title: A reentry study on the use of bovine porous bone mineral, GTR, and platelet-rich plasma in the regenerative treatment of intrabony defects in humans.
abstract: This study compared the clinical effectiveness of a combination therapy consisting of bovine porous bone mineral (BPBM), guided tissue regeneration (GTR), and platelet-rich plasma (PRP) in the regeneration of periodontal intrabony defects in humans. Twenty-eight paired intrabony defects were surgically treated using a split-mouth design. Defects were treated with BPBM, GTR, and PRP (experimental), or with open-flap debridement (control). Clinical parameters evaluated included changes in attachment level, pocket depth, and defect fill as revealed by reentry at 6 months. Preoperative pocket depths, attachment levels, and transoperative bone measurements were similar for the two groups. Postsurgical measurements taken at 6 months revealed that both treatment modalities significantly decreased pocket depth and increased clinical attachment and defect fill compared to baseline. The differences between the experimental and control groups were 2.22+/-0.39 mm on buccal and 2.12+/-0.34 mm on lingual sites for pocket depth, 3.05+/-0.51 mm on buccal and 2.88+/-0.46 mm on lingual sites for gain in clinical attachment, and 3.46+/-0.96 mm on buccal and 3.42+/-0.02 mm on lingual sites for defect fill. These differences between groups were statistically significant in favor of the experimental defects. The combined therapy was also clinically more effective than open-flap debridement. The superiority of the experimental group could not be attributed solely to the surgical intervention and was likely a result of the BPBM/GTR/ PRP application. Combining BPBM, GTR, and PRP was an effective modality of regenerative treatment for intrabony defects in patients with advanced periodontitis.
authors.affiliation: School of Dentistry, University of California, Los Angeles 90095, USA. pauloc@dentnet.dent.ucla.edu
authors.forename: Paulo M
authors.initials: PM
authors.lastname: Camargo
authors.forename: Vojislav
authors.initials: V
authors.lastname: Lekovic
authors.forename: Michael
authors.initials: M
authors.lastname: Weinlaender
authors.forename: Nikola
authors.initials: N
authors.lastname: Vasilic
authors.forename: Milovan
authors.initials: M
authors.lastname: Madzarevic
authors.forename: E Barrie
authors.initials: EB
authors.lastname: Kenney
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D000818:Animals; D001792:Blood Platelets; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods; D002417:Cattle; D003094:Collagen; D003131:Combined Modality Therapy; D005260:Female; D006133:Growth Substances / Q000008:administration & dosage; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008903:Minerals; D010514:Periodontal Pocket / Q000601:surgery; D010956:Plasmapheresis; D024162:Second-Look Surgery
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D018786:Bone Substitutes; D006133:Growth Substances; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen