title: Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin.
abstract: Chemerin is a chemotactic agent that was recently identified as the ligand of ChemR23, a serpentine receptor expressed by activated macrophages and monocyte-derived dendritic cells (DCs). This paper shows that blood plasmacytoid and myeloid DCs express functional ChemR23. Recombinant chemerin induced the transmigration of plasmacytoid and myeloid DCs across an endothelial cell monolayer. In secondary lymphoid organs (lymph nodes and tonsils), ChemR23 is expressed by CD123(+) plasmacytoid DCs and by CD1a(+) DC-SIGN(+) DCs in the interfollicular T cell area. ChemR23(+) DCs were also observed in dermis from normal skin, whereas Langerhans cells were negative. Chemerin expression was selectively detected on the luminal side of high endothelial venules in secondary lymphoid organs and in dermal endothelial vessels of lupus erythematosus skin lesions. Chemerin(+) endothelial cells were surrounded by ChemR23(+) plasmacytoid DCs. Thus, ChemR23 is expressed and functional in plasmacytoid DCs, a property shared only by CXCR4 among chemotactic receptors. This finding, together with the selective expression of the cognate ligand on the luminal side of high endothelial venules and inflamed endothelium, suggests a key role of the ChemR23/chemerin axis in directing plasmacytoid DC trafficking.
authors.affiliation: Department of Pathology, University of Brescia, 25123 Brescia, Italy.
authors.forename: William
authors.initials: W
authors.lastname: Vermi
authors.forename: Elena
authors.initials: E
authors.lastname: Riboldi
authors.forename: Valerie
authors.initials: V
authors.lastname: Wittamer
authors.forename: Francesca
authors.initials: F
authors.lastname: Gentili
authors.forename: Walter
authors.initials: W
authors.lastname: Luini
authors.forename: Simona
authors.initials: S
authors.lastname: Marrelli
authors.forename: Annunciata
authors.initials: A
authors.lastname: Vecchi
authors.forename: Jean-Denis
authors.initials: JD
authors.lastname: Franssen
authors.forename: David
authors.initials: D
authors.lastname: Communi
authors.forename: Luisa
authors.initials: L
authors.lastname: Massardi
authors.forename: Marina
authors.initials: M
authors.lastname: Sironi
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.forename: Marc
authors.initials: M
authors.lastname: Parmentier
authors.forename: Fabio
authors.initials: F
authors.lastname: Facchetti
authors.forename: Silvano
authors.initials: S
authors.lastname: Sozzani
mesh_terms: D002465:Cell Movement; D002478:Cells, Cultured; D018925:Chemokines / Q000096:biosynthesis / Q000494:pharmacology; D002630:Chemotactic Factors / Q000096:biosynthesis / Q000494:pharmacology; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology* / Q000473:pathology; D008221:Lymphoid Tissue / Q000098:blood supply* / Q000276:immunology / Q000378:metabolism; D022423:Myeloid Cells / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology; D019707:Receptors, Chemokine / Q000096:biosynthesis / Q000502:physiology*; D012867:Skin / Q000098:blood supply* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D014699:Venules / Q000276:immunology / Q000378:metabolism
chemical_list: C102741:CMKLR1 protein, human; D018925:Chemokines; D002630:Chemotactic Factors; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; C478630:RARRES2 protein, human; D019707:Receptors, Chemokine
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