title: Confirming positive results of nucleic acid amplification tests (NAATs) for Chlamydia trachomatis: all NAATs are not created equal.
abstract: The Centers for Disease Control and Prevention recommended confirming positive screening tests for Chlamydia trachomatis when positive predictive values are <90%. It is accepted that less sensitive tests (i.e., culture and immunoassays) should not be used to confirm the results of more sensitive nucleic acid amplification tests (NAATs). We show that the same principle applies when NAATs are used for confirmation.
authors.affiliation: Chlamydia Research Laboratory, Department of Laboratory Medicine, University of California-San Francisco, 1001 Potrero Ave., SFGH 3416, San Francisco, CA 94110, USA. jsch@itsa.ucsf.edu
authors.forename: J
authors.initials: J
authors.lastname: Schachter
authors.forename: E W
authors.initials: EW
authors.lastname: Hook
authors.forename: D H
authors.initials: DH
authors.lastname: Martin
authors.forename: D
authors.initials: D
authors.lastname: Willis
authors.forename: P
authors.initials: P
authors.lastname: Fine
authors.forename: D
authors.initials: D
authors.lastname: Fuller
authors.forename: J
authors.initials: J
authors.lastname: Jordan
authors.forename: W M
authors.initials: WM
authors.lastname: Janda
authors.forename: M
authors.initials: M
authors.lastname: Chernesky
mesh_terms: D002487:Centers for Disease Control and Prevention, U.S.; D002692:Chlamydia trachomatis / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D008297:Male; D021141:Nucleic Acid Amplification Techniques; D012680:Sensitivity and Specificity; D014481:United States