title: Adenovirus type F subtype 41 causing disseminated disease following bone marrow transplantation for immunodeficiency.
abstract: Adenovirus causes disseminated disease following bone marrow transplantation (BMT). We report a child who underwent T-cell-depleted BMT. Adenovirus subgenus F serotype 41 was detected antemortem by PCR in cerebrospinal fluid and postmortem in other tissues. Serotypes 40 and 41, associated with gastrointestinal disease, have not previously been implicated in disseminated disease.
authors.affiliation: Paediatric Immunology Unit, Ward 23, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom.
authors.forename: Mary A
authors.initials: MA
authors.lastname: Slatter
authors.forename: Steven
authors.initials: S
authors.lastname: Read
authors.forename: Clive E
authors.initials: CE
authors.lastname: Taylor
authors.forename: Bruce N A
authors.initials: BN
authors.lastname: Crooks
authors.forename: Mario
authors.initials: M
authors.lastname: Abinun
authors.forename: Terence J
authors.initials: TJ
authors.lastname: Flood
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Cant
authors.forename: Christopher
authors.initials: C
authors.lastname: Wright
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Gennery
mesh_terms: D000258:Adenovirus Infections, Human / Q000209:etiology*; D000260:Adenoviruses, Human / Q000145:classification* / Q000302:isolation & purification; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D016133:Polymerase Chain Reaction; D016511:Severe Combined Immunodeficiency / Q000628:therapy*