[Cell-cooperation integrated test for the detection of immune reactivity to Shiga-toxin in patients with acute intestine infection].
Described are the results of approbation of the cell-migration screening test reflecting the outcome of cooperation between T- and B-cells and macrophages. It was shown, in adults and children with intestine infection, to be a highly-effective tool for the detection of suppressed immune response during early disease stages at stimulation in vitro by Shiga toxin at nano- and picogram concentration; it can also be used for the evaluation of the shaping specific anti-Shiga-toxic immune response. The parameters of the migration activity of peripheral-blood leucocytes at exacerbation and convalescence were demonstrated to correlate with the age of sick children and with the severity of intestine infection as well as with the level of a Shiga-like toxin detected in coprofilters and circulating immune complexes.
Belaia
O F
OF
Pak
S G
SG
Suslov
A P
AP
Iudina
Iu V
IuV
D000328:Adult; D000367:Age Factors; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D006403:Hematologic Tests / Q000379:methods; D006801:Humans; D007410:Intestinal Diseases / Q000276:immunology* / Q000382:microbiology; D007962:Leukocytes / Q000276:immunology*; D011237:Predictive Value of Tests; D022621:Shiga Toxin / Q000276:immunology / Q000494:pharmacology*
D022621:Shiga Toxin