Flavonoids from Punica granatum--potential antiperoxidative agents.
Fractions rich in flavonoids obtained from the fruits of Punica granatum extract, orally administered to rats at dose of 10 mg kg(-1) day(-1), showed potential antiperoxidative effect. Concentrations of malondialdehyde, hydroperoxides and conjugated dienes were significantly decreased in liver while the activities of the enzymes catalase, superoxide dismutase (SOD), glutathione peroxidase and glutathione reductase showed significant elevation. Concentrations of glutathione in the tissues were also increased.
Sudheesh
S
S
Department of Biochemistry, University of Kerala, Thiruvananthapuram, 695581 India.
Vijayalakshmi
N R
NR
D000284:Administration, Oral; D000818:Animals; D047309:Flavones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005638:Fruit; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D029561:Lythraceae; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
D047309:Flavones; D010936:Plant Extracts; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase