Two cases of antinuclear antibody negative lupus showing increased proportion of B cells lacking RP105.
B cells lacking RP105 molecule, a member of the Toll-like receptor family, were increased in the peripheral blood of 2 patients with antinuclear antibody (ANA) negative systemic lupus erythematosus (SLE). The increased proportion of RP105-lacking B cells was associated with disease activity in patients with ANA-negative SLE. When there are no significant serological markers for SLE, analysis of expression of RP105 may be helpful in evaluation of activity in ANA-negative SLE. We describe a new approach, using phenotyping of B cells, to evaluate activity of ANA-negative SLE.
Koarada
Syuichi
S
Division of Rheumatology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan. koarad@post.saga-med.ac.jp
Ide
Masaru
M
Haruta
Yoshio
Y
Tada
Yoshifumi
Y
Ushiyama
Osamu
O
Morito
Fumitaka
F
Ohta
Akihide
A
Nagasawa
Kohei
K
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood / Q000276:immunology*; D015703:Antigens, CD / Q000097:blood / Q000276:immunology*; D001402:B-Lymphocytes / Q000378:metabolism*; D015415:Biomarkers; D001921:Brain / Q000276:immunology / Q000473:pathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D008297:Male
D000974:Antibodies, Antinuclear; D015703:Antigens, CD; D015415:Biomarkers; C092722:CD180 protein, human