An Ets element regulates the transcription of the human 2B4 gene in natural killer cells.
2B4 (CD244) acts as an activation receptor on human NK cells, whereas it sends inhibitory signals in murine NK cells. A previous study indicated a prominent role for AP-1 in the transcription of 2B4 gene. To further understand the transcriptional regulation we analyzed the upstream positive regulatory region (-1151 to -704) of the 2B4 promoter. We have identified an Ets element that regulates the 2B4 gene transcription in an AP1 dependent manner.
Vaidya
Swapnil V
SV
Department of Molecular Biology and Immunology and Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Mathew
Porunelloor A
PA
D015703:Antigens, CD / Q000235:genetics*; D018983:DNA Footprinting; D003850:Deoxyribonuclease I / Q000378:metabolism; D024202:Electrophoretic Mobility Shift Assay; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology*; D008156:Luciferases; D008562:Membrane Glycoproteins / Q000235:genetics*; D016296:Mutagenesis; D009841:Oligonucleotides; D017434:Protein Structure, Tertiary / Q000235:genetics; D011971:Receptors, Immunologic / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D000071176:Signaling Lymphocytic Activation Molecule Family; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*
D015703:Antigens, CD; C084093:CD244 protein, human; D008562:Membrane Glycoproteins; D009841:Oligonucleotides; D011971:Receptors, Immunologic; D000071176:Signaling Lymphocytic Activation Molecule Family; D014157:Transcription Factors; D008156:Luciferases; D003850:Deoxyribonuclease I