[Osteoporosis].
The diagnosis of osteoporosis is based on the bone mineral density measurement using DXA technology, but the concept of bone quality mainly related to bone architecture is of great interest. The diagnostic threshold of osteoporosis is more and more modulated according to fracture risk factors such as age, prevalent fractures, bone turn-over leading to the definition of a therapeutic threshold. The use of bone resorption inhibitors before or with teriparatide decrease the response of the biochemical markers of bone formation and the gain in bone mineral density. The efficacy of strontium ranelate to decrease vertebral fracture incidence is confirmed and presented on non-vertebral fractures. Bisphosphonates are rapidly effective to prevent fractures and with a long term efficacy. Vitamin D treatment is effective to prevent falls.
Uebelhart
B
B
Service des maladies osseuses, Centre collaborateur de l'OMS pour la prévention de l'ostéoporose, Département de rehabilitation et de gériatrie, Hôpitaux universitaires de Genève 1211 Genève 14. Brigitte.Uebelhart@hcuge.ch
Rizzoli
R
R
D001842:Bone and Bones / Q000502:physiology; D006801:Humans; D010024:Osteoporosis / Q000175:diagnosis / Q000188:drug therapy