title: Catastrophic antiphospholipid syndrome: atypical presentation in the setting of chronic graft versus host disease: case report and review of the literature.
abstract: A 44-year-old female developed a catastrophic thrombotic syndrome following allogeneic stem cell transplantation for acute lymphoblastic leukemia. In the context of chronic graft versus host disease, she developed a lethal multi-system thrombotic state as evidenced by stroke, renal failure and cardiac thrombi in association with elevated anticardiolipin antibody. The case is discussed in the framework of the existing literature and derives clinical practice recommendations for this rare but clinically devastating entity.
authors.affiliation: Department of Hematology, Greenebaum Cancer Center, University of Maryland, Baltimore 21201, USA.
authors.forename: Karl M
authors.initials: KM
authors.lastname: Kasamon
authors.forename: Cynthia I
authors.initials: CI
authors.lastname: Drachenberg
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Rapoport
authors.forename: Ashraf
authors.initials: A
authors.lastname: Badros
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000209:etiology*; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000628:therapy; D013927:Thrombosis / Q000209:etiology
chemical_list: D017153:Antibodies, Anticardiolipin