title: [Pharmaceutical agents for calcium-induced cell damage (Na+/Ca2+ exchange inhibitor)].
abstract: Recently, a novel selective inhibitor of the Ca(2+) influx mode of the Na(+)/Ca(2+) exchanger, KB-R7943, has been developed. This compound is expected to be a pharmaceutical agent that offers effective protection against ischemia/reperfusion-associated injury in several organs such as heart and kidney. Here, we summarize pharmacological profiles of KB-R7943, the molecular mechanism of its action, and its future prospect as a novel pharmaceutical agent.
authors.affiliation: Department of Molecular Physiology, National Cardiovascular Center Research Institute.
authors.forename: T
authors.initials: T
authors.lastname: Iwamoto
authors.forename: S
authors.initials: S
authors.lastname: Kita
authors.forename: M
authors.initials: M
authors.lastname: Shigekawa