A comparison of electronic monitoring vs. clinician rating of antipsychotic adherence in outpatients with schizophrenia.
Antipsychotic non-adherence rates of outpatients with schizophrenia or schizoaffective disorder was assessed by electronic monitoring and clinician rating. Antipsychotic adherence was determined monthly over 3 consecutive months with (1) the Medication Event Monitoring System (MEMS) cap and (2) the Clinician Rating Scale. Non-adherence was defined as daily adherence of <70% during any one of three monthly evaluations for MEMS and ratings of <or=4 (scale of 1-7) on the Clinician Rating Scale. Non-adherence was detected in 12 of 25 patients (48%) by MEMS and 0% by the Clinician Rating Scale. Clinician assessment dramatically underestimated antipsychotic non-adherence.
Byerly
Matthew
M
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. Matt.Byerly@UTSouthwestern.edu
Fisher
Robert
R
Whatley
Katrina
K
Holland
Rhiannon
R
Varghese
Femina
F
Carmody
Thomas
T
Magouirk
Brianne
B
Rush
A John
AJ
D000328:Adult; D000553:Ambulatory Care; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D016903:Drug Monitoring / Q000295:instrumentation*; D004581:Electronics / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008509:Medication Systems; D015588:Observer Variation; D010349:Patient Compliance / Q000706:statistics & numerical data*; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents