Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion.
Specific adhesion among like cells is a key determinant of the architecture of tissues. Homophilic (like binds like) adhesive interactions between cells are mediated by cadherins. These integral membrane glycoproteins have a crucial role in tissue morphogenesis during development and the maintenance of tissue integrity in adults. There is also an increasing recognition of a regulatory role for cadherins in a variety of cell functions, including cell migration. The recent identification of cadherin-11 expression in fibroblast-like synoviocytes (FLSs) has shed light on the mechanisms of synovial tissue organization and differentiation. Moreover, cadherin-11 expression in FLSs might also provide insight into pathways that determine the mesenchymal tissue response of the synovium to inflammation.
Kiener
Hans P
HP
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Brenner
Michael B
MB
D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000473:pathology; D015820:Cadherins / Q000145:classification / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation; D006801:Humans; D006965:Hyperplasia; D008648:Mesoderm / Q000473:pathology; D009024:Morphogenesis; D009369:Neoplasms / Q000473:pathology; D011993:Recombinant Fusion Proteins / Q000502:physiology; D013583:Synovial Membrane / Q000378:metabolism* / Q000648:ultrastructure; D014162:Transfection
D015820:Cadherins; D011993:Recombinant Fusion Proteins; C086960:osteoblast cadherin
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