Pharmacogenetics of anesthetic and analgesic agents.
Predicting a patient's response to a particular drug has long been a goal of clinicians. Rapid advances in molecular biology have enabled researchers to identify associations between an individual's genetic profile and drug response. Pharmacogenetics is the study of the molecular mechanisms that underlie individual differences in drug metabolism, efficacy, and side effects. The pharmacogenetics of commonly used anesthetic and analgesic agents are reviewed.
Palmer
Stephen N
SN
Department of Cardiovascular Anesthesia, Texas Heart Institute, St. Luke's Episcopal Hospital, Houston 77030, USA.
Giesecke
N Martin
NM
Body
Simon C
SC
Shernan
Stanton K
SK
Fox
Amanda A
AA
Collard
Charles D
CD
D000700:Analgesics / Q000378:metabolism / Q000494:pharmacology*; D000777:Anesthetics / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D009294:Narcotics / Q000378:metabolism / Q000494:pharmacology; D009466:Neuromuscular Blocking Agents / Q000378:metabolism / Q000494:pharmacology; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic
D000700:Analgesics; D000777:Anesthetics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009294:Narcotics; D009466:Neuromuscular Blocking Agents