title: Influence of kidney function to the impact of acute rejection on long-term kidney transplant survival.
abstract: In kidney transplantation, timing of an initial acute rejection (AR) is correlated with a variable risk of graft loss. However, it is unknown whether the increased risk for graft loss because of AR is conditioned by impaired graft function. A total of 730 cadaveric kidney transplant recipients were retrospectively evaluated from 1994 to 2001. When AR occurred, the risk ratio (RR) for graft loss was strongly time-dependent and increased, the later the rejection episode occurred. Compared with the reference group (no rejection) having an AR within 0-30, 31-365, or >365 days post-transplant conferred a 3.1-, 9.1- and 49.3-fold risk for subsequent graft loss (P < 0.001). By including serum creatinine as an indicator for graft function at the time of rejection RR decreased to 2.4-, 7.1- and 21.8-fold, but remained still significant (P = 0.023). In conclusion, the higher risk of graft loss after late AR is not fully explained by impaired graft function measured by serum creatinine.
authors.affiliation: Division of Organ Transplantation, University of Wisconsin Hospital and Clinics, Madison, USA.
authors.forename: Philipp C
authors.initials: PC
authors.lastname: Nett
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Heisey
authors.forename: Brian D
authors.initials: BD
authors.lastname: Shames
authors.forename: Luis A
authors.initials: LA
authors.lastname: Fernandez
authors.forename: John D
authors.initials: JD
authors.lastname: Pirsch
authors.forename: Hans W
authors.initials: HW
authors.lastname: Sollinger
mesh_terms: D000208:Acute Disease; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D003404:Creatinine