Clozapine-induced type-2 diabetes mellitus: possible mechanisms and implications for clinical practice.
The atypical antipsychotic clozapine has been reported to be associated with metabolic adverse effects, including type-2 diabetes mellitus. We present two cases of diabetes mellitus associated with clozapine treatment. One case resolved entirely upon withdrawal of the drug, whereas the other did not. We discuss the molecular basis of the diabetogenic action of clozapine and recommendations for monitoring.
Tovey
Elizabeth
E
West London Mental Health NHS Trust, John Conolly Wing, Middlesex, UK.
Rampes
Hagen
H
Livingstone
Callum
C
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy; D012563:Schizophrenia, Paranoid / Q000150:complications / Q000188:drug therapy
D014150:Antipsychotic Agents; D001786:Blood Glucose; D003024:Clozapine