Pharmacology of Alzheimer's disease: appraisal and prospects.
Ten years after the introduction of the first drug, tacrine, in the treatment of Alzheimer's disease, it seems appropriate to re-appraise the pharmacological processes of innovation in the research field of dementia. The aim of this review is to pinpoint concrete improvements achieved in this field, regarding experimental methods and clinical evaluation of the compounds, as well as the neurochemistry of the disease and cellular targets to consider in priority. This review deals with this objective in three parts: (1) assessment of current therapeutics, (2) discussion of the experimental models and clinical practices and (3) prospective drugs of the future. The implementation of considered strategies will require the involvement and close cooperation between political decisions, pharmaceutical companies and the scientific community.
Sellal
François
F
Hôpital Universitaire, Strasbourg, France.
Nieoullon
André
A
Michel
Géraldine
G
Michel
Bernard François
BF
Lacomblez
Lucette
L
Geerts
Hugo
H
Delini Stula
Alexandra
A
Bordet
Régis
R
Bentué-Ferrer
Danièle
D
Allain
Hervé
H
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D018697:Nootropic Agents / Q000627:therapeutic use*
D018697:Nootropic Agents