title: Neuroimaging and personality disorders.
abstract: Within the past several years, neuroimaging research on personality disorders has begun to develop. Personality disorders can be thought of as trait-like dysfunctional patterns in cognitive, affective, impulse control, and interpersonal domains. These domains of dysfunction have been linked to specific neural circuits. Developments in brain imaging techniques have allowed researchers to examine the neural integrity of these circuits in personality-disordered individuals. This article reviews the neuroimaging literature on borderline personality disorder, antisocial personality disorder (including psychopathy) and schizotypal personality disorder. Functional and structural studies provide support for dysfunction in fronto-limbic circuits in borderline and antisocial personality disorder, whereas temporal lobe and basal striatal-thalamic compromise is evident in schizotypal personality disorder.
authors.affiliation: Department of Psychiatry, MC #3077, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA. mmcclosk@yoda.bsd.uchicago.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: McCloskey
authors.forename: K Luan
authors.initials: KL
authors.lastname: Phan
authors.forename: Emil F
authors.initials: EF
authors.lastname: Coccaro
mesh_terms: D000987:Antisocial Personality Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001883:Borderline Personality Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D049268:Positron-Emission Tomography; D011859:Radiography; D012569:Schizotypal Personality Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology*; D015899:Tomography, Emission-Computed, Single-Photon
references.citation: Trends Cogn Sci. 1999 Jan;3(1):11-21
references.pmid: 10234222
references.citation: Schizophr Res. 2002 Mar 1;54(1-2):141-50
references.pmid: 11853988
references.citation: Crim Behav Ment Health. 2004;14(1):39-54
references.pmid: 14654860
references.citation: Schizophr Res. 1997 Feb 28;23(3):189-96
references.pmid: 9075296
references.citation: Psychiatry Res. 2000 Apr 10;93(3):237-46
references.pmid: 10760382
references.citation: Schizophr Res. 2004 Dec 1;71(2-3):249-62
references.pmid: 15474896
references.citation: J Neuropsychiatry Clin Neurosci. 2001 Fall;13(4):511-4
references.pmid: 11748321
references.citation: Behav Brain Res. 2000 May;109(2):177-86
references.pmid: 10762687
references.citation: Psychiatry Res. 1995 Jul 28;57(2):109-18
references.pmid: 7480378
references.citation: Arch Gen Psychiatry. 1989 Jul;46(7):587-99
references.pmid: 2735812
references.citation: Schizophr Res. 1997 Oct 17;27(1):21-8
references.pmid: 9373891
references.citation: Arch Gen Psychiatry. 2001 Feb;58(2):133-40
references.pmid: 11177115
references.citation: Neuropsychobiology. 2000;42(4):192-201
references.pmid: 11096335
references.citation: Biol Psychiatry. 2003 Jul 15;54(2):152-62
references.pmid: 12873805
references.citation: J Pers Disord. 1999 Winter;13(4):329-44
references.pmid: 10633314
references.citation: Neuroimage. 2003 Sep;20(1):385-92
references.pmid: 14527598
references.citation: Biol Psychiatry. 2000 Mar 15;47(6):540-7
references.pmid: 10715360
references.citation: Biol Psychiatry. 1997 Jul 15;42(2):96-103
references.pmid: 9209726
references.citation: Aust N Z J Psychiatry. 1999 Apr;33(2):187-96
references.pmid: 10336216
references.citation: Curr Psychiatry Rep. 2000 Feb;2(1):62-6
references.pmid: 11122934
references.citation: Schizophr Res. 1997 Oct 17;27(1):45-53
references.pmid: 9373894
references.citation: Am J Psychiatry. 2002 Jul;159(7):1190-7
references.pmid: 12091198
references.citation: Harv Rev Psychiatry. 2002 Jan-Feb;10(1):1-15
references.pmid: 11751641
references.citation: Schizophr Res. 1999 May 25;37(2):123-32
references.pmid: 10374648
references.citation: Biol Psychiatry. 2004 May 15;55(10):1001-6
references.pmid: 15121484
references.citation: Am J Psychiatry. 1998 Apr;155(4):509-15
references.pmid: 9545997
references.citation: Biol Psychiatry. 1999 Jun 1;45(11):1393-402
