Novel beta-(imidazol-4-yl)-beta-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I.
Solid-phase synthesis of imidazolyl-beta-amino acid derivatives is described. Several analogs demonstrated moderate inhibition of geranylgeranyl protein transferase type I (GGPT I).
Saha
Ashis K
AK
Janssen Research Foundation, Welsh & McKean Roads, Spring House, PA 19477, USA. Ashis.Saha@praecis.com
End
David W
DW
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000596:Amino Acids; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I