title: Warty squamous cell carcinoma of the vulva in older women: association with human papillomavirus.
abstract: Warty squamous cell carcinoma (WSCC), a rare variant of squamous cell carcinoma occurring in younger women, is primarily associated with human papillomavirus (HPV) infection. Although WSCC appears to exhibit less aggressive behavior than typical well-differentiated squamous cell carcinoma, it bears the risk of regional metastasis. Accordingly, WSCC should be differentiated from other verruciform neoplasms. We describe a rare case of WSCC with a short disease duration occurring in a woman of old age. We found the presence of HPV DNA different from other well-known types of high risk and low risk HPV by DNA chip microarray. These results suggest that various types of HPV can be associated with the pathogenesis of WSCC.
authors.affiliation: Department of Dermatology, Ajou University School of Medicine, San 5, Wonchon-dong, Yeongtong-gu, Suwon 443-721, Korea.
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Jang
authors.forename: You Chan
authors.initials: YC
authors.lastname: Kim
authors.forename: Eun-So
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications* / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000821:virology*; D014846:Vulvar Neoplasms / Q000473:pathology / Q000821:virology*
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