[Hormone replacement therapy and bone metabolic marker].
With the advent of newly developed sensitive markers of bone turnover, initial values of biochemical markers were reported to be significantly higher in those that gained bone than in those that lost bone in hormone replacement therapy (HRT) . Bone resorption markers reach nadir 3 to 6 months after the start of HRT whereas bone formation markers reach nadir 6 month after the treatment. The greater the decrease in biochemical markers is, the larger the bone mass can be expected to be obtained with HRT.
Gorai
I
I
Department of Obsterics and Gynecology, Yokohama City University School of Medicine.