title: Consumption of a high calcium mineral water lowers biochemical indices of bone remodeling in postmenopausal women with low calcium intake.
abstract: Many postmenopausal women have a calcium intake far below the recommended amount and, in addition to attempting to improve their diet, need a calcium supplement. The aim of the study was to assess the effects of the consumption of a high calcium mineral water (HCaMW) on biochemical indices of bone remodeling in postmenopausal women with low Ca intake. A 6-month randomized double-blind placebo-controlled trial was designed to assess the effects of a daily consumption of 1 liter of a HCaMW (596 mg Ca/l) on serum parathyroid hormone (PTH) and biochemical markers of bone remodeling in postmenopausal women with a dietary Ca intake lower than 700 mg/day. The placebo group drank 1 liter of a mineral water with a low calcium content (10 mg/l). One hundred eighty healthy women were recruited (mean age: 70.1+/-4.0 years); 152 completed the 6-month trial. The changes from baseline of biochemical indices after 6 months consisted of a significant 14.1% decrease of serum PTH, osteocalcin (-8.6%), bone alkaline phosphatase (-11.5%), serum (-16.3%) and urine (-13.0%) type-1 collagen C-telopeptide in the HCaMW group compared to the placebo group, where all biochemical indices increased after 6 months. The additive effect of a small vitamin D supplement (400 iu/day) was also evaluated. In women receiving vitamin D in addition to HCaMW, the decrease in bone indices was not found to be greater than in women drinking only the HCaMW. A daily supplement of 596 mg of Ca through the consumption of 1 l of HCaMW was able to lower serum PTH and the indices of bone turnover in postmenopausal women with a low Ca intake. This could contribute to the repair of calcium deficiency and to the reduction of age-related bone loss in this population.
authors.affiliation: Faculty of Medicine RTH, Laennec INSERM Unit 403, rue G. Paradin, 69372 Lyon Cedex 08, France. pierre.meunier@sante.univ-lyon1.fr
authors.forename: Pierre J
authors.initials: PJ
authors.lastname: Meunier
authors.forename: Cecile
authors.initials: C
authors.lastname: Jenvrin
authors.forename: Françoise
authors.initials: F
authors.lastname: Munoz
authors.forename: Viviane
authors.initials: V
authors.lastname: de la Gueronnière
authors.forename: Patrick
authors.initials: P
authors.lastname: Garnero
authors.forename: Michèle
authors.initials: M
authors.lastname: Menz
mesh_terms: D000368:Aged; D000886:Anthropometry; D015415:Biomarkers / Q000378:metabolism; D016723:Bone Remodeling / Q000187:drug effects*; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008900:Mineral Waters / Q000032:analysis*; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D010281:Parathyroid Hormone / Q000031:analogs & derivatives / Q000097:blood; D017698:Postmenopause / Q000502:physiology*; D014807:Vitamin D / Q000008:administration & dosage
chemical_list: D015415:Biomarkers; D002136:Calcium, Dietary; D008900:Mineral Waters; C470125:PTH protein, human; D010281:Parathyroid Hormone; D014807:Vitamin D
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