(-)-Echinobetaine A: isolation, structure elucidation, synthesis, and SAR studies on a new nematocide from a southern Australian marine sponge, Echinodictyum sp.
A nematocidal agent present in a southern Australian marine sponge of the genus Echinodictyum has been isolated and identified by detailed spectroscopic analysis and total synthesis as the novel betaine (-)-echinobetaine A (6). Preliminary SAR investigations have been undertaken.
Capon
Robert J
RJ
Centre for Molecular Biodiversity, Institute for Molecular Biosciences, University of Queensland, St. Lucia, Queensland 4072, Australia. r.capon@imb.uq.edu.au
Vuong
Dat
D
Lacey
Ernest
E
Gill
Jennifer H
JH
D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D001622:Betaine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000969:Antinematodal Agents; C498483:echinobetaine A; D001622:Betaine