Evidence for a hydrogen abstraction mechanism in P450-catalyzed N-dealkylations.
The experimental evidence presented in this manuscript suggest against the widely accepted single electron/proton transfer mechanism for P450 catalyzed N-dealkylations and provides strong support for a hydrogen atom abstraction mechanism.
Bhakta
Mehul
M
Department of Chemistry, Wichita State University, Wichita, Kansas 67260, USA.
Hollenberg
Paul F
PF
Wimalasena
Kandatege
K
D000478:Alkylation; D000818:Animals; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000378:metabolism*; D004583:Electrons; D006859:Hydrogen / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D011522:Protons; D051381:Rats
D011522:Protons; D006859:Hydrogen; D003577:Cytochrome P-450 Enzyme System