Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia.
OBJECTIVE
To report on a trial of adding amisulpride to clozapine.


METHODS
Description of six cases.


RESULTS
Six patients who had been on clozapine were commenced on amisulpride. All patients had had unwanted effects with clozapine, particularly sedation, hypersalivation, or weight gain. Five patients reported a high level of satisfaction with the regimen, having a reduction in the level of sedation and improvement in levels of motivation and energy, without recurrence of positive symptoms.


CONCLUSIONS
The combined use of amisulpride and clozapine would appear to be an appropriate and beneficial treatment.
Cook
Brian
B
Bundaberg Integrated Mental Health Service, Bundaberg, Queensland 4670, Australia.
Hoogenboom
Gerry
G
D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D003024:Clozapine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013469:Sulpiride / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride; D003024:Clozapine