title: Antinociceptive diterpene from Euphorbia decipiens.
abstract: One myrsinol-type diterpene ester (1) isolated from Euphorbia decipiens was evaluated for analgesic activity in the acetic acid induced writhing test in mice. Different dose (5-20 mg/kg i.p.) of the compound showed significant antinociceptive activity, which was comparable to standard analgesic drugs, aspirin and ibuprofen (100 mg/kg i.p.).
authors.affiliation: HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Viqar Uddin
authors.initials: VU
authors.lastname: Ahmad
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Ishfaq A
authors.initials: IA
authors.lastname: Bukhari
authors.forename: Javid
authors.initials: J
authors.lastname: Hussain
authors.forename: Amir Reza
authors.initials: AR
authors.lastname: Jassbi
authors.forename: Ahsana
authors.initials: A
authors.lastname: Dar
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D028481:Euphorbia; D005260:Female; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D004224:Diterpenes; D010936:Plant Extracts; D019342:Acetic Acid