Study of the evolution and degradation products of ciprofloxacin and oxolinic acid in river water samples by HPLC-UV/MS/MS-MS.
The results of a degradation study of the (fluoro)quinolone antibiotics ciprofloxacin and oxolinic acid in river water samples are presented in this paper. The decomposition of these compounds at ambient temperature was monitored during five months by HPLC-UV, and two consecutive degradation processes (photo- and bio/chemical-degradation) were observed in both cases although with different degradation rates. Ciprofloxacin was completely degraded after 3 months whereas 80% of oxolinic acid remained unaltered after five months of storage. The analysis of the degradation compounds formed was carried out using MS and tandem MS-MS, allowing the identification of four new ciprofloxacin transformation products not previously described in the literature. Possible degradation pathways for this antibiotic in river water are proposed.
Turiel
Esther
E
Institute for Reference Materials and Measurements, Joint Research Centre, European Commission, Retieseweg, 2440 Geel, Belgium. turiel@inia.es
Bordin
Guy
G
Rodríguez
Adela R
AR
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D001673:Biodegradation, Environmental; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002939:Ciprofloxacin / Q000737:chemistry* / Q000378:metabolism; D004784:Environmental Monitoring; D013058:Mass Spectrometry; D010093:Oxolinic Acid / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D010777:Photochemistry; D045483:Rivers / Q000737:chemistry / Q000382:microbiology; D014466:Ultraviolet Rays; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000528:radiation effects
D000890:Anti-Infective Agents; D014874:Water Pollutants, Chemical; D002939:Ciprofloxacin; D010093:Oxolinic Acid