title: Feasibility study of the use of similarity maps in the evaluation of oncological dynamic positron emission tomography images.
abstract: A preliminary study is presented on the potential role of similarity mapping (SM) in the evaluation of oncological dynamic 18F-fluorodeoxyglucose positron emission tomography studies, mainly in lesion localisation and detectability. Similarity maps were calculated using previously described (correlation coefficient (COR) and normalised correlation coefficient (NCOR)) and newly introduced similarity measures (sum of squares coefficient (SSQ), squared sum coefficient (SQS), sum of cubes coefficient (SC) and cubed sum coefficient (CS)). The results were evaluated using simulated and clinical data. The study revealed that the best-suited similarity measure for such applications was the CS similarity coefficient, which provided the best parametric images, delineating structures of interest and supporting the visual interpretation of data sets. It was shown that SM and standardised uptake value (SUV) images had comparable diagnostic performance, although SM was able to offer additional time-related information in a single image. For the case of colorectal recurrences (17 cases), the measured contrast values for the CS and SUV images were 2.36 +/- 0.47 and 4.12 +/- 0.42, respectively, whereas, for three cases of giant cell tumours, these values were 11.6 +/- 2.1 and 11.9 +/- 1.8, respectively.
authors.affiliation: Biomedical Engineering Laboratory, National Technical University of Athens, Athens, Greece.
authors.forename: T
authors.initials: T
authors.lastname: Thireou
authors.forename: G
authors.initials: G
authors.lastname: Kontaxakis
authors.forename: L G
authors.initials: LG
authors.lastname: Strauss
authors.forename: A
authors.initials: A
authors.lastname: Dimitrakopoulou-Strauss
authors.forename: S
authors.initials: S
authors.lastname: Pavlopoulos
authors.forename: A
authors.initials: A
authors.lastname: Santos
mesh_terms: D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging; D005240:Feasibility Studies; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D009369:Neoplasms / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
references.citation: Acta Radiol. 1994 Jul;35(4):371-7
references.pmid: 8011388
references.citation: Comput Med Imaging Graph. 1999 Jul-Aug;23 (4):181-91
references.pmid: 10551724
references.citation: Nucl Med Biol. 2000 Oct;27(7):643-6
references.pmid: 11091106
references.citation: Comput Biol Med. 2001 Mar;31(2):133-42
references.pmid: 11165220
references.citation: J Magn Reson Imaging. 1996 Sep-Oct;6(5):753-63
references.pmid: 8890013
references.citation: Semin Nucl Med. 2002 Jan;32(1):2-5
references.pmid: 11839067
references.citation: J Nucl Med. 1991 Apr;32(4):623-48; discussion 649-50
references.pmid: 2013803
references.citation: J Nucl Med. 2003 Dec;44(12 ):1933-9
references.pmid: 14660719
references.citation: J Nucl Med. 2001 May;42(5 Suppl):1S-93S
references.pmid: 11483694
references.citation: IEEE Trans Med Imaging. 1995;14(3):480-6
references.pmid: 18215852
references.citation: J Comput Assist Tomogr. 1992 Sep-Oct;16(5):784-8
references.pmid: 1522274
references.citation: Exp Hematol. 2001 May;29(5):563-71
references.pmid: 11376868
references.citation: Comput Med Imaging Graph. 2003;27(1):43-51
references.pmid: 12573889
references.citation: Nucl Med Commun. 2004 Jul;25(7):651-6
references.pmid: 15208491
references.citation: J Nucl Med. 1995 Oct;36(10 ):1836-9
references.pmid: 7562051
references.citation: Eur J Nucl Med. 2001 Sep;28(9):1326-35
references.pmid: 11585291
references.citation: Eur J Cancer. 2000 May;36(7):858-67
references.pmid: 10785590
references.citation: Eur J Nucl Med. 1996 Oct;23 (10 ):1409-15
references.pmid: 8781149
references.citation: Comp Biochem Physiol A Mol Integr Physiol. 2000 Jan;125(1):75-83
references.pmid: 10779733
references.citation: J Cereb Blood Flow Metab. 1996 Jan;16(1):60-8
references.pmid: 8530556
references.citation: Mol Imaging Biol. 2002 May;4(3):219-31
references.pmid: 14537126
references.citation: J Nucl Med. 1997 Oct;38(10 ):1614-23
references.pmid: 9379202
references.citation: Magn Reson Med. 1993 Aug;30(2):161-73
references.pmid: 8366797
references.citation: Eur J Cancer. 2003 Jul;39(11):1525-34
references.pmid: 12855258
references.citation: Int J Rad Appl Instrum B. 1990;17(3):273-9
references.pmid: 2341282