Genetic analysis of complex cardiovascular traits in the spontaneously hypertensive rat.
Identification of the genetic determinants of common diseases is a major challenge for current biomedical research. Combining linkage analyses of essentially monogenic cis-regulated expression phenotypes with oligogenic intermediate physiological phenotypes represents a promising approach for identification of quantitative trait loci at the molecular level. In the present review, a genetic analysis of cardiovascular phenotypes studied at several levels of complexity in rat recombinant inbred strains is described.
Pravenec
Michal
M
Institute of Physiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague 4, Czech Republic. pravenec@biomed.cas.cz
Kren
Vladimír
V
D000818:Animals; D030801:Animals, Genetically Modified; D020869:Gene Expression Profiling / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism*; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics*; D051381:Rats / Q000235:genetics* / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics*
D014157:Transcription Factors