title: The effect of a bi-annual professional application of APF foam on dental caries increment in primary teeth: 24-month clinical trial.
abstract: The purpose of this study was to evaluate the effect of a bi-annual professional application of acidulated phosphate fluoride (APF) foam on caries increment in the primary dentition over a two-year period in the People's Republic of China. In a double-blind, cluster-randomized, placebo-controlled trial, 392 children aged 3-4 years from 15 classes were randomly assigned to two groups on a school class basis. The experimental group (8 classes) received a bi-annual APF foam application, and the control group (7 classes) received the placebo. The mean increment of dmfs in the experimental group was 24.2% lower than that in the control group (p < 0.05). The significant caries reduction was observed on approximal surfaces in the experimental group compared with the control group (p < 0.01), but there were no differences on occlusal surfaces (p > 0.05). A bi-annual professional application of APF foam was effective in reducing the increment of dental caries in the primary teeth.
authors.affiliation: Department of Preventive Dentistry, School of Stomatology, Wuhan University, Luoyu Road 237, Wuhan City, China 430079.
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.forename: Z
authors.initials: Z
authors.lastname: Bian
authors.forename: B J
authors.initials: BJ
authors.lastname: Tai
authors.forename: M Q
authors.initials: MQ
authors.lastname: Du
authors.forename: B
authors.initials: B
authors.lastname: Peng
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D004245:DMF Index; D003729:Dental Care; D003731:Dental Caries / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D005460:Fluorides, Topical / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010919:Placebos; D012923:Social Class; D014094:Tooth, Deciduous / Q000187:drug effects*; D014099:Toothbrushing; D014100:Toothpastes / Q000627:therapeutic use
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; D010919:Placebos; D014100:Toothpastes; D000149:Acidulated Phosphate Fluoride; D005459:Fluorides