphospholipid syndrome (APS).


METHODS
A woman in her 15th week gestation had a thrombosis of an unknown cerebral cavernoma, which was successfully removed. Twenty-six days after, she was admitted for a severe pain in right hypochondrium and a second class HELLP syndrome was diagnosed. Two days after, she had a fetal loss. After 1 month, laboratory tests revealed high level of antiphospholipid antibodies. At the same time, she developed a spontaneous thrombosis at her right arm. After 6 weeks, antiphospholipid antibodies, tested again, result positive.


CONCLUSIONS
Antiphospholipid antibodies often cause pregnancy complications, but, to our knowledge, this is the first report of an association of antiphospholipid antibodies, with cerebral cavernoma thrombosis and early onset HELLP syndrome.
Riviello
C
C
Department of Gynaecology, Perinatology and Human Reproduction, Viale Morgagni 85 50134 Florence, Italy.
Ammannati
F
F
Lamassa
M
M
Mariotti
F
F
Mennonna
P
P
Parretti
E
E
Tondi
F
F
Mello
G
G
D000022:Abortion, Spontaneous; D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D005260:Female; D017359:HELLP Syndrome / Q000150:complications / Q000175:diagnosis; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood; D011379:Prognosis; D012307:Risk Factors; D013927:Thrombosis / Q000150:complications / Q000175:diagnosis
D017152:Antibodies, Antiphospholipid