title: TT virus infection among Egyptian patients with hepatocellular carcinoma.
abstract: Hepatitis B and C viruses (HBV and HCV) have been associated with hepatocellular carcinoma (HCC). Recently, a novel DNA virus was isolated from a patient with posttransfusion hepatitis of unknown etiology and designated TT virus (TTV). To examine whether this virus is associated with HCC, we investigated sera from 82 Egyptian patients with histopathologically-diagnosed HCC. All subjects underwent serological investigations for detection of hepatitis B surface antigen (HbsAg), hepatitis B core antibody (HbcAb) and anti-HCV. Detection of TTV-DNA was performed by semi-nested polymerase chain reaction (PCR) using TTV-specific primers. TTV-DNA was detected in 28% of the patients. Age, gender, risk factors and biochemical liver functions did not significantly differ between TTV-DNA positive and negative patients. TTV was detected in 27.1% of patients with HCV-HCC, 25% of HBV-HCC, 66.7% of dual HCV and HBV infection and 40% of those with non-B, non-C-HCC (NBNC-HCC). It is concluded that, in this the cohort of Egyptian patients with HCC, TTV infection is common and is not associated with HCV, HBV, NBNC-HCC, history of schistosomiasis or blood transfusion.
authors.affiliation: Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt.
authors.forename: Howayda
authors.initials: H
authors.lastname: Hassoba
authors.forename: Moushira
authors.initials: M
authors.lastname: Mahmoud
authors.forename: Hanaa
authors.initials: H
authors.lastname: Fahmy
authors.forename: Ola
authors.initials: O
authors.lastname: Leheta
authors.forename: Amal
authors.initials: A
authors.lastname: Sayed
authors.forename: Amal
authors.initials: A
authors.lastname: Fathy
authors.forename: Abdelhamid
authors.initials: A
authors.lastname: Serwah
authors.forename: Amr
authors.initials: A
authors.lastname: Abbas
authors.forename: Zohair
authors.initials: Z
authors.lastname: Nooman
authors.forename: Fawzy
authors.initials: F
authors.lastname: Attia
authors.forename: Yuri
authors.initials: Y
authors.lastname: Khudyakov
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000821:virology; D018173:Circoviridae Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000821:virology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D022783:Torque teno virus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity
chemical_list: D004279:DNA, Viral