title: Sol-gel processing of drug delivery materials and release kinetics.
abstract: Silica, calcium (5 mol%) silicate and silica/polycaprolactone hybrid inorganic/organic amorphous materials, all mixed with sodium ampicillin, a broad-spectrum antibiotic, have been synthesized by sol-gel method. The amorphous nature of the gels was ascertained by X-ray diffraction analysis. Release kinetics in a simulate body fluid (SBF) have been subsequently investigated. The amount of sodium ampicillin released has been detected by UV-Vis spectroscopy and SEM. The release kinetics seems to occur in more than one stage. Finally FTIR measurements and SEM micrograph showed the formation of a hydroxyapatite layer on the surface of the samples soaked in SBF. All data showed that these materials could be used as drug delivery bioactive systems.
authors.affiliation: Department of Materials and Productions Engineering, University of Naples, Federico II Piazzale Tecchio, 80125 Naples, Italy.
authors.forename: F
authors.initials: F
authors.lastname: De Gaetano
authors.forename: L
authors.initials: L
authors.lastname: Ambrosio
authors.forename: M G
authors.initials: MG
authors.lastname: Raucci
authors.forename: A
authors.initials: A
authors.lastname: Marotta
authors.forename: M
authors.initials: M
authors.lastname: Catauro
mesh_terms: D000667:Ampicillin / Q000737:chemistry / Q000493:pharmacokinetics*; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids; D017610:Calcium Compounds / Q000737:chemistry; D016503:Drug Delivery Systems; D005782:Gels / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D017640:Silicates / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013499:Surface Properties; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D017610:Calcium Compounds; D005782:Gels; D007783:Lactones; D017640:Silicates; D012822:Silicon Dioxide; D000667:Ampicillin; C031293:calcium silicate
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