Peptide-cleaving catalyst selective for peptide deformylase.
A peptide-cleaving catalyst selective for peptide deformylase (PDF) was obtained from a library containing about 15 000 catalyst candidates. The catalyst cleaved the polypeptide backbone of PDF at Gln(152)-Arg(153). Docking simulations suggested multiple modes of interactions in the complex formed between the catalyst and PDF.
Chae
Pil Seok
PS
Department of Chemistry, Seoul National University, Seoul 151-747, Korea.
Kim
Myoung-Soon
MS
Jeung
Chul-Seung
CS
Lee
Seong Du
SD
Park
Hwangseo
H
Lee
Sangyoub
S
Suh
Junghun
J
D000577:Amides / Q000737:chemistry*; D000581:Amidohydrolases / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry*; D011487:Protein Conformation; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D000577:Amides; D009942:Organometallic Compounds; C442399:cyclencobalt(III); D003035:Cobalt; D000581:Amidohydrolases; C084507:peptide deformylase