Evaluation of the hypoglycemic effect and antioxidant activity of three Viscum album subspecies (European mistletoe) in streptozotocin-diabetic rats.
The acute hypoglycaemic effect of water and ethanolic extracts of three Viscum album subspecies, ssp. album, ssp. austriacum, ssp. abietis, were investigated in normoglycaemic and streptozotozocin-induced diabetic rats. Blood glucose level was measured according to glucose oxidase method. The antioxidant activity of these extracts was also studied in the liver, kidney and heart tissues of streptozotocin-induced diabetic rats after subacute administration. In order to determine antioxidant activity of extracts, tissue MDA and GSH levels were measured by using spectrophotometric methods. All results were compared with the diabetic control groups. The findings obtained in the experiments demonstrated that European mistletoe (Viscum album L.) subspecies possess potent antihyperglycaemic and antioxidant activity depending on host plant.
Orhan
Didem Deliorman
DD
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Hipodrom 6330, Ankara, Turkey.
Aslan
Mustafa
M
Sendogdu
Nilüfer
N
Ergun
Fatma
F
Yesilada
Erdem
E
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D000431:Ethanol; D005843:Geography; D006321:Heart / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007668:Kidney / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013311:Streptozocin / Q000009:adverse effects; D014044:Tolbutamide / Q000494:pharmacology; D028182:Viscum album / Q000737:chemistry*; D014867:Water
D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014867:Water; D000431:Ethanol; D013311:Streptozocin; D014044:Tolbutamide