title: Factors characterizing Staphylococcus epidermidis invasiveness determined by comparative genomics.
abstract: Virulence mechanisms of the leading nosocomial pathogen Staphylococcus epidermidis are poorly understood. We used microarray-based genome-wide comparison of clinical and commensal S. epidermidis strains to identify putative virulence determinants. Our study revealed high genetic variability of the S. epidermidis genome, new markers for invasiveness of S. epidermidis, and potential targets for drug development against S. epidermidis infections.
authors.affiliation: Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, MT 59840, USA.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Yao
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Sturdevant
authors.forename: Amer
authors.initials: A
authors.lastname: Villaruz
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
authors.forename: Michael
authors.initials: M
authors.lastname: Otto
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D023281:Genomics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D016459:Prosthesis-Related Infections / Q000382:microbiology; D012867:Skin / Q000382:microbiology; D013203:Staphylococcal Infections / Q000382:microbiology; D013212:Staphylococcus epidermidis / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins
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