Long-chain polyunsaturated fatty acids in childhood developmental and psychiatric disorders.
Both omega-3 and omega-6 long-chain PUFA (LC-PUFA) are crucial to brain development and function, but omega-3 LC-PUFA in particular are often lacking in modern diets in developed countries. Increasing evidence, reviewed here, indicates that LC-PUFA deficiencies or imbalances are associated with childhood developmental and psychiatric disorders including ADHD, dyslexia, dyspraxia, and autistic spectrum disorders. These conditions show a high clinical overlap and run in the same families, as well as showing associations with various adult psychiatric disorders in which FA abnormalities are already implicated, such as depression, other mood disorders, and schizophrenia. Preliminary evidence from controlled trials also suggests that dietary supplementation with LC-PUFA might help in the management of these kinds of childhood behavioral and learning difficulties. Treatment with omega-3 FA appears most promising, but the few small studies published to date have involved different populations, study designs, treatments, and outcome measures. Large-scale studies are now needed to confirm the benefits reported. Further research is also required to assess the durability of such treatment effects, to determine optimal treatment compositions and dosages, and to develop reliable ways of identifying those individuals most likely to benefit from this kind of treatment. Childhood developmental and psychiatric disorders clearly reflect multifactorial influences, but the study of LC-PUFA and their metabolism could offer important new approaches to their early identification and management. Heterogeneity and comorbidity are such, however, that a focus on specific traits or symptoms may prove more fruitful than an exclusive reliance on current diagnostic categories.
Richardson
Alexandra J
AJ
University Lab of Physiology and Mansfield College, Oxford, United Kindgdom. alex.richardson@physiol.ox.ac.uk
D001921:Brain / Q000166:cytology / Q000502:physiology; D002648:Child; D002658:Developmental Disabilities / Q000209:etiology*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000209:etiology*; D016032:Randomized Controlled Trials as Topic
D015525:Fatty Acids, Omega-3
Eur J Clin Nutr. 2004 Mar;58(3):467-73
14985685
J Nutr. 1998 Feb;128(2 Suppl):427S-433S
9478042
J Am Acad Child Adolesc Psychiatry. 2000 Nov;39(11):1424-31
11068898
Biomed Pharmacother. 2002 Oct;56(8):365-79
12442909
Psychol Med. 1987 Feb;17(1):121-43
3554290
Lancet. 1995 Aug 5;346(8971):385
7623560
Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):233-9
11817499
Am J Clin Nutr. 2000 Jan;71(1 Suppl):367S-72S
10617999
J Neurochem. 1996 Apr;66(4):1582-91
8627314
Arch Gen Psychiatry. 1999 May;56(5):407-12
10232294
Med Hypotheses. 1995 Dec;45(6):605-13
8771057
Nutrition. 2002 Sep;18(9):786
12297226
J Lipid Res. 2001 Aug;42(8):1257-65
11483627
Adv Neuroimmunol. 1996;6(2):119-29
8876768
J Child Psychol Psychiatry. 2000 Nov;41(8):1039-48
11099120
Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):47-59
10970713
Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):79-87
10970718
Trends Neurosci. 1997 Apr;20(4):147-52
9106353
Schizophr Res. 2001 Apr 30;49(3):243-51
11356585
J Autism Dev Disord. 2002 Aug;32(4):337-45
12199139
Neurosci Lett. 1998 Jan 16;240(3):177-81
9502233
J Nutr Biochem. 2001 Jan;12(1):21-32
11179858
