Optic neuropathy associated with linezolid treatment.
Two patients undergoing long-term treatment with linezolid for pneumonia had decreased visual acuity, dyschromatopsia, and cecocentral scotomas characteristic of toxic optic neuropathy. Visual function slowly recovered 3 to 4 months after discontinuation of the antibiotic treatment in both patients. Toxic optic neuropathy may occur from linezolid. Early withdrawal of the antibiotic may be associated with visual recovery.
McKinley
Steven H
SH
Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.
Foroozan
Rod
R
D000081:Acetamides / Q000009:adverse effects*; D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects*; D005074:Evoked Potentials, Visual; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D000069349:Linezolid; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D023303:Oxazolidinones / Q000009:adverse effects*; D014792:Visual Acuity; D014794:Visual Fields
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid