title: Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone.
abstract: Human aging is characterized by debilitating diseases, including heart failure, cardiac pacemaker defects, muscle wasting, and osteoporosis, in heart, skeletal muscle, and bone. Recent studies are identifying pathways for these aging-related diseases by examining how the process of aging influences tissue-specific progenitors and differentiated cell lineages in these organ systems. These advances form a foundation for new therapeutic strategies to delay the onset of aging-related disorders.
authors.affiliation: UCSD Institute of Molecular Medicine, UCSD School of Medicine, La Jolla, California 92093, USA. kchien@partners.org
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Chien
authors.forename: Gerard
authors.initials: G
authors.lastname: Karsenty
mesh_terms: D001851:Bone Diseases, Metabolic / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D016723:Bone Remodeling / Q000235:genetics / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D019070:Cell Lineage / Q000235:genetics / Q000502:physiology*; D004272:DNA, Mitochondrial / Q000235:genetics / Q000502:physiology; D006331:Heart Diseases / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D008136:Longevity / Q000235:genetics / Q000502:physiology*; D009135:Muscular Diseases / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D009154:Mutation / Q000235:genetics / Q000502:physiology
chemical_list: D004272:DNA, Mitochondrial; D007334:Insulin-Like Growth Factor I