title: [Importance of routine mediastinal staging in women with non-small cell lung cancer].
abstract: OBJECTIVE
  To study the specific importance of mediastinal staging in women with nonsmall cell lung cancer.
  
  
  METHODS
  Between July 1981 and September 2003 we surgically staged 2172 patients with nonsmall cell lung cancer who met the inclusion criteria for resectability and operability. A subgroup of 108 women was studied. Cervical mediastinoscopy was performed in all cases, with the addition of anterior mediastinotomy in cases with left upper lobe involvement. All patients underwent a preoperative computed tomography chest scan.
  
  
  RESULTS
  Cervical mediastinoscopy was performed on all 108 patients, 26 of whom also underwent anterior mediastinotomy. Positive findings were recorded in 44 (40.7%) of the 108 cases: 39 of the 108 mediastinoscopies (36.1%), 9 of the 26 mediastinotomies (34.6%), and in 5 cases (19.2%) both mediastinoscopy and mediastinotomy. Nodal involvement was found in 13% of cases in clinical stage IA and 30.8% of cases in clinical stage IB. The percentage of positive findings was significantly higher for cases with adenocarcinoma or large cell carcinoma (P<.05). We performed 67 thoracotomies: 46 patients underwent lobectomy (42.6% of the 108), 7 bilobectomy (6.5%), 9 pneumonectomy (8.3%), and 5 exploratory thoracotomy (4.6%). The agreement between clinical staging after mediastinoscopy and pathological staging after thoracotomy was 47% (stage IA) and 57% (stage IB).
  
  
  CONCLUSIONS
  Routine mediastinoscopy is indicated for all women with nonsmall cell lung cancer, regardless of clinical stage.
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario 12 de Octubre, Madrid, España.
authors.forename: Jl
authors.initials: J
authors.lastname: Martín de Nicolás
authors.forename: A
authors.initials: A
authors.lastname: Gómez-Caro Andrés
authors.forename: F J
authors.initials: FJ
authors.lastname: Moradiellos Díez
authors.forename: V
authors.initials: V
authors.lastname: Díaz-Hellín
authors.forename: O
authors.initials: O
authors.lastname: Gigirey Castro
authors.forename: E
authors.initials: E
authors.lastname: Larrú Cabrero
authors.forename: J A
authors.initials: JA
authors.lastname: Pérez Antón
authors.forename: C
authors.initials: C
authors.lastname: Marrón Fernández
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D018287:Carcinoma, Large Cell / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D016009:Chi-Square Distribution; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008481:Mediastinoscopy; D009367:Neoplasm Staging; D011013:Pneumonectomy; D013902:Radiography, Thoracic; D012737:Sex Factors; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed