title: Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee.
abstract: Although reovirus infections are thought to be common in adults, there have been few assessments of the seroprevalence of reovirus in young children. We developed an indirect enzyme-linked immunosorbent assay to measure levels of total antireovirus immunoglobulin A, G, and M in serum specimens collected from otherwise healthy infants and children (1 month to 5 years of age) in Nashville, Tennessee. Of the 272 serum specimens evaluated, 64 (23.5%) tested positive for reovirus-specific antibodies. We observed an age-dependent increase in reovirus-specific antibodies in children 1 year of age and older, peaking at 50.0% in children 5-6 years of age. These findings suggest that reovirus infections are common during early childhood.
authors.affiliation: Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2581, USA.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Tai
authors.forename: John V
authors.initials: JV
authors.lastname: Williams
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Edwards
authors.forename: Peter F
authors.initials: PF
authors.lastname: Wright
authors.forename: James E
authors.initials: JE
authors.lastname: Crowe
authors.forename: Terence S
authors.initials: TS
authors.lastname: Dermody
mesh_terms: D017677:Age Distribution; D000375:Aging / Q000276:immunology; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology*; D000918:Antibody Specificity; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D030102:Orthoreovirus, Mammalian / Q000276:immunology*; D012088:Reoviridae Infections / Q000453:epidemiology / Q000276:immunology*; D013714:Tennessee / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral