title: Transglutaminase function in epidermis.
abstract: Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium. This epithelium functions to protect the organism from the environment. Transglutaminases, enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key enzymes involved in the construction of this structure. This brief review will focus on the role of these enzymes in constructing the epidermal surface.
authors.affiliation: Department of Physiology and Biophysics, Case School of Medicine, Cleveland, Ohio 44106, USA. rle2@po.cwru.edu
authors.forename: Richard L
authors.initials: RL
authors.lastname: Eckert
authors.forename: Michael T
authors.initials: MT
authors.lastname: Sturniolo
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Broome
authors.forename: Monica
authors.initials: M
authors.lastname: Ruse
authors.forename: Ellen A
authors.initials: EA
authors.lastname: Rorke
mesh_terms: D000078404:Epidermal Cells; D004817:Epidermis / Q000201:enzymology*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000201:enzymology*; D011503:Transglutaminases / Q000502:physiology*
chemical_list: D011503:Transglutaminases