The development of a plant-based vaccine for measles.
Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.
Webster
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Children's Vaccines Group, MacFarlane Burnet Institute for Medical Research and Public Health, P.O. Box 2284, Melbourne, Vic. 3001, Australia. diane@burnet.edu.au
Thomas
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MC
Huang
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Wesselingh
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SL
D000284:Administration, Oral; D000818:Animals; D006388:Hemagglutinins / Q000276:immunology; D006801:Humans; D007117:Immunization, Secondary; D008457:Measles / Q000453:epidemiology / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D030781:Organisms, Genetically Modified; D030821:Plants, Genetically Modified / Q000276:immunology*
D006388:Hemagglutinins; D008458:Measles Vaccine