Imminent approaches towards molecular interventions in ageing.
Ageing is an innate feature of living organisms. Sensational progress in its molecular understanding in the last decade has culminated into a highly complex picture. Emerging from this complexity are the distinctive roles of some of the tumor suppressor pathways including p53 and pRB in maintenance of senescence phenotype, and telomere maintaining pathways in its escape. We discuss here the current scenario of molecular ageing and the use of modern approaches for its intervention in culture system, at least. Many of the tools we describe here are the newly emergent functional RNA tools that are proved to be fruitful in decoding the human genome. These post-genomic technologies will help us in the discovery of gene targets for interventions aiming to improve the quality at later years of life beyond their mere algebraic extension.
Wadhwa
Renu
R
Gene Function Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba Science City 305-8562, Japan.
Deocaris
Custer C
CC
Widodo
Nashi
N
Taira
Kazunari
K
Kaul
Sunil C
SC
D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology*; D015316:Genetic Therapy; D015894:Genome, Human; D006801:Humans; D034622:RNA Interference; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53