Structure-based systems biology: a zoom lens for the cell.
Systems biology seeks to explain complex biological systems, such as the cell, through the integration of many different types of information. Here, we discuss how the incorporation of high-resolution structural data can provide key molecular details often necessary to understand the complex connection between individual molecules and cell behavior. We suggest a process of zooming on the cell, from global networks through pathways to the precise atomic contacts at the interfaces of interacting proteins.
Aloy
Patrick
P
EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. aloy@embl.de
Russell
Robert B
RB
D000818:Animals; D019295:Computational Biology; D003198:Computer Simulation; D030562:Databases, Protein; D006801:Humans; D007700:Kinetics; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry* / Q000502:physiology
D011506:Proteins