title: Lambda interferon inhibits hepatitis B and C virus replication.
abstract: Lambda interferon (IFN-lambda) induces an intracellular IFN-alpha/beta-like antiviral response through a receptor complex distinct from the IFN-alpha/beta receptor. We therefore determined the ability of IFN-lambda to inhibit hepatitis B virus (HBV) and hepatitis C virus (HCV) replication. IFN-lambda inhibits HBV replication in a differentiated murine hepatocyte cell line with kinetics and efficiency similar to IFN-alpha/beta and does not require the expression of IFN-alpha/beta or IFN-gamma. Furthermore, IFN-lambda blocked the replication of a subgenomic and a full-length genomic HCV replicon in human hepatocyte Huh7 cells. These results suggest the possibility that IFN-lambda may be therapeutically useful in the treatment of chronic HBV or HCV infection.
authors.affiliation: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA. michael.robek@yale.edu
authors.forename: Michael D
authors.initials: MD
authors.lastname: Robek
authors.forename: Bryan S
authors.initials: BS
authors.lastname: Boyd
authors.forename: Francis V
authors.initials: FV
authors.lastname: Chisari
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002478:Cells, Cultured; D016174:Hepacivirus / Q000187:drug effects / Q000502:physiology*; D006515:Hepatitis B virus / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D007372:Interferons
references.citation: J Virol. 2000 May;74(9):4165-73
references.pmid: 10756029
references.citation: Curr Opin Microbiol. 1999 Aug;2(4):388-91
references.pmid: 10490351
references.citation: J Gen Virol. 2001 Apr;82(Pt 4):723-33
references.pmid: 11257176
references.citation: J Virol. 2001 Sep;75(18):8516-23
references.pmid: 11507197
references.citation: Hepatology. 2002 Mar;35(3):694-703
references.pmid: 11870386
references.citation: J Virol. 2002 Apr;76(7):3570-4
references.pmid: 11884582
references.citation: J Virol. 2002 Apr;76(8):4008-21
references.pmid: 11907240
references.citation: J Virol. 2002 Jun;76(11):5646-53
references.pmid: 11991993
references.citation: J Virol. 2002 Nov;76(21):11148-54
references.pmid: 12368359
references.citation: Nat Immunol. 2003 Jan;4(1):63-8
references.pmid: 12469119
references.citation: Nat Immunol. 2003 Jan;4(1):69-77
references.pmid: 12483210
references.citation: J Virol. 2003 Jan;77(2):1092-104
references.pmid: 12502825
references.citation: Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1310-5
references.pmid: 12552098
references.citation: Eur J Immunol. 2004 Mar;34(3):796-805
references.pmid: 14991609
references.citation: N Engl J Med. 2004 Mar 11;350(11):1118-29
references.pmid: 15014185
references.citation: J Leukoc Biol. 2004 Aug;76(2):314-21
references.pmid: 15123776
references.citation: Nature. 1979 Jun 7;279(5713):523-5
references.pmid: 571963
references.citation: Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12398-402
references.pmid: 8618909
references.citation: Arch Biochem Biophys. 1996 Jun 15;330(2):290-300
references.pmid: 8660659
references.citation: Science. 2000 Dec 8;290(5498):1972-4
references.pmid: 11110665