A novel isoform of Cbl-associated protein that binds protein kinase A.
A novel isoform of Cbl-associated protein (CAP) was identified in a yeast two-hybrid screen for A-kinase anchoring proteins expressed in the heart. CAP is a scaffold protein implicated in insulin signaling and cytoskeleton regulation. The protein kinase A binding site is encoded by a previously unidentified, alternatively spliced exon.
Matson
Sarah A
SA
Department of Pediatrics, Oregon Health and Science University, NRC5, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239, United States.
Pare
Genevieve C
GC
Kapiloff
Michael S
MS
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism*; D005091:Exons; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009206:Myocardium / Q000201:enzymology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D018909:src Homology Domains
D008840:Microfilament Proteins; D020033:Protein Isoforms; D011994:Recombinant Proteins; C432967:SORBS1 protein, human; D017868:Cyclic AMP-Dependent Protein Kinases