Telomerase activity in cells of 9-day-old spleen colonies formed by bone marrow of normal and thymectomized mice.
Telomerase activity was measured in spleen colonies, in progeny of individual 9-day-old splenic CFU formed by the bone marrow from normal (physiological aging) and thymectomized mice. Cells of spleen colonies expressed telomerase activity. No correlation was found between telomerase activity in spleen colony cells and age of animals. Thymectomy of bone marrow donors had no effect on telomerase activity. Our results suggest that the thymus plays a role in cell aging.
Todriya
T V
TV
Hematological Research Center, Moscow, Russia. todria@blood.ru
Tzander
A
A
D000328:Adult; D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001854:Bone Marrow Cells / Q000166:cytology / Q000201:enzymology*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012016:Reference Values; D013154:Spleen / Q000201:enzymology*; D019098:Telomerase / Q000378:metabolism*; D013934:Thymectomy
D019098:Telomerase