Diabetes mellitus and the risk of prostate cancer in Italy.
OBJECTIVE
We investigated the relation between diabetes and the risk of prostate cancer, as epidemiological results are controversial.


METHODS
A hospital-based case-control study was conducted in Italy between 1991 and 2002. Cases were 1294 men, aged <75 years, with incident histologically confirmed prostate cancer, and controls were 1451 men, aged <75 years, admitted to hospital for acute non-neoplastic diseases. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression models.


RESULTS
No material association between diabetes and prostate cancer was observed, with a multivariate OR of 1.02 (95%CI 0.75-1.40). Prostate cancer was not related to time since diagnosis of diabetes (OR 0.82 and 0.97 for <5 and >/=15 years since diagnosis respectively). The OR were respectively 1.63 (95%CI 0.70-3.81) and 0.96 (95%CI 0.68-1.34) in men diagnosed with diabetes at age <45 or >/=45 years. The risk estimates were similar across strata of age at interview, body mass index and, among cases, of Gleason score.


CONCLUSIONS
This study shows no material association between diabetes and prostate cancer risk.
Tavani
A
A
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy. tavani@marionegri.it
Gallus
S
S
Bertuzzi
M
M
Dal Maso
L
L
Zucchetto
A
A
Negri
E
E
Franceschi
S
S
Ramazzotti
V
V
Montella
M
M
La Vecchia
C
C
D017677:Age Distribution; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors