title: Intensity-modulated radiotherapy: is xerostomia still prevalent?
abstract: Conformal radiation with intensity-modulated radiotherapy (IMRT) is a technique that potentially can minimize the dose to salivary glands and thereby decrease the incidence of xerostomia. Precise target determination and delineation is most important when using salivary gland-sparing techniques of IMRT. Reduction of xerostomia can be achieved by sparing the salivary glands on the uninvolved oral cavity and keeping the mean parotid gland dose of less than 26 to 30 Gy as a planning criterion if the treatment of disease is not compromised and parotid function preservation is desired.
authors.affiliation: Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009, USA. mchamber@mdanderson.org
authors.forename: Mark S
authors.initials: MS
authors.lastname: Chambers
authors.forename: Adam S
authors.initials: AS
authors.lastname: Garden
authors.forename: David
authors.initials: D
authors.lastname: Rosenthal
authors.forename: Anesa
authors.initials: A
authors.lastname: Ahamad
authors.forename: David L
authors.initials: DL
authors.lastname: Schwartz
authors.forename: Angel I
authors.initials: AI
authors.lastname: Blanco
authors.forename: K S Clifford
authors.initials: KS
authors.lastname: Chao
authors.forename: William H
authors.initials: WH
authors.lastname: Morrison
authors.forename: K Kian
authors.initials: KK
authors.lastname: Ang
authors.forename: Randal S
authors.initials: RS
authors.lastname: Weber
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D004307:Dose-Response Relationship, Radiation; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy; D010307:Parotid Neoplasms / Q000532:radiotherapy; D015995:Prevalence; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods*; D012469:Salivary Glands / Q000528:radiation effects; D014987:Xerostomia / Q000453:epidemiology* / Q000209:etiology
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