title: [Combination chemotherapy with docetaxel and cisplatin in patients with hormone-refractory prostate cancer].
abstract: We investigated the efficacy of docetaxel and cisplatin for hormone-refractory prostate cancer (HRPC). Thirteen patients with HRPC were treated with 30 mg/m2 docetaxel weekly for 3 weeks and 70 mg/m2 cisplatin on day 1. Treatment was repeated every 21 days. They received 2 cycles and were evaluated for the responses to serum prostate-specific antigen (PSA) and tumor size. Ten (77%) of the 13 patients showed a 50% or greater decrease in PSA with a median time to progression of 3 months. One of the 2 patients with measurable soft tissue disease showed a reduction in disease. No severe toxicity of this regimen was observed. Combination chemotherapy with docetaxel and cisplatin in patients with HRPC was well tolerated and efficatious with a significant decrease in serum PSA and measurable disease.
authors.affiliation: The Department of Urology, Kanagawa Cancer Center.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fujinami
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miura
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Takizawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Osada
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077143:Docetaxel; D004334:Drug Administration Schedule; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D000726:Androgen Antagonists; D043823:Taxoids; D000077143:Docetaxel; D004054:Diethylstilbestrol; D017430:Prostate-Specific Antigen; D002945:Cisplatin; C000937:diethylstilbestrol dipropionate