Lack of association between hepatitis B virus infection and polymorphism of mannose-binding lectin gene in Korean population.
Mannose-binding lectin (MBL) plays an important role in immune defense. This study was undertaken to investigate the association between hepatitis B virus infection and polymorphisms of MBL gene. We assessed the single nucleotide polymorphism at codon 54 in exon 1 of MBL in patients with hepatitis B virus infection and HBsAg negative controls in Korean population. A total of 498 enrolled subjects was classified into four groups. Group 1; Clearance, Group 2; Inactive healthy carrier, Group 3; Chronic hepatitis, Group 4; Liver cirrhosis. MBL gene polymorphisms at codon 54 led to three genotypes (G/G, G/A, A/A). When we divided subjects into clearance group (group 1) and persistence group (group 2-4), G/G genotype and A-allele carrier were observed in 55.6% and 44.4% in clearance group, 64.8% and 35.2% in persistence group (p=0.081), respectively. When hepatitis B virus persistent cases were divided into inactive healthy carrier (group 2) and disease progression group (group 3 and 4), MBL gene polymorphisms at codon 54 were not related to disease progression (p=0.166). MBL gene polymorphism at codon 54 was not associated with the clearance of hepatitis B virus infection nor progression of disease in chronic hepatitis B virus infection.
Cheong
Jae Youn
JY
Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea.
Cho
Sung Won
SW
Lim
Sun Kyo
SK
Shin
Do Hyun
DH
Yoon
Seung Kew
SK
Lee
Jong Eun
JE
Hahm
Ki Baik
KB
Kim
Jin Hong
JH
D000328:Adult; D000483:Alleles; D003062:Codon; D018450:Disease Progression; D005260:Female; D005355:Fibrosis; D005838:Genotype; D006505:Hepatitis; D006509:Hepatitis B / Q000235:genetics* / Q000378:metabolism*; D006515:Hepatitis B virus / Q000378:metabolism*; D006579:Heterozygote; D006801:Humans; D007723:Korea; D037102:Lectins; D008297:Male; D037601:Mannose-Binding Lectin / Q000737:chemistry* / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
D003062:Codon; D037102:Lectins; D037601:Mannose-Binding Lectin
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