title: Gradual changes in the apparent diffusion coefficient of water in selectively vulnerable brain regions following brief ischemia in the gerbil.
abstract: Although selective vulnerability and delayed neuronal death following global ischemia have been recognized in both the human and animal brain, the underlying mechanisms of cell damage are not fully understood. In this study we investigated the time-dependent changes of the apparent diffusion coefficient (ADC) of water and cerebral blood flow (CBF) in a classic animal model of selective vulnerability and delayed neuronal death, using magnetic resonance (MR) diffusion- and perfusion-weighted imaging. CBF was monitored using the noninvasive MR arterial spin labeling method called flow-sensitive alternating inversion recovery (FAIR). Bilateral common carotid occlusion was induced for 5 min, followed by 10 hr of reperfusion in a gerbil model. The most notable finding was that the lateral portion of the striatum in the basal ganglia exhibited a prolonged and gradual ADC decrease throughout the study following reperfusion. This pattern was not exhibited within the cortex. It is suggested that regions known to exhibit so-called delayed cell death progress to infarction via a gradual process that can be monitored by MR diffusion-weighted imaging (DWI).
authors.affiliation: RCS Unit of Biophysics, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK. mlythgoe@ich.ucl.ac.uk
authors.forename: Mark F
authors.initials: MF
authors.lastname: Lythgoe
authors.forename: David L
authors.initials: DL
authors.lastname: Thomas
authors.forename: Martin D
authors.initials: MD
authors.lastname: King
authors.forename: Gaby S
authors.initials: GS
authors.lastname: Pell
authors.forename: Louise
authors.initials: L
authors.lastname: van der Weerd
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Ordidge
authors.forename: David G
authors.initials: DG
authors.lastname: Gadian
mesh_terms: D000818:Animals; D001834:Body Water / Q000378:metabolism*; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D002545:Brain Ischemia / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging; D005849:Gerbillinae; D007091:Image Processing, Computer-Assisted; D012039:Regional Blood Flow; D012044:Regression Analysis