Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice.
Nasal carriage is a major risk factor for Staphylococcus aureus infection, especially for methicillin-resistant strains (MRSA). Using a mouse model of nasal carriage, we have compared several S. aureus strains and demonstrated increased colonization levels by MRSA in cystic fibrosis transmembrane conductance regulator-deficient mice and Toll-like receptor 2 (TLR2)-deficient mice but not TLR4-deficient mice.
González-Zorn
Bruno
B
Unité des Agents Antibactériens, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.
Senna
Jose P M
JP
Fiette
Laurence
L
Shorte
Spencer
S
Testard
Aurélie
A
Chignard
Michel
M
Courvalin
Patrice
P
Grillot-Courvalin
Catherine
C
D000818:Animals; D002353:Carrier State / Q000382:microbiology*; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D016106:Methicillin Resistance; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018181:Mice, Inbred CFTR; D018345:Mice, Knockout; D009666:Nose / Q000382:microbiology*; D011956:Receptors, Cell Surface / Q000235:genetics; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4
D011956:Receptors, Cell Surface; C493486:Tlr2 protein, mouse; C493487:Tlr4 protein, mouse; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4
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