title: Cognitive impairment associated with major depression following mild and moderate traumatic brain injury.
abstract: Traumatic brain injury (TBI) and major depression are neuropsychiatric conditions that have been associated with cognitive dysfunction. The aim of this study was to explore the relationship between major depression and cognitive impairment following mild and moderate TBI. Seventy-four TBI patients were assessed for the presence of major depression using the Structured Clinical Interview for the DSM-IV and completed a neurocognitive assessment battery. Subjects with major depression (28.4%), compared to those without, were found to have significantly lower scores on measures of working memory, processing speed, verbal memory and executive function. Potential mechanisms and implications for treatment are discussed.
authors.affiliation: Department of Psychiatry and Traumatic Brain Injury Clinic, FG37, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, 2075 Bayview Ave., Toronto, ON, M4N 3M5, Canada. Mark.Rapoport@sw.ca
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Rapoport
authors.forename: Scott
authors.initials: S
authors.lastname: McCullagh
authors.forename: Prathiba
authors.initials: P
authors.lastname: Shammi
authors.forename: Anthony
authors.initials: A
authors.lastname: Feinstein
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000453:epidemiology / Q000523:psychology*; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology / Q000523:psychology*; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000209:etiology / Q000523:psychology*; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data