title: Phenolic constituents from Ephedra nebrodensis.
abstract: Two new phenolic glycosides, 4-hydroxy-3-(3-methyl-2-butenyl)phenyl beta-D-glucopyranoside (nebrodenside A) and O-coumaric acid beta-D-allopyranoside (nebrodenside B), were isolated from the aerial parts of Ephedra nebrodensis. In addition, O-coumaric acid glucoside, (-)-epicatechin, and (-)-ephedrine were also isolated. The structures were deduced from extensive 1D and 2DNMR spectroscopy (1H, 13C, DQF-COSY, TOCSY, GHSQC, GHMQC, ROESY) as well as mass spectrometry (EI and HR-MALDI). (-)-Epicatechin showed weak antiviral activity against Influenza A virus and very weak cytotoxicity against MDCK cells.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Faculty of Pharmacy, University of Cagliari, Via Ospedale 72, Cagliari 09124, Italy. cottiglf@unica.it
authors.forename: Filippo
authors.initials: F
authors.lastname: Cottiglia
authors.forename: Leonardo
authors.initials: L
authors.lastname: Bonsignore
authors.forename: Laura
authors.initials: L
authors.lastname: Casu
authors.forename: Delia
authors.initials: D
authors.lastname: Deidda
authors.forename: Rafaello
authors.initials: R
authors.lastname: Pompei
authors.forename: Mariano
authors.initials: M
authors.lastname: Casu
authors.forename: Costantino
authors.initials: C
authors.lastname: Floris
mesh_terms: D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029789:Ephedra / Q000737:chemistry*; D004809:Ephedrine / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009980:Influenza A virus / Q000187:drug effects
chemical_list: C497298:4-hydroxy-3-(3-methyl-2-butenyl)phenyl beta-D-glucopyranoside; D003374:Coumarins; D006027:Glycosides; C497297:O-coumaric acid beta-D-allopyranoside; D002392:Catechin; D004809:Ephedrine