Parkinson's disease: from causes to mechanisms.
Parkinson's disease (PD) is a common age-related, progressive neurodegenerative disease of unknown etiology. Environmental factors have long been suspected to participate in the pathogenesis of PD due to the existence of neurotoxins that preferentially damage the dopaminergic nigrostriatal pathway. In the past few years, novel insights into the degenerative process have been provided by the discovery of genes responsible for rare monogenic parkinsonian syndromes. Compelling evidence is accumulating, suggesting that the products of several of these genes can interact with environmental toxins and intervene in molecular pathways controlling the functional integrity of mitochondria.
Corti
Olga
O
INSERM U 289, hôpital de la Pitié-Salpêtrière, 47, bd de l'Hôpital, 75013 Paris, France.
Hampe
Cornelia
C
Darios
Frédéric
F
Ibanez
Pablo
P
Ruberg
Merle
M
Brice
Alexis
A
D003342:Corpus Striatum / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000473:pathology / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics; D010300:Parkinson Disease / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D013378:Substantia Nigra / Q000503:physiopathology; D051843:Synucleins; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
D009419:Nerve Tissue Proteins; D051843:Synucleins; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D004298:Dopamine