title: 3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells.
abstract: The incorporation of the 1-aryl-5-(4-nitrophenyl)-3-oxo-1,4-pentadienyl group into 3,4-dihydro-1H-naphthalenyl, cyclohexyl, 2,3-dihydro-1H-indenyl and cyclopentyl scaffolds led to the discovery of various compounds with selective toxicity for malignant cells and ability to reverse multidrug resistance.
authors.affiliation: College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK, Canada S7N 5C9. dimmock@skyway.usask.ca
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Dimmock
authors.forename: Umashankar
authors.initials: U
authors.lastname: Das
authors.forename: H Inci
authors.initials: HI
authors.lastname: Gul
authors.forename: Masami
authors.initials: M
authors.lastname: Kawase
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakagami
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Baráth
authors.forename: Imre
authors.initials: I
authors.lastname: Ocsovsky
authors.forename: Joseph
authors.initials: J
authors.lastname: Molnár
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D006801:Humans; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007940:Leukemia L5178 / Q000188:drug therapy; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D007659:Ketones