Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study.
A role for matrix proteins has previously been proposed in the pathogenesis of arterial calcification in the setting of atherosclerosis, and a link has been suggested between osteoporosis and arterial calcification. Our aim has been to investigate whether matrix Gla protein (MGP) T-138C, osteopontin (SPP1) T-443C, and Asp94Asp single nucleotide polymorphisms are associated with the development of arterial calcification and bone density. The individual effects of the MGP and SPP1 polymorphisms with coronary calcification are weak and not statistically significant. Bone mineral density differences at both the hip and spine do not vary statistically by genotype for any of the polymorphisms studied. Given the significant role of both MGP and SPP1 in arteriosclerosis, further research in higher risk, older populations are needed to determine fully the way in which MGP and SPP1 polymorphisms are associated with disease.
Taylor
Brent C
BC
Center for Chronic Disease Outcomes Research, VA Medical Center (152/2E), One Veterans Drive, Minneapolis, MN 55417, USA. taylorbc@umn.edu
Schreiner
Pamela J
PJ
Doherty
Terence M
TM
Fornage
Myriam
M
Carr
J Jeffrey
JJ
Sidney
Steve
S
D044383:Black People / Q000235:genetics; D015519:Bone Density; D002114:Calcinosis / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D006615:Hip / Q000473:pathology; D006801:Humans; D008297:Male; D053495:Osteopontin; D020641:Polymorphism, Single Nucleotide; D012795:Sialoglycoproteins / Q000235:genetics*; D013131:Spine / Q000473:pathology; D044465:White People / Q000235:genetics; D000097568:Matrix Gla Protein
D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D053495:Osteopontin; D012795:Sialoglycoproteins; D000097568:Matrix Gla Protein; C506895:SPP1 protein, human
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