SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption.
Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.
McCormick
James A
JA
Department of Medicine, University of California-San Francisco, San Francisco, California, USA.
Bhalla
Vivek
V
Pao
Alan C
AC
Pearce
David
D
D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D053503:Epithelial Sodium Channels; D006801:Humans; D017874:Immediate-Early Proteins; D007668:Kidney / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels / Q000378:metabolism; D000099184:Serum-Glucocorticoid Regulated Kinases
D000450:Aldosterone; D053503:Epithelial Sodium Channels; D017874:Immediate-Early Proteins; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; D012964:Sodium; D015222:Sodium Channels; D000099184:Serum-Glucocorticoid Regulated Kinases