title: Non-rigid registration of a 3D ultrasound and a MR image data set of the female pelvic floor using a biomechanical model.
abstract: BACKGROUND
  The visual combination of different modalities is essential for many medical imaging applications in the field of Computer-Assisted medical Diagnosis (CAD) to enhance the clinical information content. Clinically, incontinence is a diagnosis with high clinical prevalence and morbidity rate. The search for a method to identify risk patients and to control the success of operations is still a challenging task. The conjunction of magnetic resonance (MR) and 3D ultrasound (US) image data sets could lead to a new clinical visual representation of the morphology as we show with corresponding data sets of the female anal canal with this paper.
  
  
  METHODS
  We present a feasibility study for a non-rigid registration technique based on a biomechanical model for MR and US image data sets of the female anal canal as a base for a new innovative clinical visual representation.
  
  
  RESULTS
  It is shown in this case study that the internal and external sphincter region could be registered elastically and the registration partially corrects the compression induced by the ultrasound transducer, so the MR data set showing the native anatomy is used as a frame for the US data set showing the same region with higher resolution but distorted by the transducer
  
  
  CONCLUSIONS
  The morphology is of special interest in the assessment of anal incontinence and the non-rigid registration of normal clinical MR and US image data sets is a new field of the adaptation of this method incorporating the advantages of both technologies.
authors.affiliation: Department of Medical Informatics, University Hospital Goettingen, Germany. verhey@med.uni-goettingen.de
authors.forename: Janko F
authors.initials: JF
authors.lastname: Verhey
authors.forename: Josef
authors.initials: J
authors.lastname: Wisser
authors.forename: Simon K
authors.initials: SK
authors.lastname: Warfield
authors.forename: Jan
authors.initials: J
authors.lastname: Rexilius
authors.forename: Ron
authors.initials: R
authors.lastname: Kikinis
mesh_terms: D000465:Algorithms; D001696:Biomechanical Phenomena / Q000379:methods; D003198:Computer Simulation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D010388:Pelvis / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014463:Ultrasonography / Q000379:methods*