title: Neuroprotection for ischemic stroke: two decades of success and failure.
abstract: Alteplase (rt-PA) is the first therapy successfully developed for acute stroke therapy. The success of rt-PA spurred development of new avenues for acute stroke management. For the last two decades, a great deal of attention has been paid to neuroprotective therapies. Initial preclinical studies demonstrated numerous drugs are effective for treating acute stroke in animal models; however, subsequent clinical trials have been frustrating, and none of the agents has proven effective. The various outcomes of preclinical and clinical trials have been the subject of much discussion. In this article, we review some key neuroprotective trials and the possible reasons for their failures. By identifying the discrepancies between preclinical studies and clinical trials, we may be able to set guidelines for future effective trials.
authors.affiliation: Stroke Center, University of California School of Medicine, and University of California San Diego, La Jolla, California, 92093-0624, USA.
authors.forename: Yu Dennis
authors.initials: YD
authors.lastname: Cheng
authors.forename: Lama
authors.initials: L
authors.lastname: Al-Khoury
authors.forename: Justin A
authors.initials: JA
authors.lastname: Zivin
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects*; D002986:Clinical Trials as Topic; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D018696:Neuroprotective Agents; D010959:Tissue Plasminogen Activator
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