title: Bisnortriterpenes from Salacia madagascariensis.
abstract: A new bisnortriterpene quinone methide, 20-epi-isoiguesterinol (2), and a new 6-oxophenolic triterpene, 6-oxoisoiguesterin (5), as well as two known compounds, isoiguesterin (1) and isoiguesterinol (4), were isolated from the petroleum ether extract of the roots of Salacia madagascariensis. Isoiguesterin (1) and 20-epi-isoiguesterinol (2) showed potent activity against Leishmania.
authors.affiliation: Department of Chemistry, Virginia Commonwealth University, P.O. Box 842006, Richmond, VA 23284-2006, USA.
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Thiem
authors.forename: Albert T
authors.initials: AT
authors.lastname: Sneden
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.forename: Babu L
authors.initials: BL
authors.lastname: Tekwani
mesh_terms: D000818:Animals; D029753:Celastraceae / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013636:Tanzania; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D014315:Triterpenes