Laboratory approaches to the diagnosis of hepatitis C virus infection.
Hepatitis C virus (HCV) infection is a major and growing health problem worldwide. Laboratory testing plays an important role in the response to the HCV epidemic. Serologic tests for antibody to HCV are useful for screening purposes. The mainstays of laboratory testing for HCV, however, are the molecular approaches. Qualitative molecular tests are useful for confirmation of positive screening tests. Quantitative molecular tests provide prognostic information regarding the likelihood of response to therapy, and allow the monitoring of treatment efficacy. Similarly, genotyping assays predict response to therapy, and allow rational decisions regarding duration of treatment. The combination of continually improving laboratory testing, together with new drugs targeting distinct molecular determinants that are either essential or important in the viral replication cycle, is likely to lead to dramatic improvements in the management of HCV disease.
Jerome
K R
KR
Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA 98366, USA.
Gretch
D R
DR
D005838:Genotype; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis
D012367:RNA, Viral