title: Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP.
abstract: [reaction: see text] A screening program designed to find new antiinflammatory agents has identified the sponge meroterpenoid pelorol (1) as an in vitro activator of the inositol-5-phosphatase SHIP. Pelorol (1) and several functional group analogues have been synthesized from sclareolide (4).
authors.affiliation: Department of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, B.C., Canada V6T 1Z1.
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.forename: David E
authors.initials: DE
authors.lastname: Williams
authors.forename: Alice
authors.initials: A
authors.lastname: Mui
authors.forename: Christopher
authors.initials: C
authors.lastname: Ong
authors.forename: Gerald
authors.initials: G
authors.lastname: Krystal
authors.forename: Rob
authors.initials: R
authors.lastname: van Soest
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry*; D000072181:Inositol Polyphosphate 5-Phosphatases; D051379:Mice; D023421:Models, Animal; D015394:Molecular Structure; D010744:Phosphoric Monoester Hydrolases / Q000187:drug effects*; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D012717:Sesquiterpenes; C414692:pelorol; C109395:sclareolide; D010744:Phosphoric Monoester Hydrolases; D000072181:Inositol Polyphosphate 5-Phosphatases