title: Low frequency of exon 3 PTPN11 mutations in adult de novo acute myeloid leukemia. Analysis of a consecutive series of 173 patients.
abstract: A total of 173 samples obtained from adult patients with de novo acute myeloid leukemia (AML) were assayed for exon 3 PTPN11 mutations by single strand conformation polymorphism (SSCP) analysis and direct sequencing. Only three monocytic leukemias had point mutations (1.73%).
authors.forename: Josep
authors.initials: J
authors.lastname: Nomdedéu
authors.forename: Maria T
authors.initials: MT
authors.lastname: Carricondo
authors.forename: Adriana
authors.initials: A
authors.lastname: Lasa
authors.forename: Granada
authors.initials: G
authors.lastname: Perea
authors.forename: Ana
authors.initials: A
authors.lastname: Aventin
authors.forename: Jorge
authors.initials: J
authors.lastname: Sierra
mesh_terms: D000208:Acute Disease; D000328:Adult; D002423:Cause of Death; D005091:Exons; D005260:Female; D005787:Gene Frequency; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D013030:Spain
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C516724:PTPN11 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases