title: Initial report of off-pump coronary artery bypass surgery as sole therapy for moderate ischemic mitral regurgitation: operative and intermediate-term outcome.
abstract: BACKGROUND
  Patients undergoing on-pump coronary artery bypass surgery (CAB) with coexistent moderate ischemic mitral regurgitation (IMR) have a significant mortality rate compared to patients without MR. The mortality rate is elevated both perioperatively (0%-12% mortality), as well as over a 1- and 2-year postoperative period (15%-25%). It is thought that some patients are best served by off-pump CAB (OPCAB); however, outcomes have not been reported for such patients with coexistent moderate IMR.
  
  
  METHODS
  We reviewed the independent database of patients undergoing OPCAB between 1995 and 2002 to find 989 patients, 17 (1.7%) of whom had moderate or moderately severe MR. Patients were contacted and clinical and echocardiographic data were obtained.
  
  
  RESULTS
  The patient group consisted of 11 men and 6 women (age, 65 +/- 15 years). The study group had a PA pressure of 52 +/- 14, creatinine of 1.6 +/- 0.7, and left ventricular ejection fraction of 43 +/- 18. Nine patients (53%) had advanced New York Heart Association (class III-IV) heart failure. Mortality rates perioperatively and at 1, 2, and 3 years were 0%, 6.25% (1/16), 12.5% (2/16), and 38% (4/8), respectively. At the time of this report, no patient had returned for a reparative procedure.
  
  
  CONCLUSIONS
  In patients felt to be best served by OPCAB with ischemic MR, operative and intermediate mortality rates are remarkably similar to those previously reported for on-pump series. These data underscore the continued need to understand which patients undergoing CAB require mitral valve problems to be addressed at the time of surgery.
authors.affiliation: The Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA. kharris@mplsheart.com
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Harris
authors.forename: Avinash
authors.initials: A
authors.lastname: Reddy
authors.forename: Dorothee
authors.initials: D
authors.lastname: Aepplii
authors.forename: Betsy
authors.initials: B
authors.lastname: Wilson
authors.forename: Robert W
authors.initials: RW
authors.lastname: Emery
mesh_terms: D000368:Aged; D002303:Cardiac Output, Low / Q000209:etiology / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000150:complications; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects / Q000401:mortality; D003404:Creatinine / Q000097:blood; D048909:Diabetes Complications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*; D012307:Risk Factors; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D003404:Creatinine