Synthesis of substituted quinolines by electrophilic cyclization of N-(2-alkynyl)anilines.
Quinolines substituted in the 3-position by an iodo or phenylseleno group are readily prepared in good to excellent yields by the reaction of propargylic anilines with appropriate electrophiles under mild reaction conditions. [reaction: see text]
Zhang
Xiaoxia
X
Department of Chemistry, Iowa State University, Ames, IA 50011, USA.
Campo
Marino A
MA
Yao
Tuanli
T
Larock
Richard C
RC
D000480:Alkynes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D011804:Quinolines / Q000032:analysis / Q000138:chemical synthesis*
D000480:Alkynes; D000814:Aniline Compounds; D011804:Quinolines