A new pinoresinol-type lignan from Ligularia kanaitizensis.
A new pinoresinol-type Lignan, 9alpha-angloyloxypinoresinol (1), was isolated from the roots and rhizomes of Ligularia kanaitizensis (Franch.) Hand.-Mazz, in addition to a known compound, 9alpha-hydroxypinoresinol (2). The structure of this new lignan (1) was established on the basis of 1D and 2D NMR experiments. Anti-HIV-1 RT biological assay showed that 1 was inhibitory to HIV-1 RT.
Li
Yun-Sen
YS
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China. sinodlsia@yahoo.com
Wang
Zheng-Tao
ZT
Zhang
Main
M
Luo
Shi-De
SD
Chen
Ji-Jun
JJ
D019659:Asteraceae / Q000737:chemistry*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy
C497301:9alpha-angloyloxypinoresinol; D005663:Furans; D017705:Lignans; D054303:HIV Reverse Transcriptase