Evaluation of ovarian functionality after a dietary treatment in obese women with polycystic ovary syndrome.
In women with polycystic ovary syndrome (PCOS) weight loss is associated with an improvement in insulin sensitivity and a reduction of the insulin concentration in the plasma. It is clear, then, that the first therapeutic approach that can be considered in obese PCOS patients for restoration of the menstrual cycle should be a diet. The aim of our study was to examine the effect of long-term caloric restriction on the clinical and biochemical abnormalities in obese PCOS women. The results obtained make it clear that caloric restriction for 4 weeks causes an increase in SHBG and decreases of free testosterone and insulin, with consequent improvement of the clinical picture.
Tolino
A
A
Dipartimento di Scienze Ostetrico-Ginecologiche, Urologiche e Medicina della Riproduzione, Università Degli Studi di Napoli Federico II, Napoli, Italy.
Gambardella
V
V
Caccavale
C
C
D'Ettore
A
A
Giannotti
F
F
D'Antò
V
V
De Falco
C L
CL
D031204:Caloric Restriction; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D009765:Obesity / Q000150:complications / Q000178:diet therapy* / Q000503:physiopathology*; D010053:Ovary / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000503:physiopathology*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood
D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone