Synergistic killing of Streptococcus pneumoniae with the bacteriophage lytic enzyme Cpl-1 and penicillin or gentamicin depends on the level of penicillin resistance.
A combination of Cpl-1, a bacteriophage lytic enzyme, and penicillin, gentamicin, levofloxacin, or azithromycin was tested against Streptococcus pneumoniae strains with various susceptibilities to penicillin. Activities of Cpl-1 and gentamicin were increasingly synergistic with a decreasing penicillin MIC, while Cpl-1 and penicillin showed synergy against an extremely penicillin-resistant strain.
Djurkovic
Svetolik
S
Laboratory of Bacterial Pathogenesis, The Rockefeller University, 1230 York Ave., New York, NY 10021, USA.
Loeffler
Jutta M
JM
Fischetti
Vincent A
VA
D004357:Drug Synergism; D005839:Gentamicins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000494:pharmacology*; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D005839:Gentamicins; D010406:Penicillins; D009238:N-Acetylmuramoyl-L-alanine Amidase
J Infect Dis. 2000 Oct;182(4):1153-60
10979912
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4107-12
11259652
Science. 2001 Dec 7;294(5549):2170-2
11739958
Microb Drug Resist. 2001 Winter;7(4):303-16
11822770
Nature. 2002 Aug 22;418(6900):884-9
12192412
Microb Drug Resist. 1997 Summer;3(2):165-76
9185145
Antimicrob Agents Chemother. 2003 Jan;47(1):375-7
12499217
Infect Immun. 2003 Nov;71(11):6199-204
14573637
J Antimicrob Chemother. 2003 Dec;52(6):967-73
14613958
J Infect Dis. 1985 Aug;152(2):365-72
2863313
Antimicrob Agents Chemother. 2003 Jan;47(1):144-7
12499182