[Effect of compound shenhua tablet on macrophage migration inhibition factor in renal tissue of 5/6 nephrectomized rats].
OBJECTIVE
To observe the effect of compound shenhua tablet (CST) on the residual kidney expressed macrophage migration inhibition factor (MIF) in rats.


METHODS
CST was used to treat 5/6 nephrectomized rats for 12 weeks and the conditions of blood pressure, urinary protein, blood biochemical indices (creatinine, blood urea nitrogen), kidney pathologic change and MIF expression were observed.


RESULTS
CST could significantly lower the serum levels of creatinine (P < 0.05), and 24 hrs urinary protein (P < 0.01), reduce the MIF expression and macrophage infiltration in renal glomerulus and tubular mesenchym, and lower the degree of renal glomerular sclerosis and interstitial fibrosis.


CONCLUSIONS
The inhibition on the highly expressed MIF may be an important mechanism of the drug in restraining chronic inflammation in residual kidney, delaying the sclerosis and fibrosis progression and protecting renal function.
Li
Jian-jun
JJ
Department of Nephrology, General Hospital of PLA, Beijing 100085.
Chen
Xiang-mei
XM
Gu
Yue
Y
Wei
Ri-bao
RB
Du
Jing
J
Shi
Suo-zhu
SZ
Yi
Zhong
Z
D000419:Albuminuria / Q000097:blood; D000818:Animals; D003404:Creatinine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005355:Fibrosis / Q000473:pathology; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets
D004365:Drugs, Chinese Herbal; D008263:Macrophage Migration-Inhibitory Factors; D013607:Tablets; C000592784:shenhua; D003404:Creatinine