title: The lectin-like oxidized low-density lipoprotein receptor and its role in atherosclerosis.
abstract: The lectin-like oxidized low-density lipoprotein receptor (LOX-1), a recently identified receptor that plays a role in the uptake of oxidized low-density lipoproteins into endothelial cells, has a pivotal role in the pathogenesis of atherosclerosis. The ways this receptor takes part in atherosclerosis is through uptake of oxidized low-density lipoproteins into endothelial cells, smooth muscle cells, and macrophages; decreasing nitric oxide production; increasing inflammatory cell recruitment; and increasing smooth muscle cell proliferation. LOX-1 is inducible and regulated by multiple factors known to underlie atherogenesis. Further understanding of this receptor may lead to potential molecular targets for prevention and treatment of atherosclerosis.
authors.affiliation: Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Cilingiroglu@uthscsa.edu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Cilingiroglu
authors.forename: Kerem
authors.initials: K
authors.lastname: Ozer
mesh_terms: D000818:Animals; D001158:Arteries / Q000378:metabolism / Q000473:pathology; D001161:Arteriosclerosis / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control; D015415:Biomarkers / Q000378:metabolism; D002478:Cells, Cultured; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011973:Receptors, LDL / Q000378:metabolism*; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E
chemical_list: D015415:Biomarkers; C495137:OLR1 protein, human; D012333:RNA, Messenger; D011973:Receptors, LDL; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E
references.citation: Biochim Biophys Acta. 1999 Jan 4;1436(3):279-98
references.pmid: 9989260
references.citation: Arterioscler Thromb Vasc Biol. 1998 Oct;18(10):1541-7
references.pmid: 9763524
references.citation: Circ Res. 1998 Aug 10;83(3):328-33
references.pmid: 9710126
references.citation: Biochem Biophys Res Commun. 2001 Jun 22;284(4):961-5
references.pmid: 11409887
references.citation: J Immunol. 2001 Apr 15;166(8):5108-14
references.pmid: 11290792
references.citation: Arterioscler Thromb Vasc Biol. 1996 Mar;16(3):416-24
references.pmid: 8630668
references.citation: Biochem Biophys Res Commun. 2001 Mar 23;282(1):180-5
references.pmid: 11263989
references.citation: Biochem Biophys Res Commun. 2000 Oct 22;277(2):368-80
references.pmid: 11032732
references.citation: Biochem Biophys Res Commun. 2001 Mar 2;281(3):720-5
references.pmid: 11237717
references.citation: Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):1860-72
references.pmid: 10938005
references.citation: Circulation. 2003 Feb 4;107(4):612-7
references.pmid: 12566375
references.citation: J Biol Chem. 2000 Mar 3;275(9):6573-9
references.pmid: 10692464
references.citation: Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9535-40
references.pmid: 9689115
references.citation: Trends Cardiovasc Med. 2001 Jan;11(1):22-5
references.pmid: 11413048
references.citation: Circulation. 2000 Jun 27;101(25):2889-95
references.pmid: 10869259
references.citation: Biochem Biophys Res Commun. 2001 Aug 24;286(3):541-6
references.pmid: 11511093
references.citation: Biochem Pharmacol. 1999 Feb 15;57(4):383-6
references.pmid: 9933026
references.citation: Circ Res. 1999 May 14;84(9):1043-9
references.pmid: 10325241
references.citation: Biochem Biophys Res Commun. 2001 Oct 5;287(4):962-8
references.pmid: 11573959
references.citation: Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):360-4
references.pmid: 10618423
references.citation: Biochem Biophys Res Commun. 1998 Jul 30;248(3):511-4
references.pmid: 9703956
references.citation: Biochem Biophys Res Commun. 1997 Aug 28;237(3):496-8
references.pmid: 9299391
references.citation: Biochem Biophys Res Commun. 2000 Jun 7;272(2):357-61
references.pmid: 10833418
references.citation: Arterioscler Thromb Vasc Biol. 2000 Apr;20(4):1107-15
references.pmid: 10764681
references.citation: J Cell Sci. 2001 Apr;114(Pt 7):1273-82
references.pmid: 11256994
references.citation: J Biol Chem. 2000 Apr 28;275(17):12633-8
references.pmid: 10777555
references.citation: Ann N Y Acad Sci. 2000 May;902:328-35
references.pmid: 10865858
references.citation: Biochem J. 1998 Aug 15;334 ( Pt 1):9-13
references.pmid: 9693095
references.citation: Circ Res. 1998 Aug 10;83(3):322-7
references.pmid: 9710125
references.citation: Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H782-90
references.pmid: 15016631
references.citation: J Am Coll Cardiol. 2002 May 1;39(9):1429-35
references.pmid: 11985903
references.citation: Biochem J. 2001 Apr 15;355(Pt 2):289-96
references.pmid: 11284714
references.citation: FASEB J. 2001 Apr;15(6):1095-7
references.pmid: 11292679
references.citation: J Mol Cell Cardiol. 1999 Dec;31(12):2101-14
references.pmid: 10640439
references.citation: J Biol Chem. 2001 Apr 27;276(17):13750-5
references.pmid: 11278710
references.citation: Nature. 1997 Mar 6;386(6620):73-7
references.pmid: 9052782
references.citation: Circulation. 1999 Aug 31;100(9):899-902
references.pmid: 10468518
references.citation: Biochem J. 1999 Apr 1;339 ( Pt 1):177-84
references.pmid: 10085242
references.citation: Genomics. 1998 Dec 1;54(2):191-9
references.pmid: 9828121
references.citation: FEBS Lett. 1998 Nov 27;440(1-2):29-32
references.pmid: 9862418
references.citation: Arterioscler Thromb Vasc Biol. 2000 Apr;20(4):1116-22
references.pmid: 10764682
references.citation: J Nutr. 2003 Nov;133(11):3588-91
references.pmid: 14608078
references.citation: FEBS Lett. 2001 Jun 22;499(3):215-9
references.pmid: 11423119