Understanding protein folding through peptide models.
From the time it was recognized that proteins are made up primarily of secondary structures, theories of protein folding have used secondary structural elements as important building blocks. Peptides have played a central role in elucidating the factors that stabilize individual elements of secondary structure and are now being employed to study higher levels of organization. The control of conformation in peptides has taken on new relevance with the realization that protein folding plays a central role in many disease states.
Osterhout
John J
JJ
Department of Biochemistry and Molecular Biophysics, BSW 262, P. O. Box 21008, University of Arizona, Tucson, Arizona 85721, USA. johno@email.arizona.edu
D000818:Animals; D008956:Models, Chemical; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D017510:Protein Folding; D013997:Time Factors
D010455:Peptides