An in silico study of energy metabolism in cardiac excitation-contraction coupling.
The heart produces and uses ATP at a high rate. Each step involved in ATP metabolism has been extensively studied. However, functional coupling between ATP production and membrane excitation-contraction coupling, which is the main ATP consumption process, is not yet fully understood because of complicated interactions and the lack of quantitative data obtained in vivo. Computer simulation is a powerful tool for integrating experimental data and for solving their complicated interactions. To investigate the mechanisms underlying cardiac excitation-contraction-energy metabolism coupling, we have developed a computer model of cardiac excitation-contraction coupling (Kyoto model) that includes the major processes of ATP production, such as oxidative phosphorylation that was originally developed for skeletal muscle by Korzeniewski and Zoladz [Biophys Chem 92: 17-34, 2001], creatine kinase, and adenylate kinase. In this review, we briefly summarize cardiac energy metabolism and discuss the regulation of mitochondrial ATP synthesis, using the Kyoto model.
Matsuoka
Satoshi
S
Department of Physiology and Biophysics, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan. matsuoka@card.med.kyoto-u.ac.jp
Jo
Hikari
H
Sarai
Nobuaki
N
Noma
Akinori
A
D000255:Adenosine Triphosphate / Q000378:metabolism; D003198:Computer Simulation; D004734:Energy Metabolism / Q000502:physiology*; D008929:Mitochondria, Heart / Q000378:metabolism; D008954:Models, Biological; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*
D000255:Adenosine Triphosphate