title: [Carcinogenic effects of sterigmatocystin and deoxynivalenol in NIH mice].
abstract: OBJECTIVE
  To further explore the carcinogenic activity of Sterigmatocystin (ST) and the possible synergistic carcinogenic effect of deoxynivalenol (DON) in NIH mice.
  
  
  METHODS
  NIH mice were randomly divided into 6 groups, 30 in each. Five groups of mice were given by gastric intubation ST 3 microg/kg, ST 30 microg/kg, ST 3 microg/kg + DON 1.5 microg/kg, ST 30 microg/kg + DON 1.5 microg/kg and DON 1.5 microg/kg respectively, 3 times a week for 24 weeks. The remaining group of mice was given normal saline accordingly, serving as control. All mice were fed with HPLC-confirmed mycotoxin-free food, analysis. The mice were killed and pathologically examined at 58th and 74th weeks.
  
  
  RESULTS
  No pathological changes were found in the control group of mice. Adenocarcinoma of lung was observed in 25.0%, 41.7%, 62.5%, 69.2% and 37.5% of mice given ST 3 microg/kg, ST 30 microg/kg, ST 3 microg/kg + DON 1.5 microg/kg, ST 30 microg/kg + DON 1.5 microg/kg and DON 1.5 microg/kg, respectively. In addition, dysplasia of glandular stomach was detected in 50.0%, 58.3%, 37.5%, 53.8% and 25.0% of mice similarly treated.
  
  
  CONCLUSIONS
  Oral administration of ST or DON can induce adenocarcinoma in lung and dysplasia of glandular stomach in NIH mice. There is synergistic carcinogenic effect when both ST and DON are given.
authors.affiliation: Laboratory of Experimental Pathology, Hebei Medical University, Shijiazhuang, Hebei 050017, China.
authors.forename: Xiang-hua
authors.initials: XH
authors.lastname: Huang
authors.forename: Xiang-hong
authors.initials: XH
authors.lastname: Zhang
authors.forename: Yue-hong
authors.initials: YH
authors.lastname: Li
authors.forename: Jun-ling
authors.initials: JL
authors.lastname: Wang
authors.forename: Xia
authors.initials: X
authors.lastname: Yan
authors.forename: Ling-xiao
authors.initials: LX
authors.lastname: Xing
authors.forename: Feng-rong
authors.initials: FR
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000473:pathology; D013241:Sterigmatocystin / Q000633:toxicity*; D014255:Trichothecenes / Q000633:toxicity*
chemical_list: D014255:Trichothecenes; D013241:Sterigmatocystin; C007262:deoxynivalenol