title: Analysis of antiepileptic drugs in biological fluids by means of electrokinetic chromatography.
abstract: An overview of the electrokinetic chromatographic methods for the analysis of antiepileptic drug levels in biological samples is presented. In particular, micellar electrokinetic capillary chromatography is a very suitable method for the determination of these drugs, because it allows a rapid, selective, and accurate analysis. In addition to the electrokinetic chromatographic studies on the determination of antiepileptic drugs, some information regarding sample pretreatment will also be reported: this is a critical step when the analysis of biological fluids is concerned. The electrokinetic chromatographic methods for the determination of recent antiepileptic drugs (e.g., lamotrigine, levetiracetam) and classical anticonvulsants (e.g., carbamazepine, phenytoin, ethosuximide, valproic acid) will be discussed in depth, and their pharmacological profiles will be briefly described as well.
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Pucci
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
authors.forename: Maria Augusta
authors.initials: MA
authors.lastname: Raggi
mesh_terms: D000086:Acetazolamide / Q000032:analysis; D000927:Anticonvulsants / Q000032:analysis* / Q000097:blood / Q000652:urine; D001463:Barbiturates / Q000032:analysis; D001569:Benzodiazepines / Q000032:analysis; D002220:Carbamazepine / Q000032:analysis; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D000078328:Felbamate; D006801:Humans; D006827:Hydantoins / Q000032:analysis; D007555:Isoxazoles / Q000032:analysis; D000077213:Lamotrigine; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000032:analysis; D013388:Succinimides / Q000032:analysis; D014227:Triazines / Q000032:analysis; D014635:Valproic Acid / Q000032:analysis; D020888:Vigabatrin / Q000032:analysis; D000078305:Zonisamide
chemical_list: D000927:Anticonvulsants; D001463:Barbiturates; D006827:Hydantoins; D007555:Isoxazoles; D048448:Phenylcarbamates; D011409:Propylene Glycols; D013388:Succinimides; D014227:Triazines; D001569:Benzodiazepines; D002220:Carbamazepine; D000078305:Zonisamide; D014635:Valproic Acid; D020888:Vigabatrin; D000086:Acetazolamide; D000077213:Lamotrigine; D000078328:Felbamate
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