[Study on metronidazole resistance to Helicobacter pylori from three populations with different ethnics in Yunnan].
OBJECTIVE
To evaluate the prevalence of Helicobacter pylori (H.pylori) resistance to metronidazole among three populations in Yunnan.


METHODS
Susceptibilities to metronidazole among 109 H. pylori strains (33 H. pylori strains from Han, 31 H. pylori strains from Bai and 45 H. pylori strains from Naxi ethnic populations) were tested by Epsilometer test (E-test).


RESULTS
In 109 H. pylori strains, the overall metronidazole resistance rate was 67.89%. There were no significant difference in the metronidazole resistant rates of H. pylori among Han, Bai, Naxi populations Yunnan in terms of the distribution on age and upper gastroduodenal diseases. In the facet of gender, metronidazole resistant rate of H. pylori was significantly lower in Han males than in females (chi2=5.304, P=0.027), but not seen in the Bai or Naxi peoples.


CONCLUSIONS
Metronidazole resistance rate of H. pyloriin Yunnan was high, but no significant difference was found among Han, Bai, Naxi peoples in the province.
Hu
Yue-Yan
YY
Digestive Department, the First Affiliated Hospital, Kunming Medical College, Kunming 650032, China.
Zhou
Zeng-Fen
ZF
Nan
Qiong
Q
Jiang
Hai-Yan
HY
Zhang
Lei
L
Li
Xiao-Yan
XY
Duan
Li-Ping
LP
Chen
Ya-Rong
YR
D000328:Adult; D002681:China / Q000208:ethnology; D002908:Chronic Disease; D024881:Drug Resistance, Bacterial; D005260:Female; D005756:Gastritis / Q000382:microbiology*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D010437:Peptic Ulcer / Q000382:microbiology
D008795:Metronidazole