title: A randomised controlled trial comparing low dose vaginal misoprostol and dinoprostone vaginal gel for inducing labour at term.
abstract: OBJECTIVE
  To compare the efficacy of low dose vaginal misoprostol and dinoprostone vaginal gel for induction of labour at term.
  
  
  METHODS
  A single-blind randomised controlled trial.
  
  
  METHODS
  Antenatal and labour ward of a UK district general hospital.
  
  
  METHODS
  Two hundred and sixty-eight women requiring induction of labour at term (>37 weeks of gestation) with no significant fetal or medical condition, no previous uterine surgery and no contraindication to prostaglandin.
  
  
  METHODS
  Misoprostol 25 microg (one-quarter of a 100 microg tablet) was inserted into the posterior vaginal fornix every 4 hours (to a maximum of six doses) or dinoprostone vaginal gel 1-2 mg 6 hourly (maximum of 3 mg in 24 hours).
  
  
  METHODS
  Induction-to-vaginal delivery interval.
  
  
  METHODS
  Requirements for oxytocin, mode of delivery, number of women delivering < 24 hours, incidence of uterine contraction abnormalities, incidence of abnormal cardiotocograph (CTG) recordings, 5-minute Apgar scores, umbilical cord pH recordings, analgesia requirements, admission to NICU and blood loss at delivery.
  
  
  RESULTS
  There were no significant differences between the two groups in induction-to-vaginal delivery interval, mode of delivery, number of women delivering within 24 hours and neonatal outcomes. The incidence of uterine contraction abnormalities (tachysystole and hyperstimulation) and the incidence of abnormal CTG recordings were also similar for both groups.
  
  
  CONCLUSIONS
  Low dose vaginal misoprostol is as effective as dinoprostone gel for inducing labour at term. There would be substantial cost savings, estimated at around 3.9 million UK pounds per annum, for maternity services if low dose misoprostol became the agent of choice for inducing labour in the UK.
authors.affiliation: Maternity Unit, Queen Mary's Sidcup NHS Trust, Frognal Avenue, Sidcup, Kent DA14 6LT, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Gregson
authors.forename: Mark
authors.initials: M
authors.lastname: Waterstone
authors.forename: Ian
authors.initials: I
authors.lastname: Norman
authors.forename: Trevor
authors.initials: T
authors.lastname: Murrells
mesh_terms: D000282:Administration, Intravaginal; D036861:Delivery, Obstetric; D015232:Dinoprostone; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D016595:Misoprostol; D010120:Oxytocics; D011247:Pregnancy; D011273:Pregnancy, Prolonged; D016037:Single-Blind Method; D014622:Vaginal Creams, Foams, and Jellies
chemical_list: D010120:Oxytocics; D014622:Vaginal Creams, Foams, and Jellies; D016595:Misoprostol; D015232:Dinoprostone