Potassium-selective membrane electrodes based on macrocyclic metacyclophanes analogous to calixarenes.
The tetrabutyl ester derived from 9,16,25,32-tetrahydroxy[3.1.3.1]metacyclophane was an excellent ionophore for constructing a K+-selective membrane electrode. This ionophore exhibited a much higher selectivity toward K+ than the structurally similar potassium ionophore IV commercially available from Fluka. In particular, the interference from organic ammonium ions decreased remarkably. Potassium ionophore IV possessed oxygen atoms in the ring structure, while the present ionophore changed the oxygen atoms to carbon atoms. Thus, the removal of oxygen atoms in ring constituents of the metacyclophane acted to reduce the interaction with the NH3+ group of organic ammonium ions. The size of the cavity of the present ionophore was between those of calix[4]arene and calix[6]arene derivatives, which act as Na+ and Cs+ ionophores, respectively, demonstrating that the ability to recognize alkali metal cations was strongly cavity size-dependent. The present K+-selective electrode had less interference from Rb+ and Cs+ than an electrode constructed using valinomycin, but suffered greater interference from Na+.
Katsu
Takashi
T
Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700-8530, Japan.
Yokoyama
Yuutaku
Y
Ueda
Keisuke
K
Kohno
Kazufumi
K
Yamato
Takehiko
T
D047250:Calixarenes / Q000737:chemistry*; D004566:Electrodes; D047028:Macrocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D011188:Potassium / Q000737:chemistry*; D012680:Sensitivity and Specificity
D047028:Macrocyclic Compounds; D047250:Calixarenes; D011188:Potassium