title: The resistance to major antituberculous drugs of Mycobacterium tuberculosis strains isolated from the respiratory system specimens of tuberculosis patients in Duzce, Turkey.
abstract: Through generally curable, tuberculosis (TB) is becoming increasingly resistant to commonly used antibiotics. Drug-resistant and multidrug-resistant (MDR)-TB is a consequence of monotherapy, insufficient drug therapy and national TB control programs. The present study was designed to reveal the resistance to major antimicrobial drugs (isoniazid [INH], streptomycin [SM], ethambutol [EMB], and rifampicin [RIF]) of Mycobacterium tuberculosis isolated from the respiratory specimens of TB patients in Duzce, Turkey. A total of 62 TB patients (46 male, 16 female; age: 17 - 75 mean: 42 +/- 15.9) were included in the study; 52 (83.8%) were new cases and susceptible to all anti-TB drugs, while 10 (16.2%) were previously treated cases. Antimicrobial susceptibility tests were performed by the proportion method in Löwenstein-Jensen medium. Fifty-two of the 62 (83.8%) isolated M. tuberculosis strains were found to be susceptible to all drugs, and 7 (11.3%), 5 (8%), and 3 (4.8%) were resistant to SM, INH, and RIF, respectively; 3 (4.8%) were MDR. There were no EMB-resistant strains. The results of this study show the presence of drug-resistant and MDR strains of TB at Duzce in the northwest part of Turkey.
authors.affiliation: Department of Microbiology, Abant Izzet Baysal University, Düzce School of Medicine, Duzce 81620, Turkey. eflifozturk1968@yahoo.com
authors.forename: C Elif
authors.initials: CE
authors.lastname: Ozturk
authors.forename: Oner A
authors.initials: OA
authors.lastname: Balbay
authors.forename: Demet
authors.initials: D
authors.lastname: Kaya
authors.forename: Ismail
authors.initials: I
authors.lastname: Ceyhan
authors.forename: Ismet
authors.initials: I
authors.lastname: Bulut
authors.forename: Idris
authors.initials: I
authors.lastname: Sahin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000382:microbiology*; D014421:Turkey / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents