[Widal triad (Asthma-Nasal polyposis-aspirin intolerance): an inflammatory metabolism abnormality].
Widal disease is characterized by symptomatic triad of aspirin intolerance, nasal polyposis and asthma. This disease is closely linked to abnormalities of the arachidonic acid metabolism. Partly of genetic origin, these anomalies are also related to the immune system function and probably to age. These factors induce an increase of cysleukotriene synthetase enzyme, and consequently an overproduction of cysleukotrienes that have both proinflammatory and bronchoconstrictive effects. In recent years, encouraging results were obtained with anti-leukotrienes, especially when they are associated with topic corticosteroids. Finally, numerous research that attempt to reach a better understanding of arachidonic acid metabolism are underway, which enables us to hope for future therapeutic advances.
Leimgruber
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Service d'immunologie et d'allergie, CHUV, 1011 Lausanne. annette.leimgruber@hospvd.ch
D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D008659:Metabolic Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D009298:Nasal Polyps / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*
D001241:Aspirin