Sitostanetriol is not formed in vivo from sitosterol in the rat.
In a recent study, we observed some oxyphytosterols in the plasma of healthy human subjects. This experiment was effected in order to determine if these compounds could be formed in vivo from phytosterols. Rats were fed with a high level of phytosterols (1% of the diet) and they were compared to rats deprived of phytosterols, using triglycerides purified from phytosterols. Their plasma were analysed for the main oxyphytosterols. The results show that sitostanetriol and campestanetriol were not formed in vivo from phytosterols. Their levels decreased during the experiment. The diet origin is highly probable for the compounds identified in human plasma. In particular, it seems that the sitostanetriol is eliminated very slowly from the organism.
Grandgirard
André
A
INRA, BP 86510, 21065 Dijon Cedex, France. andre.grandgirard@wanadoo.fr
Martine
Lucy
L
Juanéda
Pierre
P
Cordelet
Catherine
C
D000704:Analysis of Variance; D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D010084:Oxidation-Reduction; D010840:Phytosterols / Q000008:administration & dosage* / Q000378:metabolism* / Q000493:pharmacokinetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012855:Sitosterols / Q000378:metabolism*; D014280:Triglycerides / Q000008:administration & dosage / Q000378:metabolism
D010840:Phytosterols; D012855:Sitosterols; D014280:Triglycerides; C025473:gamma-sitosterol