Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.
Immunization with myelin antigens leads to the development of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. The disease can also be induced by the transfer of encephalitogenic CD4+ T helper (T(H)) lymphocytes into naive mice. These T cells need to re-encounter their cognate antigen in the context of major histocompatibility complex (MHC) class II-bearing antigen-presenting cells (APCs) in order to recognize their target. The cell type and location of the APC mediating T-cell entry into the central nervous system (CNS) remain unknown. Here, we show that APCs of the lymphoreticular system and of the CNS parenchyma are dispensable for the immune invasion of the CNS. We also describe that a discrete population of vessel-associated dendritic cells (DCs) is present in human brain tissue. In mice, CD11c+ DCs alone are sufficient to present antigen in vivo to primed myelin-reactive T cells in order to mediate CNS inflammation and clinical disease development.
Greter
Melanie
M
Neuroimmunology Unit, Department of Neurology, University Hospital Zurich, Frauenklinkstrasse 10, CH-8091 Switzerland.
Heppner
Frank L
FL
Lemos
Maria P
MP
Odermatt
Bernhard M
BM
Goebels
Norbert
N
Laufer
Terri
T
Noelle
Randolph J
RJ
Becher
Burkhard
B
D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology; D001921:Brain / Q000276:immunology* / Q000473:pathology; D039521:CD11c Antigen / Q000276:immunology; D002465:Cell Movement; D002678:Chimera; D003713:Dendritic Cells / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D005802:Genes, MHC Class II; D006801:Humans; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D009186:Myelin Sheath / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D039521:CD11c Antigen