title: Constituents of Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activity.
abstract: A new sesquiterpene 2,9-humuladien-6-ol-8-one (1) was isolated from methanol extract of Zingiber aromaticum, along with 15 known compounds. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses. The isolated compounds were tested for their inhibitory activity on the metabolism mediated by cytochrome P450 3A4 (CYP3A4) and CYP2D6.
authors.affiliation: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.lastname: Subehan
authors.forename: Tepy
authors.initials: T
authors.lastname: Usia
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kadota
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tezuka
mesh_terms: D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism*; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000432:Methanol / Q000737:chemistry; D008862:Microsomes, Liver / Q000201:enzymology; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012996:Solutions / Q000737:chemistry; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: C502854:2,9-humuladien-6-ol-8-one; D004791:Enzyme Inhibitors; D012717:Sesquiterpenes; D012996:Solutions; D003577:Cytochrome P-450 Enzyme System; C104464:CYP3A protein, human; D019389:Cytochrome P-450 CYP2D6; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D000432:Methanol