Efficacy of caspofungin in prophylaxis and treatment of an adult leukemic patient with invasive pulmonary aspergillosis in allogeneic stem cell transplantation.
Summary Invasive aspergillosis is a major problem in the management of immunocompromised patients, its prevalence is rising and it is still a major cause of death in this group. The clinical success rate with classical drugs is far away from expectations. New drugs are needed in the treatment of this complication. Belonging to the new class of echinocandins, caspofungin is a newly introduced and promising drug in this fatal situation. We report a patient with acute myeloid leukemia who had invasive pulmonary aspergillosis during induction therapy being treated with amphotericin B in first step and afterwards with caspofungin. The patient received consolidation therapy and allogeneic stem cell transplantation while using caspofungin, and did not experience any adverse effect related to drug. Many side effects, e.g. derangements in liver and kidney functions, hypokalemia, infusion-related side effects and especially thrombocytopenia, which are common with amphotericin B treatment are no longer problem with caspofungin. The efficacy of caspofungin in terms of regression of pulmonary lesions and control of fever is quite successful. The optimal therapies for opportunistic fungal infections are still debated, and further evaluation is needed.
Ifran
Ahmet
A
Kaptan
Kürşat
K
Beyan
Cengiz
C
D000208:Acute Disease; D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D000077336:Caspofungin; D054714:Echinocandins; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications* / Q000628:therapy; D055666:Lipopeptides; D008172:Lung Diseases, Fungal / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D008297:Male; D010456:Peptides, Cyclic / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D036102:Peripheral Blood Stem Cell Transplantation
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D000077336:Caspofungin