title: Vertically acquired neonatal citrobacter brain abscess - case report and review of the literature.
abstract: Vertically acquired citrobacter meningitis in the neonate is very rare and carries a very high mortality and morbidity. Overall, approximately 30% of neonates with Citrobacter meningitis die and 50% sustain some damage to the CNS. The authors describe a case of a newborn with Citrobacter koseri meningitis with multiple brain abscesses, with a successful outcome following multiple burr-hole aspirations and prolonged antibiotic therapy. An aggressive surgical approach combined with intravenous antibiotics (including imipenems, to which the organism is very sensitive) for a minimum of 4 weeks appears to improve the outcome of infection with this virulent organism.
authors.affiliation: Department of Neurosurgery, Neurosciences Center, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Agrawal
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Mahapatra
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001922:Brain Abscess / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D002701:Chloramphenicol / Q000627:therapeutic use; D015377:Cilastatin / Q000627:therapeutic use; D041041:Citrobacter koseri; D004359:Drug Therapy, Combination; D004756:Enterobacteriaceae Infections / Q000473:pathology / Q000628:therapy / Q000635:transmission*; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D016920:Meningitis, Bacterial / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D013396:Suction
chemical_list: D000900:Anti-Bacterial Agents; D015377:Cilastatin; D002701:Chloramphenicol; D015378:Imipenem