Antihistamine effects of triprolidine from the transdermal administration of the TPX matrix in rats.
The antihistamine effects of the triprolidine were studied in rats to determine the feasibility of their enhanced transdermal delivery from the poly (4-methyl-1-pentene) (TPX) matrix system containing penetration enhancer and plasticizer. The antihistamine effects were determined by the Evans blue dye procedure by comparing the changes in vascular permeability increase following the transdermal administration. The vascular permeability increase was significantly reduced by transdermal administration of the triprolidine-TPX system containing triethyl citrate (TEC) and polyoxyethylene-2-oleyl ether (POE). Both the plasticizer and penetration enhancer played an important role in the skin permeation of triprolidine and increased the antihistamine effects. These results showed that the triprolidine-TPX matrix system containing plasticizer and penetration enhancer could be a transdermal delivery system providing the increased antihistamine effects.
Shin
Sang-Chul
SC
College of Pharmacy, Chonnam National University, Gwangju 500-757, Korea.
Choi
Jun-Shik
JS
D000279:Administration, Cutaneous; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects / Q000502:physiology; D002951:Citrates / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D051381:Rats; D014311:Triprolidine / Q000008:administration & dosage*
D002951:Citrates; D006634:Histamine H1 Antagonists; D014311:Triprolidine; D011092:Polyethylene Glycols; C023001:ethyl citrate