Araloside A, an antiulcer constituent from the root bark of Aralia elata.
Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibited significant reduction of HCl.ethanol-induced gastric lesions and aspirin-induced gastric ulcers at oral doses of 50 and 100 mg/kg, respectively. These activities are comparable to those of cimetidine.
Lee
Eun Bang
EB
Natural Products Research Institute and College of Pharmacy, Seoul National University, Yeongun-dong, Chongno-ku, Seoul, Korea. eblee@snu.ac.kr
Kim
Oon Ja
OJ
Kang
Sam Sik
SS
Jeong
Choonsik
C
D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D027983:Aralia; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D017207:Rats, Sprague-Dawley; D012503:Saponins / Q000302:isolation & purification / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D012503:Saponins; D009828:Oleanolic Acid; C071578:araloside A