The role of ICAM-1 in Plasmodium falciparum cytoadherence.
Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1) and its role in mediating the interaction between the parasitised red blood cell (PRBC) and the vascular endothelium. We highlight the nature of the interaction between ICAM-1 and the parasite-expressed PfEMP-1 molecule at the molecular level. The review also discusses the complexity of the PRBC-endothelial cell interaction and the mechanisms that underlie parasite cytoadherence.
Chakravorty
Srabasti J
SJ
Liverpool School of Tropical Medicine, University of Liverpool, Liverpool L3 5QA, UK. chakrasj@liverpool.ac.uk
Craig
Alister
A
D000818:Animals; D001921:Brain / Q000469:parasitology; D002448:Cell Adhesion; D018360:Crystallography, X-Ray; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000378:metabolism; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000502:physiology*; D008288:Malaria / Q000473:pathology; D008958:Models, Molecular; D010963:Plasmodium falciparum / Q000472:pathogenicity*; D011110:Polymorphism, Genetic; D011485:Protein Binding; D017434:Protein Structure, Tertiary
D018799:Intercellular Adhesion Molecule-1