title: Current and lifetime psychiatric illness in women with Turner syndrome.
abstract: Abnormalities in quality of life and cognitive measures have been observed in women with Turner syndrome (TS), and a relationship between these phenomena and chromosomal constitution has been suggested. In contrast, few studies have systematically evaluated the presence of mood and behavioral syndromes in these women. In this study, 100 TS women were administered the Structured Clinical Interview for DSM IV after a two-week period during which their hormone replacement had been discontinued. The majority of women who met criteria for a psychiatric condition had a mood or anxiety disorder. Overall, 52 (52%) of the TS women met criteria for a current or a past depressive or anxiety disorder. Eighteen of the women with TS met criteria for a current Axis I psychiatric disorder [Depression--major (n = 5), minor (n = 5), dysthymia (n = 1); Anxiety (n = 9)]. Forty-six of the women with TS met criteria for a past Axis I psychiatric illness [Depression: unipolar (n = 41), bipolar (n = 3); Anxiety (n= 7); eating disorder (n =6); substance dependence (n = 3)]. Five women with TS met criteria for an Axis II personality disorder. Women with TS reported a higher rate of lifetime depression compared with rates observed in community-based studies but similar to those obtained from gynecologic clinic samples.
authors.affiliation: Behavioral Endocrinology Branch, National Institute of Mental Health, National Institutes of Health, Department of Health & Human Services, Bethesda, MD 20892-1276, USA.
authors.forename: Graca
authors.initials: G
authors.lastname: Cardoso
authors.forename: Robert
authors.initials: R
authors.lastname: Daly
authors.forename: Nazli A
authors.initials: NA
authors.lastname: Haq
authors.forename: Lori
authors.initials: L
authors.lastname: Hanton
authors.forename: David R
authors.initials: DR
authors.lastname: Rubinow
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Bondy
authors.forename: Peter
authors.initials: P
authors.lastname: Schmidt
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000453:epidemiology; D003863:Depression / Q000453:epidemiology; D015914:Estrogen Replacement Therapy; D001068:Feeding and Eating Disorders / Q000453:epidemiology; D005260:Female; D005838:Genotype; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000008:administration & dosage; D006801:Humans; D001523:Mental Disorders / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D019964:Mood Disorders / Q000453:epidemiology; D013963:Thyroid Hormones / Q000008:administration & dosage; D014424:Turner Syndrome / Q000235:genetics / Q000523:psychology*
chemical_list: D013963:Thyroid Hormones; D019382:Human Growth Hormone