title: Functional promotor polymorphism in RANTES gene does not influence the clinical course of Helicobacter pylori infection.
abstract: OBJECTIVE
  Helicobacter pylori was found to increase the transcription of RANTES as a potent chemoattractant cytokine in mucosal inflammation. The aim of this study was to test if a functional promotor polymorphism in the RANTES gene leading to a higher transcriptional activity influences the severity of the mucosal damage in H. pylori infected individuals.
  
  
  METHODS
  A single nucleotide polymorphism, C-471T, was genotyped by TaqMan technology in a sample of 344 consecutive patients with H. pylori infection undergoing upper gastrointestinal endoscopy and 370 blood donors. Association with the development of erosions and stomach or duodenum ulcers as well as atrophic gastritis were tested.
  
  
  RESULTS
  None of the genotypes were associated with the severity of mucosal damage in stomach or duodenum (P > 0.05).
  
  
  CONCLUSIONS
  Even though H. pylori itself induces expression of RANTES, at the transcriptional level, genetic variations leading to higher transcriptional activity do not modify the degree of inflammation.
authors.affiliation: Department of General Internal Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Germany. s.hellmig@mucosa.de
authors.forename: Stephan
authors.initials: S
authors.lastname: Hellmig
authors.forename: Silvia
authors.initials: S
authors.lastname: Mascheretti
authors.forename: Ulrich
authors.initials: U
authors.lastname: Fölsch
authors.forename: Stefan
authors.initials: S
authors.lastname: Schreiber
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D018946:Chemokine CCL5 / Q000235:genetics* / Q000378:metabolism; D004247:DNA / Q000032:analysis; D004381:Duodenal Ulcer / Q000209:etiology; D004384:Duodenoscopy; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D005757:Gastritis, Atrophic / Q000209:etiology; D005773:Gastroscopy; D005838:Genotype; D016481:Helicobacter Infections / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000209:etiology
chemical_list: D018946:Chemokine CCL5; D004247:DNA