title: The Intelligent Dosing System: application for insulin therapy and diabetes management.
abstract: Diabetes mellitus is an increasing public health problem. Insulin is an essential tool in the management of hyperglycemia, but methods of dose adjustment are purely empirical. The Intelligent Dosing System (IDS, Dimensional Dosing Systems, Inc., Wexford, PA) is a software suite that incorporates patient-specific, dose-response data in a mathematical model and then calculates the new dose of the medication needed to achieve the next desired therapeutic goal. We discuss the application of the IDS in insulin management. The IDS concept and the initial modeling used to construct an insulin doser are reviewed first. Additional data are then provided on the use of the IDS for titrating insulin therapy in a clinical setting. Finally, recent modifications in the IDS software and future applications of this technology for insulin dosing and diabetes management are discussed.
authors.affiliation: Division of Endocrinology, Mayo Clinic, Scottsdale, Arizona 85259, USA. Cook.Curtiss@mayo.edu
authors.forename: Curtiss B
authors.initials: CB
authors.lastname: Cook
authors.forename: John P
authors.initials: JP
authors.lastname: McMichael
authors.forename: Ron
authors.initials: R
authors.lastname: Lieberman
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Mann
authors.forename: Esther C
authors.initials: EC
authors.lastname: King
authors.forename: Katina M
authors.initials: KM
authors.lastname: New
authors.forename: Pamela S
authors.initials: PS
authors.lastname: Vaughn
authors.forename: Virginia G
authors.initials: VG
authors.lastname: Dunbar
authors.forename: Jane M
authors.initials: JM
authors.lastname: Caudle
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use*; D007332:Insulin Infusion Systems; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D007328:Insulin