Comparison of in vitro susceptibilities of ocular bacterial isolates to gatifloxacin and other topical antibiotics.
OBJECTIVE
To compare the in vitro activity of gatifloxacin with that of other topical antibiotics against fresh bacterial isolates from various types of human ocular infections.


METHODS
A total of 498 strains of ocular bacterial isolates were tested for their susceptibility to gatifloxacin, ofloxacin, ciprofloxacin, norfloxacin, gentamicin, tobramycin, neomycin, chloramphenicol, erythromycin, tetracycline and amikacin.


RESULTS
Ninety-nine percent of gram-positive and 92% of gram-negative bacterial strains were found to be susceptible in vitro to gatifloxacin, whereas lower percentages of gram-positive and gram-negative bacteria were found to be susceptible to other antibiotics.


CONCLUSIONS
In vitro, gatifloxacin exhibits good activity against various bacterial species isolated from different ocular sites. This requires corroboration in the clinical setting.
Kaliamurthy
J
J
Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, India.
Nelson Jesudasan
C A
CA
Geraldine
P
P
Parmar
P
P
Kalavathy
C M
CM
Thomas
P A
PA
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D015818:Eye Infections, Bacterial / Q000382:microbiology; D024841:Fluoroquinolones / Q000494:pharmacology*; D000077734:Gatifloxacin; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D009883:Ophthalmic Solutions / Q000494:pharmacology
D000891:Anti-Infective Agents, Local; D024841:Fluoroquinolones; D009883:Ophthalmic Solutions; D000077734:Gatifloxacin