title: Remission of natural-killer cell lymphoma of the liver with anti-hepatitis C therapy.
abstract: Non-Hodgkin lymphomas (NHL) consist of a diverse group of lymphoproliferative neoplasms with unique patterns of biology, behavior, and differing responses to therapy. A rare subtype of malignancy arising from cells of putative natural killer (NK) origin is being recognized as a distinct clinicopathological entity. Viruses including hepatitis C have been reported in association with various types of NHL but not the NK-cell subtype. We hereby report a unique case of a patient with hepatitis C who developed hepatic NK-cell lymphoma and chronic NK-cell leukemia. Interestingly, we observed clinical and radiologic remission of the neoplasm following treatment with anti-hepatitis C therapy.
authors.affiliation: Section of Hematology-Oncology and OU Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
authors.forename: Jess F
authors.initials: JF
authors.lastname: Armor
authors.forename: Javid
authors.initials: J
authors.lastname: Fazili
authors.forename: Nagib
authors.initials: N
authors.lastname: Toubia
authors.forename: William
authors.initials: W
authors.lastname: Kern
authors.forename: Rammurti
authors.initials: R
authors.lastname: Kamble
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Kharfan-Dabaja
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000473:pathology*; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology* / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012074:Remission Induction; D012254:Ribavirin / Q000627:therapeutic use; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology* / Q000821:virology
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012254:Ribavirin