title: [Exanthematous diseases and the first epidemic of dengue to occur in Manaus, Amazonas State, Brazil, during 1998-1999].
abstract: In 1998, the FMT/IMT-AM foundation implemented the surveillance system to diagnose acute undifferentiated febrile syndromes, with the objective of active and passive surveillance in Brazilian western Amazonian rainforest to identify and diagnose the etiologic agents of acute fever. The diagnoses were performed using serological tests to detect IgM antibodies by ELISA (Enzyme-linked-immunosorbent assay) CDC/OPAS or using commercial kits. A total of 8,557 serum samples obtained from patients with clinical suspicion of dengue virus were analyzed. ELISA positive reaction to dengue virus was presented by 40% of the serum samples and 26% of the serum samples had positive ELISA reactions to other exanthematous viral diseases, such as rubella, measles, parvovirus, Oropouche virus and Mayaro virus.
authors.affiliation: Fundação de Medicina Tropical do Instituto de Medicina Tropical do Amazonas, Manaus, AM. regina68@ig.com.br
authors.forename: Regina Maria Pinto
authors.initials: RM
authors.lastname: De Figueiredo
authors.forename: Bedsy Dutary
authors.initials: BD
authors.lastname: Thatcher
authors.forename: Mário Lira
authors.initials: ML
authors.lastname: de Lima
authors.forename: Tânia Carvalho
authors.initials: TC
authors.lastname: Almeida
authors.forename: Wilson Duarte
authors.initials: WD
authors.lastname: Alecrim
authors.forename: Marcus Vinitius de Farias
authors.initials: MV
authors.lastname: Guerra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology*; D003716:Dengue Virus / Q000276:immunology; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D005076:Exanthema / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012621:Seasons
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M