title: Selection of a rare resistance profile in an HIV-1-infected patient exhibiting a failure to an antiretroviral regimen including tenofovir DF.
abstract: The human immunodeficiency virus type 1 (HIV-1) resistance profile, K65R, K70E and M184V, on reverse transcriptase gene was associated with the virologic rebound consecutively to the switch of lopinavir/r to tenofovir DF in a stable regimen with nucleoside backbone of abacavir, lamivudine and didanosine. The high selective pressure on the same resistance pathway was probably associated with the loss of antiviral potency, even in well-controlled patient.
authors.affiliation: Department of Virology, Necker-Enfants Malades Hospital, 149 rue de Sèvres, 75015 Paris, France. constance.delaugerre@nck.ap-hop-paris.fr
authors.forename: Constance
authors.initials: C
authors.lastname: Delaugerre
authors.forename: Laurent
authors.initials: L
authors.lastname: Roudiere
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.forename: Christine
authors.initials: C
authors.lastname: Rouzioux
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Viard
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Chaix
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D016049:Didanosine / Q000627:therapeutic use; D015224:Dideoxynucleosides / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000235:genetics; D005260:Female; D005681:Gabon; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D061466:Lopinavir; D008826:Microbial Sensitivity Tests; D009154:Mutation; D063065:Organophosphonates / Q000627:therapeutic use*; D011744:Pyrimidinones / Q000627:therapeutic use; D000068698:Tenofovir; D019562:Viral Load; D000099227:Abacavir
chemical_list: D000225:Adenine; D019380:Anti-HIV Agents; D016049:Didanosine; D015224:Dideoxynucleosides; D054303:HIV Reverse Transcriptase; D019259:Lamivudine; D061466:Lopinavir; D063065:Organophosphonates; D011744:Pyrimidinones; D000068698:Tenofovir; D000099227:Abacavir