title: Antiallergic, antipyretic, hypoglycemic and hepatoprotective effects of aqueous extract of Coronopus didymus Linn.
abstract: The aqueous extract of whole plant of Coronopus didymus LINN (CD) [Family: Bracicacea] was screened for antiallergic, antipyretic and hepatoprotective effects in rats and hypoglycemic activity in mice. The extract showed significant antiallergic, antipyretic, hypoglycemic and hepatoprotective activity at 200 and 400 mg/kg doses on oral administration. Mechanistically, CD acts as an antioxidant as evidenced by its ability to scavenge DPPH and superoxide radicals. All the observed activities may be due to the presence of flavonoids, saponins and tannins as they are reported to possess a variety of biological activities.
authors.affiliation: Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India. sudheerkumarm99@yahoo.com
authors.forename: Sudheer Kumar
authors.initials: SK
authors.lastname: Mantena
authors.forename: Srinivasa
authors.initials: S
authors.lastname: Mutalik
authors.forename: Hullegala
authors.initials: H
authors.lastname: Srinivasa
authors.forename: Ganesa Sundararajan
authors.initials: GS
authors.lastname: Subramanian
authors.forename: Koiram Rajanna
authors.initials: KR
authors.lastname: Prabhakar
authors.forename: Kasu Raghurami
authors.initials: KR
authors.lastname: Reddy
authors.forename: Keloth Kaitheri
authors.initials: KK
authors.lastname: Srinivasan
authors.forename: Mazhuvancherry Kesavan
authors.initials: MK
authors.lastname: Unnikrishnan
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D019607:Brassicaceae; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D014867:Water
chemical_list: D018712:Analgesics, Non-Narcotic; D018926:Anti-Allergic Agents; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014867:Water