title: Prostatic neuroendocrine tumor in multiple endocrine neoplasia Type 2B.
abstract: We report the unusual occurrence of a neuroendocrine prostatic tumor in two young males with multiple endocrine neoplasia (MEN) 2B. Immunohistochemistry of the tumor markers may help differentiate a primary neuroendocrine prostate tumor from the metastasis of a medullary thyroid carcinoma of poor prognosis. MEN 2B hallmarks (i.e. plasma thyrocalcitonin and urinary metanephrines) may be systematically investigated in neuroendocrine tumors of the prostate, and conversely prostate examination may be performed in the periodic screening of MEN 2B male patients.
authors.affiliation: Department of Endocrinology Hospital CHU, Caen, France. bsalmon@ch-aleucom.fr
authors.forename: B
authors.initials: B
authors.lastname: Goulet-Salmon
authors.forename: E
authors.initials: E
authors.lastname: Berthe
authors.forename: S
authors.initials: S
authors.lastname: Franc
authors.forename: S
authors.initials: S
authors.lastname: Chanel
authors.forename: F
authors.initials: F
authors.lastname: Galateau-Salle
authors.forename: M
authors.initials: M
authors.lastname: Kottler
authors.forename: J
authors.initials: J
authors.lastname: Mahoudeau
authors.forename: Y
authors.initials: Y
authors.lastname: Reznik
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018814:Multiple Endocrine Neoplasia Type 2b / Q000175:diagnosis / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000473:pathology*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
references.citation: Arch Pathol Lab Med. 1989 Jul;113(7):790-6
references.pmid: 2787149
references.citation: Development. 1991 Dec;113(4):1093-104
references.pmid: 1811929
references.citation: Prostate. 1989;14(1):71-81
references.pmid: 2467274
references.citation: Scand J Urol Nephrol. 1996 Dec;30(6):503-8
references.pmid: 9008036
references.citation: Arch Pathol Lab Med. 2001 Feb;125(2):228-31
references.pmid: 11175640
references.citation: Mod Pathol. 2000 Mar;13(3):238-42
references.pmid: 10757334
references.citation: Arch Pathol Lab Med. 1984 Sep;108(9):693-6
references.pmid: 6147124
references.citation: Pathol Res Pract. 1986 Dec;181(6):675-83
references.pmid: 2436200
references.citation: Cancer. 1984 Jun 1;53(11):2478-80
references.pmid: 6324985
references.citation: J Urol. 1995 Mar;153(3 Pt 2):1080-2
references.pmid: 7853568
references.citation: J Urol (Paris). 1996;102(4):188-90
references.pmid: 9091572
references.citation: Hum Pathol. 1992 Mar;23(3):287-96
references.pmid: 1313390
references.citation: Cancer. 1987 Mar 1;59(5):977-82
references.pmid: 2434204
references.citation: Cancer. 1992 Jul 1;70(1 Suppl):254-68
references.pmid: 1350941
references.citation: Scand J Urol Nephrol. 1997 Oct;31(5):501-3
references.pmid: 9406316
references.citation: Biochimie. 1999 Apr;81(4):389-96
references.pmid: 10401674
references.citation: Am J Surg Pathol. 2000 Sep;24(9):1217-23
references.pmid: 10976695
references.citation: Q J Nucl Med. 1997 Mar;41(1):36-41
references.pmid: 9195851
references.citation: Arch Pathol Lab Med. 1985 Jul;109(7):607-12
references.pmid: 2409946
references.citation: Endocr Relat Cancer. 1999 Dec;6(4):503-19
references.pmid: 10730904
references.citation: Appl Immunohistochem Mol Morphol. 2000 Sep;8(3):189-94
references.pmid: 10981870
references.citation: Hum Pathol. 2000 Mar;31(3):386-93
references.pmid: 10746684
references.citation: Arch Pathol Lab Med. 1986 May;110(5):412-5
references.pmid: 3754425
references.citation: Ann Clin Lab Sci. 1996 Nov-Dec;26(6):487-95
references.pmid: 8908318
references.citation: Hybridoma. 1996 Feb;15(1):49-53
references.pmid: 9064286
references.citation: Clin Oncol (R Coll Radiol). 1997;9(6):412-4
references.pmid: 9448972
references.citation: Kidney Int. 1991 Sep;40(3):544-56
references.pmid: 1787652
references.citation: Virchows Arch A Pathol Anat Histopathol. 1986;409(4):523-33
references.pmid: 2874650
references.citation: Am J Surg. 1987 Jul;154(1):142-8
references.pmid: 2886072
references.citation: Mod Pathol. 1996 Apr;9(4):445-52
references.pmid: 8729987