[Progress in research on triptolide].
To further understand triptolide, this paper has introduced the pharmacology, pharmacokinetics, toxicity, the clinic application and semi-synthesis of triptolide on basis of importance and significant contents of reference which have been consulted in the past twenty years. Presently triptolide and Tripterygium wilfordii have been a hot spot of modernization of Chinese traditional medicine. It is very important to develop a new dosage form of high effect and low toxicity by making use of advanced technology according to its characteristics.
Liu
Ming-xing
MX
The Research Institute of Pharmaceutics, Huazhong University of Science and Technology, Wuhan 430074, China.
Dong
Jing
J
Yang
Ya-jiang
YJ
Yang
Xiang-liang
XL
Xu
Hui-bi
HB
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D000988:Antispermatogenic Agents / Q000494:pharmacology; D004224:Diterpenes / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D004852:Epoxy Compounds; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D010616:Phenanthrenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D029757:Tripterygium / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018906:Antineoplastic Agents, Alkylating; D000988:Antispermatogenic Agents; D004224:Diterpenes; D004852:Epoxy Compounds; D007166:Immunosuppressive Agents; D010616:Phenanthrenes; C001899:triptolide; C035061:triptophenolide