title: [Clear cell tumor of the lung].
abstract: Clear cell tumors of the lung are rare tumors composed of epithelioid HMB45 positive tumor cells. It has been proposed that clear cell tumors generate from perivascular epithelioid cells which are also found in renal angiomyolipoma. Due to its morphologic epithelioid features with clear cytoplasm the distinction from either primary or metastatic clear cell carcinoma is difficult. Usually clinical investigations do not lead to the final diagnosis so that only subsequent histological examination and immunophenotyping can establish the correct tumor classification. We describe the case of a 52 year old woman who underwent exploratory thoracotomy because of a lung mass in the right lower lobe. In frozen sections a solid trabecular tumor was diagnosed, paraffin histology and immunohistochemistry revealed a clear cell tumor of the lung. The difficulty of the correct diagnosis of the clear cell tumor of the lung in frozen sections is discussed as well as the differential diagnosis.
authors.affiliation: Institut für Pathologie, Universität Köln. u.drebber@uni-koeln.de
authors.forename: U
authors.initials: U
authors.lastname: Drebber
authors.forename: M
authors.initials: M
authors.lastname: Ortmann
authors.forename: H U
authors.initials: HU
authors.lastname: Kasper
authors.forename: M A
authors.initials: MA
authors.lastname: Kern
authors.forename: U M
authors.initials: UM
authors.lastname: Fischer
authors.forename: A T
authors.initials: AT
authors.lastname: Nemat
authors.forename: H P
authors.initials: HP
authors.lastname: Dienes
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
references.citation: Pathology. 1994 Jul;26(3):230-6
references.pmid: 7991275
references.citation: Am J Surg Pathol. 1992 Mar;16(3):307-8
references.pmid: 1599021
references.citation: Kyobu Geka. 1996 Apr;49(4):337-40
references.pmid: 8721372
references.citation: Arch Pathol Lab Med. 1988 Dec;112(12):1177-8
references.pmid: 3190399
references.citation: Lung Cancer. 1993 Oct;10(1-2):101-6
references.pmid: 8069598
references.citation: Acta Pathol Jpn. 1988 Apr;38(4):515-22
references.pmid: 3400469
references.citation: Am J Surg Pathol. 2002 May;26(5):670-5
references.pmid: 11979098
references.citation: Am J Surg Pathol. 1997 Oct;21(10):1242-7
references.pmid: 9331299
references.citation: Am J Surg Pathol. 1991 Feb;15(2):199-202
references.pmid: 2025321
references.citation: Arch Pathol Lab Med. 1991 Oct;115(10):1034-8
references.pmid: 1898230
references.citation: Semin Diagn Pathol. 1997 Nov;14(4):222-32
references.pmid: 9383822
references.citation: Pneumonol Alergol Pol. 2000;68(1-2):60-4
references.pmid: 10967903
references.citation: Am J Surg Pathol. 1990 Mar;14(3):248-59
references.pmid: 1689555
references.citation: Cancer. 1974 May;33(5):1328-36
references.pmid: 4362953
references.citation: Cancer. 1971 Mar;27(3):712-9
references.pmid: 4323616
references.citation: Yale J Biol Med. 1971 Feb-Apr;43(4-5):213-22
references.pmid: 5578741
references.citation: Arch Pathol Lab Med. 1986 Jul;110(7):664-6
references.pmid: 3755031
references.citation: Am J Surg Pathol. 1996 Jun;20(6):722-30
references.pmid: 8651352
references.citation: Radiology. 1978 Dec;129(3):595-6
references.pmid: 725030
references.citation: Cancer. 1985 Dec 1;56(11):2657-63
references.pmid: 4052941