title: Total synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B).
abstract: Starting from L-serine, a stereoselective synthesis of pachastrissamine, a structurally novel anhydrosphingosine derivative, is reported in this Letter. [structure: see text]
authors.affiliation: Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA.
authors.forename: Pushpal
authors.initials: P
authors.lastname: Bhaket
authors.forename: Kay
authors.initials: K
authors.lastname: Morris
authors.forename: Christina S
authors.initials: CS
authors.lastname: Stauffer
authors.forename: Apurba
authors.initials: A
authors.lastname: Datta
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D012694:Serine / Q000737:chemistry*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; C468594:pachastrissamine; D012694:Serine; D013110:Sphingosine