title: Temporal bone density measurements using CT in otosclerosis.
abstract: OBJECTIVE
  To assess the bone density around the bony labyrinth in otosclerosis patients and to compare it to that of a control population.
  
  
  METHODS
  This was a prospective case-control study. Ten patients with otosclerosis (mean age 42 years; range 24-55 years) and 33 control patients with vestibular schwannoma (mean age 46 years; range 20-71 years) were included. All patients underwent a clinical examination, audiometry and a CT scan comprising axial and coronal views of both temporal bones. In the otosclerosis group, audiometry showed unilateral involvement in six patients and bilateral hearing loss in four. The bone density was measured at the fissula ante fenestram (FAF) and at five other anatomical points on the bony labyrinth.
  
  
  RESULTS
  In the control group, the bone density was similar at the six anatomical points. In the otosclerosis patients, the mean bone density at the FAF was lower than that in control patients (1649+/-99.1 vs 2049+/-13.4 HU; p < 0.01). For patients with FAF bone densities < 2000 HU, a correlation was observed between hearing threshold and FAF bone density.
  
  
  CONCLUSIONS
  FAF bone density appears to be a good indicator of disease progression, and could serve as a follow-up and prognostic parameter.
authors.affiliation: Otolaryngology Department, Hôpital Beaujon, AP-HP, Clichy, France. alexis.bozorg-grayeli@bjn.ap-hop-paris.fr
authors.forename: A Bozorg
authors.initials: AB
authors.lastname: Grayeli
authors.forename: C Saint
authors.initials: CS
authors.lastname: Yrieix
authors.forename: Y
authors.initials: Y
authors.lastname: Imauchi
authors.forename: F
authors.initials: F
authors.lastname: Cyna-Gorse
authors.forename: E
authors.initials: E
authors.lastname: Ferrary
authors.forename: O
authors.initials: O
authors.lastname: Sterkers
mesh_terms: D000328:Adult; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000000981:diagnostic imaging* / Q000473:pathology; D013701:Temporal Bone / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed