title: Use of intragastric pH monitoring in gastroesophageal reflux disease.
abstract: Prolonged intragastric pH monitoring is a valuable technique for evaluating head-to-head comparisons of the antisecretory effects of different pharmacologic agents, for studying the effects of higher doses of proton pump inhibitors (PPIs) on daytime and nighttime pH control, for evaluating the effects of dose timing in relation to a meal on the intragastric pH response to these antisecretory agents, and for examining interindividual variability in individual pH response to PPIs taken orally. Measuring intragastric pH has helped immeasurably in understanding the efficacy of PPIs and is especially useful in the clinical arena to guide the management of patients across the spectrum of gastroesophageal reflux disease.
authors.affiliation: Division of Gastroenterology, Albert Einstein Medical Center, 5501 Old York Road, Klein Building, Suite 331, Philadelphia, PA 19141, USA. katzp@einstein.edu
authors.forename: Philip O
authors.initials: PO
authors.lastname: Katz
mesh_terms: D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*; D011379:Prognosis; D054328:Proton Pump Inhibitors; D016032:Randomized Controlled Trials as Topic; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors