title: High-sensitivity serum C-reactive protein levels in subjects with or without myocardial infarction or periodontitis.
abstract: BACKGROUND
  Serum high-sensitivity C-reactive protein (hsC-rp) is a non-specific marker of inflammation. Elevated hsC-rp levels are found in subjects with cardiovascular diseases (CVDs). Periodontitis may influence hsC-rp levels.
  
  
  OBJECTIVE
  To assess periodontal status and hsC-rp serum levels in consecutive subjects hospitalized and diagnosed with acute myocardial infarction (AMI) (n=85) and in a group of carefully matched subjects (gender, age social, ethnic, and smoking habits) without clinical evidence of CVD (n=63).
  
  
  METHODS
  hsC-rp levels, other routine serum values, and clinical periodontal conditions were studied.
  
  
  RESULTS
  Subjects with AMI had higher hsC-rp levels than control subjects (p<0.001, Mann-Whitney U-test). The odds that subjects in the control group with periodontitis (30% or more sites with>4.0 mm loss of alveolar bone) had serum hsC-rp>1.8 mg/l was 1.5 (95% CI: 1.1-7.3, p<0.05). Stepwise linear regression analysis failed to include periodontal parameters in an explanatory model to hsC-rp values. Only the serum leucocyte (white blood cell (WBC)) counts were explanatory to hsC-rp values (beta standard coefficient=0.45, t=3.2, p<0.001). Serum WBC counts were significantly higher in control subjects with periodontitis (p<0.03) but not in subjects in the AMI group (p<0.57).
  
  
  CONCLUSIONS
  (1) As expected, elevated serum hsC-rp concentration and serum WBC counts are associated with acute coronary heart disease. (2) Elevated serum hsC-rp values are associated with radiographically defined periodontitis in subjects with no evidence of CVD. (3) Periodontal parameters are not explanatory to elevated serum hsC-rp values if serum WBC and low-density lipoprotein counts are included in the regression model.
authors.affiliation: Department of Periodontics, University of Washington, Seattle, WA, USA. rutger.persson@zmk.unibe.ch
authors.forename: G Rutger
authors.initials: GR
authors.lastname: Persson
authors.forename: Thomas
authors.initials: T
authors.lastname: Pettersson
authors.forename: Ola
authors.initials: O
authors.lastname: Ohlsson
authors.forename: Stefan
authors.initials: S
authors.lastname: Renvert
mesh_terms: D016301:Alveolar Bone Loss / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D005884:Gingival Hemorrhage / Q000097:blood; D006801:Humans; D007958:Leukocyte Count; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D017622:Periodontal Attachment Loss / Q000097:blood; D010514:Periodontal Pocket / Q000097:blood; D010518:Periodontitis / Q000097:blood*
chemical_list: D008077:Lipoproteins, LDL; D002097:C-Reactive Protein