Clinicopathological comparison between young and old age patients with gastric adenocarcinoma.
BACKGROUND
There are controversies regarding the differences in the clinicopathological characteristics of gastric cancer between young and older patients. Our aim was to establish clinicopathological differences between both groups.


METHODS
Records of all Jordanian patients with gastric adenocarcinoma managed at our hospitals between 1991 and 2001 were reviewed. Patients were divided into two groups according to their age; young patients (<or=40 yr of age; n=17), and older patients (>40 yr of age; n=159). The clinicopathological features and overall survival data for both groups were retrospectively analyzed and compared.


RESULTS
In the young group, in comparison with older group, females were more predominant (p=0.049), family history of gastric cancer was more common (p=0.006), proximal location and involvement of the entire stomach were more (p<0.001), and diffuse cancers (65% vs 13%) and poorly differentiated carcinomas (47% vs 26%) were more prevalent. Advanced tumor stage was the same in both groups (65% vs 64%, ns). There was no significant difference in survival between young and old patients (p=0.287). However, age was significantly associated with survival when treated as a continuous variable even after adjusting for the effects of site and stage of tumor on survival. The probability of death was increased by 5.6% with each yr of age.


CONCLUSIONS
Special features of gastric cancer differ significantly between young and older age groups. Greater awareness of early-onset gastric cancer is mandatory for detecting cancer early enough so that it is treated successfully.
Bani-Hani
Kamal E
KE
Department of Surgery, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid-Jordan. mailto:banihani60@yahoo.com
D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D007597:Jordan; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology*; D016019:Survival Analysis
Ann Surg Oncol. 2000 Aug;7(7):515-9
10947020
Hepatogastroenterology. 1999 Jul-Aug;46(28):2690-3
10522066
N Engl J Med. 2001 Jun 21;344(25):1904-9
11419427
Cancer. 1987 Apr 1;59(7):1362-5
3815307
Int J Mol Med. 2000 Feb;5(2):185-90
10639599
Endoscopy. 2003 Jan;35(1):61-7
12510228
Public Health. 2002 Jan;116(1):39-44
11896635
Int J Cancer. 1999 Mar 15;80(6):827-41
10074914
Acta Pathol Microbiol Scand. 1965;64:31-49
14320675
Cancer. 1999 Jun 15;85(12):2506-11
10375095
Jpn J Cancer Res. 1999 Sep;90(9):993-9
10551330
J Am Coll Surg. 1999 Jan;188(1):22-6
9915238
Scand J Gastroenterol. 2000 Mar;35(3):255-9
10766317
Histopathology. 2003 Feb;42(2):128-36
12558744
Zentralbl Chir. 2002 Apr;127(4):270-4
12085274
World J Gastroenterol. 2004 Aug 1;10(15):2174-8
15259060
Br J Surg. 1985 Apr;72(4):289-91
3986480
Am J Clin Oncol. 1996 Feb;19(1):45-8
8554035
Zhonghua Wai Ke Za Zhi. 1999 Mar;37(3):154-6
11829807
Hepatogastroenterology. 2001 Nov-Dec;48(42):1552-5
11813570
Aliment Pharmacol Ther. 2000 Oct;14 Suppl 3:48-54
11050487
Eur J Obstet Gynecol Reprod Biol. 1999 Nov;87(1):13-22
10579611
J Cancer Res Clin Oncol. 2000 Apr;126(4):233-7
10782897
Oncol Rep. 2001 May-Jun;8(3):633-6
11295093
Ann Surg Oncol. 2000 Jun;7(5):346-51
10864341
CA Cancer J Clin. 1999 Jan-Feb;49(1):33-64, 1
10200776
Mol Pathol. 2000 Aug;53(4):207-10
11040944
Histopathology. 2000 Aug;37(2):124-30
10931235
Med J Malaysia. 2000 Mar;55(1):135-7
11072499
J Surg Oncol. 1999 Aug;71(4):214-9
10440758
Am J Surg. 1996 Nov;172(5):473-6; discussion 476-7
8942547
Hepatogastroenterology. 1996 Sep-Oct;43(11):1273-80
8908562
Rev Gastroenterol Mex. 1999 Apr-Jun;64(2):75-7
10532131
Rev Gastroenterol Peru. 2000 Oct-Dec;20(4):384-394
12140573
Zhonghua Wai Ke Za Zhi. 1997 May;35(5):271-3
10374558
Postgrad Med J. 1999 Jan;75(879):22-6
10396582
Aust N Z J Surg. 1999 Jun;69(6):443-6
10392889
Surgery. 2001 Oct;130(4):612-7; discussion 617-9
11602891
Zhonghua Zhong Liu Za Zhi. 1999 May;21(3):224-6
11776843