A simple method for the alpha-oxygenation of aldehydes.
A mild, efficient and general method for the chemospecific alpha-oxygenation of aldehydes is described. Treatment of a series of aldehydes with N-tert-butyl-O-benzoyl hydroxylamine hydrochloride gives the corresponding alpha-oxygenated carbonyl via a proposed pericyclic rearrangement process.
Beshara
Cory S
CS
School of Chemistry, Cardiff University, PO Box 912, Cardiff, CF10 3TB, UK.
Hall
Adrian
A
Jenkins
Robert L
RL
Jones
Teyrnon C
TC
Parry
Rachael T
RT
Thomas
Stephen P
SP
Tomkinson
Nicholas C O
NC