title: Antitumor metallothiosemicarbazonates: structure and antitumor activity of palladium complex of phenanthrenequinone thiosemicarbazone.
abstract: The crystal structure of the potential antitumor metal compound, viz. chloro, mono(phenanthrenequinone thiosemicarbazonato) palladium(II) dimethyl formamide solvate, is reported. The central palladium(II) atom is in a square planar environment provided by the tridentate, monoanionic thiosemicarbazone ligand and the ancillary chloride ion. The compound exhibited remarkable activity against drug-sensitive and drug-resistant breast cancer cell lines and was relatively nontoxic toward the normal mammary epithelial cells. The drug-induced killing effect against breast cancer cell lines was predominantly mediated via apoptosis, a physiologic form of cell death.
authors.affiliation: Karmanos Cancer Research Institute, School of Medicine, 9374 Scott Hall, Wayne State University, Detroit, Michigan 48201, USA. sbpadhye@chem.unipune.ernet.in
authors.forename: Subhash
authors.initials: S
authors.lastname: Padhye
authors.forename: Zahra
authors.initials: Z
authors.lastname: Afrasiabi
authors.forename: Ekk
authors.initials: E
authors.lastname: Sinn
authors.forename: Jansina
authors.initials: J
authors.lastname: Fok
authors.forename: Kapil
authors.initials: K
authors.lastname: Mehta
authors.forename: Nigam
authors.initials: N
authors.lastname: Rath
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D010616:Phenanthrenes / Q000737:chemistry* / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010616:Phenanthrenes; D013882:Thiosemicarbazones; C479020:phenanthrenequinone thiosemicarbazone