title: Equisetin biosynthesis in Fusarium heterosporum.
abstract: An iterative polyketide synthase-peptide synthetase hybrid assembles the HIV-1 integrase inhibitory tetramic acid, equisetin, in the filamentous fungus Fusarium heterosporum.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, 30 South 2000 East Rm 201, Salt Lake City, UT 84112, USA.
authors.forename: James W
authors.initials: JW
authors.lastname: Sims
authors.forename: John P
authors.initials: JP
authors.lastname: Fillmore
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Warner
authors.forename: Eric W
authors.initials: EW
authors.lastname: Schmidt
mesh_terms: D005670:Fusarium / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D017353:Gene Deletion; D005800:Genes, Fungal; D015394:Molecular Structure; D005810:Multigene Family; D011760:Pyrrolidinones / Q000737:chemistry / Q000378:metabolism*; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes; C024509:equisetin