title: Cellular organization by self-organization: mechanisms and models for Min protein dynamics.
abstract: We use the oscillating Min proteins of Escherichia coli as a prototype system to illustrate the current state and potential of modeling protein dynamics in space and time. We demonstrate how a theoretical approach has led to striking new insights into the mechanisms of self-organization in bacterial cells and indicate how these ideas may be applicable to more complex structure formation in eukaryotic cells.
authors.affiliation: Department of Mathematics, Imperial College London, London SW7 2AZ, England, UK. karsten@mpipks-dresden.mpg.de
authors.forename: Martin
authors.initials: M
authors.lastname: Howard
authors.forename: Karsten
authors.initials: K
authors.lastname: Kruse
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D001683:Biological Clocks / Q000502:physiology*; D018797:Cell Cycle Proteins; D002455:Cell Division / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D004926:Escherichia coli / Q000166:cytology / Q000502:physiology; D029968:Escherichia coli Proteins / Q000378:metabolism*; D008954:Models, Biological; D011485:Protein Binding
chemical_list: D018797:Cell Cycle Proteins; D029968:Escherichia coli Proteins; C093548:MinE protein, E coli; D000251:Adenosine Triphosphatases; C072069:MinD protein, E coli
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