title: Absence of human papillomavirus in esophageal carcinomas from southwestern Kenya.
abstract: Esophageal squamous cell cancer is highly prevalent in south-western Kenya. The role of human papillomavirus (HPV) in esophageal cancers from this region was evaluated. Biopsies of 29 esophageal squamous cell cancers were assayed for HPV DNA sequences by reverse line blot polymerase chain reaction, using 27 HPV type-specific probes. Viral sequences were found in none of the specimens. These results suggest the HPV is unlikely to be an etiologic factor for esophageal squamous cell cancers in this region.
authors.affiliation: Department of Surgery, Tenwek Hospital, Bomet, Kenya. Russ.White@wgm.org
authors.forename: R E
authors.initials: RE
authors.lastname: White
authors.forename: C
authors.initials: C
authors.lastname: Mungatana
authors.forename: G
authors.initials: G
authors.lastname: Mutuma
authors.forename: M E
authors.initials: ME
authors.lastname: Robert
authors.forename: R W
authors.initials: RW
authors.lastname: Daniel
authors.forename: M D
authors.initials: MD
authors.lastname: Topazian
authors.forename: K V
authors.initials: KV
authors.lastname: Shah
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000302:isolation & purification*; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000209:etiology*; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D007630:Kenya; D008297:Male; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000175:diagnosis / Q000209:etiology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications*; D016133:Polymerase Chain Reaction; D011446:Prospective Studies
chemical_list: D004279:DNA, Viral