[Virus-induced expression of type I interferon genes].
Intracellular double-stranded (ds) RNA is a major sign of replication for many viruses. Host mechanisms detect the dsRNA and provoke antiviral responses. Recently, we identified retinoic acid inducible gene-I (RIG-I), which encodes a DExD/H box RNA helicase containing the caspase recruitment domain (CARD) as a critical regulator for dsRNA-induced signaling. The helicase domain with intact ATPase activity is responsible for recognition of dsRNA, and the CARD transmits downstream signals, resulting in the activation of genes including type I interferons. In this review, we discuss the function of RIG-I in antiviral innate immunity.
Yoneyama
Mitsutoshi
M
Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research 3-18-22, Honkomagome, Bunkyo-ku, Tokyo 113-8613 Japan. yoneyama@rinshoken.or.jp
Fujita
Takashi
T
D000251:Adenosine Triphosphatases; D000818:Animals; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D015967:Gene Expression Regulation, Viral; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007370:Interferon Type I / Q000235:genetics*; D011401:Promoter Regions, Genetic; D017434:Protein Structure, Tertiary; D020365:RNA Helicases / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000502:physiology; D012330:RNA, Double-Stranded / Q000276:immunology; D011971:Receptors, Immunologic; D017471:Receptors, Interferon / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000502:physiology; D018406:Virus Physiological Phenomena; D014779:Virus Replication / Q000235:genetics* / Q000276:immunology*
D007370:Interferon Type I; D012330:RNA, Double-Stranded; D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D014157:Transcription Factors; D000251:Adenosine Triphosphatases; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases