[Effect of low dose of gamma-radiation on the cellular content in the center of chronic inflammation].
On the model of chronic aseptic carrageenan-induced inflammation in rats it is shown that low dose-rate y-radiation of small dose (0.1 Gy) leads to the increase of fibroblast and macrophage proliferation in the inflammatory focus, and produces considerable decrease of lymphocyte emigration at all investigated radiation doses. Obtained data on stimulation of proliferation in the inflammatory focus with possible accumulation of DNA errors at depressed immunological supervision by lymphocytes can indirectly point to probability of oncogenous potential increase in the chronic inflammatory focus at low dose-rate gamma-irradiation.
Klymenko
M O
MO
Onyshchenko
M I
MI
D000818:Animals; D002351:Carrageenan / Q000008:administration & dosage; D049109:Cell Proliferation / Q000528:radiation effects*; D002633:Chemotaxis / Q000528:radiation effects; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000528:radiation effects; D005720:Gamma Rays / Q000009:adverse effects*; D007249:Inflammation / Q000473:pathology*; D008214:Lymphocytes / Q000528:radiation effects; D008264:Macrophages / Q000528:radiation effects; D008297:Male; D011829:Radiation Dosage; D051381:Rats; D017208:Rats, Wistar
D002351:Carrageenan