[Effect of nickel sulfate on the concentrations of T3, T4 and TSH in serum of rat].
The effect of nickel sulfate on the concentrations of T3, T4 and TSH in sera of rats was studied. Forty wistar male rats were divided into four groups. The rats in groups 1, 2 and 3 were injected with 0.005 mol/L NiSO4, 0.01 mol/L NiSO4 and 0.02 mol/L NiSO4 [1 ml/(kg x d)] respectively, while the rats of group 4 were injected with normal saline, serving as control. Forty days later, the concentrations of T3 and T4 in sera of 0.01 mol/L NiSO4 and 0.02 mol/L NiSO4 groups were obviously decreased (P<0.05 or P<0.01). The concentrations of T4 in sera of 0.005 mol/L NiSO4 group was also decreased, compared with control group. There was no difference in the concentrations of T3 and T4 in sera among the groups with different doses of NiSO4. Between different dose groups and the control group, the concentrations of TSH in sera showed no significant difference (P>0.05). The proliferation of the epithelial cells of thyroid gland was noticed. The rough endoplasmic reticulam was exceedingly expanded. The nuclei were transformed. The results suggest that Ni may injure thyroid gland.
Cheng
W
W
College of Basic Medical Science, Hebei Medical University, Shijiazhuang 050031, China.
Zhou
Z
Z
Yang
Y
Y
Yin
C
C
Chai
G W
GW
D000818:Animals; D007509:Irritants / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D009532:Nickel / Q000008:administration & dosage* / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
D007509:Irritants; C029938:nickel sulfate; D009532:Nickel; D013972:Thyrotropin; D013974:Thyroxine