Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis.
To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.
Al-Shanqeeti
Ali
A
Division of Haematology, Washington University, St. Louis, Missouri 63110-1093, USA. gbroze@im.wustl.edu
van Hylckama Vlieg
Astrid
A
Berntorp
Erik
E
Rosendaal
Frits R
FR
Broze
George J
GJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000032:analysis* / Q000187:drug effects / Q000502:physiology; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015843:Serpins / Q000097:blood* / Q000187:drug effects / Q000502:physiology; D020246:Venous Thrombosis / Q000097:blood* / Q000209:etiology; D014859:Warfarin / Q000494:pharmacology / Q000627:therapeutic use
D001798:Blood Proteins; D003276:Contraceptives, Oral; C416370:SERPINA10 protein, human; D015843:Serpins; C026080:plasma protein Z; D014859:Warfarin