title: Low erythrocyte folate, but not plasma vitamin B-12 or homocysteine,is associated with dementia in elderly Latinos.
abstract: The relationship between B vitamin status and cognitive function has been of interest for many years. There is evidence of relationships between intake and status of folate and vitamin B-12 with neurological, cognitive, and memory impairment, but results have been inconsistent. Plasma B-12, erythrocyte folate, methylmalonic acid,and homocysteine were evaluated as predictors of cognitive function in a large population based sample of Latino elderly living in the Sacramento, California region. The hypothesis tested was that low folate and/or B-12 status predicts cognitive function impairment and dementia. Logistic regression was used to examine the differences in B-vitamin status by cognitive function category. Erythrocyte folate was related to dementia after controlling for age, gender, education, income, diabetes diagnosis, serum creatinine, and depressive symptoms. The highest prevalence of low erythrocyte folate occurred in the Dementia group and was significantly higher than in the Normal group. Plasma B-12, MMA, Hcy, and prevalence of a normal values for these variables, were not significantly different among the cognitive function classes. We conclude that folate status is associated with dementia but that more research is needed on the relationship between vitaminB-12 status, Hcy and cognitive function to explore possible associations with these parameters.
authors.affiliation: University of California, Davis, CA, USA. Alison_Campbell@byu.edu
authors.forename: A K
authors.initials: AK
authors.lastname: Campbell
authors.forename: W J
authors.initials: WJ
authors.lastname: Jagust
authors.forename: D M
authors.initials: DM
authors.lastname: Mungas
authors.forename: J W
authors.initials: JW
authors.lastname: Miller
authors.forename: R
authors.initials: R
authors.lastname: Green
authors.forename: M N
authors.initials: MN
authors.lastname: Haan
authors.forename: L H
authors.initials: LH
authors.lastname: Allen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002140:California / Q000453:epidemiology; D015331:Cohort Studies; D003704:Dementia / Q000097:blood / Q000453:epidemiology* / Q000208:ethnology; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D005492:Folic Acid / Q000097:blood*; D006630:Hispanic or Latino; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D014805:Vitamin B 12 / Q000097:blood*
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12