title: Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal?
abstract: The anti-double-stranded DNA (anti-dsDNA) antibody test incorporated in the 1982 revised American College of Rheumatology criteria for the classification of systemic lupus erythematosus needs updating to reflect current insights and technical achievements, including allowance for the presence of nonpathogenic anti-dsDNA antibodies. As we need to develop at least some measure of pathogenicity of anti-dsDNA antibodies, we propose that initial anti-dsDNA antibody screening is done by sensitive ELISA and supplemented by more stringent assays. Simultaneously the relevance of anti-dsDNA antibody presence needs to be restricted to clinical manifestations, thought to be caused by anti-dsDNA antibody and within an appropriate time frame.
authors.affiliation: Department of Rheumatology, Institute of Clinical Medicine, University of Tromsø, Norway. hans.nossent@unn.no
authors.forename: Hans C
authors.initials: HC
authors.lastname: Nossent
authors.forename: Ole Petter
authors.initials: OP
authors.lastname: Rekvig
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood* / Q000276:immunology; D000937:Antigen-Antibody Reactions; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000145:classification / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D016000:Cluster Analysis; D015331:Cohort Studies; D003095:Collagen Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D004247:DNA / Q000276:immunology*; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D006040:Goals; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000145:classification / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D015337:Multicenter Studies as Topic; D012015:Reference Standards; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D000974:Antibodies, Antinuclear; D001324:Autoantigens; D004247:DNA
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