title: Diagnostic accuracy of 16-row multislice CT angiography in the evaluation of coronary segments.
abstract: OBJECTIVE
  To evaluate the diagnostic accuracy of 16-row multislice spiral computed tomography coronary angiography (16-MSCT-CA) for the non-invasive assessment of significant coronary artery stenosis.
  
  
  METHODS
  We enrolled 40 patients (36 male, aged 59+/-11 yrs) with suspected obstructive coronary artery disease and a heart rate <65 bpm during the scan. The 16-MSCT-CA (Sensation 16, Siemens, Forchheim, Germany) was performed with electrocardiographically-gated technique after the intravenous administration of 100 ml of iodinated contrast material followed by a saline bolus chaser. The scan parameters were: collimation 16 x 0.75 mm, rotation time 0.42 s, feed/rot. 3 mm (pitch 0.25), 120 kVp, 500 mAs. All coronary segments = or >2 mm in diameter were evaluated by two independent observers for the presence of significant coronary artery stenosis (= or >50%). Consensus reading was compared to quantitative coronary angiography.
  
  
  RESULTS
  The average heart rate was 55+/-6 bpm. Of the 428 segments of = or >2.0 mm diameter 92 were significantly diseased. Without exclusion of any branches (428), the sensitivity, specificity, positive, and negative predictive values to identify = or >50% obstructed segments were 95.7% (88/92), 95.8% (322/336), 86.3% (88/102), and 98.8% (322/326), respectively. No occluded left main, left anterior descending, circumflex or right coronary artery segments remained undetected.
  
  
  CONCLUSIONS
  16-MSCT-CA in a selected low-heart-rate patient population provides high diagnostic accuracy in the evaluation of significant coronary artery stenosis.
authors.affiliation: Dipartimento di Radiologia, Erasmus Medical Center, Rotterdam, The Netherlands. filippocademartiri@hotmail.com
authors.forename: F
authors.initials: F
authors.lastname: Cademartiri
authors.forename: G
authors.initials: G
authors.lastname: Runza
authors.forename: R
authors.initials: R
authors.lastname: Marano
authors.forename: G
authors.initials: G
authors.lastname: Luccichenti
authors.forename: M
authors.initials: M
authors.lastname: Gualerzi
authors.forename: L
authors.initials: L
authors.lastname: Brambilla
authors.forename: M
authors.initials: M
authors.lastname: Galia
authors.forename: G P
authors.initials: GP
authors.lastname: Krestin
authors.forename: P
authors.initials: P
authors.lastname: Coruzzi
authors.forename: M
authors.initials: M
authors.lastname: Midiri
authors.forename: M
authors.initials: M
authors.lastname: Belgrano
mesh_terms: D003287:Contrast Media; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed
chemical_list: D003287:Contrast Media