Transfusion for a patient of cis-AB blood type undergoing a redo cardiac operation.
cis-AB, a rare ABO genotype, is the result of a mutated gene resulting in dual specific hybrid enzymes. A single-point mutation reverses the specificity of human blood group B synthesizing galactosyltransferase. This may lead to misclassification in ABO grouping and adverse transfusion reactions. Recently, the authors experienced a case of a patient with cis-AB blood type undergoing pulmonary valve replacement and tricuspid valvuloplasty. We transfused the patient with Rh+ A packed red blood cell, fresh frozen plasma and platelet concentrates without any clinically significant transfusion reactions.
Yoon
S Z
SZ
Department of Anaesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, Korea.
Lee
H M
HM
Kim
H S
HS
Kim
S D
SD
Oh
A Y
AY
Kim
C S
CS
D000017:ABO Blood-Group System / Q000235:genetics*; D000293:Adolescent; D001788:Blood Grouping and Crossmatching; D001803:Blood Transfusion / Q000379:methods*; D005700:Galactosyltransferases / Q000235:genetics; D006330:Heart Defects, Congenital / Q000097:blood / Q000601:surgery*; D006801:Humans; D008297:Male; D017354:Point Mutation; D012086:Reoperation; D012204:Rh-Hr Blood-Group System
D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System; D005700:Galactosyltransferases; C023155:blood-group-substance alpha-D-galactosyltransferase