Genetics of subthalamic nucleus in development and disease.
The subthalamic nucleus (STN) is a crucial node in the basal ganglia. Clinical success in targeting the STN for deep brain stimulation in Parkinson's disease patients has prompted increased interest in understanding STN biology. In this report, we discuss recent evidence for transcription factor mediated regulation of STN development. We also review STN developmental neurobiology and known patterns of gene expression in the developing and mature STN.
Philips
Steven T
ST
Department of Pediatrics, The University of Michigan, Ann Arbor, MI 48109, USA.
Albin
Roger L
RL
Martin
Donna M
DM
D000818:Animals; D001927:Brain Diseases / Q000378:metabolism; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D016571:Neural Networks, Computer; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009474:Neurons / Q000502:physiology; D020531:Subthalamic Nucleus / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D014157:Transcription Factors