title: [Antifungal susceptibility of Candida species causing candidemia in Kurume University Hospital and Shaiseikai Hutukaichi Hospital].
abstract: Prevention of candidemia has been difficult and empirical therapy may eventually reduce morbidity and mortality. Successful empirical therapies depend on understanding of fungal features and antifungal agents. Susceptibility to amphotericin B (AMPH-B), flucytosine (5-FC), fluconazole (FLCZ), itraconazole (ITCZ), miconazole (MCZ), and micafungin (MCFG) of 41 Candida species isolated from blood were determined. Candida albicans was the most common species (23 species), followed by C. parapsilosis (5 species), C. tropicalis (4 species), C. glabrata (3 species), C. guilliermondii (2 species), C. krusei (1 specie), and Candida spp (3 species). The isolation rates of the drug-resistant (DR) fungi were 5% for 5-FC. The rates of DR and susceptible dose dependent (S-DD) fungi were 0% and 2% for FLCZ, respectively. The rates of DR and S-DD fungi were 0% and 17% for ITCZ, respectively. No shift to resistant species in C. albicans occurred in our hospitals. All C. albicans were susceptible for the antifungal agents examined.
authors.affiliation: Shaiseikai Hutukaichi Hospital.
authors.forename: Toru
authors.initials: T
authors.lastname: Rikimaru
authors.forename: Junko
authors.initials: J
authors.lastname: Yonemitu
authors.forename: Akiko
authors.initials: A
authors.lastname: Shimada
authors.forename: Ako
authors.initials: A
authors.lastname: Koga
authors.forename: Mamoru
authors.initials: M
authors.lastname: Nishiyama
authors.forename: Kouji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Chiyoko
authors.initials: C
authors.lastname: Tanamachi
authors.forename: Kiminori
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Kimitaka
authors.initials: K
authors.lastname: Sagawa
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Aizawa
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D016469:Fungemia / Q000382:microbiology*; D006801:Humans
chemical_list: D000935:Antifungal Agents