Bioactive constituents from Boswellia papyrifera.
Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxystilbene-5-O-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (2), and a new triterpene, 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oic acid (3), along with five known compounds, 11-keto-beta-boswellic acid (4), beta-elemonic acid (7), 3alpha-acetoxy-11-keto-beta-boswellic acid (8), beta-boswellic acid (9), and beta-sitosterol (10). The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities.
Atta-ur-Rahman
H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
Naz
Humera
H
Fadimatou
Makhmoor
Talat
T
Yasin
Amsha
A
Fatima
Naheed
N
Ngounou
F N
FN
Kimbu
S F
SF
Sondengam
B L
BL
Choudhary
M Iqbal
MI
D029743:Boswellia / Q000737:chemistry*; D002163:Cameroon; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D004791:Enzyme Inhibitors; D006027:Glycosides; D013267:Stilbenes; D014315:Triterpenes; C498484:trans-4',5-dihydroxy-3-methoxystilbene-5-O-(alpha-L-rhamnopyranosyl-(1-2)-alpha-L-rhamnopyranosyl-(1-6))-beta-D-glucopyranoside; C498485:trans-4',5-dihydroxy-3-methoxystilbene-5-O-(alpha-L-rhamnopyranosyl-(1-6))-beta-D-glucopyranoside