title: Evaluation of a physiologically-based pharmacokinetic approach for simulating the first-time-in-animal study.
authors.affiliation: Pharmacokinetics, Dynamics and Metabolism, Nerviano Medical Sciences S.r.l., Via Pasteur 5, 20014 Nerviano, Milan, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Germani
authors.forename: Patrizia
authors.initials: P
authors.lastname: Crivori
authors.forename: Maurizio
authors.initials: M
authors.lastname: Rocchetti
authors.forename: Philip S
authors.initials: PS
authors.lastname: Burton
authors.forename: Alan G E
authors.initials: AG
authors.lastname: Wilson
authors.forename: Mark E
authors.initials: ME
authors.lastname: Smith
authors.forename: Italo
authors.initials: I
authors.lastname: Poggesi
mesh_terms: D000818:Animals; D001549:Benzamides / Q000493:pharmacokinetics; D003975:Diazepam / Q000493:pharmacokinetics; D008954:Models, Biological; D010599:Pharmacokinetics; D011433:Propranolol / Q000493:pharmacokinetics; D051381:Rats
chemical_list: D001549:Benzamides; D011433:Propranolol; D003975:Diazepam