title: [Combination therapy of micafungin and itraconazole for a case of pulmonary aspergillosis].
abstract: The patient was a 73-year-old female who visited a physician with a chief complaint of fever, and was diagnosed with pneumonia. Ampicillin/sulbactam was administered, but ineffective, and the patient was referred to our hospital. In addition to severe inflammatory findings, cavity lesions were observed in the right upper lobe on plain chest X-ray and thoracic CT. Since Aspergillus fumigatus was cultured in bronchoalveolar lavage, a definite diagnosis of pulmonary aspergillosis was made. Intravenous administration of micafungin was initiated, but severe inflammatory findings persisted, and infiltrative shadows rapidly expanded. Oral itraconazole was concomitantly administered, and clinical symptoms and findings slowly improved. The plasma trough levels of micafungin, itraconazole, and hydroxyitraconazole were higher than the minimal inhibitory concentrations for the etiologic fungus, A. fumigatus, throughout the treatment period. No adverse events of the concomitant treatment were observed. Combination of the two antifungal agents may be effective for intractable pulmonary aspergillosis.
authors.affiliation: Department of Internal Medicine, Kinan General Hospital.
authors.forename: Takaya
authors.initials: T
authors.lastname: Maruyama
authors.forename: Takehiro
authors.initials: T
authors.lastname: Takagi
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Yuda
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000097:blood; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D054714:Echinocandins; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D017964:Itraconazole / Q000008:administration & dosage* / Q000097:blood; D055666:Lipopeptides; D008074:Lipoproteins / Q000008:administration & dosage* / Q000097:blood; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D000077551:Micafungin; D010456:Peptides, Cyclic / Q000008:administration & dosage* / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D017964:Itraconazole; D000077551:Micafungin