title: Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer.
abstract: To identify genes that generally increase the risk of cancer, we performed a systematic search throughout the genome in 188 families primarily ascertained for prostate cancer but which also included individuals with other cancers. We observed significant evidence for linkage between susceptibility to all cancers and markers at 3p24, with a peak HLOD of 3.08 (P=0.0002). Compared to families with less than three other cancers and prostate cancer only, evidence for linkage at this region was stronger among families with at least three other cancers. This is the first reported example of a genome-wide search for general cancer susceptibility genes among hereditary prostate cancer families.
authors.affiliation: Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
authors.forename: Bao-Li
authors.initials: BL
authors.lastname: Chang
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Gillanders
authors.forename: Sarah D
authors.initials: SD
authors.lastname: Isaacs
authors.forename: Kathy E
authors.initials: KE
authors.lastname: Wiley
authors.forename: Tamara
authors.initials: T
authors.lastname: Adams
authors.forename: Aubrey R
authors.initials: AR
authors.lastname: Turner
authors.forename: S Lilly
authors.initials: SL
authors.lastname: Zheng
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Meyers
authors.forename: John D
authors.initials: JD
authors.lastname: Carpten
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Walsh
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Trent
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.forename: William B
authors.initials: WB
authors.lastname: Isaacs
mesh_terms: D002893:Chromosomes, Human, Pair 3; D005190:Family; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010375:Pedigree; D011471:Prostatic Neoplasms / Q000235:genetics*