Role of KATP channels in the regulation of rat dura and pia artery diameter.
The aim of the present study was to examine the effect of K(ATP) channel openers pinacidil and levcromakalim on rat dural and pial arteries as well as their inhibition by glibenclamide. We used an in-vivo genuine closed cranial window model and an in-vitro organ bath. Glibenclamide alone reduced the dural but not the pial artery diameter compared with controls. Intravenous pinacidil and levcromakalim induced dural and pial artery dilation that was significantly attenuated by glibenclamide. In the organ bath pinacidil and levcromakalim induced dural and middle cerebral artery relaxation that was significantly attenuated by glibenclamide. In conclusion, K(ATP) channel openers induce increasing diameter/relaxation of dural and pial arteries after intravenous infusion in vivo and on isolated arteries in vitro. Furthermore, dural arteries were more sensitive to K(ATP) channel openers than pial arteries.
Gozalov
A
A
Danish Headache Center and Department of Neurology, Glostrup University Hospital, DK-2600 Glostrup, Denmark. dragozalov@yahoo.com
Petersen
K A
KA
Mortensen
C
C
Jansen-Olesen
I
I
Klaerke
D
D
Olesen
J
J
D000818:Animals; D001158:Arteries / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D019806:Cromakalim / Q000494:pharmacology; D004388:Dura Mater / Q000098:blood supply* / Q000166:cytology / Q000187:drug effects; D005905:Glyburide / Q000494:pharmacology; D008297:Male; D010841:Pia Mater / Q000098:blood supply* / Q000166:cytology / Q000187:drug effects; D020110:Pinacidil / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology
D015221:Potassium Channels; D014665:Vasodilator Agents; D019806:Cromakalim; D020110:Pinacidil; D005905:Glyburide