title: [Histological changes in the rabbit kidney induced by transarterial injection of a hypertonic sodium chloride solution].
abstract: OBJECTIVE
  To evaluate histological changes in normal renal tissue induced by the injection of a hypertonic liquid.
  
  
  METHODS
  Transarterial injection was performed in 17 healthy rabbits at various rates of infusion and amounts of isotonic and hypertonic (7%) sodium chloride solutions. In group 1, 10 cc of isotonic sodium chloride solution was injected. In groups 2 and 3, 1-10 cc of hypertonic solution was injected at rates of 1.0 cc/sec and 0.05 cc/sec, respectively. After 20 minutes of hemostasis, renal weight measurements and histological examinations were performed. In three rabbits that received 10 cc of 7% sodium chloride, lung samples were also obtained, and histological changes were reviewed.
  
  
  RESULTS
  There was no tissue injury in group 1, and in groups 2 and 3 the histological changes for infusions of 4-10 cc were greater than those of 1-3 cc. There was no vascular endothelial cell damage in any case. None of the histological changes were dose dependent, and the lungs showed no clear histological alterations.
  
  
  CONCLUSIONS
  Higher doses of a hypertonic sodium chloride solution cause irreversible histological changes in the rabbit kidney.
authors.affiliation: Department of Radiology, Saitama Medical School.
authors.forename: Kenzo
authors.initials: K
authors.lastname: Okauchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishizaka
authors.forename: Akihisa
authors.initials: A
authors.lastname: Shiraishi
authors.forename: Takanori
authors.initials: T
authors.lastname: Hirose
authors.forename: Atsuko
authors.initials: A
authors.lastname: Heshiki
mesh_terms: D000818:Animals; D007267:Injections; D007668:Kidney / Q000166:cytology / Q000187:drug effects*; D011817:Rabbits; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D012462:Saline Solution, Hypertonic