Mutational analysis of metronidazole resistance in Helicobacter pylori.
Metronidazole is one of a few antibiotics effective in eliminating Helicobacter pylori infection of the human stomach. Several chromosomal loci have been implicated in resistance to this drug. Saturation transposon mutagenesis of the H. pylori genome revealed inactivation of the rdxA gene as uniquely able to confer metronidazole resistance.
Moore
Jill M
JM
Human Biology Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle WA 98109-1024, USA.
Salama
Nina R
NR
D001426:Bacterial Proteins / Q000235:genetics*; D024881:Drug Resistance, Bacterial; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics; D008795:Metronidazole / Q000494:pharmacology*; D009154:Mutation; D009601:Nitroreductases / Q000235:genetics*
D001426:Bacterial Proteins; D008795:Metronidazole; D009601:Nitroreductases; C476646:RdxA protein, Helicobacter pylori
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