Nasopharyngeal carcinoma-susceptibility locus is localized to a 132 kb segment containing HLA-A using high-resolution microsatellite mapping.
Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA-A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA-A locus in Taiwanese NPC patients. However, the pathogenic genes causing NPC susceptibility remain unknown. Here, 8 polymorphic microsatellite markers distributed over a 1 megabase region surrounding the HLA-A locus were subjected to genetic analysis for the NPC-susceptibility locus. Statistical studies of associated alleles detected on each microsatellite locus showed that the NPC- susceptibility genes are most likely located between the D6S510 and D6S211 markers within a 132 kb segment containing the HLA-A locus. These results undoubtedly would facilitate the further positional cloning of the NPC-susceptibility locus, which has been elusive for the past 30 years.
Lu
Cheng-Chan
CC
Department of Pathology, National Cheng Kung University, Tainan, Taiwan. cclu@mail.ncku.edu.tw
Chen
Jung-Chin
JC
Tsai
Sen-Tien
ST
Jin
Ying-Tai
YT
Tsai
Jui-Chen
JC
Chan
Shih-Huang
SH
Su
Ih-Jen
IJ
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000235:genetics*; D013624:Taiwan
D015234:HLA-A Antigens