title: Explainable and critical periods during human dental morphogenesis and their control.
abstract: OBJECTIVE
  To what extent is the current knowledge about regulatory and patterning processes gained from research on animal models (predominantly mouse) applicable to describe certain aspect of human prenatal dental development?
  
  
  METHODS
  3D-reconstructions were produced from serial sections of human dental primordia (Radlanski collection, Berlin) and scanning electron microscopic visualisation techniques were applied.
  
  
  CONCLUSIONS
  There are several examples, where present knowledge of regulatory processes allows the understanding of changes in outline and form. However, many other examples show that much more complex regulatory mechanisms should be expected to explain the details of human prenatal dental development.
authors.affiliation: Charité, Campus Benjamin, Franklin at Freie Universität Berlin, Klinik und Poliklinik, für Zahn-, Mund- und Kieferheilkunde, Department of Experimental Dentistry and Oral Structural Biology, D-14197 Berlin-Wilmersdorf, Germany. ralfj.radlanski@charite.de
authors.forename: Ralf J
authors.initials: RJ
authors.lastname: Radlanski
authors.forename: Herbert
authors.initials: H
authors.lastname: Renz
mesh_terms: D003196:Computer Graphics; D003724:Dental Arch / Q000648:ultrastructure; D004658:Enamel Organ / Q000648:ultrastructure; D006801:Humans; D021621:Imaging, Three-Dimensional; D007180:Incisor / Q000196:embryology*; D008855:Microscopy, Electron, Scanning; D008963:Molar / Q000196:embryology*; D009805:Odontogenesis / Q000502:physiology*