A pyrimidine-like nickel(II) DNA base pair.
4-(2'-Pyridyl)-pyrimidinone deoxyriboside is synthesized and characterized as a DNA metallo base-pair; this novel nucleoside forms a self-pair in the presence of Ni(II) and stabilizes double helical DNA to the same extent as a G.C pair.
Switzer
Christopher
C
Department of Chemistry, University of California, Riverside, CA, USA. switzer@citrus.ucr.edu
Shin
Dongwon
D
D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D013696:Temperature
D009942:Organometallic Compounds; D011743:Pyrimidines; D009532:Nickel; D004247:DNA