Expanding functional diversity of the coactivators.
Nuclear receptors (NR) function as ligand-regulated transcription factors that transduce hormonal signals from steroid hormones and other lipophillic ligands. NR-mediated transcription depends on coactivators, a diverse group of proteins that affect the transcriptional machinery in a variety of ways such as via their associated enzymatic activities as histone acetyltransferases, methyltransferases, ubiquitin ligases or as agents that integrate signaling via kinase-signaling pathways. Coactivators have various roles in the transcriptional process (i) as molecules that influence key points in the different stages of transcription, (ii) as integrators of environmental growth-factor and steroid-hormone signals, and (iii) as agents of carcinogenesis.
Lonard
David M
DM
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
O'Malley
Bert W
BW
D000818:Animals; D006801:Humans; D008954:Models, Biological; D011401:Promoter Regions, Genetic; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D012326:RNA Splicing; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic; D025801:Ubiquitin / Q000378:metabolism
D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex