title: Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation.
abstract: The products of nonenzymatic glycation and oxidation of proteins and lipids, the advanced glycation end products (AGEs), accumulate in a wide variety of environments. AGEs may be generated rapidly or over long times stimulated by a range of distinct triggering mechanisms, thereby accounting for their roles in multiple settings and disease states. A critical property of AGEs is their ability to activate receptor for advanced glycation end products (RAGE), a signal transduction receptor of the immunoglobulin superfamily. It is our hypothesis that due to such interaction, AGEs impart a potent impact in tissues, stimulating processes linked to inflammation and its consequences. We hypothesize that AGEs cause perturbation in a diverse group of diseases, such as diabetes, inflammation, neurodegeneration, and aging. Thus, we propose that targeting this pathway may represent a logical step in the prevention/treatment of the sequelae of these disorders.
authors.affiliation: Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Ravichandran
authors.initials: R
authors.lastname: Ramasamy
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Vannucci
authors.forename: Shirley Shi Du
authors.initials: SS
authors.lastname: Yan
authors.forename: Kevan
authors.initials: K
authors.lastname: Herold
authors.forename: Shi Fang
authors.initials: SF
authors.lastname: Yan
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Schmidt
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D048909:Diabetes Complications / Q000503:physiopathology*; D017127:Glycation End Products, Advanced / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D051379:Mice; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D018384:Oxidative Stress; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000502:physiology*
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic