title: Paradoxical response to antituberculous therapy in infliximab-treated patients with disseminated tuberculosis.
abstract: Six of 284 patients treated with infliximab developed active tuberculosis. Four (67%) of these patients had a paradoxical response to antituberculous therapy. Physicians should be aware of the increased risk of a paradoxical response in this population and should consider the use of corticosteroids when a paradoxical reaction is suspected.
authors.affiliation: Service of Internal Medicine, Hospital Mutua de Terrassa, University of Barcelona, Barcelona, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Garcia Vidal
authors.forename: Serena
authors.initials: S
authors.lastname: Rodríguez Fernández
authors.forename: Javier
authors.initials: J
authors.lastname: Martínez Lacasa
authors.forename: Miquel
authors.initials: M
authors.lastname: Salavert
authors.forename: Rafael
authors.initials: R
authors.lastname: Vidal
authors.forename: Monica
authors.initials: M
authors.lastname: Rodríguez Carballeira
authors.forename: Javier
authors.initials: J
authors.lastname: Garau
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013167:Spondylitis, Ankylosing / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000911:Antibodies, Monoclonal; D000995:Antitubercular Agents; D007166:Immunosuppressive Agents; D000069285:Infliximab