Paranasal sinus involvement in acute lymphoblastic leukemia.
Acute lymphoblastic leukemia (ALL) is a hemopoietic malignancy of the bone marrow that rarely invades the sinonasal area. If infiltration of paranasal sinuses occurs, it may lead to rhinosinusitis and orbital complications that need aggressive treatment. In this report, a 26-year-old male patient who had a history of ALL and had one relapse, suffered from rapid progression of right periorbital pain and exophthalmos, which usually presented in patients with orbital complications of sinusitis. A sinus computed tomography showed right maxillary and ethmoid sinus opacification with orbital bone destruction. Urgent endoscopic sinus surgery (ESS) was performed for orbital decompression and histopathologic diagnosis. Pathology revealed lymphoblast infiltration and inflammation of respiratory mucosa. Subsequent bone marrow aspiration cytology confirmed the diagnosis of a second relapse of ALL. Obstructive causes of sinusitis should be evaluated in patients with ALL. ESS has proven to be effective in obtaining tissue for histopathologic diagnosis, and in treating patients with sinusitis with orbital complications.
Chang
Bo-Hung
BH
Department of Otolaryngology, Chang Gung Memorial Hospital, Taipei.
Chen
Ying-Lin
YL
Lee
Ta-Jen
TJ
Lee
Li-Ang
LA
Liao
Shuen-Kuei
SK
D000328:Adult; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000473:pathology* / Q000601:surgery; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012852:Sinusitis / Q000209:etiology* / Q000601:surgery; D014057:Tomography, X-Ray Computed