title: New naphthylcombretastatins. Modifications on the ethylene bridge.
abstract: Compounds with three aromatic systems, carrying a 2-naphthalene and a 3,4,5-trimethoxyphenyl moieties bonded to five-membered, six-membered or fused heterocycles display potent cytotoxic effect and inhibition of tubulin polymerization, in agreement with their structural similarity to combretastatins and their heterocyclic analogues.
authors.affiliation: Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
authors.forename: Ana B
authors.initials: AB
authors.lastname: Sánchez Maya
authors.forename: Concepción
authors.initials: C
authors.lastname: Pérez-Melero
authors.forename: Nélida
authors.initials: N
authors.lastname: Salvador
authors.forename: Rafael
authors.initials: R
authors.lastname: Peláez
authors.forename: Esther
authors.initials: E
authors.lastname: Caballero
authors.forename: Manuel
authors.initials: M
authors.lastname: Medarde
mesh_terms: D000818:Animals; D001632:Bibenzyls / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002417:Cattle; D005030:Ethylenes / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000378:metabolism
chemical_list: D001632:Bibenzyls; D005030:Ethylenes; D009281:Naphthalenes; D013267:Stilbenes; D014404:Tubulin; C031721:naphthalene; C040105:combretastatin; C036216:ethylene