title: Acquired reactive perforating collagenosis in a patient with lung fibrosis.
abstract: Reactive perforating collagenosis (RPC) is a rare disorder characterized by the transepidermal elimination of altered collagen. The inherited form of RPC begins in early childhood, but acquired reactive perforating collagenosis (ARPC) begins in adult life. ARPC is associated with diabetes mellitus, renal disease, and malignancy. ARPC with lung fibrosis has not previously been reported in the literature, and the relationship between ARPC and lung fibrosis has not been studied. The etiological relationship between the two disorders appears to be uncertain. Although their association in this case could be due to chance, it may be due to the transforming growth factor beta abnormalities seen in both diseases. In this report, we describe a case of ARPC with lung fibrosis and propose an etiological association between the two diseases.
authors.affiliation: Department of Dermatology, Kitasato University School of Medicine, Kanagawa, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Tsuboi
authors.forename: Akira
authors.initials: A
authors.lastname: Mukuno
authors.forename: Naoya
authors.initials: N
authors.lastname: Sato
authors.forename: Kensei
authors.initials: K
authors.lastname: Katsuoka
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yanase
mesh_terms: D003094:Collagen / Q000032:analysis / Q000648:ultrastructure; D003095:Collagen Diseases / Q000150:complications* / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000150:complications*; D017444:Skin Diseases, Papulosquamous / Q000150:complications* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000032:analysis; D053773:Transforming Growth Factor beta1
chemical_list: C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D003094:Collagen