title: Multi-analyte procedures for screening for and quantification of drugs in blood, plasma, or serum by liquid chromatography-single stage or tandem mass spectrometry (LC-MS or LC-MS/MS) relevant to clinical and forensic toxicology.
abstract: This paper reviews multi-analyte procedures for screening and quantification of drugs in blood, plasma, or serum using liquid chromatography coupled with a single stage or tandem mass spectrometer (LC-MS, LC-MS/MS). These procedures are relevant tools in clinical and forensic toxicology, and cover analysis of amphetamines, cocaine, hallucinogens, opioids, anesthetics, hypnotics, benzodiazepines, antidepressants, neuroleptics, antihistamines, sulfonylurea-type antidiabetics, beta-blockers, and other cardiac drugs. Basic information on the procedures is given in two tables and multi-analyte screening, identification, and quantification are illustrated in three figures. A critical discussion on the pros and cons of such LC-MS procedures is also included.
authors.affiliation: Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany. hans.maurer@uniklinik-saarland.de
authors.forename: Hans H
authors.initials: HH
authors.lastname: Maurer
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods* / Q000706:statistics & numerical data; D005554:Forensic Medicine / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods* / Q000706:statistics & numerical data; D015999:Multivariate Analysis; D004364:Pharmaceutical Preparations / Q000097:blood*; D010949:Plasma / Q000737:chemistry; D012680:Sensitivity and Specificity; D044967:Serum / Q000737:chemistry; D013048:Specimen Handling; D014116:Toxicology / Q000379:methods
chemical_list: D004364:Pharmaceutical Preparations