Do peptides control their own birth and death?
The tumour suppressor protein p53 and the Epstein-Barr-virus-encoded Epstein-Barr virus nuclear antigen-1 (EBNA1) can regulate their own proteasomal degradation and mRNA translation - in effect, they mediate control of their own steady-state levels. A large fraction of mRNA-translation-initiation events does not give rise to functional proteins; so could this reflect a more widespread concept by which certain proteins that require tight control of expression use similar means of self-regulation?
Fåhraeus
Robin
R
Institut de Pharmacologie, INSERM 716, Hôpital St Louis, 27 rue Juliette Dodu, 75010 Paris, France. robinfahraeus@yahoo.co.uk
D019309:Epstein-Barr Virus Nuclear Antigens / Q000235:genetics / Q000378:metabolism*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012269:Ribosomal Proteins / Q000235:genetics / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D019309:Epstein-Barr Virus Nuclear Antigens; D010455:Peptides; D012333:RNA, Messenger; D012269:Ribosomal Proteins; D016159:Tumor Suppressor Protein p53; C417029:EBV-encoded nuclear antigen 1