Genetics of left ventricular hypertrophy and its regression.
Genetics of left ventricularophy and its regression The importance of left ventricular hypertrophy (LVH) in hypertension is well established. The development of LVH results from the interaction of genetic, hemodynamic, neurohumoral and environmental factors. In this review we describe the principal genetic alterations of cardiac hypertrophy and the genetic polymorphisms that are most consistently related to its development and particularly to the therapeutic induction of regression. The identification of a particular genetic profile could, in the future, help to predict the regression of left ventricular hypertrophy in response to different antihypertensive drugs.
Nogueira
J Braz
JB
Medicina 1, Hospital de Santa Maria, Faculdade de Medicina de Lisboa, Portugal.
D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011945:Receptors, Angiotensin / Q000235:genetics; D012074:Remission Induction
D011945:Receptors, Angiotensin; D007703:Peptidyl-Dipeptidase A