Transglutaminases as targets for pharmacological inhibition.
Transglutaminases (TGases), a family of enzymes that catalyze the formation of epsilon-(gamma-glutamyl)lysine isopeptide linkage, play an important physiological role in hemostasis, wound healing, assembly and remodeling of the extracellular matrix, cell signaling and apoptosis. Although many members of this class of enzymes have been known for decades, their role in various physiological and pathological processes is still a subject of substantial research and debate. Convincing evidence exists that TGases are involved in formation of cytotoxic proteinatious aggregates in Alzheimer's, Huntington's and other neurodegenerative diseases. However, it is not clear if elevated levels of TGases play a causative or protective role in several of these processes. Increased or defective TGase activity is a factor in cortical cataract formation, lamellar ichtyosis and fibrosis. TGase creates epitopes for the production of autoantibodies in celiac disease and possibly other autoimmune diseases. Another TGase, Factor XIIIa, is involved in the etiology of vascular diseases. Modulation of TGase activity through its selective inhibition may have therapeutic benefit in a wide variety of diseases. This paper will examine TGases as targets for the development of new therapeutics and review the progress in discovery of selective inhibitors of these enzymes.
Wodzinska
Jolanta M
JM
Innovative Drug Development, Apotex Research, Inc. 400 Ormont Drive, Toronto, Ontario M9L 1N9, Canada. jwodzins@apotex.ca
D002386:Cataract / Q000201:enzymology; D002446:Celiac Disease / Q000201:enzymology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry*; D005355:Fibrosis / Q000201:enzymology; D006801:Humans; D019636:Neurodegenerative Diseases / Q000201:enzymology; D011487:Protein Conformation; D013927:Thrombosis / Q000201:enzymology; D011503:Transglutaminases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000502:physiology*
D004791:Enzyme Inhibitors; D011503:Transglutaminases