title: Gut permeability and intestinal mucins, invertase, and peroxidase in control and diabetes-prone BB rats fed either a protective or a diabetogenic diet.
abstract: This study deals with the enteropathy recently identified in diabetes-prone BB rats (BBdp). Diabetes-resistant BB rats (BBc) and BBdp rats were fed from days 32-39 onward either a protective diabetes-retardant hydrolyzed casein diet (HC) or a plant-based diabetogenic (NTP) diet. The NTP diet decreased body weight and plasma insulin in BBc and BBdp rats. The BBdp rats displayed low intestinal invertase and increased intestinal peroxidase activity. In the BBdp rats fed the HC diet, the mucin content 30-35 cm below the pylorus was higher and the gut permeability lower than in the other three rat groups. There was a significant inverse correlation between gut permeability and the insulinogenic index in the BBdp rats fed the HC or NTP diet. Thus, in BBdp rats, the HC diet somehow prevents the increase in gut permeability and the decrease in the insulinogenic index otherwise found in some of these diabetes-prone animals.
authors.affiliation: Laboratory of Experimental Hormonology, Brussels Free University, Belgium.
authors.forename: Philippe
authors.initials: P
authors.lastname: Courtois
authors.forename: Gisèle
authors.initials: G
authors.lastname: Nsimba
authors.forename: Hassan
authors.initials: H
authors.lastname: Jijakli
authors.forename: Abdullah
authors.initials: A
authors.lastname: Sener
authors.forename: Fraser W
authors.initials: FW
authors.lastname: Scott
authors.forename: Willy J
authors.initials: WJ
authors.lastname: Malaisse
mesh_terms: D000818:Animals; D002364:Caseins; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004032:Diet; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000201:enzymology; D008297:Male; D009077:Mucins / Q000032:analysis*; D009929:Organ Size; D010179:Pancreas / Q000503:physiopathology; D010539:Permeability; D009195:Peroxidase / Q000032:analysis*; D051381:Rats; D011913:Rats, Inbred BB; D043324:beta-Fructofuranosidase / Q000032:analysis*
chemical_list: D002364:Caseins; D009077:Mucins; D009195:Peroxidase; D043324:beta-Fructofuranosidase
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