Antiallergic, antipyretic, hypoglycemic and hepatoprotective effects of aqueous extract of Coronopus didymus Linn.
The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 mg/kg doses on oral administration. Mechanistically, CD acts as an antioxidant as evidenced by its ability to scavenge DPPH and superoxide radicals. All the observed activities may be due to the presence of flavonoids, saponins and tannins as they are reported to possess a variety of biological activities.
Mantena
Sudheer Kumar
SK
Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India. sudheerkumarm99@yahoo.com
Mutalik
Srinivasa
S
Srinivasa
Hullegala
H
Subramanian
Ganesa Sundararajan
GS
Prabhakar
Koiram Rajanna
KR
Reddy
Kasu Raghurami
KR
Srinivasan
Keloth Kaitheri
KK
Unnikrishnan
Mazhuvancherry Kesavan
MK
D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D019607:Brassicaceae; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D014867:Water
D018712:Analgesics, Non-Narcotic; D018926:Anti-Allergic Agents; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014867:Water