[Study on the teratogenicity effects of genetically modified rice with Xa21 on rats].
OBJECTIVE
To observe the effects of genetically modified rice with Xa21 on the development of rat embryos.


METHODS
According to sex, weanling rats were divided into four groups: transgenic rice group, non-transgenic rice group, AIN93G negative control group and MATDA positive control group. The rats were fed with corresponding food for 90 days and mated. The development of maternal rats and embryos were observed.


RESULTS
The body weight gain of pregnant rats and the body weight, body length and tail length of fetal rats in transgenic rice group were significant increased than those in positive control group. The number of death embryos and adsorption embryos, the malformation rate (appearance, viscera, skeleton) in transgenic rice group were lower than those in positive control group. There were no significant difference of all indicators among transgenic rice group, non-transgenic rice group and AIN93G negative control group.


CONCLUSIONS
Compared with the non-transgenic rice, transgenic rice modified with Xa21 gene showed no significant differences in rat pregnant rate and embryo development.
Li
Yinghua
Y
National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Piao
Jianhua
J
Zhuo
Qin
Q
Chen
Xiaoping
X
Mao
Deqian
D
Yang
Lichen
L
Yang
Xiaoguang
X
D000818:Animals; D047108:Embryonic Development; D005260:Female; D008297:Male; D012275:Oryza / Q000235:genetics* / Q000633:toxicity; D030821:Plants, Genetically Modified / Q000633:toxicity; D011247:Pregnancy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain