Activation and coreceptor expression of T lymphocytes in HIV/AIDS patients of China.
The objective of this paper was to investigate the activation and coreceptor CCR5, CXCR4 expression of T lymphocytes in HIV/AIDS patients of China, and to study their association with disease progression. Seventy-seven HIV/AIDS patients and thirteen normal controls were enrolled and three-color flow-cytometry was used to detect the activation marker HLA-DR, CD38 and the coreceptor CCR5, CXCR4 expression on T lymphocytes in whole blood samples taken from the patients and the controls. The HLA-DR, CD38 and CCR5 expression on CD4, CD8+ T cells in AIDS patients was higher than in asymptomatic HIV-1 infected patients and normal controls (p < 0.05); The activation and CCR5 expression on T lymphocytes significantly correlated with CD4+ T lymphocyte number and viral load. The activation on T lymphocytes and the expression of CCR5 on T lymphocytes in HIV/AIDS patients of China are significantly correlated with disease progression.
Shang
Hong
H
AIDS Research Center, the First Affiliated Hospital, China Medical University, Shenyang, People's Republic of China. hongshang100@hotmail.com
Zhang
Zining
Z
Jiang
Yongjun
Y
Han
Xiaoxu
X
Wang
Yanan
Y
Zhang
Min
M
Ye
Xiaohui
X
Liu
Ying
Y
Diao
Yingying
Y
Dai
Di
D
Geng
Wenqing
W
D036541:ADP-ribosyl Cyclase / Q000096:biosynthesis; D051997:ADP-ribosyl Cyclase 1; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000821:virology; D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis; D015704:CD4 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016022:Case-Control Studies; D002681:China; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008562:Membrane Glycoproteins; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D019713:Receptors, CCR5 / Q000096:biosynthesis*; D019718:Receptors, CXCR4 / Q000096:biosynthesis*; D019562:Viral Load
D015703:Antigens, CD; D015704:CD4 Antigens; D006684:HLA-DR Antigens; D008562:Membrane Glycoproteins; D012367:RNA, Viral; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1
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