title: Apolipoprotein E and category fluency: evidence for reduced semantic access in healthy normal controls at risk for developing Alzheimer's disease.
abstract: Two groups of non-demented individuals, who differed on genetic risk for Alzheimer's disease (AD) based on their apolipoprotein E (APOE) genotype, were tested on a category fluency task. Twenty varepsilon4 carriers and twenty varepsilon4 non-carriers were tape recorded while saying animal names for ten minutes. Five measures were examined: total names generated; total clusters; mean cluster size; mean within-cluster retrieval time; and mean between-cluster retrieval time. Groups were matched on age and education and scored as normal on a battery of psychometric tests. The varepsilon4 carriers generated significantly fewer names and clusters, and took significantly longer to access clusters, when compared to the varepsilon4 non-carriers. No group differences were found for cluster size or within-cluster retrieval times. We previously reported [Rosen, V. M., Bergeson, J. L., Putnam, K., Harwell, A., Sunderland, T. (2002). Working memory and apolipoprotein E: What's the connection? Neuropsychologia 40, 2226-2233] that the varepsilon4 carriers in the present study scored significantly lower than the varepsilon4 non-carriers on a measure of working memory/attentional capacity [Operation Span Task, see Turner, M. L., Engle, R. W. (1989). Is working memory capacity task dependent? Journal of Memory and Language 28, 127-154]. In the present study, a significant negative relationship found between span performance and between-cluster retrieval times suggested that reduced attentional capacity may have negatively impacted semantic access for the varepsilon4 carriers. Finally, we found significant relationships between a Trail Making Test [Reitan, R. M. (1992). Trail Making Test, manual for administration and scoring. Tucson, AZ: Reitan Neuropsychology Laboratory] "switch" measure (Form B-Form A) and three of the five fluency measures. The findings suggested that the varepsilon4 carrier's reduced attentional capacity may have interfered with their covertly shifting attention among subcategories in the fluency task, resulting in fewer names and clusters generated and longer times to access clusters.
authors.affiliation: Department of Psychology, Syracuse University, 430 Huntington Hall, Syracuse, NY 13244, USA. vrosen@syr.edu
authors.forename: Virginia M
authors.initials: VM
authors.lastname: Rosen
authors.forename: Trey
authors.initials: T
authors.lastname: Sunderland
authors.forename: James
authors.initials: J
authors.lastname: Levy
authors.forename: Angela
authors.initials: A
authors.lastname: Harwell
authors.forename: Lori
authors.initials: L
authors.lastname: McGee
authors.forename: Christopher
authors.initials: C
authors.lastname: Hammond
authors.forename: Deepa
authors.initials: D
authors.lastname: Bhupali
authors.forename: Karen
authors.initials: K
authors.lastname: Putnam
authors.forename: Judy
authors.initials: J
authors.lastname: Bergeson
authors.forename: Charlene
authors.initials: C
authors.lastname: Lefkowitz
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology*; D001057:Apolipoproteins E / Q000235:genetics*; D001288:Attention; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007802:Language; D008297:Male; D008568:Memory; D008606:Mental Processes; D008875:Middle Aged; D012307:Risk Factors; D012660:Semantics; D013647:Task Performance and Analysis
chemical_list: D001057:Apolipoproteins E