Norepinephrine transporter (NET) promoter and 5'-UTR polymorphisms: association analysis in panic disorder.
Several biochemical and pharmacological studies suggest that the catecholaminergic system involving the norepinephrine transporter (NET) is relevant for the pathogenesis of panic disorder. Three single nucleotide polymorphisms in the promoter or untranslated 5' region of the NET gene were investigated by means of RFLP analysis in a sample of 115 German patients with panic disorder and 115 matched controls. Statistical analysis failed to show association with the overall diagnosis of panic disorder. In the subgroup of patients with panic disorder without agoraphobia, however, two polymorphisms were found to be associated with the disease (G/C (rs2397771): p < 0.05; T/C (rs2242446): p < 0.01). While our data do not support a major function of the NET gene in the development of panic disorder, it may play a role in the subgroup of panic disorder without agoraphobia.
Lee
Yoo J
YJ
Department of Psychiatry, University of Münster, Albert-Schweitzer-Str. 11, D-48149 Münster, Germany.
Hohoff
Christa
C
Domschke
Katharina
K
Sand
Philipp
P
Kuhlenbäumer
Gregor
G
Schirmacher
Anja
A
Freitag
Christine M
CM
Meyer
Jobst
J
Stöber
Gerald
G
Franke
Petra
P
Nöthen
Markus M
MM
Fritze
Jürgen
J
Fimmers
Rolf
R
Garritsen
Henk S
HS
Stögbauer
Florian
F
Deckert
Jürgen
J
D020121:5' Untranslated Regions / Q000235:genetics*; D000328:Adult; D000379:Agoraphobia / Q000235:genetics; D000483:Alleles; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050484:Norepinephrine Plasma Membrane Transport Proteins; D016584:Panic Disorder / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D027981:Symporters / Q000235:genetics*
D020121:5' Untranslated Regions; D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human; D027981:Symporters