title: Trisomy 12 and t(14;22)(q32;q11) in a patient with B-cell chronic lymphocytic leukemia.
abstract: Recurrent cytogenetic abnormalities are typically found in about one third of B-cell chronic lymphocytic leukemia patients (B-CLL) by standard cytogenetic analysis and their prognostic relevance is well known. We report a case of a B-CLL patient showing both trisomy 12 and a t(14;22)(q32;q11). Trisomy 12 is often associated with aggressive disease and resistance to chemotherapy, however, our patient is in good health and currently untreated after 7 years, suggesting in this case a relatively good prognosis and a questionable role for translocations involving the 14q32 locus.
authors.affiliation: Department of Medicine and Immunological Sciences, Division of Hematology and Transplants, University of Siena, Italy. gozzetti@unisi.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Gozzetti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Marotta
authors.forename: Mariapia
authors.initials: M
authors.lastname: Lenoci
authors.forename: Rosaria
authors.initials: R
authors.lastname: Crupi
authors.forename: Daniela
authors.initials: D
authors.lastname: Tozzuoli
authors.forename: Simona
authors.initials: S
authors.lastname: Calabrese
authors.forename: Francesco
authors.initials: F
authors.lastname: Forconi
authors.forename: Alberto
authors.initials: A
authors.lastname: Fabbri
authors.forename: Francesco
authors.initials: F
authors.lastname: Lauria
mesh_terms: D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D002892:Chromosomes, Human, Pair 22; D020732:Cytogenetic Analysis; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged; D014178:Translocation, Genetic; D014314:Trisomy