[Inhibition of joint destruction by methotrexate].
Methotrexate (MTX) plays an important role in treatment of rheumatoid arthritis (RA). It significantly reduce expected radiographic progression. Comparing with other traditional disease-modifying anti-rheumatic drugs (DMARDs), MTX slow radiographic progression during the first 2 years. Since combination with anti-tumor nectosis factor alpha (TNF-alpha) therapy has been shown to be effective for the early supression of disease activity, it could be usefull to minimize bone destruction in RA.
Wakabayashi
Takayuki
T
Division of Rheumatology, Department of Internal Medicine, Tokai University.
Jackson
Kanako
K
Yamada
Chiho
C
Suzuki
Yasuo
Y
Suzuki
Yasuo
Y