[Transcriptional regulation of the sarcoplasmic reticulum Ca2+ -ATPase gene].
Sarcoplasmic reticulum Ca(2+)-ATPase is a key protein which takes Ca(2+) up into sarcoplasmic reticulum, thereby controls relaxation of cardiac muscle. The expression level of Ca(2+)-ATPase mRNA is regulated transcriptionally under various pathophysiological conditions. The E-Box, CArG Box, and MCAT element are essential for the muscle-specific transcription of the gene. Egr-1 sites in the proximal regulatory region of the gene are responsible for the decreased expression of Ca(2+)-ATPase mRNA in heart failure. Additionally, both proximal and distal regulatory elements are important for the transcriptional suppression of the gene.
Arai
M
M
Second Department of Internal Medicine, Gunma University School of Medicine.