title: Structural and functional characterization of polyphenols isolated from acerola (Malpighia emarginata DC.) fruit.
abstract: Two anthocyanins, cyanidin-3-alpha-O-rhamnoside (C3R) and pelargonidin-3-alpha-O-rhamnoside (P3R), and quercitrin (quercetin-3-alpha-O-rhamnoside), were isolated from acerola (Malpighia emarginata DC.) fruit. These polyphenols were evaluated based on the functional properties associated with diabetes mellitus or its complications, that is, on the radical scavenging activity and the inhibitory effect on both alpha-glucosidase and advanced glycation end product (AGE) formation. C3R and quercitrin revealed strong radical scavenging activity. While the inhibitory profiles of isolated polyphenols except quercitrin towards alpha-glucosidase activity were low, all polyphenols strongly inhibited AGE formation.
authors.affiliation: Research and Development Division, Processed Foods Company, Nichirei Corporation, Chiba, Japan. hanamurat@nichirei.co.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hanamura
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Hagiwara
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kawagishi
mesh_terms: D000872:Anthocyanins / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000302:isolation & purification; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors; D065089:Glycoside Hydrolase Inhibitors; D029581:Malpighiaceae / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology*; D059808:Polyphenols; D011794:Quercetin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D012210:Rhamnose / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D005419:Flavonoids; D017127:Glycation End Products, Advanced; D065089:Glycoside Hydrolase Inhibitors; D010636:Phenols; D059808:Polyphenols; C502042:cyanidin-3-O-rhamnoside; C502043:pelargonidin-3-O-rhamnoside; C012526:quercitrin; D011794:Quercetin; D012210:Rhamnose