title: A comparison of electronic monitoring vs. clinician rating of antipsychotic adherence in outpatients with schizophrenia.
abstract: Antipsychotic non-adherence rates of outpatients with schizophrenia or schizoaffective disorder was assessed by electronic monitoring and clinician rating. Antipsychotic adherence was determined monthly over 3 consecutive months with (1) the Medication Event Monitoring System (MEMS) cap and (2) the Clinician Rating Scale. Non-adherence was defined as daily adherence of <70% during any one of three monthly evaluations for MEMS and ratings of <or=4 (scale of 1-7) on the Clinician Rating Scale. Non-adherence was detected in 12 of 25 patients (48%) by MEMS and 0% by the Clinician Rating Scale. Clinician assessment dramatically underestimated antipsychotic non-adherence.
authors.affiliation: Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. Matt.Byerly@UTSouthwestern.edu
authors.forename: Matthew
authors.initials: M
authors.lastname: Byerly
authors.forename: Robert
authors.initials: R
authors.lastname: Fisher
authors.forename: Katrina
authors.initials: K
authors.lastname: Whatley
authors.forename: Rhiannon
authors.initials: R
authors.lastname: Holland
authors.forename: Femina
authors.initials: F
authors.lastname: Varghese
authors.forename: Thomas
authors.initials: T
authors.lastname: Carmody
authors.forename: Brianne
authors.initials: B
authors.lastname: Magouirk
authors.forename: A John
authors.initials: AJ
authors.lastname: Rush
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D016903:Drug Monitoring / Q000295:instrumentation*; D004581:Electronics / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008509:Medication Systems; D015588:Observer Variation; D010349:Patient Compliance / Q000706:statistics & numerical data*; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents