[The contribution of system regulation of pathogenicity-determining genes expression to the virulence of facultative intracellular parasites].
Bacteria which belong to the group of facultative parasites are capable of intensive proliferation both outside the organism and inside eukaryotic cells, thus often causing severe human and animal illness. The necessity of quick adaptation to the alteration of conditions after intrusion into the macro-organism gave rise to the development of complex genetic systems, regulating the activity of various gene groups. The review, written by the example of two pathogen bacteria, the gram-positive Listeria monocytogenes and the gram-negative Legionella pneumophila, illustrates up-to-date data that concern system regulation of genes, coding pathogenicity factors, as adaptive response of a bacterium to changes in outer conditions within the infectious process.
Ermolaeva
S A
SA
Romanova
Iu M
IuM
Tartakovskiĭ
I S
IS
D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000235:genetics / Q000382:microbiology / Q000473:pathology; D003600:Cytosol / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial; D006801:Humans; D009154:Mutation / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D014774:Virulence / Q000235:genetics