title: [Inhibition of joint destruction by methotrexate].
abstract: Methotrexate (MTX) plays an important role in treatment of rheumatoid arthritis (RA). It significantly reduce expected radiographic progression. Comparing with other traditional disease-modifying anti-rheumatic drugs (DMARDs), MTX slow radiographic progression during the first 2 years. Since combination with anti-tumor nectosis factor alpha (TNF-alpha) therapy has been shown to be effective for the early supression of disease activity, it could be usefull to minimize bone destruction in RA.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Tokai University.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Wakabayashi
authors.forename: Kanako
authors.initials: K
authors.lastname: Jackson
authors.forename: Chiho
authors.initials: C
authors.lastname: Yamada
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suzuki