title: Inhaled nitric oxide treatment of patients with pulmonary tuberculosis evidenced by positive sputum smears.
abstract: Endogenous nitric oxide (NO) has antimycobacterial properties. We tested the hypothesis that exogenous (inhaled) NO can be safely delivered and can accelerate airway disinfection for pulmonary tuberculosis patients treated with standard therapy. Exogenous NO administered at 80 ppm for 72 h can be safely delivered but does not accelerate airway disinfection.
authors.affiliation: Department of Medicine, University of Alberta, Room 8325, Aberhart Centre 1, 11402, University Ave., Edmonton, Alberta T6G 2J3, Canada. richard.long@ualberta.ca
authors.forename: Richard
authors.initials: R
authors.lastname: Long
authors.forename: Richard
authors.initials: R
authors.lastname: Jones
authors.forename: James
authors.initials: J
authors.lastname: Talbot
authors.forename: Irvin
authors.initials: I
authors.lastname: Mayers
authors.forename: James
authors.initials: J
authors.lastname: Barrie
authors.forename: Michael
authors.initials: M
authors.lastname: Hoskinson
authors.forename: Bruce
authors.initials: B
authors.lastname: Light
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D009569:Nitric Oxide / Q000008:administration & dosage*; D013183:Sputum / Q000382:microbiology*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D009569:Nitric Oxide
references.citation: Am J Respir Cell Mol Biol. 2001 Nov;25(5):606-12
references.pmid: 11713103
references.citation: Am J Respir Crit Care Med. 2003 Feb 15;167(4):603-62
references.pmid: 12588714
references.citation: Infect Immun. 2003 Dec;71(12):7099-108
references.pmid: 14638800
references.citation: Infect Control Hosp Epidemiol. 2003 Nov;24(11):831-8
references.pmid: 14649771
references.citation: Tubercle. 1976 Dec;57(4):251-8
references.pmid: 827836
references.citation: Am Rev Respir Dis. 1980 Jun;121(6):939-49
references.pmid: 6774638
references.citation: Antimicrob Agents Chemother. 1999 Feb;43(2):403-5
references.pmid: 9925545
references.citation: Kidney Int. 1994 Mar;45(3):737-42
references.pmid: 7515129
references.citation: Infect Immun. 1995 Feb;63(2):736-40
references.pmid: 7529749
references.citation: N Engl J Med. 1997 Feb 27;336(9):597-604
references.pmid: 9036320
references.citation: N Engl J Med. 1997 Feb 27;336(9):605-10
references.pmid: 9032045
references.citation: Can J Cardiol. 1997 Sep;13(9):816-24
references.pmid: 9343030
references.citation: Chest. 1998 Feb;113(2):379-86
references.pmid: 9498955
references.citation: J Exp Med. 1992 Apr 1;175(4):1111-22
references.pmid: 1552282