title: Leucopenia and thrombocytopenia possibly associated with lamotrigine use in a patient.
abstract: Haematological side effects are rather exceptional with lamotrigine. We report the case of a 25-year-old woman with epilepsy who developed combined leucopenia and thrombocytopenia eight weeks after starting lamotrigine. Within weeks after lamotrigine was discontinued, all of the haematopoietic abnormalities had disappeared. To our knowledge, this is the first report of combined leucopenia and thrombocytopenia associated with lamotrigine treatment suggesting, in our patient, a causal reaction.
authors.affiliation: Department of Haematology, Medical and Cancer Research Center, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey. aural@gata.edu.tr
authors.forename: Ali Ugur
authors.initials: AU
authors.lastname: Ural
authors.forename: Ferit
authors.initials: F
authors.lastname: Avcu
authors.forename: Zeki
authors.initials: Z
authors.lastname: Gokcil
authors.forename: Oral
authors.initials: O
authors.lastname: Nevruz
authors.forename: Turker
authors.initials: T
authors.lastname: Cetin
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced* / Q000150:complications; D010976:Platelet Count; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications; D014227:Triazines / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine