title: Histopathology of long-term Cardona keratoprosthesis: a case report.
abstract: OBJECTIVE
  To report histologic findings of a Cardona keratoprosthesis (KPro) in an eye enucleated after 14 years.
  
  
  METHODS
  Case report of a 56-year-old male whose KPro was implanted following bilateral chemical burns. Following enucleation, histopathology by light and transmission electron microscopy was performed.
  
  
  RESULTS
  The prosthesis was retained in the eye until clinical complications including retinal detachment necessitated enucleation after 14 years. Histopathology confirmed a total retinal detachment, necrosis of the detached retina, inflammation, and foreign-body reaction in the Dacron mesh. Calcification was not seen.
  
  
  CONCLUSIONS
  PMMA is a suitable material for an optic and provides for good postoperative acuity. The complex skirt area may be predisposed to long-term inflammation. Less complicated surgery and a simple inert device with a flange with good mechanical and biologic integration may help in reducing postoperative complications.
authors.affiliation: Lions Eye Institute and Centre for Ophthalmology and Visual Science, University of Western Australia, Nedlands, Western Australia, Australia. Sarojini@cyllene.uwa.edu.au
authors.forename: Sarojini
authors.initials: S
authors.lastname: Vijayasekaran
authors.forename: Terry
authors.initials: T
authors.lastname: Robertson
authors.forename: Celia
authors.initials: C
authors.lastname: Hicks
authors.forename: Lawrence
authors.initials: L
authors.lastname: Hirst
mesh_terms: D001672:Biocompatible Materials; D002057:Burns, Chemical / Q000601:surgery; D003315:Cornea; D005126:Eye Burns / Q000139:chemically induced; D015353:Eye Enucleation; D005549:Foreign-Body Reaction / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011093:Polyethylene Terephthalates; D019904:Polymethyl Methacrylate; D011183:Postoperative Complications; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D012163:Retinal Detachment / Q000209:etiology / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D019904:Polymethyl Methacrylate