title: QF-PCR examination of parental and meiotic origin of trisomy 21 in Central and Eastern Europe.
abstract: Study of parental/meiotic origin of free trisomy 21 in nuclear families from Russia (70 cases), Ukraine (32 cases), and 22 from Germany revealed maternal nondisjunction in 77.3% (Germany), 93.8% (Ukraine), and 91.4% (Russia), paternal origin in 13.6%, 6.2%, and 8.6%, respectively. Maternal meiosis I errors were found in 84.4% (Ukraine), 77.1% (Russia), paternal origin in 3.1% (Ukraine), 2.9% (Russia). Maternal meiosis II errors occurred in 9.4% and 14.3% and paternal in 3.1% and 5.7% in Ukraine and Russia, respectively. No significant differences were found in maternal/paternal origin among Ukraine, Russia, Germany, and published data from other European regions.
authors.affiliation: University Hospital Motol, Institute of Biology and Medical Genetics, Laboratory of Assisted Reproduction and Reproductive Genetics, V Uvalu 84, Prague-5, 150 06, Czech Republic.
authors.forename: Marina
authors.initials: M
authors.lastname: Machatkova
authors.forename: Martina
authors.initials: M
authors.lastname: Brouckova
authors.forename: Milada
authors.initials: M
authors.lastname: Matejckova
authors.forename: Alice
authors.initials: A
authors.lastname: Krebsova
authors.forename: Karl
authors.initials: K
authors.lastname: Sperling
authors.forename: Svetlana
authors.initials: S
authors.lastname: Vorsanova
authors.forename: Sergei
authors.initials: S
authors.lastname: Kutsev
authors.forename: Tatiana
authors.initials: T
authors.lastname: Zerova
authors.forename: Svetlana
authors.initials: S
authors.lastname: Arbuzova
authors.forename: Roman
authors.initials: R
authors.lastname: Krejci
authors.forename: Michael
authors.initials: M
authors.lastname: Petersen
authors.forename: Milan
authors.initials: M
authors.lastname: Macek
mesh_terms: D004314:Down Syndrome / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005453:Fluorescence; D018392:Genomic Imprinting; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008540:Meiosis; D009630:Nondisjunction, Genetic; D010290:Parents; D016133:Polymerase Chain Reaction; D012426:Russia / Q000453:epidemiology; D014455:Ukraine / Q000453:epidemiology