title: Lack of efficacy of tacrolimus ointment 0.1% for treatment of hemodialysis-related pruritus: a randomized, double-blind, vehicle-controlled study.
abstract: Pruritus is a common and disabling symptom for patients undergoing hemodialysis. Many topical and systemic treatments have been used for uremic pruritus, mostly in anecdotal reports. A recent case series demonstrated that topical tacrolimus ointment 0.03% had a significant antipruritic effect for patients with uremia. In an attempt to confirm these findings, we conducted a randomized, double-blind, vehicle-controlled study to assess the efficacy of tacrolimus ointment 0.1% for the treatment of hemodialysis-related pruritus. The results of this study do not demonstrate that tacrolimus ointment 0.1% is more effective than vehicle in relieving uremic pruritus.
authors.affiliation: Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Duque
authors.forename: Gil
authors.initials: G
authors.lastname: Yosipovitch
authors.forename: Alan B
authors.initials: AB
authors.lastname: Fleischer
authors.forename: Joy
authors.initials: J
authors.lastname: Willard
authors.forename: Barry I
authors.initials: BI
authors.lastname: Freedman
mesh_terms: D000287:Administration, Topical; D000368:Aged; D004311:Double-Blind Method; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009824:Ointments; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D006435:Renal Dialysis / Q000009:adverse effects*; D016559:Tacrolimus / Q000008:administration & dosage / Q000627:therapeutic use*; D014511:Uremia / Q000150:complications
chemical_list: D007166:Immunosuppressive Agents; D009824:Ointments; D016559:Tacrolimus