title: Airborne chemicals cause respiratory symptoms in individuals with contact allergy.
abstract: Exposure to fragrance chemicals causes various eye and airway symptoms. Individuals with perfume contact allergy report these symptoms more frequently than individuals with nickel allergy or no contact allergies. However, the associations between contact allergy and respiratory symptoms elicited by airborne chemicals other than perfumes are unclear. The study aimed to investigate the association between eye and airway symptoms elicited by airborne chemicals (other than perfumes) and contact allergy in a population-based sample. A questionnaire on respiratory symptoms was posted, in 2002, to 1189 individuals who participated in 1997/1998 in a Danish population-based study of allergic diseases. Questions about eye and airway symptoms elicited by different airborne chemicals and airborne proteins were included in the questionnaire. Data from the questionnaire were compared with data on patch testing and prick testing. Having at least 1 positive patch test (adjusted odds ratio 1.7, 95% CI 1.2-2.5) was associated with the symptoms, and the odds ratio increased with the number of positive patch tests (P-value for test for trend <0.05). Bronchial hyperreactivity, female sex and psychological vulnerability were independently associated with symptoms, but no association was found between prick test reactivity to proteins and the symptoms elicited by airborne chemicals.
authors.affiliation: The National Allergy Research Centre, Department of Dermatology, Gentofte University Hospital, Gentofte, Denmark. jeel@gentoftehosp.kbhamt.dk
authors.forename: J
authors.initials: J
authors.lastname: Elberling
authors.forename: A
authors.initials: A
authors.lastname: Linneberg
authors.forename: H
authors.initials: H
authors.lastname: Mosbech
authors.forename: A
authors.initials: A
authors.lastname: Dirksen
authors.forename: T
authors.initials: T
authors.lastname: Menné
authors.forename: N H
authors.initials: NH
authors.lastname: Nielsen
authors.forename: F
authors.initials: F
authors.lastname: Madsen
authors.forename: L
authors.initials: L
authors.lastname: Frølund
authors.forename: J Duus
authors.initials: JD
authors.lastname: Johansen
mesh_terms: D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects*; D000485:Allergens / Q000009:adverse effects*; D016535:Bronchial Hyperreactivity / Q000139:chemically induced / Q000453:epidemiology / Q000473:pathology; D003233:Conjunctivitis, Allergic / Q000139:chemically induced / Q000453:epidemiology / Q000473:pathology; D003718:Denmark / Q000453:epidemiology; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D005260:Female; D006229:Hand Dermatoses / Q000139:chemically induced / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D012882:Skin Tests / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires
chemical_list: D000393:Air Pollutants; D000485:Allergens