[Therapeutic approaches to increased bone resorption].
The accelerated bone resorption contributes significantly to the pathophysiology of diseases such as osteoporosis, Paget's disease, hypercalcemia, bone metastasis, and inflammation of bone associated with rheumatoid arthritis. Several antiresorptive agents have been validated as a means to control bone resorption in these diseases. A recent understanding of the molecular mechanism of osteoclastic bone resorption is providing opportunities for developing novel antiresorptive agents.
Sone
Teruki
T
Department of Nuclear Medicine, Kawasaki Medical School.