Acetylation genotype and the genetic susceptibility to prostate cancer in a southern European population.
BACKGROUND
Epidemiologic studies have suggested that environmental factors and diet are important risk factors in the pathogenesis of prostate cancer. The N-acetyltransferases (NAT) are important enzymes in activation and inactivation of various carcinogens, including those found in well-cooked meat and cigarette smoke.


METHODS
We analyzed DNA samples from 146 prostate cancer patients and 174 healthy men. We used PCR-RFLP method to analyze NAT 1 and NAT 2 polymorphisms.


RESULTS
We did not find statistically significant differences in NAT 1 genotypes frequencies between prostate cancer patients and control group. We observed an association of the slow acetylator genotype, NAT 2*6/NAT2*6 with prostate cancer protection (P=0.017; OR=0.31, 95% CI 0.11--0.84). Multivariate logistic regression analysis confirmed this association (0.030; OR=0.32, 95% CI 0.12--0.89).


CONCLUSIONS
Our results indicate a role of NAT2 polymorphisms in the carcinogenic pathway of prostate cancer, specifically in a population of Southern Europe.
Costa
Sandra
S
ICVS, Life and Health Sciences Research Institute, Health Science School, Minho University, Braga, Portugal. sandracosta@portugalmail.com
Pinto
Daniela
D
Morais
Antonio
A
Vasconcelos
André
A
Oliveira
Jorge
J
Lopes
Carlos
C
Medeiros
Rui
R
D000107:Acetylation; D000368:Aged; D001191:Arylamine N-Acetyltransferase / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D007527:Isoenzymes; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011174:Portugal / Q000453:epidemiology; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors
D007527:Isoenzymes; D001191:Arylamine N-Acetyltransferase; C089384:N-acetyltransferase 1; C478900:NAT2 protein, human