Atopy parameters in asthmatic children increase with accumulation of null-alleles of glutathione-S-transferase M1.
Atopy parameters (total IgE, skin prick test, and peripheral blood eosinophil count) in children with atopic bronchial asthma depend on the number of glutathione-S-transferase M1 mutant alleles in the genotype and on family history of asthma.
Makarova
S I
SI
Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. makar@soramn.ru
Safronova
O G
OG
Vavilin
V A
VA
Batychko
O A
OA
Gavalov
S M
SM
Lyakhovich
V V
VV
D000483:Alleles; D001249:Asthma / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D002648:Child; D004804:Eosinophils; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D012882:Skin Tests
D005982:Glutathione Transferase; D007073:Immunoglobulin E