title: Rapid and efficient synthesis of 1,2,4-oxadiazoles utilizing polymer-supported reagents under microwave heating.
abstract: 1,2,4-Oxadiazoles can be rapidly and efficiently synthesized from a variety of readily available carboxylic acids and amidoximes using either method A or method B. The use of commercially available polymer-supported reagents combined with microwave heating resulted in high yields and purities of the product 1,2,4-oxadiazoles in an expeditious manner. [structure: see text]
authors.affiliation: High-Throughput Organic Synthesis Group, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6113, USA. wang.ying@abbott.com
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Reagan L
authors.initials: RL
authors.lastname: Miller
authors.forename: Daryl R
authors.initials: DR
authors.lastname: Sauer
authors.forename: Stevan W
authors.initials: SW
authors.lastname: Djuric
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D007202:Indicators and Reagents; D008872:Microwaves; D015394:Molecular Structure; D010069:Oxadiazoles / Q000032:analysis / Q000138:chemical synthesis*; D010091:Oximes / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D007202:Indicators and Reagents; D010069:Oxadiazoles; D010091:Oximes