title: A novel bis-furan derivative, two new natural furan derivatives from Rehmannia glutinosa and their bioactivity.
abstract: A novel bis-furan derivative and two new natural furan derivatives were isolated from the CHCl3 extracts of the dried roots of Rehmannia glutinosa (Gaerth) Lilosch. Their structures were identified as 1,5-bis(5-methoxymethyl)furan-2-yl-penta-1,4-dien-3-one 1, (E)-4-(5-(methoxymethyl)furan-2-yl)but-3-en-2-one 2 and (E)-4-(5-(hydroxymethyl)furan-2-yl)but-3-en-2-one 3 on the basis of spectral data. Moreover, biological assay showed that 1 (10 microg/mL) and 3 (10 microg/mL) can promote immune activity, 2 (100 microg/mL) and 3 (100 microg/mL) inhibit immune activity and 1 can inhibit blood platelet aggregation.
authors.affiliation: State Key Laboratory of New Drug Research, Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China. sinodlsia@yahoo.com
authors.forename: Yun-Sen
authors.initials: YS
authors.lastname: Li
authors.forename: Zi-Jun
authors.initials: ZJ
authors.lastname: Chen
authors.forename: Da-Yuan
authors.initials: DY
authors.lastname: Zhu
mesh_terms: D000818:Animals; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007107:Immune System / Q000187:drug effects; D051379:Mice; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D032267:Rehmannia / Q000737:chemistry*
chemical_list: D005663:Furans; D010975:Platelet Aggregation Inhibitors