title: Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene.
abstract: Mutations that inactivate the retinoblastoma (Rb) pathway are common in human tumors. Such mutations promote tumor growth by deregulating the G1 cell cycle checkpoint. However, uncontrolled cell cycle progression can also produce new liabilities for cell survival. To uncover such liabilities in Rb mutant cells, we performed a clonal screen in the Drosophila eye to identify second-site mutations that eliminate Rbf(-) cells, but allow Rbf(+) cells to survive. Here we report the identification of a mutation in a novel highly conserved peptidyl prolyl isomerase (PPIase) that selectively eliminates Rbf(-) cells from the Drosophila eye.
authors.affiliation: Exelixis, South San Francisco, California 94083, USA.
authors.forename: Kyle A
authors.initials: KA
authors.lastname: Edgar
authors.forename: Marcia
authors.initials: M
authors.lastname: Belvin
authors.forename: Annette L
authors.initials: AL
authors.lastname: Parks
authors.forename: Kellie
authors.initials: K
authors.lastname: Whittaker
authors.forename: Matt B
authors.initials: MB
authors.lastname: Mahoney
authors.forename: Monique
authors.initials: M
authors.lastname: Nicoll
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Park
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Winter
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Kim
authors.initials: K
authors.lastname: Lickteig
authors.forename: Ferhad
authors.initials: F
authors.lastname: Ahmad
authors.forename: Hanife
authors.initials: H
authors.lastname: Esengil
authors.forename: Matthew V
authors.initials: MV
authors.lastname: Lorenzi
authors.forename: Amanda
authors.initials: A
authors.lastname: Norton
authors.forename: Brent A
authors.initials: BA
authors.lastname: Rupnow
authors.forename: Laleh
authors.initials: L
authors.lastname: Shayesteh
authors.forename: Mariano
authors.initials: M
authors.lastname: Tabios
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Young
authors.forename: Pamela M
authors.initials: PM
authors.lastname: Carroll
authors.forename: Casey
authors.initials: C
authors.lastname: Kopczynski
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Plowman
authors.forename: Lori S
authors.initials: LS
authors.lastname: Friedman
authors.forename: Helen L
authors.initials: HL
authors.lastname: Francis-Lang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004331:Drosophila melanogaster / Q000196:embryology* / Q000201:enzymology / Q000235:genetics; D005123:Eye / Q000196:embryology* / Q000201:enzymology; D008969:Molecular Sequence Data; D009154:Mutation; D019696:Peptidylprolyl Isomerase / Q000235:genetics*; D016160:Retinoblastoma Protein / Q000235:genetics*
chemical_list: D016160:Retinoblastoma Protein; D019696:Peptidylprolyl Isomerase
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