Prevalence of inducible clindamycin resistance in macrolide-resistant Staphylococcus spp.
Between January 2002 and December 2003, macrolide-resistant isolates of Staphylococcus aureus (n = 45) and coagulase-negative staphylococci (CoNS; n = 75) from a Greek hospital were examined phenotypically for inducible clindamycin resistance. The constitutive macrolide resistance phenotype predominated (60%) in S. aureus, followed by the inducible (35%) and the clindamycin-susceptible (5%) phenotypes. In CoNS, the inducible phenotype was more common than the constitutive phenotype (50% vs. 41%). There was a significant incidence of inducible clindamycin resistance, and screening of all staphylococci is necessary in order to differentiate inducibly resistant isolates from those that are truly sensitive.
Fokas
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S
Sparta General Hospital, Microbiology, Sparta, Laconia, Greece. spifokas@yahoo.gr
Fokas
S
S
Tsironi
M
M
Kalkani
M
M
Dionysopouloy
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D003030:Coagulase / Q000032:analysis; D024881:Drug Resistance, Bacterial; D006115:Greece; D006761:Hospitals; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003030:Coagulase; D018942:Macrolides; D002981:Clindamycin