title: Development of a harmonized method for the profiling of amphetamines. II. Stability of impurities in organic solvents.
abstract: The present study focused on the stability of 22 amphetamine impurities dissolved in six organic solvents: isooctane, toluene, ethanol, dichloromethane, ethyl acetate, and diethyl ether. The aim was to find the most inert, and thereby most suitable, solvent for amphetamine profiling. Mixtures of the impurities were prepared in the different solvents, and changes in the concentrations of the individual compounds over-time were monitored by gas chromatographic analysis after 0, 4, 12, 24, 48, and 96 h. Isooctane and toluene provided the most inert conditions, although, a few of the impurities were insufficiently stable in these two solvents. The present experiments were performed as a part of the development of a harmonized method for profiling of amphetamine. The results can be used to support the choice of organic solvents for sample preparation. They also provide information about the stability of the impurities that are found in profiles of illicit amphetamine. This is essential due to the fact, that unstable compounds can have a negative influence on the comparison of profiles.
authors.affiliation: Crime Laboratory, National Bureau of Investigation, P.O. Box 285, SF-01301 Vantaa, Finland.
authors.forename: Laura
authors.initials: L
authors.lastname: Aalberg
authors.forename: Kjell
authors.initials: K
authors.lastname: Andersson
authors.forename: Christina
authors.initials: C
authors.lastname: Bertler
authors.forename: Michael D
authors.initials: MD
authors.lastname: Cole
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Finnon
authors.forename: Henk
authors.initials: H
authors.lastname: Huizer
authors.forename: Kaisa
authors.initials: K
authors.lastname: Jalava
authors.forename: Elisabet
authors.initials: E
authors.lastname: Kaa
authors.forename: Eric
authors.initials: E
authors.lastname: Lock
authors.forename: Alvaro
authors.initials: A
authors.lastname: Lopes
authors.forename: Anneke
authors.initials: A
authors.lastname: Poortman-van der Meer
authors.forename: Erkki
authors.initials: E
authors.lastname: Sippola
authors.forename: Johan
authors.initials: J
authors.lastname: Dahlén