title: The role of natural killer cells in tumor control--effectors and regulators of adaptive immunity.
abstract: Natural killer (NK) cells are the primary effector cells of the innate immune system and have a well-established role in tumor rejection in a variety of spontaneous and induced cancer models. NK cell function is regulated by a complex balance of inhibitory and activating signals that allow them to selectively target and kill cells that display an abnormal pattern of cell surface molecules, while leaving normal healthy cells unharmed. In this review we discuss NK cell function, the role of NK cells in cancer therapies, the emerging concept of bi-directional cross-talk between NK cells and dendritic cells, and the implications of these interactions for tumor immunotherapy.
authors.affiliation: Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, 8006, East Melbourne, Victoria, Australia.
authors.forename: Morgan E
authors.initials: ME
authors.lastname: Wallace
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Smyth
mesh_terms: D000818:Animals; D002450:Cell Communication; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy
references.citation: Nat Rev Immunol. 2003 Apr;3(4):304-16
references.pmid: 12669021
references.citation: Nat Med. 1999 Apr;5(4):405-11
references.pmid: 10202929
references.citation: Cytokine Growth Factor Rev. 2002 Apr;13(2):95-109
references.pmid: 11900986
references.citation: J Exp Med. 2001 Mar 19;193(6):661-70
references.pmid: 11257133
references.citation: J Leukoc Biol. 2002 Feb;71(2):173-83
references.pmid: 11818437
references.citation: J Exp Med. 2003 Aug 4;198(3):433-42
references.pmid: 12900519
references.citation: Cell. 2001 Aug 10;106(3):255-8
references.pmid: 11509172
references.citation: J Immunol. 2001 Jun 1;166(11):6477-82
references.pmid: 11359797
references.citation: Immunol Rev. 2001 Jun;181:158-69
references.pmid: 11513137
references.citation: Nature. 1997 Jul 10;388(6638):190-5
references.pmid: 9217161
references.citation: J Exp Med. 2004 Mar 15;199(6):879-84
references.pmid: 15007091
references.citation: Blood. 2001 Jan 1;97(1):192-7
references.pmid: 11133760
references.citation: J Immunol. 2000 Sep 1;165(5):2665-70
references.pmid: 10946296
references.citation: Nat Med. 1999 Nov;5(11):1249-55
references.pmid: 10545990
references.citation: J Immunol. 2001 Aug 15;167(4):2068-73
references.pmid: 11489989
references.citation: J Immunol. 2003 Jul 15;171(2):515-8
references.pmid: 12847210
references.citation: Immunity. 2003 Oct;19(4):561-9
references.pmid: 14563320
references.citation: J Exp Med. 1997 Nov 3;186(9):1609-14
references.pmid: 9348320
references.citation: Curr Top Microbiol Immunol. 1998;230:221-44
references.pmid: 9586358
references.citation: J Exp Med. 2002 Feb 4;195(3):335-41
references.pmid: 11828008
references.citation: J Immunol. 1998 Dec 1;161(11):5821-4
references.pmid: 9834059
references.citation: Eur J Immunol. 2001 Jan;31(1):39-47
references.pmid: 11169436
references.citation: Int J Cancer. 1985 Apr 15;35(4):505-13
references.pmid: 2985510
references.citation: Eur J Immunol. 1995 Dec;25(12):3514-6
references.pmid: 8566046
references.citation: Leuk Lymphoma. 1995 Aug;18(5-6):471-8
references.pmid: 8528055
references.citation: Immunol Rev. 2001 Jun;181:90-103
references.pmid: 11513155
references.citation: Nat Immunol. 2001 Sep;2(9):882-8
references.pmid: 11526406
references.citation: J Exp Med. 2000 Feb 7;191(3):423-34
references.pmid: 10662788
references.citation: Immunology. 2004 Jun;112(2):177-82
references.pmid: 15147560
references.citation: J Immunol. 2004 Jan 1;172(1):123-9
