Micropet imaging: in vivo biochemistry in small animals.
Significant technological advancements required for imaging physiological function in small animals have been achieved in the last few years. Dedicated small animals PET scanners are now achieving resolutions that approach the one obtainable by autoradiographic methods, while still maintaining enough detection sensitivity to reliably measure biologically relevant parameters such as binding potentials or rate constants. Such developments have enabled researchers to explore in-vivo rodent models of human disease. The future in imaging now lies in the development of multi-modality imaging approaches, while the big challenge in the next few years will be for the chemists to develop tracers that are more specific and reflective of the functional condition under investigation, while miniaturizing the chemical synthesis related instrumentation.
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University of British Columbia/TRIUMF PET Program, Vancouver, B.C., Canada. vesna@physics.ubc.ca
Ruth
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TJ
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods* / Q000639:trends / Q000662:veterinary; D051381:Rats; D013045:Species Specificity