title: Adjunctive subantimicrobial dose doxycycline in the management of institutionalised geriatric patients with chronic periodontitis.
abstract: OBJECTIVE
  To assess the efficacy of subantimicrobial dose doxycycline (SDD; 20 mg doxycycline twice daily) as an adjunct to scaling and root planing (SRP) in the treatment of moderate-severe chronic periodontitis (CP) in institutionalised elderly patients aged 65 years or older.
  
  
  BACKGROUND
  Previous studies have shown that SDD is of clinical benefit in the treatment of CP. However, the benefits of SDD in geriatric populations (65+ years) have not been determined.
  
  
  METHODS
  A 9-month, double-blind, randomised, placebo-controlled pilot study was conducted. 24 institutionalised geriatric patients (65 years or older) with evidence of CP manifested by baseline clinical attachment levels (CAL) 5-9 mm, probing depths (PD) 4-9 mm and bleeding on probing (BOP) were recruited. At baseline, patients were treated by a standardised episode of SRP, and randomised to receive either adjunctive SDD or placebo. Full mouth PD and CAL were measured using the manual UNC-15 periodontal probe at 3, 6, and 9 months post-baseline to assess the response to treatment. Periodontal sites were stratified by baseline PD value: sites with PD 4-5 mm were considered moderately diseased and sites with PD > or = 6 mm severely diseased.
  
  
  RESULTS
  The SRP + placebo resulted in PD reductions similar to those reported previously in the literature. At all time-points and in both moderate and deep sites, SRP + SDD resulted in significantly greater PD reductions relative to baseline than SRP + placebo. At month 9, in moderate sites, mean PD reductions of 1.57 +/- 0.11 mm were reported in the adjunctive SDD group, compared with 0.63 +/- 0.11 mm in the adjunctive placebo group (p < 0.001). In deep sites at month 9, mean PD reductions of 3.22 +/- 0.29 mm were reported in the adjunctive SDD group, compared with 0.98 +/- 0.31 mm in the adjunctive placebo group (p < 0.05). Similar improvements were observed for CAL in the SDD group compared with the placebo group. Significantly lower BOP scores were also recorded at month 9 in the SDD group (7.5%) compared with the placebo group (71.2%) (p < 0.01).
  
  
  CONCLUSIONS
  SDD used as an adjunct to SRP provides significant benefit for elderly patients with CP compared with SRP alone.
authors.affiliation: College of Dentistry, Ohio State University, Columbus, OH 43210, USA. mohammad.6@osu.edu
authors.forename: Abdel R
authors.initials: AR
authors.lastname: Mohammad
authors.forename: Philip M
authors.initials: PM
authors.lastname: Preshaw
authors.forename: Mark H
authors.initials: MH
authors.lastname: Bradshaw
authors.forename: Arthur F
authors.initials: AF
authors.lastname: Hefti
authors.forename: Christopher V
authors.initials: CV
authors.lastname: Powala
authors.forename: Michael
authors.initials: M
authors.lastname: Romanowicz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D004311:Double-Blind Method; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007326:Institutionalization; D008297:Male; D009735:Nursing Homes; D010518:Periodontitis / Q000188:drug therapy*; D010865:Pilot Projects
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline