title: Syntheses of quinolone hydrochloride enantiomers from synthons (R)- and (S)-2-methylpiperazine.
abstract: A series of R and S enantiomers of 7-(3-methylpiperazin-1-yl) quinolone derivatives were synthesized from (R)- and (S)-tert-butyl 2-methylpiperazine-1-carboxylate and tested for their antibacterial activities on 14 kinds of bacteria. Although no distinct difference in in vitro antibacterial activities was observed, 2-64-fold difference between R and S enantiomers was observed in approximately 52% of cases.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Meteria Medica, SIBS, Chinese Academy of Sciences, Graduate School of the CAS, 555 Zuchongzhi Road, Shanghai 201203, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Chun-Hao
authors.initials: CH
authors.lastname: Yang
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Xu
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Zhu
authors.forename: Jing-Rong
authors.initials: JR
authors.lastname: Cui
authors.forename: Xi-Han
authors.initials: XH
authors.lastname: Wu
authors.forename: Yu-Yuan
authors.initials: YY
authors.lastname: Xie
mesh_terms: D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D010879:Piperazines; D015363:Quinolones