title: DNA mixtures: biostatistics for mixed stains with haplotypic genetic markers.
abstract: The conventional theory for interpreting forensic DNA evidence developed for the autosomal genetic markers is not applicable in the case of haplotypic markers, specifically for Y-STR based data. The reason is, that in contrast to the case of autosomal markers, single alleles found in the mixed stain cannot be assigned to unknown stain contributors independently of each other, while the assignable entities are sets of linked alleles which should be treated as non-separable units. It is shown that the conventional theory cannot be extended to this situation. A novel theory which accounts for the features of haplotypic markers has been developed within the general framework of the hypotheses testing approach. This theory opens the way for the use of haplotypic markers in the analysis of mixed stains with the arbitrary numbers of unknown contributors and linked loci. A numerical example demonstrates the application of the theory.
authors.affiliation: Birkenstrasse 4B, 79256 Buchenbach, Germany. lefu@ruf.uni-freiburg.de
authors.forename: N
authors.initials: N
authors.lastname: Fukshansky
authors.forename: W
authors.initials: W
authors.lastname: Bär
mesh_terms: D000483:Alleles; D001826:Body Fluids / Q000737:chemistry; D041322:Chromosomes, Human, Y; D004247:DNA / Q000032:analysis; D016172:DNA Fingerprinting; D005554:Forensic Medicine; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D015233:Models, Statistical; D011336:Probability; D020080:Tandem Repeat Sequences
chemical_list: D005819:Genetic Markers; D004247:DNA
references.citation: Mol Biol Evol. 1998 Sep;15(9):1108-14
references.pmid: 9729875
references.citation: Int J Legal Med. 1998;112(1):15-21
references.pmid: 9932736
references.citation: Int J Legal Med. 2003 Oct;117(5):306-11
references.pmid: 12904973
references.citation: Forensic Sci Int. 2001 May 15;118(2-3):105-81
references.pmid: 11430274
references.citation: Int J Legal Med. 2002 Jun;116(3):133-8
references.pmid: 12111315
references.citation: Int J Legal Med. 1998;111(2):62-6
references.pmid: 9541852
references.citation: Int J Legal Med. 2000;114(1-2):78-82
references.pmid: 11197634
references.citation: J Forensic Sci. 2002 May;47(3):513-9
references.pmid: 12051329
references.citation: Forensic Sci Int. 2000 Oct 9;114(1):31-43
references.pmid: 10924848
references.citation: Forensic Sci Int. 2003 Jul 8;134(2-3):172-9
references.pmid: 12850414
references.citation: Int J Legal Med. 1997;110(3):118-24
references.pmid: 9228562
references.citation: Biol Chem. 1997 Aug;378(8):923-7
references.pmid: 9377490
references.citation: J Forensic Sci. 1997 Mar;42(2):213-22
references.pmid: 9068179
references.citation: Int J Legal Med. 2001;114(6):305-9
references.pmid: 11508794
references.citation: Am J Hum Genet. 2000 Dec;67(6):1526-43
references.pmid: 11078479
references.citation: Int J Legal Med. 1999;112(6):383-7
references.pmid: 10550600
references.citation: Int J Legal Med. 1996;109(4):186-94
references.pmid: 9007634
references.citation: Forensic Sci Int. 2001 May 15;118(2-3):106-13
references.pmid: 11311820
references.citation: Int J Legal Med. 1996;109(4):195-204
references.pmid: 9007635
references.citation: Int J Legal Med. 1998;112(1):1
references.pmid: 9932733
references.citation: Forensic Sci Int. 1999 Jun 28;102(2-3):159-65
references.pmid: 10464931