Combinatorial screening employing nylon loops and micro-X-ray powder diffraction.
A combinatorial screening method is described that employs nylon loops and micro-X-ray powder diffraction. The nylon loops are used to position the sample in a three-circle X-ray diffractometer in such a way as to allow for Gandolfi-like scans. These scans maximize mechanical tumbling of the sample, which in turn results in higher quality data. The diffractometer utilizes a pinhole source and two-dimensional area detection for rapid data collection. The method can be readily automated by employing single-crystal screening procedures. The combinatorial analysis of the three known polymorphs of D-mannitol is discussed and a simple procedure to produce all three polymorphs from the same starting solutions is presented.
Reibenspies
Joseph H
JH
Department of Chemistry, Texas A&M University, College Station, TX 77842, USA. j-reibenspies@tamu.edu
Bhuvanesh
Nattamai S P
NS
D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation* / Q000379:methods*; D009757:Nylons; D033362:Powder Diffraction / Q000295:instrumentation / Q000379:methods*; D014961:X-Ray Diffraction / Q000295:instrumentation / Q000379:methods
D009757:Nylons