title: Biochemical serum profiles in dogs experimentally infected with Angiostrongylus vasorum (Baillet, 1866).
abstract: The biochemical profiles of crossbred dogs experimentally infected with the parasite Angiostrongylus vasorum were studied. Two groups of five dogs were experimentally inoculated with 50 and 100 third stage infective larvae (L3) of A. vasorum per kilogram of body weight. A third group of five uninfected animals were used as control. Serum from these animals were used for biochemical tests to measure total and fractioned proteins, urea, creatinine and to determine the activities of aspartate (AST), alanine (ALT) aminotransferase, gamma-glutamyl transferase (GGT), alkaline phosphatase (PAL) and creatine kinase isoenzyme MB (CK-MB). The alpha-1, alpha-2 and beta-globulins fractions showed alterations during acute phase of the infection. No modifications were observed in the biochemical profiles of ALT, AST, GGT, PAL, urea and creatinine. CK-MB was shown to be a good early indicator of cardiac injury in dogs experimentally infected with A. vasorum.
authors.affiliation: Av. Pará 1720, Bloco 4C, Laboratório de Parasitologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Bairro Umuarama, Uberlândia, Minas Gerais, Brazil. cury@umuarama.ufu.br
authors.forename: M C
authors.initials: MC
authors.lastname: Cury
authors.forename: M P
authors.initials: MP
authors.lastname: Guimarães
authors.forename: W S
authors.initials: WS
authors.lastname: Lima
authors.forename: M C M
authors.initials: MC
authors.lastname: Caldeira
authors.forename: T R
authors.initials: TR
authors.lastname: Couto
authors.forename: K
authors.initials: K
authors.lastname: Murta
authors.forename: M G
authors.initials: MG
authors.lastname: Carvalho
authors.forename: J M B
authors.initials: JM
authors.lastname: Baptista
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000801:Angiostrongylus / Q000254:growth & development*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000097:blood* / Q000201:enzymology / Q000469:parasitology*; D004285:Dogs; D005916:Globulins / Q000378:metabolism; D007527:Isoenzymes / Q000097:blood; D017206:Strongylida Infections / Q000097:blood* / Q000201:enzymology / Q000469:parasitology / Q000662:veterinary*; D014508:Urea / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D001798:Blood Proteins; D005916:Globulins; D007527:Isoenzymes; D014508:Urea; D003404:Creatinine; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; D000469:Alkaline Phosphatase
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