International clone of Neisseria meningitidis serogroup A with tetracycline resistance due to tet(B).
Thirteen Neisseria meningitidis clinical isolates from Africa, Asia, and the United States for which the tetracycline MICs were elevated (> or =8 microg/ml) were examined for 14 recognized resistance genes. Only the drug efflux mechanism encoded by tet(B) was detected. All isolates were in serogroup A, belonged to complex ST-5, and were closely related by pulsed-field gel electrophoresis analysis.
Crawford
Sharon A
SA
Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900, USA.
Fiebelkorn
Kristin R
KR
Patterson
Jan E
JE
Jorgensen
James H
JH
D016521:Electrophoresis, Gel, Pulsed-Field; D005798:Genes, Bacterial; D008826:Microbial Sensitivity Tests; D009345:Neisseria meningitidis / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D012703:Serotyping; D013753:Tetracycline Resistance / Q000235:genetics*
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