Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal?
The anti-double-stranded DNA (anti-dsDNA) antibody test incorporated in the 1982 revised American College of Rheumatology criteria for the classification of systemic lupus erythematosus needs updating to reflect current insights and technical achievements, including allowance for the presence of nonpathogenic anti-dsDNA antibodies. As we need to develop at least some measure of pathogenicity of anti-dsDNA antibodies, we propose that initial anti-dsDNA antibody screening is done by sensitive ELISA and supplemented by more stringent assays. Simultaneously the relevance of anti-dsDNA antibody presence needs to be restricted to clinical manifestations, thought to be caused by anti-dsDNA antibody and within an appropriate time frame.
Nossent
Hans C
HC
Department of Rheumatology, Institute of Clinical Medicine, University of Tromsø, Norway. hans.nossent@unn.no
Rekvig
Ole Petter
OP
D000974:Antibodies, Antinuclear / Q000097:blood* / Q000276:immunology; D000937:Antigen-Antibody Reactions; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000145:classification / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D016000:Cluster Analysis; D015331:Cohort Studies; D003095:Collagen Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D004247:DNA / Q000276:immunology*; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D006040:Goals; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000145:classification / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D015337:Multicenter Studies as Topic; D012015:Reference Standards; D012680:Sensitivity and Specificity; D013997:Time Factors
D000974:Antibodies, Antinuclear; D001324:Autoantigens; D004247:DNA
J Cutan Pathol. 2001 Jan;28(1):1-23
11168747
Lupus. 2004;13(11):829-37
15580978
Arthritis Rheum. 2001 Oct;44(10):2221-3
11665961
Nat Med. 2001 Nov;7(11):1189-93
11689882
Ann Rheum Dis. 2002 Dec;61(12):1099-102
12429543
Arthritis Rheum. 2003 Feb;48(2):300-12
12571837
Cell Mol Life Sci. 2003 Feb;60(2):309-20
12678496
N Engl J Med. 2003 Oct 16;349(16):1526-33
14561795
J Rheumatol. 2003 Nov;30(11):2374-81
14677180
Ann Rheum Dis. 2004 Apr;63(4):386-94
15020332
J Clin Invest. 1977 Jan;59(1):90-6
299748
Arthritis Rheum. 1982 Nov;25(11):1271-7
7138600
Arthritis Rheum. 1990 Jul;33(7):970-7
2369432
Nature. 1995 Jan 19;373(6511):252-5
7816141
Lancet. 1995 Jun 24;345(8965):1595-9
7783536
J Exp Med. 1996 Jun 1;183(6):2459-69
8676066
J Rheumatol. 1996 Nov;23(11):1842-4
8923353
Lupus. 1997;6(3):290-304
9296771
Arthritis Rheum. 1997 Sep;40(9):1725
9324032
Scand J Rheumatol. 1998;27(1):1-6
9506871
N Engl J Med. 1998 May 7;338(19):1359-68
9571257
J Immunol. 2001 Oct 1;167(7):3746-55
11564791