Antihypertensive pharmacogenetics.
Essential hypertension is a complex disease in which multiple genetic and environmental factors interact to produce the phenotype. The genetic contribution to blood pressure variations is estimated to range from 30% to 50%. In this review we describe some of the genes and genetic polymorphisms that have been most consistently related to blood pressure elevation and also the importance of pharmacogenetics and the emerging evidence of genetic influences on antihypertensive drug responses, with the potential for getting the right drug into the right patient based on the individual genetic profile.
Nogueira
J Braz
JB
Medicina 1, Hospital de Santa Maria, Faculdade de Medicina de Lisboa Lisboa, Portugal. braznogueira@fm.ul.pt
D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics*; D010597:Pharmacogenetics; D012084:Renin-Angiotensin System / Q000187:drug effects
D000959:Antihypertensive Agents