[The pathophysiology of adynamic bone disease].
Adynamic bone disease was first noted in the early 1980s. It now represents the predominant bone lesion in peritoneal dialysis patients and is nearly as prevalent as osteitis fibrosis in hemodialysis patients. Bone turnover is markedly reduced in this disorder but, A in contrast to osteomalacia, there is no increase in osteoid formation. Although the pathophysiology of adynamic bone disease is still obscure, skeletal resistance to the calcemic action of PTH is important factor. Recently several study, whose reveal the down regulation of PTH receptor, osteoclast inhibitory factor and a assay of PTH, whole PTH play a role on the pathophysiology of skeletal resistance, were reported.
Yokoyama
K
K
Division of Nephrology and Hypertension, Tokyo Jikei University School of Medicine.
Shigematsu
T
T
Ogura
Y
Y