Adipose tissue is a regulated source of interleukin-10.
White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra. We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase).
Juge-Aubry
Cristiana E
CE
Laboratory of Molecular Endocrinology, Department of Medicine, Geneva Medical School, rue Michel Servet 1, CH-1211 Geneva 4, Switzerland.
Somm
Emmanuel
E
Pernin
Agnès
A
Alizadeh
Navid
N
Giusti
Vittorio
V
Dayer
Jean-Michel
JM
Meier
Christoph A
CA
D000273:Adipose Tissue / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000235:genetics / Q000276:immunology*; D012333:RNA, Messenger / Q000096:biosynthesis
D012333:RNA, Messenger; D016753:Interleukin-10