title: In vitro screening of some Strychnos species for antiplasmodial activity.
abstract: The antiplasmodial activity of crude extracts of 19 species of Strychnos (Loganiaceae) was assessed in vitro against a chloroquine-susceptible strain of Plasmodium falciparum. For each species, ethyl acetate (EtOAc) extracts were analysed and, for the most active species, methanolic (MeOH) extracts were also tested. Among them, Strychnos variabilis De Wild. seemed to be very promising (inhibitory concentration 50% (IC50) < 5 microg/ml) whereas two other species, Strychnos gossweileri Exell and Strychnos mellodora S. Moore, could be interesting (IC50 < 15 microg/ml) in further antimalarial studies.
authors.affiliation: University of Liège, Natural and Synthetic Drugs Research Center, Laboratory of Pharmacognosy, B36, Avenue de l'Hôpital 1, 4000 Liège, Belgium.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Philippe
authors.forename: Luc
authors.initials: L
authors.lastname: Angenot
authors.forename: Patrick
authors.initials: P
authors.lastname: De Mol
authors.forename: Eric
authors.initials: E
authors.lastname: Goffin
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Hayette
authors.forename: Monique
authors.initials: M
authors.lastname: Tits
authors.forename: Michel
authors.initials: M
authors.lastname: Frédérich
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000502:physiology; D031451:Strychnos
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts