Immunity: it's in our bones.
Accumulating data suggest that the bone marrow is a reservoir for memory CD8+ T cells. In this issue of Immunity, show that bone marrow CD8+ T cells are predominantly CCR7+/CD62L+ "central memory" cells and describe specific signals that mediate their constitutive recruitment from the blood.
Woodland
David L
DL
Trudeau Institiute, Inc., Saranac Lake, NY 12983, USA.
Blackman
Marcia A
MA
D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D015398:Signal Transduction