[Protective effects of polysacchride of Spirulina platensis and Sargassum thunbeergii on vascular of alloxan induced diabetic rats].
OBJECTIVE
To study the protective effects of polysaccharide of Spirulina platensis and Sargassum thunbeergii on vascular of alloxan (ALX) induced diabetic rats.


METHODS
With the doses of polysaccharide of Spirulina platensis (PSP) and Sargassum thunbeergii (PST) compound (1:1) 12.261, 36.783, 110.349 mg x kg(-1) by i.g. administration to alloxan induced diabetic rats respectively for 6 weeks. Then the blood glucose and the TC, HDL-C, TG, NO, ET in serum were detected. The contraction and relaxation response to NE and ACh in aortic rings of the alloxan induced diabetic rats has been studied.


RESULTS
The results showed the compound of PSP and PST could decrease the blood glucose and the TC, TG, NO, ET in serum and increase HDL-C than in the alloxan induced diabetic rats. The contraction responses to NE in aortic rings of the alloxan induced diabetic rats were significantly elevated in the normal rats, and the responses to ACh were significantly lower. PSP and PST compound could significantly lower the responses to NE and significantly elevate the responses to ACh in aortic rings of the alloxan induced diabetic rats.


CONCLUSIONS
PSP and PST compound could decrease blood glucose and could protect the vascular of alloxan induced diabetic rats.
Huang
Zhi-xuan
ZX
School of Pharmaceutical Sciences, SunYat-sen University, Guangzhou 510275, China.
Mei
Xue-ting
XT
Xu
Dong-hui
DH
Xu
Shi-bo
SB
Lv
Jun-yi
JY
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D000458:Cyanobacteria / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D016232:Endothelins / Q000097:blood; D005260:Female; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009569:Nitric Oxide / Q000097:blood; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D044647:Sargassum / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008076:Cholesterol, HDL; D016232:Endothelins; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; D020011:Protective Agents; D014280:Triglycerides; D009569:Nitric Oxide; D002784:Cholesterol