title: Bilateral multiple malignant transformation of Ollier's disease.
abstract: We treated a 26-year-old man with a 19-year history of Ollier's disease. Secondary chondrosarcomas developed metachronously at four separate locations: both femora, left proximal tibia and fibular head. All four lesions were surgically excised, and each specimen was histologically identified as grade 1 or 2 chondrosarcoma. Clinical follow-up for 20 years beginning at the time of first tumor surgery has shown no evidence of local recurrence or metastasis. This is the first report of multiple bilateral metachronous malignant transformation of multiple chondromatoses in a patient with Ollier's disease.
authors.affiliation: Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan. n.kosaki@nifty.com
authors.forename: N
authors.initials: N
authors.lastname: Kosaki
authors.forename: H
authors.initials: H
authors.lastname: Yabe
authors.forename: U
authors.initials: U
authors.lastname: Anazawa
authors.forename: H
authors.initials: H
authors.lastname: Morioka
authors.forename: M
authors.initials: M
authors.lastname: Mukai
authors.forename: Y
authors.initials: Y
authors.lastname: Toyama
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D002813:Chondrosarcoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D004687:Enchondromatosis / Q000150:complications* / Q000000981:diagnostic imaging; D005266:Femoral Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging
references.citation: Hum Pathol. 1984 Jan;15(1):91-3
references.pmid: 6693116
references.citation: Radiographics. 1998 Sep-Oct;18(5):1213-37; quiz 1244-5
references.pmid: 9747616
references.citation: Skeletal Radiol. 2004 Aug;33(8):458-66
references.pmid: 15221215
references.citation: Clin Orthop Relat Res. 1985 Dec;(201):214-37
references.pmid: 4064409
references.citation: J Bone Joint Surg Am. 1982 Jan;64(1):95-103
references.pmid: 7054209
references.citation: Cancer. 1987 Apr 1;59(7):1376-85
references.pmid: 3815310
references.citation: J Orthop Sci. 2001;6(5):457-72
references.pmid: 11845358
references.citation: Skeletal Radiol. 1997 Jun;26(6):325-53
references.pmid: 9229417
references.citation: J Bone Joint Surg Am. 1987 Feb;69(2):269-74
references.pmid: 3805090
references.citation: Cancer. 1985 Feb 15;55(4):836-40
references.pmid: 3967176
references.citation: AJR Am J Roentgenol. 1997 Oct;169(4):1097-104
references.pmid: 9308471
references.citation: J Fla Med Assoc. 1990 Jan;77(1):24-8
references.pmid: 2405099
references.citation: Clin Orthop Relat Res. 1996 Jul;(328):211-9
references.pmid: 8653959
references.citation: Eur J Radiol. 1995 Nov;21(1):34-40
references.pmid: 8654456
references.citation: Eur J Radiol. 1998 May;27 Suppl 1:S86-90
references.pmid: 9652507