[Effects of processing Phellodendron amurense with salt on anti-gout].
OBJECTIVE
To investigate the effects of processing Phellodendron anurene with salt on anti-gout.


METHODS
The mouse serum uric acid level and liver xanthine oxidase activity were used to evaluate anti-gout effects of raw and processing P. amurense with salt.


RESULTS
Both raw and processing P. amurense with salt reduced serum uric acid levels in the in hyperuricemic mice, and inhibited activities of liver xanthine oxidase at the low and high doses respectively, thus exhibiting anti-gout effects. Moreover, they showed the tendency to decrease the uric acid levels in the normal animal only at the high dose. The latter was a little weaker than the former.


CONCLUSIONS
Processing with salt might not significantly change anti-gout effect of P. amurense.
Yang
Cheng
C
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China.
Zhu
Ji-xiao
JX
Wang
Yin
Y
Wen
Yao-lin
YL
Kong
Ling-dong
LD
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D006074:Gout Suppressants / Q000494:pharmacology*; D006358:Hot Temperature; D033461:Hyperuricemia / Q000097:blood / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D032102:Phellodendron / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012965:Sodium Chloride; D013678:Technology, Pharmaceutical / Q000379:methods; D014527:Uric Acid / Q000097:blood; D014969:Xanthine Oxidase / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D006074:Gout Suppressants; D014527:Uric Acid; D012965:Sodium Chloride; D014969:Xanthine Oxidase