title: Nonpeptide alpha(v)beta3 antagonists: identification of potent, chain-shortened 7-oxo RGD mimetics.
abstract: Potent, novel 7-oxo alpha(v)beta3 antagonists have been prepared. These antagonists offer decreased plasma protein binding and excellent pharmacokinetic profiles.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. amy_zartman@merck.com
authors.forename: Amy E
authors.initials: AE
authors.lastname: Zartman
authors.forename: Le T
authors.initials: LT
authors.lastname: Duong
authors.forename: Carmen
authors.initials: C
authors.lastname: Fernandez-Metzler
authors.forename: George D
authors.initials: GD
authors.lastname: Hartman
authors.forename: Chih-Tai
authors.initials: CT
authors.lastname: Leu
authors.forename: Thomayant
authors.initials: T
authors.lastname: Prueksaritanont
authors.forename: Gideon A
authors.initials: GA
authors.lastname: Rodan
authors.forename: Sevgi B
authors.initials: SB
authors.lastname: Rodan
authors.forename: Mark E
authors.initials: ME
authors.lastname: Duggan
authors.forename: Robert S
authors.initials: RS
authors.lastname: Meissner
mesh_terms: D000818:Animals; D004285:Dogs; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D039302:Integrin alphaVbeta3 / Q000037:antagonists & inhibitors*; D008956:Models, Chemical; D015394:Molecular Structure; D009842:Oligopeptides; D010024:Osteoporosis / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D006574:Heterocyclic Compounds, 2-Ring; D039302:Integrin alphaVbeta3; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid