title: Quantitative analysis of beta-blockers in pharmaceutical preparations by capillary electrophoresis.
abstract: A simple capillary electrophoresis method was developed for the analysis of four beta-blockers (atenolol, metoprolol, pindolol, and propranolol) in pharmaceutical preparations. The method was validated regarding accuracy, precision, linearity, and detection/quantification limits, and the obtained values were in accordance to those reported in the literature. The method was applied to the determination of the drugs in commercial tablet preparations and proved to be fast and reliable for the quantitative analysis of the beta-blockers.
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP 14040-903, Brazil.
authors.forename: Ana Cecília
authors.initials: AC
authors.lastname: Coragem Briguenti
authors.forename: Pierina Sueli
authors.initials: PS
authors.lastname: Bonato
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D019075:Electrophoresis, Capillary; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013607:Tablets / Q000032:analysis
chemical_list: D000319:Adrenergic beta-Antagonists; D004364:Pharmaceutical Preparations; D013607:Tablets