Dishevelled and Wnt signaling: is the nucleus the final frontier?
The phosphoprotein Dishevelled (Dsh) is an essential component of Wnt signaling pathways and transduces signals into three separate branches, the canonical, non-canonical and Ca2+ pathways. How Dsh focuses signaling into these branches remains mysterious, but a new study reveals the importance of nuclear localization of Dsh for pathway-specific activation.
Habas
Raymond
R
Cancer Institute of New Jersey and Department of Biochemistry, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Dawid
Igor B
IB
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002467:Cell Nucleus / Q000502:physiology; D000072261:Dishevelled Proteins; D006801:Humans; D008024:Ligands; D009685:Nuclear Envelope / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000235:genetics / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D008024:Ligands; D010750:Phosphoproteins; D051153:Wnt Proteins
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