Potential clindamycin resistance in clindamycin-susceptible, erythromycin-resistant Staphylococcus aureus: report of a clinical failure.
The erm gene product confers clindamycin resistance on Staphylococcus aureus. We report a clindamycin clinical failure where resistance developed on therapy in a D-test-positive strain. D tests of 91 clindamycin-susceptible, erythromycin-resistant S. aureus isolates showed that 68% of methicillin-susceptible and 12.3% of methicillin-resistant S. aureus strains were D-test positive.
Levin
Todd P
TP
Temple University Hospital, Section of Infectious Diseases, 3401 North Broad St., Philadelphia, PA 19140, USA. TLevin9696@yahoo.com
Suh
Byungse
B
Axelrod
Peter
P
Truant
Allan L
AL
Fekete
Thomas
T
D000328:Adult; D002981:Clindamycin / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects*
D002981:Clindamycin; D004917:Erythromycin
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