Effectiveness and safety of the thrombolytic therapy for acute pulmonary thromboembolism: results of a multicenter registry in the Japanese Society of Pulmonary Embolism Research.
OBJECTIVE
To assess the effectiveness and safety of thrombolytic treatment for acute pulmonary thromboembolism (APTE), especially in the hemodynamically stable patients with right ventricular afterload stress.


RESULTS
In a total of 221 patients with APTE, the association between thrombolytic treatment and the clinical outcomes were investigated. Thrombolysis was given to 121 patients (Thrombolytic Group), and the remaining 100 patients were treated with anticoagulation alone (Anticoagulation Group). In both patients with prolonged shock and patients who were hemodynamically stable without right ventricular afterload stress, the rate of death and recurrence of APTE in Anticoagulation Group were similar to those in Thrombolytic Group. In patients with right ventricular afterload stress, better outcomes were observed in Thrombolytic Group than in Anticoagulation Group, although the difference did not reach statistical significance. There was no significant difference in the rate of major bleeding episode between these two groups.


CONCLUSIONS
Our results suggested that performing thrombolytic treatment in APTE patients with right ventricular afterload stress should be considered even in Japan.
Nakamura
Mashio
M
The First Department of Internal Medicine, Mie University, Edobashi 2-147, Tsu 514-8507, Japan. mashio@clin.mie-u.ac.jp
Nakanishi
Norifumi
N
Yamada
Norikazu
N
Sakuma
Masahito
M
Miyahara
Yoshiyuki
Y
Okada
Osamu
O
Tanabe
Nobuhiro
N
Kuriyama
Takayuki
T
Kunieda
Takeyoshi
T
Shirato
Kunio
K
Sugimoto
Tsuneaki
T
Nakano
Takeshi
T
D000208:Acute Disease; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000188:drug therapy*; D012042:Registries; D012189:Retrospective Studies; D015912:Thrombolytic Therapy