[Inhibitory proteins against axon regeneration in the central nervous system].
Growth inhibition in the central nervous system (CNS) is a majar barrier to axon regeneration. To date, three inhibitory proteins of oligodendrocytes/myelin have been identified: myelin associated glycoprotein ( MAG) , Nogo-A and oligodendrocyte-myelin glycoprotein (OMgp). Recently, findings indicate that three distinct myelin components inhibit axon growth by binding a common receptor, the Nogo 66 receptor (NgR). These novel findings lead to further understanding of the barriers to axon regeneration after injury in the CNS and provide new avenues to explore the new theraphy strategy for the CNS injury.
Hu
Jian-Guo
JG
Department of Neurobiology, Shanghai Second Medical University, Shanghai.
Lu
Pei-Hua
PH
Xu
Xiao-min
XM
D001369:Axons / Q000378:metabolism / Q000502:physiology*; D002490:Central Nervous System / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D058851:GPI-Linked Proteins; D009185:Myelin Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D018992:Myelin-Associated Glycoprotein / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D009416:Nerve Regeneration / Q000502:physiology; D016501:Neurites / Q000378:metabolism / Q000502:physiology; D000070798:Nogo Proteins; D000070816:Nogo Receptor 1; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D058851:GPI-Linked Proteins; C571326:MOG protein, human; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D000070798:Nogo Proteins; D000070816:Nogo Receptor 1; C560528:OMG protein, human; C000603199:RTN4 protein, human; C486580:RTN4R protein, human; D011956:Receptors, Cell Surface