Oxygen, oxidative stress, hypoxia, and heart failure.
A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular processes, consideration of its role in the heart is essential in understanding the pathogenesis of cardiac dysfunction.
Giordano
Frank J
FJ
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA. Frank.Giordano@yale.edu
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002303:Cardiac Output, Low / Q000473:pathology / Q000503:physiopathology*; D004734:Energy Metabolism; D005786:Gene Expression Regulation; D006801:Humans; D006984:Hypertrophy; D000860:Hypoxia / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism; D008055:Lipids / Q000633:toxicity; D008928:Mitochondria / Q000378:metabolism; D017202:Myocardial Ischemia / Q000378:metabolism; D009206:Myocardium / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D007473:Ion Channels; D008055:Lipids; D017382:Reactive Oxygen Species; D010100:Oxygen; D002118:Calcium