title: Cortical involvement in Marchiafava-Bignami disease.
abstract: Marchiafava-Bignami disease (MBD), a rare complication of chronic alcoholism, is characterized by primary demyelination of the corpus callosum. We report two cases of MBD in which fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging studies revealed symmetrical hyperintense lesions in the cerebral cortex (particularly in the lateral-frontal regions) in addition to the callosal lesions, which suggests an association of diffuse cortical lesions such as Morel's laminar sclerosis with MBD.
authors.affiliation: Department of Neurology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Johkura
authors.forename: Makoto
authors.initials: M
authors.lastname: Naito
authors.forename: Takayuki
authors.initials: T
authors.lastname: Naka
mesh_terms: D000368:Aged; D000437:Alcoholism / Q000150:complications*; D002540:Cerebral Cortex / Q000473:pathology*; D002908:Chronic Disease; D003337:Corpus Callosum / Q000473:pathology*; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000209:etiology*; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged