[Pathogenesis of uremic secondary hyperparathyroidism].
It has been assumed that uremic parathyroid hyperplasia predominantly involves generalized polyclonal cellular proliferation, because of multigland involvement. However, the majority of uremic hyperplasias resected from patients with secondary hyperparathyroidism are monoclonal. The specific acquired genetic abnormalities would have a great role in providing this selective advantage of the parathyroid hyperplasia.
Imanishi
Yasuo
Y
Division of Metabolism, Endocrinology and Molecular Medicine Osaka City University Graduate School of Medicine.
Kobayashi
Keisuke
K