Subthalamic stimulation activates internal pallidus: evidence from cGMP microdialysis in PD patients.
Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.
Stefani
Alessandro
A
Instituto di Ricovero e Cura a Carrattere Scientificio (IRCCS) Fondazione Santa Lucia, Via Ardeatina 306, 00179 Rome, Italy.
Fedele
Ernesto
E
Galati
Salvatore
S
Pepicelli
Olimpia
O
Frasca
Stefania
S
Pierantozzi
Mariangela
M
Peppe
Antonella
A
Brusa
Livia
L
Orlacchio
Antonio
A
Hainsworth
Atticus H
AH
Gattoni
Giuseppe
G
Stanzione
Paolo
P
Bernardi
Giorgio
G
Raiteri
Maurizio
M
Mazzone
Paolo
P
D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D006152:Cyclic GMP / Q000378:metabolism*; D046690:Deep Brain Stimulation / Q000379:methods*; D003956:Dialysis / Q000379:methods; D005260:Female; D005917:Globus Pallidus / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000528:radiation effects*
D006152:Cyclic GMP