Hürthle (oncocytic) cell tumors of thyroid: etiopathogenesis, diagnosis and clinical significance.
The etiopathogenesis and the classification of oncocytic (Hürthle cell) tumors of the thyroid is reviewed with an emphasis on the role played by mitochondrial and nuclear genetic abnormalities that interfere with mitochondrial function. Oxyphilia is classified into primary or secondary and the so-called Hürthle cell carcinoma is divided into oncocytic (Hürthle cell) variants of papillary and follicular carcinoma.
Sobrinho-Simões
Manuel
M
Department of Pathology, Medical Faculty of the University of Porto, Portugal.
Máximo
Valdemar
V
Castro
Inês Vieira de
IV
Fonseca
Elsa
E
Soares
Paula
P
Garcia-Rostan
Ginesa
G
Oliveira
Manuel Cardoso de
MC
D018249:Adenoma, Oxyphilic / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D002467:Cell Nucleus / Q000235:genetics / Q000473:pathology; D004272:DNA, Mitochondrial; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000473:pathology; D013964:Thyroid Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology*
D004272:DNA, Mitochondrial