title: Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results.
abstract: BACKGROUND
  We evaluated the sedative, haemodynamic and respiratory effects of dexmedetomidine and compared them with those of midazolam in children undergoing magnetic resonance imaging (MRI) procedures.
  
  
  METHODS
  Eighty children aged between 1 and 7 yr were randomly allocated to receive sedation with either dexmedetomidine (group D, n=40) or midazolam (group M, n=40). The loading dose of the study drugs was administered for 10 min (dexmedetomidine 1 microg kg(-1) or midazolam 0.2 mg kg(-1)) followed by continuous infusion (dexmedetomidine 0.5 microg kg(-1) h(-1) or midazolam 6 microg kg(-1) min(-1)). Inadequate sedation was defined as difficulty in completing the procedure because of the child's movement during MRI. The children who were inadequately sedated were given a single dose of rescue midazolam and/or propofol intravenously. Mean arterial pressure (MAP), heart rate (HR), peripheral oxygen saturation (SpO2) and ventilatory frequency (VF) were monitored and recorded during the study.
  
  
  RESULTS
  The quality of MRI was significantly better and the rate of adequate sedation was higher in group D than in group M (P<0.001). In group D, the requirement for rescue drugs was lower and the onset of sedation time was shorter than in group M (P<0.001). MAP, HR and VF decreased from baseline during sedation in both groups (P<0.001).
  
  
  CONCLUSIONS
  Dexmedetomidine provided adequate sedation in most of the children aged 1-7 yr without haemodynamic or respiratory effects during MRI procedures.
authors.affiliation: Department of Anaesthesiology and Reanimation, Medical Faculty, Inonu University, Malatya, Turkey. akoroglu@inonu.edu.tr
authors.forename: A
authors.initials: A
authors.lastname: Koroglu
authors.forename: S
authors.initials: S
authors.lastname: Demirbilek
authors.forename: H
authors.initials: H
authors.lastname: Teksan
authors.forename: O
authors.initials: O
authors.lastname: Sagir
authors.forename: A K
authors.initials: AK
authors.lastname: But
authors.forename: M O
authors.initials: MO
authors.lastname: Ersoy
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D016292:Procedural Sedation / Q000379:methods*; D020927:Dexmedetomidine / Q000494:pharmacology*; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008874:Midazolam / Q000494:pharmacology; D011446:Prospective Studies; D012119:Respiration / Q000187:drug effects*
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D008874:Midazolam