Synthesis and characterization of a carboranyl-tetrabenzoporphyrin.
An expeditious synthetic route to a carboranyl-substituted tetrabenzoporphyrin is reported. The absorption and emission spectra of water-soluble tetrabenzoporphyrin 4 are distinct from those of a known carboranylporphyrin (5). Both tetrabenzoporphyrin 4 and porphyrin 5 were found to be non-toxic toward V79 hamster lung fibroblast cells at 300 microM, using an MTT assay. The X-ray structure of a Cu(II)-carboranyl-tetrabenzoporphyrin is presented and discussed.
Ongayi
Owendi
O
Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
Gottumukkala
Vijay
V
Fronczek
Frank R
FR
Vicente
M Graça H
MG
D000818:Animals; D016754:Boron Neutron Capture Therapy; D002460:Cell Line; D006224:Cricetinae; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology; D011166:Porphyrins / Q000138:chemical synthesis* / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
D017319:Photosensitizing Agents; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents