title: [Serotonin syndrome: report of two cases and review of the literature].
abstract: BACKGROUND
  Serotonin is a neurotransmitter synthesized from tryptophan. It is implied in the regulation of mood, cognition, sleep cycle, synthesis of cerebrospinal fluid, and other processes. Generally, it is implied in human pathology by hypofunction. However, there is a complication of unknown incidence related to treatment with drugs that increase the stimulation of 5-HT1A serotonin receptors, called serotonin syndrome (SS). Clinically, it is characterised by the presence of a triad of mental and autonomic disorders, and motor hyperactivity. This entity has not biological markers and its diagnosis could be done verifying the proposed criteria.
  
  
  METHODS
  Two cases of SS are presented, one of them related to the combination of risperidone and sertraline, as first report in the literature. Both cases had a favourable outcome employing support measures.
  
  
  CONCLUSIONS
  The physiopathology, the diagnosis, the differential diagnosis, and the treatment are reviewed. We emphasize the potentially high frequency of this disorder, given the growing use of serotonin activity modifying drugs, and the typically benign course of the SS once the support measures are started.
authors.affiliation: Unidad de Neurología, Hospital Son Llàtzer, Palma de Mallorca. franciscoplus@hotmail.com
authors.forename: F J
authors.initials: FJ
authors.lastname: Alvarez-Pérez
authors.forename: M
authors.initials: M
authors.lastname: Roca
authors.forename: E
authors.initials: E
authors.lastname: Martorell
authors.forename: A M
authors.initials: AM
authors.lastname: Espino
authors.forename: M M
authors.initials: MM
authors.lastname: Usón
authors.forename: A
authors.initials: A
authors.lastname: Figuerola
authors.forename: J
authors.initials: J
authors.lastname: Ballabriga
mesh_terms: D000368:Aged; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000737:chemistry / Q000378:metabolism; D018967:Risperidone / Q000009:adverse effects / Q000627:therapeutic use; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D020230:Serotonin Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D020280:Sertraline / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D018967:Risperidone; D012701:Serotonin; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline