A new immunomodulatory function of low-viscous konjac glucomannan with a small particle size: its oral intake suppresses spontaneously occurring dermatitis in NC/Nga mice.
BACKGROUND
Konjac glucomannan (GM) is a well-known dietary fiber with various beneficial functions: the higher viscosity displayed the stronger potency. However, the high-viscous GM powders, ordinary konjac powder and highly purified GM were mostly unsuitable for the application to various food industries. Our aims are to develop new physiological functions of low-viscous GM powder, pulverized GM or re-granulated fine GM, using a murine model of atopic dermatitis.


METHODS
Male 4-week-old NC/Nga mice were fed for 8 weeks on diets containing 5% of two high-viscous and two low-viscous GM powders, respectively.


RESULTS
Striking suppression against the aggravation of dermatitis, the increase in scratching behaviors, and the rise in IgE levels was recognized only in mice fed on the pulverized GM diet, but not in mice fed on the other GM diets or a control diet. Eczema prevention in the fine GM-fed mice was accompanied by a significant decrease in their plasma IFN-gamma levels, a positive regulatory cytokine for atopic skin inflammation.


CONCLUSIONS
Only the pulverized GM possessed the ability to suppress the development of dermatitis in NC/Nga mice. This is the new immunomodulatory function of low-viscous GM with a small particle size.
Onishi
Nobukazu
N
Department of Research and Development, Nishikawa Rubber Co., Ltd., Hiroshima, Japan. onishi@nishikawa-rbr.co.jp
Kawamoto
Seiji
S
Nishimura
Masaru
M
Nakano
Toshiaki
T
Aki
Tsunehiro
T
Shigeta
Seiko
S
Shimizu
Hisao
H
Hashimoto
Kunihiko
K
Ono
Kazuhisa
K
D000284:Administration, Oral; D000818:Animals; D002478:Cells, Cultured; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D015536:Down-Regulation; D007073:Immunoglobulin E / Q000097:blood; D007371:Interferon-gamma / Q000037:antagonists & inhibitors* / Q000097:blood; D015847:Interleukin-4 / Q000032:analysis / Q000276:immunology; D008297:Male; D008351:Mannans / Q000032:analysis / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D010316:Particle Size; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014783:Viscosity
D008351:Mannans; D015847:Interleukin-4; C022901:(1-6)-alpha-glucomannan; D007073:Immunoglobulin E; D007371:Interferon-gamma