title: Genetic selection for high acute inflammatory response confers resistance to lung carcinogenesis in the mouse.
abstract: Mice selected for a high acute inflammatory response (AIRmax) are resistant to chemically induced lung tumorigenesis, whereas the low responders (AIRmin) are susceptible. In urethane-treated mice, anti-inflammatory drugs increased the tumor incidence in AIRmax but not AIRmin mice, and an inverse correlation (P<.001) between the degree of acute inflammatory response (AIR) and lung tumorigenesis was found in an F2 (AIRmax x AIRmin) intercross population. The results provide evidence for the involvement of lung tumor modifier loci in AIR regulation and implicate AIR quantitative trait loci in the inherited predisposition to lung cancer.
authors.affiliation: Laboratório de Immunogenética, Instituto Butantan, São Paulo, SP, Brazil.
authors.forename: Orlando Garcia
authors.initials: OG
authors.lastname: Ribeiro
authors.forename: Wafa Hanna
authors.initials: WH
authors.lastname: Cabrera
authors.forename: Durvanei Augusto
authors.initials: DA
authors.lastname: Maria
authors.forename: Marcelo
authors.initials: M
authors.lastname: De Franco
authors.forename: Solange
authors.initials: S
authors.lastname: Massa
authors.forename: Roberto Francisco
authors.initials: RF
authors.lastname: Di Pace
authors.forename: Vinicius Ricardo Cuña
authors.initials: VR
authors.lastname: de Souza
authors.forename: Nancy
authors.initials: N
authors.lastname: Starobinas
authors.forename: Michel
authors.initials: M
authors.lastname: Semen
authors.forename: Olga Martinez
authors.initials: OM
authors.lastname: Ibañez
mesh_terms: D000208:Acute Disease; D000230:Adenocarcinoma / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D007249:Inflammation / Q000235:genetics* / Q000473:pathology; D007958:Leukocyte Count; D008175:Lung Neoplasms / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D019655:Quantitative Trait, Heritable; D012641:Selection, Genetic; D014520:Urethane / Q000633:toxicity
chemical_list: D002273:Carcinogens; D014520:Urethane