Dissociation between extension of the sensitive period for avian vocal learning and dendritic spine loss in the song nucleus lMAN.
Several instances of early learning coincide with significant rearrangements of neural connections in regions contributing to these behaviors. In fact developmentally restricted learning may be constrained temporally by the opportunity for experience to selectively maintain appropriate synapses amidst the elimination of exuberant connections. Consistent with this notion, during the normal sensitive period for vocal learning in zebra finches (Taenopygia guttata), there is a decline in the density of dendritic spines within a region essential for song development, the lateral magnocellular nucleus of the anterior nidopallium (lMAN). Moreover, in birds isolated from conspecific song shortly after hatching, both the closure of the sensitive period for vocal learning and the pruning of spines from lMAN neurons is delayed. Here, we employed a more subtle form of deprivation to delay the close of the sensitive period for song learning, and found that late song learning occurred without obvious alterations in the pruning of dendritic spines on lMAN neurons. At posthatch day (PHD) 65 (beyond the end of the normal sensitive period for song memorization in zebra finches), birds isolated from song beginning on PHD30 did not differ from normally reared birds in measures of dendritic spine density on Golgi-Cox stained lMAN neurons. Moreover, tutor exposure from PHD65 to 90 did not increase spine elimination in these isolates (who memorized new song material) relative to controls (who did not). Thus, we conclude that the extent of normally occurring lMAN spine loss is not sufficient to account for the timing of the sensitive period for zebra finch song learning.
Heinrich
J E
JE
Department of Brain and Cognitive Sciences, 116 Meliora Hall, University of Rochester, River Campus, Rochester, NY 14627, USA.
Nordeen
K W
KW
Nordeen
E J
EJ
D000818:Animals; D001931:Brain Mapping; D003423:Critical Period, Psychological; D049229:Dendritic Spines / Q000502:physiology*; D020392:Entopeduncular Nucleus / Q000502:physiology*; D046369:Finches / Q000502:physiology*; D007100:Imitative Behavior / Q000502:physiology*; D007173:Imprinting, Psychological / Q000502:physiology*; D008297:Male; D011939:Mental Recall / Q000502:physiology; D009415:Nerve Net / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010898:Pitch Perception / Q000502:physiology*; D012683:Sensory Deprivation / Q000502:physiology; D012934:Social Isolation; D013569:Synapses / Q000502:physiology; D014828:Vocalization, Animal / Q000502:physiology*