Quantitative analysis of beta-blockers in pharmaceutical preparations by capillary electrophoresis.
A simple capillary electrophoresis method was developed for the analysis of four beta-blockers (atenolol, metoprolol, pindolol, and propranolol) in pharmaceutical preparations. The method was validated regarding accuracy, precision, linearity, and detection/quantification limits, and the obtained values were in accordance to those reported in the literature. The method was applied to the determination of the drugs in commercial tablet preparations and proved to be fast and reliable for the quantitative analysis of the beta-blockers.
Coragem Briguenti
Ana Cecília
AC
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP 14040-903, Brazil.
Bonato
Pierina Sueli
PS
D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D019075:Electrophoresis, Capillary; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013607:Tablets / Q000032:analysis
D000319:Adrenergic beta-Antagonists; D004364:Pharmaceutical Preparations; D013607:Tablets