Biphasic decline of CD4 cell count during scheduled treatment interruptions.
In 115 patients whose scheduled treatment interruptions (STI) lasted 24 weeks, the CD4 cell count declined by a median of 30 cells/ml/week during the first 4 weeks, compared with 3 cells/ml/week during the next 20 weeks. In multivariate regression, a pronounced early fall in CD4 cells correlated with a higher CD4 cell count at the start of STI, with more gain in CD4 cells during antiretroviral treatment preceding STI, and with a higher viral load at week 4.
Fagard
Catherine
C
University Hospital, Geneva, Switzerland, and the Swiss HIV Cohort Study.
Bandelier
Cédric Y
CY
Ananworanich
Jintanat
J
Le Braz
Michelle
M
Günthard
Huldrych
H
Perneger
Thomas
T
García
Felipe
F
Hirschel
Bernard
B
D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D018791:CD4 Lymphocyte Count; D004334:Drug Administration Schedule; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D006801:Humans; D011446:Prospective Studies; D019562:Viral Load
D019380:Anti-HIV Agents