Gammadelta T cell development--having the strength to get there.
Gammadelta T cells play critical roles in immune regulation, tumour surveillance and specific primary immune responses. Mature gammadelta cells derive from thymic precursors that also generate alphabeta T cells. Recent reports have highlighted the impact of the strength of signal received via the T cell receptor on T cell lineage commitment, and the importance of cross-talk between committed alphabeta thymocytes and bipotential progenitors for normal gammadelta T cell differentiation. Studies on T cell receptor-mediated selection of gammadelta cells have supported the view that these unconventional T cells are positively rather than negatively selected on cognate self antigen.
Pennington
Daniel J
DJ
Peter Gorer Department of Immunobiology, Guy's King's St. Thomas' Medical School, King's College, Guy's Hospital, London SE1 9RT, UK. Daniel.Pennington@kcl.ac.uk
Silva-Santos
Bruno
B
Hayday
Adrian C
AC
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology* / Q000502:physiology; D017637:Clonal Deletion / Q000276:immunology / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology / Q000502:physiology
D008565:Membrane Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta; D051880:Receptors, Notch