Highly regio- and stereoselective synthesis of tetrasubstituted cyclobutenes via cyclodimerization of alkynes mediated by zirconium.
Zirconium-induced cyclodimerization of a variety of heteroaryl-substituted alkynes is described. This method provides a facile synthesis of tetrasubstituted cyclobutenes with high regio- and diastereoselectivity. A ligand-induced reductive elimination mechanism accounting for this novel cyclodimerization is suggested.
Liu
Yuanhong
Y
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China. yhliu@mail.sioc.ac.cn
Liu
Meina
M
Song
Zhiquan
Z