title: Low-salt O-miso produced from Koji fermentation of oncom improves redox state and cholesterolemia in rats more than low-salt soybean-miso.
abstract: The author prepared low-salt miso by koji fermentation using soy-oncom and okara-oncom (9:1), at which time soybeans and okara were fermented with Neurospora intermedia (oncom miso, i.e. O-miso). Its usefulness as a seasoning, as well as high antioxidative activity in vitro and antimutagenicity have already been presented. In this study, the antioxidative activity of O-miso in vivo, as well as serum cholesterol-lowering action, were investigated concerning contribution to health. In rats fed O-miso, the serum alpha-tocopherol level and isoflavone-aglycone-intake were higher than in rats fed low-salt soybean miso (S-miso). The activities of serum GSH-Px and hepatic catalase were also higher in rats fed O-miso than in rats fed S-miso, while the TBARS values were lower in both the serum and livers of rats fed O-miso. Furthermore, O-miso intake suppressed a rise in serum cholesterol level and increased fecal bile acid excretion. Such a cholesterol-lowering action of O-miso may be attributable to the micelle-breaking or evacuant effects of indigestible proteinous residues and the antioxidative activity of isoflavone-aglycones. O-miso seems to be more beneficial to health than S-miso in view of these aspects.
authors.affiliation: Faculty of Home Science, Gifu Women's University, Gifu 501-2592, Japan. matsuo@gijodai.ac.jp
authors.forename: Masako
authors.initials: M
authors.lastname: Matsuo
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts / Q000032:analysis / Q000378:metabolism; D002374:Catalase / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D005243:Feces / Q000737:chemistry; D005285:Fermentation; D005511:Food Handling / Q000379:methods*; D005979:Glutathione Peroxidase / Q000097:blood; D007529:Isoflavones / Q000008:administration & dosage; D008297:Male; D009491:Neurospora / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000032:analysis*; D045730:Soy Foods / Q000032:analysis*; D030262:Soybean Proteins / Q000378:metabolism; D013025:Glycine max; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts; D007529:Isoflavones; D030262:Soybean Proteins; D012965:Sodium Chloride; D002784:Cholesterol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase