title: Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy.
abstract: Our recent study found that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol composed of multiple 3-min fractionated irradiations with a light emitting diode (LED) red light at 635 +/- 5 nm for a total of 1000 s (fluence rate: 100 mW/cm(2); light exposure dose: 100 J/cm(2)) after topical application of 20% ALA for 1.5 or 2 h can be used successfully for the treatment of oral verrucous hyperplasia. In this case report, we tested the efficacy of this new treatment protocol of ALA-PDT for an extraoral verrucous carcinoma (VC) lesion at the right mouth angle and an intraoral VC lesion at the right buccal mucosa of a 56-year-old male areca quid chewer and smoker. The extraoral tumor was cleared after six treatments of topical ALA-PDT and the intraoral tumor showed complete regression after 22 treatments of topical ALA-PDT. No recurrence of the VC lesion was found after a follow-up period of 6 months. We suggest that PDT using a topical application of 20% ALA followed by multiple 3-min fractionated irradiations with an LED red light is also an effective and successful treatment modality for VC.
authors.affiliation: Department of Dentistry, National Taiwan University Hospital, Taipei 100, Taiwan.
authors.forename: Hsin-Ming
authors.initials: HM
authors.lastname: Chen
authors.forename: Chin-Tin
authors.initials: CT
authors.lastname: Chen
authors.forename: Hsiang
authors.initials: H
authors.lastname: Yang
authors.forename: Ming-I
authors.initials: MI
authors.lastname: Lee
authors.forename: Mark Yen-Ping
authors.initials: MY
authors.lastname: Kuo
authors.forename: Ying-Shiung
authors.initials: YS
authors.lastname: Kuo
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Tsuimin
authors.initials: T
authors.lastname: Tsai
authors.forename: Chun-Pin
authors.initials: CP
authors.lastname: Chiang
mesh_terms: D000287:Administration, Topical; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D018289:Carcinoma, Verrucous / Q000188:drug therapy*; D019583:Dose Fractionation, Radiation; D005500:Follow-Up Studies; D006801:Humans; D008048:Lip Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy / Q000295:instrumentation / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid