title: [Relationship between heat stress protein 70 gene polymorphisms and the risk of acute mountain sickness].
abstract: OBJECTIVE
  To investigate the relationship between heat stress proteins 70 (HSPs70) gene polymorphism and the risk of acute mountain sickness.
  
  
  METHODS
  Fifty-six soldiers with acute mountain sickness and 173 soldiers without that were chosen as cases and controls. HSP70-1, HSP70-2 genotypes were analyzed by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
  
  
  RESULTS
  The HSP70-1 polymorphism was similar in two groups. The genotype frequency of HSP70-2 B/B in acute mountain sickness group (23.2%) was significantly higher than that in the control (6.9%, P < 0.05, OR = 4.02).
  
  
  CONCLUSIONS
  There is a significantly increased association of HSP70-2 B/B genotype with the risk of acute mountain sickness. Individuals with HSP70-2 B/B genotype may have weaker adaptive ability than those without this genotype under altitude stress. The results contribute to provide scientific bases for finding these individuals in specified occupational people, ensuring their health and enhancing work efficiency.
authors.affiliation: Clinical Laboratory of the Hospital of the General Armed Police Force of Sichuan, Chengdu 610041, China.
authors.forename: Fang-Ze
authors.initials: FZ
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Zhou
authors.forename: Chang-Zheng
authors.initials: CZ
authors.lastname: Jiang
authors.forename: Su-Yong
authors.initials: SY
authors.lastname: Sun
authors.forename: Mei-An
authors.initials: MA
authors.lastname: He
authors.forename: Shu-Yu
authors.initials: SY
authors.lastname: Zhang
authors.forename: Rong
authors.initials: R
authors.lastname: Liao
authors.forename: Hua-Song
authors.initials: HS
authors.lastname: Zeng
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Wu
authors.forename: Tang-Chun
authors.initials: TC
authors.lastname: Wu
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D018840:HSP70 Heat-Shock Proteins