[Chlamydia pneumoniae infection increases the risk of coronary artery disease in the patients with dyslipidemia].
OBJECTIVE
To investigates the role of chlamydia pneumoniae (CP) infection in the development of coronary artery disease (CAD) in the patients with dyslipidemia, and to examine the gender related differences in this role.


METHODS
523 inpatients with dyslipidemia and 1196 inpatients without dyslipidemia tested for specific CP IgG by enzyme-linked immunoassay. Multivariate analyses were performed in the patients with and without dyslipidemia, and in the subgroups of male and female dyslipidemic patients to get the adjusted odds ratio (OR) (95% confidence intervals) of CAD for a given risk factor.


RESULTS
After adjusting for age over 55 years, male sex, smoking, hypertension and diabetes, the OR of CAD associated with CP infection was 2.5 (1.4 to 4.6, P = 0.002) in the patients with dyslipidemia, and was 0.967 (0.7 - 1.4, P = 0.851) in those without dyslipidemia. In comparison with the male patients with dyslipidemia, the adjusted OR of CAD was 2.1 (1.1 to 4.1) for CP infection and 3.3 (1.9 - 5.9) for smoking; only CP infection was significantly contributed to CAD in female dylipidemic patients, with an adjusted OR of 4.4 (1.4 to 14.6).


CONCLUSIONS
CP infection increases the risk of CAD only in patients with dyslipidemia, and this increase was greater in women than in men.
Sun
Yu-hua
YH
Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.
Pei
Wei-dong
WD
Wu
Yong-jian
YJ
Ye
Shao-dong
SD
Wang
Guo-gan
GG
Gao
Run-lin
RL
Yang
Yue-jin
YJ
D000368:Aged; D023521:Chlamydophila Infections / Q000150:complications*; D016993:Chlamydophila pneumoniae; D003324:Coronary Artery Disease / Q000209:etiology* / Q000382:microbiology; D050171:Dyslipidemias / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D018410:Pneumonia, Bacterial / Q000150:complications; D012307:Risk Factors