[Successful treatment with etoposide by oral administration for recurrence of gastric diffuse large B-cell lymphoma after surgical resection--a case report].
A 64-year-old woman, who had been treated for gastric diffuse large B-cell lymphoma (DLBCL) by total gastrectomy and received 3 courses of CHOP therapy at 61 years of age, was diagnosed with recurrence of DLBCL in the small intestine. After the small intestinal tumor was resected, multiple metastases were found in the liver. Because intensive chemotherapy was difficult for her poor performance status, 50 mg of etoposide daily by oral was administered for 21 consecutive days. After one course of chemotherapy, liver metastases and lymph node swelling almost disappeared without severe adverse effects, and after five courses she achieved complete remission. Though DLBCL invaded the central nervous system, the abdominal regions had been free from recurrence for 12 months. This case report suggests that oral etoposide therapy is useful for gastrointestinal DLBCL which has metastasized to the liver.
Fukushima
Toshihiro
T
Division of Hematology and Immunology, Kanazawa Medical University.
Sawaki
Toshioki
T
Shimoyama
Kumiko
K
Karasawa
Hiromi
H
Masaki
Yasufumi
Y
Kawabata
Hiroshi
H
Ogawa
Noriyoshi
N
Wano
Yuji
Y
Hirose
Yuko
Y
Sugai
Susumu
S
Sutoh
Hidemasa
H
Itoh
Hiroshi
H
Kojima
Yasuhiko
Y
D000284:Administration, Oral; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007078:Ileal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008113:Liver Neoplasms / Q000556:secondary; D016393:Lymphoma, B-Cell / Q000188:drug therapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy*; D008875:Middle Aged; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery
D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide