title: Efficacy of CT-guided percutaneous needle biopsy in the diagnosis of malignant lymphoma at first presentation.
abstract: OBJECTIVE
  The aim of this study was to evaluate retrospectively the accuracy and reliability of CT-guided percutaneous biopsy as an alternative to surgical biopsy in a selected population of patients without superficial enlarged lymph nodes and a final diagnosis of malignant lymphoma at first presentation.
  
  
  METHODS
  The results of 145 CT-guided needle biopsies in 137 patients with malignant lymphoma at its first presentation and without superficial enlarged lymph nodes were analyzed retrospectively. Biopsies were performed in 24 patients with Hodgkin's disease (HD) and 113 with non-Hodgkin lymphoma (NHL). Factors such as patient's sex, age, type of lymphoma and biopsy site were evaluated to detect factors that could influence the success rate of the procedure.
  
  
  RESULTS
  Biopsy specimens were diagnostic in 101 of the 113 patients with NHL and in 18 of the 24 patients with HD. Repeating of a previously nondiagnostic biopsy was successful in 7 out of 13 patients with NHL. No positive results were obtained, repeating the inconclusive biopsy in six patients with HD.
  
  
  CONCLUSIONS
  Our results suggest that percutaneous CT-guided biopsy is a useful and reliable tool in the diagnosis and classification of malignant lymphomas in patients without superficial lymphadenopathy and can be considered as an alternative to surgical sampling. However, little advantages were obtained, repeating previously inconclusive biopsies: In these cases, surgical sampling is mandatory.
authors.affiliation: Department of Radiology, Centro di Riferimento Oncologico IRCCS, Via Pedemontana Occ.le 12, Aviano 33081, Italy. lbalestreri@cro.it
authors.forename: Luca
authors.initials: L
authors.lastname: Balestreri
authors.forename: Sandro
authors.initials: S
authors.lastname: Morassut
authors.forename: Daniele
authors.initials: D
authors.lastname: Bernardi
authors.forename: Marcello
authors.initials: M
authors.lastname: Tavio
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.forename: Annunziata
authors.initials: A
authors.lastname: Gloghini
authors.forename: Antonino
authors.initials: A
authors.lastname: Carbone
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods / Q000592:standards; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008221:Lymphoid Tissue / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed