title: Efficient preparation of 2-indolyl-1-nitroalkane derivatives employing nitroalkenes as versatile Michael acceptors: new practical linear approach to alkyl 9h-beta-carboline-4-carboxylate.
abstract: The combination of cerium(III) chloride heptahydrate and sodium iodide supported on silica gel is known to promote Michael-type additions. Continuing our work on solvent-free conditions, the CeCl3.7H2O-NaI-SiO2 system catalyzes the addition of a variety of indoles and nitroalkenes, giving 2-indolyl-1-nitroalkane derivatives in good yields. Development of this method has resulted in a new protocol for the synthesis of 4-substituted beta-carbolines.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Camerino, via S. Agostino 1, I-62032 Camerino (MC), Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bartoli
authors.forename: Marcella
authors.initials: M
authors.lastname: Bosco
authors.forename: Sandra
authors.initials: S
authors.lastname: Giuli
authors.forename: Arianna
authors.initials: A
authors.lastname: Giuliani
authors.forename: Laura
authors.initials: L
authors.lastname: Lucarelli
authors.forename: Enrico
authors.initials: E
authors.lastname: Marcantoni
authors.forename: Letizia
authors.initials: L
authors.lastname: Sambri
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Torregiani
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis*; D000475:Alkenes / Q000737:chemistry*; D002243:Carbolines / Q000138:chemical synthesis*; D002264:Carboxylic Acids / Q000138:chemical synthesis*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis*
chemical_list: D000473:Alkanes; D000475:Alkenes; D002243:Carbolines; D002264:Carboxylic Acids; D009574:Nitro Compounds