title: Atrial fibrillation device therapy considerations in design of clinical trials.
abstract: Management of atrial fibrillation is largely driven by the clinical status of the affected patient. Advances in understanding the mechanism of the arrhythmia have led to more aggressive catheter-based approaches to the management of atrial fibrillation. Because atrial fibrillation is a complex disease with multiple possible mechanisms, one approach for all patients is not feasible. Considerations regarding trial design and patient selection are discussed in this paper.
authors.affiliation: Department of Medicine, Division of Cardiology, George Washington University Medical Center, 2150 Pennsylvania Avenue NW, Washington, DC 20037, USA.
authors.forename: Murat
authors.initials: M
authors.lastname: Celebi
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Tracy
mesh_terms: D001281:Atrial Fibrillation / Q000453:epidemiology / Q000628:therapy*; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods*; D002986:Clinical Trials as Topic / Q000379:methods*; D023381:Endpoint Determination; D006801:Humans; D018579:Patient Selection; D012107:Research Design