Enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by thalidomide and its metabolites.
Thalidomide (Thal: 1) and its two metabolites, 5-hydroxythalidomide (5-HT: 2) and N-hydroxythalidomide (N-HT: 3), showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation. 5-HT and N-HT showed tubulin polymerization-inhibiting activity, but thalidomide did not.
Noguchi
Tomomi
T
Institute of Molecular & Cellular Biosciences, The University of Tokyo, Yayoi, Tokyo, Japan.
Shinji
Chihiro
C
Kobayashi
Hisayoshi
H
Makishima
Makoto
M
Miyachi
Hiroyuki
H
Hashimoto
Yuichi
Y
D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology; D004357:Drug Synergism; D018922:HL-60 Cells; D006801:Humans; D013792:Thalidomide / Q000378:metabolism* / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology*
D013792:Thalidomide; D014212:Tretinoin