title: Effects of oral cortisol treatment in healthy young women on memory retrieval of negative and neutral words.
abstract: Studies in rodents have demonstrated that glucocorticoids enhance memory consolidation but impair delayed memory retrieval. Similar findings have been reported in humans. Emotional items are better remembered than neutral items. However, it is unknown if emotional valence influences the effects of cortisol on retrieval. In this double-blind crossover study, 16 healthy women learned a wordlist containing 15 neutral and 15 negative words. Delayed recall was tested 5h later. Cortisol administered before recall testing significantly reduced retrieval (p<.01). Exploratory follow-up analysis revealed that cortisol significantly impaired retrieval of negative words (p<.01), while having no significant effect on neutral words (p=.47). The current findings could suggest that emotional material is especially sensitive to the memory modulating effects of stress hormones.
authors.affiliation: Institute of Experimental Psychology, University of Duesseldorf, Germany.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Kuhlmann
authors.forename: Clemens
authors.initials: C
authors.lastname: Kirschbaum
authors.forename: Oliver T
authors.initials: OT
authors.lastname: Wolf
mesh_terms: D000328:Adult; D001288:Attention / Q000187:drug effects / Q000502:physiology; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004644:Emotions; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000494:pharmacology*; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology; D011939:Mental Recall / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012153:Retention, Psychology / Q000187:drug effects* / Q000502:physiology; D012660:Semantics; D014706:Verbal Learning / Q000187:drug effects* / Q000502:physiology
chemical_list: D006854:Hydrocortisone