title: Factors involved in the regulation of plasma leptin levels in children and adolescents with anorexia nervosa.
abstract: OBJECTIVE
  The effects of changes in body mass index (BMI) and other factors on plasma leptin levels in children and adolescents with anorexia nervosa (AN) were examined.
  
  
  METHODS
  Plasma leptin levels and BMI was measured before and after initiation of refeeding therapy every 2 weeks for 8 weeks in 12 children and adolescents with AN. The plasma levels of insulin, cortisol, insulin-like growth factor-I (IGF-I), and tumor necrosis factor-alpha (TNF-alpha) were also measured in these subjects before and after 8 weeks of the refeeding therapy, and the results were compared with those from 12 age-matched healthy girls.
  
  
  RESULTS
  The plasma leptin and IGF-I levels, as well as the BMI, in the AN patients before refeeding therapy were significantly lower than both of these indices in the AN patients 8 weeks after initiation of the therapy and in the controls. The plasma leptin levels and BMI in the AN patients 8 weeks after initiation of the therapy were still significantly lower than those in the controls. Significant correlations between the plasma leptin levels and BMI were detected in the AN patients both before and 8 weeks after initiation of the refeeding therapy, as well as in the controls. The BMI showed a significant increase beginning at 2 weeks after initiation of the therapy compared with that before refeeding, but the plasma leptin levels did not significantly increase until 4 weeks after the initiation of therapy.
  
  
  CONCLUSIONS
  The results suggest that plasma leptin levels reflect changes in body fat content in children and adolescents with AN, although there is a delay in the recovery of plasma leptin levels compared with those of BMI in the early period of refeeding therapy, which is probably regulated by other factors.
authors.affiliation: Department of Pediatrics, Juntendo University School of Medicine, Tokyo 113-0033, Japan. tsimizut@aol.com
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shimizu
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Satoh
authors.forename: Noritsugu
authors.initials: N
authors.lastname: Kaneko
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Suzuki
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Lee
authors.forename: Kyoko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Megumi
authors.initials: M
authors.lastname: Iijima
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamashiro
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood*; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D020738:Leptin / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D007328:Insulin; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha; D007334:Insulin-Like Growth Factor I; D006854:Hydrocortisone