Distribution of CCR5-delta32, CCR2-64I, and SDF1-3'A mutations in populations from the Brazilian Amazon region.
The frequency distribution of the CCR5-delta32, CCR2-64I, and SDF1-3'A alleles was studied in the urban population of Belém and in Afro-Brazilians, Amerindians, and Japanese immigrants in the state of Pará, Brazil. The results suggest that Amerindians may be genetically more susceptible to HIV-1 infection and disease progression than the other human groups studied.
De Pinho Lott Carvalhaes
Fernanda Andreza
FA
Laboratory of Human and Medical Genetics, Department of Pathology, Center for Biological Sciences, Federal University of Pará, 66075-900 Belém, Para, Brazil.
Cardoso
Greice Lemos
GL
Hamoy
Igor Guerreiro
IG
Liu
Yan Tat
YT
Guerreiro
João Farias
JF
D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D001938:Brazil; D018925:Chemokines / Q000235:genetics; D018450:Disease Progression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D005828:Genetics, Population; D005838:Genotype; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D007199:Indians, South American / Q000235:genetics; D007564:Japan / Q000208:ethnology; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D019713:Receptors, CCR5 / Q000235:genetics*
D018925:Chemokines; D019713:Receptors, CCR5