Inhibition of blood platelet adhesion and secretion by different phenolics from Yucca schidigera Roezl. bark.
OBJECTIVE
Yucca schidigera is a plant that grows in Mexico, and it has a very high level of saponins and phenolic compounds with antioxidant action. The products of Y. schidigera are used as food additives and have a generally recognized as safe label. This study investigated the antiplatelet mechanisms of four phenolic compounds.


METHODS
We investigated antiplatelet mechanisms of the phenolic compounds trans-3,4',5-trihydroxystilbene (trans-resveratrol), trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene, and yuccaols A and C that had been isolated from the bark of Y. schidigera by studying their effects on the first step of platelet activation, i.e., platelet adhesion to collagen and fibrinogen. The effects of these compounds on the release of adenine nucleotides, proteins, and beta-N-acetyl-glycosaminidase (a marker of lysosomal secretion) from blood platelets activated by thrombin were also studied.


RESULTS
These different phenolic compounds (1 to 25 microg/mL) and their extracts decreased platelet adhesion and secretion.


CONCLUSIONS
Resveratrol and yucca extract were more reactive in decreasing these processes than were other tested phenolic compounds.
Olas
Beata
B
Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland.
Wachowicz
Barbara
B
Stochmal
Anna
A
Oleszek
Wieslaw
W
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005340:Fibrinogen / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology; D013552:Swine; D027623:Yucca / Q000737:chemistry*
D010636:Phenols; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; D005340:Fibrinogen; D003094:Collagen; D000077185:Resveratrol