title: C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus.
abstract: Elevations in C-reactive protein (CRP) concentration are associated with an increased risk of future coronary events in prospective studies and it has been suggested that CRP could be used to aid risk prediction. A +1444C>T polymorphism in the CRP gene has been associated with differences in CRP concentration. We investigated the effect of this polymorphism on the CRP response to periodontal therapy, an intermediate inflammatory stimulus. Clinical parameters, CRP, and interleukin-6 (IL-6) concentrations were evaluated in 55 consecutive patients suffering from periodontitis at baseline, 1, 7 and 30 days after an intensive course of periodontal treatment. In a multivariate analysis individuals homozygous for the +1444T allele showed higher CRP concentrations (day 1, 21.10+/-4.81 mg/L and day 7, 4.89+/-0.74 mg/L) compared with C-allele carriers (day 1, 12.37+/-1.61 mg/L and day 7, 3.08+/-2.00 mg/L). This effect was independent of conventional cardiovascular risk factors and inflammatory factors known to affect CRP concentrations. CRP genotype may need to be considered when CRP values are used in coronary risk prediction.
authors.affiliation: Department of Periodontology and Eastman Clinical Investigation Center, Eastman Dental Institute and Hospital, 256 Gray's Inn Road, University College London (UCL), London WC1X 8LD, UK.
authors.forename: Francesco
authors.initials: F
authors.lastname: D'Aiuto
authors.forename: Juan P
authors.initials: JP
authors.lastname: Casas
authors.forename: Tina
authors.initials: T
authors.lastname: Shah
authors.forename: Steve E
authors.initials: SE
authors.lastname: Humphries
authors.forename: Aroon D
authors.initials: AD
authors.lastname: Hingorani
authors.forename: Maurizio S
authors.initials: MS
authors.lastname: Tonetti
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000235:genetics* / Q000494:pharmacology*; D005260:Female; D005838:Genotype; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D010517:Periodontics / Q000379:methods; D010518:Periodontitis / Q000628:therapy; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein