title: Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infection.
abstract: RNA transcript levels in the syphilis spirochete Treponema pallidum subsp. pallidum (Nichols) isolated from experimentally infected rabbits were determined by the use of DNA microarray technology. This characterization of the T. pallidum transcriptome during experimental infection provides further insight into the importance of gene expression levels for the survival and pathogenesis of this bacterium.
authors.affiliation: Human Genome Sequencing Center, University of Texas-Houston Medical School, Houston, Texas, USA. dsmajs@med.muni.cz
authors.forename: David
authors.initials: D
authors.lastname: Smajs
authors.forename: Matthew
authors.initials: M
authors.lastname: McKevitt
authors.forename: Jerrilyn K
authors.initials: JK
authors.lastname: Howell
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Norris
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Cai
authors.forename: Timothy
authors.initials: T
authors.lastname: Palzkill
authors.forename: George M
authors.initials: GM
authors.lastname: Weinstock
mesh_terms: D000818:Animals; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis; D016366:Open Reading Frames; D012329:RNA, Bacterial; D012333:RNA, Messenger; D011817:Rabbits; D013587:Syphilis / Q000382:microbiology; D014210:Treponema pallidum / Q000235:genetics* / Q000378:metabolism* / Q000472:pathogenicity
chemical_list: D012329:RNA, Bacterial; D012333:RNA, Messenger
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