title: VDUP1 is required for the development of natural killer cells.
abstract: Vitamin D3 upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)2D3 in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1-/- mice). VDUP1-/- mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1-/- mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1-/- mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo.
authors.affiliation: Laboratory of Immunology, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon 305-333, Republic of Korea.
authors.forename: Kee Nyung
authors.initials: KN
authors.lastname: Lee
authors.forename: Hyung-Sik
authors.initials: HS
authors.lastname: Kang
authors.forename: Jun-Ho
authors.initials: JH
authors.lastname: Jeon
authors.forename: Eun-Mi
authors.initials: EM
authors.lastname: Kim
authors.forename: Suk-Ran
authors.initials: SR
authors.lastname: Yoon
authors.forename: Hyunkeun
authors.initials: H
authors.lastname: Song
authors.forename: Chil-Youl
authors.initials: CY
authors.lastname: Lyu
authors.forename: Zheng-Hao
authors.initials: ZH
authors.lastname: Piao
authors.forename: Sun-Uk
authors.initials: SU
authors.lastname: Kim
authors.forename: Ying-Hao
authors.initials: YH
authors.lastname: Han
authors.forename: Su-Sung
authors.initials: SS
authors.lastname: Song
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Lee
authors.forename: Kyu-Sang
authors.initials: KS
authors.lastname: Song
authors.forename: Yong-Man
authors.initials: YM
authors.lastname: Kim
authors.forename: Dae-Yeul
authors.initials: DY
authors.lastname: Yu
authors.forename: Inpyo
authors.initials: I
authors.lastname: Choi
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D002454:Cell Differentiation; D002460:Cell Line; D017353:Gene Deletion; D005786:Gene Expression Regulation; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D013879:Thioredoxins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D015375:Receptors, Interleukin-2; C445672:Txnip protein, mouse; D013879:Thioredoxins