title: A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-gamma.
abstract: BACKGROUND
  Chronic granulomatous disease (CGD) is a rare disorder of phagocytes in which absence of superoxide and hydrogen peroxide production in phagocytes predisposes patients to bacterial and fungal infections. The most common fungal infections in these patients are caused by Aspergillus species.
  
  
  METHODS
  Here, we describe Aspergillus osteomyelitis of the ribs and hepatic abscess in a 5-year-old boy. The patient was successfully treated with Amphotericin B and INF-gamma.
  
  
  CONCLUSIONS
  With respect to the high frequency of aspergillosis in the CGD patient, immune deficiency should be investigated in patients with invasive aspergillosis. Moreover, using antifungal drugs as prophylaxis can improve the quality of life in these patients.
authors.affiliation: Department of Infectious Diseases, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran. smamishi@sina.tums.ac.ir <smamishi@sina.tums.ac.ir>
authors.forename: Setareh
authors.initials: S
authors.lastname: Mamishi
authors.forename: Kamiar
authors.initials: K
authors.lastname: Zomorodian
authors.forename: Farshid
authors.initials: F
authors.lastname: Saadat
authors.forename: Mohsen
authors.initials: M
authors.lastname: Gerami-Shoar
authors.forename: Bita
authors.initials: B
authors.lastname: Tarazooie
authors.forename: Seyad Ahmad
authors.initials: SA
authors.lastname: Siadati
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy*; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage*; D008297:Male
chemical_list: D000666:Amphotericin B; D007371:Interferon-gamma
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