title: The role of insulin and IGF-1 signaling in longevity.
abstract: There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.
authors.affiliation: Joslin Diabetes Center and Department of Medicine Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: M
authors.initials: M
authors.lastname: Katic
authors.forename: C R
authors.initials: CR
authors.lastname: Kahn
mesh_terms: D000375:Aging; D000818:Animals; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008136:Longevity / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007328:Insulin; D007334:Insulin-Like Growth Factor I