Polytopic proteins: preventing aggregation in the membrane.
It has been proposed that the aggregation of nascent transmembrane segments of polytopic proteins is prevented by chaperones present in the endoplasmic reticulum membrane; now the first experimental support for this proposal has been reported.
Lord
J Michael
JM
Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK.
High
Stephen
S
D002352:Carrier Proteins / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D008565:Membrane Proteins / Q000096:biosynthesis / Q000378:metabolism*; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D017510:Protein Folding; D017434:Protein Structure, Tertiary / Q000502:physiology; D000069816:SEC Translocation Channels
D002352:Carrier Proteins; D008565:Membrane Proteins; D018832:Molecular Chaperones; D000069816:SEC Translocation Channels