title: Effect of GPi DBS on functional imaging of the brain in dystonia.
abstract: Five patients with idiopathic dystonic conditions, treated successfully with deep brain stimulation (DBS) of the globus pallidus internus (GPi), were studied using single-photon emission tomography (SPET) in order to evaluate brain perfusion in the presence and absence of DBS. Comparison was made between the "on" and "off" DBS scans on an individual basis and also as part of a group analysis. Whilst the individual data suggested great regional variation in cerebral perfusion between individuals, the results of the group analysis revealed several topographically similar areas of the brain where relative hyperperfusion in the absence of DBS was common to all patients. Based on these results we postulate on possible mechanisms for this phenomenon.
authors.affiliation: The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, UK.
authors.forename: John
authors.initials: J
authors.lastname: Yianni
authors.forename: Kevin
authors.initials: K
authors.lastname: Bradley
authors.forename: Nigel
authors.initials: N
authors.lastname: Soper
authors.forename: Valerie
authors.initials: V
authors.lastname: O'Sullivan
authors.forename: Dipankar
authors.initials: D
authors.lastname: Nandi
authors.forename: Ralph
authors.initials: R
authors.lastname: Gregory
authors.forename: John
authors.initials: J
authors.lastname: Stein
authors.forename: Tipu
authors.initials: T
authors.lastname: Aziz
mesh_terms: D000328:Adult; D000368:Aged; D046690:Deep Brain Stimulation; D004421:Dystonia / Q000000981:diagnostic imaging* / Q000628:therapy*; D005260:Female; D005917:Globus Pallidus / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D015899:Tomography, Emission-Computed, Single-Photon