A side effect of neuraminidase inhibitor in a patient with liver cirrhosis.
Neuraminidase inhibitors have been widely used in Japan since 2001, and several side-effects of their use have been reported. However, erythema toxicum has rarely been described as a side-effect of these drugs in patients with liver function disorder. Here, we report a case of generalized rash after treatment with the neuraminidase inhibitors zanamivir and oseltamivir administered prophylactically to prevent influenza infection in two patients with hepatoma associated with liver cirrhosis.
Kaji
Masahide
M
Department of Internal Medicine, Kurume University Medical Center, 155-1 Kokubumachi, Kurume, 839-0863, Japan. mkaji@ktarn.or.jp
Fukuda
Takaaki
T
Tanaka
Masatoshi
M
Aizawa
Hisamichi
H
D000081:Acetamides / Q000009:adverse effects*; D000368:Aged; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D004791:Enzyme Inhibitors / Q000009:adverse effects*; D005260:Female; D006146:Guanidines; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy*; D008297:Male; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D053139:Oseltamivir; D011714:Pyrans; D012794:Sialic Acids / Q000009:adverse effects*; D053243:Zanamivir
D000081:Acetamides; D004791:Enzyme Inhibitors; D006146:Guanidines; D011714:Pyrans; D012794:Sialic Acids; D053139:Oseltamivir; D009439:Neuraminidase; D053243:Zanamivir