title: US, MRCP, CCT and ERCP: a comparative study in 131 patients with suspected biliary obstruction.
abstract: BACKGROUND
  Recent years have witnessed a rapid and continuous evolution in the diagnosis of biliary obstructive disease. Traditional methodologies, such as US (ultrasonography), CT (computed tomography), ERCP (endoscopic retrograde cholangiopancreatography) and PTC (percutaneous transhepatic cholangiography), have been supplemented by MRCP (magnetic resonance cholagiopancreatography) and CCT (cholangio computed tomography) The purpose of our study was to compare the reliability of diagnostic US, MR and other imaging techniques in intrinsic biliary obstructive disease.
  
  
  METHODS
  Between June 1999 and July 2003 we conducted a prospective study on 131 patients--60 males and 71 females--ranging in age from 37 to 79 years, with clinical features of biliary obstructive disease. Imaging studies were done on each patient using several different techniques. The US, MRCP, CCT and ERCP results were read by radiologists blinded to other imaging findings.
  
  
  RESULTS
  US is generally accurate in diagnostic imaging of obstructive biliary disease. MRCP and CCT are significantly more accurate only in completing the staging of malignant stenosis.
  
  
  CONCLUSIONS
  If the suspicion posed by clinical and laboratory findings is not confirmed at US, the diagnosis must be achieved with the aid of MRCP or--where MRCP does not provide a diagnosis--CCT, so as to select candidates for therapeutic ERCP, PTC or surgery. If laboratory and clinical findings are supported by US, ERCP is required for therapeutic purposes, or--if necessary--surgery is performed.
authors.affiliation: Department of Radiology, University Hospital Siena, Siena, Italy. ferrari@unisi.it
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Ferrari
authors.forename: Federica
authors.initials: F
authors.lastname: Fantozzi
authors.forename: Laura
authors.initials: L
authors.lastname: Tasciotti
authors.forename: Francesco
authors.initials: F
authors.lastname: Vigni
authors.forename: Francesca
authors.initials: F
authors.lastname: Scotto
authors.forename: Paolo
authors.initials: P
authors.lastname: Frasci
mesh_terms: D000328:Adult; D000368:Aged; D001660:Biliary Tract Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002758:Cholangiography; D002760:Cholangiopancreatography, Endoscopic Retrograde; D019160:Endosonography; D005260:Female; D006801:Humans; D007558:Italy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed