Given capsule endoscopy in celiac disease: evaluation of diagnostic accuracy and interobserver agreement.
OBJECTIVE
Capsule endoscopy (CE) has been increasingly used for diagnosing diseases of the small bowel. It is an attractive technique for assessing celiac disease (CD) because it is noninvasive and provides a close and magnified view of the mucosa of the entire small bowel. In this study, we evaluated the accuracy of CE and interobserver agreement in recognizing villous atrophy (VA) using histopathology as the reference. We also explored the extent of small bowel involvement with CD and the relationship between the length of the affected bowel and the clinical presentation.


METHODS
Ten CD patients with histologically proven VA and the same number of controls were subjected to CE. Four, blinded to histology findings, investigators (two with and two without prestudy CE experience) were asked to diagnose VA on CE images.


RESULTS
Based on assessment of all four investigators, the overall sensitivity, specificity, PPV, and NPV of CE in diagnosing VA were 70%, 100%, 100%, and 77%, respectively. The sensitivity and the specificity of the test was 100% when the reports of experienced capsule endoscopists only were analyzed. The interobserver agreement was perfect (kappa= 1.0) between investigators with prestudy CE experience and poor (kappa= 0.2) between the investigators who had limited prestudy exposure to CE. Celiac patients with extensive small bowel involvement had typical symptoms of malabsorption (diarrhea, weight loss) as opposed to mild and nonspecific symptoms in patients whose disease was limited to the proximal small bowel. CE was tolerated well by all study participants with 95% reporting absence of any discomfort.


CONCLUSIONS
Although based on a small sample size, the study suggests that CE may be useful in assessing patients with CD. Familiarity with CE technology appears to be a critical factor affecting the accuracy of the test. Larger studies are warranted to more precisely define the advantages and limitations of CE in CD.
Petroniene
Rima
R
Division of Gastroenterology and Pathology, St. Michael's Hospital, 30 Bond Street, Toronto, ON, Canada.
Dubcenco
Elena
E
Baker
Jeffrey P
JP
Ottaway
Clifford A
CA
Tang
Shou-Jiang
SJ
Zanati
Simon A
SA
Streutker
Cathy J
CJ
Gardiner
Geoffrey W
GW
Warren
Ralph E
RE
Jeejeebhoy
Khursheed N
KN
D001284:Atrophy; D002446:Celiac Disease / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal / Q000379:methods* / Q000592:standards; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D015588:Observer Variation; D012680:Sensitivity and Specificity