title: Hazard functions and expected spike density functions for neuron spike activity in the cochlear nucleus of the cat.
abstract: The goal of these experiments was to evaluate the effect of stimulus evoked input and post spike refractoriness on the shapes of post stimulus time histograms (PSTHs). The time courses of spontaneous and/or evoked activity were studied in 153 neurons located predominantly in the dorsal cochlear nucleus in cats anesthetized with Nembutal. Tone bursts were presented to the ipsilateral ear in a free sound field. About half the cells were characterized by the pauser/build-up type of PSTH. Marked refractoriness was evidenced by relatively long recovery times of the hazard functions of spontaneous and tone-evoked spike activity. On presentation of tonal bursts, the time dependence of the probability of the first spike in the absence of a preceding spike (expected spike density function) was greater than the PSTH (actual spike density function). The initial PSTH peak with pause was shaped primarily by stimulus evoked input, whereas refractoriness tended to diminish the build-up portion of the PSTH. In chopper cells, PSTH peaks were usually not reflected in expected spike density functions showing that post spike refractoriness plays a major role in shaping the PSTH. In primary-like cells, refractoriness was small and had little effect on the shape of the PSTH. Some presumptively inhibitory cells showed a tendency to burst discharges with non-monotonic hazard functions. A very small number of cells showed a tendency to internal tuning to a defined signal periodicity.
authors.affiliation: The N. N. Andreev Acoustic Institute, 117036 Moscow, Russia.
authors.forename: N
authors.initials: N
authors.lastname: Bibikov
authors.forename: T
authors.initials: T
authors.lastname: Imig
authors.forename: F
authors.initials: F
authors.lastname: Samson
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002415:Cats; D017626:Cochlear Nucleus / Q000166:cytology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors
references.citation: J Neurophysiol. 1976 Mar;39(2):282-300
references.pmid: 1255224
references.citation: Exp Brain Res. 1973 Jun 29;17(4):402-27
references.pmid: 4725899
references.citation: Trends Neurosci. 2000 May;23(5):216-22
references.pmid: 10782127
references.citation: J Neurophysiol. 1978 Sep;41(5):1165-82
references.pmid: 212537
references.citation: J Comp Neurol. 1994 Oct 8;348(2):261-76
references.pmid: 7814691
references.citation: J Neurophysiol. 2002 May;87(5):2505-19
references.pmid: 11976387
references.citation: Exp Brain Res. 1983;52(3):333-55
references.pmid: 6653696
references.citation: J Neurophysiol. 1994 Mar;71(3):914-30
references.pmid: 8201432
references.citation: J Comp Neurol. 1975 Jul 15;162(2):269-84
references.pmid: 1150922
references.citation: J Neurophysiol. 1985 Oct;54(4):917-39
references.pmid: 4067627
references.citation: J Neurophysiol. 1999 Dec;82(6):3434-57
references.pmid: 10601474
references.citation: J Neurophysiol. 1993 May;69(5):1409-21
references.pmid: 8389823
references.citation: J Neurophysiol. 1993 May;69(5):1384-97
references.pmid: 8389821
references.citation: J Neurophysiol. 1992 May;67(5):1247-63
references.pmid: 1597710
references.citation: J Neurophysiol. 1987 Feb;57(2):414-42
references.pmid: 3559686
references.citation: Brain Res. 1978 Jun 9;148(1):43-65
references.pmid: 656932
references.citation: J Neurophysiol. 2000 Feb;83(2):907-25
references.pmid: 10669504
references.citation: J Neurosci. 1998 May 15;18(10):3955-66
references.pmid: 9570822
references.citation: Exp Neurol. 1980 Sep;69(3):576-88
references.pmid: 7409065
references.citation: J Neurophysiol. 1982 Sep;48(3):856-73
references.pmid: 6290620
references.citation: Biophys J. 1967 Nov;7(6):759-77
references.pmid: 19210997
references.citation: J Acoust Soc Am. 1995 Apr;97(4):2405-13
references.pmid: 7714258
references.citation: Hear Res. 2000 Nov;149(1-2):216-22
references.pmid: 11033260
references.citation: J Neurophysiol. 1990 Nov;64(5):1590-610
references.pmid: 2283542
references.citation: J Physiol. 1988 Feb;396:535-48
references.pmid: 2457693
references.citation: J Neurosci. 1990 Jul;10(7):2338-51
references.pmid: 2376777
references.citation: Hear Res. 1990 Apr;45(1-2):95-113
references.pmid: 2345121
references.citation: Biofizika. 2001 May-Jun;46(3):545-56
references.pmid: 11449559
references.citation: J Comp Neurol. 1983 Feb 1;213(4):426-47
references.pmid: 6300199
references.citation: J Neurophysiol. 1997 May;77(5):2549-72
references.pmid: 9163376
references.citation: Biofizika. 1975 Sep-Oct;20(5):887-92
references.pmid: 1203277
references.citation: Exp Brain Res. 1975 Oct 24;23(4):367-86
references.pmid: 1183510
references.citation: Exp Brain Res. 1966;1(3):220-35
references.pmid: 5920550
references.citation: J Neurophysiol. 1988 Jul;60(1):1-29
references.pmid: 3404211
references.citation: Exp Neurol. 1972 Oct;37(1):131-51
references.pmid: 5077556
references.citation: J Neurophysiol. 1989 Dec;62(6):1303-29
references.pmid: 2600627
references.citation: J Neurophysiol. 2002 May;87(5):2520-30
references.pmid: 11976388
references.citation: J Neurophysiol. 1995 Feb;73(2):550-61
references.pmid: 7760117
references.citation: J Neurophysiol. 1986 Aug;56(2):287-307
references.pmid: 3760922
references.citation: Ann Biomed Eng. 1998 May-Jun;26(3):473-87
references.pmid: 9570230
references.citation: J Neurophysiol. 1980 Jul;44(1):76-96
references.pmid: 7420140
references.citation: J Neurophysiol. 1996 Sep;76(3):1667-88
references.pmid: 8890284
references.citation: Hear Res. 1992 Jul;60(2):115-42
references.pmid: 1639723