title: Fine-scale recombination patterns differ between chimpanzees and humans.
abstract: Recombination rates seem to vary extensively along the human genome. Pedigree analysis suggests that rates vary by an order of magnitude when measured at the megabase scale, and at a finer scale, sperm typing studies point to the existence of recombination hotspots. These are short regions (1-2 kb) in which recombination rates are 10-1,000 times higher than the background rate. Less is known about how recombination rates change over time. Here we determined to what degree recombination rates are conserved among closely related species by estimating recombination rates from 14 Mb of linkage disequilibrium data in central chimpanzee and human populations. The results suggest that recombination hotspots are not conserved between the two species and that recombination rates in larger (50 kb) genomic regions are only weakly conserved. Therefore, the recombination landscape has changed markedly between the two species.
authors.affiliation: Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6 04103, Leipzig, Germany. ptak@email.eva.mpg.de
authors.forename: Susan E
authors.initials: SE
authors.lastname: Ptak
authors.forename: David A
authors.initials: DA
authors.lastname: Hinds
authors.forename: Kathrin
authors.initials: K
authors.lastname: Koehler
authors.forename: Birgit
authors.initials: B
authors.lastname: Nickel
authors.forename: Nila
authors.initials: N
authors.lastname: Patil
authors.forename: Dennis G
authors.initials: DG
authors.lastname: Ballinger
authors.forename: Molly
authors.initials: M
authors.lastname: Przeworski
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Frazer
authors.forename: Svante
authors.initials: S
authors.lastname: Pääbo
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003198:Computer Simulation; D014644:Genetic Variation; D005828:Genetics, Population; D016678:Genome; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D002679:Pan troglodytes / Q000235:genetics*; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic