title: Vasoplegic syndrome after off-pump coronary artery bypass surgery: an unusual complication.
abstract: We report the case of a 65-year-old man who developed norepinephrine-resistant vasoplegic syndrome after elective off-pump coronary artery bypass surgery (OPCAB). The failure of norepinephrine to improve the patient's hemodynamics prompted us to start treatment with vasopressin; within 30 minutes, the hemodynamics began to improve. After 12 hours, the patient was stable enough to be weaned from the vasopressin. He was discharged from the hospital on the 10th postoperative day. To our knowledge, ours is the 1st report of vasopressin use for vasodilatory shock after OPCAB in the English-language medical literature. Herein, we discuss the pathophysiology and management of vasoplegic syndrome--which is controversial--with special emphasis on the use of vasopressin in this situation.
authors.affiliation: Department of Cardiac Surgery, Harefield Hospital, Middlesex, United Kingdom. drrajashahzad@hotmail.com
authors.forename: Shahzad G
authors.initials: SG
authors.lastname: Raja
authors.forename: Gilles D
authors.initials: GD
authors.lastname: Dreyfus
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D016534:Cardiac Output, High / Q000188:drug therapy / Q000209:etiology*; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D006801:Humans; D007022:Hypotension / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D013577:Syndrome; D013610:Tachycardia / Q000188:drug therapy / Q000209:etiology*; D014655:Vascular Resistance / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000627:therapeutic use; D014667:Vasopressins / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents; D014667:Vasopressins
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