A case of mucoepidermoid carcinoma with melanin pigmentation manifested in the palate.
This paper describes the first documented case of mucoepidermoid carcinoma (MEC) with melanin pigmentation manifested in the palate. Histopathological sections showed a neoplasm composed of epidermoid, mucous-producing and intermediate cells. Numerous large cells contained dark pigmented materials. Fontana Masson staining revealed dendritic melanocytes and melanin granules. HMB-45, Melan A and S-100 protein were all positive for melanocytes. Histopathological examination was not typical for malignant melanoma; the lesion was diagnosed as a low-grade MEC with melanin pigmentation.
Sekine
Joji
J
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. georges@net.nagasaki-u.ac.jp
Anami
Masanobu
M
Fujita
Shuichi
S
Vieth
Michael
M
Inokuchi
Tsugio
T
D000328:Adult; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000378:metabolism; D018277:Carcinoma, Mucoepidermoid / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D058965:MART-1 Antigen; D008543:Melanins / Q000378:metabolism*; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology; D008545:Melanoma / Q000175:diagnosis; D058950:Melanoma-Specific Antigens; D008548:Melanosis / Q000473:pathology*; D009363:Neoplasm Proteins / Q000378:metabolism; D010157:Palatal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism; D012470:Salivary Glands, Minor / Q000378:metabolism / Q000473:pathology
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D008543:Melanins; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D009418:S100 Proteins