title: Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding.
abstract: Pt(C/N)(phe)(1, C/N = 2-(2'-thienyl)pyridine, phe = phenylalanine) shows a high binding affinity (ca. 10(6) dm(3) mol(-1)) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of [Pt(C/N)(phe)(1), Pt(C/N)(trp)(2, trp = tryptophan) and Pt(C/N)(gly)(3, gly = glycine)] are affected by the amino acid ligand with having an IC(50) of up to 1 microM against a number of carcinoma cell lines.
authors.affiliation: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.
authors.forename: Phyllis Kit-Man
authors.initials: PK
authors.lastname: Siu
authors.forename: Dik-Lung
authors.initials: DL
authors.lastname: Ma
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism*; D045744:Cell Line, Tumor; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D049408:Luminescent Agents / Q000737:chemistry* / Q000378:metabolism; D008163:Luminescent Measurements; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010984:Platinum / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D008024:Ligands; D049408:Luminescent Agents; D009942:Organometallic Compounds; D012709:Serum Albumin; D010984:Platinum