title: Isovolumic relaxation flow propagation velocity in patients with diseases impairing ventricular relaxation.
abstract: To evaluate the propagation velocity of isovolumic relaxation flow within the left ventricle (IRFPV) associated with impaired ventricular relaxation, 49 patients with diseases known to impair ventricular relaxation (disease group) and 38 age-matched control subjects (control group) were studied. IRFPV was measured as the slope of the first aliasing velocity line segment of the isovolumic relaxation flow wave front in the color M-mode Doppler echocardiogram. Compared with the control group, the disease group had thicker interventricular septum and left ventricular posterior wall, more left ventricular mass, and lower early diastolic mitral annular velocity (8 +/- 3 vs 11 +/- 4 cm/s, P < .001), early (E) wave propagation velocity (47 +/- 16 vs 70 +/- 41 cm/s, P = .002), and IRFPV (193 +/- 149 vs 395 +/- 220 cm/s, P < .001). No matter in subgroup or whole population analysis, either the early diastolic mitral annular velocity or the E wave propagation velocity was selected as one of the determinants of IRFPV. In conclusion, diseases impairing ventricular relaxation may retard IRFPV.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, 100 Shih-Chuan First Rd, Kaoshsiung 807, Taiwan. wcvoon@giga.net.tw.
authors.forename: Wen-Chol
authors.initials: WC
authors.lastname: Voon
authors.forename: Ho-Ming
authors.initials: HM
authors.lastname: Su
authors.forename: Hsueh-Wei
authors.initials: HW
authors.lastname: Yen
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Lin
authors.forename: Chih-Sheng
authors.initials: CS
authors.lastname: Chu
authors.forename: Kun-Tai
authors.initials: KT
authors.lastname: Lee
authors.forename: Wen-Ter
authors.initials: WT
authors.lastname: Lai
authors.forename: Sheng-Hsiung
authors.initials: SH
authors.lastname: Sheu
mesh_terms: D001024:Aortic Valve Stenosis / Q000150:complications; D001783:Blood Flow Velocity / Q000502:physiology; D016022:Case-Control Studies; D003327:Coronary Disease / Q000150:complications; D048909:Diabetes Complications / Q000503:physiopathology; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*