title: Indole and carbazole alkaloids from Glycosmis montana with weak anti-HIV and cytotoxic activities.
abstract: A diprenylated indole, (E)-3-(3-hydroxymethyl-2-butenyl)-7-(3-methyl-2-butenyl)-1H-indole (1), and six known carbazole alkaloids were isolated from the twigs and leaves of Glycosmis montana Pierre (Rutaceae). Their structures were determined on the basis of analysis of spectral evidence including 1D and 2D NMR and MS. The alkaloids (1-3) exhibited weak to moderate take in vitro inhibitory activity against HIV replication in C8166 cells, and they (as well as carbalexine A and B) had cytotoxic activity against the human leukaemia cell line CCRF-CEM.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongton, Kunming, Yunnan 650204, PR China.
authors.forename: Junsong
authors.initials: J
authors.lastname: Wang
authors.forename: Yongtang
authors.initials: Y
authors.lastname: Zheng
authors.forename: Thomas
authors.initials: T
authors.lastname: Efferth
authors.forename: Ruirui
authors.initials: R
authors.lastname: Wang
authors.forename: Yuemao
authors.initials: Y
authors.lastname: Shen
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Hao
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007938:Leukemia / Q000188:drug therapy; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D002227:Carbazoles; D007211:Indoles