title: Improvement of refractory rheumatoid arthritis-associated constrictive bronchiolitis with etanercept.
abstract: Rheumatoid arthritis (RA)-associated constrictive bronchiolitis is a severe condition with no established efficient treatment. A 55-year-old woman with seropositive RA developed rapidly progressive constrictive bronchiolitis confirmed by lung biopsy. Her clinical condition worsened despite steroids and azathioprine. Treatment with etanercept-a tumor necrosis factor (TNF)-alpha inhibitor-combined with methotrexate, resulted in a marked improvement of both her clinical condition and pulmonary function tests. Treatment with TNF-alpha inhibitors and methotrexate may be proposed in RA-associated constrictive bronchiolitis, a severe condition hitherto not amenable to improvement.
authors.affiliation: Service de Pneumologie-Centre des Maladies Orphelines Pulmonaires, Hôpital Cardiovasculaire et Pneumologique Louis Pradel-Université Claude Bernard-UMR 754, 69677 Lyon, France.
authors.forename: Alexis Benjamin
authors.initials: AB
authors.lastname: Cortot
authors.forename: Vincent
authors.initials: V
authors.lastname: Cottin
authors.forename: Pierre
authors.initials: P
authors.lastname: Miossec
authors.forename: Eric
authors.initials: E
authors.lastname: Fauchon
authors.forename: Françoise
authors.initials: F
authors.lastname: Thivolet-Béjui
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Cordier
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D001988:Bronchiolitis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004359:Drug Therapy, Combination; D004417:Dyspnea / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D000068800:Etanercept; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D016896:Treatment Outcome; D014797:Vital Capacity / Q000187:drug effects
chemical_list: D018501:Antirheumatic Agents; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D000068800:Etanercept; D008727:Methotrexate