Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities.
A diprenylated indole, (E)-3-(3-hydroxymethyl-2-butenyl)-7-(3-methyl-2-butenyl)-1H-indole (1), and six known carbazole alkaloids were isolated from the twigs and leaves of Glycosmis montana Pierre (Rutaceae). Their structures were determined on the basis of analysis of spectral evidence including 1D and 2D NMR and MS. The alkaloids (1-3) exhibited weak to moderate take in vitro inhibitory activity against HIV replication in C8166 cells, and they (as well as carbalexine A and B) had cytotoxic activity against the human leukaemia cell line CCRF-CEM.
Wang
Junsong
J
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongton, Kunming, Yunnan 650204, PR China.
Zheng
Yongtang
Y
Efferth
Thomas
T
Wang
Ruirui
R
Shen
Yuemao
Y
Hao
Xiaojiang
X
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007938:Leukemia / Q000188:drug therapy; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*
D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D002227:Carbazoles; D007211:Indoles