title: Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial.
abstract: Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.
authors.affiliation: Headache and Pain Unit, Neurology Department, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland.
authors.forename: P S
authors.initials: PS
authors.lastname: Sándor
authors.forename: L
authors.initials: L
authors.lastname: Di Clemente
authors.forename: G
authors.initials: G
authors.lastname: Coppola
authors.forename: U
authors.initials: U
authors.lastname: Saenger
authors.forename: A
authors.initials: A
authors.lastname: Fumal
authors.forename: D
authors.initials: D
authors.lastname: Magis
authors.forename: L
authors.initials: L
authors.lastname: Seidel
authors.forename: R M
authors.initials: RM
authors.lastname: Agosti
authors.forename: J
authors.initials: J
authors.lastname: Schoenen
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000517:prevention & control*; D016896:Treatment Outcome; D014451:Ubiquinone / Q000627:therapeutic use*
chemical_list: D014451:Ubiquinone