title: The effects of the dopamine D1 receptor antagonist SCH23390 on memory reconsolidation following reminder-activated retrieval in day-old chicks.
abstract: This series of experiments examined the involvement of the dopamine D1 receptor antagonist, SCH23390, on memory reconsolidation following reminder-activated retrieval. Day-old male New HampshirexWhite Leghorn chicks were trained on a single trial passive avoidance task. A dose of 0.5 mg/kg of SCH23390 was administered subcutaneously 5 min before reminder trials, which were presented at 30, 60, and 90 min following training. Memory deficits were observed when reminder trials were presented at 30 and 60 min following training, but not when a reminder was presented at 90 min. No effect on memory retention was observed when reminder trials were not presented, suggesting that reconsolidation mechanisms were both contingent on the presentation of the reminder and independent of the consolidation process. Following a reminder presented at 60 min post-training, deficits in memory retention emerged between 45 and 60 min. The deficit was prolonged, lasting for up until 48 h after reminder presentation. The results indicate an important role for the D1 receptor in reconsolidation processes.
authors.affiliation: School of Psychological Science, La Trobe University, Bundoora 3086, Australia.
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Sherry
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Hale
authors.forename: Simon F
authors.initials: SF
authors.lastname: Crowe
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001552:Benzazepines / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002645:Chickens; D003463:Cues; D017362:Cyclic AMP Response Element-Binding Protein / Q000502:physiology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D007279:Injections, Subcutaneous; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology; D008297:Male; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors* / Q000502:physiology; D012153:Retention, Psychology / Q000187:drug effects* / Q000502:physiology
chemical_list: D001552:Benzazepines; D017362:Cyclic AMP Response Element-Binding Protein; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1