[Osteoporosis in rheumatoid arthritis: role of osteoclast differentiation and cytokines].
There has been accumulating evidence that osteoclasts, the primary cells responsible for bone resorption, are also involved in bone and joint destruction in rheumatoid arthritis (RA) . Recent progress in bone cell biology has revealed the molecular mechanism of osteoclast differentiation and bone resorption by mature osteoclasts. We here highlight the potential role of RANKL-RANK pathways in bone destruction in RA.
Tanaka
S
S
Department of Orthopaedic Surgery, Graduate School of Medicine, University of Tokyo.