Antimutagenicity of selenium-enriched rice on mice exposure to cyclophosphamide and mitomycin C.
The in vivo antimutagenicity of Se-enriched rice was evaluated by bone marrow micronucleus and testicle chromosomal aberrations assay in mice exposed to cyclophosphamide (CP) and mitomycin C (MMC). Regular rice did not alter the occurrence of chemical-induced mutation. However, the addition of Se-enriched rice or selenite significantly inhibited the incidence of CP-induced micronuclei and MMC-induced chromosomal aberration in mice and the effect was dose-dependent. Providing selenite or Se-enriched rice also significantly increased the activity of glutathione peroxidase in liver and the selenium concentration in blood compared to regular rice. No significant differences were found in mice body weight gain. These results revealed the antimutagenic potential of Se-enriched rice against chemical-induced mutation.
Hu
Qiuhui
Q
Key Laboratory of Food Processing and Quality Control of Agriculture Ministry of China, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People's Republic of China. qiuhuihu@njau.edu.cn
Xu
Juan
J
Chen
Licheng
L
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000633:toxicity*; D004032:Diet; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D016685:Mitomycin / Q000633:toxicity*; D012275:Oryza; D012643:Selenium / Q000494:pharmacology*; D018038:Sodium Selenite / Q000494:pharmacology
D016587:Antimutagenic Agents; D016685:Mitomycin; D003520:Cyclophosphamide; D012643:Selenium; D018038:Sodium Selenite