title: Biological half-life of bromide in the rat depends primarily on the magnitude of sodium intake.
abstract: The parallel course of the excretion rates of bromide and sodium ions was demonstrated in adult male and female rats administered simultaneously with potassium 82Br-bromide and 24Na-sodium chloride. The animals were exposed to various intakes of sodium ions accompanied with five different anions: Br-, Cl-, HCO3-, ClO4-, and SCN-. Regardless of the anion accompanying the sodium ion, the excretion rates of 82Br- and 24Na+ ions were proportional to the magnitude of sodium intake in the animals. Hence, we have proved our hypothesis that the biological half-life of bromide depends on the magnitude of sodium intake rather than on the intake of chloride.
authors.affiliation: Institute of Physiology, Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20 Pragu 4, Czech Republic. pavelka@biomed.cas.cz
authors.forename: S
authors.initials: S
authors.lastname: Pavelka
authors.forename: A
authors.initials: A
authors.lastname: Babický
authors.forename: M
authors.initials: M
authors.lastname: Vobecký
mesh_terms: D000818:Animals; D001965:Bromides / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D001967:Bromine Radioisotopes; D005260:Female; D006207:Half-Life; D008297:Male; D010472:Perchlorates / Q000008:administration & dosage; D017680:Potassium Compounds / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D017693:Sodium Bicarbonate / Q000008:administration & dosage; D012965:Sodium Chloride / Q000008:administration & dosage; D017670:Sodium Compounds / Q000008:administration & dosage; D012979:Sodium Radioisotopes
chemical_list: D001965:Bromides; D001967:Bromine Radioisotopes; D010472:Perchlorates; D017680:Potassium Compounds; D017670:Sodium Compounds; D012979:Sodium Radioisotopes; D012965:Sodium Chloride; D017693:Sodium Bicarbonate; C031068:sodium perchlorate; D012964:Sodium; C039004:potassium bromide