title: Effect of Hewei-Decoction on chronic atrophic gastritis and eradication of Helicobacter pylori.
abstract: OBJECTIVE
  To demonstrate the effect of Hewei-Decoction (Decoction for regulating the stomach) on chronic atrophic gastritis (CAG) and eradication of Helicobacter pylori.
  
  
  METHODS
  Ninety patients with CAG entering the investigation were divided into six differentiation syndromes, based on their major symptoms and signs. Hewei-Decoction was taken by all the patients orally for 4 or 8 wk. The efficacy was assessed by both the composite accumulation of reduced scores of major symptoms and the eradication of H pylori. chi(2) test was used to compare the efficacy between H pylori-positive and negative cases, and to disclose the relationship between efficacy and eradication of H pylori.
  
  
  RESULTS
  In patients with six different syndrome types, the efficacy of Hewei-Decoction was 91.67% (11/12), 92.86% (13/14), 97.22% (35/36), 87.50% (14/16), 75.00% (6/8), 75.00% (3/4) respectively. The rate of highly efficacious was 58.33% (7/12), 50.00% (7/14), 77.78% (28/36), 62.50% (10/16), 12.50% (1/8) and 25.00% (1/4), respectively. The total efficacy was 91.11% (82/90), and the rate of highly efficacious was 60.00% (54/90). The eradication rate of H pylori was 67.86% (38/56). The therapeutic effect of Hewei-Decoction was better in H pylori positive cases than that in H pylori-negative cases with the total effect of 96.43% vs 82.35% (P<0.05). In 56 H pylori positive cases, the therapeutic effect was better in H pylori eradicated cases than that in H pylori- existent cases with the total effect of 97.37% vs 72.22% (P<0.01).
  
  
  CONCLUSIONS
  Hewei-Decoction is effective in most cases of all the syndrome types. The results indicate that eradication of H pylori is one of the important mechanisms for alleviation of symptoms and signs. Also, the decoction is efficacious in H pylori-negative cases.
authors.affiliation: Department of Internal Medicine, Weifang Medical College, Weifang 261042, Shandong Province, China. jiwsh@wfmc.edu.cn
authors.forename: Wan-Sheng
authors.initials: WS
authors.lastname: Ji
authors.forename: Zhi-Xing
authors.initials: ZX
authors.lastname: Gao
authors.forename: Kai-Chun
authors.initials: KC
authors.lastname: Wu
authors.forename: Jun-Wen
authors.initials: JW
authors.lastname: Qiu
authors.forename: Bing-Long
authors.initials: BL
authors.lastname: Shi
authors.forename: Dai-Ming
authors.initials: DM
authors.lastname: Fan
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001284:Atrophy; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004365:Drugs, Chinese Herbal
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