title: Evidence for a hydrogen abstraction mechanism in P450-catalyzed N-dealkylations.
abstract: The experimental evidence presented in this manuscript suggest against the widely accepted single electron/proton transfer mechanism for P450 catalyzed N-dealkylations and provides strong support for a hydrogen atom abstraction mechanism.
authors.affiliation: Department of Chemistry, Wichita State University, Wichita, Kansas 67260, USA.
authors.forename: Mehul
authors.initials: M
authors.lastname: Bhakta
authors.forename: Paul F
authors.initials: PF
authors.lastname: Hollenberg
authors.forename: Kandatege
authors.initials: K
authors.lastname: Wimalasena
mesh_terms: D000478:Alkylation; D000818:Animals; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000378:metabolism*; D004583:Electrons; D006859:Hydrogen / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D011522:Protons; D051381:Rats
chemical_list: D011522:Protons; D006859:Hydrogen; D003577:Cytochrome P-450 Enzyme System