title: Secondary generalized dystonia without basal ganglia damage.
abstract: We report the case of a woman who developed generalized dystonia, severe cognitive deficits and dysphagia following an overdose of the hypoglycaemic drug, sulphonylurea. The MRI reveals frontal and temporal lobe atrophy, but no evidence of damage to the basal ganglia. This case adds to the small number of previously reported cases with secondary dystonia seemingly due to cortical rather than subcortical damage.
authors.affiliation: Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Mahapatra
authors.forename: Pablo
authors.initials: P
authors.lastname: Mir
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Edwards
authors.forename: David
authors.initials: D
authors.lastname: Allen
authors.forename: Kailash P
authors.initials: KP
authors.lastname: Bhatia
mesh_terms: D000328:Adult; D001479:Basal Ganglia; D003680:Deglutition Disorders / Q000139:chemically induced / Q000473:pathology; D004421:Dystonia / Q000139:chemically induced* / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000506:poisoning*; D008279:Magnetic Resonance Imaging; D013406:Suicide, Attempted; D013453:Sulfonylurea Compounds / Q000506:poisoning*; D013702:Temporal Lobe / Q000473:pathology
chemical_list: D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds