[Effects of hyper- and dyslipidemias on activity of angiotensin-converting enzyme (biochemical disturbances in metabolic syndrome)].
OBJECTIVE
To study influence of lipoprotein complexes on activity of angiotensin-converting enzyme (ACE). Material and methods. Lipoproteins fraction was isolated from the serum of 53 healthy males and females and was studied for lipoproteins action on ACE in vitro. In addition, the examination covered 783 individuals. The data were analysed mathematically for relationships between ACE activity and parameters of lipid metabolism.


RESULTS
It was found that blood serum lipoproteins inhibit activity of soluble ACE. Serum ACE activity depends on concentration of total cholesterol (TC) and triglycerides. Maximal activity of ACE is observed in TC 9.41 mM/l and TG concentration 3.05 mM/l. Albumin-related free fatty acids affect ACE activity neither in aqueous solution nor in the presence of lipoprotein complexes.


CONCLUSIONS
. Development of most common atherogenic hyperlipidemias raises 2-fold plasma ACE activity. Elevated ACE activity may be an integral component of biochemical disturbances in metabolic syndrome.
Al'tshuler
B Iu
BIu
Roĭtman
A P
AP
Dolgov
V V
VV
Sokolov
A V
AV
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004586:Electrophoresis; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000201:enzymology*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000201:enzymology*; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol; D007703:Peptidyl-Dipeptidase A