Checkpoint signalling: Mad2 conformers and signal propagation.
The spindle checkpoint protein Mad2 has a tendency to form multimers and adopts at least two structural conformations. New work highlights the importance of the Mad2-Mad2 interaction, and suggests how spindle checkpoint signals are propagated away from kinetochores.
Hardwick
Kevin G
KG
Wellcome Trust Centre for Cell Biology,University of Edinburgh, Edinburgh EH93JR, UK. Kevin.Hardwick@ed.ac.uk
D002135:Calcium-Binding Proteins / Q000378:metabolism*; D064199:Cdc20 Proteins; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D018816:Genes, cdc; D018386:Kinetochores / Q000378:metabolism; D064246:Mad2 Proteins; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D008941:Spindle Apparatus / Q000378:metabolism*
D002135:Calcium-Binding Proteins; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins; C501384:MAD1L1 protein, human; C577697:MAD2L1 protein, human; D064246:Mad2 Proteins; D009687:Nuclear Proteins; D010750:Phosphoproteins; D012097:Repressor Proteins; C577488:CDC20 protein, human