Long-term follow-up in patients with Pendred syndrome: vestibular, auditory and other phenotypes.
Fourteen patients with a Pendred syndrome gene (Pds) mutation and three patients without the mutation were studied to evaluate long-term vestibular and auditory manifestations among patients with bilateral enlarged vestibular aqueducts (EVA). Charts were reviewed retrospectively for age, gender, otological history, presence or absence of vertigo, results of magnetic resonance imaging, relevant gene mutations and perchlorate discharge test. A missense mutation, His 723 Arg (H723R), was identified in the homozygous state in six patients and in the heterozygous state in seven patients. Another missense mutation, Tyr 410 Met (T410 M), was identified in the heterozygous state in one patient. Patients with vertigo tended to have hearing fluctuation, compared with the patients without vertigo. Patients homozygous for H723R tended to have more episodes of vertigo than the heterozygous individuals. Only one patient who was homozygous for H723R had goiter. The long-term outcome of hearing level in patients with the H723R mutation was significantly better compared with published results for patients with a Pds mutation, but not for those with the H723R mutation. Whether environmental factors or a subtype of the Pds mutation H723R are related to the long-term outcome for these patients must be clarified.
Sugiura
Makoto
M
Department of Otorhinolaryngology, Nagoya University School of Medicine, 466-8550 Nagoya, Japan. makotos@med.nagoya-u.ac.jp
Sato
Eisuke
E
Nakashima
Tsutomu
T
Sugiura
Junko
J
Furuhashi
Atsushi
A
Yoshino
Takahiko
T
Nakayama
Atsuo
A
Mori
Naoyoshi
N
Murakami
Hideki
H
Naganawa
Shinji
S
D000293:Adolescent; D000328:Adult; D001309:Auditory Threshold; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006042:Goiter / Q000235:genetics*; D006319:Hearing Loss, Sensorineural / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics*; D020125:Mutation, Missense; D009759:Nystagmus, Pathologic; D010641:Phenotype; D012189:Retrospective Studies; D000076988:Sulfate Transporters; D013577:Syndrome; D014717:Vertigo / Q000235:genetics*; D014723:Vestibular Aqueduct / Q000002:abnormalities*
D026901:Membrane Transport Proteins; C085609:SLC26A4 protein, human; D000076988:Sulfate Transporters