title: Communesins G and H, new alkaloids from the psychrotolerant fungus Penicillium rivulum.
abstract: Communesins G (1) and H (2), two new alkaloids, have been isolated from the psychrotolerant, new species Penicillium rivulum Frisvad. The compounds were isolated by high-speed countercurrent chromatography and preparative HPLC using UV-guided fractionation. The structures were determined from 1D and 2D NMR techniques and HRESIMS. In contrast to all other known communesins, 1 and 2 were found inactive in antimicrobial, antiviral, and anticancer assays.
authors.affiliation: Marine Chemistry Section, Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark.
authors.forename: Petur W
authors.initials: PW
authors.lastname: Dalsgaard
authors.forename: John W
authors.initials: JW
authors.lastname: Blunt
authors.forename: Murray H G
authors.initials: MH
authors.lastname: Munro
authors.forename: Jens C
authors.initials: JC
authors.lastname: Frisvad
authors.forename: Carsten
authors.initials: C
authors.lastname: Christophersen
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003718:Denmark; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; C499269:communesin G; C499270:communesin H