The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria.
OBJECTIVE
We assessed the disposition of oral amodiaquine (AQ) and CYP2C8 polymorphism in 20 children with falciparum malaria.


METHODS
AQ and DEAQ concentrations were determined with SPE-HPLC method. CYP2C8 genotypes were assessed by PCR-RFLP method.


RESULTS
AQ was not detectable beyond day 3 postdose. Cmax for DEAQ was reached in 3.0 days. The mean values for t1/2, MRT, and AUCtotal were 10.1 days, 15.5 days and 4512.6 microg l(-1) day, respectively. All the children were CYP2C8* homozygous.


CONCLUSIONS
Our data are consistent with those previously reported, and the AQ regimen seems pharmacokinetically adequate in the absence of CYP2C8 polymorphism.
Hombhanje
F W
FW
School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea. hombanfr@upng.ac.pg
Hwaihwanje
I
I
Tsukahara
T
T
Saruwatari
J
J
Nakagawa
M
M
Osawa
H
H
Paniu
M M
MM
Takahashi
N
N
Lum
J K
JK
Aumora
B
B
Masta
A
A
Sapuri
M
M
Kobayakawa
T
T
Kaneko
A
A
Ishizaki
T
T
D000284:Administration, Oral; D000655:Amodiaquine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000962:Antimalarials / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D065727:Cytochrome P-450 CYP2C8; D005838:Genotype; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000378:metabolism*; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length
D000962:Antimalarials; D000655:Amodiaquine; D001189:Aryl Hydrocarbon Hydroxylases; C450259:CYP2C8 protein, human; D065727:Cytochrome P-450 CYP2C8