Lambda interferon inhibits hepatitis B and C virus replication.
Lambda interferon (IFN-lambda) induces an intracellular IFN-alpha/beta-like antiviral response through a receptor complex distinct from the IFN-alpha/beta receptor. We therefore determined the ability of IFN-lambda to inhibit hepatitis B virus (HBV) and hepatitis C virus (HCV) replication. IFN-lambda inhibits HBV replication in a differentiated murine hepatocyte cell line with kinetics and efficiency similar to IFN-alpha/beta and does not require the expression of IFN-alpha/beta or IFN-gamma. Furthermore, IFN-lambda blocked the replication of a subgenomic and a full-length genomic HCV replicon in human hepatocyte Huh7 cells. These results suggest the possibility that IFN-lambda may be therapeutically useful in the treatment of chronic HBV or HCV infection.
Robek
Michael D
MD
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA. michael.robek@yale.edu
Boyd
Bryan S
BS
Chisari
Francis V
FV
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002478:Cells, Cultured; D016174:Hepacivirus / Q000187:drug effects / Q000502:physiology*; D006515:Hepatitis B virus / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D007372:Interferons
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