Cardiovascular potential of BM-derived stem and progenitor cells.
Observational and experimental studies suggest that BM-derived stem and progenitor cells may have the capacity to repair damaged cardiovascular tissue and initiate blood vessel growth in regions of ischemia. Despite controversies regarding transdifferentiation potential of adult stem cells, clinical trials are underway testing the hypothesis that BM cell-based approaches to a broad spectrum of cardiovascular diseases and disease presentations will be safe and effective strategies for patient management.
Cannon
R O
RO
Cardiovascular Branch NHLBI, NIH, Bethesda, Maryland 20892, USA.
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000628:therapy*; D002319:Cardiovascular System / Q000033:anatomy & histology; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology; D015444:Exercise; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000378:metabolism; D051379:Mice; D013234:Stem Cells / Q000502:physiology*
D016207:Cytokines; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors