Mitochondria, oxidants, and aging.
The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging.
Balaban
Robert S
RS
Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA.
Nemoto
Shino
S
Finkel
Toren
T
D000375:Aging / Q000502:physiology*; D000818:Animals; D005609:Free Radicals / Q000378:metabolism*; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D009154:Mutation / Q000235:genetics / Q000502:physiology; D009747:Nutritional Physiological Phenomena / Q000502:physiology; D016877:Oxidants / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015003:Yeasts
D005609:Free Radicals; D016877:Oxidants; D017382:Reactive Oxygen Species