title: 7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoliata.
abstract: From the acetone extract of the roots of Derris trifoliata an isoflavonoid derivative, named 7a-O-methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isoflavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known rotenoids, rotenone, deguelin and alpha-toxicarol, were identified. The structures were determined on the basis of spectroscopic evidence. Rotenone and deguelin were identified as the larvicidal principles of the acetone extract of the roots of Derris trifoliata.
authors.affiliation: Department of Chemistry, University of Nairobi, P.O. Box 30197, Nairobi, Kenya. ayenesew@uonbi.ac.ke
authors.forename: Abiy
authors.initials: A
authors.lastname: Yenesew
authors.forename: Eluid K
authors.initials: EK
authors.lastname: Mushibe
authors.forename: Martha
authors.initials: M
authors.lastname: Induli
authors.forename: Solomon
authors.initials: S
authors.lastname: Derese
authors.forename: J O
authors.initials: JO
authors.lastname: Midiwo
authors.forename: Jacques M
authors.initials: JM
authors.lastname: Kabaru
authors.forename: Matthias
authors.initials: M
authors.lastname: Heydenreich
authors.forename: Andreas
authors.initials: A
authors.lastname: Koch
authors.forename: Martin G
authors.initials: MG
authors.lastname: Peter
mesh_terms: D000818:Animals; D003465:Culex; D029866:Derris / Q000737:chemistry*; D007306:Insecticides / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva; D008958:Models, Molecular; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D012402:Rotenone / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C501191:7a-O-methyldeguelol; D007306:Insecticides; C501190:alpha-toxicarol; D012402:Rotenone; C107676:deguelin