The immunoepidemiology of human hookworm infection.
Advances in hookworm immunoepidemiology are reviewed. Recent studies demonstrate a mixed Th1/Th2 response in human hookworm infection, with immunosuppression of specific and nonspecific IFN-gamma responses. There is increasing evidence for protective immunity in human hookworm infection, including anti-larval IL-5- and IgE-dependent mechanisms, and for immunological interactions between hookworm infection and other diseases.
Quinnell
R J
RJ
School of Biology, University of Leeds, Leeds LS2 9JT, UK. r.j.quinnell@leeds.ac.uk
Bethony
J
J
Pritchard
D I
DI
D000722:Ancylostoma / Q000276:immunology* / Q000472:pathogenicity; D000724:Ancylostomiasis / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology; D000818:Animals; D006725:Hookworm Infections / Q000453:epidemiology* / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D017221:Necator americanus / Q000276:immunology* / Q000472:pathogenicity; D009332:Necatoriasis / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology