[The first experience with linezolide in treatment of nosocomial septic condition in premature neonates].
OBJECTIVE
Nosocomial infections caused by the coagulase-negative staphylococci are among the most frequent complications in an intensive care unit for neonates. The authors describe three cases of successful treatment of this complication in which the new antibiotic Linezolide was used.


METHODS
Analysis of three clinical cases.


METHODS
Mother and Child Care Institute, Prague.


METHODS
Description of cases of nosocomial sepsis in 3 immature neonates where the usual treatment of multiresistant strains of coagulase-negative staphylococci, based on the use of Vankomycin, was not successful.


CONCLUSIONS
Administration of Linezolide proved to be very effective in all of the described cases. In spite of the high effectiveness and relative safety of this preparation, its precise role in the treatment of infection-related complications caused by coagulase-negative staphylococci has not yet been established. For the time being, we recommend administering this preparation only in strictly indicated cases after the usual therapy fails.
Miletín
J
J
Ustav pro péci o matku a díte, Praha. miletin@yahoo.com
Melichar
J
J
Janota
J
J
Mikolágová
B
B
Jedlicková
A
A
Kucera
J
J
Cunát
V
V
Stranák
Z
Z
D000081:Acetamides / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003030:Coagulase / Q000378:metabolism; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D000069349:Linezolid; D023303:Oxazolidinones / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013210:Staphylococcus / Q000201:enzymology
D000081:Acetamides; D000900:Anti-Bacterial Agents; D003030:Coagulase; D023303:Oxazolidinones; D000069349:Linezolid