From molecular networks to qualitative cell behavior.
Adaptation and behavior are characteristics of life which are fundamentally dynamic. If we want to model the living cell we have to describe it as a dynamic system. Typical dynamic models are based on quantitative differential equations requiring very detailed kinetic knowledge. Alternative modeling techniques for less fine-grained information are better suited to available functional genomics data. As such, constraint-based techniques and qualitative modeling have proven themselves to be valid approaches in cell biology. These approaches offer formal support to check the consistency of molecular networks against phenotypic observations in the light of dynamic systems.
Gagneur
Julien
J
Cellzome AG, Meyerhofstr. 1, 69117 Heidelberg, Germany. julien.gagneur@cellzome.com
Casari
Georg
G
D002477:Cells; D019295:Computational Biology; D007700:Kinetics; D008954:Models, Biological; D008962:Models, Theoretical