[The preparation of sintered bovine cancellous bone and a study of its mechanical and chemical behavior and biocompatibility].
This article is devoted to a method for preparing a new bone plant material--sintered bovine cancellous bone with beta-TCP type, and to study the mechanical and chemical behavior of the material such as the diameter of the pores, the compress and bend intensity, and the component, and the rate of the porosity. The biocompatibility of the bone was assessed by hemolysis test, micronucleus test, systemic acute toxicity test, local irritation reaction, pyrogen test, and the test of planting in the body. The study indicate that the sintered bovine cancellous bone with beta-TCP type had certain intension, appropriate aperture, connective pore and credible biosecurity, it could be used clinically as bone graft material.
Zheng
Qixin
Q
Department of Orthopaedics, Xiehe Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430022, China.
Liu
Sunan
S
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry*; D001842:Bone and Bones / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002417:Cattle; D005260:Female; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing; D051379:Mice; D016062:Porosity; D011817:Rabbits; D011897:Random Allocation
D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate