title: Virus reactivation and intravenous immunoglobulin (IVIG) therapy of drug-induced hypersensitivity syndrome.
abstract: Drug-induced hypersensitivity syndrome (DIHS) is a severe multi-organ system reaction caused by specific drugs. Many reports have revealed that human herpesvirus 6 (HHV-6) reactivation contributes to the development of DIHS. In addition, recent articles have shown that reactivation of other herpesviruses such as human herpesvirus 7 (HHV-7), Epstein-Barr virus (EBV), cytomegalovirus (CMV) might be also implicated in the development of DIHS. These observations suggest that not only HHV-6 but also other herpesvirses might reactivate from the latency and play an important role in the appearance of clinical manifestations of DIHS. Several patients with DIHS were treated with intravenous immunoglobulin (IVIG) in addition to systemic corticosteroids. The results have been encouraging although virus reactivation could not be suppressed. Although the pathomechanism of IVIG treatment in patients with DIHS remains unknown, the therapeutic effects of IVIG could be dependent, in part, on functional capabilities of anti-virus IgG contained in IVIG.
authors.affiliation: Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo 181-8611, Japan. kano@kyorin-u.ac.jp
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kano
authors.forename: Miyuki
authors.initials: M
authors.lastname: Inaoka
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sakuma
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shiohara
mesh_terms: D004342:Drug Hypersensitivity / Q000628:therapy* / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000276:immunology; D016199:Herpesvirus 7, Human / Q000276:immunology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D019349:Roseolovirus Infections / Q000150:complications / Q000276:immunology; D014777:Virus Diseases / Q000150:complications* / Q000276:immunology
chemical_list: D016756:Immunoglobulins, Intravenous