Bilateral increase of perforated synapses after unilateral dopamine depletion.
In recent years attention has been focused on perforated synapses considering their possible involvement in synaptic plasticity in the nervous system. It has been hypothesized that an increase in the number of synapses may represent a structural basis for the enduring expression of synaptic plasticity during some events that involve memory and learning; also it has been suggested that perforated synapses increase in number after some experimental situations. The aim of this study was to analyze whether the dopamine depletion produces changes in the synaptology of the corpus striatum of rats after the unilateral injection of 6-OHDA. The findings suggest that after the lesion, both contralateral and ipsilateral striata present a significant increment in the number of perforated synapses, suggesting brain plasticity that might be an intent to recuperate the contact surface lost after endogenous or exogenous aggressions.
Avila-Costa
María Rosa
MR
Department of Neuroscience, National University of Mexico, Iztacala, Mexico. nigraizo@servidor.unam.mx
Colín-Barenque
Laura
L
Aley-Medina
Patricia
P
Valdez
Ana Luisa Gutiérrez
AL
Librado
José Luis Ordoñes
JL
Martinez
Erick Flores
EF
Fortoul
Teresa I
TI
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000172:deficiency* / Q000502:physiology; D018491:Dopamine Agonists / Q000494:pharmacology; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology*; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D016627:Oxidopamine / Q000633:toxicity; D017729:Presynaptic Terminals / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology; D013565:Sympatholytics / Q000633:toxicity; D013569:Synapses / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure
D018491:Dopamine Agonists; D013565:Sympatholytics; D016627:Oxidopamine; D001058:Apomorphine; D004298:Dopamine