title: Cardiac troponin I release in acute pulmonary embolism in relation to the duration of symptoms.
abstract: OBJECTIVE
  To evaluate the release of cardiac troponin I in normotensive patients with acute pulmonary embolism in relation to the duration of symptoms.
  
  
  METHODS
  Fifty-seven normotensive patients with acute pulmonary embolism were included in the study. Patients were divided into two groups based on the duration of symptoms at presentation: symptoms of < or =72 h, group A; symptoms of >72 h, group B. Serum cardiac troponin I levels were measured at presentation.
  
  
  RESULTS
  Mean age was 63+/-18 years and 23 (40%) patients were males. Thirty-three (58%) patients had symptoms of < or =72 h (group A) and 24 (42%) had symptoms of >72 h (group B). Both groups had similar prevalence of right ventricular dysfunction on echocardiography (55% [n=18] in group A vs. 42% [n=10] in group B, p=NS). Sixteen patients had elevated serum cardiac troponin I (mean+/-S.D. 3.3+/-2.3 ng/ml, range 0.6-8.3 ng/ml). Elevated serum cardiac troponin I was strongly associated with right ventricular dysfunction (p=0.015). All patients with elevated serum cardiac troponin I (n=16) were in group A (p<0.0001). Twelve of 18 (67%) patients with (p=0.0005) and 4 of 15 (27%) patients without (p=NS) right ventricular dysfunction had elevated serum cardiac troponin I. Thirteen of 16 (81%) patients with elevated serum cardiac troponin I had duration of symptoms < or =24 h at presentation.
  
  
  CONCLUSIONS
  The dynamics of cardiac troponin I release in acute pulmonary embolism in patients who present with symptoms of < or =72 h duration could be different from those who present with longer duration of symptoms. Therefore, the use of cardiac troponin I in risk stratification of acute pulmonary embolism might be limited to the patients presenting within 72 h of the onset of symptoms.
authors.affiliation: Division of Cardiology, Long Island College Hospital, Brooklyn, NY, USA.
authors.forename: Gopikrishna
authors.initials: G
authors.lastname: Punukollu
authors.forename: Ijaz A
authors.initials: IA
authors.lastname: Khan
authors.forename: Ramesh M
authors.initials: RM
authors.lastname: Gowda
authors.forename: Gaurav
authors.initials: G
authors.lastname: Lakhanpal
authors.forename: Balendu C
authors.initials: BC
authors.lastname: Vasavada
authors.forename: Terrence J
authors.initials: TJ
authors.lastname: Sacchi
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011379:Prognosis; D011655:Pulmonary Embolism / Q000097:blood* / Q000150:complications; D018570:Risk Assessment; D013997:Time Factors; D019210:Troponin I / Q000097:blood*; D018497:Ventricular Dysfunction, Right / Q000097:blood / Q000150:complications / Q000401:mortality
chemical_list: D015415:Biomarkers; D019210:Troponin I