title: Multicenter study of the safety and efficacy of a 585 nm pulsed-dye laser for the nonablative treatment of facial rhytides.
abstract: OBJECTIVE
  The objective of this study was to assess the safety and efficacy of a 585 nm flashlamp pulsed-dye laser for the nonablative treatment of facial rhytides.
  
  
  METHODS
  A multicenter prospective randomized controlled study on 58 volunteers was performed. A split-face approach was adopted, with one periorbital region acting as a control and the other receiving either one or two treatments. Patients were photographed and imaged three-dimensionally before and after treatment. Histologic sections were analyzed.
  
  
  RESULTS
  Three-dimensional topographic evaluation showed improvements of 9.8% (p = .0022) and 15% (p = .0029) in surface roughness for single and double treatments, respectively. Histology revealed an increase in type I collagen messenger ribonucleic acid expression, type III procollagen, chondroitin sulfate, and grenz zone thickness. Two treatments resulted in greater improvement than one treatment.
  
  
  CONCLUSIONS
  Clinical improvement was achieved following a single treatment. Further improvement was observed following a second treatment. The subjective evaluation of clinical improvement was consistent with both histologic and topographic quantitative measurements.
authors.affiliation: thsu@skincarephysicians.net
authors.forename: T S Jeffrey
authors.initials: TS
authors.lastname: Hsu
authors.forename: Brian
authors.initials: B
authors.lastname: Zelickson
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Dover
authors.forename: Suzanne
authors.initials: S
authors.lastname: Kilmer
authors.forename: Jay
authors.initials: J
authors.lastname: Burns
authors.forename: George
authors.initials: G
authors.lastname: Hruza
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Brown
authors.forename: Eric F
authors.initials: EF
authors.lastname: Bernstein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D015361:Rhytidoplasty / Q000379:methods*; D015595:Skin Aging; D018709:Statistics, Nonparametric; D016896:Treatment Outcome