title: Molecular biology of ureteral bud and trigonal development.
abstract: Advances in molecular biology have provided valuable insight into the development of the urinary tract, particularly ureteral bud formation. Reciprocal inductive signals between the ureteral bud and growing kidney are crucial for normal development. The Wolffian duct serves as the site of origin of the ureteral bud and forms distal excretory ducts that are incorporated into the developing bladder to become the trigone. Vesicoureteral reflux and renal dysplasia can result from abnormal position of the ureteral orifice on the trigone. The presumed origin of trigone formation is based largely on evaluation of human and animal models performed nearly a century ago. The trigone is thought to develop from the mesodermal germ cell layer; however, several recent studies have shown that endoderm may be the tissue of origin. This review highlights important discoveries in the field of molecular biology as it relates to the development of normal and abnormal ureteral bud formation. It also describes the anatomic relationship between the developing bud and trigone as it pertains to clinically relevant urinary tract anomalies, including recent discoveries that attempt to prove the origin of the trigone.
authors.affiliation: Department of Urologic Surgery, Division of Pediatric Urology, Vanderbilt Children's Hospital, 435 Medical Arts Building, 1211 21st Avenue South, Nashville, TN 37212-2721, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Thomas
authors.forename: Romano T
authors.initials: RT
authors.lastname: DeMarco
authors.forename: John C
authors.initials: JC
authors.lastname: Pope
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000196:embryology*; D008297:Male; D008967:Molecular Biology; D038081:Organogenesis / Q000502:physiology*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D014513:Ureter / Q000196:embryology*; D014566:Urogenital System / Q000196:embryology; D014718:Vesico-Ureteral Reflux / Q000209:etiology / Q000503:physiopathology
references.citation: Kidney Int. 2002 Jan;61(1):10-9
references.pmid: 11786080
references.citation: Development. 1997 Oct;124(20):4077-87
references.pmid: 9374404
references.citation: Dev Biol. 2004 Feb 15;266(2):285-98
references.pmid: 14738877
references.citation: Mol Cell. 1999 Jan;3(1):1-10
references.pmid: 10024874
references.citation: Development. 2001 Dec;128(23):4747-56
references.pmid: 11731455
references.citation: J Urol. 2002 Sep;168(3):1165-72
references.pmid: 12187262
references.citation: Curr Opin Genet Dev. 2000 Oct;10(5):543-9
references.pmid: 10980433
references.citation: J Urol. 2002 Jun;167(6):2339-50; discussion 2350-1
references.pmid: 11992035
references.citation: Semin Cell Dev Biol. 2003 Aug;14(4):217-24
references.pmid: 14627120
references.citation: Development. 1997 May;124(9):1653-64
references.pmid: 9165114
references.citation: J Am Soc Nephrol. 1999 Sep;10(9):2018-28
references.pmid: 10477156
references.citation: Development. 1995 Dec;121(12):4057-65
references.pmid: 8575306
references.citation: J Urol. 1998 Sep;160(3 Pt 2):1070-4
references.pmid: 9719278
references.citation: J Urol. 2001 Jan;165(1):196-202
references.pmid: 11125405
references.citation: Cancer Surv. 1991;11:73-90
references.pmid: 1841758
references.citation: Development. 2003 Jul;130(14):3175-85
references.pmid: 12783789
references.citation: Mech Dev. 1997 Mar;62(2):105-20
references.pmid: 9152004
references.citation: Urology. 1978 Feb;11(2):161-3
references.pmid: 628993
references.citation: Science. 1953 Jul 10;118(3054):52-5
references.pmid: 13076182
references.citation: J Clin Invest. 2000 Apr;105(7):863-73
references.pmid: 10749566
references.citation: J Urol. 1965 Feb;93:165-76
references.pmid: 14260208
references.citation: J Urol. 1975 Aug;114(2):274-80
references.pmid: 1171997
references.citation: Development. 1996 Jun;122(6):1919-29
references.pmid: 8674430
references.citation: J Urol. 1996 Nov;156(5):1820-7
references.pmid: 8863624
references.citation: J Urol. 1968 Nov;100(5):623-32
references.pmid: 5682537
references.citation: J Urol. 2001 Nov;166(5):1848-52
references.pmid: 11586245
references.citation: Kidney Int. 1995 Jan;47(1):140-7
references.pmid: 7731139