[Glucocorticoid-induced osteoporosis and anabolic effect of PTH on bone].
Glucocorticoid-induced osteoporosis(GIO)is the major cause of secondary osteoporosis, and prevention of GIO is thought to be essential to avoid bone fracture. Direct inhibitory effect of glucocorticoid on bone formation is considered as the main mechanism of GIO. Clinical guidelines have recommended that bisphosphonate is the first choice for the treatment of GIO. Bone mineral density in patients with GIO has recently been reported to be increased by the treatment with parathyroid hormone(PTH)at a low dose and by intermittent administration.
Ohnaka
Keizo
K
Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University.
Takayanagi
Ryoichi
R