title: [Local recurrence of pancreatic cancer successfully treated with gemcitabine].
abstract: We report a patient for whom systemic chemotherapy using gemcitabine was effective against local recurrence of pancreatic cancer. A 58-year-old man underwent pancreatoduodenectomy for a pancreatic head cancer. The diagnosis was Stage IVb poorly-differentiated tubular adenocarcinoma, scirrhous type, pT4, PL (+), P0, H0, pN2. However, after 21 months, gastrointestinal bleeding occurred. Gastroscopy and CT examination revealed a mass at the cut-end of the pancreas invading the stomach. The serum CA19-9 level was found to be elevated. Systemic chemotherapy was performed with a regimen of gemcitabine 1,000 mg/m2/week for 2 weeks, followed by a week rest. The recurrent tumor in the stomach disappeared, and the mass at the cut-end of the pancreas became small. The serum CA 19-9 level regained the normal value. Two years after the diagnosis of recurrence, he returned to work, and his chemotherapy is being continued as an outpatient.
authors.affiliation: Dept of Surgery, Tokyo Metropolitan Bokuto Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohmura
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Umekita
authors.forename: Takao
authors.initials: T
authors.lastname: Ohkubo
authors.forename: Souichi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Maeshiro
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsuo
authors.forename: Sachio
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Satoru
authors.initials: S
authors.lastname: Inoue
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Kitamura
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D016577:Pancreaticoduodenectomy; D011184:Postoperative Period; D011788:Quality of Life; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000556:secondary; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine