Transient depression of excitatory synapses on interneurons contributes to epileptiform bursts during gamma oscillations in the mouse hippocampal slice.
Persistent gamma frequency (30-70 Hz) network oscillations occur in hippocampal slices under conditions of metabotropic glutamate receptor (mGluR) activation. Excessive mGluR activation generated a bistable pattern of network activity during which epochs of gamma oscillations of increasing amplitude were terminated by synchronized bursts and very fast oscillations (>70 Hz). We provide experimental evidence that, during this behavior, pyramidal cell-to-interneuron synaptic depression takes place, occurring spontaneously during the gamma rhythm and associated with the onset of epileptiform bursts. We further provide evidence that excitatory postsynaptic potentials (EPSPs) in pyramidal cells are potentiated during the interburst gamma oscillation. When these two types of synaptic plasticity are incorporated, phenomenologically, into a network model previously shown to account for many features of persistent gamma oscillations, we find that epochs of gamma do indeed alternate with epochs of very fast oscillations and epileptiform bursts. Thus the same neuronal network can generate either gamma oscillations or epileptiform bursts, in a manner depending on the degree of network drive and network-induced fluctuations in synaptic efficacies.
Traub
Roger D
RD
Departments of Physiology and Pharmacology, and Neurology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA. roger.traub@downstate.edu
Pais
Isabel
I
Bibbig
Andrea
A
Lebeau
Fiona E N
FE
Buhl
Eberhard H
EH
Garner
Helen
H
Monyer
Hannah
H
Whittington
Miles A
MA
D000818:Animals; D003198:Computer Simulation; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology* / Q000502:physiology; D066298:In Vitro Techniques; D007395:Interneurons / Q000502:physiology*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives; D051379:Mice; D008810:Mice, Inbred C57BL; D008959:Models, Neurological; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D009991:Oscillometry; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D013569:Synapses / Q000145:classification / Q000502:physiology*; D013997:Time Factors
D008734:Methoxyhydroxyphenylglycol; C010117:3,4-dihydroxyphenylglycol