title: Repetitive transcranial magnetic stimulation induces kf-1 expression in the rat brain.
abstract: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive approach used for stimulating the brain, and has proven effective in the treatment of depression, however the mechanism of its antidepressant action is unknown. Recently, we have reported the induction of kf-1 in rat frontal cortex and hippocampus after chronic antidepressant treatment and repeated electroconvulsive treatment (ECT). In this study, we demonstrated the induction of kf-1 after rTMS in the rat frontal cortex and hippocampus, but not in hypothalamus. Our data suggest that kf-1 may be a common functional molecule that is increased after antidepressant treatment, ECT and rTMS. In conclusion, it is proposed that induction of kf-1 may be associated with the treatment induced adaptive neural plasticity in the brain, which is a long-term target for their antidepressant action.
authors.affiliation: Department of Psychiatry, Showa University School of Medicine, Tokyo 142-8666, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kudo
authors.forename: Misa
authors.initials: M
authors.lastname: Yamada
authors.forename: Kou
authors.initials: K
authors.lastname: Takahashi
authors.forename: Gentaro
authors.initials: G
authors.lastname: Nishioka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Tomo
authors.initials: T
authors.lastname: Hashiguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukuzako
authors.forename: Morikuni
authors.initials: M
authors.lastname: Takigawa
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Higuchi
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Momose
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Kamijima
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D015152:Blotting, Northern; D017931:DNA Primers; D005625:Frontal Lobe / Q000378:metabolism*; D015870:Gene Expression; D006220:Haloperidol / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000187:drug effects; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050781:Transcranial Magnetic Stimulation
chemical_list: D000928:Antidepressive Agents; D017931:DNA Primers; D009419:Nerve Tissue Proteins; C484500:Rnf103 protein, rat; D006220:Haloperidol