title: Acyclic nucleosides bearing a furanyl scaffold.
abstract: Synthesis of acyclic nucleosides bearing a furanyl scaffold is described. The approach involved the construction of the base moiety onto a dihydrofuranyl intermediate. While the A and C analogues did exhibit some substrate activity toward deoxycytidine kinase, the compounds were devoid of any significant anti-HIV activity.
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Athens, GA 30602, USA. vnair@rx.uga.edu
authors.forename: Vasu
authors.initials: V
authors.lastname: Nair
authors.forename: Sanjib
authors.initials: S
authors.lastname: Bera
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D005663:Furans / Q000737:chemistry*; D006678:HIV; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry*; D013601:T-Lymphocytes / Q000378:metabolism / Q000821:virology
chemical_list: D000998:Antiviral Agents; D005663:Furans; D009705:Nucleosides