HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses.
Several published epidemiologic studies show increased breast cancer risk for carriers of the Val-allele at codon 655 of the HER2 gene. We conducted additional analyses using data from three studies, including case-control analyses stratified on age and kin-cohort analyses using relatives of cases and controls. The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer.
Millikan
Robert C
RC
Department of Epidemiology, School of Public Health, University of North Carolina, CB #7435, Chapel Hill, NC 27599-7435, USA. millikan@email.unc.edu
Hummer
Amanda J
AJ
Wolff
Mary S
MS
Hishida
Asahi
A
Begg
Colin B
CB
D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D003062:Codon; D015331:Cohort Studies; D005260:Female; D018734:Genes, erbB-2; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D012307:Risk Factors
D003062:Codon