title: T cell immunity in hepatitis B and hepatitis C virus infection: implications for autoimmunity.
abstract: T cells are involved in the pathogenesis of important liver diseases including both autoimmune liver diseases and viral hepatitis. In addition to playing a crucial role in the control of hepatitis viruses, T cell responses are also responsible for the liver injury during acute and chronic phases of viral hepatitis. In this article, we reviewed current literature on T cell immunity to hepatitis B and C viruses. In addition, antigen presenting cells that are critical for T cell immunity against these viruses are also discussed. This will provide insights to the understanding of T cell immunity in autoimmune liver diseases due to the similar role of T cells in autoimmune liver diseases and viral hepatitis.
authors.affiliation: Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, TB192, One Shields Avenue, Davis, CA 95616, USA.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ichiki
authors.forename: Xiao-Song
authors.initials: XS
authors.lastname: He
authors.forename: Shinji
authors.initials: S
authors.lastname: Shimoda
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Emmet B
authors.initials: EB
authors.lastname: Keeffe
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Rossaro
authors.forename: M Eric
authors.initials: ME
authors.lastname: Gershwin
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology; D015551:Autoimmunity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D006509:Hepatitis B / Q000276:immunology* / Q000473:pathology; D006526:Hepatitis C / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008099:Liver / Q000276:immunology / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology