title: Wavelet thresholding with bayesian false discovery rate control.
abstract: The false discovery rate (FDR) procedure has become a popular method for handling multiplicity in high-dimensional data. The definition of FDR has a natural Bayesian interpretation; it is the expected proportion of null hypotheses mistakenly rejected given a measure of evidence for their truth. In this article, we propose controlling the positive FDR using a Bayesian approach where the rejection rule is based on the posterior probabilities of the null hypotheses. Correspondence between Bayesian and frequentist measures of evidence in hypothesis testing has been studied in several contexts. Here we extend the comparison to multiple testing with control of the FDR and illustrate the procedure with an application to wavelet thresholding. The problem consists of recovering signal from noisy measurements. This involves extracting wavelet coefficients that result from true signal and can be formulated as a multiple hypotheses-testing problem. We use simulated examples to compare the performance of our approach to the Benjamini and Hochberg (1995, Journal of the Royal Statistical Society, Series B57, 289-300) procedure. We also illustrate the method with nuclear magnetic resonance spectral data from human brain.
authors.affiliation: Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. mtadesse@cceb.upenn.edu
authors.forename: Mahlet G
authors.initials: MG
authors.lastname: Tadesse
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Ibrahim
authors.forename: Marina
authors.initials: M
authors.lastname: Vannucci
authors.forename: Robert
authors.initials: R
authors.lastname: Gentleman
mesh_terms: D001499:Bayes Theorem; D001699:Biometry; D001921:Brain; D003198:Computer Simulation; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D011336:Probability