title: Bonelike/PLGA hybrid materials for bone regeneration: preparation route and physicochemical characterisation.
abstract: Bonelike/PLGA hybrid materials have been developed using gamma-MPS as silane-coupling agent between the inorganic and organic phases for controlled drug delivery applications. Silanization showed to be more effective when cyclohexane was used as a non-polar solvent (nP method) due to a chemical interaction between Bonelike, and the silane film, while by using a 95/5 (V/V) methanol/water as a polar solvent (P method), a much thinner film was achieved. Functional groups of PLGA, such as the carbonyl group (C=O), were identified using Raman and FTIR-ATR analysis and therefore these groups may be used to link therapeutic molecules. These novel hybrid materials prepared by combining silanization and post-hybridisation processes are expected to find use in medical applications of bone regeneration and as drug delivery carrier for therapeutic molecules.
authors.affiliation: INEB-Instituto de Engenharia Biomédica, Laboratório de Biomateriais, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal.
authors.forename: J M
authors.initials: JM
authors.lastname: Oliveira
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
authors.forename: M A
authors.initials: MA
authors.lastname: Lopes
authors.forename: C
authors.initials: C
authors.lastname: Ohtsuki
authors.forename: J D
authors.initials: JD
authors.lastname: Santos
mesh_terms: D001861:Bone Regeneration; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D017886:Durapatite / Q000737:chemistry; D019344:Lactic Acid / Q000138:chemical synthesis* / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011100:Polyglycolic Acid / Q000138:chemical synthesis* / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013059:Spectrum Analysis, Raman; D014965:X-Rays
chemical_list: D011108:Polymers; D012821:Silanes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D017886:Durapatite
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