title: [The systems principle in establishing the allowable human daily dose of pesticides].
abstract: Instead of the earlier isolated standardization of the levels of pesticides in the foodstuffs, water, air, a comprehensive hygienic regulation of pesticides in the environmental objects, which is based on the criterion--an allowable daily dose (ADD)--has been implemented since 1967. The systems principle is used, by taking into account the toxicological and hygienic parameters and the adverse reactions. Tens of thousands of regulations have been legally adopted. ADD has been shown to be the basis for constructing a comprehensive system of regulation of pesticides, including the "expectation time", "the time of going to work", etc. The principles of harmonization of ADDs adopted by the WHO and Ukraine are presented.
authors.forename: N G
authors.initials: NG
authors.lastname: Prodanchuk
authors.forename: E I
authors.initials: EI
authors.lastname: Spynu
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Chaĭka
mesh_terms: D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000009:adverse effects / Q000592:standards / Q000633:toxicity*; D006801:Humans; D007928:Lethal Dose 50; D008452:Maximum Allowable Concentration; D010575:Pesticides / Q000009:adverse effects / Q000592:standards / Q000633:toxicity*; D013997:Time Factors; D014455:Ukraine; D014944:World Health Organization
chemical_list: D004785:Environmental Pollutants; D010575:Pesticides