Discrimination of normal and malignant gastric tissues with FTIR spectroscopy and principal component analysis.
In this paper, the identification of normal and malignant gastric tissues, including 11 cases of cancerous tissues and 10 cases of normal tissues, was investigated using mid-IR spectroscopy and principal componentanalysis (PCA). The results indicated that the difference between cancerous and normal tissues was found in the first principal component. The IR detection and PCA results are in agreement with the biopsy results. The combination of these two methods might provide a new opportunity for clinical application.
Griffiths
Peter R
PR
Department of Chemistry, College of Letters and Sciences, University of Idaho, ID 83844, USA.
Yang
Hu-sheng
HS
Li
Qing-bo
QB
Ling
Xiao-feng
XF
Wang
Jian-sheng
JS
Yang
Li-min
LM
Xu
Yi-zhuang
YZ
Weng
Shi-fu
SF
Wu
Jin-guang
JG
D000465:Algorithms; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005260:Female; D006801:Humans; D009363:Neoplasm Proteins; D025341:Principal Component Analysis / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016707:Tissue Fixation
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins