Hepatoprotective constituents of Cudrania tricuspidata.
Phytochemical investigation of the MeOH extract of the root barks of Cudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activity in vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4). All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds 1, 2, and 4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.
Tian
Yu-Hua
YH
College of Pharmacy and Phytofermentation Research Center, Wonkwang University, Iksan 570-749, Korea.
Kim
Hyun-Chul
HC
Cui
Jiong-Mo
JM
Kim
Youn-Chul
YC
D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000517:prevention & control; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D029586:Moraceae; D009582:Nitrofurantoin / Q000633:toxicity; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots
D010936:Plant Extracts; D009582:Nitrofurantoin