Phyllodes tumors of the breast: the role of pathologic parameters.
We aimed to establish whether morphologic parameters were prognostically important in a large series of breast phyllodes tumors in Asian women. Of 335 phyllodes tumors diagnosed at the Department of Pathology, Singapore General Hospital, Singapore, between January 1992 and December 2002, 250 (74.6%) were benign, 54 (16.1%) borderline, and 31 (9.3%) malignant, based on histologic review of archival slides. Of the women, 43 (12.8%) experienced recurrences during the follow-up period. Recurrent disease was correlated with grade or classification (P = .028), stromal atypia (P = .016), stromal hypercellularity (P = .046), and permeative microscopic borders (P = .021). Multivariate analysis revealed that independent predictors of recurrence were pseudoangiomatous stromal hyperplasia (PASH) and margin status, whereby the presence of PASH and complete or negative margins reduced recurrence hazards by 51.3% and 51.7% respectively. The 7 women who died of disease during follow-up had malignant phyllodes tumor at the outset and experienced recurrences, and death was preceded by distant metastases.
Tan
Puay-Hoon
PH
Department of Pathology, Singapore General Hospital, Singapore.
Jayabaskar
Thiyagarajan
T
Chuah
Khoon-Leong
KL
Lee
Hwei-Yee
HY
Tan
Yen
Y
Hilmy
Maryam
M
Hung
Huynh
H
Selvarajan
Sathiyamoorthy
S
Bay
Boon-Huat
BH
D000293:Adolescent; D000368:Aged; D001208:Asia; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D049669:History, 16th Century; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology; D003557:Phyllodes Tumor / Q000473:pathology*; D011379:Prognosis