Association of a genetic polymorphism of the E-cadherin gene with prostate cancer in a Japanese population.
The E-cadherin gene has been identified as having a physiological role in cellular attachment, and is hypothesized to participate in carcinogenesis. A polymorphism (an A to C substitution) in the 5'-untranslated region has a direct effect on E-cadherin gene transcriptional regulation. We explored the association between E-cadherin gene polymorphism and the risk of prostate cancer in a Japanese population. The subjects consisted of 236 patients with prostate cancer, 209 benign prostatic hyperplasia (BPH) patients and 139 male controls. A marginally significant difference was found between prostate cancer patients and male controls (P = 0.053). No significant difference was observed between prostate cancer and BPH patients. When patients with prostate cancer were divided into two groups, stage A+B and stage C+D, a significant difference was observed between progressive cancer patients (stage C+D) and male controls (odds ratio = 1.93, P = 0.016). It is possible that the presence of one A allele resulted in an increased risk of cancer progression.
Kamoto
Toshiyuki
T
Department of Urology, Kyoto University Graduate School of Medicine, Shogoin Kawahara-cho 54, Sakyo-ku, Kyoto City, Kyoto 606-8507, Japan.
Isogawa
Yoshiaki
Y
Shimizu
Yousuke
Y
Minamiguchi
Sachiko
S
Kinoshita
Hidefumi
H
Kakehi
Yoshiyuki
Y
Mitsumori
Kenji
K
Yamamoto
Shingo
S
Habuchi
Tomonori
T
Kato
Tetsuro
T
Ogawa
Osamu
O
D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data; D015820:Cadherins / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011470:Prostatic Hyperplasia / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors
D015820:Cadherins