title: Influence of ischemia on heart-rate variability in chronic hemodialysis patients.
abstract: BACKGROUND
  Sudden cardiac death occurring in patients with end-stage renal disease (ESRD) may be related to poor autonomic function with a significant decreased heart-rate variability (HRV). In addition, coronary artery disease has a high prevalence in this population and accounts for 50% of deaths. In the present study, relationships between HRV and myocardial ischemic abnormalities revealed by myocardial scintigraphy (MS) were evaluated in 32 chronic hemodialysis patients.
  
  
  METHODS
  We prospectively studied 32 chronic hemodialysis patients. Each underwent MS and 24 h electrocardiography at baseline for analysis of time and frequency domain the day of dialysis. Three periods were analyzed: during dialysis session, the morning after (nondialytic period), and in a 24 h period. Patients were included in group 1 (seven women, 11 men; mean age: 62+/-19 years) when MS revealed no ischemia, whereas patients were included in group 2 (seven women, seven men; mean age: 63.1+/-20 years) when MS revealed ischemic lesions.
  
  
  RESULTS
  A student+/-test revealed that during the nondialytic period, two important markers of HRV, percentage of delta RR>50 ms (pNN50) (4.5+/-4.04 in group 1 versus 1.7+/-1.4 in group 2), and root mean square of delta RR (rMSSD) (27.7+/-13.4 versus 19.7+/-6.8) were significantly reduced in group 2 compared with values in group 1. No significant difference appears between the two groups for standard deviation of normal to normal intervals (SDNN), mean heart rate, and spectral analysis.
  
  
  CONCLUSIONS
  Patients with ESRD and myocardial ischemia revealed by MS have reduced parasympathetic activity during the nondialytic period. Correlations between parameters of HRV and ischemic lesions revealed by MS have been shown for the first time.
authors.affiliation: Departement de néphrologie, Center Hospitalier Universitaire, Dijon Cedex, France. isaline.coquet@chu-dijon.fr
authors.forename: Isaline
authors.initials: I
authors.lastname: Coquet
authors.forename: Christiane
authors.initials: C
authors.lastname: Mousson
authors.forename: Gerard
authors.initials: G
authors.lastname: Rifle
authors.forename: Gabriel
authors.initials: G
authors.lastname: Laurent
authors.forename: Daniel
authors.initials: D
authors.lastname: Moreau
authors.forename: Yves
authors.initials: Y
authors.lastname: Cottin
authors.forename: Marianne
authors.initials: M
authors.lastname: Zeller
authors.forename: Claude
authors.initials: C
authors.lastname: Touzery
authors.forename: Jean Eric
authors.initials: JE
authors.lastname: Wolf
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D011446:Prospective Studies; D011877:Radionuclide Imaging; D006435:Renal Dialysis