title: Desflurane and sevoflurane in elderly patients during general anesthesia: a double blind comparison.
abstract: OBJECTIVE
  To investigate pulmonary wash-out of sevoflurane and desflurane and the quality of recovery from anesthesia in elderly patients.
  
  
  METHODS
  Thirty-six patients aged >65 years, ASA II, were assigned in a double blind fashion to either desflurane (n=18) or sevoflurane (n=18) anesthesia. All received propofol 2 mg/kg and remifentanil 0.2 microg/kg/min for induction and 0.6 mg/kg of rocuronium. When the trachea was intubated volatile anaesthetic was administered. All data were recorded 1, 3, 5, 15, 30 min after intubation and then every 15 min. All data were recorded 1, 2, 3, 4, 5 min after suspension of all agents. Once extubated simple orders and questions were given every minute, times of appropriate response were noted. The patients were then transferred to the recovery room, until discharge to the floor. Postoperative pain control was obtained by a continuous iv infusion of ketorolac 60 mg and tramadol 100 mg. The latter was incremented by supplemental boluses of 50 mg according to patient needs (VAS <4) up to a maximum of 300 mg/24h.
  
  
  RESULTS
  The F(A)/F(A0) ratio was lower in the desflurane group after halogenated agent suspension (p= or <0.05). Desflurane proved to have a faster wash out curve with respect to sevoflurane. Early recovery, as indicated by the time necessary to appropriately answer simple questions after the discontinuation of anesthetics, showed a significant advantage for desflurane (p= or <0.05). VAS was higher in the desflurane group as well as the needs for postoperative analgesia.
  
  
  CONCLUSIONS
  Patients receiving desflurane reported faster recovery from anesthesia but an earlier and more intense perception of pain after surgery.
authors.affiliation: Department of Anesthesiological Surgical and Emergency Sciences, Second University of Naples, Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Iannuzzi
authors.forename: M
authors.initials: M
authors.lastname: Iannuzzi
authors.forename: G
authors.initials: G
authors.lastname: Viola
authors.forename: A
authors.initials: A
authors.lastname: Cerulli
authors.forename: V
authors.initials: V
authors.lastname: Cirillo
authors.forename: M
authors.initials: M
authors.lastname: Chiefari
mesh_terms: D000368:Aged; D000768:Anesthesia, General / Q000009:adverse effects; D018685:Anesthetics, Inhalation / Q000009:adverse effects; D000077335:Desflurane; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane