title: Ziprasidone-induced galactorrhea: a case report.
abstract: OBJECTIVE
  Second-generation antipsychotics presumably lack the typical side effects of conventional antipsychotics.
  
  
  METHODS
  A 34 year old Caucasian woman with ICD-10 diagnosis of Recurrent depressive disorder with current moderate symptoms, and with a history of repeated self-injury was treated with lithium, clonazepam and ziprasidone.
  
  
  RESULTS
  On the ninth day of ziprasidone administration, galactorrhea appeared. After 36 days of ziprasidone therapy, galactorrhea persisted. The prolactin plasma level was 28 ng/ml. Thyroid tests (TSH,T3,T4) and the lithium plasma level were within the normal range during ziprasidone treatment. Two weeks after the ziprasidone withdrawal, galactorrhea disappeared and the prolactin level decreased down to 18 ng/ml.
  
  
  CONCLUSIONS
  Psychiatrists should be aware that even second-generation antipsychotics, including ziprasidone, have a propensity to cause side-effects associated with the dopamine D2 receptor blockade, such as galactorrhea.
authors.affiliation: Psychiatric Centre Prague, Czech Republic. kopecek@pcp.lf3.cuni.cz
authors.forename: Miloslav
authors.initials: M
authors.lastname: Kopecek
authors.forename: Martin
authors.initials: M
authors.lastname: Bares
authors.forename: Pavel
authors.initials: P
authors.lastname: Mohr
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000652:urine; D002998:Clonazepam / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000652:urine; D005260:Female; D005687:Galactorrhea / Q000139:chemically induced* / Q000652:urine; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D010879:Piperazines / Q000009:adverse effects* / Q000627:therapeutic use; D011388:Prolactin / Q000097:blood; D012008:Recurrence; D013844:Thiazoles / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; D002998:Clonazepam; C092292:ziprasidone; D011388:Prolactin; D008094:Lithium