Dual functions of murine gammadelta cells in inflammation and autoimmunity in coxsackievirus B3-induced myocarditis: role of Vgamma1+ and Vgamma4+ cells.
Coxsackieviruses are a cause of clinical myocarditis. Both virus replication and host defense mechanisms, including virus-induced autoimmunity, mediate heart injury and cardiac dysfunction. Vgamma4+ cells kill infected cardiocytes and virus-specific CD4+ Th2 cells through Fas-dependent apoptosis and CD1d. The CD4+ Th1 response is necessary for activation of the autoimmune CD8+ T cells, which kill uninfected cardiocytes through perforin-dependent mechanisms.
Huber
S A
SA
Department of Pathology, University of Vermont, Burlington, VT, USA. Sally.Huber@uvm.edu
Born
Willi
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O'Brien
Rebecca
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D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D002311:Cardiomyopathy, Dilated / Q000276:immunology / Q000821:virology; D003384:Coxsackievirus Infections / Q000276:immunology*; D029822:Enterovirus B, Human; D051379:Mice; D009205:Myocarditis / Q000276:immunology* / Q000821:virology*; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology*