Preparation of enamides via palladium-catalyzed amidation of enol tosylates.
[reaction: see text] A Pd-catalyzed coupling of enol tosylates and amides has been developed. Ligand screening revealed dipf as the most general ligand for this transformation. A variety of enol tosylates were coupled to an array of enamides in 58-97% yield.
Klapars
Artis
A
Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. artis_klapars@merck.com
Campos
Kevin R
KR
Chen
Cheng-Yi
CY
Volante
Ralph P
RP
D000577:Amides / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D014105:Tosyl Compounds / Q000737:chemistry*
D000577:Amides; D014105:Tosyl Compounds; D010165:Palladium