title: Brugada syndrome: 12 years of progression.
abstract: Brugada syndrome is increasingly being recognized in clinical medicine. What started as an electrocardiographic curiosity has become an important focus of attention for individuals working in the different disciplines related to sudden cardiac death, from basic scientists to clinical cardiac electrophysiologists. In just 12 years, since the description of the disease, clinically relevant information is continuously being provided to physicians to help protect the individuals with Brugada syndrome to the best of our ability. And this information has been gathered thanks to the effort of hundreds of basic scientists, physicians and patients who continue to give their time, effort and data to help understand how the electrocardiographic pattern may cause sudden cardiac death. There are still many unanswered questions, both at the clinical and basic field. However, with the further collection of data, the longer follow-up and the continued interest from the basic science world we will have the necessary tools to the successful unraveling of the disease.
authors.affiliation: Masonic Medical Research Laboratory, Utica, NY 13501, USA.
authors.forename: Kui
authors.initials: K
authors.lastname: Hong
authors.forename: Charles
authors.initials: C
authors.lastname: Antzelevitch
authors.forename: Pedro
authors.initials: P
authors.lastname: Brugada
authors.forename: Josep
authors.initials: J
authors.lastname: Brugada
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohe
authors.forename: Ramon
authors.initials: R
authors.lastname: Brugada
mesh_terms: D001145:Arrhythmias, Cardiac / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D004562:Electrocardiography; D005260:Female; D006331:Heart Diseases / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D062554:NAV1.5 Voltage-Gated Sodium Channel; D015222:Sodium Channels / Q000235:genetics / Q000378:metabolism; D013577:Syndrome
chemical_list: D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D015222:Sodium Channels