title: FADD adaptor in cancer.
abstract: FADD (Fas Associated protein with Death Domain) is a key adaptor molecule transmitting the death signal mediated by death receptors. In addition, this multiple functional protein is implicated in survival/proliferation and cell cycle progression. FADD functions are regulated via cellular sublocalization, protein phosphorylation, and inhibitory molecules. In the present review, we focus on the role of the FADD adaptor in cancer. Increasing evidence shows that defects in FADD protein expression are associated with tumor progression both in mice and humans. Better knowledge of the mechanisms leading to regulation of FADD functions will improve understanding of tumor growth and the immune escape mechanisms, and could open a new field for therapeutic interventions.
authors.affiliation: Département d'Immunologie, Institut Cochin, INSERM U 567, CNRS UMR 8104, IFR 116, Université René Descartes, Paris V, Paris, France. chiocchia@cochin.inserm.fr.
authors.forename: Léa
authors.initials: L
authors.lastname: Tourneur
authors.forename: Agnès
authors.initials: A
authors.lastname: Buzyn
authors.forename: Gilles
authors.initials: G
authors.lastname: Chiocchia
references.citation: Nat Med. 2000 Aug;6(8):920-3
references.pmid: 10932231
references.citation: Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10488-92
references.pmid: 7937980
references.citation: Nature. 1997 Jul 10;388(6638):190-5
references.pmid: 9217161
references.citation: Blood. 1997 Dec 15;90(12):4901-9
references.pmid: 9389707
references.citation: J Clin Endocrinol Metab. 1999 Aug;84(8):2924-32
references.pmid: 10443700
references.citation: Cell. 1995 May 19;81(4):505-12
references.pmid: 7538907
references.citation: Mol Cell Biol. 1996 Jun;16(6):2756-63
references.pmid: 8649383
references.citation: Science. 1998 Mar 20;279(5358):1954-8
references.pmid: 9506948
references.citation: J Immunol. 2003 Jul 1;171(1):247-56
references.pmid: 12817005
references.citation: Cancer Res. 2004 Nov 1;64(21):8101-8
references.pmid: 15520222
references.citation: Oncogene. 2003 May 8;22(18):2795-804
references.pmid: 12743602
references.citation: Nat Med. 1996 Dec;2(12):1361-6
references.pmid: 8946836
references.citation: J Clin Invest. 1997 Mar 15;99(6):1173-8
references.pmid: 9077524
references.citation: Cell Death Differ. 2003 Jul;10(7):791-7
references.pmid: 12815462
references.citation: Nature. 1992 Mar 26;356(6367):314-7
references.pmid: 1372394
references.citation: Nat Med. 2000 May;6(5):493-5
references.pmid: 10802692
references.citation: Immunity. 2003 Apr;18(4):513-21
references.pmid: 12705854
references.citation: Mod Pathol. 1998 Apr;11(4):369-75
references.pmid: 9578088
references.citation: Carcinogenesis. 2004 Jul;25(7):1089-97
references.pmid: 15001534
references.citation: Nature. 1997 Apr 3;386(6624):517-21
references.pmid: 9087414
references.citation: Cell. 1997 Feb 7;88(3):355-65
references.pmid: 9039262
references.citation: J Immunol. 2000 May 15;164(10):5023-7
references.pmid: 10799856
references.citation: J Immunol. 1996 Dec 15;157(12):5461-6
references.pmid: 8955195
references.citation: Nat Immunol. 2003 May;4(5):404-9
references.pmid: 12719729
references.citation: J Biol Chem. 2000 Aug 18;275(33):25065-8
references.pmid: 10862756
references.citation: Int J Biochem Cell Biol. 1999 May;31(5):533-7
references.pmid: 10399313
references.citation: J Biol Chem. 1998 Feb 20;273(8):4345-9
references.pmid: 9468483
references.citation: Curr Biol. 2001 Feb 20;11(4):273-6
references.pmid: 11250157
references.citation: J Exp Med. 1996 Sep 1;184(3):1075-82
references.pmid: 9064324
references.citation: Trends Biochem Sci. 2001 Aug;26(8):475-81
references.pmid: 11504623
references.citation: Int J Cancer. 2003 Jul 10;105(5):593-600
references.pmid: 12740905
references.citation: Cancer Res. 1997 Mar 15;57(6):1007-12
references.pmid: 9067260
references.citation: EMBO J. 1998 Feb 2;17(3):706-18
references.pmid: 9450996
references.citation: Nat Genet. 1995 Nov;11(3):294-300
references.pmid: 7581453
references.citation: EMBO J. 2000 Mar 1;19(5):931-41
references.pmid: 10698935
references.citation: EMBO J. 1995 Nov 15;14(22):5579-88
references.pmid: 8521815
references.citation: Cell. 1996 Jun 14;85(6):817-27
references.pmid: 8681377
references.citation: Nat Med. 2001 Mar;7(3):259
references.pmid: 11231598
references.citation: J Cell Biol. 1998 Jun 1;141(5):1243-53
references.pmid: 9606215
references.citation: Science. 1996 Nov 22;274(5291):1363-6
references.pmid: 8910274
references.citation: Proc Natl Acad Sci U S A. 2001 May 22;98(11):6307-12
references.pmid: 11353862
references.citation: J Immunother Emphasis Tumor Immunol. 1993 Oct;14(3):234-41
references.pmid: 7507710
references.citation: Cell. 2003 Jul 25;114(2):181-90
references.pmid: 12887920
references.citation: J Biol Chem. 1999 Mar 19;274(12):7987-92
references.pmid: 10075697
references.citation: J Invest Dermatol. 1997 Feb;108(2):215-9
references.pmid: 9008237
references.citation: Int J Oncol. 2003 Jun;22(6):1375-81
references.pmid: 12739008
references.citation: Nature. 1998 Mar 19;392(6673):296-300
references.pmid: 9521326
references.citation: Blood. 2001 Aug 15;98(4):913-24
references.pmid: 11493433
references.citation: Proc Natl Acad Sci U S A. 2001 Nov 20;98 (24):13884-8
references.pmid: 11717445
references.citation: Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8104-9
references.pmid: 10393955
references.citation: Blood. 2000 Dec 1;96(12):3900-6
references.pmid: 11090076
references.citation: J Biol Chem. 2001 Dec 7;276(49):46639-46
references.pmid: 11583996
references.citation: J Biol Chem. 2001 Aug 10;276(32):29815-8
references.pmid: 11390402
references.citation: J Biol Chem. 2003 Oct 24;278(43):41585-8
references.pmid: 12954630
references.citation: Leukemia. 1999 Nov;13(11):1854-8
references.pmid: 10557062
references.citation: Nat Med. 2001 Jun;7(6):680-6
references.pmid: 11385504
references.citation: Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5211-6
references.pmid: 12702765
references.citation: J Natl Cancer Inst. 1997 Jun 4;89(11):783-9
references.pmid: 9182976
references.citation: Blood. 1999 Nov 1;94(9):3135-40
references.pmid: 10556200
references.citation: Nature. 1998 Apr 30;392(6679):941-5
references.pmid: 9582077
references.citation: J Immunol. 2000 Feb 1;164(3):1236-42
references.pmid: 10640736