title: Monofocal acute large demyelinating lesion mimicking brain glioma.
abstract: We report the case of a 34-year-old woman with clinical, neuroradiological and intraoperative histological findings, suggesting a low-grade astrocytic tumour. The demyelinating nature of the lesion was established through biopsy only after neurosurgery. The lesion size, in fact, greatly exceeded that of the perivenous demyelination seen in typical multiple sclerosis (MS) and tended to present as a space-occupying mass. This case underlines the importance of considering demyelinating isolated lesions in the differential diagnosis of a brain mass. Since misdiagnosis can result in unwarranted and aggressive therapy, it is critical for the neurologist to be aware of this serious diagnostic pitfall.
authors.affiliation: Department of Neuroscience, Neurological Clinic, University of Modena and Reggio Emilia, Via Del Pozzo 71, I-41100 Modena, Italy.
authors.forename: J
authors.initials: J
authors.lastname: Mandrioli
authors.forename: G
authors.initials: G
authors.lastname: Ficarra
authors.forename: G
authors.initials: G
authors.lastname: Callari
authors.forename: P
authors.initials: P
authors.lastname: Sola
authors.forename: E
authors.initials: E
authors.lastname: Merelli
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001254:Astrocytoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D001706:Biopsy / Q000379:methods; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003711:Demyelinating Diseases / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008264:Macrophages / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D009103:Multiple Sclerosis / Q000175:diagnosis; D009493:Neurosurgery / Q000379:methods; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule