title: Morphometry demonstrates loss of cortical thickness in cerebral microangiopathy.
abstract: OBJECTIVE
  To evaluate the role of MR morphometry in the characterization of cerebral microangiopathy (CMA) in relation to clinical and neuropsychological impairment.
  
  
  METHODS
  3D MR images of 27 patients and 27 age-matched controls were morphometrically analysed for regional thickness. The normalized values were related to the patients' clinical and neuropsychological scores. The patients were categorised according to the amount of structural MR signal changes. A ventricle index reflecting internal atrophy was related to MR morphology and cortical thickness as an indicator for external atrophy.
  
  
  RESULTS
  Cortical thickness was significantly reduced in the patients group (3.03 mm +/- 0.26 vs. 3.22 mm +/-0.13 in controls, p=0.001). The severest loss of cortical thickness occurred in severe CMA. Internal and external atrophy evolved in parallel and both showed a significant relationship with structural MR-abnormalities (p<0.05; r=-0.7; r=0.67; r=-0.74, respectively). Neuropsychological performance correlated strongly with the loss of cortical thickness.
  
  
  CONCLUSIONS
  Cortical thickness was identified as the most sensitive parameter to characterize CMA. A strong correlation was found of morphometric parameters to the severity of CMA based on a score derived from T2-weighted MRI. The degree of cortical atrophy was directly related to the degree of neuropsychological impairment. Our findings suggest that the cortical thickness is a valid marker in the structural and clinical characterization of CMA.
authors.affiliation: Max-Planck-Institute of Human Cognitive and Brain Sciences, Stephanstrasse 1a, 04103 Leipzig, Germany. preul@cbs.mpg.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Preul
authors.forename: Gabriele
authors.initials: G
authors.lastname: Lohmann
authors.forename: Margret
authors.initials: M
authors.lastname: Hund-Georgiadis
authors.forename: Thomas
authors.initials: T
authors.lastname: Guthke
authors.forename: D Yves
authors.initials: DY
authors.lastname: von Cramon
mesh_terms: D000704:Analysis of Variance; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000473:pathology* / Q000503:physiopathology; D003072:Cognition Disorders; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D013223:Statistics as Topic; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed; D018615:Ultrasonography, Doppler, Color / Q000379:methods
chemical_list: D019690:Technetium Tc 99m Exametazime
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