A novel engineered peptide, a narrow-spectrum antibiotic, is effective against vancomycin-resistant Enterococcus faecalis.
A novel antienterococcal peptide was prepared by fusing the enterococcal cCF10 pheromone to the channel-forming domain of colicin Ia, forming Enterococcus faecalis pheromonicin (PMC-EF). This peptide was bactericidal against vancomycin-resistant Enterococcus faecalis (VRE) organisms. Electron microscopy and vital dyes confirmed increased membrane permeability. All mice made bacteremic with VRE strains survived when they were treated with PMC-EF, while all controls died.
Qiu
Xiao-Qing
XQ
Laboratory of Biomembrane and Membrane Protein, West China Hospital, Chengdu, People's Republic of China.
Zhang
Jie
J
Wang
He
H
Wu
George Y
GY
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001483:Base Sequence; D003087:Colicins / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010455:Peptides; D015202:Protein Engineering; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D003087:Colicins; D010455:Peptides
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