Experimental tooth movement upregulates preproenkephalin mRNA in the rat trigeminal nucleus caudalis and oralis.
Levels of preproenkephalin mRNA expression in trigeminal subnucleus complex by noxious tooth movement stimuli were examined using in situ hybridization. At 24 h, preproenkephalin mRNA expression was significantly upregulated in the ipsilateral trigeminal subnucleus caudalis (P<0.05), and in the subnucleus oralis (P<0.05). These findings suggested that enkephalinergic inhibitory systems could be activated during tooth movement, and that subnucleus oralis may be involved in modulation of the nociception, as well as the subnucleus caudalis.
Balam
Tarek A
TA
Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-Cho, Okayama 700-8525, Japan.
Yamashiro
Takashi
T
Zheng
Li
L
Murshid Ahmed
Sakhr
S
Fujiyoshi
Yoshiaki
Y
Takano-Yamamoto
Teruko
T
D000344:Afferent Pathways / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D004745:Enkephalins / Q000235:genetics* / Q000378:metabolism; D007839:Functional Laterality / Q000502:physiology; D008297:Male; D009433:Neural Inhibition / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D009967:Orthodontic Appliances / Q000009:adverse effects; D010146:Pain / Q000378:metabolism* / Q000503:physiopathology; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014070:Tooth / Q000294:innervation* / Q000502:physiology; D014275:Trigeminal Caudal Nucleus / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology
D004745:Enkephalins; D011498:Protein Precursors; D012333:RNA, Messenger; C033660:preproenkephalin