[Association of plasma homocysteine and cystathionine beta-synthase polymorphism with cerebral thrombosis].
OBJECTIVE
To study the association of plasma homocysteine (Hcy) and polymorphism and cystathionine beta-synthase (CBS) with cerebral thrombosis.


METHODS
Eighty-seven patients with first-ever acute cerebral thrombosis and 80 control subjects were examined for plasma Hcy levels using high-performance liquid chromatography-fluorescence detection and for CBS polymorphism determined by amplification refractory mutation system.


RESULTS
The fasting plasma Hcy level was l5.28 micromol/L (95% CI 14.37-16.19 micromol/L) in the patient group, higher than that in the control group (11.32 micromol/L, 95% C1 10.47-12.16 micromol/L, P<0.001). Plasma Hcy levels varied with different genotypes. No difference in genotype or allele frequencies was noted between patient group and control group (P>0.05).


CONCLUSIONS
Common mutations in CBS G919A and CBS T833C lead to hyperhomocysteinemia, which, instead of common mutations in CBS, is more directly associated with increased risk of cerebral thrombosis.
Shao
Yan
Y
Department of Neurology, First People's Hospital of Foshan City, Foshan 528000, China. shaoyan2001@21cn.com
Zhang
Cheng-Guo
CG
Cui
Jin-Huan
JH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003541:Cystathionine beta-Synthase / Q000097:blood* / Q000235:genetics; D005260:Female; D006710:Homocysteine / Q000097:blood* / Q000235:genetics; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D006710:Homocysteine; D003541:Cystathionine beta-Synthase