title: [Assessment of efficacy of migraine attack treatment with lysine acetylsalicylate and metoclopramide].
abstract: Migraine is a common medical condition affecting nearly 10% of population in Poland. The aim of the study was to evaluate the efficacy, tolerability and safety of migraine abortive treatment with the combination of lysine acetylsalicylate and metoclopramide (1620 mg LAS + 10 mg MTC--Migpriv). 1620 patients with migraine, meeting International Headache Society (IHS) criteria were included in the study. The aim of the study was also determination of the number of patients having headache relief and no nausea or vomiting two hours after the drug intake. In most patients the migraine symptoms disappeared after a single dose administration. Reported adverse events were rare and short lasting. The study showed that metoclopramide was well tolerated and effective at relieving migraine attack symptoms.
authors.affiliation: Wojskowy Instytut Medyczny, Klinika Neurologii w Warszawie.
authors.forename: Adam
authors.initials: A
authors.lastname: Stepień
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kozubski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008297:Male; D008787:Metoclopramide; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018492:Dopamine Antagonists; D008239:Lysine; D008787:Metoclopramide; D001241:Aspirin; C010395:acetylsalicylic acid lysinate