Equisetin biosynthesis in Fusarium heterosporum.
An iterative polyketide synthase-peptide synthetase hybrid assembles the HIV-1 integrase inhibitory tetramic acid, equisetin, in the filamentous fungus Fusarium heterosporum.
Sims
James W
JW
Department of Medicinal Chemistry, University of Utah, 30 South 2000 East Rm 201, Salt Lake City, UT 84112, USA.
Fillmore
John P
JP
Warner
Douglas D
DD
Schmidt
Eric W
EW
D005670:Fusarium / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D017353:Gene Deletion; D005800:Genes, Fungal; D015394:Molecular Structure; D005810:Multigene Family; D011760:Pyrrolidinones / Q000737:chemistry / Q000378:metabolism*; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000378:metabolism*
D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes; C024509:equisetin