title: Molecular recognition of trigonal oxyanions using a ditopic salt receptor: evidence for anisotropic shielding surface around nitrate anion.
abstract: A ditopic, macrobicyclic receptor with adjacent anion and cation binding sites is able to extract a range of monovalent salts into chloroform solution. The structures of the receptor complexed with KAcO, LiNO(3), NaNO(3), KNO(3), and NaNO(2) are characterized in solution by NMR spectroscopy and in the solid state by X-ray crystallography. The sodium and potassium salts are bound to the receptor as contact ion-pairs, with the metal cation located in the receptor's crown ether ring and the trigonal oxyanion hydrogen bonded to the receptor NH residues. The solid-state structure of the LiNO(3) complex has a bridging water molecule between the cation and anion. In all solid-state structures, the trigonal oxyanion is not located symmetrically inside the receptor cavity. It appears that anion orientation is controlled by a complex interplay of steric factors, coordination bonding to the metal cation, and hydrogen bonding with the receptor NH residues. An important feature with this latter effect is the fact that hydrogen bonds directed toward the oxygen lone pairs on a trigonal oxyanion are stronger than hydrogen bonds to the pi-electrons. In solution, the (1)H NMR spectra of the nitrate and nitrite salt complexes are noteworthy because several receptor signals, including the NH protons, undergo unusual upfield movements in chemical shift upon complexation. This is a reflection of the diamagnetic anisotropy of these trigonal oxyanions. The magnetic shielding surface for the NO(3)(-) anion is calculated using density functional theory and shown to have a shielding region directly above the central nitrogen.
authors.affiliation: Department of Chemistry and Biochemistry, and Radiation Laboratory, University of Notre Dame, Notre Dame, Indiana 46556-5670, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Mahoney
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Stucker
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Ian
authors.initials: I
authors.lastname: Carmichael
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Brinkmann
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Beatty
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Noll
authors.forename: Bradley D
authors.initials: BD
authors.lastname: Smith