title: [Selective serotonin and noradrenaline reuptake inhibitors: a step forward in the treatment of depression?].
abstract: With the tricyclics, selective serotonin reuptake inhibitors (SSRIs) and other substances, we now have available a range of medications for the treatment of depression and other psychological disorders (e.g. anxiety, panic). Nevertheless, only some of the patients experience a remission of their depressive symptoms. The occurrence of side effects and the only modest level of effectiveness result in inadequate compliance on the part of the patient. With venlafaxine and duloxetine two representatives of the selective serotonin and noradrenaline reuptake inhibitor (SSNRI) class of antidepressants are now available. SSNRIs have a dual effect coupled with high selectivity. The present article the extent to which this particular action mechanism results in an improved clinical efficacy and tolerability profile of the SSNRIs, in particular in comparison with SSRIs.
authors.affiliation: Psychiatrische Klinik der Ludwig-Maximilians-Universität München. Hans-Juergen.Moeller@med.uni-muenchen.de
authors.forename: H J
authors.initials: HJ
authors.lastname: Möller
authors.forename: M
authors.initials: M
authors.lastname: Bauer
authors.forename: J
authors.initials: J
authors.lastname: Fritze
authors.forename: E
authors.initials: E
authors.lastname: Haen
authors.forename: G
authors.initials: G
authors.lastname: Laux
authors.forename: W E
authors.initials: WE
authors.lastname: Müller
authors.forename: E
authors.initials: E
authors.lastname: Rüther
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004338:Drug Combinations; D006801:Humans; D050484:Norepinephrine Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D027981:Symporters / Q000037:antagonists & inhibitors*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D004338:Drug Combinations; D050484:Norepinephrine Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors; D027981:Symporters; C493227:SLC6A2 protein, human