mecA is not involved in the sigmaB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis.
A lack of sigma(B) activity reduces methicillin resistance in heterogeneous Staphylococcus epidermidis 1057, whereas inactivation of the anti-sigma factor RsbW switched the phenotype to homogeneous expression of resistance. Oxacillin induction of mecA transcription is reduced in a sigma(B)-negative strain. However, mecA is not involved in the switch of expression phenotype.
Knobloch
Johannes K-M
JK
Universitätsklinikum Hamburg-Eppendorf, Zentrum für Klinisch-Theoretische Medizin, Institut für Infektionsmedizin, Martinistr. 52, D-20246 Hamburg, Germany. knobloch@uke.uni-hamburg.de
Jäger
Sebastian
S
Huck
Jörn
J
Horstkotte
Matthias A
MA
Mack
Dietrich
D
D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D016106:Methicillin Resistance; D010068:Oxacillin / Q000494:pharmacology; D010641:Phenotype; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012808:Sigma Factor / Q000502:physiology*; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000235:genetics; D014158:Transcription, Genetic
D001426:Bacterial Proteins; C487495:MecA protein, Staphylococcus epidermidis; C079011:SigB protein, Bacteria; D012808:Sigma Factor; D010068:Oxacillin
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