Melatonin, refractory hypertension, myocardial ischemia and other challenges in nightly blood pressure lowering.
A test of the relative merits of timed melatonin for the treatment of cardiac ischemia as well as hypertension refractory to other drugs is documented against the background of earlier chronobiological studies on blood pressure (BP), disease risks, circadian hyper-amplitude-tension and melatonin effects broadly.
Zaslavskaya
Rina Mikhailovna
RM
Department of Cardiology, Hospital 60, Moscow, Russia.
Lilitsa
Galina Victorovna
GV
Dilmagambetova
G S
GS
Halberg
Franz
F
Cornélissen
Germaine
G
Otsuka
Kuniaki
K
Singh
Ram B
RB
Stoynev
Alexander
A
Ikonomov
Ognian
O
Tarquini
Roberto
R
Perfetto
Federico
F
Schwartzkopff
Othild
O
Bakken
Earl E
EE
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D019454:Chronotherapy / Q000379:methods; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008550:Melatonin / Q000008:administration & dosage / Q000627:therapeutic use*; D015201:Meta-Analysis as Topic; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D017211:Treatment Failure
D008550:Melatonin