title: Biliary atresia: feasibility of mangafodipir trisodium-enhanced MR cholangiography for evaluation.
abstract: The study was approved by the institutional review board, and informed consent was obtained from the patients' parents. Twenty-three consecutive infants suspected of having biliary atresia (BA) were prospectively examined by using mangafodipir trisodium (Mn-DPDP)-enhanced magnetic resonance (MR) cholangiography. Sequential T1-weighted spoiled gradient-echo MR cholangiograms were obtained 1, 2, and 3 hours after intravenous administration of Mn-DPDP. The possibility of BA was excluded if bowel excretion of contrast material was noted at contrast material-enhanced MR cholangiography. The diagnostic specificity and accuracy of contrast-enhanced MR cholangiography were compared with those of conventional MR cholangiography, technetium 99m Tc ((99m)Tc)-disofenin (DISIDA) scintigraphy, and the triangular cord sign at ultrasonography (US). MR cholangiography was used to accurately distinguish four cases of BA from 19 cases of other cholestatic liver diseases, without false-positive results. Conventional MR cholangiography, (99m)Tc-DISIDA scintigraphy, and the triangular cord sign at US respectively yielded false-positive results of 42% (eight of 19 infants), 35% (six of 17 infants), and 11% (two of 19 infants) in patients without BA. Mn-DPDP-enhanced MR cholangiography appears to be a promising modality for early diagnosis of BA as the cause of neonatal cholestasis.
authors.affiliation: Department of Radiology, Kyungpook National University School of Medicine, Samduk 2Ga, Jung-Gu, Daegu 700-721, Republic of Korea.
authors.forename: Hun Kyu
authors.initials: HK
authors.lastname: Ryeom
authors.forename: Byung Ho
authors.initials: BH
authors.lastname: Choe
authors.forename: Jong Yeol
authors.initials: JY
authors.lastname: Kim
authors.forename: Soonhak
authors.initials: S
authors.lastname: Kwon
authors.forename: Cheol Woo
authors.initials: CW
authors.lastname: Ko
authors.forename: Heng Mi
authors.initials: HM
authors.lastname: Kim
authors.forename: Sang Bum
authors.initials: SB
authors.lastname: Lee
authors.forename: Duk Sik
authors.initials: DS
authors.lastname: Kang
mesh_terms: D001656:Biliary Atresia / Q000175:diagnosis*; D002758:Cholangiography / Q000379:methods*; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid