Co-infection of Mycobacterium tuberculosis and Mycobacterium leprae in human archaeological samples: a possible explanation for the historical decline of leprosy.
Both leprosy and tuberculosis were prevalent in Europe during the first millennium but thereafter leprosy declined. It is not known why this occurred, but one suggestion is that cross-immunity protected tuberculosis patients from leprosy. To investigate any relationship between the two diseases, selected archaeological samples, dating from the Roman period to the thirteenth century, were examined for both Mycobacterium leprae and Mycobacterium tuberculosis DNA, using PCR. The work was carried out and verified in geographically separate and independent laboratories. Several specimens with palaeopathological signs of leprosy were found to contain DNA from both pathogens, indicating that these diseases coexisted in the past. We suggest that the immunological changes found in multi-bacillary leprosy, in association with the socio-economic impact on those suffering from the disease, led to increased mortality from tuberculosis and therefore to the historical decline in leprosy.
Donoghue
Helen D
HD
Centre for Infectious Diseases and International Health, Department of Infection, University College London, 46 Cleveland Street, London W1T 4JF, UK. h.donoghue@ucl.ac.uk
Marcsik
Antónia
A
Matheson
Carney
C
Vernon
Kim
K
Nuorala
Emilia
E
Molto
Joseph E
JE
Greenblatt
Charles L
CL
Spigelman
Mark
M
D001842:Bone and Bones / Q000382:microbiology*; D017931:DNA Primers; D004586:Electrophoresis; D005060:Europe; D005580:Fossils; D049690:History, Ancient; D049691:History, Medieval; D006801:Humans; D007918:Leprosy / Q000150:complications / Q000235:genetics* / Q000266:history / Q000276:immunology; D009166:Mycobacterium leprae / Q000235:genetics*; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D021141:Nucleic Acid Amplification Techniques; D010164:Paleopathology; D017422:Sequence Analysis, DNA; D012959:Socioeconomic Factors; D014376:Tuberculosis / Q000150:complications / Q000235:genetics* / Q000276:immunology
D017931:DNA Primers
Tuberculosis (Edinb). 2004;84(1-2):110-30
14670352
FEMS Immunol Med Microbiol. 2001 Jul;31(1):53-8
11476982
J Infect Dis. 1998 Jan;177(1):133-45
9419180
Lepr India. 1979 Jan;51(1):65-73
449287
Lepr India. 1982 Oct;54(4):671-6
7183833
Arch Intern Med. 2003 May 12;163(9):1009-21
12742798
Southeast Asian J Trop Med Public Health. 1995 Jun;26(2):253-7
8629055
J Med Microbiol. 2001 Feb;50(2):177-182
11211226
Lepr Rev. 1998 Dec;69(4):341-50
9927806
Tuber Lung Dis. 1995 Dec;76(6):545-9
8593377
Tubercle. 1991 Mar;72(1):1-6
1882440
Int J Lepr Other Mycobact Dis. 1987 Sep;55(3):510-4
3655465
Vaccine. 2000 Jan 31;18(14):1294-7
10618524
Int J Lepr Other Mycobact Dis. 2001 Jun;69(2):93-8
11757171
Int J Lepr Other Mycobact Dis. 1999 Dec;67(4):460-70
10700922
Science. 1998 Jul 17;281(5375):402-6
9665881
Tubercle. 1984 Jun;65(2):137-53
6380066
Am J Public Health. 1997 Dec;87(12):1923-7
9431277
Clin Infect Dis. 2001 Aug 1;33(3):305-11
11438894
Am J Phys Anthropol. 2000 Mar;111(3):319-31
10685035
Int J Lepr Other Mycobact Dis. 1993 Jun;61(2):199-204
8371028
Thorax. 2002 May;57(5):442-5
11978923
Lancet. 1994 May 28;343(8909):1360-1
7910345
Semin Immunol. 2004 Feb;16(1):35-41
14751762