title: Coxib toxicity: a likely class effect.
abstract: All coxibs appear to increase the risk of cardiovascular events. In Canada, widespread prescription of rofecoxib and celecoxib was followed by an increase in hospital admissions for gastrointestinal haemorrhage.
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000139:chemically induced; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D004311:Double-Blind Method; D064420:Drug-Related Side Effects and Adverse Reactions; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006801:Humans; D007783:Lactones / Q000009:adverse effects; D015201:Meta-Analysis as Topic; D011720:Pyrazoles / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic; D012306:Risk
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007783:Lactones; D011720:Pyrazoles