Chronic inflammatory demyelinating polyradiculoneuropathy: MRI study of brain and spinal cord.
CNS demyelinating lesions have been reported in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). There are no studies of cord atrophy in CIDP. Ten patients with CIDP underwent brain and spinal cord MRI to investigate CNS demyelination and cord atrophy. No CNS demyelination was found, but the mean cervical cord area was significantly smaller in CIDP patients vs control subjects. Spinal cord atrophy may be related to degeneration secondary to axonal loss.
Laura
M
M
Centre for Neuromuscular Diseases and Department of Molecular Neurosciences, National Hospital for Neurology, London, UK.
Leong
W
W
Murray
N M F
NM
Ingle
G
G
Miszkiel
K A
KA
Altmann
D R
DR
Miller
D H
DH
Reilly
M M
MM
D000328:Adult; D000368:Aged; D001284:Atrophy / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D001369:Axons / Q000473:pathology; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002574:Cervical Vertebrae; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D013116:Spinal Cord / Q000473:pathology* / Q000503:physiopathology; D013118:Spinal Cord Diseases / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D013904:Thoracic Vertebrae; D014855:Wallerian Degeneration / Q000209:etiology / Q000473:pathology / Q000503:physiopathology