Association of CCR5 human haplogroup E with rapid HIV type 1 disease progression.
The combination of unique single nucleotide polymorphisms in the CCR5 regulatory and in the CCR2 and CCR5 coding regions, defined nine CCR5 human haplogroups (HH): HHA-HHE, HHF*1, HHF*2, HHG*1, and HHG*2. Here we examined the distribution of CCR5 HH and their association with HIV infection and disease progression in 36 HIV-seronegative and 76 HIV-seropositive whites from North America and Spain [28 rapid progressors (RP) and 48 slow progressors (SP)]. Although analyses revealed that HHE frequencies were similar between HIV-seronegative and HIV-seropositive groups (25.0% vs. 32.2%, p > 0.05), HHE frequency in RP was significantly higher than that in SP (48.2% vs. 22.9%, p = 0.002). Survival analysis also showed that HHE heterozygous and homozygous were associated with an accelerated CD4 cell count decline to less than 200 cells/microL (adjusted RH 2.44, p = 0.045; adjusted RH = 3.12, p = 0.037, respectively). These data provide further evidence that CCR5 human haplogroups influence HIV-1 disease progression in HIV-infected persons.
Li
Ming
M
Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Song
Ruiguang
R
Masciotra
Silvina
S
Soriano
Vincent
V
Spira
Thomas J
TJ
Lal
Renu B
RB
Yang
Chunfu
C
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D000328:Adult; D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D015497:HIV-1; D006239:Haplotypes; D006801:Humans; D008297:Male; D019713:Receptors, CCR5 / Q000235:genetics*
D019713:Receptors, CCR5