title: Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs).
abstract: A series of [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines were designed and synthesized as CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBA's).
authors.affiliation: OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. mark.mulvihill@osip.com
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mulvihill
authors.forename: Julie L C
authors.initials: JL
authors.lastname: Kan
authors.forename: Patricia
authors.initials: P
authors.lastname: Beck
authors.forename: Mark
authors.initials: M
authors.lastname: Bittner
authors.forename: Cara
authors.initials: C
authors.lastname: Cesario
authors.forename: Andrew
authors.initials: A
authors.lastname: Cooke
authors.forename: David M
authors.initials: DM
authors.lastname: Keane
authors.forename: Anthony I
authors.initials: AI
authors.lastname: Nigro
authors.forename: Christy
authors.initials: C
authors.lastname: Nillson
authors.forename: Vanessa
authors.initials: V
authors.lastname: Smith
authors.forename: Mary
authors.initials: M
authors.lastname: Srebernak
authors.forename: Feng-Lei
authors.initials: FL
authors.lastname: Sun
authors.forename: Michael
authors.initials: M
authors.lastname: Vrkljan
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Winski
authors.forename: Arlindo L
authors.initials: AL
authors.lastname: Castelhano
authors.forename: David
authors.initials: D
authors.lastname: Emerson
authors.forename: Neil
authors.initials: N
authors.lastname: Gibson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System; D004123:Dimethylamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D008861:Microsomes / Q000201:enzymology; D051381:Rats; D000072516:Retinoic Acid 4-Hydroxylase
chemical_list: D000970:Antineoplastic Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D004123:Dimethylamines; D007093:Imidazoles; D003577:Cytochrome P-450 Enzyme System; D000072516:Retinoic Acid 4-Hydroxylase