title: Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice.
abstract: Nasal carriage is a major risk factor for Staphylococcus aureus infection, especially for methicillin-resistant strains (MRSA). Using a mouse model of nasal carriage, we have compared several S. aureus strains and demonstrated increased colonization levels by MRSA in cystic fibrosis transmembrane conductance regulator-deficient mice and Toll-like receptor 2 (TLR2)-deficient mice but not TLR4-deficient mice.
authors.affiliation: Unité des Agents Antibactériens, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: González-Zorn
authors.forename: Jose P M
authors.initials: JP
authors.lastname: Senna
authors.forename: Laurence
authors.initials: L
authors.lastname: Fiette
authors.forename: Spencer
authors.initials: S
authors.lastname: Shorte
authors.forename: Aurélie
authors.initials: A
authors.lastname: Testard
authors.forename: Michel
authors.initials: M
authors.lastname: Chignard
authors.forename: Patrice
authors.initials: P
authors.lastname: Courvalin
authors.forename: Catherine
authors.initials: C
authors.lastname: Grillot-Courvalin
mesh_terms: D000818:Animals; D002353:Carrier State / Q000382:microbiology*; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D016106:Methicillin Resistance; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018181:Mice, Inbred CFTR; D018345:Mice, Knockout; D009666:Nose / Q000382:microbiology*; D011956:Receptors, Cell Surface / Q000235:genetics; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4
chemical_list: D011956:Receptors, Cell Surface; C493486:Tlr2 protein, mouse; C493487:Tlr4 protein, mouse; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4
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