A case of psychosis with temporal lobe epilepsy: SPECT changes with treatment.
An 8-year-old male was referred to the child psychiatry department because of vivid visual and auditory hallucinations, including multiple voices talking to each other, and loss of consciousness. Magnetic resonance imaging scans revealed cortical dysgenesis in the left inferior frontal cortex and adjacent subcortical structures. Single-photon emission computed tomography imaging revealed left temporal hypoperfusion. Risperidone therapy was initiated because there was no remission after carbamazepine and sodium valproate treatment. After risperidone treatment, symptoms remitted. A control single-photon emission computed tomography study indicated that the left temporal hypoperfusion was normalized. After discontinuation of risperidone, symptoms returned, and electroencephalography revealed generalized slow-wave activity particularly prominent in the left temporal region. To our knowledge, this is one of the first reports of cerebral blood flow changes in a pediatric patient with psychosis after treatment.
Oner
Ozgür
O
Child Psychiatry, Ankara University Faculty of Medicine, 06690 Ankara, Turkey.
Unal
Ozlem
O
Deda
Gülhis
G
D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D002648:Child; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology*; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D018967:Risperidone / Q000494:pharmacology / Q000627:therapeutic use*; D015899:Tomography, Emission-Computed, Single-Photon
D014150:Antipsychotic Agents; D018967:Risperidone