title: [SERM and SARM].
abstract: There has been recent evidence about unfavorable effects of estrogen, while selective estrogen receptor modulators (SERM) with estrogen agonist and antagonist actions in a tissue selective manner have been developed. Among them, raloxifen inhibits the risk of vertebral fractures to a similar degree with bisphosphonates. From the same strategy, the study of selective androgen receptor modulators (SARM) has been in progress for the treatment of osteoporosis.
authors.affiliation: Division of Endocrinology / Metabolism, Neurology, Hematology / Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kaji
authors.forename: Toshitsugu
authors.initials: T
authors.lastname: Sugimoto