High specificity of myositis specific autoantibodies for myositis compared with other neuromuscular disorders.
Myositis specific autoantibodies (MSAs) are proven to be specific for myositis compared with other inflammatory connective tissue diseases. Their specificity compared, however, with other neuromuscular disorders, which are included in the differential diagnosis of patients in whom the diagnosis myositis is under consideration, is unknown. We prospectively screened sera from 107 patients with various neuromuscular disorders for the most common MSAs and compared the results with the findings in a group of 97 myositis patients, published previously. Special attention was paid to patients with facioscapulohumeral muscular dystrophy (FSHD), an autosomal dominant muscle disease with marked inflammation in skeletal muscle tissue. Only one patient in the neuromuscular disorders group tested positive for an MSA, compared with 41 in the myositis group, resulting in a specificity of 99%. None of the FSHD patients tested positive. We conclude that the tested MSAs are highly specific for myositis and that they are not merely associated with muscle inflammation.
Hengstman
G J D
GJ
Neuromuscular Centre Nijmegen, Dept. of Neurology, University Medical Centre Nijmegen, 9101, 6500 HB, Nijmegen, The Netherlands. g.hengstman@neuro.umcn.nl
van Brenk
L
L
Vree Egberts
W T M
WT
van der Kooi
E L
EL
Borm
G F
GF
Padberg
G W A M
GW
van Venrooij
W J
WJ
van Engelen
B G M
BG
D001323:Autoantibodies / Q000097:blood*; D016001:Confidence Intervals; D006801:Humans; D009220:Myositis / Q000097:blood*; D009468:Neuromuscular Diseases / Q000097:blood; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D001323:Autoantibodies
J Neurol. 2002 Jan;249(1):69-75
11954871
Lancet. 2003 Sep 20;362(9388):971-82
14511932
Arthritis Rheum. 1996 Feb;39(2):292-6
8849382
Muscle Nerve Suppl. 1995;2:S56-66
7739627
Arthritis Rheum. 2004 Jan;50(1):209-15
14730618
Semin Arthritis Rheum. 1996 Aug;26(1):459-67
8870113
Ann Rheum Dis. 2001 Feb;60(2):116-23
11156543
Arthritis Rheum. 1998 Aug;41(8):1428-37
9704641
Medicine (Baltimore). 1991 Nov;70(6):360-74
1659647
Eur Arch Psychiatry Clin Neurosci. 1991;241(2):105-8
1834179
J Rheumatol. 1995 Apr;22(4):668-74
7791161
Clin Exp Immunol. 1997 Jul;109(1):32-40
9218821
Proc Natl Acad Sci U S A. 1990 Dec;87(24):9933-7
1702223
Arthritis Rheum. 1992 Apr;35(4):449-56
1567494
Curr Opin Rheumatol. 2001 Nov;13(6):476-82
11698723