[One decade of functional imaging in schizophrenia research. From visualisation of basic information processing steps to molecular-genetic oriented imaging].
Modern neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) have contributed tremendously to our current understanding of psychiatric disorders in the context of functional, biochemical and microstructural alterations of the brain. Since the mid-nineties, functional MRI has provided major insights into the neurobiological correlates of signs and symptoms in schizophrenia. The current paper reviews important fMRI studies of the past decade in the domains of motor, visual, auditory, attentional and working memory function. Special emphasis is given to new methodological approaches, such as the visualisation of medication effects and the functional characterisation of risk genes.
Tost
H
H
NMR-Forschung in der Psychiatrie, Zentralinstitut für Seelische Gesundheit, Mannheim. tost@zi-mannheim.de
Meyer-Lindenberg
A
A
Ruf
M
M
Demirakça
T
T
Grimm
O
O
Henn
F A
FA
Ende
G
G
D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D002986:Clinical Trials as Topic; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends; D008967:Molecular Biology / Q000379:methods*; D012107:Research Design; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism
D015415:Biomarkers
Psychiatry Res. 1997 Oct 31;75(3):145-57
9437772
Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):883-90
9448255
Schizophr Res. 1997 Oct 17;27(1):1-10
9373889
Mol Psychiatry. 2005 Jan;10(1):40-68; image 5
15263907
J Neuropsychiatry Clin Neurosci. 1994 Fall;6(4):348-57
7841806
J Psychiatr Res. 1984;18(1):57-72
6371224
Psychiatry Res. 1997 Mar 14;74(1):13-23
10710159
Psychiatry Res. 2003 May 1;123(1):1-15
12738340
Biol Psychiatry. 2002 Jun 15;51(12):1008-11
12062886
Am J Psychiatry. 1990 Nov;147(11):1457-62
2221156
J Psychiatr Res. 1984;18(1):27-55
6371223
Neuropsychiatry Neuropsychol Behav Neurol. 1999 Jul;12(3):170-7
10456801
Neuroreport. 2003 Oct 6;14(14):1833-6
14534430
Mol Psychiatry. 1999 May;4(3):286-9
10395222
Biol Psychiatry. 2000 Jul 15;48(2):99-109
10903406
Psychiatry Res. 2000 May 15;98(3):145-54
10821997
J Abnorm Psychol. 2003 Nov;112(4):689-97
14674880
Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12604-9
15310849
Neuropsychopharmacology. 2004 Nov;29(11):1943-61
15305167
Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6917-22
11381111
Brain Res Brain Res Rev. 2000 Mar;31(2-3):295-301
10719156
Biol Psychiatry. 1990 Feb 15;27(4):377-99
2106922
Am J Psychiatry. 2001 Sep;158(9):1423-8
11532726
Lancet. 1995 Oct 14;346(8981):1035
7475566
Neurosci Lett. 2000 Oct 20;293(1):69-71
11065140
Am J Psychiatry. 2004 Apr;161(4):707-15
15056518
Neuron. 1999 Apr;22(4):751-61
10230795
Nature. 1995 Nov 9;378(6553):176-9
7477318
Neuroreport. 1996 Mar 22;7(4):932-6
8724677
Science. 2003 Feb 21;299(5610):1240-3
12595695
Am J Psychiatry. 1996 May;153(5):687-92
8615416
Cereb Cortex. 1999 Jan-Feb;9(1):20-6
10022492
Am J Psychiatry. 1985 Feb;142(2):170-4
3970241
Biol Psychiatry. 2003 Dec 1;54(11):1171-80
14643084
Am J Psychiatry. 2003 Aug;160(8):1421-7
12900303
Am J Psychiatry. 2003 Dec;160(12):2209-15
14638592
Biol Psychiatry. 2000 Jan 1;47(1):34-42
10650447
Arch Gen Psychiatry. 1987 Jul;44(7):660-9
3606332
Schizophr Res. 1999 Aug 23;39(1):19-29
10480664
Am J Hum Genet. 2004 Nov;75(5):807-21
15457404
Acta Psychiatr Scand Suppl. 1994;384:95-101
