[Screening for the G1528C mutation in long chain fatty acid oxidation enzyme in Han nationality in Beijing population].
OBJECTIVE
To explore the carrier rate of G1528C mutation in alpha-subunit gene of MTP in Chinese newborns.


METHODS
1 200 cases of cord blood samples were taken in pregnant women with Han nationality in Chinese. PCR-RFLP analysis was conducted for detection of G1528C mutation.


RESULTS
No. G1528C mutations in LCHAD gene were found in these study subjects.


CONCLUSIONS
G1528C is probably not the common prevalent mutation in MTP gene in Chinese. Different prevalent mutation between Chinese and Western white people needs further study.
Zhu
Jin-ming
JM
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083, China.
Yang
Zi
Z
Yu
Mei
M
Wang
Rong
R
Ye
Rong-hua
RH
Yang
Hui-xia
HX
Zhai
Gui-rong
GR
Wang
Qi
Q
D002681:China / Q000208:ethnology; D005260:Female; D005820:Genetic Testing; D006801:Humans; D007231:Infant, Newborn; D008052:Lipid Metabolism, Inborn Errors / Q000235:genetics; D008297:Male; D063991:Mitochondrial Trifunctional Protein; D009097:Multienzyme Complexes / Q000235:genetics*; D010084:Oxidation-Reduction; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D009097:Multienzyme Complexes; D063991:Mitochondrial Trifunctional Protein