title: [Association of plasma homocysteine and cystathionine beta-synthase polymorphism with cerebral thrombosis].
abstract: OBJECTIVE
  To study the association of plasma homocysteine (Hcy) and polymorphism and cystathionine beta-synthase (CBS) with cerebral thrombosis.
  
  
  METHODS
  Eighty-seven patients with first-ever acute cerebral thrombosis and 80 control subjects were examined for plasma Hcy levels using high-performance liquid chromatography-fluorescence detection and for CBS polymorphism determined by amplification refractory mutation system.
  
  
  RESULTS
  The fasting plasma Hcy level was l5.28 micromol/L (95% CI 14.37-16.19 micromol/L) in the patient group, higher than that in the control group (11.32 micromol/L, 95% C1 10.47-12.16 micromol/L, P<0.001). Plasma Hcy levels varied with different genotypes. No difference in genotype or allele frequencies was noted between patient group and control group (P>0.05).
  
  
  CONCLUSIONS
  Common mutations in CBS G919A and CBS T833C lead to hyperhomocysteinemia, which, instead of common mutations in CBS, is more directly associated with increased risk of cerebral thrombosis.
authors.affiliation: Department of Neurology, First People's Hospital of Foshan City, Foshan 528000, China. shaoyan2001@21cn.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Shao
authors.forename: Cheng-Guo
authors.initials: CG
authors.lastname: Zhang
authors.forename: Jin-Huan
authors.initials: JH
authors.lastname: Cui
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003541:Cystathionine beta-Synthase / Q000097:blood* / Q000235:genetics; D005260:Female; D006710:Homocysteine / Q000097:blood* / Q000235:genetics; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D006710:Homocysteine; D003541:Cystathionine beta-Synthase