title: [Central giant cell lesions of the jaws: a clinicopathological study of 31 cases].
abstract: OBJECTIVE
  To study the clinicopathologic features of central giant cell granuloma (CGCG) of the jaws and the relationship between the pathologic features and its clinical behavior.
  
  
  METHODS
  Histologic, radiographic and follow-up information for 31 cases of central giant cell granuloma were reviewed. The histopathologic patterns were analyzed between nonrecurrent and recurrent cases for which the following-up information was available.
  
  
  RESULTS
  The majority of the giant cell granuloma of the jaws occurred in patients under 30 with a predilection of females and mostly were involved in the mandible. The radiographic features of CGCG non-specific. The multinucleated giant cell scattered unevenly, the numbers of the nuclei were few and mostly 10-19. The marked fibrosis, the multiple area of hemorrhage, abundant hemosiderin and newly formed bone were always present in the lesions. No significant difference exited between the recurrence and nonrecurrence groups in the pathologic features. The patients with aggressive behavior showed more consistent with the recurrence.
  
  
  CONCLUSIONS
  CGCG was a non-neoplastic lesion of the jaws which was different from the giant cell tumor. It was difficult to distinguish between the CGCG and giant cell tumor (GCT), and to predict its clinical behavior only by the histopathological patterns. It was helpful to combine the clinical presentation of CGCG with its treatment.
authors.affiliation: Department of Oral Pathology, Peking University School of Stomatology, Beijing 100081, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Shi-feng
authors.initials: SF
authors.lastname: Yu
authors.forename: Yun-tang
authors.initials: YT
authors.lastname: Wu
authors.forename: Shu-zhen
authors.initials: SZ
authors.lastname: Pang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006101:Granuloma, Giant Cell / Q000473:pathology*; D006801:Humans; D007223:Infant; D007571:Jaw Diseases / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D055815:Young Adult