title: [Cushing disease resistent to conventional therapy: role of bilateral laparoscopic adrenalectomy].
abstract: Cushing's disease is the most frequent form of endogenous hypercortisolism in the adult. It is a rare disease, whose natural history is not well known, and has a tremendous impact on patients' quality of life. Trans-sphenoidal surgery is the first therapeutic option in the management of these patients, but it is associated with a 25% long-term recurrence rate. Based on the observation of two patients, the Authors discuss the multidisciplinary approach, the indications and the timing of treatment by bilateral adrenalectomy. Also, the peculiar aspects of the laparoscopic surgical technique are outlined.
authors.affiliation: Università degli Studi di Milano, Dipartimento di Scienze Medico-Chirurgiche, Unità Operativa di Endocrinologia, Istituto Policlinico San Donato.
authors.forename: Chiara
authors.initials: C
authors.lastname: Dall'Asta
authors.forename: Medhanie
authors.initials: M
authors.lastname: Abraham
authors.forename: Davide
authors.initials: D
authors.lastname: Bona
authors.forename: Bruno
authors.initials: B
authors.lastname: Ambrosi
authors.forename: Luigi
authors.initials: L
authors.lastname: Bonavina
mesh_terms: D000293:Adolescent; D000315:Adrenalectomy; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D047748:Pituitary ACTH Hypersecretion / Q000175:diagnosis / Q000601:surgery*; D012008:Recurrence; D013997:Time Factors