title: Human papilloma virus in oral squamous cell carcinoma in a Mexican population.
abstract: OBJECTIVE
  To determine the human papilloma virus (HPV) infection in oral cancer and its association with smoking and drinking habits.
  
  
  METHODS
  A cross-sectional study was performed; samples were collected from 51 patients with histological diagnosis of squamous-cell carcinoma were collected at the Instituto Nacional de Cancerología in Mexico City. HPV infection was detected by polymerase chain reaction, and the clinical characteristics of this population were analyzed.
  
  
  RESULTS
  Fifty samples out of 51 were positive for beta-globin; 21 (42%) cases were HPV-positive, and 14/21 were positive for HPV-16. We found more samples positive in men than in women (71% vs 29%). No differences were observed between HPV-positive and -negative patients in relation to smoking and drinking habits (81% vs 79%).
  
  
  CONCLUSIONS
  HPV infection was present in 42% of patients with oral squamous-cell carcinoma (OSCC); HPV-16 was the most frequent type, identified in 66.6%. Other cofactors participate in the development of OSCC, independent of HPV infection.
authors.affiliation: Instituto Nacional de Cancerología, Mexico City, Mexico. ibieta2000@hotmail.com
authors.forename: Blanca R
authors.initials: BR
authors.lastname: Ibieta
authors.forename: Marcela
authors.initials: M
authors.lastname: Lizano
authors.forename: Mauricio
authors.initials: M
authors.lastname: Fras-Mendivil
authors.forename: José L
authors.initials: JL
authors.lastname: Barrera
authors.forename: Adela
authors.initials: A
authors.lastname: Carrillo
authors.forename: Luz
authors.initials: L
authors.lastname: Ma Ruz-Godoy
authors.forename: Alejandro
authors.initials: A
authors.lastname: Mohar
mesh_terms: D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D003430:Cross-Sectional Studies; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification / Q000472:pathogenicity*; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking
chemical_list: D015344:DNA Probes, HPV; D004279:DNA, Viral