[Determination of arsenic in As2O3-treated esophagoscope-transplant mouse tissue by graphite furnace atomic absorption spectrometry].
As2O3 was injected into tumour tissue of esophagoscope-transplant mouse. The concentration of As diffusing into other tissues was investigated. A method was proposed for the determination of As in tissue samples of mouse by graphite furnace atomic absorption spectrometry. After wet digestion (water-bath at 80 degrees C) with 2:1:1 (psi) of HNO3-H2SO4-HClO4, the digested tissue samples of mouse were diluted with 0.2% Triton X-100-0.4% AgNO3. The matrix-matching calibration curve of non-interference was established with standard addition method. The relative standard deviation was 3.2%-8.7%. The limit of detection was 1.57 microg x L(-1). The recoveries were 81.7%-105% Arsenic concentrations in mouse liver, kidney, brain, left-chest, and right-chest were determined after injection of arsenic at different times.
Zhang
Yuan
Y
Central Laboratories, Shantou University Medical College, Shantou 515031, China.
Luo
Wen-hong
WH
Li
Hui
H
Shen
Zhong-ying
ZY
D000821:Animal Feed / Q000032:analysis; D000818:Animals; D001151:Arsenic / Q000032:analysis / Q000494:pharmacology*; D000077237:Arsenic Trioxide; D001152:Arsenicals; D006108:Graphite / Q000737:chemistry; D051379:Mice; D010087:Oxides / Q000633:toxicity*; D016491:Peripheral Vascular Diseases / Q000139:chemically induced; D013054:Spectrophotometry, Atomic / Q000379:methods*
D001152:Arsenicals; D010087:Oxides; D006108:Graphite; D001151:Arsenic; D000077237:Arsenic Trioxide