Long-chain acyl-CoA hydrolase in the brain.
Long-chain acyl-CoA hydrolases are a group of enzymes that cleave acyl-CoAs into fatty acids and coenzyme A (CoA-SH). Because acyl-CoAs participate in numerous reactions encompassing lipid synthesis, energy metabolism and regulation, modulating intracellular levels of acyl-CoAs would affect cellular functions. Therefore, acyl-CoA synthetases have been intensively studied. In contrast, acyl-CoA hydrolases have been less investigated, especially in the brain despite the fact that its long-chain acyl-CoA hydrolyzing activity is much higher than that in any other organ in the body. However, recent studies have dissected the multiplicity of this class of enzymes on a genomic basis, and have allowed us to discuss their function. Here, we describe a cytosolic long-chain acyl-CoA hydrolase (referred to as BACH) that is constitutively expressed in the brain, comparing it with other acyl-CoA hydrolases found in peripheral organs that have a role in fatty acid oxidation.
Yamada
J
J
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Tokyo, Japan. junymd@ps.toyaku.ac.jp
D000214:Acyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D003066:Coenzyme A Ligases / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008050:Lipid A / Q000096:biosynthesis*; D009928:Organ Specificity / Q000502:physiology
D000214:Acyl Coenzyme A; D007527:Isoenzymes; D008050:Lipid A; D003066:Coenzyme A Ligases