title: Cerebral and conjunctival haemorrhages associated with von Willebrand factor deficiency and canine angiostrongylosis.
abstract: A case of angiostrongylosis is described in a 14-month-old golden retriever bitch. Conjunctival haemorrhage and neurological signs, referable to a space-occupying cerebral lesion, were associated with defective primary haemostasis caused by low levels of von Willebrand factor. Full clinical recovery followed treatment with desmopressin, fresh whole blood transfusion, fenbendazole and supportive care. The magnetic resonance image of the suspected organising haematoma is described. Similarities to the human condition, acquired von Willebrand syndrome, and a possible role for aberrant larval migration in haematoma formation are suggested.
authors.affiliation: Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, Hitchin, Hertfordshire.
authors.forename: N T
authors.initials: NT
authors.lastname: Whitley
authors.forename: N
authors.initials: N
authors.lastname: Corzo-Menendez
authors.forename: N G
authors.initials: NG
authors.lastname: Carmichael
authors.forename: J W
authors.initials: JW
authors.lastname: McGarry
mesh_terms: D000801:Angiostrongylus; D000818:Animals; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000662:veterinary; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004285:Dogs; D005130:Eye Hemorrhage / Q000209:etiology / Q000662:veterinary; D005260:Female; D017206:Strongylida Infections / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D014057:Tomography, X-Ray Computed / Q000662:veterinary; D014842:von Willebrand Diseases / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*