Mammotome: less invasive than ABBI with similar accuracy for early breast cancer detection.
We performed a prospective analysis of two consecutive biopsy cohorts investigated by the same team to compare the Mammotome system with the ABBI procedure. From April 1997 to August 2003 a series of 413 nonpalpable mammographic lesions in 387 women (median age 56 years, range 30-84 years) were stereotactically biopsied in the University Hospital of Basel, Switzerland. Until October 1999 the ABBI system was applied exclusively, it was subsequently superseded by the Mammotome device in our clinic. Main outcome measures were accuracy, technical demand, and morbidity. Sensitivity (97.3%/96.8%), negative predictive value (99.2%/98.7%), and diagnostic accuracy (99.4%/99.1%) regarding the detection of malignancy were excellent for both techniques (ABBI/ Mammotome). The Mammotome procedure was faster and less invasive, thus causing significantly less morbidity. The larger specimen obtained by the ABBI procedure resulted in more detailed histology. In conclusion, recommend the Mammotome system as the method of choice for detecting nonpalpable early breast cancer.
Weber
Walter P
WP
Department of Surgery, University of Basel, Spitalstrasse 21, Basel, CH-4031 Switzerland.
Zanetti
Rosanna
R
Langer
Igor
I
Dellas
Sophie
S
Zuber
Markus
M
Moch
Holger
H
Remmel
Eugenia
E
Oertli
Daniel
D
Wight
Edward
E
Marti
Walter R
WR
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000295:instrumentation*; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity