title: [Protective effects of total flavones of metasequosia on cerebral ischemia-reperfusion injury in rats].
abstract: OBJECTIVE
  To observe the protective effects of total flavones of metasequosia (TFM) on cerebral ischemia-reperfusion injury in rats.
  
  
  METHODS
  The bilateral vertebral arteries of rats were occluded under anesthesia, and 4-5 h later the carotid arteries of rats in the conscious condition were occluded for 30 min followed by reperfusion for 90 min. The effects of TFM on the contents of water, Na+, Ca2+ in cortex, malondialdehyde (MDA) content and superoxide dismutase (SOD) activity in brain hemispheres, as well as the EEG activities were observed.
  
  
  RESULTS
  After 30 min ischemia and 90 min reperfusion, the contents of water, Na+ , Ca2+ and MDA were increased, and the SOD activity was reduced with abnormal EEG activity and ischemic injury in the brain tissues. TFM 25-100 mg x kg(-1) ip 30 min before the carotid arteries were occluded, decreased the elevated water, Na+, Ca2+ and MDA contents, increased the SOD activity, reduced the ischemic injury of brain tissue, and promoted the recovery of EEG activities.
  
  
  CONCLUSIONS
  TFM has a protective effect on cerebral ischemia-reperfusion injury in rats.
authors.affiliation: Dept of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China. yunianlin@sohu.com
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: En-xin
authors.initials: EX
authors.lastname: Yu
authors.forename: Wei-wan
authors.initials: WW
authors.lastname: Liu
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002545:Brain Ischemia / Q000150:complications; D029779:Cupressaceae / Q000737:chemistry; D004569:Electroencephalography / Q000187:drug effects; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology
chemical_list: D047309:Flavones; D018696:Neuroprotective Agents