Design and study of rifampicin oral controlled release formulations.
Oral controlled release formulations of rifampicin have been developed by using hydroxypropyl methylcellulose polymer at different ratios. From in vitro release data, we found that the release was extended with an increase of polymer proportion from 20% to 40%. However, increase in polymer beyond 40% resulted in no significant change in the release rate. There was a distinct difference in the release rate and release character due to variation in the compression force. The release kinetics were analyzed using Ritger and Peppas exponential equation. Stability studies at ambient storage conditions for 1 year showed that formulations were stable.
Hiremath
S P
SP
Pharmacy Group, Birla Institute of Technology and Science, Pilani, India.
Saha
R N
RN
D000465:Algorithms; D000904:Antibiotics, Antitubercular / Q000737:chemistry / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019245:Compressive Strength; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D004355:Drug Stability; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D015203:Reproducibility of Results; D012293:Rifampin / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility; D013607:Tablets
D000904:Antibiotics, Antitubercular; D003692:Delayed-Action Preparations; D013607:Tablets; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D012293:Rifampin