title: Icodextrin re-absorption varies with age in children on automated peritoneal dialysis.
abstract: Information on the use of Icodextrin in children remains scarce; however, it is believed that the characteristics are similar across all ages. We report the use of Icodextrin in a cohort of pediatric automated peritoneal dialysis (APD) patients younger than those previously reported (n=8, median age of 2.8, range 0.02-17.1 years). Net Icodextrin daytime dwell ultrafiltration was calculated in each patient for every day on therapy as ml/h/m2. Half of the patients showed re-absorption even when reducing Icodextrin dwells from a median of 10 to 6 h. All four patients who re-absorbed the Icodextrin (ranging from -23.7+/-7.5 to -2.5+/-6.0 ml/h/m2) were treated with cyclic nocturnal APD, and three of these four patients were high transporters on the peritoneal equilibration test (PET). Icodextrin fluid removal correlated significantly with age (Spearman rank r=0.8571, P=0.0107). The data suggest that Icodextrin behaves differently in young children.
authors.affiliation: Department of Pediatrics, Division of Nephrology, Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada.
authors.forename: Allison
authors.initials: A
authors.lastname: Dart
authors.forename: Janusz
authors.initials: J
authors.lastname: Feber
authors.forename: Hubert
authors.initials: H
authors.lastname: Wong
authors.forename: Guido
authors.initials: G
authors.lastname: Filler
mesh_terms: D000042:Absorption; D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015314:Dialysis Solutions / Q000493:pharmacokinetics*; D005260:Female; D005936:Glucans / Q000493:pharmacokinetics*; D005947:Glucose / Q000493:pharmacokinetics*; D006801:Humans; D000077607:Icodextrin; D007223:Infant; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D010530:Peritoneal Dialysis / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D015314:Dialysis Solutions; D005936:Glucans; D000077607:Icodextrin; D005947:Glucose
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