Jumping translocation of 1q in a BCR/ABL-positive acute lymphoblastic leukemia.
Jumping translocations (JT) are rare chromosomal abnormalities in which an identical copy of a chromosomal region (donor) is translocated to a different chromosome (acceptor). Chromosome 1 is often involved as donor chromosome. JTs of the long arm of chromosome 1 (1q) or parts of it are associated with a poor outcome. We report on a 72-year-old male patient with a BCR/ABL1 rearrangement positive acute lymphoblastic leukemia (common ALL, or c-ALL; FAB L2 morphology) and with additional structural and numeric aberrations. Four aberrant clones were observed after conventional cytogenetic analysis. Three of the four clones showed a JT with 1q as donor and 3q, 8q, and 22q as acceptors. To the best of our knowledge, neither JT between 1q and chromosome 3 nor JT between 1q and chromosome 22 have been described in c-ALL. This report emphasizes the frequent involvement of 1q in JT and the association with a poor prognosis.
Pelz
Antje-Friederike
AF
Institute of Human Genetics, Otto-von-Guericke University of Magdeburg, Leipziger Strasse 44, H.26, D-39120 Magdeburg, Germany. Antje-Friederike.Pelz@medizin.uni-magdeburg.de
Müller
Gerd
G
Wieacker
Peter
P
D000368:Aged; D002878:Chromosomes, Human, Pair 1; D002892:Chromosomes, Human, Pair 22; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism*; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic
D016044:Fusion Proteins, bcr-abl