title: SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption.
abstract: Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.
authors.affiliation: Department of Medicine, University of California-San Francisco, San Francisco, California, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: McCormick
authors.forename: Vivek
authors.initials: V
authors.lastname: Bhalla
authors.forename: Alan C
authors.initials: AC
authors.lastname: Pao
authors.forename: David
authors.initials: D
authors.lastname: Pearce
mesh_terms: D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D053503:Epithelial Sodium Channels; D006801:Humans; D017874:Immediate-Early Proteins; D007668:Kidney / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels / Q000378:metabolism; D000099184:Serum-Glucocorticoid Regulated Kinases
chemical_list: D000450:Aldosterone; D053503:Epithelial Sodium Channels; D017874:Immediate-Early Proteins; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; D012964:Sodium; D015222:Sodium Channels; D000099184:Serum-Glucocorticoid Regulated Kinases