title: Quality of life during pollen season in patients with seasonal allergic rhinitis with or without asthma.
abstract: OBJECTIVE
  We studied the evolution of generic and rhinoconjunctivitis-specific quality of life (QOL) during pollen season in patients with isolated seasonal allergic rhinitis (SAR) and those with asthma and concomitant SAR (AS+SAR). Generic QOL between groups was also compared at pollen peak.
  
  
  METHODS
  A prospective cohort study was conducted in Southern France in 2002. Outpatients aged 18-60, regularly visiting respiratory physicians for SAR, were recruited before the grass (grass cohort) or ragweed pollination period (ragweed cohort). Before the pollination period (baseline) and at peak pollination, patients completed French versions of the Mini Rhinoconjuctivitis Quality of Life Questionnaire (Mini-RQLQ) and physical and mental Short Form-12 (SF-12) scores (PCS and MCS) to determine rhinoconjunctivitis and generic QOL.
  
  
  RESULTS
  Totals of 83 and 52 patients were included in the SAR and AS+SAR groups, respectively (mean age=35.4; 56.4% females). Mini-RQLQ scores indicated slightly worse QOL in the A+SAR group at inclusion, which significantly deteriorated at the time of pollen peak, both in the SAR (p<0.0001) and AS+SAR groups (p=0.003). In univariate analysis, significantly higher SF-12 PCS (meaning better QOL) were observed at pollen peak in the SAR compared with the AS+SAR group (p=0.0008), while the difference for SF-12 MCS was more limited (p=0.05). Results were confirmed in multivariable analyses adjusting for gender, allergy medication use at pollen peak, cohort of inclusion (grass/ragweed) and comorbid conditions.
  
  
  CONCLUSIONS
  Significant deterioration in rhinoconjunctivitis-specific QOL was observed through the pollination period in patients with SAR and AS+SAR. At pollen peak, AS+SAR patients experienced significantly worse physical functioning than patients with SAR alone.
authors.affiliation: Pharmacoepidemiology Unit, EA3091 CHU Lyon-Sud, Pierre-Bénite, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Laforest
authors.forename: Jean
authors.initials: J
authors.lastname: Bousquet
authors.forename: Guilhem
authors.initials: G
authors.lastname: Pietri
authors.forename: Vasilisa
authors.initials: V
authors.lastname: Sazonov Kocevar
authors.forename: Donald
authors.initials: D
authors.lastname: Yin
authors.forename: Yves
authors.initials: Y
authors.lastname: Pacheco
authors.forename: Eric
authors.initials: E
authors.lastname: Van Ganse
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D031164:Ambrosia; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005602:France / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D006109:Poaceae; D011058:Pollen / Q000276:immunology*; D011446:Prospective Studies; D011788:Quality of Life; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000453:epidemiology*
chemical_list: D000485:Allergens