title: [Researches on the establishment of chronic nephropathy models and the effect of TCM on these models].
abstract: Following contents were reviewed in this article: More and more experimental studies related with chronic uratic nephropathy were carried out in recent years. In most of these studies, the animal models were established mainly from viewpoints of gene recombination, urinary uric acid inhibition and blood uric acid production promoting. TCM showed good effects in lowering blood uric acid, regulating levels of cytokines and postponing interstitial fibrosis. However, further studies on Chinese herbs and their extracts is necessary.
authors.affiliation: Department of Renal Diseases, Longhua Hospital, Shanghai TCM University, Shanghai 200032. gaozhiqing@sina.com
authors.forename: Zhi-qing
authors.initials: ZQ
authors.lastname: Gao
authors.forename: Yue-yi
authors.initials: YY
authors.lastname: Deng
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Chen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D033461:Hyperuricemia / Q000097:blood; D007674:Kidney Diseases / Q000209:etiology; D051379:Mice; D008517:Phytotherapy; D011687:Purines / Q000378:metabolism; D051381:Rats; D014527:Uric Acid / Q000097:blood
chemical_list: D004365:Drugs, Chinese Herbal; D011687:Purines; D014527:Uric Acid; C030985:purine