references.pmid: 14688317
references.citation: J Exp Med. 2000 Sep 4;192(5):755-60
references.pmid: 10974040
references.citation: Blood. 2004 Sep 15;104(6):1778-83
references.pmid: 15166032
references.citation: Immunity. 2000 Jul;13(1):143-53
references.pmid: 10933402
references.citation: J Immunol. 1993 Jul 1;151(1):60-70
references.pmid: 8326140
references.citation: Int Immunol. 2001 Apr;13(4):459-63
references.pmid: 11282985
references.citation: J Exp Med. 2002 Feb 4;195(3):327-33
references.pmid: 11828007
references.citation: Nat Immunol. 2002 Dec;3(12):1142-9
references.pmid: 12426565
references.citation: J Immunol. 1999 Dec 15;163(12):6365-70
references.pmid: 10586025
references.citation: J Immunol. 1998 Sep 15;161(6):2833-40
references.pmid: 9743343
references.citation: Semin Immunol. 1998 Oct;10(5):351-3
references.pmid: 9799709
references.citation: J Exp Med. 2004 Aug 2;200(3):287-95
references.pmid: 15289500
references.citation: Curr Opin Immunol. 1995 Oct;7(5):704-10
references.pmid: 8573315
references.citation: J Hematother. 1995 Aug;4(4):269-79
references.pmid: 7489141
references.citation: Anticancer Res. 2003 Nov-Dec;23(6a):4369-76
references.pmid: 14666723
references.citation: Proc Natl Acad Sci U S A. 2003 May 27;100(11):6682-7
references.pmid: 12724523
references.citation: J Immunol. 2002 Feb 1;168(3):1356-61
references.pmid: 11801676
references.citation: Pathol Biol (Paris). 2003 Mar;51(2):67-8
references.pmid: 12801803
references.citation: J Immunol. 1999 Jun 1;162(11):6658-62
references.pmid: 10352283
references.citation: J Exp Med. 2002 Feb 4;195(3):343-51
references.pmid: 11828009
references.citation: J Exp Med. 2000 Feb 21;191(4):661-8
references.pmid: 10684858
references.citation: J Exp Med. 1985 Dec 1;162(6):1745-59
references.pmid: 3877776
references.citation: J Exp Med. 1991 Apr 1;173(4):1017-20
references.pmid: 2007850
references.citation: J Immunol. 2004 Feb 1;172(3):1455-62
references.pmid: 14734722
references.citation: Nat Rev Immunol. 2001 Oct;1(1):41-9
references.pmid: 11905813
references.citation: J Exp Med. 2002 Jan 21;195(2):161-9
references.pmid: 11805143
references.citation: Immunol Today. 1995 Apr;16(4):202-6
references.pmid: 7734049
references.citation: Nat Rev Immunol. 2002 Oct;2(10):735-47
references.pmid: 12360212
references.citation: J Immunol. 2004 Jul 15;173(2):900-9
references.pmid: 15240677
references.citation: Adv Cancer Res. 2003;90:127-56
references.pmid: 14710949
references.citation: J Immunol. 2002 Oct 1;169(7):3676-85
references.pmid: 12244160
references.citation: J Exp Med. 1996 Nov 1;184(5):1845-56
references.pmid: 8920872
references.citation: J Immunol. 2002 Nov 15;169(10):5377-81
references.pmid: 12421908
references.citation: Science. 2002 Mar 15;295(5562):2097-100
references.pmid: 11896281
references.citation: Cancer Res. 1995 Jul 1;55(13):2730-3
references.pmid: 7540948
references.citation: J Exp Med. 2000 Mar 6;191(5):771-80
references.pmid: 10704459
references.citation: Nature. 2001 Sep 13;413(6852):165-71
references.pmid: 11557981
references.citation: Science. 1999 Dec 3;286(5446):1957-9
references.pmid: 10583959
references.citation: Curr Opin Oncol. 2003 Nov;15(6):440-5
references.pmid: 14624226
references.citation: Immunol Lett. 2001 Feb 1;76(1):37-41
references.pmid: 11222911
references.citation: Cancer J Sci Am. 2000 Feb;6 Suppl 1:S2-7
references.pmid: 10685650
references.citation: J Immunol. 1986 Jun 15;136(12):4480-6
references.pmid: 3086432
references.citation: Nat Rev Cancer. 2002 Nov;2(11):850-61
references.pmid: 12415255
references.citation: Int J Cancer. 2003 Feb 10;103(4):508-13
