title: Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats.
abstract: The aim of this study was to examine whether bovine colostrum was able to prevent the NSAID induced small intestinal damage in animals. The animal model population of the study consisted of 4 groups: control group, diclofenac group, diclofenac with 10% low fat milk group and diclofenac with 5% colostrum group. The animals with milk or colostrum were fed with 10% low fat milk or 5% colostral solution for 5 days before the administration of diclofenac. Gut injuries were induced by administration of a single dose of diclofenac (100 mg/kg orally). Epithelial permeability values (24 hour urinary excretion of 51Cr-ethylenediaminetetraacetic acid [51Cr-EDTA]), enteric aerobic bacterial counts, serum biochemical profiles and pathologic findings of distal ileum were measured. Diclofenac caused a marked increase in the intestinal permeability, enteric bacterial numbers and intestinal villous damage, and enteric protein and albumin loss. Combined administration of bovine colostrum reduced the increase in intestinal permeability, enteric bacterial overgrowth, protein losing enteropathy and mucosal villous damage of the small intestine induced by diclofenac. Bovine colostrum may have a beneficial effect in prevention of NSAID induced small intestinal injuries.
authors.affiliation: Departments of Internal Medicine, Kangbuk Samsung Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jeonwk@samsung.co.kr
authors.forename: Jeong Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Woo Kyu
authors.initials: WK
authors.lastname: Jeon
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Yun
authors.forename: Dong Il
authors.initials: DI
authors.lastname: Park
authors.forename: Yong Kyun
authors.initials: YK
authors.lastname: Cho
authors.forename: In Kyung
authors.initials: IK
authors.lastname: Sung
authors.forename: Chung Il
authors.initials: CI
authors.lastname: Sohn
authors.forename: Byung Ik
authors.initials: BI
authors.lastname: Kim
authors.forename: Joon Sup
authors.initials: JS
authors.lastname: Yeom
authors.forename: Hyo Soon
authors.initials: HS
authors.lastname: Park
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Kim
authors.forename: Myong Suk
authors.initials: MS
authors.lastname: Shin
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002417:Cattle; D003126:Colostrum; D004008:Diclofenac / Q000009:adverse effects*; D005260:Female; D007082:Ileum / Q000187:drug effects / Q000382:microbiology / Q000502:physiology; D007410:Intestinal Diseases / Q000139:chemically induced / Q000382:microbiology / Q000517:prevention & control*; D008297:Male; D023421:Models, Animal; D010539:Permeability / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac