The role of natural killer cells in tumor control--effectors and regulators of adaptive immunity.
Natural killer (NK) cells are the primary effector cells of the innate immune system and have a well-established role in tumor rejection in a variety of spontaneous and induced cancer models. NK cell function is regulated by a complex balance of inhibitory and activating signals that allow them to selectively target and kill cells that display an abnormal pattern of cell surface molecules, while leaving normal healthy cells unharmed. In this review we discuss NK cell function, the role of NK cells in cancer therapies, the emerging concept of bi-directional cross-talk between NK cells and dendritic cells, and the implications of these interactions for tumor immunotherapy.
Wallace
Morgan E
ME
Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, 8006, East Melbourne, Victoria, Australia.
Smyth
Mark J
MJ
D000818:Animals; D002450:Cell Communication; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy
Nat Rev Immunol. 2003 Apr;3(4):304-16
12669021
Nat Med. 1999 Apr;5(4):405-11
10202929
Cytokine Growth Factor Rev. 2002 Apr;13(2):95-109
11900986
J Exp Med. 2001 Mar 19;193(6):661-70
11257133
J Leukoc Biol. 2002 Feb;71(2):173-83
11818437
J Exp Med. 2003 Aug 4;198(3):433-42
12900519
Cell. 2001 Aug 10;106(3):255-8
11509172
J Immunol. 2001 Jun 1;166(11):6477-82
11359797
Immunol Rev. 2001 Jun;181:158-69
11513137
Nature. 1997 Jul 10;388(6638):190-5
9217161
J Exp Med. 2004 Mar 15;199(6):879-84
15007091
Blood. 2001 Jan 1;97(1):192-7
11133760
J Immunol. 2000 Sep 1;165(5):2665-70
10946296
Nat Med. 1999 Nov;5(11):1249-55
10545990
J Immunol. 2001 Aug 15;167(4):2068-73
11489989
J Immunol. 2003 Jul 15;171(2):515-8
12847210
Immunity. 2003 Oct;19(4):561-9
14563320
J Exp Med. 1997 Nov 3;186(9):1609-14
9348320
Curr Top Microbiol Immunol. 1998;230:221-44
9586358
J Exp Med. 2002 Feb 4;195(3):335-41
11828008
J Immunol. 1998 Dec 1;161(11):5821-4
9834059
Eur J Immunol. 2001 Jan;31(1):39-47
11169436
Int J Cancer. 1985 Apr 15;35(4):505-13
2985510
Eur J Immunol. 1995 Dec;25(12):3514-6
8566046
Leuk Lymphoma. 1995 Aug;18(5-6):471-8
8528055
Immunol Rev. 2001 Jun;181:90-103
11513155
Nat Immunol. 2001 Sep;2(9):882-8
11526406
J Exp Med. 2000 Feb 7;191(3):423-34
10662788
Immunology. 2004 Jun;112(2):177-82
15147560
J Immunol. 2004 Jan 1;172(1):123-9
14688317
J Exp Med. 2000 Sep 4;192(5):755-60
10974040
Blood. 2004 Sep 15;104(6):1778-83
15166032
Immunity. 2000 Jul;13(1):143-53
10933402
J Immunol. 1993 Jul 1;151(1):60-70
8326140
Int Immunol. 2001 Apr;13(4):459-63
11282985
J Exp Med. 2002 Feb 4;195(3):327-33
11828007
Nat Immunol. 2002 Dec;3(12):1142-9
12426565
J Immunol. 1999 Dec 15;163(12):6365-70
10586025
J Immunol. 1998 Sep 15;161(6):2833-40
9743343
Semin Immunol. 1998 Oct;10(5):351-3
9799709
J Exp Med. 2004 Aug 2;200(3):287-95
15289500
Curr Opin Immunol. 1995 Oct;7(5):704-10
8573315
J Hematother. 1995 Aug;4(4):269-79
7489141
Anticancer Res. 2003 Nov-Dec;23(6a):4369-76
14666723
Proc Natl Acad Sci U S A. 2003 May 27;100(11):6682-7
12724523
J Immunol. 2002 Feb 1;168(3):1356-61
11801676
Pathol Biol (Paris). 2003 Mar;51(2):67-8
12801803
