title: [Prostate cancer gene therapy].
abstract: With the advance in genetic engineering, tumor biology and immunology, gene therapy has been recognized as a promising new treatment option for cancer including prostate cancer. Several clinical trials of prostate cancer gene therapy are currently underway, using therapeutic genes which include suicide genes, immunomodulatory genes, tumor suppressor genes and anti-oncogenes. Although the gene therapy for prostate cancer as a clinical alternative is still early stage which requires several technological breakthrough, some information obtained from clinical trial indicates full potential of prostate cancer gene therapy. Concordant progress both in the basic research and gene therapy technology will make prostate cancer gene therapy ready for wide-scale of practice in the future. In this report, general concept and current progress in prostate cancer gene therapy are summarized.
authors.affiliation: Department of Urology, Okayama University Graduate School of Medicine and Dentistry.
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Nasu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kumon
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000998:Antiviral Agents / Q000627:therapeutic use; D019496:Cancer Vaccines; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000235:genetics; D005544:Forecasting; D015774:Ganciclovir / Q000627:therapeutic use; D041722:Genes, Transgenic, Suicide; D016147:Genes, Tumor Suppressor; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D005822:Genetic Vectors; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000628:therapy*; D018139:Simplexvirus / Q000201:enzymology; D013937:Thymidine Kinase / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D019496:Cancer Vaccines; D016207:Cytokines; D013937:Thymidine Kinase; D015774:Ganciclovir