title: [Leukapheresis in children with chronic myeloid leukemia and pulmonary leukostasis].
abstract: We present two patients with chronic myeloid leukemia and hyperleukocytosis above 350 x 10(9)/l causing the symptoms of pulmonary leukostasis. Therapeutic leukapheresis procedures with concomitant chemotherapy were initiated within 12 hours from the diagnosis. After the therapy commencement the general condition of the patients systematically improved and leukocytosis gradually decreased from the second day of treatment with disappearance of pulmonary leukostasis symptoms. Thanks to application of such treatment procedures during the cytoreductive period, severe complications related to leukostasis could be prevented.
authors.affiliation: Klinika Pediatrii, Hematologii i Onkologii Dzieciecej Slaskiej AM w Zabrzu. hematologia@sk1.zabrze.pl
authors.forename: Halina
authors.initials: H
authors.lastname: Bubała
authors.forename: Danuta
authors.initials: D
authors.lastname: Sońta-Jakimczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Janik-Moszant
authors.forename: Tomasz
authors.initials: T
authors.lastname: Szczepański
authors.forename: Renata
authors.initials: R
authors.lastname: Tomaszewska
authors.forename: Bozena
authors.initials: B
authors.lastname: Drybańska
authors.forename: Urszula
authors.initials: U
authors.lastname: Sierantowicz-Zdaniewicz
authors.forename: Ewa
authors.initials: E
authors.lastname: Frankiewicz
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007937:Leukapheresis; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000150:complications* / Q000628:therapy*; D007958:Leukocyte Count; D007964:Leukocytosis / Q000097:blood / Q000628:therapy*; D018921:Leukostasis / Q000209:etiology / Q000628:therapy*; D008171:Lung Diseases / Q000209:etiology / Q000628:therapy*; D008297:Male; D016896:Treatment Outcome