[Experimental study on the antibacterial effects of zirconium phosphate gauze loaded with silver on the common bacteria on rat burn wound].
OBJECTIVE
To investigate the antibacterial effects of zirconium phosphate gauze loaded with silver on rat burn wounds seeded with commonly seen bacteria.


METHODS
Wistar rats were employed in the study and were scalded and infected. The minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) of zirconium phosphate loaded with silver were determined by double dilution in tubes. The effect on wound healing and the subeschar bacterial count of the rat burn wounds were observed after the wounds had been covered by gauze loaded with zirconium phosphate and silver, and also with the gauze which has been rinsed for 20 times.


RESULTS
The MIC of silver loaded zirconium phosphate on Staphylococcus aureus, Pseudomonas aeruginosa and E. coli were 8, 8 and 16 mg/L, respectively, while the MBC were 16, 8 and 32 mg/L, respectively. The subeschar bacterial count in the burn wounds with the gauze with silver loaded zirconium phosphate was ten times lower than that in those which were treated with gauze with SD-Ag and 100 times lower than that with ordinary gauze. But there was no difference in the bacterial count between the wounds which were treated with fresh gauze with silver loaded zirconium phosphate and that with the gauze which has been rinsed for 20 times (P > 0.05). Furthermore, wound healing seemed to be better with the gauze with silver loaded zirconium phosphate when compared with those by the other two kinds of gauze.


CONCLUSIONS
The silver loaded zirconium phosphate was found to be bacteriocidal against bacteria commonly seen in the burn wounds.
Tang
Jin
J
Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, The Third Military Medical University, Chongqing 400038, P.R. China.
Wu
Jun
J
Yi
Shao-xuan
SX
Wang
Ru-peng
RP
Wang
Xi-hua
XH
Ma
Bing
B
Yuan
Jun
J
Chen
Xi-wei
XW
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001458:Bandages; D002056:Burns / Q000382:microbiology / Q000628:therapy*; D015169:Colony Count, Microbial; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012834:Silver / Q000008:administration & dosage / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000382:microbiology / Q000628:therapy*; D015040:Zirconium / Q000008:administration & dosage / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; C027006:zirconium phosphate; D012834:Silver; D015040:Zirconium