title: Use of recombinant factor VII to control bleeding in a patient supported by right ventricular assist device after heart transplantation.
abstract: A 48-year-old man undergoing orthotopic heart transplantation for ischemic cardiomyopathy developed severe right heart failure. Severe intractable bleeding complicated implantation of a right ventricular assist device. Treatment with 9.6 mg of recombinant activated factor VII stopped the bleeding, and the patient could be transferred to the intensive care unit. This is the first reported case of the successful use of recombinant activated factor VII to control bleeding with subsequent right ventricular assist device function.
authors.affiliation: Department of Cardiothoracic Surgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel. akogan@clalit.org.il
authors.forename: Alexander
authors.initials: A
authors.lastname: Kogan
authors.forename: Marius
authors.initials: M
authors.lastname: Berman
authors.forename: Ygal
authors.initials: Y
authors.lastname: Kassif
authors.forename: Ehud
authors.initials: E
authors.lastname: Raanani
authors.forename: Alon
authors.initials: A
authors.lastname: Stamler
authors.forename: Tuvia
authors.initials: T
authors.lastname: Ben Gal
authors.forename: Michael
authors.initials: M
authors.lastname: Stein
authors.forename: Eldad
authors.initials: E
authors.lastname: Erez
authors.forename: Bernardo A
authors.initials: BA
authors.lastname: Vidne
authors.forename: Gideon
authors.initials: G
authors.lastname: Sahar
mesh_terms: D009202:Cardiomyopathies / Q000628:therapy; D005167:Factor VII / Q000008:administration & dosage / Q000627:therapeutic use*; D015942:Factor VIIa; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D014914:Whole Blood Coagulation Time
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa