title: From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors.
authors.affiliation: Medicinal Chemistry, Research Center Europe, Schering AG, 13342 Berlin, Germany. rolf.jautelat@schering.de
authors.forename: Rolf
authors.initials: R
authors.lastname: Jautelat
authors.forename: Thomas
authors.initials: T
authors.lastname: Brumby
authors.forename: Martina
authors.initials: M
authors.lastname: Schäfer
authors.forename: Hans
authors.initials: H
authors.lastname: Briem
authors.forename: Gerhard
authors.initials: G
authors.lastname: Eisenbrand
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwahn
authors.forename: Martin
authors.initials: M
authors.lastname: Krüger
authors.forename: Ulrich
authors.initials: U
authors.lastname: Lücking
authors.forename: Olaf
authors.initials: O
authors.lastname: Prien
authors.forename: Gerhard
authors.initials: G
authors.lastname: Siemeister
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D001665:Binding Sites; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D004396:Coloring Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D050759:Cyclin-Dependent Kinase Inhibitor p21; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017434:Protein Structure, Tertiary; D012995:Solubility; D013449:Sulfonamides / Q000737:chemistry
chemical_list: D018797:Cell Cycle Proteins; D004396:Coloring Agents; D050759:Cyclin-Dependent Kinase Inhibitor p21; D007211:Indoles; D047428:Protein Kinase Inhibitors; D013449:Sulfonamides; D000255:Adenosine Triphosphate; C027185:indirubin