Effects of dietary n-3 polyunsaturated fatty acids on T-cell membrane composition and function.
Dietary n-3 PUFA have been shown to attenuate T-cell-mediated inflammation, in part, by suppressing T-cell activation and proliferation. n-3 PUFA have also been shown to promote apoptosis, another important mechanism for the prevention of chronic inflammation by maintaining T-cell homeostasis through the contraction of populations of activated T cells. Recent studies have specifically examined Fas death receptor-mediated activation-induced cell death (AICD), since it is the form of apoptosis associated with peripheral T-cell deletion involved in immunological tolerance and T-cell homeostasis. Data from our laboratory indicate that n-3 PUFA promote AICD in T helper 1 polarized cells, which are the mediators of chronic inflammation. Since Fas and components of the death-inducing signaling complex are recruited to plasma membrane microdomains (rafts), the effect of dietary n-3 PUFA on raft composition and resident protein localization has been the focus of recent investigations. Indeed, there is now compelling evidence that dietary n-3 PUFA are capable of modifying the composition of T-cell membrane microdomains (rafts). Because the lipids found in membrane microdomains actively participate in signal transduction pathways, these results support the hypothesis that dietary n-3 PUFA influence signaling complexes and modulate T-cell cytokinetics in vivo by altering T-cell raft composition.
Switzer
Kirsten C
KC
Molecular and Cell Biology Section, Faculty of Nutrition, Texas A&M University Health Science Center, College Station, Texas 77843-2471, USA.
McMurray
David N
DN
Chapkin
Robert S
RS
D000818:Animals; D017209:Apoptosis; D002462:Cell Membrane / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology; D049109:Cell Proliferation; D004041:Dietary Fats / Q000494:pharmacology; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology* / Q000502:physiology; D005231:Fatty Acids, Unsaturated / Q000502:physiology; D006801:Humans; D013601:T-Lymphocytes / Q000737:chemistry* / Q000166:cytology / Q000502:physiology
D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated
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