Metalloantimalarials: synthesis and characterization of a novel agent possessing activity against Plasmodium falciparum.
The synthesis, characterization, and antimalarial potency of an amine-phenol complex of gallium(III), [{1,12-bis(2-hydroxy-3-methoxy-5-(quinolin-3-yl)-benzyl)-1,5,8,12-tetraazadodecane}-gallium(III)]+, [Ga-3-M-5-Quadd]+ (7) is described; a novel agent that targets Plasmodium falciparum strains.
Ocheskey
Joseph A
JA
Mallinckrodt Institute of Radiology, Washington University Medical School, St. Louis, MO, USA.
Harpstrite
Scott E
SE
Oksman
Anna
A
Goldberg
Daniel E
DE
Sharma
Vijay
V
D000588:Amines / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005708:Gallium / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D021261:Parasitic Sensitivity Tests; D010636:Phenols / Q000737:chemistry / Q000378:metabolism; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development
C517926:((1,12-bis(2-hydroxy-3-methoxy-5-(quinolin-3-yl)-benzyl)-1,5,8,12-tetraazadodecane)-gallium(III))+; D000588:Amines; D000962:Antimalarials; D009942:Organometallic Compounds; D010636:Phenols; D005708:Gallium