A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase.
Hong
Hui
H
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Spencer
Jonathan B
JB
Porter
Jessica L
JL
Leadlay
Peter F
PF
Stinear
Tim
T
D000217:Acyltransferases / Q000235:genetics / Q000378:metabolism; D000595:Amino Acid Sequence; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D018942:Macrolides; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D019911:Mycobacterium ulcerans / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D048630:Polyketide Synthases / Q000235:genetics* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity
D001427:Bacterial Toxins; D007783:Lactones; D018942:Macrolides; C117218:mycolactone; C451488:mycolactone A; C451489:mycolactone B; D048630:Polyketide Synthases; D000217:Acyltransferases