How to make an egg: transcriptional regulation in oocytes.
The oocyte is a highly differentiated cell. It makes organelles specialized to its unique functions and progresses through a series of developmental stages to acquire a fertilization competent phenotype. This review will integrate the biology of the oocyte with what is known about oocyte-specific gene regulation and transcription factors involved in oocyte development. We propose that oogenesis is reliant on a dynamic gene regulatory network that includes oocyte-specific transcriptional regulators.
Song
Jia L
JL
Department of Molecular and Cell Biology and Biochemistry, Brown University, 69 Brown Street, Box G-J4, Providence, RI 02912, USA.
Wessel
Gary M
GM
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D050814:Octamer Transcription Factor-3; D009865:Oocytes / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology; D009928:Organ Specificity; D010053:Ovary / Q000254:growth & development; D010063:Ovum / Q000502:physiology*; D011247:Pregnancy; D012335:RNA, Ribosomal / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D029867:Xenopus Proteins / Q000235:genetics / Q000378:metabolism
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D050814:Octamer Transcription Factor-3; D012335:RNA, Ribosomal; D014157:Transcription Factors; D029867:Xenopus Proteins; C109920:Figla protein, mouse; C485620:GTF2A1L protein, Xenopus; C456265:Og2x protein, mouse; C494173:POU5F1 protein, human; C487976:oogenesin protein, mouse