Leucopenia and thrombocytopenia possibly associated with lamotrigine use in a patient.
Haematological side effects are rather exceptional with lamotrigine. We report the case of a 25-year-old woman with epilepsy who developed combined leucopenia and thrombocytopenia eight weeks after starting lamotrigine. Within weeks after lamotrigine was discontinued, all of the haematopoietic abnormalities had disappeared. To our knowledge, this is the first report of combined leucopenia and thrombocytopenia associated with lamotrigine treatment suggesting, in our patient, a causal reaction.
Ural
Ali Ugur
AU
Department of Haematology, Medical and Cancer Research Center, Gulhane Military Medical Academy, School of Medicine, Ankara, Turkey. aural@gata.edu.tr
Avcu
Ferit
F
Gokcil
Zeki
Z
Nevruz
Oral
O
Cetin
Turker
T
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced* / Q000150:complications; D010976:Platelet Count; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications; D014227:Triazines / Q000009:adverse effects*
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine