FR227244, a novel antifungal antibiotic from Myrothecium cinctum No. 002 Taxonomy, fermentation, isolation and physico-chemical properties.
A novel antifungal antibiotic, FR227244, was isolated from the culture broth of a fungal strain No. 002. The strain was identified as Myrothecium cinctum from morphological and physiological characteristics. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatographies, and n-hexane precipitation. FR227244 is a white powder which melts at 210 to approximately 211 degrees C and possesses the molecular formula C38H58O11. FR227244 is a novel triterpene glycoside with antifungal activity against Aspergillus fumigatus. The effects of FR227244 on the morphology of A. fumigatus were shown to be similar to those of FR901379 which is a known 1,3-beta-glucan synthase inhibitor.
Kobayashi
Motoo
M
Fermentation Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. motoo_kobayashi@po.fujisawa.co.jp
Kanasaki
Ryuichi
R
Ezaki
Masami
M
Sakamoto
Kazutoshi
K
Takase
Shigehiro
S
Fujie
Akihiko
A
Hino
Motohiro
M
Hori
Yasuhiro
Y
D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry* / Q000145:classification / Q000648:ultrastructure; D001232:Aspergillus fumigatus / Q000187:drug effects; D002850:Chromatography, Gel; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008853:Microscopy; D008854:Microscopy, Electron; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; C498217:FR227244; D006027:Glycosides; D014315:Triterpenes