title: Novel polyelectrolyte carboxymethyl konjac glucomannan-chitosan nanoparticles for drug delivery. I. Physicochemical characterization of the carboxymethyl konjac glucomannan-chitosan nanoparticles.
abstract: Carboxymethyl konjac glucomannan-chitosan (CKGM-CS) nanoparticles, which are well dispersed and stable in aqueous solution, were spontaneously prepared under very mild conditions via polyelectrolyte complexation. The physicochemical properties of the nanoparticles were identified by Zetasizer 3000 and Fourier transform infrared. It was found that at various CKGM and CS concentrations the particles ranged in size from approximately 50 to 1200 nm, and the zeta potential from 15 to 45 mV. By changing pH value of the medium and increasing the concentration of salt, the mean size of the particles increased and the zeta potential decreased. Also, investigations on the encapsulation efficiency of the bovine serum albumin loaded CKGM-CS nanoparticles were also undertaken. This nanoparticulate system driven by complex formation shows potential as an advanced drug delivery system for water-soluble drugs.
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Du
authors.forename: Rui
authors.initials: R
authors.lastname: Sun
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.forename: Li-Fang
authors.initials: LF
authors.lastname: Zhang
authors.forename: Cheng-Dong
authors.initials: CD
authors.lastname: Xiong
authors.forename: Yu-Xing
authors.initials: YX
authors.lastname: Peng
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D004573:Electrolytes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008351:Mannans / Q000737:chemistry*; D015394:Molecular Structure; D008970:Molecular Weight; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014783:Viscosity
chemical_list: D004573:Electrolytes; D008351:Mannans; D012710:Serum Albumin, Bovine; C022901:(1-6)-alpha-glucomannan; D048271:Chitosan