Legionella pneumonia and serum procalcitonin.
Procalcitonin is a specific marker of severe bacterial infections with systemic inflammation. Quantitative evaluation of serum procalcitonin was performed in 140 patients with Legionella pneumonia. Positive values (>0.5 ng/mL) were found in 57.1% of the subjects. The positive sample rate was higher in early sera (73.9% in the first week) and decreased progressively. Mean values and the positive sample rate (69.8%) were higher in sera collected in the first 2 weeks of disease. Procalcitonin was positive in 86.7% of legionellosis cases confirmed by culture and mean positive values were significantly higher (P < 0.001) than those of culture-negative subjects. We conclude that procalcitonin can represent a useful prognostic marker for severe suspected Legionella pneumonia in the first 2 weeks of disease.
Franzin
Laura
L
Infectious Diseases Unit, University of Turin, Corso Svizzera 164, Turin, 10149, Italy. franzin@asl3.to.it
Cabodi
Daniela
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007877:Legionnaires' Disease / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood*
C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide
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