Expression of p53, p63 and p73 in the orofacial region of human embryos.
We studied p53, p63, p73 protein expression in the orofacial region of five human embryos aged 7-18 weeks of intrauterine development using a three-step immunohistochemical method. Expression of proteins in various locations was evaluated semiquantitatively. A decrease in p53, p63 and p73 proteins occurred in the 13-week-old material with the exception of the tooth germ where a drop in p73 appeared in the ninth week.
Cernochová
Drahomíra
D
Department of Histology and Embryology, Faculty of Medicine, Palacký University, Olomouc, Czech Republic. cernod@tunw.upol.cz
Pospísilová
Eva
E
Kylarová
Dana
D
D004268:DNA-Binding Proteins / Q000032:analysis*; D004622:Embryo, Mammalian / Q000737:chemistry*; D005145:Face / Q000196:embryology*; D016147:Genes, Tumor Suppressor; D006801:Humans; D007150:Immunohistochemistry; D009055:Mouth / Q000196:embryology*; D009687:Nuclear Proteins / Q000032:analysis*; D010750:Phosphoproteins / Q000032:analysis*; D015534:Trans-Activators / Q000032:analysis*; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*; D025521:Tumor Suppressor Proteins
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; C115051:TP63 protein, human; C000606460:TP73 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins