[Enhanced absorption of breviscapine photosomes in small intestine of rats].
OBJECTIVE
To investigate whether the absorption of breviscapine can be enhanced by using breviscapine photosomes.


METHODS
Testing the uptake and intestinal permeability of breviscapine powder and breviscapine photosomes by using intestine perfusion technique and reverted gut sac method.


RESULTS
The uptake and permeability coefficient of breviscapine were increased in photosomes. The absorption process obeyed the Fick's law in the range of 0-100 microg x mL(-1).


CONCLUSIONS
The absorption breviscapine photosomes is enhanced by increasing the permeability through a passive mechanism.
Tang
Xiao-qiao
XQ
Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.
Yang
Xiang-liang
XL
D000818:Animals; D019659:Asteraceae / Q000737:chemistry; D004337:Drug Carriers; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D004337:Drug Carriers; D005419:Flavonoids; D010743:Phospholipids; C061097:breviscapine