The transcriptional signature of vitamin E.
To investigate the ability of RRR-alpha-tocopherol to regulate gene expression, we interrogated RNA samples from treated cultured cells with Affymetrix oligonucleutodie arrays. We find that vitamin E potently regulates the expression of ca. 230 genes, functioning in metabolism, cell-cycle progression, and transcriptional regulation.
Johnson
Amy
A
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
Manor
Danny
D
D002453:Cell Cycle / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D008660:Metabolism / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D014158:Transcription, Genetic / Q000187:drug effects; D024502:alpha-Tocopherol / Q000494:pharmacology*
D024502:alpha-Tocopherol