title: Statistical correlation between transient pressure drop and cavitation at closure of a mechanical heart valve.
abstract: Cavitation on a mechanical heart valve (MHV) is attributable to transient regional pressure drop at the instant of valve closure. As a cavitation bubble collapses, it emits shock waves, which have the characteristics of high frequency oscillations (HFO) on a pressure time trace. The potential for such HFO bursts to cause material damage on an MHV can be measured by the cavitation impulse I, which is defined as the area under the trace of the HFO bursts. In the present study, experiments were conducted on a bileaflet MHV in a durability tester, operated at pulse rates from 300-1,000 bpm. In each case, the transient pressure near an occluder was monitored for 60,000 beats via a transducer. The peak pressure drop Pm and the corresponding cavitation impulse I obtained for the 60,000 beat sequence are found to resemble sample records of two stationary stochastic processes, each of which follows a log normal distribution. Their first order probability density functions are estimated from the records. The correlation is investigated between I and Pm associated with each beat, which is found to be of statistical significance.
authors.affiliation: Center for Applied Stochastics Research, College of Engineering, Florida Atlantic University, 777 Glades Rd., Boca Raton, FL 33431, USA.
authors.forename: Changfu
authors.initials: C
authors.lastname: Wu
authors.forename: Jia-Shing
authors.initials: JS
authors.lastname: Liu
authors.forename: Ned H C
authors.initials: NH
authors.lastname: Hwang
authors.forename: Yu-Kweng M
authors.initials: YK
authors.lastname: Lin
mesh_terms: D001698:Biomedical Engineering; D006339:Heart Rate; D006350:Heart Valve Prosthesis / Q000706:statistics & numerical data*; D008422:Materials Testing / Q000706:statistics & numerical data*; D011312:Pressure; D011338:Probability Theory; D011474:Prosthesis Design; D013995:Time; D014159:Transducers