Functional neuroimaging of primary headache disorders.
Until recently, primary headache disorders such as migraine and cluster headache were considered to be vascular in origin. However, advances in neuroimaging techniques, such as positron emission tomography, single photon emission computerized tomography, and functional magnetic resonance imaging, have augmented the growing clinical evidence that these headaches are primarily driven from the brain. This review covers functional imaging studies in migraine, cluster headache, rarer headache syndromes, and experimental head pain. Together with newer techniques, such as voxel-based morphometry and magnetic resonance spectrometry, functional imaging continues to play a role in elucidating and targeting the neural substrates in each of the primary headache syndromes.
Cohen
Anna S
AS
Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Goadsby
Peter J
PJ
D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D003952:Diagnostic Imaging; D020773:Headache Disorders / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans
Neurology. 1998 Nov;51(5):1465-9
9818884
Neurology. 2002 Jul 9;59(1):72-8
12105310
Br J Pharmacol. 1997 Nov;122(5):918-22
9384509
Ann Neurol. 1981 Apr;9(4):344-52
6784664
Nat Med. 1995 Jul;1(7):658-60
7585147
Ann Neurol. 1998 Feb;43(2):272
9485072
J Neurol Sci. 1996 Jun;138(1-2):60-5
8791240
Stroke. 1994 May;25(5):974-9
8165693
Headache. 1995 Mar;35(3):143-5
7721574
Pain. 1996 Feb;64(2):303-14
8740608
Cephalalgia. 1992 Jun;12(3):137-41; discussion 127
1623507
J Neurol Neurosurg Psychiatry. 1994 Oct;57(10 ):1166-72
7931375
Neurosci Lett. 2002 Oct 31;332(2):115-8
12384224
Eur J Neurol. 1994 Sep;1(1):35-43
24283427
Pain. 1997 Apr;70(2-3):185-91
9150292
Pain. 1997 Dec;73(3):431-45
9469535
Ann Neurol. 1999 Nov;46(5):791-4
10554000
Neurol Res. 2000 Apr;22(3):313-7
10769826
Brain. 1987 Aug;110 ( Pt 4):917-34
3651801
Headache. 2001 Jul-Aug;41(7):629-37
11554950
Acta Neurol Scand. 1987 Jan;75(1):1-8
3107334
Acta Neurol Belg. 1998 Jun;98 (2):190-4
9686279
Neurology. 2003 Feb 25;60(4):595-601
12601098
Headache. 1982 Nov;22(6):242-8
6983514
Ann Neurol. 1991 Jan;29(1):91-4
1996883
Acta Neurol Scand. 1976 Oct;54(4):371-4
973557
Somatosens Mot Res. 1993;10(3):297-308
8237217
Cephalalgia. 1987;7 Suppl 6:76-8
3442810
Headache. 2001 Mar;41(3):310-6
11264693
N Engl J Med. 1994 Dec 22;331(25):1689-92
7969360
Brain. 1994 Feb;117 ( Pt 1):199-210
7908596
J Neurophysiol. 1994 Feb;71(2):802-7
8176441
Neurology. 2000 Nov 14;55(9):1328-35
11087776
Brain. 1984 Jun;107 ( Pt 2):447-61
6609739
Headache. 1980 Jul;20(4):184-9
7390799
Nat Med. 1999 Jul;5(7):836-8
10395332
Lancet. 2001 Mar 31;357(9261):1016-7
11293599
Headache. 2002 Feb;42(2):132-5
12005288
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4687-92
11287655
Science. 1992 Jan 10;255(5041):215-6
1553549
Cephalalgia. 1981 Dec;1(4):209-16
7347624
Ann Neurol. 1990 Dec;28(6):791-8
2285266
Neurol Sci. 2003 May;24 Suppl 2:S143-5
12811614
Brain. 2003 Jan;126(Pt 1):241-7
12477710
Pain. 1996 Sep;67(1):59-68
8895232
Ann Neurol. 1983 Jun;13(6):633-41
6881926
Eur J Neurol. 2003 Jan;10(1):53-7
12534993
Arch Neurol. 1999 May;56(5):548-54
10328249
Cephalalgia. 1984 Mar;4(1):17-23
6424945
Headache. 1991 Jun;31(6):365-71
1889975
Cephalalgia. 2002 Mar;22(2):107-11
11972577
Ann Neurol. 1998 Jan;43(1):25-31
9450765
Headache. 1983 Nov;23(6):258-65
6643036
Pain. 1998 Jan;74(1):61-6
9514561
J Cereb Blood Flow Metab. 2001 Oct;21(10 ):1171-6
11598494
Microsc Res Tech. 2001 May 1;53(3):179-87
11301493
Headache. 1987 Sep;27(8):416-20
3667258
Lancet. 1998 Jul 25;352(9124):275-8
9690407
Cephalalgia. 1988;8 Suppl 7:1-96
3048700
J Neurosci. 1994 Jul;14 (7):4095-108
8027764
Lancet. 1991 Jul 6;338(8758):13-7
1676084
Lancet Neurol. 2002 Aug;1(4):251-7
12849458
J Neurol Neurosurg Psychiatry. 2002 Aug;73(2):202-3
12122185
Br Med Bull. 2003;65:223-34
12697628
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
10860804