Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats.
The aim of this study was to examine whether bovine colostrum was able to prevent the NSAID induced small intestinal damage in animals. The animal model population of the study consisted of 4 groups: control group, diclofenac group, diclofenac with 10% low fat milk group and diclofenac with 5% colostrum group. The animals with milk or colostrum were fed with 10% low fat milk or 5% colostral solution for 5 days before the administration of diclofenac. Gut injuries were induced by administration of a single dose of diclofenac (100 mg/kg orally). Epithelial permeability values (24 hour urinary excretion of 51Cr-ethylenediaminetetraacetic acid [51Cr-EDTA]), enteric aerobic bacterial counts, serum biochemical profiles and pathologic findings of distal ileum were measured. Diclofenac caused a marked increase in the intestinal permeability, enteric bacterial numbers and intestinal villous damage, and enteric protein and albumin loss. Combined administration of bovine colostrum reduced the increase in intestinal permeability, enteric bacterial overgrowth, protein losing enteropathy and mucosal villous damage of the small intestine induced by diclofenac. Bovine colostrum may have a beneficial effect in prevention of NSAID induced small intestinal injuries.
Kim
Jeong Wook
JW
Departments of Internal Medicine, Kangbuk Samsung Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jeonwk@samsung.co.kr
Jeon
Woo Kyu
WK
Yun
Jung Won
JW
Park
Dong Il
DI
Cho
Yong Kyun
YK
Sung
In Kyung
IK
Sohn
Chung Il
CI
Kim
Byung Ik
BI
Yeom
Joon Sup
JS
Park
Hyo Soon
HS
Kim
Eun Jeong
EJ
Shin
Myong Suk
MS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002417:Cattle; D003126:Colostrum; D004008:Diclofenac / Q000009:adverse effects*; D005260:Female; D007082:Ileum / Q000187:drug effects / Q000382:microbiology / Q000502:physiology; D007410:Intestinal Diseases / Q000139:chemically induced / Q000382:microbiology / Q000517:prevention & control*; D008297:Male; D023421:Models, Animal; D010539:Permeability / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac