title: Increased concentrations of lipoprotein(a), circadian rhythms and metabolic reactions evoked by acute myocardial infarction, associated with acute reactions in relation to large breakfasts.
abstract: Of 54 patients with acute coronary artery disease (CAD) that were included in this study, 41 patients had acute myocardial infarction (AMI), five patients possible MI, four patients unstable angina and the remaining four angina pectoris. The control subjects (n = 85) were randomly selected from the general population of the city of Moradabad of similar age range after exclusion for CAD (n = 9), diabetes (n = 6) and excess intake of trans fatty acids (n = 20). The incidence of lipoprotein(a) excess (> 30 mg/dl; 42.6 vs 24.7%; P < 0.05) and mean concentration of lipoprotein(a) (Lp[a], 6.4 mg/dl, 95% confidence interval: 2.8-10.5; P < 0.05) was significantly greater in the acute CAD group compared with control subjects. Mean total cholesterol and triglycerides were significantly higher and mean nitrite level lower in the study group as compared with the control group.There was a significant greater incidence of cardiac events in the second quarter of the day compared with the fourth quarter. Lp(a), triglycerides, blood glucose, plasma insulin, malondialdehyde, diene conjugates, TBARS and TNF-alpha and IL-6 levels, which were significantly greater during the acute phase, showed a significant decline and serum nitrite and coenzyme Q demonstrated an increase at 4 weeks of follow-up when the acute reactions evoked by MI had been controlled. Large breakfasts were a predisposing factor for cardiac events in the second quarter of the day and it was significantly associated with metabolic reactions. The findings indicate that acute reactions as a result or as circadian rhythms appear to be important in the pathogenesis of AMI-associated complications and that a large breakfast in association with nitrite deficiency may further trigger the circadian rhythms. However, more studies in a larger number of subjects would be necessary in order to confirm our findings.
authors.affiliation: Halberg Hospital and Research Institute, Moradabad, India. icn2005@mickyonline.com
authors.forename: Ram B
authors.initials: RB
authors.lastname: Singh
authors.forename: Daniel
authors.initials: D
authors.lastname: Pella
authors.forename: Jagdish P
authors.initials: JP
authors.lastname: Sharma
authors.forename: Saurabh
authors.initials: S
authors.lastname: Rastogi
authors.forename: Kumar
authors.initials: K
authors.lastname: Kartikey
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Goel
authors.forename: Rakesh
authors.initials: R
authors.lastname: Sharma
authors.forename: Narankar S
authors.initials: NS
authors.lastname: Neki
authors.forename: Adarsh
authors.initials: A
authors.lastname: Kumar
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Otsuka
mesh_terms: D000208:Acute Disease; D001711:Biotransformation; D001786:Blood Glucose; D002784:Cholesterol / Q000097:blood; D002940:Circadian Rhythm / Q000502:physiology*; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis; D004032:Diet / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007194:India / Q000208:ethnology; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol