Cationic polyhedral oligomeric silsesquioxane (POSS) units as carriers for drug delivery processes.
Quaternary ammonium functionalized polyhedral oligomeric silsesquioxane (OctaAmmonium-POSS) units, widely employed as additives in ceramic and polymeric systems, possess many attributes which make them attractive as biocompatible drug carriers: nanoscale size, three-dimensional functionality, efficient cellular uptake, low toxicity, and high solubility.
McCusker
Catherine
C
Department of Chemistry, The University of Massachusetts, Amherst, MA 01003, USA.
Carroll
Joseph B
JB
Rotello
Vincent M
VM
D000588:Amines / Q000737:chemistry; D000818:Animals; D019556:COS Cells; D002412:Cations / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D003600:Cytosol / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000737:chemistry* / Q000493:pharmacokinetics*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000493:pharmacokinetics*; D012995:Solubility
D000588:Amines; D002412:Cations; D004337:Drug Carriers; C578915:OctaAmmonium-POSS; D017646:Organosilicon Compounds; D000644:Quaternary Ammonium Compounds