title: Splenic infarction due to transient antiphospholipid antibodies induced by acute Epstein-Barr virus infection.
abstract: Splenic infarction is a rare feature of infectious mononucleosis (IM) due to Epstein-Barr virus (EBV), limited to three case reports. We report the first case of splenic infarction during acute EBV infection associated with the transient induction of antiphospholipid antibodies. We discuss the role of antiphospholipid antibodies in thrombosis in acute viral infections and postulate other mechanisms of thrombosis. Once other more common causes of splenic infarction, such as endocarditis and lymphoma, have been excluded, the possibility of viral-induced antiphospholipid antibodies should be considered.
authors.affiliation: Department of Infectious Diseases, Level 4, The Dickinson Building, The Prince of Wales Hospital, Randwick, NSW 2031, Australia. vanhal@iprimus.com.au
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: van Hal
authors.forename: Sanjaya
authors.initials: S
authors.lastname: Senanayake
authors.forename: Robyn
authors.initials: R
authors.lastname: Hardiman
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D004696:Endocarditis / Q000150:complications; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000276:immunology; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D008223:Lymphoma / Q000150:complications; D013159:Splenic Infarction / Q000000981:diagnostic imaging / Q000276:immunology* / Q000821:virology*; D014057:Tomography, X-Ray Computed
chemical_list: D017152:Antibodies, Antiphospholipid