title: Development of hypoxemia in alcoholic liver disease.
abstract: The aim of this study was to investigate the arterial hypoxemia in Japanese patients with alcoholic liver disease (ALD) with regard to alcohol consumption and/or disease severity. Hypoxemia was observed in 78% patients with ALD and in all 46 patients with alcoholic liver cirrhosis (ALC) and 33 (56%) of 59 patients with noncirrhotic alcoholic liver disease (NCALD) (P < 0.0001). The partial pressure of oxygen (PaO2) was 71.1 +/- 5.2 mm Hg in ALC and 78.7 +/- 6.3 mm Hg in NCALD (P < 0.0001). The oxygen consumption in ALD was significantly higher than that in control subjects (P < 0.0001), and a high oxygen consumption was seen in 88% of the patients with ALD, in all 46 ALC patients, and in 46 (78%) of 59 NCALD patients (P < 0.01). Following abstinence from alcohol, the PaO2 and oxygen consumption significantly recovered after day 2 (P < 0.0001), whereas the prothrombin index did not change in either NCALD or ALC patients. Multivariate analysis showed that alcohol consumption and oxygen consumption were significant independent predictors of PaO2. In conclusion, the present findings suggest that increased oxygen consumption due to alcohol ingestion is principally responsible for the hypoxemia in ALD patients.
authors.affiliation: Department of Gastroenterology, Saiseikai Gotsu General Hospital, Gotsu, 695, Shimane, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Maruyama
authors.forename: Chisato
authors.initials: C
authors.lastname: Hirayama
authors.forename: Kazunori
authors.initials: K
authors.lastname: Maeda
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Masaharu
authors.initials: M
authors.lastname: Koda
authors.forename: Akihide
authors.initials: A
authors.lastname: Udagawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Inoue
authors.forename: Kensuke
authors.initials: K
authors.lastname: Umeki
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D005235:Fatty Liver, Alcoholic / Q000097:blood / Q000503:physiopathology; D005260:Female; D006505:Hepatitis / Q000097:blood / Q000503:physiopathology; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000097:blood / Q000503:physiopathology; D008108:Liver Diseases, Alcoholic / Q000097:blood* / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption
chemical_list: D010100:Oxygen
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