Unusual association of multiple sclerosis with monoclonal gammopathy of undetermined significance (MGUS): two case reports.
We present two patients with demyelinating disease meeting the diagnostic criteria for multiple sclerosis. Both patients had IgG lambda monoclonal gammopathy in serum and cerebrospinal fluid associated with intrathecal antibody synthesis. This association is very unusual and it is not certain whether the co-occurrence of these disorders might be the result of a causal link between multiple sclerosis and monoclonal gammopathy or a fortuitous phenomenon.
Rentzos
Michael
M
Department of Neurology, Aeginition Hospital-Athens Medical School, Athens, Greece. mrentzos@med.uoa.gr
Michalopoulou
Maria
M
Gotosidis
Kostas
K
Caponi
Anna
A
Bonakis
Anastasios
A
Kilidireas
Kostas
K
Nikolaou
Chrissoula
C
D000911:Antibodies, Monoclonal / Q000097:blood / Q000134:cerebrospinal fluid; D000917:Antibody Formation; D001921:Brain / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D007525:Isoelectric Focusing; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000276:immunology; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis; D043025:Oligoclonal Bands / Q000097:blood / Q000134:cerebrospinal fluid; D013116:Spinal Cord / Q000276:immunology
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D043025:Oligoclonal Bands