Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein.
The adducin family of proteins interacts with the actin cytoskeleton and the plasma membrane in a calcium- and cAMP-dependent manner. Thus, adducins may be involved in changes in cytoskeletal organization resulting from synaptic stimulation. beta-Adducin knock-out mice were examined in physiological and behavioral paradigms related to synaptic plasticity to elucidate the role the adducin family plays in processes underlying learning and memory. In situ hybridization for alpha- and beta-adducin demonstrates that these mRNAs are found throughout the brain, with high levels of expression in the hippocampus. Schaffer collateral-CA1 tetanic long-term potentiation decayed rapidly in acute hippocampal slices from beta-adducin knock-out mice, although baseline spine morphology and postsynaptic density were normal. Interestingly, the input-output relationship was significantly increased in hippocampal slices from beta-adducin knock-out mice. Furthermore, beta-adducin knock-out mice were impaired in performance of fear conditioning and the water maze paradigm. The current results indicate that beta-adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory.
Rabenstein
Rebecca L
RL
Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut 06508, USA.
Addy
Nii A
NA
Caldarone
Barbara J
BJ
Asaka
Yukiko
Y
Gruenbaum
Lore M
LM
Peters
Luanne L
LL
Gilligan
Diana M
DM
Fitzsimonds
Reiko M
RM
Picciotto
Marina R
MR
D000199:Actins / Q000378:metabolism*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D002148:Calmodulin-Binding Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism* / Q000648:ultrastructure; D003712:Dendrites / Q000648:ultrastructure; D004597:Electroshock; D005239:Fear / Q000502:physiology; D005260:Female; D046352:Freezing Reaction, Cataleptic / Q000502:physiology; D006179:Gyrus Cinguli / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D007859:Learning Disabilities / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000235:genetics* / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008818:Mice, Neurologic Mutants; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D009473:Neuronal Plasticity / Q000235:genetics / Q000502:physiology*; D009714:Nucleus Accumbens / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D000099291:Adducins
D000199:Actins; D002148:Calmodulin-Binding Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D000099291:Adducins
Cell. 2001 Nov 30;107(5):605-16
11733060
Annu Rev Physiol. 2002;64:355-405
11826273
Blood. 2002 Apr 1;99(7):2418-26
11895774
Behav Brain Res. 2002 Aug 21;134(1-2):113-21
12191797
Science. 2002 Oct 25;298(5594):776-80
12399578
Sci STKE. 2002 Oct 29;2002(156):re14
12407224
Hippocampus. 2002;12(5):609-36
12440577
Physiol Behav. 2002 Dec;77(4-5):489-93
12526988
Synapse. 2003 Jun 1;48(3):149-53
12645040
J Neurosci. 2003 Apr 1;23(7):2675-85
12684453
Cell Mol Neurobiol. 2003 Oct;23(4-5):727-38
14514027
Brain Res. 2003 Nov 14;990(1-2):28-37
14568326
Ann N Y Acad Sci. 2003 Nov;1003:1-11
14684431
Physiol Rev. 2004 Jan;84(1):87-136
14715912
Neurosci Biobehav Rev. 2004 Jan;27(8):765-76
15019426
Neuroreport. 2004 Apr 9;15(5):829-32
15073524
Curr Opin Neurobiol. 2004 Apr;14(2):139-47
15082317
Curr Opin Neurobiol. 2004 Apr;14(2):148-55
15082318
Nat Neurosci. 2004 Oct;7(10):1104-12
15361876
Neuron. 2004 Oct 14;44(2):321-34
15473970
Nature. 1987 Jul 23-29;328(6128):359-62
3600811
Neurosci Lett. 1987 Jun 15;77(2):187-92
3601229
J Cell Biol. 1987 Dec;105(6 Pt 1):2837-45
3693401
Annu Rev Neurosci. 1989;12:13-31
2648947
Nature. 1994 Jun 9;369(6480):493-7
7911226
Biochem Biophys Res Commun. 1994 Nov 30;205(1):460-6
7999065
J Biol Chem. 1995 Aug 11;270(32):18990-6
7642559
J Biol Chem. 1995 Oct 27;270(43):25534-40
7592723
Brain Res. 1995 Nov 27;700(1-2):13-24
8624703
J Biol Chem. 1996 Apr 5;271(14):7986-91
8626479
J Biol Chem. 1996 Oct 11;271(41):25157-66
8810272
Behav Brain Res. 1996 Jan;74(1-2):217-27
8851933
Biochem Biophys Res Commun. 1997 Aug 28;237(3):685-9
9299427
J Neurosci. 1998 Jan 1;18(1):93-103
9412489
J Gen Physiol. 1998 Feb;111(2):243-55
9450942
J Neurosci. 1998 Apr 1;18(7):2423-36
9502803
J Cell Biol. 1998 Jul 27;142(2):485-97
9679146
Science. 1999 Mar 19;283(5409):1923-7
10082466
J Cell Biol. 1999 Apr 19;145(2):347-61
10209029
Nature. 1999 May 6;399(6731):66-70
10331391
J Neurosci. 1999 Jun 1;19(11):4314-24
10341235
Science. 1999 Jun 11;284(5421):1811-6
10364548
Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10717-22
10485892
Mamm Genome. 2000 Jan;11(1):16-23
10602987
Eur J Neurosci. 2000 Feb;12(2):563-70
10712635
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6856-61
10823894
Biochimie. 2000 Apr;82(4):353-63
10865123
Neuropharmacology. 2000 Oct;39(13):2779-84
11044747
J Cell Sci. 2001 Mar;114(Pt 6):1041-52
11228149
Annu Rev Neurosci. 2001;24:1071-89
11520928
Neuron. 2001 Sep 13;31(5):681-97
11567610