Development of conjugated linoleic acid (CLA)-mediated lipoatrophic syndrome in the mouse.
Conjugated linoleic acids (CLA) are positional and geometric dienoic isomers of linoleic acid. Dietary CLA supplementation leads to a drop in fat mass in various species, including in humans. The t10,c12-CLA isomer is responsible for this anti-obesity effect. The reduction of fat mass is especially dramatic in the mouse, in which it is associated with severe hyperinsulinemia, insulin resistance and massive liver steatosis. The origin of these adverse side effects and putative chronology of events leading to CLA-mediated lipoatrophic syndrome are presented and discussed in this review.
Poirier
H
H
Physiologie de la Nutrition, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation (ENSBANA), UMR 5170 CNRS-CESG/1214INRA/Université de Bourgogne, F-21000 Dijon, France.
Niot
I
I
Clément
L
L
Guerre-Millo
M
M
Besnard
P
P
D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D003923:Diabetes Mellitus, Lipoatrophic / Q000209:etiology*; D004041:Dietary Fats / Q000494:pharmacology*; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000139:chemically induced; D007333:Insulin Resistance / Q000502:physiology; D007515:Islets of Langerhans / Q000187:drug effects; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology / Q000502:physiology*; D051379:Mice
D004041:Dietary Fats; D044243:Linoleic Acids, Conjugated