[Effect of hypothyroidism on the solid form of Ehrlich tumor in intact or castrated adult female mice].
The effect of hypothyroidism on the solid form of the Ehrlich tumor in intact or castrated adult female mice was studied. Hypothyroidism was induced by treatment with propylthiouracil (PTU). Forty mice were divided into four groups: castrated hypothyroid, intact hypothyroid, castrated euthyroid, and intact euthyroid. The mice were inoculated with suspension cells into the left footpad. The tumor growth curve was determined by measuring the inoculated footpad during 12 days. At the end of the experimental period the mice were sacrificed. Hypothyroidism was associated with a reduction in size of the tumor only in the castrated animals. Although the neoplastic growth was lower, mean nuclear diameter, number of nucleolar organizer regions (NORs), and area of mitosis were higher. In conclusion, hypothyroidism resulted in a delayed growth of the tumor, but it did not affect the malignant features of the neoplastic cells. In addition, the isolated effect of castration caused only mild alterations, whereas hypothyroidism associated with castration resulted in a more prominent delay in the growth rate of the Ehrlich tumor.
Silva
Alessandra Estrêla da
AE
Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, MG.
Serakides
Rogéria
R
Ferreira
Enio
E
Moraes
Jáder R Cappi
JR
Ocarino
Natália de Melo
Nde M
Cassali
Geovanni Dantas
GD
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000209:etiology* / Q000473:pathology*; D005260:Female; D007037:Hypothyroidism / Q000150:complications*; D051379:Mice; D010052:Ovariectomy