title: Two cases of antinuclear antibody negative lupus showing increased proportion of B cells lacking RP105.
abstract: B cells lacking RP105 molecule, a member of the Toll-like receptor family, were increased in the peripheral blood of 2 patients with antinuclear antibody (ANA) negative systemic lupus erythematosus (SLE). The increased proportion of RP105-lacking B cells was associated with disease activity in patients with ANA-negative SLE. When there are no significant serological markers for SLE, analysis of expression of RP105 may be helpful in evaluation of activity in ANA-negative SLE. We describe a new approach, using phenotyping of B cells, to evaluate activity of ANA-negative SLE.
authors.affiliation: Division of Rheumatology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan. koarad@post.saga-med.ac.jp
authors.forename: Syuichi
authors.initials: S
authors.lastname: Koarada
authors.forename: Masaru
authors.initials: M
authors.lastname: Ide
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Haruta
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Tada
authors.forename: Osamu
authors.initials: O
authors.lastname: Ushiyama
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Morito
authors.forename: Akihide
authors.initials: A
authors.lastname: Ohta
authors.forename: Kohei
authors.initials: K
authors.lastname: Nagasawa
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood / Q000276:immunology*; D015703:Antigens, CD / Q000097:blood / Q000276:immunology*; D001402:B-Lymphocytes / Q000378:metabolism*; D015415:Biomarkers; D001921:Brain / Q000276:immunology / Q000473:pathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D008297:Male
chemical_list: D000974:Antibodies, Antinuclear; D015703:Antigens, CD; D015415:Biomarkers; C092722:CD180 protein, human