title: Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals.
abstract: Differentiated cells of the corneal epithelium are converted to hair, along with their associated stem cells, then interfollicular epidermis, by means of a multistep process triggered by dermal developmental signals. The committed basal cells of the adult corneal epithelium dedifferentiate under the control of signals from an associated embryonic hair-forming dermis, likely Wnts, and revert to a limbal basal cell phenotype. This initial process involves the down-regulation of Pax6 and the loss of expression of corneal-specific keratins and the induction of basal keratinocyte markers. These dedifferentiated cells are able to reinduce dermal condensations, which in turn induce the formation of hair follicles from cells that have lost Pax6 expression, by means of a Noggin-dependent mechanism. An epidermis is subsequently formed by cells derived from the newly segregated hair stem cells.
authors.affiliation: Equipe Biologie de la Différenciation Epithéliale, UMR-CNRS 5538, Laboratoire d'Etude de la Différentiation et de l'Adhérence Cellulaire, Institut Albert Bonniot, Université Joseph Fourier, BP 53-38041 Grenoble Cedex 9, France.
authors.forename: David J
authors.initials: DJ
authors.lastname: Pearton
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Danielle
authors.initials: D
authors.lastname: Dhouailly
mesh_terms: D000818:Animals; D002352:Carrier Proteins; D002454:Cell Differentiation; D002455:Cell Division; D002459:Cell Fusion; D003598:Cytoskeletal Proteins / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000096:biosynthesis; D000078404:Epidermal Cells; D019573:Epithelium, Corneal / Q000166:cytology*; D005136:Eye Proteins; D018859:Hair Follicle / Q000166:cytology*; D018398:Homeodomain Proteins / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D007633:Keratins / Q000096:biosynthesis; D051821:Lymphoid Enhancer-Binding Factor 1; D051379:Mice; D008819:Mice, Nude; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011506:Proteins / Q000502:physiology; D011817:Rabbits; D012097:Repressor Proteins; D013234:Stem Cells / Q000502:physiology; D015534:Trans-Activators / Q000096:biosynthesis; D014157:Transcription Factors / Q000096:biosynthesis; D051153:Wnt Proteins; D051176:beta Catenin; D000099176:Noggin Protein
chemical_list: D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D036341:Intercellular Signaling Peptides and Proteins; D007633:Keratins; D051821:Lymphoid Enhancer-Binding Factor 1; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011506:Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D051153:Wnt Proteins; D051176:beta Catenin; D000099176:Noggin Protein; C495267:CTNNB1 protein, mouse; C000605732:Pax6 protein, mouse
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