title: Long-term follow-up of double kidney transplantation using a score for evaluation of marginal donors*.
abstract: To face the problem of organ shortage, marginal grafts from 36 donors which had been refused for single transplantation were used for double-kidney transplantation (D-KTX). The residual kidney function was evaluated by the Muenster double kidney score. In a 5-year period kidneys from 57 marginal donors were transferred to our center. According to the Muenster double kidney score, the kidneys were distributed to single, double or refusal of transplantation. Sixteen male and 20 female donors were used for D-KTX (70+/-9.3 years, range 53-86). Thirty-six recipients (23 male, 13 female; 60.5+/-6.9 years) were double-grafted within a mean cold ischemic time of 19.3+/-3.4 h. Immunosuppression varied according to human leukocyte antigen (HLA)-mismatch. Graft and patient survival was observed up to 5 years. Initial graft function rate was 69%. Two recipients had a primary nonfunction (5.5%) and nine recipients suffered from delayed graft function (DGF; 25%). One-, 2-, 3-year creatinine values were 1.6 +/- 0.5, 1.9 +/- 0.6 and 2.2 +/- 0.7 mg/dl, respectively. One-, 2-, 3-, 4- and 5-year function rate was 93.7%, 93.5%, 81.8%, 76.4% and 55%, respectively (n = 32, 31, 22, 17 and 9). Acute rejection rate was 19%. 4 grafts were lost to chronic rejection (months 22, 25, 28, 48). Six (16%) died in long-term follow-up because of pneumonia (n = 2), carcinoma of the lung (n = 1), cardial complications (n = 2) and multiorgan failure (n = 1). D-KTX is a safe way to face the problem of organ shortage. However, a score for preoperative evaluation of marginal kidneys for single, dual or refusal of transplantation is essential.
authors.affiliation: Department of General Surgery, Muenster University Hospital, Germany. wolterh@uni-muenster.de
authors.forename: Heiner H
authors.initials: HH
authors.lastname: Wolters
authors.forename: Daniel
authors.initials: D
authors.lastname: Palmes
authors.forename: Stefan
authors.initials: S
authors.lastname: Heidenreich
authors.forename: Christian
authors.initials: C
authors.lastname: August
authors.forename: Jens
authors.initials: J
authors.lastname: Brockmann
authors.forename: Norbert
authors.initials: N
authors.lastname: Senninger
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Dietl
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D046148:Donor Selection; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000503:physiopathology; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D016019:Survival Analysis; D014019:Tissue Donors