Tissue engineering for meniscus repair.
Meniscus injury is common in today's active society. Despite the frequent presentation of meniscus injury, the decision to repair or resect a torn meniscus is not always straightforward. Current repair techniques are effective in the peripheral vascularized meniscus, but their success is not dependable in the avascularized zone. Tissue engineering, a discipline that combines the technologies of cell culture and biodegradable scaffolds to deliver a cellular repair, may be one future answer to this problem. The concept of using cell-based repair for torn menisci could improve healing of lesions in the avascular zone and broadly expand the indication for repair rather than removal, obviating the need for meniscectomy. This article reviews current advances in the relatively new field of tissue engineering toward the development of a tissue-engineered meniscal repair technique.
Adams
Samuel B
SB
Division of Orthopedic Surgery, Duke University Medical Center, Durham, NC, USA.
Randolph
Mark A
MA
Gill
Thomas J
TJ
D019902:Chondrocytes / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology; D015316:Genetic Therapy; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D007718:Knee Injuries / Q000628:therapy*; D000070600:Tibial Meniscus Injuries; D023822:Tissue Engineering / Q000379:methods*
D006133:Growth Substances