Multiple endocrine neoplasia type 1.
Multiple endocrine neoplasia-1 (MEN-1) is an autosomal dominant inherited syndrome that occurs due to inactivating mutations of the MEN1 gene locus, coding for a tumor-suppressor protein, menin. The components of MEN-1 are hyperparathyroidism due to multiple parathyroid adenomas, pancreatic neuroendocrine tumors, and pituitary adenomas, in addition to some less common neoplastic manifestations. Care of people with MEN-1 requires knowledge of the problems that may arise, and the best approaches to detect and care for the manifestations of this incurable, but manageable, disease.
Doherty
Gerard M
GM
NW Thompson Professor of Surgery, University of Michigan, Ann Arbor, Michigan, USA. gerardd@umich.edu
D000236:Adenoma / Q000175:diagnosis; D019160:Endosonography; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D006961:Hyperparathyroidism / Q000209:etiology; D007340:Insulinoma / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D017599:Neuroectodermal Tumors / Q000000981:diagnostic imaging; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D010282:Parathyroid Neoplasms / Q000175:diagnosis; D010911:Pituitary Neoplasms / Q000601:surgery; D015175:Prolactinoma / Q000601:surgery; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D003969:Vipoma / Q000601:surgery
C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins