An efficient synthesis of propargylamines via C-H activation catalyzed by copper(I) in ionic liquids.
A readily available copper(I) catalyst, in an ionic liquid, can effect three-component coupling of aldehydes, amines and alkynes to generate propargylamines in high yields.
Park
Soon Bong
SB
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie Ottawa, ON, Canada K1N 6N5.
Alper
Howard
H
D000447:Aldehydes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D015394:Molecular Structure; D010293:Pargyline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011437:Propylamines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; D000480:Alkynes; D000588:Amines; D052578:Ionic Liquids; D011437:Propylamines; C009054:propargylamine; D003300:Copper; D010293:Pargyline