title: Second trimester abortion using isosorbide mononitrate in addition to gemeprost compared with gemeprost alone: a double-blind randomized, placebo-controlled multicenter trial.
abstract: OBJECTIVE
  We aimed to determine whether second-trimester abortion using isosorbide mononitrate (IMN) in addition to gemeprost is more effective and reduces side effects compared with gemeprost alone.
  
  
  METHODS
  Eighty women who were age 13 to 23 weeks' gestation were randomly assigned to receive per vaginam either IMN 40 mg (group 1, 40 women) or placebo (group 2, 40 women) in addition to gemeprost 1 mg up to 3 times daily 3 hours apart for 2 days. Analysis of variance, a chi 2 test, and a multivariate analysis were performed.
  
  
  RESULTS
  Of the 72 women analyzed, 68% (group 1) and 38% (group 2) underwent abortion within day 1 (P < .05). However, group 1 was associated with more headache (18% of women) 3 hours after induction compared to group 2 (0% of women, P = .038).
  
  
  CONCLUSIONS
  IMN in addition to gemeprost is effective for second-trimester abortion, but is associated with more headache compared with gemeprost alone.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Eppel
authors.forename: Fabio
authors.initials: F
authors.lastname: Facchinetti
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Schleussner
authors.forename: Federica
authors.initials: F
authors.lastname: Piccinini
authors.forename: Cristina
authors.initials: C
authors.lastname: Pizzi
authors.forename: Doris M
authors.initials: DM
authors.lastname: Gruber
authors.forename: Barbara
authors.initials: B
authors.lastname: Schneider
authors.forename: Walter
authors.initials: W
authors.lastname: Tschugguel
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000028:Abortion, Induced / Q000379:methods*; D000282:Administration, Intravaginal; D000527:Alprostadil / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D015999:Multivariate Analysis; D020030:Nitric Oxide Donors / Q000008:administration & dosage*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D020030:Nitric Oxide Donors; C021182:gemeprost; D000527:Alprostadil; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate