[Study on the analysis of organogermanium compounds by ion chromatography].
A new high performance ion exchange chromatographic method for separation and determination of three organogermanium compounds beta-carboxyethylgermanium sesquioxide (I), beta-(alpha-methyl) carboxyethylgermanium sesquioxide (II) and di-(beta-carboxyethyl) germanium hydroxide (III) has been developed. A Dionex DX-300 Ion Chromatograph equipped with a Dionex PED-II pulsed electrochemical detector (conductivity mode), a Dionex AMMS-1 anion micromembrane suppressor, and a Dionex ACI advanced computer interface coupled with AI-450 chromatographic software was employed. The separation was achieved by using a Dionex IonPac AS4A-SC column as analytical column, sodium tetraborate solution as eluent, and sulfuric acid solution as regenerant. For reducing run time, a gradient program was chosen. The detection limits (S/N = 3, expressed as germanium) for the three compounds were 0.038mg/L (I), 0.035mg/L (II) and 0.025mg/L (III), respectively. The method has been applied to the analysis of two tonic oral drinks, and the average recoveries for the three compounds ranged from 95%-101%. The results obtained were in agreement with those of hydride generation atomic fluorescence spectrometry (HG-AFS).
Chen
Q
Q
Research Center for Eco-Environmental Sciences, the Chinese Academy of Sciences, Beijing, 100085.
Mou
S
S
Hou
X
X
Ni
Z
Z
D002852:Chromatography, Ion Exchange / Q000379:methods*; D005857:Germanium / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012680:Sensitivity and Specificity
D004364:Pharmaceutical Preparations; D005857:Germanium