[The intracellular signal transduction systems of PTH and its effects on bone resorption and formation].
PTH binds to PTH/PTHrP receptor, one of seventh transmembrane receptor, which activates cAMP/PKA system through Gs protein and causes an activation of PKC and an elevation of cytosolic calcium through Gq protein. PTH affects bone cells through these dual second messenger signaling systems(cAMP/PKA and Ca/PKC system). Recent studies revealed that PTH stimulates bone resorption as well as bone formation mainly through cAMP/PKA system. Further work is necessary to clarify the downstream of the signal, such as CREB and AP-1.
Kaji
Hiroshi
H
Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine.
Sugimoto
Toshitugu
T