Transglutaminase function in epidermis.
Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium. This epithelium functions to protect the organism from the environment. Transglutaminases, enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key enzymes involved in the construction of this structure. This brief review will focus on the role of these enzymes in constructing the epidermal surface.
Eckert
Richard L
RL
Department of Physiology and Biophysics, Case School of Medicine, Cleveland, Ohio 44106, USA. rle2@po.cwru.edu
Sturniolo
Michael T
MT
Broome
Ann-Marie
AM
Ruse
Monica
M
Rorke
Ellen A
EA
D000078404:Epidermal Cells; D004817:Epidermis / Q000201:enzymology*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000201:enzymology*; D011503:Transglutaminases / Q000502:physiology*
D011503:Transglutaminases