title: High frequency stimulation of the subthalamic nucleus is efficacious in Parkin disease.
abstract: High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an efficacious symptomatic treatment for Parkinson's disease. We have analysed the genetic status of a series of consecutive parkinsonian patients implanted for STN HFS and compared the outcome of five carrying mutations in the parkin gene with that of the non-parkin group. All patients obtained sustained control of PD symptoms and achieved functional improvement; in the parkin group the UPDRS motor score improved by 56.4%, the levodopa equivalent daily dosage was reduced by 75.5%. Postoperative medications were reduced more in parkin than in non-parkin patients. We confirm that the current inclusion criteria for STN HFS do not exclude patients carrying mutations in the parkin gene; their clinical outcome is comparable to that of the non-parkin group.
authors.affiliation: Istituto Nazionale Neurologico Carlo Besta, Via G. Celoria, 11, 20133 Milano, Italy.
authors.forename: Luigi M A
authors.initials: LM
authors.lastname: Romito
authors.forename: Maria F
authors.initials: MF
authors.lastname: Contarino
authors.forename: Daniele
authors.initials: D
authors.lastname: Ghezzi
authors.forename: Angelo
authors.initials: A
authors.lastname: Franzini
authors.forename: Barbara
authors.initials: B
authors.lastname: Garavaglia
authors.forename: Alberto
authors.initials: A
authors.lastname: Albanese
mesh_terms: D000328:Adult; D046690:Deep Brain Stimulation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics* / Q000628:therapy; D018709:Statistics, Nonparametric; D020531:Subthalamic Nucleus / Q000528:radiation effects*; D016896:Treatment Outcome; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: D044767:Ubiquitin-Protein Ligases; C111567:parkin protein
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