[Pharmaceutical agents for calcium-induced cell damage (T-type calcium channel antagonist)].
T-type Ca(2+) channels have properties distinct from the L-type and are involved in cardiac pacemaking and blood flow. Novel drugs with action on both L-type and T-type Ca(2+) channels, such as efonidipine, has been shown to optimize blood pressure and heart rate with minimum effect on myocardial contraction. Further studies on their organ-protective effects are now in progress.
Tanaka
H
H
Department of Pharmacology, Toho University School of Pharmaceutical Sciences.
Shigenobu
K
K