[Malondialdehyde and reduced glutathione increase in patients with chronic stable ischaemic cardiopathy].
OBJECTIVE
Cardiovascular diseases are associated with the ischemia/reperfusion phenomena and therefore to the oxidation/antioxidation balance. The aim of this study was to determine malondialdehyde, nitric oxide, glutathione, ascorbic and dehydroascorbic acid in patients with chronic ischemic heart disease.


METHODS
32 male patients, with chronic ischemic heart disease, between 40 and 60 years of age were studied. These individuals were divided in two groups: 16 with hypertension and 16 without hypertension. Both groups were compared with 31 healthy male subjects (control group).


RESULTS
Significant differences (p < 0.001) was observed in malondialdehyde between no-hypertension ischemic group: 5.3 (1.5) microM and the hypertension ischemic group: 4.8 (1.3) microM in contrast with the healthy group: 2.2 (0.5) microM. Hypertension ischemic group showed significant greater reduced glutation levels: 286.1 (31.4) microg/ml than control group 262.0 (38.8) microg/ml; p < 0.03 and no-hypertension ischemic group: 256.4 (41.5) microg/ml; p < 0.02. No significant difference in the rest of the parameters for all study groups.


CONCLUSIONS
Oxidation/antioxidation balance during chronic ischemic heart disease can be considered as a good metabolic ischemia indicator, that used in the monitoring and therapeutic evaluation could detect molecular changes that anticipate installation of tissue damage.
Cabrera de Bravo
Mayela Carolina
MC
Centro de Investigaciones Endocrino-metabólicas Dr. Félix Gómez, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
Bermúdez Pirela
Valmore José
VJ
Bermúdez Arias
Fernando
F
Cano Ponce
Clímaco
C
Mengual Moreno
Edgardo José
EJ
Leal González
Elliuz Marina
EM
D000328:Adult; D002908:Chronic Disease; D004562:Electrocardiography; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000378:metabolism*
D008315:Malondialdehyde; D005978:Glutathione