Adverse events after botulinum A toxin injection for neurogenic voiding disorders.
OBJECTIVE
To review the side effects of local injections of botulinum A toxin (BTX-A).


METHODS
A medline search for publications about adverse events after injection of BTX-A for lower urinary tract dysfunctions.


RESULTS
We found four publications that report generalised side effects after BTX-A injection for detrusor overactivity (two) and detrusor-sphincter dyssynergia (two). The causes of generalised adverse events are not clear, but spread outside the target organ and into the systemic circulation may contribute. The dose used, the injection volume and the injection technique can all play a role.


CONCLUSIONS
Generalised side effects after BTX-A injection for voiding disorders are rare but they can be very disabling for spinal cord-injured patients. Although no long-term side effects are reported so far, urologists should be aware that these effects of BTX-A injections are unknown.
De Laet
K
K
Department of Urology, Faculty of Medicine, University of Antwerp, Belgium.
Wyndaele
J-J
JJ
D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000009:adverse effects; D010291:Paresis / Q000139:chemically induced* / Q000175:diagnosis*; D016896:Treatment Outcome; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy*; D014555:Urination Disorders / Q000188:drug therapy*
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A