Antimicrobial susceptibility of Shigella sonnei isolates in Japan and molecular analysis of S. sonnei isolates with reduced susceptibility to fluoroquinolones.
We performed susceptibility testing with Shigella sonnei isolates from imported and domestic cases of infection in Japan during 2001 and 2002. Some S. sonnei isolates were resistant to nalidixic acid, tetracycline, and trimethoprim-sulfamethoxazole. Most of the nalidixic acid-resistant strains showed reduced susceptibility to fluoroquinolones but did not show fluoroquinolone resistance.
Hirose
Kenji
K
Department of Bacteriology, National Institute of Infectious Diseases., 1-23-1-Toyama, Shinjuku, Tokyo 162-8640, Japan. hirosek@nih.go.jp
Terajima
Jun
J
Izumiya
Hidemasa
H
Tamura
Kazumichi
K
Arakawa
Eiji
E
Takai
Nobuko
N
Watanabe
Haruo
H
D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology; D012764:Shigella sonnei / Q000187:drug effects* / Q000235:genetics
D024841:Fluoroquinolones; D009268:Nalidixic Acid
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