title: [Relationship of plasma nitric oxide concentration and the activity of nitric oxide synthase with coronary heart disease].
abstract: OBJECTIVE
  To study the levels of nitric oxide synthase (NOS) and nitric oxide (NO) in patients with coronary heart disease (CHD), and the factors affecting them.
  
  
  METHODS
  Concentrations of NO and the activities of NOS in plasma in 136 patients and 206 controls using the corresponding Kits were measured. The data were analyzed using covariance and multiple linear regression analysis with SAS 8.1.
  
  
  RESULTS
  The levels of NO [(217.05 +/- 153.31) micromol/L] and NOS [(14.09 +/- 7.14) U/ml] in patients were significantly higher than that in the healthy controls [(140.69 +/- 90.96) micromol/L, (7.75 +/- 3.79) U/ml, respectively, P < 0.01]. Smoking and drinking were the independent risk factors for NOS, while sex was the independent risk factor for NO (P < 0.01).
  
  
  CONCLUSIONS
  The levels of plasma NO and NOS are closely related with coronary heart disease.
authors.affiliation: Institute of Occupational Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Gao
authors.forename: Mei-An
authors.initials: MA
authors.lastname: He
authors.forename: Chang-Zheng
authors.initials: CZ
authors.lastname: Jiang
authors.forename: Miao
authors.initials: M
authors.lastname: Yang
authors.forename: Li-Yun
authors.initials: LY
authors.lastname: Zhang
authors.forename: Tang-Chun
authors.initials: TC
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009569:Nitric Oxide / Q000097:blood*; D019001:Nitric Oxide Synthase / Q000097:blood*; D010949:Plasma / Q000378:metabolism
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase