More than just proliferation: Myc function in stem cells.
Adult stem cells are essential to maintain regenerative tissues such as skin epidermis, gastrointestinal mucosa or the hematopoietic system. Recent studies in mice suggest that the transcription factor and oncoprotein c-Myc has unexpected functions during both self-renewal and the differentiation of stem and early progenitor cells, particularly in interactions between stem cells and the local microenvironment or "niche". By incorporating recent findings on Myc and hematopoietic stem cells we propose a model in which "resting" hematopoietic stem cells are "activated" to self-renew and to differentiate at the interface between the niche and non-niche microenvironments.
Murphy
Mark J
MJ
Genetics and Stem Cell Laboratory; Swiss Institute for Experimental Cancer Research (ISREC), Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.
Wilson
Anne
A
Trumpp
Andreas
A
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D004622:Embryo, Mammalian / Q000166:cytology; D004625:Embryo, Nonmammalian; D004817:Epidermis / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000473:pathology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009432:Neural Crest / Q000166:cytology; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D012867:Skin / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D014981:Xenopus
D016271:Proto-Oncogene Proteins c-myc