Erythrocytes, as well as microbubble contrast agents, are important factors in improving thermal and therapeutic effects of high-intensity focused ultrasound.
Erythrocytes, as well as microbubble contrast agents, are important factors in improving thermal effect of high-intensity focused ultrasound (US), or HIFU, and increasing the coagulation volume produced by HIFU irradiation. In vitro experiments used human plasma with various concentrations of human erythrocytes in combination with or without Levovist. In vivo experiments used eight Japan white rabbits with three degrees of anemia. Using a 2.17-MHz transducer, HIFU was applied for 60 s, and the temperature rise and the volume of coagulation necrosis was evaluated. There was a significant correlation between the HIFU-induced temperature rise and hematocrit, with a correlation coefficient of 0.998 (p=0.0001). Although the temperature rise was smaller at low hematocrit, it was significantly increased by adding Levovist in the suspension (p<0.01). The mean volume of coagulation necrosis was significantly greater in the rabbits with higher hematocrits (p<0.01), and that in the moderate anemia group was significantly increased by using Levovist (p<0.01).
Takegami
Kenji
K
Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan. ktakegami-tky@umin.ac.jp
Kaneko
Yukio
Y
Watanabe
Toshiaki
T
Maruyama
Toshiyuki
T
Matsumoto
Yoichiro
Y
Nagawa
Hirokazu
H
D000740:Anemia / Q000503:physiopathology; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D001831:Body Temperature / Q000187:drug effects; D003287:Contrast Media / Q000494:pharmacology*; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D006400:Hematocrit; D006358:Hot Temperature; D006801:Humans; D008099:Liver / Q000503:physiopathology; D045423:Microbubbles; D009336:Necrosis; D011134:Polysaccharides / Q000494:pharmacology*; D011817:Rabbits; D014464:Ultrasonic Therapy / Q000379:methods*
D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508