Carotid distensibility, baroreflex sensitivity, and orthostatic stress.
In this study, we tested the hypothesis that carotid arteries undergo rapid changes in distensibility on moving from the supine to head-up tilt (HUT) postures and, subsequently, that this change in carotid distensibility (cDa) might be associated with concurrent reductions in cardiovagal baroreflex sensitivity (BRS). Thus the effect of posture on carotid vascular mechanics and cardiovagal BRS with consideration for altered central hemodynamics (i.e., stroke volume; Doppler ultrasound) was examined. Carotid pulse pressure (cPP; Millar transducer) and contralateral B-mode ultrasound images were assessed at the carotid artery during supine and 60 degrees HUT postures. From these measures, cDa was calculated at 5-mmHg pressure increments experienced during the cardiac cycle (n = 6). cPP (n = 9) was not different in the two postures. A smaller stroke volume being ejected into a smaller carotid artery in HUT explained the maintenance of cPP in HUT. Also, compared with supine, cDa was reset to a lower level in HUT (main effect of posture; P < 0.05). Cardiovagal BRS (sequence method) was diminished in HUT vs. supine (P < 0.05). A positive correlation was observed between the tilt-induced changes in maximal cDa (in early systole) and cardiovagal BRS (r2 = 0.75; P < 0.05), but there was little predictive relationship between changes in cPP, systolic vessel dimensions, or average cDa and the corresponding change in BRS. The present results indicate that HUT elicits rapid changes in carotid artery mechanics and further suggest that reductions in the maximal cDa measured in early systole contribute to reduced cardiovagal BRS with HUT.
Steinback
Craig D
CD
Neurovascular Research Laboratory, School of Kinesiology, Rm. 3110 Thames Hall, The Univ. of Western Ontario, London, Ontario, Canada N6A 3K7.
O'Leary
Deborah D
DD
Bakker
Jason
J
Cechetto
Angela D
AD
Ladak
Hanif M
HM
Shoemaker
J Kevin
JK
D000328:Adult; D017704:Baroreflex / Q000502:physiology*; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology; D002339:Carotid Arteries / Q000502:physiology*; D004244:Dizziness / Q000503:physiopathology; D005260:Female; D006257:Head / Q000503:physiopathology*; D006321:Heart / Q000294:innervation* / Q000502:physiology*; D006801:Humans; D008297:Male; D016683:Supine Position / Q000502:physiology*; D018667:Tilt-Table Test / Q000379:methods; D014655:Vascular Resistance / Q000502:physiology