Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes.
Conditions are reported for the facile, high-yielding coupling of acyl chlorides with terminal alkynes in a reaction involving palladium and copper iodide; the reaction is tolerant of a wide variety of acyl chlorides and terminal alkynes and provides a convenient one-pot route to acetylenic ketones.
Cox
Russell J
RJ
School of Chemistry, University of Bristol, Cantock's Close, Bristol, UKBS8 1TS. r.j.cox@bris.ac.uk
Ritson
Dougal J
DJ
Dane
Thomas A
TA
Berge
John
J
Charmant
Jonathan P H
JP
Kantacha
Anob
A
D000480:Alkynes / Q000737:chemistry* / Q000378:metabolism; D001565:Benzoates / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013696:Temperature
D000480:Alkynes; D001565:Benzoates; D007454:Iodides; D010165:Palladium; D003300:Copper; C073870:cuprous iodide; C013409:benzoyl chloride