Theoretical models of possible compact nucleosome structures.
Chromatin structure seems related to the DNA linker length. This paper presents a systematic search of the possible chromatin structure as a function of the linker lengths, starting from three different low-resolution molecular models of the nucleosome. Gay-Berne potential was used to evaluate the relative nucleosome packing energy. Results suggest that linker DNAs, which bridges and orientate nucleosomes, affect both the geometry and the rigidity of the global chromatin structure.
Besker
Neva
N
Dipartimento di Scienze del Farmaco, Università G. D'Annunzio, Via dei Vestini 31, I-66100 Chieti, Italy. besker@cerm.unifi.it
Anselmi
Claudio
C
De Santis
Pasquale
P
D004247:DNA / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D009707:Nucleosomes / Q000737:chemistry* / Q000378:metabolism
D009707:Nucleosomes; D004247:DNA