[Impaired blood coagulative properties in the early postresuscitation period and their prevention].
Experiments were conducted on 356 non-inbred albino rats that had experienced 8-min clinical death caused by acute hemostasis or mechanical asphyxia. Irrespective of the cause of the clinical death, the authors identified uniform phase coagulative disturbances. They appeared as reactive hypercoagulation occurring during clinical death and progressing within 3 hours after resuscitation, by transforming to hypocoagulation that peaked at hours 6 to 24 hours. On day 3, recurrent hypercoagulation developed. Dalargin and mildronate were found to prevent the activation of the vascular and thrombocytic links of hemostasis and the release of clotting agents.
Dolgikh
V T
VT
Razgonov
F I
FI
Shikunova
L G
LG
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001777:Blood Coagulation; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008297:Male; D008763:Methylhydrazines / Q000627:therapeutic use*; D023421:Models, Animal; D051381:Rats; D012151:Resuscitation; D019851:Thrombophilia / Q000517:prevention & control*
D000975:Antioxidants; D008763:Methylhydrazines; D016308:Enkephalin, Leucine-2-Alanine; C050147:3-(2,2,2-trimethylhydrazine)propionate; C040996:enkephalin-Leu, Ala(2)-Arg(6)-