title: Clinicopathologic study of non-Hodgkin lymphoma in sinonasal and hard palate regions in 15 Japanese cases.
abstract: Non-Hodgkin lymphomas of the sinonasal region have been the subject of numerous studies. Previous reports have suggested that nasal lymphomas occurring in Orientals are mostly of the natural killer cell (NK)/T-cell phenotype which contrasts with the preponderance of the B-cell type in western populations. Recent studies indicated that NK/T-cell lymphoma constitutes the clinical condition of lethal midline granuloma. These reports led us to question whether all NK/T lymphomas are always lethal midline granuloma. We have investigated a series of 15 cases of non-Hodgkin lymphomas in the nasal and/or paranasal sinuses clinically, immunohistochemically and for the presence of Epstein-Barr virus (EBV). This study showed that the presence of EBV was common in nasal NK/T lymphoma, and this type of lymphoma was clearly highly frequent in other types of nasal lymphoma in our department. Moreover, in 4 cases of NK/T-cell lymphomas, the clinical features of lethal midline granuloma did not appear, indicating that NK/T lymphomas are not always lethal midline granuloma.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Oral Surgery, Kyorin University School of Medicine, Mitaka City, Japan. t-michi-twin@k3.dion.ne.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ikeda
authors.forename: Takeo
authors.initials: T
authors.lastname: Kanaya
authors.forename: Akifumi
authors.initials: A
authors.lastname: Matsuda
authors.forename: Kenichi
authors.initials: K
authors.lastname: Motohashi
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tanaka
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kohno
authors.forename: Sigeru
authors.initials: S
authors.lastname: Kamiya
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Fujioka
authors.forename: Ryo
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Fumio
authors.initials: F
authors.lastname: Mizuno
authors.forename: Makoto
authors.initials: M
authors.lastname: Hasegawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018951:Antigens, CD20 / Q000276:immunology; D001859:Bone Neoplasms / Q000276:immunology / Q000473:pathology* / Q000532:radiotherapy*; D017252:CD3 Complex / Q000276:immunology; D019002:CD56 Antigen / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007564:Japan; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000473:pathology* / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D021362:Palate, Hard / Q000276:immunology / Q000473:pathology* / Q000528:radiation effects*; D010255:Paranasal Sinus Neoplasms / Q000276:immunology / Q000473:pathology* / Q000532:radiotherapy*; D011879:Radiotherapy Dosage
chemical_list: D018951:Antigens, CD20; D017252:CD3 Complex; D019002:CD56 Antigen