Pharmacokinetics of subcutaneous selenium in adult llamas.
Selenium (Se) deficiency disease has been described in camelids and only clinical data is available for administration of parenteral Se supplements. This study investigated the pharmacokinetic effects of subcutaneous Se injection (0.1 mg/kg) in llamas fed a diet adequate in Se. Absorption of Se was rapid with peak whole blood Se concentration at the first sampling time. Significant differences in whole blood Se concentration from before injection of Se were not found past 2 days after Se injection. Parenteral Se is unlikely to have a long-term effect on whole blood Se concentration in llamas fed adequate dietary Se.
Waldridge
Bryan M
BM
Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, AL, 36849, USA.
Duran
Sue H
SH
Ravis
William R
WR
Paxton
Ralph
R
Herdt
Thomas H
TH
Pugh
David G
DG
D000042:Absorption; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D002161:Camelids, New World / Q000378:metabolism*; D004032:Diet; D019587:Dietary Supplements; D006207:Half-Life; D007263:Infusions, Parenteral / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D008297:Male; D012643:Selenium / Q000008:administration & dosage / Q000097:blood / Q000172:deficiency / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000975:Antioxidants; D012643:Selenium