Fas polymorphisms are associated with the presence of anti-ganglioside antibodies in Guillain-Barre syndrome.
Polymorphisms in genes involved in regulation of immune homeostasis may be a susceptibility factor in the induction of cross-reactive anti-ganglioside antibodies after infection in patients with Guillain-Barre syndrome (GBS). In this study we assessed whether polymorphisms in the promoter region of Fas and FasL and sFas and sFasL are related to GBS or its distinct clinical or serological subgroups. We show that the A(-670)G SNP in the promoter region of Fas and high levels of sFas are associated with the presence of anti-ganglioside antibodies, suggesting that Fas-FasL interaction is involved in the production of cross-reactive antibodies in GBS.
Geleijns
Karin
K
Department of Neurology, Erasmus MC, Dr. Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands. c.geleijns@erasmusmc.nl
Laman
Jon D
JD
van Rijs
Wouter
W
Tio-Gillen
Anne P
AP
Hintzen
Rogier Q
RQ
van Doorn
Pieter A
PA
Jacobs
Bart C
BC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000097:blood* / Q000276:immunology; D002648:Child; D016001:Confidence Intervals; D053222:Fas Ligand Protein; D005260:Female; D005732:Gangliosides / Q000097:blood / Q000276:immunology*; D005787:Gene Frequency; D005838:Genotype; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012720:Severity of Illness Index; D019014:fas Receptor / Q000097:blood / Q000235:genetics*
D000906:Antibodies; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D005732:Gangliosides; D008562:Membrane Glycoproteins; D019014:fas Receptor