title: Iodine overload and severe hypothyroidism in a premature neonate.
abstract: Use of iodinated skin disinfectants in the perinatal period can result in significant iodine overload of the neonate and transient hypothyroidism. The authors report a case of unusually severe hypothyroidism requiring L-thyroxine (L-T4) replacement therapy in a premature neonate after prolonged use of iodinated skin disinfectants for a complex skin lesion. Neonatal iodine overload should be minimized, and in cases with significant iodine exposure, thyroid-stimulating hormone should be monitored, especially in preterm neonates who are exquisitely sensitive to the antithyroid effects of iodine excess.
authors.affiliation: Division of Neonatology, Department of Pediatrics, British Columbia Children's Hospital and University of British Columbia, Vancouver BC V6H 3V4, Canada.
authors.forename: Minesh
authors.initials: M
authors.lastname: Khashu
authors.forename: Philippe
authors.initials: P
authors.lastname: Chessex
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Chanoine
mesh_terms: D000891:Anti-Infective Agents, Local / Q000009:adverse effects*; D003879:Dermatologic Agents / Q000009:adverse effects*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000188:drug therapy; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011206:Povidone-Iodine / Q000009:adverse effects*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D000891:Anti-Infective Agents, Local; D003879:Dermatologic Agents; D011206:Povidone-Iodine; D013972:Thyrotropin; D013974:Thyroxine