[Optimization of a HFR sorbent cartridge for high molecular weight uremic toxins].
HFR is a hemodiafiltration method with regeneration of the ultrafiltrate. It consists of a double chamber filter that separates convection from diffusion. The ultrafiltrate exits from the convective filter, passes through a sorbent cartridge where uremic toxins bind to the sorbent. The "purified" ultrafiltrate is then returned to the patient. This study undertook a series of in vitro and ex vivo experiments to optimize the conditions for maximal adsorption and treatment efficacy. An emphasis was placed on a resin only cartridge as previous studies suggested that some patients may be sensitive to the activated carbon, particularly if they are taking ACE inhibitors.
Wratten
M L
ML
Bellco SpA, Mirandola, Modena.
Sereni
L
L
Lupotti
M
M
Ghezzi
P M
PM
Atti
M
M
Formica
M
M
D000042:Absorption; D004867:Equipment Design; D017583:Hemodiafiltration / Q000295:instrumentation*; D006801:Humans; D008970:Molecular Weight; D014118:Toxins, Biological / Q000378:metabolism*; D014511:Uremia / Q000378:metabolism / Q000628:therapy*
D014118:Toxins, Biological