The architecture of the tau haplotype block in different ethnicities.
We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of approximately 2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans.
Fung
Hon Chung
HC
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Building 35, Room 1A1008, MSC 3707, Bethesda, MD 20892, USA. fungp@mail.nih.gov
Evans
Jessica
J
Evans
Whitney
W
Duckworth
Jaime
J
Pittman
Alan
A
de Silva
Rohan
R
Myers
Amanda
A
Hardy
John
J
D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D019636:Neurodegenerative Diseases / Q000208:ethnology / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D016875:tau Proteins / Q000235:genetics*
D016875:tau Proteins