title: Single-nucleotide polymorphisms in the 17beta-hydroxysteroid dehydrogenase genes might predict the risk of side-effects of estramustine phosphate sodium in prostate cancer patients.
abstract: BACKGROUND
  Estramustine phosphate sodium (EMP) frequently causes side-effects such as gastrointestinal discomfort, nausea, and edema in extremities. We analyzed single nucleotide polymorphisms (SNP) in the 17beta-hydroxysteroid dehydrogenase (HSD17B) genes, which are involved in the metabolism of EMP, to predict the risk of EMP side-effects in prostate cancer patients.
  
  
  METHODS
  We performed genotyping of SNP in the HSD17B genes of 44 Japanese patients with newly diagnosed prostate cancer. The association of SNP and individual EMP side-effects was evaluated.
  
  
  RESULTS
  Peripheral edema occurred more frequently in patients with C/C genotype of IMS-JST123219 than in those with C/G genotype (OR: 5.47, 95% CI: 1.27-23.64). Haplotype analysis showed that appetite loss was associated with the G allele of IMS-JST123219 and the T allele of IMS-JST123218 (OR: 9.13, 95% CI: 1.15-72.76).
  
  
  CONCLUSIONS
  These preliminary data demonstrated that analyses of SNP in the HSD17B genes might predict the occurrence of side-effects from EMP.
authors.affiliation: Department of Urology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. SUZUKIM-URO@h.u-tokyo.ac.jp
authors.forename: Motofumi
authors.initials: M
authors.lastname: Suzuki
authors.forename: Satoru
authors.initials: S
authors.lastname: Muto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ozeki
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yamada
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Tomita
authors.forename: Shuji
authors.initials: S
authors.lastname: Kameyama
authors.forename: Tadaichi
authors.initials: T
authors.lastname: Kitamura
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D001066:Appetite / Q000187:drug effects; D004487:Edema / Q000139:chemically induced; D004961:Estramustine / Q000008:administration & dosage / Q000009:adverse effects*; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D012307:Risk Factors
chemical_list: D018931:Antineoplastic Agents, Hormonal; D004961:Estramustine; D015067:17-Hydroxysteroid Dehydrogenases