title: Increased frequency of sister chromatid exchanges in peripheral lymphocytes of alcoholics and cigarette smokers.
abstract: Sister chromatid exchange (SCE) is a sensitive indicator of genotoxicity. In this study we investigated the effects of alcohol consumption and cigarette smoking on the frequency of SCE in cultures of peripheral lymphocytes. The rate was higher in alcoholics who smoked (10.89+/-2.46) and in smokers (positive controls) (7.64+/-1.01) than in healthy non-smokers (negative controls) (6.96+/-2.18). Statistical analysis suggested that the increases were related to alcohol consumption and cigarette smoking (p<0.05).
authors.affiliation: Department of Medical Genetics, Gazi University School of Medicine, Besevler, 06500 Ankara, Turkey. karaoguz@gazi.edu.tr
authors.forename: Meral Yirmibeş
authors.initials: MY
authors.lastname: Karaoğuz
authors.forename: Behçet
authors.initials: B
authors.lastname: Coşar
authors.forename: Zehra
authors.initials: Z
authors.lastname: Arikan
authors.forename: Feride
authors.initials: F
authors.lastname: Başaran
authors.forename: Adnan
authors.initials: A
authors.lastname: Menevşe
authors.forename: Sevda
authors.initials: S
authors.lastname: Menevşe
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000235:genetics*