[Expression of MUC5AC in human nasal polyp and inferior turbinate epithelium].
OBJECTIVE
To examine the expression of MUC5AC in human nasal polyp and inferior turbinate epithelium, to evaluate the relationship between MUC5AC and the increased mucous secretions in polyps and chronic hypertrophy rhinitis.


METHODS
With immunohistochemistry ABC and HE dyeing, twenty-seven polyps, nineteen chronic hypertrophy rhinitis and eleven normal inferior turbinates epithelium were applied to this study.


RESULTS
The number of MUC5AC+ cells in nasal polyps and chronic hypertrophy rhinitis was significantly bigger than that in normal inferior turbinates (P < 0.05), and the MUC5AC+ cells were mainly concentrate on the goblet cells.


CONCLUSIONS
MUC5AC is highly expressed in epithelium of human polyps and chronic hypertrophy rhinitis inferior turbinates, and MUC5AC takes part in increasing secretion in polyps and chronic hypertrophy rhinitis.
Lü
Haili
H
Department of Otolaryngology-Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130031, China.
Guo
Yongqing
Y
Dong
Zhen
Z
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC; D009077:Mucins / Q000096:biosynthesis*; D009297:Nasal Mucosa / Q000378:metabolism*; D009298:Nasal Polyps / Q000378:metabolism*; D012220:Rhinitis / Q000378:metabolism; D014420:Turbinates / Q000378:metabolism*
C524678:MUC5AC protein, human; D055271:Mucin 5AC; D009077:Mucins