SNP haplotypes in the angiotensin I-converting enzyme (ACE) gene: analysis of Nigerian family data using gamete competition models.
Gamete competition models were used to explore the relationships between 13 ACE gene polymorphisms and plasma ACE concentration in a set of Nigerian families. Several markers in the 5' and 3' regions of the gene were significantly associated with ACE concentration (P < 10(-4)). Multi-locus genotypes comprising different combinations of markers from the 5' UTR and the 3' region of the gene were also analysed; in addition to G2350A, in the 3' region, two markers from the 5' UTR (A-5466C and A-240T) were found to be associated with ACE concentration. These results are consistent with reports that have suggested the presence of at least two ACE-linked QTLs, and demonstrate the utility of gamete competition models in the exploratory investigation of the relationship between a quantitative trait and multiple variants in a small genomic region.
McKenzie
C A
CA
Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica, West Indies. colin.mckenzie02@uwimona.edu.jm
Sinsheimer
J S
JS
Adeyemo
A A
AA
Cox
R D
RD
Southam
L
L
Hugill
A
A
Bouzekri
N
N
Lathrop
M
M
Forrester
T E
TE
Cooper
R S
RS
Ward
R
R
D000328:Adult; D005260:Female; D005854:Germ Cells; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009549:Nigeria; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D007703:Peptidyl-Dipeptidase A