[Lung cancer screening -- state of the art].
Besides smoking as the main risk factor for lung cancer several occupational risk factors like exposure to asbestos, polycyclic aromatic hydrocarbons, uranium and dust containing nickel or silica have to be considered. Due to lack of effort in smoking prevention and cessation, lung cancer screening is an important issue. A number of pitfalls has to be considered when evaluating the efficacy of screening procedures. In this paper, we summarize the results of the major studies including chest X-ray, sputum cytology and low dose computed tomography. Randomized controlled studies involving low dose CT in about 100 000 subjects are on the way. Around the year 2010 we will be able to define whether or not lung cancer screening including new techniques and standardized algorithms yields a decrease in mortality. If diagnostic algorithms are used which have been applied in published feasibility studies, the mean percentage of invasive diagnostic measures revealing benign lesions is about 34 % and thus below those obtained in, e. g., breast cancer screening trials.
Nowak
D
D
Institut und Poliklinik für Arbeits- und Umweltmedizin der Universität München, München. dennis.nowak@med.uni-muenchen.de
Ochmann
U
U
Huber
R M
RM
Diederich
S
S
D005858:Germany; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D008403:Mass Screening / Q000592:standards*; D009784:Occupational Diseases / Q000175:diagnosis / Q000453:epidemiology; D013902:Radiography, Thoracic; D012307:Risk Factors