title: Multicentric pleomorphic xanthoastrocytoma in a patient with neurofibromatosis type 1. Case report and review of the literature.
abstract: The authors report an unusual case of multicentric pleomorphic xanthoastrocytoma (PXA) in a 36-year-old woman with neurofibromatosis Type 1 (NF1). Both lesions were diagnosed as PXA but demonstrated different neuroimaging features and very different outcomes. Although the occipital lesion was cured surgically, the cerebellar tumor recurred three times and underwent malignant transformation into an anaplastic oligodendroglioma. The authors discuss the causes of PXA and suggest that it could originate from common bipotential precursor cells with two phenotypes.
authors.affiliation: Department of Pathology, Centre Hospitalier Régional et Universitaire Pontchaillou, Rennes, France.
authors.forename: Stephan
authors.initials: S
authors.lastname: Saikali
authors.forename: Anne
authors.initials: A
authors.lastname: Le Strat
authors.forename: Anne
authors.initials: A
authors.lastname: Heckly
authors.forename: Nathalie
authors.initials: N
authors.lastname: Stock
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Scarabin
authors.forename: Abderrahmane
authors.initials: A
authors.lastname: Hamlat
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000473:pathology / Q000601:surgery*; D001921:Brain / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000473:pathology / Q000601:surgery; D002531:Cerebellum / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery*; D009456:Neurofibromatosis 1 / Q000473:pathology / Q000601:surgery*; D009778:Occipital Lobe / Q000473:pathology / Q000601:surgery; D009837:Oligodendroglioma / Q000473:pathology