title: Acute biliary pancreatitis: does the pancreas change morphologically in the long term?
abstract: The objective of the study was to assess by means of magnetic resonance cholangiopancreatography whether acute biliary pancreatitis leads to alterations in pancreatic morphology and the main pancreatic duct; to establish whether such alterations are related to the severity of the acute episode and if they are to be considered as sequelae of the illness or on the contrary the findings constitute diagnostic morphological criteria of chronic pancreatitis. Forty patients with acute biliary pancreatitis were prospectively and consecutively studied, 15 female (37.5%) and 25 male (62.5%). During the acute phase the severity was assessed according to the Atlanta criteria. During subsequent follow-up,we assessed the morphology of the gland and the main pancreatic duct with magnetic resonance cholangiopancreatography 5 years after the episode of pancreatitis, and compared the findings with the findings from a control group. We administered secretin in 16 of the study group cases when visualization of the duct was incomplete or absent. The statistical study of diameter and length showed significant differences in the main pancreatic duct of the case and control groups. No relationship was found between the severity of the illness and morphological alterations of the pancreas after pancreatitis. The statistical analysis, which compared the diameter and the length of the main pancreatic duct before and after the injection of secretin in the study group showed significant differences. We conclude that after acute biliary pancreatitis, in the long term, scarring lesions are detected, which are considered to be sequelae of the acute episode, unrelated to its severity. Secretin stimulation improved visualization of the main pancreatic duct in the magnetic resonance cholangiopancreatography.
authors.affiliation: Department of Surgery, General University Hospital of Valencia, Valencia, Spain. eugeniapareja@wanadoo.es
authors.forename: Eugenia
authors.initials: E
authors.lastname: Pareja
authors.forename: José
authors.initials: J
authors.lastname: Mir
authors.forename: Enrique
authors.initials: E
authors.lastname: Artigues
authors.forename: Vicente
authors.initials: V
authors.lastname: Martínez
authors.forename: Ricardo
authors.initials: R
authors.lastname: Fabra
authors.forename: Ramón
authors.initials: R
authors.lastname: Trullenque
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001660:Biliary Tract Diseases / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology*; D010183:Pancreatic Ducts / Q000473:pathology; D010195:Pancreatitis / Q000209:etiology / Q000473:pathology*; D011446:Prospective Studies; D012633:Secretin / Q000502:physiology
chemical_list: D012633:Secretin