The role of anti-CENP-B and anti-SS-B antibodies in breast cancer.
A close relationship between autoimmunity and malignant diseases has been supposed for a long time. In clinical practice, anti-SS-B and anti-CENP-B antibodies are used as serologic markers for autoimmune diseases. In this study, anti-SS-B and anti-CENP-B autoantibodies were studied in breast cancer patients and compared to a control group surgically treated due to benign diseases. These antibodies were evaluated by enzyme linked immunoassay and serum values >10 U/ml were accepted as positive. Fifty-five patients with breast cancer and 25 patients with benign diseases were prospectively included in the study. In the breast cancer group, both anti-CENP-B (33% vs. 8%) and anti-SS-B (44% vs. 24%) autoantibodies had higher positivity compared to the control group, but this difference reached statistical significance only for anti-CENP-B antibodies (p=0.02). Besides, anti-SS-B positivity was detected more frequently in breast cancer patients with axillary involvement (63% vs. 24%) (p=0.006) and increased as the number of involved lymph nodes increased in the axilla (p=0.03). Although the clinical significance of autoantibody detection in cancer patients is still not clear, autoantibodies especially detected in individuals without proven autoimmune diseases needs to be thoroughly evaluated for early diagnosis and treatment of various cancers.
Atalay
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Department of General Surgery, Ankara Oncology Teaching and Research Hospital, Demetevler, 06200 Ankara, Turkey. atalay_can@hotmail.com
Atalay
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G
Yilmaz
K B
KB
Altinok
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M
D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology*; D000912:Antibodies, Neoplasm / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D015551:Autoimmunity; D001941:Breast Diseases / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology*; D016022:Case-Control Studies; D002503:Centromere; D051936:Centromere Protein B; D002868:Chromosomal Proteins, Non-Histone / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000276:immunology*; D005260:Female; D006801:Humans; D008875:Middle Aged
D000974:Antibodies, Antinuclear; D000912:Antibodies, Neoplasm; D001324:Autoantigens; C497926:CENPB protein, human; D051936:Centromere Protein B; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; C035357:SS-B antibodies