title: Persistent parvovirus-associated chronic fatigue treated with high dose intravenous immunoglobulin.
abstract: We report a 16-year-old boy with no evidence of immunodeficiency who had a 2-year history of chronic fatigue, low grade fever and slapped-cheek rash associated with chronic parvovirus B19 viremia. Prolonged intravenous immunoglobulin therapy resulted in resolution of his symptoms and viremia. Intravenous immunoglobulin may be useful in the resolution of parvovirus viremia regardless of immune status.
authors.affiliation: Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. smcghee@mednet.ucla.edu
authors.forename: Sean A
authors.initials: SA
authors.lastname: McGhee
authors.forename: Benjamin
authors.initials: B
authors.lastname: Kaska
authors.forename: Myron
authors.initials: M
authors.lastname: Liebhaber
authors.forename: E Richard
authors.initials: ER
authors.lastname: Stiehm
mesh_terms: D000293:Adolescent; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D015673:Fatigue Syndrome, Chronic / Q000150:complications / Q000175:diagnosis*; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D017992:Parvovirus / Q000302:isolation & purification*; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous