The many faces of HIV nephropathy: results of the disease and consequences of treatment.
Impaired renal function is a consequence of HIV infection, even without a defined AIDS syndrome. While collapsing focal and segmental glomerulosclerosis is the clinical entity that is associated most commonly with progressive disease, the spectrum of renal involvement in patients who are HIV positive is expanding. In addition, consequences of anti-retroviral therapy are well-documented in the literature. The current case illustrates an unusual primary renal pathology picture presumably related to his underlying HIV disease and compounded by the unexpected consequences of anti-retroviral therapy, noted long after discontinuation of the medication.
Lam
Chun
C
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215-USA.
Stillman
Isaac E
IE
Steinman
Theodore I
TI
D016263:AIDS-Associated Nephropathy / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D004334:Drug Administration Schedule; D005920:Glomerular Mesangium / Q000378:metabolism; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron
D007070:Immunoglobulin A