[Molecular basis of pituitary adenomas with emphasis on somatotropinomas].
This review describes the molecular basis of pituitary adenomas with emphasis on GH-secreting tumors (somatotropinomas). The roles of tumor suppressor genes (such as RB1 and MEN-1) and oncogenes (such as gsp and PTTG) in tumor initiation and promotion are discussed. The characterization of these molecular markers may contribute to the understanding of tumor behavior, helping in the therapeutical management. However, despite recent advances, the sequence of genetic abnormalities participating in the pathogenesis of these adenomas is not completely known.
Donangelo
Ines
I
Serviço de Endocrinologia, Hospital Universitário Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ.
Gadelha
Mônica
M
D000236:Adenoma / Q000235:genetics* / Q000378:metabolism*; D016147:Genes, Tumor Suppressor / Q000502:physiology; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D009857:Oncogenes / Q000235:genetics; D010911:Pituitary Neoplasms / Q000235:genetics* / Q000378:metabolism*
D013006:Growth Hormone