[Actinic apparatus of phagocytes is a target for pathogenic bacteria].
The interaction between pathogenic microorganisms and eukaryotic cells is a topical area of research in microbiology and molecular medicine. This problem has been the subject of much study both in this country and abroad since early nineties; legionella, listeria, clostridium and other bacteria pathogenic to man have been used as model organisms. The results of the authors' research and literature data analysis underlie the hypothesis of the important role of bacterial enzymes, which modify components of eukaryotic cell actinic apparatus, in the virulence of infectious pathogens. Change in the activity of actinic cytoskeleton under the influence of microbe products has been demonstrated to be an effective mechanism, promoting bacterial proliferation in human organs and tissues. Here actinic apparatus components acts as a target for both "intracellular" and "extracellular" pathogens.
D000199:Actins / Q000502:physiology*; D000818:Animals; D001419:Bacteria / Q000378:metabolism / Q000472:pathogenicity* / Q000648:ultrastructure; D001424:Bacterial Infections / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D003599:Cytoskeleton / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D010587:Phagocytosis / Q000502:physiology
D000199:Actins