Role of individual structural features of rabbit kidneys in the predisposition to gentamicin nephrotoxicity.
A relationship between congenital features in the structure of rabbit kidneys and sensitivity to gentamicin nephrotoxicity was revealed. Gentamicin nephrotoxicity is more pronounced in rabbits with lower diameter of nephron convoluted tubules and with smaller cells lining their lumen.
Bushma
K M
KM
Medical University, Ministry of Health of Republic of Belarus', Grodno, Belarus. pharma@grsmu.by
Kizyukevich
L S
LS
Bushma
M I
MI
Nechiporenko
N A
NA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity; D005839:Gentamicins / Q000633:toxicity*; D007668:Kidney / Q000033:anatomy & histology* / Q000187:drug effects / Q000473:pathology*; D009399:Nephrons / Q000033:anatomy & histology / Q000187:drug effects / Q000473:pathology; D011507:Proteinuria; D011817:Rabbits; D014508:Urea / Q000097:blood
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D014508:Urea