Preclinical perspectives on the use of platinum compounds in cancer chemotherapy.
Although platinum compounds have long been used in cancer chemotherapy, understanding the biochemistry and specific activity of these agents remains a focus of ongoing research, particularly with regard to next-generation platinum agents. This review will examine current knowledge and recent studies of the molecular mechanisms of platinum DNA damage and repair, including novel platinum DNA targets. Gene expression associated with platinum DNA damage will also be explored, as well as mechanisms of platinum-drug delivery, drug resistance, and future directions in the development of novel platinum agents.
Farrell
Nicholas P
NP
Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA. nfarrell@mail1.vcu.edu <nfarrell@mail1.vcu.edu>
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018736:DNA Adducts; D004249:DNA Damage; D004260:DNA Repair; D016503:Drug Delivery Systems; D019008:Drug Resistance, Neoplasm; D015870:Gene Expression; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics; D017671:Platinum Compounds / Q000494:pharmacology* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D018736:DNA Adducts; D017671:Platinum Compounds