references.pmid: 12478667
references.citation: Immunity. 2003 Jan;18(1):1-6
references.pmid: 12530970
references.citation: Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10116-21
references.pmid: 15218108
references.citation: J Immunol. 2004 Feb 15;172(4):2048-58
references.pmid: 14764669
references.citation: Annu Rev Immunol. 1999;17:19-49
references.pmid: 10358752
references.citation: J Invest Dermatol. 2002 Oct;119(4):850-7
references.pmid: 12406330
references.citation: Nat Immunol. 2001 Oct;2(10):951-6
references.pmid: 11550009
references.citation: FASEB J. 1994 Oct;8(13):1012-8
references.pmid: 7926365
references.citation: Nat Med. 2001 Jan;7(1):94-100
references.pmid: 11135622
references.citation: Nat Immunol. 2002 Jan;3(1):83-90
references.pmid: 11743585
references.citation: Int J Cancer. 1975 Jun 15;15(6):933-40
references.pmid: 1150347
references.citation: Nature. 1986 Feb 20-26;319(6055):675-8
references.pmid: 3951539
references.citation: Trends Immunol. 2001 Nov;22(11):633-40
references.pmid: 11698225
references.citation: Annu Rev Immunol. 1998;16:359-93
references.pmid: 9597134
references.citation: J Immunol. 2004 Feb 1;172(3):1333-9
references.pmid: 14734707
references.citation: Nature. 1998 Mar 19;392(6673):245-52
references.pmid: 9521319
references.citation: Nat Immunol. 2001 Oct;2(10):917-24
references.pmid: 11577347
references.citation: Science. 1999 Jul 30;285(5428):727-9
references.pmid: 10426993
references.citation: J Exp Med. 2001 Sep 17;194(6):863-9
references.pmid: 11561001
references.citation: Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4778-83
references.pmid: 10781084
references.citation: Semin Immunol. 1995 Apr;7(2):89-101
references.pmid: 7579199
references.citation: Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11521-6
references.pmid: 11562472
references.citation: J Natl Cancer Inst. 2004 May 5;96(9):651-3
references.pmid: 15126597
references.citation: J Allergy Clin Immunol. 1990 Feb;85(2):453-9
references.pmid: 2303649
references.citation: Immunol Res. 1998;17(1-2):269-78
references.pmid: 9479588
references.citation: Mol Immunol. 2002 Feb;38(9):637-60
references.pmid: 11858820
references.citation: Blood. 2002 Sep 1;100(5):1728-33
references.pmid: 12176894
references.citation: Eur J Immunol. 2003 Feb;33(2):306-13
references.pmid: 12548561
references.citation: Eur J Immunol. 2003 Jun;33(6):1657-66
references.pmid: 12778484
references.citation: Science. 1991 Jul 12;253(5016):199-202
references.pmid: 1853205
references.citation: Curr Opin Immunol. 2002 Oct;14(5):615-21
references.pmid: 12183162
references.citation: Immunity. 2002 Apr;16(4):559-69
references.pmid: 11970879
references.citation: Nat Rev Immunol. 2003 May;3(5):413-25
references.pmid: 12766763
references.citation: Nat Rev Immunol. 2002 Mar;2(3):151-61
references.pmid: 11913066
references.citation: Eur J Immunol. 2003 Apr;33(4):827-33
references.pmid: 12672047
references.citation: J Exp Med. 2002 Feb 4;195(3):F9-14
references.pmid: 11828015
references.citation: Nat Immunol. 2004 Dec;5(12):1260-5
references.pmid: 15531883
references.citation: J Immunol. 2002 May 1;168(9):4472-9
references.pmid: 11970991
references.citation: Trends Immunol. 2004 Jan;25(1):47-52
references.pmid: 14698284
references.citation: Cancer Res. 1994 Jul 15;54(14):3808-16
references.pmid: 8033100
references.citation: Immunity. 2003 Jul;19(1):5-8
references.pmid: 12871634
references.citation: Semin Immunol. 2002 Dec;14(6):453-60
references.pmid: 12457618
references.citation: Nat Immunol. 2002 Jun;3(6):523-8
references.pmid: 12006976