Involvement of P1 adhesin in gliding motility of Mycoplasma pneumoniae as revealed by the inhibitory effects of antibody under optimized gliding conditions.
To examine the participation of P1 adhesin in gliding of Mycoplasma pneumoniae, we examined the effects of an anti-P1 monoclonal antibody on individual gliding mycoplasmas. The antibody reduced the gliding speed and removed the gliding cells from the glass over time in a concentration-dependent manner but had only a slight effect on nongliding cells, suggesting that the conformational changes of P1 adhesin and its displacement are involved in the gliding mechanism.
Seto
Shintaro
S
Department of Biology, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka 558-8585, Japan.
Kenri
Tsuyoshi
T
Tomiyama
Tetsuo
T
Miyata
Makoto
M
D018829:Adhesins, Bacterial / Q000502:physiology*; D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D001422:Bacterial Adhesion / Q000502:physiology; D009068:Movement; D009177:Mycoplasma pneumoniae / Q000502:physiology*; D013997:Time Factors
D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; C035471:adhesin, Mycoplasma pneumoniae
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