title: Correlation of periacinar retraction clefting in needle core biopsies and corresponding prostatectomy specimens of patients with prostatic adenocarcinoma.
abstract: One of the underemphasized supportive criteria for the diagnosis of prostatic cancer is the presence of retraction clefting around neoplastic glands. We analyzed a series of 152 prostatic cancer cases to determine the frequency, extent, and correlation of periacinar retraction clefting between needle core biopsies (NCB) and corresponding matched radical prostatectomy (RP) specimens. Clefting was significantly more frequent in neoplastic compared to nonneoplastic acini in NBC and RP (p<0.05). There was no significant difference in the frequency of retraction clefting in neoplastic acini between NCB and corresponding RP (p>0.05). We have also found a concordance in matched RP and NCB (Kappa=0.582). We conclude that periacinar retraction clefting appears more frequently in neoplastic acini and could serve as a reliable criterion in the diagnosis of prostatic adenocarcinoma.
authors.affiliation: Ljudevit Jurak University Department of Pathology, Sestre milosrdnice University Hospital, Zagreb, Croatia.
authors.forename: Bozo
authors.initials: B
authors.lastname: Kruslin
authors.forename: Davor
authors.initials: D
authors.lastname: Tomas
authors.forename: Hermann
authors.initials: H
authors.lastname: Rogatsch
authors.forename: Ante
authors.initials: A
authors.lastname: Reljić
authors.forename: Majda
authors.initials: M
authors.lastname: Vucić
authors.forename: Drinko
authors.initials: D
authors.lastname: Balicević
authors.forename: Mladen
authors.initials: M
authors.lastname: Belicza
authors.forename: Gregor
authors.initials: G
authors.lastname: Mikuz
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D001707:Biopsy, Needle; D006801:Humans; D008297:Male; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery