title: [Second-line treatment of malignant pleural mesothelioma with Pemetrexed (Alimta) -- a case report].
abstract: Malignant Pleural Mesothelioma is regarded as a tumour, which lacks chemo-sensitivity. However, patients are able to benefit from a first line chemotherapy, as indicated in a currently published randomised study. Here the case of a 75 year old patient will be reported, who has been diagnosed with malignant pleural mesothelioma for 4 years. After a first line therapy with Gemcitabine/Oxaliplatin, partial remission was assessed. 15 months later a distinct progress was detected. After a second line therapy with Pemetrexed a sound partial response could be determined radiologically and clinically. This case history is supposed to exemplify that patients with malignant pleural mesothelioma should not only be considered for a first line therapy, but that a second line therapy may also be offered to a certain group of patients. The new substance Pemetrexed (Alimta) offers an excellent alternative with a very good efficacy profile and a favourable spectrum of side effects.
authors.affiliation: Städtisches Krankenhaus Martha-Maria Halle-Dölau gGmbH, Klinik für Innere Medizin II, Halle.
authors.forename: S
authors.initials: S
authors.lastname: Nagel
authors.forename: E
authors.initials: E
authors.lastname: Hobrack
authors.forename: P
authors.initials: P
authors.lastname: Jehle
authors.forename: W
authors.initials: W
authors.lastname: Schütte
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005541:Forced Expiratory Volume; D005971:Glutamates / Q000627:therapeutic use*; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000068437:Pemetrexed; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011725:Pyridines / Q000008:administration & dosage; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D005971:Glutamates; D009944:Organoplatinum Compounds; D011725:Pyridines; C431073:oxiplatin; D000068437:Pemetrexed; D003841:Deoxycytidine; D006147:Guanine; D000093542:Gemcitabine