title: A self-assembling protein template for constrained synthesis and patterning of nanoparticle arrays.
abstract: Self-assembling biomolecules that form highly ordered structures have attracted interest as potential alternatives to conventional lithographic processes for patterning materials. Here, we introduce a general technique for patterning nanoparticle arrays using two-dimensional crystals of genetically modified hollow protein structures called chaperonins. Constrained chemical synthesis of transition metal nanoparticles is initiated using templates functionalized with polyhistidine sequences. These nanoparticles are ordered into arrays because the template-driven synthesis is constrained by the nanoscale structure of the crystallized protein. We anticipate that this system may be used to pattern different classes of nanoparticles based on the growing library of sequences shown to specifically bind or direct the growth of materials.
authors.affiliation: NASA Ames Research Center, Moffett Field, California 94035, USA.
authors.forename: R Andrew
authors.initials: RA
authors.lastname: McMillan
authors.forename: Jeanie
authors.initials: J
authors.lastname: Howard
authors.forename: Nestor J
authors.initials: NJ
authors.lastname: Zaluzec
authors.forename: Hiromi K
authors.initials: HK
authors.lastname: Kagawa
authors.forename: Rakesh
authors.initials: R
authors.lastname: Mogul
authors.forename: Yi-Fen
authors.initials: YF
authors.lastname: Li
authors.forename: Chad D
authors.initials: CD
authors.lastname: Paavola
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Trent
mesh_terms: D000497:Alloys / Q000737:chemistry*; D019843:Archaeal Proteins; D018833:Chaperonins / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D006360:Heat-Shock Proteins / Q000737:chemistry*; D018832:Molecular Chaperones / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D015202:Protein Engineering; D021122:Protein Subunits / Q000737:chemistry
chemical_list: D000497:Alloys; D019843:Archaeal Proteins; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D021122:Protein Subunits; C072010:TF55 protein, Sulfolobus shibatae; C099370:palladium-cobalt alloy; C050456:nickel-palladium alloy; D003035:Cobalt; D010165:Palladium; D009532:Nickel; D018833:Chaperonins