title: Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70.
abstract: Inflammation may play an important role in the pathophysiology of sickle cell disease (SCD), and recent studies have identified the 70-kDa heat shock protein (Hsp70) as an important mediator of inflammatory responses. Here we demonstrate a significant increase in circulating serum Hsp70 level in SCD during vaso-occlusive crisis (VOC) as compared with baseline steady-state levels (P <0.05) and a significant increase in Hsp70 levels in SCD at baseline compared with normal controls (P <0.05). Taken together, these results indicate that circulating serum Hsp70 might be a marker for VOC in SCD.
authors.affiliation: Center for Excellence in Sickle Cell Disease, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
authors.forename: Adeboye H
authors.initials: AH
authors.lastname: Adewoye
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Klings
authors.forename: Harrison W
authors.initials: HW
authors.lastname: Farber
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Palaima
authors.forename: Maria A
authors.initials: MA
authors.lastname: Bausero
authors.forename: Lillian
authors.initials: L
authors.lastname: McMahon
authors.forename: Adam
authors.initials: A
authors.lastname: Odhiambo
authors.forename: Safaya
authors.initials: S
authors.lastname: Surinder
authors.forename: Mark
authors.initials: M
authors.lastname: Yoder
authors.forename: Martin H
authors.initials: MH
authors.lastname: Steinberg
authors.forename: Alexzander
authors.initials: A
authors.lastname: Asea
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications; D015415:Biomarkers / Q000097:blood; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D014652:Vascular Diseases / Q000097:blood* / Q000209:etiology
chemical_list: D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins
references.citation: N Engl J Med. 1991 Jul 4;325(1):11-6
references.pmid: 1710777
references.citation: Nat Med. 2000 Apr;6(4):435-42
references.pmid: 10742151
references.citation: Blood. 2000 Jul 1;96(1):314-20
references.pmid: 10891467
references.citation: J Biol Chem. 2002 Apr 26;277(17):15028-34
references.pmid: 11836257
references.citation: Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L705-14
references.pmid: 12972407
references.citation: Respir Res. 2001;2(5):280-5
references.pmid: 11686897
references.citation: Am J Physiol. 1999 Oct;277(4 Pt 2):H1579-92
references.pmid: 10516198