Total synthesis of cytotoxic anhydrophytosphingosine pachastrissamine (jaspine B).
Starting from L-serine, a stereoselective synthesis of pachastrissamine, a structurally novel anhydrosphingosine derivative, is reported in this Letter. [structure: see text]
Bhaket
Pushpal
P
Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA.
Morris
Kay
K
Stauffer
Christina S
CS
Datta
Apurba
A
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry; D012694:Serine / Q000737:chemistry*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D013237:Stereoisomerism
D000970:Antineoplastic Agents; C468594:pachastrissamine; D012694:Serine; D013110:Sphingosine