title: Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies.
abstract: An improved wound dressing with a long-term drug diffusion-efficacy has been developed by UV-radiation technique. It involves incorporation of ciprofloxacin (CIP), at the concentration of 0.5-2.0% (w/v), into a water mixture of 2-hydroxymethacrylate (HEMA) monomer, benzoin isobutyl ether (BIE) initiator and different content of ethylene glycol dimethacrylate (EGDMA) cross-linker. Increasing the concentration of EGDMA would reduce the releasing ratio of CIP from pHEMA. T1/2 is increased from 2.64 to 45.67 h when the EGDMA is added from 1 to 8%. In the ranges of 0< or = F < or = 0.6, the n value of 1%CIP-pHEMA membranes is increased from 0.48 to 0.81. It indicates that the mechanism of drug release falls between the Fickian and Case II diffusion model. The antibacterial activity of the drug impregnated into the membrane was evaluated by in vitro drug kinetic agar plate method. Higher concentration of EGDMA, up to 8% of the cross-linker, extends the drug release. Comparison with the drug-soaked membranes, the newly synthesized 1% CIP-pHEMA membrane (cross-linked with 4% EGDMA) sustains the release of the entrapped drug and maintains the antibacterial activity up to 12 days.
authors.affiliation: Institute of Preventive Medicine, National Defense Medical Center, National Defense University, P.O. Box 90048-700, Sanshia, Taipei, Taiwan, Republic of China. doky@ispeed.com.tw
authors.forename: Tai-Li
authors.initials: TL
authors.lastname: Tsou
authors.forename: Shang-Tao
authors.initials: ST
authors.lastname: Tang
authors.forename: Yu-Chuan
authors.initials: YC
authors.lastname: Huang
authors.forename: Jing-Ran
authors.initials: JR
authors.lastname: Wu
authors.forename: Jenn-Jong
authors.initials: JJ
authors.lastname: Young
authors.forename: Hsian-Jenn
authors.initials: HJ
authors.lastname: Wang
mesh_terms: D000042:Absorption; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D047070:Bandages, Hydrocolloid; D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry* / Q000528:radiation effects; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry* / Q000528:radiation effects; D004058:Diffusion; D006801:Humans; D007700:Kinetics; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry / Q000528:radiation effects; D011102:Polyhydroxyethyl Methacrylate / Q000032:analysis / Q000737:chemistry* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014946:Wound Infection / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D008689:Methacrylates; D011102:Polyhydroxyethyl Methacrylate; D002939:Ciprofloxacin; C004919:ethylene dimethacrylate
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