title: Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites.
abstract: Thalidomide (Thal: 1) and its two metabolites, 5-hydroxythalidomide (5-HT: 2) and N-hydroxythalidomide (N-HT: 3), showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation. 5-HT and N-HT showed tubulin polymerization-inhibiting activity, but thalidomide did not.
authors.affiliation: Institute of Molecular & Cellular Biosciences, The University of Tokyo, Yayoi, Tokyo, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Noguchi
authors.forename: Chihiro
authors.initials: C
authors.lastname: Shinji
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Makoto
authors.initials: M
authors.lastname: Makishima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyachi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology; D004357:Drug Synergism; D018922:HL-60 Cells; D006801:Humans; D013792:Thalidomide / Q000378:metabolism* / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D013792:Thalidomide; D014212:Tretinoin