Pycnogenol stimulates lipolysis in 3t3-L1 cells via stimulation of beta-receptor mediated activity.
The influence of pycnogenol on the glycerol released into the medium in fully differentiated 3T3-L1 cells was studied. After incubation for 2 h, pycnogenol stimulated glycerol release in a dose-dependent manner. Pretreatment with the beta-receptor antagonist, propranolol, significantly reduced pycnogenol-induced lipolysis in a dose-dependent manner. When fully differentiated 3T3-L1 cells were incubated with pycnogenol, the cyclic adenosine monophosphate content significantly increased. These data suggested that pycnogenol has strong lipolytic effects via stimulation of beta-receptor mediated activity.
Mochizuki
Miyako
M
Department of Health and Nutrition, School of Health and Human Life, Nagoya Bunri University, Inazawa, Japan.
Hasegawa
Noboru
N
D041721:3T3-L1 Cells / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005990:Glycerol / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008066:Lipolysis / Q000187:drug effects*; D051379:Mice; D008517:Phytotherapy; D028223:Pinus; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D005419:Flavonoids; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D011943:Receptors, Adrenergic, beta; C024070:pycnogenols; D005990:Glycerol