title: Pneumococcal infections in Trinidad: patterns of antimicrobial susceptibility: 1994-2002.
abstract: Antimicrobial susceptibilities of 156 Streptococcus pneumoniae strains isolated from 1994 through 2002 were studied. Of this total, 38.7, 26.3, 16.7, 8.9, and 9.6% were recovered from patients with bacteremia, pneumonia, otitis media, sinusitis, and meningitis, respectively. All S. pneumoniae strains were fully susceptible to amoxicillin-clavulanic acid and ampicillin, with 9.0 and 2.6% being resistant to penicillin and ceftriaxone, respectively. The ratios of resistant strains to tetracycline, co-trimoxazole, and chloramphenicol were 73.7, 69.3, and 63.5%, respectively. Approximately 90% of strains remain sensitive to erythromycin. A high prevalence of resistance to the penicillins and cephalosporins does not exist in Trinidad, although a trend toward such a pattern appears to be developing. The most frequent serotype was 14 (38.0%), followed by 6B (20%), 23F (10.3%), and 4 (6.4%), and all were recovered from children. The other serotypes accounted for <6% of the total isolates. All penicillin- and ceftriaxone-resistant strains belonged to serotype 14 (MIC > or = 2 microg/ml and > or = 4 microg/ml), respectively. Identifiable risk factors for resistant isolates included the prevalence of otitis media and sinusitis among children treated inadequately with oral cephalosporins; the ease of obtaining antibiotics without a prescription at many pharmacies; and the indiscriminate prescribing of antibiotics by general practitioners.
authors.affiliation: Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, Champ Fleurs, Trinidad and Tobago, West Indies. drfao4301@yahoo.com
authors.forename: Fitzroy A
authors.initials: FA
authors.lastname: Orrett
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D014300:Trinidad and Tobago / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents