[Clinical aspects of estrogen and bone metabolism].
Estrogen depletion by menopause decreases bone mineral density and the replacement of this hormone restores the bone loss. Although these are evident, there are not enough evidences for the prevention of osteoporotic fractures, particularly femoral neck fractures. Recent reports suggested that the concomitant use of progesterone is not beneficial but increases several adverse events.
Hosoi
Takayuki
T
Endocrinology Section, Tokyo Metropolitan Geriatric Center.