title: [Herpes encephalitis at children].
abstract: Significant mortality, high incidences of complications and permanent neurological sequel are still noted in patients suffering fro herpetic encephalitis. They result mainly from delayed diagnosis and treatment of the specific cause. The aim of our paper was the analysis o a clinical course of patients with Herpes simplex encephalitis. From 1999 to 2001 7 patients aged 2 weeks to 15 years, treated in Children' Neurology Department of Silesian School of Medicine, were diagnosed to have herpetic encephalitis. Fever, headache, vomiting, as well as alteration of consciousness, all typical for neuroinfection were main clinical symptoms present on admission. Three children presented with respiratory distress requiring admission to Intensive Care Unit. On examination "cold sores" were found in 2 patients, in remaining 5 the history of exposition to herpes labialis was obtained. On neurological examination we found either right or left hemiparesis in all patients, motor aphasia in 2 and left sided central facial nerve palsy in 1. Lumbar puncture revealed lymphocytosis in 5 patients. Anti-HSV type IgG an IgM antibodies were found in serum of all 6 patients, while only in 2 of them were detected in cerebrospinal fluid (CSF). These were the 2 most severely ill children. In 2 patients DNA HSV using PCR (polymerase chain reaction) method was found in CSF and in serum. Magnetic resonance imaging (MRI) of the head confirmed diagnosis. Although herpetic encephalitis is an uncommon, sporadic disease, the diagnosis should be considered in any child with neuroinfection and early treatment started before laboratory confirmation.
authors.affiliation: Kliniki Pediatrii i Neurologii, Wieku Rozwojowego Katedry Pediatrii, Slaskiej Akademii Medycznej w Katowicach.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Poliszuk-Siedlecka
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Wojaczyńska-Stanek
authors.forename: Ewa
authors.initials: E
authors.lastname: Jamroz
authors.forename: Ewa
authors.initials: E
authors.lastname: Stepień
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Marszał
mesh_terms: D000293:Adolescent; D001039:Aphasia, Broca / Q000209:etiology; D001921:Brain / Q000473:pathology* / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D020803:Encephalitis, Herpes Simplex / Q000097:blood / Q000150:complications / Q000473:pathology*; D005158:Facial Paralysis / Q000209:etiology; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D010291:Paresis / Q000209:etiology
chemical_list: D007075:Immunoglobulin M