[Genetic polymorphism of pyruvate dehydrogenase kinase 4 (PDK4), paraoxonase 2 (PON2), and fatty acid binding protein 2 (FABP2) in the NIDDM population of Senegal].
We reported a study about three candidate genes which may be involved in non-insulin dependent diabetes mellitus (NIDDM): Pyruvate Dehydrogenase Kinase 4 (PDK4), Paraoxonase 2 (PON2) and Fatty Acid Binding Protein 2 (FABP2). The reported mutation in the three candidate genes were tested for 179 black subjects from Dakar (Sénégal) by PCR-RFLP techniques. There was no significant difference between both control and NIDDM subjects. The genotype frequency in the senegalese population was quite similar as compared to reported frequency in white populations excepted for PDK4 polymorphism. These results suggest that none of these gene variants is a major NIDDM predisposing locus for the negroid population of Senegal.
Che
D
D
Service de Biochimie, Fondation Hôpital Saint-Joseph, Rue Raymond Losserand, Paris, France.
Chauffert
M
M
Cisse
A
A
Michel
S
S
Trivin
F
F
D000293:Adolescent; D000328:Adult; D043303:Aryldialkylphosphatase / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000235:genetics*; D006801:Humans; D007223:Infant; D011110:Polymorphism, Genetic; D011494:Protein Kinases / Q000235:genetics*
D002352:Carrier Proteins; C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D011494:Protein Kinases; C403287:pyruvate dehydrogenase kinase 4; D043303:Aryldialkylphosphatase; C468411:PON2 protein, human