title: [Two cases of urothelial cancer responsive to high-dose-intensity methotrexate vinblastine doxorubicin and cisplatin (M-VAC) therapy].
abstract: We report two cases of metastatic urothelial cancer treated with high-dose-intensity (HD) methotrexate vinblastine, doxorubicin and cisplatin (MVAC). After HD-MVAC, the size of primary and lymph node tumors decreased by 57-67% as compared with the standard M-VAC therapy. By shortening the dose interval, HD-MVAC may increase the anti-tumor effect without increasing side effects.
authors.affiliation: Department of Urology, Akita University School of Medicine.
authors.forename: Hisami
authors.initials: H
authors.lastname: Fukuda
authors.forename: Kenji
authors.initials: K
authors.lastname: Mitsumori
authors.forename: Shingo
authors.initials: S
authors.lastname: Minagawa
authors.forename: Teruaki
authors.initials: T
authors.lastname: Kumazawa
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Tadachi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Iinuma
authors.forename: Shigeru
authors.initials: S
authors.lastname: Satoh
authors.forename: Kazunari
authors.initials: K
authors.lastname: Satoh
authors.forename: Tomonori
authors.initials: T
authors.lastname: Habuchi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kato
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D009367:Neoplasm Staging; D020551:Pulse Therapy, Drug; D016896:Treatment Outcome; D014516:Ureteral Neoplasms / Q000188:drug therapy* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D014747:Vinblastine; D004317:Doxorubicin; D002945:Cisplatin; D008727:Methotrexate