title: Electrical brain-stimulation paradigm for estimating the seizure onset site and the time to ictal transition in temporal lobe epilepsy.
abstract: OBJECTIVE
  To explore and validate a novel stimulation and analysis paradigm proposed to monitor spatial distribution and temporal changes of the excitability state in patients with temporal lobe epilepsy (TLE).
  
  
  METHODS
  We use intermittent pulse stimulation in the frequency range 10-20Hz. A quantitative measure of spectral phase de-modulation, the relative phase clustering index (rPCI) was applied to the evoked EEG signals, measured from electrodes implanted in the hippocampal formation.
  
  
  RESULTS
  We found that in the interictal periods, high values of rPCI recorded from specific sites were correlated with the most probable seizure onset sites (SOS). Furthermore we found that high values of rPCI from certain locations correlated with shorter time intervals to the next seizure.
  
  
  CONCLUSIONS
  Our clinical findings indicate that although the precise moment of ictal transitions is in general unpredictable, it may be possible to estimate the probability of occurrence of some epileptic seizures.
  
  
  CONCLUSIONS
  The use of the rPCI for probabilistic forecasting of upcoming epileptic seizures is warranted. rPCI measurements may be used to guide interventions with the aim of modifying local tissue excitability that ultimately might prevent ictal transitions.
authors.affiliation: Medical Physics Department, Dutch Epilepsy Clinics Foundation, Achterweg 5, 2103 SW Heemstede, The Netherlands. skalitzin@sein.nl
authors.forename: S
authors.initials: S
authors.lastname: Kalitzin
authors.forename: D
authors.initials: D
authors.lastname: Velis
authors.forename: P
authors.initials: P
authors.lastname: Suffczynski
authors.forename: J
authors.initials: J
authors.lastname: Parra
authors.forename: F Lopes
authors.initials: FL
authors.lastname: da Silva
mesh_terms: D001931:Brain Mapping; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000628:therapy*; D005071:Evoked Potentials / Q000528:radiation effects; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000528:radiation effects; D006801:Humans; D008297:Male; D008959:Models, Neurological; D011237:Predictive Value of Tests; D013702:Temporal Lobe / Q000503:physiopathology / Q000528:radiation effects*; D013997:Time Factors