title: Variables affecting polarization-sensitive optical coherence tomography imaging examined through the modeling of birefringent phantoms.
abstract: Characteristics of tissue birefringence provide valuable diagnostic information when optical coherence tomography (OCT) imaging is performed. We mathematically model single-detector polarization-sensitive (PS) OCT (PS-OCT) for imaging an alternating layered phantom with birefringence. The theoretical analysis and the simulated data all reveal complexities associated with PS-OCT imaging. Various tissue parameters affect the retrieved PS-OCT signal and hence the image features. A better understanding of the mechanisms that control PS-OCT imaging would be useful for interpretation of tissue images and ultimately useful to provide more diagnostic information.
authors.affiliation: Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Michelle
authors.initials: M
authors.lastname: Harman
authors.forename: Mark E
authors.initials: ME
authors.lastname: Brezinski
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001718:Birefringence; D016000:Cluster Analysis; D003198:Computer Simulation; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods; D008859:Microscopy, Polarization / Q000295:instrumentation / Q000379:methods*; D008954:Models, Biological; D010363:Pattern Recognition, Automated / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*