title: Causation in risk assessment and management: models, inference, biases, and a microbial risk-benefit case study.
abstract: Causal inference of exposure-response relations from data is a challenging aspect of risk assessment with important implications for public and private risk management. Such inference, which is fundamentally empirical and based on exposure (or dose)-response models, seldom arises from a single set of data; rather, it requires integrating heterogeneous information from diverse sources and disciplines including epidemiology, toxicology, and cell and molecular biology. The causal aspects we discuss focus on these three aspects: drawing sound inferences about causal relations from one or more observational studies; addressing and resolving biases that can affect a single multivariate empirical exposure-response study; and applying the results from these considerations to the microbiological risk management of human health risks and benefits of a ban on antibiotic use in animals, in the context of banning enrofloxacin or macrolides, antibiotics used against bacterial illnesses in poultry, and the effects of such bans on changing the risk of human food-borne campylobacteriosis infections. The purposes of this paper are to describe novel causal methods for assessing empirical causation and inference; exemplify how to deal with biases that routinely arise in multivariate exposure- or dose-response modeling; and provide a simplified discussion of a case study of causal inference using microbial risk analysis as an example. The case study supports the conclusion that the human health benefits from a ban are unlikely to be greater than the excess human health risks that it could create, even when accounting for uncertainty. We conclude that quantitative causal analysis of risks is a preferable to qualitative assessments because it does not involve unjustified loss of information and is sound under the inferential use of risk results by management.
authors.affiliation: Cox and Associates, Denver and University of Colorado, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Cox
authors.forename: P F
authors.initials: PF
authors.lastname: Ricci
mesh_terms: D000822:Animal Husbandry; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000472:pathogenicity; D001427:Bacterial Toxins; D003362:Cost-Benefit Analysis; D005506:Food Contamination; D006801:Humans; D008962:Models, Theoretical; D015999:Multivariate Analysis; D017149:Private Sector; D011634:Public Health; D017150:Public Sector; D018570:Risk Assessment
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins