title: Formation of core/shell nanoparticles with a lipid core and their application as a drug delivery system.
abstract: A novel preparation method for core/shell nanoparticles with a drug-loaded lipid core was designed and characterized. The lipid core is composed of lecithin and a drug, and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly (propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). For the formation of stabilized core/shell nanoparticles, freeze-drying was performed in the presence of trehalose used as a cryoprotectant. Cryogenic transmittance electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and a particle size analyzer were used to observe the formation of the stabilized core/shell nanoparticles. For the application of the core/shell nanoparticles as a drug carrier, paclitaxel, a potent anticancer drug, was loaded into the core/shell nanoparticles, and the drug loading amount and the drug release pattern were observed.
authors.affiliation: Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Ku, Taejeon, Korea 306-791.
authors.forename: Keun Sang
authors.initials: KS
authors.lastname: Oh
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Lee
authors.forename: Sung Sik
authors.initials: SS
authors.lastname: Han
authors.forename: Sun Hang
authors.initials: SH
authors.lastname: Cho
authors.forename: Dongmin
authors.initials: D
authors.lastname: Kim
authors.forename: Soon Hong
authors.initials: SH
authors.lastname: Yuk
mesh_terms: D002152:Calorimetry, Differential Scanning; D020285:Cryoelectron Microscopy; D004337:Drug Carriers; D004339:Drug Compounding; D005612:Freeze Drying; D008055:Lipids; D049329:Nanostructures; D017239:Paclitaxel / Q000008:administration & dosage; D010713:Phosphatidylcholines; D020442:Poloxamer
chemical_list: D004337:Drug Carriers; D008055:Lipids; D010713:Phosphatidylcholines; D020442:Poloxamer; D017239:Paclitaxel