title: An overview of controlled studies of anxiety disorders treatment in children and adolescents.
abstract: OBJECTIVE
  Although several treatments for children and adolescents with anxiety disorders are available, there are few well-controlled studies in the literature that compare these treatments for efficacy. The objective of this paper is to provide an overview of controlled treatment studies for children and adolescents with anxiety disorders.
  
  
  METHODS
  The research literature on controlled treatment studies of anxiety disorders in children and adolescents was systematically reviewed through a search of PsycINFO and Medline. Studies that did not compare the efficacy of treatment modalities were excluded.
  
  
  RESULTS
  This review focuses specifically on three main treatment modalities: cognitive-behavioral therapy, both individual and group; family-based interventions; and pharmacotherapy. Each of these modalities is reviewed in the context of the separate disorders as defined by DSM-III-R and/or DSM-IV. The results are especially promising for cognitive-behavioral therapy and pharmacotherapy for many of the anxiety disorders; however, there are concerns about small sample sizes, lack of described comorbidity within the groups and generalizability.
  
  
  CONCLUSIONS
  While great strides have been made in the treatment of child and adolescent anxiety disorders, empirically based studies are quantitatively limited. More research is needed involving head-to-head trials of the different modalities.
authors.affiliation: Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Roxanne W
authors.initials: RW
authors.lastname: Scott
authors.forename: Kess
authors.initials: K
authors.lastname: Mughelli
authors.forename: Deborah
authors.initials: D
authors.lastname: Deas
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000628:therapy*; D001521:Behavior Therapy; D002648:Child; D015928:Cognitive Behavioral Therapy; D018849:Controlled Clinical Trials as Topic; D004358:Drug Therapy; D005196:Family Therapy; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000628:therapy; D010698:Phobic Disorders / Q000628:therapy; D013313:Stress Disorders, Post-Traumatic / Q000628:therapy
references.citation: J Am Acad Child Adolesc Psychiatry. 1999 Oct;38(10):1223-9
references.pmid: 10517054
references.citation: J Am Acad Child Adolesc Psychiatry. 1998 Apr;37(4):404-11
references.pmid: 9549961
references.citation: J Am Acad Child Adolesc Psychiatry. 1998 Oct;37(10):1022-9
references.pmid: 9785713
references.citation: JAMA. 1998 Nov 25;280(20):1752-6
references.pmid: 9842950
references.citation: J Clin Child Psychol. 1998 Dec;27(4):459-68
references.pmid: 9866083
references.citation: J Consult Clin Psychol. 1999 Oct;67(5):675-87
references.pmid: 10535234
references.citation: J Consult Clin Psychol. 1999 Dec;67(6):995-1003
references.pmid: 10596522
references.citation: J Am Acad Child Adolesc Psychiatry. 2000 Mar;39(3):276-83
references.pmid: 10714046
references.citation: J Am Acad Child Adolesc Psychiatry. 2000 Nov;39(11):1347-55
references.pmid: 11068889
references.citation: J Consult Clin Psychol. 2000 Dec;68(6):1072-80
references.pmid: 11142541
references.citation: J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):197-205
references.pmid: 11211368
references.citation: J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):222-9
references.pmid: 11211371
references.citation: J Am Acad Child Adolesc Psychiatry. 2001 Jul;40(7):773-9
references.pmid: 11437015
references.citation: J Clin Child Psychol. 2001 Dec;30(4):525-35
references.pmid: 11708240
references.citation: Am J Psychiatry. 2001 Dec;158(12):2008-14
references.pmid: 11729017
references.citation: Am J Psychiatry. 1988 Aug;145(8):960-4
references.pmid: 3394880
references.citation: J Am Acad Child Adolesc Psychiatry. 1988 Nov;27(6):764-71
references.pmid: 3264280
references.citation: Behav Modif. 1988 Apr;12(2):165-204
references.pmid: 3069092
references.citation: J Am Acad Child Adolesc Psychiatry. 1990 Sep;29(5):753-8
references.pmid: 2228929
references.citation: J Am Acad Child Adolesc Psychiatry. 1992 Jan;31(1):45-9
references.pmid: 1537780
references.citation: J Am Acad Child Adolesc Psychiatry. 1992 Nov;31(6):1062-9
references.pmid: 1429406
references.citation: J Am Acad Child Adolesc Psychiatry. 1993 Jan;32(1):1-6
references.pmid: 8428861
references.citation: J Am Acad Child Adolesc Psychiatry. 1994 Mar-Apr;33(3):333-41
references.pmid: 8169177
references.citation: J Consult Clin Psychol. 1994 Feb;62(1):100-10
references.pmid: 8034812
references.citation: J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug;33(6):782-91
references.pmid: 8083134
references.citation: J Am Acad Child Adolesc Psychiatry. 1995 Oct;34(10):1369-80
references.pmid: 7592275
references.citation: J Am Acad Child Adolesc Psychiatry. 1996 Jan;35(1):42-50
references.pmid: 8567611
references.citation: J Am Acad Child Adolesc Psychiatry. 1996 Jul;35(7):865-77
references.pmid: 8768346
references.citation: J Consult Clin Psychol. 1996 Apr;64(2):333-42
references.pmid: 8871418
references.citation: J Consult Clin Psychol. 1997 Jun;65(3):366-80
references.pmid: 9170760
references.citation: J Am Acad Child Adolesc Psychiatry. 1998 Apr;37(4):395-403
references.pmid: 9549960
references.citation: Child Adolesc Psychiatr Clin N Am. 1999 Jul;8(3):445-60
references.pmid: 10442225