title: Management of erosive lichen planus with topical tacrolimus and recurrence secondary to metoprolol.
abstract: Metoprolol, a widely prescribed beta-adrenergic receptor blocker, has occasionally been associated with a diversity of cutaneous reactions. We present a 79-year-old male patient with erosive lichen planus (LP) on the feet and hands who was successfully treated with topical tacrolimus. Six months after the lesions had been cured the patient received the beta-receptor blocker metoprolol for the treatment of hypertonus. Within only 2 weeks of metoprolol intake the erosive lesions on the palms and feet recurred. After discontinuation of the drug and repetitive topical treatment with tacrolimus a complete remission of the lesions could be achieved. The recurrence of erosive LP probably secondary to metoprolol and the therapeutic success of topical tacrolimus in the treatment of LP are discussed.
authors.affiliation: Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Meyer
authors.forename: T
authors.initials: T
authors.lastname: Burgdorff
authors.forename: R M
authors.initials: RM
authors.lastname: Szeimies
authors.forename: T
authors.initials: T
authors.lastname: Vogt
authors.forename: M
authors.initials: M
authors.lastname: Landthaler
authors.forename: S
authors.initials: S
authors.lastname: Karrer
mesh_terms: D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000368:Aged; D005533:Foot Dermatoses / Q000139:chemically induced* / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008010:Lichen Planus / Q000139:chemically induced* / Q000188:drug therapy*; D008297:Male; D008790:Metoprolol / Q000009:adverse effects*; D016559:Tacrolimus / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D007166:Immunosuppressive Agents; D008790:Metoprolol; D016559:Tacrolimus