Isolation and structure elucidation of diazaquinomycin C from a terrestrial Streptomyces sp. and confirmation of the akashin structure.
In the screening of terrestrial Streptomycetes for bioactive components, a new antibiotic designated as diazaquinomycin C (2b) was isolated. The new antibiotic was found to be a homologue of diazaquinomycin A (2a) by spectroscopic methods and by comparison of the NMR data with those of 2a. The same strain additionally produced the akashins 1a-1c. The configuration of the N-O acetale bond in these rare glycosylated dichloroindigo derivatives was confirmed to be beta.
Maskey
R P
RP
Department of Organic Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Grün-Wollny
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I
Laatsch
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H
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D001372:Aza Compounds / Q000737:chemistry / Q000302:isolation & purification*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D011809:Quinones; C497372:diazaquinomycin C; C046688:diazaquinomycin A