Laminarin enhanced immunological disorders of septicimeric albino rats infected with Aeromonas hydrophila.
Aeromonas hydrophila is increasingly recognized as a pathogen of man that gives rise to both intestinal and extraintestinal infection. This study examined the effect of one the immunostimulants; fungal cell-wall beta-1, 3-D-glucan (Laminarin) on the immune response to Aeromonas hydrophila in albino rats. Intraperitoneal injection of 0.2 ml of 1% laminarin (15 mg/100 g b.wt) stimulated humoral immunity. On the ninth day, after application of laminarin in vivo, a statistically higher value of total Ig (p < 0.05) was observed. At the same time, serum total immunoglobulins (25.5 +/- 2) g/L in bacterial groups were significantly higher (p < 0.05), compared to the control group (17 +/- 2) g/L. For Aeromonas infected group, all Ig classes showed increase statistically significant (p < 0.05). On the other hand laminarin groups exhibited reduced values of Ig subclasses but still higher than control values. This was reported for all time period. Rats were divided into 3 equal groups designated, Aeromonas infected, Laminarin-treated and control groups. Infection was carrid out by intraperitoneal injection of 2 x 10(6) bacteria daily for 6 days.
Awad
Ezzat M
EM
Departments of Zoology, Faculty of Science, Minia University, El-Minia, Egypt.
Osman
Osman A
OA
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D016980:Aeromonas hydrophila / Q000276:immunology / Q000472:pathogenicity; D000818:Animals; D016470:Bacteremia / Q000209:etiology / Q000276:immunology*; D002473:Cell Wall / Q000276:immunology; D005658:Fungi / Q000276:immunology; D005936:Glucans; D016905:Gram-Negative Bacterial Infections / Q000209:etiology / Q000276:immunology*; D007136:Immunoglobulins / Q000096:biosynthesis / Q000097:blood / Q000145:classification; D008297:Male; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats
D000276:Adjuvants, Immunologic; D005936:Glucans; D007136:Immunoglobulins; D011134:Polysaccharides; C008247:laminaran