Generalized tonic-clonic status epilepticus in the elderly in China.
The proportion of elderly people in China is projected to increase rapidly but there is limited information on status epilepticus (SE) in this population. We evaluated retrospectively the etiology, response to treatment, outcome and predictors of mortality in a group of elderly patients with generalized tonic-clonic SE in Hong Kong, China. Factors for increased mortality were analyzed using a logistic regression model. Of the 80 acute admissions for SE from two large urban hospitals over a seven-year period, 1996-2002, the two leading causes were attributed to cerebral infarct (n=28, 35%) and cerebral haemorrhage (n=14, 17.5%). The mean age was 74.2 years (range 60-93 years). At six months from the onset of seizures, 26 patients (32.5%) had made a good recovery but another 28 (35%) had died. Results showed that mortality was associated with increasing age (OR 1.08, 95% CI 1.01-1.16) and SE due to an acute symptomatic disturbance (OR 4.90, 95% CI 1.17-13.67). SE is associated with significant morbidity and mortality in this age group.
Hui
Andrew C F
AC
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR. cfhui@cuhk.edu.hk
Lam
Anita K
AK
Wong
Adrian
A
Chow
Kai-Ming
KM
Chan
Eric L Y
EL
Choi
Simon L
SL
Wong
Ka-Shing
KS
D017668:Age of Onset; D000368:Aged / Q000706:statistics & numerical data*; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D004829:Epilepsy, Generalized / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D004830:Epilepsy, Tonic-Clonic / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013226:Status Epilepticus / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D009626:Terminology as Topic; D016896:Treatment Outcome