Correlation between omega and psi dihedral angles in protein structures.
The planarity of the peptide group is one of the fundamental features of protein structure that is described in every chemistry and biochemistry textbook. By surveying a dataset of 163 atomic resolution protein structures we here identify the stereochemical conditions that favor significant deformations of peptide bond planarity. In particular, we demonstrate that the values of the omega dihedral angle are strictly correlated to the values of the adjacent psi angle. This trend is also observed in highly strained states such as those occurring in vicinal disulfide bridges. These findings provide direct evidence for the mutual influence of the geometrical parameters that describe the protein structure.
Esposito
Luciana
L
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, I-80134 Napoli, Italy.
De Simone
Alfonso
A
Zagari
Adriana
A
Vitagliano
Luigi
L
D030562:Databases, Protein; D008958:Models, Molecular; D015394:Molecular Structure; D011487:Protein Conformation; D013223:Statistics as Topic