[Drugs that modulate the cellular function of calcium ion].
Cytoplasmic Ca(2+) concentration is kept low level of about 10(-7)M. When Ca(2+) concentration increases by specific stimuli via opening of channel proteins, Ca(2+) binds to Ca(2+)-binding proteins, activating specific proteins, results in responding the stimuli. In this report, we summarize the effect of drugs, of which targets are the proteins above, including Ca(2+)-pump, ion exchanger, ion channels, calmodulin and calmodulin-binding proteins, and other Ca(2+) binding proteins.
Ishikawa
R
R
Department of pharmacology, Gunma University School of Medicine.
Kohama
K
K