Synthesis of latanoprost diastereoisomers.
A new synthesis of latanoprost diastereoisomers is described which utilizes a highly stereoselective Michael addition of higher-order cuprate to a chiral cyclopentenone derived from G-lactone in the crucial skeleton-forming step.
Obadalová
Iva
I
R&D Synthesis Group II, API Division, ZENTIVA VUFB, a.s., Prague, Czech Republic.
Pilarcík
Tomás
T
Slavíková
Markéta
M
Hájícek
Josef
J