title: Mesalamine-induced lung injury in a patient with ulcerative colitis and a confounding autoimmune background: a case report.
abstract: Two years after being diagnosed with ulcerative colitis, a 57-year-old man taking oral mesalamine experienced severe respiratory distress due to left lung pleuropneumonitis. Eight months later, severe respiratory distress recurred due to right lung pneumonitis. Extraintestinal manifestations of inflammatory bowel disease or mesalamine-induced pulmonary injury were considered in the differential diagnosis, which was complicated by a history of aseptic meningitis and evidence of an ongoing autoimmune response. The implications of the case are discussed.
authors.affiliation: Department of Gastroenterology, Ospedale Molinette, Corso Bramante 88, 10126 Torino, Italy. actis_g@libero.it
authors.forename: Giovanni C
authors.initials: GC
authors.lastname: Actis
authors.forename: Antonio
authors.initials: A
authors.lastname: Ottobrelli
authors.forename: Sergio
authors.initials: S
authors.lastname: Baldi
authors.forename: Ermanno
authors.initials: E
authors.lastname: Scappaticci
authors.forename: Vittorio
authors.initials: V
authors.lastname: Modena
authors.forename: Enrico
authors.initials: E
authors.lastname: Fusaro
authors.forename: Giulio
authors.initials: G
authors.lastname: Mengozzi
authors.forename: Mario
authors.initials: M
authors.lastname: Rizzetto
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D019804:Mesalamine / Q000009:adverse effects*; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000139:chemically induced*; D013256:Steroids / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013256:Steroids; D019804:Mesalamine