The role of insulin and IGF-1 signaling in longevity.
There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.
Katic
M
M
Joslin Diabetes Center and Department of Medicine Harvard Medical School, Boston, Massachusetts 02215, USA.
Kahn
C R
CR
D000375:Aging; D000818:Animals; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008136:Longevity / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D007328:Insulin; D007334:Insulin-Like Growth Factor I