The impact of nanobiotechnology on the development of new drug delivery systems.
Nanotechnology, or systems/devices manufactured at the molecular level, is a multidisciplinary scientific field undergoing explosive development. A part of this field is the development of nanoscaled drug delivery devices. Nanoparticles have been developed as an important strategy to deliver conventional drugs, recombinant proteins, vaccines and more recently nucleotides. Nanoparticles and other colloidal drug delivery systems modify the kinetics, body distribution and drug release of an associated drug. Other effects are tissue or cell specific targeting of drugs and the reduction of unwanted side effects by a controlled release. Therefore nanoparticles in the pharmaceutical biotechnology sector improve the therapeutic index and provide solutions for future delivery problems for new classes of so called biotech drugs including recombinant proteins and oligonucleotides. This review discusses nanoparticular drug carrier systems with the exception of liposomes used today, and what the potential and limitations of nanoparticles in the field of pharmaceutical biotechnology are.
Kayser
O
O
University of Groningen, Groningen University Institute of Drug Exploration, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. o.kayser@farm.rug.nl
Lemke
A
A
Hernández-Trejo
N
N
D000818:Animals; D001709:Biotechnology / Q000379:methods* / Q000639:trends*; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends*; D006801:Humans; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods* / Q000639:trends*