title: [Successful treatment with etoposide by oral administration for recurrence of gastric diffuse large B-cell lymphoma after surgical resection--a case report].
abstract: A 64-year-old woman, who had been treated for gastric diffuse large B-cell lymphoma (DLBCL) by total gastrectomy and received 3 courses of CHOP therapy at 61 years of age, was diagnosed with recurrence of DLBCL in the small intestine. After the small intestinal tumor was resected, multiple metastases were found in the liver. Because intensive chemotherapy was difficult for her poor performance status, 50 mg of etoposide daily by oral was administered for 21 consecutive days. After one course of chemotherapy, liver metastases and lymph node swelling almost disappeared without severe adverse effects, and after five courses she achieved complete remission. Though DLBCL invaded the central nervous system, the abdominal regions had been free from recurrence for 12 months. This case report suggests that oral etoposide therapy is useful for gastrointestinal DLBCL which has metastasized to the liver.
authors.affiliation: Division of Hematology and Immunology, Kanazawa Medical University.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Fukushima
authors.forename: Toshioki
authors.initials: T
authors.lastname: Sawaki
authors.forename: Kumiko
authors.initials: K
authors.lastname: Shimoyama
authors.forename: Hiromi
authors.initials: H
authors.lastname: Karasawa
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Masaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawabata
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Ogawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Wano
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hirose
authors.forename: Susumu
authors.initials: S
authors.lastname: Sugai
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Sutoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kojima
mesh_terms: D000284:Administration, Oral; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007078:Ileal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008113:Liver Neoplasms / Q000556:secondary; D016393:Lymphoma, B-Cell / Q000188:drug therapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy*; D008875:Middle Aged; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide