title: Resistance of multidrug-resistant strains of Mycobacterium tuberculosis from the Archangel oblast, Russia, to second-line anti-tuberculosis drugs.
abstract: Multidrug-resistant tuberculosis has become common all over the world, necessitating the inclusion of second-line drugs in treatment regimens. In the present study, the susceptibility of a selection of multidrug-resistant strains of Mycobacterium tuberculosis isolated in the Archangel oblast, Russia, to second-line anti-tuberculosis drugs was analysed. Susceptibility testing of 77 Mycobacterium tuberculosis strains was performed by the Bactec method using the following recommended drug concentrations: capreomycin 1.25 microg/ml; ethionamide 1.25 microg/ml; kanamycin 5 microg/ml; and ofloxacin 2 microg/ml. The majority of strains (92.2%) were resistant to ethionamide. High rates of drug resistance were also found for capreomycin (42.9%) and kanamycin (41.6%), while nearly all strains (98.7%) were susceptible to ofloxacin. The high rates of resistance to ethionamide, capreomycin, and kanamycin show the real burden of drug resistance in the region and pose a serious problem for the treatment of patients with multidrug-resistant tuberculosis.
authors.affiliation: Department of General Practice and Community Medicine, Faculty of Medicine, University of Oslo, P.O. Box 1130, Blindern, 0317, Oslo, Norway. o.s.toungoussova@samfunnsmed.uio.no
authors.forename: O S
authors.initials: OS
authors.lastname: Toungoussova
authors.forename: A O
authors.initials: AO
authors.lastname: Mariandyshev
authors.forename: G
authors.initials: G
authors.lastname: Bjune
authors.forename: D A
authors.initials: DA
authors.lastname: Caugant
authors.forename: P
authors.initials: P
authors.lastname: Sandven
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D002207:Capreomycin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D005000:Ethionamide / Q000494:pharmacology; D006801:Humans; D007612:Kanamycin / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D015242:Ofloxacin / Q000494:pharmacology; D012426:Russia; D014397:Tuberculosis, Pulmonary / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D002207:Capreomycin; D007612:Kanamycin; D015242:Ofloxacin; D005000:Ethionamide
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