title: A case of idiopathic sclerosing mediastinitis in a 7-year-old Japanese boy.
abstract: Sclerosing mediastinitis is a very rare benign disorder characterised by the development of dense fibrous tissue within the mediastinum. Affected patients are typically young adults with infant cases being uncommon especially in areas without endemic histoplasmosis. We report a Japanese boy with markedly elevated serum inflammatory markers for more than 1 year in the absence of any clinical manifestations. 67Ga-scintigraphy demonstrated an accumulation in the mediastinal region and an open biopsy revealed a hard fibrous mass in the anteriosuperior mediastinum. Thus, a diagnosis of idiopathic sclerosing mediastinitis was made.
  
  
  CONCLUSIONS
  To the best of our knowledge, this case is the youngest patient reported with this disorder. In patients with mediastinal mass lesions the diagnosis of sclerosing mediastinitis should be considered as well as infectious, autoimmune or neoplastic disease even in children.
authors.affiliation: Department of Paediatrics, Nara Medical University, 840 Shijo-cho, 634-8522 Kashihara City, Nara, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shinkawa
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Nakajima
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kishimoto
authors.forename: Jiro
authors.initials: J
authors.lastname: Inagaki
authors.forename: Young-Dong
authors.initials: YD
authors.lastname: Park
authors.forename: Keiji
authors.initials: K
authors.lastname: Kushibe
authors.forename: Shigeki
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakagawa
authors.forename: Akira
authors.initials: A
authors.lastname: Yoshioka
mesh_terms: D000740:Anemia / Q000209:etiology; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007564:Japan; D008297:Male; D008480:Mediastinitis / Q000175:diagnosis* / Q000601:surgery; D008482:Mediastinum / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011877:Radionuclide Imaging; D012598:Sclerosis
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G; D002097:C-Reactive Protein
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