title: [Oncogenic osteomalacia: the role of the phosphatonins. Diagnostic usefulness of the Fibroblast Growth Factor 23 measurement in one patient].
abstract: BACKGROUND
  Oncogenic osteomalacia (OO) is a rare paraneoplastic syndrome characterized by severe hypophosphatemia induced by phosphaturic factors which are secreted by some tumors of mesenchymal origin. Fibroblast Growth Factor 23 (FGF-23) belongs to this family. Measurement of FGF-23 might improve the diagnosis of OO.
  
  
  METHODS
  We report the case of 71-year-old Caucasian man who had a history of severe osteomalacia with multiples fractures and extreme hypophosphatemia with hyperphosphaturia and normal serum calcium level. Serum FGF-23 was 199 RU/ml (N < 100 RU/ml). The tumor, detected by F-18 FDG PET/CT SCAN was localized in the mandible. Surgical removal of the tumor relieved all symptoms with normalization of serum phosphate levels within 3 days after surgery.
  
  
  CONCLUSIONS
  We conclude that FGF-23 measurement is likely to be of considerable importance for facilitating early diagnosis of OO.
authors.affiliation: Service de médecine interne, hôpital Jean-Minjoz, boulevard Fleming 25030 Besançon cedex, France. jean-louis.dupond@ufc-chu.univ-fcomte.fr
authors.forename: J L
authors.initials: JL
authors.lastname: Dupond
authors.forename: N
authors.initials: N
authors.lastname: Magy
authors.forename: M
authors.initials: M
authors.lastname: Mahammedi
authors.forename: D
authors.initials: D
authors.lastname: Prie
authors.forename: H
authors.initials: H
authors.lastname: Gil
authors.forename: N
authors.initials: N
authors.lastname: Meaux-Ruault
authors.forename: B
authors.initials: B
authors.lastname: Kantelip
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D008297:Male; D008334:Mandible / Q000473:pathology; D010018:Osteomalacia / Q000175:diagnosis* / Q000209:etiology*; D049268:Positron-Emission Tomography
chemical_list: D015415:Biomarkers; C000717427:FGF23 protein, human; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23