Photoaffinity labeling of P-glycoprotein.
The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and propafenones. These studies allowed identification of protein regions, which are involved in ligand interaction.
Peer
Michael
M
Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria.
Csaszar
Edina
E
Vorlaufer
Elisabeth
E
Kopp
Stephan
S
Chiba
Peter
P
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D006801:Humans; D008024:Ligands; D019920:Photoaffinity Labels / Q000737:chemistry*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008024:Ligands; D019920:Photoaffinity Labels