Spotted fever group and typhus group rickettsioses in humans, South Korea.
The presence of the nucleic acid of the spotted fever group (SPG) and typhus group (TG) rickettsiae was investigated in 200 serum specimens seropositive for SFG rickettsiae by multiplex-nested polymerase chain reaction with primers derived from the rickettsial outer membrane protein B gene. The DNA of SFG, TG, or both rickettsiae was amplified in the 24 serum specimens, and sequence analysis showed Rickettsia conorii, R. japonica, and R. felis in the specimens. R. conorii and R. typhi were found in 7 serum specimens, which indicated the possibility of dual infection in these patients. These findings suggest that several kinds of rickettsial diseases, including boutonneuse fever, rickettsialpox, R. felis infection, and Japanese spotted fever, as well as scrub typhus and murine typhus, are occurring in Korea.
Choi
Yeon-Joo
YJ
Konkuk University, Choongbuk, Republic of Korea.
Jang
Won-Jong
WJ
Konkuk University, Choongbuk, Republic of Korea.
Kim
Jong-Hyun
JH
Konkuk University, Choongbuk, Republic of Korea.
Ryu
Ji-Sun
JS
Konkuk University, Choongbuk, Republic of Korea.
Lee
Seung-Hyun
SH
Konkuk University, Choongbuk, Republic of Korea.
Park
Kyung-Hee
KH
Konkuk University, Choongbuk, Republic of Korea.
Paik
Hyung-Suk
HS
Pusan National University, Pusan, Republic of Korea.
Koh
Young-Sang
YS
Cheju National University College of Medicine, Jeju, Republic of Korea.
Choi
Myung-Sik
MS
Seoul National University College of Medicine and Institute of Endemic Disease, Seoul, Republic of Korea.
Kim
Ik-Sang
IS
Seoul National University College of Medicine and Institute of Endemic Disease, Seoul, Republic of Korea.
D000942:Antigens, Bacterial / Q000737:chemistry / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D003001:Cloning, Molecular; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012281:Rickettsia / Q000235:genetics / Q000302:isolation & purification*; D012282:Rickettsia Infections / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology; D016415:Sequence Alignment
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C073150:rOmp B protein, Rickettsia