Antiangiogenesis by chemotherapeutic agents.
Many tumors are not curable because current treatments primarily target the tumor cells. Intratumoral endothelial cells, on the other hand, proliferate rapidly and are sensitive to the cytotoxic effects of chemotherapeutic agents. This review summarizes the literature concerning the antiangiogenic effects of these agents when administered alone or in combination with other angiogenesis inhibitors.
Ribatti
Domenico
D
Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy. ribatti@anatomia.uniba.it
Vacca
Angelo
A
Merchionne
Francesca
F
Presta
Marco
M
D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents