Poly(ethylene glycol) (PEG) enhances dynamic surface activity of a bovine lipid extract surfactant (BLES).
Shortage or malfunction of pulmonary surfactant in alveolar space leads to a critical condition termed respiratory distress syndrome (RDS). Surfactant replacement therapy, the major method to treat RDS, is an expensive treatment. In this paper, the effect of poly(ethylene glycol) (PEG) to improve dynamic surface activity of a bovine lipid extract surfactant (BLES) was studied by axisymmetric drop shape analysis (ADSA) and a captive bubble method. The activity of BLES+PEG mixtures was compared to that of a natural surfactant containing surfactant proteins A and D. When PEG was added into BLES mixtures, the surface tension hysteresis of BLES films was minimized when the films were compressed by more than 50%. PEG also helps to quickly restore surfactant films after film collapse. Thus, as far as surface tension effects go, the findings suggest that PEG might be used as a substitute for surfactant-associated protein SP-A in therapeutic surfactant products, and might also be used to reduce the amount of BLES required in clinical applications.
Lu
James J
JJ
Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, Ont., Canada M5S 3G8.
Yu
Laura M Y
LM
Cheung
Wendy W Y
WW
Goldthorpe
Irene A
IA
Zuo
Yi Y
YY
Policova
Zdenka
Z
Cox
Peter N
PN
Neumann
A Wilhelm
AW
D000818:Animals; D002417:Cattle; D006801:Humans; D007700:Kinetics; D010743:Phospholipids / Q000737:chemistry* / Q000302:isolation & purification; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011663:Pulmonary Surfactants / Q000737:chemistry*; D012128:Respiratory Distress Syndrome; D013314:Stress, Mechanical; D013500:Surface Tension
D010743:Phospholipids; D011663:Pulmonary Surfactants; D011092:Polyethylene Glycols