Student screening for inherited blood disorders in Bahrain.
In Bahrain and neighbouring countries inherited disorders of haemoglobin, i.e. sickle-cell disease, thalassaemias and glucose-6-phosphate dehydrogenase (G6PD) deficiency, are common. As part of the National Student Screening Project to determine the prevalence of genetic blood disorders and raise awareness among young Bahrainis, we screened 11th-grade students from 38 schools (5685 students), organized lectures and distributed information about these disorders. Haemoglobin electrophoresis, high performance liquid chromatography, blood grouping and G6PD deficiency testing were performed. Prevalences were: 1.2% sickle-cell disease; 13.8% sickle-cell trait; 0.09% beta-thalassaemia; 2.9% beta-thalassaemia trait; 23.2% G6PD deficiency; 1.9% G6PD deficiency carrier. Health education, carrier screening and premarital counselling remain the best ways to reduce disease incidence with potentially significant financial savings and social and health benefits.
Al-Arrayed
S
S
Genetics Unit, Salmaniya Medical Complex, Manama, Bahrain.
Hafadh
N
N
Amin
S
S
Al-Mukhareq
H
H
Sanad
H
H
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control; D001445:Bahrain / Q000453:epidemiology; D003241:Consanguinity; D005260:Female; D006580:Genetic Carrier Screening; D005817:Genetic Counseling; D005820:Genetic Testing / Q000458:organization & administration*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control; D006266:Health Education; D006301:Health Services Needs and Demand; D006445:Hemoglobin C Disease / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control; D006446:Hemoglobin E; D006453:Hemoglobinopathies / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control; D006455:Hemoglobins, Abnormal; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D011159:Population Surveillance; D015995:Prevalence; D012572:School Health Services / Q000458:organization & administration*; D012805:Sickle Cell Trait / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control; D013789:Thalassemia / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control
D006455:Hemoglobins, Abnormal; C032001:hemoglobin D; D006446:Hemoglobin E