title: Efg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicans.
abstract: The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1/cph1 efg1/efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3. Mutations in EFG1 consistently increased the susceptibility of the cells to antifungal agents.
authors.affiliation: Division of Clinical Research, National Health Research Institutes, Taipei, Taiwan, Republic of China.
authors.forename: Hsiu-Jung
authors.initials: HJ
authors.lastname: Lo
authors.forename: Jang-Shiun
authors.initials: JS
authors.lastname: Wang
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Lin
authors.forename: Chia-Geun
authors.initials: CG
authors.lastname: Chen
authors.forename: Ting-Yin
authors.initials: TY
authors.lastname: Hsiao
authors.forename: Chia-Tung
authors.initials: CT
authors.lastname: Hsu
authors.forename: Chia-Li
authors.initials: CL
authors.lastname: Su
authors.forename: Ming-Ji
authors.initials: MJ
authors.lastname: Fann
authors.forename: Yu-Tai
authors.initials: YT
authors.lastname: Ching
authors.forename: Yun-Liang
authors.initials: YL
authors.lastname: Yang
mesh_terms: D002176:Candida albicans / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D004268:DNA-Binding Proteins / Q000502:physiology*; D025141:Drug Resistance, Fungal; D005656:Fungal Proteins / Q000502:physiology*; D015966:Gene Expression Regulation, Fungal; D010088:Oxidoreductases / Q000235:genetics*; D014157:Transcription Factors / Q000502:physiology*; D014774:Virulence
chemical_list: D004268:DNA-Binding Proteins; C121438:EFG1 protein, Candida albicans; D005656:Fungal Proteins; D014157:Transcription Factors; D010088:Oxidoreductases; C039306:sterol delta-5 desaturase
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