Intensity-modulated radiotherapy: is xerostomia still prevalent?
Conformal radiation with intensity-modulated radiotherapy (IMRT) is a technique that potentially can minimize the dose to salivary glands and thereby decrease the incidence of xerostomia. Precise target determination and delineation is most important when using salivary gland-sparing techniques of IMRT. Reduction of xerostomia can be achieved by sparing the salivary glands on the uninvolved oral cavity and keeping the mean parotid gland dose of less than 26 to 30 Gy as a planning criterion if the treatment of disease is not compromised and parotid function preservation is desired.
Chambers
Mark S
MS
Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009, USA. mchamber@mdanderson.org
Garden
Adam S
AS
Rosenthal
David
D
Ahamad
Anesa
A
Schwartz
David L
DL
Blanco
Angel I
AI
Chao
K S Clifford
KS
Morrison
William H
WH
Ang
K Kian
KK
Weber
Randal S
RS
D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D004307:Dose-Response Relationship, Radiation; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy; D010307:Parotid Neoplasms / Q000532:radiotherapy; D015995:Prevalence; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods*; D012469:Salivary Glands / Q000528:radiation effects; D014987:Xerostomia / Q000453:epidemiology* / Q000209:etiology
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