Steroids' transformations in Penicillium notatum culture.
The application of Penicillium notatum genus for biotransformations of steroids has been investigated. The reactions observed include insertion of an oxygen atom into D-ring of steroids, 15alpha-hydroxylation of 17alpha-methyl testosterone derivatives, ester bond hydrolysis, and degradation of a testosterone derivatives side chain. Microbial production of testolactones, the biologically active compounds, was also achieved using this strain in up to 98% yield.
Bartmańska
Agnieszka
A
Department of Chemistry, Agricultural University, Norwida 25, 50-375 Wrocław, Poland. aproch@ozi.ar.wroc.pl
Dmochowska-Gładysz
Jadwiga
J
Huszcza
Ewa
E
D000735:Androstenedione / Q000737:chemistry; D018929:Cell Culture Techniques / Q000379:methods; D002855:Chromatography, Thin Layer; D002942:Circular Dichroism; D004952:Esters; D005003:Ethisterone / Q000652:urine; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008696:Methandrostenolone / Q000737:chemistry; D008777:Methyltestosterone / Q000737:chemistry; D008956:Models, Chemical; D009277:Nandrolone / Q000737:chemistry; D010100:Oxygen / Q000378:metabolism; D010407:Penicillium / Q000378:metabolism*; D011374:Progesterone / Q000737:chemistry; D013053:Spectrophotometry; D013055:Spectrophotometry, Infrared; D013739:Testosterone / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D043343:Testosterone Propionate / Q000737:chemistry
D004952:Esters; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; C013915:boldenone; D009277:Nandrolone; D008696:Methandrostenolone; D005003:Ethisterone; D010100:Oxygen; D008777:Methyltestosterone; D043343:Testosterone Propionate