title: Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.
abstract: Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.
authors.affiliation: School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
authors.forename: Sian M
authors.initials: SM
authors.lastname: Cooper
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Cox
authors.forename: John
authors.initials: J
authors.lastname: Crosby
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Crump
authors.forename: Joanne
authors.initials: J
authors.lastname: Hothersall
authors.forename: Wanpen
authors.initials: W
authors.lastname: Laosripaiboon
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Simpson
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Thomas
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D015394:Molecular Structure; D005810:Multigene Family / Q000235:genetics*; D016712:Mupirocin / Q000096:biosynthesis*; D016297:Mutagenesis, Site-Directed; D011551:Pseudomonas fluorescens / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D016712:Mupirocin