title: Acute toxicity of textile dye wastewaters (untreated and treated) of Sanganer on male reproductive systems of albino rats and mice.
abstract: This study reports on the toxic effects of 15-days oral administration of untreated (Influent) and treated (Effluent) textile dye wastewaters on male reproductive systems of adult Swiss albino rats (age: 85-90 days) and mice (40-50 days). Textile dye wastewaters decreased body weight (7-25%) and reproductive organ weight (testis, epididymis, prostate gland and seminal vesicle, 2-48%). Similar trends were noted for total protein (14-70%), cholesterol (14-91%) and total lipid (10-30%) content of reproductive organs and spermatozoa, and for fructose levels in seminal vesicle (18-44%). Acid phosphatase activity in prostate however, was increased (11-44%) in the wastewater-exposed animals. Histopathological studies of treated animals revealed altered spermatogenesis, with higher sperm abnormalities, reduction in sperm counts (10-59%), and altered motility (14-56%). The magnitude of these abnormalities was stronger in rats versus mice, while among treatments, it was stronger in the Influent animals. Adverse effects improved when treated rats were allowed to recover 45 days in the control condition. Only recovered Effluent rats were capable of fertilizing normal females indicating that treated wastewater was less toxic; however, in comparison to control rats, litter size and body weight gains of F(1) and F(2) generations were adversely affected. Thus, the present study has established toxicity of both untreated and treated textile dye wastewater on reproductive biology of male Albino mice and rats.
authors.affiliation: Department of Zoology, University of Rajasthan, Jaipur 302004, Rajasthan, India.
authors.forename: V
authors.initials: V
authors.lastname: Suryavathi
authors.forename: Subhasini
authors.initials: S
authors.lastname: Sharma
authors.forename: Shweta
authors.initials: S
authors.lastname: Sharma
authors.forename: Pratibha
authors.initials: P
authors.lastname: Saxena
authors.forename: Shipra
authors.initials: S
authors.lastname: Pandey
authors.forename: Ruby
authors.initials: R
authors.lastname: Grover
authors.forename: Suresh
authors.initials: S
authors.lastname: Kumar
authors.forename: K P
authors.initials: KP
authors.lastname: Sharma
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D004396:Coloring Agents / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005632:Fructose / Q000378:metabolism; D005837:Genitalia, Male / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D007220:Industrial Waste; D050356:Lipid Metabolism; D008098:Litter Size; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects / Q000473:pathology; D013783:Textile Industry; D023382:Toxicity Tests, Acute; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D004396:Coloring Agents; D007220:Industrial Waste; D011506:Proteins; D014874:Water Pollutants, Chemical; D005632:Fructose; D000135:Acid Phosphatase