Enhanced bone regeneration with a synthetic cell-binding peptide--in vivo results.
This in vivo study compared the regenerative processes within defined defects of the porcine skull after delivery of a porous algae-derived hydroxyapatite (adHA), a similar, experimental adHA carrying the cell binding peptide P-15, used solely and in combination with 25% autogenous bone (AB). Particulated AB served as a control group. During an observation period of 26 weeks, microradiography and histology were performed at four specific times. Significantly higher mineralization rates (p=0.008) were found 4 weeks after application of the bioactive material in combination with AB. At 12 weeks there was a significantly higher mineralization (p=0.036) following the application of the bioactive form alone. This study showed significantly higher mineralization after use of a P-15 bioactivated material at early stages. Thus, it can be concluded that the application of the P-15 sequence to an hydroxyapatite accelerates the process of early bone formation, whereas no long-term effect was traced.
Thorwarth
Michael
M
Department of Maxillofacial Surgery, University Erlangen-Nuremberg, Glueckstrasse 11, D-91054 Erlangen, Germany. michael@thorwarth-online.de
Schultze-Mosgau
Stefan
S
Wehrhan
Falk
F
Srour
Safwan
S
Wiltfang
Joerg
J
Neukam
Friedrich Wilhelm
FW
Schlegel
Karl Andreas
KA
D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000008:administration & dosage* / Q000737:chemistry*; D003094:Collagen / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods; D017102:Fracture Healing / Q000187:drug effects*; D010446:Peptide Fragments / Q000008:administration & dosage*; D012887:Skull Fractures / Q000473:pathology* / Q000628:therapy*; D013552:Swine; D016896:Treatment Outcome
D018786:Bone Substitutes; D010446:Peptide Fragments; C407062:cell-binding peptide P-15; D003094:Collagen