title: Applications of the amino-Cope rearrangement: synthesis of tetrahydropyran, delta-lactone and piperidine targets.
abstract: We report a novel approach to some chiral tetrahydropyran and delta-lactone targets that utilizes the asymmetric amino-Cope rearrangement as a key synthetic step. Products of amino-Cope rearrangement chemistry have also been applied to access piperidine targets, further demonstrating the potential of the methodology.
authors.affiliation: Department of Chemistry, Loughborough University, Loughborough, Leicestershire, UK LE11 3TU. s.m.allin@lboro.ac.uk
authors.forename: Steven M
authors.initials: SM
authors.lastname: Allin
authors.forename: Munira
authors.initials: M
authors.lastname: Essat
authors.forename: Catarina Horro
authors.initials: CH
authors.lastname: Pita
authors.forename: Robert D
authors.initials: RD
authors.lastname: Baird
authors.forename: Vickie
authors.initials: V
authors.lastname: McKee
authors.forename: Mark
authors.initials: M
authors.lastname: Elsegood
authors.forename: Mark
authors.initials: M
authors.lastname: Edgar
authors.forename: David M
authors.initials: DM
authors.lastname: Andrews
authors.forename: Pritom
authors.initials: P
authors.lastname: Shah
authors.forename: Ian
authors.initials: I
authors.lastname: Aspinall
mesh_terms: D018360:Crystallography, X-Ray; D003500:Cyclization; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007783:Lactones; D010880:Piperidines; D011714:Pyrans