title: [Clinical study of bronchiolitis obliterans organizing pneumonia (BOOP) primed by radiation for breast cancer].
abstract: Bronchiolitis obliterans organizing pneumonia (BOOP) primed by radiation therapy for the breast cancer (BOOP-RT/BC) has been recognized recently. In this study, we reported 9 such cases and discussed steroid therapy. Mean radiation dose and interval from completion of radiation therapy to the appearance of BOOP-RT/BC were 47.3 Gy and 5.6 months respectively. BOOP-RT/BC recurrence was observed by 5 episodes in 3 of 9 cases (recurrence rate was 33%). Steroid therapy showed a remarkable improvement in both primary and recurrent disease, and no residual symptom or BOOP shadow was detectable at the end of the observation except for shadows due to radiation fibrosis. All but one patient were prescribed prednisolone, with a mean initial dose of 32.5 mg/day and a mean treatment duration of 46.7 weeks. One patient improved without treatment. No case suffered from respiratory failure which needed mechanical ventilation or was motile. Considering these findings and the fact that almost all patients are middle aged or senior women who are susceptible to osteoporosis, we conclude that steroid therapy for BOOP-RT/BC should be carefully considered.
authors.affiliation: Department of Internal Medicine and Thoracic Surgery, Haibara General Hospital.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ozawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Ida
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
authors.forename: Masato
authors.initials: M
authors.lastname: Fujii
authors.forename: Masato
authors.initials: M
authors.lastname: Kato
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Enomoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nogimura
authors.forename: Kingo
authors.initials: K
authors.lastname: Chida
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects; D001943:Breast Neoplasms / Q000532:radiotherapy*; D018549:Cryptogenic Organizing Pneumonia / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D020551:Pulse Therapy, Drug; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone; D008775:Methylprednisolone