[Lipid peroxidation and activity of antioxidant enzymes in thyroidectomized rats].
The effect of thymalin on peroxidation of lipids in thyroidectomized rats that received thyroxin at a dose 2 mg/ kg was examined. It was found that 3 months after operation a decrease in body weight (over 2 times), weight of spleen and amount of cells in it took place. An increase of TB-activated products in livers and spleens of thyroidectomized rats 3 month later was not essential. Indices of enzyme activity of antioxidant system in liver were within normal ranges while indices of activity of catalase and superoxidedysmuthase in spleen increased by 4,3 and 1,3 times, respectively. Simultaneous administration of thyroxin and thymalin promotes more effective normalization of POL peroxidation, inhibits development of pathologic changes in organism after removal of thyroid gland.
Hrinevych
Iu Ia
IuIa
Bendiuh
H D
HD
Bilokin'
Iu M
IuM
Trembach
O M
OM
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism*; D004359:Drug Therapy, Combination; D020249:Hormone Replacement Therapy / Q000379:methods*; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism*; D013951:Thymus Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D013965:Thyroidectomy; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use
D000975:Antioxidants; D008054:Lipid Peroxides; D013951:Thymus Hormones; C032805:thymalin; D002374:Catalase; D013482:Superoxide Dismutase; D013974:Thyroxine