Retrieval improvement is induced by water shortage through angiotensin II.
Angiotensin II (ANGII) has an evolutionary preserved role in determining adaptative responses to water-shortages. In addition, it has been shown to modulate diverse phases of memory. Still, it is not clear whether ANGII improves or spoils memory. We demonstrated that endogenous angiotensins enhance consolidation of a long-term associative memory in the crab Chasmagnathus and that water shortage improves memory consolidation through brain ANGII actions. Here, we show that weakly trained crabs, when water-deprived, exhibit enhanced retrieval. Subsequently, memory retention is indistinguishable from that of strongly trained crabs. ANGII, but not angiotensin IV, is a necessary and sufficient condition for such enhancing effect. We conclude that ANGII released due to water shortage leads to enhanced memory retrieval. Thus, it seems that ANGII has an evolutionary preserved role as a multifunction coordinator that enables an adaptative response to water-shortage. The facilitation of memory consolidation and retrieval would be among those coordinated functions.
Frenkel
Lia
L
Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE-CONICET, Argentina.
Maldonado
Héctor
H
Delorenzi
Alejandro
A
D000222:Adaptation, Physiological; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001245:Association Learning / Q000502:physiology*; D005075:Biological Evolution; D003386:Brachyura; D011939:Mental Recall / Q000502:physiology*; D012153:Retention, Psychology / Q000502:physiology*; D014868:Water Deprivation / Q000502:physiology*
D000804:Angiotensin II