Incorporation of oxyphytosterols in tissues of hamster.
Oxyphytosterols (OPS) were fed to hamsters, at different concentrations, in order to observe their eventual incorporation into plasma, aorta, liver, kidneys and heart. The animals receiving the very high level (2500 ppm) presented 7beta-hydroxycampesterol, beta-epoxycampesterol, campestanetriol, 7-ketocampesterol, 7beta-hydroxysitosterol, beta-epoxysitosterol, sitostanetriol and 7-ketositosterol in all tissues. The same compounds were observed in the tissues of animals receiving 500 ppm of OPS in their diet, but with much lower levels. In hamsters fed 100 ppm of OPS, as well as in control animals, in most cases, the only observed OPS was sitostanetriol, which seems to be difficult to eliminate from the animal.
Grandgirard
André
A
INRA, BP 86510, 21065 Dijon Cedex, France. andre.grandgirard@wanadoo.fr
Demaison-Meloche
Joëlle
J
Cordelet
Catherine
C
Demaison
Luc
L
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D002855:Chromatography, Thin Layer / Q000379:methods; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008647:Mesocricetus; D009206:Myocardium / Q000378:metabolism*; D009928:Organ Specificity; D010084:Oxidation-Reduction; D010840:Phytosterols / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D011897:Random Allocation; D014018:Tissue Distribution
D010840:Phytosterols