[Close relationship between bone and vasculature].
Cardiovascular disease and osteoporosis are major causes of morbidity and mortality in elderly and postmenopausal women. Vascular calcification is a common feature of atherosclerotic plaques and is regulated in a way similar to bone mineralization. Several studies revealed that atherosclerotic calcification is associated with bone loss in women. In this review, we focus on the new developments during the past year in relationship between bone and vasculature. Regulatory factors include matrix GLA protein, osteoprotegerin, klotho gene, bisphosphonates and statins.
Jono
Shuichi
S
Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine.
Nishizawa
Yoshiki
Y