title: Protection of urinary bladder function by grape suspension.
abstract: Urinary bladder dysfunction secondary to BPH is a major affliction of aging men. A rabbit model of partial outlet obstruction was used to evaluate the ability of a standardized grape suspension to protect the bladder against obstructive bladder dysfunction.Twenty-four New Zealand White rabbits were separated into four groups of six rabbits each. Groups 1 and 3 were pretreated by oral gavage for 3 weeks with a standardized grape suspension suspended in water; groups 2 and 4 were treated with vehicle. Groups 1 and 3 received sham operations after 3 weeks of treatment; groups 2 and 4 received partial outlet obstruction by surgically placing a silk ligature loosely around the urethra. At 3 weeks following surgery, in vivo and in vitro bladder functions were evaluated. Based on both in vivo and in vitro studies, the grape suspension significantly reduced the severity of obstructed bladder dysfunction. This is consistent with the hypothesis that ischemia is a major etiological factor in obstructive dysfunction, and treatment with antioxidants and membrane stabilization compounds such as those in the grape suspension can be effective in the treatment of obstructive bladder pathology.
authors.affiliation: Abant Izzet Baysal University Medicine School of Duzce, Turkey.
authors.forename: Canan Aldirmaz
authors.initials: CA
authors.lastname: Agartan
authors.forename: Catherine
authors.initials: C
authors.lastname: Whitbeck
authors.forename: Rebekah
authors.initials: R
authors.lastname: Sokol
authors.forename: Paul
authors.initials: P
authors.lastname: Chichester
authors.forename: Robert M
authors.initials: RM
authors.lastname: Levin
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D007537:Isometric Contraction / Q000187:drug effects / Q000502:physiology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011470:Prostatic Hyperplasia / Q000517:prevention & control*; D011817:Rabbits; D001743:Urinary Bladder / Q000187:drug effects / Q000502:physiology; D001748:Urinary Bladder Neck Obstruction / Q000517:prevention & control*; D014563:Urodynamics / Q000187:drug effects*; D027843:Vitis
chemical_list: D000317:Adrenergic alpha-Antagonists; D010936:Plant Extracts