[Evaluation of LDL susceptibility of patients with type 1 diabetes to in vitro oxidation and its relation to glycemic control].
In 38 patients with type 1 diabetes (DM 1) and 24 non-diabetics we investigated LDL susceptibility to in vitro oxidation. Fast and post-prandial glycaemia (PPG), glycated hemoglobin (HbA1c) and lipid profile were determined, together with an spectrophotometric analysis of LDL oxidation before and 1, 3, 6 and 24 hours after addition of the oxidant substance - copper sulphate (CuSO4). The LDL oxidation coefficient in the two groups presented similar basal values; however 3 hours after CuSO4, LDL was more oxidized in patients with DM1. There was a negative correlation with PPG (r= -0.2511; p<0.05) and HbA1c (r= -0.2541; p<0.05). We conclude that in our sample of DM patients LDL was oxidized earlier than in the non-diabetics and that the glycemic control is important in this event.
Castro
Simone H de
SH
Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ. simone_hc@ig.com.br
Castro-Faria-Neto
Hugo C
HC
Clemente
Eliete L S
EL
Gomes
Marília B
MB
D000328:Adult; D001786:Blood Glucose; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000628:therapy; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction
D001786:Blood Glucose; D008077:Lipoproteins, LDL