Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors.
BACKGROUND
Patients with basal cell carcinoma (BCC) frequently develop further tumors during follow-up.


OBJECTIVE
We sought to elucidate the relative effects of pattern of ultraviolet radiation exposure, and site and histologic type of the first tumor, on the rate of increase in BCC numbers.


METHODS
We used negative binomial regression analysis to study the association of selected variables on the rate of increase in BCC numbers in 266 Caucasian patients who first presented with a tumor on the head/neck or trunk with nodular or superficial histology.


RESULTS
Patients with an initial truncal BCC with superficial histology demonstrated significantly faster increases in BCC numbers than did patients with other site and histology combinations.


CONCLUSIONS
These data indicate that site and histology define subsets of patients with BCC.
Lovatt
Tracy J
TJ
Human Genomics Research Group, Institute of Science and Technology in Medicine, Keele University School of Medicine, Hartshill Campus, University Hospital of North Staffordshire, United Kingdom.
Lear
John T
JT
Bastrilles
Jean
J
Wong
Christina
C
Griffiths
Christopher E M
CE
Samarasinghe
Venura
V
Roebuck
Jamie
J
Ramachandran
Sudarshan
S
Smith
Andrew G
AG
Jones
Peter W
PW
Fryer
Anthony A
AA
Strange
Richard C
RC
D000368:Aged; D002280:Basal Cell Carcinoma / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology*; D012878:Skin Neoplasms / Q000453:epidemiology / Q000473:pathology*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D044465:White People