Directed evolution of an amine oxidase for the preparative deracemisation of cyclic secondary amines.
Carr
Reuben
R
School of Chemistry, The University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, Scotland, UK.
Alexeeva
Marina
M
Dawson
Michael J
MJ
Gotor-Fernández
Vicente
V
Humphrey
Cara E
CE
Turner
Nicholas J
NJ
D000588:Amines / Q000737:chemistry / Q000378:metabolism*; D019943:Amino Acid Substitution / Q000235:genetics; D001234:Aspergillus niger / Q000201:enzymology*; D020134:Catalytic Domain / Q000235:genetics; D019020:Directed Molecular Evolution; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D008995:Monoamine Oxidase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010293:Pargyline / Q000737:chemistry; D010627:Phenethylamines / Q000737:chemistry / Q000378:metabolism; D015202:Protein Engineering; D017386:Sequence Homology, Amino Acid; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000737:chemistry / Q000378:metabolism
D000588:Amines; D004800:Enzymes, Immobilized; D010627:Phenethylamines; D044005:Tetrahydroisoquinolines; C050386:1-methyl-1,2,3,4-tetrahydroisoquinoline; D010293:Pargyline; D008995:Monoamine Oxidase; C033198:1-phenethylamine