[Ca2+ -induced cell injury of cardiomyocyte].
Pathogenesis of ischemia/reperfusion injury involves Ca(2+) -induced cell injury. Elevated intracellular Ca(2+) concentration at the reperfusion activates the Ca(2+) dependent protease, calpain and increases the generation of reactive oxygen species (ROS) in mitochondria, which cause cell injury in ischemia/reperfusion.
Morita
T
T
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine.
Otsu
K
K
Hori
M
M