[Studies on the system for the exclusive control substance in traditional Chinese herbal medicines].
OBJECTIVE
To establish the system for the exclusive control substance of plant drug (CSPD) in traditional Chinese herbal medicines (TCHM) for the purpose of original identification.


METHODS
Three kinds of representative TCHMs were selected and their exclusive CSPDs were obtained by standardized procedure. The expression of the total chemical characteristic of the CSPDs were achieved with the comparative analysis of the 1H-NMR spectra for the CSPDs of the samples of the same species collected from different regions as well as the isolation and elucidation of the chemical constituents.


RESULTS
The 1H-NMR spectra of the CSPDs for three kinds of representative TCHMs have highly characteristic features and reproducibility, and showed mainly the resonance signals of the characteristic constituents of each species. These 1H-NMR spectra were strictly correlative with the origin of the species.


CONCLUSIONS
By using the procedure of this paper, the exclusive CSPDs can be obtained for most of TCHMs, which have important significance and can be regarded as references in the original identification of TCHMs.
Qin
Hai-lin
HL
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. qinhailin@imm.ac.cn
Li
Zhi-hong
ZH
Wang
Peng
P
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D039323:Coptis / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D030004:Ligusticum / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D031363:Scutellaria / Q000737:chemistry; D013045:Species Specificity
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007783:Lactones