title: [CD1 pathway and NK T cell activation to glycolipid antigens from Mycobacterium tuberculosis].
abstract: The aim of this review is to analyze the current state of our knowledge about cell surface molecules involved in glycolipid antigen presentation, named CD1 family. These proteins constitute a third class of antigen-presenting molecules. CD1 molecules develop diverse important immune functions in host defenses against microbial infections. In recent years these proteins have been involved in the generation of cell-mediated immune response against Mycobacterium tuberculosis. Here, we analyze relevant roles of CD1 proteins and glycolipid antigen-specific T cells.
authors.affiliation: Departamento de Bioquímica, Unidad de Investigación, Instituto Nacional de Enfermedades Respiratorias, Secretaria de Salud, México, DF. i_sadamx@yahoo.com.mx
authors.forename: Isabel
authors.initials: I
authors.lastname: Sada-Ovalle
authors.forename: Luis
authors.initials: L
authors.lastname: Torre-Bouscoulet
authors.forename: María del Carmen
authors.initials: Mdel C
authors.lastname: Jiménez-Martínez
authors.forename: Salvador
authors.initials: S
authors.lastname: Martínez-Cairo
authors.forename: Edgar
authors.initials: E
authors.lastname: Zenteno
authors.forename: Ricardo
authors.initials: R
authors.lastname: Lascurain
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology*; D018949:Antigens, CD1 / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006017:Glycolipids / Q000276:immunology*; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D018949:Antigens, CD1; D006017:Glycolipids; C072681:Mycobacterium tuberculosis antigens