title: Effect of radiofrequency catheter ablation on plasma B-type natriuretic peptide.
abstract: The study was designed to investigate the impact of radiofrequency catheter ablation on the plasma level of B-type natriuretic peptide (BNP). In 36 patients who underwent catheter ablation of paroxysmal supraventricular tachycardia, the plasma level of BNP was analyzed before and after the ablation procedures. The plasma BNP at baseline, 30 minutes after the ablation, 3 and 24 hours after the ablation was 12.78 +/- 2.47, 18.45 +/- 4.02 (P = 0.446), 43.54 +/- 8.12 (P = 0.0001), and 17.88 +/- 4.71 (P = 0.493) pg/mL, respectively. Plasma troponin I was also increased 3 and 24 hours after the ablation (n = 10, P < 0.05). Multivariate regression analysis showed a significant correlation between the levels of BNP 3 hours after ablation and the preablation BNP and the total radiofrequency energy used for the ablation. We conclude that radiofrequency catheter ablation of supraventricular tachycardia increases the plasma level of BNP. The clinical significance of the ablation-induced increase in BNP needs to be further investigated.
authors.affiliation: Department of Cardiology, The Fifth Affiliated Hospital of Wenzhou Medical College, Lishui City, Zhejiang Province, the People's Republic of China.
authors.forename: Liping
authors.initials: L
authors.lastname: Chen
authors.forename: Tiemin
authors.initials: T
authors.lastname: Wei
authors.forename: Chunlai
authors.initials: C
authors.lastname: Zeng
authors.forename: Qunying
authors.initials: Q
authors.lastname: Chen
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Shi
authors.forename: Lexin
authors.initials: L
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D017115:Catheter Ablation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012044:Regression Analysis; D013614:Tachycardia, Paroxysmal / Q000097:blood* / Q000503:physiopathology / Q000601:surgery*; D013617:Tachycardia, Supraventricular / Q000097:blood* / Q000503:physiopathology / Q000601:surgery*
chemical_list: D020097:Natriuretic Peptide, Brain