[A novel orthopaedic biodegradable polymer and its biocompatibility].
Copolymer of polycaprolactone (PCL) and polylactic acid (PLA) was synthesized and catalyzed using Y (CF3COO)3/AL (I-Bu)3. The biocompatibility was evaluated by means of biochemistry, immunocytochemistry, and by cytotoxity test. This novel orthopedic biodegradable polymer can serve as an ideal orthopedic biodegradable implants, and adjustment of molecular weight and ratio of polymers can control its degradation period.
Liu
Jianguo
J
Department of Orthopedic Surgery, The First Teaching Hospital of JiLin University, Changchun 130021, China.
Qi
Xin
X
Guan
Jikui
J
Xu
Xinxiang
X
Chen
Xuesi
X
Jing
Xiabin
X
D020341:Absorbable Implants; D000818:Animals; D018786:Bone Substitutes; D002384:Catalysis; D005260:Female; D019344:Lactic Acid / Q000737:chemistry*; D008297:Male; D008422:Materials Testing; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D018786:Bone Substitutes; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; D019344:Lactic Acid; C033616:poly(lactide)