Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. I. Taxonomy, fermentation, isolation and biological activities.
A new thiazolidine-type antibiotic with zinc in its structure, designated transvalencin A, was isolated from Nocardia sp. IFM 10065, a clinical isolate from a patient with actinomycotic mycetoma. The strain was identified as Nocardia transvalensis based on its morphological, phenotypic and phylogenetic characteristics. Transvalencin A showed antimicrobial activity against fungi such as Trichophyton mentagrophytes and Cryptococcus neoformans. The antibiotic is also active against Gram-positive bacteria such as Micrococcus luteus. We observed higher activity for fungi in an acidic medium than in a neutral medium.
Hoshino
Yasutaka
Y
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, Chiba 260-8673, Japan.
Mukai
Akira
A
Yazawa
Katsukiyo
K
Uno
Jun
J
Ishikawa
Jun
J
Ando
Akikazu
A
Fukai
Toshio
T
Mikami
Yuzuru
Y
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D008855:Microscopy, Electron, Scanning; D009615:Nocardia / Q000737:chemistry* / Q000145:classification / Q000648:ultrastructure; D009942:Organometallic Compounds / Q000302:isolation & purification / Q000494:pharmacology; D010802:Phylogeny; D013844:Thiazoles / Q000302:isolation & purification / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D013844:Thiazoles; C498222:transvalencin A; D015032:Zinc