Norleucine, a natural occurrence in a novel ergot alkaloid gamma-ergokryptinine.
A novel natural peptide ergot alkaloid gamma-ergokryptinine containing norleucine has been isolated from ergot sclerotia of the field-growing parasitic fungus Claviceps purpurea CCM 8059. Its structure was deduced from the NMR and mass spectral data. The final structural proof was provided by the crystal structure determination, which is the first X-ray structure of a natural Nle-containing secondary metabolite. The conformations of three ergopeptinines: gamma-ergokryptinine, ergoladinine, and alpha-ergokryptinine were compared.
Cvak
L
L
IVAX Pharmaceuticals, R&D, Opava-Komárov, Czech Republic.
Jegorov
A
A
Sedmera
P
P
Císarová
I
I
Cejka
J
J
Kratochvíl
B
B
Pakhomova
S
S
D002967:Claviceps / Q000737:chemistry; D003460:Crystallization; D004876:Ergot Alkaloids / Q000737:chemistry*; D004879:Ergotamines / Q000737:chemistry*; D009646:Norleucine / Q000302:isolation & purification*; D019906:Nuclear Magnetic Resonance, Biomolecular
D004876:Ergot Alkaloids; D004879:Ergotamines; C511719:gamma-ergokryptinine; D009646:Norleucine