title: Synergistic anti-viral effect of oxanosine and ddI against human immunodeficiency virus.
abstract: The combined effect against human immunodeficiency virus (HIV) of oxanosine and 2'3'-dideoxyinosine (ddI) has been evaluated by the production of viral particles, the expression of viral antigens on cell surfaces, and the amount of viral genome integrated in the host cells. Oxanosine alone has no effect on HIV replication up to 100 microg/ml, however, in the presence of ddI, oxanosine revealed concentration dependent inhibition against HIV without cytotoxicity.
authors.affiliation: Department of Microbiology, The Jikei University School of Medicine 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461 Japan. nakamura@jikei.ac.jp
authors.forename: Mariko
authors.initials: M
authors.lastname: Nakamura
authors.forename: Tomoo
authors.initials: T
authors.lastname: Ogawa
authors.forename: Akira
authors.initials: A
authors.lastname: Yokono
authors.forename: Shogo
authors.initials: S
authors.lastname: Nakamori
authors.forename: Tsuneya
authors.initials: T
authors.lastname: Ohno
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umezawa
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D016049:Didanosine / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006678:HIV / Q000187:drug effects* / Q000235:genetics / Q000276:immunology; D006801:Humans; D012263:Ribonucleosides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D012263:Ribonucleosides; C032886:oxanosine; D016049:Didanosine