Metabolism of alcohol.
Most tissues of the body contain enzymes capable of ethanol oxidation or nonoxidative metabolism, but significant activity occurs only in the liver and, to a lesser extent, in the stomach. Hence, medical consequences are predominant in these organs. In the liver, ethanol oxidation generates an excess of reducing equivalents, primarily as NADH, causing hepatotoxicity. An additional system, containing cytochromes P-450 inducible by chronic alcohol feeding, was demonstrated in liver microsomes and found to be a major cause of hepatotoxicity.
Lieber
Charles S
CS
Bronx VA Medical Center (151-2), 130 West Kingsbridge Road, Bronx, NY 10468, USA. liebercs@aol.com
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000437:Alcoholism / Q000150:complications / Q000378:metabolism*; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D018450:Disease Progression; D000431:Ethanol / Q000378:metabolism*; D005260:Female; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D018384:Oxidative Stress; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index
D000431:Ethanol; D000429:Alcohol Oxidoreductases