title: Environmental light and heredity are associated with adaptive changes in retinal DHA levels that affect retinal function.
abstract: Retinas of rats and mice react to environmental and genetic stimuli by altering the level of DHA in their rod outer segment membranes. We propose that this adaptation is a neuroprotective response to control the number of photons captured by rhodopsin and the efficiency of visual transduction, under conditions where excessive activation of the transduction cascade could lead to cell death.
authors.affiliation: Department of Cell Biology, University of Oklahoma Health Sciences Center, and Dean A. McGee Eye Institute, Oklahoma City, OK, USA. robert-anderson@ouhsc.edu
authors.forename: Robert E
authors.initials: RE
authors.lastname: Anderson
authors.forename: John S
authors.initials: JS
authors.lastname: Penn
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004032:Diet; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D040941:Heredity / Q000502:physiology*; D006801:Humans; D012160:Retina / Q000187:drug effects / Q000378:metabolism / Q000502:physiology* / Q000528:radiation effects*; D013472:Sunlight
chemical_list: D004281:Docosahexaenoic Acids
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