Sol-gel processing of drug delivery materials and release kinetics.
Silica, calcium (5 mol%) silicate and silica/polycaprolactone hybrid inorganic/organic amorphous materials, all mixed with sodium ampicillin, a broad-spectrum antibiotic, have been synthesized by sol-gel method. The amorphous nature of the gels was ascertained by X-ray diffraction analysis. Release kinetics in a simulate body fluid (SBF) have been subsequently investigated. The amount of sodium ampicillin released has been detected by UV-Vis spectroscopy and SEM. The release kinetics seems to occur in more than one stage. Finally FTIR measurements and SEM micrograph showed the formation of a hydroxyapatite layer on the surface of the samples soaked in SBF. All data showed that these materials could be used as drug delivery bioactive systems.
De Gaetano
F
F
Department of Materials and Productions Engineering, University of Naples, Federico II Piazzale Tecchio, 80125 Naples, Italy.
Ambrosio
L
L
Raucci
M G
MG
Marotta
A
A
Catauro
M
M
D000667:Ampicillin / Q000737:chemistry / Q000493:pharmacokinetics*; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids; D017610:Calcium Compounds / Q000737:chemistry; D016503:Drug Delivery Systems; D005782:Gels / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D017640:Silicates / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013499:Surface Properties; D013997:Time Factors; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D017610:Calcium Compounds; D005782:Gels; D007783:Lactones; D017640:Silicates; D012822:Silicon Dioxide; D000667:Ampicillin; C031293:calcium silicate
J AOAC Int. 1998 Mar-Apr;81(2):381-5
9549072
J Periodontol. 1990 Jul;61(7):393-8
2388137
J Bone Joint Surg Br. 1992 Jul;74(4):600-4
1320622
J Biomed Mater Res. 2000 Sep 5;51(3):424-9
10880085
J Clin Periodontol. 1994 May;21(5):351-5
8034781