title: An Ets element regulates the transcription of the human 2B4 gene in natural killer cells.
abstract: 2B4 (CD244) acts as an activation receptor on human NK cells, whereas it sends inhibitory signals in murine NK cells. A previous study indicated a prominent role for AP-1 in the transcription of 2B4 gene. To further understand the transcriptional regulation we analyzed the upstream positive regulatory region (-1151 to -704) of the 2B4 promoter. We have identified an Ets element that regulates the 2B4 gene transcription in an AP1 dependent manner.
authors.affiliation: Department of Molecular Biology and Immunology and Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
authors.forename: Swapnil V
authors.initials: SV
authors.lastname: Vaidya
authors.forename: Porunelloor A
authors.initials: PA
authors.lastname: Mathew
mesh_terms: D015703:Antigens, CD / Q000235:genetics*; D018983:DNA Footprinting; D003850:Deoxyribonuclease I / Q000378:metabolism; D024202:Electrophoretic Mobility Shift Assay; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology*; D008156:Luciferases; D008562:Membrane Glycoproteins / Q000235:genetics*; D016296:Mutagenesis; D009841:Oligonucleotides; D017434:Protein Structure, Tertiary / Q000235:genetics; D011971:Receptors, Immunologic / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D000071176:Signaling Lymphocytic Activation Molecule Family; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*
chemical_list: D015703:Antigens, CD; C084093:CD244 protein, human; D008562:Membrane Glycoproteins; D009841:Oligonucleotides; D011971:Receptors, Immunologic; D000071176:Signaling Lymphocytic Activation Molecule Family; D014157:Transcription Factors; D008156:Luciferases; D003850:Deoxyribonuclease I