title: Ferret odor as a processive stress model in rats: neurochemical, behavioral, and endocrine evidence.
abstract: Predator odors have been shown to elicit stress responses in rats. The present studies assessed the use of domestic ferret odor as a processive stress model. Plasma corticosterone and adrenocorticotropin hormone levels were higher after 30 min of exposure to ferret odor (fur/skin) but not control odors, ferret feces, urine, or anal gland secretions. Behavioral differences were also found between ferret and the control odors as tested in a defensive withdrawal paradigm. In addition, c-fos messenger RNA expression in several brain areas previously associated with processive stress was significantly higher in ferret odor-exposed rat brains than in control odor-exposed brains. These results suggest that ferret odor produces a reliable unconditioned stress response and may be useful as a processive stress model.
authors.affiliation: Department of Psychology, University of Colorado, Boulder, CO 80309-0345, USA. masinic@psych.colorado.edu
authors.forename: C V
authors.initials: CV
authors.lastname: Masini
authors.forename: S
authors.initials: S
authors.lastname: Sauer
authors.forename: S
authors.initials: S
authors.lastname: Campeau
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001921:Brain / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D005289:Ferrets; D008297:Male; D009812:Odorants; D011235:Predatory Behavior; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000503:physiopathology*
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
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