J Immunol. 1999 Jun 1;162(11):6658-62
10352283
J Exp Med. 2002 Feb 4;195(3):343-51
11828009
J Exp Med. 2000 Feb 21;191(4):661-8
10684858
J Exp Med. 1985 Dec 1;162(6):1745-59
3877776
J Exp Med. 1991 Apr 1;173(4):1017-20
2007850
J Immunol. 2004 Feb 1;172(3):1455-62
14734722
Nat Rev Immunol. 2001 Oct;1(1):41-9
11905813
J Exp Med. 2002 Jan 21;195(2):161-9
11805143
Immunol Today. 1995 Apr;16(4):202-6
7734049
Nat Rev Immunol. 2002 Oct;2(10):735-47
12360212
J Immunol. 2004 Jul 15;173(2):900-9
15240677
Adv Cancer Res. 2003;90:127-56
14710949
J Immunol. 2002 Oct 1;169(7):3676-85
12244160
J Exp Med. 1996 Nov 1;184(5):1845-56
8920872
J Immunol. 2002 Nov 15;169(10):5377-81
12421908
Science. 2002 Mar 15;295(5562):2097-100
11896281
Cancer Res. 1995 Jul 1;55(13):2730-3
7540948
J Exp Med. 2000 Mar 6;191(5):771-80
10704459
Nature. 2001 Sep 13;413(6852):165-71
11557981
Science. 1999 Dec 3;286(5446):1957-9
10583959
Curr Opin Oncol. 2003 Nov;15(6):440-5
14624226
Immunol Lett. 2001 Feb 1;76(1):37-41
11222911
Cancer J Sci Am. 2000 Feb;6 Suppl 1:S2-7
10685650
J Immunol. 1986 Jun 15;136(12):4480-6
3086432
Nat Rev Cancer. 2002 Nov;2(11):850-61
12415255
Int J Cancer. 2003 Feb 10;103(4):508-13
12478667
Immunity. 2003 Jan;18(1):1-6
12530970
Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10116-21
15218108
J Immunol. 2004 Feb 15;172(4):2048-58
14764669
Annu Rev Immunol. 1999;17:19-49
10358752
J Invest Dermatol. 2002 Oct;119(4):850-7
12406330
Nat Immunol. 2001 Oct;2(10):951-6
11550009
FASEB J. 1994 Oct;8(13):1012-8
7926365
Nat Med. 2001 Jan;7(1):94-100
11135622
Nat Immunol. 2002 Jan;3(1):83-90
11743585
Int J Cancer. 1975 Jun 15;15(6):933-40
1150347
Nature. 1986 Feb 20-26;319(6055):675-8
3951539
Trends Immunol. 2001 Nov;22(11):633-40
11698225
Annu Rev Immunol. 1998;16:359-93
9597134
J Immunol. 2004 Feb 1;172(3):1333-9
14734707
Nature. 1998 Mar 19;392(6673):245-52
9521319
Nat Immunol. 2001 Oct;2(10):917-24
11577347
Science. 1999 Jul 30;285(5428):727-9
10426993
J Exp Med. 2001 Sep 17;194(6):863-9
11561001
Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4778-83
10781084
Semin Immunol. 1995 Apr;7(2):89-101
7579199
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11521-6
11562472
J Natl Cancer Inst. 2004 May 5;96(9):651-3
15126597
J Allergy Clin Immunol. 1990 Feb;85(2):453-9
2303649
Immunol Res. 1998;17(1-2):269-78
9479588
Mol Immunol. 2002 Feb;38(9):637-60
11858820
Blood. 2002 Sep 1;100(5):1728-33
12176894
Eur J Immunol. 2003 Feb;33(2):306-13
12548561
Eur J Immunol. 2003 Jun;33(6):1657-66
12778484
Science. 1991 Jul 12;253(5016):199-202
1853205
Curr Opin Immunol. 2002 Oct;14(5):615-21
12183162
Immunity. 2002 Apr;16(4):559-69
11970879
Nat Rev Immunol. 2003 May;3(5):413-25
12766763
Nat Rev Immunol. 2002 Mar;2(3):151-61
11913066
Eur J Immunol. 2003 Apr;33(4):827-33
12672047
J Exp Med. 2002 Feb 4;195(3):F9-14
11828015
Nat Immunol. 2004 Dec;5(12):1260-5
15531883
J Immunol. 2002 May 1;168(9):4472-9
11970991
Trends Immunol. 2004 Jan;25(1):47-52
14698284
Cancer Res. 1994 Jul 15;54(14):3808-16
8033100
Immunity. 2003 Jul;19(1):5-8
12871634
Semin Immunol. 2002 Dec;14(6):453-60
12457618
Nat Immunol. 2002 Jun;3(6):523-8
12006976