[Change of the endocrine function of the pancreas in patients with chronic pancreatitis].
There was a study of 19 chronic pancreatitis patients (10 male and 9 female), 11 chronic pancreatitis and pancreatogenic diabetes mellitus patients (8 male and 3 female) and 12 type 2 diabetes mellitus patients (4 male and 8 female) at the age of 30-60 as well as 15 control group subjects at the same age range. The content of the C-peptide and such peptides as INCINE, PAMG-cine and PAMG-tin in the blood serum was subjected to the immunoradiometric assay. It was discovered that there is a trend to the increased C-peptide level in CP patients while the C-peptide level in CP patients with diabetes mellitus was smaller than that in the control group; the C-peptide level in CP patients with type 2 diabetes mellitus was higher as compared to that in the control group. It was shown that erythrocytes of CP patients are less sensitive to insulin action and do not respond to the presence of insulinomimetic peptides under examination during the glucose uptake test. CP patients with diabetes mellitus and type 2 diabetes mellitus patients are more sensitive to the action of insulin and peptides applied. Synthetic insulinomimetic peptides can serve as a means for discovering the functional cell deficiency under the glucose uptake test.
Vinokurova
L V
LV
Astaf'eva
O V
OV
Tagirova
A K
AK
Terent'ev
A A
AA
D000328:Adult; D002096:C-Peptide / Q000097:blood*; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000209:etiology*; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005947:Glucose / Q000378:metabolism; D000071816:Glycodelin; D006023:Glycoproteins / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000150:complications*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D011257:Pregnancy Proteins / Q000737:chemistry / Q000494:pharmacology
D002096:C-Peptide; D000071816:Glycodelin; D006023:Glycoproteins; D007328:Insulin; C045246:PAEP protein, human; D010455:Peptides; D011257:Pregnancy Proteins; D005947:Glucose