Immunological status in the aetiology of recurrent otitis media with effusion: serum immunoglobulin levels, functional mannose-binding lectin and Fc receptor polymorphisms for IgG.
The objective was to study the role of serum immunoglobulin levels, mannose-binding lectin (MBL), and Fc gamma receptor (FcgammaR) polymorphisms on the development of recurrent otitis media with effusion (OME). Children aged between two and seven years with persisting OME received bilateral tympanostomy tubes and immunological parameters were investigated in relation with OME recurrence within six months after tube extrusion. No statistically significant differences in serum immunoglobulin levels were present between children with and without OME recurrence. In children with bilateral recurrence (n = 56), median levels of MBL were 1.39 mg/L compared to 2.48 mg/L in children with OME recurrence (n = 17) (p = 0.29). In addition, 34% of the children with bilateral recurrence were homozygous for the genotype FcgammaRIIa-R/R131, whereas less than 20% of the children with unilateral recurrence or those without recurrence were homozygous for this Fcgamma receptor (p = 0.26). Serum mannose-binding lectin and FcgammaRIIa-R/R131 polymorphism may play a role in the aetio-pathogenesis of recurrent OME.
Straetemans
Masja
M
Department of Epidemiology and Biostatistics, University Medical Centre Nijmegen, Nijmegen, The Netherlands.
Wiertsema
Selma P
SP
Sanders
Elisabeth A M
EA
Rijkers
Ger T
GT
Graamans
Kees
K
van der Baan
Bert
B
Zielhuis
Gerhard A
GA
D002648:Child; D002675:Child, Preschool; D006720:Homozygote; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology*; D037601:Mannose-Binding Lectin / Q000097:blood*; D010034:Otitis Media with Effusion / Q000235:genetics / Q000276:immunology*; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000097:blood / Q000235:genetics*; D012008:Recurrence
D007074:Immunoglobulin G; D007136:Immunoglobulins; D037601:Mannose-Binding Lectin; D017452:Receptors, IgG
Clin Otolaryngol Allied Sci. 2003 Aug;28(4):335-40
12871248
Arch Otolaryngol. 1970 Oct;92(4):311-24
5455571
JAMA. 2001 Mar 14;285(10):1316-21
11255386
Lancet. 1995 Oct 7;346(8980):941-3
7564730
Clin Infect Dis. 1998 Oct;27(4):746-50
9798027
N Engl J Med. 1987 Dec 3;317(23):1444-51
3683478
Acta Paediatr. 1997 Nov;86(11):1208-13
9401515
Clin Otolaryngol Allied Sci. 1990 Jun;15(3):283-8
2203566
Int J Pediatr Otorhinolaryngol. 1984 Mar;7(1):39-49
6724809
Immunochemistry. 1965 Sep;2(3):235-54
4956917
Wien Klin Wochenschr. 2001 Oct 30;113(20-21):825-31
11732118
Clin Exp Immunol. 1984 May;56(2):233-8
6733969
Immunogenetics. 2003 Jul;55(4):240-6
12830330
Rheumatology (Oxford). 2001 Sep;40(9):1009-12
11561111
Int J Pediatr Otorhinolaryngol. 1998 Aug 1;44(3):227-34
9780068
Clin Exp Immunol. 1999 Jun;116(3):505-8
10361242
J Immunol Methods. 2002 Oct 15;268(2):149-57
12215383
Clin Otolaryngol Allied Sci. 1990 Apr;15(2):147-53
2350892
Neurology. 2000 Sep 12;55(5):705-7
10980740
J Pediatr. 1992 Aug;121(2):249-51
1640291
J Infect Dis. 1994 Oct;170(4):854-61
7930727
Med Hypotheses. 2001 Dec;57(6):784-91
11918448
Am J Med. 2002 Jan;112(1):19-25
11812402
Am J Otol. 1995 May;16(3):365-72
8588632
Ear Hear. 1994 Jun;15(3):224-31
8076720
Clin Exp Immunol. 1993 Oct;94(1):99-104
8403525
J Neuroimmunol. 2003 Jul;140(1-2):210-5
12864991
Blood. 1999 Dec 15;94(12):4220-32
10590067
Baillieres Clin Haematol. 1991 Dec;4(4):889-902
1790356
Ann N Y Acad Sci. 1997 Dec 29;830:70-81
9616668
J Infect Dis. 2001 Dec 15;184(12):1548-55
11740730
Lancet. 2002 May 4;359(9317):1569-73
12047967
Pediatr Rev. 1999 Mar;20(3):85-93; quiz 94
10073070
Int J Pediatr Otorhinolaryngol. 1999 Mar 15;47(3):243-51
10321779
Immunogenetics. 1998 Aug;48(3):222-32
9683667
Scand J Infect Dis. 1999;31(4):363-6
10528874
Lancet. 1991 Jun 29;337(8757):1569-70
1675710