title: Prevalence of cranial scan abnormalities in preterm twins in relation to chorionicity and discordant birth weight.
abstract: OBJECTIVE
  The purpose of this study was to determine the incidence of ultrasonographically detected cerebral white matter lesions (WMLs) in preterm twins at birth in relation to chorionicity, discordant weight and twin-twin transfusion syndrome (TTTS).
  
  
  METHODS
  In this retrospective study, perinatal, neonatal, and cranial scan data of 85 monochorionic (MC) and 94 dichorionic (DC) twin pregnancies (341 infants) delivered between 24 and 34 weeks of gestation were collected. Data were analysed according to chorionicity, discordant birth weight (>20%), single intrauterine death and TTTS.
  
  
  RESULTS
  The cerebral WML was seen in 14% of preterm twins. Monochorionic infants had higher risks of WML than DC twin (odds ratio 7.1; 95% CI 3.28-15.8). In MC group, discordant weight (37%), TTTS (38%), single intrauterine death (67%) had higher incidence of cerebral WML than concordant weight infants (7%). Similarly, incidence of WML was higher in DC discordant compared with concordant weight infants (13% versus 2%; P < 0.05).
  
  
  CONCLUSIONS
  Monochorionic infants had a seven-fold higher incidence of cerebral WML than DC infants. Discordant birth weight, TTTS and survivor of co-twin demise are an independent risk of cerebral white matter lesion.
authors.affiliation: Academic Unit of Obstetrics and Gynaecology and Child Health, St. Mary's Hospital for Women and Children, University of Manchester, Manchester, UK.
authors.forename: Adedayo L
authors.initials: AL
authors.lastname: Adegbite
authors.forename: Shirley
authors.initials: S
authors.lastname: Castille
authors.forename: Stuart
authors.initials: S
authors.lastname: Ward
authors.forename: Rekha
authors.initials: R
authors.lastname: Bajoria
mesh_terms: D001724:Birth Weight; D001927:Brain Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D002823:Chorion; D004200:Diseases in Twins / Q000150:complications; D005260:Female; D005317:Fetal Growth Retardation / Q000150:complications* / Q000000981:diagnostic imaging; D005330:Fetofetal Transfusion / Q000150:complications; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000150:complications*; D015995:Prevalence; D012189:Retrospective Studies; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic; D016216:Ultrasonography, Prenatal