Functional imaging of a large demyelinating lesion.
OBJECTIVE
To determine the metabolic characterization of a large solitary demyelinating lesion.


METHODS
Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies with 2-deoxy-2-[F-18]fluoro-d-glucose (FDG), carbon-11-methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating lesion.


RESULTS
The demyelinating lesion exhibited a low glucose uptake, prominent methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an increased choline to creatine (cho/cr) ratio and a decreased N-acetyl-aspartate to creatine (NAA/cr) ratio, which demonstrated a return to near normal ratios on follow-up study.


CONCLUSIONS
The report summarizes the metabolic characteristics of a demyelinating plaque.
Padma
M V
MV
Wallace-Kettering Neurosciences Institute, Wright State University, Kettering Medical Center, 45429 OH., USA. vasanthapadma123@rediffmail.com
Adineh
M
M
Pugar
K
K
Mukherjee
J
J
Satter
M
M
Shi
B
B
Dunigan
K
K
Bidwell
K
K
Ezzeddine
B
B
Mantil
J
J
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology; D003711:Demyelinating Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008715:Methionine; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D049268:Positron-Emission Tomography; D011859:Radiography
D019788:Fluorodeoxyglucose F18; C086242:carbon-11 methionine; D008715:Methionine