title: [Study on the variation of platelet function in pregnancy induced hypertension and gestational diabetes mellitus].
abstract: OBJECTIVE
  To investigate the platelet activity and function in pregnancy induced hypertension (PIH) and gestational diabetes mellitus (GDM).
  
  
  METHODS
  Twenty-one patients with GDM and 23 patients with PIH in third-trimester were included. Twenty normal pregnant women in third-trimester served as controls. Platelet count (PC), mean platelet volume (MPV) were determined on Cell-DYN 1600 and the expression of CD62P was analyzed on FACSC alibur.
  
  
  RESULTS
  (1) PC was (181 +/- 56) x 10(9)/L in PIH, (206 +/- 60) x 10(9)/L in GDM and (229 +/- 56) x 10(9)/L in controls, respectively. PC in PIH was lower than that of controls (P < 0.01), but there was no significant difference between GDM and controls. (2) MPV was (11.2 +/- 2.0) fl in PIH, significantly higher than that of controls (8.7 +/- 1.6) fl (P < 0.001). In GDM, MPV was (9.5 +/- 1.6) fl, without significant difference compared with that of controls. (3) The expression of CD62P increased significantly in PIH compared with controls [CD62P: (42 +/- 13)% vs (26 +/- 7)%, P < 0.001; CD62P(I): 109 +/- 39 vs 75 +/- 13, P < 0.01]. In GDM, the expression of CD62P also increased significantly compared with the normal pregnancy [CD62P(%): (42 +/- 14)% vs (26 +/- 7), P < 0.001; CD62P(I): 100 +/- 42 vs 75 +/- 13, P < 0.05]. (4) All parameters had no significant difference between PIH and GDM.
  
  
  CONCLUSIONS
  Platelet activity is enhanced in PIH and GDM. It may play an important role in the pathogenesis and development of the two diseases.
authors.affiliation: Department of Hematology, Second Affiliated Hospital, Zhongshan University, Guangzhou 510120, China.
authors.forename: Song-mei
authors.initials: SM
authors.lastname: Yin
authors.forename: Yi-qing
authors.initials: YQ
authors.lastname: Li
authors.forename: Shuang-feng
authors.initials: SF
authors.lastname: Xie
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Ma
authors.forename: Yu-dan
authors.initials: YD
authors.lastname: Wu
authors.forename: Da-nian
authors.initials: DN
authors.lastname: Nie
authors.forename: Jian-hong
authors.initials: JH
authors.lastname: Feng
authors.forename: Li-zhuo
authors.initials: LZ
authors.lastname: Xu
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D015539:Platelet Activation; D010976:Platelet Count; D010980:Platelet Membrane Glycoproteins / Q000096:biosynthesis; D011247:Pregnancy
chemical_list: D010980:Platelet Membrane Glycoproteins