title: [Clinical anatomical features of chronic dysfunction in the transplanted kidney].
abstract: Histopathological features of transplanted kidneys which gradually lose graft function have been traditionally reported with the term of chronic rejection (CR). In 1997 Banff's classification indicated the adoption of a new term for all these histological features, namely Chronic allograft nephropathy (CAN), recommending that the presence of morphological aspects suggestive of chronic rejection, such as chronic transplant glomerulopathy (CTG) and proliferative endoarteritis (PE), has to be specified. On the basis of these criteria we reviewed the renal biopsies of 92 patients who underwent kidney transplantation from 1999 to 2002. In all cases the biopsy had been performed 6 months after organ transplantation. In 30 of the 92 patients CTG and/or PE was evident supporting a diagnosis of CR; on the contrary, in 11 of the 92 patients the final diagnosis based on histological evidence was that of CAN. Clinical and laboratory tests revealed that the presence of proteinuria in patients with CR at the time of diagnosis was the single statistically significant difference between these two groups. In 7 of the 32 patients where the diagnosis of CR was based on the presence of early features of CTG, the treatment with ACE-I induced complete remission of the proteinuria. Cyclosporine-induced arteriolopathy (CSA) represents an additional histological finding which has been associated with graft loss in the transplanted kidney. The observation of arteriolopathy, similar to CSA in patients who did not receive calcineurine inhibitors, suggests some caution in the use of this diagnostic criteria.
authors.affiliation: II Servizio di Anatomia Patologica, Divisione di Nefrologia, Spedali Civili Universita' di Brescia, Brescia. tardanico.regina@tiscali.it
authors.forename: R
authors.initials: R
authors.lastname: Tardanico
authors.forename: S
authors.initials: S
authors.lastname: Sandrini
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D019703:Calcineurin / Q000378:metabolism; D002908:Chronic Disease; D005260:Female; D006084:Graft Rejection / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000209:etiology; D012189:Retrospective Studies
chemical_list: D019703:Calcineurin