[Influence of the growth phase of Neisseria meningitidis on the accumulation of antigens cross-reacting with human antigens in the culture].
The content of N. meningitidis antigens with epitopes cross-reacting with human antigens was studied in the dynamics of the meningococci cultivation. The absence of these antigens in the culture in the middle of the exponential phase of growth and their presence in the culture at the end of the stationary growth phase of growth were shown. Thus the expediency of using the culture in the middle of the exponential phase of growth for obtaining meningococcal (serogroups A, B and C) vaccines was demonstrated. The trend, found to be promising for the development of immunologically safe vaccines which contained no antigens having common epitopes with human antigens, was determined.
Basnak'ian
I A
IA
Aleksakhina
N N
NN
Iastrebova
N E
NE
Vaneeva
N P
NP
Kozlova
N N
NN
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D000942:Antigens, Bacterial / Q000032:analysis / Q000276:immunology*; D003429:Cross Reactions; D003470:Culture Media; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008589:Meningococcal Infections / Q000097:blood / Q000276:immunology / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D009345:Neisseria meningitidis / Q000254:growth & development / Q000276:immunology*; D009928:Organ Specificity / Q000276:immunology; D011817:Rabbits; D013997:Time Factors; D014611:Vaccination
D000907:Antibodies, Bacterial; D000941:Antigens; D000942:Antigens, Bacterial; D003470:Culture Media; D000939:Epitopes; D007074:Immunoglobulin G; D022401:Meningococcal Vaccines; D004676:Myelin Basic Protein