New integron-associated gene cassette encoding a 3-N-aminoglycoside acetyltransferase.
A fifth gene cassette containing an aacC gene, aacCA5, was found in an aacCA5-aadA7 cassette array in a class 1 integron isolated from a multiply drug resistant Salmonella enterica serovar Kentucky strain. The AacC-A5 or AAC(3)-Ie acetyltransferase encoded by aacCA5 is related to other AAC(3)-I enzymes and confers resistance to gentamicin.
Levings
Renee S
RS
Department of Biological Sciences, Macquarie University, Sydney, Australia.
Partridge
Sally R
SR
Lightfoot
Diane
D
Hall
Ruth M
RM
Djordjevic
Steven P
SP
D000123:Acetyltransferases / Q000235:genetics*; D000595:Amino Acid Sequence; D000617:Aminoglycosides / Q000494:pharmacology; D001483:Base Sequence; D024881:Drug Resistance, Bacterial / Q000235:genetics; D032023:Integrons; D008969:Molecular Sequence Data; D019779:Salmonella enterica / Q000187:drug effects / Q000235:genetics*
D000617:Aminoglycosides; D000123:Acetyltransferases; C019681:aminoglycoside acetyltransferase
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