Efficacy and toxicity of zinc salts as candidate topical microbicides against vaginal herpes simplex virus type 2 infection.
Zinc salt solutions administered as topical microbicides provided significant protection against herpes simplex virus type 2 infection in a mouse vaginal challenge model. However, at the therapeutic concentration, the salt solutions caused sloughing of sheets of vaginal epithelial cells. These observations limit the utility of zinc salts as microbicides and suggest that the application of zinc solutions to mucosal surfaces has the potential to cause damage that might increase susceptibility to secondary infections at a later time.
Bourne
Nigel
N
Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd., Galveston, Texas, 77555-0436, USA. nibourne@utmb.edu
Stegall
Rachael
R
Montano
Raquel
R
Meador
Michael
M
Stanberry
Lawrence R
LR
Milligan
Gregg N
GN
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy*; D051379:Mice; D019345:Zinc Acetate / Q000627:therapeutic use; D017967:Zinc Compounds / Q000627:therapeutic use*; D019287:Zinc Sulfate / Q000627:therapeutic use
D000891:Anti-Infective Agents, Local; D017967:Zinc Compounds; D019287:Zinc Sulfate; D019345:Zinc Acetate
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