title: Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells.
abstract: The molecular effects of Saussurea lappa extracts, a traditional medicine in Eastern Asia, on the fate of gastric carcinoma have not been understood. In this study, its cytostatic effects were examined using gastric AGS cancer cells. Its treatment resulted in apoptosis and G2-arrest in a dose- and time-dependent manner. The effects were attributed to the regulation of cyclins and pro-apoptotic molecules and suppression of anti-apoptotic molecules. Therefore, these results suggest that extracts of S. lappa root may be a candidate to deal with gastric cancers either by traditional herbal therapy or by combinational therapy with conventional chemotherapy.
authors.affiliation: Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea.
authors.forename: Seong Gyu
authors.initials: SG
authors.lastname: Ko
authors.forename: Hwang-Phill
authors.initials: HP
authors.lastname: Kim
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Jin
authors.forename: Hyun-Su
authors.initials: HS
authors.lastname: Bae
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Chong-Hyeong
authors.initials: CH
authors.lastname: Park
authors.forename: Jung Weon
authors.initials: JW
authors.lastname: Lee
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D030441:Saussurea / Q000737:chemistry*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects
chemical_list: D010936:Plant Extracts; D016159:Tumor Suppressor Protein p53