Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility.
Meade
Maureen O
MO
Department of Medicine and Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada. meadema@HHSC.CA
D001291:Attitude of Health Personnel; D006801:Humans; D018447:Medical Futility; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic