title: Assessment of Tc-99m sestamibi tumor tissue uptake under the influence of increased arterial oxygen saturation.
abstract: The aim of this study is to investigate the potential effect of increased arterial saturation of oxygen in the magnitude of technetium-99m-hexakis-isobutyl-isonitrile (99mTc-MIBI) uptake in tumor tissue and to compare the results with those of conventional 99mTc-MIBI tumor imaging in the same patient with lung cancer. A total of 26 lung cancer patients underwent initial SPECT (I-SPECT) and after oxygen inhalation SPECT (O2-SPECT). The early (ER) and delayed ratios (DR) of O2-SPECT mean+/-S.D. were significantly higher than those of I-SPECT mean+/-S.D. (2.07+/-0.57 vs. 1.90+/-0.48 and 2.02+/-0.45 vs. 1.83+/-0.39, respectively). There are increased rates for the relative tumor uptake of 99mTc-MIBI by 9% for ER and 10% for DR on the O2-SPECT compared to I-SPECT. We found that 99mTc-MIBI uptake increased significantly in the tumor tissue with O2-SPECT compared to I-SPECT. In conclusion, 99mTc-MIBI scintigraphy is one of the main methods for differentiating viable and nonviable tissue fractions in tumors. We consider that 99mTc-MIBI uptake increase after oxygen inhalation is an indicator of positive acute cellular response of the tumor tissue to the rising tissue oxygen level.
authors.affiliation: Department of Nuclear Medicine, School of Medicine, Trakya University, Edirne 22030, Turkey.
authors.forename: Tevfik Fikret
authors.initials: TF
authors.lastname: Cermik
authors.forename: Gundeniz
authors.initials: G
authors.lastname: Altiay
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Firat
authors.forename: Osman N
authors.initials: ON
authors.lastname: Hatipoglu
authors.forename: Sakir
authors.initials: S
authors.lastname: Berkarda
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D001158:Arteries / Q000378:metabolism*; D015687:Cell Hypoxia; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D017256:Technetium Tc 99m Sestamibi / Q000493:pharmacokinetics*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi; D010100:Oxygen