title: Management of excessive tearing as a side effect of docetaxel.
abstract: Docetaxel is a highly effective chemotherapeutic agent for metastatic or locally advanced breast cancer as well as other malignancies. One of the side effects of weekly administration of docetaxel is epiphora (excessive tearing) caused by canalicular stenosis and nasolacrimal duct obstruction. This article summarizes experience with epiphora and canalicular stenosis as a side effect of docetaxel and provides specific recommendations for management of this side effect.
authors.affiliation: Section of Ophthalmology, Department of Plastic Surgery, Unit 443, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. besmaeli@mdanderson.org
authors.forename: Bita
authors.initials: B
authors.lastname: Esmaeli
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D003231:Conjunctivitis / Q000139:chemically induced / Q000628:therapy; D003251:Constriction, Pathologic; D000077143:Docetaxel; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000139:chemically induced* / Q000628:therapy*; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel