[FISH detection of spontaneous level of chromosome aberrations in peripheral blood lymphocytes in persons of different ages].
FISH-WCP method with fluorescent probes to chromosomes 1, 2, 4 was used for cytogenetical examination of two groups of male (middle age 23 and 53.5 years) who deny their deliberate contact with known or supposed mutagens. The wide inter-individual variability of the stable chromosome aberration frequencies in each group has been shown (0.006-0.014 and 0.006-0.025 per cell per genome-equivalent correspondingly). The trend of increasing of the mean-group level of one-way and two-way translocations during aging has been revealed (0.009 and 0.013 per cell per genome-equivalent, correspondingly).
Pilins'ka
M A
MA
Dybs'kyĭ
S S
SS
D000328:Adult; D000375:Aging / Q000235:genetics*; D002869:Chromosome Aberrations; D020223:Chromosome Painting; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic / Q000235:genetics