title: CD5+ Epstein-Barr virus-positive intravascular large B-cell lymphoma in the uterus co-existing with huge myoma.
abstract: A 42-year-old female underwent hysterectomy because of a huge uterine mass. Histologically, she was diagnosed as having intravascular lymphoma co-existing with myoma uteri. Lymphoma cells were large in size and were positive for CD5, CD20, CD45, CD79a, lambda light chain, and EBV but were negative for CD3 and cyclin D1. No other organs except for the adjoining bilateral ovaries seemed to be affected by the lymphoma cells. She received the combination chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone) together with rituximab and has been well without definite disease progression. So far, this is the first case of CD5+ EBV+ intravascular large B-cell lymphoma (CD5+ EBV+ IVLBL) in the uterus of a patient who was incidentally diagnosed and successfully treated.
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Yamada
authors.forename: Ryo
authors.initials: R
authors.lastname: Uchida
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Fuchida
authors.forename: Akira
authors.initials: A
authors.lastname: Okano
authors.forename: Masashi
authors.initials: M
authors.lastname: Okamoto
authors.forename: Naoya
authors.initials: N
authors.lastname: Ochiai
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Iwasa
authors.forename: Chihiro
authors.initials: C
authors.lastname: Shimazaki
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018956:CD5 Antigens / Q000378:metabolism*; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D016393:Lymphoma, B-Cell / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008279:Magnetic Resonance Imaging; D012074:Remission Induction; D014594:Uterine Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000821:virology; D014599:Uterus / Q000098:blood supply / Q000473:pathology* / Q000821:virology; D019043:Vascular Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology* / Q000821:virology
chemical_list: D018956:CD5 Antigens