In vitro release of cisplatin from sol-gel processed porous silica xerogels.
Cisplatin an antineoplastic medicine, was incorporated into a silica gel received by the sol-gel method. Various techniques of trapping an active substance in gel were applied: at the stage of sol creation--by the predoping method--and already upon receipt of hard xerogel--the postdoping method. Further, the research aimed at the determination of the dynamics of cisplatin release from sol-gel processed silica xerogel to the water phase. Based on the achieved results, we may state that the sol-gel method is useful for trapping a medicine like cisplatin in silica gel and gives repeatable results with regard to medicine release from the pores of the so-established matrix. The postdoping method appeared to be more beneficial, because the gained gel's active substance is released almost entirely (94-96%). The time of release was 3 days.
Czarnobaj
K
K
Department of Physical Chemistry with Laboratory of Instrumental Analysis, Medical University of Gdańsk, al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland. kczar@biology.pl
Lukasiak
J
J
D002945:Cisplatin / Q000493:pharmacokinetics*; D044367:Phase Transition; D016062:Porosity; D058428:Silica Gel; D012822:Silicon Dioxide / Q000493:pharmacokinetics*
D058428:Silica Gel; D012822:Silicon Dioxide; D002945:Cisplatin