title: Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population.
abstract: We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2',5'-oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p=0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p=0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.
authors.affiliation: Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Hamano
authors.forename: Minako
authors.initials: M
authors.lastname: Hijikata
authors.forename: Satoru
authors.initials: S
authors.lastname: Itoyama
authors.forename: Tran
authors.initials: T
authors.lastname: Quy
authors.forename: Nguyen Chi
authors.initials: NC
authors.lastname: Phi
authors.forename: Hoang Thuy
authors.initials: HT
authors.lastname: Long
authors.forename: Le Dang
authors.initials: LD
authors.lastname: Ha
authors.forename: Vo Van
authors.initials: VV
authors.lastname: Ban
authors.forename: Ikumi
authors.initials: I
authors.lastname: Matsushita
authors.forename: Hideki
authors.initials: H
authors.lastname: Yanai
authors.forename: Fumiko
authors.initials: F
authors.lastname: Kirikae
authors.forename: Teruo
authors.initials: T
authors.lastname: Kirikae
authors.forename: Tadatoshi
authors.initials: T
authors.lastname: Kuratsuji
authors.forename: Takehiko
authors.initials: T
authors.lastname: Sasazuki
authors.forename: Naoto
authors.initials: N
authors.lastname: Keicho
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D064547:Myxovirus Resistance Proteins; D011110:Polymorphism, Genetic / Q000235:genetics*; D045169:Severe Acute Respiratory Syndrome / Q000235:genetics*; D014744:Vietnam
chemical_list: C579071:MX1 protein, human; D064547:Myxovirus Resistance Proteins; C475085:OAS1 protein, human; D015088:2',5'-Oligoadenylate Synthetase; D019204:GTP-Binding Proteins