Analysis of factors that influence survival with post-transplant lymphoproliferative disorder in renal transplant recipients: the Israel Penn International Transplant Tumor Registry experience.
Significant mortality is associated with post-transplant lymphoproliferative disorder (PTLD) in kidney transplant recipients (KTX). Univariate/multivariate risk factor survival analysis of US PTLD KTX reported to Israel Penn International Transplant Tumor Registry from November 1968 to January 2000 was performed. PTLD presented 18 (median) (range 1-310) months in 402 KTX. Death rates were greater for those diagnosed within 6 months (64%) versus beyond 6 months (54%, p = 0.04). No differences in death risk for gender, race, immunosuppression, EBV, B or T cell positivity were identified. Death risk increased for multiple versus single sites (73% vs. 53%, hazards ratio (HR) 1.4). A 1-year increase in age increased HR for death by 2%. Surgery was associated with increased survival (55% vs. 0% without surgery) (p < 0.0001). Patients with allograft involvement, treated with transplant nephrectomy alone (n = 20), had 80% survival versus 53% without allograft removal (n = 15) (p < 0.001). Overall survival was 69% for allograft involvement alone versus 36% for other organ involvement plus allograft (n = 19 alive) (p < 0.0001). Death risk was greater for multiple site PTLD and increasing age, and risks were additive. Univariate analysis identified increased death risk for those not receiving surgery, particularly allograft involvement alone.
Trofe
Jennifer
J
Israel Penn International Transplant Tumor Registry, Division of Transplantation, University of Cincinnati, Cincinnati, OH, USA. jennifer.trofe@uphs.upenn.edu
Buell
Joseph F
JF
Beebe
Thomas M
TM
Hanaway
Michael J
MJ
First
M Roy
MR
Alloway
Rita R
RR
Gross
Thomas G
TG
Succop
P
P
Woodle
E Steve
ES
D006084:Graft Rejection / Q000517:prevention & control; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008232:Lymphoproliferative Disorders / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy; D012042:Registries; D013534:Survival; D016019:Survival Analysis