Modulation of the notch pathway for immunotherapy.
Since its initial description as a neurogenic locus in Drosophila, the Notch pathway has been shown to play a central role in cell fate decisions across species, including vertebrates, guiding the differentiation of multiple cell types. In the immune system, its function was first demonstrated during lymphopoiesis, but in recent years this pathway has been shown to still be active in peripheral T-cells. Therapeutic opportunities that could arise from the manipulation of Notch signaling in immune disorders such as autoimmunity, allergy and in cancer immunotherapy and transplantation are discussed.
Briend
Emmanuel
E
Lorantis Ltd, Cambridge, UK. emmanuel.briend@lorantis.com
Young
Lesley L
LL
McKenzie
Grahame J
GJ
Tugal
Tamara
T
Ragno
Silvia
S
Champion
Brian R
BR
D000818:Animals; D004247:DNA; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000276:immunology; D007167:Immunotherapy; D008024:Ligands; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology / Q000502:physiology* / Q000627:therapeutic use; D051880:Receptors, Notch; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D014612:Vaccines / Q000276:immunology / Q000627:therapeutic use
D008024:Ligands; D008565:Membrane Proteins; D051880:Receptors, Notch; D014612:Vaccines; D004247:DNA