Formalin-induced pain is reduced in sigma(1) receptor knockout mice.
The role of sigma1 receptors in non-acute pain has not been explored. In this study we show that both phases of formalin-induced pain were reduced by approximately 55% in sigma1 receptor knockout mice in comparison to wild-type animals. These results suggest that the tonic pain induced by formalin is altered in mice lacking sigma1 receptors, and highlight the potential usefulness of further studies of the role of sigma1 receptors in models of non-acute pain.
Cendán
Cruz Miguel
CM
Department of Pharmacology and Institute of Neurosciences, School of Medicine, University of Granada, Avenida de Madrid 12, 18012 Granada, Spain.
Pujalte
José Miguel
JM
Portillo-Salido
Enrique
E
Montoliu
Lluís
L
Baeyens
José M
JM
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D005557:Formaldehyde; D005838:Genotype; D006614:Hindlimb / Q000187:drug effects / Q000503:physiopathology; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D017480:Receptors, sigma / Q000235:genetics / Q000502:physiology*; D013997:Time Factors; D000097605:Sigma-1 Receptor
D005557:Formaldehyde; D017480:Receptors, sigma; D000097605:Sigma-1 Receptor