Potential oncogenic action of tenascin-C in tumorigenesis.
The prominent expression of tenascin-C in the stroma of most solid tumors, first observed in the mid 1980s, implicates tenascin-C in tumorigenesis. This is also supported by in vitro experiments that demonstrate the capacity of tenascin-C to stimulate tumor growth by various mechanisms including promotion of proliferation, escaping immuno-surveillance and positively influencing angiogenesis. However, tumorigenesis in tenascin-C knock-out mice is not significantly different from that observed in control animals. Perhaps this is not unexpected if one considers that tenascin-C may act as an oncogene. The potential role of tenascin-C in tumorigenesis through its oncogenic action on cellular signaling will be discussed in this review, including how tenascin-C mediated tumor cell detachment might affect genome stability.
Orend
Gertraud
G
Institute of Biochemistry and Genetics, Departement fiir Klinisch Biologische Wissenschaften (DKBW), Center for Biomedicine, University Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland. gertraud.orend@unibas.ch
D000818:Animals; D001943:Breast Neoplasms / Q000209:etiology; D002277:Carcinoma / Q000209:etiology; D002453:Cell Cycle; D003599:Cytoskeleton / Q000378:metabolism; D005260:Female; D005353:Fibronectins / Q000378:metabolism; D042822:Genomic Instability; D005910:Glioma / Q000209:etiology; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000209:etiology*; D011518:Proto-Oncogene Proteins / Q000494:pharmacology* / Q000502:physiology; D015398:Signal Transduction; D019063:Tenascin / Q000494:pharmacology* / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000378:metabolism
D005353:Fibronectins; D011518:Proto-Oncogene Proteins; D019063:Tenascin; D025521:Tumor Suppressor Proteins