title: Marine actinomycete diversity and natural product discovery.
abstract: Microbial natural products remain an important resource for drug discovery yet the microorganisms inhabiting the world's oceans have largely been overlooked in this regard. The recent discovery of novel secondary metabolites from taxonomically unique populations of marine actinomycetes suggests that these bacteria add an important new dimension to microbial natural product research. Continued efforts to characterize marine actinomycete diversity and how adaptations to the marine environment affect secondary metabolite production will create a better understanding of the potential utility of these bacteria as a source of useful products for biotechnology.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0204, USA. pjensen@ucsd.edu
authors.forename: Paul R
authors.initials: PR
authors.lastname: Jensen
authors.forename: Tracy J
authors.initials: TJ
authors.lastname: Mincer
authors.forename: Philip G
authors.initials: PG
authors.lastname: Williams
authors.forename: William
authors.initials: W
authors.lastname: Fenical
mesh_terms: D039903:Actinobacteria / Q000145:classification* / Q000302:isolation & purification / Q000378:metabolism*; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000737:chemistry; D044822:Biodiversity; D001685:Biological Factors / Q000032:analysis* / Q000737:chemistry*; D019015:Geologic Sediments / Q000382:microbiology*; D007783:Lactones / Q000032:analysis / Q000737:chemistry; D011758:Pyrroles; D012623:Seawater
chemical_list: D000903:Antibiotics, Antineoplastic; D001685:Biological Factors; D007783:Lactones; D011758:Pyrroles; C475865:marizomib