title: Immunobiological [correction of Immunobioloical] activity of a new benzyl benzoate from the aerial parts of Solidago virga-aurea var. gigantea.
abstract: The chromatographic separation of the hexane soluble fraction of the methanol extract of the aerial parts of Solidago virga-aurea var. gigantea M(IQ*) (Compositae) led to the isolation of a new benzylbenzoate (1) together with four known benzylbenzoates (2-5). Their structures were determined as 2-methoxybenzyl-2-hydroxybenzoate (1), benzyl-2-hydroxy-6-methoxybenzoate (2), 2-methoxybenzyl-2,6-dimethoxybenzoate (3), 2-methoxybenzyl-2-methoxy-6-hydroxybenzoate (4), and benzyl-2,6-dimethoxybenzoate (5). Their structures were established by spectroscopic methods. Biological effects of compounds, 1 and 2, were investigated in vitro using mouse peritoneal macrophages. The benzylbenzoates (1 and 2) could serve as immunotherapeutic agents by stimulating macrophage functions, with potential use in the treatment of infectious diseases.
authors.affiliation: Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon, Kyunggi-Do 440-746, Korea.
authors.forename: Sang Zin
authors.initials: SZ
authors.lastname: Choi
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Seong Yun
authors.initials: SY
authors.lastname: Bae
authors.forename: Suhk neung
authors.initials: Sn
authors.lastname: Pyo
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001565:Benzoates / Q000276:immunology* / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D035261:Plant Components, Aerial / Q000276:immunology*; D010936:Plant Extracts / Q000276:immunology / Q000302:isolation & purification / Q000494:pharmacology; D036624:Solidago
chemical_list: D000276:Adjuvants, Immunologic; D001565:Benzoates; D010936:Plant Extracts; C006723:benzyl benzoate