Solid-phase synthesis of double-headed epoxysuccinyl activity-based probes for selective targeting of papain family cysteine proteases.
Verhelst
Steven H L
SH
Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Bogyo
Matthew
M
D000818:Animals; D001665:Binding Sites; D004800:Enzymes, Immobilized / Q000378:metabolism; D004852:Epoxy Compounds / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008099:Liver / Q000201:enzymology; D015335:Molecular Probes / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure; D010206:Papain / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D019802:Succinic Acid / Q000737:chemistry* / Q000378:metabolism*
D004800:Enzymes, Immobilized; D004852:Epoxy Compounds; D015335:Molecular Probes; D019802:Succinic Acid; D010206:Papain