title: Imbalance in expression levels of insulin-like growth factor 2 and H19 transcripts linked to progression of hepatocellular carcinoma.
abstract: BACKGROUND
  The imprinted genes insulin-like growth factor 2 (IGF2) and H19 play important roles in various malignancies including hepatocellular carcinoma (HCC).
  
  
  METHODS
  We used DNA microarray and patient follow-up data to examine the relationship between expression of IGF2 and H19 and HCC.
  
  
  RESULTS
  We found that imbalances in levels of IGF2 and H19 transcripts were correlated with advanced tumor stage and poor outcome in HCC patients.
  
  
  CONCLUSIONS
  In addition to their known epigenetic or genetic abnormality in malignancies, these findings suggest that altered transcription of these two imprinted genes contributes to progression of HCC.
authors.affiliation: Department of Surgery II, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Iizuka
authors.forename: Masaaki
authors.initials: M
authors.lastname: Oka
authors.forename: Takao
authors.initials: T
authors.lastname: Tamesa
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hamamoto
authors.forename: Hisafumi
authors.initials: H
authors.lastname: Yamada-Okabe
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000096:biosynthesis* / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020411:Oligonucleotide Array Sequence Analysis; D062085:RNA, Long Noncoding; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D022661:RNA, Untranslated / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C094335:H19 long non-coding RNA; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D022661:RNA, Untranslated; D007335:Insulin-Like Growth Factor II