Controlling inflammation: a fat chance?
The inflammatory response protects the body against infection and injury but can itself become deregulated with deleterious consequences to the host. It is now clear that several endogenous biochemical pathways activated during defense reactions can counterregulate inflammation. New experimental evidence adds resolvin E1 to this group of endogenous inhibitors and provides further rationale for the beneficial effects of dietary supplementation with fish oils. It also highlights an unexpected twist in the pharmacology of aspirin.
Flower
Roderick J
RJ
The William Harvey Research Institute, London EC1M 6BQ, UK. r.j.flower@qmul.ac.uk
Perretti
Mauro
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000178:diet therapy* / Q000188:drug therapy* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D043562:Receptors, G-Protein-Coupled; D001241:Aspirin