Experimental bacteriophage protection against Staphylococcus aureus abscesses in a rabbit model.
In a rabbit model of wound infection caused by Staphylococcus aureus, 2 x 10(9) PFU of staphylococcal phage prevented abscess formation in rabbits when it was injected simultaneously with S. aureus (8 x 10(7) CFU) into the same subcutaneous site. Phage multiplied in the tissues. Phages might be a valuable prophylaxis against staphylococcal infection.
Wills
Quintin F
QF
Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, UK.
Kerrigan
Claire
C
Soothill
James S
JS
D000038:Abscess / Q000382:microbiology / Q000517:prevention & control* / Q000821:virology; D000818:Animals; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D011817:Rabbits; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control* / Q000821:virology; D013204:Staphylococcus Phages; D014946:Wound Infection / Q000382:microbiology / Q000517:prevention & control* / Q000821:virology
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