title: Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: a prospective study.
abstract: To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80 degrees C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total omega-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), alpha-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of omega-6 polyunsaturated fatty acids on colorectal cancer risk were detected.
authors.affiliation: Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. masayok@med.nagoya-cu.ac.jp
authors.forename: Masayo
authors.initials: M
authors.lastname: Kojima
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Shinkan
authors.initials: S
authors.lastname: Tokudome
authors.forename: Koji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Koji
authors.initials: K
authors.lastname: Tamakoshi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Miyuki
authors.initials: M
authors.lastname: Kawado
authors.forename: Shuji
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Norihiko
authors.initials: N
authors.lastname: Hayakawa
authors.forename: Kotaro
authors.initials: K
authors.lastname: Ozasa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Toyoshima
authors.forename: Sadao
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002849:Chromatography, Gas; D015179:Colorectal Neoplasms / Q000097:blood*; D004281:Docosahexaenoic Acids / Q000097:blood; D005227:Fatty Acids / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D004281:Docosahexaenoic Acids; C026219:docosapentaenoic acid