Physical inactivity is an important lifestyle determinant of insulin resistance in hypertensive patients.
The purpose of the study is to assess the relative impact of lifestyle factors including physical inactivity, cigarette smoking, and alcohol intake on insulin resistance in hypertensive patients. In total, 872 hypertensive patients, of Chinese and Japanese origin, from the Stanford Asia and Pacific Program for Hypertension and Insulin Resistance were included for the current analysis. Homeostasis model assessment for insulin resistance (HOMA-IR) and the insulin sensitivity index ISI0,120 were chosen as surrogate measures of insulin resistance. Standardized interview-administered questionnaires were used to obtain information on demographic and lifestyle characteristics. The sedentary hypertensive patients were more insulin resistant than the non-sedentary hypertensive. There were significant differences in Log (HOMA-IR) (0.06-unit increases, p < 0.01) and Log (ISI0,120) (0.05-unit decreases, p < 0.01) between sedentary and non-sedentary hypertensive patients after controlling demographic variables. There were no differences in insulin sensitivity in subjects with different smoking status. Neither smoking nor alcohol intake was persistently associated with insulin resistance in the analysis. Our results suggest that physical inactivity is an important lifestyle determinant of insulin resistance in hypertensive patients. The influences of smoking and alcohol intake on insulin resistance are less significant than physical inactivity in hypertensive subjects.
Hwu
Chii-Min
CM
Department of Medicine, Taipei Veterans General Hospital, Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan. chhwu@vghtpe.gov.tw
Hsiao
Chin-Fu
CF
Kuo
Shi-Wen
SW
Wu
Kwan-Dun
KD
Ting
Chih-Tai
CT
Quertermous
Thomas
T
Rodriguez
Beatriz
B
Chen
Ida
I
Grove
John
J
Chen
Pao-Yang
PY
Hoo
Low-Tone
LT
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects; D001213:Asian; D002681:China / Q000208:ethnology; D015444:Exercise; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology / Q000208:ethnology; D007333:Insulin Resistance / Q000208:ethnology; D007564:Japan / Q000208:ethnology; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects; D011795:Surveys and Questionnaires; D013624:Taiwan / Q000453:epidemiology; D014481:United States / Q000453:epidemiology / Q000208:ethnology