Opioids and central sensitisation: II. Induction and reversal of hyperalgesia.
Opioids are powerful analgesics when used to treat acute pain and some forms of chronic pain. In addition, opioids can preempt some forms of central sensitization. Here we review evidence that opioids may also induce and perhaps reverse some forms of central sensitization.
Ruscheweyh
Ruth
R
Department of Neurophysiology, Centre for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria.
Sandkühler
Jürgen
J
D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects*; D000818:Animals; D004359:Drug Therapy, Combination; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage*; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced* / Q000517:prevention & control*
D000701:Analgesics, Opioid; D018691:Excitatory Amino Acid Antagonists