title: The efavirenz-induced increase in HDL-cholesterol is influenced by the multidrug resistance gene 1 C3435T polymorphism.
abstract: Efavirenz treatment has been associated with increases in HDL-cholesterol concentrations, and the circulating levels of the drug have been related to the multidrug resistance gene 1 (MDR-1) C3435T polymorphism. The changes in the measured lipid parameters were evaluated in 59 HIV-infected patients initiating efavirenz-based treatment at baseline and at 12 months of follow-up. Efavirenz treatment increased HDL-cholesterol. The changes in concentrations appeared to be influenced by the MDR-1 gene polymorphism, in which CC > CT > TT.
authors.affiliation: Servei de Medicina Interna, Hospital Universitari de Sant Joan, Reus, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Alonso-Villaverde
authors.forename: Blai
authors.initials: B
authors.lastname: Coll
authors.forename: Federico
authors.initials: F
authors.lastname: Gómez
authors.forename: Sandra
authors.initials: S
authors.lastname: Parra
authors.forename: Jordi
authors.initials: J
authors.lastname: Camps
authors.forename: Jorge
authors.initials: J
authors.lastname: Joven
authors.forename: Lluis
authors.initials: L
authors.lastname: Masana
mesh_terms: D000328:Adult; D000480:Alkynes; D019380:Anti-HIV Agents / Q000009:adverse effects*; D048588:Benzoxazines; D008076:Cholesterol, HDL / Q000097:blood*; D003521:Cyclopropanes; D005260:Female; D005500:Follow-Up Studies; D019450:Genes, MDR / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010078:Oxazines / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D008076:Cholesterol, HDL; D003521:Cyclopropanes; D010078:Oxazines; D018894:Reverse Transcriptase Inhibitors; C098320:efavirenz