title: Efficacy and toxicity of zinc salts as candidate topical microbicides against vaginal herpes simplex virus type 2 infection.
abstract: Zinc salt solutions administered as topical microbicides provided significant protection against herpes simplex virus type 2 infection in a mouse vaginal challenge model. However, at the therapeutic concentration, the salt solutions caused sloughing of sheets of vaginal epithelial cells. These observations limit the utility of zinc salts as microbicides and suggest that the application of zinc solutions to mucosal surfaces has the potential to cause damage that might increase susceptibility to secondary infections at a later time.
authors.affiliation: Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd., Galveston, Texas, 77555-0436, USA. nibourne@utmb.edu
authors.forename: Nigel
authors.initials: N
authors.lastname: Bourne
authors.forename: Rachael
authors.initials: R
authors.lastname: Stegall
authors.forename: Raquel
authors.initials: R
authors.lastname: Montano
authors.forename: Michael
authors.initials: M
authors.lastname: Meador
authors.forename: Lawrence R
authors.initials: LR
authors.lastname: Stanberry
authors.forename: Gregg N
authors.initials: GN
authors.lastname: Milligan
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy*; D051379:Mice; D019345:Zinc Acetate / Q000627:therapeutic use; D017967:Zinc Compounds / Q000627:therapeutic use*; D019287:Zinc Sulfate / Q000627:therapeutic use
chemical_list: D000891:Anti-Infective Agents, Local; D017967:Zinc Compounds; D019287:Zinc Sulfate; D019345:Zinc Acetate
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