title: Synthesis of isonicotinic acid N'-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents.
abstract: A new series of antituberculosis agents 6-9 was designed, synthesized and evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv and clinical isolates in an agar dilution method. Compound 9h showed comparable in vitro activity (MIC) to isoniazid against M. tuberculosis H37Rv and clinical isolates (sensitive strains) and superior activity against resistant strains of M. tuberculosis.
authors.affiliation: Medicinal Chemistry Division, New Chemical Entity Research, Lupin Research Park, 46/47A, Village Nande, Taluka Mulshi, Pune 411 042, Maharashtra, India. neelimasinha@lupinpharma.com
authors.forename: Neelima
authors.initials: N
authors.lastname: Sinha
authors.forename: Sanjay
authors.initials: S
authors.lastname: Jain
authors.forename: Ajay
authors.initials: A
authors.lastname: Tilekar
authors.forename: Ram Shankar
authors.initials: RS
authors.lastname: Upadhayaya
authors.forename: Nawal
authors.initials: N
authors.lastname: Kishore
authors.forename: Gour Hari
authors.initials: GH
authors.lastname: Jana
authors.forename: Sudershan K
authors.initials: SK
authors.lastname: Arora
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007539:Isonicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D007539:Isonicotinic Acids