title: A case of double cancer involving oral malignant melanoma and gastrointestinal stromal tumor (GIST).
abstract: We report a very rare case of double cancer involving palatal malignant melanoma and gastrointestinal stromal tumor (GIST), a rare tumor of the gastrointestinal tract originating from a primitive mesenchymal cell. After chemotherapy, radiation therapy, and treatment with interferon and OK-432, the GIST was resected and the melanoma disappeared. The patient has had no evidence of recurrent tumor, and the patient's clinical course has been uneventful for 1 year. This is probably the first report of synchronous double cancer involving oral malignant melanoma and GIST.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Mie University, Tsu, Mie 514-8507, Japan. knagai@mocha.ocn.ne.jp
authors.forename: K
authors.initials: K
authors.lastname: Nagai
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumura
authors.forename: J
authors.initials: J
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Inui
authors.forename: T
authors.initials: T
authors.lastname: Tagawa
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology* / Q000601:surgery; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000628:therapy; D010157:Palatal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D010844:Picibanil / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D010844:Picibanil; D016899:Interferon-beta