[Celecoxib and Tramadol as an alternative osteoarthrosis therapy in patients with NSAID gastropathy].
To determine whether it is possible to continue the anti-inflammatory NSAID therapy of osteoarthrosis patients with the NSAID-induced duodenal ulcer. The results of the treatment of 38 patients with osteoarthrosis of II-III degrees in which the NSAID treatment was complicated with duodenal ulcers were analyzed. The treatment of 20 osteoarthrosis patients was carried out with the help of Celecoxib while 18 patients were on Tramadol as an analgesic therapy against a standard antiulcer therapy. The efficacy of osteoarthrosis treatment was assessed based on the pain syndrome dynamics by the VAS and functional Lequin test; the efficacy of duodenal ulcer treatment was assessed on the basis of clinical signs dynamics under EGD (esophagogastroduodenoscopy). A clinical remission (the endoscopy confirmed the healing of the ulcerous affection) was achieved in 19 Celecoxib patients with duodenal ulcer and osteoarthrosis, and 18 Tramadol patients with osteoarthrosis and duodenal ulcer against a standard antiulcer therapy. Celecoxib can serve as a drug of choice for continuing the anti-inflammatory and analgesic therapy in patients with osteoarthrosis and NSAID gastropathy.
Lazebnik
L B
LB
Drozdov
V N
VN
Li
I A
IA
Kolomiets
E V
EV
D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000139:chemically induced*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D008297:Male; D010003:Osteoarthritis / Q000150:complications / Q000188:drug therapy*; D011720:Pyrazoles / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*; D014147:Tramadol / Q000627:therapeutic use*; D016896:Treatment Outcome
D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D014147:Tramadol; D000068579:Celecoxib