title: Slightly elevated serum creatinine predicts renal failure requiring hemofiltration after cardiac surgery.
abstract: BACKGROUND
  Acute renal failure (ARF) after cardiac surgery is a serious adverse event that is associated with high perioperative mortality and prolonged hospitalization. The aim of our study was to evaluate pre- and intraoperative risk factors for the development of ARF requiring hemofiltration after cardiac surgery.
  
  
  METHODS
  From February 2002 through February 2003, 913 patients underwent cardiac surgery at our institution. Seventy-three patients developed ARF (8.1%), 16 patients were excluded from the study because of chronic end-stage renal insufficiency. Patient characteristics and operative variables were analyzed. A multivariate logistic regression analysis was performed to determine risk factors for ARF.
  
  
  RESULTS
  Patients who developed ARF were older (P < .001; odds ratio [OR], 1.084; 95% confidence interval [CI], 1.0371.133) than patients who did not develop ARF. Furthermore, cardiopulmonary bypass duration (P = .007; OR, 1.013; 95% CI, 1.004-1.032) and emergent surgery (P = .011; OR, 6.667; CI, 1.538-28.571) were predictive for development of ARF. The strongest predictor for ARF was a preoperative creatinine level >or=2 mg/dL (P < .001; OR, 97.519; 95% CI, 22.363425.252). Most interestingly, even moderately elevated preoperative creatinine levels (1.3-1.99 mg/dL) independently predict ARF after cardiac surgery (P = .001; OR, 3.838; 95% CI, 1.793-8.217).
  
  
  CONCLUSIONS
  Our data indicate that emergent surgery as well as advanced age and long duration of cardiopulmonary bypass independently predict ARF after cardiac surgery. Most importantly, even slightly impaired preoperative creatinine levels predict the development of ARF requiring hemofiltration after cardiac surgery.
authors.affiliation: Department of Anesthesia and Intensive Care Medicine, University of Innsbruck, Innsbruck, Austria. juliane.kilo@uklibk.ac.at
authors.forename: Juliane
authors.initials: J
authors.lastname: Kilo
authors.forename: Josef E
authors.initials: JE
authors.lastname: Margreiter
authors.forename: Elfriede
authors.initials: E
authors.lastname: Ruttmann
authors.forename: Guenther
authors.initials: G
authors.lastname: Laufer
authors.forename: Johannes O
authors.initials: JO
authors.lastname: Bonatti
mesh_terms: D000367:Age Factors; D001011:Aorta; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D003250:Constriction; D001026:Coronary Artery Bypass / Q000009:adverse effects; D003404:Creatinine / Q000097:blood*; D004632:Emergency Medical Services; D005112:Extracorporeal Circulation; D006349:Heart Valve Diseases / Q000601:surgery; D006440:Hemofiltration; D006801:Humans; D007432:Intraoperative Period; D016015:Logistic Models; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011300:Preoperative Care; D051437:Renal Insufficiency / Q000209:etiology* / Q000628:therapy*; D012307:Risk Factors; D013997:Time Factors
chemical_list: D003404:Creatinine