title: iPF2alpha-III-17,18,19,20-d4: total synthesis and metabolism.
abstract: The first total synthesis of 17,18,19,20-d4-iPF2alpha-III 32, a deuterated analog of iPF2alpha-III, is described. We have used this analog in some beta-oxidation studies with rat liver homogenates and have shown that 32 was metabolized to 17,18,19,20-tetradeutero-2,3-dinor-iPF2alpha-III 36 and 17,18,19,20-tetradeutero-2,3-dinor-5,6-dihydro-iPF2alpha-III 37.
authors.affiliation: Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 West University Boulevard, Melbourne, FL 32901, USA.
authors.forename: Seongjin
authors.initials: S
authors.lastname: Kim
authors.forename: William S
authors.initials: WS
authors.lastname: Powell
authors.forename: John A
authors.initials: JA
authors.lastname: Lawson
authors.forename: Sheila H
authors.initials: SH
authors.lastname: Jacobo
authors.forename: Domenico
authors.initials: D
authors.lastname: Pratico
authors.forename: Garret A
authors.initials: GA
authors.lastname: FitzGerald
authors.forename: Kirk
authors.initials: K
authors.lastname: Maxey
authors.forename: Joshua
authors.initials: J
authors.lastname: Rokach
mesh_terms: D000818:Animals; D003903:Deuterium; D066298:In Vitro Techniques; D028421:Isoprostanes / Q000737:chemistry* / Q000378:metabolism*; D007553:Isotope Labeling; D008099:Liver / Q000201:enzymology; D015394:Molecular Structure; D051381:Rats
chemical_list: D028421:Isoprostanes; C438786:isoprostane F2alpha III; D003903:Deuterium