Hantavirus pulmonary syndrome in Central Bolivia: relationships between reservoir hosts, habitats, and viral genotypes.
In August 2002, two cases of hantavirus pulmonary syndrome (HPS) were confirmed in Mineros and Concepcion, within the Santa Cruz Department of Bolivia. Extensive alteration of the native ecosystem, from dense forest to pasture or sugarcane, had occurred in both regions. An ecologic assessment of reservoir species associated with the human disease identified a single hantavirus antibody-positive Oligoryzomys microtis from Mineros and three hantavirus antibody-positive Calomys callosus from Concepcion. In Mineros, the virus from the O. microtis was 90% similar to sequences published for Rio Mamore virus. Viral nucleotide sequences from two C. callosus were 87-88% similar to the sequence of Laguna Negra virus. The viral sequence from the C. callosus was 99% identical to viral sequences obtained from the HPS patient in this area, implicating C. callosus as the host and Laguna Negra virus as the agent responsible for the HPS case near Concepcion.
Carroll
Darin S
DS
Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. dcarroll@cdc.gov
Mills
James N
JN
Montgomery
Joel M
JM
Bausch
Daniel G
DG
Blair
Patrick J
PJ
Burans
James P
JP
Felices
Vidal
V
Gianella
Alberto
A
Iihoshi
Naomi
N
Nichol
Stuart T
ST
Olson
James G
JG
Rogers
Duke S
DS
Salazar
Milagros
M
Ksiazek
Thomas G
TG
D000818:Animals; D001838:Bolivia / Q000453:epidemiology; D004197:Disease Reservoirs; D005838:Genotype; D006476:Orthohantavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D018804:Hantavirus Pulmonary Syndrome / Q000097:blood / Q000453:epidemiology* / Q000635:transmission*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012377:Rodentia / Q000821:virology*
D012367:RNA, Viral