title: A clinicopathological study on the long-term efficacy of tonsillectomy in patients with IgA nephropathy.
abstract: Our study evaluated the clinical efficacy of tonsillectomy on the long-term renal survival in patients with primary IgA nephropathy (IgAN). Forty-six patients underwent tonsillectomy, and 74 patients did not. The mean of follow-up duration of all patients was 197.0+/-29.3 months (61-339 months). The baseline clinical and histological data at renal biopsy were not statistically different between the two groups with and without tonsillectomy. Five (10.9%) of the tonsillectomy group reached end stage renal failure (ESRF), whereas 19 (25.8%) of the non-tonsillectomy group did. The chi-square test between the two groups showed a significant difference (p <0.05). The renal survival of the tonsillectomy group was significantly higher than that of the non-tonsillectomy group by the Kaplan-Meier method with log-rank test (p <0.05). The Cox regression model also revealed that tonsillectomy had a significant favorable impact on the renal survival in long-term follow-up duration (p <0.05). Although our study was done by retrospective analyses, all the results proved that tonsillectomy had significant favorable effects on the long-term renal survival in patients with IgAN.
authors.affiliation: Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. snishi@med.niigata-u.ac.jp
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nishi
authors.forename: Yuansheng
authors.initials: Y
authors.lastname: Xie
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Ueno
authors.forename: Naofumi
authors.initials: N
authors.lastname: Imai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Seitaro
authors.initials: S
authors.lastname: Iguchi
authors.forename: Sachiko
authors.initials: S
authors.lastname: Fukase
authors.forename: Honami
authors.initials: H
authors.lastname: Mori
authors.forename: Bassam
authors.initials: B
authors.lastname: Alchi
authors.forename: Hisaki
authors.initials: H
authors.lastname: Shimada
authors.forename: Masaaki
authors.initials: M
authors.lastname: Arakawa
authors.forename: Fumitake
authors.initials: F
authors.lastname: Gejyo
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy; D008297:Male; D006435:Renal Dialysis; D015996:Survival Rate; D014068:Tonsillectomy; D014069:Tonsillitis / Q000150:complications