Mesalamine-induced lung injury in a patient with ulcerative colitis and a confounding autoimmune background: a case report.
Two years after being diagnosed with ulcerative colitis, a 57-year-old man taking oral mesalamine experienced severe respiratory distress due to left lung pleuropneumonitis. Eight months later, severe respiratory distress recurred due to right lung pneumonitis. Extraintestinal manifestations of inflammatory bowel disease or mesalamine-induced pulmonary injury were considered in the differential diagnosis, which was complicated by a history of aseptic meningitis and evidence of an ongoing autoimmune response. The implications of the case are discussed.
Actis
Giovanni C
GC
Department of Gastroenterology, Ospedale Molinette, Corso Bramante 88, 10126 Torino, Italy. actis_g@libero.it
Ottobrelli
Antonio
A
Baldi
Sergio
S
Scappaticci
Ermanno
E
Modena
Vittorio
V
Fusaro
Enrico
E
Mengozzi
Giulio
G
Rizzetto
Mario
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D019804:Mesalamine / Q000009:adverse effects*; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000139:chemically induced*; D013256:Steroids / Q000009:adverse effects / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013256:Steroids; D019804:Mesalamine