title: Evaluation of 11C-methionine PET as a surrogate endpoint after treatment of grade 2 gliomas.
abstract: The aim of the present study was to assess the usefulness of positron emission tomography (PET) as a surrogate endpoint by analysing the uptake variability of 11C-methionine (MET) in follow-up scans.A total of 96 PET MET scans were re-evaluated in 32 patients with histologically confirmed supratentorial grade 2 gliomas. In untreated patients, all follow-up PET scans showed an increased tumour volume after median 68 weeks, but only 46% of cases had an increased hot spot uptake. An improved outcome was observed in patients with stable hot spot uptake per se (P = 0.07) and in combinations with minor increase in tumour volume (P = 0.02). After conventional therapy, 52% of PET scans showed a reduced hot spot uptake the first year and 43% were reduced after more than a year. Successful MET decline after therapy did not correlate with outcome. PET MET may be a promising surrogate endpoint after treatment of grade 2 gliomas. Evaluation of both hot spot activity and uptake volume on PET may strengthen the association with clinical outcome.
authors.affiliation: Department of Neuroscience, Neurology, University Hospital, Uppsala, Sweden. dan.ribom@lthalland.se
authors.forename: Dan
authors.initials: D
authors.lastname: Ribom
authors.forename: Marjoleine
authors.initials: M
authors.lastname: Schoenmaekers
authors.forename: Henry
authors.initials: H
authors.lastname: Engler
authors.forename: Anja
authors.initials: A
authors.lastname: Smits
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000493:pharmacokinetics*; D002247:Carbon Isotopes / Q000493:pharmacokinetics*; D049109:Cell Proliferation / Q000187:drug effects; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D008297:Male; D008715:Methionine / Q000493:pharmacokinetics*; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods*; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012189:Retrospective Studies; D015173:Supratentorial Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D002247:Carbon Isotopes; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals; D008715:Methionine
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