Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin.
Chemerin is a chemotactic agent that was recently identified as the ligand of ChemR23, a serpentine receptor expressed by activated macrophages and monocyte-derived dendritic cells (DCs). This paper shows that blood plasmacytoid and myeloid DCs express functional ChemR23. Recombinant chemerin induced the transmigration of plasmacytoid and myeloid DCs across an endothelial cell monolayer. In secondary lymphoid organs (lymph nodes and tonsils), ChemR23 is expressed by CD123(+) plasmacytoid DCs and by CD1a(+) DC-SIGN(+) DCs in the interfollicular T cell area. ChemR23(+) DCs were also observed in dermis from normal skin, whereas Langerhans cells were negative. Chemerin expression was selectively detected on the luminal side of high endothelial venules in secondary lymphoid organs and in dermal endothelial vessels of lupus erythematosus skin lesions. Chemerin(+) endothelial cells were surrounded by ChemR23(+) plasmacytoid DCs. Thus, ChemR23 is expressed and functional in plasmacytoid DCs, a property shared only by CXCR4 among chemotactic receptors. This finding, together with the selective expression of the cognate ligand on the luminal side of high endothelial venules and inflamed endothelium, suggests a key role of the ChemR23/chemerin axis in directing plasmacytoid DC trafficking.
Vermi
William
W
Department of Pathology, University of Brescia, 25123 Brescia, Italy.
Riboldi
Elena
E
Wittamer
Valerie
V
Gentili
Francesca
F
Luini
Walter
W
Marrelli
Simona
S
Vecchi
Annunciata
A
Franssen
Jean-Denis
JD
Communi
David
D
Massardi
Luisa
L
Sironi
Marina
M
Mantovani
Alberto
A
Parmentier
Marc
M
Facchetti
Fabio
F
Sozzani
Silvano
S
D002465:Cell Movement; D002478:Cells, Cultured; D018925:Chemokines / Q000096:biosynthesis / Q000494:pharmacology; D002630:Chemotactic Factors / Q000096:biosynthesis / Q000494:pharmacology; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology* / Q000473:pathology; D008221:Lymphoid Tissue / Q000098:blood supply* / Q000276:immunology / Q000378:metabolism; D022423:Myeloid Cells / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology; D019707:Receptors, Chemokine / Q000096:biosynthesis / Q000502:physiology*; D012867:Skin / Q000098:blood supply* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D014699:Venules / Q000276:immunology / Q000378:metabolism
C102741:CMKLR1 protein, human; D018925:Chemokines; D002630:Chemotactic Factors; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; C478630:RARRES2 protein, human; D019707:Receptors, Chemokine
Am J Pathol. 1999 Feb;154(2):385-94
10027397
J Invest Dermatol. 1997 Jul;109(1):91-5
9204961
J Cell Biochem. 1999 Sep 15;74(4):587-95
10440928
Annu Rev Immunol. 2000;18:767-811
10837075
J Immunol. 2000 Dec 1;165(11):6037-46
11086035
J Exp Med. 2000 Dec 18;192(12):F39-44
11120782
Nat Immunol. 2000 Oct;1(4):353-7
11017109
J Immunol. 2001 Aug 15;167(4):1862-6
11489962
J Leukoc Biol. 2002 Mar;71(3):445-57
11867682
Nat Rev Immunol. 2002 Mar;2(3):151-61
11913066
Curr Opin Immunol. 2002 Jun;14(3):373-9
11973137
J Exp Med. 2002 Aug 19;196(4):417-30
12186835
Trends Immunol. 2002 Nov;23(11):549-55
12401408
J Immunol. 2002 Dec 1;169(11):6079-83
12444109
J Invest Dermatol. 2002 Nov;119(5):1096-102
12445198
Annu Rev Immunol. 2003;21:685-711
12615891
J Pathol. 2003 Jun;200(2):255-68
12754747
J Exp Med. 2003 Sep 1;198(5):823-30
12953097
J Exp Med. 2003 Oct 6;198(7):977-85
14530373
Virchows Arch. 2003 Dec;443(6):703-17
14586652
Nat Rev Immunol. 2003 Nov;3(11):867-78
14668803
J Biol Chem. 2004 Mar 12;279(11):9956-62
14701797
Am J Pathol. 2004 May;164(5):1587-95
15111305
Nat Rev Immunol. 2004 May;4(5):360-70
15122201
Immunity. 2004 May;20(5):539-50
15142523
Thromb Haemost. 1987 Apr 7;57(2):176-82
3496680
Arteriosclerosis. 1987 Jul-Aug;7(4):389-400
3300618
J Invest Dermatol. 1992 Dec;99(6):683-90
1361507
Microvasc Res. 1996 Nov;52(3):221-34
8954864
Nat Med. 1999 Aug;5(8):919-23
10426316