title: Nasal polyposis and its impact on quality of life: comparison between the effects of medical and surgical treatments.
abstract: BACKGROUND
  Nasal polyposis (NP) is not a life-threatening disorder but may have a great impact on the quality of life (QoL). The objective of this study: (i) to investigate the health burden incurred by NP compared with the Spanish general population using the Short Form-36 Health Survey (SF-36) questionnaire; (ii) to compare the QoL outcome after medical or surgical treatment; and (iii) to assess and compare the effect of medical and surgical treatment on nasal symptoms.
  
  
  METHODS
  About 109 patients with nasal polyps were included. Fifty-three patients were randomly allocated to receive oral prednisone for 2 weeks and 56 to undergo endoscopic sinus surgery. All patients administered intranasal budesonide for 12 months. Patients were evaluated for nasal symptoms, polyp size, and QoL.
  
  
  RESULTS
  In comparison with the Spanish general population, patients with NP had worse scores on all SF-36 domains except for physical functioning. Nonasthmatic patients with NP had better QoL than asthmatic patients with NP on role physical functioning, body pain, and vitality (P <0.05). At 6 and 12 months, a significant improvement on all of SF-36 domains was observed after both medical and surgical treatment reaching the levels of general population (P <0.05). Nasal symptoms and polyp size improved after both medical and surgical treatment at 6 and 12 months (P <0.05).
  
  
  CONCLUSIONS
  These results suggest that NP has considerable impact on a patient's QoL and that both medical and surgical treatment led to similar effects in improving QoL.
authors.affiliation: Department of Otorhinolaryngology, Rhinology Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Alobid
authors.forename: P
authors.initials: P
authors.lastname: Benítez
authors.forename: M
authors.initials: M
authors.lastname: Bernal-Sprekelsen
authors.forename: J
authors.initials: J
authors.lastname: Roca
authors.forename: J
authors.initials: J
authors.lastname: Alonso
authors.forename: C
authors.initials: C
authors.lastname: Picado
authors.forename: J
authors.initials: J
authors.lastname: Mullol
mesh_terms: D001249:Asthma / Q000150:complications; D004724:Endoscopy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D011241:Prednisone / Q000627:therapeutic use*; D011788:Quality of Life; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D011241:Prednisone