Junctional epidermolysis bullosa in two domestic shorthair kittens.
This article describes two cases of junctional epidermolysis bullosa in nonrelated kittens. Both cats exhibited pinnal erosions, oral ulcerations and severe onychomadesis. Histopathology, electron microscopy and/or indirect immunoperoxidase revealed subepidermal clefting, with the lamina densa remaining attached to the floor of the vesicles. Indirect immunofluorescence revealed reduced staining for laminin-5 gamma2 subunit in case 1 and beta3 subunit in case 2.
Alhaidari
Zeineb
Z
Clinique Vétérinaire, Cidex 248, RN 85, 06330 Roquefort les Pins, France. z.alhaidari@wanadoo.ft
Olivry
Thierry
T
Spadafora
Anne
A
Thomas
Randall C
RC
Perrin
Christophe
C
Meneguzzi
Guerrino
G
Ortonne
Jean Paul
JP
D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D016109:Epidermolysis Bullosa, Junctional / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007797:Laminin / Q000096:biosynthesis; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary
D007797:Laminin