[General pharmacology of Danhong injection].
OBJECTIVE
To investigate the effect of Danhong injection on the cardiovascular, the respiratory, and the nervous systems in animals.


METHODS
Using the pressure transducer, tension transducer and subcutaneous electrodes connected to a multifunctional signal processor, the femoral artery pressure, respiratory curve and electrocardiogram were recorded, respectively, in dogs before and after administration of Danhong injection. The effect of the injection on spontaneous activities was observed in mice using a multifunctional mouse activity recorder. The effects were also observed on coordinated movements by recording tilt-board falling times of the mice and on hypnosis induced by subthreshold dose of pentobarbital sodium by observing the disappearance of righting reflex.


RESULTS
Danhong injection caused slight decrease in systolic blood pressure without obviously affecting the heart rate, diastolic blood pressure and respiratory system of anesthetized dogs 30 min after intravenous Danhong injection at the dose of 2.4 g/kg, but at the doses of 1.2 and 0.6 g/kg.b.w, the injection did not produce any significant impact. The coordinated movement and spontaneous activity and pentobarbital sodium-induced hypnosis in mice were not obviously affected by the 3 doses of Danhong injection.


CONCLUSIONS
Danhong injection does not affect the respiratory functions of the dogs and nervous system of mouse with the exception of the systolic pressure at the 3 doses.
Tai
Ming-Hui
MH
Department of Pharmacology, Southern Medical University, Guangzhou 510515, China.
Liu
Lan-Mei
LM
Ma
Ren-Qiang
RQ
Li
Xue
X
Pang
Jian-Xin
JX
Xu
Jiang-Ping
JP
D000818:Animals; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007267:Injections; D008297:Male; D051379:Mice; D011897:Random Allocation; D027561:Salvia miltiorrhiza
D004365:Drugs, Chinese Herbal