Amide-ligand hydrogen bonding in reverse micelles.
One approach to modeling the second coordination shell of metalloproteins is to pair amide-containing counterions with metal complexes to form hydrogen bonds in the solid state. In a more general approach, we have designed a surfactant counterion that can sustain hydrogen bonding interactions with metal complexes in solution. The surfactant is cationic and incorporates an amide as part of its headgroup to form hydrogen. The surfactant forms hydrogen bonding reverse micelles that accommodate anionic metal complexes in their polar core. In reverse micelles containing an iron(III) hexacyanide complex, spectroscopic evidence suggests that the anion is confined to the polar core region in solution. Single-crystal X-ray diffraction data on the surfactant ferricyanide system reveals a layered structure with interdigitated alkyl chains and an extensive network of hydrogen bonds that link amide groups to the cyanide ligands and to neighboring headgroups.
Walters
Marc A
MA
Department of Chemistry, New York University, New York, New York 10003, USA. marc.walters@nyu.edu
Tadross
Pamela M
PM
Rheingold
Arnold L
AL
Zakharov
Lev N
LN
Mudzudzu
Danai
D
Texter
John
J
D000577:Amides / Q000737:chemistry*; D005292:Ferricyanides / Q000737:chemistry; D006860:Hydrogen Bonding; D008024:Ligands; D008823:Micelles; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D013501:Surface-Active Agents
D000577:Amides; D005292:Ferricyanides; D008024:Ligands; D008823:Micelles; D013501:Surface-Active Agents