[Effect of the corticoliberin fragment CRF(4-6) on blood pressure and heart rate in rats].
The effects of tripeptide corticoliberin fragment CRF(4-6) (Pro-Pro-Ile) on blood pressure and heart rate of rats were investigated. Intracerebroventricularly injected CRF(4-6) (1.5-15.0 nmol/head) increases the mean arterial pressure and heart rate in conscious and anaesthetized animals in a dose-dependent manner. Corticotropin releasing factor antagonist: alpha-helical CRF(9-41) (6.5 nmol) completely abolished the influence of tripeptide CRF(4-6) (1.5 nmol) on blood pressure and heart rate in anaesthetized rats. This result indicates that corticoliberin receptors are involved in cardiovascular effects of CRF(4-6).
Makarenko
E Iu
EIu
Andreeva
L A
LA
Borovik
A S
AS
Mart'ianov
A A
AA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors
D010446:Peptide Fragments; D018019:Receptors, Corticotropin-Releasing Hormone; C488808:prolyl-prolylisoleucine; D003346:Corticotropin-Releasing Hormone; C045089:corticotropin releasing hormone (9-41)