title: Optimal mitral annular and subvalvular shape change created by the Coapsys device to treat functional mitral regurgitation.
abstract: We have reported that the Myocor Coapsys (Myocor, Inc, Maple Grove, MN) device treated functional mitral regurgitation (MR) by reducing mitral annular dimension and repositioning papillary muscles. This study was conducted to evaluate the optimal Coapsys device sizing level. The Coapsys device was implanted in seven dogs after induction of MR by rapid ventricular pacing. The device consists of anterior and posterior pads connected by a subvalvular cord. The device was tightened in 5% increments of the left ventricular epicardial to epicardial dimension up to 40%. Hemodynamic and echocardiographic measurements were repeated at each tightening level. The Coapsys significantly reduced or eliminated functional MR, and the reduction was maximized at the 30% tightening level or lower in all cases. Although the left ventricular end diastolic volume decreased significantly, forward stroke volume was maintained until the 35% tightening level. The forward ejection fraction significantly increased from 33 +/- 24% at baseline to 62 +/- 42% at 40% tightening level. Mean aortic pressure decreased slightly but significantly. The Coapsys device can be applied over a broad range of tightening levels with significant reduction in MR without negative physiologic impact. This feature makes the device usable [corrected] in a variety of clinical settings.
authors.affiliation: Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Inoue
authors.forename: Zoran
authors.initials: Z
authors.lastname: Popović
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ootaki
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kopcak
authors.forename: Raymond
authors.initials: R
authors.lastname: Dessoffy
authors.forename: James D
authors.initials: JD
authors.lastname: Thomas
authors.forename: Patrick M
authors.initials: PM
authors.lastname: McCarthy
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002304:Cardiac Pacing, Artificial; D003971:Diastole; D004195:Disease Models, Animal; D004285:Dogs; D018618:Echocardiography, Doppler, Color; D005069:Evaluation Studies as Topic; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006439:Hemodynamics; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D020257:Ventricular Remodeling