title: Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells.
abstract: In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl-hydroxychromans metabolites (CEHCs). The extent of this metabolism and the inhibitory effect on cell growth followed the order of magnitude alpha-T<alpha-T3<gamma-T<gamma-T3. The partial inhibition of gamma-T3 metabolism by ketoconazole did not influence cell proliferation. These early findings may suggest that the transformation of vitamin E to CEHC is mostly a detoxification mechanism useful to maintain the malignant properties of prostate cancer cells.
authors.affiliation: University of Perugia, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, Via del Giochetto, 06126 Perugia, Italy. f.galli@unipg.it
authors.forename: Carmela
authors.initials: C
authors.lastname: Conte
authors.forename: Alessandro
authors.initials: A
authors.lastname: Floridi
authors.forename: Cristina
authors.initials: C
authors.lastname: Aisa
authors.forename: Marta
authors.initials: M
authors.lastname: Piroddi
authors.forename: Ardesio
authors.initials: A
authors.lastname: Floridi
authors.forename: Francesco
authors.initials: F
authors.lastname: Galli
mesh_terms: D002455:Cell Division / Q000187:drug effects*; D002839:Chromans / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D002839:Chromans; C483420:carboxyethyl-hydroxychroman; D014810:Vitamin E; C013649:plastochromanol 8; D007654:Ketoconazole