title: Serum levels of advanced glycation end products are associated with in-stent restenosis in diabetic patients.
abstract: The formation of advanced glycation end products (AGEs), in various tissues has been known to enhance immunoinflammatory reactions and local oxidant stresses in long standing diabetes. Recently, AGEs have been reported to play a role in neointimal formation in animal models of arterial injury. We attempted to determine whether the serum levels of AGEs are associated with coronary restenosis in diabetic patients. Blood samples were collected from diabetic patients with coronary artery disease undergoing stent implantation and the serum levels of AGEs were analyzed by the fluorescent intensity method. The development of in-stent restenosis (ISR) was evaluated by a 6-month follow-up coronary angiography. A total of 263 target lesions were evaluated, in 203 patients. The ISR rate in the high-AGE (>170 U/ml) group (40.1%) was significantly higher than in the low-AGE group (<or=170 U/ml) (19.6%) (p<0.001). Furthermore, multivariate analysis revealed that a high level of serum AGEs is an independent risk factor for the development of ISR (odds ratio, 2.659; 95% CI, 1.431-4.940; p=0.002). The serum levels of AGEs constitute an excellent predictive factor for ISR, and should be one of the guidelines for medical therapy and interventional strategy to prevent ISR in diabetic patients.
authors.affiliation: Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Eui-Young
authors.initials: EY
authors.lastname: Choi
authors.forename: Hyuck Moon
authors.initials: HM
authors.lastname: Kwon
authors.forename: Chul-Woo
authors.initials: CW
authors.lastname: Ahn
authors.forename: Geun Taek
authors.initials: GT
authors.lastname: Lee
authors.forename: Boyoung
authors.initials: B
authors.lastname: Joung
authors.forename: Bum Kee
authors.initials: BK
authors.lastname: Hong
authors.forename: Young Won
authors.initials: YW
authors.lastname: Yoon
authors.forename: Dongsoo
authors.initials: D
authors.lastname: Kim
authors.forename: Ki-Hyun
authors.initials: KH
authors.lastname: Byun
authors.forename: Tae Soo
authors.initials: TS
authors.lastname: Kang
authors.forename: Se-Jung
authors.initials: SJ
authors.lastname: Yoon
authors.forename: Sung Woo
authors.initials: SW
authors.lastname: Kwon
authors.forename: Sung-Ju
authors.initials: SJ
authors.lastname: Lee
authors.forename: Jong-Kwan
authors.initials: JK
authors.lastname: Park
authors.forename: Hyun-Seung
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000378:metabolism* / Q000628:therapy*; D023903:Coronary Restenosis / Q000453:epidemiology / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015607:Stents
chemical_list: D017127:Glycation End Products, Advanced
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