title: Synthesis and DNA topoisomerase-II inhibitory activity of unnatural nucleosides.
abstract: The synthesis and biological activities of a number of unnatural nucleosides (23-43) is described. Nucleosides have been synthesized by SnCl4-catalyzed condensation of amino sugar acetates and silylated modified pyrimidines. Few of the 2'-O-acetyl derivatives of the nucleosides were hydrolyzed to the respective hydroxy derivatives by treatment with methanol saturated with ammonia. The compounds were screened against Filarial DNA-topoisomerase-II but only one of the compounds (29) inhibited this enzyme at 40 microg/mL of reaction mixture.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, India.
authors.forename: Ram Chandra
authors.initials: RC
authors.lastname: Mishra
authors.forename: Namrata
authors.initials: N
authors.lastname: Dwivedi
authors.forename: Pati Tripathi
authors.initials: PT
authors.lastname: Rama
authors.forename: Iti
authors.initials: I
authors.lastname: Bansal
authors.forename: Jitendra Kumar
authors.initials: JK
authors.lastname: Saxena
mesh_terms: D000085:Acetates / Q000737:chemistry; D000641:Ammonia / Q000737:chemistry; D002384:Catalysis; D006868:Hydrolysis; D000432:Methanol / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D011743:Pyrimidines / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry; D059005:Topoisomerase II Inhibitors
chemical_list: D000085:Acetates; D009705:Nucleosides; D011743:Pyrimidines; D017971:Tin Compounds; D059005:Topoisomerase II Inhibitors; C041694:stannic chloride; D000641:Ammonia; D000432:Methanol