title: The cognitive burden of multiple sclerosis in children.
abstract: Little is known about the cognitive sequelae of pediatric-onset multiple sclerosis (MS). Ten pediatric patients with MS were evaluated using a comprehensive neuropsychological battery. Neuropsychological deficits were identified on measures of general cognition, language, visuomotor integration, and verbal and visual memory. Cognitive impairment occurs in children with MS, and those with longer disease duration and younger age at MS onset appear to be at greatest risk.
authors.affiliation: Research Institute, Multiple Sclerosis Clinic, The Hospital for Sick Children, Toronto, Ontario, Canada. brenda.banwell@sickkids.ca
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Banwell
authors.forename: Peter E
authors.initials: PE
authors.lastname: Anderson
mesh_terms: D000293:Adolescent; D000367:Age Factors; D017668:Age of Onset; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002170:Canada; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology*; D015331:Cohort Studies; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009483:Neuropsychological Tests; D010865:Pilot Projects; D011237:Predictive Value of Tests
chemical_list: D007155:Immunologic Factors