title: Junctional epidermolysis bullosa in two domestic shorthair kittens.
abstract: This article describes two cases of junctional epidermolysis bullosa in nonrelated kittens. Both cats exhibited pinnal erosions, oral ulcerations and severe onychomadesis. Histopathology, electron microscopy and/or indirect immunoperoxidase revealed subepidermal clefting, with the lamina densa remaining attached to the floor of the vesicles. Indirect immunofluorescence revealed reduced staining for laminin-5 gamma2 subunit in case 1 and beta3 subunit in case 2.
authors.affiliation: Clinique Vétérinaire, Cidex 248, RN 85, 06330 Roquefort les Pins, France. z.alhaidari@wanadoo.ft
authors.forename: Zeineb
authors.initials: Z
authors.lastname: Alhaidari
authors.forename: Thierry
authors.initials: T
authors.lastname: Olivry
authors.forename: Anne
authors.initials: A
authors.lastname: Spadafora
authors.forename: Randall C
authors.initials: RC
authors.lastname: Thomas
authors.forename: Christophe
authors.initials: C
authors.lastname: Perrin
authors.forename: Guerrino
authors.initials: G
authors.lastname: Meneguzzi
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Ortonne
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D016109:Epidermolysis Bullosa, Junctional / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007797:Laminin / Q000096:biosynthesis; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary
chemical_list: D007797:Laminin