title: Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction.
abstract: The interleukin (IL)-18 level in plasma is elevated during the acute rejection after organ transplantation. IL-18 elicits adhesion molecule expression as well as interferon-gamma/IL-12 production and T-cell proliferation in the human mixed lymphocyte reaction, an in vitro model of acute rejection. We examined whether antibodies (Abs) against intercellular adhesion molecule (ICAM)-1, B7, CD40, and CD40, ligand (CD40L) affect the cytokine production and T-cell proliferation. Anti-ICAM-1 and B7 Abs suppressed the cytokine production, while all Abs inhibited T-cell proliferation. ICAM-1 and B7 as well as CD40 may play different roles in the acute rejection.
authors.affiliation: Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama City.
authors.forename: Hideo Kohka
authors.initials: HK
authors.lastname: Takahashi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Iwagaki
authors.forename: Ryuji
authors.initials: R
authors.lastname: Tamura
authors.forename: Takahito
authors.initials: T
authors.lastname: Yagi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.forename: Shuji
authors.initials: S
authors.lastname: Mori
authors.forename: Noriaki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishibori
mesh_terms: D000906:Antibodies / Q000378:metabolism*; D018122:B7-1 Antigen / Q000187:drug effects / Q000378:metabolism*; D019013:CD40 Antigens / Q000187:drug effects / Q000378:metabolism*; D023201:CD40 Ligand / Q000187:drug effects / Q000378:metabolism; D015815:Cell Adhesion Molecules; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D007371:Interferon-gamma / Q000096:biosynthesis / Q000187:drug effects; D018664:Interleukin-12 / Q000096:biosynthesis; D020382:Interleukin-18 / Q000494:pharmacology*; D007959:Lymphocyte Culture Test, Mixed; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D000906:Antibodies; D018122:B7-1 Antigen; D019013:CD40 Antigens; D015815:Cell Adhesion Molecules; D020382:Interleukin-18; D018799:Intercellular Adhesion Molecule-1; D023201:CD40 Ligand; D018664:Interleukin-12; D007371:Interferon-gamma