[Bronchoobstructive syndrome in bronchoectasias].
OBJECTIVE
To specify mechanisms of bronchial obstruction in bronchoectasia (BE).


METHODS
Clinical, x-ray, bronchological and spirographic examinations with broncholytic test were made in 26 BE patients aged 16-66 years (14 males, 12 females). The membrane-receptor complex of erythrocytes was based on the effect of adrenoantagonist propranolol on osmotic erythrocytic resistance (obsidan test) and effect of adrenoagonist adrenalin on dynamics of ESR.


RESULTS
Allergological anamnesis was detected in 69% of BE patients, hereditary allergological anamnesis--in 22%, membrane-receptor changes characteristic for atopic condition by obsidan test--in 46%, fractional erythrocytic sedimentation with adrenalin--in 42%. Bronchoobstruction syndrome occurred in 37% cases with mean values FEV1 46 +/- 6.2%, MSV50 17.4 +/- 3%, MSV75 14.4 +/- 0.9%. The broncholytic test detected a mean increment of FEV1 by 12.2 +/- 3.1%. Latent bronchospasm was revealed in 33% patients with BE.


CONCLUSIONS
The correlation analysis suggests that among mechanisms of bronchial obstruction in bronchoectasia, bronchospasm is of great importance especially in allergological anamnesis pathogenesis of which involves disorders of membrane-receptor complex.
Bondarchul
V V
VV
Korovina
O V
OV
Mineev
V N
VN
D000293:Adolescent; D000328:Adult; D000368:Aged; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D016084:Bronchoconstriction; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D011943:Receptors, Adrenergic, beta