title: Differential diagnosis of cholestasis following allogeneic hematopoietic stem cell transplantation in children: the contribution of serum bile acid levels in relation to other liver function tests.
abstract: Hepatic complications associated with cholestasis occur frequently in hematopoietic stem cell transplant recipients. Since bile acid seems to be a sensitive indicator of beginning cholestasis, the authors monitored total serum bile acid levels in addition to the standard liver function tests in 23 recipients of allogeneic transplants between June 1999 and September 2000. The observations suggest that bile acid is an early and sensitive marker of hepatic GvHD but not as specific as bilirubin. For cholestasis in absence of hepatic GvHD bile acid seems to be more sensitive than bilirubin. Routinely monitoring of bile acid after hematopoietic stem cell transplantation is not indicated.
authors.affiliation: University Hospitals of Essen, Department of Pediatric Hematology, Oncology and Endocrinology, Essen, Germany.
authors.forename: J L
authors.initials: JL
authors.lastname: Zakrzewski
authors.forename: A
authors.initials: A
authors.lastname: Ballauff
authors.forename: R
authors.initials: R
authors.lastname: Wieland
authors.forename: O
authors.initials: O
authors.lastname: Basu
authors.forename: B
authors.initials: B
authors.lastname: Kremens
mesh_terms: D000293:Adolescent; D001647:Bile Acids and Salts / Q000097:blood; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002779:Cholestasis / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology; D006402:Hematologic Diseases / Q000150:complications / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000209:etiology; D008111:Liver Function Tests; D008297:Male; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014184:Transplantation, Homologous
chemical_list: D001647:Bile Acids and Salts; D015415:Biomarkers; D001663:Bilirubin