Identification of Tet 39, a novel class of tetracycline resistance determinant in Acinetobacter spp. of environmental and clinical origin.
A novel tetracycline resistance determinant named Tet 39 was found in unrelated Acinetobacter strains isolated from freshwater trout farms (n=4) and sewage (n=6) in Denmark, and from a clinical specimen in the Netherlands (n=1). The determinant was located on transferable plasmids and consisted of tetA(39), most likely conferring resistance by active efflux, and a putative repressor gene tetR(39).
Agersø
Y
Y
Danish Institute for Food and Veterinary Research, 1790 Copenhagen V., Denmark. ya@dfvf.dk
Guardabassi
L
L
D000150:Acinetobacter / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017756:Aquaculture; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012722:Sewage / Q000382:microbiology; D013752:Tetracycline / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D012722:Sewage; D013752:Tetracycline