[Different expression of chaperone interacting protein in normal, scar and chronic ulcer tissues and its relationship with wound healing].
OBJECTIVE
To explore the expression characteristics of chaperone interacting protein (CHIP) in normal, scar and chronic ulcer tissues and its relationship with wound healing.


METHODS
Twenty biopsies including scar tissues (n = 8), chronic ulcer tissues (n = 4) and normal tissues (n = 8) were used in this study. The immunohistochemical staining (power vision two-step histo-staining reagent) was used to explore the amount and expression characteristics of such protein.


RESULTS
The positive expression of CHIP was observed in fibroblasts, endothelial cells and epidermal cells in dermis and epidermis. It was not seen in inflammatory cells. The expression amount of CHIP in scar tissues, chronic ulcer tissues and normal tissues was 89%, 83% and 17% respectively.


CONCLUSIONS
Although the function of CHIP is not fully understood at present, the fact that this protein is expressed only at the mitogenic cells indicates that it may be involved in mitogenic regulation during wound healing.
Fu
Xiaobing
X
Key Research Laboratory of Wound Repair of PLA, 304th Clinical Department, General Hospital of PLA, Beijing, 100037, PR China. fuxb@cgw.net.cn
Zhang
Hui
H
Xu
Xialian
X
Sun
Tongzhu
T
Chang
Zhijie
Z
D002908:Chronic Disease; D017439:Cicatrix, Hypertrophic / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018832:Molecular Chaperones / Q000378:metabolism; D012867:Skin / Q000378:metabolism / Q000473:pathology; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014456:Ulcer / Q000378:metabolism* / Q000473:pathology; D014945:Wound Healing / Q000502:physiology*
D018832:Molecular Chaperones; C467728:STUB1 protein, human; D044767:Ubiquitin-Protein Ligases