Nuclear translocation of beta-catenin in developing auditory epithelia of mice.
Beta-catenin, a protein component of adherens junctions, plays a role in the signalling pathway for cell proliferation. In this study, we examined the cellular distribution of beta-catenin in developing auditory epithelia of mice. Immunohistochemistry for Ki67 and cyclin D indicated active cell proliferation in premature auditory epithelia. In this period, the nuclear localization of beta-catenin in epithelial cells was observed together with expression of the lymphoid enhancer factor, a transcription factor in beta-catenin signalling. Epithelial cells showing nuclear localization of beta-catenin disappeared at the same time, as there was a decrease of cell proliferation. These findings indicate that nuclear translocation of beta-catenin plays a role in cell proliferation in developing auditory epithelia.
Takebayashi
Shinji
S
Department of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Nakagawa
Takayuki
T
Kojima
Ken
K
Kim
Tae-Soo
TS
Endo
Tsuyoshi
T
Iguchi
Fukuichiro
F
Kita
Tomoko
T
Yamamoto
Norio
N
Ito
Juichi
J
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000818:Animals; D015153:Blotting, Western / Q000379:methods; D002467:Cell Nucleus / Q000378:metabolism*; D003051:Cochlea; D056741:Cyclin D; D016213:Cyclins / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D004622:Embryo, Mammalian; D004848:Epithelium / Q000196:embryology / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D007150:Immunohistochemistry / Q000379:methods; D019394:Ki-67 Antigen / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011247:Pregnancy; D011804:Quinolines / Q000378:metabolism; D013844:Thiazoles / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism*; D051176:beta Catenin
C495267:CTNNB1 protein, mouse; D056741:Cyclin D; D016213:Cyclins; D003598:Cytoskeletal Proteins; D019394:Ki-67 Antigen; D011804:Quinolines; C495966:TOTO-3 compound; D013844:Thiazoles; D015534:Trans-Activators; D051176:beta Catenin; D019869:Phosphatidylinositol 3-Kinases