Highly enantioselective dynamic kinetic resolution and desymmetrization processes by cyclocondensation of chiral aminoalcohols with racemic or prochiral delta-oxoacid derivatives.
Cyclocondensation reactions of aminoalcohols and with racemic or prochiral delta-oxoacid derivatives provide polysubstituted lactams with high enantioselectivity in a process that involves dynamic kinetic resolution and/or desymmetrization of enantiotopic or diastereotopic ester groups.
Amat
Mercedes
M
Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain. amat@ub.edu
Bassas
Oriol
O
Pericàs
Miquel A
MA
Pastó
Mireia
M
Bosch
Joan
J