[Proteinuria-induced mechanisms of tubulointerstitial remodeling and possibilities of nephroprotection in glomerulonephritis].
The authors describe various mechanisms (including cellular and molecular ones) that mediate the realization of interstitial inflammation under the influence of proteinuria components. The paper covers epithelial cell transdifferentiation processes, the role of angiotensin II, transforming growth factor beta, nuclear transcription factor NFkB, chemokines, endothelial factors etc. The effects of drugs routinely used in nephrology at present (angiotensin converting enzyme inhibitors, statines etc.) are presented in a new way according to the modern conception of the mechanisms of proteinuria-induced renal interstitial tissue remodeling in glomerulonephritis. The authors consider administration of antichemokine agents, which influences chemokine/chemokine receptor system, to be a prospective independent immunotherapeutic direction in treatment, aimed at prevention of glomerulonephritis progression.
Mykhin
N A
NA
Kozlovskaia
L V
LV
Bobkova
I N
IN
Plieva
O K
OK
Chebotareva
N V
NV
Shcherbak
A V
AV
D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005921:Glomerulonephritis / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism / Q000473:pathology*; D011507:Proteinuria / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D018121:Receptors, Cytokine / Q000378:metabolism
D016207:Cytokines; D018121:Receptors, Cytokine