title: [The effect of particle size and amount of inhalation on the pulumonary function testsn in asthmatic children].
abstract: The effect of three nebulizers, Nisshou and LC plus, were compared by the particle size and amount of inhalation. The improvement of FEV1 at 15 minutes after the inhalation was significantly higher in LC plus than Nisshou (MMD: 7.43microm, 10.76microm). The amount of inhlation were compared between Nisshou with/without Y tube and LC plus nebulizer with/without LC valve system. Nisshou nebulizer with Y tube and LC plus nebulizer with LC valve systems were significantly better than that of LC plus nebulizer without LC valve system. Small loss of inhalation gave us better efficacy. The urinary excretion of disodium cromoglycate (DSCG) was highest in LC plus with LC valve system, Nisshou with Y tube and lowest in Nisshou without Y tube. The elecctric nebulizers produced better in MMD of 5microm and a smaller loss of inhalation. These results suggested that MMD less than 5microm and small loss from nebulizer are very important for inhalation therapy.
authors.affiliation: Department of Pediatric, Saitama Medical School.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Eiki
authors.initials: E
authors.lastname: Oosika
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nakano
authors.forename: Ieaki
authors.initials: I
authors.lastname: Kaneko
authors.forename: Toru
authors.initials: T
authors.lastname: Nakayama
authors.forename: Kyouko
authors.initials: K
authors.lastname: Mitubayashi
authors.forename: Noriko
authors.initials: N
authors.lastname: Siigai
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Okada
authors.forename: Takashi
authors.initials: T
authors.lastname: Mitubayashi
authors.forename: Nozomi
authors.initials: N
authors.lastname: Sasaki
authors.forename: Ituo
authors.initials: I
authors.lastname: Suzuki
authors.forename: Toru
authors.initials: T
authors.lastname: Akasaka
mesh_terms: D000280:Administration, Inhalation; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D009330:Nebulizers and Vaporizers; D010316:Particle Size; D012119:Respiration; D012138:Respiratory Therapy
chemical_list: D018927:Anti-Asthmatic Agents