title: Novel method for measurement of medium size arterial lumen area with an impedance catheter: in vivo validation.
abstract: There is no doubt that the transformation of a cardiac catheter into a conductance catheter that allows reliable and accurate assessment of lumen cross-sectional area (CSA) will provide a powerful diagnostic and treatment tool for the invasive cardiologist. The objective of this study was to develop a method based on the impedance catheter that allows accurate and reproducible measurements of CSA for medium size vessels (e.g., coronary, femoral, and carotid arteries). Two solutions of NaCl (0.5% and 1.5%) with known conductivities were injected directly into the lumen of the artery in eight swine. We showed that the CSA can be determined analytically from two Ohm's law-type algebraic equations that account for the parallel conductance of the current into the surrounding tissue. Excellent agreement was found between the conductance catheter with the proposed two-injection method and B-mode ultrasound (US). The root mean square error for the impedance measurements was 4.8% of the mean US diameter. The repeatability of the technique was assessed with duplicate measurements. The mean of the difference between the two measurements was nearly zero, and the repeatability coefficient was within 2.4% of the mean of the two measurements. The validated method was used to assess the degree of acute vasodilatation of the vessel in response to flow overload.
authors.affiliation: Dept. of Biomedical Engineering, University of California-Irvine, 204 Rockwell Engineering Center, Irvine, CA 92697-2715, USA. gkassab@uci.edu
authors.forename: Ghassan S
authors.initials: GS
authors.lastname: Kassab
authors.forename: Eugen R
authors.initials: ER
authors.lastname: Lontis
authors.forename: Arne
authors.initials: A
authors.lastname: Hørlyck
authors.forename: Hans
authors.initials: H
authors.lastname: Gregersen
mesh_terms: D000818:Animals; D001158:Arteries / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology*; D002339:Carotid Arteries / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology; D002404:Catheterization / Q000295:instrumentation / Q000379:methods* / Q000592:standards*; D003331:Coronary Vessels / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology; D017097:Electric Impedance; D005263:Femoral Artery / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D034421:Sus scrofa; D014463:Ultrasonography