title: Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis.
abstract: To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.
authors.affiliation: Division of Haematology, Washington University, St. Louis, Missouri 63110-1093, USA. gbroze@im.wustl.edu
authors.forename: Ali
authors.initials: A
authors.lastname: Al-Shanqeeti
authors.forename: Astrid
authors.initials: A
authors.lastname: van Hylckama Vlieg
authors.forename: Erik
authors.initials: E
authors.lastname: Berntorp
authors.forename: Frits R
authors.initials: FR
authors.lastname: Rosendaal
authors.forename: George J
authors.initials: GJ
authors.lastname: Broze
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000032:analysis* / Q000187:drug effects / Q000502:physiology; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015843:Serpins / Q000097:blood* / Q000187:drug effects / Q000502:physiology; D020246:Venous Thrombosis / Q000097:blood* / Q000209:etiology; D014859:Warfarin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D001798:Blood Proteins; D003276:Contraceptives, Oral; C416370:SERPINA10 protein, human; D015843:Serpins; C026080:plasma protein Z; D014859:Warfarin