title: [Organizing pneumonia--analysis of 18 own cases].
abstract: Organizing pneumonia (OP) is a rarely diagnosed disease, however the incidence ratio was estimated as 6-7/100000. Disease can occur in cryptogenic form or as a secondary reaction to various noxious agents, drugs, and ionising radiation, as a concomitant disease to infections, lympho- and myeloproliferative disorders, and connective tissue diseases. Symptoms of OP are non-specific therefore lung biopsy and histological examination are necessary for diagnosis. Eighteen cases of OP, 15 women and 3 men, aged 40 to 76 years, are presented with analysis of clinicopathological characteristic and therapeutic problems. In all cases diagnosis was confirmed by open lung biopsy. In one case radiotherapy and in one trastuzumab treatment was the cause of OP. In further 3 women antibodies against Chlamydia pneumoniae and in one--against Mycoplasma pneumoniae were found in serum. Probably Hashimoto disease was the cause of one case. In 12 patients the OP was idiopathic. Majority of patients were treated by prednisone (0.5 mg/kg). In one patient regression without any treatment was noticed and in other one--after cessation of trastuzumab. Five women were treated by clarithromycin. In 3 of them regression was observed but in other 2 corticotherapy was necessary. The observation period ranged from 1 month to 9 years, mean 34 months.
authors.affiliation: III Kliniki Chorób Płuc Instytutu Gruźlicy i Chorób Płuc.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Radzikowska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Wiatr
authors.forename: Paweł
authors.initials: P
authors.lastname: Remiszewski
authors.forename: Iwona
authors.initials: I
authors.lastname: Bestry
authors.forename: Jacek
authors.initials: J
authors.lastname: Grudny
authors.forename: Renata
authors.initials: R
authors.lastname: Langfort
authors.forename: Janusz
authors.initials: J
authors.lastname: Szopiński
authors.forename: Jacek
authors.initials: J
authors.lastname: Zych
authors.forename: Monika
authors.initials: M
authors.lastname: Płodziszewska
authors.forename: Piotr
authors.initials: P
authors.lastname: Rudziński
authors.forename: Dariusz
authors.initials: D
authors.lastname: Gawryluk
authors.forename: Barbara
authors.initials: B
authors.lastname: Roszkowska
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Roszkowski
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D017291:Clarithromycin / Q000627:therapeutic use; D018549:Cryptogenic Organizing Pneumonia / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D017291:Clarithromycin; D011241:Prednisone