Human papilloma virus in oral squamous cell carcinoma in a Mexican population.
OBJECTIVE
To determine the human papilloma virus (HPV) infection in oral cancer and its association with smoking and drinking habits.


METHODS
A cross-sectional study was performed; samples were collected from 51 patients with histological diagnosis of squamous-cell carcinoma were collected at the Instituto Nacional de Cancerología in Mexico City. HPV infection was detected by polymerase chain reaction, and the clinical characteristics of this population were analyzed.


RESULTS
Fifty samples out of 51 were positive for beta-globin; 21 (42%) cases were HPV-positive, and 14/21 were positive for HPV-16. We found more samples positive in men than in women (71% vs 29%). No differences were observed between HPV-positive and -negative patients in relation to smoking and drinking habits (81% vs 79%).


CONCLUSIONS
HPV infection was present in 42% of patients with oral squamous-cell carcinoma (OSCC); HPV-16 was the most frequent type, identified in 66.6%. Other cofactors participate in the development of OSCC, independent of HPV infection.
Ibieta
Blanca R
BR
Instituto Nacional de Cancerología, Mexico City, Mexico. ibieta2000@hotmail.com
Lizano
Marcela
M
Fras-Mendivil
Mauricio
M
Barrera
José L
JL
Carrillo
Adela
A
Ma Ruz-Godoy
Luz
L
Mohar
Alejandro
A
D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D003430:Cross-Sectional Studies; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification / Q000472:pathogenicity*; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking
D015344:DNA Probes, HPV; D004279:DNA, Viral