title: Cytotoxic flavonol glycosides from Triplaris cumingiana.
abstract: Three new compounds, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl-4,6-bis-O-beta-D-(3,4,5-trihydroxybenzoyl)glucopyranoside (1), 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl-5-O-alpha-L-(3,4,5-trihydroxybenzoyl)arabinofuranoside (2), and 2-hydroxy-4-O-alpha-L-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenylarabinofuranoside (3), were isolated from the young leaves of Triplaris cumingiana, together with two known compounds, quercetin 3-O-alpha-L-(5"-O-galloyl)arabinofuranoside (4) and quercetin 3-O-beta-D-(6"-O-galloyl)glucopyranoside (5). The structures of 1-3 were established by spectroscopic methods. Compounds 1-5 were evaluated for their cytotoxic activities against the MCF-7, H-460, and SF-268 human cancer cell lines.
authors.affiliation: Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panamá, República de Panamá.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Hussein
authors.forename: Icela
authors.initials: I
authors.lastname: Barberena
authors.forename: Mireya
authors.initials: M
authors.lastname: Correa
authors.forename: Phyllis D
authors.initials: PD
authors.lastname: Coley
authors.forename: Pablo N
authors.initials: PN
authors.lastname: Solis
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Gupta
mesh_terms: D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010176:Panama; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D044948:Flavonols; D006027:Glycosides