[Fibrinolysis parameters: plasmin-alpha2 antiplasmin complexes (PAP) and D-dimers in acute coronary syndromes without ST segment elevation].
The aim of the paper was to determine concentrations of plasmin-alpha2 antiplasmin complexes (PAP) and D-dimers in blood of patients suffering from acute coronary syndromes without ST segment elevation. 78 patients, including 37 females and 41 males, aged 41-79 years (mean age 63.2) were included in the study. Concentrations of PAP were determined by immmunoenzymatic method using Enzygnost PAP micro kit and concentrations of D-dimers using Dade Berling Enzygnost D-Dimer micro kit. Statistically significant, higher concentrations of PAP and D-dimers, indicating increased fibrinolytic activity of blood, were observed in patients with acute coronary syndrome than in the control group. Significantly higher concentrations of D-dimers were found in the group of patients above the age of 50, when compared with younger patients. Lower D-dimers levels were observed in smokers. Gender, coexisting hypercholesterolaemia, arterial hypertension and diabetes had no impact on concentrations of PAP and D-dimers in blood of patients suffering from acute coronary syndrome without ST segment elevation.
Grabarczyk
Ewa
E
Zakład Patofizjologii Akademii Medycznej w Bydgoszczy.
Wodyńska
Teresa
T
Kotschy
Maria
M
D000208:Acute Disease; D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism*; D005343:Fibrinolytic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D000979:alpha-2-Antiplasmin / Q000378:metabolism*
D005338:Fibrin Fibrinogen Degradation Products; D005343:Fibrinolytic Agents; D000979:alpha-2-Antiplasmin; C036309:fibrin fragment D; C037742:plasmin-plasmin inhibitor complex; D005341:Fibrinolysin