[Effects of intranasal cortocosteroidson on the expression of Aquaporin-5 in human nasal polyps].
OBJECTIVE
To observe the effects of intranasal Fluticasone propionate on the expression of Aquaporin-5 in nasal polyps and explore the role of AQP-5 in the formation of nasal polyps.


METHODS
Twenty cases of nasal polyps were selected. Fluticasone propionate were intranasally used in 10 cases of nasal polyps for 7-10 days before operation. The others, treated with nothing, were used as control. Twenty samples nasal polyps were obtained and studied with immunochemistric technique.


RESULTS
The expression of AQP-5 positive cells in the blood vessel endothelium was statistically significantly redueced in the Fluticasone propionate-using group compared with the control group (P < 0.05). The difference of AQP-5 positive cells in mucosal epithelial and glandular epithelium was not statistically significant between the Fluticasone propionate-using group and the control group.


CONCLUSIONS
(1) AQP-5 might be a vital factor for the formation edema of nasal polyps. (2) The effects of Fluticasone propionate on nasal polyps may be related to changing the expression of AQP-5 to a degree. (3) The full exploration of regulation and control of Aquaporions can contribute to evaluate the pathogenesis of nasal polyps.
Li
Zhihai
Z
Department of Otolaryngology, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, 430030, China.
Gao
Qixue
Q
Zhen
Hongtao
H
Cui
Yonghua
Y
D000281:Administration, Intranasal; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051402:Aquaporin 5 / Q000096:biosynthesis*; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy / Q000378:metabolism*
D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D051402:Aquaporin 5; D000068298:Fluticasone