title: Experimental cortical dysplasia following ibotenate administration in hamsters: pathogenesis of microgyria and associated gray matter heterotopia.
abstract: The study presented here investigated the pathogenetic relationship among different types of neuronal migration disorders occurring simultaneously in the brain using an experimental model induced by ibotenate in hamsters. In the cerebral cortex, abnormal neuronal arrangement was induced 1 day after ibotenate injection. This brain lesion resulted in microgyria in the rostral portion, focal subcortical heterotopia in the mid-portion, and focal subependymal heterotopia in the caudal portion in the same specimen. Vimentin-immunoreactive radial glial fibers were lacking in the area of disorganized neuronal arrangement, but were detected around the microgyria and the intermediate zone surrounding focal subcortical heterotopia. The focal subependymal heterotopia did not include radial glial elements. Glial fibrillary acidic protein (GFAP)-positive glial reaction was weak in these cortical lesions. We suggest that the occurrence of each type of migration disorder depends on the depth of the cortical lesion, that is, the production of microgyria, focal subcortical heterotopia and focal subependymal heterotopia are closely related to the lesions including the cortical plate, subplate and ventricular zone, respectively.
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Japan. tmyktkn@belle.shiga-med.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Takano
authors.forename: Chihiro
authors.initials: C
authors.lastname: Sawai
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sakaue
authors.forename: Shoichi
authors.initials: S
authors.lastname: Takikita
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism / Q000473:pathology*; D006224:Cricetinae; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007051:Ibotenic Acid / Q000008:administration & dosage / Q000633:toxicity*; D009457:Neuroglia / Q000187:drug effects / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists; D014746:Vimentin / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D016194:Receptors, N-Methyl-D-Aspartate; D014746:Vimentin; D007051:Ibotenic Acid