DNA repair gene XRCC1 Arg399Gln polymorphism is associated with increased risk of uterine leiomyoma.
BACKGROUND
DNA repair gene XRCC1 Arg399Gln polymorphism has been associated with the risk of several human tumours. In the present study we investigated whether the XRCC1 polymorphism is related to the risk of uterine leiomyoma, the most common neoplasm of the female genital tract.


METHODS
Three hundred and twenty-seven patients with uterine leiomyoma and 197 normal controls were enrolled, and XRCC1 genotyping was determined by PCR and restriction fragment length polymorphism.


RESULTS
The proportions of individuals homozygous for 399Arg allele, heterozygous and homozygous for the 399Gln allele were 85.8%, 13.7% and 0.5% among the control group, and 46.2%, 53.2% and 0.6% in those with leiomyoma (P < 0.001), respectively. Logistic regression analysis (after adjusting for age, parity, menarche age and body mass index) showed a significant increased risk of uterine leiomyoma in women with the Arg/Gln genotype versus the Arg/Arg genotype (odds ratio 6.79; 95% confidence interval 4.20-10.99; P < 0.001).


CONCLUSIONS
In Korean women, the 399Gln polymorphism of XRCC1 is associated with an increased risk of uterine leiomyoma.
Jeon
Yong-Tark
YT
Departments of Obstetrics and Gynecology, College of Medicine, Seoul National University, Jongno-Gu, Seoul, Korea.
Kim
Jae Weon
JW
Park
Noh-Hyun
NH
Song
Yong-Sang
YS
Kang
Soon-Beom
SB
Lee
Hyo-Pyo
HP
D000328:Adult; D001120:Arginine / Q000235:genetics; D044466:Asian People / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005973:Glutamine / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D007723:Korea; D007889:Leiomyoma / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014594:Uterine Neoplasms / Q000235:genetics*; D000076105:X-ray Repair Cross Complementing Protein 1
D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D005973:Glutamine; D001120:Arginine