title: Nano-scaled hydroxyapatite/polymer composite III. Coating of sintered hydroxyapatite particles on poly(4-methacryloyloxyethyl trimellitate anhydride)-grafted silk fibroin fibers.
abstract: A novel composite coupling between nano-scaled hydroxyapatite (HAp) particles and poly[4-methacryloyloxyethyl trimellitate anhydride (4-META)]-grafted silk fibroin (SF) through ionic interaction was synthesized. The weight gain of poly(4-META) by graft-polymerization increased with increasing the reaction time, eventually reaching a plateau value of about 20 wt%. The HAp nano-particles were adsorbed equally and dispersively on the treated SF fiber surface. The HAp content in the composite was 4.554 wt% +/- 0.098 (n = 4), confirmed by thermogravimetry (TG). This synthetic system requires no heat to connect HAp to SF and is useful when applying to non-heat-resistant polymers. The L-929 cell-adhesion test shows that the HAp/SF composite improves bioactivity compared to the original SF.
authors.affiliation: Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
authors.forename: Arata
authors.initials: A
authors.lastname: Korematsu
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Furuzono
authors.forename: Shoji
authors.initials: S
authors.lastname: Yasuda
authors.forename: Junzo
authors.initials: J
authors.lastname: Tanaka
authors.forename: Akio
authors.initials: A
authors.lastname: Kishida
mesh_terms: D020099:Coated Materials, Biocompatible / Q000032:analysis / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D017886:Durapatite / Q000737:chemistry*; D005349:Fibroins / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure*; D006358:Hot Temperature; D008422:Materials Testing; D008689:Methacrylates / Q000032:analysis / Q000737:chemistry*; D049329:Nanostructures / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D008689:Methacrylates; C482288:fibroin, silkworm; C034139:4-methacryloxyethyltrimellitic acid anhydride; D005349:Fibroins; D017886:Durapatite