title: Nasopharyngeal carcinoma-susceptibility locus is localized to a 132 kb segment containing HLA-A using high-resolution microsatellite mapping.
abstract: Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA-A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA-A locus in Taiwanese NPC patients. However, the pathogenic genes causing NPC susceptibility remain unknown. Here, 8 polymorphic microsatellite markers distributed over a 1 megabase region surrounding the HLA-A locus were subjected to genetic analysis for the NPC-susceptibility locus. Statistical studies of associated alleles detected on each microsatellite locus showed that the NPC- susceptibility genes are most likely located between the D6S510 and D6S211 markers within a 132 kb segment containing the HLA-A locus. These results undoubtedly would facilitate the further positional cloning of the NPC-susceptibility locus, which has been elusive for the past 30 years.
authors.affiliation: Department of Pathology, National Cheng Kung University, Tainan, Taiwan. cclu@mail.ncku.edu.tw
authors.forename: Cheng-Chan
authors.initials: CC
authors.lastname: Lu
authors.forename: Jung-Chin
authors.initials: JC
authors.lastname: Chen
authors.forename: Sen-Tien
authors.initials: ST
authors.lastname: Tsai
authors.forename: Ying-Tai
authors.initials: YT
authors.lastname: Jin
authors.forename: Jui-Chen
authors.initials: JC
authors.lastname: Tsai
authors.forename: Shih-Huang
authors.initials: SH
authors.lastname: Chan
authors.forename: Ih-Jen
authors.initials: IJ
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000235:genetics*; D013624:Taiwan
chemical_list: D015234:HLA-A Antigens