title: Eccrine mucinous metaplasia associated with an apocrine cystadenoma.
abstract: Mucinous metaplasia occurs uncommonly in cutaneous pathology, usually at specialized anatomic locations (genitalia, palms, and soles) and within restricted pathologic contexts (inflammation and trauma). Here, we report a unique case of eccrine mucinous metaplasia associated with an apocrine cystadenoma. A 13-year-old girl had an asymptomatic, 4-mm nodule on the chest. Histopathology demonstrated a typical apocrine cystadenoma in the upper and middle dermis. Adjacent to this lesion was a cluster of coiled eccrine secretory glands, of which the inner layer was almost entirely replaced by benign-appearing cells containing abundant, non-sulfated acid mucopolysaccharides. At 10 months' follow up, there was no recurrence. Our case demonstrates that, very uncommonly, mucinous metaplasia may be associated with a pathogenetically separate, adjacent proliferative adenomatous lesion, in this instance, an apocrine cystadenoma.
authors.affiliation: Department of Pathology, University of Illinois at Chicago Medical Center, Chicago, IL 60637, USA.
authors.forename: J
authors.initials: J
authors.lastname: Jiang
authors.forename: V
authors.initials: V
authors.lastname: Petronic-Rosic
authors.forename: J
authors.initials: J
authors.lastname: Hoag
authors.forename: C R
authors.initials: CR
authors.lastname: Shea
mesh_terms: D000293:Adolescent; D001050:Apocrine Glands / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D018251:Hidrocystoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008679:Metaplasia / Q000378:metabolism / Q000473:pathology; D009077:Mucins / Q000378:metabolism*; D010503:Periodic Acid-Schiff Reaction; D013544:Sweat Gland Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D009077:Mucins