[Analysis on the characteristics of blood serum Ab-IgG detective result of severe acute respiratory syndrome patients in Guangzhou, China].
OBJECTIVE
To probe blood serum Ab-IgG characteristics of severe acute respiratory syndrome (SARS) patients in Guangzhou and investigate the related factors.


METHODS
The serum of such population diagnosed as SARS convalescent patients, non-SARS patients, family consanguineous contraction persons, wild animal and vegetable salesman and community common people was collected. The lab detective method of ELISA was adopted for these serum samples. And the epidemic investigations for the SARS patients were also carried out.


RESULTS
Of these populations, the detective rate of Ab-IgG for the clinic diagnosed SARS patients, which was 53.7%; That for the wild animal salesman and community common people were 16.7% and 0.9%, respectively. Among the clinic diagnosed SARS patients, the positive antibody detective rate was 90.4% for those which had specific contact history or infectivity, which was higher than that for other population. Among the specific contact history or infectivity cases, the antibody positive rate for the young and the old was lower than that for the adult. Meanwhile the difference did not exist among other cases. The antibody positive rate was identical between the male and the female. And the antibody detective rate was decreased by the month.


CONCLUSIONS
As a whole SARS-CoV Ab-IgG detective rate for the clinic diagnosed SARS patients was 53.7% only. The reasons for that mainly lie in the wrong clinic diagnosis besides these factors such as age, hormone use and reagent and so on. The combination of lab detection results and epidemic investigation was propitious to the diagnosis veracity. It was impossible for the sub-clinic infection of SARS-CoV virus. The importance in the virus transmitting course need to be further studied.
Du
Lin
L
Guangzhou Center for Disease Control and Prevention, Guangzhou 510080, China.
Qiu
Ji-chun
JC
Wang
Ming
M
Zhou
Duan-hua
DH
Liu
Xiao-ning
XN
Gao
Yang
Y
Liu
Yu-fei
YF
DI
Biao
B
He
Li-juan
LJ
Tai
Peng-zhe
PZ
Liu
Wei-si
WS
Zhou
Xiu-zhen
XZ
Pan
Bing-ying
BY
Zou
Xiao-zhong
XZ
Xu
Hui-fang
HF
Mo
Rong-sen
RS
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology*; D016036:Seroepidemiologic Studies; D045169:Severe Acute Respiratory Syndrome / Q000453:epidemiology* / Q000276:immunology
D000914:Antibodies, Viral; D007074:Immunoglobulin G