title: [Diagnostic difficulties in the laryngeal malignant peripheral nerve sheath tumor (MPNST)].
abstract: The malignant tumor deriving from the peripheral nerve sheet, previously described as malignant Schwannoma or neurosarcoma is extremely rare as malignancy localized in the larynx. The half of cases has been developing on the basis of neurofibromatosis in von Recklinghausen disease type I or seldom, type II. The high grade of malignancy end tendency to reccurences and distant metastases is typical for this tumors. The case of 64 year old man with larynx neurosarcoma was presented. The diagnostic difficulties were caused by clinical presentation of the smooth tumor covered by unchanged mucosa and typical histological features of the tumor. The final histological assessment was complemented by positive immunohistochemical reaction (antigens against protein S-100, NSE and PG 9.5).
authors.affiliation: Klinika Otolaryngologii i Onkologii Laryngologicznej AM im. Karola Marcinkowskiego w Poznaniu.
authors.forename: Maciej
authors.initials: M
authors.lastname: Pabiszczak
authors.forename: Aldona
authors.initials: A
authors.lastname: Woźniak
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wierzbicka
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Leszczyńska
authors.forename: Witold
authors.initials: W
authors.lastname: Szyfter
mesh_terms: D018219:Histiocytoma, Benign Fibrous / Q000473:pathology / Q000601:surgery; D006801:Humans; D007823:Laryngeal Nerves / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018317:Nerve Sheath Neoplasms / Q000473:pathology* / Q000601:surgery; D009442:Neurilemmoma / Q000473:pathology* / Q000601:surgery; D012509:Sarcoma / Q000473:pathology / Q000601:surgery; D014140:Tracheotomy