title: Sevoflurane but not propofol preserves myocardial function during minimally invasive direct coronary artery bypass surgery.
abstract: Volatile anesthetics exert cardioprotective properties in experimental and clinical studies. We designed this study to investigate the effects of sevoflurane on left ventricular (LV) performance during minimally invasive direct coronary artery bypass grafting (MIDCAB) without cardiopulmonary bypass. Fifty-two patients scheduled for MIDCAB surgery were randomly assigned to a propofol or a sevoflurane group. Apart from the anesthetics used, there was no difference in surgical and anesthetic management. After determination of cardiac troponin T, creatine kinase, and creatine kinase MB, electrocardiographic (ECG) data and echocardiography variables (myocardial performance index and early to atrial filling velocity ratio) the left anterior descending coronary artery (LAD) was clamped until anastomosis with the left internal mammary artery was completed. During LAD occlusion and during reperfusion, echocardiography measurements were repeated. Blood samples were obtained repeatedly for up to 72 h. After LAD occlusion, myocardial performance index and early to atrial filling velocity ratio in the propofol group deteriorated significantly from 0.40 +/- 0.12 and 1.29 +/- 0.35 to 0.49 +/- 0.10 and 1.13 +/- 0.22, respectively, whereas there was no change in the sevoflurane group. In the propofol group myocardial performance index remained increased (0.47 +/- 0.11) compared with baseline during reperfusion. There were no significant differences in ECG and laboratory values between groups. In conclusion, during a brief period of ischemia in patients undergoing MIDCAB surgery, sevoflurane preserved myocardial function better than propofol.
authors.affiliation: Department of Anaesthesiology and Intensive Care Medicine and Department of Cardiothoracic and Vascular Surgery University Hospital Schleswig-Holstein, Campus Kiel, Germany.
authors.forename: Berthold
authors.initials: B
authors.lastname: Bein
authors.forename: Jochen
authors.initials: J
authors.lastname: Renner
authors.forename: Dorothee
authors.initials: D
authors.lastname: Caliebe
authors.forename: Jens
authors.initials: J
authors.lastname: Scholz
authors.forename: Andrea
authors.initials: A
authors.lastname: Paris
authors.forename: Sandra
authors.initials: S
authors.lastname: Fraund
authors.forename: Wiebke
authors.initials: W
authors.lastname: Zaehle
authors.forename: Peter H
authors.initials: PH
authors.lastname: Tonner
mesh_terms: D000328:Adult; D000368:Aged; D001026:Coronary Artery Bypass; D017548:Echocardiography, Transesophageal; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D015742:Propofol / Q000494:pharmacology*; D000077149:Sevoflurane
chemical_list: D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol
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