Comparison of cerebral blood flow between perfusion computed tomography and xenon-enhanced computed tomography for normal subjects: territorial analysis.
OBJECTIVE
The purpose of this study was to clarify the difference between cerebral blood flow (CBF) by perfusion computed tomography (CT) and that by xenon-enhanced CT (Xe-CT) through simultaneous measurement.


METHODS
Xenon-enhanced CT and perfusion CT were continually performed on 7 normal subjects. Ratios of CBF by perfusion CT (P-CBF) to CBF by Xe-CT (Xe-CBF) were measured for 5 arterial territories; 3 were territories of 3 major arteries (the anterior [ACA], middle [MCA], and posterior [PCA] cerebral arteries), and the other 2 were areas of the thalamus and putamen.


RESULTS
The ratios were 1.30 +/- 0.10, 1.26 +/- 0.15, 1.61 +/- 0.15, 0.801 +/- 0.087, and 0.798 +/- 0.080 for the ACA, MCA, PCA, thalamus, and putamen, respectively. Although a good correlation was observed between P-CBF and Xe-CBF for each territory, the ratios were significantly different (P < 0.0001) between 3 territory groups (group 1: ACA and MCA, group 2: PCA, and group 3: thalamus and putamen).


CONCLUSIONS
The difference in the ratio of P-CBF to Xe-CBF between the 3 territory groups was considered to result principally from the features of P-CBF. To evaluate P-CBF properly, its territorial characteristics should be taken into account.
Sase
Shigeru
S
Anzai Medical Company, Ltd., Tokyo, Japan. sase@anzai-med.co.jp
Honda
Mitsuru
M
Machida
Keiichi
K
Seiki
Yoshikatsu
Y
D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000098:blood supply; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D003287:Contrast Media; D003392:Cranial Sinuses / Q000000981:diagnostic imaging; D005260:Female; D006261:Headache / Q000000981:diagnostic imaging; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011699:Putamen / Q000098:blood supply; D012039:Regional Blood Flow / Q000502:physiology; D012680:Sensitivity and Specificity; D013788:Thalamus / Q000098:blood supply; D014057:Tomography, X-Ray Computed; D014717:Vertigo / Q000000981:diagnostic imaging; D014978:Xenon
D003287:Contrast Media; D014978:Xenon