title: [Effect of selenium on liver type I deiodinase in iodine-excess mice].
abstract: OBJECTIVE
  To investigate the effect of selenium on the activities of liver type I deiodinase (IDI) in iodine-excess mice.
  
  
  METHODS
  Forty female weanling Balb/c mice of 18-22 body weight were randomly divided into 5 groups: normal control group (N, deionized water), iodine-excess group I (IE I, 3 mg/L Iodine water), IE I + Se group (+ 1 mg/L Se water), iodine-excess group II (IE II, 5 mg/L Iodine water) and IE II + Se group (+ 1 mg/L Se water), and they were fed with standard diets and different level of iodine and selenium water for 12 weeks.
  
  
  RESULTS
  Iodine-excess groups show diffused colloid goiter; Serum TT4 of two iodine-excess groups were significantly higher than Normal control, and TT3 of IE II decreased significantly; The selenium level and IDI activity of mice liver was decreased significantly in iodine-excess group, but no difference between IE I and IE II.
  
  
  CONCLUSIONS
  Iodine-excess intake can decrease the selenium level and IDI activity of mice liver, which maybe is the reason to increase the serum TT4 level and lead to goiter, and selenium can alleviate that.
authors.affiliation: Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Hou
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Pang
authors.forename: Xuzhao
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhenying
authors.initials: Z
authors.lastname: Qi
authors.forename: Dong
authors.initials: D
authors.lastname: Yu
authors.forename: Xiufa
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D005260:Female; D006042:Goiter / Q000139:chemically induced; D007453:Iodide Peroxidase / Q000378:metabolism*; D007455:Iodine / Q000008:administration & dosage / Q000009:adverse effects*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D012643:Selenium / Q000494:pharmacology*
chemical_list: D007455:Iodine; D007453:Iodide Peroxidase; D012643:Selenium