title: Is the early development of girls with Rett disorder really normal?
abstract: An apparently normal early development was one of the initial criteria for classical Rett syndrome. However, several investigators considered Rett syndrome to be a developmental disorder manifesting very soon after birth. Videos of 22 Rett cases were assessed carefully for movements, posture, and behavior during the first 6 mo of life. All signs that deviated from the normal standard were recorded meticulously. Special attention was paid to the face, the hands, and body movements. A detailed analysis clearly demonstrated an abnormal quality of general movements (100%), tongue protrusion (62%), postural stiffness (58%), asymmetric eye opening and closing (56%), abnormal finger movements (52%), hand stereotypies (42%), bursts of abnormal facial expressions (42%), bizarre smile (32%), tremor (28%), and stereotyped body movements (15%). Our study is the first to apply specific standardized measures of early spontaneous movements to Rett infants, proving conclusively that the disorder is manifested within the first months of life. Although not necessarily specific, the signs that we have observed will be of value in alerting clinicians to the possibility of the diagnosis at an early stage, when intervention is likely to be most effective.
authors.affiliation: Section Developmental Physiology and Developmental Neurology, Institute of Physiology, Center for Physiological Medecine, Medical University of Graz, A-8010 Graz, Austria. christa.einspieler@meduni-graz.at
authors.forename: Christa
authors.initials: C
authors.lastname: Einspieler
authors.forename: Alison M
authors.initials: AM
authors.lastname: Kerr
authors.forename: Heinz F R
authors.initials: HF
authors.lastname: Prechtl
mesh_terms: D002657:Child Development; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D002658:Developmental Disabilities; D003937:Diagnosis, Differential; D005133:Eye Movements; D005149:Facial Expression; D005260:Female; D006803:Human Development; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051783:Methyl-CpG-Binding Protein 2; D009048:Motor Skills; D010641:Phenotype; D012097:Repressor Proteins / Q000235:genetics; D015518:Rett Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology*; D013239:Stereotyped Behavior; D014741:Video Recording
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; C497392:MECP2 protein, human; D051783:Methyl-CpG-Binding Protein 2; D012097:Repressor Proteins