[Drug therapy for osteoporosis associated with reumatoid arthritis (bisphosphonates)].
Rheumatoid arthritis (RA) causes local and systemic bone loss due the increased bone resorption. Because the bisphosphonates are potent inhibitors for bone resorption, these drugs will be the major regimen to treat RA-associated osteoporosis. In addition, some reports suggest that bisphosphonates may modulate the pathogenesis of RA itself. Further study of bisphosphonates may help improve the treatment of RA.
Hosoi
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Endocrinology Section, Tokyo Metropolitan Geriatric Center.