title: [Intra uterine insemination with processed sperm for HIV serodiscordant couples in whom the man is HIV positive].
abstract: The desire to have children is more and more common in HIV serodiscordant couples. The Academic Medical Centre Amsterdam has developed a new treatment protocol for couples in whom the man is HIV positive. Semen is processed to obtain HIV-1 free spermatozoa. These spermatozoa are used for IUI treatment. Thus far, 20 serodiscordant couples underwent 76 IUI cycles. An insemination was performed in 50 cycles (66%). The insemination was cancelled in 26 cycles, because of too many follicles (risk for multiple pregnancy), weekend (no possibilities for virological testing), not enough spermatazoa after preparation, a positive HIV-1 RNA test and other reasons. 10 out of 20 women became pregnant (50%), 8 women were on-going pregnant. The clinical and ongoing pregnancy rate per started cycle was 13% and 11% respectively. 7 babies have thus far been born and none of the mothers or babies seroconverted within this study period. Larger numbers of patients are necessary to support the safety of this program.
authors.affiliation: Afd. Verloskunde en Gynaecologie, Centrum voor Voortplantingsgeneeskunde Academisch Medisch Centrum/Universiteit van Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam. e.vanleeuwen@amc.uva.nl
authors.forename: E
authors.initials: E
authors.lastname: van Leeuwen
authors.forename: J W A
authors.initials: JW
authors.lastname: de Vries
authors.forename: S
authors.initials: S
authors.lastname: Jurriaans
authors.forename: H R
authors.initials: HR
authors.lastname: Verhoeve
authors.forename: J M
authors.initials: JM
authors.lastname: Prins
authors.forename: S
authors.initials: S
authors.lastname: Repping
authors.forename: F
authors.initials: F
authors.lastname: van der Veen
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission*; D006679:HIV Seropositivity / Q000453:epidemiology*; D015497:HIV-1; D006801:Humans; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D012367:RNA, Viral / Q000032:analysis; D013094:Spermatozoa / Q000821:virology*; D016896:Treatment Outcome
chemical_list: D012367:RNA, Viral