[Change in plasma free 15 - F2t - isoprostane concentrations in smoking patients undergoing coronary artery bypass grafting and its clinical significance].
OBJECTIVE
To investigate the change in plasma free 15-F2t-isoprostane fn(15-F(2t)-IsoP) concentration and its relationship with postoperative cardiac function of smoking patients who underwent coronary artery bypass grafting (CABG).


METHODS
Sixty patients with coronary artery heart disease were divided into smoking group [n=30, age 54-69 years old, American Heart Association (AHA)II-III] and non-smoking group(n=30, age 58-70 years old, ASA II-III). All the patients were scheduled for CABG under combination anesthesia with isoflurane and fentanyl and conventional cardiopulmonary bypass. Blood samples were drawn from the central vein to measure 15-F(2t)-IsoP at the following time points: before operation (T0); 30 minutes after aortic clamping for cardiopulmonary bypass(T1); 10 and 30 minutes after aortic declamping(T2,T3).


RESULTS
There was no statistical difference in 15-F(2t)-IsoP between two groups at T0, but contents of 15-F(2t)-IsoP in the two groups was increased markedly at T1, compared to those at T0 (P<0.05 and P<0.01 for smoking and non-smoking groups, respectively), and the degree of increase of 15-F(2t)-IsoP in smoking group was significantly higher than that in non-smoking group(P<0.05). During reperfusion period (at T2,T3), the rate of lowering of 15-F(2t)-IsoP in smoking group was slower than that in non-smoking group(P<0.05), and moreover, these patients needed more inotropic support than those in non-smoking group.


CONCLUSIONS
Smoking patients have weaker anti-oxidation capability during CABG, therefore they have higher incidence of low cardiac function.
Yao
Bin
B
Department of Anesthesiology, Sun Yat-sen Cardiovascular Hospital, Shenzhen 518020, Guangdong, China. yaob@szheart.info
Jiang
Hong-ying
HY
Xia
Zheng-yuan
ZY
Huang
Zhi-yong
ZY
D000368:Aged; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D028421:Isoprostanes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects*
D028421:Isoprostanes