Procoagulant potential of platelet alpha granules.
In this brief review of the literature it is pointed out that during platelet activation and degranulation platelet alpha granules leave the platelet interior through blebs in platelet plasma membrane and through the tips of the pseudopods, and then accumulate in the external milieu. There they undergo disintegration and secondary adhesion to the platelet plasma membranes. During their disintegration they expose their tightly packed GPIIb-IIIa complexes, annexin V stainable aminophospholipids, factor V, and the membrane markers CD62 and CD63. There is also demasking of lysosomal acid phosphatase activity and microvesicle formation. Lysosomal nature of platelet alpha granules is mentioned. It is suggested that platelet alpha granules are the sole source of platelet procoagulant activity and platelet microparticles (MP) or microvesicles (MV). The implications of this concept for antiplatelet therapy are discussed. A relationship of this process to tissue factor exposure and apoptosis is suggested.
Polasek
J
J
William Osler Health Center, Etobicoke Hospital Campus, Toronto, Canada. polasekj@canada.com
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000502:physiology* / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000502:physiology*; D006801:Humans; D015539:Platelet Activation / Q000502:physiology*