title: Specificity of postsynaptic excitations of different sensory modality in neurons of edible snail during learning.
abstract: The development of sensitization in edible snails during intracellular injection of oligonucleotides specifically inhibiting C/EBP transcription factors results in selective suppression of synaptic facilitation in responses of LPl1 neurons evoked by chemical stimulation of the head. At the same time, facilitation of the responses to tactile stimulation of the head or foot developed as in control sensitized animals. The data are interpreted from the viewpoint of P. K. Anokhin hypothesis that integrative function of cerebral neurons involved in construction of biologic functional systems is based on peculiar pre- and postsynaptic chemical processes selectively projected onto the genome of neural cell.
authors.affiliation: P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. shevelkin@mtu-net.ru
authors.forename: V P
authors.initials: VP
authors.lastname: Nikitin
authors.forename: K V
authors.initials: KV
authors.lastname: Sudakov
authors.forename: V V
authors.initials: VV
authors.lastname: Sherstnev
mesh_terms: D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics / Q000502:physiology; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology*; D006372:Helix, Snails / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D011803:Quinine / Q000494:pharmacology
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D011803:Quinine