title: Macrocyclic lactam synthesis via a ring expansion reaction: construction of the cripowellin skeleton.
abstract: [reaction: see text] The cripowellin ring skeleton, a macrocyclic [2.3.5]-bicyclic ketolactam, was smoothly generated via construction of a spiro(benzazepin-cyclohexane-1,3-dione) employing oxidative cyclization as a key step and a subsequent ring expansion reaction.
authors.affiliation: Department of Chemistry, Sogang University, Seoul 121-742, Korea. bjmoon@ccs.sogang.ac.kr
authors.forename: Bongjin
authors.initials: B
authors.lastname: Moon
authors.forename: Sangbae
authors.initials: S
authors.lastname: Han
authors.forename: Yeojin
authors.initials: Y
authors.lastname: Yoon
authors.forename: Hyejin
authors.initials: H
authors.lastname: Kwon
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007202:Indicators and Reagents; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D047151:Amaryllidaceae Alkaloids; D007202:Indicators and Reagents; D047029:Lactams, Macrocyclic; C506143:cripowellin A; C506144:cripowellin B