A new synthesis of 2-substituted pyridines via aluminum chloride induced heteroarylation of arenes and heteroarenes.
[reaction: see text] We herein report a new synthesis of 2-(hetero)aryl-substituted pyridines via heteroarylation of arenes/heteroarenes through AlCl(3)-induced C-C bond-forming reactions. 2-Halopyridines bearing an electron-withdrawing group were reacted with a number of (hetero)arenes to give 2-aryl/heteroaryl-substituted pyridines in good yields.
Pal
Manojit
M
Chemistry-Discovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500049, India. manojitpal@drreddys.com
Batchu
Venkateswara Rao
VR
Dager
Indu
I
Swamy
Nalivela Kumara
NK
Padakanti
Srinivas
S
D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*
D017607:Aluminum Compounds; D002712:Chlorides; D011725:Pyridines; D000077410:Aluminum Chloride