Lipoxygenase inhibiting constituents from Indigofera hetrantha.
A lignan and two acylphloroglucinols have been isolated from the ethyl acetate soluble fraction of the whole plant of Indigofera hetrantha. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. Compounds 1-3 displayed promising inhibitory potential against enzyme lipoxygenase in concentration-dependent manner.
Aziz-Ur-Rehman
International Centre for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Pakistan.
Malik
Abdul
A
Riaz
Naheed
N
Ahmad
Habib
H
Nawaz
Sarfraz Ahmad
SA
Choudhary
Muhammad Iqbal
MI
D004187:Disaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029883:Indigofera / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009005:Monosaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009281:Naphthalenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C502842:1-((3-methylbutanoyl)phloroglucinyl)-beta-D-glucopyranoside; C502843:1-((pentanoyl)phloroglucinyl)-beta-D-glucopyranoside; D004187:Disaccharides; D016859:Lipoxygenase Inhibitors; D009005:Monosaccharides; D009281:Naphthalenes; C502840:lyoniresinol 4,4'-bis-O-beta-D-glucopyranoside; D010696:Phloroglucinol