Immunobiological [correction of Immunobioloical] activity of a new benzyl benzoate from the aerial parts of Solidago virga-aurea var. gigantea.
The chromatographic separation of the hexane soluble fraction of the methanol extract of the aerial parts of Solidago virga-aurea var. gigantea M(IQ*) (Compositae) led to the isolation of a new benzylbenzoate (1) together with four known benzylbenzoates (2-5). Their structures were determined as 2-methoxybenzyl-2-hydroxybenzoate (1), benzyl-2-hydroxy-6-methoxybenzoate (2), 2-methoxybenzyl-2,6-dimethoxybenzoate (3), 2-methoxybenzyl-2-methoxy-6-hydroxybenzoate (4), and benzyl-2,6-dimethoxybenzoate (5). Their structures were established by spectroscopic methods. Biological effects of compounds, 1 and 2, were investigated in vitro using mouse peritoneal macrophages. The benzylbenzoates (1 and 2) could serve as immunotherapeutic agents by stimulating macrophage functions, with potential use in the treatment of infectious diseases.
Choi
Sang Zin
SZ
Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon, Kyunggi-Do 440-746, Korea.
Choi
Sang Un
SU
Bae
Seong Yun
SY
Pyo
Suhk neung
Sn
Lee
Kang Ro
KR
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001565:Benzoates / Q000276:immunology* / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D035261:Plant Components, Aerial / Q000276:immunology*; D010936:Plant Extracts / Q000276:immunology / Q000302:isolation & purification / Q000494:pharmacology; D036624:Solidago
D000276:Adjuvants, Immunologic; D001565:Benzoates; D010936:Plant Extracts; C006723:benzyl benzoate