[Prospective study of families on a genetic cancer registry].
The Familial Cancer Register, Moscow, established in 1990, has a record of pedigrees of 6,000 cancer patients. The records on the probands and families have been studied since 1995. The paper presents the data of a repeat survey of the families conducted in 1990-1995. Only 794 out of 3,000 families, included in the first survey, responded. Relapse was reported in 135 probands and/or relatives from 108 families. The following subgroups were identified depending on the rates of cancer morbidity in familial histories (the criteria are presented): 1) no incidence; 2) few cases; (3) more cases, and (4) all family members have cancer. New tumors were detected in one-third of such families. A direct correlation was found between the morbidity rates and neoplasia incidence. In 12 families of group 3, originally, not all the members had tumors.
Chudina
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AP
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D011446:Prospective Studies; D012042:Registries; D012426:Russia / Q000453:epidemiology