Frequency-specific cochlear damage in guinea pig after exposure to different types of realistic industrial noise.
For the causal evaluation of occupational hearing damage it is important to identify definitely the noise source. Here we tested, whether recordings of distortion product otoacoustic emissions (DPOAEs) in awake guinea pigs can distinguish the effects of different industrial noises. Six groups of 12 animals each were investigated before and over four months after a single 2 h exposure to specific, played-back industrial noise as well as before and for 2 months after impulse noise exposure. We compared broadband noise (buzz saw, bottle washing machine), low frequency noise (drawing press), and mid-frequency noise (bottle filling machine). All animals had stable DPOAE levels before noise exposure. Frequency specific decreases in DPOAEs were found after exposure to the different noises. Broadband noise diminished mostly all frequencies tested, whereas low- or mid-frequency noise had a greater effect on DPOAE evoked by middle and higher frequencies, respectively. DPOAE evoked by middle and higher frequencies were obliterated after impulse noise. Morphological analysis of the cochleae confirmed these alterations. OHC loss was found in the middle turns of the cochleae corresponding to the diminution of DPOAE. We conclude that different kinds of industrial noise tend to produce typical changes in DPOAE levels.
Emmerich
Edeltraut
E
Institute of Physiology-Neurophysiology, Friedrich Schiller University Jena, Teichgraben 8, D-07740 Jena, Germany. EEMM@mti.uni-jena.de
Richter
Frank
F
Linss
Volker
V
Linss
Werner
W
D000818:Animals; D001309:Auditory Threshold; D003051:Cochlea / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure; D006317:Hearing Loss, Noise-Induced / Q000473:pathology* / Q000503:physiopathology / Q000517:prevention & control; D008855:Microscopy, Electron, Scanning; D009622:Noise / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects / Q000145:classification; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology