Potential growth inhibitory effect of maitake D-fraction on canine cancer cells.
The postulated anticancer effect of D-fraction, the bioactive extract of maitake mushroom, on three types (CF33, CF21, and CL-1) of canine cancer cells was evaluated. The effect of D-fraction on several human cancer cells was also investigated. The effect of other beta-glucan products was likewise examined. D-fraction was highly effective on the canine cancer cells, either potently inhibiting cell growth or directly killing cells. Similar effects were also demonstrated in certain human cancer cells. However, other beta-glucan products relevant to D-fraction had no such effects on canine cancer cells. Therefore, D-fraction is a potent natural agent that could be useful in treating canine cancers as well as other veterinary cancers.
Konno
Sensuke
S
Department of Urology, New York Medical College, Munger Pavilion 4th Floor, Valhalla, NY, 10595, USA.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D048691:Grifola / Q000737:chemistry; D006801:Humans; D007694:Killer Cells, Natural; D009369:Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D014407:Tumor Cells, Cultured; D047071:beta-Glucans / Q000494:pharmacology*
D000970:Antineoplastic Agents; D047071:beta-Glucans