title: The development of a plant-based vaccine for measles.
abstract: Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.
authors.affiliation: Children's Vaccines Group, MacFarlane Burnet Institute for Medical Research and Public Health, P.O. Box 2284, Melbourne, Vic. 3001, Australia. diane@burnet.edu.au
authors.forename: D E
authors.initials: DE
authors.lastname: Webster
authors.forename: M C
authors.initials: MC
authors.lastname: Thomas
authors.forename: Z
authors.initials: Z
authors.lastname: Huang
authors.forename: S L
authors.initials: SL
authors.lastname: Wesselingh
mesh_terms: D000284:Administration, Oral; D000818:Animals; D006388:Hemagglutinins / Q000276:immunology; D006801:Humans; D007117:Immunization, Secondary; D008457:Measles / Q000453:epidemiology / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D030781:Organisms, Genetically Modified; D030821:Plants, Genetically Modified / Q000276:immunology*
chemical_list: D006388:Hemagglutinins; D008458:Measles Vaccine