Study on structure and characterization of inclusion complex of gossypol/beta cyclodextrin.
The inclusion complex of beta-cyclodextrin with gossypol was synthesized by using a convenient method of microwave irradiation. The structure of the complex was determined by 1H NMR, IR spectroscopy, and as well as the elemental analysis; the thermal stability was studied by means of differential thermal analysis (DTA) and thermogravimetric analysis (TGA). The association constant between gossypol and beta-cyclodextrin measured via UV spectroscopy was 4462M(-1) at room temperature, following stoichiometry 1:2.
Shen
Ying-lin
YL
Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. shenyinglin@sohu.com
Yang
Sheng-hua
SH
Wu
Long-min
LM
Ma
Xue-yi
XY
D002273:Carcinogens / Q000737:chemistry*; D003272:Contraceptive Agents, Male / Q000737:chemistry / Q000378:metabolism; D006072:Gossypol / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D008956:Models, Chemical; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
D002273:Carcinogens; D003272:Contraceptive Agents, Male; D012997:Solvents; D047392:beta-Cyclodextrins; C031215:betadex; D006072:Gossypol