Temperature sensitive poly[N-isopropylacrylamide-co-(acryloyl beta-cyclodextrin)] for improved drug release.
The model drugs ibuprofen (IBU) and tegafur (T-Fu) were loaded into poly[N-isopropylacrylamide-co-(acryloyl beta-cyclodextrin)] [P(NIPA-co-A-CD)] and PNIPA hydrogels by immersing dried gels in IBU or T-Fu alcohol solutions until they reached equilibrium. Drug release studies were carried out in water at 25 degrees C. In contrast to the release time of conventional PNIPA hydrogel, that of IBU from the beta-CD incorporated hydrogel was significantly prolonged and the drug loading was also greatly increased, which may be the result of the formation of inclusion complexes between CD and ibuprofen. However, another hydrophilic drug, tegafur, did not display these properties because it could not form a complex with the CD groups. [diagram in text].
Zhang
Jian-Tao
JT
Key Laboratory of Biomedical Polymers (Wuhan University), Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.
Huang
Shi-Wen
SW
Liu
Ji
J
Zhuo
Ren-Xi
RX
D000180:Acrylic Resins / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry; D005641:Tegafur / Q000008:administration & dosage / Q000737:chemistry; D013696:Temperature
D000180:Acrylic Resins; D003505:Cyclodextrins; D003692:Delayed-Action Preparations; D020100:Hydrogels; C503431:poly(N-isopropylacrylamide-co-(acryloyl beta-cyclodextrin)); D005641:Tegafur; D007052:Ibuprofen