title: Immunotherapy for human cancer using heat shock protein-peptide complexes.
abstract: Heat shock proteins (HSPs) are primordial and abundant molecules expressed in all cells. Publications starting in 1984 have shown that immunization of mice, rats, and frogs with purified preparations of selected HSPs isolated from cancers leads to protective immunity against the cancer used as the source of the HSP. The basis of the tumor-specific immunogenicity of these molecules lies not in the molecules themselves but in the array of peptides, including antigenic peptides chaperoned by them. These experiments and the ideas derived from them form the basis of an approach to immunotherapy for human cancer that began in 1995 and is now in full swing.
authors.affiliation: Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT 06030-1601, USA. srivastava@nso2.uchc.edu
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Srivastava
mesh_terms: D002986:Clinical Trials as Topic; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007114:Immunization; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D010446:Peptide Fragments / Q000276:immunology*
chemical_list: D006360:Heat-Shock Proteins; D010446:Peptide Fragments
references.citation: Immunogenetics. 1994;39(2):93-8
references.pmid: 8276462
references.citation: Science. 1996 Jun 14;272(5268):1606-14
references.pmid: 8658133
references.citation: J Immunol. 2004 May 1;172(9):5277-86
references.pmid: 15100266
references.citation: J Immunol. 2004 May 15;172(10):6087-92
references.pmid: 15128793
references.citation: Nat Immunol. 2000 Aug;1(2):151-5
references.pmid: 11248808
references.citation: Immunity. 2004 Jan;20(1):95-106
references.pmid: 14738768
references.citation: J Immunol. 2004 Aug 1;173(3):1987-93
references.pmid: 15265933
references.citation: J Immunol. 2004 Oct 15;173(8):5130-7
references.pmid: 15470057
references.citation: Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6128-33
references.pmid: 15073331
references.citation: J Cell Biol. 2003 Jun 23;161(6):1179-89
references.pmid: 12821648
references.citation: Cancer Res. 2004 Feb 15;64(4):1502-8
references.pmid: 14973071
references.citation: Tissue Antigens. 2004 Oct;64(4):442-51
references.pmid: 15361121
references.citation: Int J Cancer. 2003 Jun 10;105(2):226-31
references.pmid: 12673684
references.citation: J Clin Oncol. 2002 Oct 15;20(20):4169-80
references.pmid: 12377960
references.citation: J Biol Chem. 2004 Dec 3;279(49):51250-7
references.pmid: 15371419
references.citation: EMBO J. 2003 Nov 17;22(22):6127-36
references.pmid: 14609958
references.citation: J Biol Chem. 2004 Apr 16;279(16):16543-52
references.pmid: 14754890
references.citation: Blood. 2003 Sep 1;102(5):1806-14
references.pmid: 12750160
references.citation: J Virol. 2002 Jan;76(1):136-41
references.pmid: 11739679
references.citation: Immunity. 2001 Mar;14(3):303-13
references.pmid: 11290339
references.citation: Blood. 2003 May 15;101(10):4000-4
references.pmid: 12531796
references.citation: Cancer Immun. 2004 Apr 16;4:3
references.pmid: 15086273
references.citation: Cell. 1993 Nov 19;75(4):717-28
references.pmid: 7902213
references.citation: J Immunol. 2003 Oct 15;171(8):4054-61
references.pmid: 14530326
references.citation: Clin Cancer Res. 2003 Aug 15;9(9):3235-45
references.pmid: 12960108
references.citation: Cancer Immunol Immunother. 2003 Apr;52(4):226-34
references.pmid: 12669247
references.citation: Exp Cell Res. 2004 Jul 1;297(1):108-17
references.pmid: 15194429
references.citation: Cancer Res. 2001 Jan 1;61(1):222-7
references.pmid: 11196165
references.citation: Int Immunol. 2004 Apr;16(4):597-605
references.pmid: 15039390
references.citation: J Immunol. 2004 Mar 15;172(6):3719-24
references.pmid: 15004176
references.citation: J Exp Med. 2002 Dec 2;196(11):1447-59
references.pmid: 12461080
references.citation: J Immunol. 2002 Nov 15;169(10):5424-32
references.pmid: 12421917
references.citation: J Immunol. 1999 Nov 15;163(10):5178-82
references.pmid: 10553037
references.citation: Blood. 2003 Apr 1;101(7):2810-5
references.pmid: 12446445
references.citation: J Immunol. 2003 Oct 1;171(7):3467-74
references.pmid: 14500642
references.citation: Annu Rev Immunol. 2002;20:395-425
references.pmid: 11861608