title: Effect of glycemic control on electrophysiologic changes of diabetic neuropathy in type 2 diabetic patients.
abstract: Diabetic neuropathy is a common complication of diabetes mellitus. Effective blood glucose control retards changes in nerve conduction velocity in type 1 diabetes. This study examined the relationship between glycemic control and electrophysiologic changes in diabetic neuropathy in 57 type 2 diabetic patients. Nerve conduction in the peroneal motor nerve, tibial motor nerve, and sural nerve were measured at study entry and at follow-up 24+/-3.12 months later. Changes in individual nerves are expressed as a percentage change (PC) and overall electrophysiologic changes are expressed as the sum of individual PCs. The PCs for peroneal motor nerve velocity, tibial motor nerve velocity, and sural nerve velocity were all lower in patients with a mean HbA1c of 8.5% or less compared with those in patients with a mean HbA1c of more than 8.5%, and SPCV (sum of PC in velocity) was significantly inversely correlated with mean HbA1c. However, there was no significant difference in SPCV in subjects with or without hypertension, hypertriglyceridemia, or low high-density lipoprotein cholesterol concentration. In conclusion, hyperglycemia is the most important etiology for electrophysiologic progression in type 2 diabetic patients. Furthermore, a mean HbA1c of more than 8.5% will result in significant deterioration in electrophysiology.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Chun-Chiang
authors.initials: CC
authors.lastname: Huang
authors.forename: Tien-Wen
authors.initials: TW
authors.lastname: Chen
authors.forename: Ming-Cheng
authors.initials: MC
authors.lastname: Weng
authors.forename: Chia-Ling
authors.initials: CL
authors.lastname: Lee
authors.forename: Hsiang-Chieh
authors.initials: HC
authors.lastname: Tseng
authors.forename: Mao-Hsiung
authors.initials: MH
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000209:etiology / Q000503:physiopathology*; D004594:Electrophysiology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006456:Hemoglobinuria / Q000209:etiology; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009417:Nerve Tissue / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin