Targeted contrast agents for magnetic resonance imaging and ultrasound.
The development of contrast agents that can be localized to a particular tissue or cellular epitope will potentially allow the noninvasive visualization and characterization of a variety of disease states. Recent advances have been made in the field of molecular imaging with magnetic resonance imaging and ultrasound and varied approaches have been devised to overcome the high background tissue signal. The types of agents and applications developed include gadolinium-conjugated targeting molecules for imaging of fibrin, superparamagnetic iron oxide particles for stem-cell tracking, multimodal perfluorocarbon nanoparticles for visualization of angiogenesis, liposomes for targeting atheroma components, and microbubbles for imaging transplant rejection.
Morawski
Anne M
AM
Washington University School of Medicine, Campus Box 8086, 660 South Euclid Avenue, St Louis, MO 63110, USA.
Lanza
Gregory A
GA
Wickline
Samuel A
SA
D000818:Animals; D003287:Contrast Media; D016503:Drug Delivery Systems / Q000379:methods*; D004452:Echocardiography / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015336:Molecular Probe Techniques
D003287:Contrast Media