Leuprolide acetate-induced dermatitis herpetiformis.
Dermatitis herpetiformis (DH) is a chronic, pruritic, papulovesicular dermatosis on extensor surfaces that is characterized by a neutrophilic infiltrate and granular immunoglobulin A deposition at the dermal papillae. Although the presence of immunoglobulin A in the skin and the severity of DH are known to be associated with gluten intake, few drugs have been implicated in the induction of DH. We report a case of DH triggered by intramuscular injections of leuprolide acetate, a gonadotropin-releasing hormone analog, in a patient with a history of prostate cancer.
Grimwood
Ronald E
RE
Division of Dermatology, University of Texas Health Science Center at San Antonio, TX 78229-3900, USA. grimwood@uthscsa.edu
Guevara
Adrian
A
D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D003874:Dermatitis Herpetiformis / Q000139:chemically induced*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy
D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide