Nature-nurture interplay: genetically informative designs contribute to understanding the effects of trauma and interpersonal violence.
The past two decades have seen an explosion in research in the fields of violence and trauma and behavior genetics. These two fields came into direct conflict when Lisabeth Fisher DiLalla and Irving I. Gottesman outlined a fundamental conceptual limitation of trauma and violence research: that rather than being causal, the well-documented relationship between exposure to trauma or violence and later negative outcomes could be explained by gene-environment correlation. In the past decade, researchers have addressed this limitation by studying the effects of trauma and violence using genetically informative designs. This report briefly discusses the gains made from this research approach and the promising future for genetically informative trauma and violence research.
Koenen
Karestan C
KC
Harvard School of Public Health, Department of Society, Human Development, and Health, Boston, MA 02115, USA. kkoenen@hsph.harvard.edu
D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008960:Models, Psychological; D012107:Research Design / Q000592:standards; D012307:Risk Factors; D012742:Sex Offenses / Q000517:prevention & control / Q000523:psychology; D012747:Sexual Partners / Q000523:psychology; D012931:Social Environment; D013179:Spouse Abuse / Q000517:prevention & control / Q000523:psychology; D013313:Stress Disorders, Post-Traumatic / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D014481:United States
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