[Effect of combination treatment with estrogen and vitamin D3 on postmenopausal boneless].
Estrogen deficiency and low calcium intake are important contributors to the development of osteoporosis in postmenopausal women. Hormone replacement therapy (HRT) has been shown to be effective prevention of postmenopausal bone loss. Due to a potent action of anti-bone-resorption, HRT causes a secondary elevation of serum PTH and correction of calcium imbalance is mandatory for long-term HRT. Administration of vitamin D in combination with HRT is rational and is shown to be more effective than HRT alone.
Mizunuma
Hideki
H
Department of Obst. and Gynecol Hirosaki University School of Medicine.