Organization of vesicular trafficking in epithelia.
Experiments using mammalian epithelial cell lines have elucidated biosynthetic and recycling pathways for apical and basolateral plasma-membrane proteins, and have identified components that guide apical and basolateral proteins along these pathways. These components include apical and basolateral sorting signals, adaptors for basolateral signals, and docking and fusion proteins for vesicular trafficking. Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking.
Rodriguez-Boulan
Enrique
E
Margaret Dyson Vision Research Institute, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA. boulan@med.cornell.edu
Kreitzer
Geri
G
Müsch
Anne
A
D033942:Adaptor Proteins, Vesicular Transport / Q000502:physiology; D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D022162:Cytoplasmic Vesicles / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D004285:Dogs; D004848:Epithelium / Q000502:physiology*; D007668:Kidney / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D033942:Adaptor Proteins, Vesicular Transport