Immunoenhancing effects of a new probiotic strain, Lactobacillus fermentum PL9005.
The immunoenhancing effects of Lactobacillus fermentum PL9005 were assessed via mouse intragastric inoculation. The number of immunoglobulin A-positive cells in the small intestine, CD4+ T lymphocytes in the peripheral blood, and the lymphocyte proliferation response to mitogen stimulation (lipopolysaccharide) increased in mice fed L. fermentum PL9005. The lactic acid concentration also increased dose dependently in the small intestine of mice fed L. fermentum PL9005. No differences were found in body weight, food intake, and clinical signs between mice fed L. fermentum PL9005 and the control group. Results indicated that L. fermentum PL9005 is a probiotic with immunoenhancing properties.
Park
Jong-Hwan
JH
Department of Laboratory Animal Medicine, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Korea.
Lee
Yeonhee
Y
Moon
Enpyo
E
Seok
Seung-Hyeok
SH
Cho
Sun-A
SA
Baek
Min-Won
MW
Lee
Hui-Young
HY
Kim
Dong-Jae
DJ
Park
Jae-Hak
JH
D000818:Animals; D005260:Female; D007070:Immunoglobulin A; D007421:Intestine, Small / Q000276:immunology*; D019344:Lactic Acid / Q000378:metabolism*; D007778:Lactobacillus / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D019936:Probiotics; D013047:Specific Pathogen-Free Organisms
D007070:Immunoglobulin A; D019344:Lactic Acid