title: Adenoid cystic carcinoma of the head and neck. Clinicopathological analysis of 23 patients and review of the literature.
abstract: Adenoid cystic carcinoma (ACC) is a rare epithelial tumor with a distinct natural history characterized by an indolent but persistent growth, late onset of distant metastases and eventual death of patients. Between 1991 and 2003, 23 patients with ACC were treated in our Department. Surgery with a curative intent followed by radiotherapy (RT) was applied in 22 patients. Complete resection was achieved in 72.73% of patients. Local recurrence occurred in 26% of patients. Positive margins emerged as the only statistically significant parameter (p < 0.0001) influencing the development of local recurrence. Distant metastasis (DM) occurred in 47.8% of patients. In 54.5% of the patients developing DM, this occurred between 5 and 10 years after the initial treatment. DM was influenced by perineural invasion (p = 0.04) and was disassociated from local control of the tumor. The mean overall survival of our patients was 70.58 months and the mean disease free survival 61.85 months. Perineural invasion (p = 0.048) and DM (p = 0.001) had a statistically significant impact on final patients' outcome. The most important factor influencing survival was DM. Its late onset, irrespectively of local control, supports the hypothesis that ACC has a potential to develop DM in the very early phases of tumor growth.
authors.affiliation: Department of Maxillofacial Surgery, Greek Anticancer Institute, St. Savvas Hospital, 171 Alexandras Avenue, Athens 115 22, Greece. rapidis@usa.net
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Rapidis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Givalos
authors.forename: Hariklia
authors.initials: H
authors.lastname: Gakiopoulou
authors.forename: Gregory
authors.initials: G
authors.lastname: Faratzis
authors.forename: Spyros D
authors.initials: SD
authors.lastname: Stavrianos
authors.forename: George A
authors.initials: GA
authors.lastname: Vilos
authors.forename: Emmanuel E
authors.initials: EE
authors.lastname: Douzinas
authors.forename: Efstratios
authors.initials: E
authors.lastname: Patsouris
mesh_terms: D000328:Adult; D003528:Carcinoma, Adenoid Cystic / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D015996:Survival Rate