Effect of the herbicide glyphosate on liver lipoperoxidation in pregnant rats and their fetuses.
Glyphosate is a post-emergence herbicide that acts on the synthesis of amino acids and other endogenous metabolites in plants. It is commonly used in agriculture, forestry, and nurseries for the control or destruction of herbaceous plants. Metabolic processes during development and pregnancy could be sensitive to changes induced by glyphosate such as lipid peroxidation. The present study has investigated the effects that 1% glyphosate oral exposure has on lipoperoxidation and antioxidant enzyme systems in the maternal serum and liver of pregnant rats and their term fetuses at 21 days of gestation. The results suggest that excessive lipid peroxidation induced with glyphosate ingestion leads to an overload of maternal and fetal antioxidant defense systems.
Beuret
Cecilia Judith
CJ
Cátedra de Bioquímica Molecular, Area Química Biológica, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700 San Luis, Argentina.
Zirulnik
Fanny
F
Giménez
María Sofía
MS
D000284:Administration, Oral; D000818:Animals; D002374:Catalase / Q000378:metabolism; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D020567:Fetal Weight / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000378:metabolism; D005998:Glycine / Q000031:analogs & derivatives* / Q000633:toxicity*; D006540:Herbicides / Q000633:toxicity*; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000196:embryology / Q000201:enzymology / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D000097797:Glyphosate
D002374:Catalase; D005979:Glutathione Peroxidase; D005998:Glycine; D006540:Herbicides; D013482:Superoxide Dismutase; D000097797:Glyphosate