title: Vasopressin: physiology and clinical use in patients with vasodilatory shock: a review.
abstract: Vasopressin is a nonapeptide synthesised in the hypothalamus and released upon stimulations such as hyperosmolality, hypotension and hypovolaemia. In acute shock states serum vasopressin levels increase rapidly and decrease in prolonged septic shock. The administration of vasopressin in healthy subjects has little effect, whereas in vasodilatory shock it increases the mean arterial pressure through V1 receptors and decreases the cardiac output. Vasopressin stimulates the V2 receptors in the kidney leading to reabsorption of water through aquaporin 2. However, in vasodilatory shock the antidiuretic effects are overcome by the effect vasopressin has on the kidneys: improvement of renal blood flow leading to water excretion. Twenty-four studies on the use of vasopressin in patients with vasodilatory shock are reviewed. They show that vasopressin potentiates norepinephrine effects, increases blood pressure significantly in patients with vasodilatory shock and may improve renal function. Side effects ranging from ischaemic skin lesions to possible intestinal ischaemia should not be underestimated. Above a dose of 0.04 U/min it may lead to cardiac arrest. Effects on mortality cannot be interpreted from these studies. Broad clinical use should await controlled trials to clarify its effects on clinical outcomes such as organ failure and mortality.
authors.affiliation: Department of General Internal Medicine, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands. D.T.den_Ouden@lumc.nl
authors.forename: D T
authors.initials: DT
authors.lastname: den Ouden
authors.forename: A E
authors.initials: AE
authors.lastname: Meinders
mesh_terms: D000818:Animals; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D012769:Shock / Q000188:drug therapy*; D012772:Shock, Septic / Q000188:drug therapy*; D014664:Vasodilation / Q000187:drug effects; D014667:Vasopressins / Q000502:physiology / Q000627:therapeutic use; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D014667:Vasopressins; D009638:Norepinephrine