Intestinal complications in children undergoing chemotherapy for mediastinal non-Hodgkin's lymphoma.
Toxicities involving gastrointestinal tract are common in patients undergoing aggressive chemotherapy for cancer. However, it is uncommon to develop severe ulceration or perforation of the small intestine in absence of direct involvement of the bowel with the malignancy. The authors describe two children who developed severe gastrointestinal complications requiring surgical intervention following initial chemotherapy for non-Hodgkin's lymphoma. Both patients had no evidence of small bowel involvement by lymphoma on clinical staging.
Hata
Susan
S
Department of Pediatrics and Pediatric Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Pietsch
John
J
Shankar
Sadhna
S
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use / Q000633:toxicity*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000209:etiology; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000209:etiology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D014456:Ulcer / Q000139:chemically induced / Q000209:etiology