title: Harmonic phase-dispersion microscope with a Mach-Zehnder interferometer.
abstract: Harmonic phase-dispersion microscopy (PDM) is a new imaging technique in which contrast is provided by differences in refractive index at two harmonically related wavelengths. We report a new configuration of the harmonic phase-dispersion microscope in a Mach-Zehnder geometry as an instrument for imaging biological samples. Several improvements on the earlier design are demonstrated, including a single-pass configuration and acousto-optic modulators for generating the heterodyne signals without mechanical arm scanning. We demonstrate quantitative phase-dispersion images of test structures and biological samples.
authors.affiliation: G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Ahn
authors.forename: Changhuei
authors.initials: C
authors.lastname: Yang
authors.forename: Adam
authors.initials: A
authors.lastname: Wax
authors.forename: Gabriel
authors.initials: G
authors.lastname: Popescu
authors.forename: Christopher
authors.initials: C
authors.lastname: Fang-Yen
authors.forename: Kamran
authors.initials: K
authors.lastname: Badizadegan
authors.forename: Ramachandra R
authors.initials: RR
authors.lastname: Dasari
authors.forename: Michael S
authors.initials: MS
authors.lastname: Feld
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D008857:Microscopy, Interference / Q000295:instrumentation* / Q000379:methods; D008858:Microscopy, Phase-Contrast / Q000295:instrumentation* / Q000379:methods; D019697:Onions / Q000166:cytology*; D019047:Phantoms, Imaging