[Anti-phosphatidylserine-prothrombin antibody in patients with recurrent abortion and preeclampsia].
OBJECTIVE
The aim of the study was to describe the frequency of anti-phosphatidylserine-prothrombin antibody(aPS/PTAb) in patients with recurrent abortion and preeclampsia, and to study the relationship between the presence of aPS/PTAb and clinical finding. Eighty six cases of recurrent abortion and 82 cases of preeclampsia were studied. A aPS/PTAb was measured by an enzyme linked immunosorbent assay (ELISA).


RESULTS
In patients with recurrent abortion, 3 out of 86 cases(3.4%) were positive in IgG antibody measurements and 5 out of 86(5.8%) were positive in IgM antibody measurements. In patients with preeclampsia, 2 out of 82 cases(2.5%) were positive in IgG antibody measurements and 13 out of 82(16%) were positive in IgM antibody measurements. The positive rates of aPS/PTAb in severe hypertension-positive cases is greater than in hypertension-negative cases(p=0.045). The positive rates of aPS/PTAb is higher tendency with in severe type than in mild type(p=0.117). The positive rates of aPS/PTAb is higher tendency with proteinuria and/or hypertension than without proteinuria(p=0.098) or hypertension(p=0.096).


CONCLUSIONS
We found that aPS/PTAb appears in some cases of patients with recurrent abortion and preeclampsia. Our data suggest that aPS/PTAb might be a risk factor in patients with recurrent abortion, and may relate to clinical finding in preeclampsia.
Mitsui
Mari
M
Department of Obstetrics and Gynecology, Nihon University School of Medicine, Japan.
Yamashiro
Miwako
M
Yamamoto
Tatsuo
T
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D010718:Phosphatidylserines / Q000276:immunology*; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D011516:Prothrombin / Q000276:immunology*; D012307:Risk Factors
D001323:Autoantibodies; D010718:Phosphatidylserines; D011516:Prothrombin