title: [Genetic vaccines].
abstract: Vaccination with DNA-vaccines is a new approach in immunization that implies application of genetic constructions coding certain proteins of various pathogens instead of conventional ways of vaccination with inactivated or attenuated microorganisms. The main advantage of this approach consists in possibility to induce immune response in cases when the disease cannot be prevented by routinely used prophylactic vaccines. This advantage is attributed to the ability of DNA-vaccines to focus immune response (cellular, humoral or both) upon one or several certain pathogenic antigens, which is impossible in principle when conventional vaccines are used and does not occur during an infectious process. The efficiency of DNA-vaccines is currently being tested in various pre-clinical and clinical trials. Genetic vaccination has induced protective or therapeutic immune response in a significant number of these trials. However, despite numerous positive results, clinical use of DNA-vaccines has not been recommended yet.
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Logunov
authors.forename: B S
authors.initials: BS
authors.lastname: Naroditskiĭ
authors.forename: A L
authors.initials: AL
authors.lastname: Gintsburg
authors.forename: A A
authors.initials: AA
authors.lastname: Vorob'ev
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000517:prevention & control*; D004333:Drug Administration Routes; D006801:Humans; D007109:Immunity / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D014611:Vaccination / Q000379:methods*; D019444:Vaccines, DNA / Q000008:administration & dosage; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control*
chemical_list: D019444:Vaccines, DNA