Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection.
To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infection spontaneously. Acute-phase CD4 responses were efficient in self-limited infections but undetectable in the coinfected patient with HBV persistence. CD8 responses were multispecific irrespective of the outcome of infection, but the CD8 repertoire associated with HBV persistence lacked the most dominant specificities detectable in self-limited infections. In conclusion, insufficient CD4 help and defective CD8 repertoire may play a role at the early stages of infection in influencing HBV persistence.
Urbani
Simona
S
Laboratory of Viral Immunopathology, Division of Infectious Diseases and Hepatology, Azienda Ospedaliera di Parma, 43100 Parma, Italy.
Boni
Carolina
C
Amadei
Barbara
B
Fisicaro
Paola
P
Cerioni
Simona
S
Valli
Maria Antonietta
MA
Missale
Gabriele
G
Ferrari
Carlo
C
D000210:Acute-Phase Reaction / Q000276:immunology*; D000917:Antibody Formation; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D018450:Disease Progression; D000939:Epitopes / Q000276:immunology; D015789:HLA-A2 Antigen / Q000097:blood / Q000276:immunology; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000276:immunology* / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000209:etiology / Q000276:immunology; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007111:Immunity, Cellular; D013601:T-Lymphocytes / Q000276:immunology; D019562:Viral Load
D000939:Epitopes; D015789:HLA-A2 Antigen; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens