title: Lingual ulcer as the only sign of recurrent mycobacterial infection in an HIV/AIDS-infected patient.
abstract: The report describes an HIV/AIDS patient seen at a referral center in Mexico City, in whom a mycobacterial infection in the oral mucosa, probably tuberculosis (TB) was identified. The purpose is to describe the clinical and histological findings in an HIV-infected patient, who after being treated successfully for tuberculous lymphangitis 4 years ago, presented with a lingual ulcer as the only suggestive sign of recurrence of mycobacterial infection, probably M. tuberculosis. A 39-year-old man seen in the HIV clinic of the Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" in Mexico City since 1991 for HIV infection. In 1999 the patient developed tuberculous lymphangitis; he was managed with a 4-drug regimen for 12 months, with improvement of local and systemic symptoms. In May of 2003, the patient presented a painful superficial lingual ulcer, 0.7 cm in diameter, well circumscribed, crateriform with slightly elevated, irregular and indurated borders, of 4 months duration. The histopathological examination showed chronic granulomatous inflammation with giant multinucleated cells, suggestive of mycobacterial infection, and recurrence of TB was considered. Rifampin, isoniazide, pyrazinamide, ethambutol and streptomycin were administered. The lingual lesion improved with partial healing at the first week and total remission at 45 days after the beginning of the antituberculous treatment. In June, 2003, the patient began highly active antiretroviral therapy (HAART) that included two NRTIs and one NNRTI. At 7 months of follow-up, the patient remains free of lingual lesions. The particularity of the present case is that the lingual ulcer was the only sign of infection by mycobacteria, suggestive of TB, in an HIV/AIDS patient that probably represented a recurrence of a previous episode.
authors.affiliation: Universidad Autónoma Metropolitana-Xochimilco. veliaram@hotmail.com
authors.forename: Velia
authors.initials: V
authors.lastname: Ramírez-Amador
authors.forename: Gabriela
authors.initials: G
authors.lastname: Anaya-Saavedra
authors.forename: Imelda
authors.initials: I
authors.lastname: González-Ramírez
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Mosqueda-Gómez
authors.forename: Lilly
authors.initials: L
authors.lastname: Esquivel-Pedraza
authors.forename: Edgardo
authors.initials: E
authors.lastname: Reyes-Gutiérrez
authors.forename: Juan
authors.initials: J
authors.lastname: Sierra-Madero
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D000995:Antitubercular Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008800:Mexico; D009061:Mouth Mucosa / Q000473:pathology; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D019226:Oral Ulcer / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D012008:Recurrence; D014059:Tongue / Q000382:microbiology / Q000473:pathology; D014060:Tongue Diseases / Q000209:etiology / Q000382:microbiology / Q000473:pathology*; D014388:Tuberculosis, Lymph Node / Q000473:pathology; D014393:Tuberculosis, Oral / Q000150:complications / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000995:Antitubercular Agents