[Hyperphosphatemia and parathyroid hyperplasia].
A hypophosphatemic patient with adult onset osteomalacia was treated with oral phosphate agents for more than 10 years, when tertiary hyperparathyroidism developed. Gene analysis of the enlarged four parathyroid glands revealed MEM1 gene abnormalities in the two glands and microsatellite instability in the one gland, suggesting that hyperphosphatemia per se was involved in the development of nodular hyperplasia or adenoma in this patient, irrespective of renal function.
Sato
K
K
Institute of Clinical Endocrinology, Tokyo Women's Medical University.