Pathobiology of brain metastases.
Brain metastasis is a major cause of systemic cancer morbidity and mortality. Many factors participate in the development and maintenance of brain metastases. The survival of the metastasis depends upon crucial interactions between tumour cells and the brain microenvironment during its development at the new site. This review focuses on the pathobiological mechanisms involved in the establishment and regulation of brain metastases. Developments in molecular biology have vastly expanded our knowledge about the mechanisms of invasion, proliferation, metastatic cell signalling, and angiogenesis in brain metastases. Advances in this understanding of the pathobiology of brain metastasis may lead to novel targeted treatment paradigms and a better prognosis for patients with brain metastatic disease.
Nathoo
N
N
Brain Tumor Institute, Taussig Cancer Center and Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, Ohio 44122, USA.
Chahlavi
A
A
Barnett
G H
GH
Toms
S A
SA
D001932:Brain Neoplasms / Q000098:blood supply / Q000473:pathology / Q000556:secondary*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000235:genetics / Q000503:physiopathology*; D009389:Neovascularization, Pathologic; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000502:physiology
D025521:Tumor Suppressor Proteins; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
Drug News Perspect. 2001 Sep;14(7):401-11
12813583
Cancer Res. 2002 Nov 15;62(22):6717-23
12438272
Cancer Res. 1996 Oct 1;56(19):4387-90
8813131
Exp Cell Res. 2002 Feb 15;273(2):229-39
11822878
Brain Tumor Pathol. 2003;20(1):7-12
14604226
Int J Pancreatol. 2001;29(1):25-35
11558630
Folia Neuropathol. 1998;36(3):179-84
9833394
Curr Top Microbiol Immunol. 1996;213 ( Pt 2):89-115
9053298
Cancer Res. 1989 Dec 1;49(23):6449-65
2684393
Genes Chromosomes Cancer. 1996 Oct;17(2):71-7
8913723
Cell. 1991 Apr 5;65(1):25-35
2013093
J Biol Chem. 2002 Oct 11;277(41):38197-204
12145286
J Bioenerg Biomembr. 2003 Feb;35(1):73-9
12848344
Cancer Res. 2001 Jul 15;61(14):5644-51
11454719
Curr Pharm Des. 2003;9(19):1529-43
12871066
Int J Cancer. 1999 Oct 22;84(5):478-83
10502724
Cancer Res. 2000 Jun 1;60(11):2764-9
10850410
Cancer Res. 1999 May 15;59(10):2329-31
10344738
Cancer Res. 1999 Jan 15;59(2):442-9
9927060
Cell. 1994 Oct 21;79(2):185-8
7525076
N Engl J Med. 2000 Feb 24;342(8):525-33
10684910
Nat Cell Biol. 2000 Oct;2(10):737-44
11025665
Mol Carcinog. 1998 Feb;21(2):111-20
9496911
Lung Cancer. 2002 May;36(2):115-24
11955645
J Neuropathol Exp Neurol. 1994 May;53(3):256-62
8176408
Science. 1997 Mar 28;275(5308):1943-7
9072974
Nat Rev Cancer. 2003 Jan;3(1):55-63
12509767
Anticancer Res. 2002 Nov-Dec;22(6C):4265-8
12553067
Melanoma Res. 2004 Feb;14(1):23-7
15091190
J Clin Invest. 1991 Oct;88(4):1067-72
1833420
Pathol Oncol Res. 2003;9(3):147-58
14530807
Clin Cancer Res. 1999 Dec;5(12):4028-33
10632335
Adv Enzyme Regul. 2001;41:343-59
11384754
Neuro Oncol. 2004 Apr;6(2):154-65
15134630
Oncogene. 1998 Mar;16(11):1443-53
9525743
Cancer Treat Rev. 2003 Dec;29(6):533-40
14585263
Cancer Lett. 2003 Jul 30;198(1):1-20
12893425
Oncogene. 1998 May 7;16(18):2419-23
9620561
Clin Cancer Res. 1999 Sep;5(9):2431-7
10499615
Clin Exp Metastasis. 2004;21(2):107-18
15168728
Urol Oncol. 2000 Sep 1;5(5):217-223
10973711
Cancer Res. 2001 Oct 15;61(20):7422-5
11606374
Cancer Res. 1997 Jun 15;57(12):2384-7
9192814
Jpn J Cancer Res. 1998 Apr;89(4):397-404
9617345
J Neurooncol. 1994;22(2):101-10
7538161
Cancer Res. 1990 Oct 1;50(19):6130-8
1698118
J Pathol. 2003 Jul;200(4):448-64
12845612
Int J Oncol. 2000 Aug;17(2):217-25
10891528
Trends Cell Biol. 2001 Nov;11(11):S37-43
11684441
Cancer Surv. 1993;16:175-99
7688661
Cancer Res. 1990 Aug 1;50(15):4478-84
2369726
Nature. 1976 Jun 17;261(5561):595-7
819839
Adv Cancer Res. 2000;79:91-121
10818678
Cancer Res. 1999 Nov 1;59(21):5483-7
10554023
Recent Results Cancer Res. 2003;162:3-14
12790317
Cancer Res. 2002 Nov 15;62(22):6418-23
12438227
Br J Cancer. 1995 Jul;72(1):160-3
7541233
Cancer. 2000 Sep 1;89(5):955-62
10964324
Cancer Lett. 1997 Nov 11;119(2):149-55
9570365
Curr Treat Options Oncol. 2000 Dec;1(5):447-58
12057152
Science. 1998 Jun 5;280(5369):1614-7
9616126
Cancer Res. 2000 Sep 1;60(17):4959-67
10987313
Cancer Res. 1997 Oct 1;57(19):4177-82
9331070
Cancer Res. 2001 Apr 1;61(7):2833-7
11306453
Curr Biol. 2000 Aug 24;10(16):1009-12
10985391
Cancer Res. 1998 Jun 1;58(11):2350-2
9622073
Cancer Res. 2003 Apr 15;63(8):1731-6
12702552
J Neurooncol. 2000 Oct-Nov;50(1-2):173-80
11245277
Nature. 1980 Jan 10;283(5743):139-46
6985715
Genes Chromosomes Cancer. 1996 Jun;16(2):113-9
8818658
Cancer Res. 1997 Sep 1;57(17):3660-3
9288767
Cancer Res. 2000 Feb 1;60(3):749-55
10676663
Cancer Sci. 2004 Feb;95(2):142-8
14965364
Cancer Res. 1997 Mar 1;57(5):846-9
9041184
J Neurooncol. 2000;46(1):81-90
10896208
J Natl Cancer Inst. 1994 Aug 3;86(15):1167-9
8028038
Biochem Biophys Res Commun. 2001 Sep 7;286(5):958-63
11527393
Clin Exp Metastasis. 2000;18(6):519-25
11592309