title: A case of rosiglitazone exposure in the second trimester of pregnancy.
abstract: OBJECTIVE
  Data about rosiglitazone use in pregnancy is limited. We aimed to present a pregnant woman who exposed to rosiglitazone in the second trimester and the fetal outcome.
  
  
  METHODS
  The case was a 42-year-old, multigravid Caucasian woman with a history of diabetes mellitus type II for 4 years prior to her current pregnancy. Her diabetes was managed by diet and exercise and she has not received any drug therapy until the 13th week of her sixth (present) and unplanned pregnancy. The case was exposed to rosiglitazone (4 mg/day) between 13th and 17th gestational weeks. After the diagnosis of pregnancy at the 17th week, rosiglitazone was stopped and insulin therapy was started. At the 37th week, she had a healthy male infant (4500 g, 50 cm). The baby was examined and no major or minor malformations were observed.
  
  
  CONCLUSIONS
  This is the first case present in the literature exposed to rosiglitazone in the second trimester of her pregnancy. The data from the present case may contribute to the existing limited knowledge about rosiglitazone in pregnancy.
authors.affiliation: Department of Pharmacology, School of Medicine, Karadeniz Technical University, TR-61187 Trabzon, Turkey.
authors.forename: Nuri Ihsan
authors.initials: NI
authors.lastname: Kalyoncu
authors.forename: Fusun
authors.initials: F
authors.lastname: Yaris
authors.forename: Cunay
authors.initials: C
authors.lastname: Ulku
authors.forename: Mine
authors.initials: M
authors.lastname: Kadioglu
authors.forename: Murat
authors.initials: M
authors.lastname: Kesim
authors.forename: Mesut
authors.initials: M
authors.lastname: Unsal
authors.forename: Mustafa
authors.initials: M
authors.lastname: Dikici
authors.forename: Ersin
authors.initials: E
authors.lastname: Yaris
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011254:Pregnancy in Diabetics / Q000188:drug therapy*; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone