title: [Vascular endothelial growth factor expression in focal cerebral ischemia/reperfusion in injury in rats].
abstract: OBJECTIVE
  To study the vascular endothelial growth factor (VEGF) expression and its role in focal cerebral ischemia/reperfusion injury.
  
  
  METHODS
  VEGF protein and mRNA expressions at the site of focal ischemia/reperfusion of rat cerebrum were assessed with immunohistochemistry and hybridization techniques.
  
  
  RESULTS
  In normal cerebral tissue there was lower expression of VEGF. It was found to be expressed in the penumbra area after ischemia. With the prolongation of ischemia and ischemia/reperfusion, enhanced expression of VEGF tended to decline to normal level, while it enhanced in the penumbra area.
  
  
  CONCLUSIONS
  Enhanced VEGF expression might play a protective role in focal ischemia/reperfusion injury to the cerebrum.
authors.affiliation: Department of Neurology, China - Japan Union Hospital, Jilin University, Changchun, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xing
authors.forename: Zhong-xin
authors.initials: ZX
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Mang
authors.forename: Jia-li
authors.initials: JL
authors.lastname: Qian
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D004195:Disease Models, Animal; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat