title: Patterns of brain activation in patients with mild Alzheimer's disease during performance of subtraction: an fMRI study.
abstract: We performed a functional MRI (fMRI) study to compare the difference of activation between healthy aged people and patients with mild Alzheimer's disease (AD) during performance of subtraction. Nine patients with mild AD and nine healthy aged volunteers were recruited in this study. The analysis of fMRI data revealed that brain activation is decreased in several regions in AD patients in comparison with healthy participants. But in the right inferior prefrontal lobe, activation is greater in patients than in the controls. We believe that our findings will help the understanding mechanism of neuronal activity in AD.
authors.affiliation: Department of Radiology, Peking University First Hospital, Peking 100034, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Xie
authors.forename: Jiang Xi
authors.initials: JX
authors.lastname: Xiao
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
authors.forename: Xue Xiang
authors.initials: XX
authors.lastname: Jiang
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008433:Mathematics; D008606:Mental Processes; D009483:Neuropsychological Tests; D013647:Task Performance and Analysis