title: Effect of triiodothyronine on gene transcription during cardiopulmonary bypass in infants with ventricular septal defect.
abstract: We tested the hypothesis that triiodothyronine (T3) supplementation alters gene transcription in the left ventricular myocardium of infants undergoing cardiopulmonary bypass for ventricular septal defect repair. To our knowledge, a novel heteronuclear assay demonstrated for the first time in human heart that rapid change in T3 levels altered the adenine nucleotide translocase-1 transcription rate during cardiopulmonary bypass.
authors.affiliation: Division of Endocrinology, Department of Medicine, North Shore University Hospital/New York University School of Medicine, Manhasset, New York, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Danzi
authors.forename: Irwin
authors.initials: I
authors.lastname: Klein
authors.forename: Michael A
authors.initials: MA
authors.lastname: Portman
mesh_terms: D033741:Adenine Nucleotide Translocator 1 / Q000235:genetics; D001707:Biopsy, Needle; D002315:Cardiopulmonary Bypass; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000235:genetics / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D009206:Myocardium / Q000473:pathology*; D016133:Polymerase Chain Reaction; D012332:RNA, Heterogeneous Nuclear / Q000235:genetics; D019831:Sodium-Calcium Exchanger / Q000235:genetics; D013771:Tetralogy of Fallot; D014158:Transcription, Genetic / Q000187:drug effects / Q000235:genetics*; D014284:Triiodothyronine / Q000008:administration & dosage / Q000502:physiology*; D024723:Ventricular Myosins / Q000235:genetics
chemical_list: D033741:Adenine Nucleotide Translocator 1; D012332:RNA, Heterogeneous Nuclear; D019831:Sodium-Calcium Exchanger; D014284:Triiodothyronine; D024723:Ventricular Myosins