title: Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).
abstract: A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC50 values as low as 130 nM and suppress the expression of TNFalpha in U937 cells. These represent the first small molecule inhibitors of MK-2 to be reported.
authors.affiliation: Pfizer Global Research and Development, 700 Chesterfield Parkway W, Chesterfield, MO 63017, USA. david.r.anderson@pfizer.com
authors.forename: David R
authors.initials: DR
authors.lastname: Anderson
authors.forename: Shridhar
authors.initials: S
authors.lastname: Hegde
authors.forename: Emily
authors.initials: E
authors.lastname: Reinhard
authors.forename: Leslie
authors.initials: L
authors.lastname: Gomez
authors.forename: William F
authors.initials: WF
authors.lastname: Vernier
authors.forename: Len
authors.initials: L
authors.lastname: Lee
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
authors.forename: Aruna
authors.initials: A
authors.lastname: Sambandam
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Snider
authors.forename: Liaqat
authors.initials: L
authors.lastname: Masih
mesh_terms: D000818:Animals; D015870:Gene Expression; D006801:Humans; D048370:MAP Kinase Kinase 2 / Q000037:antagonists & inhibitors*; D008956:Models, Chemical; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D020298:U937 Cells
chemical_list: D011725:Pyridines; D014409:Tumor Necrosis Factor-alpha; D048370:MAP Kinase Kinase 2