title: [Effect of the corticoliberin fragment CRF(4-6) on blood pressure and heart rate in rats].
abstract: The effects of tripeptide corticoliberin fragment CRF(4-6) (Pro-Pro-Ile) on blood pressure and heart rate of rats were investigated. Intracerebroventricularly injected CRF(4-6) (1.5-15.0 nmol/head) increases the mean arterial pressure and heart rate in conscious and anaesthetized animals in a dose-dependent manner. Corticotropin releasing factor antagonist: alpha-helical CRF(9-41) (6.5 nmol) completely abolished the influence of tripeptide CRF(4-6) (1.5 nmol) on blood pressure and heart rate in anaesthetized rats. This result indicates that corticoliberin receptors are involved in cardiovascular effects of CRF(4-6).
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Makarenko
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: A S
authors.initials: AS
authors.lastname: Borovik
authors.forename: A A
authors.initials: AA
authors.lastname: Mart'ianov
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors
chemical_list: D010446:Peptide Fragments; D018019:Receptors, Corticotropin-Releasing Hormone; C488808:prolyl-prolylisoleucine; D003346:Corticotropin-Releasing Hormone; C045089:corticotropin releasing hormone (9-41)