title: Serotonin 2A receptor gene polymorphism and personality traits: no evidence for significant association.
abstract: A number of studies have observed associations between the serotonin 2A (5-HT2A) receptor and mental disorders. Here, we investigated correlations between polymorphisms (-1438G/A and 102T/C) of the 5-HT2A gene and personality traits in healthy Japanese volunteers (n = 239). The personality traits were evaluated using the Revised NEO Personality Inventory (NEO PI-R). The -1438G/A and 102T/C were in complete linkage disequilibrium. There was a tendency for associations between the genotype and the scores for Agreeableness, Conscientiousness and Neuroticism of the NEO PI-R (P = 0.028, 0.039 and 0.062, respectively; analysis of variance, uncorrected for multiple testing). Subjects with the A/A of -1438G/A (or T/T of 102T/C) appeared to be lower in Neuroticism and higher in Conscientiousness than the rest of the subjects. However, the results were statistically non-significant after Bonferroni's correction for multiple testing of the five scales of the NEO PI-R. Thus, the present study provided no evidence for statistically significant associations between the 5-HT2A polymorphisms and the personality traits.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Umekage
authors.forename: Chieko
authors.initials: C
authors.lastname: Kato
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Marui
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otowa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hibino
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Otani
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Kohda
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D001007:Anxiety / Q000235:genetics; D005260:Female; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008297:Male; D009497:Neurotic Disorders / Q000235:genetics; D010551:Personality / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A