title: Neurosedative and muscle relaxant activities of aqueous extract of Bryophyllum pinnatum.
abstract: The saline leaf extract of Bryophyllum pinnatum was investigated on neuropharmacological activities to ascertain claims of local use. When tested in mice, it produced a dose-dependent prolongation of onset and duration of pentobarbitone-induced hypnosis, reduction of exploratory activities in the head-dip and evasion tests. Moreover, a dose-dependent muscle in-coordination was observed in the inclined screen, traction and climbing tests. It delayed onset to convulsion in both strychnine- and picrotoxin-induced seizures in addition to minimal protection against picrotoxin seizures.
authors.affiliation: Department of Pharmacology, Lagos State University College of Medicine, P.M.B. 21266, Ikeja, Lagos, Nigeria. kayodeyemitan@yahoo.com
authors.forename: O K
authors.initials: OK
authors.lastname: Yemitan
authors.forename: H M
authors.initials: HM
authors.lastname: Salahdeen
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D029627:Crassulaceae; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
chemical_list: D000927:Anticonvulsants; D009466:Neuromuscular Blocking Agents; D010936:Plant Extracts