Efg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicans.
The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1/cph1 efg1/efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3. Mutations in EFG1 consistently increased the susceptibility of the cells to antifungal agents.
Lo
Hsiu-Jung
HJ
Division of Clinical Research, National Health Research Institutes, Taipei, Taiwan, Republic of China.
Wang
Jang-Shiun
JS
Lin
Chih-Yang
CY
Chen
Chia-Geun
CG
Hsiao
Ting-Yin
TY
Hsu
Chia-Tung
CT
Su
Chia-Li
CL
Fann
Ming-Ji
MJ
Ching
Yu-Tai
YT
Yang
Yun-Liang
YL
D002176:Candida albicans / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D004268:DNA-Binding Proteins / Q000502:physiology*; D025141:Drug Resistance, Fungal; D005656:Fungal Proteins / Q000502:physiology*; D015966:Gene Expression Regulation, Fungal; D010088:Oxidoreductases / Q000235:genetics*; D014157:Transcription Factors / Q000502:physiology*; D014774:Virulence
D004268:DNA-Binding Proteins; C121438:EFG1 protein, Candida albicans; D005656:Fungal Proteins; D014157:Transcription Factors; D010088:Oxidoreductases; C039306:sterol delta-5 desaturase
Microbiology. 1999 Oct;145 ( Pt 10):2701-13
10537192
Methods Enzymol. 1999;303:349-80
10349654
Trends Mol Med. 2002 Feb;8(2):76-81
11815273
Mol Microbiol. 2003 May;48(4):959-76
12753189
Rev Med Chil. 2003 Mar;131(3):299-302
12790079
Antimicrob Agents Chemother. 2003 Aug;47(8):2404-12
12878497
Mol Gen Genet. 1984;198(2):179-82
6394964
J Med Vet Mycol. 1994;32 Suppl 1:189-202
7722785
Antimicrob Agents Chemother. 1997 Jan;41(1):196-9
8980781
J Biol Chem. 1997 Feb 28;272(9):5682-8
9038178
Antimicrob Agents Chemother. 1997 Jul;41(7):1488-94
9210671
Cell. 1997 Sep 5;90(5):939-49
9298905
Antimicrob Agents Chemother. 1998 Feb;42(2):241-53
9527767
Clin Microbiol Rev. 1998 Apr;11(2):382-402
9564569
Antimicrob Agents Chemother. 2000 Mar;44(3):747-51
10681349