[Research progress on the oral solid rapidly disintegrating dosage form].
Oral solid rapidly-disintegrating dosage form has aroused general concern increasingly because of its characteristics about convenient taking, rapid absorption, high bioavailability and not serious adverse drug reaction. This article introduced its mechanism, which was rapid disintegration, fast dissolution or the promoting dissolving action of supplementary material. This dosage form included dispersible tablets, fast dissolving tablets, fast releasing tablets, droppills, granules and tablets by solid dispersible technology, quick-liquefying chewable tablets and dry elixir. It will become a new way for promoting bioavailability in traditional Chinese medicine difficultly-dissolving composition, create up a new dosage form for treating emergency case by traditional Chinese medicine and give a new thinking for studying new supplementary materials. In brief, oral solid rapidly-disintegrating dosage form will have good prospect in the field of traditional Chinese medicine.
Shen
Lan
L
Shanghai University of Traditional Chinese Medicine, Shanghai 201203.
Lin
Xiao
X
Xu
De-sheng
DS
Feng
Yi
Y
D000284:Administration, Oral; D002214:Capsules / Q000737:chemistry*; D002482:Cellulose; D016503:Drug Delivery Systems; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D011092:Polyethylene Glycols; D016062:Porosity; D011205:Povidone; D012995:Solubility; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*
D002214:Capsules; D004365:Drugs, Chinese Herbal; D013607:Tablets; D011092:Polyethylene Glycols; D002482:Cellulose; D011205:Povidone; C109691:microcrystalline cellulose