[Rashes in HIV-infected patients undergoing therapy with nevirapine or efavirenz].
Efavirenz and nevirapine are frequently used drugs in antiretroviral therapy. Rashes are common side effects of these drugs. In this study, we examined the characteristics of efavirenz- and nevirapine-associated rashes. This prospective nonrandomized multicenter study included 662 HIV-infected patients (efavirenz: 325, nevirapine: 337) to determine incidence, duration, cross-reactivity, and outcome upon reexposure. Of the treated patients, 4.5% (n=30) developed rashes (nevirapine: 2.4% and efavirenz: 6.4%). In four patients treatment was not interrupted. Three patients were re-exposed to the initial drug without any side effects. Therapy with nevirapine or efavirenz does not have to be interrupted if rashes exhibit no blistering, mucosal manifestations, or systemic signs.
Hartmann
M
M
Hautklinik, Universität, Heidelberg. Martin_Hartmann@med.uni-heidelberg.de
Brust
J
J
Schuster
D
D
Mosthaf
F
F
Procaccianti
M
M
Rump
J A
JA
Klinker
H
H
Petzoldt
D
D
D000480:Alkynes; D019380:Anti-HIV Agents / Q000627:therapeutic use; D048588:Benzoxazines; D015897:Comorbidity; D003521:Cyclopropanes; D005076:Exanthema / Q000453:epidemiology*; D005260:Female; D005858:Germany / Q000453:epidemiology; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D019829:Nevirapine / Q000627:therapeutic use*; D017063:Outcome Assessment, Health Care / Q000379:methods; D010078:Oxazines / Q000627:therapeutic use*; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; D019829:Nevirapine; C098320:efavirenz
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