title: [Risk factors that modulate periodontal diseases].
abstract: Periodontal diseases now is a chronic inflammatory disease caused by Gram negative bacterial infection. Recently, it is of interest to evaluate risk factors that modulate initiation and development of this disease. A recent study have suggested that obesity is one of the risk factors. In this regard, most recently, we found that leptin, a regulator of food intake and whole-body energy metabolism, acts as a negative regulator of LPS-induced expression of inflammatory cytokines of macrophages via inhibition of NF-kB.
authors.affiliation: Division of Oral Infectious Diseases and Immunology, Faculty of Dental Science, Kyushu University.
authors.forename: S
authors.initials: S
authors.lastname: Hanazawa