title: [Indications for bone marrow biopsy in adults].
abstract: Bone marrow biopsies are more and more often part of the work-up of patients with haematological disorders. The most important reason for this is the fact that a biopsy supplies important additional information compared to an aspirate alone. Biopsies are superior for the assessment of the bone marrow architecture, the vascularisation, the cellularity, the localisation and the extent of infiltrates and the degree of fibrosis. In addition, biopsy is a good way to evaluate the effects of therapy in the course of the disease. As is the case with aspirates, examination of a biopsy alone is usually sufficient for a correct diagnosis. However, a combination of both techniques makes possible an optimal assessment of the nature and extent of the disease process in the often very serious haematological conditions that we are dealing with here.
authors.affiliation: Universitair Medisch Centrum Utrecht, afd. Pathologie, Postbus 85.500, 3508 GA Utrecht.
authors.forename: A M W
authors.initials: AM
authors.lastname: van Marion
authors.forename: H M
authors.initials: HM
authors.lastname: Lokhorst
authors.forename: J G
authors.initials: JG
authors.lastname: van den Tweel
mesh_terms: D001707:Biopsy, Needle / Q000379:methods; D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination; D006402:Hematologic Diseases / Q000175:diagnosis* / Q000473:pathology; D006801:Humans