title: Structure-based systems biology: a zoom lens for the cell.
abstract: Systems biology seeks to explain complex biological systems, such as the cell, through the integration of many different types of information. Here, we discuss how the incorporation of high-resolution structural data can provide key molecular details often necessary to understand the complex connection between individual molecules and cell behavior. We suggest a process of zooming on the cell, from global networks through pathways to the precise atomic contacts at the interfaces of interacting proteins.
authors.affiliation: EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. aloy@embl.de
authors.forename: Patrick
authors.initials: P
authors.lastname: Aloy
authors.forename: Robert B
authors.initials: RB
authors.lastname: Russell
mesh_terms: D000818:Animals; D019295:Computational Biology; D003198:Computer Simulation; D030562:Databases, Protein; D006801:Humans; D007700:Kinetics; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry* / Q000502:physiology
chemical_list: D011506:Proteins