Human cytomegalovirus immediate-early 2 gene expression blocks virus-induced beta interferon production.
The effect of human cytomegalovirus (HCMV) gene expression on beta interferon (IFN-beta) expression was examined. We demonstrate that the HCMV immediate-early 2 (IE2) gene product IE86 can effectively block the induction of IFN-beta during HCMV infection. IE86 also efficiently blocked the induction of IFN-beta following Sendai virus infection, demonstrating that IE86's ability to block induction of IFN-beta is not limited to HCMV infection, identifying IE2 as an IFN-beta antagonist.
Taylor
R Travis
RT
Department of Microbiology, University of Minnesota, 1060 Mayo Building, MMC196, Minneapolis, MN 55455, USA.
Bresnahan
Wade A
WA
D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000276:immunology / Q000502:physiology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics / Q000502:physiology*; D016899:Interferon-beta / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D029082:Sendai virus / Q000276:immunology; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014779:Virus Replication
C069186:IE2 protein, Cytomegalovirus; D017874:Immediate-Early Proteins; D015534:Trans-Activators; D016899:Interferon-beta
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