title: High incidence of Kaposi sarcoma-associated herpesvirus infection in HIV-related solid immunoblastic/plasmablastic diffuse large B-cell lymphoma.
abstract: Kaposi sarcoma-associated herpesvirus (KSHV) is known to be associated with two distinct lymphoproliferative disorders: primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD)/MCD-associated plasmablastic lymphoma. We here report a high incidence of KSHV infection in solid HIV-associated immunoblastic/plasmablastic non-Hodgkin's lymphomas (NHLs), in patients lacking effusions and without evidence of (prior) MCD. Within a cohort of 99 HIV-related NHLs, 10 cases were found to be KSHV positive on the basis of immunostaining for KSHV LNA-1 as well as KSHV-specific polymerase chain reaction. All but one of the tumors coexpressed Epstein-Barr virus. Interestingly, all KSHV-positive cases belonged to a distinctive subgroup of 26 diffuse large B-cell lymphomas characterized by the expression of CD138 (syndecan-1) and plasmablastic/immunoblastic morphology. These KSHV-positive lymphomas were preceded by Kaposi sarcoma in 60% of the patients and involved the gastrointestinal tract in 80%. Our results indicate that KSHV infection is not restricted to PEL and MCD; it is also common (38%) in HIV-related solid immunoblastic/plasmablastic lymphomas.
authors.affiliation: Department of Pathology Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: S T P
authors.initials: ST
authors.lastname: Deloose
authors.forename: L A
authors.initials: LA
authors.lastname: Smit
authors.forename: F T
authors.initials: FT
authors.lastname: Pals
authors.forename: M-J
authors.initials: MJ
authors.lastname: Kersten
authors.forename: C J M
authors.initials: CJ
authors.lastname: van Noesel
authors.forename: S T
authors.initials: ST
authors.lastname: Pals
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000453:epidemiology / Q000821:virology*; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D016130:Immunophenotyping; D015994:Incidence; D016483:Lymphoma, AIDS-Related / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012514:Sarcoma, Kaposi / Q000453:epidemiology / Q000821:virology*