title: Mycobacterium tuberculosis infection and FHIT gene alterations in lung cancer.
abstract: Although it is fairly well accepted that pulmonary tuberculosis is a major risk factor of lung cancer, the exact molecular mechanisms involved in its tumorigenesis are unclear. For this purpose, we have examined the relationship between Mycobacterium tuberculosis (M-TB) infection and FHIT gene alteration in lung cancer. Tumors with M-TB infection had a slightly higher abnormal FHIT protein expression compared with tumors without M-TB infection, although not statistically significant (Fisher's exact test, P=0.248). LOH affecting at least one locus of the FHIT gene was significantly more frequent in lung cancer patients with M-TB infection than in patients without M-TB infection whether assessment by univariate testing methods or logistic regression modeling analysis (Fisher's exact test P=0.025, logistic regression analysis P=0.012). These results indicate that M-TB infection is associated with FHIT gene LOH in lung cancer.
authors.affiliation: Department of Pathology, Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China. yanws@fimmu.com
authors.forename: Lanying
authors.initials: L
authors.lastname: Song
authors.forename: Wensheng
authors.initials: W
authors.lastname: Yan
authors.forename: Tong
authors.initials: T
authors.lastname: Zhao
authors.forename: Min
authors.initials: M
authors.lastname: Deng
authors.forename: Shilin
authors.initials: S
authors.lastname: Song
authors.forename: Jinhua
authors.initials: J
authors.lastname: Zhang
authors.forename: Meigang
authors.initials: M
authors.lastname: Zhu
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000235:genetics*; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity; D008175:Lung Neoplasms / Q000150:complications / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000235:genetics; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase