Pigmented-anaerobic bacteria associated with canine periodontitis.
The etiology of human periodontal disease has been the focus of considerable research, yet relatively little is known about the causative agents of companion animal periodontitis. In humans, Porphyromonas gingivalis, a black-pigmented anaerobic bacteria (BPAB), has been implicated as the primary periopathogen. It has been demonstrated that BPAB are also found in companion animal periodontal pockets. While some animal BPAB have been individually identified, a study to identify the most frequently isolated subgingival BPAB has not been completed using genetic tools. The objective of this work was to identify the types and relative frequencies of pigmented anaerobic bacteria found in the periodontal pockets of dogs. Porphyromonas salivosa, Porphyromonas denticanis (a novel species) and Porphyromonas gulae were found to be the most frequently isolated BPAB associated with canine periodontitis.
Hardham
John
J
Pfizer Inc., Veterinary Medicine Research and Development, 301 Henrietta Street, Kalamazoo, MI 49001, USA. john_m_hardham@pfizer.com
Dreier
Kimberly
K
Wong
Jason
J
Sfintescu
Cornelia
C
Evans
Richard T
RT
D000818:Animals; D016866:Bacteroidaceae Infections / Q000382:microbiology / Q000662:veterinary*; D001483:Base Sequence; D001681:Biological Assay / Q000662:veterinary; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010518:Periodontitis / Q000382:microbiology / Q000662:veterinary*; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000662:veterinary; D017861:Porphyromonas / Q000235:genetics / Q000302:isolation & purification*; D012336:RNA, Ribosomal, 16S / Q000737:chemistry / Q000235:genetics
D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S