title: Isolated hyperkalemia associated with cyclosporine administration in allogeneic stem cell transplantation for renal cell carcinoma.
abstract: Two patients with advanced renal cell carcinoma underwent allogeneic hematopoietic stem cell transplantation and received cyclosporine (CSP) as part of their immunosuppressive therapy. Despite adequate renal function, both patients developed hyperkalemia. CSP was the only pharmaceutical agent to which this electrolyte abnormality could be attributed. Evaluation of renal tubule function suggested that CSP-associated isolated hyperkalemia resulted from tubular resistance to aldosterone. We propose that the presence of a single functional kidney may be a risk factor for isolated hyperkalemia due to CSP.
authors.affiliation: Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan. takami@med3.m.kanazawa-u.ac.jp
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Takami
authors.forename: Hidesaku
authors.initials: H
authors.lastname: Asakura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takamatsu
authors.forename: Hirohito
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Masahisa
authors.initials: M
authors.lastname: Arahata
authors.forename: Tomoe
authors.initials: T
authors.lastname: Hayashi
authors.forename: Masami
authors.initials: M
authors.lastname: Shibayama
authors.forename: Michiko
authors.initials: M
authors.lastname: Orito
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Yoshida
authors.forename: Mikio
authors.initials: M
authors.lastname: Namiki
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000628:therapy; D016572:Cyclosporine / Q000009:adverse effects*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced*; D007684:Kidney Tubules / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous
chemical_list: D016572:Cyclosporine