[Stage IV Wilms' tumour -- analysis of treatment results, according to the SIOP 93-01 protocol, at the Medical University of Gdańsk].
OBJECTIVE
To evaluate the results of treatment in patients with Wilm's' tumor in stage IV at the Gdansk Medical University Centre.


METHODS
Between 1993 and 2002, 44 children with nephroblastoma were treated according to SI0P 93-01 protocol, in the Department of Paediatrics, Haematology, Oncology and Endocrinology of the Medical University of Gdansk. Stage IV tumour was confirmed in 6 children: 3 boys and 3 girls. Metastases into the lungs were identified in 4 patients, into the lungs and liver in l child and into the right atrium wall in l child.


RESULTS
After preoperative chemotherapy complete regression of metastases was obtained in 3 patients. Partial regression was obtained in 2 patients. In l patient there was no effect of preoperative treatment. In all patients nephroblastoma of intermediate histological risk was diagnosed. Among the 6 analysed patients with stage IV of the disease, 5 children are alive. Time of observation is from 42 to 102 months. 1 child died from treatment complications: necrotising enteritis.
Stefanowicz
Joanna
J
Klinika Pediatrii, Hematologii, Onkologii i Endokrynologii, Akademia Medyczna, Debinki 7, 80-211 Gdańsk, Poland.
Sierota
Danuta
D
Połczyńska
Katarzyna
K
Balcerska
Anna
A
Stoba
Czesław
C
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003609:Dactinomycin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D011044:Poland; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000188:drug therapy* / Q000473:pathology*
D003609:Dactinomycin; D014750:Vincristine