title: Axillary granular parakeratosis.
abstract: A 71-year-old man developed a pruritic axillary eruption. Histopathologic examination showed laminated orthokeratosis, parakeratosis, and hypergranulosis. There changes were consistent with a diagnosis of axillary granular parakeratosis. Axillary granular parakeratosis is an intertriginous eruption that is usually found in the axillae of middle-aged women and is characterized clinically by pruritic, erythematous, hyperkeratotic plaques and histologically by parakeratosis with retention of keratohyaline granules. Pathophysiology is thought to involve a defective profilaggrin-filaggrin pathway. Evidence-based treatment of this disorder is not available.
authors.affiliation: Ronald O. Perelman Department of Dermatology, New York University, USA.
authors.forename: Monika
authors.initials: M
authors.lastname: Srivastava
authors.forename: David
authors.initials: D
authors.lastname: Cohen
mesh_terms: D000368:Aged; D001365:Axilla; D000091344:Filaggrin Proteins; D006801:Humans; D008297:Male; D010241:Parakeratosis / Q000473:pathology*