Mismatch between gallium-67 uptake and CT findings in a case of pulmonary alveolar proteinosis.
Gallium-67 citrate (67Ga) scintigraphy has been used as an indicator of activity of diffuse interstitial lung diseases. However, little has been mentioned in pulmonary alveolar proteinosis (PAP). Here we present a 53-year-old man with PAP showing patchy 67Ga uptake by single photon emission computed tomography (SPECT). Interestingly, the strong 67Ga uptake was observed in areas where ground-glass opacities were faint on chest CT. The uptake persisted after whole-lung lavage while the ground-glass opacity improved markedly. Although the precise mechanism of 67Ga uptake remains unclear, 67Ga SPECT findings may reflect the different pathological condition of PAP than that shown by CT.
Hashimoto
Michiko
M
Department of Respiratory Medicine, University of Tsukuba, Japan.
Ishii
Yukio
Y
Takeda
Tohoru
T
Wu
Jin
J
Thet-Thet-Lwin
Sekizawa
Kiyohisa
K
D002951:Citrates / Q000493:pharmacokinetics*; D005708:Gallium / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011649:Pulmonary Alveolar Proteinosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
D002951:Citrates; D019275:Radiopharmaceuticals; D005708:Gallium; C103850:gallium citrate