[FTIR study on normal and cancerous lung tissues].
Tissues of cancerous and normal lungs were analysed directly and fast by Fourier transform infrared spectroscopy with OMNI-sampler. The result indicated that some remarkable spectral differences were among normal and cancerous lung tissues in frequency, intensity and shape of the absorption peaks. These facts indicated significant differences of content, structure and conformation of proteins, nucleic acids and lipids in different types of lung tissues. The present results suggested that Fourier transform infrared spectrometry (FTIR) could show the properties of normal and cancerous lung tissues at the molecular level. It was able to provide rich and reliable information for investigation of normal and cancerous lung tissues and could be used as a convenient and reliable diagnostic tool for some tumors.
Cheng
Cun-gui
CG
College of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, China.
Shi
Hong-qi
HQ
Zhu
Xiao-jun
XJ
Zheng
Rong-quan
RQ
Zhu
Shou-tian
ST
D002283:Carcinoma, Bronchogenic / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008168:Lung / Q000737:chemistry*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009363:Neoplasm Proteins / Q000737:chemistry; D009696:Nucleic Acids / Q000737:chemistry; D012016:Reference Values; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
D008055:Lipids; D009363:Neoplasm Proteins; D009696:Nucleic Acids