[Inhibitory effects of bisphosphonate on vascular calcification].
Recently, it has been hypothesized that vascular calcification is an actively regulated process in which vascular smooth muscle cells (VSMCs) acquire osteoblast-like functions. Bisphosphonates prevent in vitro calcification of VSMCs and probably inhibit phosphate transport by sodium dependent phosphate transporter which plays a key role in VSMCs calcification. The effects of bisphosphonate on VSMCs have important implications for the future management of patients with vascular calcification.
Katsumata
Takashi
T
Discovery Res. Lab.II, Research Div., Sumitomo Pharmaceuticals Co. Ltd.