Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer.
To identify genes that generally increase the risk of cancer, we performed a systematic search throughout the genome in 188 families primarily ascertained for prostate cancer but which also included individuals with other cancers. We observed significant evidence for linkage between susceptibility to all cancers and markers at 3p24, with a peak HLOD of 3.08 (P=0.0002). Compared to families with less than three other cancers and prostate cancer only, evidence for linkage at this region was stronger among families with at least three other cancers. This is the first reported example of a genome-wide search for general cancer susceptibility genes among hereditary prostate cancer families.
Chang
Bao-Li
BL
Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Gillanders
Elizabeth M
EM
Isaacs
Sarah D
SD
Wiley
Kathy E
KE
Adams
Tamara
T
Turner
Aubrey R
AR
Zheng
S Lilly
SL
Meyers
Deborah A
DA
Carpten
John D
JD
Walsh
Patrick C
PC
Trent
Jeffrey M
JM
Xu
Jianfeng
J
Isaacs
William B
WB
D002893:Chromosomes, Human, Pair 3; D005190:Family; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010375:Pedigree; D011471:Prostatic Neoplasms / Q000235:genetics*