title: Antimicrobial susceptibility of Shigella sonnei isolates in Japan and molecular analysis of S. sonnei isolates with reduced susceptibility to fluoroquinolones.
abstract: We performed susceptibility testing with Shigella sonnei isolates from imported and domestic cases of infection in Japan during 2001 and 2002. Some S. sonnei isolates were resistant to nalidixic acid, tetracycline, and trimethoprim-sulfamethoxazole. Most of the nalidixic acid-resistant strains showed reduced susceptibility to fluoroquinolones but did not show fluoroquinolone resistance.
authors.affiliation: Department of Bacteriology, National Institute of Infectious Diseases., 1-23-1-Toyama, Shinjuku, Tokyo 162-8640, Japan. hirosek@nih.go.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Hirose
authors.forename: Jun
authors.initials: J
authors.lastname: Terajima
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Izumiya
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Tamura
authors.forename: Eiji
authors.initials: E
authors.lastname: Arakawa
authors.forename: Nobuko
authors.initials: N
authors.lastname: Takai
authors.forename: Haruo
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology; D012764:Shigella sonnei / Q000187:drug effects* / Q000235:genetics
chemical_list: D024841:Fluoroquinolones; D009268:Nalidixic Acid
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