7533472
Biol Psychiatry. 2004 Aug 1;56(3):190-7
15271588
Arch Gen Psychiatry. 2002 Aug;59(8):696-701
12150645
Pharmacopsychiatry. 2001 Nov;34(6):251-3
11778146
Schizophr Res. 1995 Sep;17 (1):85-94
8541254
Am J Psychiatry. 2003 Oct;160(10):1809-16
14514495
Biol Psychiatry. 1999 May 1;45(9):1128-37
10331104
Psychiatry Res. 1986 Jul;18(3):275-84
3749386
Schizophr Res. 2004 Feb 1;66(2-3):137-42
15061245
Cereb Cortex. 2000 Nov;10(11):1078-92
11053229
Psychiatry Res. 2004 Apr 30;130(3):245-57
15135158
Arch Gen Psychiatry. 2004 Jul;61(7):658-68
15237078
Psychol Med. 1997 Jan;27(1):143-52
9122294
Arch Gen Psychiatry. 1999 Feb;56(2):155-61
10025440
Lancet. 1995 Sep 2;346(8975):596-600
7651003
Biol Psychiatry. 1999 Aug 1;46(3):312-28
10435197
Lancet. 1997 Jun 14;349(9067):1730-4
9193383
Biol Psychiatry. 2001 Jan 1;49(1):39-46
11163778
Schizophr Res. 2003 Apr 1;60(2-3):285-98
12591590
Arch Gen Psychiatry. 1999 Feb;56(2):149-54
10025439
Am J Med Genet. 2001 Jan 8;105(1):11-5
11424979
Eur Psychiatry. 1999 Mar;14(1):17-24
10572321
Psychiatry Res. 2004 Apr 30;130(3):227-43
15135157
Arch Gen Psychiatry. 1998 Dec;55(12):1097-103
9862553
Science. 1998 Oct 2;282(5386):108-11
9756472
Am J Psychiatry. 2003 Apr;160(4):709-19
12668360
Neuropsychopharmacology. 1991 Feb;4(2):145-9
1673845
Cereb Cortex. 2004 Jan;14(1):91-6
14654460
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13432-7
10557338
Nat Neurosci. 2002 Mar;5(3):267-71
11865311
J Clin Psychiatry. 2004 May;65(5):598-604
15163244
Lancet. 1993 Sep 18;342(8873):703-6
8103821
J Nerv Ment Dis. 2002 Sep;190(9):638-9
12357099
Neuroreport. 1997 Sep 8;8(13):2977-84
9376542
Schizophr Res. 2001 Mar 30;48(2-3):291-9
11295381
Br Med Bull. 2003;65:259-70
12697630
Schizophr Bull. 1999;25(2):233-55
10416729
Biol Psychiatry. 1998 Jan 15;43(2):132-8
9474445
Schizophr Res. 2002 Jan 1;53(1-2):45-56
11728837
Neuroimage. 1999 Jan;9(1):81-7
9918729
Neuron. 1999 Mar;22(3):615-21
10197540
Schizophr Res. 1991 Dec;6(1):25-30
1786233
Am J Psychiatry. 1997 Dec;154(12 ):1670-5
9396944
Rev Neurosci. 1999;10(1):49-57
10356991
Am J Psychiatry. 1997 Dec;154(12):1676-82
9396945
Am J Psychiatry. 2004 Oct;161(10 ):1798-805
15465976
Am J Psychiatry. 2002 Feb;159(2):251-4
11823267
Psychol Med. 2001 Aug;31(6):1065-78
11513374
Arch Gen Psychiatry. 2001 Mar;58(3):280-8
11231835
Arch Gen Psychiatry. 2004 Jan;61(1):34-41
14706942
Neuropsychopharmacology. 1998 Mar;18(3):186-96
9471116
Schizophr Res. 1994 Sep;13(2):133-44
7986770
Arch Gen Psychiatry. 1988 Jul;45(7):616-22
3382321
Magn Reson Imaging. 1994;12(7):975-82
7997102
Am J Psychiatry. 1981 Aug;138(8):1051-6
7258380
Arch Gen Psychiatry. 1997 May;54(5):465-72
9152100
Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4724-9
10200329
Arch Gen Psychiatry. 2003 Sep;60(9):889-96
12963670
Br J Psychiatry. 1995 Aug;167(2):197-201
7582669
Schizophr Res. 2000 Feb 14;41(3):389-95
10728716
Am J Psychiatry. 2001 Apr;158(4):646-9
11282705
Neuroimage. 2003 Jul;19(3):751-63
12880804
Am J Psychiatry. 2001 Jun;158(6):938-43
11384903
Am J Psychiatry. 2000 Aug;157(8):1309-16
10910796
Brain. 2002 Aug;125(Pt 8):1793-807
12135970
Schizophr Res. 2004 Jun 1;68(2-3):159-71
15099600
Arch Gen Psychiatry. 2002 Feb;59(2):146-53
11825136
Nat Neurosci. 2000 May;3(5):421-3
10769376
Arch Gen Psychiatry. 1997 Feb;54(2):159-65
9040284
Am J Psychiatry. 1994 Dec;151(12):1744-52
7977880
Biol Psychiatry. 2004 Mar 1;55(5):490-500
15023577