A self-assembling protein template for constrained synthesis and patterning of nanoparticle arrays.
Self-assembling biomolecules that form highly ordered structures have attracted interest as potential alternatives to conventional lithographic processes for patterning materials. Here, we introduce a general technique for patterning nanoparticle arrays using two-dimensional crystals of genetically modified hollow protein structures called chaperonins. Constrained chemical synthesis of transition metal nanoparticles is initiated using templates functionalized with polyhistidine sequences. These nanoparticles are ordered into arrays because the template-driven synthesis is constrained by the nanoscale structure of the crystallized protein. We anticipate that this system may be used to pattern different classes of nanoparticles based on the growing library of sequences shown to specifically bind or direct the growth of materials.
McMillan
R Andrew
RA
NASA Ames Research Center, Moffett Field, California 94035, USA.
Howard
Jeanie
J
Zaluzec
Nestor J
NJ
Kagawa
Hiromi K
HK
Mogul
Rakesh
R
Li
Yi-Fen
YF
Paavola
Chad D
CD
Trent
Jonathan D
JD
D000497:Alloys / Q000737:chemistry*; D019843:Archaeal Proteins; D018833:Chaperonins / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D006360:Heat-Shock Proteins / Q000737:chemistry*; D018832:Molecular Chaperones / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D015202:Protein Engineering; D021122:Protein Subunits / Q000737:chemistry
D000497:Alloys; D019843:Archaeal Proteins; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D021122:Protein Subunits; C072010:TF55 protein, Sulfolobus shibatae; C099370:palladium-cobalt alloy; C050456:nickel-palladium alloy; D003035:Cobalt; D010165:Palladium; D009532:Nickel; D018833:Chaperonins