[Progress of RNA interference mechanism].
RNA interference (RNAi) is a phenomenon that the double-stranded RNA (dsRNA) intermediates the degradation of complementary mRNA found in many organisms. This is a specifically mechanism involved in kinds of proteins to complete the interference function. Structure of siRNA affects which strand will be assembled into RISC. Another role of siRNA is directing RITS complex to bind with homologue chromosome, and then induces heterochromatinization. Although systemic silence induced by dsRNA is observed in Caenorhabditis elegans and plants, this progress is probably transmembrane protein-dependent, and mostly, the systemic silencing is controlled by multi-factors.
Yan
Fei
F
State key laboratory for biology of plant diseases and insect pests, Institute of Plant Protection, Chinese Academy of Agricultural Science, Beijing 100094, China. dianyong@263.com
Cheng
Zhuo-Min
ZM
D000818:Animals; D060565:Argonaute Proteins; D017173:Caenorhabditis elegans / Q000235:genetics; D019175:DNA Methylation; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D039642:Eukaryotic Initiation Factors; D006801:Humans; D010944:Plants / Q000235:genetics; D034622:RNA Interference; D012330:RNA, Double-Stranded / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics*; D034743:RNA-Induced Silencing Complex / Q000235:genetics*; D043244:Ribonuclease III / Q000235:genetics / Q000502:physiology
C489654:AGO1 protein, Drosophila; D060565:Argonaute Proteins; D029721:Drosophila Proteins; D039642:Eukaryotic Initiation Factors; D012330:RNA, Double-Stranded; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D034743:RNA-Induced Silencing Complex; D043244:Ribonuclease III