Leucine aminopeptidase M inhibitors, cyanostatin A and B, isolated from cyanobacterial water blooms in Scotland.
Two leucine aminopeptidase M inhibitors, cyanostatin A and B, were isolated from cyanobacterial water blooms at Loch Rescobie in Scotland, and specifically from a Microcystis species. Both inhibitors were lipopeptides containing 3-amino-2-hydroxydecanoic acid and weak inhibitors of protein phosphatase (PP2A). Both strongly inhibited the activity of leucine aminopeptidase M with IC50 values of 40 and 12 ng/ml, respectively.
Sano
Tomoharu
T
National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan. sanotomo@nies.go.jp
Takagi
Hiroo
H
Morrison
Louise F
LF
Metcalf
James S
JS
Codd
Geoffrey A
GA
Kaya
Kunimitsu
K
D017033:Anabaena; D000458:Cyanobacteria / Q000302:isolation & purification*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D007700:Kinetics; D007931:Leucyl Aminopeptidase / Q000037:antagonists & inhibitors*; D046931:Microcystis; D009842:Oligopeptides / Q000302:isolation & purification / Q000494:pharmacology*; D014871:Water Microbiology
D004791:Enzyme Inhibitors; D009842:Oligopeptides; C500517:cyanostatin A; C500516:cyanostatin B; D007931:Leucyl Aminopeptidase