Development of vasculature targeting strategies for the treatment of chronic inflammatory diseases.
The pathogenesis of a number of chronic inflammatory processes can be attributed to prolonged neovascularization. This article reviews recent studies on the vasculature targeting strategies for the treatment of chronic inflammatory diseases. Targeting of the vasculature of inflamed organs could underlie a new pharmacological approach in the treatment of inflammatory diseases by taking advantage of formulations that deliver drugs to blood vessels specifically located at disease sites and to inflammatory cells.
Ranieri
Girolamo
G
National Cancer Institute, Department of Clinical and Experimental Oncology, Bari, Italy.
Ria
Roberto
R
Roccaro
Aldo M
AM
Vacca
Angelo
A
Ribatti
Domenico
D
D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000473:pathology*; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology*; D007962:Leukocytes / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000473:pathology*
D020533:Angiogenesis Inhibitors