title: Takayasu arteritis: clinical features and management: report of 272 cases.
abstract: BACKGROUND
  Takayasu's arteritis is a condition of unknown aetiology with an unpredictable natural history. Most of the literature available has originated from Asia, with a few contributions from Africa where the pattern of the disease may be different. This is a single institution's experience review.
  
  
  METHODS
  Data were obtained retrospectively from the angiographic and medical records of patients treated at Groote Schuur Hospital over the period 1952-2002. The criteria for inclusion were those proposed by the Aortitis Syndrome Research Committee of Japan and the American College of Rheumatology.
  
  
  RESULTS
  Two hundred and seventy-two patients were identified. The mean age at presentation was 25 years (range 14-66 years) and 75% were female. Only 8% were Caucasian. Hypertension was the most common presentation (77%) and was usually a consequence of renal artery stenosis or aortic coarctation. Cardiac failure was the most common problem. Cerebrovascular symptoms were recorded in 20%. Convincing evidence of tuberculosis was present in 20%. The entire aorta was involved in 70% of cases. Thirty per cent had aortic bifurcation involvement. Occlusions were noted in 93% and aneurysms in 46%. Vascular reconstruction was performed on 115 occasions in 99 patients, with an operative mortality of 4%. Cardiac failure was the usual cause of death. One hundred and six patients (39%) were followed for a minimum of 5 years. No further progression of disease was noted in 70 patients.
  
  
  CONCLUSIONS
  The natural history and prognosis of Takayasu's arteritis still remain poorly defined.
authors.affiliation: Vascular Unit, Groote Schuur Hospital and the Faculty of Health Sciences (Cape Town), Cape Town, Western Cape, South Africa. bibombe@iinet.net.au
authors.forename: Bibombe P
authors.initials: BP
authors.lastname: Mwipatayi
authors.forename: Peter C
authors.initials: PC
authors.lastname: Jeffery
authors.forename: Steve J
authors.initials: SJ
authors.lastname: Beningfield
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Matley
authors.forename: Naid G
authors.initials: NG
authors.lastname: Naidoo
authors.forename: Abdullah A
authors.initials: AA
authors.lastname: Kalla
authors.forename: Del
authors.initials: D
authors.lastname: Kahn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013019:South Africa; D013625:Takayasu Arteritis / Q000150:complications / Q000503:physiopathology*