Cisplatin nanocapsules.
Cisplatin nanocapsules represent a novel lipid formulation of the anticancer drug cis-diamminedichloroplatinum(II), in which nanoprecipitates of cisplatin are covered by a phospholipid bilayer coat consisting of an equimolar mixture of phosphatidylcholine and phosphatidylserine. Cisplatin nanocapsules are characterized by an unprecedented cisplatin-to-lipid molar ratio and exhibit strongly improved cytotoxicity against tumor cells in vitro compared with the free drug. Here, methods for preparing and characterizing cisplatin nanocapsules are reported.
de Kroon
Anton I P M
AI
Department of Biochemistry and Membranes, Utrecht University, Utrecht, The Netherlands.
Staffhorst
Rutger W H M
RW
Kruijff
Ben de
Bd
Burger
Koert N J
KN
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D002945:Cisplatin / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D006801:Humans; D015394:Molecular Structure; D049329:Nanostructures; D010743:Phospholipids / Q000737:chemistry
D000970:Antineoplastic Agents; D004337:Drug Carriers; D010743:Phospholipids; D002945:Cisplatin