Vitamin B2 (riboflavin) and a mixture of vitamin B2 and C affects MMC efficiency in aerated media under irradiation.
Vitamin B2 (Riboflavin) acts as a strong radiation protecting agent in Escherichia coli bacteria (AB1157) in aerated media. This ability is reinforced by the addition of vitamin C. Under the influence of gamma-radiation, vitamin B2 completely suppresses the cytostatic activity of mitomycin C (MMC). In the presence of both vitamins, B2 and C, MMC is converted from an efficient cytostatic to a rather strong radiation protecting agent. This effect opens a new pathway for specific protection of normal mammalian cells (with a high O2-content) under treatment with ionizing radiation.
Fuga
Linda
L
Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, A-1090 Vienna, Austria.
Kragl
Martin
M
Getoff
Nikola
N
D001205:Ascorbic Acid / Q000737:chemistry / Q000494:pharmacology*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D016685:Mitomycin / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism*; D010545:Peroxides / Q000737:chemistry / Q000378:metabolism; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism; D012256:Riboflavin / Q000737:chemistry / Q000494:pharmacology*
D010545:Peroxides; D011837:Radiation-Protective Agents; D017382:Reactive Oxygen Species; C049375:perhydroxyl radical; D016685:Mitomycin; D001205:Ascorbic Acid; D010100:Oxygen; D012256:Riboflavin