[Genetic analysis of hematopoietic neoplasms].
Now dozens of genetic abnormalities have been identified in leukemias and lymphomas mainly through breakpoint analyses of the chromosome translocations recurrently observed in these tumors. After analyses on most of the major chromosome translocations have been completed, the current interests of genetic researches on hematopoietic tumors are unbalanced chromosome abnormalities that accompany gene deletions and amplifications among a variety of genetic mutations. In this regard, array based comparative genomic hybridization (CGH) and related techniques provide robust measures that enable high throughput genome-wide estimations of copy number changes for a large number of tumor samples. With these and other innovative techniques, identification of relevant genes for leukemogenesis and lymphomagenesis is being accelerated to provide more comprehensive understandings on development of these hematopoietic neoplasms.
Ogawa
Seishi
S
Department of Regeneration Medicine for Hematopoiesis, Faculty of Medicine, The University of Tokyo.
D006801:Humans; D007938:Leukemia / Q000235:genetics*; D019656:Loss of Heterozygosity; D008223:Lymphoma / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D040081:Protein Array Analysis