Strengthening of non-NMDA receptor-dependent horizontal pathways between primary and lateral secondary visual cortices after NMDA receptor-dependent oscillatory neural activities.
Emergence of oscillatory signal flows between the primary visual cortex (Oc1) and medial secondary visual cortex (Oc2M) was previously dynamically demonstrated in rat brain slices by us. Applying caffeine, a neural modulator, to the slices and using optical recording methods revealed this facilitation along horizontal intrinsic pathways in which initial forward propagation from Oc1 to Oc2M was dependent on both N-methyl-D-aspartate receptors (NMDARs) and non-NMDARs. Conversely, oscillatory backward propagation from Oc2M to Oc1 was entirely dependent on NMDARs. The present study examined: (1) whether the signal behavior between Oc1 and lateral secondary visual cortex (Oc2L) is based on the same mechanism with that between Oc1 and Oc2M; and (2) how non-NMDAR and NMDAR activities underlie opening of horizontal corticocortical pathways between Oc1 and Oc2. Under NMDAR blockade, signals elicited in the Oc1 either could not or only weakly penetrated the Oc2L, even in caffeine-containing medium. In contrast, once forward propagation from Oc1 to Oc2L and oscillatory backward propagation from Oc2L to Oc1 was established in caffeine-containing medium, signals elicited in Oc1 could strongly penetrate the Oc2 even during blockade of NMDA activities, when forward penetrating components were dependent on non-NMDARs. These findings suggest that: (1) signal behavior and its mechanism between Oc1and Oc2L are the same with those between Oc1 and Oc2M; and (2) NMDAR activation results in non-NMDAR activity, resulting in opening and strengthening of intrinsic signal pathways between Oc1 and Oc2. NMDAR-dependent forward and backward propagation might be involved in cortical reorganization of the visual cortex.
Yoshimura
Hiroshi
H
Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Uchinada-cho 920-0293, Japan. hyoshimu@kanazawa-med.ac.jp
Sugai
Tokio
T
Segami
Natsuki
N
Onoda
Norihiko
N
D000818:Animals; D001683:Biological Clocks / Q000187:drug effects / Q000502:physiology*; D002110:Caffeine / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D014793:Visual Cortex / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D014795:Visual Pathways / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*
D000697:Central Nervous System Stimulants; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D002110:Caffeine