The relationship between refractive and biometric changes during Edinger-Westphal stimulated accommodation in rhesus monkeys.
Experiments were undertaken to understand the relationship between dynamic accommodative refractive and biometric (lens thickness (LT), anterior chamber depth (ACD) and anterior segment length (ASL=ACD+LT)) changes during Edinger-Westphal stimulated accommodation in rhesus monkeys. Experiments were conducted on three rhesus monkeys (aged 11.5, 4.75 and 4.75 years) which had undergone prior, bilateral, complete iridectomies and implantation of a stimulating electrode in the Edinger-Westphal (EW) nucleus. Accommodative refractive responses were first measured dynamically with video-based infrared photorefraction and then ocular biometric responses were measured dynamically with continuous ultrasound biometry (CUB) during EW stimulation. The same stimulus amplitudes were used for the refractive and biometric measurements to allow them to be compared. Main sequence relationships (ratio of peak velocity to amplitude) were calculated. Dynamic accommodative refractive changes are linearly correlated with the biometric changes and accommodative biometric changes in ACD, ASL and LT show systematic linear correlations with increasing accommodative amplitudes. The relationships are relatively similar for the eyes of the different monkeys. Dynamic analysis showed that main sequence relationships for both biometry and refraction are linear. Although accommodative refractive changes in the eye occur primarily due to changes in lens surface curvature, the refractive changes are well correlated with A-scan measured accommodative biometric changes. Accommodative changes in ACD, LT and ASL are all well correlated over the full extent of the accommodative response.
Vilupuru
Abhiram S
AS
College of Optometry, University of Houston, 4901 Calhoun Rd, Houston, TX 77204-6052, USA.
Glasser
Adrian
A
D000065:Accommodation, Ocular / Q000502:physiology*; D000818:Animals; D000867:Anterior Chamber / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D004558:Electric Stimulation / Q000379:methods; D007908:Lens, Crystalline / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D008253:Macaca mulatta; D012029:Refraction, Ocular / Q000502:physiology*; D014463:Ultrasonography
Invest Ophthalmol Vis Sci. 1999 May;40(6):1162-9
10235549
Ophthalmology. 1999 May;106(5):863-72
10328382
Vision Res. 2003 Oct;43(22):2363-75
12962993
Trans Am Ophthalmol Soc. 1997;95:261-7; discussion 267-70
9440174
Invest Ophthalmol. 1975 Oct;14(10):766-71
810452
Invest Ophthalmol Vis Sci. 1998 Oct;39(11):2140-7
9761293
J Physiol. 1993 Feb;461:301-20
8350267
Am J Optom Physiol Opt. 1985 Aug;62(8):523-32
4037058
Vision Res. 1993 Jul;33(10):1311-24
8333155
Invest Ophthalmol Vis Sci. 2004 Jan;45(1):215-21
14691176
Invest Ophthalmol Vis Sci. 1993 Mar;34(3):690-4
8449687
Vision Res. 1994 Nov;34(21):2897-905
7975324
Optom Vis Sci. 1989 Dec;66(12):830-3
2626248
Exp Eye Res. 1973 Apr;15(4):441-59
4702379
Vision Res. 2002 Jan;42(1):125-41
11804637
Vision Res. 1998 Jan;38(2):209-29
9536350
Invest Ophthalmol Vis Sci. 1997 Mar;38(3):569-78
9071209
Ophthalmic Physiol Opt. 1983;3(3):315-20
6646767
Vision Res. 1999 Jun;39(11):1991-2015
10343784
Exp Eye Res. 1987 Aug;45(2):317-26
3653294
Brain Res. 1989 Dec 4;503(2):265-72
2605519
Vision Res. 1987;27(7):1139-63
3660666
Vision Res. 1997 Oct;37(19):2789-800
9373677
Vision Res. 1984;24(10):1141-51
6523736
Vision Res. 2003 Dec;43(27):2945-56
14568383
Invest Ophthalmol Vis Sci. 1990 Oct;31(10):2185-90
2211015
Optom Vis Sci. 1994 Apr;71(4):250-3
8047337
Optom Vis Sci. 2003 May;80(5):383-94
12771664
Ophthalmic Physiol Opt. 1997 Jan;17(1):12-7
9135807
J Biomed Eng. 1987 Jan;9(1):32-7
3540452
Invest Ophthalmol Vis Sci. 1990 Dec;31(12):2483-92
2265988
Optom Vis Sci. 1996 Apr;73(4):235-42
8728490
Ophthalmic Physiol Opt. 1996 May;16(3):216-21
8977885
Int Ophthalmol Clin. 2001 Spring;41(2):1-15
11290918