title: [Predictive value of detection of sentinel lymph nodes on lymphatic metastasis of non-small cell lung cancer].
abstract: OBJECTIVE
  The metastasis status of regional lymph node is an important prognostic factor of non-small cell lung cancer (NSCLC). Sentinel lymph node (SLN) mapping and biopsy is a quick and high efficient technique to intraoperatively detect occult micrometastatic disease, however, its application in NSCLC is immature. This study was designed to investigate the feasibility of detecting SLN in patients with NSCLC during radical surgery, and to evaluate its accuracy of predicting metastasis status of regional lymph node.
  
  
  METHODS
  Fifty patients with NSCLC underwent SLN detection. During radical operation, 4 ml of 1% isosulfan blue was injected into the lung tissue around the tumor at 3, 6, 9, and 12 o'clock sites. Location and number of blue dyed SLNs were recorded, and compared with pathologic results to calculate the accuracy and false negative rate of SLN detection.
  
  
  RESULTS
  Blue dyed SLNs were seen in 33 patients with a detection rate of 66.0%. SLNs located in N1 lymph node of 24 patients (72.7%), in N2 lymph node of 6 patients (18.2%), in both N1 and N2 lymph nodes of 3 patients (9.1%). Approved by pathology, the accuracy of SLN detection was 87.9% (29/33), the sensibility was 73.3% (11/15), the false negative rate was 26.7% (4/15).
  
  
  CONCLUSIONS
  SLN detection is valuable for predicting hilar and mediastinal lymph nodes metastases in NSCLC.
authors.affiliation: Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Zhu
authors.forename: Bao-Jiang
authors.initials: BJ
authors.lastname: Li
authors.forename: Shi-Yi
authors.initials: SY
authors.lastname: Zhang
authors.forename: Tie-Hua
authors.initials: TH
authors.lastname: Rong
authors.forename: Can-Guang
authors.initials: CG
authors.lastname: Zeng
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Yi
authors.initials: Y
authors.lastname: Hu
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Fu
authors.forename: Hao
authors.initials: H
authors.lastname: Long
authors.forename: Peng
authors.initials: P
authors.lastname: Lin
authors.forename: Si-Yu
authors.initials: SY
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Ming-Tian
authors.initials: MT
authors.lastname: Yang
authors.forename: Zhi-Fan
authors.initials: ZF
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D011013:Pneumonectomy; D011237:Predictive Value of Tests; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*