Oprelvekin-associated bilateral optic disk edema.
OBJECTIVE
To report a case of bilateral optic disk edema in a patient taking oprelvekin for radioimmunotherapy-induced thrombocytopenia.


METHODS
Observational case report.


METHODS
A 38-year-old man with a history of relapsed non-Hodgkins follicular lymphoma complained of bilateral loss of vision following oprelvekin therapy for thrombocytopenia.


RESULTS
Funduscopic examination demonstrated bilateral optic disk edema with exudates inferotemporal to the right nerve. The results of magnetic resonance imaging of the brain and orbits and lumbar puncture were normal. The disk edema resolved with discontinuation of oprelvekin therapy.


CONCLUSIONS
Oprelvekin therapy may be associated with bilateral optic disk edema. This has been shown to be reversible in a primate model.
Peterson
Daniel C
DC
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Inwards
David J
DJ
Younge
Brian R
BR
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D017370:Interleukin-11 / Q000009:adverse effects*; D008224:Lymphoma, Follicular / Q000532:radiotherapy; D008297:Male; D010211:Papilledema / Q000139:chemically induced*; D016499:Radioimmunotherapy / Q000009:adverse effects; D011994:Recombinant Proteins / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000188:drug therapy / Q000209:etiology
D000970:Antineoplastic Agents; D017370:Interleukin-11; D011994:Recombinant Proteins; C105308:oprelvekin