title: Recognizing and managing patients with irritable bowel syndrome.
abstract: OBJECTIVE
  To address the diagnosis and clinical management of irritable bowel syndrome (IBS) and provide a discussion of the available serotonergic agents.
  
  
  METHODS
  Recent studies examining the pathophysiology of IBS.
  
  
  CONCLUSIONS
  Diagnostic testing may be required in the subset of patients with IBS who present with alarm symptoms, or "red flags," suggestive of underlying organic disease. An important role has been suggested for the neurotransmitter serotonin in both gut motility and visceral pain sensitivity.
  
  
  CONCLUSIONS
  A diagnosis of IBS is largely based on symptoms; therefore, effective clinician-patient communication and careful attention to details of patient presentation, history, and physical examination are essential.
authors.affiliation: Seattle Gastroenterology Associates, Seattle, Washington, USA. acroghan@u.washington.edu
authors.forename: Anne
authors.initials: A
authors.lastname: Croghan
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Heitkemper
mesh_terms: D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis* / Q000628:therapy*