[The serotoninergic division of the vegetative nervous system under normal and pathological conditions].
The authors researched into the mechanisms through which the sympathetic nerve intensifies the vagal stimulation of the gastroduodenal, urinary bladder, uterine and deferent duct motility and the vagal inhibition of heart functioning. It was shown that these phenomena are mediated by preganglionic serotoninergic fibers conducting excitement to intramural serotoninergic neurons. The study found a growing cranio-caudal gradient of the serotoninergic innervation of visceral organs. The mechanism of gastroduodenal motility activation includes intramural serotoninergic neurons, which conduct excitement to 5-HT1,2 -serotonin receptors of the effector tissues. A model of myocarditis and experimental gastric ulcer demonstrated the cardio- and gastroduodenoprotectory effects of the serotonin blockers.
Lychkova
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D000818:Animals; D004195:Disease Models, Animal; D004386:Duodenum / Q000294:innervation; D005260:Female; D006321:Heart / Q000294:innervation; D008297:Male; D009205:Myocarditis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D051381:Rats; D044263:Receptors, Serotonin, 5-HT1 / Q000378:metabolism; D044348:Receptors, Serotonin, 5-HT2 / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000627:therapeutic use; D013270:Stomach / Q000294:innervation; D013276:Stomach Ulcer / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D001743:Urinary Bladder / Q000294:innervation; D014599:Uterus / Q000294:innervation; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology; D014649:Vas Deferens / Q000294:innervation
D044263:Receptors, Serotonin, 5-HT1; D044348:Receptors, Serotonin, 5-HT2; D012702:Serotonin Antagonists; D012701:Serotonin