Pelvic magnetic resonance imaging after bone marrow harvest--a retrospective study in 50 unrelated marrow donors.
A total of 50 unrelated marrow donors were examined by pelvic magnetic resonance imaging (MRI) to investigate the morphological sequelae of bone marrow harvesting (BMH). Signal increase in T2-weighted sequences and contrast media enhancement in T1 sequences at the operative sites were found as typical MRI morphology 4 weeks after harvest (group A, n=16), corresponding to edema, hyperemia and proliferative activity. Although tissue repair was completed in the majority of donors 1 year after BMH, about 36% of donors in group B (n=16) had abnormal findings. These included a persistence of the 'acute injury' signal pattern (2/16, 12%), and signal alterations due to fatty marrow conversion (4/16, 24%). The proportion of MRI abnormalities increased to over 70% in two-time donors (group C, n=11), which might indicate a cumulation of tissue damage after repetitive harvests. If donors had experienced prolonged discomfort after BMH (group D, n=7), MRI revealed pathological signals in 86%. In conclusion, the MRI morphology reflects the pathophysiological reactions after BMH, including inflammation and tissue repair. A further prospective evaluation in a larger number of donors is necessary to confirm these results and to identify the factors which influence the extent and duration of tissue damage.
Kroschinsky
F
F
University Hospital Dresden, 1st Medical Department, Dresden, Germany. kroschinsky@mk1.med.tu-dresden.de
Kittner
T
T
Mauersberger
S
S
Rautenberg
U
U
Schuler
U
U
Rutt
C
C
Laniado
M
M
Ehninger
G
G
D000328:Adult; D001853:Bone Marrow / Q000293:injuries / Q000473:pathology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010388:Pelvis; D012189:Retrospective Studies; D014019:Tissue Donors; D014945:Wound Healing