title: Effect of acute hyperinsulinemia on ventricular repolarization in uncomplicated obesity.
abstract: BACKGROUND
  Acute hyperinsulinemia has been shown to increase QTc interval in lean subjects, but data on obese subjects are still unclear. Aim of this study was to evaluate the effect of acute hyperinsulinemia on QTc interval and QTc dispersion in uncomplicated obesity.
  
  
  METHODS
  We calculated QTc duration and QTc dispersion in 30 uncomplicated obese subjects (mean age 32.2 +/- 7, BMI 36.7 +/- 9.4 kg/m(2)) by measurements of 12-lead ECG recording during a euglycemic hyperinsulinemic clamp.
  
  
  RESULTS
  Insulin infusion during the clamp did not significantly modify QTc interval and QTc dispersion in uncomplicated obese subjects (401.5 +/- 29.2 vs. 413.7 +/- 30.5; 35.4 +/- 10.5 vs. 38.7 +/- 14.5, respectively).
  
  
  CONCLUSIONS
  Acute hyperinsulinemia seems to no significantly affect ventricular repolarization in uncomplicated obesity. Insulin resistance and the absence of diabetes and hypertension could explain, at least in part, this finding.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Iacobellis
authors.forename: Mario
authors.initials: M
authors.lastname: Curione
authors.forename: Simonetta
authors.initials: S
authors.lastname: Di Bona
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Ribaudo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Zappaterreno
authors.forename: Elio
authors.initials: E
authors.lastname: Vecci
authors.forename: Umberto
authors.initials: U
authors.lastname: Di Mario
authors.forename: Frida
authors.initials: F
authors.lastname: Leonetti
mesh_terms: D000208:Acute Disease; D000328:Adult; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000503:physiopathology*; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D016276:Ventricular Function