Role of hypobaria in fluid balance response to hypoxia.
To estimate the separate and combined effects of reduced P(B) and O2 levels on body fluid balance and regulating hormones, measurements were made during reduced PB (altitude, ALT; P(B) = 432 mm Hg, F(I(O2)) = 0.207), reduced inspired O2 concentration (normobaric hypoxia, HYX; P(B) = 614 mm Hg, F(I(O2)) = 0.142), and lowered ambient pressure without hypoxia (normoxic hypobaria HYB; P(B) = 434 mm Hg, F(I(O2)) = 0.296). Nine fit and healthy young men were exposed to these conditions for 10 h in a decompression chamber. Lake Louise AMS scores, urine collections, and blood samples were obtained every 3 h, with recovery measurements 2 h after exposure. AMS was significantly greater during ALT than HYX, as previously reported (J. Appl. Physiol. 81:1908-1910. 1996), because the combination of reduced P(B) and P(O2) over the 10 h favored fluid retention by reducing urine volume, while plasma volume (PV) remained higher than during HYX. At ALT the plasma Na+ fell significantly at 6 h, probably from dilution of extracellular fluid, and antidiuretic hormone (ADH) was highest (p = 0.006 versus HYB). The PV, urine flow, free water clearance, and plasma renin activity (PRA) rose significantly during recovery from ALT as AMS symptoms subsided, suggesting increased intravascular fluid and reduced adrenergic tone. During HYB, the plasma aldosterone (ALDO) and K+ levels were significantly elevated, and PRA was highest and ADH lowest, without fluid retention. During HYX, fluid balance was similar to HYB, but PV and ALDO were significantly lower, and ALDO increased significantly in recovery from HYX. The fluid retention at ALT in AMS-susceptible subjects appears related to a synergistic interaction involving reduced P(B) and ADH and ALDO.
Loeppky
Jack A
JA
Cardiology Section, VA Medical Center, Albuquerque, New Mexico. loeppky@unm.edu
Roach
Robert C
RC
Maes
Damon
D
Hinghofer-Szalkay
Helmut
H
Roessler
Andreas
A
Gates
Lee
L
Fletcher
E Royce
ER
Icenogle
Milton V
MV
D000064:Acclimatization; D000208:Acute Disease; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000531:Altitude; D000532:Altitude Sickness / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D000704:Analysis of Variance; D001127:Arginine Vasopressin / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D001826:Body Fluids; D006801:Humans; D008297:Male; D009516:New Mexico; D009638:Norepinephrine / Q000097:blood; D012083:Renin / Q000097:blood; D014882:Water-Electrolyte Balance; D014883:Water-Electrolyte Imbalance
D001127:Arginine Vasopressin; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin; D009638:Norepinephrine