title: Serum insulin-like growth factor-1 is an independent predictor of prognosis in patients with renal cell carcinoma.
abstract: Obesity is associated with an increased risk of certain cancers, including renal cell carcinoma. A possible mediator of this risk is insulin-like growth factor-1 (IGF-1). The authors evaluated the prognostic information of IGF-1, IGFBP-3, leptin, and prealbumin in sera sampled at diagnosis from 256 consecutive patients with renal cell carcinoma. Insulin-like growth factor-1 and leptin were positively correlated to body mass index (BMI). Insulin-like growth factor-1 and IGFBP-3 did not correlate to tumour stage or grade. Leptin and prealbumin were both inversely related to tumour stage and grade. When survival was analysed in patients with levels above a median of IGF-1, leptin, and prealbumin, prognosis was more favourable, compared with those with lower levels (p=0.017; p=0.024, and p<0.0001, respectively). In a multivariate analysis, tumour stage and serum IGF-1 levels were independent prognostic factors. The results indicate that serum IGF-1 at diagnosis is related to prognosis in renal cell carcinoma.
authors.affiliation: Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden. Torgny.Rasmuson@onkologi.umu.se
authors.forename: Torgny
authors.initials: T
authors.lastname: Rasmuson
authors.forename: Kjell
authors.initials: K
authors.lastname: Grankvist
authors.forename: Jan
authors.initials: J
authors.lastname: Jacobsen
authors.forename: Tommy
authors.initials: T
authors.lastname: Olsson
authors.forename: Börje
authors.initials: B
authors.lastname: Ljungberg
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001707:Biopsy, Needle; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012737:Sex Factors; D018709:Statistics, Nonparametric; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D007334:Insulin-Like Growth Factor I