title: [Results of the Collaborative Initial Glaucoma Treatment Study (CIGTS)].
abstract: The Collaborative Initial Glaucoma Treatment Study (CIGTS) was initiated to evaluate whether local medical therapy or trabeculectomy is the better initial treatment for patients with newly diagnosed open-angle glaucoma. Visual field progression, intraocular pressure, and visual acuity were to be monitored for a period of 5 years. A total of 607 patients were randomly distributed among the two groups and controlled at 6-month intervals. At the same time the investigators tried to record quality of life using a questionnaire. Both trabeculectomy and medical therapy were able to lower intraocular pressure significantly, whereas trabeculectomy was more effective. The results of the questionnaire showed only minor differences between the two groups. The medically treated patients reported slightly more ocular symptoms than the patients in the trabeculectomy group.
authors.affiliation: Augenklinik, Universität, Mainz. jochen.wahl@uni-mainz.de
authors.forename: J
authors.initials: J
authors.lastname: Wahl
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D018450:Disease Progression; D017889:Exfoliation Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D009896:Optic Atrophy / Q000175:diagnosis / Q000517:prevention & control; D010043:Outcome and Process Assessment, Health Care; D011788:Quality of Life; D012086:Reoperation; D014130:Trabeculectomy; D014787:Vision Tests; D014794:Visual Fields / Q000187:drug effects
chemical_list: D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions
references.citation: Am J Ophthalmol. 1998 Oct;126(4):498-505
references.pmid: 9780094
references.citation: Arch Ophthalmol. 1999 Sep;117(9):1137-42
references.pmid: 10496384
references.citation: Curr Opin Ophthalmol. 2003 Apr;14(2):106-11
references.pmid: 12698052
references.citation: Ophthalmology. 2001 May;108(5):887-97; discussion 898
references.pmid: 11320018
references.citation: Arch Ophthalmol. 2002 Jun;120(6):701-13; discussion 829-30
references.pmid: 12049574
references.citation: Arch Ophthalmol. 2003 Jan;121(1):48-56
references.pmid: 12523884
references.citation: Am J Ophthalmol. 2000 Oct;130(4):429-40
references.pmid: 11024415
references.citation: Am J Ophthalmol. 1996 Jun;121(6):605-14
references.pmid: 8644802
references.citation: Ophthalmology. 1999 Apr;106(4):653-62
references.pmid: 10201583
references.citation: Ophthalmology. 2001 Nov;108(11):1954-65
references.pmid: 11713062
references.citation: Ophthalmology. 2001 Nov;108(11):1943-53
references.pmid: 11713061