TOR signaling: an odyssey from cellular stress to the cell growth machinery.
The target of rapamycin (TOR) protein kinase is centrally involved in the coordination of cell growth and proliferation with the availability of growth factors and nutrients. Two recent reports have illuminated a mechanism whereby hypoxic stress dampens TOR signaling in metazoan cells.
Abraham
Robert T
RT
Signal Transduction Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA. abraham@burnham.org
D000818:Animals; D015687:Cell Hypoxia / Q000235:genetics; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D011494:Protein Kinases; D012097:Repressor Proteins / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins / Q000378:metabolism
D029721:Drosophila Proteins; D019869:Phosphatidylinositol 3-Kinases; D011494:Protein Kinases; D012097:Repressor Proteins; D058570:TOR Serine-Threonine Kinases; D014157:Transcription Factors; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins; C469991:DDIT4 protein, human; C498403:chrb protein, Drosophila; C498402:scyl protein, Drosophila; C416303:target of rapamycin protein, Drosophila