title: Proliferative enteritis associated with Lawsonia intracellularis in a Japanese macaque (Macaca fuscata).
abstract: A 2.5-yr-old, intact male Japanese macaque (Macaca fuscata) was observed to have a thickened ileum during exploratory laparotomy. Lawsonia intracellularis-associated proliferative enteritis was diagnosed using histopathology (Warthin-Starry stain), immunohistochemistry, and polymerase chain reaction analysis of the ileal biopsy. The animal developed transient diarrhea and severe hypoproteinemia 16 days after surgery but recovered with intensive treatment using azithromycin. Given the fact that very specific tests are required for identifying this organism, L. intracellularis may be underdiagnosed in nonhuman primates.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610-0126, USA.
authors.forename: Maud
authors.initials: M
authors.lastname: Lafortune
authors.forename: James F X
authors.initials: JF
authors.lastname: Wellehan
authors.forename: Elliott R
authors.initials: ER
authors.lastname: Jacobson
authors.forename: J Mitchell
authors.initials: JM
authors.lastname: Troutman
authors.forename: Connie J
authors.initials: CJ
authors.lastname: Gebhart
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Thompson
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017963:Azithromycin / Q000627:therapeutic use; D045824:Desulfovibrionaceae Infections / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D004751:Enteritis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D020639:Lawsonia Bacteria / Q000472:pathogenicity*; D008251:Macaca; D008297:Male; D008992:Monkey Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin