title: Comparative clinical and ultrasound study of egg-negative and egg-positive individuals from Schistosoma mansoni low morbidity endemic areas, and hospitalized patients with hepatosplenic disease.
abstract: Two hundred and twenty three subjects from a Schistosoma mansoni low morbidity endemic area and nine hospitalized hepatosplenic patients were submitted to stool test and clinical examination and abdomen ultrasound assessments. According to stool examination and ultrasound results, they were grouped as follows: G1 -- 63 Schistosoma mansoni egg-negative individuals; G2 -- 141 egg-positive patients and without evidence of periportal fibrosis; G3 -- 19 egg-positive patients with periportal echogenicity (3-6 mm); and G4 -- 9 hepatosplenic patients with periportal echogenicity (> 6 mm). Hepatomegaly detected by physical examination of the abdomen evaluated in the midclavicular line was verified in G1, G2 and G3, respectively, in 11.1, 12.1 and 26.3%. In G1, G2 and G3, periportal thickening occurred only in schistosomal patients (8.5%). Mild pathological alterations in patients that cannot yet be detected by clinical examination were detectable in the liver by ultrasound and can be due to fibrosis. The degree of mild periportal fibrosis was diminished in 57.9% of patients 12 months after treatment of schistosomiasis with oxamniquine. At ultrasonography, the mean liver left lobe measurement of G3 was larger than that of G1, and that of G4 larger than that of G1 and G2. The mean size of the spleen of G4 was significantly larger than that of the other three groups, and that of G3 larger than that of G1 and G2.
authors.affiliation: Santa Casa Hospital de Belo Horizonte, MG, Belo Horizonte, MG, Brazil.
authors.forename: Telcia V B
authors.initials: TV
authors.lastname: Magalhães
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gazzinelli
authors.forename: Maria Carolina B
authors.initials: MC
authors.lastname: Alvarez
authors.forename: F C
authors.initials: FC
authors.lastname: Lima e Silva
authors.forename: Lucia Alves Oliveira
authors.initials: LA
authors.lastname: Fraga
authors.forename: Alda Maria S
authors.initials: AM
authors.lastname: Silveira
authors.forename: Andrea
authors.initials: A
authors.lastname: Gazzinelli
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Bethony
authors.forename: Philip
authors.initials: P
authors.lastname: LoVerde
authors.forename: Iramaya R
authors.initials: IR
authors.lastname: Caldas
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Correa-Oliveira
authors.forename: Aluízio
authors.initials: A
authors.lastname: Prata
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D016022:Case-Control Studies; D002648:Child; D019353:Endemic Diseases; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000469:parasitology; D008109:Liver Diseases, Parasitic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010073:Oxamniquine / Q000627:therapeutic use; D010270:Parasite Egg Count; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000469:parasitology; D012555:Schistosomiasis mansoni / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D012556:Schistosomicides / Q000627:therapeutic use; D012720:Severity of Illness Index; D013158:Splenic Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D014463:Ultrasonography
chemical_list: D012556:Schistosomicides; D010073:Oxamniquine