Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms.
Children undergoing surgery with infant-onset epilepsy were classified into those with medically refractory infantile spasms (IS), successfully treated IS, and no IS history, and the groups were compared for pre- and postsurgery clinical and Vineland Adaptive Behavior Scale (VABS) developmental quotients (DQ). Children without an IS history were older at surgery and had longer epilepsy durations than those with IS despite similar substrates, surgeries, and seizure frequencies. In all groups, better postsurgery VABS-DQ scores were associated with early surgical intervention indicating that infant-onset epilepsy patients with or without IS are at risk for seizure-induced encephalopathy.
Jonas
R
R
Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, USA.
Asarnow
R F
RF
LoPresti
C
C
Yudovin
S
S
Koh
S
S
Wu
J Y
JY
Sankar
R
R
Shields
W D
WD
Vinters
H V
HV
Mathern
G W
GW
D015331:Cohort Studies; D002658:Developmental Disabilities / Q000209:etiology; D004351:Drug Resistance; D042241:Early Diagnosis; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007431:Intraoperative Complications / Q000401:mortality; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology; D011184:Postoperative Period; D011300:Preoperative Care; D011581:Psychological Tests; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013036:Spasms, Infantile / Q000188:drug therapy / Q000601:surgery*; D013686:Telemetry; D016896:Treatment Outcome; D014741:Video Recording