Diastereoselective aldol additions to alpha-amino-beta-silyloxy aldehydes. Divergent synthesis of aminodiols.
A divergent protocol for substrate-controlled diastereoselective synthesis of aminodiols has been developed using nucleophilic Mukaiyama aldol additions to alpha-amino-beta-silyloxy aldehydes. The merged stereochemical impact on the diastereoselectivity of the polar alpha- and beta-substituents is highlighted. [reaction: see text]
Restorp
Per
P
KTH Chemistry, Organic Chemistry, SE-100 44 Stockholm, Sweden.
Somfai
Peter
P