title: Schistosoma japonicum migration through mouse skin compared histologically and immunologically with S. mansoni.
abstract: The migration of Schistosoma japonicum and S. mansoni through mouse skin epidermis and dermis was compared by immunofluorescence techniques from 4 to 22 h after infection. At all times, the percentage of parasites detected in the dermis was significantly higher for S. japonicum than for S. mansoni. Thus, S. japonicum migrates more rapidly very early after infection. This agrees with the quicker migration observed previously by this species for later times. Both species expressed antigens related to the cercarial glycocalyx on the parasite body and antigenically detectable elastase in the acetabular glands, at least until 22 h after infection. Bot sets of antigens were also left as "traces" in cercarial migration channels in the skin as well as in skin tissue in the absence of detectable worms or migration channels. The data further substantiate differences between schistosome species in the speed of migration, and suggest that glycocalyx-related antigens and cercarial elastase continue to be expressed for at least 1 day after infection.
authors.affiliation: Department of Tropical Hygiene and Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120 , Heidelberg, Germany.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Yong-Long
authors.initials: YL
authors.lastname: Li
authors.forename: Zvi
authors.initials: Z
authors.lastname: Fishelson
authors.forename: John R
authors.initials: JR
authors.lastname: Kusel
authors.forename: Andreas
authors.initials: A
authors.lastname: Ruppel
mesh_terms: D000818:Animals; D020405:Dermis / Q000469:parasitology; D004817:Epidermis / Q000469:parasitology; D005455:Fluorescent Antibody Technique; D006652:Histological Techniques; D006790:Host-Parasite Interactions; D051379:Mice; D011817:Rabbits; D012549:Schistosoma japonicum / Q000254:growth & development / Q000502:physiology*; D012550:Schistosoma mansoni / Q000254:growth & development / Q000502:physiology*; D012554:Schistosomiasis japonica / Q000469:parasitology; D012555:Schistosomiasis mansoni / Q000469:parasitology; D012867:Skin / Q000469:parasitology*; D013997:Time Factors
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