Epigenetic control of B cell differentiation.
Gene expression, differentiation and the specialized function of various cell types are controlled epigenetically by post-translational histone modifications. These modifications establish a "histone code" that is recognized by various regulatory proteins, thereby creating a stable pattern of gene expression. The focus of this review is to discuss how the chromatin modifications regulate immunoglobulin gene rearrangement and B cell differentiation.
Su
I-hsin
IH
Laboratory of Lymphocyte Signalling, The Rockefeller University, 1230 York Avenue, Box 301, New York, NY 10021, USA. sui@mail.rockefeller.edu
Tarakhovsky
Alexander
A
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation / Q000235:genetics; D002843:Chromatin / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D038041:Lymphopoiesis / Q000235:genetics*; D063146:Polycomb-Group Proteins; D011499:Protein Processing, Post-Translational; D011995:Recombination, Genetic; D012097:Repressor Proteins
D002843:Chromatin; D007136:Immunoglobulins; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins