title: [Biochemical evaluation of the results of lipid regulating treatment in France].
abstract: The objective of the SPOT study (Study of Practice versus Objectives of Treatment) was the biochemical evaluation of the results of long term lipid regulating treatment in France, compared to the objectives defined by AFSSAPS (French regulatory agency for the safety of medical products) in 2000. A random sample of doctors was recruited in 21 French regions by the Regional Health Observation service. To be included in the SPOT study, the patients had to be on lipid regulating medication for at least six months and consent to biochemical evaluation following a consultation. A sample of 641 doctors examined 2,479 patients treated for 7 years on average. These middle aged patients (aged 63 +/- 11 years) were mostly taking statins (72%). They had an average total cholesterol level of 5.41 +/- 1.01 mmol/L (2.10 +/- 0.39 g/L). and LDL of 3.25 +/- 0.93 mmol/L (1.26 +/- 0.36 g/L), reflecting previous results and confirming the stability of their treatment. In primary prevention and in low risk subjects (with less than 2 associated risk factors), the AFSSAPS objectives were achieved in 95% of cases. In secondary prevention or in very high risk subjects (at least 3 associated risk factors 0), 35% of patients had LDL cholesterol greater than 3.4 mmol/L (1.30 g/L). The SPOT study, performed on subjects who had in theory been stabilised with lipid regulating medication, gave two conclusions: cardiovascular prevention with lipid regulating medication is improving in France, and the subjects at greatest risk attain the recommended objectives less often despite the expected benefit of treatment being higher.
authors.affiliation: Unité de prévention de l'athérosclérose, service de cardiologie B, CHU Rangueil, Toulouse. jean.ferrieres@cict.fr
authors.forename: J
authors.initials: J
authors.lastname: Ferrières
authors.forename: J M
authors.initials: JM
authors.lastname: Lablanche
authors.forename: D
authors.initials: D
authors.lastname: Pouchain
authors.forename: X
authors.initials: X
authors.lastname: Girerd
authors.forename: M
authors.initials: M
authors.lastname: Krempf
authors.forename: G
authors.initials: G
authors.lastname: Nguyen
authors.forename: P Y
authors.initials: PY
authors.lastname: Glanddier
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D005260:Female; D005602:France; D019538:Health Care Surveys; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000960:Hypolipidemic Agents