title: Personality and comorbidity of common psychiatric disorders.
abstract: BACKGROUND
  We know little about the degree to which comorbidity, socommonly seen among psychiatric disorders, arises from variation in normal personality.
  
  
  OBJECTIVE
  To study the degree to which variation in normal personality accounts for the comorbidity of eight common psychiatric and substance use disorders.
  
  
  METHODS
  Internalising disorders (major depression, generalised anxiety and panic disorders, phobias), externalising disorders (alcohol and drug dependence, antisocial personality and conduct disorders) and personality dimensions of neuroticism, extraversion and novelty seeking were assessed in 7588 participants from a population-based twin registry. The proportion of comorbidity explained by each personality dimension was calculated using structural equation modelling.
  
  
  RESULTS
  Neuroticism accounted for the highest proportion of comorbidity within internalising disorders (20-45%) and between internalising and externalising disorders (19-88%). Variation in neuroticism and novelty seeking each accounted for a modest proportion (10-12% and 7-14%, respectively) of the comorbidity within externalising disorders. Extraversion contributed negligibly.
  
  
  CONCLUSIONS
  High neuroticism appears to be a broad vulnerability factor for comorbid psychiatric disorders. Novelty seeking is modestly important for comorbid externalising disorders.
authors.affiliation: Mental Health and Behavioral Sciences Service, Providence VA Medical Center, 830 Chalkstone Ave., Providence, RI 02908, USA. amir.khan2@med.va.gov
authors.forename: Amir A
authors.initials: AA
authors.lastname: Khan
authors.forename: Kristen C
authors.initials: KC
authors.lastname: Jacobson
authors.forename: Charles O
authors.initials: CO
authors.lastname: Gardner
authors.forename: Carol A
authors.initials: CA
authors.lastname: Prescott
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Kendler
mesh_terms: D000328:Adult; D015897:Comorbidity; D017831:Diagnosis, Dual (Psychiatry); D004200:Diseases in Twins / Q000453:epidemiology* / Q000523:psychology; D005106:Exploratory Behavior; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology* / Q000523:psychology; D008875:Middle Aged; D009497:Neurotic Disorders / Q000453:epidemiology; D010551:Personality; D015995:Prevalence; D012737:Sex Factors; D019966:Substance-Related Disorders / Q000453:epidemiology; D014768:Virginia / Q000453:epidemiology