Subdural recordings of the mismatch negativity (MMN) in patients with focal epilepsy.
Mismatch negativity (MMN) is elicited by discernible changes in an otherwise regular stream of auditory stimulation and reflects a pre-attentive detection mechanism. In the current study, auditory evoked potentials were recorded intracranially and electrode contacts sensitive for stimulus deviance were selected in order to further elucidate the contribution of different brain areas to MMN generation. Data were obtained from patients with frontal and temporal lobe epilepsy undergoing a presurgical evaluation by subdural and depth electrodes. In 13 of 29 patients under investigation an intracranial MMN could be observed, while in four other patients a response recovery of the N100 was revealed, mimicking an MMN. Most electrodes with an MMN signal were located in or close to the superior temporal lobe. In two patients an MMN was observed at electrode contacts over the lateral inferior frontal cortex and in one patient at a frontal interhemispheric electrode strip, giving evidence for a participation of the frontal gyrus in MMN generation. Current findings have, however, to be interpreted with caution owing to the placement and limited extension of the used electrode arrays.
Rosburg
Timm
T
Department of Epileptology, University of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany. timm.rosburg@ukb.uni-bonn.de
Trautner
Peter
P
Dietl
Thomas
T
Korzyukov
Oleg A
OA
Boutros
Nashaat N
NN
Schaller
Carlo
C
Elger
Christian Erich
CE
Kurthen
Martin
M
D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D000328:Adult; D016477:Artifacts; D001307:Auditory Perception; D001931:Brain Mapping / Q000379:methods; D004567:Electrodes, Implanted; D004828:Epilepsies, Partial / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D017034:Epilepsy, Frontal Lobe / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged