title: Atopy parameters in asthmatic children increase with accumulation of null-alleles of glutathione-S-transferase M1.
abstract: Atopy parameters (total IgE, skin prick test, and peripheral blood eosinophil count) in children with atopic bronchial asthma depend on the number of glutathione-S-transferase M1 mutant alleles in the genotype and on family history of asthma.
authors.affiliation: Institute of Molecular Biology and Biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. makar@soramn.ru
authors.forename: S I
authors.initials: SI
authors.lastname: Makarova
authors.forename: O G
authors.initials: OG
authors.lastname: Safronova
authors.forename: V A
authors.initials: VA
authors.lastname: Vavilin
authors.forename: O A
authors.initials: OA
authors.lastname: Batychko
authors.forename: S M
authors.initials: SM
authors.lastname: Gavalov
authors.forename: V V
authors.initials: VV
authors.lastname: Lyakhovich
mesh_terms: D000483:Alleles; D001249:Asthma / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D002648:Child; D004804:Eosinophils; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D012882:Skin Tests
chemical_list: D005982:Glutathione Transferase; D007073:Immunoglobulin E