title: Epidemiology of dengue and dengue hemorrhagic fever in a cohort of adults living in Bandung, West Java, Indonesia.
abstract: A prospective study of dengue fever (DF) and dengue hemorrhagic fever (DHF) was conducted in a cohort of adult volunteers from two textile factories located in West Java, Indonesia. Volunteers in the cohort were bled every three months and were actively followed for the occurrence of dengue (DEN) disease. The first two years of the study showed an incidence of symptomatic DEN disease of 18 cases per 1,000 person-years and an estimated asymptomatic/ mild infection rate of 56 cases per 1,000 person-years in areas of high disease transmission. In areas where no symptomatic cases were detected, the incidence of asymptomatic or mild infection was 8 cases per 1,000 person-years. Dengue-2 virus was the predominant serotype identified, but all four serotypes were detected among the cohort. Four cases of DHF and one case of dengue shock syndrome (DSS) were identified. Three of the four DHF cases were due to DEN-3 virus. The one DSS case occurred in the setting of a prior DEN-2 virus infection, followed by a secondary infection with DEN-1 virus. To our knowledge, this is the first report of a longitudinal cohort study of naturally acquired DF and DHF in adults.
authors.affiliation: Viral Diseases Program, Naval Medical Research Unit No. 2, Jakarta, Indonesia. porterk@nmrc.navy.mil
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Porter
authors.forename: Charmagne G
authors.initials: CG
authors.lastname: Beckett
authors.forename: Herman
authors.initials: H
authors.lastname: Kosasih
authors.forename: Ratna Irsiana
authors.initials: RI
authors.lastname: Tan
authors.forename: Bachti
authors.initials: B
authors.lastname: Alisjahbana
authors.forename: Pandji Irani Fianza
authors.initials: PI
authors.lastname: Rudiman
authors.forename: Susana
authors.initials: S
authors.lastname: Widjaja
authors.forename: Erlin
authors.initials: E
authors.lastname: Listiyaningsih
authors.forename: Chairin Nisa
authors.initials: CN
authors.lastname: Ma'Roef
authors.forename: James L
authors.initials: JL
authors.lastname: McArdle
authors.forename: Ida
authors.initials: I
authors.lastname: Parwati
authors.forename: Primal
authors.initials: P
authors.lastname: Sudjana
authors.forename: Hadi
authors.initials: H
authors.lastname: Jusuf
authors.forename: Djoko
authors.initials: D
authors.lastname: Yuwono
authors.forename: Suharyono
authors.initials: S
authors.lastname: Wuryadi
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D015331:Cohort Studies; D003716:Dengue Virus / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D019595:Severe Dengue / Q000453:epidemiology* / Q000276:immunology / Q000821:virology
chemical_list: D000914:Antibodies, Viral