title: The architecture of the tau haplotype block in different ethnicities.
abstract: We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of approximately 2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Building 35, Room 1A1008, MSC 3707, Bethesda, MD 20892, USA. fungp@mail.nih.gov
authors.forename: Hon Chung
authors.initials: HC
authors.lastname: Fung
authors.forename: Jessica
authors.initials: J
authors.lastname: Evans
authors.forename: Whitney
authors.initials: W
authors.lastname: Evans
authors.forename: Jaime
authors.initials: J
authors.lastname: Duckworth
authors.forename: Alan
authors.initials: A
authors.lastname: Pittman
authors.forename: Rohan
authors.initials: R
authors.lastname: de Silva
authors.forename: Amanda
authors.initials: A
authors.lastname: Myers
authors.forename: John
authors.initials: J
authors.lastname: Hardy
mesh_terms: D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D019636:Neurodegenerative Diseases / Q000208:ethnology / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins