False-positive Histoplasma capsulatum Gen-Probe chemiluminescent test result caused by a Chrysosporium species.
We describe a case in which the Histoplasma capsulatum AccuProbe test displayed cross-reactivity with a respiratory isolate thought to be Histoplasma but not morphologically consistent with H. capsulatum. The isolate was later identified as the Chrysosporium anamorph of Nannizziopsis vriesii by sequence analysis and phenotypic data.
Brandt
Mary E
ME
Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop G-11, Atlanta, GA 30333, USA. mbb4@cdc.gov
Gaunt
Dennis
D
Iqbal
Naureen
N
McClinton
Shirley
S
Hambleton
Sarah
S
Sigler
Lynne
L
D000328:Adult; D001483:Base Sequence; D002912:Chrysosporium / Q000302:isolation & purification*; D005189:False Positive Reactions; D006658:Histoplasma / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008969:Molecular Sequence Data; D010641:Phenotype; D017422:Sequence Analysis, DNA