title: Early developmental changes in IGF-I, IGF-II, IGF binding protein-1, and IGF binding protein-3 concentration in the cerebrospinal fluid of children.
abstract: IGF-I and IGF-II are ubiquitously expressed growth factors that have profound effects on the growth and differentiation of many cell types and tissues, including cells of the CNS. In biologic fluids, most IGFs are bound to one of six IGF binding proteins (IGFBPs 1-6). Increasing evidence strongly supports a role for IGF-I in CNS development, as it promotes neuronal proliferation and survival. However, little is known about IGF-I and its homolog IGF-II and their carrier proteins, IGFBPs, during the neonatal period in which brain size increases dramatically, myelination takes place, and neurons show limited capacity to proliferate. Herein, we have determined the concentrations of IGF-I, IGF-II, IGFBP-1, and IGFBP-3 in cerebral spinal fluid (CSF) samples that were collected from children who were 1 wk to 18 y of age. The concentrations of IGF-I, IGFBP-1, and IGFBP-3 in CSF from children <6 mo of age were significantly higher than in older children, whereas IGF-II was higher in the older group. This is in contrast to what is observed in the peripheral circulation, where IGF-I and IGFBP-3 are low at birth and rise rapidly during the first year, reaching peak levels during puberty. Higher concentrations of IGF-I, IGFBP-1, and IGFBP-3 in the CSF of very young children suggest that these proteins might participate in the active processes of myelination and synapse formation in the developing nervous system. We propose that IGF-I and certain IGFBPs are likely necessary for normal CNS development during critical stages of neonatal brain growth and development.
authors.affiliation: Arkansas Children's Hospital Research Institute, and Department of Pediatrics, University of Arkansas for Medical Sciences, 1120 Marshall Street, Little Rock, AR 72202, USA. bunnrobertc@uams.edu
authors.forename: R Clay
authors.initials: RC
authors.lastname: Bunn
authors.forename: William D
authors.initials: WD
authors.lastname: King
authors.forename: Margaret K
authors.initials: MK
authors.lastname: Winkler
authors.forename: John L
authors.initials: JL
authors.lastname: Fowlkes
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002624:Chemistry, Clinical / Q000379:methods; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000134:cerebrospinal fluid*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000134:cerebrospinal fluid*; D007334:Insulin-Like Growth Factor I / Q000134:cerebrospinal fluid*; D007335:Insulin-Like Growth Factor II / Q000134:cerebrospinal fluid*; D008297:Male; D009420:Nervous System / Q000254:growth & development; D009474:Neurons / Q000378:metabolism; D012737:Sex Factors
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II