title: Mammotome: less invasive than ABBI with similar accuracy for early breast cancer detection.
abstract: We performed a prospective analysis of two consecutive biopsy cohorts investigated by the same team to compare the Mammotome system with the ABBI procedure. From April 1997 to August 2003 a series of 413 nonpalpable mammographic lesions in 387 women (median age 56 years, range 30-84 years) were stereotactically biopsied in the University Hospital of Basel, Switzerland. Until October 1999 the ABBI system was applied exclusively, it was subsequently superseded by the Mammotome device in our clinic. Main outcome measures were accuracy, technical demand, and morbidity. Sensitivity (97.3%/96.8%), negative predictive value (99.2%/98.7%), and diagnostic accuracy (99.4%/99.1%) regarding the detection of malignancy were excellent for both techniques (ABBI/ Mammotome). The Mammotome procedure was faster and less invasive, thus causing significantly less morbidity. The larger specimen obtained by the ABBI procedure resulted in more detailed histology. In conclusion, recommend the Mammotome system as the method of choice for detecting nonpalpable early breast cancer.
authors.affiliation: Department of Surgery, University of Basel, Spitalstrasse 21, Basel, CH-4031 Switzerland.
authors.forename: Walter P
authors.initials: WP
authors.lastname: Weber
authors.forename: Rosanna
authors.initials: R
authors.lastname: Zanetti
authors.forename: Igor
authors.initials: I
authors.lastname: Langer
authors.forename: Sophie
authors.initials: S
authors.lastname: Dellas
authors.forename: Markus
authors.initials: M
authors.lastname: Zuber
authors.forename: Holger
authors.initials: H
authors.lastname: Moch
authors.forename: Eugenia
authors.initials: E
authors.lastname: Remmel
authors.forename: Daniel
authors.initials: D
authors.lastname: Oertli
authors.forename: Edward
authors.initials: E
authors.lastname: Wight
authors.forename: Walter R
authors.initials: WR
authors.lastname: Marti
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000295:instrumentation*; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity