The teratology of autism.
Autism spectrum disorders affect behaviors that emerge at ages when typically developing children become increasingly social and communicative, but many lines of evidence suggest that the underlying alterations in the brain occur long before the period when symptoms become obvious. Studies of the behavior of children in the first year of life demonstrate that symptoms are often detectable in the first 6 months. The environmental factors known to increase the risk of autism have critical periods of action during embryogenesis. Minor malformations that occur frequently in people with autism are known to arise in the same stages of development. Anomalies reported from histological studies of the brain are consistent with an early alteration of development. Congenital syndromes with high rates of autism include somatic that originate early in the first trimester. In addition, it is possible to duplicate a number of anatomic and behavioral features characteristic of human cases by exposing rat embryos to a teratogenic dose of valproic acid at the time of neural tube closure.
Arndt
Tara L
TL
Department of Obstetrics and Gynecology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Stodgell
Christopher J
CJ
Rodier
Patricia M
PM
D000818:Animals; D001321:Autistic Disorder / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D009445:Neuroanatomy / Q000379:methods; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors; D013723:Teratogens; D018600:Teratology; D014635:Valproic Acid / Q000633:toxicity
D013723:Teratogens; D014635:Valproic Acid