title: Pyrazolopyridine antiherpetics: SAR of C2' and C7 amine substituents.
abstract: A novel series of potent pyrazolo[1,5-a]pyridine inhibitors of herpes simplex virus 1 replication have been identified. Several complimentary synthetic methods were developed to allow facile access to a diverse set of analogs from common late stage intermediates. Detailed examination of the amine substituents at the C2' position of the pyrimidine and C7 position of the core pyrazolopyridine is described. The antiviral data suggests that non-polar amines are preferred for optimal activity. Additionally, the 2' position has been shown to require an NH group to retain activity levels similar to that of the gold standard acyclovir.
authors.affiliation: Department of Medicinal Chemistry, GlaxoSmithKline Research and Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA. brian.a.johns@gsk.com <brian.a.johns@gsk.com>
authors.forename: Brian A
authors.initials: BA
authors.lastname: Johns
authors.forename: Kristjan S
authors.initials: KS
authors.lastname: Gudmundsson
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Turner
authors.forename: Scott H
authors.initials: SH
authors.lastname: Allen
authors.forename: Vicente A
authors.initials: VA
authors.lastname: Samano
authors.forename: John A
authors.initials: JA
authors.lastname: Ray
authors.forename: George A
authors.initials: GA
authors.lastname: Freeman
authors.forename: F Leslie
authors.initials: FL
authors.lastname: Boyd
authors.forename: Connie J
authors.initials: CJ
authors.lastname: Sexton
authors.forename: Dean W
authors.initials: DW
authors.lastname: Selleseth
authors.forename: Katrina L
authors.initials: KL
authors.lastname: Creech
authors.forename: Kelly R
authors.initials: KR
authors.lastname: Moniri
mesh_terms: D000588:Amines / Q000737:chemistry*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D006564:Herpesviridae / Q000187:drug effects; D006568:Herpesvirus 1, Cercopithecine / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014709:Vero Cells
chemical_list: D000588:Amines; D000998:Antiviral Agents; D011720:Pyrazoles; D011725:Pyridines