Influence of hormonal stimulation on in vitro fertilization/embryo transfer outcome.
OBJECTIVE
To compare efficacy and efficiency of ovarian stimulation therapy.


METHODS
Retrospective study compares ovarian response as number of retrieved oocytes, fertilization rates, endometrial patterns, number of pregnancies and pregnancy rates to different stimulation protocols.


RESULTS
The least number of cancelled cycles was in long protocols with buserelin. There was no difference in overall number of retrieved oocytes between the rFSH and HMG protocols, but 75% of the patients undergoing both protocols had higher number of oocytes after rFSH. The highest pregnancy rate (35.13%) was with rFSH. There was no statistical correlation between endometrial pattern and type of protocol used. Data showed the 9 mm cut-off value for endometrial thickness, and RI = 0.58 for subendometrial blood flow between the pregnant and non-pregnant group of patients. Nitriderm patches significantly decreased (P < 0.05) subendometrial RI of the patients with impaired uterine perfusion, increased endometrial thickness and achieved better morphology.


CONCLUSIONS
These findings demonstrate that rFSH alone and in long protocol gives better results in wide patient population. Nitriderm patches seem to have good impact on pregnancy rate, but further studies are necessary before making any statements.
Bauman
Renato
R
Clinical Laboratory for Human Reproduction, Department of Obstetrics and Gynecology, Medical School, University of Zagreb, Sveti Duh Hospital, Sveti Duh 64, 10000 Zagreb, Croatia, Europe.
Vujisic
Sanja
S
Tripalo
Ana
A
Aksamija
Alenka
A
Hafner
Daria
D
Emedi
Ivana
I
Kupesic
Sanja
S
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000628:therapy; D007247:Infertility, Female / Q000628:therapy*; D007248:Infertility, Male / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome; D014591:Uterine Diseases / Q000188:drug therapy; D014599:Uterus / Q000098:blood supply