Selenocarbamates are effective superoxide anion scavengers in vitro.
We investigated the superoxide anion-scavenging effects of six selenocarbamates and four thiocarbamates, using a highly sensitive quantitative chemiluminescence method. At 333 nM, six selenocarbamates and four thiocarbamates scavenged in the range of 2.9-68.7% of O(2)*-. Se-methyl N-phenylselenocarbamate and Se-methyl N-(4-methylphenyl)selenocarbamate exhibited the strongest superoxide anion-scavenging activity among the Se-selenocarbamates. In contrast, the corresponding S-thiocarbamates had moderate inhibitory effect. The 50% inhibitory concentrations (IC(50)) of Se-methyl-N-phenylselenocarbamate and Se-methyl-N-(4-methylphenyl)selenocarbamate were determined to be 140 nM and 162 nM, respectively. Thus, these compounds acted in vitro as effective and potentially useful O(2)*- scavengers.
Takahashi
Hitoe
H
Gunma Industrial Technology Center, 884-1 Kamesato, Maebashi, Gunma 379-2147, Japan.
Nishina
Atsuyoshi
A
Fukumoto
Ryo-hei
RH
Kimura
Hirokazu
H
Koketsu
Mamoru
M
Ishihara
Hideharu
H
D002219:Carbamates / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000378:metabolism* / Q000494:pharmacology; D018036:Selenium Compounds / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism*; D013859:Thiocarbamates / Q000494:pharmacology
D002219:Carbamates; D016166:Free Radical Scavengers; D018036:Selenium Compounds; D013859:Thiocarbamates; D013481:Superoxides