title: Synthesis and conformational study of 2-trityloxymethyltetrahydrofurans as key intermediates for antiviral nucleosides.
abstract: We wanted to elucidate the reason why the trityloxymethyl substituent in gamma-trityloxymethyl-gamma-butyrolactone takes a sterically unfavorable specific conformation, and so we synthesized 5-trityloxymethyldihydrofuran-3-one, 3-(trityloxymethyl)-4-butanolide and 2-trityloxymethyl-tetrahydrofuran and we then analyzed their conformation by 1H-NMR analysis.
authors.affiliation: College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea.
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Choi
authors.forename: Hee-Doo
authors.initials: HD
authors.lastname: Kim
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000378:metabolism; D005663:Furans / Q000138:chemical synthesis* / Q000378:metabolism; D008968:Molecular Conformation; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000378:metabolism; D014320:Triphenylmethyl Compounds / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D005663:Furans; D011741:Pyrimidine Nucleosides; D014320:Triphenylmethyl Compounds