Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options.
Apart from complete and incomplete congenital heart block (CHB), new cardiac manifestations related to anti-SSA/Ro antibodies have been reported in children born to mothers bearing these antibodies. These manifestations include transient fetal first-degree heart block, prolongation of corrected QT (QTc) interval, sinus bradycardia, late-onset cardiomyopathy, endocardial fibroelastosis and cardiac malformations. Anti-SSA/Ro antibodies are not considered pathogenic to the adult heart, but a prolongation of the QTc interval has recently been reported in adult patients and is still a matter of debate. Treatment of CHB is not well established and needs to be assessed carefully. The risks and benefits of prenatal fluorinated steroids are discussed.
Costedoat-Chalumeau
Nathalie
N
Service de Médecine Interne, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France. nathalie.costedoat@psl.ap-hop-paris.fr
Amoura
Zahir
Z
Villain
Elisabeth
E
Cohen
Laurence
L
Piette
Jean-Charles
JC
D000328:Adult; D017668:Age of Onset; D000974:Antibodies, Antinuclear / Q000276:immunology*; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology; D001623:Betamethasone / Q000627:therapeutic use; D001919:Bradycardia / Q000209:etiology / Q000276:immunology; D009202:Cardiomyopathies / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003907:Dexamethasone / Q000627:therapeutic use; D004562:Electrocardiography; D004695:Endocardial Fibroelastosis / Q000209:etiology / Q000276:immunology; D005260:Female; D005318:Fetal Heart / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D006327:Heart Block / Q000151:congenital / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D006330:Heart Defects, Congenital / Q000209:etiology / Q000276:immunology; D006331:Heart Diseases / Q000151:congenital / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007223:Infant; D007231:Infant, Newborn; D008133:Long QT Syndrome / Q000151:congenital / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000151:congenital / Q000209:etiology / Q000276:immunology; D008297:Male; D015337:Multicenter Studies as Topic; D009206:Myocardium / Q000276:immunology / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000276:immunology; D011446:Prospective Studies
D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; D003907:Dexamethasone; D001623:Betamethasone
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