title: Hepatoprotective constituents of Cudrania tricuspidata.
abstract: Phytochemical investigation of the MeOH extract of the root barks of Cudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activity in vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4). All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds 1, 2, and 4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.
authors.affiliation: College of Pharmacy and Phytofermentation Research Center, Wonkwang University, Iksan 570-749, Korea.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Tian
authors.forename: Hyun-Chul
authors.initials: HC
authors.lastname: Kim
authors.forename: Jiong-Mo
authors.initials: JM
authors.lastname: Cui
authors.forename: Youn-Chul
authors.initials: YC
authors.lastname: Kim
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000517:prevention & control; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D029586:Moraceae; D009582:Nitrofurantoin / Q000633:toxicity; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots
chemical_list: D010936:Plant Extracts; D009582:Nitrofurantoin