title: A complex translocation (9;22;16)(q34;q11.2;p13) in chronic myelocytic leukemia.
abstract: The t(9;22) is present in almost all cases with chronic myelocytic leukemia (CML). Around 5% of these patients show complex translocations involving a third chromosome in addition to chromosomes 9 and 22. All chromosomes have participated in these variants and the BCR-ABL1 hybrid gene is always present. We describe a CML case with a new complex t(9;22;16)(q34;q11.2;p13). Seven months after imatinib treatment a karyotype showed the appearance of a clone with a standard t(9;22) in addition to the clone with the complex translocation. The b3a2 transcript of BCR-ABL1 was detected both at diagnosis and 7 months after therapy. In CML, both complex translocations and standard translocations have the same prognosis. However, these complex variants could contribute to the tumoral evolution by conferring selective advantages that, in turn, cause the preferential manifestation at diagnosis of clones with complex translocations.
authors.affiliation: Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: Juan Pablo Meza
authors.initials: JP
authors.lastname: Espinoza
authors.forename: Verónica Judith Picos
authors.initials: VJ
authors.lastname: Cárdenas
authors.forename: Erika Alejandra Vásquez
authors.initials: EA
authors.lastname: Jiménez
authors.forename: Melva Gutiérrez
authors.initials: MG
authors.lastname: Angulo
authors.forename: María Amparo Esparza
authors.initials: MA
authors.lastname: Flores
authors.forename: Juan Ramón González
authors.initials: JR
authors.lastname: García
mesh_terms: D002675:Child, Preschool; D002871:Chromosome Banding; D002885:Chromosomes, Human, Pair 16; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic
chemical_list: D016044:Fusion Proteins, bcr-abl