Adenovirus type F subtype 41 causing disseminated disease following bone marrow transplantation for immunodeficiency.
Adenovirus causes disseminated disease following bone marrow transplantation (BMT). We report a child who underwent T-cell-depleted BMT. Adenovirus subgenus F serotype 41 was detected antemortem by PCR in cerebrospinal fluid and postmortem in other tissues. Serotypes 40 and 41, associated with gastrointestinal disease, have not previously been implicated in disseminated disease.
Slatter
Mary A
MA
Paediatric Immunology Unit, Ward 23, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom.
Read
Steven
S
Taylor
Clive E
CE
Crooks
Bruce N A
BN
Abinun
Mario
M
Flood
Terence J
TJ
Cant
Andrew J
AJ
Wright
Christopher
C
Gennery
Andrew R
AR
D000258:Adenovirus Infections, Human / Q000209:etiology*; D000260:Adenoviruses, Human / Q000145:classification* / Q000302:isolation & purification; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D016133:Polymerase Chain Reaction; D016511:Severe Combined Immunodeficiency / Q000628:therapy*