title: Efficient conversion of Biginelli 3,4-dihydropyrimidin-2(1H)-one to pyrimidines via PyBroP-mediated coupling.
abstract: An efficient two-step procedure is described to convert the Biginelli 3,4-dihydropyrimidin-2(1H)-one to various multifunctionalized pyrimidines via the Kappe dehydrogenation and a new mild PyBroP-mediated coupling with C, N, O, and S nucleophiles, which provides a readily accessible multifunctionalized pyrimidine template for diversity-oriented synthesis.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development, LLC, 1000 Route 202, Raritan, New Jersey 08869, USA. fkang@prdus.jnj.com
authors.forename: Fu-An
authors.initials: FA
authors.lastname: Kang
authors.forename: Jason
authors.initials: J
authors.lastname: Kodah
authors.forename: Qunying
authors.initials: Q
authors.lastname: Guan
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Li
authors.forename: William V
authors.initials: WV
authors.lastname: Murray
mesh_terms: D006865:Hydrogenation; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis*; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D011743:Pyrimidines; D011744:Pyrimidinones