title: Impact of obesity on 24-hour ambulatory blood pressure and hypertension.
abstract: The purpose of the present study was to determine the relationship between body mass index (BMI) and parameters derived from 24-hour ambulatory blood pressure monitoring including mean 24-hour daytime and nighttime systolic and diastolic blood pressures, 24-hour daytime and nighttime pulse pressure, mean 24-hour daytime and nighttime heart rate, dipping and nondipping status. 3216 outpatient subjects who visited our hypertension center and were never treated with antihypertensive medication underwent 24-hour blood pressure monitoring. BMI was significantly correlated with clinic systolic and diastolic blood pressures. Significant correlations were also found between BMI and mean 24-hour daytime and nighttime systolic blood pressure, 24-hour daytime and nighttime pulse pressure, and mean 24-hour daytime and nighttime heart rate. In multivariate regression analysis, clinic systolic, diastolic blood pressure, mean 24-hour systolic blood pressure, 24-hour pulse pressure, and high-density lipoprotein were independently correlated with BMI. The incidence of white coat hypertension was higher in overweight and obese patients than in normal weight subjects. Confirmed ambulatory blood pressure hypertension was also found to be higher in overweight and obese individuals compared with normal weight subjects. Our data also highlight the higher incidence of nondipping status in obesity. These findings suggest that obese patients had increased ambulatory blood pressure parameters and altered circadian blood pressure rhythm with increased prevalence of nondipping status.
authors.affiliation: Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodestrial University, Athens, Greece. vkotsis@physiology.umsmed.edu
authors.forename: Vasilios
authors.initials: V
authors.lastname: Kotsis
authors.forename: Stella
authors.initials: S
authors.lastname: Stabouli
authors.forename: Marshall
authors.initials: M
authors.lastname: Bouldin
authors.forename: Annette
authors.initials: A
authors.lastname: Low
authors.forename: Savvas
authors.initials: S
authors.lastname: Toumanidis
authors.forename: Nikos
authors.initials: N
authors.lastname: Zakopoulos
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D002940:Circadian Rhythm; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology*
chemical_list: D008075:Lipoproteins, HDL