title: Efficacy of mirazid in comparison with praziquantel in Egyptian Schistosoma mansoni-infected school children and households.
abstract: This trial investigated the anti-schistosomal activity of mirazid in comparison with that of praziquantel in Schistosoma mansoni-infected Egyptian patients. The sample population was composed of 1,131 individuals (459 school children and 672 household members). Screening for S. mansoni was conducted using the standard Kato Katz technique. Four slides from a single stool sample were examined before treatment, and four slides per sample from stool samples obtained on three consecutive days were examined post-treatment. All positive eligible subjects were randomly assigned into two groups, the first received mirazid at a dose of 300 mg/day for three consecutive days, and the second received praziquantel at a single dose of 40 mg/kg. All treated subjects were examined 4-6 weeks post-treatment. Mirazid showed low cure rates of 9.1% and 8.9% in S. mansoni-infected school children and household members, respectively, compared with cure rates of 62.5% and 79.7%, respectively, in those treated with praziquantel. Therefore, we do not recommend mirazid as an agent to control schistosomiasis.
authors.affiliation: Theodor Bilharz Research Institute, Warrak El-Hadar, Giza, Egypt. sanaabotros@link.net <sanaabotros@link.net>
authors.forename: Sanaa
authors.initials: S
authors.lastname: Botros
authors.forename: Hanan
authors.initials: H
authors.lastname: Sayed
authors.forename: Howaida
authors.initials: H
authors.lastname: El-Dusoki
authors.forename: Hoda
authors.initials: H
authors.lastname: Sabry
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Rabie
authors.forename: Maged
authors.initials: M
authors.lastname: El-Ghannam
authors.forename: Moataz
authors.initials: M
authors.lastname: Hassanein
authors.forename: Yehia Abd
authors.initials: YA
authors.lastname: El-Wahab
authors.forename: Dirk
authors.initials: D
authors.lastname: Engels
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D004534:Egypt / Q000453:epidemiology; D005191:Family Characteristics; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000302:isolation & purification; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D012556:Schistosomicides / Q000008:administration & dosage / Q000627:therapeutic use*; D013729:Terpenes / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D012556:Schistosomicides; D013729:Terpenes; D011223:Praziquantel; C014119:myrrh oil