Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia.
Myelodysplastic syndromes (MDS) are comprised of a heterogeneous group of stem cell disorders characterized by ineffective hematopoiesis and susceptibility to transform to acute myeloid leukemia. The molecular pathways underlying disease initiation and evolution are still largely unknown. We recently demonstrated that acquired mutations in PTPN11 are a major event in JMML and occur with variable prevalence in children with other hematologic malignancies, including MDS. Here, we investigated contribution of PTPN11 mutations to adult MDS and CMML pathogenesis. Our results indicate that PTPN11 lesions might play a role in adult MDS/CMML pathogenesis but do not represent a major molecular event.
Loh
Mignon L
ML
Department of Pediatrics, University of California, San Francisco, CA, USA.
Martinelli
Simone
S
Cordeddu
Viviana
V
Reynolds
Melissa G
MG
Vattikuti
Shashaank
S
Lee
Connie M
CM
Wulfert
Michael
M
Germing
Ulrich
U
Haas
Peter
P
Niemeyer
Charlotte
C
Beran
Miloslav E
ME
Strom
Sara
S
Lübbert
Michael
M
Sorcini
Mariella
M
Estey
Elihu H
EH
Gattermann
Norbert
N
Tartaglia
Marco
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*
D047908:Intracellular Signaling Peptides and Proteins; C516724:PTPN11 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases