The effect of acetylshikonin isolated from Lithospermum canescens roots on tumor-induced cutaneous angiogenesis.
This study has demonstrated that acetylshikonin (ACS), the isolated ingredient from Lithospermum canescens Lehm. roots, in a daily dose of 200 microg for 3 days, inhibited cutaneous angiogenesis induced by L-1 sarcoma cells in Balb/c mice.
Pietrosiuk
Agnieszka
A
Department of Biology and Pharmaceutical Botany, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland
Furmanowa
Mirosława
M
Skopińiska-Rózewska
Ewa
E
Sommer
Ewa
E
Skurzak
Henryk
H
Bany
Janusz
J
D020533:Angiogenesis Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology*; D029684:Lithospermum; D051379:Mice; D008807:Mice, Inbred BALB C; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots; D012513:Sarcoma, Experimental / Q000098:blood supply; D012867:Skin / Q000098:blood supply*; D012878:Skin Neoplasms / Q000098:blood supply; D014407:Tumor Cells, Cultured
D020533:Angiogenesis Inhibitors; D000880:Anthraquinones; D009285:Naphthoquinones; D010936:Plant Extracts; C073944:acetylshikonin