title: Behavioral and neurochemical repercussions of hippocampal network activity blockade during the neonatal period.
abstract: Early destruction of the ventral hippocampus from postnatal day 7 (P7) has been shown to induce behavioral alterations in post-pubertal rats, similar to those observed in models for schizophrenia. Using a single injection of tetanus toxin into the ventral hippocampus at P1, we tested the consequences of an early neonatal activity deprivation (<P7) on behavioral and neurochemical parameters of pre- and post-pubertal rats. We found no significant differences in either behavioral or biochemical pattern, indicating that an early neonate neural activity blockade does not induce behavioral alterations in pre- and post-puberty rats.
authors.affiliation: Department of Pharmacology, Göteborg University, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Ponten
authors.forename: Kirsten
authors.initials: K
authors.lastname: Sönniksen
authors.forename: Therése
authors.initials: T
authors.lastname: Abrahamsson
authors.forename: Nicholas
authors.initials: N
authors.lastname: Waters
authors.forename: Bengt
authors.initials: B
authors.lastname: Gustafsson
authors.forename: Eric
authors.initials: E
authors.lastname: Hanse
authors.forename: Laurent
authors.initials: L
authors.lastname: Groc
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000254:growth & development* / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D009415:Nerve Net / Q000254:growth & development* / Q000378:metabolism* / Q000503:physiopathology; D009638:Norepinephrine / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012559:Schizophrenia / Q000209:etiology; D012701:Serotonin / Q000378:metabolism; D012741:Sexual Maturation / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D013744:Tetanus Toxin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D013744:Tetanus Toxin; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D004298:Dopamine; D009638:Norepinephrine