Preparation of various solid-lipid beads for drug delivery of enrofloxacin.
Solid-lipid beads were prepared to retard the release rate of enrofloxacin and to mask its bitter taste using carrageenan or sodium alginate as a shell material and either cacao butter or Witepsol W-35 as a solid lipid core. Sodium alginate was a better shell material than carrageenan and the highest loading efficiency was obtained using 2% sodium alginate. The alginate beads had a spherical morphology and a sturdy shell structure. The enrofloxacin release rate at room temperature was greatly reduced. Solid-lipid beads have the potential to mask the bitter taste of enrofloxacin and extend its release rate.
Kim
Eun-Hee
EH
College of Pharmacy, Chosun University, Gwangju, Korea.
Choi
Hoo-Kyun
HK
D016503:Drug Delivery Systems / Q000379:methods*; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000008:administration & dosage* / Q000138:chemical synthesis*; D008081:Liposomes; D010316:Particle Size; D015363:Quinolones / Q000008:administration & dosage* / Q000138:chemical synthesis*
D024841:Fluoroquinolones; D008081:Liposomes; D015363:Quinolones; D000077422:Enrofloxacin