title: [Study of the anti-icteric and hepatoprotective activity of Persea gratissima Gaertner (Lauraceae) seeds ].
abstract: The lyophilisat of Persea gratissima Gaertner almonds was administered in various quantities to eighty four rats divided in three groups of twenty eight. in the first group (negative reference group), each animal was forcefed with 5 ml of distilled water on a daily basis, in the second group (positive reference group), the rats were forcefed with 5 ml of distilled water per day, after they were intoxicated with 0,3 ml of carbon tetrachloride under cutaneous injection, in the third group (experimental animals), each animal after it was intoxicated by the same quantity of carbon tetrachloride, was forcefed on a daily basis with 14mg/100g PV of lyophilisat of avocado almonds diluted with 5 ml of distilled water. The results showed that the lyophilisat of avocado almonds have a anti-icteric activity which is reflected in the stimulation of the liver to conjugate and eliminate bilirubin, as well as hepatoprotective activity characterised by the normalisation of the aminotransferases enzymes (ASAT, ALAT) and the healing of hepatic lesions within 10 days.
authors.affiliation: Laboratoire de Physiologie et Thérapeutiques. Ecole Inter-Etats des Sciences et Médecine Vétérinaires de Dakar.
authors.forename: M
authors.initials: M
authors.lastname: Assane
authors.forename: P A
authors.initials: PA
authors.lastname: Diop
authors.forename: M
authors.initials: M
authors.lastname: Niang-Sylla
authors.forename: P
authors.initials: P
authors.lastname: Lopez-Sall
authors.forename: P M
authors.initials: PM
authors.lastname: Gueye
authors.forename: A
authors.initials: A
authors.lastname: Charlevna
mesh_terms: D000818:Animals; D007565:Jaundice / Q000188:drug therapy*; D008107:Liver Diseases / Q000517:prevention & control*; D051379:Mice; D027421:Persea; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds
chemical_list: D010936:Plant Extracts