Effect of Betula bark extract on spontaneous and induced mutagenesis in mice.
Study was performed by counting cells with chromosomal aberrations in C57Bl/6 mice. Bark dry extract was given perorally in doses of 50, 150, 450, and 1500 mg/kg. Mutagens dioxidine and cyclophosphamide were injected intraperitoneally in doses of 200 and 20 mg/kg, respectively. Bark dry extract in doses of 150 and 1500 mg/kg did not possess cytogenetic activity. Bark dry extract in doses of 50, 150, and 450 mg/kg significantly decreased the cytogenetic effect of mutagens under various regimens of treatment with the preparation (single combined administration, 5-day pretreatment, and 5-day combined administration). Our results indicate that bark dry extract possesses antimutagenic properties.
Zhanataev
A K
AK
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. pharmacol@yandex.ru
Presnova
G A
GA
Chistyakov
A N
AN
Durnev
A D
AD
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D029662:Betula; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D009153:Mutagens / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology*
D016587:Antimutagenic Agents; D009153:Mutagens; D010936:Plant Extracts