Classic follicular dendritic reticulum cell tumor of the lymph node developing in a patient with a previous inflammatory pseudotumor-like proliferation.
Inflammatory pseudotumor (IPT) and follicular dendritic reticulum cell tumor (FDRCT) are rare entities of the lymph node characterized by spindle-cell proliferation. We report a case of a 31-year-old woman, who was admitted for biopsy of a lymph node in the left submandibular area. The microscopic examination revealed a proliferation of spindle cells, partially replacing the normal lymph node architecture, suggestive of an IPT. The preserved peripheral portion showed follicular hyperplasia with Castleman-like appearance. Six years later she presented with a new enlargement in the same submandibular area. The nodule was removed, and a diagnosis of a classic FDRCT of the lymph node was made. The present case is remarkable, and clinicopathological data show that IPT-like proliferations could be in some case an early presentation of FDRCT.
Cossu
Antonio
A
Institute of Anatomic Pathology and Histopathology, University of Sassari, 07100 Sassaru, Italy. cossu@uniss.it
Lissia
Amelia
A
Dedola
Maria Filomena
MF
Deiana
Angelo
A
Faedda
Rossana
R
Palmieri
Giuseppe
G
Tanda
Francesco
F
D000328:Adult; D020566:Dendritic Cells, Follicular / Q000473:pathology*; D005260:Female; D006104:Granuloma, Plasma Cell / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology* / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*