Effects of Lantana camara (Verbenaceae) on general reproductive performance and teratology in rats.
Lantana camara L. (Verbenaceae) possesses several medicinal properties and it is used in folk medicine with antipyretic, antimicrobial and antimutagenic properties. This plant is one of the 10 most noxious weeds in the world. Lantana poisoning have caused severe economic losses and was the major cause of livestock mortality and morbidity. In this article we report the effects of hydroalcoholic extract from Lantana camara var. aculeata leaves on fertility, general reproductive performance and teratology in the rat. The data showed that the extract interfered in the frequency of fetal skeleton anomalies from dams treated with the extract and induced embryotoxicity as indicated by post-implantation loss, without any signs of maternal toxicity. The other parameters evaluated did not suggest modifications.
Mello
Fernanda B
FB
Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul, UFRGS, Av. Sarmento Leite n. 500, sala 202, Porto Alegre, RS, 90046-900, Brazil.
Jacobus
Daniela
D
Carvalho
Kelly
K
Mello
João R B
JR
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000818:Animals; D001835:Body Weight; D001938:Brazil; D005260:Female; D005298:Fertility / Q000187:drug effects*; D048788:Growth and Development / Q000187:drug effects*; D032410:Lantana / Q000737:chemistry*; D008431:Maternal-Fetal Exchange; D009929:Organ Size; D010936:Plant Extracts / Q000633:toxicity; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*
D010936:Plant Extracts