title: [Plasma level of macrophage-colony stimulating factor (M-CSF) in the course of breast cancer treatment].
abstract: Macrophage-colony stimulating factor (M-CSF) is one of the glycoproteins called colony-stimulating factors (CSF). Some clinical investigations have shown an autologous production of M-CSF in various human cell lines in vitro and by tumour cells in vivo. We have investigated the plasma level of M-CSF and commonly accepted tumour marker, such as CA 15-3 in the plasma of 44 patients with breast cancer. Blood was taken before and in 30 and 180 days after surgery. The patients were divided into two groups: A (stage 1) and B (stage 11). M-CSF was determined using enzyme-linked immunosorbent assay (ELISA), CA 15-3 was measured by microparticle enzyme immunoassay (MEIA). M-CSF plasma levels were significantly higher in breast cancer patients before and after surgery comparing to the control group. The M-CSF level was higher in group B (11 stage) compared to the group A (I stage). These results suggest the potential role of M-CSF in the diagnostics and monitoring of breast cancer chemotherapy.
authors.affiliation: Zakład Diagnostyki Biochemicznej AM w Białymstoku.
authors.forename: Slawomir
authors.initials: S
authors.lastname: Lawicki
authors.forename: Jacek
authors.initials: J
authors.lastname: Omyła
authors.forename: Barbara
authors.initials: B
authors.lastname: Mroczko
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Czygier
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D009367:Neoplasm Staging; D012372:ROC Curve; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; D018396:Mucin-1; D016173:Macrophage Colony-Stimulating Factor