Endometrial adenosquamous carcinoma with osteoclast-like giant cells: immunohistochemistry and histogenesis.
Primary extraskeletal epithelial neoplasms containing osteoclast-like giant cells (OGCs) are rare. We herein describe a case of adenosquamous carcinoma that developed in the endometrium together with non-neoplastic OGCs. The patient was a 72-year-old woman who underwent radical hysterectomy with salpingo-oophorectomy and lymph node dissection after being diagnosed with uterine cancer. Histologically, the tumor was found to be an adenosquamous carcinoma containing a large number of OGCs and mononuclear cells (MNCs) that had infiltrated into the stroma. Immunohistochemically, the OGCs and MNCs stained strongly positive for KP-1 and alpha-1-antichymotrypsin, and negative for the epithelial markers epithelial membrane antigen (EMA) and cytokeratins. These findings suggest that the OGCs and MNCs in this patient's tumor originated from monocytes/histiocytes, and most likely developed as part of the stromal reaction to the neoplasm.
Imura
Johji
J
Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Tochigi, Japan. imura@dokkyomed.ac.jp
Tomita
Shigeki
S
Ono
Yuko
Y
Inaba
Fujiyuki
F
Yamazaki
Tatsuo
T
Fukasawa
Ichio
I
Inaba
Noriyuki
N
Fujimori
Takahiro
T
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D019070:Cell Lineage; D016889:Endometrial Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015726:Giant Cells / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology; D010010:Osteoclasts / Q000378:metabolism / Q000473:pathology*