Role of the intracellular receptor domain of gp130 (exon 17) in human inflammatory bowel disease.
OBJECTIVE
To study the role of the intracellular receptor domain of gp130 in human inflammatory bowel disease (IBD).


METHODS
We amplified and sequenced the complete exon 17 of the human gp130 gene in 146 patients with IBD. According to clinical and histopathological signs, the 146 patients with IBD were classified as having Crohn's disease (n = 73) or ulcerative colitis (n = 63), or as indeterminate status (n = 10).


RESULTS
No mutations in exon 17 of the gp130 gene could be detected in any of the 146 patients with IBD examined.


CONCLUSIONS
There is no evidence that mutations in exon 17 of the gp130 gene are involved in the pathogenesis of human IBD.
Auernhammer
Christoph-J
CJ
Department of Internal Medicine II, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistr 15, D-81377 Munich, Germany. christoph.auernhammer@med.uni-muenchen.de
Zitzmann
Kathrin
K
Schnitzler
Fabian
F
Seiderer
Julia
J
Lohse
Peter
P
Vlotides
George
G
Engelhardt
Dieter
D
Sackmann
Michael
M
Goke
Burkhard
B
Ochsenkuhn
Thomas
T
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000737:chemistry / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D050822:Cytokine Receptor gp130; D005091:Exons; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics*; D008875:Middle Aged; D017434:Protein Structure, Tertiary
D015703:Antigens, CD; C494199:IL6ST protein, human; D008562:Membrane Glycoproteins; D050822:Cytokine Receptor gp130