title: Does fibrin sealant decrease immediate urinary leakage following radical retropubic prostatectomy?
abstract: OBJECTIVE
  We determined the effectiveness of fibrin sealant in decreasing postoperative urinary leakage following radical retropubic prostatectomy performed by 1 surgeon at Washington Hospital Center.
  
  
  METHODS
  Between April and November 2003 our group treated 32 consecutive patients with prostate cancer with radical retropubic prostatectomy. The first 16 patients (control) underwent the Walsh described technique and the second group of 16 patients had an additional application of fibrin sealant around the urethro vesical anastomosis. Postoperative drain output was measured every 8 hours. The results of the 2 groups were compared.
  
  
  RESULTS
  The Blake drain was removed after 4 nursing shifts (times 1 through 4) in 81% (13 of 16) of the control group and in 100% (16 of 16) of the fibrin sealant group. The fibrin sealant group had significantly less drainage output overall compared with the control group (p = 0.005). The drainage output from each group decreased with time at a significant rate independent of each other (p <0.001), and there was a larger difference (p = 0.04) in output between groups at times 1 and 2 compared with times 3 and 4. There was no relationship between the amount of urinary drainage and drain output. There was no immediate morbidity associated with the use of fibrin sealant.
  
  
  CONCLUSIONS
  The application of fibrin sealant to the urethro vesical anastomosis during radical retropubic prostatectomy does decrease postoperative drain output. With earlier drain removal, patients would benefit from less discomfort and from skilled nursing requirements. In select patients early drain removal could accelerate discharge home.
authors.affiliation: Department of Urology, Washington Hospital Center, Washington, DC 20010, USA. ericdiner@hotmail.com
authors.forename: Eric K
authors.initials: EK
authors.lastname: Diner
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Patel
authors.forename: Arnold M
authors.initials: AM
authors.lastname: Kwart
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical; D016022:Case-Control Studies; D020878:Device Removal / Q000451:nursing; D004322:Drainage / Q000295:instrumentation; D005122:Exudates and Transudates; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000451:nursing; D011468:Prostatectomy / Q000379:methods* / Q000451:nursing; D011471:Prostatic Neoplasms / Q000601:surgery; D013536:Suture Techniques; D013997:Time Factors; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014521:Urethra / Q000601:surgery; D001743:Urinary Bladder / Q000601:surgery
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives