title: Treatment of chronic hepatitis B with lamivudine.
abstract: OBJECTIVE
  To study the efficacy of antiviral drug lamivudine for treatment of chronic hepatitis B in Pakistani population.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  A tertiary Care Center, from January 2000 to January 2004.
  
  
  METHODS
  Patients who had positive hepatitis B surface antigen (HBsAg) and elevated ALT were recruited. Both hepatitis Be antigen (HBeAg) positive and HBeAg negative patients were included. Treatment was given with lamivudine 100mg once a day for 12 months and they were followed every 2-3 months with ALT, HBeAg, and in certain cases with, HBV DNA (PCR). Those patients who were HBeAg positive were considered to have achieved end of treatment response (ETR) when ALT was normal and HBeAg was negative and this was documented at two consecutive occasions, at least one month apart. Those patients who were HBeAg negative were considered to have achieved ETR when their ALT was normal and HBV DNA was undetectable. Patients were followed for further 6 months to evaluate for any relapse.
  
  
  RESULTS
  A total of 105 patients were included. Eighty-two (78.1%) were males and 23 (21.9%) were females. Mean ALT of all patients was 87.15 +/- 46.01 u/dl. Seventy-two HBeAg positive and 15 HBeAg negative patients completed treatment with 23.6 % and 80.0 % response rate respectively (p <0.001).
  
  
  CONCLUSIONS
  The response of lamivudine in chronic hepatitis B in Pakistani population is encouraging in HBeAg negative patients but is rather low in those who are HBeAg positive.
authors.affiliation: Department of Medicine, Shifa International Hospital and College of Medicine, Islamabad, Pakistan. dmkhokhar@yahoo.com
authors.forename: Nasir
authors.initials: N
authors.lastname: Khokhar
authors.forename: Muzaffar Lateef
authors.initials: ML
authors.lastname: Gill
authors.forename: Ali Yawar
authors.initials: AY
authors.lastname: Alam
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008297:Male; D010154:Pakistan; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine; D000410:Alanine Transaminase