title: Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries.
abstract: Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder characterized by ineffective hematopoiesis and leukemia progression. Racial differences may exist on clinical pictures and the molecular events leading to MDS, which are heterogeneous. To better define the clinical and cytogenetic features in Chinese patients, a retrospective multicentric study was performed in 508 MDS cases. Compared with Western countries, Chinese patients showed younger age (median: 49 vs 65-73 years), lower percentages of RARS (2.8 vs 6.6-15.3%), and CMML (5.2 vs 11.7-30.6%). Cytogenetically, among 367 cases with evaluable data, abnormal karyotypes were found in 136 cases, including 56 numerical and 80 structural changes. Incidences of single chromosome 5 and 7 abnormalities were lower than those in Western countries (2.2 vs 17.8-42.5%). However, complex cytogenetic aberrations and chromosome translocations were frequently observed and related to poor prognosis. Both multiple chromosome deletions and translocations were detected in advanced subtypes (RAEB and RAEB-T). Analysis of 200 cases revealed a higher incidence of hepatitis-B-virus infection than that in non-MDS population (21.00 vs 9.75%). This study further confirmed: (1) different genetic/environmental backgrounds between Asian and Western MDS populations; (2) a strong predictive value of cytogenetic abnormalities on disease outcome and involvement of genomic instability in leukemia clone development.
authors.affiliation: State Key Lab for Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, China.
authors.forename: B
authors.initials: B
authors.lastname: Chen
authors.forename: W-L
authors.initials: WL
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: Jin
authors.forename: Y-Q
authors.initials: YQ
authors.lastname: Xue
authors.forename: X
authors.initials: X
authors.lastname: Cheng
authors.forename: X-T
authors.initials: XT
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Cui
authors.forename: Z-M
authors.initials: ZM
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Cao
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Yao
authors.forename: H-L
authors.initials: HL
authors.lastname: Xia
authors.forename: J-H
authors.initials: JH
authors.lastname: Tong
authors.forename: J-M
authors.initials: JM
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: S-M
authors.initials: SM
authors.lastname: Xiong
authors.forename: Z-X
authors.initials: ZX
authors.lastname: Shen
authors.forename: S
authors.initials: S
authors.lastname: Waxman
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: S-J
authors.initials: SJ
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002681:China; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis / Q000379:methods; D003582:Cytogenetics; D019049:Developed Countries; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome