The effect of age on vitamin E status, metabolism, and function: metabolism as assessed by labeled tocopherols.
The effects of age on vitamin E metabolism were studied in 97 healthy 20-75-year-old male nonsmoking Austrian volunteers of the VITAGE project. After a single oral intake of 30 mg d(6)-RRR-alpha- and d(2)-RRR-gamma-tocopheryl acetate, blood and 24-hour urine was collected. Deuterated tocopherols in plasma and deuterated urinary metabolites were analyzed by GC-MS. A first evaluation revealed a similar uptake of d(6)-alpha- and d(2)-gamma-tocopherol during the first 6 hours, and then d(2)-gamma-tocopherol started to decrease. Urinary d(2)-gamma- carboxyethyl hydroxychroman metabolites (CEHCs) exceeded those of d(6)-alpha-CEHCs by about 10 times. There was no effect of age. Thus, there might be no need for a higher vitamin E intake for healthy elderly nonsmoking men.
Brigelius-Flohé
Regina
R
German Institute of Human Nutrition, Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany. flohe@mail.dife.de
Roob
Johannes M
JM
Tiran
Beate
B
Wuga
Sandra
S
Ribalta
Josep
J
Rock
Edmond
E
Winklhofer-Roob
Brigitte M
BM
D000042:Absorption; D000328:Adult; D000368:Aged; D000375:Aging; D001317:Austria; D002839:Chromans / Q000652:urine; D003903:Deuterium; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011422:Propionates / Q000652:urine; D024505:Tocopherols / Q000378:metabolism* / Q000493:pharmacokinetics*; D014810:Vitamin E / Q000378:metabolism*; D024502:alpha-Tocopherol / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D024504:gamma-Tocopherol / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine
D002839:Chromans; D011422:Propionates; D014810:Vitamin E; C107690:2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman; C084852:2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman; D024504:gamma-Tocopherol; D003903:Deuterium; D024502:alpha-Tocopherol; D024505:Tocopherols