title: Hürthle (oncocytic) cell tumors of thyroid: etiopathogenesis, diagnosis and clinical significance.
abstract: The etiopathogenesis and the classification of oncocytic (Hürthle cell) tumors of the thyroid is reviewed with an emphasis on the role played by mitochondrial and nuclear genetic abnormalities that interfere with mitochondrial function. Oxyphilia is classified into primary or secondary and the so-called Hürthle cell carcinoma is divided into oncocytic (Hürthle cell) variants of papillary and follicular carcinoma.
authors.affiliation: Department of Pathology, Medical Faculty of the University of Porto, Portugal.
authors.forename: Manuel
authors.initials: M
authors.lastname: Sobrinho-Simões
authors.forename: Valdemar
authors.initials: V
authors.lastname: Máximo
authors.forename: Inês Vieira de
authors.initials: IV
authors.lastname: Castro
authors.forename: Elsa
authors.initials: E
authors.lastname: Fonseca
authors.forename: Paula
authors.initials: P
authors.lastname: Soares
authors.forename: Ginesa
authors.initials: G
authors.lastname: Garcia-Rostan
authors.forename: Manuel Cardoso de
authors.initials: MC
authors.lastname: Oliveira
mesh_terms: D018249:Adenoma, Oxyphilic / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D002467:Cell Nucleus / Q000235:genetics / Q000473:pathology; D004272:DNA, Mitochondrial; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000473:pathology; D013964:Thyroid Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology*
chemical_list: D004272:DNA, Mitochondrial