[High-dose radiation-induced meningioma following prophylactic cranial irradiation for acute lymphoblastic leukaemia].
A 12 year-old girl was treated with prophylatic cranial irradiation for acute lymphoblastic leukaemia (ALL). At the age of 39, she was admitted to our hospital for status epilepticus. Computed tomography demonstrated two, enhancing bilateral sided intracranial tumors. After surgery, this patient presented meningiomas which histologically, were of the meningothelial type. The high cure rate in childhood ALL, attributable to aggressive chemotherapy and prophylatic cranial irradiation, is capable of inducing secondary brain tumor. Twelve cases of high-dose radiation-induced meningioma following ALL are also reviewed.
Matsuda
Ryosuke
R
Department of Neurosurgery, National Hospital Organization Osaka Minami Medical Center. cak93500@pop02.odn.ne.jp
Nikaido
Yuji
Y
Yamada
Tomonori
T
Mishima
Hideaki
H
Tamaki
Ryo
R
D000328:Adult; D016543:Central Nervous System Neoplasms / Q000517:prevention & control; D016371:Cranial Irradiation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000209:etiology* / Q000601:surgery; D008579:Meningioma / Q000209:etiology* / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000601:surgery; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000532:radiotherapy*; D011879:Radiotherapy Dosage