title: Clinical characteristics of elderly patients with a cautious gait of unknown origin.
abstract: OBJECTIVE
  To evaluate and systematically characterize a group of older adults with disturbed gait of unknown origin.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Outpatient clinic in a movement disorders unit.
  
  
  METHODS
  Twenty-five patients (mean age 78.4 years) with a disturbed gait of unknown origin were compared with twenty-eight age matched "healthy" controls (mean age 78.2).
  
  
  METHODS
  Detailed medical history, geriatric and neurological assessments.
  
  
  RESULTS
  Patients walked more slowly (P<0.0001) and with shorter strides (P<0.0001) compared with controls. Muscle strength was lower, and static and dynamic balance and gait performance were worse among the patients (P<0.0001). The patients also tended to be more depressed (P<0.0001),more anxious (P<0.002), had a greater fear of falling (P<0.0001) and had lower scores on the Mini-Mental State Examination (P<0.005). There was no difference in the frequency of cerebellar or pyramidal signs in the two groups. However, neurological testing revealed that extrapyramidal (P<0.0001) and frontal release signs (P<0.0001) were more common among the patients. Neuroradiological findings were rare among the patients and they did not explain the changes in gait speed or fear of falling.
  
  
  CONCLUSIONS
  Older adults with a disturbed gait of unknown origin appear to share common characteristics. They walk more slowly than "healthy" controls with increased unsteadiness and with excessive fear of falling. The extrapyramidal, frontal lobe, and limbic systems apparently play an important role, to different degrees, in what can be viewed as a multisystem neurodegenerative syndrome clearly different from "aging."
authors.affiliation: Dept. of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. ngiladi@tasmc.health.gov.il
authors.forename: N
authors.initials: N
authors.lastname: Giladi
authors.forename: T
authors.initials: T
authors.lastname: Herman
authors.forename: I I
authors.initials: II
authors.lastname: Reider-Groswasser
authors.forename: T
authors.initials: T
authors.lastname: Gurevich
authors.forename: J M
authors.initials: JM
authors.lastname: Hausdorff
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology; D003430:Cross-Sectional Studies; D003710:Demography; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D005684:Gait / Q000502:physiology*; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D008609:Mental Status Schedule / Q000706:statistics & numerical data; D009069:Movement Disorders / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011597:Psychomotor Performance; D012307:Risk Factors
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