title: Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women.
abstract: OBJECTIVE
  To investigate whether nutritional intervention with a proprietary formulation and other micronutrients may favourably alter skin roughness and elasticity.
  
  
  METHODS
  Sixty-two women aged 45-73 years participated in a double-blind, placebo-controlled trial testing the efficacy of a proprietary oral supplement for skin nutrition (Evelle), for improvement of skin elasticity and roughness. The active ingredients were vitamins C and E, carotenoids, selenium, zinc, amino acids and glycosaminoglycans, blueberry extract and Pycnogenol.
  
  
  RESULTS
  Skin elasticity, measured using an optical cutometer, was found to be statistically significantly increased by 9% after 6 weeks of treatment compared with placebo (p=0.0351). Skin roughness, as evaluated by three-dimensional microtopography imaging, was found to be statistically significantly lowered by 6% compared with the control group after 12 weeks treatment (p=0.0157).
  
  
  CONCLUSIONS
  Evelle can potentially improve visible signs of cutaneous ageing.
authors.affiliation: Skin Investigation and Technology, 20354 Hamburg, Germany. d.segger@t-online.de
authors.forename: D
authors.initials: D
authors.lastname: Segger
authors.forename: F
authors.initials: F
authors.lastname: Schönlau
mesh_terms: D000368:Aged; D019587:Dietary Supplements; D004311:Double-Blind Method; D004548:Elasticity; D005419:Flavonoids / Q000008:administration & dosage*; D006801:Humans; D018977:Micronutrients / Q000008:administration & dosage*; D008875:Middle Aged; D010936:Plant Extracts; D015595:Skin Aging / Q000187:drug effects*; D012879:Skin Physiological Phenomena / Q000187:drug effects; D013607:Tablets
chemical_list: D005419:Flavonoids; D018977:Micronutrients; D010936:Plant Extracts; D013607:Tablets; C024070:pycnogenols