title: Does Down syndrome affect the long-term results of complete atrioventricular septal defect when the defect is repaired during the first year of life?
abstract: BACKGROUND
  Down syndrome is known to affect the natural history of complete atrioventricular septal defect. We analyzed whether Down syndrome affect the long-term results of complete atrioventricular septal defect when the defect is repaired during the first year of life.
  
  
  METHODS
  Repairs of complete atrioventricular septal defect were performed in 64 infants. Thirty-four infants were associated with Down syndrome, while the other 30 were non-Down patients.
  
  
  RESULTS
  Complete follow-up rate was 95% with mean follow-up period of 99+/-47 months (maximum 169 months) in Down patients and 80+/-64 months (maximum 213 months) in non-Down patients. There was one operative death in each group (mortality rate of 2.9% in Down patients and 3.3% in non-Down patients), and three patients died at the late phase (one in Down patients and two in non-Down patients). Five patients underwent re-operation due to postoperative left atrioventricular valve regurgitation (one in Down patients and four in non-Down patients). Freedom from re-operation for left atrioventricular valve regurgitation and actuarial survival rate at 13 years were 96+/-4 and 94+/-4% in Down patients and 85+/-7 and 90+/-5% in non-Down patients (not significantly different).
  
  
  CONCLUSIONS
  Down syndrome does not affect the long-term results of complete atrioventricular septal defect when the defect is repaired during the first year of life.
authors.affiliation: Department of Cardiovascular Surgery, Kyushu University Hospital, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. masudam@heart.med.kyushu-u.ac.jp
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kado
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Tanoue
authors.forename: Koji
authors.initials: K
authors.lastname: Fukae
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Onzuka
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Shiokawa
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Shirota
authors.forename: Hisataka
authors.initials: H
authors.lastname: Yasui
mesh_terms: D000367:Age Factors; D004314:Down Syndrome / Q000601:surgery*; D004812:Epidemiologic Methods; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000601:surgery*; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D012086:Reoperation; D016896:Treatment Outcome; D014262:Tricuspid Valve Insufficiency / Q000601:surgery