Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo.
Clinical intervention studies and experimental studies with lignan-rich diets suggest that lignans may have inhibitory effects on prostate cancer, but no clinical or experimental studies with purified lignans have been published. The purpose of this study was to investigate the effect of a plant lignan 7-hydroxymatairesinol (HMR) on LNCaP human prostate cancer xenografts in athymic mice. Athymic nude male mice were injected subcutaneously with LNCaP cells. Starting 3 days after tumor cell injections, a control diet or a control diet supplemented with 0.15% or 0.30% of HMR was administered to mice and the tumor take rate and growth was observed for 9 weeks. HMR diet inhibited the growth of LNCaP tumors. Mice treated with HMR had smaller tumor volume, lower tumor take rate, increased proportion of nongrowing tumors, and higher tumor cell apoptotic index compared with controls. Furthermore, the cell proliferation index was reduced in mice receiving the 0.30% HMR diet compared with mice receiving the control diet. Our results suggest that dietary HMR started at the early phase of the tumor development inhibits the growth of the LNCaP human prostate cancer xenografts in athymic male mice.
Bylund
Annika
A
University of Turku, Functional Foods Forum, FI-20014 Turku, Finland.
Saarinen
Niina
N
Zhang
Jie-Xian
JX
Bergh
Anders
A
Widmark
Anders
A
Johansson
Anders
A
Lundin
Eva
E
Adlercreutz
Herman
H
Hallmans
Göran
G
Stattin
Pär
P
Mäkela
Sari
S
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D002277:Carcinoma / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D004032:Diet; D004195:Disease Models, Animal; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008954:Models, Biological; D009368:Neoplasm Transplantation; D048789:Phytoestrogens / Q000378:metabolism / Q000652:urine; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays
D016588:Anticarcinogenic Agents; D007529:Isoflavones; D017705:Lignans; D048789:Phytoestrogens; C419306:hydroxymatairesinol; D017430:Prostate-Specific Antigen