Finding the hematopoietic stem cell niche in the placenta.
The origin of definitive hematopoiesis poses a fundamental biological question. In this issue of Developmental Cell, two groups have independently found a novel hematopoietic stem cell (HSC) niche in the extraembryonic placenta, in addition to previously identified alternative locations of hematopoiesis at different developmental stages.
Li
Linheng
L
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA.
D000818:Animals; D018952:Antigens, CD34 / Q000276:immunology; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology / Q000502:physiology; D006413:Hematopoietic System / Q000166:cytology* / Q000196:embryology; D051379:Mice; D010920:Placenta / Q000166:cytology*; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism
D018952:Antigens, CD34; D019009:Proto-Oncogene Proteins c-kit