Reduction of blood pressure with calcium and potassium supplementation in children with salt sensitivity: a 2-year double-blinded placebo-controlled trial.
An investigation of the reductive effect of blood pressure and increment of urinary sodium excretion with calcium and potassium supplementation in children with sodium sensitivity is conducted. In total of 261 school children who had completed a 2-year double-blinded, placebo-controlled trial with calcium and potassium supplementation salt sensitivity, with a salt volume expansion and contraction protocol, was determined. The results showed that in children with salt sensitivity, the increase in blood pressure in the supplementary group was lower by 4.3/4.8 mmHg than that in the placebo group (P<0.05), while no significant change was found between the supplementary group and placebo group in children with nonsalt sensitivity. With calcium and potassium supplementation, the night urinary sodium excretion in children with salt sensitivity was significantly increased (P<0.01), and it is negatively correlated with the increase in blood pressure. It was suggested that a moderate increase of calcium and potassium intake in children with salt sensitivity, through interaction with sodium, can promote urinary sodium excretion and may play contribute to the prevention of hypertension.
Mu
J J
JJ
Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College, Xian Jiaotong University, Xian, PR China. mujjun01@sohu.com
Liu
Z Q
ZQ
Liu
W M
WM
Liang
Y M
YM
Yang
D Y
DY
Zhu
D J
DJ
Wang
Z X
ZX
D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000627:therapeutic use*; D002648:Child; D002940:Circadian Rhythm; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000517:prevention & control*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000627:therapeutic use*; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride; D011188:Potassium; D002118:Calcium