Anasarca edema with amlodipine treatment.
OBJECTIVE
To report a case of anasarca edema associated with amlodipine use.


METHODS
A 77-year-old woman with essential hypertension who had not been treated with any other drug was prescribed amlodipine 10 mg/day to control her blood pressure. She developed anasarca edema soon after amlodipine treatment was initiated. Laboratory test results for possible etiologies were negative. Discontinuation of amlodipine resulted in dramatic improvement.


CONCLUSIONS
To our knowledge, as of February 3, 2005, there have been no other reports of amlodipine-related anasarca edema in the English literature, and only one case was described in the Japanese literature. Pretibial edema is the most common adverse effect of amlodipine. Periocular and perioral edema have occurred less frequently, but anasarca edema has not emerged as a problem. An objective causality assessment revealed amlodipine to be a probable cause of anasarca edema.


CONCLUSIONS
In rare instances, amlodipine may cause generalized edema, which will resolve upon discontinuation of the drug.
Sener
Didem
D
Medical Faculty, Department of Internal Medicine, Hacettepe University, Ankara, Turkey.
Halil
M
M
Yavuz
Burcu Balam
BB
Cankurtaran
Mustafa
M
Arioğul
Servet
S
D000368:Aged; D017311:Amlodipine / Q000009:adverse effects*; D004487:Edema / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy
D017311:Amlodipine