title: Distribution of CCR5-delta32, CCR2-64I, and SDF1-3'A mutations in populations from the Brazilian Amazon region.
abstract: The frequency distribution of the CCR5-delta32, CCR2-64I, and SDF1-3'A alleles was studied in the urban population of Belém and in Afro-Brazilians, Amerindians, and Japanese immigrants in the state of Pará, Brazil. The results suggest that Amerindians may be genetically more susceptible to HIV-1 infection and disease progression than the other human groups studied.
authors.affiliation: Laboratory of Human and Medical Genetics, Department of Pathology, Center for Biological Sciences, Federal University of Pará, 66075-900 Belém, Para, Brazil.
authors.forename: Fernanda Andreza
authors.initials: FA
authors.lastname: De Pinho Lott Carvalhaes
authors.forename: Greice Lemos
authors.initials: GL
authors.lastname: Cardoso
authors.forename: Igor Guerreiro
authors.initials: IG
authors.lastname: Hamoy
authors.forename: Yan Tat
authors.initials: YT
authors.lastname: Liu
authors.forename: João Farias
authors.initials: JF
authors.lastname: Guerreiro
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D001938:Brazil; D018925:Chemokines / Q000235:genetics; D018450:Disease Progression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D005828:Genetics, Population; D005838:Genotype; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D007199:Indians, South American / Q000235:genetics; D007564:Japan / Q000208:ethnology; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D019713:Receptors, CCR5 / Q000235:genetics*
chemical_list: D018925:Chemokines; D019713:Receptors, CCR5