Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin.
Nine inositol tripyrophosphate (ITPP) salts have been synthesized. Their ability to act as allosteric effectors of haemoglobin (Hb) has been measured in vitro with free Hb and whole blood. All the synthesized compounds bound to free Hb and were also able to cross, to a certain extent, the plasma membrane of the red blood cells (RBCs) in whole blood samples, lowering the affinity of Hb for oxygen. The oxy-haemoglobin dissociation curves were significantly shifted towards higher values of oxygen partial pressures, both for free Hb and for intracellular Hb in whole blood.
Fylaktakidou
Konstantina C
KC
Laboratoire de Chimie Supramoléculaire, ISIS-Université Louis Pasteur, 8, Allée Gaspard Monge, BP 70028, 67083 Strasbourg cedex, France.
Lehn
Jean-Marie
JM
Greferath
Ruth
R
Nicolau
Claude
C
D000494:Allosteric Regulation; D000818:Animals; D004910:Erythrocyte Membrane / Q000378:metabolism; D006454:Hemoglobins / Q000737:chemistry / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology; D010108:Oxyhemoglobins / Q000737:chemistry
D006454:Hemoglobins; D007295:Inositol Phosphates; D010108:Oxyhemoglobins; C516441:inositol trispyrophosphate