title: Immunohistochemical detection of [corrected] TrkB in the enteric nervous system of the small intestine in pigeon (Columba livia).
abstract: The presence and cell localization of TrkB, the main receptor for the neurotrophins (NTs), was investigated immunohistochemically in the small intestine of adult pigeons, with special reference to the enteric nervous system (ENS). Several neuronal (neurofilament proteins and PGP 9.5) and glial cell (S100 protein) markers were studied in parallel. TrkB immunoreactivity (TrkB-IR) was found to be restricted to immunohistochemically-identified glial cells present in the enteric plexuses, and to Schwann cells forming the perivascular plexus. Also, TrkB-IR was detected in enterochromaffin cells and in unidentified dendritic cells within the gut-associated lymphoid tissue. The present results demonstrate that as for mammals, TrkB in the ENS is restricted to the glial cells. The possible function of the TrkB ligands, however, remains to be established.
authors.affiliation: Dipartimento di Morfologia, Biochimica, Fisiologia e Produzioni Animali, Sezione di Morfologia, Università di Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Germanà
authors.forename: M B
authors.initials: MB
authors.lastname: Levanti
authors.forename: D F
authors.initials: DF
authors.lastname: Monjil
authors.forename: E
authors.initials: E
authors.lastname: Ciriaco
authors.forename: M
authors.initials: M
authors.lastname: Del Valle
authors.forename: J A
authors.initials: JA
authors.lastname: Vega
authors.forename: G
authors.initials: G
authors.lastname: Germanà
mesh_terms: D000818:Animals; D010856:Columbidae / Q000378:metabolism*; D017615:Enteric Nervous System / Q000737:chemistry*; D007150:Immunohistochemistry; D007421:Intestine, Small / Q000294:innervation*; D008297:Male; D009457:Neuroglia / Q000737:chemistry; D020813:Receptor, trkB / Q000032:analysis*
chemical_list: D020813:Receptor, trkB