[Therapeutic effects of rhEPO, rhG-CSF on sulfur mustard induced toxicity in dogs].
OBJECTIVE
To evaluate the therapeutic effects of recombinant human erythropoietin (rhEPO) and recombinant human granulocyte colony stimulating factor (rhG-CSF) on sulfur mustard (SM) induced toxicity in dogs.


METHODS
Ten dogs were used as the animal model. Control group had four dogs while treatment group had six. Half an hour after subcutaneously injected with 12 mg/kg (body weight) of SM, the dogs of the treatment group were treated by rhEPO, rhG-CSF and other medicines. General examinations of blood were measured before injecting SM and were continually watched for a week after poisoning.


RESULTS
Three dogs in control group died in three days after poisoning, dogs in treatment group all survived. WBC of the control group decreased significantly 3 days after poisoning. RBC of the control group had a slight increase at first, then came down. While WBC and RBC of treatment group remained constant. LYM of both groups descended notably right after poisoning, especially in control group. Two days after poisoning, RC in treatment group began to rise and remained at high level for about a week. No obvious changes of RC in control group were found.


CONCLUSIONS
The use of rhEPO and rhG-CSF after SM exposure can stimulate the growth of the erythrocyte, reticulocyte and leucocyte in dogs. Therefore, rhEPO and rhG-CSF may be significant assistant drugs in future experiment of SM.
Cai
Yun
Y
Department of Chemical Defence Medicine, Faculty of Naval Medicine, Shanghai 200433, China.
Ma
Qian
Q
Zhang
Liming
L
Zhao
Jie
J
Zhu
Mingxue
M
Hu
Weijiang
W
Jiang
Pengliang
P
Yuan
Wei
W
D000818:Animals; D001772:Blood Cell Count; D004195:Disease Models, Animal; D004285:Dogs; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000627:therapeutic use*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D009151:Mustard Gas / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor; D009151:Mustard Gas