Marine actinomycetes as a source of novel secondary metabolites.
A set of 600 actinomycetes strains which were isolated from marine sediments from various sites in the Pacific and Atlantic Oceans were screened for the production of bioactive secondary metabolites. Marine streptomycete strains were found to be producers of well known chemically diverse antibiotics isolated from terrestrial streptomycetes, as in the case of marine Micromonospora strains. New marine members of the rare genus Verrucosispora seem to be a promising source for novel bioactive secondary metabolites as shown in the case of the abyssomicin producing strain AB-18-032.
Fiedler
Hans-Peter
HP
Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany. hans-peter.fiedler@uni-tuebingen.de
Bruntner
Christina
C
Bull
Alan T
AT
Ward
Alan C
AC
Goodfellow
Michael
M
Potterat
Olivier
O
Puder
Carsten
C
Mihm
Gerhard
G
D000192:Actinomycetales / Q000145:classification / Q000254:growth & development / Q000302:isolation & purification* / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification*; D001267:Atlantic Ocean; D003470:Culture Media / Q000737:chemistry; D019015:Geologic Sediments / Q000382:microbiology*; D008848:Micromonosporaceae / Q000145:classification / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism; D015394:Molecular Structure; D010140:Pacific Ocean; D012623:Seawater
D000900:Anti-Bacterial Agents; D003470:Culture Media