[Mesenchymal stem cell transplantation for myocardial reparation of rat experimental heart failure].
Mesenchymal stem cells (MSC) are resident pluripotent cells of bone marrow stroma. MSC have the ability to differentiate into osteoblasts, chondroblasts and adipocytes, neurons, glia and also into cardiomyocytes. The problem of MSC use in cell therapy of various diseases and in myocardial infarction therapy is widely discussed at present. The experiments were carried out on the inbred line Wistar--Kyoto rats. Myocardial experimental infarction (EI) was induced by left descending coronary artery ligation. MSC were isolated from bone marrow, cultivated in vitro and injected into the tail vein on the day of experimental infarction operation. It was shown that the structure of injured myocardium in experimental group significantly differed from that in control group. MSC transplantation led to inflammatory process acceleration and to increased angiogenesis in the damaged myocardium; also, live cardiomyocyte layers were detected in the scar. As a result, ventricular dilatation and overload of the border zone of infarct region decreased, no features of infarction relapse were shown in the border zone.
Krugliakov
P V
PV
Sokolova
I B
IB
Amineva
Kh K
KhK
Nekrasova
N N
NN
Viĭde
S V
SV
Cherednichenko
N N
NN
Zaritskiĭ
A Iu
AIu
Semernin
E N
EN
Kisliakova
T V
TV
Polyntsev
D G
DG
D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000502:physiology; D018919:Neovascularization, Physiologic; D051381:Rats; D011921:Rats, Inbred WKY; D020257:Ventricular Remodeling