title: Successful treatment of chemo-refractory pulmonary metastases of renal pelvic cancer by second-line chemotherapy including gemcitabine followed by salvage surgery.
abstract: A 51-year-old woman developed multiple pulmonary metastases after receiving nephroureterectomy and two cycles of adjuvant chemotherapy for the treatment of renal pelvic transitional cell carcinoma. All metastases disappeared after four cycles of methotrexate, vinblastine, doxorubicin and cisplatin (M-VAC) chemotherapy followed by radiotherapy; however, 8 months later two pulmonary metastases recurred. The patient was entered into a phase I study of combination chemotherapy with gemcitabine, etoposide and cisplatin, designed for chemorefractory urothelial cancer. The lung masses showed significant reduction after two cycles of this chemotherapy; following salvage surgery, the patient has been well with no evidence of recurrence for more than 3 years.
authors.affiliation: Department of Urology, Cancer Institute Hospital, Tokyo, Japan. tatokoro@yahoo.co.jp
authors.forename: Manabu
authors.initials: M
authors.lastname: Tadokoro
authors.forename: Junji
authors.initials: J
authors.lastname: Yonese
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Okubo
authors.forename: Eiki
authors.initials: E
authors.lastname: Hanada
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Satoh
authors.forename: Ken
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Iwao
authors.initials: I
authors.lastname: Fukui
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D019008:Drug Resistance, Neoplasm; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy; D007682:Kidney Pelvis / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D008875:Middle Aged; D016879:Salvage Therapy; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D005047:Etoposide; D002945:Cisplatin; D000093542:Gemcitabine