title: Does aging affect the response of vitamin E status to vitamin E depletion and supplementation?
abstract: A vitamin E depletion/supplementation study was conducted in 100 healthy 20-75-year-old volunteers. The responses of vitamin E status to 3-week dietary vitamin E restriction to approximately 25% of recommended intake and 2-month unrestricted dietary intake plus 800 IU/d of RRR-alpha-tocopherol were studied as a function of age. Plasma alpha-tocopherol concentrations were closely related to cholesterol concentrations, which increased with age (P < 0.001). Upon dietary restriction, plasma alpha-tocopherol concentrations decreased significantly (P < 0.001) but independently of age. Plasma alpha-tocopherol responses to supplementation increased significantly with age, but this effect disappeared after standardization for cholesterol. gamma-Tocopherol concentrations decreased to less than 30% of baseline.
authors.affiliation: Human Nutrition & Metabolism Research Training Center, Institute of Molecular Biosciences, Karl-Franzens University, Schubertstrasse 1, A-8010 Graz, Austria. brigitte.winklhoferroob@uni-graz.at
authors.forename: Brigitte M
authors.initials: BM
authors.lastname: Winklhofer-Roob
authors.forename: Johannes M
authors.initials: JM
authors.lastname: Roob
authors.forename: Michaela
authors.initials: M
authors.lastname: Maritschnegg
authors.forename: Grete
authors.initials: G
authors.lastname: Sprinz
authors.forename: Doris
authors.initials: D
authors.lastname: Hiller
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Marktfelder
authors.forename: Melanie
authors.initials: M
authors.lastname: Preinsberger
authors.forename: Sandra
authors.initials: S
authors.lastname: Wuga
authors.forename: Isabella
authors.initials: I
authors.lastname: Sundl
authors.forename: Beate
authors.initials: B
authors.lastname: Tiran
authors.forename: Nicolas
authors.initials: N
authors.lastname: Cardinault
authors.forename: Josep
authors.initials: J
authors.lastname: Ribalta
authors.forename: Edmond
authors.initials: E
authors.lastname: Rock
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D004032:Diet; D019587:Dietary Supplements; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D014810:Vitamin E / Q000008:administration & dosage*; D024502:alpha-Tocopherol / Q000008:administration & dosage* / Q000097:blood*
chemical_list: D014810:Vitamin E; D024502:alpha-Tocopherol