Recombinant factor VIIa is an effective therapy for abdominal surgery and severe thrombocytopenia: a case report.
A 50-year-old woman was admitted to the emergency room. An appendectomy was done. On the sixth day the patient's general state deteriorated and she became somnolent with jaundice due to distal obstructive choledocholithiasis. The results of laboratory tests were platelets 12 x 10(9)/L, prothrombin time 13 seconds, international normalized ratio 1.19, activated partial thromboplastin time 31.8 seconds, and fibrinogen 8.78 g/L. There was no evidence of disseminated intravascular coagulation. In view of the patient's clinical condition, surgery was considered to be indicated. Because it was a life-threatening situation and at the time there was no platelet concentrate available for immediate transfusion, she was treated with a single dose of recombinant factor VIIa (rFVIIa) (60 microg/kg). The dose of 60 microg/kg was selected on the basis of experience with rFVIIa in the treatment of hemophilic patients. In this case, use of rFVIIa was a valid alternative to control the bleeding in a patient with thrombocytopenia. However, despite the efficacy of the treatment, it should not be forgotten that it was used because of the unavailability of platelets and that we were dealing with a life-threatening situation. Clinical trials should be carried out to verify the safety, effectiveness, and efficiency of rFVIIa in these cases.
Conesa
Venancio
V
Hematology Service, Hospital General Universitario de Elche, Elche, Alicante, Spain.
Navarro-Ruiz
Andrés
A
Borrás-Blasco
Joaquín
J
Mompel
Angela
A
Gómez
Amparo
A
González
Mercedes
M
D000005:Abdomen / Q000601:surgery; D042883:Choledocholithiasis / Q000601:surgery*; D016638:Critical Illness; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000188:drug therapy*
D011994:Recombinant Proteins; D015942:Factor VIIa
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