title: Ex vivo measures of LDL oxidative susceptibility predict carotid artery disease.
abstract: OBJECTIVE
  The purpose of the study was to assess whether ex vivo measures of low-density lipoprotein (LDL) oxidation improved prediction of carotid artery disease (CAAD) case-control status compared to standard lipid and smoking measures.
  
  
  METHODS
  One hundred and forty cases with a high degree of carotid artery stenosis aged 40-83 years and an equal number of controls without stenosis or other vascular disease were matched by censored age within 2 years. Matched logistic regression evaluated the significance of copper-induced oxidative measures with and without covariates. The relationship of LDL oxidation measures with statin use and current smoking was also evaluated.
  
  
  RESULTS
  Logistic regression demonstrated a significant effect of the three correlated measures of oxidative susceptibility (lag time, oxidation rate and maximal rate of oxidation) separately on disease prediction (all p<0.05). These oxidative measures remained significant predictors of case-control status when other cardiovascular disease predictors (age; LDL-C, HDL-C and ApoAI levels; current smoking, ever smoking and pack-years smoked) were jointly considered. This relationship was not attributable to the effects of statin use on LDL oxidation.
  
  
  CONCLUSIONS
  Ex vivo measures of oxidation improved the prediction of carotid artery disease status, suggesting that this is an important determinant of atherosclerotic risk in this older population.
authors.affiliation: Division of Medical Genetics, The University of Washington Department of Medicine, Seattle, WA 98195, USA.
authors.forename: Audrey
authors.initials: A
authors.lastname: Hendrickson
authors.forename: Laura A
authors.initials: LA
authors.lastname: McKinstry
authors.forename: Julieann K
authors.initials: JK
authors.lastname: Lewis
authors.forename: Jeremy
authors.initials: J
authors.lastname: Lum
authors.forename: Andy
authors.initials: A
authors.lastname: Louie
authors.forename: Gerard D
authors.initials: GD
authors.lastname: Schellenberg
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Hatsukami
authors.forename: Alan
authors.initials: A
authors.lastname: Chait
authors.forename: Gail P
authors.initials: GP
authors.lastname: Jarvik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002340:Carotid Artery Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism*; D016893:Carotid Stenosis / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000378:metabolism*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011237:Predictive Value of Tests; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology
chemical_list: D008078:Cholesterol, LDL