Maternal caffeine intake impairs MK-801-induced hyperlocomotion in young rats.
Here we have investigated the effects of maternal caffeine intake (1 g/l) on MK-801-induced hyperlocomotion in rat pups. Animals submitted to caffeine treatment during the gestational and lactational period were separated in two groups: caffeine-treated group (up to 21 days old) and washout group (caffeine treatment up to 7 days old). MK-801 (0.25 mg/kg, i.p.) promoted hyperlocomotion in control rats, but this stimulatory effect was significantly decreased in caffeine-treated and washout groups. The permanent effect after caffeine withdrawal suggests durable or adaptive changes during neurodevelopment, mainly on adenosine receptors or neurotransmitter systems modulated by adenosine, such as the glutamatergic system.
da Silva
Rosane Souza
RS
Laboratório de Pesquisa Bioquímica, Departamento de Ciências Fisiológicas, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619-900, Porto Alegre, RS, Brazil. rosanebio@yahoo.com.br
Hoffman
Anselmo
A
de Souza
Diogo Onofre
DO
Lara
Diogo R
DR
Bonan
Carla Denise
CD
D000818:Animals; D000831:Animals, Newborn; D002110:Caffeine / Q000008:administration & dosage* / Q000633:toxicity; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000633:toxicity; D016291:Dizocilpine Maleate / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000697:Central Nervous System Stimulants; D018696:Neuroprotective Agents; D002110:Caffeine; D016291:Dizocilpine Maleate