[Molecular mechanism of tissue-specific infection of poliovirus].
Poliovirus is the causative agent of an acute disease of the central nervous system, poliomyelitis. Poliovirus will be eradicated in the near future by a world-wide vaccination program. Poliovirus is a neurotropic virus that produces severe lesions selectively in the CNS. However, a basic question why poliovirus exhibits neurotropic property has not been elucidated. Poliovirus receptor and host factors involved in the translation initiation of viral protein, which are required for virus replication, play important roles in determining tissue tropism. We found that type I interferon response is also an important determinant of poliovirus tissue tropism. Type I interferon inhibits viral replication in the non-target tissues. The tissue tropism of poliovirus may be determined based on the balance of these mechanisms.
Koike
Satoshi
S
Department of Microbiology and Immunology, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2-6 Musashidai, Fuchu, Tokyo. koike@tmin.ac.jp
D020121:5' Untranslated Regions; D000818:Animals; D002490:Central Nervous System / Q000821:virology*; D006801:Humans; D007370:Interferon Type I / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D009928:Organ Specificity / Q000235:genetics*; D011051:Poliomyelitis / Q000821:virology*; D017955:Poliovirus / Q000502:physiology*; D014176:Protein Biosynthesis; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000502:physiology; D011991:Receptors, Virus / Q000502:physiology*; D018523:Tropism / Q000235:genetics; D014779:Virus Replication / Q000235:genetics
D020121:5' Untranslated Regions; D007370:Interferon Type I; D008565:Membrane Proteins; D017471:Receptors, Interferon; D011991:Receptors, Virus; C066100:poliovirus receptor; D053633:Receptor, Interferon alpha-beta