[Screening of natural compounds with hypolipidemic activity].
In the screening programme for natural hypolipidemic compounds 702 strains of soil microorganisms were tested and 25 of them were selected because of their ability to produce compounds inhibiting sterol synthesis in Hep G2 hepatoma cells. The compounds were estimated in the microbiological model with Tolypocladium inflatum 106 as the test microbe. The 2nd stage of the screening resulted in isolation of 13 strains producing compounds with high hypolipidemic activity, analogous to or higher than the activity of lovastatin in the experimental models.
Chmel'
Ia V
IaV
Bibikova
M V
MV
Spiridonova
I A
IA
Tertov
V V
VV
Katlinskiĭ
A V
AV
D045744:Cell Line, Tumor; D017077:Culture Media, Conditioned / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004875:Ergosterol / Q000096:biosynthesis; D005051:Eubacterium / Q000302:isolation & purification / Q000378:metabolism; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D003904:Mitosporic Fungi / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D012988:Soil Microbiology; D013261:Sterols / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D013302:Streptomyces / Q000302:isolation & purification / Q000378:metabolism*
D017077:Culture Media, Conditioned; D000960:Hypolipidemic Agents; D013261:Sterols; D004875:Ergosterol