Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage "in cellulo".
The synthesis and photophysical characterisation are reported of a series of cationic, neutral and anionic europium and terbium complexes based on structurally related, nonadentate ligands based on the cyclen macrocycle. Each complex incorporates a tetraazatriphenylene moiety and overall absolute emission quantum yields are in the range 15-40% in aerated aqueous media. Dynamic quenching of the lanthanide excited state occurs with electron-rich donors, e.g. iodide, ascorbate and urate, and a mechanistic interpretation is put forward involving an electron transfer process. The cationic lanthanide complexes are taken up by NlH/3T3 cells and tend to localise inside the cell nucleus.
Poole
Robert A
RA
Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK.
Bobba
Gabriella
G
Cann
Martin J
MJ
Frias
Juan-Carlos
JC
Parker
David
D
Peacock
Robert D
RD
D000818:Animals; D007700:Kinetics; D028581:Lanthanoid Series Elements / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells / Q000648:ultrastructure; D010618:Phenanthrolines / Q000737:chemistry* / Q000378:metabolism
D028581:Lanthanoid Series Elements; D010618:Phenanthrolines