[Effect of the GABA derivative phenibut on learning].
The learning effect of phenibut, a beta-phenyl derivative of the inhibitory neuromediator GABA, used in a subcutaneous dose of 40 mg/kg 2 hours before each experiment, was studied in rabbits. The injection of phenibut was shown to enhance not only the inhibitory, but also excitatory components of cerebral cortical neuronal responses to all applied stimuli. The findings support the concept that the GABAergic neuromediator system is involved in the elaboration of internal inhibition and explain the sense of intracerebral processes that ensure both the sedative properties of phenibut and its ability to improve patients' systemic tone and health status when brain dysfunctions are treated.
Shul'gina
G I
GI
Ziablitseva
E A
EA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D004569:Electroencephalography; D018682:GABA Agents / Q000008:administration & dosage*; D007279:Injections, Subcutaneous; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000378:metabolism
D018682:GABA Agents; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid