title: The dynamics of histone H1 function in chromatin.
abstract: Over 80% of the nucleosomes in chromatin contain histone H1, a protein family known to affect the structure and activity of chromatin. Genetic studies and in vivo imaging experiments are changing the traditional view of H1 function and mechanism of action. H1 variants are partially redundant, mobile molecules that interact with nucleosomes as members of a dynamic protein network and serve as fine tuners of chromatin function.
authors.affiliation: Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. bustin@helix.nih.gov
authors.forename: Michael
authors.initials: M
authors.lastname: Bustin
authors.forename: Frédéric
authors.initials: F
authors.lastname: Catez
authors.forename: Jae-Hwan
authors.initials: JH
authors.lastname: Lim
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry* / Q000502:physiology; D004247:DNA / Q000737:chemistry; D004261:DNA Replication; D006657:Histones / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009707:Nucleosomes / Q000378:metabolism; D010641:Phenotype; D010940:Plant Proteins / Q000737:chemistry
chemical_list: D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D010940:Plant Proteins; D004247:DNA