title: Angiotensin I converting enzyme polymorphism effects in patients with normal pressure hydrocephalus syndrome before and after surgery.
abstract: Previous reports have suggested an association between the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE), cardiovascular disease, and cognitive performance. Normal pressure hydrocephalus (NPH) is considered to be an example of reversible dementia although the clinical improvement after shunting varies from subject to subject. An association has been suggested between vascular risk factors and the development of NPH. The ACE plays a major role in vascular pathology and physiology. In the present study we investigated the distribution of an ACE gene insertion/deletion polymorphism in 112 patients diagnosed with NPH and in 124 controls. We also evaluated the role of this genetic polymorphism in cognitive functioning before and following surgery in a subgroup of 72 patients. No differences in genetic or allele distributions were found between patients and healthy subjects, but among patients, carriers of D/D or D/I genotypes obtained less cognitive benefit following shunt surgery, especially on measures of memory and frontal function. Our data support previous findings in other conditions indicating that possession of at least one D allele is associated with poorer cognitive performance.
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain. matarinmegelonia@mih.gov
authors.forename: Maria
authors.initials: M
authors.lastname: del Mar Matarín
authors.forename: Maria Antonia
authors.initials: MA
authors.lastname: Poca
authors.forename: David
authors.initials: D
authors.lastname: Bartrés-Faz
authors.forename: Maria
authors.initials: M
authors.lastname: Mataró
authors.forename: Imma C
authors.initials: IC
authors.lastname: Clemente
authors.forename: Cristina
authors.initials: C
authors.lastname: Solé-Padullés
authors.forename: Emili
authors.initials: E
authors.lastname: González-Pérez
authors.forename: Pedro
authors.initials: P
authors.lastname: Moral
authors.forename: Maite
authors.initials: M
authors.lastname: Barrios
authors.forename: Carme
authors.initials: C
authors.lastname: Junqué
authors.forename: Juan
authors.initials: J
authors.lastname: Sahuquillo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D002557:Cerebrospinal Fluid Shunts / Q000379:methods*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006849:Hydrocephalus / Q000235:genetics* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011597:Psychomotor Performance / Q000502:physiology
chemical_list: D007703:Peptidyl-Dipeptidase A
references.citation: Lancet. 2000 Jan 22;355(9200):253-9
references.pmid: 10675071
references.citation: Lancet. 1991 May 11;337(8750):1158-9
references.pmid: 1674030
references.citation: Neurosci Lett. 1996 Oct 18;217(2-3):203-5
references.pmid: 8916108
references.citation: N Engl J Med. 2000 Jan 20;342(3):145-53
references.pmid: 10639539
references.citation: Neurosurgery. 1997 Mar;40(3):491-5; discussion 495-6
references.pmid: 9055287
references.citation: Clin Genet. 1997 May;51(5):354-6
references.pmid: 9212187
references.citation: N Engl J Med. 1965 Jul 15;273:117-26
references.pmid: 14303656
references.citation: Nat Genet. 1999 Jan;21(1):71-2
references.pmid: 9916793
references.citation: N Engl J Med. 1986 Jun 26;314(26):1657-64
references.pmid: 3520318
references.citation: J Neurol Sci. 1965 Jul-Aug;2(4):307-27
references.pmid: 5889177
references.citation: J Neurosurg. 1999 Feb;90(2):221-6
references.pmid: 9950492
references.citation: Neurosci Lett. 2000 Sep 1;290(3):177-80
references.pmid: 10963892
references.citation: Hypertension. 1999 Sep;34(3):496-502
references.pmid: 10489400
references.citation: J Neurochem. 1982 May;38(5):1490-2
references.pmid: 6278093
references.citation: Acta Neurochir (Wien). 1991;112(1-2):50-61
references.pmid: 1763684
references.citation: J Neurol Sci. 2002 Nov 15;203-204:147-51
references.pmid: 12417374
references.citation: J Cardiovasc Pharmacol. 1992;19 Suppl 6:S63-71
references.pmid: 1382167
references.citation: Ann Neurol. 2003 Mar;53(3):337-46
references.pmid: 12601701
references.citation: Behav Brain Res. 2002 Feb 1;129(1-2):31-9
references.pmid: 11809492
references.citation: Acta Psychiatr Scand. 1982 Feb;65(2):93-100
references.pmid: 7187181
references.citation: Neurobiol Aging. 2000 Jan-Feb;21(1):75-80
references.pmid: 10794851
references.citation: Stroke. 1996 Jan;27(1):24-9
references.pmid: 8553398
references.citation: J Psychiatr Res. 1975 Nov;12(3):189-98
references.pmid: 1202204
references.citation: Nature. 1992 Oct 15;359(6396):641-4
references.pmid: 1328889
references.citation: J Neurol Neurosurg Psychiatry. 1999 Dec;67(6):723-32
references.pmid: 10567486
references.citation: J Cardiovasc Pharmacol. 1990 Aug;16(2):234-8
references.pmid: 1697379
references.citation: Mol Pathol. 2002 Feb;55(1):29-33
references.pmid: 11836444
references.citation: Am J Hum Genet. 1992 Jul;51(1):197-205
references.pmid: 1319114
references.citation: Neurologia. 2001 Oct;16(8):353-69
references.pmid: 11738013
references.citation: Acta Neurochir Suppl. 2002;81:3-5
references.pmid: 12168331
references.citation: Acta Neurol Scand. 2001 Nov;104(5):281-7
references.pmid: 11696022
references.citation: Arch Clin Neuropsychol. 1988;3(4):323-30
references.pmid: 14591422
references.citation: Ann N Y Acad Sci. 2000 Apr;903:437-41
references.pmid: 10818534
references.citation: Kidney Int. 2000 Feb;57(2):561-9
references.pmid: 10652033
references.citation: Lancet. 1994 Apr 2;343(8901):851
references.pmid: 7908092
references.citation: Neurology. 1987 May;37(5):868-71
references.pmid: 3574694
references.citation: Pharmacol Biochem Behav. 1993 Jun;45(2):455-64
references.pmid: 8327552
references.citation: J Clin Invest. 1990 Oct;86(4):1343-6
references.pmid: 1976655
references.citation: Hypertension. 2003 Oct;42(4):542-7
references.pmid: 12963679