Synthesis of a beta-amino acid pharmacophore via a beta-lactam intermediate.
A stereoselective synthesis of (R)-beta-amino acid 1 via a beta-lactam intermediate is discussed.
Angelaud
Rémy
R
Merck Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. remy_angelaud@merck.com
Zhong
Yong-Li
YL
Maligres
Peter
P
Lee
Jaemoon
J
Askin
David
D
D000215:Acylation; D000596:Amino Acids / Q000138:chemical synthesis*; D015195:Drug Design; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D047090:beta-Lactams / Q000138:chemical synthesis / Q000737:chemistry*
D000596:Amino Acids; D047090:beta-Lactams