title: Rosiglitazone is a safe and effective treatment option of new-onset diabetes mellitus after renal transplantation.
abstract: The purpose of this study was to assess the safety and efficacy of the insulin sensitizer rosiglitazone in patients with new-onset diabetes mellitus (NODM) after renal transplantation. Twenty-two patients with NODM after renal transplantation were selected to receive rosiglitazone therapy. All patients received prednisone, 15 patients were treated with tacrolimus and seven patients received cyclosporine A. For 16 of the 22 patients treatment with rosiglitazone therapy was successful and mean fasting blood glucose decreased from 182 +/- 17 to 127 +/- 7 mg/dl. Six patients were not treated successfully with rosiglitazone alone, one patient needed a second oral antidiabetic agent and four patients insulin therapy. In one patient rosiglitazone was stopped because of edema after 5 days. There were no changes either in serum creatinine concentrations, or cyclosporine and tacrolimus blood levels respectively. Treatment with rosiglitazone appears to be safe and effective in patients with NODM after renal transplantation.
authors.affiliation: Department of Nephrology, University Hospital Essen, Germany. frank.pietruck@uni-essen.de
authors.forename: Frank
authors.initials: F
authors.lastname: Pietruck
authors.forename: Andreas
authors.initials: A
authors.lastname: Kribben
authors.forename: Truyen Ngo
authors.initials: TN
authors.lastname: Van
authors.forename: Daniel
authors.initials: D
authors.lastname: Patschan
authors.forename: Stephan
authors.initials: S
authors.lastname: Herget-Rosenthal
authors.forename: Onno
authors.initials: O
authors.lastname: Janssen
authors.forename: Klaus
authors.initials: K
authors.lastname: Mann
authors.forename: Thomas
authors.initials: T
authors.lastname: Philipp
authors.forename: Oliver
authors.initials: O
authors.lastname: Witzke
mesh_terms: D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000209:etiology*; D004487:Edema / Q000139:chemically induced; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone