title: Tuberculosis deaths in countries with high HIV prevalence: what is their use as an indicator in tuberculosis programme monitoring and epidemiological surveillance?
abstract: Although the reduction of tuberculosis deaths is one of the aims of tuberculosis control, it has not always been a priority for National Tuberculosis Programmes (NTPs). The usual explanation is that death as a treatment outcome not associated with ongoing tuberculosis transmission is not relevant to the public health objective of cutting the cycle of disease transmission. However, death as an adverse outcome for tuberculosis patients and their families is an important indicator in NTP monitoring. Global health targets agreed as part of the Millennium Development Goals include the reduction of tuberculosis deaths. Tuberculosis deaths as an indicator of the impact of tuberculosis control measures are therefore important in the epidemiological surveillance of progress towards these targets. These considerations are particularly important in countries with high human immunodeficiency virus (HIV) prevalence where HIV has exacerbated the tuberculosis epidemic and is now the single best predictor of tuberculosis incidence. Tuberculosis deaths are also closely linked to HIV prevalence. Routine NTP data on tuberculosis cohort deaths are important in programme monitoring, and improvements in recording and reporting of deaths would help to overcome limitations in their accuracy. As routine NTP data on tuberculosis cohort deaths are insufficient as an indicator in epidemiological surveillance regarding the impact of NTPs on tuberculosis mortality, measuring progress towards targets for reduced tuberculosis deaths depends on improved national vital registration systems for a more accurate determination of tuberculosis mortality.
authors.affiliation: Stop TB Department, World Health Organization, Geneva, Switzerland. maherd@who.ch
authors.forename: D
authors.initials: D
authors.lastname: Maher
authors.forename: C J
authors.initials: CJ
authors.lastname: Watt
authors.forename: B G
authors.initials: BG
authors.lastname: Williams
authors.forename: M
authors.initials: M
authors.lastname: Raviglione
authors.forename: C
authors.initials: C
authors.lastname: Dye
mesh_terms: D004784:Environmental Monitoring; D004812:Epidemiologic Methods; D062665:Epidemiological Monitoring; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D015995:Prevalence; D014376:Tuberculosis / Q000401:mortality*