Liver failure and transplantation after itraconazole treatment for toenail onychomycosis.
Three weeks after completing a 4-pulse course of itraconazole for toenail onychomycosis, a 25-year-old woman patient developed severe liver crisis and required an emergency liver transplant. We report the case and discuss the use of itraconazole in onychomycosis and dermatomycoses.
Srebrnik
A
A
Department of Dermatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 64239 Israel. asrebrnik@hotmail.co.il
Levtov
S
S
Ben-Ami
R
R
Brenner
S
S
D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects* / Q000627:therapeutic use; D017093:Liver Failure / Q000139:chemically induced* / Q000601:surgery; D008111:Liver Function Tests; D016031:Liver Transplantation; D014009:Onychomycosis / Q000188:drug therapy*
D000935:Antifungal Agents; D017964:Itraconazole