title: Measuring the impact of venous leg ulcers on quality of life.
abstract: OBJECTIVE
  To identify health-related quality-of-life (HRQoL) issues in patients with venous leg ulcers, with the aim of generating items for a treatment outcome measure.
  
  
  METHODS
  Thirty-eight patients with venous leg ulcers were interviewed by a psychologist using a semi-structured guide; they also completed a HRQoL questionnaire (modified Skindex). Data from the questionnaire were examined to explore the impact of venous leg ulcers on patients' lives. Interview transcripts were analysed using qualitative methods to identify additional venous leg ulcer-specific HRQoL items.
  
  
  RESULTS
  Skindex scores indicated that older patients had worse HRQoL (p<0.05), as did those with pain and non-healing ulcers. Ulcer duration and size did not correlate with HRQoL. Interviews revealed the following effects of ulceration: pain (80.5%); itching (69.4%); altered appearance (66.7%); loss of sleep (66.6%); functional limitation (58.3%); and disappointment with treatment (50%). Based on the interview transcripts, items were generated and discussed with an expert panel, with a view to including them in a venous leg ulcer-specific HRQoL questionnaire.
  
  
  CONCLUSIONS
  Disease-specific HRQoL outcome measures should be considered when evaluating treatments for venous leg ulcers.
authors.affiliation: Worldwide Outcomes Research, Pfizer, Sandwich, UK. asha.hareendran@pfizer.com
authors.forename: A
authors.initials: A
authors.lastname: Hareendran
authors.forename: A
authors.initials: A
authors.lastname: Bradbury
authors.forename: J
authors.initials: J
authors.lastname: Budd
authors.forename: G
authors.initials: G
authors.lastname: Geroulakos
authors.forename: R
authors.initials: R
authors.lastname: Hobbs
authors.forename: J
authors.initials: J
authors.lastname: Kenkre
authors.forename: T
authors.initials: T
authors.lastname: Symonds
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D001828:Body Image; D017281:Cost of Illness; D005122:Exudates and Transudates; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D011537:Pruritus / Q000209:etiology; D036301:Qualitative Research; D011788:Quality of Life; D012649:Self Concept; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000209:etiology; D012919:Social Behavior; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000150:complications / Q000523:psychology* / Q000628:therapy; D014945:Wound Healing