title: Oxidative status during late pregnancy and early lactation in dairy cows.
abstract: In the last few years, the detection of free radical damage and the body's defences against it have become increasingly important in clinical medicine as a complementary tool in the evaluation of metabolic status. The aim of this study was to evaluate, under field conditions, the anti-oxidant status of healthy cows during late pregnancy and lactation onset using two parameters: (1) plasma levels of malondialdehyde (MDA), a degradation product of lipid peroxidation, and (2) total antioxidant status (TAS). Results were compared with those obtained in another group of cows with lesser metabolic demands. We also investigated possible relationships between antioxidant status markers and other relevant blood parameters. Our results confirmed the characteristic metabolic changes associated with late pregnancy and early lactation. MDA and TAS provided an accurate reflection of the internal physiological status of the animal. The data indicated increased lipid peroxidation around parturition, but with wide individual variations that may be attributable not only to the physiological stage but also to unknown factors that will have to be further considered in future studies.
authors.affiliation: Departamento de Patología Animal, Facultad de Veterinaria, Campus Universitario s/n, Universidad de Santiago de Compostela, 27002 Lugo, Spain. ccasti@lugo.usc.es
authors.forename: C
authors.initials: C
authors.lastname: Castillo
authors.forename: J
authors.initials: J
authors.lastname: Hernandez
authors.forename: A
authors.initials: A
authors.lastname: Bravo
authors.forename: M
authors.initials: M
authors.lastname: Lopez-Alonso
authors.forename: V
authors.initials: V
authors.lastname: Pereira
authors.forename: J L
authors.initials: JL
authors.lastname: Benedito
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose; D002417:Cattle; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003612:Dairying; D005260:Female; D007774:Lactation / Q000097:blood*; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D012709:Serum Albumin; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D012709:Serum Albumin; D014280:Triglycerides; D008315:Malondialdehyde; D014508:Urea; D002784:Cholesterol; D003404:Creatinine