Quantitative drug levels in stimulant psychosis: relationship to symptom severity, catecholamines and hyperkinesia.
To examine the relationship between quantitative stimulant drug levels, catecholamines, and psychotic symptoms, nineteen patients in a psychiatric emergency service with a diagnosis of amphetamine- or cocaine-induced psychosis were interviewed, and plasma and urine were collected for quantitative assays of stimulant drug and catecholamine metabolite levels. Methamphetamine or amphetamine levels were related to several psychopathology scores and the global hyperkinesia rating. HVA levels were related to global hyperkinesia but not to psychopathology ratings. Although many other factors such as sensitization may play a role, intensity of stimulant-induced psychotic symptoms and stereotypies appears to be at least in part dose-related.
Batki
Steven L
SL
Department of Psychiatry, State University of New York (SUNY) Upstate Medical University and Syracuse VA Medical Center, Syracuse, NY, USA.
Harris
Debra S
DS
D000293:Adolescent; D000328:Adult; D000661:Amphetamine / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D002395:Catecholamines / Q000032:analysis*; D000697:Central Nervous System Stimulants / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D003042:Cocaine / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D018765:Dopamine Uptake Inhibitors / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D011569:Psychiatric Status Rating Scales; D011605:Psychoses, Substance-Induced / Q000503:physiopathology*; D012720:Severity of Illness Index
D002395:Catecholamines; D000697:Central Nervous System Stimulants; D018765:Dopamine Uptake Inhibitors; D008694:Methamphetamine; D000661:Amphetamine; D003042:Cocaine