The Utah paradigm on animal models of skeletal disorders: quo vadis?
Skeletal disorders that need effective studies in suitable animal models include "osteoporosis", arthroses and hard and soft tissue healing. For people doing or analyzing such studies this article provides a brief overview and some salient implications of the Utah paradigm of skeletal physiology. The article leaves discussing and resolving any disagreements and controversies about such things to other times, places and people.
Frost
H M
HM
Department of Orthopaedic Surgery, Southern Colorado Clinic, Pueblo, Colorado 81008-9000, USA. hmfrost@juno.com