title: First approach to the frondosin C ring system via a tandem cyclization/Claisen rearrangement sequence.
abstract: [reaction: see text] A one-pot tandem 5-exo cyclization/Claisen rearrangement strategy is utilized as the key step in the straightforward construction of the tetracyclic ring system of frondosin C. This reaction is done under microwave irradiation in the presence of catalytic MeLi.
authors.affiliation: Department of Chemistry, Connecticut College, 270 Mohegan Avenue, New London, Connecticut 06320, USA.
authors.forename: Isamir
authors.initials: I
authors.lastname: Martínez
authors.forename: Philip E
authors.initials: PE
authors.lastname: Alford
authors.forename: Timo V
authors.initials: TV
authors.lastname: Ovaska
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D015394:Molecular Structure
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D007202:Indicators and Reagents; C506349:frondosin C