title: Effectiveness and safety of the thrombolytic therapy for acute pulmonary thromboembolism: results of a multicenter registry in the Japanese Society of Pulmonary Embolism Research.
abstract: OBJECTIVE
  To assess the effectiveness and safety of thrombolytic treatment for acute pulmonary thromboembolism (APTE), especially in the hemodynamically stable patients with right ventricular afterload stress.
  
  
  RESULTS
  In a total of 221 patients with APTE, the association between thrombolytic treatment and the clinical outcomes were investigated. Thrombolysis was given to 121 patients (Thrombolytic Group), and the remaining 100 patients were treated with anticoagulation alone (Anticoagulation Group). In both patients with prolonged shock and patients who were hemodynamically stable without right ventricular afterload stress, the rate of death and recurrence of APTE in Anticoagulation Group were similar to those in Thrombolytic Group. In patients with right ventricular afterload stress, better outcomes were observed in Thrombolytic Group than in Anticoagulation Group, although the difference did not reach statistical significance. There was no significant difference in the rate of major bleeding episode between these two groups.
  
  
  CONCLUSIONS
  Our results suggested that performing thrombolytic treatment in APTE patients with right ventricular afterload stress should be considered even in Japan.
authors.affiliation: The First Department of Internal Medicine, Mie University, Edobashi 2-147, Tsu 514-8507, Japan. mashio@clin.mie-u.ac.jp
authors.forename: Mashio
authors.initials: M
authors.lastname: Nakamura
authors.forename: Norifumi
authors.initials: N
authors.lastname: Nakanishi
authors.forename: Norikazu
authors.initials: N
authors.lastname: Yamada
authors.forename: Masahito
authors.initials: M
authors.lastname: Sakuma
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Miyahara
authors.forename: Osamu
authors.initials: O
authors.lastname: Okada
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tanabe
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kuriyama
authors.forename: Takeyoshi
authors.initials: T
authors.lastname: Kunieda
authors.forename: Kunio
authors.initials: K
authors.lastname: Shirato
authors.forename: Tsuneaki
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000208:Acute Disease; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000188:drug therapy*; D012042:Registries; D012189:Retrospective Studies; D015912:Thrombolytic Therapy