Sensorimotor dysfunction in HIV/AIDS: effects of antiretroviral treatment and comorbid psychiatric disorders.
OBJECTIVE
Balance and gait problems have repeatedly been mentioned in case descriptions of patients infected with Human Immunodeficiency Virus (HIV-1). Objective evidence of these problems has rarely been reported, however. Furthermore, the extent to which balance and gait are influenced by antiretroviral medications or comorbid psychiatric disorders has rarely been examined.


METHODS
The study compared 78 HIV-1 seronegative volunteers to 28 HIV/AIDS patients receiving no antiretroviral therapy, 25 patients receiving only nucleoside analogue therapy, and 37 patients receiving Highly Active Antiretroviral Therapy (HAART).


METHODS
The dependent measures included Equilibrium Quotient scores recorded during 3 subtests of the Sensory Organization Test (SOT), the number of falls during each subtest, the functional base of support, gait speed and cadence, single leg balance time, proximal strength, and vibrotactile threshold of the foot. The analysis employed the number of alcohol and drug abuse problems, depression severity, and body mass index as covariates.


RESULTS
ANCOVAs revealed significant decrements in the 3 HIV-1 seropositive groups relative to the control group on Equilibrium Quotient scores during the most difficult of the SOT subtests (sway-referenced support surface with eyes-closed). HIV/AIDS patients also exhibited a smaller functional base of support and greater vibrotactile thresholds. Antiretroviral treatment did not affect balance; but, it did alter sensory threshold in a complex manner.


CONCLUSIONS
HIV/AIDS is associated with reliable decrements in balance and peripheral sensory function which are variably sensitive to antiretroviral treatment. The implications of these findings for mobility, and workplace or operator safety, should be contemplated.
Bauer
Lance O
LO
Departments of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030-2103, USA. bauer@psychiatry.uchc.edu
Ceballos
Natalie A
NA
Shanley
John D
JD
Wolfson
Leslie I
LI
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D000328:Adult; D000704:Analysis of Variance; D044966:Anti-Retroviral Agents / Q000009:adverse effects*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects / Q000379:methods; D003865:Major Depressive Disorder / Q000150:complications / Q000503:physiopathology; D005260:Female; D005684:Gait / Q000187:drug effects / Q000502:physiology; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D015497:HIV-1; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications* / Q000503:physiopathology; D009483:Neuropsychological Tests; D004856:Postural Balance / Q000187:drug effects / Q000502:physiology; D011596:Psychomotor Disorders / Q000150:complications* / Q000503:physiopathology; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D019966:Substance-Related Disorders / Q000150:complications / Q000503:physiopathology
D044966:Anti-Retroviral Agents