A case of melioidosis presenting as migrating pulmonary infiltration: the first case in Korea.
Melioidosis is an infection of the Gram-negative bacterium Burkholderia pseudomallei. While it is known as an important cause of sepsis or chronic abscess-forming disease in Southeast Asia and northern Australia, no case has yet been reported in Korea. A 50-yr-old man visited our hospital for intermittent fever associated with dry cough and sputum. Roentgenographic examination showed migrating pulmonary infiltration. Symptoms and chest radiograph and computed tomography (CT) image findings did not improve despite use of fluoroquinolone antibiotics. Gram-negative bacteria were isolated on bronchoscopic washing culture and were identified as B. pseudomallei on DNA sequencing of 16S ribosomal RNA with 100% homology. Treatment for melioidosis was commenced with high dose ceftazidime, and the patient's fever, cough, and sputum were improved and the lesion on chest radiograph and CT almost disappeared.
Lee
Sei Won
SW
Division of Pulmonary and Critical Care Medicine, Seoul National University College of Medicine, Seoul, Korea.
Yi
Jongyoun
J
Joo
Sae-Ik
SI
Kang
Young Ae
YA
Yoon
Young Soon
YS
Yim
Jae Joon
JJ
Yoo
Chul-Gyu
CG
Han
Sung Koo
SK
Shim
Young-Soo
YS
Kim
Eui-Chong
EC
Kim
Young Whan
YW
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016957:Burkholderia pseudomallei / Q000378:metabolism; D002442:Ceftazidime / Q000494:pharmacology; D003937:Diagnosis, Differential; D024841:Fluoroquinolones / Q000494:pharmacology; D006801:Humans; D007723:Korea; D008168:Lung / Q000382:microbiology*; D008171:Lung Diseases / Q000175:diagnosis / Q000382:microbiology*; D008297:Male; D008554:Melioidosis / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D012336:RNA, Ribosomal, 16S / Q000737:chemistry; D018805:Sepsis; D017422:Sequence Analysis, DNA; D013696:Temperature; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D012336:RNA, Ribosomal, 16S; D002442:Ceftazidime
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