title: Microelectrochemical approach to induce local cell adhesion and growth on substrates.
abstract: The nature of an albumin-coated substrate that blocks protein adsorption and cell adhesion was rapidly switched to cell-adhesive by exposure to an oxidizing agent such as HBrO. This finding has enabled cellular pattern drawing even on a single-cell level by closely scanning a microelectrode above the substrate and electrochemically producing the agent at the tip of the electrode. The present microelectrochemical cell patterning is applicable even for a previously cell-patterned substrate and for a grooved substrate. These unique technical features will have impacts on a variety of cell-based studies that require the analysis of heterotypic cell-cell interactions and cellular arrangement on an uneven surface such as semiconductor devices.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kaji
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Kanada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Oyamatsu
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Matsue
authors.forename: Matsuhiko
authors.initials: M
authors.lastname: Nishizawa
mesh_terms: D001959:Bromates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects*; D004563:Electrochemistry; D006367:HeLa Cells; D006801:Humans; D008839:Microelectrodes; D012666:Semiconductors; D012710:Serum Albumin, Bovine / Q000737:chemistry* / Q000187:drug effects*; D013499:Surface Properties
chemical_list: D001959:Bromates; D012710:Serum Albumin, Bovine; C027664:hypobromous acid