Antitumor metallothiosemicarbazonates: structure and antitumor activity of palladium complex of phenanthrenequinone thiosemicarbazone.
The crystal structure of the potential antitumor metal compound, viz. chloro, mono(phenanthrenequinone thiosemicarbazonato) palladium(II) dimethyl formamide solvate, is reported. The central palladium(II) atom is in a square planar environment provided by the tridentate, monoanionic thiosemicarbazone ligand and the ancillary chloride ion. The compound exhibited remarkable activity against drug-sensitive and drug-resistant breast cancer cell lines and was relatively nontoxic toward the normal mammary epithelial cells. The drug-induced killing effect against breast cancer cell lines was predominantly mediated via apoptosis, a physiologic form of cell death.
Padhye
Subhash
S
Karmanos Cancer Research Institute, School of Medicine, 9374 Scott Hall, Wayne State University, Detroit, Michigan 48201, USA. sbpadhye@chem.unipune.ernet.in
Afrasiabi
Zahra
Z
Sinn
Ekk
E
Fok
Jansina
J
Mehta
Kapil
K
Rath
Nigam
N
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry* / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D010616:Phenanthrenes; D013882:Thiosemicarbazones; C479020:phenanthrenequinone thiosemicarbazone