New developments in magnetic resonance imaging of the brain.
Magnetic resonance imaging (MRI) continues to have a large impact on the diagnosis and management of a number of diseases, especially diseases associated with brain injury. The strengths of MRI are the unique contrast that can be obtained, and the fact that it is not harmful and that it can be readily applied to human and animal models. The past decade has seen development of functional MRI techniques that measure aspects of hemodynamics and water diffusion that are playing an important role. Indeed, these techniques are having a major impact on management of brain injury. The development of MRI continues at a rapid pace and a renewed push to increased spatial and temporal resolution will extend the applicability of anatomical and functional MRI. Increased interest in molecular imaging using MRI is increasing the number of processes that can be imaged in the brain. This work reviews some new developments that are being made in anatomical, functional, and molecular MRI of the brain, with comments about usefulness for work in the area of neuroprotection.
Koretsky
Alan P
AP
Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20812, USA. koretskya@ninds.nih.gov
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D001930:Brain Injuries / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D051379:Mice; D011859:Radiography
Invest Radiol. 1984 Nov-Dec;19(6):491-8
6511256
Biophys J. 1999 Jan;76(1 Pt 1):103-9
9876127
Proc Natl Acad Sci U S A. 1990 Apr;87(8):3112-6
2326269
Magn Reson Med. 1990 May;14(2):330-46
2345513
Magn Reson Q. 1989 Oct;5(4):263-81
2701285
Proc Natl Acad Sci U S A. 1990 Dec;87(24):9868-72
2124706
Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):212-6
1729691
Stroke. 1992 Nov;23(11):1602-12
1440708
Stroke. 1994 Jun;25(6):1252-61; discussion 1261-2
8202989
Magn Reson Med. 1995 Feb;33(2):200-8
7707910
Science. 1995 May 12;268(5212):889-93
7754376
J Neurotrauma. 1995 Dec;12(6):1015-25
8742130
Magn Reson Med. 1996 Nov;36(5):715-25
8916022
Ann Neurol. 1997 May;41(5):574-80
9153518
J Neurophysiol. 1997 May;77(5):2780-7
9163392
Magn Reson Med. 1997 Sep;38(3):378-88
9339438
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15256-61
10611372
Exp Neurol. 2000 Mar;162(1):61-72
10716889
Kidney Int. 2000 Sep;58(3):1300-10
10972694
Nat Genet. 2001 Feb;27(2):209-14
11175792
Stroke. 2001 Apr;32(4):933-42
11283394
J Comput Assist Tomogr. 2001 May-Jun;25(3):431-5
11351195
Nature. 2001 Jul 12;412(6843):150-7
11449264
Magn Reson Med. 2001 Sep;46(3):424-9
11550231
Magn Reson Med. 2001 Nov;46(5):884-90
11675639
Magn Reson Med. 2001 Nov;46(5):1018-22
11675656
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12766-71
11606760
Nat Med. 2001 Nov;7(11):1241-4
11689890
Annu Rev Biomed Eng. 1999;1:611-48
11701502
Stroke. 2002 Jan;33(1):87-94
11779894
Ann Neurol. 2002 Jan;51(1):11-3
11782978
J Magn Reson Imaging. 2002 Feb;15(2):130-6
11836767
Nat Rev Cancer. 2002 Jan;2(1):11-8
11902581
Magn Reson Med. 1998 Jul;40(1):1-13
9660547
Magn Reson Med. 1998 Nov;40(5):740-8
9797158
Neuroimage. 2002 Jun;16(2):441-8
12030829
Neuroscience. 2002;111(4):761-73
12031403
Neuroscience. 2002;112(2):467-74
12044464
Neuron. 2002 May 30;34(5):685-700
12062017
Magn Reson Med. 2002 Jun;47(6):1218-27
12111969
J Cereb Blood Flow Metab. 2002 Aug;22(8):899-907
12172375
Magn Reson Med. 2002 Oct;48(4):735-8
12353293
Cerebrovasc Dis. 2002;14(3-4):187-96
12403951
Magn Reson Med. 2002 Nov;48(5):852-9
12418000
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15182-7
12407177
Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16267-72
12444255
Neuroimage. 2002 Sep;17(1):272-86
12482083
J Neurotrauma. 2002 Sep;19(9):1029-37
12482116
Neuroreport. 2002 Dec 20;13(18):2487-92
12499854
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2981-6
12601170
Genes Dev. 2003 Mar 1;17(5):545-80
12629038
Brain Res. 2003 May 2;971(1):95-106
12691842
Neuroimage. 2003 May;19(1):190-9
12781738
Magn Reson Med. 2003 Jul;50(1):7-12
12815672
Magn Reson Med. 2003 Aug;50(2):293-302
12876705
Neurotoxicology. 1984 Spring;5(1):13-35
6538948
Sci Am. 1988 Sep;259(3):118-27
3064299