title: Relief of reflux symptoms after endoscopic gastroplication may be associated with reduced esophageal Acid sensitivity: a pilot study.
abstract: OBJECTIVE
  Although the new endoscopic techniques for the treatment of gastroesophageal reflux disease (GERD) lead to marked clinical benefit, the underlying mechanism of this is unknown.
  
  
  METHODS
  In this prospective study, the effect of endoscopic gastroplication was investigated in six patients with GERD, who were assessed before and 4 weeks after treatment. The effect on reflux symptoms, quality of life, proton pump inhibitor (PPI) consumption, reflux esophagitis, acid exposure, esophageal motility, lower esophageal sphincter pressure (LESP), and gastric emptying was measured. Esophageal acid sensitivity before and after treatment was investigated using a standardized acid provocation test, and compared with that of six age- and sex-matched healthy controls.
  
  
  RESULTS
  Significant clinical benefit and discontinuation of PPI consumption after gastroplication was seen. Among the objectively measured parameters, only acid exposure was significantly reduced and gastric emptying significantly delayed. However, acid exposure remained pathologically high. Esophageal acid sensitivity was significantly reduced. The induction of heartburn and/or pain was abolished in four patients after gastroplication. In two patients the intensity of heartburn/pain was significantly reduced by 40 % or 60 %, and the time to provoke heartburn/pain significantly prolonged by 40% or 100%.
  
  
  CONCLUSIONS
  These preliminary data suggest that the decrease of esophageal sensitivity to acid after endoscopic gastroplication is part of the mechanism responsible for the reduction of reflux symptoms.
authors.affiliation: Department of Internal Medicine (Med. Klinik II), Klinikum Krefeld, Lutherplatz 40, 47805 Krefeld, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Wenzel
authors.forename: R
authors.initials: R
authors.lastname: Kuhlbusch
authors.forename: J
authors.initials: J
authors.lastname: Heise
authors.forename: T
authors.initials: T
authors.lastname: Frieling
mesh_terms: D000328:Adult; D004947:Esophagus; D005260:Female; D018662:Fundoplication / Q000379:methods*; D005744:Gastric Acid / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D005773:Gastroscopy; D006356:Heartburn / Q000209:etiology / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D016896:Treatment Outcome