Spontaneous T wave alternans in a patient with Brugada syndrome--responses to intravenous administration of class I antiarrhythmic drug, glucose tolerance test, and atrial pacing.
Spontaneous T wave alternans in Brugada syndrome. A 43-year-old man with an episode of syncope showed ECG patterns of coved-type ST elevation in leads V1-V3 and right bundle branch block pattern. The patient had spontaneous T wave alternans at baseline, and T wave alternans diminished with distinct development of ST elevation after administration of Na+ channel blocker, and during oral glucose load and atrial pacing. Na+ channel mutation may contribute to the genesis of his ECG changes.
Nishizaki
Mitsuhiro
M
Department of Cardiology, Yokohama Minami Kyosai Hospital, Yokohama, Japan. nisizaki@yhb.att.ne.jp
Fujii
Hiroyuki
H
Sakurada
Harumizu
H
Kimura
Akinori
A
Hiraoka
Masayasu
M
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D002037:Bundle-Branch Block / Q000503:physiopathology* / Q000628:therapy*; D002304:Cardiac Pacing, Artificial; D016757:Death, Sudden, Cardiac; D004562:Electrocardiography; D005424:Flecainide / Q000627:therapeutic use; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D026941:Sodium Channel Blockers / Q000627:therapeutic use; D013577:Syndrome
D000889:Anti-Arrhythmia Agents; D026941:Sodium Channel Blockers; D005424:Flecainide