title: The use of clonidine for severe and intractable sleep problems in children with neurodevelopmental disorders--a case series.
abstract: This paper reports on the use of clonidine for the treatment of severe sleep problems associated with behavioural difficulties in children with neurodevelopmental disabilities. Data were obtained from reviewing the case notes of a series of six children with neurodevelopmental disorders of different nature and severity, presenting with problematic sleep. All children in this group showed maintained improvements in their sleep pattern following the use of clonidine with only mild side-effects reported.
authors.affiliation: South West London & St. George's Mental Health NHS Trust, Adolescent Assertive Outreach Team, ASH Corridor, Springfield Hospital, Tooting, London SW17 7DJ, UK. antoingrassia@yahoo.co.uk
authors.forename: Antonina
authors.initials: A
authors.lastname: Ingrassia
authors.forename: Jeremy
authors.initials: J
authors.lastname: Turk
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications* / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D002648:Child; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D002658:Developmental Disabilities / Q000150:complications* / Q000503:physiopathology*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D003000:Clonidine