title: Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae).
abstract: The butanolic fraction of dried leaves of Acacia pennata (Mimosaceae) was tested for analgesic and anti-inflammatory activities in animal models. It showed significant protective effects against chemical stimuli (acetic acid and formalin) in the mouse. It also produced a significant increase of the threshold of sensitivity to pressure-induced pain in the rats. The extract revealed an inhibitory effect in carrageenin-induced rat paw oedema in the late phase. The results suggested that a peripheral mechanism is involved in the analgesic, associated to anti-inflammatory effect (NSAIDs-like). Among the class of compounds characterized in this fraction, flavonoids may be mainly responsible for the pharmacological activities.
authors.affiliation: Laboratoire de Biologie des Organismes animaux, Faculté des Sciences, Université de Douala, BP 24157 Douala, Cameroun.
authors.forename: A B
authors.initials: AB
authors.lastname: Dongmo
authors.forename: T
authors.initials: T
authors.lastname: Nguelefack
authors.forename: M A
authors.initials: MA
authors.lastname: Lacaille-Dubois
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage / Q000009:adverse effects; D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000440:Butanols / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use; D002351:Carrageenan / Q000009:adverse effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D005557:Formaldehyde / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors; D006614:Hindlimb / Q000503:physiopathology; D008297:Male; D051379:Mice; D031298:Mimosa / Q000737:chemistry*; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011312:Pressure / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D014147:Tramadol / Q000494:pharmacology
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000440:Butanols; D005419:Flavonoids; D010936:Plant Extracts; D005557:Formaldehyde; D014147:Tramadol; D002351:Carrageenan; D019342:Acetic Acid