Bone loss preventing effect of Sophorae Fructus on ovariectomized rats.
The preventive effects of Sophorae Fructus extracts (I: hot water extract and II: combination product using I) on bone loss in ovariectomized (OVX) rats were investigated. Sophorae Fructus extracts were orally administrated to OVX rats for 9 weeks. Ovariectomy caused the increase of body weight and deoxypyridinoline (Dpd: bone resorption marker) and decrease of calcium (Ca: bone formation marker) level in serum. Dpd level were significantly decreased and Ca levels were elevated at 9 weeks in Sophorae Fructus extracts administered groups after ovariectomy at a dose of 0.556 g/kg/day compared with control group. In administered groups, trabecular bone area (TBA) in the tibia and lumbar were also increased compared with control group in histomorphological analysis. The preventive or treatment effects of Sophorae Fructus extracts on bone loss in OVX rats appears to be due to suppression of bone turnover.
Shim
Jae Geul
JG
College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
Yeom
Seung Hwan
SH
Kim
Hyun Jung
HJ
Choi
Young Wook
YW
Lee
Do Ik
DI
Song
Kye Yong
KY
Kwon
Suk Hyung
SH
Lee
Min Won
MW
D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D001862:Bone Resorption / Q000097:blood / Q000517:prevention & control*; D002118:Calcium / Q000097:blood; D005260:Female; D005638:Fruit; D010052:Ovariectomy; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D029909:Sophora; D013977:Tibia / Q000187:drug effects / Q000378:metabolism
D010936:Plant Extracts; D002118:Calcium