title: Capsaicin and the treatment of vulvar vestibulitis syndrome: a valuable alternative?
abstract: OBJECTIVE
  To assess the efficacy of topical capsaicin in the treatment of vulvar vestibulitis syndrome.
  
  
  METHODS
  Thirty-three consecutive women referred for vulvar vestibulitis syndrome were treated with topical capsaicin 0.05 %. The capsaicin cream was applied twice a day for 30 days, then once a Day for 30 days, and finally 2 times a week for 4 months.
  
  
  RESULTS
  In 19 patients (59%), improvement of symptoms was recorded, but no complete remission was observed. Symptoms recurred in all patients after the use of capsaicin cream was discontinued. A return to a twice-weekly topical application of the cream resulted in the improvement of symptoms. Severe burning was reported as the only side effect by all the patients.
  
  
  CONCLUSIONS
  Response to treatment was only partial, possibly due to the concentration of the compound being too low, or to the need for more frequent than daily applications. The therapeutic role of capsaicin should hence be confined to a last-choice medical approach.
authors.affiliation: Outpatients' Department of Vulvar Disease, Vittore Buzzi Hospital-ICP-First, Obstetrics and Gynecological Clinic, University of Milan, Milan, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Murina
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Radici
authors.forename: Vanda
authors.initials: V
authors.lastname: Bianco
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002211:Capsaicin / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004414:Dyspareunia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013577:Syndrome; D016896:Treatment Outcome; D014847:Vulvitis / Q000188:drug therapy*
chemical_list: D002211:Capsaicin