title: Integrons and transposons on the Salmonella enterica serovar typhimurium virulence plasmid.
abstract: A virulence plasmid was identified in a multidrug-resistant Salmonella enterica serotype Typhimurium strain carrying the spvC, rck, and pefA virulence genes and two class 1 integrons linked to the Tn21 and Tn1696 transposons. A novel trimethoprim resistance gene, designated dfrA23, was also identified within the integron region. The association of multidrug resistance and virulence determinants represents an interesting example of virulence plasmid evolution.
authors.affiliation: Department of Infectious, Parasitic, and Immuno-mediated Disease, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Villa
authors.forename: Alessandra
authors.initials: A
authors.lastname: Carattoli
mesh_terms: D000595:Amino Acid Sequence; D004251:DNA Transposable Elements; D024901:Drug Resistance, Multiple, Bacterial; D032023:Integrons; D008969:Molecular Sequence Data; D010957:Plasmids; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D004251:DNA Transposable Elements
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