Re-analysis of 34 full-length HIV-1 intersubtype recombinant sequences.
One of the main characteristics of the HIV-1 is its extensive genetic heterogeneity. Intersubtype recombination was first described in 1995 and since then a significant proportion of the HIV-1 isolates was found to comprise mosaic sequences. Re-analysis of 34 full-length HIV-1 intersubtype recombinants, including all "pure" HIV-1 subtypes revealed that 19 of the 34 analyzed mosaics consist of a more complex mosaic pattern than initially described. These findings indicate that the complexity of the HIV-1 recombinants is much greater than previously estimated.
Magiorkinis
G
G
National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Mikras Asias 75, 11527 Athens, Greece.
Paraskevis
D
D
Magiorkinis
E
E
Vandamme
A-M
AM
Hatzakis
A
A
D014644:Genetic Variation; D015497:HIV-1 / Q000235:genetics*; D010802:Phylogeny; D011995:Recombination, Genetic; D016415:Sequence Alignment / Q000379:methods; D017421:Sequence Analysis / Q000379:methods; D012984:Software