The ileocyte basolateral organic solute transporter (OSTalpha-OSTbeta) complex: finding the missing link in enterohepatic circulation.
Many drugs are removed from the body through a multistep process that includes covalent conjugation, transport into the bile, and excretion. Bile acids are transported across the ileocyte apical (brush border) membrane by the apical sodium-dependent bile-acid transporter (Asbt), but the identity of the primary transporter responsible for moving bile acids across the basolateral membrane of the ileocyte has remained a mystery, although not for a lack of protein pretenders to the throne. Recent insights from transcriptional profiling studies of wild-type and Asbt-deficient mice indicate that a complex formed by the organic solute carrier proteins alpha and beta (Ostalpha and Ostbeta) is the primary transporter for basolateral bile acid transport.
Gerk
Phillip M
PM
Virginia Commonwealth University School of Pharmacy, Department of Pharmaceutics, Richmond, VA 23298-0533, USA.
Vore
Mary
M
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D001692:Biological Transport; D004285:Dogs; D004764:Enterohepatic Circulation / Q000502:physiology*; D006801:Humans; D007082:Ileum / Q000166:cytology* / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D051379:Mice
D001647:Bile Acids and Salts; D026901:Membrane Transport Proteins