title: Spontaneous T wave alternans in a patient with Brugada syndrome--responses to intravenous administration of class I antiarrhythmic drug, glucose tolerance test, and atrial pacing.
abstract: Spontaneous T wave alternans in Brugada syndrome. A 43-year-old man with an episode of syncope showed ECG patterns of coved-type ST elevation in leads V1-V3 and right bundle branch block pattern. The patient had spontaneous T wave alternans at baseline, and T wave alternans diminished with distinct development of ST elevation after administration of Na+ channel blocker, and during oral glucose load and atrial pacing. Na+ channel mutation may contribute to the genesis of his ECG changes.
authors.affiliation: Department of Cardiology, Yokohama Minami Kyosai Hospital, Yokohama, Japan. nisizaki@yhb.att.ne.jp
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Nishizaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujii
authors.forename: Harumizu
authors.initials: H
authors.lastname: Sakurada
authors.forename: Akinori
authors.initials: A
authors.lastname: Kimura
authors.forename: Masayasu
authors.initials: M
authors.lastname: Hiraoka
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D002037:Bundle-Branch Block / Q000503:physiopathology* / Q000628:therapy*; D002304:Cardiac Pacing, Artificial; D016757:Death, Sudden, Cardiac; D004562:Electrocardiography; D005424:Flecainide / Q000627:therapeutic use; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D026941:Sodium Channel Blockers / Q000627:therapeutic use; D013577:Syndrome
chemical_list: D000889:Anti-Arrhythmia Agents; D026941:Sodium Channel Blockers; D005424:Flecainide