The impact of lipophilicity in drug research: a case report on beta-blockers.
The key importance of lipophilicity in bio-studies is discussed for beta-blockers. Examples of their lipophilicity-dependent pharmacological properties including pharmacokinetic, pharmacodynamic and clinical aspects are reviewed. Comprehensive lipophilicity compilations of beta-blockers are lacking so far. LogP calculations with 10 programs for 30 clinically relevant beta-blockers are presented for the first time in this review.
Mannhold
Raimund
R
Department of Laser Medicine, Molecular Drug Research Group, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. mannhold@uni-duesseldorf.de
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D010600:Pharmacology
D000319:Adrenergic beta-Antagonists; D008055:Lipids