Direct thrombin inhibitor use during percutaneous coronary intervention.
Direct thrombin inhibitors (DTI) are emerging as alternative anticoagulants to unfractionated heparin and indirect thrombin inhibitors in patients undergoing percutaneous coronary intervention (PCI). We review the pharmacological properties of these newer antithrombotic agents and evaluate the clinical data demonstrating their use in patients undergoing PCI.
Kokolis
Spyros
S
State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203, USA.
Clark
Luther T
LT
Cavusoglu
Erdal
E
Marmur
Jonathan D
JD
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D013917:Thrombin / Q000037:antagonists & inhibitors*
D000925:Anticoagulants; D006493:Heparin; D013917:Thrombin