title: Calcium oxalate deposition in renal cell carcinoma associated with acquired cystic kidney disease: a comprehensive study.
abstract: The main complication of acquired cystic kidney disease (ACKD) is frequent development of renal tumors, including renal cell carcinoma (RCC). Intratumoral deposition of calcium oxalate (CaOx) is a distinct feature of ACKD-associated RCCs, but several features of this type of RCC are not known. Features of the 30 end-stage renal disease (ESRD)-associated RCCs identified within a 13-year period, including eight with CaOx deposition, were analyzed. Pathologic and clinical features of CaOx positive (+) and negative (-) RCCs were evaluated and compared. The CaOx+ RCCs showed higher tendency for bilaterality and multifocality. Seven tumors displayed distinctive morphologic features characterized by tumor cells with ill-defined cell membrane, abundant granular eosinophilic cytoplasm, large nuclei, and prominent nucleoli. One tumor was of clear cell type. Regardless of histologic type, all tumors displayed a proximal tubular differentiation. No significant difference was noted for tumors' stage, proliferation, and apoptosis rate between the CaOx+ and CaOx- RCCs. CaOx+ RCCs account for a significant portion of all ESRD-associated RCCs. The majority of these RCCs display a distinctive morphologic profile. Proximal tubular cell differentiation in conjunction with ESRD-mediated high serum level may be pathogenetically important for intratumoral CaOx deposition. These RCCs seems to have a relatively good prognosis.
authors.affiliation: Department of Pathology, Renal Section, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Norbert
authors.initials: N
authors.lastname: Sule
authors.forename: Ulkem
authors.initials: U
authors.lastname: Yakupoglu
authors.forename: Steven S
authors.initials: SS
authors.lastname: Shen
authors.forename: Bhuvaneswari
authors.initials: B
authors.lastname: Krishnan
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Seth
authors.initials: S
authors.lastname: Lerner
authors.forename: David
authors.initials: D
authors.lastname: Sheikh-Hamad
authors.forename: Luan D
authors.initials: LD
authors.lastname: Truong
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002114:Calcinosis / Q000378:metabolism* / Q000473:pathology; D002129:Calcium Oxalate / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D052177:Kidney Diseases, Cystic / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D007680:Kidney Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D002129:Calcium Oxalate