title: Allergic contact dermatitis from cocamidopropyl betaine, cocamidoamine, 3-(dimethylamino)propylamine, and oleamidopropyl dimethylamine: co-reactions or cross-reactions?
abstract: We present the case of a patient with facial dermatitis caused by sensitization to cocamidopropyl betaine. The patient also had positive patch-test reactions to cocamidoamine, 3-(dimethylamino)propylamine, and oleamidopropyl dimethylamine. The presence of 3-(dimethylamino)propylamine as an impurity in all of these substances can be hypothesized to explain these simultaneous reactions.
authors.affiliation: McGill University Health Centre, Montreal, Canada.
authors.forename: Linda
authors.initials: L
authors.lastname: Moreau
authors.forename: Denis
authors.initials: D
authors.lastname: Sasseville
mesh_terms: D000328:Adult; D000485:Allergens / Q000009:adverse effects; D001622:Betaine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D003358:Cosmetics / Q000009:adverse effects*; D003429:Cross Reactions; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D003959:Diamines / Q000009:adverse effects*; D004357:Drug Synergism; D005260:Female; D006203:Hair Preparations / Q000009:adverse effects*; D006801:Humans; D011437:Propylamines / Q000009:adverse effects*; D013501:Surface-Active Agents / Q000009:adverse effects*
chemical_list: D000485:Allergens; D003358:Cosmetics; D003959:Diamines; D006203:Hair Preparations; D011437:Propylamines; D013501:Surface-Active Agents; C044477:N-(3-(dimethylamino)propyl)oleamide; D001622:Betaine; C077055:cocamidopropyl betaine; C012928:3-dimethylaminopropylamine