title: Thermoregulatory model for prediction of long-term cold exposure.
abstract: A multi-segmental mathematical model has been developed for predicting shivering and thermoregulatory responses during long-term cold exposure. The present model incorporates new knowledge on shivering thermogenesis, including the control and maximal limits of its intensity, inhibition due to a low core temperature, and prediction of endurance time. The model also takes into account individual characteristics of age, height, weight, % body fat, and maximum aerobic capacity. The model was validated against three different cold conditions i.e. water immersion up to 38 h and air exposure. The predictions were found to be in good agreement with the observations.
authors.affiliation: Biophysics and Biomedical Modeling Division, US Army Research Institute of Environmental Medicine, Kansas Street, Natick MA01760, USA. xiaojiang.xu@na.amedd.army.mil
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Xu
authors.forename: Peter
authors.initials: P
authors.lastname: Tikuisis
authors.forename: Richard
authors.initials: R
authors.lastname: Gonzalez
authors.forename: Gordon
authors.initials: G
authors.lastname: Giesbrecht
mesh_terms: D000328:Adult; D000388:Air; D001481:Basal Metabolism; D001833:Body Temperature Regulation; D003080:Cold Temperature; D005260:Female; D006801:Humans; D007101:Immersion; D008297:Male; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000098:blood supply; D012039:Regional Blood Flow; D012768:Shivering; D012881:Skin Temperature