[Mechanism of bone destruction in rheumatoid arthritis].
Osteoclasts play a critical role in bone destruction in rheumatoid arthritis. Activation of osteoclastogenesis is mediated by the enhanced expression of RANKL (receptor activator of NF-kappaB ligand), accompanied by reduced expression of its inhibitor, IFN-gamma. Accumulating evidence indicates that the osteoclast-targeted therapy is effective in arthritis models, suggesting a promising new strategy for rheumatoid bone destruction.
Takayanagi
Hiroshi
H
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo PRESTO, JST.