Microtubule cytoskeleton: a new twist at the end.
A diverse group of proteins known as +TIPs specifically recognize the growing plus ends of microtubules in cells. Two recent papers on one such protein, CLIP-170, provide new insights into the cellular functions of +TIPs as well as the mechanism by which they track microtubule ends.
Wittmann
Torsten
T
The Scripps Research Institute, Department of Cell Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. twittman@scripps.edu
Desai
Arshad
A
D003599:Cytoskeleton / Q000378:metabolism*; D004398:Dyneins / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D008954:Models, Biological; D009363:Neoplasm Proteins; D011485:Protein Binding; D015003:Yeasts
D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; C076744:cytoplasmic linker protein 170; D004398:Dyneins