Hepatitis B vaccination and central nervous system demyelination: an immunological approach.
Demyelination events or multiple sclerosis following hepatitis B virus (HBV) vaccination have been reported. We therefore compared the T-cell response to HBsAg in patients with CNS demyelination following HBV vaccination and in HBV-vaccinated healthy individuals. Our data showed no differences in terms of T-cell proliferation or cytokine production between these groups and may help to allay concerns that HBV vaccination might trigger a deleterious immune response.
Piaggio
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E
INSERM U563, Purpan University Hospital, Place Dr Baylac, Toulouse 31000, France.
Ben Younes
A
A
Desbois
S
S
Gout
O
O
Tourbah
A
A
Lyon-Caen
O
O
Liblau
R S
RS
D000328:Adult; D049109:Cell Proliferation; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology*; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism; D020278:Demyelinating Autoimmune Diseases, CNS / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000009:adverse effects* / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D014611:Vaccination / Q000009:adverse effects*
D016207:Cytokines; D017325:Hepatitis B Vaccines