title: Human cytomegalovirus immediate-early 2 gene expression blocks virus-induced beta interferon production.
abstract: The effect of human cytomegalovirus (HCMV) gene expression on beta interferon (IFN-beta) expression was examined. We demonstrate that the HCMV immediate-early 2 (IE2) gene product IE86 can effectively block the induction of IFN-beta during HCMV infection. IE86 also efficiently blocked the induction of IFN-beta following Sendai virus infection, demonstrating that IE86's ability to block induction of IFN-beta is not limited to HCMV infection, identifying IE2 as an IFN-beta antagonist.
authors.affiliation: Department of Microbiology, University of Minnesota, 1060 Mayo Building, MMC196, Minneapolis, MN 55455, USA.
authors.forename: R Travis
authors.initials: RT
authors.lastname: Taylor
authors.forename: Wade A
authors.initials: WA
authors.lastname: Bresnahan
mesh_terms: D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000276:immunology / Q000502:physiology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics / Q000502:physiology*; D016899:Interferon-beta / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D029082:Sendai virus / Q000276:immunology; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014779:Virus Replication
chemical_list: C069186:IE2 protein, Cytomegalovirus; D017874:Immediate-Early Proteins; D015534:Trans-Activators; D016899:Interferon-beta
references.citation: Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13108-13
references.pmid: 10557281
references.citation: Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7140-5
references.pmid: 11390970
references.citation: Annu Rev Microbiol. 2001;55:255-81
references.pmid: 11544356
references.citation: J Virol. 2001 Dec;75(24):12319-30
references.pmid: 11711622
references.citation: J Virol. 2002 Sep;76(18):9545-50
references.pmid: 12186937
references.citation: Nat Rev Immunol. 2002 Sep;2(9):675-87
references.pmid: 12209136
references.citation: Science. 2003 May 16;300(5622):1145-8
references.pmid: 12702807
references.citation: J Virol. 2003 Jul;77(14):7945-56
references.pmid: 12829834
references.citation: Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11439-44
references.pmid: 12972646
references.citation: J Virol. 2004 Feb;78(3):1202-11
references.pmid: 14722275
references.citation: J Virol. 1996 Oct;70(10):6955-66
references.pmid: 8794339
references.citation: Mol Cell Biol. 1998 Jul;18(7):3796-802
references.pmid: 9632763
references.citation: Genes Dev. 1998 Jul 1;12(13):2061-72
references.pmid: 9649509
references.citation: Mol Cell. 1998 Mar;1(4):507-18
references.pmid: 9660935
references.citation: Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9837-42
references.pmid: 9707562
references.citation: Annu Rev Biochem. 1998;67:227-64
references.pmid: 9759489
references.citation: Mol Cell. 1998 Oct;2(4):457-67
references.pmid: 9809067
references.citation: J Virol. 2000 Aug;74(16):7230-7
references.pmid: 10906177
references.citation: J Virol. 2000 Nov;74(22):10816-8
references.pmid: 11044129
references.citation: Cell. 2000 Nov 10;103(4):667-78
references.pmid: 11106736
references.citation: Curr Opin Genet Dev. 2001 Apr;11(2):205-8
references.pmid: 11250145
references.citation: J Virol. 2001 Oct;75(19):8909-16
references.pmid: 11533154