Massive myeloid sarcoma affecting the central nervous system, mediastinum, retroperitoneum, liver, and rectum associated with acute myeloblastic leukaemia: a case report.
Myeloid sarcomas are extramedullary tumours with granulocytic precursors. When associated with acute myelogenous leukaemia (AML), these tumours usually affect no more than two different extramedullary regions. This report describes a myeloid sarcoma associated with AML with tumour formation at five anatomical sites. The patient was a 37 year old man admitted in September 1999 with a two month history of weight loss, symptoms of anaemia, rectal bleeding, and left facial nerve palsy. The anatomical sites affected were: the rectum, the right lobe of the liver, the mediastinum, the retroperitoneum, and the central nervous system. A bone marrow smear was compatible with AML M2. Flow cytometry showed that the peripheral blood was positive for CD4, CD11, CD13, CD14, CD33, CD45, and HLA-DR. A karyotypic study of the bone marrow revealed an 8;21 translocation. The presence of multiple solid tumours in AML is a rare event. Enhanced expression of cell adhesion molecules may be the reason why some patients develop myeloid sarcomas.
Best-Aguilera
C R
CR
Departmento de Hematologia, Hospital General de Occidente, SSJ, Zapopan, Jalisco, 45170 México. bestvme@cencar.udg.mx
Vazquez-Del Mercado
M
M
Muñoz-Valle
J F
JF
Herrera-Zarate
L
L
Navarro-Hernandez
R E
RE
Martin-Marquez
B T
BT
Oregon-Romero
E
E
Ruiz-Quezada
S
S
Bonilla
G M
GM
Lomeli-Guerrero
A
A
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D023981:Sarcoma, Myeloid / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
Leuk Res. 2001 Nov;25(11):1019-21
11597737
Blood. 2002 Oct 1;100(7):2292-302
12239137
An Med Interna. 2003 Mar;20(3):141-4
12756900
Cancer. 1973 Apr;31(4):948-55
4513297
J Am Acad Dermatol. 1997 Aug;37(2 Pt 2):308-11
9270534
Br J Haematol. 1984 Feb;56(2):199-213
6197988
Am J Surg Pathol. 1993 Oct;17(10):1011-9
8372941
Ann Intern Med. 1995 Sep 1;123(5):351-3
7625623
Cancer. 1981 Sep 15;48(6):1426-37
7023656