Conjunctival lymphoid hyperplasia presenting with bilateral panuveitis.
OBJECTIVE
To report on a case of bilateral conjunctival lymphoid hyperplasia presenting with bilateral panuveitis in a female patient.


METHODS
Observational case report.


METHODS
In this case excisional biopsy indicated lymphoid tissue. Immunohistochemistry showed a follicular architecture with appropriate zoning of B and T lymphocytes.


RESULTS
Causes of panuveitis were considered and excluded based on a detailed history, physical examination, and laboratory investigations. The bilateral panuveitis resolved on topical corticosteroids and visual acuity returned to normal.


CONCLUSIONS
Ocular adnexal lymphoproliferative lesions consist of a spectrum of disease entities, including reactive lymphoid hyperplasia, atypical lymphoid hyperplasia, and lymphoma. There are no established clinical criteria to differentiate between these lesions. This case highlights the importance of a thorough ophthalmic examination in these patients, as an intra-ocular inflammatory process may accompany the conjunctival findings. Furthermore, we advocate periodic follow-up examinations because of the small potential risk of developing ocular or systemic lymphoma in these patients.
Ioannidis
Alexander S
AS
Department of Ophthalmology, Royal Free Hospital, NHS Trust, London, United Kingdom. alexioannidis@hotmail.com
Rai
Poornima
P
Mulholland
Bridget
B
D001402:B-Lymphocytes / Q000473:pathology; D003229:Conjunctival Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004338:Drug Combinations; D005260:Female; D005477:Fluprednisolone / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D008875:Middle Aged; D009355:Neomycin / Q000627:therapeutic use; D015864:Panuveitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011112:Polymyxin B / Q000627:therapeutic use; D019310:Pseudolymphoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013601:T-Lymphocytes / Q000473:pathology
D004338:Drug Combinations; D005938:Glucocorticoids; C049064:Maxitrol; D005477:Fluprednisolone; D009355:Neomycin; D011112:Polymyxin B