Bisnortriterpenes from Salacia madagascariensis.
A new bisnortriterpene quinone methide, 20-epi-isoiguesterinol (2), and a new 6-oxophenolic triterpene, 6-oxoisoiguesterin (5), as well as two known compounds, isoiguesterin (1) and isoiguesterinol (4), were isolated from the petroleum ether extract of the roots of Salacia madagascariensis. Isoiguesterin (1) and 20-epi-isoiguesterinol (2) showed potent activity against Leishmania.
Thiem
Deborah A
DA
Department of Chemistry, Virginia Commonwealth University, P.O. Box 842006, Richmond, VA 23284-2006, USA.
Sneden
Albert T
AT
Khan
Shabana I
SI
Tekwani
Babu L
BL
D000818:Animals; D029753:Celastraceae / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013636:Tanzania; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D014315:Triterpenes