title: Histopathological findings of epithelial ingrowth after laser in situ keratomileusis.
abstract: OBJECTIVE
  To investigate the histopathological features of epithelial ingrowth after laser in situ keratomileusis (LASIK).
  
  
  METHODS
  Five epithelial ingrowth specimens of 4 patients (2 to 17 months after initial LASIK) were examined. The lesions were surgically removed and examined using light and transmission electron microscopy.
  
  
  RESULTS
  Early epithelial ingrowth was clinically observed as faint opacities with demarcation lines and epithelial pearls. Late epithelial ingrowth was observed as homogeneous whitish masses. Histopathologically, early epithelial ingrowth consisted of multilayered squamous epithelium resembling normal corneal epithelium, whereas late ingrowth was made up of clumps containing amorphous materials with scarce cellular elements.
  
  
  CONCLUSIONS
  Our findings suggest that clinical appearance and histopathology of epithelial ingrowth from LASIK flap margins differ in early and late stages, which might reflect proliferative activity of the lesions.
authors.affiliation: Minamiaoyama Eye Clinic, Tokyo, Japan. naokato@bc.iij4u.or.jp
authors.forename: Naoko
authors.initials: N
authors.lastname: Asano-Kato
authors.forename: Ikuko
authors.initials: I
authors.lastname: Toda
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Hori-Komai
authors.forename: Yoji
authors.initials: Y
authors.lastname: Takano
authors.forename: Murat
authors.initials: M
authors.lastname: Dogru
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000601:surgery; D003318:Corneal Opacity / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D019573:Epithelium, Corneal / Q000601:surgery / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery; D011183:Postoperative Complications; D013524:Surgical Flaps / Q000473:pathology*