IRS-1 and vascular complications in diabetes mellitus.
The expected explosive increase in the number of patients with diabetes mellitus will increase the stress on health care. Treatment is focused on preventing vascular complications associated with the disorder. In order to develop better treatment regimens, the field of research has made a great effort in understanding this disorder. This chapter summarizes the current views on the insulin signaling pathway with emphasis on intracellular signaling events associated with insulin resistance, which lead to the prothrombotic condition in the vasculature of patience with diabetes mellitus.
Andrade Ferreira
I
I
Thrombosis and Haemostasis Laboratory, Department of Hematology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Akkerman
J W N
JW
D000595:Amino Acid Sequence; D000818:Animals; D003925:Diabetic Angiopathies; D006801:Humans; D055504:Insulin Receptor Substrate Proteins; D007333:Insulin Resistance; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000737:chemistry / Q000502:physiology; D011972:Receptor, Insulin; D015398:Signal Transduction
C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins; D010750:Phosphoproteins; D011972:Receptor, Insulin