title: Teaching resources. Protein domains that interact with receptor tyrosine kinases: structural aspects.
abstract: This Teaching Resource provides lecture notes and slides for a class covering insights gained from structural analysis of the regulation of receptor tyrosine kinases and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with an overview of the many protein domains thus far implicated in cell signaling and then describes in detail the phosphotyrosine-binding domain (PTB). The application of structural information to rational drug design by targeting protein interaction domains is also covered.
authors.affiliation: Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA. ming-ming.zhou@mssm.edu <ming-ming.zhou@mssm.edu>
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Zhou
mesh_terms: D001296:Audiovisual Aids; D001695:Biology / Q000193:education*; D015195:Drug Design; D004500:Education, Graduate; D006801:Humans; D025941:Protein Interaction Mapping; D017434:Protein Structure, Tertiary; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D020794:Receptor Protein-Tyrosine Kinases