title: Comparison of pulsatile with nonpulsatile mechanical support in a porcine model of profound cardiogenic shock.
abstract: The aim of this study was to examine whether pulsatility by intraaortic balloon counterpulsation (IABP) is an important adjunct to the treatment of profound cardiogenic shock (CS) with a widely used, nonpulsatile centrifugal pump (CP). In each of 18 anesthetized, open chest pigs, the outflow cannula of the CP was inserted in the aortic arch through the right external carotid artery, and the inflow cannula of the CP was placed in the left atrium. A 40 cc IABP was subsequently placed in the descending aorta through the left external carotid artery. CS was induced by occlusion of coronary arteries and the infusion of propranolol and crystalloid fluid. Mean aortic pressure, pulse pressure, aortic end diastolic pressure, left ventricular end diastolic pressure, right atrial pressure, and heart rate were monitored. Cardiac output and left anterior descending artery flow were measured with a transit time ultrasound flowmeter. During profound CS, life sustaining hemodynamics were maintained only with the support of the assist devices. Hemodynamic support with the CP was associated with a nearly nonpulsatile flow and a pulse pressure of 7 +/- 4 mm Hg, which increased to 33 +/- 10 mm Hg (p = 0.000) after combining the CP with the IABP. Compared with the hemodynamic support offered by the CP alone, addition of the IABP increased mean aortic pressure from 40 +/- 15 to 50 +/- 16 mm Hg (p = 0.000), cardiac output from 810 +/- 194 to 1,200 +/- 234 ml/min (p = 0.003), and left anterior descending artery flow from 26 +/- 10 to 39 +/- 14 ml/min (p = 0.001). In profound CS, mechanical support provided by a continuous flow CP is enhanced by the added pulsatility of the IABP.
authors.affiliation: University of Athens School of Medicine, Department of Clinical Therapeutics, "Alexandra" Hospital, Athens, Greece.
authors.forename: Stavros G
authors.initials: SG
authors.lastname: Drakos
authors.forename: Christos E
authors.initials: CE
authors.lastname: Charitos
authors.forename: Argirios
authors.initials: A
authors.lastname: Ntalianis
authors.forename: John V
authors.initials: JV
authors.lastname: Terrovitis
authors.forename: Kostas X
authors.initials: KX
authors.lastname: Siafakas
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Dolou
authors.forename: Charalampos
authors.initials: C
authors.lastname: Pierrakos
authors.forename: Efstratios
authors.initials: E
authors.lastname: Charitos
authors.forename: John
authors.initials: J
authors.lastname: Karelas
authors.forename: John N
authors.initials: JN
authors.lastname: Nanas
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology; D001794:Blood Pressure; D002404:Catheterization; D015908:Counterpulsation; D003971:Diastole; D004195:Disease Models, Animal; D006339:Heart Rate; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology*; D007423:Intra-Aortic Balloon Pumping; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology*; D012770:Shock, Cardiogenic / Q000139:chemically induced / Q000628:therapy*; D034421:Sus scrofa