title: Opioids and central sensitisation: II. Induction and reversal of hyperalgesia.
abstract: Opioids are powerful analgesics when used to treat acute pain and some forms of chronic pain. In addition, opioids can preempt some forms of central sensitization. Here we review evidence that opioids may also induce and perhaps reverse some forms of central sensitization.
authors.affiliation: Department of Neurophysiology, Centre for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria.
authors.forename: Ruth
authors.initials: R
authors.lastname: Ruscheweyh
authors.forename: Jürgen
authors.initials: J
authors.lastname: Sandkühler
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects*; D000818:Animals; D004359:Drug Therapy, Combination; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage*; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced* / Q000517:prevention & control*
chemical_list: D000701:Analgesics, Opioid; D018691:Excitatory Amino Acid Antagonists