Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells.
In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl-hydroxychromans metabolites (CEHCs). The extent of this metabolism and the inhibitory effect on cell growth followed the order of magnitude alpha-T<alpha-T3<gamma-T<gamma-T3. The partial inhibition of gamma-T3 metabolism by ketoconazole did not influence cell proliferation. These early findings may suggest that the transformation of vitamin E to CEHC is mostly a detoxification mechanism useful to maintain the malignant properties of prostate cancer cells.
Conte
Carmela
C
University of Perugia, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, Via del Giochetto, 06126 Perugia, Italy. f.galli@unipg.it
Floridi
Alessandro
A
Aisa
Cristina
C
Piroddi
Marta
M
Floridi
Ardesio
A
Galli
Francesco
F
D002455:Cell Division / Q000187:drug effects*; D002839:Chromans / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology*
D002839:Chromans; C483420:carboxyethyl-hydroxychroman; D014810:Vitamin E; C013649:plastochromanol 8; D007654:Ketoconazole