[Evaluation of the efficacy of azithromycin and pyrimethamine, for treatment of experimental infection of mice with Toxoplasma gondii cystogenic strain].
The efficacy of prolonged administration of azithromycin and pyrimethamine was evaluated in mice experimentally infected with cystogenic strain of Toxoplasma gondii. The animals were intraperitoneally inoculated with one cyst of T. gondii and after 20 days were allocated into four groups: GI, infected without treatment; GII, infected and treated with the association of pyrimethamine (12.5 mg/kg/day) and azithromycin (100 mg/kg/day); GIII, infected and treated with the same dose of pyrimethamine; and GIV, infected and treated in the same way with azithromycin. The oral treatment lasted 120 days, after this period all the animals were sacrificed and the count of cysts in the brain was done. The association of both drugs provided the best results, by diminishing the cyst count in the brain of the animals treated in this way.
Lescano
Susana A Z
SA
Laboratório de Imunopatologia da Esquistossomose (LIM 06) da Universidade de São Paulo, São Paulo, SP. chiong@uol.com.br
Amato Neto
Vicente
V
Chieffi
Pedro P
PP
Bezerra
Rita C
RC
Gakiya
Erika
E
Ferreira
Cláudio Santos
CS
Braz
Lúcia M A
LM
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011739:Pyrimethamine / Q000627:therapeutic use*; D014122:Toxoplasma / Q000187:drug effects / Q000302:isolation & purification*; D014124:Toxoplasmosis, Animal / Q000188:drug therapy*
D000981:Antiprotozoal Agents; D017963:Azithromycin; D011739:Pyrimethamine