Effect of vitamin E supplementation on microalbuminuria, lipid peroxidation and blood prostaglandins in diabetic patients.
BACKGROUND
Oxidative stress is an important pathogenic factor in the development of diabetic vascular complications.


OBJECTIVE
To study the effect of vitamin E supplementation on microalbuminuria, plasma levels of malondialdehyde (MLD) and metabolites of prostaglandins TXA2 (TXB2) and PGI2 (6-keto-PGF1alpha) and to evaluate the relation between plasma MLD and thromboxane B2 (TXB2) in diabetic patients.


METHODS
Diabetic microalbuminuric patients were supplemented with vitamin E 1200 IU daily (EVIT, Rodisma, Germany) and measurements of microalbuminuria, MLD, TXB2 and 6-ketoPGF1alpha were repeated after 4 months of treatment.


RESULTS
Vitamin E supplementation lowered microalbuminuria (93.8 +/- 45.6 vs 67.95 +/- 28.4 microg/min, p < 0.05), MLD (0.55 +/- 0.26 vs 0.32 +/- 0.16 micromol/l, p < 0.001) and also TXB2 level (115.14 +/- 22.7 vs 15.32 +/- 14.7 ng/l, p < 0.001) in diabetic microalbuminuric patients. The changes of 6-keto-PGF1alpha after treatment were not significant.


CONCLUSIONS
Our results did not show any significant relationship between levels of MLD and TXB2. Vitamin E supplementation significantly lowered microalbuminuria, MLD and TXB2. (Tab. 2, Fig. 2, Ref. 35).
Hirnerova
E
E
2nd Department of Internal Medicine, University Hospital, Faculty of Medicine, Comenius University, Bratislava, Slovakia. hirnerova@hotmail.com
Krahulec
B
B
Strbova
L
L
Stecova
A
A
Dekret
J
J
Hajovska
A
A
Ch
Antwi
A
Dukat
A
A
D000419:Albuminuria; D000975:Antioxidants / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000378:metabolism*; D011464:Epoprostenol / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D011453:Prostaglandins / Q000097:blood*; D013931:Thromboxanes / Q000097:blood; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D011453:Prostaglandins; D013931:Thromboxanes; D014810:Vitamin E; D008315:Malondialdehyde; D011464:Epoprostenol