title: Optical coherence tomography: a new method to assess aneurysm healing.
abstract: OBJECTIVE
  Aneurysmal subarachnoid hemorrhage affects approximately 10/100,000 people per year. Endovascular coil embolization is used increasingly to treat cerebral aneurysms and its safety and durability is rapidly developing. The long-term durability of coil embolization of cerebral aneurysms remains in question; patients treated using this modality require multiple follow-up angiography studies and occasional repeated treatments.
  
  
  METHODS
  Optical coherence tomography (OCT) is an emerging imaging modality that uses backscattered light to produce high-resolution tomography of optically accessible biological tissues such as the eye, luminal surface of blood vessels, and gastrointestinal tract. Vascular OCT probes in the form of imaging microwires are presently available--although not Food and Drug Administration-approved--and may be adapted for use in the cerebral circulation. In this study the authors describe the initial use of OCT to make visible the neck of aneurysms created in a canine model and treated with coil embolization. Optical coherence tomography images demonstrate changes that correlate with the histological findings of healing at the aneurysm neck and thus may be capable of demonstrating human cerebral aneurysm healing.
  
  
  CONCLUSIONS
  Optical coherence tomography may obviate the need for subsequent follow-up angiography studies as well as aid in the understanding of endovascular tissue healing. Data in this study demonstrate that further investigation of in vivo imaging with such probes is warranted.
authors.affiliation: Department of Neurosurgery, Cole Eye Institute, Cleveland Clinic Foundation 44195, USA.
authors.forename: William E
authors.initials: WE
authors.lastname: Thorell
authors.forename: Michael M
authors.initials: MM
authors.lastname: Chow
authors.forename: Richard A
authors.initials: RA
authors.lastname: Prayson
authors.forename: Mark A
authors.initials: MA
authors.lastname: Shure
authors.forename: Sung W
authors.initials: SW
authors.lastname: Jeon
authors.forename: David
authors.initials: D
authors.lastname: Huang
authors.forename: Emil
authors.initials: E
authors.lastname: Zeynalov
authors.forename: Henry H
authors.initials: HH
authors.lastname: Woo
authors.forename: Peter A
authors.initials: PA
authors.lastname: Rasmussen
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Rollins
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Masaryk
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000473:pathology; D002340:Carotid Artery Diseases / Q000473:pathology / Q000628:therapy; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000473:pathology; D004195:Disease Models, Animal; D004285:Dogs; D004621:Embolization, Therapeutic; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D002532:Intracranial Aneurysm / Q000473:pathology* / Q000628:therapy; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
references.citation: J Neurosurg. 1991 Jul;75(1):1-7
references.pmid: 2045891
references.citation: Neuroradiology. 1997 Apr;39(4):286-91
references.pmid: 9144679
references.citation: AJNR Am J Neuroradiol. 2003 Apr;24(4):579-84
references.pmid: 12695184
references.citation: J Neurosurg. 2001 Mar;94(3):454-63
references.pmid: 11235951
references.citation: Acad Radiol. 2002 Aug;9(8):942-53
references.pmid: 12186444
references.citation: Neuroradiology. 2001 Aug;43(8):680-6
references.pmid: 11548178
references.citation: J Am Coll Cardiol. 2002 Feb 20;39(4):604-9
references.pmid: 11849858
references.citation: AJNR Am J Neuroradiol. 1998 Aug;19(7):1183-4
references.pmid: 9726448
references.citation: Radiologe. 1999 Oct;39(10):900-3
references.pmid: 10550391
references.citation: J Neurosurg. 1999 Aug;91(2):284-93
references.pmid: 10433317
references.citation: AJNR Am J Neuroradiol. 1992 Jul-Aug;13(4):1089-95
references.pmid: 1636518
references.citation: AJNR Am J Neuroradiol. 2002 Feb;23(2):288-94
references.pmid: 11847057
references.citation: AJNR Am J Neuroradiol. 1996 Aug;17(7):1333-7
references.pmid: 8871720
references.citation: AJNR Am J Neuroradiol. 1993 Jul-Aug;14(4):787-93
references.pmid: 8352144
references.citation: Science. 1991 Nov 22;254(5035):1178-81
references.pmid: 1957169
references.citation: AJNR Am J Neuroradiol. 2000 Sep;21(8):1523-31
references.pmid: 11003290
references.citation: J Neurosurg. 1991 Jul;75(1):8-14
references.pmid: 2045924
references.citation: JAMA. 1981 Aug 21;246(8):880
references.pmid: 7019469
references.citation: AJNR Am J Neuroradiol. 1997 Feb;18(2):279-86
references.pmid: 9111664
references.citation: Circulation. 2001 Nov 27;104(22):2754
references.pmid: 11723031
references.citation: Am J Cardiol. 1996 Jan 1;77(1):92-3
references.pmid: 8540467
references.citation: Neurochirurgie. 1998 Apr;44(2):105-10
references.pmid: 9757342
references.citation: Confin Neurol. 1969;31(1):94
references.pmid: 4900494
references.citation: Circulation. 1996 Dec 1;94(11):3013
references.pmid: 8941150
references.citation: AJNR Am J Neuroradiol. 1990 Mar-Apr;11(2):249-52
references.pmid: 2107707
references.citation: Surg Neurol. 1990 Feb;33(2):157-8
references.pmid: 2305362
references.citation: J Neurosurg. 1974 Dec;41(6):657-70
references.pmid: 4609023
references.citation: J Neurosurg. 1970 Oct;33(4):422-7
references.pmid: 5471931
references.citation: Surg Neurol. 1990 Dec;34(6):361-5
references.pmid: 2244298
references.citation: Circulation. 2002 Sep 24;106(13):1640-5
references.pmid: 12270856
references.citation: AJNR Am J Neuroradiol. 1993 Jul-Aug;14(4):801-3
references.pmid: 8352147
references.citation: J Neurosurg. 1974 Aug;41(2):125-45
references.pmid: 4841872
references.citation: AJNR Am J Neuroradiol. 2001 Oct;22(9):1750-6
references.pmid: 11673173
references.citation: Heart. 1999 Aug;82(2):128-33
references.pmid: 10409522
references.citation: Lancet. 2002 Oct 26;360(9342):1267-74
references.pmid: 12414200
references.citation: AJNR Am J Neuroradiol. 1999 Aug;20(7):1301-8
references.pmid: 10472990
references.citation: J Neurosurg. 1965 Jun;22(6):539-47
references.pmid: 5832773
references.citation: Opt Lett. 1995 Nov 1;20(21):2258
references.pmid: 19862316