title: Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia.
abstract: OBJECTIVE
  To report on a trial of adding amisulpride to clozapine.
  
  
  METHODS
  Description of six cases.
  
  
  RESULTS
  Six patients who had been on clozapine were commenced on amisulpride. All patients had had unwanted effects with clozapine, particularly sedation, hypersalivation, or weight gain. Five patients reported a high level of satisfaction with the regimen, having a reduction in the level of sedation and improvement in levels of motivation and energy, without recurrence of positive symptoms.
  
  
  CONCLUSIONS
  The combined use of amisulpride and clozapine would appear to be an appropriate and beneficial treatment.
authors.affiliation: Bundaberg Integrated Mental Health Service, Bundaberg, Queensland 4670, Australia.
authors.forename: Brian
authors.initials: B
authors.lastname: Cook
authors.forename: Gerry
authors.initials: G
authors.lastname: Hoogenboom
mesh_terms: D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D003024:Clozapine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013469:Sulpiride / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride; D003024:Clozapine