title: Does antiphospholipid antibody syndrome affect bioprosthetic heart valve? Midterm echocardiographic report.
abstract: Cardiovascular involvements in antiphospholipid antibody syndrome have been recognized as a major complication of this disease. Furthermore, some papers report bioprosthetic heart valve also seems to be affected. A 32-year-old female with aortic regurgitation presented to our hospital. Further examination revealed high titer of anticardiolipin beta 2 glycoprotein 1 antibody, and she was diagnosed as having primary antiphospholipid antibody syndrome since the patient failed to match the criteria of systemic lupus erythematosus. Cardiopulmonary bypass was uneventfully conducted under systemic heparinization of usual dosage. Administration of warfarin sodium was started on the third postoperative day, and international normalized ratio was controlled from 2.0 to 2.5. On echocardiographic examination at 1 month, mean systolic gradient was 17 mmHg. Although transesophageal echocardiography at 2 years after surgery revealed no sign of valvular destruction or sclerosis, transaortic gradient had increased to 26 mmHg. Bioprosthetic stenosis was suspected probably due to pannus formation and the patient may have to undergo another valve replacement in the near future.
authors.affiliation: Department of Cardiovascular Surgery, Nagoya National Hospital, Nagoya, Japan.
authors.forename: Shunei
authors.initials: S
authors.lastname: Saito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikeguchi
authors.forename: Harumitsu
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Koike
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Eiji
authors.initials: E
authors.lastname: Takeuchi
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000209:etiology; D001705:Bioprosthesis; D002315:Cardiopulmonary Bypass; D004452:Echocardiography; D017548:Echocardiography, Transesophageal; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology
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