Glaucoma medication and aqueous humor dynamics.
OBJECTIVE
This review evaluates current concepts regarding the effects of glaucoma medication on aqueous humor dynamics and the impact of this on intraocular pressure control and drug selection in clinical practice.


RESULTS
Calculations based on the Friedenwald and Goldmann equations have predicted that glaucoma medications that increase pressure-sensitive aqueous outflow will dampen intraocular pressure spikes and therefore may be advantageous over drugs that do not increase outflow facility.


CONCLUSIONS
Further experimental research is required to verify the influence of increased outflow facility on intraocular pressure fluctuation and the effect of this on glaucoma progression.
Crowston
Jonathan G
JG
Hamilton Glaucoma Center, University of California San Diego, La Jolla, California 92093-0946, USA. jcrowston@eyecenter.ucsd.edu
Weinreb
Robert N
RN
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000378:metabolism*; D005901:Glaucoma / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans
D000959:Antihypertensive Agents