title: Macro-structural effect of metal surfaces treated using computer-assisted yttrium-aluminum-garnet laser scanning on bone-implant fixation.
abstract: Porous coatings have been applied to the surface of prosthetic devices to foster stable device fixation. The coating serves as a source of mechanical interlocking and may stimulate healthy bone growth through osseointegrated load transfer in cementless arthroplasty. Joint arthroplasty by porous-coated prostheses is one of the most common surgical treatments, and has provided painless and successful joint mobility. However, long-term success is often impaired by the loss of fixation between the prosthesis and bone. Porous-coated prostheses are associated with several disadvantages, including metal debris from porous coatings (third body wear particles) and irregular micro-texture of metal surfaces. Consequently, quantitative histological analysis has been very difficult. These issues arise because the porous coating treatment is based on addition of material and is not precisely controllable. We recently developed a precisely controllable porous texture technique based on material removal by yttrium-aluminum-garnet laser. Free shapes can be applied to complex, three-dimensional hard metal surfaces using this technique. In this study, tartan check shapes made by crossing grooves and dot shapes made by forming holes were produced on titanium (Ti6A14V) or cobalt chrome (CoCr) and evaluated with computer-assisted histological analysis and measurement of bone-metal interface shear strength. Width of grooves or holes ranged from 100 to 800 mum (100, 200, 500, and 800 microm), with a depth of 500 microm. When the cylindrical porous-texture-treated metal samples (diameter, 5 mm; height, 15 mm) were implanted into a rabbit femoral condyle, bone tissue with bone trabeculae formed in the grooves and holes after 2 or 4 weeks, especially in 500-microm-wide grooves. Abundant osteoconduction was consistently observed throughout 500-microm-wide grooves in both Ti6A14V and CoCr. Speed of osteoconduction was faster in Ti6A14V than in CoCr, especially in the tartan check shape made of 500-microm-wide grooves. In pushout testing, the tartan check shape made of 500-microm-wide grooves had significantly higher bone-metal interface shear strength than the dot shape or commercial porous coating. These results indicate that the tartan check shape made of 500-microm-wide grooves on metal surfaces has potential for clinical application in artificial prosthesis design.
authors.affiliation: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 5650871 Yamadaoka 2-2, Suita City, Osaka, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirao
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Sugamoto
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Tamai
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Oka
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Mori
authors.forename: Takatomo
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000535:Aluminum; D000818:Animals; D018786:Bone Substitutes; D007091:Image Processing, Computer-Assisted; D008422:Materials Testing; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D011817:Rabbits; D015019:Yttrium
chemical_list: D018786:Bone Substitutes; D015019:Yttrium; D000535:Aluminum