Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing.
The field of epidermal stem cells has dramatically advanced in the last decade, leading to a better understanding of the molecular factors, signalling pathways and cellular events that identify and characterize stem cells, thus revealing their immense potential for therapeutic use. Furthermore, multipotent epidermal stem cells present the major advantage of easy accessibility with the discovery of their specific location within the bulge of the hair follicle. This review focuses on the most recent findings on epidermal stem cells, and their potential role in initial epidermal commitment, differentiation and wound healing processes in the skin.
Morasso
Maria I
MI
Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. morassom@mail.nih.gov
Tomic-Canic
Marjana
M
D000818:Animals; D002454:Cell Differentiation; D000078404:Epidermal Cells; D004817:Epidermis / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000502:physiology; D051379:Mice; D013234:Stem Cells / Q000502:physiology*; D014945:Wound Healing
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