title: Catastrophic antiphospholipid syndrome in a 14-year-old child.
abstract: Antiphospholipid syndrome (APS) is an autoimmune disease. Less than 1% of patients with APS present with life-threatening catastrophic APS (CAPS). We report here a case of CAPS in a young girl with cardiac, gastrointestinal and renal involvement. Although the management was complicated, the outcome was better than expected. We suggest that CAPS be included in the differential diagnosis of acute renal failure in children with multi-organ involvement and prolonged phospholipid-dependent coagulation time and promptly treated with immunomodulating agents and anticoagulants.
authors.affiliation: Department of Nephrology, General Hospital of Athens, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Tsirpanlis
authors.forename: George
authors.initials: G
authors.lastname: Moustakas
authors.forename: Eleni
authors.initials: E
authors.lastname: Sakka
authors.forename: George
authors.initials: G
authors.lastname: Triantafyllis
authors.forename: Flora
authors.initials: F
authors.lastname: Sotsiou
authors.forename: Helen
authors.initials: H
authors.lastname: Liapis
authors.forename: Panos
authors.initials: P
authors.lastname: Ziroyannis
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology; D000293:Adolescent; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D002388:Catastrophic Illness / Q000628:therapy*; D003937:Diagnosis, Differential; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008854:Microscopy, Electron; D009205:Myocarditis / Q000209:etiology
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