Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript.
OBJECTIVE
To describe a tumour with morphological and immunophenotypic characteristics of epithelioid variant of pleomorphic liposarcoma. Pleomorphic liposarcoma is a very rare variant of liposarcoma defined morphologically by the presence of pleomorphic lipoblasts showing peculiar epithelial-like features that can be confused with primary or metastatic carcinoma.


RESULTS
Molecular analysis demonstrated for the first time the presence of FUS-CHOP transcript in this liposarcoma variant. Microarray analysis revealed a gene expression profile related to a more aggressive tumour type when compared with other myxoid/round cell liposarcomas.


CONCLUSIONS
The present data show that the epithelioid variant of pleomorphic liposarcoma represents a further variant of myxoid liposarcoma sharing the FUS-CHOP fusion transcript but carrying a distinct expression profile, in keeping with its aggressive clinical course.
De Cecco
L
L
FIRC Institute for Molecular Oncology Foundation, IFOM, Milano, Italy.
Gariboldi
M
M
Reid
J F
JF
Lagonigro
M S
MS
Tamborini
E
E
Albertini
V
V
Staurengo
S
S
Pilotti
S
S
Pierotti
M A
MA
D018952:Antigens, CD34 / Q000032:analysis; D015415:Biomarkers; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics*; D016000:Cluster Analysis; D003937:Diagnosis, Differential; D005260:Female; D005353:Fibronectins / Q000032:analysis; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008080:Liposarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D034702:RNA-Binding Protein FUS / Q000235:genetics*; D051499:Receptor, Fibroblast Growth Factor, Type 4; D017468:Receptors, Fibroblast Growth Factor / Q000032:analysis; D051742:Transcription Factor CHOP; D014158:Transcription, Genetic / Q000235:genetics; D014746:Vimentin / Q000032:analysis
D018952:Antigens, CD34; D015415:Biomarkers; C400901:CAM 5.2 antigen; D022762:CCAAT-Enhancer-Binding Proteins; D005353:Fibronectins; D015514:Oncogene Proteins, Fusion; D012334:RNA, Neoplasm; D034702:RNA-Binding Protein FUS; D017468:Receptors, Fibroblast Growth Factor; C106030:TLS-CHOP fusion protein, human; D014746:Vimentin; D051742:Transcription Factor CHOP; D007633:Keratins; C496371:FGFR4 protein, human; D051499:Receptor, Fibroblast Growth Factor, Type 4