title: Expression of Stat3 in germ cells of developing and adult mouse ovaries and testes.
abstract: The Signal transducers and activators of transcription (Stat) family of proteins plays diverse roles during differentiation in many tissues. Stat3 is an essential mammalian gene, critical during embryonic development. In mammals, Stat3 is differentially distributed in the cytoplasm of mature oocytes and in preimplantation embryos suggesting that Stat3 may be involved in determination of polarity. Here, we report that Stat3 protein is expressed in the cytoplasm of oocytes from primordial, primary and secondary follicles in the adult ovary and in developing acrosomes of round spermatids in the adult testis. Stat3 is also expressed in gonocytes, prospermatogonia, oogonia and oocytes of embryonic and neonatal gonads.
authors.affiliation: Department of Biology, Syracuse University, 130 College Place, Syracuse, NY 13244, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Murphy
authors.forename: Luis
authors.initials: L
authors.lastname: Carvajal
authors.forename: Leo
authors.initials: L
authors.lastname: Medico
authors.forename: Melissa
authors.initials: M
authors.lastname: Pepling
mesh_terms: D000818:Animals; D036703:Blastula / Q000502:physiology; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics*; D010064:Embryo Implantation; D047108:Embryonic Development; D005260:Female; D018507:Gene Expression Regulation, Developmental; D007150:Immunohistochemistry; D008297:Male; D008322:Mammals; D051379:Mice; D009865:Oocytes; D010053:Ovary / Q000196:embryology / Q000502:physiology*; D010063:Ovum / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050796:STAT3 Transcription Factor; D013087:Spermatids / Q000502:physiology; D013094:Spermatozoa / Q000502:physiology*; D013737:Testis / Q000196:embryology / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics*
chemical_list: D017931:DNA Primers; D004268:DNA-Binding Proteins; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D015534:Trans-Activators