William M. Feinberg Lecture: Cognitive vitality and the role of stroke and cardiovascular disease risk factors.
OBJECTIVE
Vascular risk factors are common in the elderly, and some such as hypertension may be important predictors of cognitive impairment.


RESULTS
In this article, the role that vascular risk factors may play in the prevention of vascular and nonvascular forms of cognitive impairment is reviewed.


CONCLUSIONS
Because vascular risk factors may have negative effects on brain structure and cognitive function, and because vascular risk factors may be present in midlife or possibly earlier, we may need to develop long-term intervention strategies to control or prevent vascular risk factors in an effort to preserve cognitive vitality as we age.
Gorelick
Philip B
PB
Department of Neurology and Rehabilitation, University of Illinois College of Medicine at Chicago, Chicago, Ill 60612, USA. pgorelic@uic.edu
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000544:Alzheimer Disease / Q000175:diagnosis; D001921:Brain / Q000473:pathology; D002318:Cardiovascular Diseases / Q000150:complications / Q000175:diagnosis*; D003072:Cognition Disorders / Q000150:complications / Q000209:etiology*; D015140:Dementia, Vascular / Q000175:diagnosis; D006801:Humans; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis* / Q000473:pathology; D014652:Vascular Diseases / Q000150:complications