title: Biphasic decline of CD4 cell count during scheduled treatment interruptions.
abstract: In 115 patients whose scheduled treatment interruptions (STI) lasted 24 weeks, the CD4 cell count declined by a median of 30 cells/ml/week during the first 4 weeks, compared with 3 cells/ml/week during the next 20 weeks. In multivariate regression, a pronounced early fall in CD4 cells correlated with a higher CD4 cell count at the start of STI, with more gain in CD4 cells during antiretroviral treatment preceding STI, and with a higher viral load at week 4.
authors.affiliation: University Hospital, Geneva, Switzerland, and the Swiss HIV Cohort Study.
authors.forename: Catherine
authors.initials: C
authors.lastname: Fagard
authors.forename: Cédric Y
authors.initials: CY
authors.lastname: Bandelier
authors.forename: Jintanat
authors.initials: J
authors.lastname: Ananworanich
authors.forename: Michelle
authors.initials: M
authors.lastname: Le Braz
authors.forename: Huldrych
authors.initials: H
authors.lastname: Günthard
authors.forename: Thomas
authors.initials: T
authors.lastname: Perneger
authors.forename: Felipe
authors.initials: F
authors.lastname: García
authors.forename: Bernard
authors.initials: B
authors.lastname: Hirschel
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D018791:CD4 Lymphocyte Count; D004334:Drug Administration Schedule; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D006801:Humans; D011446:Prospective Studies; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents