Viscoelastic and mechanical behavior of recombinant protein elastomers.
Recombinant DNA synthesis was employed to produce elastin-mimetic protein triblock copolymers containing chemically distinct midblocks. These materials displayed a broad range of mechanical and viscoelastic responses ranging from plastic to elastic when examined as hydrated gels and films. These properties could be related in a predictable fashion to polymer block size and structure. While these materials could be easily processed into films and gels, electrospinning proved a feasible strategy for creating protein fibers. All told, the range of properties exhibited by this new class of protein triblock copolymer in combination with their easy processability suggests potential utility in a variety of soft prosthetic and tissue engineering applications.
Nagapudi
Karthik
K
Department of Surgery, Emory University, Atlanta, GA 30322, USA.
Brinkman
William T
WT
Thomas
Benjamin S
BS
Park
Jung O
JO
Srinivasarao
Mohan
M
Wright
Elizabeth
E
Conticello
Vince P
VP
Chaikof
Elliot L
EL
D001672:Biocompatible Materials / Q000032:analysis / Q000737:chemistry*; D040761:Biomimetic Materials / Q000032:analysis / Q000737:chemistry*; D004548:Elasticity; D004549:Elastin / Q000737:chemistry* / Q000235:genetics / Q000648:ultrastructure*; D020724:Elastomers / Q000032:analysis / Q000737:chemistry*; D005240:Feasibility Studies; D008422:Materials Testing; D046912:Multiprotein Complexes / Q000032:analysis / Q000737:chemistry / Q000648:ultrastructure; D010316:Particle Size; D015202:Protein Engineering / Q000379:methods*; D011994:Recombinant Proteins / Q000737:chemistry* / Q000648:ultrastructure; D013314:Stress, Mechanical; D013329:Structure-Activity Relationship; D013718:Tensile Strength; D014783:Viscosity
D001672:Biocompatible Materials; D020724:Elastomers; D046912:Multiprotein Complexes; D011994:Recombinant Proteins; D004549:Elastin