title: Allergic contact dermatitis from isocyanates among sculptors.
abstract: Allergic contact dermatitis from isocyanates is rare. We present the cases of two sculptors who developed a dermatitis from polyurethane sculpting materials. The patients reacted to diphenylmethane diisocyanate and isophorone diisocyanate. One of the patients had positive patch-test reactions to 1,6-hexamethylene diisocyanate and toluene diisocyanate as well. The patients also exhibited a sensitivity to diaminodiphenylmethane, an amine that has been reported in other cases of isocyanate sensitivity.
authors.affiliation: Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19147, USA. Giuseppe.Militell@uphs.upenn.edu
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Militello
authors.forename: Denis
authors.initials: D
authors.lastname: Sasseville
authors.forename: Cherie
authors.initials: C
authors.lastname: Ditre
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Brod
mesh_terms: D000328:Adult; D000485:Allergens / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology*; D004853:Epoxy Resins / Q000009:adverse effects; D005260:Female; D006801:Humans; D017953:Isocyanates / Q000009:adverse effects*; D011140:Polyurethanes / Q000009:adverse effects; D012613:Sculpture; D001559:Benzhydryl Compounds
chemical_list: D000485:Allergens; D004853:Epoxy Resins; D017953:Isocyanates; D011140:Polyurethanes; C015301:isophorone diisocyanate; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds