Metabolic investigation of patients with urolithiasis in a specific region.
OBJECTIVE
To assess the prevalence of the main metabolic alterations found in patients with recent diagnosis of urolithiasis in the West region of Parana state, Brazil.


METHODS
We made a retrospective study on 425 patients with evidence of recent formation of renal stones. Laboratory assessment consisted in 3 samples of 24-hour urine with dosing of calcium, uric acid, citrate, oxalate, sodium and creatinine. A urine culture was also made and qualitative cystinuria and urinary pH following 12-hour fasting and water restriction were evaluated.


RESULTS
In 96.5% of patients a cause was detected for the urolithiasis. Metabolic alterations most frequently found were: hypercalciuria (38.3%), hypocitraturia (29.6%) and hyperexcretion of uric acid (21.6%). Low urinary volume (17.9%), urinary tract infection (12.9%), hyperparathyroidism (3.3%), renal tubular acidosis (1.2%), cystinuria (0.9%) and anatomical alterations (12.7%) were also observed.


CONCLUSIONS
Hypercalciuria, hypocitraturia and hyperuricuria are the most frequent metabolic disorders in the population under study and these data are in accordance to the literature.
Peres
Luis A B
LA
State University of West Paraná, UNIOESTE, Cascavel, Paraná, Brazil. peres@certto.com.br
Molina
André S
AS
Galles
Marcos H L
MH