Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70.
Inflammation may play an important role in the pathophysiology of sickle cell disease (SCD), and recent studies have identified the 70-kDa heat shock protein (Hsp70) as an important mediator of inflammatory responses. Here we demonstrate a significant increase in circulating serum Hsp70 level in SCD during vaso-occlusive crisis (VOC) as compared with baseline steady-state levels (P <0.05) and a significant increase in Hsp70 levels in SCD at baseline compared with normal controls (P <0.05). Taken together, these results indicate that circulating serum Hsp70 might be a marker for VOC in SCD.
Adewoye
Adeboye H
AH
Center for Excellence in Sickle Cell Disease, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Klings
Elizabeth S
ES
Farber
Harrison W
HW
Palaima
Elizabeth
E
Bausero
Maria A
MA
McMahon
Lillian
L
Odhiambo
Adam
A
Surinder
Safaya
S
Yoder
Mark
M
Steinberg
Martin H
MH
Asea
Alexzander
A
D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications; D015415:Biomarkers / Q000097:blood; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D014652:Vascular Diseases / Q000097:blood* / Q000209:etiology
D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins
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