title: Modulation of the notch pathway for immunotherapy.
abstract: Since its initial description as a neurogenic locus in Drosophila, the Notch pathway has been shown to play a central role in cell fate decisions across species, including vertebrates, guiding the differentiation of multiple cell types. In the immune system, its function was first demonstrated during lymphopoiesis, but in recent years this pathway has been shown to still be active in peripheral T-cells. Therapeutic opportunities that could arise from the manipulation of Notch signaling in immune disorders such as autoimmunity, allergy and in cancer immunotherapy and transplantation are discussed.
authors.affiliation: Lorantis Ltd, Cambridge, UK. emmanuel.briend@lorantis.com
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Briend
authors.forename: Lesley L
authors.initials: LL
authors.lastname: Young
authors.forename: Grahame J
authors.initials: GJ
authors.lastname: McKenzie
authors.forename: Tamara
authors.initials: T
authors.lastname: Tugal
authors.forename: Silvia
authors.initials: S
authors.lastname: Ragno
authors.forename: Brian R
authors.initials: BR
authors.lastname: Champion
mesh_terms: D000818:Animals; D004247:DNA; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000276:immunology; D007167:Immunotherapy; D008024:Ligands; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology / Q000502:physiology* / Q000627:therapeutic use; D051880:Receptors, Notch; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D014612:Vaccines / Q000276:immunology / Q000627:therapeutic use
chemical_list: D008024:Ligands; D008565:Membrane Proteins; D051880:Receptors, Notch; D014612:Vaccines; D004247:DNA