Kinetics of engraftment following allogeneic hematopoietic cell transplantation with reduced-intensity or nonmyeloablative conditioning.
Nonmyeloablative or reduced-intensity conditioning regimens have been used to condition elderly or ill patients with hematological malignancies for allogeneic hematopoietic cell transplantation (HCT). Initial mixed donor/host chimerism (i.e. the coexistence of hematopoietic cells of host and donor origin) has been observed in most patients after such transplants. Here, we describe both factors affecting engraftment kinetics in patients given a nonmyeloablative or a reduced-intensity conditioning, and associations between peripheral blood cell subset chimerism levels and HCT outcomes.
Baron
Frédéric
F
Clinical Research Division, Fred Hutchinson Cancer Research Center, P.O. Box 19024, Seattle, WA, USA. fbaron@fhcrc.org
Little
Marie-Térèse
MT
Storb
Rainer
R
D006085:Graft Survival; D006086:Graft vs Host Disease; D006801:Humans; D033581:Stem Cell Transplantation; D019172:Transplantation Conditioning