The lambda5-VpreB1 locus--a model system for studying gene regulation during early B cell development.
The lambda5 and VpreB genes encode the components of the surrogate light-chain, which forms part of the pre-B cell receptor. In mouse, the lambda5 and VpreB1 genes of mouse are closely linked and coordinately regulated by a locus control region (LCR). Activation of the genes in pro-B cells depends on the combined effects of early B cell factor (EBF) and the E2A factors E12 and E47. Silencing of lambda5 expression in mature B cells occurs through the action of Ikaros on the gene promoter where it may compete for binding of EBF and initiate the formation of a silent chromatin structure.
Sabbattini
Pierangela
P
Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 ONN, UK. pierangela.sabbattini@csc.mrc.ac.uk
Dillon
Niall
N
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D042002:Chromatin Assembly and Disassembly; D018507:Gene Expression Regulation, Developmental; D020868:Gene Silencing; D007147:Immunoglobulin Light Chains; D054444:Immunoglobulin Light Chains, Surrogate; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000502:physiology; D051379:Mice; D014157:Transcription Factors / Q000378:metabolism*
D007147:Immunoglobulin Light Chains; D054444:Immunoglobulin Light Chains, Surrogate; D008562:Membrane Glycoproteins; D014157:Transcription Factors