What have we learnt about microarray analyses of atherogenesis?
OBJECTIVE
This review covers recent developments in microarray studies in the field of atherogenesis research.


RESULTS
During the past year microarrays have been applied to the analysis of pathogenic mechanisms of several atherosclerosis risk factors, including ageing, hypertension, obesity, and cytomegalovirus infection. In addition, gene expression patterns during the development of in-stent restenosis have been examined. Several studies have also explored the pleiotropic effects of statin therapy. As a technical improvement, the combination of laser microdissection with microarrays in human samples has been reported.


CONCLUSIONS
Microarray analyses have given important new information about atherogenesis. It is anticipated that microarray studies will significantly contribute to further discoveries in the field.
Tuomisto
Tiina T
TT
Department of Biotechnology and Molecular Medicine, AI Virtanen Institute, Kuopio University Hospital, Kuopio, Finland.
Ylä-Herttuala
Seppo
S
D000375:Aging / Q000235:genetics; D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics* / Q000378:metabolism; D002478:Cells, Cultured; D003586:Cytomegalovirus Infections / Q000235:genetics; D020869:Gene Expression Profiling; D006801:Humans; D006973:Hypertension / Q000235:genetics; D009765:Obesity / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D012307:Risk Factors