Preparation and characterization of a novel bioactive bone cement: glass based nanoscale hydroxyapatite bone cement.
A novel type of glass-based nanoscale hydorxypatite (HAP) bioactive bone cement (designed as GBNHAPC) was synthesized by adding nanoscale hydroxyapatite (HAP) crystalline (20-40 nm), into the self-setting glass-based bone cement (GBC). The inhibition rate of nanoscale HAP and micron HAP on osteosarcoma U2-OS cells was examined. The effects of nanoscale HAP on the crystal phase, microstructure and compressive strength of GBNHAPC were studied respectively. It was concluded that nanoscale HAP could inhibit the cell proliferation, while micron HAP could not, and that nanoscale HAP could be dispersed in the cement evenly and the morphology did not change significantly after a longer immersion time. XRD and FTIR results show nanoscale HAP did not affect the setting reaction of the cement. Furthermore, GBNHAPC had a higher compressive strength (92 MPa) than GBC. It was believed that GBNHAPC might be a desirable biomaterial that could not only fill bone defects but also inhibit cancer cell growth.
Fu
Qiang
Q
School of Materials Science and Engineering, Tongji University, Shanghai, 200092, P.R. China.
Zhou
Nai
N
Huang
Wenhai
W
Wang
Deping
D
Zhang
Liying
L
Li
Haifeng
H
D001843:Bone Cements / Q000737:chemistry*; D045744:Cell Line, Tumor; D017886:Durapatite / Q000737:chemistry*; D005898:Glass; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology; D012516:Osteosarcoma / Q000473:pathology
D001843:Bone Cements; D017886:Durapatite