title: Low incidence of vascular complications in patients with diabetes mellitus associated with liver cirrhosis as compared with type 2 diabetes mellitus.
abstract: We compared clinical features and vascular complications of patients with diabetes mellitus associated with liver cirrhosis versus patients with type 2 diabetes mellitus. Subjects were 19 patients (LC-DM group) in whom diabetes was diagnosed after development of liver cirrhosis. Control consisted of 38 patients with type 2 diabetes (T2DM group) matched for sex, age, duration of diabetes, body mass index, treatment, and degree of glycemic control, which was determined by glycoalbumin. The LC-DM group had significantly more smokers, higher serum insulin levels, more insulin resistance calculated by homeostasis model assessment, lower blood counts (white and red blood cells, hemoglobin, and platelets), and lower serum levels of total cholesterol, triglyceride, low density lipoprotein cholesterol and lipoprotein (Lp)(a) than the T2DM group. The incidence of diabetic retinopathy and cerebrovascular disease was significantly lower in the LC-DM group compared to the T2DM group. Logistic regression analysis indicated that Lp(a) and the diabetes duration were significant predictors for the retinopathy, while Lp(a) was a significant predictor for the cerebrovascular complication. In diabetes associated with liver cirrhosis, the incidence of diabetic retinopathy and cerebrovascular disease is lower than in type 2 diabetes mellitus in this study, probably because of lower levels of serum Lp(a).
authors.affiliation: Department of Diabetes and Metabolism, School of Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan.
authors.forename: Fumikado
authors.initials: F
authors.lastname: Fujiwara
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Ishii
authors.forename: Haruhito
authors.initials: H
authors.lastname: Taneichi
authors.forename: Masanori
authors.initials: M
authors.lastname: Miura
authors.forename: Makiko
authors.initials: M
authors.lastname: Toshihiro
authors.forename: Noriko
authors.initials: N
authors.lastname: Takebe
authors.forename: Wataru
authors.initials: W
authors.lastname: Ishida
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Akinobu
authors.initials: A
authors.lastname: Kato
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Jo
authors.initials: J
authors.lastname: Satoh
mesh_terms: D000368:Aged; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000453:epidemiology* / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D015994:Incidence; D050356:Lipid Metabolism; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
chemical_list: D005947:Glucose