title: Ocular manifestations in patients with microscopic polyangiitis.
abstract: OBJECTIVE
  To describe ocular manifestations in patients with microscopic polyangiitis.
  
  
  METHODS
  Two patients with microscopic polyangiitis complained of ocular symptoms and underwent ophthalmologic examinations.
  
  
  RESULTS
  An 83-year-old woman (Case 1) was diagnosed with microscopic polyangiitis, according to the general clinical findings and the presence of perinuclear pattern of antineutrophil cytoplasmic antibodies (P-ANCA). She had hypopyon iridocyclitis in the right eye and retinal cotton-wool spots in the left eye. The patient was treated with oral prednisolone and subconjunctival betamethasone. The hypopyon iridocyclitis and retinal cotton-wool spots responded. A 79-year-old man (Case 2) had bilateral scleritis. The diagnosis of microscopic polyangiitis was made based on general clinical findings and the presence of P-ANCA. Scleritis was reduced after corticosteroid treatment.
  
  
  CONCLUSIONS
  Ophthalmologists should be aware that hypopyon iridocyclitis, cotton-wool spot, and scleritis could occur in patients with microscopic polyangiitis.
authors.affiliation: Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama - Japan. ophthal@ms.toyama-mpu.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Mihara
authors.forename: S
authors.initials: S
authors.lastname: Hayasaka
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Kitagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Hayasaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000869:Anterior Eye Segment / Q000187:drug effects / Q000473:pathology*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D001623:Betamethasone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015863:Iridocyclitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012164:Retinal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D015423:Scleritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013492:Suppuration
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D005938:Glucocorticoids; D001623:Betamethasone; D011239:Prednisolone