VDUP1 is required for the development of natural killer cells.
Vitamin D3 upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)2D3 in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1-/- mice). VDUP1-/- mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1-/- mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1-/- mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo.
Lee
Kee Nyung
KN
Laboratory of Immunology, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon 305-333, Republic of Korea.
Kang
Hyung-Sik
HS
Jeon
Jun-Ho
JH
Kim
Eun-Mi
EM
Yoon
Suk-Ran
SR
Song
Hyunkeun
H
Lyu
Chil-Youl
CY
Piao
Zheng-Hao
ZH
Kim
Sun-Uk
SU
Han
Ying-Hao
YH
Song
Su-Sung
SS
Lee
Young-Ho
YH
Song
Kyu-Sang
KS
Kim
Yong-Man
YM
Yu
Dae-Yeul
DY
Choi
Inpyo
I
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D002454:Cell Differentiation; D002460:Cell Line; D017353:Gene Deletion; D005786:Gene Expression Regulation; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism / Q000473:pathology; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D013879:Thioredoxins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
D002352:Carrier Proteins; D015375:Receptors, Interleukin-2; C445672:Txnip protein, mouse; D013879:Thioredoxins