When kinases meet mathematics: the systems biology of MAPK signalling.
The mitogen activated protein kinase/extracellular signal regulated kinase pathway regulates fundamental cellular function such as cell proliferation, survival, differentiation and motility, raising the question how these diverse functions are specified and coordinated. They are encoded through the activation kinetics of the pathway, a multitude of feedback loops, scaffold proteins, subcellular compartmentalisation, and crosstalk with other pathways. These regulatory motifs alone or in combination can generate a multitude of complex behaviour. Systems biology tries to decode this complexity through mathematical modelling and prediction in order to gain a deeper insight into the inner works of signalling networks.
Kolch
Walter
W
Sir Henry Wellcome Functional Genomics Facility, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK. wkolch@beatson.gla.ac.uk
Calder
Muffy
M
Gilbert
David
D
D000818:Animals; D019295:Computational Biology; D025461:Feedback, Physiological; D006801:Humans; D007700:Kinetics; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D008962:Models, Theoretical; D010770:Phosphotransferases / Q000502:physiology
D010770:Phosphotransferases