title: Ruptured saccular aneurysm of distal vertebral artery fenestration managed with Guglielmi detachable coils and intraventricular tissue plasminogen activator.
abstract: BACKGROUND
  Aneurysms associated with vertebrobasilar fenestrations are uncommon. We report on an unusual presentation of such aneurysm with a dedicated arterial pedicle, manifesting with significant intraventricular hemorrhage. Equally important, the aneurysm was managed in a multidisciplinary fashion, which, we think, greatly contributed to a good outcome.
  
  
  METHODS
  A 55-year-old man presented in good condition after subarachnoid and massive intraventricular hemorrhage. The aneurysm location and the extent of intraventricular hemorrhage both presented concerns regarding treatment approach. The aneurysm was first treated with transarterial coil obliteration, and intraventricular tissue plasminogen activator (tPA) infusion was given, with rapid resolution of evolving hydrocephalus. The patient had an excellent outcome.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of a vertebrobasilar fenestration saccular aneurysm with a dedicated pedicle projecting toward the foramen of Magendie with significant intraventricular hemorrhage. In addition, this patient was successfully managed with endovascular obliteration and intraventricular tPA infusion.
authors.affiliation: Division of Neuroradiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
authors.forename: Michiya
authors.initials: M
authors.lastname: Kubo
authors.forename: Lotfi
authors.initials: L
authors.lastname: Hacein-Bey
authors.forename: Panayiotis N
authors.initials: PN
authors.lastname: Varelas
authors.forename: John L
authors.initials: JL
authors.lastname: Ulmer
authors.forename: Denise M
authors.initials: DM
authors.lastname: Lemke
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Cusick
mesh_terms: D017542:Aneurysm, Ruptured / Q000000981:diagnostic imaging / Q000628:therapy*; D002533:Cerebral Angiography; D020546:Fourth Ventricle / Q000000981:diagnostic imaging; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D007276:Injections, Intraventricular; D002532:Intracranial Aneurysm / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000295:instrumentation* / Q000379:methods; D011183:Postoperative Complications; D019736:Prostheses and Implants; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000295:instrumentation* / Q000379:methods; D014711:Vertebral Artery / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000601:surgery*
chemical_list: D010959:Tissue Plasminogen Activator