title: Successful pregnancy, achieved by ovulation induction using a human menopausal gonadotropin low-dose step-up protocol in an infertile patient with Kallmann's syndrome.
abstract: A 25-year-old woman, diagnosed with Kallmann's syndrome and wanting to become pregnant, visited our hospital. Because her serum gonadotropin levels indicated hypogonadotropic hypogonadism, a main symptom of Kallmann's syndrome, we attempted to induce ovulation using a low-dose human menopausal gonadotropin (hMG) step-up protocol. In this protocol, 75 IU of hMG was used as an initial dose and this was continued for the first 14 days because adequate follicular development was not achieved. The dose of hMG was subsequently increased to 150 IU for the next 7 days. After 22 days from the start of stimulation, two follicles had developed, and were ovulated using an injection of human chorionic gonadotropin. She became pregnant, and her pregnancy was uneventful during the first trimester; however, in the second trimester both uterine contractions and blood pressure could not be controlled, and at 27 weeks' gestation she delivered a male infant weighing 830 g by cesarean section.
authors.affiliation: Division of Reproductive Medicine, Department of Perinatal Medicine and Maternal Care, National Center for Child Health and Development, Setagaya, Tokyo, Japan. nakagawa-kj@ncchd.go.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Wakako
authors.initials: W
authors.lastname: Iwasaki
authors.forename: Mami
authors.initials: M
authors.lastname: Sato
authors.forename: Megumu
authors.initials: M
authors.lastname: Ito
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawachiya
authors.forename: Atsuko
authors.initials: A
authors.lastname: Murashima
authors.forename: Michihiko
authors.initials: M
authors.lastname: Kitagawa
authors.forename: Michiya
authors.initials: M
authors.lastname: Natori
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Saito
mesh_terms: D000328:Adult; D002585:Cesarean Section; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D017436:Kallmann Syndrome / Q000150:complications*; D008297:Male; D008596:Menotropins / Q000008:administration & dosage*; D007752:Obstetric Labor, Premature; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy
chemical_list: D008596:Menotropins