[Reaction of alpha-actinin from renal inner medulla on prolonged dehydration].
A western-blot analysis using monoclonal antibodies revealed that a reduction of alpha-actinin occurred in the renal inner medulla under the long-lasting dehydration. The ratio between protein content measured in rats of WAG line being hydrated or after 3-days water deprivation consisted of 52.7+/-6.2 against 23.9+/-3.3 as evaluated in relative units. The alpha-actinin level changes similarly in mutant rats of Brattleboro line not capable of synthesizing vasopressin. It was 57.5+/-4.6 in hydrated animals, and statistically lower in rats being under 3-day water deprivation--26.4+/-5.7 in relative units of protein.
Khegaĭ
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D000185:Actinin / Q000096:biosynthesis*; D000818:Animals; D003681:Dehydration / Q000378:metabolism*; D007679:Kidney Medulla / Q000378:metabolism*; D051381:Rats; D011910:Rats, Brattleboro
D000185:Actinin