Does aging affect the response of vitamin E status to vitamin E depletion and supplementation?
A vitamin E depletion/supplementation study was conducted in 100 healthy 20-75-year-old volunteers. The responses of vitamin E status to 3-week dietary vitamin E restriction to approximately 25% of recommended intake and 2-month unrestricted dietary intake plus 800 IU/d of RRR-alpha-tocopherol were studied as a function of age. Plasma alpha-tocopherol concentrations were closely related to cholesterol concentrations, which increased with age (P < 0.001). Upon dietary restriction, plasma alpha-tocopherol concentrations decreased significantly (P < 0.001) but independently of age. Plasma alpha-tocopherol responses to supplementation increased significantly with age, but this effect disappeared after standardization for cholesterol. gamma-Tocopherol concentrations decreased to less than 30% of baseline.
Winklhofer-Roob
Brigitte M
BM
Human Nutrition & Metabolism Research Training Center, Institute of Molecular Biosciences, Karl-Franzens University, Schubertstrasse 1, A-8010 Graz, Austria. brigitte.winklhoferroob@uni-graz.at
Roob
Johannes M
JM
Maritschnegg
Michaela
M
Sprinz
Grete
G
Hiller
Doris
D
Marktfelder
Elisabeth
E
Preinsberger
Melanie
M
Wuga
Sandra
S
Sundl
Isabella
I
Tiran
Beate
B
Cardinault
Nicolas
N
Ribalta
Josep
J
Rock
Edmond
E
D000328:Adult; D000368:Aged; D000375:Aging; D004032:Diet; D019587:Dietary Supplements; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D014810:Vitamin E / Q000008:administration & dosage*; D024502:alpha-Tocopherol / Q000008:administration & dosage* / Q000097:blood*
D014810:Vitamin E; D024502:alpha-Tocopherol