[The oxidative stress in platelets of patients with ovary cancer as observed at chemotherapy].
Disorders in the main chains of platelet antioxidant protection were examined in 32 patients with primarily-diagnosed ovary cancer who were postoperatively receiving chemotherapy according to PC. The activity of antioxidant-protection enzymes (superoxide dismutase, catalase, glutation-S-transferase) as well as the content of malonic dialdehyde (MDA) and glutathione were examined after each course of chemotherapy. The data obtained were compared with the aggregation ability of platelets, with the content of fibrinogen and with the count of platelets. The parameters of the antioxidant system in platelets were examined for control in 30 virtually healthy women. The results denote that the oxidant stress progression in the body due to the growing tumor and aggravating because of chemodrugs deregulates the free-radical processes in platelets, which can affect their functional properties or rheological blood properties.
Zubrikhina
G N
GN
Davydova
T V
TV
Kormosh
N G
NG
Gorozhanskaia
E G
EG
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D010051:Ovarian Neoplasms / Q000097:blood* / Q000188:drug therapy; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010088:Oxidoreductases / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count
D000970:Antineoplastic Agents; D008315:Malondialdehyde; D010088:Oxidoreductases