Hazard functions and expected spike density functions for neuron spike activity in the cochlear nucleus of the cat.
The goal of these experiments was to evaluate the effect of stimulus evoked input and post spike refractoriness on the shapes of post stimulus time histograms (PSTHs). The time courses of spontaneous and/or evoked activity were studied in 153 neurons located predominantly in the dorsal cochlear nucleus in cats anesthetized with Nembutal. Tone bursts were presented to the ipsilateral ear in a free sound field. About half the cells were characterized by the pauser/build-up type of PSTH. Marked refractoriness was evidenced by relatively long recovery times of the hazard functions of spontaneous and tone-evoked spike activity. On presentation of tonal bursts, the time dependence of the probability of the first spike in the absence of a preceding spike (expected spike density function) was greater than the PSTH (actual spike density function). The initial PSTH peak with pause was shaped primarily by stimulus evoked input, whereas refractoriness tended to diminish the build-up portion of the PSTH. In chopper cells, PSTH peaks were usually not reflected in expected spike density functions showing that post spike refractoriness plays a major role in shaping the PSTH. In primary-like cells, refractoriness was small and had little effect on the shape of the PSTH. Some presumptively inhibitory cells showed a tendency to burst discharges with non-monotonic hazard functions. A very small number of cells showed a tendency to internal tuning to a defined signal periodicity.
Bibikov
N
N
The N. N. Andreev Acoustic Institute, 117036 Moscow, Russia.
Imig
T
T
Samson
F
F
D000161:Acoustic Stimulation / Q000379:methods; D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002415:Cats; D017626:Cochlear Nucleus / Q000166:cytology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors
J Neurophysiol. 1976 Mar;39(2):282-300
1255224
Exp Brain Res. 1973 Jun 29;17(4):402-27
4725899
Trends Neurosci. 2000 May;23(5):216-22
10782127
J Neurophysiol. 1978 Sep;41(5):1165-82
212537
J Comp Neurol. 1994 Oct 8;348(2):261-76
7814691
J Neurophysiol. 2002 May;87(5):2505-19
11976387
Exp Brain Res. 1983;52(3):333-55
6653696
J Neurophysiol. 1994 Mar;71(3):914-30
8201432
J Comp Neurol. 1975 Jul 15;162(2):269-84
1150922
J Neurophysiol. 1985 Oct;54(4):917-39
4067627
J Neurophysiol. 1999 Dec;82(6):3434-57
10601474
J Neurophysiol. 1993 May;69(5):1409-21
8389823
J Neurophysiol. 1993 May;69(5):1384-97
8389821
J Neurophysiol. 1992 May;67(5):1247-63
1597710
J Neurophysiol. 1987 Feb;57(2):414-42
3559686
Brain Res. 1978 Jun 9;148(1):43-65
656932
J Neurophysiol. 2000 Feb;83(2):907-25
10669504
J Neurosci. 1998 May 15;18(10):3955-66
9570822
Exp Neurol. 1980 Sep;69(3):576-88
7409065
J Neurophysiol. 1982 Sep;48(3):856-73
6290620
Biophys J. 1967 Nov;7(6):759-77
19210997
J Acoust Soc Am. 1995 Apr;97(4):2405-13
7714258
Hear Res. 2000 Nov;149(1-2):216-22
11033260
J Neurophysiol. 1990 Nov;64(5):1590-610
2283542
J Physiol. 1988 Feb;396:535-48
2457693
J Neurosci. 1990 Jul;10(7):2338-51
2376777
Hear Res. 1990 Apr;45(1-2):95-113
2345121
Biofizika. 2001 May-Jun;46(3):545-56
11449559
J Comp Neurol. 1983 Feb 1;213(4):426-47
6300199
J Neurophysiol. 1997 May;77(5):2549-72
9163376
Biofizika. 1975 Sep-Oct;20(5):887-92
1203277
Exp Brain Res. 1975 Oct 24;23(4):367-86
1183510
Exp Brain Res. 1966;1(3):220-35
5920550
J Neurophysiol. 1988 Jul;60(1):1-29
3404211
Exp Neurol. 1972 Oct;37(1):131-51
5077556
J Neurophysiol. 1989 Dec;62(6):1303-29
2600627
J Neurophysiol. 2002 May;87(5):2520-30
11976388
J Neurophysiol. 1995 Feb;73(2):550-61
7760117
J Neurophysiol. 1986 Aug;56(2):287-307
3760922
Ann Biomed Eng. 1998 May-Jun;26(3):473-87
9570230
J Neurophysiol. 1980 Jul;44(1):76-96
7420140
J Neurophysiol. 1996 Sep;76(3):1667-88
8890284
Hear Res. 1992 Jul;60(2):115-42
1639723