Treatment effect of sibutramine compared to fluoxetine on leptin levels in polycystic ovary disease.
Weight reduction on its own is observed to cause improvement in some of the abnormalities seen in patients with polycystic ovary syndrome (PCOS). With respect to this observation, we studied the possible effects of different serotonin reuptake inhibitors (fluoxetine and sibutramine) on serum leptin levels that might play a role in the obesity component seen in patients with PCOS. In a random design, sixteen patients were assigned to fluoxetine and sibutramine for a period of 10 days. In both treatment groups, no significant differences were observed between pre-treatment and post-treatment values in insulin levels (p > 0.05). There was no significant difference between pretreatment and post-treatment serum leptin levels in the fluoxetine treatment group (p > 0.05). However, a significant reduction was observed in the serum leptin levels at the end of treatment in the sibutramine group (p < 0.05). The observed difference in the serum leptin response to the treatment effect of sibutramine compared to fluoxetine seems to be due to a mechanism independent of serotonin reuptake inhibition, possibly to the thermogenic effect of the sibutramine itself. Further studies with larger groups are warranted, to examine the mechanism of the weight-reducing effect of sibutramine. Detailed analyses of basal metabolic activity and change in serum leptin levels should be carried out.
Karabacak
I Y N I
IY
Department of Nuclear Medicine, Gazi University Medical Faculty, Ankara, Turkey. iyetkin@tr.net
Karabacak
O
O
Törüner
F B
FB
Akdemir
O
O
Arslan
M
M
D000328:Adult; D001067:Appetite Depressants / Q000627:therapeutic use; D015992:Body Mass Index; D003503:Cyclobutanes / Q000627:therapeutic use*; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D005640:Follicle Stimulating Hormone / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D020738:Leptin / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D001067:Appetite Depressants; D003503:Cyclobutanes; D005473:Fluoxetine; D005640:Follicle Stimulating Hormone; D020738:Leptin; D007986:Luteinizing Hormone; D017367:Selective Serotonin Reuptake Inhibitors; C058254:sibutramine