Interleukin 4, interleukin 6 and interleukin 10 polymorphisms in children with acute and chronic immune thrombocytopenic purpura.
Immune thrombocytopenic purpura (ITP) is an immune-mediated disorder. We investigated the polymorphisms of interleukin (IL)-4 intron 3, IL-6 (-572 G/C), and IL-10 (-627 C/A) in 50 children with acute ITP, 30 children with chronic TIP, and 100 healthy individuals. There were significant differences in the RP1/RP2 genotype proportion (P = 0.04) and the RP2 allelic frequency (P = 0.03) of IL-4 intron 3 and the A/C genotype proportion (P = 0.01) of IL-10 (-627) between children with chronic ITP and controls. This finding suggests that the IL-4 intron 3 and IL-10 (-627) polymorphisms contribute to the susceptibility of developing childhood chronic ITP.
Wu
Kang-Hsi
KH
Department of Paediatrics, China Medical University Hospital, Taichung 404, Taiwan.
Peng
Ching-Tien
CT
Li
Tsai-Chung
TC
Wan
Lei
L
Tsai
Chang-Hai
CH
Lan
Shou-Jen
SJ
Chang
Ming-Cheng
MC
Tsai
Fuu-Jen
FJ
D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005787:Gene Frequency; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D007378:Interleukins / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000235:genetics*
D015850:Interleukin-6; D007378:Interleukins; D016753:Interleukin-10; D015847:Interleukin-4