Effect of acute hyperinsulinemia on ventricular repolarization in uncomplicated obesity.
BACKGROUND
Acute hyperinsulinemia has been shown to increase QTc interval in lean subjects, but data on obese subjects are still unclear. Aim of this study was to evaluate the effect of acute hyperinsulinemia on QTc interval and QTc dispersion in uncomplicated obesity.


METHODS
We calculated QTc duration and QTc dispersion in 30 uncomplicated obese subjects (mean age 32.2 +/- 7, BMI 36.7 +/- 9.4 kg/m(2)) by measurements of 12-lead ECG recording during a euglycemic hyperinsulinemic clamp.


RESULTS
Insulin infusion during the clamp did not significantly modify QTc interval and QTc dispersion in uncomplicated obese subjects (401.5 +/- 29.2 vs. 413.7 +/- 30.5; 35.4 +/- 10.5 vs. 38.7 +/- 14.5, respectively).


CONCLUSIONS
Acute hyperinsulinemia seems to no significantly affect ventricular repolarization in uncomplicated obesity. Insulin resistance and the absence of diabetes and hypertension could explain, at least in part, this finding.
Iacobellis
Gianluca
G
Curione
Mario
M
Di Bona
Simonetta
S
Ribaudo
Maria Cristina
MC
Zappaterreno
Alessandra
A
Vecci
Elio
E
Di Mario
Umberto
U
Leonetti
Frida
F
D000208:Acute Disease; D000328:Adult; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000503:physiopathology*; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D016276:Ventricular Function