title: Biocompatibility of titanium implants modified by microarc oxidation and hydroxyapatite coating.
abstract: A thin hydroxyapatite (HA) layer was coated on a microarc oxidized titanium (MAO-Ti) substrate by means of the sol-gel method. The microarc oxidation (anodizing) enhanced the biocompatibility of the Ti, and the bioactivity was improved further by the sol-gel HA coating on the anodized Ti. The HA sol was aged fully to obtain a stable and phase-pure HA, and the sol concentration was varied to alter the coating thickness. Through the sol-gel HA coating, the Ca and P concentrations in the coating layer increased significantly. However, the porous morphology and roughness of the MAO-Ti was altered very little by the sol-gel treatment. The proliferation and alkaline phosphatase (ALP) activity of the osteoblast-like cells on the MAO/HA sol-gel-treated Ti were significantly higher than those on the MAO-Ti without the HA sol-gel treatment.
authors.affiliation: School of Materials Science and Engineering, Seoul National University, Seoul 151-742, Korea.
authors.forename: Long-Hao
authors.initials: LH
authors.lastname: Li
authors.forename: Hae-Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Su-Hee
authors.initials: SH
authors.lastname: Lee
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Kong
authors.forename: Hyoun-Ee
authors.initials: HE
authors.lastname: Kim
mesh_terms: D020341:Absorbable Implants; D000469:Alkaline Phosphatase / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010084:Oxidation-Reduction; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D017886:Durapatite; D014025:Titanium; D000469:Alkaline Phosphatase