title: [Effect of hypertension on cell proliferation and apoptosis in benign prostatic hyperplasia].
abstract: OBJECTIVE
  To evaluate the effect of hypertension on cell proliferation and apoptosis in benign prostatic hyperplasia (BPH).
  
  
  METHODS
  The techniques of immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP biotin nick end labeling(TUNEL) were used to detect the proliferative index (PI) and apoptotic index (AI) in both epithelium and stroma of simple BPH (40 cases) and BPH with hypertension (40 cases), respectively.
  
  
  RESULTS
  In both the groups of simple BPH and BPH with hypertension, the value of PI was significantly higher than that of AI in epithelium and stroma (P < 0.05), and PI was closely related to the prostate volume (P < 0.05). As compared with the simple BPH group, PI was significantly increased in epithelium and stroma in the group of BPH with hypertension( P < 0.05), in which the disease history of hypertension was positively associated with PI in epithelium and stroma (p < 0.05).
  
  
  CONCLUSIONS
  Hypertension, particularly persistent hypertension state, may enhance cell proliferation in both epithelium and stroma of BPH, and consequently lead to the enlargement of the prostate.
authors.affiliation: Department of Urology, Peking University First Hospital/Institute of Urology, Peking University, Beijing 100034, China.
authors.forename: Pei-Jun
authors.initials: PJ
authors.lastname: Li
authors.forename: Xiang-Hua
authors.initials: XH
authors.lastname: Zhang
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Guo
authors.forename: Yan-Qun
authors.initials: YQ
authors.lastname: Na
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000502:physiology*; D049109:Cell Proliferation; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*