title: Divergent host responses during primary simian immunodeficiency virus SIVsm infection of natural sooty mangabey and nonnatural rhesus macaque hosts.
abstract: To understand how natural sooty mangabey hosts avoid AIDS despite high levels of simian immunodeficiency virus (SIV) SIVsm replication, we inoculated mangabeys and nonnatural rhesus macaque hosts with an identical inoculum of uncloned SIVsm. The unpassaged virus established infection with high-level viral replication in both macaques and mangabeys. A species-specific, divergent immune response to SIV was evident from the first days of infection and maintained in the chronic phase, with macaques showing immediate and persistent T-cell proliferation, whereas mangabeys displayed little T-cell proliferation, suggesting subdued cellular immune responses to SIV. Importantly, only macaques developed (CD4+)-T-cell depletion and AIDS, thus indicating that in mangabeys limited immune activation is a key mechanism to avoid immunodeficiency despite high levels of SIVsm replication. These studies demonstrate that it is the host response to infection, rather than properties inherent to the virus itself, that causes immunodeficiency in SIV-infected nonhuman primates.
authors.affiliation: Department of Medicine, Emory Vaccine Center, 954 Gatewood Rd., NE, Atlanta, GA 30329, USA.
authors.forename: Guido
authors.initials: G
authors.lastname: Silvestri
authors.forename: Andrew
authors.initials: A
authors.lastname: Fedanov
authors.forename: Stephanie
authors.initials: S
authors.lastname: Germon
authors.forename: Natalia
authors.initials: N
authors.lastname: Kozyr
authors.forename: William J
authors.initials: WJ
authors.lastname: Kaiser
authors.forename: David A
authors.initials: DA
authors.lastname: Garber
authors.forename: Harold
authors.initials: H
authors.lastname: McClure
authors.forename: Mark B
authors.initials: MB
authors.lastname: Feinberg
authors.forename: Silvija I
authors.initials: SI
authors.lastname: Staprans
mesh_terms: D000818:Animals; D017209:Apoptosis; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D049109:Cell Proliferation; D016665:Cercocebus atys / Q000276:immunology* / Q000821:virology; D005260:Female; D008198:Lymph Nodes / Q000473:pathology; D008213:Lymphocyte Activation; D008253:Macaca mulatta / Q000276:immunology* / Q000821:virology; D008297:Male; D012367:RNA, Viral / Q000097:blood; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology*; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*; D014766:Viremia; D014779:Virus Replication
chemical_list: D012367:RNA, Viral