[Effect of zhitiaokang capsule on serum insulin-like growth factor-2 in patients with hyperlipidemia].
OBJECTIVE
To observe the effect of Zhitiaokang capsule (ZTK) on serum insulin-like growth factor-2 (IGF-2) in patients with hyperlipidemia (HLP).


METHODS
Patients with HLP were randomly divided into the treated group (n = 124) and the control group (n = 62), they were treated by ZTK and Zhibituo tablet respectively for 8 weeks as one therapeutic course. The changes of blood lipids and serum IGF-2 before and after treatment were observed.


RESULTS
ZTK could significantly reduce blood lipids and increase serum content of IGF-2.


CONCLUSIONS
ZTK could improve the insulin resistant status and inhibit the development of hyperlipidemia in patients by means of raising serum content of IGF-2 and suppressing vascular endothelial cell apoptosis.
Yang
Mu-xiang
MX
College of TCM, Hebei Medical University, Shijiazhuang. yangmx427@163.com
Su
Feng-zhe
FZ
Yu
Wen-tao
WT
Tian
Yuanxiang
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007335:Insulin-Like Growth Factor II; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011506:Proteins / Q000378:metabolism*
D002214:Capsules; D004365:Drugs, Chinese Herbal; D000960:Hypolipidemic Agents; C035170:IGF2 protein, human; D011506:Proteins; D007335:Insulin-Like Growth Factor II