title: The normalization of total clearances for intravenous injection drugs.
abstract: There have been reports wherein the total clearance of certain drugs exceeded the blood flow rate when blood concentration data following an intravenous injection was used. It is theoretically unusual that for drugs carried to the tissue by blood, the quantity eliminated is larger than the quantity carried. Nevertheless, the problem about total clearance still needs to be solved. The present paper proposes an equation to ensure that such unusual values do not arise.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Nishi-ku, Kobe, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Nishiyama
authors.forename: Shin
authors.initials: S
authors.lastname: Iguch
mesh_terms: D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*; D012016:Reference Values
chemical_list: D004364:Pharmaceutical Preparations
references.citation: Xenobiotica. 2001 Aug-Sep;31(8-9):591-8
references.pmid: 11569527
references.citation: J Pharmacobiodyn. 1989 Oct;12(10):608-15
references.pmid: 2630631