Facile and highly selective conversion of nitriles to amides via indirect acid-catalyzed hydration using TFA or AcOH-H2SO4.
Both aliphatic and aromatic nitriles are conveniently and selectively converted in a single step, via an indirect acid-catalyzed hydration, into the corresponding amides in 1-8 h using a TFA-H2SO4 mixture as a reagent system. Although the same reagent did not work for the sterically hindered nitriles such as mesitonitrile, the transformation could be accomplished by changing TFA to AcOH at higher temperatures (>90 degrees C).
Moorthy
Jarugu Narasimha
JN
Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, India. moorthy@iitk.ac.in
Singhal
Nidhi
N
D000085:Acetates / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D013464:Sulfuric Acids / Q000737:chemistry*; D014269:Trifluoroacetic Acid / Q000737:chemistry*
D000085:Acetates; D000577:Amides; D009570:Nitriles; D013464:Sulfuric Acids; D014269:Trifluoroacetic Acid