title: Synthesis of a beta-amino acid pharmacophore via a beta-lactam intermediate.
abstract: A stereoselective synthesis of (R)-beta-amino acid 1 via a beta-lactam intermediate is discussed.
authors.affiliation: Merck Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. remy_angelaud@merck.com
authors.forename: Rémy
authors.initials: R
authors.lastname: Angelaud
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Zhong
authors.forename: Peter
authors.initials: P
authors.lastname: Maligres
authors.forename: Jaemoon
authors.initials: J
authors.lastname: Lee
authors.forename: David
authors.initials: D
authors.lastname: Askin
mesh_terms: D000215:Acylation; D000596:Amino Acids / Q000138:chemical synthesis*; D015195:Drug Design; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D047090:beta-Lactams / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D047090:beta-Lactams