Epstein-Barr virus-associated lymphoproliferative disorder presenting as apparently isolated gastrointestinal lesions in childhood.
We present an unusual case of post-transplant lymphoproliferative disorder (PTLD) presenting as apparently isolated gastrointestinal lesions in a pediatric renal transplant recipient. The multiple bowel lesions were related to Epstein-Barr virus and demonstrated the appearance of a monomorphic PTLD that was morphologically indistinguishable from diffuse large B-cell lymphoma. The patient responded to therapy with targeted anti-CD20 immunotherapy. PTLD may manifest as apparently isolated gastrointestinal tract lesions in childhood.
Sebire
N J
NJ
Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, United Kingdom. sebirn@gosh.nhs.uk
Malone
M
M
Risdon
R A
RA
Ramsay
A D
AD
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D007082:Ileum / Q000473:pathology / Q000601:surgery; D007167:Immunotherapy; D007410:Intestinal Diseases / Q000175:diagnosis* / Q000628:therapy / Q000821:virology; D016030:Kidney Transplantation / Q000009:adverse effects; D016393:Lymphoma, B-Cell / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000628:therapy / Q000821:virology; D008297:Male; D011183:Postoperative Complications; D000069283:Rituximab; D016896:Treatment Outcome; D014456:Ulcer / Q000473:pathology / Q000601:surgery
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab