title: [Morphofunctional changes in gastrointestinal tract in patients with psoriasis accompanied by chronic opisthorchosis].
abstract: The paper covers clinical, morphological and functional aspects of gastrointestinal tract condition in patients with psoriasis accompanied by chronic opisthorchosis (CO). The authors examined 150 patients with psoriasis accompanied by CO, 100 patients having psoriasis without helminthiasis, 100 patients with CO and 30 healthy people. The gastric secretion was evaluated by means of the fractional test (both phases) with histamine stimulation; other diagnostic procedures included carbohydrate absorption evaluation (5-gram D-Xylose absorption test) and Kamer test of fat absorption. The morphological condition of the gastric and intestinal mucosa was investigated by means of light and electron microscopy. The study revealed gastric secretory dysfunction and malabsorption in small and large intestines in patients with psoriasis and CO, clarified the relation between the duration of psoriasis and opisthorchosis and gastric secretory dysfunction and determined dependence of small intestine malabsorption on such factors as stage, severity, degree of skin involvement and duration of psoriasis. The authors also established interrelation between the above malfunctions and gastric and intestinal structural abnormalities.
authors.forename: S A
authors.initials: SA
authors.lastname: Khardikova
authors.forename: E I
authors.initials: EI
authors.lastname: Beloborodova
authors.forename: P N
authors.initials: PN
authors.lastname: Pesterev
authors.forename: G I
authors.initials: GI
authors.lastname: Nepomniashchikh
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D041981:Gastrointestinal Tract / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000473:pathology; D008286:Malabsorption Syndromes / Q000209:etiology; D008297:Male; D009889:Opisthorchiasis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D011565:Psoriasis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors