[Experimental studies of lumbar spinal stenosis].
Neurophysiologic function and ischemia causes neurogenic symptoms in lumbar spinal stenosis. Neurophysiologic function and potential therapeutic agents were investigated using a chronic cauda equina compression model that was developed according to a clinical pathogenesis. In the chronic cauda equina compression model, nerve conduction velocity and blood flow in spinal nerves decreased but mechanical allodynia was not induced. Prostaglandins and 5-HT receptor antagonist effected to improve blood flow in nerve roots after cauda equina compression;therefore, they might be potential agents for lumbar spinal stenosis.
Sekiguchi
Miho
M
Fukushima Medical University School of Medicine, Department of Orthopaedic Surgery.
Kikuchi
Shin-ichi
S
D000818:Animals; D002420:Cauda Equina / Q000503:physiopathology; D004285:Dogs; D011464:Epoprostenol / Q000627:therapeutic use; D008159:Lumbar Vertebrae; D051381:Rats; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists / Q000627:therapeutic use; D013130:Spinal Stenosis / Q000188:drug therapy / Q000209:etiology*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D011464:Epoprostenol