[Fractionation of the total extract of Khaya senegalensis Barks. Value of the formulation of an anti-inflammatory ointment].
The aim of this work was to compare the anti-inflammatory activity of the total extract of Khaya senegalensis Barks and its different fractions for optimizing the active ingredients which be used in the ointment formulation. For that, a fractionation was performed followed by anti-inflammatory tests based on the method of the croton oil induced oedema. Three fractions were obtained and the comparison of their activity with the one of the total extract has shown the following results: 37.10%, 45.65%, 22.30% and 22.36% respectively for the extract, fraction n1, fraction n2 and fraction n3. The statistical analysis ofthe results (Student Test; p = 0.05) have revealed that the fraction nl is significatively more active than the others. However, there was not a significant difference between the inhibition induced by the fraction n1 and the total extact one, even the mean value of this latter is lower. Therefore, it seems enough to use the total extract as active ingredient for developing an anti-inflammatory ointment.
Thioune
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Laboratoire de Pharmacie Galénique et Législation, Faculté de Médecine, Pharmacie et Odonto-stomatologie, UCAD-Sénégal.
Diallo
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Diop
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Ngom
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D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D029582:Meliaceae; D051379:Mice; D009824:Ointments; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D009824:Ointments; D010936:Plant Extracts