Genetic polymorphism of CYP17 and breast cancer risk in Korean women.
CYP17 gene is involved in steroidogenesis and steroid metabolism. Epidemiologic results on the association between the CYP17 polymorphism and breast cancer risk have been inconsistent. We examined the association between the MspAI polymorphism at +27 relative to the start of transcription in the 5'-untranslated region of CYP17 gene and breast cancer risk in Korean women. Four hundred and sixty-two incident cases and 337 controls were recruited from three teaching hospitals in Seoul during 1994-2001. Polymorphism of the CYP17 gene was determined by a single base extension assay. Demographic and lifestyle characteristics were identified using structured questionnaire. Age-adjusted (aOR) and multivariate odds ratios (& mgr;OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression. The proportions of A1/A1, A1/A2 and A2/A2 genotypes among controls were 20.8%, 45.1% and 34.1%, respectively. Compared to the A1/A1 genotype, A1/A2 or A2/A2 genotype was not statistically significantly associated with overall breast cancer risk (i.e., mOR = 1.01, 95% CI = 0.69-1.47 and mOR = 0.76, 95% CI = 0.51-1.14, respectively). However, a significant association between CYP17 A2/A2 genotype and breast cancer was observed among women aged 50 years or less (mOR = 0.58, 95% CI = 0.34-0.99, P =0.04) and leaner women (body mass index < 22 kg/ m2) (mOR = 0.48, 95% CI = 0.23-0.97, P = 0.04). Our results suggest that genetic polymorphism in 5'-untranslated region of CYP17 might play a role in breast cancer development in Korean women among younger women aged less than 50 or leaner women with body mass index less than 22 kg/m2.
Shin
Myung-Hee
MH
Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, 300 Chunchun-dong, Jangan-gu, Suwon, Gyeongi-do 440-746, Korea.
Lee
Kyoung-Mu
KM
Yang
Jung-Hyun
JH
Nam
Seok Jin
SJ
Kim
Jong-Won
JW
Yoo
Keun-Young
KY
Park
Sue Kyung
SK
Noh
Dong-Young
DY
Ahn
Sei-Hyun
SH
Kim
Bongcheol
B
Kang
Daehee
D
D020121:5' Untranslated Regions / Q000235:genetics*; D001940:Breast / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*; D011795:Surveys and Questionnaires
D020121:5' Untranslated Regions; D013254:Steroid 17-alpha-Hydroxylase