title: [Clear cell dermatofibroma: a case report with cytogenetic study].
abstract: We report an observation concerning a 48-year-old male who presented with a 5 cm tumour on his left leg, first noticed 18 months ago. The remainder of clinical examination was normal. Histological assessment revealed a tumoral infiltration of entire dermis and superficial hypodermis. This tumour consisted of monomorphous, ovoid or spindle cells, with clear cytoplasm and PAS+ granulations. There was strong immunoreactivity by tumoral cells only for vimentin. Ultrastructural studies revealed fibrohistiocytic-like tumoral cells, without epithelial, muscular, vascular or melanocytic differentiation. These results were consistent with the diagnosis of clear cell dermatofibroma. Cytogenetic evaluation and FISH analysis showed a deletion of p12. Clear cell dermatofibroma is a rare and recent variant of dermatofibroma, with a difficult histological evaluation and which must be differentiated from clear-cell sarcoma. This observation is the first case-report of this entity, to our knowledge, showing a cytogenetic abnormality.
authors.affiliation: Service d'Anatomie Pathologique, Hôpital Charles Nicolle, CHU de Rouen. celine.riopel@wanadoo.fr
authors.forename: Céline
authors.initials: C
authors.lastname: Riopel
authors.forename: Philippe
authors.initials: P
authors.lastname: Musette
authors.forename: Corinne
authors.initials: C
authors.lastname: Bodenant
authors.forename: Philippe
authors.initials: P
authors.lastname: Belanyi
authors.forename: Pascal
authors.initials: P
authors.lastname: Joly
authors.forename: Philippe
authors.initials: P
authors.lastname: Courville
mesh_terms: D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D020732:Cytogenetic Analysis; D003937:Diagnosis, Differential; D017353:Gene Deletion; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin