title: A case of melioidosis presenting as migrating pulmonary infiltration: the first case in Korea.
abstract: Melioidosis is an infection of the Gram-negative bacterium Burkholderia pseudomallei. While it is known as an important cause of sepsis or chronic abscess-forming disease in Southeast Asia and northern Australia, no case has yet been reported in Korea. A 50-yr-old man visited our hospital for intermittent fever associated with dry cough and sputum. Roentgenographic examination showed migrating pulmonary infiltration. Symptoms and chest radiograph and computed tomography (CT) image findings did not improve despite use of fluoroquinolone antibiotics. Gram-negative bacteria were isolated on bronchoscopic washing culture and were identified as B. pseudomallei on DNA sequencing of 16S ribosomal RNA with 100% homology. Treatment for melioidosis was commenced with high dose ceftazidime, and the patient's fever, cough, and sputum were improved and the lesion on chest radiograph and CT almost disappeared.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Sei Won
authors.initials: SW
authors.lastname: Lee
authors.forename: Jongyoun
authors.initials: J
authors.lastname: Yi
authors.forename: Sae-Ik
authors.initials: SI
authors.lastname: Joo
authors.forename: Young Ae
authors.initials: YA
authors.lastname: Kang
authors.forename: Young Soon
authors.initials: YS
authors.lastname: Yoon
authors.forename: Jae Joon
authors.initials: JJ
authors.lastname: Yim
authors.forename: Chul-Gyu
authors.initials: CG
authors.lastname: Yoo
authors.forename: Sung Koo
authors.initials: SK
authors.lastname: Han
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Shim
authors.forename: Eui-Chong
authors.initials: EC
authors.lastname: Kim
authors.forename: Young Whan
authors.initials: YW
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016957:Burkholderia pseudomallei / Q000378:metabolism; D002442:Ceftazidime / Q000494:pharmacology; D003937:Diagnosis, Differential; D024841:Fluoroquinolones / Q000494:pharmacology; D006801:Humans; D007723:Korea; D008168:Lung / Q000382:microbiology*; D008171:Lung Diseases / Q000175:diagnosis / Q000382:microbiology*; D008297:Male; D008554:Melioidosis / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D012336:RNA, Ribosomal, 16S / Q000737:chemistry; D018805:Sepsis; D017422:Sequence Analysis, DNA; D013696:Temperature; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D012336:RNA, Ribosomal, 16S; D002442:Ceftazidime
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