title: Bilateral nodular lymphocytic conjunctivitis in a horse.
abstract: A Russian jumper horse presented because of an ocular perilimbal conjunctival mass and, on clinical examination, two bilateral conjunctival masses were found, of different size and conformation. Attempts at complete excision of the left eye mass and excisional biopsy of the right eye mass were performed. The left eye mass recurred rapidly, but resolved completely after topical corticosteroid therapy. The two lesions had similar histopathologic features, characterized by focal, chronic, primarily lymphocytic conjunctivitis with follicular lymphoid hyperplasia. Special histopathologic staining techniques (Gomori methenamine silver and acid fast stains) and immunohistochemistry (for CD3, BLA36 and lysozyme) failed to reveal any etiologic agents and indicated an inflammatory lesion composed of a heterogeneous population of lymphocytes and macrophages (nodular lymphocytic conjunctivitis). The lesions were indistinguishable, clinically and behaviorally, from what has been reported as 'conjunctival pseudotumor' in the horse. Equine conjunctival pseudotumor/nodular lymphocytic conjunctivitis has been reported to be unilateral and have a good prognosis after partial or complete surgical excision. This is the first reported case of bilateral nodular lymphocytic conjunctivitis in a horse and for which surgical excision alone was not curative.
authors.affiliation: Solo Practitioner, Via Pace 24, 25122 Brescia, Italy. stopric@tin.it
authors.forename: Riccardo
authors.initials: R
authors.lastname: Stoppini
authors.forename: Brian C
authors.initials: BC
authors.lastname: Gilger
authors.forename: David E
authors.initials: DE
authors.lastname: Malarkey
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ratto
authors.forename: Giampiero
authors.initials: G
authors.lastname: Brigati
mesh_terms: D000818:Animals; D003230:Conjunctival Neoplasms / Q000175:diagnosis / Q000662:veterinary*; D003937:Diagnosis, Differential; D006734:Horse Diseases / Q000175:diagnosis* / Q000473:pathology; D006736:Horses; D007150:Immunohistochemistry / Q000662:veterinary; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000662:veterinary*; D008297:Male