title: Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study.
abstract: OBJECTIVE
  To investigate the relation between change in systemic blood pressures and change in intraocular pressure.
  
  
  METHODS
  This was a population based study of people 43-86 years old living in Beaver Dam, Wisconsin. Measurements at baseline (1988-90) and 5 year follow up of systemic blood pressures, intraocular pressures, and history of use of blood pressure medications.
  
  
  RESULTS
  Intraocular pressures were significantly correlated with systolic and diastolic blood pressures at both baseline and follow up. There were significant direct correlations between changes in systemic blood pressures and changes in intraocular pressure. There was a 0.21 (95% CI: 0.16 to 0.27) mm Hg increase in IOP for a 10 mm Hg increase in systolic and 0.43 (0.35 to 0.52) mm Hg increase in IOP for a 10 mm Hg increase in diastolic blood pressure. Further adjustment for diabetes and medication use did not alter these associations. Decreased systolic or diastolic blood pressures of more than 10 mm Hg over 5 years were significantly associated with decreased IOP.
  
  
  CONCLUSIONS
  Reduced systemic blood pressure is associated with reduced intraocular pressure. This finding should be evaluated in other studies, especially with respect to the possibility of resultant decreased risk of open angle glaucoma.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI 53726-2336, USA. kleinb@epi.ophth.wisc.edu
authors.forename: B E K
authors.initials: BE
authors.lastname: Klein
authors.forename: R
authors.initials: R
authors.lastname: Klein
authors.forename: M D
authors.initials: MD
authors.lastname: Knudtson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination; D003971:Diastole; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000503:physiopathology / Q000517:prevention & control; D006306:Health Surveys; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D013599:Systole; D014065:Tonometry, Ocular; D014922:Wisconsin
chemical_list: D000959:Antihypertensive Agents
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