Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells.
The molecular effects of Saussurea lappa extracts, a traditional medicine in Eastern Asia, on the fate of gastric carcinoma have not been understood. In this study, its cytostatic effects were examined using gastric AGS cancer cells. Its treatment resulted in apoptosis and G2-arrest in a dose- and time-dependent manner. The effects were attributed to the regulation of cyclins and pro-apoptotic molecules and suppression of anti-apoptotic molecules. Therefore, these results suggest that extracts of S. lappa root may be a candidate to deal with gastric cancers either by traditional herbal therapy or by combinational therapy with conventional chemotherapy.
Ko
Seong Gyu
SG
Cancer Research Institute, Department of Tumor Biology, College of Medicine, Seoul National University, Seoul 110-799, South Korea.
Kim
Hwang-Phill
HP
Jin
Dong-Hoon
DH
Bae
Hyun-Su
HS
Kim
Sung Hoon
SH
Park
Chong-Hyeong
CH
Lee
Jung Weon
JW
D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D030441:Saussurea / Q000737:chemistry*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000187:drug effects
D010936:Plant Extracts; D016159:Tumor Suppressor Protein p53