Molecular biology of ureteral bud and trigonal development.
Advances in molecular biology have provided valuable insight into the development of the urinary tract, particularly ureteral bud formation. Reciprocal inductive signals between the ureteral bud and growing kidney are crucial for normal development. The Wolffian duct serves as the site of origin of the ureteral bud and forms distal excretory ducts that are incorporated into the developing bladder to become the trigone. Vesicoureteral reflux and renal dysplasia can result from abnormal position of the ureteral orifice on the trigone. The presumed origin of trigone formation is based largely on evaluation of human and animal models performed nearly a century ago. The trigone is thought to develop from the mesodermal germ cell layer; however, several recent studies have shown that endoderm may be the tissue of origin. This review highlights important discoveries in the field of molecular biology as it relates to the development of normal and abnormal ureteral bud formation. It also describes the anatomic relationship between the developing bud and trigone as it pertains to clinically relevant urinary tract anomalies, including recent discoveries that attempt to prove the origin of the trigone.
Thomas
John C
JC
Department of Urologic Surgery, Division of Pediatric Urology, Vanderbilt Children's Hospital, 435 Medical Arts Building, 1211 21st Avenue South, Nashville, TN 37212-2721, USA.
DeMarco
Romano T
RT
Pope
John C
JC
D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000196:embryology*; D008297:Male; D008967:Molecular Biology; D038081:Organogenesis / Q000502:physiology*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D014513:Ureter / Q000196:embryology*; D014566:Urogenital System / Q000196:embryology; D014718:Vesico-Ureteral Reflux / Q000209:etiology / Q000503:physiopathology
Kidney Int. 2002 Jan;61(1):10-9
11786080
Development. 1997 Oct;124(20):4077-87
9374404
Dev Biol. 2004 Feb 15;266(2):285-98
14738877
Mol Cell. 1999 Jan;3(1):1-10
10024874
Development. 2001 Dec;128(23):4747-56
11731455
J Urol. 2002 Sep;168(3):1165-72
12187262
Curr Opin Genet Dev. 2000 Oct;10(5):543-9
10980433
J Urol. 2002 Jun;167(6):2339-50; discussion 2350-1
11992035
Semin Cell Dev Biol. 2003 Aug;14(4):217-24
14627120
Development. 1997 May;124(9):1653-64
9165114
J Am Soc Nephrol. 1999 Sep;10(9):2018-28
10477156
Development. 1995 Dec;121(12):4057-65
8575306
J Urol. 1998 Sep;160(3 Pt 2):1070-4
9719278
J Urol. 2001 Jan;165(1):196-202
11125405
Cancer Surv. 1991;11:73-90
1841758
Development. 2003 Jul;130(14):3175-85
12783789
Mech Dev. 1997 Mar;62(2):105-20
9152004
Urology. 1978 Feb;11(2):161-3
628993
Science. 1953 Jul 10;118(3054):52-5
13076182
J Clin Invest. 2000 Apr;105(7):863-73
10749566
J Urol. 1965 Feb;93:165-76
14260208
J Urol. 1975 Aug;114(2):274-80
1171997
Development. 1996 Jun;122(6):1919-29
8674430
J Urol. 1996 Nov;156(5):1820-7
8863624
J Urol. 1968 Nov;100(5):623-32
5682537
J Urol. 2001 Nov;166(5):1848-52
11586245
Kidney Int. 1995 Jan;47(1):140-7
7731139