title: Antioxidant vitamin levels do not exhibit negative correlation with the extent of acute myocardial infarction.
abstract: Serum levels of vitamin E (VE), beta-carotene (BC) and vitamin C (VC) were determined in 50 patients with the first acute myocardial infarction (AMI) before starting thrombolytical treatment. VE and BC were determined by HPLC, VC spectrophotometrically. The reperfused patients were divided according to vitamin concentrations into four groups. The lowest quartile was compared with the rest of the studied population (VE: group with high (H)>15.6 microM>group with low (L), BC: H>0.07 microM>L, VC: H>25 microM>L) in the following parameters: extent of myocardial damage (area under the curves of troponin I, CK-MB during 48 h), arrhythmia and congestive heart failure occurrence, size of ejection fraction, positivity of ventricular late potentials. No significant differences between groups H and L for either VE, BC or VC were found (P 0.05). As no correlation between serum concentrations of vitamins E, C and beta-carotene and the extent and clinical course of AMI was found, the actual vitamin concentrations may be important for prevention of ischemic heart a disease, but they do not play a decisive role in the acute phase of myocardial infarction in humans.
authors.affiliation: Faculty of Chemical Technology, University of Pardubice, Strossova 239, 530 03 Pardubice, Czech Republic. vladimira.muzakova@upce.cz
authors.forename: V
authors.initials: V
authors.lastname: Muzáková
authors.forename: P
authors.initials: P
authors.lastname: Vojtísek
authors.forename: M
authors.initials: M
authors.lastname: Meloun
authors.forename: R
authors.initials: R
authors.lastname: Vanková
authors.forename: T
authors.initials: T
authors.lastname: Rousar
authors.forename: Z
authors.initials: Z
authors.lastname: Cervinková
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D014810:Vitamin E / Q000097:blood; D014815:Vitamins / Q000097:blood*; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D014815:Vitamins; D019207:beta Carotene; D014810:Vitamin E; D001205:Ascorbic Acid