Transforming growth factor-beta : biology and clinical relevance.
Transforming growth factor-beta is a pleiotropic growth factor that has enthralled many investigators for approximately two decades. In addition to many reports that have clarified the basic mechanism of transforming growth factor-beta signal transduction, numerous laboratories have published on the clinical implication/application of transforming growth factor-beta . To name a few, dysregulation of transforming growth factor-beta signaling plays a role in carcinogenesis, autoimmunity, angiogenesis, and wound healing. In this report, we will review these clinical implications of transforming growth factor-beta .
Kim
Isaac Yi
IY
Department of Urology, University of California at Irvine, Orange, CA 92868, USA.
Kim
Moses M
MM
Kim
Seong-Jin
SJ
D001695:Biology; D006801:Humans; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016212:Transforming Growth Factor beta