title: Adipose tissue is a regulated source of interleukin-10.
abstract: White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra. We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase).
authors.affiliation: Laboratory of Molecular Endocrinology, Department of Medicine, Geneva Medical School, rue Michel Servet 1, CH-1211 Geneva 4, Switzerland.
authors.forename: Cristiana E
authors.initials: CE
authors.lastname: Juge-Aubry
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Somm
authors.forename: Agnès
authors.initials: A
authors.lastname: Pernin
authors.forename: Navid
authors.initials: N
authors.lastname: Alizadeh
authors.forename: Vittorio
authors.initials: V
authors.lastname: Giusti
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Dayer
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Meier
mesh_terms: D000273:Adipose Tissue / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000235:genetics / Q000276:immunology*; D012333:RNA, Messenger / Q000096:biosynthesis
chemical_list: D012333:RNA, Messenger; D016753:Interleukin-10