title: Identification from a positional scanning peptoid library of in vivo active compounds that neutralize bacterial endotoxins.
abstract: Two peptoids that neutralize the Gram-negative lipopolysaccharide (LPS) were identified from the screening of a positional scanning library. The evaluation of the in vivo activity of these compounds in an endoxemia murine model is also reported. These peptoids did not neutralize lipid A, i.e., the hydrophobic toxic component of LPS. This fact suggests that they do not have access to the micellar core and that they should bind to the hydrophilic carbohydrate portion of LPS.
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Universitat de València, E-46100 Burjassot, Spain.
authors.forename: Puig
authors.initials: P
authors.lastname: Mora
authors.forename: Isabel
authors.initials: I
authors.lastname: Masip
authors.forename: Nuria
authors.initials: N
authors.lastname: Cortés
authors.forename: Regina
authors.initials: R
authors.lastname: Marquina
authors.forename: Ramón
authors.initials: R
authors.lastname: Merino
authors.forename: Jesús
authors.initials: J
authors.lastname: Merino
authors.forename: Teresa
authors.initials: T
authors.lastname: Carbonell
authors.forename: Ismael
authors.initials: I
authors.lastname: Mingarro
authors.forename: Angel
authors.initials: A
authors.lastname: Messeguer
authors.forename: Enrique
authors.initials: E
authors.lastname: Pérez-Payá
mesh_terms: D000818:Animals; D016208:Databases, Factual; D006090:Gram-Negative Bacteria / Q000737:chemistry; D008050:Lipid A / Q000737:chemistry; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000737:chemistry; D051379:Mice; D034444:Peptoids / Q000737:chemistry* / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D008050:Lipid A; D008070:Lipopolysaccharides; D034444:Peptoids; D014409:Tumor Necrosis Factor-alpha