title: Functional disconnection of the semantic networks in schizophrenia.
abstract: Patients with schizophrenia exhibit deficits in semantic processing, which can form the basis of thought disorders. The objective of this study was to explore functional connectivity between the activated areas during semantic processing in schizophrenia. Twelve patients with schizophrenia and 12 healthy controls were studied with [15O]H2O positron-emission tomography during semantic judgment. The expected activation in the left inferior occipitotemporal cortex significantly correlated with several other regional activations in normal study participants, but with no other regional activations in patients with schizophrenia. This finding suggests that schizophrenia involves a disconnection of semantic networks. The resultant distortion in semantic processing may have an impact on thought disorders.
authors.affiliation: Department of Psychiatry, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, Korea.
authors.forename: Jae-Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Jeong
authors.initials: J
authors.lastname: Ho Seok
authors.forename: Hae-Jeong
authors.initials: HJ
authors.lastname: Park
authors.forename: Dong
authors.initials: D
authors.lastname: Soo Lee
authors.forename: Myung
authors.initials: M
authors.lastname: Chul Lee
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwon
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*