title: Lack of association between hepatitis B virus infection and polymorphism of mannose-binding lectin gene in Korean population.
abstract: Mannose-binding lectin (MBL) plays an important role in immune defense. This study was undertaken to investigate the association between hepatitis B virus infection and polymorphisms of MBL gene. We assessed the single nucleotide polymorphism at codon 54 in exon 1 of MBL in patients with hepatitis B virus infection and HBsAg negative controls in Korean population. A total of 498 enrolled subjects was classified into four groups. Group 1; Clearance, Group 2; Inactive healthy carrier, Group 3; Chronic hepatitis, Group 4; Liver cirrhosis. MBL gene polymorphisms at codon 54 led to three genotypes (G/G, G/A, A/A). When we divided subjects into clearance group (group 1) and persistence group (group 2-4), G/G genotype and A-allele carrier were observed in 55.6% and 44.4% in clearance group, 64.8% and 35.2% in persistence group (p=0.081), respectively. When hepatitis B virus persistent cases were divided into inactive healthy carrier (group 2) and disease progression group (group 3 and 4), MBL gene polymorphisms at codon 54 were not related to disease progression (p=0.166). MBL gene polymorphism at codon 54 was not associated with the clearance of hepatitis B virus infection nor progression of disease in chronic hepatitis B virus infection.
authors.affiliation: Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Jae Youn
authors.initials: JY
authors.lastname: Cheong
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Cho
authors.forename: Sun Kyo
authors.initials: SK
authors.lastname: Lim
authors.forename: Do Hyun
authors.initials: DH
authors.lastname: Shin
authors.forename: Seung Kew
authors.initials: SK
authors.lastname: Yoon
authors.forename: Jong Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Ki Baik
authors.initials: KB
authors.lastname: Hahm
authors.forename: Jin Hong
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000328:Adult; D000483:Alleles; D003062:Codon; D018450:Disease Progression; D005260:Female; D005355:Fibrosis; D005838:Genotype; D006505:Hepatitis; D006509:Hepatitis B / Q000235:genetics* / Q000378:metabolism*; D006515:Hepatitis B virus / Q000378:metabolism*; D006579:Heterozygote; D006801:Humans; D007723:Korea; D037102:Lectins; D008297:Male; D037601:Mannose-Binding Lectin / Q000737:chemistry* / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
chemical_list: D003062:Codon; D037102:Lectins; D037601:Mannose-Binding Lectin
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