Hemocompatibility of poly(acrylonitrile-co-N-vinyl-2-pyrrolidone)s: swelling behavior and water states.
Hemocompatibility is an essential aspect of blood contacting polymers. Knowledge of the relationship between polymer structure and hemocompatibility is important in designing such polymers. In this work, the effect of swelling behavior and states of water on the hemocompatibility of poly(acrylonitrile-co-N-vinyl-2-pyrrolidone) (PANCNVP) films was studied. Platelet adhesion and plasma recalcification time tests were used to evaluate the hemocompatibility of the films. Considering the importance of surface properties on the hemocompatibility of polymers, static water contact angles were measured by both sessile drop and captive bubble methods. It was found that, on the film surface of PANCNVP with a higher NVP content, adhered platelets were remarkably suppressed and the recalcification time was longer. The total water content adsorbed on the PANCNVP film was determined through swelling experiments performed at temperatures of interest. Differential scanning calorimetry and thermogravimetric analysis were used to probe the states of water in the films. Based on the results from these experiments, it was hypothesized that the better hemocompatibility of PANCNVP films with higher NVP contents was due to their higher free water content, because water molecule exchange at the polymer/liquid interface, facilitated by a high free water content, is unfavorable for the formation of surface bound water, which causes poor hemocompatibility. [diagram in text].
Wan
Ling-Shu
LS
Institute of Polymer Science, Zhejiang University, Hangzhou 310027, P. R. China.
Xu
Zhi-Kang
ZK
Huang
Xiao-Jun
XJ
Wang
Zhen-Gang
ZG
Ye
Peng
P
D000180:Acrylic Resins / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001769:Blood; D002113:Calcification, Physiologic; D002118:Calcium / Q000097:blood / Q000737:chemistry; D006801:Humans; D010973:Platelet Adhesiveness; D011205:Povidone / Q000737:chemistry*; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D000180:Acrylic Resins; D001672:Biocompatible Materials; D014867:Water; C010504:polyacrylonitrile; D011205:Povidone; D002118:Calcium