title: Topical fusidic acid/betamethasone-containing gel compared to systemic therapy in the treatment of canine acute moist dermatitis.
abstract: The efficacy of a topical preparation containing 0.5% fusidic acid and 0.1% betamethasone-17-valerate was compared to a systemic therapy (comprising a combination of parenteral dexamethasone and oral clavulanate-potentiated amoxycillin) in the treatment of 104 dogs with acute moist dermatitis. Significant improvement was evident after seven days in both treatment groups in all clinical parameters assessed and there was no significant difference in the overall response between the two treatment groups. Staphylococcus intermedius was the most frequently isolated organism from swabs at the first visit (Day 0). No resistance to fusidic acid or clavulanate-potentiated amoxycillin was encountered. The study demonstrates no difference in the clinical improvement achieved in canine acute moist dermatitis following topical or systemic therapy and that both treatment regimes represent effective treatment options for the condition.
authors.affiliation: LEO Animal Health, Longwick Road, Princes Risborough, Buckinghamshire HP27 9RR, UK. malcolm.cobb@leo-pharma.com
authors.forename: M A
authors.initials: MA
authors.lastname: Cobb
authors.forename: H J
authors.initials: HJ
authors.lastname: Edwards
authors.forename: T D
authors.initials: TD
authors.lastname: Jagger
authors.forename: J
authors.initials: J
authors.lastname: Marshall
authors.forename: K E
authors.initials: KE
authors.lastname: Bowker
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001623:Betamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D003872:Dermatitis / Q000188:drug therapy / Q000662:veterinary*; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D004285:Dogs; D004739:England; D005260:Female; D005672:Fusidic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005782:Gels; D008297:Male; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005782:Gels; D005672:Fusidic Acid; D003907:Dexamethasone; D000658:Amoxicillin; D001623:Betamethasone