Phospholipase C gamma in distinct regions of the ventral tegmental area differentially regulates morphine-induced locomotor activity.
Neurotrophic factors and the signaling pathways they activate play a role in mediating long-term molecular, cellular, and behavioral adaptations associated with drug addiction. Here we mimicked the biological response of phospholipase C-gamma (PLC gamma) induction in the ventral tegmental area (VTA) observed after chronic morphine using viral-mediated gene transfer. Using a behavioral sensitization paradigm, we demonstrate that microinjections of PLC gamma 1 into distinct (rostral vs. caudal) regions of the VTA result in differential locomotor responses to morphine.
Bolaños
Carlos A
CA
Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306-1270, USA. bolanos@psy.fsu.edu
Neve
Rachael L
RL
Nestler
Eric J
EJ
D000818:Animals; D007276:Injections, Intraventricular; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology*; D051966:Phospholipase C gamma; D051381:Rats; D017207:Rats, Sprague-Dawley; D010738:Type C Phospholipases / Q000008:administration & dosage*; D017557:Ventral Tegmental Area / Q000187:drug effects* / Q000502:physiology*
D009020:Morphine; D010738:Type C Phospholipases; D051966:Phospholipase C gamma