A pilot case-control study of gamma-radiation sensitivity and risk of papillary thyroid cancer.
In vitro gamma-radiation-induced chromatid breaks per cell (b/c) in lymphocytes may be associated with risk of papillary thyroid cancer (PTC). This pilot case-control study involved 106 patients with thyroid disease (57 with PTC and 49 with benign thyroid disease) and 105 cancer-free matched controls. Multivariate logistic regression analyses identified that an elevated gamma-radiation-induced b/c value was a risk factor for PTC (adjusted odds ratio = 4.54; 95% CI, 2.07-9.95), and a dose-response relationship was evident when the b/c values were categorized into tertiles. High levels of chromatid breaks induced by gamma-radiation may constitute an independent risk factor for PTC, but further study is needed.
Xiong
Ping
P
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030-4009, USA.
Zheng
Rong
R
Wang
Li-E
LE
Bondy
Melissa L
ML
Shen
Hongbing
H
Borer
Mary M
MM
Wei
Qingyi
Q
Sturgis
Erich M
EM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D010865:Pilot Projects; D012307:Risk Factors; D013959:Thyroid Diseases / Q000453:epidemiology; D013964:Thyroid Neoplasms / Q000453:epidemiology*