title: Neosporosis in a young dog presenting with dermatitis and neuromuscular signs.
abstract: A 16-week-old, male boxer dog developed multifocal nodular dermatitis followed by rapidly progressive and fatal neuromuscular disease. Protozoal tachyzoites were demonstrated by aspiration and biopsy of dermal lesions. Necropsy and histology revealed necrotising inflammation associated with intralesional protozoal organisms in various organs including the brain, heart, skeletal muscle and skin. Serology suggested active infection with Neospora caninum. Immunohistochemistry provided a definitive diagnosis. Dermatitis is a finding rarely associated with juvenile neosporosis. The possible role of immunosuppression is discussed.
authors.affiliation: Department of Pathology and Infectious Disease, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire.
authors.forename: S P
authors.initials: SP
authors.lastname: Boyd
authors.forename: P A
authors.initials: PA
authors.lastname: Barr
authors.forename: H W
authors.initials: HW
authors.lastname: Brooks
authors.forename: J P
authors.initials: JP
authors.lastname: Orr
mesh_terms: D000818:Animals; D003048:Coccidiosis / Q000175:diagnosis / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D007150:Immunohistochemistry; D008297:Male; D018688:Neospora; D009468:Neuromuscular Diseases / Q000175:diagnosis / Q000662:veterinary*; D012876:Skin Diseases, Parasitic / Q000175:diagnosis / Q000662:veterinary*