title: Experience in implementing continuous arterial spin labeling on a commercial MR scanner.
abstract: Continuous arterial spin labeling (CASL) is a technique for performing quantitative perfusion measurements without the need for exogenous contrast agent administration. This technique has seen limited use in the clinic due to problems of poor sensitivity and the potential for artifacts. In addition, CASL requires the application of long-duration radiofrequency pulses and the acquisition of a large number of images, which can cause difficulties when implemented on commercial MR scanners. This work details our experience in implementing CASL on a commercial MR scanner for the measurement of cerebral blood flow, including pitfalls regarding hardware, radiofrequency energy deposition, and practical application in human subjects. Results of studies to determine the optimal acquisition procedures are also presented.
authors.affiliation: Department of Imaging Physics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030, USA.
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Steger
authors.forename: Edward F
authors.initials: EF
authors.lastname: Jackson
mesh_terms: D000328:Adult; D001158:Arteries / Q000033:anatomy & histology / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology* / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels
chemical_list: D013113:Spin Labels