Mechanisms of incisional pain.
Postoperative, incisional pain is a unique but common form of acute pain. Because effective postoperative analgesia reduces morbidity following surgery, new treatments continue to be sought. It is through the development of investigational models and studies of the mechanisms that perioperative medicine can be advanced. This article reviews studies on a rat plantar hindpaw model for postoperative pain and proposes mechanisms for enhanced excitability of sensory neurons caused by incisions.
Brennan
Timothy J
TJ
Departments of Anesthesia and Pharmacology, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242-1079, USA. tim-brennan@uiowa.edu
Zahn
Peter K
PK
Pogatzki-Zahn
Esther M
EM
D000758:Anesthesia; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology; D007813:Laparotomy; D010149:Postoperative Pain / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy*; D013514:Surgical Procedures, Operative / Q000009:adverse effects*