title: Metastatic gastric tumor secondary to pancreatic adenocarcinoma.
abstract: Metastatic disease, from the pancreas, involving the stomach is an unusual clinical event. Local recurrence, liver metastases, and peritoneal spread are the most common recurrent patterns after curative resection of pancreatic cancer. We report a patient who suffered from gastric metastasis secondary to pancreatic adenocarcinoma 1 year after pancreatectomy. A 49-year-old woman underwent distal pancreatectomy with intraoperative radiation therapy for cancer of the body of the pancreas in October 2002. The histological diagnosis was well-differentiated adenocarcinoma of the pancreas, stage IIB; T1N1M0. Multiple liver metastases were detected on computed tomography (CT) in March 2003. Combination chemotherapy of 5-fluorouracil hepatic arterial continuous infusion and systemic gemcitabine administration led to the disappearance of the liver metastases on CT in September 2003. One month later, she complained of epigastric pain and underwent gastric endoscopy, which revealed a submucosal tumor in the fornix posterior wall. Histological diagnosis of the biopsy specimen was well-differentiated adenocarcinoma, and immunohistochemical studies, using anti-cytokeratin 7 and -20 monoclonal antibodies, were compatible with gastric metastasis from pancreatic carcinoma. A F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) scan revealed a high-uptake lesion, which coincided with the gastric tumor. No other abnormal uptake could be found. Histopatholoical examination of the resected specimen revealed submucosal growth of the metastatic cancer (well-differentiated adenocarcinoma).
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takamori
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Kanemitsu
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Tsuji
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kusano
authors.forename: Akira
authors.initials: A
authors.lastname: Chikamoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Okuma
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Iyama
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary* / Q000601:surgery; D018395:CA-19-9 Antigen / Q000097:blood; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000556:secondary*; D013997:Time Factors
chemical_list: D018395:CA-19-9 Antigen