[Antiviral activity of vegetable triterpens, their derivatives and ribavirin phosphonates].
The purpose of the study was to investigate, in the Vero cell culture, the antiviral activity of vegetable tritrpens derivatives and ribavirin analogues against the viruses of measles, herpes simple (type 1), cytomegaloviruses and filoviruses. The toxicity and antiviral activity of compounds were determined after coloring of cells with crystal violate. Additionally, the combined action of triterpens' derivatives and ribavirin was investigated. The studied compounds showed relatively low antiviral activity, nonetheless, further research of vegetable triterpens and their derivatives as well as ribavirin analogues would be promising.
Il'icheva
T N
TN
Kulishova
L A
LA
Shul'ts
E E
EE
Petrenko
N I
NI
Uzenkova
N V
NV
Ias'ko
M V
MV
Serova
O A
OA
Volkov
G N
GN
Belanov
E F
EF
Tolstikov
G A
GA
Pokrovskiĭ
A G
AG
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003124:Colorimetry; D003587:Cytomegalovirus / Q000187:drug effects* / Q000254:growth & development; D016563:Filoviridae / Q000187:drug effects* / Q000254:growth & development; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000196:embryology; D018103:Morbillivirus / Q000187:drug effects* / Q000254:growth & development; D012254:Ribavirin / Q000494:pharmacology*; D014315:Triterpenes / Q000494:pharmacology*; D014709:Vero Cells
D000998:Antiviral Agents; D014315:Triterpenes; D012254:Ribavirin