Dual treatment of albendazole in hepatic hydatidosis: New therapeutic modality in 52 cases.
BACKGROUND
Hepatic hydatidosis still remains as a serious problem in general surgery. Recurrence and/or secondary hydatidosis rates are up to 25% in the cases treated with surgery alone. Albendazole is the most commonly used drug in the medical treatment of echinococcosis. The aim of the present study was to evaluate the effect of albendazole using the intraoperative and perioperative periods as dual therapy.


METHODS
Fifty-two cases of hepatic hydatidosis were evaluated and treated by dual treatment of albendazole together with surgery. Perioperative albendazole treatment was given in a dose of 12-15 mg/kg per day in four divided doses. The treatment started 2-28 days before the surgery when the diagnosis was established and continued for 2-24 months (4.76 +/- 3.25) postoperatively in a cyclic monthly form. A total of 1.7 microg/mL albendazole solution was used as a protoscolicidal agent in the cystic cavity intraoperatively. In the postoperative period serology, ultrasonography and computed tomography evaluations were done. The follow-up period was 5-92 months (mean: 62.48 months).


RESULTS
There was no recurrence in the present study. One patient died in the 6th postoperative week due to cerebral hydatidosis and multiple organ failure. Early and late morbidity rates were 7.69 and 9.61%, respectively.


CONCLUSIONS
Dual albendazole treatment is effective in the prevention of recurrences and/or secondary hydatidosis.
Polat
Cafer
C
Department of General Surgery, Ondokuz Mayis University, Medical School, Kurupelit, Samsun, Turkey. caferpolat@omu.edu.tr
Dervisoglu
Adem
A
Hokelek
Murat
M
Yetim
Ibrahim
I
Buyukkarabacak
Yalcin
Y
Ozkutuk
Yasin
Y
Erzurumlu
Kenan
K
D000328:Adult; D000368:Aged; D015766:Albendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D000923:Anticestodal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004333:Drug Administration Routes; D004444:Echinococcosis, Hepatic / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007432:Intraoperative Period; D010535:Laparoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D011184:Postoperative Period; D012189:Retrospective Studies; D013396:Suction; D016896:Treatment Outcome; D014741:Video Recording
D000923:Anticestodal Agents; D015766:Albendazole