title: A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
authors.forename: Hui
authors.initials: H
authors.lastname: Hong
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Spencer
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Porter
authors.forename: Peter F
authors.initials: PF
authors.lastname: Leadlay
authors.forename: Tim
authors.initials: T
authors.lastname: Stinear
mesh_terms: D000217:Acyltransferases / Q000235:genetics / Q000378:metabolism; D000595:Amino Acid Sequence; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D018942:Macrolides; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D019911:Mycobacterium ulcerans / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D048630:Polyketide Synthases / Q000235:genetics* / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity
chemical_list: D001427:Bacterial Toxins; D007783:Lactones; D018942:Macrolides; C117218:mycolactone; C451488:mycolactone A; C451489:mycolactone B; D048630:Polyketide Synthases; D000217:Acyltransferases