title: Amplitude-modulated continuous arterial spin-labeling 3.0-T perfusion MR imaging with a single coil: feasibility study.
abstract: Written informed consent was obtained prior to all human studies after the institutional review board approved the protocol. A continuous arterial spin-labeling technique with an amplitude-modulated control was implemented by using a single coil at 3.0 T. Adiabatic inversion efficiency at 3.0 T, comparable to that at 1.5 T, was achieved by reducing the amplitude of radiofrequency pulses and gradient strengths appropriately. The amplitude-modulated control provided a good match for the magnetization transfer effect of labeling pulses, allowing multisection perfusion magnetic resonance imaging of the whole brain. Comparison of multisection continuous and pulsed arterial spin-labeling methods at 3.0 T showed a 33% improvement in signal-to-noise ratio by using the former approach.
authors.affiliation: Department of Radiology, and Center for Functional Neuroimaging, University of Pennsylvania, 3 W Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA. wangj3@mail.med.upenn.edu
authors.forename: Jiongjiong
authors.initials: J
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Wolf
authors.forename: Anne C
authors.initials: AC
authors.lastname: Roc
authors.forename: David C
authors.initials: DC
authors.lastname: Alsop
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods / Q000706:statistics & numerical data; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male