Effect of destruction of gyrus cinguli in rat brain on the development of tolerance to the analgesic effect of morphine and physical dependence on morphine.
We studied the effect of bilateral laser destruction of rat anterior cingulate gyrus on the analgesic effect of morphine and development of tolerance and physical dependence on morphine. Bilateral laser destruction of the anterior cingulate gyrus did not modulate pain sensitivity, analgesic effect of morphine, and development of morphine tolerance. Destruction of the cingulate gyrus alleviated symptoms of the abstinence syndrome in morphine-dependent animals. We showed that morphine-induced analgesia and morphine tolerance are not associated with activity of the anterior cingulate gyrus. However, this structure plays a key role in the development of physical dependence on morphine and abstinence syndrome.
Sudakov
S K
SK
National Research Center of Narcology, Russian Ministry of Health and Social Development, Moscow, Russia. s-sudakov@mtu-net.ru
Rusakova
I V
IV
Trigub
M N
MN
Shakhmatov
V Yu
VY
Kozel
A I
AI
Smith
G E
GE
D000698:Analgesia; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D004361:Drug Tolerance / Q000502:physiology*; D006179:Gyrus Cinguli / Q000473:pathology / Q000502:physiology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D009020:Morphine