title: Cell therapy for stroke.
abstract: Increasing experimental evidence suggests that cell transplantation can enhance recovery from stroke in animal models of focal cerebral ischemia. Clinical trials have been investigating the effects of a human immortalized neuronal cell line and porcine fetal neurons in stroke victims with persistent and stable deficits. Preclinical studies are focusing on the effects of human stem cells from various sources including brain, bone marrow, umbilical cord, and adipose tissue. This review presents an overview of preclinical and clinical studies on cell therapy for stroke. We emphasize the current, limited knowledge about the biology of implant sources and discuss special conditions in stroke that will impact the potential success of neurotransplantation in clinical trials.
authors.affiliation: Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. ssavitz@bidmc.harvard.edu
authors.forename: Sean I
authors.initials: SI
authors.lastname: Savitz
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Dinsmore
authors.forename: Lawrence R
authors.initials: LR
authors.lastname: Wechsler
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Rosenbaum
authors.forename: Louis R
authors.initials: LR
authors.lastname: Caplan
mesh_terms: D017690:Cell Transplantation; D002986:Clinical Trials as Topic; D006801:Humans; D009474:Neurons / Q000637:transplantation*; D020521:Stroke / Q000473:pathology / Q000628:therapy*
references.citation: J Cell Physiol. 2001 Oct;189(1):54-63
references.pmid: 11573204
references.citation: J Neurosci Res. 1999 Jun 15;56(6):581-94
references.pmid: 10374813
references.citation: J Neurol Sci. 2002 Jan 15;193(2):137-46
references.pmid: 11790394
references.citation: Am J Pathol. 2002 Apr;160(4):1201-6
references.pmid: 11943704
references.citation: Cell. 2002 Aug 23;110(4):429-41
references.pmid: 12202033
references.citation: Nat Med. 2002 Sep;8(9):963-70
references.pmid: 12161747
references.citation: Circulation. 2002 Sep 3;106(10):1294-9
references.pmid: 12208808
references.citation: Neuropathology. 2002 Dec;22(4):275-9
references.pmid: 12564767
references.citation: Circ Res. 2003 Apr 4;92(6):692-9
references.pmid: 12609969
references.citation: Nat Rev Neurosci. 2003 May;4(5):399-415
references.pmid: 12728267
references.citation: J Neurosci Res. 2003 Aug 1;73(3):296-307
references.pmid: 12868063
references.citation: J Neurosci Res. 2003 Sep 15;73(6):778-86
references.pmid: 12949903
references.citation: Stroke. 2003 Sep;34(9):2258-63
references.pmid: 12881607
references.citation: Exp Neurol. 2003 Oct;183(2):355-66
references.pmid: 14552877
references.citation: Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13632-7
references.pmid: 14581618
references.citation: Neurosurgery. 2004 Jan;54(1):150-5; discussion 155-6
references.pmid: 14683552
references.citation: J Neuropathol Exp Neurol. 2004 Jan;63(1):84-96
references.pmid: 14748564
references.citation: Neurology. 1983 Mar;33(3):345-50
references.pmid: 6681880
references.citation: Lab Invest. 1984 Feb;50(2):147-62
references.pmid: 6694356
references.citation: J Neurosci. 1992 May;12(5):1802-15
references.pmid: 1578271
references.citation: J Neurotrauma. 1992 Summer;9(2):107-12
references.pmid: 1404423
references.citation: Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2174-8
references.pmid: 7681588
references.citation: Exp Neurol. 1993 Aug;122(2):283-94
references.pmid: 8405265
references.citation: J Neurosci Res. 1993 Aug 15;35(6):585-602
references.pmid: 8411264
references.citation: Exp Neurol. 1994 Nov;130(1):151-67
references.pmid: 7821391
references.citation: J Cereb Blood Flow Metab. 1995 May;15(3):389-97
references.pmid: 7713996
references.citation: Lab Invest. 1995 Aug;73(2):273-83
references.pmid: 7637328
references.citation: J Comp Neurol. 1995 Jul 10;357(4):618-32
references.pmid: 7673487
references.citation: Neuroreport. 1999 Dec 16;10(18):3843-6
references.pmid: 10716220
references.citation: J Comp Neurol. 2000 Jul 3;422(3):380-95
references.pmid: 10861514
references.citation: Exp Neurol. 2000 Aug;164(2):247-56
references.pmid: 10915564
references.citation: J Neurosci Res. 2000 Aug 15;61(4):364-70
references.pmid: 10931522
references.citation: Exp Neurol. 1995 Aug;134(2):273-6
references.pmid: 7556547
references.citation: Nat Med. 1995 Nov;1(11):1189-94
references.pmid: 7584993
references.citation: J Cereb Blood Flow Metab. 2000 Sep;20(9):1311-9
references.pmid: 10994853
references.citation: Transplantation. 2000 Nov 15;70(9):1382-9
references.pmid: 11087157
references.citation: J Neurophysiol. 2000 Dec;84(6):2933-44
references.pmid: 11110822
references.citation: Yonsei Med J. 2000 Dec;41(6):825-35
references.pmid: 11204833
references.citation: Stroke. 2001 Apr;32(4):1005-11
references.pmid: 11283404
references.citation: Stroke. 2001 Apr;32(4):1012-9
references.pmid: 11283405
references.citation: Neurology. 2001 Jun 26;56(12):1666-72
references.pmid: 11425931
references.citation: Exp Neurol. 2001 Sep;171(1):109-15
references.pmid: 11520125
references.citation: Science. 1997 Apr 4;276(5309):71-4
references.pmid: 9082988
references.citation: Exp Neurol. 1998 Feb;149(2):310-21
references.pmid: 9500961
references.citation: J Comp Neurol. 1999 Apr 28;407(1):1-10
references.pmid: 10213184
references.citation: Stroke. 2001 Nov;32(11):2682-8
references.pmid: 11692034