Maternal exposure to androstenedione does not induce developmental toxicity in the rat.
Thirty-day old female rats received corn oil or androstenedione (in corn oil) at one of four concentrations (5.0, 10.0, 30.0 or 60.0 mg/kg body weight) by gavage for two weeks prior to mating, during the mating period and until gestation day (GD) 19. Caesarean sections were performed on GD 20. No dose related changes were observed in serum androstenedione, estradiol, LH, FSH, testosterone or progesterone. A statistically significant decrease in estrous cycle length was observed in the 60.0 mg/kg dose group only. Feed and fluid consumption, mean body weight gain, organ weight and fetal parameters were not affected by androstenedione treatment. At the doses given, androstenedione had no specific effect on the development of individual bones or soft tissues.
Sprando
Robert L
RL
Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD 20708, USA. rsprando@cfsan.fda.gov
Collins
Thomas F X
TF
Black
Thomas N
TN
Olejnik
Nicholas
N
Sapienza
Philip
P
Ramos-Valle
Moraima
M
Ruggles
Dennis I
DI
D000284:Administration, Oral; D000735:Androstenedione / Q000633:toxicity*; D000818:Animals; D001842:Bone and Bones / Q000196:embryology; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects* / Q000502:physiology; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats
D000735:Androstenedione