Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sl(d) mice.
Studies were carried out to evaluate the impact of a high-fat dietary regimen on aortic wall thickness, peripheral blood leukocyte profile, and plasma cholesterol and triglyceride levels in the mast cell-deficient Sl/Sl(d) mouse. The results demonstrated that the mean aortic wall thickness of Sl/Sl(d) mice was significantly higher than their normal littermates, and were increased in both genotypes after a 17-day high-fat regimen. In comparison with normal littermates, Sl/Sl(d) genotypes had elevated levels of plasma triglycerides with normal levels of plasma cholesterol, and the high-fat diet markedly lowered the triglyceride levels. Total peripheral blood leukocytes, the monocyte and granulocyte counts, and hemoglobin levels were significantly lower in Sl/Sl(d) mice, although the number of lymphocytes, eosinophils and basophils were the same in both genotypes. Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sl(d) mice.
Dileepan
Kottarappat N
KN
Division of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA. kdileepan@kumc.edu
Johnston
Thomas P
TP
Li
Yuai
Y
Tawfik
Ossama
O
Stechschulte
Daniel J
DJ
D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology*; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology / Q000473:pathology; D005260:Female; D006098:Granulocytes / Q000473:pathology*; D007958:Leukocyte Count; D019891:Leukopoiesis; D008407:Mast Cells / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides