title: Peptide-cleaving catalyst selective for peptide deformylase.
abstract: A peptide-cleaving catalyst selective for peptide deformylase (PDF) was obtained from a library containing about 15 000 catalyst candidates. The catalyst cleaved the polypeptide backbone of PDF at Gln(152)-Arg(153). Docking simulations suggested multiple modes of interactions in the complex formed between the catalyst and PDF.
authors.affiliation: Department of Chemistry, Seoul National University, Seoul 151-747, Korea.
authors.forename: Pil Seok
authors.initials: PS
authors.lastname: Chae
authors.forename: Myoung-Soon
authors.initials: MS
authors.lastname: Kim
authors.forename: Chul-Seung
authors.initials: CS
authors.lastname: Jeung
authors.forename: Seong Du
authors.initials: SD
authors.lastname: Lee
authors.forename: Hwangseo
authors.initials: H
authors.lastname: Park
authors.forename: Sangyoub
authors.initials: S
authors.lastname: Lee
authors.forename: Junghun
authors.initials: J
authors.lastname: Suh
mesh_terms: D000577:Amides / Q000737:chemistry*; D000581:Amidohydrolases / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry*; D011487:Protein Conformation; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D000577:Amides; D009942:Organometallic Compounds; C442399:cyclencobalt(III); D003035:Cobalt; D000581:Amidohydrolases; C084507:peptide deformylase