title: Antitubercular constituents from the roots of Engelhardia roxburghiana.
abstract: Three new compounds, engelhardione, (-)-5-hydroxy-4-methoxy-1-tetralone, and 3-methoxycarbonyl-1,5-dihydroxyanthraquinone, together with twelve known compounds have been isolated from the roots of Engelhardia roxburghiana. The structures of these new compounds were determined through spectral analyses. Engelhardione, 3-methoxyjuglone, and (-)-4-hydroxy-1-tetralone showed antitubercular activities with MIC values=3.125, 3.125, and 6.25 microg/mL against Mycobacterium tuberculosis 90-221,387, respectively, and with MIC values=0.2, 0.2, and 4.0 microg/mL against M. tuberculosis H37Rv, individually.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Lin
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Ian-Lih
authors.initials: IL
authors.lastname: Tsai
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D029525:Juglandaceae; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots
chemical_list: D000995:Antitubercular Agents; D010936:Plant Extracts