title: [Study on differential diagnosis between MALT-type lymphoma and reactive lymphoid hyperplasia of the ocular adnexa].
abstract: OBJECTIVE
  To study the methods of differential diagnosis between mucosa-associated lymphoid tissue (MALT) type lymphoma and reactive lymphoid hyperplasia in ocular adnexa.
  
  
  METHODS
  The clinical, morphologic, immunohistochemical, and molecular biologic (polymerase chain reaction [PCR]) studies were performed on 29 patients with MALT-type lymphoma and 8 patients with reactive lymphoid hyperplasia of the ocular adnexa.
  
  
  RESULTS
  29 cases with MALT-type lymphoma expressed B-cell markers and but T-cell makers, whereas 8 cases of reactive lymphoid hyperplasia all expressed B and T cell markers and the positive rate of T-cell marker was up to 30%. immunohistochemistry staining showed 11 cases were positive for immunoglobin light chain (kappa or lambda), however it was positive in one chain of the immunoglobin in 15 cases of MALT type lymphoma by PCR. No significant difference in the clinical characteristics was observed between the MALT type lymphoma and reactive lymphoid hyperplasia in ocular adnexa.
  
  
  CONCLUSIONS
  Immunohistochemical analysis and PCR are helpful in confirming the diagnosis between the MALT-lymphoma and the reactive lymphoid hyperplasia.
authors.affiliation: Department of Ophthalmology, Armed Police General Hospital, Beijing 100039, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Xiao
authors.forename: Yan-jin
authors.initials: YJ
authors.lastname: He
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Zi-fen
authors.initials: ZF
authors.lastname: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009916:Orbital Diseases / Q000175:diagnosis* / Q000473:pathology; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016133:Polymerase Chain Reaction; D019310:Pseudolymphoma / Q000175:diagnosis* / Q000473:pathology