title: Sitostanetriol is not formed in vivo from sitosterol in the rat.
abstract: In a recent study, we observed some oxyphytosterols in the plasma of healthy human subjects. This experiment was effected in order to determine if these compounds could be formed in vivo from phytosterols. Rats were fed with a high level of phytosterols (1% of the diet) and they were compared to rats deprived of phytosterols, using triglycerides purified from phytosterols. Their plasma were analysed for the main oxyphytosterols. The results show that sitostanetriol and campestanetriol were not formed in vivo from phytosterols. Their levels decreased during the experiment. The diet origin is highly probable for the compounds identified in human plasma. In particular, it seems that the sitostanetriol is eliminated very slowly from the organism.
authors.affiliation: INRA, BP 86510, 21065 Dijon Cedex, France. andre.grandgirard@wanadoo.fr
authors.forename: André
authors.initials: A
authors.lastname: Grandgirard
authors.forename: Lucy
authors.initials: L
authors.lastname: Martine
authors.forename: Pierre
authors.initials: P
authors.lastname: Juanéda
authors.forename: Catherine
authors.initials: C
authors.lastname: Cordelet
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D010084:Oxidation-Reduction; D010840:Phytosterols / Q000008:administration & dosage* / Q000378:metabolism* / Q000493:pharmacokinetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012855:Sitosterols / Q000378:metabolism*; D014280:Triglycerides / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D010840:Phytosterols; D012855:Sitosterols; D014280:Triglycerides; C025473:gamma-sitosterol