title: Preimplantation genetic diagnosis to prevent disorders in children.
abstract: Preimplantation genetic diagnosis (PGD) is an alternative reproductive option for couples at risk of having a child affected with a genetic disorder. Although prenatal diagnosis (PND) has been available for many years, it is not acceptable to many owing to issues relating to termination of pregnancy. PGD involves assisted-reproductive technology, even though most couples undertaking it are fertile. However, if the treatment is successful, the couple will not have to consider PND. PGD is only available at a small number of centres and for a limited number of genetic conditions. It is a complex and time-consuming procedure. The success rate is around 20%, consequently, there is a relatively low chance of success and this requires careful consideration by couples who generally can become spontaneously pregnant. However, PGD is now more widely understood and available to all at the point of referral. This article sets out to explain the PGD procedure, its implications, limitations, and regulation in the UK and to discuss associated dilemmas.
authors.affiliation: New Guy's House, Guy's Hospital, London.
authors.forename: Alison
authors.initials: A
authors.lastname: Lashwood
mesh_terms: D005260:Female; D005817:Genetic Counseling; D030342:Genetic Diseases, Inborn / Q000517:prevention & control*; D006801:Humans; D016742:Preconception Care; D011247:Pregnancy; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted