[Relationship between heat stress protein 70 gene polymorphisms and the risk of acute mountain sickness].
OBJECTIVE
To investigate the relationship between heat stress proteins 70 (HSPs70) gene polymorphism and the risk of acute mountain sickness.


METHODS
Fifty-six soldiers with acute mountain sickness and 173 soldiers without that were chosen as cases and controls. HSP70-1, HSP70-2 genotypes were analyzed by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.


RESULTS
The HSP70-1 polymorphism was similar in two groups. The genotype frequency of HSP70-2 B/B in acute mountain sickness group (23.2%) was significantly higher than that in the control (6.9%, P < 0.05, OR = 4.02).


CONCLUSIONS
There is a significantly increased association of HSP70-2 B/B genotype with the risk of acute mountain sickness. Individuals with HSP70-2 B/B genotype may have weaker adaptive ability than those without this genotype under altitude stress. The results contribute to provide scientific bases for finding these individuals in specified occupational people, ensuring their health and enhancing work efficiency.
Li
Fang-Ze
FZ
Clinical Laboratory of the Hospital of the General Armed Police Force of Sichuan, Chengdu 610041, China.
Zhou
Fang
F
Jiang
Chang-Zheng
CZ
Sun
Su-Yong
SY
He
Mei-An
MA
Zhang
Shu-Yu
SY
Liao
Rong
R
Zeng
Hua-Song
HS
Wu
Yi-Ming
YM
Wu
Tang-Chun
TC
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D055815:Young Adult
D018840:HSP70 Heat-Shock Proteins