Radiation-induced cell death and dendritic cells: potential for cancer immunotherapy?
Dendritic cells are key orchestrators of the immune system. There is considerable interest in their use for treating cancer. Whether they initiate an effective cytotoxic response against antigen-bearing cells, or produce tolerance, depends on the context in which those antigens are presented. Ionising radiation, and the cell death it causes, has several properties that may facilitate such an effective response. A range of in-vitro and in-vivo data supports this, although potential problems exist that may require concurrent strategies.
Hatfield
P
P
Cancer Research UK Clinical Centre, St James's University Hospital, Leeds, UK. p.hatfield@cancermed.leeds.ac.uk
Merrick
A
A
Harrington
K
K
Vile
R
R
Bateman
A
A
Selby
P
P
Melcher
A
A
D000951:Antigens, Neoplasm; D017209:Apoptosis / Q000528:radiation effects*; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000502:physiology; D007167:Immunotherapy / Q000379:methods*; D009336:Necrosis; D009369:Neoplasms / Q000276:immunology / Q000532:radiotherapy; D011878:Radiotherapy
D000951:Antigens, Neoplasm