title: Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression.
abstract: In the present study, cyclin I protein expression in 114 invasive human breast cancers was correlated with cell cycle and angiogenesis-related proteins and clinico-pathological data. A strong association was found between cytoplasmic cyclin I staining and VEGF (p = 0.001) as well as the VEGF receptor KDR (p = 0.001), suggesting a link between cyclin I and angiogenesis.
authors.affiliation: Division of Pathology, Department of Laboratory Medicine, U-MAS, Lund University, Malmö, Sweden.
authors.forename: Göran
authors.initials: G
authors.lastname: Landberg
authors.forename: Kristina
authors.initials: K
authors.lastname: Nilsson
authors.forename: Karin
authors.initials: K
authors.lastname: Jirström
authors.forename: Lisa
authors.initials: L
authors.lastname: Rydén
authors.forename: Richard
authors.initials: R
authors.lastname: Kitching
authors.forename: Angelika M
authors.initials: AM
authors.lastname: Burger
authors.forename: Arun
authors.initials: A
authors.lastname: Seth
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001943:Breast Neoplasms / Q000378:metabolism*; D056749:Cyclin I; D016213:Cyclins / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007124:Immunoenzyme Techniques; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*
chemical_list: C534756:CCNI protein, human; D056749:Cyclin I; D016213:Cyclins; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2