title: Norepinephrine transporter (NET) promoter and 5'-UTR polymorphisms: association analysis in panic disorder.
abstract: Several biochemical and pharmacological studies suggest that the catecholaminergic system involving the norepinephrine transporter (NET) is relevant for the pathogenesis of panic disorder. Three single nucleotide polymorphisms in the promoter or untranslated 5' region of the NET gene were investigated by means of RFLP analysis in a sample of 115 German patients with panic disorder and 115 matched controls. Statistical analysis failed to show association with the overall diagnosis of panic disorder. In the subgroup of patients with panic disorder without agoraphobia, however, two polymorphisms were found to be associated with the disease (G/C (rs2397771): p < 0.05; T/C (rs2242446): p < 0.01). While our data do not support a major function of the NET gene in the development of panic disorder, it may play a role in the subgroup of panic disorder without agoraphobia.
authors.affiliation: Department of Psychiatry, University of Münster, Albert-Schweitzer-Str. 11, D-48149 Münster, Germany.
authors.forename: Yoo J
authors.initials: YJ
authors.lastname: Lee
authors.forename: Christa
authors.initials: C
authors.lastname: Hohoff
authors.forename: Katharina
authors.initials: K
authors.lastname: Domschke
authors.forename: Philipp
authors.initials: P
authors.lastname: Sand
authors.forename: Gregor
authors.initials: G
authors.lastname: Kuhlenbäumer
authors.forename: Anja
authors.initials: A
authors.lastname: Schirmacher
authors.forename: Christine M
authors.initials: CM
authors.lastname: Freitag
authors.forename: Jobst
authors.initials: J
authors.lastname: Meyer
authors.forename: Gerald
authors.initials: G
authors.lastname: Stöber
authors.forename: Petra
authors.initials: P
authors.lastname: Franke
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Jürgen
authors.initials: J
authors.lastname: Fritze
authors.forename: Rolf
authors.initials: R
authors.lastname: Fimmers
authors.forename: Henk S
authors.initials: HS
authors.lastname: Garritsen
authors.forename: Florian
authors.initials: F
authors.lastname: Stögbauer
authors.forename: Jürgen
authors.initials: J
authors.lastname: Deckert
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics*; D000328:Adult; D000379:Agoraphobia / Q000235:genetics; D000483:Alleles; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050484:Norepinephrine Plasma Membrane Transport Proteins; D016584:Panic Disorder / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D027981:Symporters / Q000235:genetics*
chemical_list: D020121:5' Untranslated Regions; D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human; D027981:Symporters