Bone marrow stem cells in the infarcted heart.
Conventionally, the heart is perceived as a terminally differentiated organ, which is incapable of regeneration. Adult stem cell transplantation is aimed at replenishing the myocyte number to compensate for the cardiomyocyte loss during the process of cardiomyocyte necrosis following infarction. More recently, the focus has been shifted on the use of autologous skeletal myoblasts and bone marrow derived stem cells. Here, we have reviewed some interesting aspects of the fast emerging field of bone marrow derived stem cell therapy for cardiac repair.
Kh Haider
Husnain
H
Department of Pathology and Laboratory of Medicine, 231 Albert Sabinway, University of Cincinnati Ohio 45267 0529, USA.
Ashraf
Muhammad
M
D000818:Animals; D001853:Bone Marrow / Q000196:embryology*; D016026:Bone Marrow Transplantation; D006801:Humans; D009203:Myocardial Infarction / Q000628:therapy*; D013234:Stem Cells / Q000166:cytology*; D023822:Tissue Engineering