title: Pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis.
abstract: An alkene-bridged mimic of the complex DE-bisthioether-ring system of the antibiotic nisin was prepared in one step from the linear precursor.
authors.affiliation: Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB, Utrecht, The Netherlands.
authors.forename: Nourdin
authors.initials: N
authors.lastname: Ghalit
authors.forename: Dirk T S
authors.initials: DT
authors.lastname: Rijkers
authors.forename: Johan
authors.initials: J
authors.lastname: Kemmink
authors.forename: Cees
authors.initials: C
authors.lastname: Versluis
authors.forename: Rob M J
authors.initials: RM
authors.lastname: Liskamp
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry; D003500:Cyclization; D008956:Models, Chemical; D009561:Nisin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry; D011487:Protein Conformation
chemical_list: D000475:Alkenes; D000900:Anti-Bacterial Agents; D009561:Nisin; C071364:nisin Z