title: Effects of parsley (Petroselinum crispum) on the liver of diabetic rats: a morphological and biochemical study.
abstract: Parsley is used by diabetics in Turkey to reduce blood glucose. The present study aims to investigate both the morphological and biochemical effects of parsley on liver tissue. Rat hepatocytes were examined by light and electron microscopy. Degenerative changes were observed in the hepatocytes of diabetic rats. These degenerative changes were significantly reduced or absent in the hepatocytes of diabetic rats treated with parsley. Blood glucose levels, alanine transaminase and alkaline phosphatase were observed to be raised in diabetic rats. Diabetic rats treated with parsley demonstrated significantly lower levels of blood glucose, alanine transaminase and alkaline phosphatase. The present study suggests that parsley demonstrates a significant hepatoprotective effect in diabetic rats.
authors.affiliation: Department of Biology, Faculty of Science, Istanbul University, 34459-Vezneciler, Istanbul, Turkey. sbolkent@superonline.com
authors.forename: S
authors.initials: S
authors.lastname: Bolkent
authors.forename: R
authors.initials: R
authors.lastname: Yanardag
authors.forename: O
authors.initials: O
authors.lastname: Ozsoy-Sacan
authors.forename: O
authors.initials: O
authors.lastname: Karabulut-Bulan
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control; D022781:Hepatocytes / Q000187:drug effects / Q000648:ultrastructure; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D028528:Petroselinum; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase