2,4,6-Trisubstituted pyrimidine derivatives as pregnancy interceptive agents.
A series of 2,4,6-trisubstituted pyrimidine derivatives was synthesized and evaluated for their in vivo pregnancy interceptive activity in hamsters. Out of the 17 compounds synthesized three compounds showed 100% activity at a dose of 10mg/kg.
Agarwal
Anu
A
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India.
Kumar
Brijesh
B
Mehrotra
Purshottam K
PK
Chauhan
Prem M S
PM
D000019:Abortifacient Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D005260:Female; D015394:Molecular Structure; D011247:Pregnancy; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000019:Abortifacient Agents; D011743:Pyrimidines; C030986:pyrimidine