title: Glaucopines A and B, new cyathane diterpenes from the fruiting bodies of Sarcodon glaucopus.
abstract: Glaucopine A (1) and B (2), two new cyathane diterpenes, have been isolated from the mushroom Sarcodon glaucopus: their structures have been determined on the basis of spectral data. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice: compounds 1 and 2 (1 micromol/cm2) provoked edema reduction (62 % and 55 %, respectively) similar to that induced by the reference non-steroidal anti-inflammatory drug, indomethacin (0.3 micromol/cm2, 61 % edema reduction).
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Sez. Chimica Organica, Università degli Studi, Perugia, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Curini
authors.forename: Federica
authors.initials: F
authors.lastname: Maltese
authors.forename: Maria Carla
authors.initials: MC
authors.lastname: Marcotullio
authors.forename: Luigi
authors.initials: L
authors.lastname: Menghini
authors.forename: Rita
authors.initials: R
authors.lastname: Pagiotti
authors.forename: Ornelio
authors.initials: O
authors.lastname: Rosati
authors.forename: Gianmario
authors.initials: G
authors.lastname: Altinier
authors.forename: Aurelia
authors.initials: A
authors.lastname: Tubaro
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001487:Basidiomycota; D003436:Croton Oil; D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005638:Fruit; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D010936:Plant Extracts; C497675:cyathane; D003436:Croton Oil