"I will miss the study, God bless you all": participation in a nutritional chemoprevention trial.
Randomized controlled clinical trials are often considered to be the "gold standard" for health research. Consequently, understanding the reasons people participate in these trials, especially minority groups who are often under-represented in clinical trials, or populations who have chronic illnesses or abuse drugs, is salient for successful recruitment, retention, and project design. This paper describes the results of a study that was designed to examine some of the ways in which participants in a randomized double blind clinical trial perceived their participation in the clinical trial, and the reasons they gave for continuing in the study. All of the participants were individuals who were using drugs and were infected with the HIV-1 virus, and had participated in a chemoprevention trial. The data from an exit interview were analyzed thematically in order to reveal units of meaning concerning participation and continuation in the clinical trial. The analysis revealed 3 higher-level concepts, or themes, that guided participation: increased health awareness, personal enhancement, and sociability. The data clearly indicated that involvement and retention in the trial were directly related to the ways in which the participants interpreted the study, perceived the benefits they derived from participating, and imbued their participation with value so that it was important and relevant to their own perceptions of health, as well as personal and social well being.
Moreno-Black
Geraldine
G
Department of Anthropology, University of Oregon, Eugene, OR 97403, USA. gmorenob@oregon.uoregon.edu
Shor-Posner
Gail
G
Miguez
Maria-Jose
MJ
Burbano
Ximena
X
O'Mellan
Sandra
S
Yovanoff
P
P
D000328:Adult; D001294:Attitude to Health; D019587:Dietary Supplements; D005260:Female; D005431:Florida; D015658:HIV Infections / Q000188:drug therapy / Q000523:psychology*; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D035842:Research Subjects / Q000523:psychology*; D012643:Selenium / Q000627:therapeutic use; D012944:Social Support
D012643:Selenium