title: Y-chromosome STR haplotype diversity in Brazilian populations.
abstract: A sample of 198 unrelated males distributed among the five geopolitical regions in Brazil were typed for the minimal Y-STR haplotype composed of microsatellite loci DYS19, DYS385I/II, DYS389I, DYS389II, DYS390, DYS391, DYS392 and DYS393. Gene frequency data, gene diversity, haplotype diversity and power of discrimination were estimated. An AMOVA indicated that 99.97% of the haplotypic variation is found within regions and only a small 0.03% and non significant variation is found among the five regions (Fst=0.00031, P-value=0.43). This result suggests that a single national database of Y-STR haplotypes can be used in the quantitative assessment of matches in forensic casework in the Brazilian population. A significant haplotype diversity of 99.8% was found and 172 different haplotypes were observed in 198 chromosomes. Haplotype (14-11, 14-13-29-24-11-13-13) with five occurrences in 198 chromosomes was the most frequent in Brazil.
authors.affiliation: Heréditas Tecnologia em Análise de DNA Ltda., SHIN CA 02, Lote 19, Brasilia, DF 71505-000, Brazil.
authors.forename: Dario
authors.initials: D
authors.lastname: Grattapaglia
authors.forename: Sergei
authors.initials: S
authors.lastname: Kalupniek
authors.forename: Claudia S
authors.initials: CS
authors.lastname: Guimarães
authors.forename: Mônica A
authors.initials: MA
authors.lastname: Ribeiro
authors.forename: Polyanna S
authors.initials: PS
authors.lastname: Diener
authors.forename: Camila N
authors.initials: CN
authors.lastname: Soares
mesh_terms: D001938:Brazil; D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting / Q000379:methods; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020080:Tandem Repeat Sequences