The effect of subthalamic nucleus stimulation on kinaesthesia in Parkinson's disease.
BACKGROUND
Parkinson's disease is accompanied by deficits in passive motion and limb position sense.


OBJECTIVE
To investigate whether deep brain stimulation of the subthalamic nucleus (STN-DBS) reverses these proprioceptive deficits.


RESULTS
A passive movement task was applied to nine patients with Parkinson's disease and bilateral chronic STN-DBS and to seven controls. Thresholds for 75% correct responses were 0.9 degrees for controls, 2.5 degrees for Parkinson's disease patients when stimulation was OFF, and 2.0 degrees when stimulation was ON.


CONCLUSIONS
STN-DBS improves kinaesthesic deficits in Parkinson's disease, but does not lead to a full recovery of proprioceptive function.
Maschke
M
M
Sensorimotor Control Laboratory, Division of Kinesiology, University of Minnesota, Minneapolis, MN, USA. matthias.maschke@uni-essen.de
Tuite
P J
PJ
Pickett
K
K
Wächter
T
T
Konczak
J
J
D000328:Adult; D000368:Aged; D046690:Deep Brain Stimulation; D005260:Female; D006801:Humans; D007699:Kinesthesis / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D020127:Recovery of Function; D020531:Subthalamic Nucleus / Q000503:physiopathology*