title: Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice.
abstract: Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial working memory (SWM) tasks, although their spatial reference memory remains normal. Here we show that forebrain-localized expression of GFP-tagged GluR-A subunits in GluR-A-deficient mice rescues SWM, paralleling its rescue of CA3-CA1 LTP. This provides powerful new evidence linking hippocampal GluR-A-dependent synaptic plasticity to rapid, flexible memory processing.
authors.affiliation: Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK.
authors.forename: W B
authors.initials: WB
authors.lastname: Schmitt
authors.forename: R
authors.initials: R
authors.lastname: Sprengel
authors.forename: V
authors.initials: V
authors.lastname: Mack
authors.forename: R W
authors.initials: RW
authors.lastname: Draft
authors.forename: P H
authors.initials: PH
authors.lastname: Seeburg
authors.forename: R M J
authors.initials: RM
authors.lastname: Deacon
authors.forename: J N P
authors.initials: JN
authors.lastname: Rawlins
authors.forename: D M
authors.initials: DM
authors.lastname: Bannerman
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002452:Cell Count / Q000379:methods; D004195:Disease Models, Animal; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000503:physiopathology; D007150:Immunohistochemistry / Q000379:methods; D066298:In Vitro Techniques; D007211:Indoles; D017774:Long-Term Potentiation / Q000235:genetics; D008569:Memory Disorders / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D008570:Memory, Short-Term / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D017966:Pyramidal Cells / Q000502:physiology; D018091:Receptors, AMPA / Q000172:deficiency* / Q000235:genetics; D013028:Space Perception / Q000502:physiology*; D014161:Transduction, Genetic
chemical_list: D049452:Green Fluorescent Proteins; D007211:Indoles; D018091:Receptors, AMPA; C007293:DAPI