Screening of some medicinal plants for anti-lipase activity.
In order to find new pancreatic lipase (triacylglycerol lipase, EC 3.1.1.3) inhibitors from natural sources, 75 medicinal plants belonging to different families were screened for their anti-lipase activity, using a radioactive method. On evaluating the results, methanolic extracts of three plants namely, Eriochloa villosa (Thunb.) Kunth, Orixa japonica Thunb. and Setaria italica (L.) Palib., exhibited strong in vitro anti-lipase activity (above 80%). These plants will be studied further to elucidate the structure and chemical properties of the active compound responsible for anti-lipase action.
Sharma
Niti
N
Applied Biotechnology Laboratory, Department of Biology, College of Natural Science, Kongju National University, Kongju 314-701, Korea.
Sharma
Vinay K
VK
Seo
Sung-Yum
SY
D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures; D010946:Plants, Medicinal; D013552:Swine
D004791:Enzyme Inhibitors; D010936:Plant Extracts; D008049:Lipase