title: Coexistence of brenner tumor and struma ovarii: case report.
abstract: BACKGROUND
  There has been controversy regarding the histogenesis of Brenner tumors. It is generally accepted that Brenner tumors are derived directly from ovarian surface epithelium, which undergoes metaplasia to form the typical urothelial-like components, whereas some investigators assume that Brenner tumors arise from immature germ cells.
  
  
  METHODS
  We describe a well-documented case of the coexistence of struma ovarii regarded as a form of teratoma and Brenner tumor in the same ovary. Immunohistologically, not only columnar cells of thyroid follicles, but also transitional cells of Brenner nests were positive for thyroglobulin.
  
  
  CONCLUSIONS
  In the present case, Brenner tumors and thyroid elements coexisted and were positive for thyroglobulin. While there is strong evidence that pure Brenner tumors originate mostly from the ovarian surface, at least Brenner tumors associated with teratomatous elements may have a germ cell origin.
authors.affiliation: Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: C
authors.initials: C
authors.lastname: Ohbayashi
authors.forename: S
authors.initials: S
authors.lastname: Kitazawa
authors.forename: N
authors.initials: N
authors.lastname: Ohara
authors.forename: T
authors.initials: T
authors.lastname: Maruo
mesh_terms: D000328:Adult; D001948:Brenner Tumor / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013330:Struma Ovarii / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014592:Uterine Hemorrhage / Q000209:etiology