Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.
Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out.
Vanitallie
T B
TB
Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, St. Luke's-Roosevelt Hospital Center, New York, USA. tedvani@ewol.com
Nonas
C
C
Di Rocco
A
A
Boyar
K
K
Hyams
K
K
Heymsfield
S B
SB
D020155:3-Hydroxybutyric Acid / Q000378:metabolism*; D000090:Acetoacetates / Q000378:metabolism*; D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D003131:Combined Modality Therapy; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects / Q000145:classification / Q000627:therapeutic use*; D004044:Dietary Proteins / Q000008:administration & dosage; D042967:Electron Transport Complex I / Q000378:metabolism*; D004734:Energy Metabolism; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology / Q000517:prevention & control; D007659:Ketones / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010045:Outpatients; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000178:diet therapy* / Q000188:drug therapy / Q000378:metabolism; D010349:Patient Compliance; D016896:Treatment Outcome; D015431:Weight Loss
D000090:Acetoacetates; D000978:Antiparkinson Agents; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D007659:Ketones; C016635:acetoacetic acid; D002784:Cholesterol; D042967:Electron Transport Complex I; D020155:3-Hydroxybutyric Acid