title: Scavenging of reactive oxygen species by novel indolin-2-one and indoline-2-thione derivatives.
abstract: The antioxidant behavior of a series of new synthesized substituted indoline-2-ones and indolin-2-thiones was investigated in this study using an oxygen radical absorbance capacity assay (ORAC(ROO*-) and 2,2'-azobis(2-amidino-propane) dihydrochloride (AAPH) as the radical generator; system generating superoxide anion radical, O2*- (18-crown-6/KO(2)/DMSO), and the Fenton-like reaction [Co(II) + H(2)O(2) --> Co(III) + HO(*) + HO(-)]. Measurements were done using fluorescence, chemiluminescence methods, and a deoxyribose assay based on the spectrophotometry method, respectively. The results obtained indicated that the examined indoline derivatives had effective activities as radical scavengers and may be considered as an effective source for combating oxidative damage.
authors.affiliation: Bioanalytical and Drug Development Laboratory, Biological & Research Centre, P. O. Box 3354, Riyadh 11211, Saudi Arabia. enien@kfshrc.edu.sa
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Aboul-Enein
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kładna
authors.forename: Irena
authors.initials: I
authors.lastname: Kruk
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Lichszteld
authors.forename: Teresa
authors.initials: T
authors.lastname: Michalska
authors.forename: Sureyya
authors.initials: S
authors.lastname: Olgen
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D002384:Catalysis; D003855:Deoxyribose / Q000032:analysis / Q000378:metabolism; D016166:Free Radical Scavengers / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism*; D008163:Luminescent Measurements; D010100:Oxygen / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000378:metabolism; D013871:Thiones / Q000737:chemistry
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D007211:Indoles; D017382:Reactive Oxygen Species; D013871:Thiones; C456900:indolin-2-one; D013481:Superoxides; D017665:Hydroxyl Radical; D003855:Deoxyribose; C057812:indoline; D010100:Oxygen