Morphogenesis of the juxtaoral organ in humans.
The juxtaoral organ was studied using light microscopy in 55 human embryos and 90 fetuses at different stages of development. The juxtaoral organ arises from the epithelium at the bottom of the transverse opening of the primitive mouth during O'Rahilly stage 16 and becomes detached from the epithelium after O'Rahilly stage 18. The juxtaoral organ is innervated by the buccal nerve from O'Rahilly stage 20 onward, and its connective tissue capsule is clearly visible after week 11 of development. This study enabled us to describe three main periods of juxtaoral organ development: (1) the period of epithelial condensation and invagination, at O'Rahilly stages 16-17; (2) the period during which the juxtaoral organ becomes detached from the oral epithelium and is innervated, at O'Rahilly stages 18-23; and (3) the period during which the connective tissue capsule is formed, after week 11 of development. We also analysed the juxtaoral organ of five additional fetuses by immunohistochemistry with anti-NF-200 to verify their innervation. The results show that the juxtaoral organ may have a function in the mechanical activity of the region.
Mérida-Velasco
J R
JR
Departamento de Anatomía y Embriología Humana II, Universidad Complutense de Madrid, Spain.
Rodríguez-Vázquez
J F
JF
de la Cuadra-Blanco
C
C
Salmerón
J I
JI
Sánchez-Montesinos
I
I
Mérida-Velasco
J A
JA
D000911:Antibodies, Monoclonal; D047108:Embryonic Development / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D009024:Morphogenesis / Q000502:physiology; D009055:Mouth / Q000196:embryology*; D016900:Neurofilament Proteins / Q000276:immunology
D000911:Antibodies, Monoclonal; D016900:Neurofilament Proteins; C051774:neurofilament protein H
Anat Rec. 1999 May 1;255(1):20-33
10321990
Crit Rev Oral Biol Med. 1997;8(1):51-75
9063625
Acta Anat (Basel). 1961;45:164-76
14010144
Z Anat Entwicklungsgesch. 1953;117(3):215-36
13147305
Pediatr Dev Pathol. 1998 May-Jun;1(3):230-3
10463283
Am J Clin Pathol. 1974 Feb;61(2):275-84
4811744
Am J Surg Pathol. 1979 Apr;3(2):147-50
532846
Head Neck. 2003 May;25(5):400-5; discussion 400
12692878
Z Mikrosk Anat Forsch. 1990;104(1):170-6
2349822
Int J Oral Maxillofac Surg. 2003 Feb;32(1):101-3
12653244
Histochemistry. 1981;71(2):279-90
6787002
Oral Surg Oral Med Oral Pathol. 1978 Oct;46(4):555-8
280848
Head Neck Surg. 1981 Sep-Oct;4(1):69-71
7287449
Am J Clin Pathol. 1974 Oct;62(4):571-4
4414314
Oral Surg Oral Med Oral Pathol. 1979 Sep;48(3):231-6
289927
J Oral Pathol. 1980 Jan;9(1):16-28
6767819
Am J Surg Pathol. 1980 Jun;4(3):307-9
7396073
J Oral Med. 1984 Jul-Sep;39(3):177-9
6592300
Anat Embryol (Berl). 2002 Oct;205(5-6):417-30
12382145
Pathologe. 1993 Jul;14(4):205-9
7690134
J Pathol. 1981 Jan;133(1):17-23
7205439
Z Zellforsch Mikrosk Anat. 1968;84(1):72-86
5722596
Oral Surg Oral Med Oral Pathol. 1979 Sep;48(3):226-30
289926
G Chir. 1999 May;20(5):213-7
10380360
J Anat. 2001 Apr;198(Pt 4):423-9
11327204
Verh Anat Ges. 1965;115:479
5836825
Virchows Arch A Pathol Anat Histol. 1976 Oct 7;371(4):389-91
824807
J Pediatr Surg. 1990 Nov;25(11):1200
2273441
Z Mikrosk Anat Forsch. 1985;99(1):59-74
3993176
Arch Anat Microsc Morphol Exp. 1980;69(3):197-214
7469412
Anat Anz. 1965 Jun 22;116(4):340-4
5851813
J Clin Pathol. 2003 Oct;56(10):789-90
14514788
Z Zellforsch Mikrosk Anat. 1967;81(1):135-54
5601898
J Embryol Exp Morphol. 1971 Apr;25(2):247-61
5088022
Z Anat Entwicklungsgesch. 1974;145(2):197-218
4446674
J Anat. 1962 Jan;96:16-24
13907992