A new lipase in regulating lipid mobilization: hormone-sensitive lipase is not alone.
Three papers recently appeared simultaneously that identify a new triacylglycerol lipase. Zimmerman et al. identified this lipase as adipocyte triacylglycerol lipase (ATGL). Jenkins et al. identified it as the zeta-isoform of a calcium-independent phospholipase A(2) (iPLA(2)), whereas Villena et al. found this enzyme and called it desnutrin. Interestingly, if, as implied, this lipase works in concert with hormone-sensitive lipase, then our concept of regulated fatty acid mobilization from triacylglycerols will have to be revised.
Raben
Daniel M
DM
Department of Biological Chemistry, The Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA. draben@jhmi.edu
Baldassare
Joseph J
JJ
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002265:Carboxylic Ester Hydrolases / Q000502:physiology*; D054522:Group VI Phospholipases A2; D006801:Humans; D007527:Isoenzymes / Q000502:physiology; D008049:Lipase / Q000502:physiology*; D050356:Lipid Metabolism; D051379:Mice; D010741:Phospholipases A / Q000502:physiology*; D002787:Sterol Esterase / Q000502:physiology*; D009626:Terminology as Topic; D000217:Acyltransferases
D002265:Carboxylic Ester Hydrolases; D054522:Group VI Phospholipases A2; D007527:Isoenzymes; D008049:Lipase; D010741:Phospholipases A; D002787:Sterol Esterase; C494445:PNPLA2 protein, mouse; D000217:Acyltransferases; C516475:PLA2G6 protein, human; C516476:Pla2g6 protein, mouse