title: Potential fungicidal effect of voriconazole against Candida spp.
abstract: In vitro fungistatic and fungicidal activities of voriconazole were evaluated against 114 isolates of Candida spp. MICs were determined using the NCCLS M27-A2 broth microdilution method. Minimum fungicidal concentrations (MFCs) were defined as the lowest drug concentrations that yielded < or = 5 colonies (> or = 98% killing activity). The fungicidal activity could be only evaluated against 45.6% of the isolates (52 of 114 isolates) because trailing growth occurred, and 30 of these 52 isolates (57.69%) showed MFC values < or = 1 mg/l. There was little or no fungicidal activity against C. albicans and C. tropicalis. In contrast, all C. krusei were killed by 1-2 mg/l voriconazole. In conclusion, our data show that the fungicidal effect of voriconazole against Candida spp. is species dependent.
authors.affiliation: Microbiology, Hospital Clínico Universitario Lozano Blesa, Domingo Miral s/n, Zaragoza 50009, Spain. mcrubio@unizar.es
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Rubio
authors.forename: Inmaculada Ramírez
authors.initials: IR
authors.lastname: de Ocáriz
authors.forename: Joaquina
authors.initials: J
authors.lastname: Gil
authors.forename: Rafael
authors.initials: R
authors.lastname: Benito
authors.forename: Antonio
authors.initials: A
authors.lastname: Rezusta
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D041022:Candida tropicalis / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000494:pharmacology*; D013030:Spain; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole