title: [Hyperextension of fetlock joints in German Holstein and German Holstein-Limousin crossbred calves].
abstract: In two different dairy farms six calves exhibiting bilateral flexion of the fetlock joints in front or rear legs were born in 2000 to 2002. Four of the affected calves from the same farm were crossbred between German Holstein cows with red and white coat colour and a bull of the breed Limousin. The other two affected calves born on another farm were purebred German Holsteins with a black and white coat colour. The tests for BVD virus antigen and antibodies were negative in all affected calves. Three of the calves showed a lower selen and a higher glutamate dehydrogenase concentration in the analyses of blood metabolites. Two crossbred calves showed a degeneration of the liver with a progressive periportal fibrosis in a histological examination. In one calf an edema of astrocytes of the central nervous system was seen. The analysis of the pedigrees revealed for the four crossbred calves the Limousin bull as common ancestor and the mothers of the calves as relatives. For the affected purebred German Holstein calves also a sire was identified as a common ancestor. The pedigrees support inheritance through a monogenic autosomal recessive locus or more recessive gene loci with variable expressivity. However, the analysis could not clarify whether different gene loci are responsible for the congenital anomalies observed in the calves from the two farms and thus, the observed anomalies may be different genetic entities. Obvious environmental reasons were not found.
authors.affiliation: Institut für Tierzucht und Vererbungsforschung, Tierärztliche Hochschule Hannover.
authors.forename: C
authors.initials: C
authors.lastname: Bähr
authors.forename: B
authors.initials: B
authors.lastname: Baum
authors.forename: M
authors.initials: M
authors.lastname: Hewicker-Trautwein
authors.forename: H
authors.initials: H
authors.lastname: Scholz
authors.forename: O
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D002350:Carpus, Animal / Q000002:abnormalities*; D002417:Cattle / Q000002:abnormalities* / Q000097:blood / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D005808:Genes, Recessive; D008297:Male; D010375:Pedigree; D013640:Tarsal Joints / Q000002:abnormalities*