title: Cisplatin nanocapsules.
abstract: Cisplatin nanocapsules represent a novel lipid formulation of the anticancer drug cis-diamminedichloroplatinum(II), in which nanoprecipitates of cisplatin are covered by a phospholipid bilayer coat consisting of an equimolar mixture of phosphatidylcholine and phosphatidylserine. Cisplatin nanocapsules are characterized by an unprecedented cisplatin-to-lipid molar ratio and exhibit strongly improved cytotoxicity against tumor cells in vitro compared with the free drug. Here, methods for preparing and characterizing cisplatin nanocapsules are reported.
authors.affiliation: Department of Biochemistry and Membranes, Utrecht University, Utrecht, The Netherlands.
authors.forename: Anton I P M
authors.initials: AI
authors.lastname: de Kroon
authors.forename: Rutger W H M
authors.initials: RW
authors.lastname: Staffhorst
authors.forename: Ben de
authors.initials: Bd
authors.lastname: Kruijff
authors.forename: Koert N J
authors.initials: KN
authors.lastname: Burger
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D002945:Cisplatin / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D006801:Humans; D015394:Molecular Structure; D049329:Nanostructures; D010743:Phospholipids / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010743:Phospholipids; D002945:Cisplatin