Pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis.
An alkene-bridged mimic of the complex DE-bisthioether-ring system of the antibiotic nisin was prepared in one step from the linear precursor.
Ghalit
Nourdin
N
Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB, Utrecht, The Netherlands.
Rijkers
Dirk T S
DT
Kemmink
Johan
J
Versluis
Cees
C
Liskamp
Rob M J
RM
D000475:Alkenes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry; D003500:Cyclization; D008956:Models, Chemical; D009561:Nisin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry; D011487:Protein Conformation
D000475:Alkenes; D000900:Anti-Bacterial Agents; D009561:Nisin; C071364:nisin Z