title: (-)-Echinobetaine A: isolation, structure elucidation, synthesis, and SAR studies on a new nematocide from a southern Australian marine sponge, Echinodictyum sp.
abstract: A nematocidal agent present in a southern Australian marine sponge of the genus Echinodictyum has been isolated and identified by detailed spectroscopic analysis and total synthesis as the novel betaine (-)-echinobetaine A (6). Preliminary SAR investigations have been undertaken.
authors.affiliation: Centre for Molecular Biodiversity, Institute for Molecular Biosciences, University of Queensland, St. Lucia, Queensland 4072, Australia. r.capon@imb.uq.edu.au
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Capon
authors.forename: Dat
authors.initials: D
authors.lastname: Vuong
authors.forename: Ernest
authors.initials: E
authors.lastname: Lacey
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Gill
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D001622:Betaine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000969:Antinematodal Agents; C498483:echinobetaine A; D001622:Betaine