title: [Adsorption of substances on active charcoal. Part 2: basic esters of phenylcarbamic acid with beta-adrenolytic effect].
abstract: The paper is concerned with the study of adsorption on active charcoal in a set of selected substances from the group of aryloxyaminopropanol derivatives with carbamate substitution on the benzene ring with beta-adrenolytic effect (Group A) and a set of substances, derivatives of [(arylcarbonyl)oxylaminopropanol with the identical, but assumed ultra-short effect (Group B), where the effect was produced by replacing the phenolether group with a metabolically unstable ester functional group. The course of adsorption in buffer solution with pH 7 in dependence on time and concentration is examined. Adsorptivity of substances is evaluated according to Freundlich and Langmuir models. Affinity of substances of Group A to adsorption material decreases with increasing hydrophilicity.
authors.affiliation: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava. stankovicm@fpharm.uniba.sk
authors.forename: M
authors.initials: M
authors.lastname: Stankovicová
authors.forename: Z
authors.initials: Z
authors.lastname: Zlevská
authors.forename: Z
authors.initials: Z
authors.lastname: Bezáková
authors.forename: P
authors.initials: P
authors.lastname: Mokrý
authors.forename: J
authors.initials: J
authors.lastname: Csöllei
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D000327:Adsorption; D002606:Charcoal; D048448:Phenylcarbamates / Q000737:chemistry*
chemical_list: D000319:Adrenergic beta-Antagonists; D048448:Phenylcarbamates; D002606:Charcoal