The role of apoptosis in cancer development and treatment response.
The inactivation of programmed cell death, or apoptosis, is central to the development of cancer. This disabling of apoptotic responses might be a major contributor both to treatment resistance and to the observation that, in many tumours, apoptosis is not the main mechanism for the death of cancer cells in response to common treatment regimens. Importantly, this suggests that other modes of cell death are involved in the response to therapy.
Brown
J Martin
JM
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford, California 94305, USA. mbrown@stanford.edu
Attardi
Laura D
LD
D017209:Apoptosis; D016923:Cell Death / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology* / Q000628:therapy*; D016159:Tumor Suppressor Protein p53
D016159:Tumor Suppressor Protein p53