title: Hepatosplenic large cell immunoblastic lymphoma in a bottlenose dolphin (Tursiops truncatus) with high levels of polychlorinated biphenyl congeners.
abstract: This report describes a large cell immunoblastic lymphoma in a bottlenose dolphin found stranded alive in Gran Canaria, Spain. Diffuse infiltration of round neoplastic cells was observed in the splenic cords and sinuses and in hepatic sinusoids, resulting in moderate organ enlargement. The tumour cells (immunophenotype IgG+ and CD3-) showed scant, lightly eosinophilic or basophilic cytoplasm, distinct cell boundaries and hyperchromatic nuclei, each with one or more nucleoli. Mitoses were common. On the basis of histopathological, immunohistochemical and ultrastructural features, the tumour was classified as an immunoblastic lymphoma. Eleven polychlorinated biphenyl (PCB) congeners, 23 organochlorine pesticides and 16 polycyclic aromatic hydrocarbons (PAHs) were detected in the blubber and liver. High concentrations of PCBs 153, 180, 138 and 187 found in the liver may have been associated with the hepatosplenic lymphoma.
authors.affiliation: Departamento de Morfología, Facultad de Veterinaria de Las Palmas de Gran Canaria, Las Palmas, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Jaber
authors.forename: J
authors.initials: J
authors.lastname: Pérez
authors.forename: M
authors.initials: M
authors.lastname: Carballo
authors.forename: M
authors.initials: M
authors.lastname: Arbelo
authors.forename: A
authors.initials: A
authors.lastname: Espinosa de los Monteros
authors.forename: P
authors.initials: P
authors.lastname: Herráez
authors.forename: J
authors.initials: J
authors.lastname: Muñoz
authors.forename: M
authors.initials: M
authors.lastname: Andrada
authors.forename: F
authors.initials: F
authors.lastname: Rodríguez
authors.forename: A
authors.initials: A
authors.lastname: Fernández
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D017252:CD3 Complex / Q000032:analysis; D004289:Dolphins; D004785:Environmental Pollutants / Q000009:adverse effects / Q000032:analysis; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007074:Immunoglobulin G / Q000032:analysis; D016130:Immunophenotyping / Q000662:veterinary; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011078:Polychlorinated Biphenyls / Q000009:adverse effects / Q000032:analysis; D013160:Splenic Neoplasms / Q000473:pathology / Q000662:veterinary*
chemical_list: D017252:CD3 Complex; D004785:Environmental Pollutants; D007074:Immunoglobulin G; D011078:Polychlorinated Biphenyls