title: Air-stable Ir-(P-Phos) complex for highly enantioselective hydrogenation of quinolines and their immobilization in poly(ethylene glycol) dimethyl ether (DMPEG).
abstract: An air-stable catalyst system Ir-(P-Phos) catalyst was found to be highly effective in the asymmetric hydrogenation of quinoline derivatives. The catalyst immobilized in DMPEG was efficiently recovered and reused eight times, retaining reactivity and enantioselectivity.
authors.affiliation: Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Hong Kong, P.R. China.
authors.forename: Lijin
authors.initials: L
authors.lastname: Xu
authors.forename: Kim Hung
authors.initials: KH
authors.lastname: Lam
authors.forename: Jianxin
authors.initials: J
authors.lastname: Ji
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Fan
authors.forename: Wai-Hung
authors.initials: WH
authors.lastname: Lo
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan
mesh_terms: D000388:Air; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D017976:Phosphorus Acids / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C484978:(S)-ethyl 4,4-dimethyl pyroglutamate; D010720:Phosphines; D017976:Phosphorus Acids; D011804:Quinolines; D011092:Polyethylene Glycols; D007495:Iridium; C037219:quinoline; D011761:Pyrrolidonecarboxylic Acid