title: [Structure, function and modulation of actin-related protein 2/3 complex].
abstract: Microfilaments, composed of global actins, involve in many important physiological activities, such as the maintenance of cell shape and cell migration. Actin-related protein 2/3 ( Arp2/3) complex plays a key role in microfilament formation. Actin-related protein 2/3 ( Arp2/3 ) complex which is composed of seven different subunits is subjected to the modulation of many nucleation promoting factors (NPFs) and cooperates with these factors to regulate the actin nucleation. The study of the structure, function and modulation of Arp2/3 complex is important in understanding the mechanism of the formation of microfilament and the interaction between cytoskeleton and signaling molecules.
authors.affiliation: Department of Pathophysiology of the First Military Medical University.
authors.forename: Xio-Wei
authors.initials: XW
authors.lastname: Gong
authors.forename: Yong
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000818:Animals; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D016200:Maturation-Promoting Factor / Q000502:physiology; D008840:Microfilament Proteins / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction
chemical_list: C495926:ACTR2 protein, human; C495928:ACTR3 protein, human; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D003598:Cytoskeletal Proteins; D008840:Microfilament Proteins; D016200:Maturation-Promoting Factor