High frequency stimulation of the subthalamic nucleus is efficacious in Parkin disease.
High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an efficacious symptomatic treatment for Parkinson's disease. We have analysed the genetic status of a series of consecutive parkinsonian patients implanted for STN HFS and compared the outcome of five carrying mutations in the parkin gene with that of the non-parkin group. All patients obtained sustained control of PD symptoms and achieved functional improvement; in the parkin group the UPDRS motor score improved by 56.4%, the levodopa equivalent daily dosage was reduced by 75.5%. Postoperative medications were reduced more in parkin than in non-parkin patients. We confirm that the current inclusion criteria for STN HFS do not exclude patients carrying mutations in the parkin gene; their clinical outcome is comparable to that of the non-parkin group.
Romito
Luigi M A
LM
Istituto Nazionale Neurologico Carlo Besta, Via G. Celoria, 11, 20133 Milano, Italy.
Contarino
Maria F
MF
Ghezzi
Daniele
D
Franzini
Angelo
A
Garavaglia
Barbara
B
Albanese
Alberto
A
D000328:Adult; D046690:Deep Brain Stimulation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics* / Q000628:therapy; D018709:Statistics, Nonparametric; D020531:Subthalamic Nucleus / Q000528:radiation effects*; D016896:Treatment Outcome; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
D044767:Ubiquitin-Protein Ligases; C111567:parkin protein
J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4
1564476
Mov Disord. 1998 Nov;13(6):885-94
9827611
Stereotact Funct Neurosurg. 2004;82(1):14-9
15007214
Brain. 2003 Jun;126(Pt 6):1271-8
12764050
Mamm Genome. 2000 Jun;11(6):417-21
10818204
Neurology. 2002 May 28;58(10):1546-50
12034798
Mov Disord. 2002 Nov;17(6):1371-4
12465087
Neurology. 1999 Jul 13;53(1):85-90
10408541
N Engl J Med. 2000 May 25;342(21):1560-7
10824074
Neurology. 2002 Sep 24;59(6):932-4
12297584
Brain. 2003 Jun;126(Pt 6):1279-92
12764051