[Recognition of virus infected cells by NK cells].
NK cells show cytotoxicity against virus-infected cells and tumor cells and play an important role in host defense. Although mecheanism of target cell recognition by NK cells have been unclear for a long time, it has recently been elucidated that certain NK cell receptors specifically recognize virus products. Furthermore, expression pattern of NK cell receptors, which consist of activating and inhibitory receptors, determines susceptibility to virus-infection. Here, we review recent progress of mechanism of recognition of virus-infected by NK cells.
Arase
Hisashi
H
Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University 3-1 Yamadaoka, Suita, 565-0871, Japan. arase@biken.osaka-u.ac.jp
Shiratori
Ikuo
I
D000818:Animals; D015703:Antigens, CD; D000954:Antigens, Surface / Q000276:immunology; D019143:Evolution, Molecular; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology; D064446:Orexin Receptors; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic / Q000276:immunology / Q000502:physiology; D015398:Signal Transduction; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000276:immunology*
D015703:Antigens, CD; D000954:Antigens, Surface; C492346:CD200 receptor, mouse; C477337:CD200R1 protein, human; C501103:Cd200r1 protein, mouse; D015395:Histocompatibility Antigens Class I; D008562:Membrane Glycoproteins; D064446:Orexin Receptors; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C042739:antigens, CD200