title: Polytopic proteins: preventing aggregation in the membrane.
abstract: It has been proposed that the aggregation of nascent transmembrane segments of polytopic proteins is prevented by chaperones present in the endoplasmic reticulum membrane; now the first experimental support for this proposal has been reported.
authors.affiliation: Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: J Michael
authors.initials: JM
authors.lastname: Lord
authors.forename: Stephen
authors.initials: S
authors.lastname: High
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D008565:Membrane Proteins / Q000096:biosynthesis / Q000378:metabolism*; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D017510:Protein Folding; D017434:Protein Structure, Tertiary / Q000502:physiology; D000069816:SEC Translocation Channels
chemical_list: D002352:Carrier Proteins; D008565:Membrane Proteins; D018832:Molecular Chaperones; D000069816:SEC Translocation Channels