Measuring reaction kinetics in a lab-on-a-chip by microcoil NMR.
A microfluidic chip with an integrated planar microcoil was developed for Nuclear Magnetic Resonance (NMR) spectroscopy on samples with volumes of less than a microliter. Real-time monitoring of imine formation from benzaldehyde and aniline in the microreactor chip by NMR was demonstrated. The reaction times in the chip can be set from 30 min down to ca. 2 s, the latter being the mixing time in the microfluidic chip. Design rules will be described to optimize the microreactor and detection coil in order to deal with the inherent sensitivity of NMR and to minimize magnetic field inhomogeneities and obtain sufficient spectral resolution.
Wensink
Henk
H
BIOS, the Lab-on-a-Chip group, MESA+ Research Institute, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Benito-Lopez
Fernando
F
Hermes
Dorothee C
DC
Verboom
Willem
W
Gardeniers
Han J G E
HJ
Reinhoudt
David N
DN
van den Berg
Albert
A
D007097:Imines / Q000737:chemistry*; D007700:Kinetics; D056656:Lab-On-A-Chip Devices; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation* / Q000379:methods*; D046208:Microchip Analytical Procedures / Q000379:methods*; D012680:Sensitivity and Specificity; D013997:Time Factors
D007097:Imines