Two new cytotoxic linderazulenes from a deep-sea gorgonian of the genus Paramuricea.
The known compound linderazulene (1) and two new linderazulenes (2, 3) were isolated from a deep-sea gorgonian Paramuricea sp. The structures of 2 and 3 were determined through spectroscopic methods. Compounds 1-3 show moderate in vitro cytotoxicity against the P388 murine leukemia cell line with IC(50)'s of 18.8, 2.7, and 15.6 microg/mL, respectively. Compound 2 showed moderate activity against the PANC-1 pancreatic cell line with an IC(50) of 18.7 microg/mL.
Reddy
N Srinivasa
NS
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, FL 34946, USA.
Reed
John K
JK
Longley
Ross E
RE
Wright
Amy E
AE
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D052176:Azulenes; D045744:Cell Line, Tumor; D003063:Cnidaria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
C499031:11-carbomethoxylinderazulene; C499032:11-formyllinderazulene; D000970:Antineoplastic Agents; D052176:Azulenes; D005663:Furans; C499030:linderazulene