Environmental strains of Cryptococcus neoformans variety grubii in the city of Santos, SP, Brazil.
This study involved a total of 116 samples, 79 taken from pigeon droppings and 37 of atmospheric air taken close to accumulations of excrement. Cryptococcus neoformans var. grubii was isolated from 11 (13.9%) of these samples. Other species of Cryptococcus were also isolated from these samples, such as C. albidus (12.6%) and C. laurentii (8.9%). C. neoformans was not isolated from the air samples, though C. albidus (5.4%) was. All the strains of C. neoformans were found to belong to the A serotype (C. neoformans var. grubii). In regard to the studies with the antifungal agents 5-fluorocytosine, fluconazole, itraconazole, amphotericin B and voriconazole, by means of the microdilution method (EUCAST), we point out that one sample demonstrated resistance to fluconazole, this being especially significant because this is an environmental strain.
Soares
Maria Cecília Bianchi
MC
Microbiology and Immunology Section, Adolfo Lutz Institute, Santos, São Paulo, Brazil.
Paula
Claudete Rodrigues
CR
Dias
Amanda L T
AL
Caseiro
Marcos Montani
MM
Costa
Sérgio Olavo Pinto da
SO
D000391:Air Microbiology; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001938:Brazil; D010856:Columbidae; D003455:Cryptococcus neoformans / Q000187:drug effects / Q000302:isolation & purification*; D005243:Feces / Q000382:microbiology*; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents