Hepatoprotective activity of the constituents in Swertia pseudochinensis.
A new xanthone derivative was isolated together with other 13 known constituents from a Chinese natural medicine, Swertia pseudochinensis HARA. Their structures were determined based on the spectral and chemical evidences. Furthermore, respective hexane, ethyl acetate, 1-BuOH, MeOH and water extracts of S. pseudochinensis, and purified compounds were respectively evaluated for their hepatoprotective activities against hepatocyte injury induced by CCl4. All the extracts and isolated compounds exhibited significant hepatoprotective activities at a dose showing no hepatoxicity.
Li
Jian-Chen
JC
Faculty of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi, Kumamoto, Japan. 028p9062@pharm.stud.kumamoto-u.ac.jp
Feng
Li
L
Sun
Bao-Hui
BH
Ikeda
Tsuyoshi
T
Nohara
Toshihiro
T
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D008107:Liver Diseases / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D035261:Plant Components, Aerial; D051381:Rats; D017208:Rats, Wistar; D029967:Swertia
D004365:Drugs, Chinese Herbal; D002251:Carbon Tetrachloride