title: Association between reduced extraversion and right posterior fusiform gyrus gray matter reduction in chronic schizophrenia.
abstract: OBJECTIVE
  The authors examined the association between volume of the fusiform gyrus, a region involved in face processing, and the personality trait of extraversion in patients with schizophrenia.
  
  
  METHODS
  Male patients (N=24) and age-matched male comparison subjects (N=26) completed NEO Five-Factor Inventory personality measures of extraversion and underwent high-spatial-resolution magnetic resonance imaging of anterior and posterior fusiform gyrus gray matter.
  
  
  RESULTS
  Low extraversion scores were significantly correlated with gray matter volume reductions in the right posterior fusiform gyrus for patients but not comparison subjects.
  
  
  CONCLUSIONS
  Reduced right posterior fusiform gyrus volume may contribute to disease-related social disturbances, characterized by both low extraversion and reduced sensitivity to human faces.
authors.affiliation: Department of Psychiatry, Boston VA Healthcare System-Brockton Division, Harvard Medical School, 940 Belmont St., Brockton, MA 02301, USA.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Onitsuka
authors.forename: Paul G
authors.initials: PG
authors.lastname: Nestor
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Gurrera
authors.forename: Martha E
authors.initials: ME
authors.lastname: Shenton
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.forename: Melissa
authors.initials: M
authors.lastname: Frumin
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Niznikiewicz
authors.forename: Robert W
authors.initials: RW
authors.lastname: McCarley
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005120:Extraversion, Psychological; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D010555:Personality Inventory; D020238:Prosopagnosia / Q000175:diagnosis / Q000503:physiopathology; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012737:Sex Factors; D012938:Social Perception; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000503:physiopathology
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