Oxidatively modified fibrinogen modulates blood rheological parameters.
We studied the effect of UV-oxidized fibrinogen with oxidation degrees of 10 and 20% on rheological parameters of the blood. The effect of fibrinogen with 10% oxidation degree was moderate and variable, which attests to its partial compensation with the pool of natural antioxidants. The effect of fibrinogen with 20% oxidation degree was more pronounced. It dramatically decreased deformability of erythrocytes, delayed formation of linear aggregates, accelerated formation of 3D-aggregates, enhanced the total hydrodynamic strength of aggregates, but decreased stability of the largest aggregates. It did not increase plasma viscosity, but enhanced viscosity of the blood at all shear rates. At both degrees of oxidation, suspension stability of the blood decreased, the Caisson viscosity did not change, and the difference between the values of Caisson and asymptotic viscosities markedly increased. On the whole, oxidative fibrinogen produces negative changes in blood rheological parameters, and its effect depends on the degree of oxidation.
Roitman
E V
EV
Russian Scientific Center of Surgery, Russian Academy of Medical Sciences, Moscow, Russia.
Azizova
O A
OA
Morozov
Yu A
YA
Aseichev
A V
AV
D001809:Blood Viscosity; D004903:Erythrocyte Aggregation; D005340:Fibrinogen / Q000737:chemistry* / Q000494:pharmacology; D006400:Hematocrit; D006801:Humans; D010084:Oxidation-Reduction; D012016:Reference Values; D012212:Rheology
D005340:Fibrinogen