title: [Effect of Rhizoma pinelliae on vomiting in minks].
abstract: OBJECTIVE
  To study emetic and anti-emetic effects of Rhizoma pinelliae in minks.
  
  
  METHODS
  The emetic effect of raw pinellia 2 g kg(-1) (i.g.) was investigated. Three preparations of Rhizoma pinelliae (processed with ginger) were made by ethanol extraction, water extraction and water decoction respectively and their effects on emesis model induced by cisplatin (7.5 mg kg(-1), i.p.) or apomorphine (1.6 mg kg(-1), s.c.) were then studied; the effect of the decoction of ginger-processed Rhizoma pinelliae on rotation-induced emesis model in minks was also observed.
  
  
  RESULTS
  The emesis was induced by raw pinellia in minks (P < 0.01); ginger-processed Rhizoma pinelliae, metoclopramide and ondansetron significantly inhibit the emesis induced by cisplatin and apomorphine (P < 0.05).
  
  
  CONCLUSIONS
  Ginger-processed Rhizoma pinelliae exhibits a anti-emetic effect in minks, which may be mediated by inhibiting the function of the vomiting center in central nervous system.
authors.affiliation: Department of Pharmacology, Medical College of Qingdao University, Qingdao 266021, China.
authors.forename: Yong-juan
authors.initials: YJ
authors.lastname: Zhao
authors.forename: Zhong-qiang
authors.initials: ZQ
authors.lastname: Ji
authors.forename: Xiang-nong
authors.initials: XN
authors.lastname: Zhang
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Zhang
authors.forename: Jing-fen
authors.initials: JF
authors.lastname: Wu
authors.forename: Xuan
authors.initials: X
authors.lastname: Fang
authors.forename: Wang
authors.initials: W
authors.lastname: Yue
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D020939:Zingiber officinale; D006358:Hot Temperature; D008297:Male; D008907:Mink; D008517:Phytotherapy; D030021:Pinellia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D004365:Drugs, Chinese Herbal