Spinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammation.
Spinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These data suggest that the central nervous systems of neonates and adults respond differently to peripheral noxious inputs, a fact that should be considered when selecting pain treatment strategies for neonate populations.
Zhang
Rui-Xin
RX
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA. Rzhan@umaryland.edu
Liu
Bing
B
Lao
Lixing
L
Qiao
Jian-Tian
JT
Ruda
M A
MA
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects; D015152:Blotting, Northern; D004399:Dynorphins / Q000096:biosynthesis*; D004591:Electrophoresis, Polyacrylamide Gel; D007249:Inflammation / Q000378:metabolism*; D011498:Protein Precursors / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013116:Spinal Cord / Q000378:metabolism*; D015854:Up-Regulation / Q000235:genetics
D011498:Protein Precursors; D012333:RNA, Messenger; C036448:pre-prodynorphin; D004399:Dynorphins