[CD1 pathway and NK T cell activation to glycolipid antigens from Mycobacterium tuberculosis].
The aim of this review is to analyze the current state of our knowledge about cell surface molecules involved in glycolipid antigen presentation, named CD1 family. These proteins constitute a third class of antigen-presenting molecules. CD1 molecules develop diverse important immune functions in host defenses against microbial infections. In recent years these proteins have been involved in the generation of cell-mediated immune response against Mycobacterium tuberculosis. Here, we analyze relevant roles of CD1 proteins and glycolipid antigen-specific T cells.
Sada-Ovalle
Isabel
I
Departamento de Bioquímica, Unidad de Investigación, Instituto Nacional de Enfermedades Respiratorias, Secretaria de Salud, México, DF. i_sadamx@yahoo.com.mx
Torre-Bouscoulet
Luis
L
Jiménez-Martínez
María del Carmen
Mdel C
Martínez-Cairo
Salvador
S
Zenteno
Edgar
E
Lascurain
Ricardo
R
D000942:Antigens, Bacterial / Q000276:immunology*; D018949:Antigens, CD1 / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006017:Glycolipids / Q000276:immunology*; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*
D000942:Antigens, Bacterial; D018949:Antigens, CD1; D006017:Glycolipids; C072681:Mycobacterium tuberculosis antigens