A new synthetic method for alpha-alkoxycarbonyl iminium salt and its reaction with nucleophiles.
An iminium salt was easily prepared using the oxidation of amino ketene silyl acetal with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, and the subsequent nucleophilic addition to this iminium species proceeded efficiently to afford alpha-amino esters in good yields.
Shimizu
Makoto
M
Department of Chemistry for Materials, Mie University, Tsu, Mie 514-8507, Japan. mshimizu@chem.mie-u.ac.jp
Itou
Hiroyuki
H
Miura
Megumi
M