[Increased subthalamic neuronal activity after dorsal raphe nucleus lesion by 5,7-dihydroxytryptamine in the rat].
In vivo extracellular recordings were made in the subthalamic nucleus (STN) of intact control rats and rats with 5,7-dihydroxytryptamine (5,7-DHT) -produced lesion of dorsal raphe nucleus (DRN). The results showed that the firing rate of STN neurons in control rats and DRN-lesioned rats were (6.93+/-6.55) Hz and (11.27+/-9.31) Hz, respectively, and the firing rate of DRN-lesioned rats significantly increased when compared to the control rats (P<0.01). In control rats, 13% of STN neurons discharged regularly, 46% irregularly and 41% in bursts. In DRN-lesioned rats, 9% of STN neurons discharged regularly, 14% irregularly and 77% in bursts, the percentage of STN neurons firing in bursts was obviously higher than that of the control rats (P<0.01). In addition, the mean interspike interval coefficient of variation of STN neurons in control rats and DRN-lesioned rats were (0.05+/-0.04) and (0.11+/-0.09), respectively. The mean interspike interval coefficient of variation of DRN-lesioned rats was significantly higher than that of the control rats (P<0.001). These results show that the firing rate and the bursting pattern rate of neurons in STN of DRN-lesioned rats increase significantly, suggesting that DRN inhibits the neuronal activity of the subthalamic neurons in the intact rat.
Liu
Jian
J
Department of Physiology, School of Medicine, Xi'an Jiao Tong University, Xi'an 710061, China. liujian@mail.xjtu.edu.cn
Chu
Yu-Xia
YX
Feng
Jie
J
Wang
Yong
Y
Zhang
Qiao-Jun
QJ
Xu
Lin-Ping
LP
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D018663:Adrenergic Agents / Q000494:pharmacology; D000818:Animals; D055724:Electrophysiological Phenomena; D008297:Male; D009474:Neurons / Q000502:physiology*; D011897:Random Allocation; D011903:Raphe Nuclei / Q000187:drug effects / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020531:Subthalamic Nucleus / Q000503:physiopathology*
D018663:Adrenergic Agents; D015116:5,7-Dihydroxytryptamine