Genetic vaccination against murine cysticercosis by using a plasmid vector carrying Taenia solium paramyosin.
A plasmid vector carrying the immunoprotective amino-terminal fragment of Taenia solium paramyosin (VW2-1) was designed for genetic vaccination studies. Mice that were genetically immunized with VW2-1 and challenged by intraperitoneal inoculation of Taenia crassiceps cysticerci showed 43 to 48% reductions in the parasite burden, values which were similar to values obtained previously when the recombinant protein was used.
Solís
Carlos F
CF
Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, Ciudad Universitaria, C.P. 04510, México D.F., Mexico.
Ostoa-Saloma
Pedro
P
Lugo-Martínez
Verónica H
VH
Johnston
Stephen Albert
SA
Laclette
Juan Pedro
JP
D000818:Animals; D003551:Cysticercosis / Q000469:parasitology / Q000517:prevention & control*; D005260:Female; D005822:Genetic Vectors; D051379:Mice; D008807:Mice, Inbred BALB C; D010957:Plasmids; D041201:Taenia solium / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D014335:Tropomyosin / Q000235:genetics / Q000276:immunology*; D014611:Vaccination; D019444:Vaccines, DNA / Q000008:administration & dosage*
D014335:Tropomyosin; D019444:Vaccines, DNA
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