Can J Psychiatry. 2003 Apr;48(3):195-203
12728744
Prostaglandins Leukot Essent Fatty Acids. 2001 Mar;64(3):173-80
11334553
Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):69-74
10970716
J Psychiatr Res. 2002 Jan-Feb;36(1):7-18
11755456
J Child Psychol Psychiatry. 1996 Feb;37(2):225-7
8682903
J Am Acad Child Adolesc Psychiatry. 1995 Aug;34(8):1025-32
7665441
Lipids. 2001 Sep;36(9):885-95
11724460
Cochrane Database Syst Rev. 2001;(4):CD000376
11687076
Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):33-6
10970710
Am J Clin Nutr. 2000 Jan;71(1 Suppl):275S-84S
10617983
J Mol Neurosci. 2001 Apr-Jun;16(2-3):237-42; discussion 279-84
11478379
Eur Neuropsychopharmacol. 2003 Aug;13(4):267-71
12888186
Lipids. 2003 Oct;38(10):1007-21
14669965
J Neurosci Res. 1999 Jun 15;56(6):565-70
10374811
J Affect Disord. 1998 Jun;49(3):211-9
9629951
Am J Clin Nutr. 1995 Oct;62(4):761-8
7572706
Biol Psychiatry. 1981 Sep;16(9):837-50
7028146
Am J Psychiatry. 1987 Mar;144(3):330-3
3826433
J Clin Invest. 1996 Feb 15;97(4):1129-33
8613538
Physiol Behav. 1996 Apr-May;59(4-5):915-20
8778886
Science. 2000 Dec 15;290(5499):2155-9
11118151
Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):61-3
10970714
J Pediatr. 1994 Nov;125(5 Pt 2):S39-47
7965452
Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):75-8
10970717
Am J Clin Nutr. 2000 Jan;71(1 Suppl):323S-6S
10617990
Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):21-5
10970708
Diabetes Metab. 2003 Jun;29(3):289-95
12909818
Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):95-100
10970720
J Child Psychol Psychiatry. 1994 Oct;35(7):1255-71
7806609
Am J Psychiatry. 2003 Jan;160(1):167-9
12505817
J Am Acad Child Adolesc Psychiatry. 1999 Jul;38(7):820-8
10405499
Am J Psychiatry. 2003 May;160(5):996-8
12727707
Lipids. 2003 Apr;38(4):323-41
12848277
J Biol Chem. 2003 Apr 25;278(17):14677-87
12590139
Br J Nutr. 2002 Oct;88(4):411-20
12323090
Biol Psychiatry. 1989 Jan 15;25(2):222-8
2539203
Ann N Y Acad Sci. 2000;917:456-67
11268373
Med Hypotheses. 1981 May;7(5):673-9
7196985
Lipids. 2003 Apr;38(4):343-52
12848278
Int J Neuropsychopharmacol. 2002 Dec;5(4):345-56
12466034
Prostaglandins Other Lipid Mediat. 2004 Apr;73(3-4):155-72
15290791
Clin Pediatr (Phila). 1987 Aug;26(8):406-11
2439249
J Learn Disabil. 1985 Dec;18(10):581-4
4086934
Behav Brain Res. 2004 Jun 4;152(1):49-57
15135968
Prostaglandins Leukot Essent Fatty Acids. 2004 Apr;70(4):383-90
15041031
Am J Clin Nutr. 2000 Jan;71(1 Suppl):327S-30S
10617991
Lipids. 1989 Dec;24(12):1014-9
2615569
J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug;33(6):894-903
8083147
World Rev Nutr Diet. 2003;92:23-36
14579681
Prostaglandins Leukot Essent Fatty Acids. 2001 Jul;65(1):1-7
11487301
Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):37-9
10970711
Prostaglandins Leukot Essent Fatty Acids. 2000 Jul-Aug;63(1-2):1-9
10970706
J Abnorm Child Psychol. 1987 Mar;15(1):75-90
3553274
J Pediatr. 2001 Aug;139(2):189-96
11487742
Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun;60(5-6):407-10
10471130
J Am Acad Child Adolesc Psychiatry. 1989 Nov;28(6):882-7
2808258
Neuropsychobiology. 2002;46(2):76-84
12378124
Am J Psychiatry. 2002 Mar;159(3):477-9
11870016
Br J Nutr. 2002 Oct;88(4):355-63
12323085
Arch Gen Psychiatry. 2002 Oct;59(10 ):913-9
12365878
Hum Psychopharmacol. 2004 Aug;19(6):397-403
15303243
Proc Soc Exp Biol Med. 1987 Jul;185(3):291-6
3037555