title: Macrophage scavenger receptor 1 999C>T (R293X) mutation and risk of prostate cancer.
abstract: BACKGROUND
  Variants in the gene encoding the macrophage scavenger receptor 1 (MSR1(4)) protein have been identified in men with prostate cancer, and several small studies have suggested that the 999C>T (R293X) protein-truncating mutation may be associated with an increased risk for this disease.
  
  
  METHODS
  Using large case-control, cohort, and prostate cancer family studies conducted in several Western countries, we tested for the 999C>T mutation in 2,943 men with invasive prostate carcinoma, including 401 males from multiple-case families, 1,982 cases unselected for age, and 575 men diagnosed before the age of 56 years, and in 2,870 male controls. Risk ratios were estimated by unconditional logistic regression adjusting for country and by a modified segregation analysis. A meta-analysis was conducted pooling our data with published data.
  
  
  RESULTS
  The prevalence of MSR1*999C>T mutation carriers was 0.027 (SE, 0.003) in cases and 0.022 (SE, 0.002) in controls, and did not differ by country, ethnicity, or source. The adjusted risk ratio for prostate cancer associated with being a 999C>T carrier was 1.31 [95% confidence interval (CI), 0.93-1.84; P = 0.16]. The modified segregation analysis estimated the risk ratio to be 1.20 (95% CI, 0.87-1.66; P = 0.16). The risk ratio estimated from the meta-analysis was 1.34 (95% CI, 0.94-1.89; P = 0.10).
  
  
  CONCLUSIONS
  Our large-scale analysis of case and controls from several countries found no evidence that the 999C>T mutation is associated with increased risk of prostate cancer. The meta-analysis suggests it is unlikely that this mutation confers more than a 2-fold increased risk.
authors.affiliation: Translational Cancer Genetics Team, Section of Cancer Genetics and Urology Unit, Male Urological Centre and Institute of Cancer Research and Royal Marsden NHS Trust, Surrey, United Kingdom.
authors.forename: Questa
authors.initials: Q
authors.lastname: Hope
authors.forename: Sarah
authors.initials: S
authors.lastname: Bullock
authors.forename: Christopher
authors.initials: C
authors.lastname: Evans
authors.forename: Julia
authors.initials: J
authors.lastname: Meitz
authors.forename: Nancy
authors.initials: N
authors.lastname: Hamel
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Edwards
authors.forename: Gianluca
authors.initials: G
authors.lastname: Severi
authors.forename: David
authors.initials: D
authors.lastname: Dearnaley
authors.forename: Sameer
authors.initials: S
authors.lastname: Jhavar
authors.forename: Christine
authors.initials: C
authors.lastname: Southgate
authors.forename: Alison
authors.initials: A
authors.lastname: Falconer
authors.forename: Anna
authors.initials: A
authors.lastname: Dowe
authors.forename: Kenneth
authors.initials: K
authors.lastname: Muir
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
authors.forename: James C
authors.initials: JC
authors.lastname: Engert
authors.forename: David
authors.initials: D
authors.lastname: Roquis
authors.forename: Daniel
authors.initials: D
authors.lastname: Sinnett
authors.forename: Jacques
authors.initials: J
authors.lastname: Simard
authors.forename: Ketil
authors.initials: K
authors.lastname: Heimdal
authors.forename: Pål
authors.initials: P
authors.lastname: Møller
authors.forename: Lovise
authors.initials: L
authors.lastname: Maehle
authors.forename: Michael
authors.initials: M
authors.lastname: Badzioch
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Eeles
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.forename: Dallas R
authors.initials: DR
authors.lastname: English
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Southey
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.forename: William D
authors.initials: WD
authors.lastname: Foulkes
authors.forename: Graham G
authors.initials: GG
authors.lastname: Giles
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D051116:Receptors, Scavenger; D012307:Risk Factors; D051117:Scavenger Receptors, Class A
chemical_list: C495139:MSR1 protein, human; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A