title: Comparison of peritoneal equilibration test with 2.27% and 3.86% glucose dialysis solution.
abstract: BACKGROUND
  The standard Peritoneal Equilibration Test (PET) uses a 2.27% glucose dialysis solution in peritoneal dialysis (PD). A more hypertonic solution (3.86%) has recently been proposed to obtain further information about ultrafiltration (UF).
  
  
  OBJECTIVE
  To compare results in terms of peritoneal solute transport (4h-dialysate-to-plasma ratio, 4h-D/P) between 2.27% and 3.86% PET.
  
  
  METHODS
  23 patients on PD were randomized to form two groups, A and B. A 2.27% dextrose 2-L exchange was used in group A, followed on the same day by a 3.86% dextrose 2-L exchange, both with a 4-hour dwell (2.27% and 3.86% PET); in group B, the same treatment was administered in reverse. 4h-D/P of urea, creatinine and sodium at time 0, 60, 120 and 240 minutes and net UF were calculated for each PET and compared.
  
  
  RESULTS
  No significant statistical differences were found for the usual peritoneal transport indexes, 4h-D/P of urea and creatinine, between 2.27% and 3.86% PET, which produced almost identical results. The creatinine 4h-D/P were 0.67+/-0.09 vs. 0.66+/-0.10 (p= NS) and the urea 4h-D/P 0.91+/-0.04 vs. 0.90+/-0.04 (p= NS). The sodium D/P was lower at all times during the 3.86% PET: D/P60= 0.92+/-0.05 vs. 0.88+/-0.03, D/P120= 0.91+/-0.02 vs. 0.87+/-0.03, D/P240= 0.92+/-0.02 vs. 0.88+/-0.04 (p< 0.0001). The net UF was 478 +/- 175 vs. 936 +/- 233 mL respectively (p< 0.0001).
  
  
  CONCLUSIONS
  Our study suggests that a 3.86% PD solution could be used for PET instead of the 2.27% solution in order to assess peritoneal solute transport, as well as UF, while obtaining almost identical results as the 2.27% solution.
authors.affiliation: Nephrology and Dialysis Unit, Camposampiero (Padova)-Italy. marilena.cara@libero.it
authors.forename: Marilena
authors.initials: M
authors.lastname: Cara
authors.forename: Giovambattista
authors.initials: G
authors.lastname: Virga
authors.forename: Stefania
authors.initials: S
authors.lastname: Mastrosimone
authors.forename: Angelo
authors.initials: A
authors.lastname: Girotto
authors.forename: Vittorio
authors.initials: V
authors.lastname: Rossi
authors.forename: Angela
authors.initials: A
authors.lastname: D'Angelo
authors.forename: Luciana
authors.initials: L
authors.lastname: Bonfante
mesh_terms: D000328:Adult; D000368:Aged; D001692:Biological Transport; D003404:Creatinine / Q000032:analysis / Q000097:blood; D015314:Dialysis Solutions / Q000737:chemistry* / Q000493:pharmacokinetics*; D005260:Female; D005947:Glucose / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism*; D012964:Sodium / Q000032:analysis / Q000097:blood; D014462:Ultrafiltration; D014508:Urea / Q000032:analysis / Q000097:blood
chemical_list: D015314:Dialysis Solutions; D014508:Urea; D012964:Sodium; D003404:Creatinine; D005947:Glucose