Biochemical serum profiles in dogs experimentally infected with Angiostrongylus vasorum (Baillet, 1866).
The biochemical profiles of crossbred dogs experimentally infected with the parasite Angiostrongylus vasorum were studied. Two groups of five dogs were experimentally inoculated with 50 and 100 third stage infective larvae (L3) of A. vasorum per kilogram of body weight. A third group of five uninfected animals were used as control. Serum from these animals were used for biochemical tests to measure total and fractioned proteins, urea, creatinine and to determine the activities of aspartate (AST), alanine (ALT) aminotransferase, gamma-glutamyl transferase (GGT), alkaline phosphatase (PAL) and creatine kinase isoenzyme MB (CK-MB). The alpha-1, alpha-2 and beta-globulins fractions showed alterations during acute phase of the infection. No modifications were observed in the biochemical profiles of ALT, AST, GGT, PAL, urea and creatinine. CK-MB was shown to be a good early indicator of cardiac injury in dogs experimentally infected with A. vasorum.
Cury
M C
MC
Av. Pará 1720, Bloco 4C, Laboratório de Parasitologia, Instituto de Ciências Biomédicas, Universidade Federal de Uberlândia, Bairro Umuarama, Uberlândia, Minas Gerais, Brazil. cury@umuarama.ufu.br
Guimarães
M P
MP
Lima
W S
WS
Caldeira
M C M
MC
Couto
T R
TR
Murta
K
K
Carvalho
M G
MG
Baptista
J M B
JM
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000801:Angiostrongylus / Q000254:growth & development*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000097:blood* / Q000201:enzymology / Q000469:parasitology*; D004285:Dogs; D005916:Globulins / Q000378:metabolism; D007527:Isoenzymes / Q000097:blood; D017206:Strongylida Infections / Q000097:blood* / Q000201:enzymology / Q000469:parasitology / Q000662:veterinary*; D014508:Urea / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D001798:Blood Proteins; D005916:Globulins; D007527:Isoenzymes; D014508:Urea; D003404:Creatinine; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; D000469:Alkaline Phosphatase
Vet Rec. 1980 Jan 26;106(4):83
7355562
Clin Chem. 1970 May;16(5):431-6
5443769
Cornell Vet. 1965 Jul;55:462-71
14343838
Ann Parasitol Hum Comp. 1973 Jul-Aug;48(4):567-96
4791829
Vet Rec. 1993 Dec 4;133(23):565-70
8303806
Am J Clin Pathol. 1957 Dec;28(6):681-8
13508589
Indian Vet J. 1971 Jun;48(6):633-40
5566713
Circulation. 1990 Sep;82(3):759-64
2203554
Parasitol Res. 1993;79(5):428-30
8415550
J Biol Chem. 1949 Feb;177(2):751-66
18110453
Am J Clin Pathol. 1957 Jul;28(1):56-63
13458125
Clin Chem. 1969 Feb;15(2):124-36
5773262
Am J Vet Res. 1970 Jan;31(1):131-43
5414275