Olanzapine-induced weight gain and disturbances of lipid and glucose metabolism.
Among the atypical antipsychotics, clozapine and olanzapine are known to cause significant weight gain. Along with quetiapine, they may impair glucose metabolism and increase the risk for type 2 diabetes. They are also associated with a rise in triglyceride levels and an increased risk for coronary artery disease. Clinicians should take these risks seriously in prescribing these antipsychotics and employ intelligent safeguards if and when they use them.
eder-Ischia
Ursula
U
Department of Biological Psychiatry, Innsbruck University Clinics, Innsbruck, Austria.
Ebenbichler
Christoph
C
Fleischhacker
W Wolfgang
WW
D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced; D020738:Leptin / Q000096:biosynthesis; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors; D000077152:Olanzapine; D015430:Weight Gain / Q000187:drug effects*
D014150:Antipsychotic Agents; D020738:Leptin; D018377:Neurotransmitter Agents; D001569:Benzodiazepines; D000077152:Olanzapine