Activity of cathelicidin peptides against Chlamydia spp.
The in vitro activity of six cathelicidin peptides against 25 strains of Chlamydia was investigated. SMAP-29 proved to be the most active peptide, reducing the inclusion numbers of all 10 strains of Chlamydia trachomatis tested by > or =50% at 10 microg/ml. This peptide was also active against C. pneumoniae and C. felis.
Donati
Manuela
M
Sezione di Microbiologia, DMCSS, Policlinico S.Orsola, Università di Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Di Leo
Korinne
K
Benincasa
Monica
M
Cavrini
Francesca
F
Accardo
Silvia
S
Moroni
Alessandra
A
Gennaro
Renato
R
Cevenini
Roberto
R
D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D001798:Blood Proteins / Q000494:pharmacology*; D054804:Cathelicidins; D002689:Chlamydia / Q000187:drug effects*; D002692:Chlamydia trachomatis / Q000187:drug effects; D016993:Chlamydophila pneumoniae / Q000187:drug effects; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*
D023181:Antimicrobial Cationic Peptides; C102359:BMAP-27; C102360:BMAP-28; D001798:Blood Proteins; D054804:Cathelicidins; D010456:Peptides, Cyclic; D011506:Proteins; C403305:SMAP29 protein, Ovis aries; C094880:protegrin-1; C056454:bactenecin
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