Quercetin alleviates activities of intestinal and renal disaccharidases in streptozotocin-induced diabetic rats.
Specific activities of both intestinal and renal dissacharidases, such as sucrase, maltase, and lactase, were altered in diabetic rats. Our study was focused to evaluate the effect of feeding quercetin - a bioflavanoid on intestinal and renal dissacharidases in streptozotocin-induced diabetic rats. The rats were fed with 0.1% quercetin in diet. A reduction in intestinal maltase and sucrase, activities in quercetin-fed diabetic rats was observed in contrast to the increased activities in the starch-fed diabetic rats. A significant amelioration in renal dissacharidase activities in quercetin-fed diabetic rats was observed when compared to decreased activity in starch-fed diabetic rats.
Ramachandra
Rashmi
R
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India.
Shetty
Ajaya K
AK
Salimath
Paramahans V
PV
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004186:Disaccharidases / Q000378:metabolism*; D006029:Glycosuria / Q000652:urine; D007422:Intestines / Q000201:enzymology*; D007668:Kidney / Q000201:enzymology*; D043322:Lactase / Q000378:metabolism; D008297:Male; D011794:Quercetin / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013213:Starch / Q000008:administration & dosage; D013393:Sucrase / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D013213:Starch; D011794:Quercetin; D004186:Disaccharidases; D043322:Lactase; D000520:alpha-Glucosidases; D013393:Sucrase