title: Constant light desynchronizes mammalian clock neurons.
abstract: Circadian organization can be disrupted by constant light, resulting in behavioral arrhythmicity or 'splitting' of rhythms of activity and rest. By imaging molecular rhythms of individual clock neurons in explanted mouse clock nuclei, we now find that constant light desynchronizes clock neurons but does not compromise their ability to generate circadian rhythms. Cellular synchrony within clock nuclei is disrupted during arrhythmicity, whereas neurons in the left and right clock nuclei cycle in antiphase during 'splitting.'
authors.affiliation: Department of Biological Sciences, Vanderbilt University, VU Station B, Box 35-1634, Nashville, Tennessee 37235-1634, USA.
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Ohta
authors.forename: Shin
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Douglas G
authors.initials: DG
authors.lastname: McMahon
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001683:Biological Clocks / Q000502:physiology* / Q000528:radiation effects; D002452:Cell Count / Q000379:methods; D016009:Chi-Square Distribution; D002940:Circadian Rhythm / Q000502:physiology*; D046508:Culture Techniques / Q000379:methods; D003952:Diagnostic Imaging / Q000379:methods; D005136:Eye Proteins / Q000235:genetics; D007839:Functional Laterality; D005786:Gene Expression Regulation / Q000528:radiation effects; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D008027:Light; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity / Q000502:physiology / Q000528:radiation effects; D009474:Neurons / Q000502:physiology / Q000528:radiation effects*; D056950:Period Circadian Proteins; D013493:Suprachiasmatic Nucleus / Q000166:cytology* / Q000502:physiology; D013997:Time Factors
chemical_list: D005136:Eye Proteins; C539023:Per1 protein, mouse; D056950:Period Circadian Proteins; D049452:Green Fluorescent Proteins