[Influences of environmental factors and interaction of several chemokines gene-environmental on systemic lupus erythematosus].
OBJECTIVE
To explore the impact of environmental factors, daily lifestyle, psycho-social factors and the interactions between environmental factors and chemokines genes on systemic lupus erythematosus (SLE).


METHODS
Case-control study was carried out and environmental factors for SLE were analyzed by univariate and multivariate unconditional logistic regression. Interactions between environmental factors and chemokines polymorphism contributing to systemic lupus erythematosus were also analyzed by logistic regression model.


RESULTS
There were nineteen factors associated with SLE when univariate unconditional logistic regression was used. However, when multivariate unconditional logistic regression was used, only five factors showed having impacts on the disease, in which drinking well water (OR=0.099) was protective factor for SLE, and multiple drug allergy (OR=8.174), over-exposure to sunshine (OR=18.339), taking antibiotics (OR=9.630) and oral contraceptives were risk factors for SLE. When unconditional logistic regression model was used, results showed that there was interaction between eating irritable food and -2518MCP-1G/G genotype (OR=4.387). No interaction between environmental factors was found that contributing to SLE in this study.


CONCLUSIONS
Many environmental factors were related to SLE, and there was an interaction between -2518MCP-1G/G genotype and eating irritable food.
Ye
Dong-qing
DQ
School of Public Health, Anhui Medical Univercity, Hefei 230032, China. cjdcp@mail.hf.ah.cn
Hu
Yi-song
YS
Li
Xiang-pei
XP
Huang
Fen
F
Yang
Shi-gui
SG
Hao
Jia-hu
JH
Yin
Jing
J
Zhang
Guo-qing
GQ
Liu
Hui-hui
HH
D000328:Adult; D016022:Case-Control Studies; D018925:Chemokines / Q000096:biosynthesis* / Q000235:genetics; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology* / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors; D011795:Surveys and Questionnaires
D018925:Chemokines