title: [Biomarkers as prognostic factors in pulmonary arterial hypertension. Rationale and study design].
abstract: BACKGROUND
  Pulmonary arterial hypertension (PAH) is a serious disease. Its prognostic is based on the functional status quantified by the NYHA class and the 6-min walking test, and the hemodynamic data. The algorithms of treatment are solely based on the hemodynamic data and the functional status. The main objective is to test whether basal concentrations of isoprostanes, Big endotheline 1, ADMA, high sensitivity CRP, NT-Pro-BNP and cardiac troponin T are a 3-year prognostic factor in PAH using a combined criterion: death from any cause and pulmonary or cardiopulmonary transplantation.
  
  
  METHODS
  This is a multicenter, prospective, prognostic, single blinded study (plasma and urinary samples being blinded). The study started in november 2003, running for 2 years, with a 3 year follow-up for each patient. The main inclusion criterion is PAH. The data analysis will use a multivariable Cox model, taking into account the functional and hemodynamic parameters.
  
  
  RESULTS
  This study will determine whether any of the biomarkers tested provides additional prognostic information in PAH in addition to the functional and hemodynamic parameters.
authors.affiliation: Centre d'Investigation, Clinique Inserm 003, Grenoble, France. JLCracowski@chu-grenoble.fr
authors.forename: J L
authors.initials: JL
authors.lastname: Cracowski
authors.forename: A
authors.initials: A
authors.lastname: Yaici
authors.forename: O
authors.initials: O
authors.lastname: Sitbon
authors.forename: M
authors.initials: M
authors.lastname: Reynaud-Gaubert
authors.forename: J C
authors.initials: JC
authors.lastname: Renversez
authors.forename: C
authors.initials: C
authors.lastname: Pison
authors.forename: P
authors.initials: P
authors.lastname: Faure
authors.forename: C
authors.initials: C
authors.lastname: Cracowski
authors.forename: N
authors.initials: N
authors.lastname: Chouri
authors.forename: A
authors.initials: A
authors.lastname: Chaouat
authors.forename: F
authors.initials: F
authors.lastname: Chabot
authors.forename: E
authors.initials: E
authors.lastname: Schwedhelm
authors.forename: R
authors.initials: R
authors.lastname: Maas
authors.forename: B
authors.initials: B
authors.lastname: Degano
authors.forename: J F
authors.initials: JF
authors.lastname: Mornex
authors.forename: M
authors.initials: M
authors.lastname: Humbert
mesh_terms: D015415:Biomarkers / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D016037:Single-Blind Method
chemical_list: D015415:Biomarkers