Effects of clomipramine on self-control choice in Lewis and Fischer 344 rats.
Rates of delay discounting (impulsive choice) have been shown to vary among individuals, particularly people who abuse drugs relative to those who do not, but factors that may contribute to these differences have not been identified. To explore a role for possible genetic and neurochemical determinants, Lewis (n = 8) and Fischer 344 (n = 8) rats were allowed to choose between one food pellet delivered immediately and three food pellets delivered after increasing delays. The delays to the large reinforcer (0, 10, 20, 40, 60 s) were increased across five blocks of trials in daily experimental sessions. For both groups of rats, choice for the larger reinforcer decreased as the delay to presentation increased. However, the Lewis rats were more likely to choose the smaller, immediate reinforcer earlier in the session, i.e., at shorter large-reinforcer delays, than the Fisher 344 rats. This difference in choice was statistically significant. Repeated administration of 3.0 mg/kg, i.p. clomipramine (mean of last five sessions) did not significantly alter choice, relative to baseline, for either strain. The present findings suggest that differences in delay discounting/impulsive choice may involve genetic, e.g., neurochemical, differences.
Anderson
Karen G
KG
University of Mississippi Medical Center, Jackson, MS, USA. Karen.Anderson@mail.wvu.edu
Woolverton
William L
WL
D000818:Animals; D002755:Choice Behavior / Q000187:drug effects* / Q000502:physiology; D002997:Clomipramine / Q000494:pharmacology*; D007175:Impulsive Behavior / Q000523:psychology; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D012055:Reinforcement Schedule
D002997:Clomipramine
Psychopharmacology (Berl). 1999 Oct;146(4):422-31
10550492
Psychopharmacology (Berl). 1998 Dec;140(3):319-30
9877012
Ann N Y Acad Sci. 1997 Dec 29;836:158-81
9616798
Behav Pharmacol. 1996 Aug;7(4):395-399
11224433
Exp Clin Psychopharmacol. 1998 Aug;6(3):292-305
9725113
Psychopharmacology (Berl). 2001 Mar;154(3):243-50
11351931
Psychopharmacology (Berl). 1999 Oct;146(4):413-21
10550491
Brain Res. 1999 Jun 19;832(1-2):152-8
10375661
Brain Res. 1998 Dec 14;814(1-2):34-40
9838033
Behav Brain Res. 1996;73(1-2):365-68
8788533
J Exp Anal Behav. 1998 Nov;70(3):253-65
9821679
Psychopharmacology (Berl). 1992;109(1-2):245-7
1365666
Neurochem Res. 2001 Jun;26(6):609-17
11519721
Psychopharmacology (Berl). 1999 Oct;146(4):348-61
10550486
Behav Sci Law. 2000;18(5):581-604
11113963
Exp Clin Psychopharmacol. 1997 Aug;5(3):256-62
9260073
Neuropsychopharmacology. 2000 Jan;22(1):64-76
10633492
J Pharmacol Exp Ther. 1988 Apr;245(1):164-70
3258911
Behav Pharmacol. 1995 Dec;6(8):810-814
11224384
Jpn J Pharmacol. 1988 Aug;47(4):425-31
3263529
Brain Res. 1996 Apr 15;716(1-2):157-64
8738232
Psychopharmacology (Berl). 1996 Nov;128(2):161-70
8956377
Psychopharmacology (Berl). 2000 May;150(1):90-101
10867981
Synapse. 1997 May;26(1):93-4
9097409
J Exp Anal Behav. 1995 Nov;64(3):263-76
16812772
Psychopharmacology (Berl). 2000 Nov;152(4):390-7
11140331
Psychopharmacology (Berl). 2000 Nov;152(4):362-75
11140328
Brain Res. 1997 Dec 19;778(2):418-29
9459563
Psychopharmacology (Berl). 1999 Oct;146(4):339-47
10550485
Psychopharmacology (Berl). 1999 Oct;146(4):447-54
10550495
Psychon Bull Rev. 1994 Sep;1(3):383-9
24203522
Behav Brain Res. 2002 Nov 15;136(2):349-57
12429396
Science. 2001 Jun 29;292(5526):2499-501
11375482
J Exp Anal Behav. 1972 Jan;17(1):15-22
16811561
Drug Alcohol Depend. 1999 Aug 2;56(1):25-32
10462089
Psychopharmacology (Berl). 1999 Oct;146(4):473-81
10550498
J Pharmacol Exp Ther. 1994 Apr;269(1):137-44
8169817
J Exp Anal Behav. 1974 May;21(3):485-9
16811760
Biol Psychiatry. 1997 Mar 1;41(5):523-9
9046984
Psychopharmacology (Berl). 1999 Oct;146(4):362-72
10550487
Behav Processes. 2004 Jun 30;66(3):213-33
15157974
Alcohol Clin Exp Res. 1984 Sep-Oct;8(5):485-6
6391261
Alcohol Clin Exp Res. 1998 Dec;22(9):1912-20
9884133
Psychopharmacology (Berl). 1993;111(2):239-43
7870958
Psychopharmacology (Berl). 1997 Oct;133(4):329-42
9372531
Brain Res. 1999 Mar 13;821(2):350-5
10064821