title: State-of-the-art management of nasopharyngeal carcinoma: current and future directions.
abstract: Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer. Approximately 70% of patients with newly diagnosed NPC present with locally advanced disease. Phase III clinical trials support the addition of chemotherapy to radiotherapy for the initial treatment of these patients. Once metastatic disease develops, practices become varied. Further experience needs to be gained with both targeted therapies and immunotherapy to gauge whether they will improve treatment outcomes in NPC.
authors.affiliation: Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.
authors.forename: M
authors.initials: M
authors.lastname: Agulnik
authors.forename: L L
authors.initials: LL
authors.lastname: Siu
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant / Q000639:trends; D003131:Combined Modality Therapy / Q000639:trends; D015316:Genetic Therapy / Q000639:trends; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents