[Study of Shugan Yiyang capsule on erectile dysfunction].
OBJECTIVE
To study the pharmacological effect of Shugan Yiyang(SGYY) capsule.


METHODS
kongming mice and Wistar rats were used to observe the effects of SGYY capsule on sexual desire, erection, ejaculation and fatigue. The weight of prostate, seminal vesicle, testes, levators and thymus and serum testosterone level were also measured. Furthermore, Rhesus monkey were used to construct animal model of erectile dysfunction. Effects of SGYY capsule on sexual behavior, penile blood flow and electromyogram were observed.


RESULTS
SGYY capsule can remarkably reduce the incubation period of erection, ejaculation and innovate the sexual desire,erection, ejaculation both on rats and rhesus monkeys. The weight of prostate, seminal vesicle, testes, levators in mice and serum testosterone level of rats increased while the weight of thymus decreased. It can also diminish the luminar of vein and reduce the venous outflow while the transmission of peripheral nervous system remained stable.


CONCLUSIONS
SGYY capsule can remarkably improve the erectile activity, sexual desire and ejaculatory activity. The mechanism of SGYY capsule may be related to the increase of androgen and adrenocorticohormone levels. as well as the reduction of penile venous outflow. [Key words] shuganyiyang capsule; er
Wang
Q
Q
School of Basic Medicine, Beijing University of Traditional Chinese Medicine, Beijing 100029, China. qifang251@sina.com
Ni
Ping
P
Wu
Wei-Ping
WP
Xia
Zhong-Yuan
ZY
D000818:Animals; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004542:Ejaculation / Q000187:drug effects; D007172:Erectile Dysfunction / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005837:Genitalia, Male / Q000033:anatomy & histology; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010410:Penile Erection / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013739:Testosterone