Localization of brainstem auditory evoked potentials in primates: a comparison of localization techniques applied to deep brain sources.
The objective of this study was to evaluate the performance of source localization techniques through localization of deep brain sources. To accomplish this, two replications of a brainstem auditory evoked potential (BAEP, left ear 60 dB nHL clicks) were recorded from five normal rhesus monkeys. We analyzed waves III and IV, as this portion of the BAEP corresponds to the deepest signal. Data were analyzed using five different source localization techniques: Moving Dipoles, Fixed Dipoles, MUSIC (Multiple Signal Classification) dipole scan, LORETA (Low Resolution Tomography), and LCMV (Linearly Constrained Minimum Variance) spatial filtering. The moving dipole, fixed dipole and MUSIC solutions were found to be, on average, 25.1 mm from the brainstem generators. LORETA detected sources within the brainstem 65% of the time. However, 90% of these localization results also included false detections defined as regions of the brain that were more than 2 cm away from the auditory pathway. LCMV included the brainstem in 90% of the trials and false detections in 40% of the cases. These findings indicate that evoked electrical activity from deep brain sources can be localized with cm accuracy. The dipole methods performed better than LORETA and LCMV. Given the depth and amplitude of the sources analyzed in this study, these results can be interpreted as an upper bound on the accuracy of each technique.
Fontanarosa
Joel B
JB
Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA.
Lasky
Robert E
RE
Lee
Hyong C
HC
van Drongelen
Wim
W
D000161:Acoustic Stimulation / Q000379:methods; D000465:Algorithms; D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004566:Electrodes; D004569:Electroencephalography / Q000379:methods; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D014057:Tomography, X-Ray Computed / Q000379:methods