Preservation of tubal function following methotrexate treatment for ectopic pregnancy.
To evaluate methotrexate (MTX) administration as a conservative treatment for ectopic pregnancy, we reviewed the medical records of 248 cases (210 patients) of MTX treatment for tubal pregnancies at our department between December 1985 and December 2003, and compared its pregnancy prognosis with that of laparoscopic salpigotomy (59 patients). With the MTX treatment, 185 patients were successfully treated, and the subsequent pregnancy rate and ectopic pregnancy rate were 48.4 % and 18.4 %, respectively, while those rates were 49.2 % and 18.6 %, respectively, after the salpigotomy. These results suggest that MTX treatment is comparable to the more conservative operation. To clarify the (dys/) function of the ectopic implantation tubes and MTX-treated tube (s), we excluded patients who had a contra-lateral healthy tube, and extracted 40 patients as "the affected tube group", where the pregnancy-related parameters were not adversely affected. The findings suggest that MTX is not necessary to preserve tubal function.
Suzuki
Takahiro
T
Department of Obstetrics and Gynecology, Specialized Clinical Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Izumi
Shun-Ichiro
S
Awaji
Hideo
H
Matsubayashi
Hidehiko
H
Yoshikata
Kikuo
K
Kika
Goh
G
Murano
Takayo
T
Shida
Masako
M
Uchida
Noa
N
Cai
Liyi
L
Kondo
Mayu
M
Yoshitake
Tomoko
T
Makino
Tsunehisa
T
D000328:Adult; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008499:Medical Records; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use; D011247:Pregnancy; D018873:Pregnancy Rate; D011271:Pregnancy, Ectopic; D011274:Pregnancy, Tubal / Q000188:drug therapy* / Q000503:physiopathology*; D011379:Prognosis; D012189:Retrospective Studies; D012489:Salpingostomy
D008727:Methotrexate