title: A concordance study of three electrophysiological measures in schizophrenia.
abstract: OBJECTIVE
  The authors evaluated concordance rates among three electrophysiological measures in patients with schizophrenia, nonschizophrenic first-degree relatives of schizophrenia patients, and healthy comparison subjects. The purpose of the study was to provide data for defining a common endophenotype for genetic studies of schizophrenia and for improving the criteria for diagnosis.
  
  
  METHODS
  P50 event-related potential inhibition, antisaccade, and smooth pursuit eye tracking paradigms were measured. Data for all three paradigms were available for 81 patients with schizophrenia, 25 parents of patients with schizophrenia, and 60 healthy comparison subjects.
  
  
  RESULTS
  The schizophrenia patients and the patients' parents showed a high rate of inhibitory deficits measured by the P50 inhibition and antisaccade paradigms. Both groups had a high prevalence of eye tracking dysfunction. Smooth pursuit gain and the error rate in the antisaccade paradigm were significantly correlated in the schizophrenia patients and the parents, whereas P50 inhibition showed no correlation with smooth pursuit gain or antisaccade paradigm measurements.
  
  
  CONCLUSIONS
  Despite superficial similarities, two paradigms designed to measure central inhibition processes (antisaccade and P50 inhibition) do not appear to reflect the same neurobiological substrates. In contrast, the convergence in performance data for the antisaccade and eye tracking paradigms suggests that the neural circuitry underlying these tasks may overlap. P50 inhibition and antisaccade errors were the optimal paradigms for discrimination between comparison subjects, patients with schizophrenia, and the parents of patients with schizophrenia.
authors.affiliation: Department of Psychiatry, Rouen University Hospital Charles Nicolle, 1 rue de Germont 76031 Rouen Cedex, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Louchart-de la Chapelle
authors.forename: Irène
authors.initials: I
authors.lastname: Nkam
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Houy
authors.forename: Angélique
authors.initials: A
authors.lastname: Belmont
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Ménard
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Roussignol
authors.forename: Ophélie
authors.initials: O
authors.lastname: Siwek
authors.forename: Mustapha
authors.initials: M
authors.lastname: Mezerai
authors.forename: Marion
authors.initials: M
authors.lastname: Guillermou
authors.forename: Gaël
authors.initials: G
authors.lastname: Fouldrin
authors.forename: Daniel
authors.initials: D
authors.lastname: Levillain
authors.forename: Sonia
authors.initials: S
authors.lastname: Dollfus
authors.forename: Dominique
authors.initials: D
authors.lastname: Campion
authors.forename: Florence
authors.initials: F
authors.lastname: Thibaut
mesh_terms: D000328:Adult; D004569:Electroencephalography / Q000706:statistics & numerical data; D004594:Electrophysiology / Q000706:statistics & numerical data; D005072:Evoked Potentials, Auditory / Q000235:genetics / Q000502:physiology*; D005133:Eye Movements / Q000235:genetics / Q000502:physiology*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015835:Ocular Motility Disorders / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D010290:Parents; D010641:Phenotype; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D011698:Pursuit, Smooth / Q000235:genetics / Q000502:physiology; D012372:ROC Curve; D011930:Reaction Time / Q000502:physiology; D013216:Reflex, Startle / Q000235:genetics / Q000502:physiology*; D012438:Saccades / Q000235:genetics / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*
chemical_list: D005819:Genetic Markers