A/J mouse as a model for lung tumorigenesis caused by tobacco smoke: strengths and weaknesses.
Strain A/J mice have successfully been used to develop an animal model for tobacco smoke carcinogenesis. In 18 individual studies, reported by 4 different laboratories, a significant increase in lung tumor multiplicities following exposure from 50 to 170mg/m3 of total suspended tobacco smoke particulates was found in 15 studies (83 %) and a significant increase in lung tumor incidence in 10 studies (56%). However, tumor multiplicities are comparatively low (from an average of 1.1 to 2.8 tumors per lung). From a toxicological standpoint, this indicates that cigarette smoke is a weak animal carcinogen. Although the assay allowed one to detect substantial chemopreventive activity of a mixture of myo-inositol and dexamethasone, it was less successful in showing efficacy for several other agents.
Witschi
Hanspeter
H
Center for Health and Environment, University of California, Davis, CA 95616, USA. hrwitschi@ucdavis.edu
D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D000818:Animals; D002273:Carcinogens / Q000009:adverse effects*; D018890:Chemoprevention; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D019570:Inhalation Exposure; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D051379:Mice; D008805:Mice, Inbred A; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
D002273:Carcinogens; D014028:Tobacco Smoke Pollution