title: SNP haplotypes in the angiotensin I-converting enzyme (ACE) gene: analysis of Nigerian family data using gamete competition models.
abstract: Gamete competition models were used to explore the relationships between 13 ACE gene polymorphisms and plasma ACE concentration in a set of Nigerian families. Several markers in the 5' and 3' regions of the gene were significantly associated with ACE concentration (P < 10(-4)). Multi-locus genotypes comprising different combinations of markers from the 5' UTR and the 3' region of the gene were also analysed; in addition to G2350A, in the 3' region, two markers from the 5' UTR (A-5466C and A-240T) were found to be associated with ACE concentration. These results are consistent with reports that have suggested the presence of at least two ACE-linked QTLs, and demonstrate the utility of gamete competition models in the exploratory investigation of the relationship between a quantitative trait and multiple variants in a small genomic region.
authors.affiliation: Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica, West Indies. colin.mckenzie02@uwimona.edu.jm
authors.forename: C A
authors.initials: CA
authors.lastname: McKenzie
authors.forename: J S
authors.initials: JS
authors.lastname: Sinsheimer
authors.forename: A A
authors.initials: AA
authors.lastname: Adeyemo
authors.forename: R D
authors.initials: RD
authors.lastname: Cox
authors.forename: L
authors.initials: L
authors.lastname: Southam
authors.forename: A
authors.initials: A
authors.lastname: Hugill
authors.forename: N
authors.initials: N
authors.lastname: Bouzekri
authors.forename: M
authors.initials: M
authors.lastname: Lathrop
authors.forename: T E
authors.initials: TE
authors.lastname: Forrester
authors.forename: R S
authors.initials: RS
authors.lastname: Cooper
authors.forename: R
authors.initials: R
authors.lastname: Ward
mesh_terms: D000328:Adult; D005260:Female; D005854:Germ Cells; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009549:Nigeria; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D007703:Peptidyl-Dipeptidase A