title: The effect of autologous serum eyedrops in the treatment of severe dry eye disease: a prospective randomized case-control study.
abstract: OBJECTIVE
  To evaluate the effectiveness of the autologous serum eyedrops in the treatment of severe dry eye patients.
  
  
  METHODS
  Prospective randomized case-control study.
  
  
  METHODS
  Thirty-seven eyes of twenty severe dry eye patients without punctal occlusion were enrolled in this study. After 2 weeks of washout, they were randomly assigned to two groups. Group A patients used only preservative-free artificial tears, and group S patients used only autologous serum eyedrops. We evaluated the results of Schirmer test, fluorescein and rose bengal staining scores, tear film breakup time (BUT), and subjective symptom scores before and 2 weeks after treatment.
  
  
  RESULTS
  Mean BUT and fluorescein and rose bengal staining scores, as well as subjective symptom scores, showed significant improvement in the patients assigned to autologous serum eyedrops compared with subjects assigned to preservative-free artificial tears after 2 weeks of treatment.
  
  
  CONCLUSIONS
  Autologous serum eyedrops were found effective in the treatment of severe dry eye disease, as evidenced by improvement of tear stability and ocular surface vital staining scores.
authors.affiliation: Department of Ophthalmology, Social Insurance Chukyo Hospital, Aichi, Japan. kojikoji@ymail.plala.or.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kojima
authors.forename: Reiko
authors.initials: R
authors.lastname: Ishida
authors.forename: Murat
authors.initials: M
authors.lastname: Dogru
authors.forename: Eiki
authors.initials: E
authors.lastname: Goto
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Minako
authors.initials: M
authors.lastname: Kaido
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000368:Aged; D001798:Blood Proteins / Q000008:administration & dosage*; D016022:Case-Control Studies; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D019793:Fluorescein; D005456:Fluorescent Dyes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D011446:Prospective Studies; D012395:Rose Bengal; D044967:Serum; D013666:Tears / Q000737:chemistry
chemical_list: D001798:Blood Proteins; D005456:Fluorescent Dyes; D009883:Ophthalmic Solutions; D012395:Rose Bengal; D019793:Fluorescein