references.pmid: 10356620
references.citation: Psychiatry Res. 2004 Apr 30;130(3):213-25
references.pmid: 15135156
references.citation: J Affect Disord. 1998 Sep;50(2-3):235-43
references.pmid: 9858082
references.citation: J Psychiatr Res. 2003 Mar-Apr;37(2):109-15
references.pmid: 12842164
references.citation: J Psychiatr Res. 1997 Sep-Oct;31(5):531-41
references.pmid: 9368195
references.citation: Br J Psychiatry. 2003 Jan;182:5-7
references.pmid: 12509310
references.citation: Biol Psychiatry. 2002 Jun 15;51(12):951-63
references.pmid: 12062878
references.citation: Arch Gen Psychiatry. 2001 Sep;58(9):877-84
references.pmid: 11545672
references.citation: Am J Psychiatry. 2003 Dec;160(12):2198-201
references.pmid: 14638590
references.citation: Biol Psychiatry. 2001 Aug 15;50(4):292-8
references.pmid: 11522264
references.citation: Arch Gen Psychiatry. 1994 Dec;51(12):955-62
references.pmid: 7979884
references.citation: Psychiatry Res. 1994 Dec;55(4):237-45
references.pmid: 7701037
references.citation: Psychiatry Res. 2003 Apr 1;122(3):193-8
references.pmid: 12694893
references.citation: Psychiatry Res. 2003 Jul 30;123(3):153-63
references.pmid: 12928103
references.citation: Curr Psychiatry Rep. 2000 Oct;2(5):446-51
references.pmid: 11122995
references.citation: Biol Psychiatry. 2003 Jul 15;54(2):163-71
references.pmid: 12873806
references.citation: Am J Psychiatry. 2002 Sep;159(9):1521-7
references.pmid: 12202272
references.citation: Schizophr Res. 2001 Mar 30;48(2-3):187-99
references.pmid: 11295372
references.citation: Psychiatry Res. 2004 Jul 30;131(2):125-33
references.pmid: 15313519
references.citation: Neuropsychopharmacology. 1999 May;20(5):413-23
references.pmid: 10192822
references.citation: Am J Psychiatry. 1991 Dec;148(12):1647-58
references.pmid: 1957926
references.citation: Arch Gen Psychiatry. 2000 Dec;57(12):1115-22
references.pmid: 11115325
references.citation: Biol Psychiatry. 2004 Jan 15;55(2):185-91
references.pmid: 14732599
references.citation: Am J Psychiatry. 1999 Aug;156(8):1190-9
references.pmid: 10450259
references.citation: Curr Opin Neurobiol. 2004 Apr;14(2):254-8
references.pmid: 15082333
references.citation: Arch Gen Psychiatry. 2000 Feb;57(2):119-27; discussion 128-9
references.pmid: 10665614
references.citation: Annu Rev Neurosci. 2001;24:167-202
references.pmid: 11283309
references.citation: Biol Psychiatry. 2004 Apr 1;55(7):759-65
references.pmid: 15039006
references.citation: Psychol Med. 2002 Apr;32(3):417-27
references.pmid: 11989987
references.citation: Am J Psychiatry. 2001 Nov;158(11):1783-93
references.pmid: 11691682
references.citation: Eur Arch Psychiatry Clin Neurosci. 2002 Dec;252(6):268-77
references.pmid: 12563535
references.citation: Biol Psychiatry. 2001 Nov 1;50(9):677-84
references.pmid: 11704074
references.citation: Neuroimage. 2002 Jun;16(2):331-48
references.pmid: 12030820
references.citation: Biol Psychiatry. 2004 Jan 15;55(2):177-84
references.pmid: 14732598
references.citation: Psychiatry Res. 2002 Jun 15;114(2):95-102
references.pmid: 12036509
references.citation: Am J Psychiatry. 2000 Jan;157(1):48-54
references.pmid: 10618012
references.citation: J Anxiety Disord. 2005;19(1):1-28
references.pmid: 15488365
references.citation: Schizophr Res. 2000 May 5;42(3):193-208
references.pmid: 10785578
references.citation: Psychol Assess. 2002 Mar;14(1):27-38
references.pmid: 11911046
references.citation: Schizophr Res. 2003 Nov 1;64(1):35-9
references.pmid: 14511799
references.citation: Arch Gen Psychiatry. 2001 Jun;58(6):590-6
references.pmid: 11386989
references.citation: Psychol Med. 2002 Nov;32(8):1395-405
references.pmid: 12455938
references.citation: Psychiatry Res. 2004 Apr 30;130(3):297-312
references.pmid: 15209063
references.citation: Behav Brain Res. 2001 Jan 29;118(2):187-93
references.pmid: 11164516
references.citation: Arch Gen Psychiatry. 2003 Nov;60(11):1134-42
references.pmid: 14609889
references.citation: Biol Psychiatry. 2003 Dec 1;54(11):1284-93
references.pmid: 14643096