title: Comparison of unmonochromatized synchrotron radiation and conventional X-rays in the imaging of mammographic phantom and human breast specimens: a preliminary result.
abstract: A simple imaging setup based on the principle of coherence-based contrast X-ray imaging with unmonochromatized synchrotron radiation was used for studying mammographic phantom and human breast specimens. The use of unmonochromatized synchrotron radiation simplifies the instrumentation, decreases the cost and makes the procedure simpler and potentially more suitable for clinical applications. The imaging systems consisted of changeable silicon wafer attenuators, a tungsten slit system, a CdWO4 scintillator screen, a CCD (Charge Coupled Device) camera coupled to optical magnification lenses, and a personal computer. In preliminary studies, a spatial resolution test pattern and glass capillary filled with air bubbles were imaged to evaluate the resOolution characteristics and coherence-based contrast enhancement. Both the spatial resolution and image quality of the proposed system were compared with those of a conventional mammography system in order to establish the characteristic advantages of this approach. The images obtained with the proposed system showed a resolution of at least 25 microm on the test pattern with much better contrast, while the images of the capillary filled with air bubbles revealed coherence-based edge enhancement. This result shows that the coherence-based contrast imaging system, which emphasizes the refraction effect from the edge of materials of different refractive indexes, is applicable to imaging studies in fundamental medicine and biology, although further research works will be required before it can be used for clinical applications.
authors.affiliation: Department of Diagnostic Radiology, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemoon-gu, Seoul 120-752, Korea.
authors.forename: Haijo
authors.initials: H
authors.lastname: Jung
authors.forename: Hee-Joung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Kim
authors.forename: Jin-O
authors.initials: JO
authors.lastname: Hong
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Je
authors.forename: Yeukuang
authors.initials: Y
authors.lastname: Hwu
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Tsai
authors.forename: Giorgio
authors.initials: G
authors.lastname: Magaritondo
authors.forename: Hyung-Sik
authors.initials: HS
authors.lastname: Yoo
mesh_terms: D001941:Breast Diseases / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008327:Mammography / Q000295:instrumentation* / Q000379:methods*; D019047:Phantoms, Imaging; D010865:Pilot Projects; D017356:Synchrotrons; D014965:X-Rays
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