Synthesis and in vitro pharmacological activity of oxypropanol analogs of labetalol.
New oxypropanol alpha- and beta-adrenoceptor blocking agents, analogs of labetalol, were synthesised and studied in vitro in left atria and aorta for alpha and beta activity.
Brizzi
Antonella
A
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Aldo Moro 6, 53100 Siena, Italy.
Brizzi
Vittorio
V
Valoti
Massimo
M
D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects; D006325:Heart Atria / Q000187:drug effects; D007741:Labetalol / Q000138:chemical synthesis* / Q000494:pharmacology; D020005:Propanols / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D020005:Propanols; D007741:Labetalol