Cytogenetic abnormalities related to histopathologic grade of astrocytic tumors.
Cytogenetic analysis was performed on 7 low-grade astrocytomas, 10 anaplastic astrocytomas, and 14 glioblastomas. Abnormal chromosome numbers were noted in all cases of high-grade astrocytomas but were rarely noted in low-grade astrocytomas (28%). The most consistent changes in high-grade astrocytomas were complete loss of chromosome 10 (61%), gain of chromosome 7 (56%), and loss of chromosome 17 (28%). Certain structural abnormalities, such as marker chromosomes and double minutes (33%), and the deletion and translocation of chromosomes 1 (33%) and 17 (17%), were also noted. These results indicate that changes in the number and/or structure of chromosomes with related inactivation of tumor suppressor gene or oncogene activation might play a critical role in the formation and anaplastic progression of astrocytic tumors.
Lee
M C
MC
Department of Pathology, Chonnam National University Medical School and Hospital, 8 Hakdong, Dongku, Kwangju 501-190, Korea. mclee@orion.chonnam.ac.kr
Park
H S
HS
Kim
S H
SH
Jung
S
S
Kim
J H
JH
Kang
S S
SS
Lee
J H
JH
D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000235:genetics* / Q000473:pathology*; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology*; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged