title: A 32-year experience with surgical repair of sinus of valsalva aneurysms.
abstract: BACKGROUND
  Sinus of Valsalva (SoV) aneurysms are rare (0.15% to 1.5% CPB cases) and five times more frequent in Asians. Usually congenital, SoV aneurysms arise from the right or noncoronary sinus, are associated with other cardiac defects, and are repaired primarily or with a patch. Acquired SoV aneuryms develop secondary to infection or trauma. Here, we describe our 32-year experience with SoV aneurysm repair in a Western population.
  
  
  METHODS
  A retrospective review identified 22 patients who underwent SoV aneurysm repair between 1971 and 2003. Data is presented as mean +/- standard error (median).
  
  
  RESULTS
  Dyspnea was the most common presenting symptom. Nineteen of 22 patients were ruptured at the time of operation; three were found incidentally. Fifteen patients had associated cardiac defects including ventricular septal defect (VSD) (6), aortic insufficiency (6), and coarctation (3). One patient, repaired primarily, required reoperation for recurrence. All other patients underwent patch repair. The operative survival was 95% (21/22). There were five known late deaths at 6.6 +/- 2.3 (5.7) years post-repair. Five and ten year survival rates were 84.9 +/- 11% and 59.4 +/- 17%, respectively.
  
  
  CONCLUSIONS
  Observed differences in the sinus of origin, age at presentation, associated cardiac malformations, and mortality in our Western series versus previous Asian cohort studies likely reflect a racial disparity and higher prevalence of acquired versus congenital SoV aneurysms. We recommend a thorough search for a VSD in all cases and use of patch repair, regardless of size, to reduce risk of recurrence.
authors.affiliation: Division of Cardiac Surgery, The Johns Hopkins Hospital, Baltimore, MD 21287-4618, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Harkness
authors.forename: Torin P
authors.initials: TP
authors.lastname: Fitton
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Barreiro
authors.forename: Diane
authors.initials: D
authors.lastname: Alejo
authors.forename: Vincent L
authors.initials: VL
authors.lastname: Gott
authors.forename: William A
authors.initials: WA
authors.lastname: Baumgartner
authors.forename: David D
authors.initials: DD
authors.lastname: Yuh
mesh_terms: D000328:Adult; D005260:Female; D006322:Heart Aneurysm / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D012850:Sinus of Valsalva / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis; D013997:Time Factors