Anxiolytic effects of intra-amygdaloid injection of the D1 antagonist SCH23390 in the rat.
The intercalated islands are intra-amigdaloid clusters of D1 receptor rich GABAergic neurons, which control impulse traffic between the basolateral complex and the central nucleus of the amygdala. As dopaminergic transmission within the amygdala may play a role in anxiety, the effect of the D1 antagonist SCH23390 microinjected mainly close to the rostral intercalated islands in rats was studied, using the White and Black Box test. SCH23390 reduced anxiety by an increase in the latency of the first entry into the black compartment and by an increase in the total time spent in the white compartment of the White and Black Box test, while there was no significant modification of locomotion. It is suggested that blockade of D1 receptors in the rostral intercalated islands may reduce anxiety through a reduction of GABA-mediated dishinibition of the central amygdaloid nucleus.
de la Mora
Miguel Pérez
MP
Department of Biophysics, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-253, 04510 México, D.F., México. mperez@ifc.unam.mx
Cárdenas-Cachón
Linda
L
Vázquez-García
Mariana
M
Crespo-Ramírez
Minerva
M
Jacobsen
Kirsten
K
Höistad
Malin
M
Agnati
Luigi
L
Fuxe
Kjell
K
D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001552:Benzazepines / Q000008:administration & dosage*; D018492:Dopamine Antagonists / Q000008:administration & dosage*; D007276:Injections, Intraventricular; D008124:Locomotion / Q000187:drug effects / Q000502:physiology; D008297:Male; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors* / Q000502:physiology
D014151:Anti-Anxiety Agents; D001552:Benzazepines; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1