title: Anaplastic transformation from papillary thyroid carcinoma with increased serum CA19-9.
abstract: A 24-year-old woman presented with anaplastic transformation from papillary thyroid carcinoma with increased serum CA19-9. The patient had been diagnosed as having papillary thyroid carcinoma with lung metastasis at 11 years of age. She received a total thyroidectomy with cervical lymph node dissection followed by iodine-131 ((131)I) therapy over 12 years, but died due to sudden onset of rapid dissemination. Elevated serum CA19-9 was detected in the terminal stage, and anaplastic transformation was confirmed by post-mortem examination. Although there are few clinical reports suggesting a prognostic indicator for anaplastic thyroid carcinoma, CA19-9 may be a useful serum marker for this tumor.
authors.affiliation: Department of Pediatrics, Mie University School of Medicine, Tue, Mie 514-8507, Japan. ogwmshr@yahoo.co.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ogawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hori
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hirayama
authors.forename: Minako
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Taizou
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Yuri
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Komada
mesh_terms: D000328:Adult; D000708:Anaplasia / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood*; D002277:Carcinoma / Q000097:blood* / Q000556:secondary; D002291:Carcinoma, Papillary / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D013964:Thyroid Neoplasms / Q000097:blood* / Q000473:pathology* / Q000556:secondary
chemical_list: D018395:CA-19-9 Antigen