title: Gene expression in spermiogenesis.
abstract: Germ cells convey parental genes to the next generation, and only germ cells perform meiosis, which is a mechanism that preserves the parental genes. The fusion of the products of germ cell meiosis, the haploid sperm and egg, creates the next generation. Sperm are the haploid germ cells that contribute genes to the egg. In preparation for this, the haploid round spermatids produced by meiosis undergo drastic morphological changes to become sperm. During this process of spermiogenesis, the nuclear form of the haploid germ cell takes shape, the mitochondria are rearranged in a specific manner, the flagellum develops and the acrosome forms. Spermatogenesis is supported by precise and orderly regulation of gene expression during the changes in chromatin structure, when protamine replaces histone. In this report, we summarize the molecular mechanisms involved in spermiogenesis.
authors.affiliation: Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita City 565-0871, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Baba
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D015870:Gene Expression / Q000502:physiology*; D006801:Humans; D008297:Male; D008745:Methylation; D013091:Spermatogenesis / Q000235:genetics*; D013737:Testis / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin
references.citation: Circulation. 2006 Apr 11;113(14):1807-16
references.pmid: 16567565
references.citation: Neuromuscul Disord. 2008 Jan;18(1):34-44
references.pmid: 17897828
references.citation: Acta Neuropathol. 2009 Mar;117(3):293-307
references.pmid: 19151983
references.citation: Europace. 2000 Jan;2(1):4-14
references.pmid: 11225594
references.citation: Biochem J. 2011 May 15;436(1):113-21
references.pmid: 21361873
references.citation: Eur Heart J. 2008 Jan;29(2):270-6
references.pmid: 17916581
references.citation: J Am Coll Cardiol. 2011 Aug 23;58(9):925-34
references.pmid: 21851881
references.citation: J Am Coll Cardiol. 2008 Oct 7;52(15):1250-60
references.pmid: 18926329
references.citation: Br Heart J. 1972 Jun;34(6):545-52
references.pmid: 4402697
references.citation: Eur J Pediatr. 2014 Feb;173(2):239-42
references.pmid: 23989969
references.citation: Acta Neuropathol. 2013 Jan;125(1):47-75
references.pmid: 23143191
references.citation: Herz. 2009 Feb;34(1):55-62
references.pmid: 19214409
references.citation: J Am Coll Cardiol. 2012 Jan 31;59(5):493-500
references.pmid: 22281253
references.citation: Glob Heart. 2013 Dec;8(4):355-82
references.pmid: 25690638
references.citation: Curr Opin Rheumatol. 1996 Nov;8(6):528-38
references.pmid: 9018456
references.citation: Semin Pediatr Neurol. 2002 Jun;9(2):100-7
references.pmid: 12138994
references.citation: Br Heart J. 1980 Dec;44(6):672-3
references.pmid: 7459150
references.citation: Circulation. 2013 Jan 1;127(1):126-40
references.pmid: 23283857
references.citation: Neuromuscul Disord. 2013 Jan;23(1):4-14
references.pmid: 23116935
references.citation: Circulation. 1956 Feb;13(2):217-23
references.pmid: 13356381
references.citation: Lancet. 1957 Dec 14;273(7007):1179-84
references.pmid: 13492602
references.citation: Orphanet J Rare Dis. 2013 Feb 14;8:26
references.pmid: 23406536
references.citation: J Electrocardiol. 2005 Oct;38(4 Suppl):81-7
references.pmid: 16226080