Supramolecular assemblies of DNA with neutral nucleoside amphiphiles.
A neutral uridine-based amphiphile is described which condenses plasmid DNA. AFM studies show that the three distinct structural components of the amphiphile (i.e, nucleobase, alkyl chains, and poly(ethylene glycol)) are required for the formation of DNA-amphiphile supramolecular assemblies on a mica surface.
Barthelemy
Philippe
P
Faculté des sciences d'Avignon, France.
Prata
Carla A H
CA
Filocamo
Shaun F
SF
Immoos
Chad E
CE
Maynor
Benjamin W
BW
Hashmi
S A Nadeem
SA
Lee
Stephen J
SJ
Grinstaff
Mark W
MW
D004247:DNA / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D018625:Microscopy, Atomic Force / Q000379:methods; D008968:Molecular Conformation; D011092:Polyethylene Glycols / Q000737:chemistry; D012680:Sensitivity and Specificity; D012995:Solubility; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*; D014529:Uridine / Q000737:chemistry*
D046911:Macromolecular Substances; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D004247:DNA; D014529:Uridine