title: Microencapsulation peptide and protein drugs delivery system.
abstract: Many methods were used to devise peptide and protein drugs delivery system (DDS). Because of their relatively large size, they have low transdermal bioavailabilities. In systemic delivery of proteins, biodegradable material as parenteral depot formulation occupy an important place because of several aspects like protection of sensitive proteins from degradation, prolonged or modified release, pulsatile release patterns. The main objective in developing controlled release protein injectables is avoidance of regular invasive doses which in turn provide patient compliance, comfort as well as control over blood levels. This review article presents the outstanding contributions in field of microencapsulation as protein delivery systems and different approaches of protein delivery are described. Then discusses how these advances may be applied to resolve the challenges face the development of microcapsule for the controllable delivery of protein drugs.
authors.affiliation: Key Laboratory of Biomechanics & Tissue Engineering under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China.
authors.forename: Chuanyun
authors.initials: C
authors.lastname: Dai
authors.forename: Bochu
authors.initials: B
authors.lastname: Wang
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000464:Alginates; D002214:Capsules; D048271:Chitosan; D004337:Drug Carriers; D016503:Drug Delivery Systems; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D019344:Lactic Acid; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry*; D015032:Zinc
chemical_list: D000464:Alginates; D002214:Capsules; D004337:Drug Carriers; D006603:Hexuronic Acids; D010455:Peptides; D011108:Polymers; D011506:Proteins; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D020723:Glucuronic Acid; D048271:Chitosan; D015032:Zinc