title: [Cushing's disease caused by pituitary macroadenoma].
abstract: Cushing's syndrome comprises the symptoms and signs associated with prolonged exposure to inappropriately elevated levels of free plasma glucocorticoids. When iatrogenic causes are excluded, the commonest cause of Cushing's syndrome is Cushing's disease, accounting for approximately 70% of cases. We present the case of a 20-year-old male patient with central obesity, moon face and purple-red striae, whose diagnostic investigation shows a pituitary macroadenoma. The patient was submitted to transsphenoidal hypophysectomy, but developed early recurrence. He was submitted to a second transsphenoidal intervention followed by pituitary radiation. Presently, the patient is in clinical and laboratory remission.
authors.affiliation: Divisão de Endocrinologia, Departamento de Clínica Médica, Hospital dos Servidores do Estado, Rio de Janeiro, RJ. rubatino@medico.zzn.com
authors.forename: Antônio C
authors.initials: AC
authors.lastname: Rubatino
authors.forename: Rodrigo Ferreira
authors.initials: RF
authors.lastname: Pereira
authors.forename: Isaac
authors.initials: I
authors.lastname: Benchimol
authors.forename: Ingeborg Christa
authors.initials: IC
authors.lastname: Laun
mesh_terms: D000236:Adenoma / Q000150:complications*; D000328:Adult; D006801:Humans; D008297:Male; D047748:Pituitary ACTH Hypersecretion / Q000209:etiology*; D010911:Pituitary Neoplasms / Q000150:complications*