Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes.
D-type cyclins (cyclin D1, D2 and D3) and their associated cyclin-dependent kinases CDK4 and CDK6 were thought to represent important, perhaps essential components of the core cell cycle apparatus. However, recent analyses of mice lacking D-cyclins, or CDK4 and CDK6 reveal that these proteins are critically required for proliferation only in the selected cell types. Intriguingly, several compartments can develop in the absence of cyclin D-CDK4/6 activity, revealing that these cells can proliferate in a cyclin D-independent fashion.
Kozar
Katarzyna
K
Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Sicinski
Piotr
P
D000818:Animals; D002453:Cell Cycle; D049109:Cell Proliferation; D056741:Cyclin D; D051358:Cyclin-Dependent Kinase 4 / Q000737:chemistry*; D051361:Cyclin-Dependent Kinase 6 / Q000737:chemistry*; D016213:Cyclins / Q000737:chemistry*; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013997:Time Factors
D056741:Cyclin D; D016213:Cyclins; D051358:Cyclin-Dependent Kinase 4; D051361:Cyclin-Dependent Kinase 6