CEPH individuals are representative of the European American population: implications for pharmacogenetics.
Previous studies have highlighted the use of phenotype generation in immortalized lymphoblastoid cells from the Centre d'Etude du Polymorphisme Humain (CEPH) pedigrees as a powerful means of discovering genes involved in complex biological and pharmacological phenotypes. However, there is no data on how representative CEPH pedigrees are of the general population of European origin for genetic variants of pharmacogenetic significance. A vast amount of data in a population of restricted applicability would be of little value. Genotype and allele frequencies of 28 variants in 15 pharmacogenetically relevant genes were analyzed in germ-line DNA from European- and African-origin blood donors, and CEPH cell lines of European origin. The results demonstrate that allele frequencies for the 28 polymorphisms are highly similar between the CEPH and the European-origin populations. However, genotype frequencies in the CEPH population did not provide a high level of prediction for the African-origin population. These data support the usefulness of the CEPH panel in pharmacogenetic discovery efforts for European-derived populations.
Meucci
Melissa A
MA
Washington University School of Medicine, Department of Medicine, St. Louis, MO, USA.
Marsh
Sharon
S
Watters
James W
JW
McLeod
Howard L
HL
D044383:Black People / Q000235:genetics; D002461:Cell Line, Transformed; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D010375:Pedigree; D010597:Pharmacogenetics / Q000379:methods / Q000639:trends*; D044465:White People / Q000235:genetics*