[P53 under low-intensity inluence of physical and chemical nature (ionizing radiation and antioxidant)].
It was found that low-intensity ionizing radiation and the antioxidant fenozan at a low concentration (10(-14) M) produce opposite effects on the content of protein p53 in the blood serum of mice. Thus, low-intensity gamma-irradiation of AKR mice with a dose of 1.2 cGy (0.6 cGy per day) led to a decrease in the content of p53 and acceleration of leukosis, whereas fenozan, which has membranolytic and radioprotective properties, when injected intramuscularly to F1 mice (CBA + c57 black) increased the content of p53. However, the dynamics of the activation of protein p53 depended on the concentration of fenozan (10(-4) or 10(-14)), which may be due to the difference in its binding to the membrane and the changes in its antioxidative properties depending on concentration.
Mil'
E M
EM
Myshliakova
O V
OV
Burlakova
E B
EB
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005720:Gamma Rays; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010666:Phenylpropionates / Q000494:pharmacology*; D016159:Tumor Suppressor Protein p53 / Q000097:blood*
D000975:Antioxidants; D010666:Phenylpropionates; D016159:Tumor Suppressor Protein p53; C047854:fenozan