No association of the Trp 64 Arg mutation of the beta3-adrenergic receptor gene with obesity, type 2 diabetes mellitus, hyperlipidemia, and hypertension in Japanese patients with schizophrenia.
OBJECTIVE
This study was conducted to address the question of whether the beta3-adrenergic receptor gene mutation (Trp 64 Arg) is associated with metabolic disease in Japanese patients with schizophrenia.


METHODS
In a cross-sectional study, 89 participants were grouped into three genotypes. The 64 Arg allelic frequency in patients with or without metabolic disease was analyzed. Anthropometrics variables and biochemical parameters were compared among the genotypes.


RESULTS
The 64Arg allele, which had a frequency of 0.22, was not associated with obesity, type 2 diabetes mellitus, dyslipidemias, or hypertension. No significant differences among the genotypes were found in current age, age at diagnosis with schizophrenia, body mass index, waist-hip ratio, plasma glucose, plasma insulin, triglycerides, free fatty acids. Patients with the 64 Arg allele had greater 24-h excretion of norepinephrine than those lacking the variant (p = 0.019).


CONCLUSIONS
The 64 Arg allelic mutation is not associated with obesity, type 2 diabetes mellitus, lipid metabolism dysfunction, or hypertension in Japanese patients with schizophrenia.
Nagano
Takamasa
T
Division of Psychiatry, Hosogi Unity Hospital, Kochi, Japan.
Matsuda
Yukihiko
Y
Tanioka
Tetsuya
T
Yoshioka
Takaoki
T
Hiroi
Tadashi
T
Yoshikawa
Kenichi
K
Okabe
Ken-ichiro
K
Osaka
Kyoko
K
Nagamine
Isao
I
Takasaka
Yoichiro
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002395:Catecholamines / Q000652:urine; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000235:genetics; D006973:Hypertension / Q000150:complications / Q000235:genetics; D007564:Japan; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics; D017354:Point Mutation; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D012559:Schizophrenia / Q000150:complications / Q000235:genetics* / Q000378:metabolism
D002395:Catecholamines; D022702:Receptors, Adrenergic, beta-3