title: Noise-induced cooperative behavior in a multicell system.
abstract: BACKGROUND
  All cell components exhibit intracellular noise on account of random births and deaths of individual molecules, and extracellular noise because of environment perturbations. Gene regulation in particular, is an inherently noisy process with transcriptional control, alternative splicing, translation, diffusion and chemical modification reactions, all of which involve stochastic fluctuations. Such stochastic noises may not only affect the dynamics of the entire system but may also be exploited by living organisms to actively facilitate certain functions, such as cooperative behavior and communication.
  
  
  RESULTS
  We have provided a general model and an analytic tool to examine the cooperative behavior of a multicell system with both intracellular and extracellular stochastic fluctuations. A multicell system with a synthetic gene network is adopted to demonstrate the effects of noises and coupling on collective dynamics. These results establish not only a theoretical foundation but also a quantitative basis for understanding essential roles of noises on cooperative dynamics, such as synchronization and communication among cells.
authors.affiliation: Department of Electrical Engineering and Electronics, Osaka Sangyo University, Daito, Osaka 574-8530, Japan. chen@elec.osaka-sandai.ac.jp
authors.forename: Luonan
authors.initials: L
authors.lastname: Chen
authors.forename: Ruiqi
authors.initials: R
authors.lastname: Wang
authors.forename: Tianshou
authors.initials: T
authors.lastname: Zhou
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Aihara
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000502:physiology*; D008954:Models, Biological; D015233:Models, Statistical; D015398:Signal Transduction / Q000502:physiology*; D013269:Stochastic Processes