Effect of clopidogrel with and without aspirin on bleeding following transbronchial lung biopsy.
BACKGROUND
Clopidogrel, a potent inhibitor of platelet aggregation, is being commonly prescribed in the elderly population due to its benefits in patients with atherosclerotic diseases. It is currently unknown whether clopidogrel increases the risk of bleeding during invasive pulmonary procedures.


METHODS
Pigs of the Yorkshire species were randomized to one of the following two arms: clopidogrel (75 mg/d) alone; or clopidogrel plus aspirin (75 mg/d and 325 mg/d, respectively). The animals underwent flexible bronchoscopy with transbronchial lung biopsies under fluoroscopic guidance at baseline and after 1 week of daily oral intake of their assigned drugs. The main outcome of the study was the quantity of blood collected through the bronchoscope following transbronchial lung biopsy (TBLB).


RESULTS
Sixteen animals were enrolled in the study, with 8 animals randomized to each arm. No statistically significant difference was found in the average quantity of blood resulting from transbronchial lung biopsies between procedures performed at baseline and those performed after animals received either clopidogrel (mean [+/- SD] dose, 1.41 +/- 1.14 mL) or clopidogrel plus aspirin (mean dose, 1.75 +/- 1.28 mL; p = 0.42).


CONCLUSIONS
Clopidogrel, with or without aspirin, does not increase bleeding complications after TBLB in healthy pigs.
Wahidi
Momen M
MM
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. wahid001@mc.duke.edu
Garland
Robert
R
Feller-Kopman
David
D
Herth
Felix
F
Becker
Heinrich D
HD
Ernst
Armin
A
D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D001707:Biopsy, Needle / Q000009:adverse effects*; D001999:Bronchoscopy; D000077144:Clopidogrel; D006470:Hemorrhage / Q000139:chemically induced*; D008168:Lung / Q000473:pathology*; D010975:Platelet Aggregation Inhibitors / Q000633:toxicity*; D013552:Swine; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000633:toxicity*
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin