[Imbalance between pro-oxidative and anti-oxidative processes in children with neoplastic disease].
THE AIM of the study was to assess the concentration of malondialdehyde (MDA), vitamin E and total antioxidant status (TAS) of serum and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in erythrocytes.


METHODS
a total of 56 children, aged 1,5-18 years, treated between 2001-2002, were diagnosed as having malignant disease. Of these, 27 patients had leukemia, 20 had solid tumours and 9 -lymphoma. These patients were examined before treatment and on achieving remission during therapy.


RESULTS
the imbalance between pro-oxidative and antioxidative processes were found in all the children with neoplastic disease. TAS was lower and GPX was higher than normal in all children with cancer; MDA was higher in the newly diagnosed children before treatment.


CONCLUSIONS
the role of vitamin E in the pathogenesis of childhood neoplastic disease need to be evaluated. Further studies on a larger group of patients are needed.
Drabko
Katarzyna
K
Department of Peadiatric Haematology and Oncology, Medical University, Chodźki 2 St., Lublin, Poland.
Kowalczyk
Jerzy
J
D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007223:Infant; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D012189:Retrospective Studies; D013482:Superoxide Dismutase / Q000097:blood*; D013997:Time Factors; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase