title: Fine-needle aspiration cytology of pleomorphic hyalinized angiectatic tumor: A case report.
abstract: Pleomorphic hyalinized angiectatic tumor (PHAT) of soft parts is a neoplasm characterized by spindle and pleomorphic cells associated with an angiectatic vasculature. We describe the cytological findings of a fine-needle aspiration biopsy (FNAB) from the right medial knee of a 45-yr-old woman. The aspirate material was entirely submitted in Cytolit solution. The specimen was moderately cellular and was comprised of spindle cells in a background of fibrinous material. The cells varied from small, bland spindle cells with a fine chromatin pattern and inconspicuous nucleoli to larger pleomorphic cells with coarser chromatin and occasional intranuclear inclusions. Most of the cells were arranged singly with sporadic small cluster formation with indistinct cell borders. Rare mononuclear inflammatory cells morphologically compatible with mast cells were identified. The differential diagnosis include solitary fibrous tumor (SFT) and ancient schwannoma, which also shows fibrous-like material and spindle cells that may have intranuclear inclusions.
authors.affiliation: Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, USA. lino@mskcc.org
authors.forename: Oscar
authors.initials: O
authors.lastname: Lin
authors.forename: John P
authors.initials: JP
authors.lastname: Crapanzano
mesh_terms: D044963:Biopsy, Fine-Needle; D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007717:Knee / Q000473:pathology*; D008875:Middle Aged; D009442:Neurilemmoma / Q000175:diagnosis / Q000473:pathology*