title: [Hemostatic and fibrinolysis markers in the early phase of acute ischaemic stroke].
abstract: Stroke is the most frequent cause of focal brain damage. It seems that some coagulation and fibrinolysis abnormalities play an important role in this disease. We measured coagulation parameters in 39 patients with acute ischaemic stroke within 1 week of onset of the stroke (1st, 3rd and 7th day), including thrombin-antithrombin complex (TAT), prothrombin fragment F1+2 (F1+2), fibrin degradation products (D-dimer) and fibrinogen (FBG). Marker levels in stroke were compared with controls (n=25). A significant elevation of plasma concentration of TAT, F1+2 and fibrinogen was observed in all days of measurements (p < 0.001). D-dimer level was significantly elevated in 30.7% of patients at the 1st day and in 23.0% of patients at the 3rd day of stroke onset. Marker utility in acute stroke awaits a larger study.
authors.affiliation: Katedra i Klinika Hematoonkologii i Transplantacji Szpiku AM, Lublinie.
authors.forename: Maria
authors.initials: M
authors.lastname: Soroka-Wojtaszko
authors.forename: Anna
authors.initials: A
authors.lastname: Dmoszyńska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Słoma-Madej
authors.forename: Norbert
authors.initials: N
authors.lastname: Grzaśko
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011516:Prothrombin; D020521:Stroke / Q000097:blood*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; C045879:prothrombin fragment 1.2; D011516:Prothrombin; D005340:Fibrinogen