Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs).
A series of [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines were designed and synthesized as CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBA's).
Mulvihill
Mark J
MJ
OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. mark.mulvihill@osip.com
Kan
Julie L C
JL
Beck
Patricia
P
Bittner
Mark
M
Cesario
Cara
C
Cooke
Andrew
A
Keane
David M
DM
Nigro
Anthony I
AI
Nillson
Christy
C
Smith
Vanessa
V
Srebernak
Mary
M
Sun
Feng-Lei
FL
Vrkljan
Michael
M
Winski
Shannon L
SL
Castelhano
Arlindo L
AL
Emerson
David
D
Gibson
Neil
N
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System; D004123:Dimethylamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D008861:Microsomes / Q000201:enzymology; D051381:Rats; D000072516:Retinoic Acid 4-Hydroxylase
D000970:Antineoplastic Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D004123:Dimethylamines; D007093:Imidazoles; D003577:Cytochrome P-450 Enzyme System; D000072516:Retinoic Acid 4-Hydroxylase