Rapid and efficient synthesis of 1,2,4-oxadiazoles utilizing polymer-supported reagents under microwave heating.
1,2,4-Oxadiazoles can be rapidly and efficiently synthesized from a variety of readily available carboxylic acids and amidoximes using either method A or method B. The use of commercially available polymer-supported reagents combined with microwave heating resulted in high yields and purities of the product 1,2,4-oxadiazoles in an expeditious manner. [structure: see text]
Wang
Ying
Y
High-Throughput Organic Synthesis Group, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6113, USA. wang.ying@abbott.com
Miller
Reagan L
RL
Sauer
Daryl R
DR
Djuric
Stevan W
SW
D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D007202:Indicators and Reagents; D008872:Microwaves; D015394:Molecular Structure; D010069:Oxadiazoles / Q000032:analysis / Q000138:chemical synthesis*; D010091:Oximes / Q000737:chemistry*
D002264:Carboxylic Acids; D007202:Indicators and Reagents; D010069:Oxadiazoles; D010091:Oximes