title: Comparison of relative forced expiratory volume of one second with dynamic magnetic resonance imaging parameters in healthy subjects and patients with lung cancer.
abstract: OBJECTIVE
  To assess relative forced expiratory volume in one second (FEV1/vital capacity (VC)) in healthy subjects and patients with a lung tumor using dynamic magnetic resonance imaging (dMRI) parameters.
  
  
  METHODS
  In 15 healthy volunteers and 31 patients with a non-small-cell lung carcinoma stage I (NSCLC I), diaphragmatic length change (LE1) and craniocaudal (CC) intrathoracic distance change within one second from maximal inspiration (DE1) were divided by total length change (LE(total), DE(total)) as a surrogate of spirometric FEV1/VC using a true fast imaging with steady-state precession (trueFISP) sequence (TE/TR = 1.7/37.3 msec, temporal resolution = 3 images/second). Influence of tumor localization was examined.
  
  
  RESULTS
  In healthy volunteers FEV1/VC showed a highly significant correlation with LE1/LE(total) and DE1/DE(total) (r > 0.9, P < 0.01). In stage IB tumor patients, comparing tumor-bearing with the non-tumor-bearing hemithorax, there was a significant difference in tumors of the middle (LE1/LE(total) = 0.63 +/- 0.05 vs. 0.73 +/- 0.04, DE1/DE(total) = 0.66 +/- 0.05 vs. 0.72 +/- 0.04; P < 0.05) and lower (P < 0.05) lung region. Stage IA tumor patients showed no significant differences with regard to healthy subjects.
  
  
  CONCLUSIONS
  dMRI is a simple noninvasive method to locally determine LE1/LE(total) and DE1/DE(total) as a surrogate of FEV1/VC in volunteers and patients. Tumors of the middle and lower lung regions have a significant influence on these MRI parameters.
authors.affiliation: Department of Radiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany. c.plathow@dkfz.de
authors.forename: Christian
authors.initials: C
authors.lastname: Plathow
authors.forename: Christian
authors.initials: C
authors.lastname: Fink
authors.forename: Alexandra
authors.initials: A
authors.lastname: Sandner
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ley
authors.forename: Michael
authors.initials: M
authors.lastname: Puderbach
authors.forename: Monika
authors.initials: M
authors.lastname: Eichinger
authors.forename: Astrid
authors.initials: A
authors.lastname: Schmähl
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001837:Body Weights and Measures / Q000379:methods; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000503:physiopathology*; D003964:Diaphragm / Q000502:physiology / Q000503:physiopathology; D005240:Feasibility Studies; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012123:Pulmonary Ventilation / Q000502:physiology; D012016:Reference Values; D013147:Spirometry / Q000379:methods; D013909:Thorax / Q000502:physiology / Q000503:physiopathology; D013997:Time Factors