title: Radiation-induced cell death and dendritic cells: potential for cancer immunotherapy?
abstract: Dendritic cells are key orchestrators of the immune system. There is considerable interest in their use for treating cancer. Whether they initiate an effective cytotoxic response against antigen-bearing cells, or produce tolerance, depends on the context in which those antigens are presented. Ionising radiation, and the cell death it causes, has several properties that may facilitate such an effective response. A range of in-vitro and in-vivo data supports this, although potential problems exist that may require concurrent strategies.
authors.affiliation: Cancer Research UK Clinical Centre, St James's University Hospital, Leeds, UK. p.hatfield@cancermed.leeds.ac.uk
authors.forename: P
authors.initials: P
authors.lastname: Hatfield
authors.forename: A
authors.initials: A
authors.lastname: Merrick
authors.forename: K
authors.initials: K
authors.lastname: Harrington
authors.forename: R
authors.initials: R
authors.lastname: Vile
authors.forename: A
authors.initials: A
authors.lastname: Bateman
authors.forename: P
authors.initials: P
authors.lastname: Selby
authors.forename: A
authors.initials: A
authors.lastname: Melcher
mesh_terms: D000951:Antigens, Neoplasm; D017209:Apoptosis / Q000528:radiation effects*; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000502:physiology; D007167:Immunotherapy / Q000379:methods*; D009336:Necrosis; D009369:Neoplasms / Q000276:immunology / Q000532:radiotherapy; D011878:Radiotherapy
chemical_list: D000951:Antigens, Neoplasm