title: Antidiuretic hormone-V2-receptor-aquaporin-2 system in rat kidneys during acute inflammation.
abstract: Expression of antidiuretic hormone V(2)-receptor, water channel protein aquaporin-2, and cytokines interleukin-1b and interleukin-6 was studied in the kidneys of rats with acute inflammation produced by intraperitoneal injection of lipopolysaccharide in a dose of 250 microg/100 g. Reduced expression of aquaporin-2 and V(2)-receptor led to impairment of concentration capacity in the kidneys and decrease in urine osmolarity.
authors.affiliation: Research Center of Endocrinology, Russian Academy of Medical Sciences, Moscow, Russia. aml@mail.ru
authors.forename: A V
authors.initials: AV
authors.lastname: Misharin
authors.forename: A B
authors.initials: AB
authors.lastname: Resnenko
authors.forename: O V
authors.initials: OV
authors.lastname: Fidelina
authors.forename: V V
authors.initials: VV
authors.lastname: Grinevich
authors.forename: I G
authors.initials: IG
authors.lastname: Akmaev
mesh_terms: D000208:Acute Disease; D000818:Animals; D051399:Aquaporin 2; D020346:Aquaporins / Q000502:physiology*; D004195:Disease Models, Animal; D004926:Escherichia coli; D007249:Inflammation / Q000503:physiopathology*; D007375:Interleukin-1 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D007668:Kidney / Q000503:physiopathology*; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017483:Receptors, Vasopressin / Q000502:physiology*; D012016:Reference Values; D012964:Sodium / Q000097:blood
chemical_list: C496025:Aqp2 protein, rat; D051399:Aquaporin 2; D020346:Aquaporins; D007375:Interleukin-1; D015850:Interleukin-6; D008070:Lipopolysaccharides; D017483:Receptors, Vasopressin; D012964:Sodium