Simultaneous tumour-like, atypical basal cell hyperplasia and acinar adenocarcinoma of the prostate: a comparative morphological and genetic approach.
Basal cell tumours of the prostatic gland are rare, and the classification is difficult. In the present case report, a large, tumour-like proliferation of atypical basaloid cells was found incidentally in a prostatectomy specimen that otherwise contained a conventional acinar adenocarcinoma. The basaloid cells displayed a solid or adenoid-cystic growth pattern and strongly expressed high-molecular-weight cytokeratins and bcl-2. A high Ki-67 index was recorded within the atypical basaloid cells, by far exceeding the one counted in the conventional adenocarcinoma. However, there were no definite criteria for a malignant behaviour of the basal cell tumour. Comparative genomic hybridisation from microdissected tumour cells yielded losses at the short arms of chromosomes 8 and 12 in the conventional adenocarcinoma and a normal karyotype in the basal cell tumour. The pathological findings favoured the diagnosis of an atypical basal cell hyperplasia.
Luebke
A M
AM
Department of Urology, University of Hamburg, Martinistrasse 52, 22081 Hamburg, Germany.
Schlomm
T
T
Gunawan
B
B
Bonkhoff
H
H
Füzesi
L
L
Erbersdobler
A
A
D018267:Carcinoma, Acinar Cell / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018295:Neoplasms, Basal Cell / Q000235:genetics / Q000473:pathology; D009693:Nucleic Acid Hybridization; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology*
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