Inhaled nitric oxide treatment of patients with pulmonary tuberculosis evidenced by positive sputum smears.
Endogenous nitric oxide (NO) has antimycobacterial properties. We tested the hypothesis that exogenous (inhaled) NO can be safely delivered and can accelerate airway disinfection for pulmonary tuberculosis patients treated with standard therapy. Exogenous NO administered at 80 ppm for 72 h can be safely delivered but does not accelerate airway disinfection.
Long
Richard
R
Department of Medicine, University of Alberta, Room 8325, Aberhart Centre 1, 11402, University Ave., Edmonton, Alberta T6G 2J3, Canada. richard.long@ualberta.ca
Jones
Richard
R
Talbot
James
J
Mayers
Irvin
I
Barrie
James
J
Hoskinson
Michael
M
Light
Bruce
B
D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D009569:Nitric Oxide / Q000008:administration & dosage*; D013183:Sputum / Q000382:microbiology*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
D009569:Nitric Oxide
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