Hyaluronidase versus Foley catheter for cervical ripening in high-risk term and post term pregnancies.
OBJECTIVE
To evaluate the effectiveness and safety of Foley catheter and hyaluronidase for cervical ripening.


METHODS
Randomized controlled trial where 140 pregnant women, with gestational age > or = 37 weeks, indication for labor induction and an unripe cervix, were enrolled, allocated in two groups according to the method of cervical ripening before labor induction. Statistical analysis used Student's t-test, Mann-Whitney, Chi-square test, survival analysis, risk ratios and number needed to treat.


RESULTS
Time of induction, dose of oxytocin and mode of delivery had better results in the Foley catheter group. Comfort with the method was higher in the hyaluronidase group.


CONCLUSIONS
Both methods were effective and safe for cervical ripening. The Foley catheter group experienced a shorter period of induction, required a lower dose of oxytocin and had higher vaginal delivery rates, while the women who used hyaluronidase declared greater comfort with the method.
Surita
F G C
FG
Department of Obstetrics and Gynecology, University of Campinas, Campinas, SP, Brazil.
Cecatti
J G
JG
Parpinelli
M A
MA
Krupa
F
F
Pinto E Silva
J L
JL
D002404:Catheterization; D020070:Cervical Ripening / Q000187:drug effects; D002585:Cesarean Section; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D007751:Labor, Induced; D017060:Patient Satisfaction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011273:Pregnancy, Prolonged; D011446:Prospective Studies
D006821:Hyaluronoglucosaminidase