SRprises along a messenger's journey.
SR (serine/arginine-rich) proteins were originally identified as essential splicing factors. Recent work, however, has implicated these proteins in numerous additional steps of mRNA metabolism, including nuclear export, RNA stability, mRNA quality control, and translation.
Huang
Yingqun
Y
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Steitz
Joan A
JA
D000818:Animals; D001120:Arginine / Q000737:chemistry*; D006801:Humans; D008954:Models, Biological; D029543:Nucleocytoplasmic Transport Proteins / Q000502:physiology*; D010766:Phosphorylation; D014176:Protein Biosynthesis; D017434:Protein Structure, Tertiary; D012322:RNA Precursors; D012326:RNA Splicing; D034443:RNA Transport; D012333:RNA, Messenger / Q000378:metabolism; D012694:Serine / Q000737:chemistry*
D029543:Nucleocytoplasmic Transport Proteins; D012322:RNA Precursors; D012333:RNA, Messenger; D012694:Serine; D001120:Arginine