Evaluation of a physiologically-based pharmacokinetic approach for simulating the first-time-in-animal study.
Germani
Massimiliano
M
Pharmacokinetics, Dynamics and Metabolism, Nerviano Medical Sciences S.r.l., Via Pasteur 5, 20014 Nerviano, Milan, Italy.
Crivori
Patrizia
P
Rocchetti
Maurizio
M
Burton
Philip S
PS
Wilson
Alan G E
AG
Smith
Mark E
ME
Poggesi
Italo
I
D000818:Animals; D001549:Benzamides / Q000493:pharmacokinetics; D003975:Diazepam / Q000493:pharmacokinetics; D008954:Models, Biological; D010599:Pharmacokinetics; D011433:Propranolol / Q000493:pharmacokinetics; D051381:Rats
D001549:Benzamides; D011433:Propranolol; D003975:Diazepam