A case of invasive aspergillosis in CGD patient successfully treated with Amphotericin B and INF-gamma.
BACKGROUND
Chronic granulomatous disease (CGD) is a rare disorder of phagocytes in which absence of superoxide and hydrogen peroxide production in phagocytes predisposes patients to bacterial and fungal infections. The most common fungal infections in these patients are caused by Aspergillus species.


METHODS
Here, we describe Aspergillus osteomyelitis of the ribs and hepatic abscess in a 5-year-old boy. The patient was successfully treated with Amphotericin B and INF-gamma.


CONCLUSIONS
With respect to the high frequency of aspergillosis in the CGD patient, immune deficiency should be investigated in patients with invasive aspergillosis. Moreover, using antifungal drugs as prophylaxis can improve the quality of life in these patients.
Mamishi
Setareh
S
Department of Infectious Diseases, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran. smamishi@sina.tums.ac.ir <smamishi@sina.tums.ac.ir>
Zomorodian
Kamiar
K
Saadat
Farshid
F
Gerami-Shoar
Mohsen
M
Tarazooie
Bita
B
Siadati
Seyad Ahmad
SA
D000666:Amphotericin B / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy*; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage*; D008297:Male
D000666:Amphotericin B; D007371:Interferon-gamma
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