Modulation of the ARF-p53 pathway by the small DNA tumor viruses.
The small DNA tumor viruses encode proteins that subvert many of the pivotal growth regulatory pathways within the cell to facilitate their own replication. The cell responds to viral infection/proteins by activating the p53 tumor suppressor pathway. Activation of p53 could impair a productive viral infection at many levels, including the inhibition of viral DNA replication and/or the premature death of infected cells. Therefore, DNA viruses encode proteins that inactivate the p53 tumor suppressor pathway. Understanding how DNA viral proteins activate/inactivate the p53 pathway has provided invaluable insights into tumorigenesis. Recent studies with polyoma virus have identified a viral protein (PyST) that inhibits ARF-mediated activation of p53, and revealed a novel role for PP2A in the regulation of the ARF-p53 tumor suppressor pathway.
O'Shea
Clodagh C
CC
UCSF Cancer Research Institute, San Francisco, California 94115, USA.
Fried
Mike
M
D020823:ADP-Ribosylation Factor 1 / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000378:metabolism; D002453:Cell Cycle; D004247:DNA / Q000737:chemistry*; D004279:DNA, Viral / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D016147:Genes, Tumor Suppressor; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D009687:Nuclear Proteins; D009858:Oncogenic Viruses / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry* / Q000378:metabolism
D000952:Antigens, Polyomavirus Transforming; D004279:DNA, Viral; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53; D004247:DNA; D020823:ADP-Ribosylation Factor 1