Adenovirus-based genetic vaccines for biodefense.
The robust host responses elicited against transgenes encoded by (E1-)(E3-) adenovirus (Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents and why Ad vectors are ideal as anti-bioterror vaccine platforms, providing examples from our laboratories of using Ad vectors as vaccines against potential bioterror pathogens and how Ad vectors can be developed to enhance vaccine efficacy in the bioterror war.
Boyer
Julie L
JL
Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.
Kobinger
Gary
G
Wilson
James M
JM
Crystal
Ronald G
RG
D016915:AIDS Vaccines; D000256:Adenoviridae / Q000235:genetics*; D023482:Bioterrorism; D003140:Communicable Disease Control; D015316:Genetic Therapy; D005822:Genetic Vectors; D015658:HIV Infections / Q000235:genetics / Q000628:therapy*; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
D016915:AIDS Vaccines; D014764:Viral Proteins