title: New allosteric modulators of metabotropic glutamate receptor 5 (mGluR5) found by ligand-based virtual screening.
authors.affiliation: Johann Wolfgang Goethe-Universität, Institut für Organische Chemie und Chemische Biologie, Marie-Curie-Strasse 11, 60439 Frankfurt am Main, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Renner
authors.forename: Tobias
authors.initials: T
authors.lastname: Noeske
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Parsons
authors.forename: Petra
authors.initials: P
authors.lastname: Schneider
authors.forename: Tanja
authors.initials: T
authors.lastname: Weil
authors.forename: Gisbert
authors.initials: G
authors.lastname: Schneider
mesh_terms: D000495:Allosteric Site; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D016208:Databases, Factual; D004353:Drug Evaluation, Preclinical / Q000379:methods; D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D008024:Ligands; D008297:Male; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D016571:Neural Networks, Computer; D016548:Prosencephalon / Q000378:metabolism; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012995:Solubility
chemical_list: D018691:Excitatory Amino Acid Antagonists; C578937:Grm5 protein, rat; D008024:Ligands; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1; C121465:6-methyl-2-(phenylethynyl)pyridine