Structural and functional characterization of polyphenols isolated from acerola (Malpighia emarginata DC.) fruit.
Two anthocyanins, cyanidin-3-alpha-O-rhamnoside (C3R) and pelargonidin-3-alpha-O-rhamnoside (P3R), and quercitrin (quercetin-3-alpha-O-rhamnoside), were isolated from acerola (Malpighia emarginata DC.) fruit. These polyphenols were evaluated based on the functional properties associated with diabetes mellitus or its complications, that is, on the radical scavenging activity and the inhibitory effect on both alpha-glucosidase and advanced glycation end product (AGE) formation. C3R and quercitrin revealed strong radical scavenging activity. While the inhibitory profiles of isolated polyphenols except quercitrin towards alpha-glucosidase activity were low, all polyphenols strongly inhibited AGE formation.
Hanamura
Takayuki
T
Research and Development Division, Processed Foods Company, Nichirei Corporation, Chiba, Japan. hanamurat@nichirei.co.jp
Hagiwara
Toshihiko
T
Kawagishi
Hirokazu
H
D000872:Anthocyanins / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000302:isolation & purification; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors; D065089:Glycoside Hydrolase Inhibitors; D029581:Malpighiaceae / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology*; D059808:Polyphenols; D011794:Quercetin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D012210:Rhamnose / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
D000872:Anthocyanins; D000975:Antioxidants; D005419:Flavonoids; D017127:Glycation End Products, Advanced; D065089:Glycoside Hydrolase Inhibitors; D010636:Phenols; D059808:Polyphenols; C502042:cyanidin-3-O-rhamnoside; C502043:pelargonidin-3-O-rhamnoside; C012526:quercitrin; D011794:Quercetin; D012210:Rhamnose