Secondary generalized dystonia without basal ganglia damage.
We report the case of a woman who developed generalized dystonia, severe cognitive deficits and dysphagia following an overdose of the hypoglycaemic drug, sulphonylurea. The MRI reveals frontal and temporal lobe atrophy, but no evidence of damage to the basal ganglia. This case adds to the small number of previously reported cases with secondary dystonia seemingly due to cortical rather than subcortical damage.
Mahapatra
Robert K
RK
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Mir
Pablo
P
Edwards
Mark J
MJ
Allen
David
D
Bhatia
Kailash P
KP
D000328:Adult; D001479:Basal Ganglia; D003680:Deglutition Disorders / Q000139:chemically induced / Q000473:pathology; D004421:Dystonia / Q000139:chemically induced* / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007004:Hypoglycemic Agents / Q000506:poisoning*; D008279:Magnetic Resonance Imaging; D013406:Suicide, Attempted; D013453:Sulfonylurea Compounds / Q000506:poisoning*; D013702:Temporal Lobe / Q000473:pathology
D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds