title: Soft-tissue sarcomas of the chest wall: prognostic factors.
abstract: OBJECTIVE
  To evaluate factors that are predictive of outcome for patients with chest wall soft-tissue sarcomas.
  
  
  METHODS
  A retrospective review of 55 surgically treated patients, from March 1964 to October 1996.
  
  
  RESULTS
  The median age of the patients was 47.5 years (age range, 15 to 76.3 years), and 56.4% were men. The most common presenting symptom was chest wall mass in 29 patients (52.7%). The median symptom duration was 12 months. Tumor size ranged from 1 to 26 cm (median size, 9.7 cm). The most common histologic type of tumor was fibrosarcoma (52.7%). Twenty-three sarcomas (41.8%) were high-grade, and 32 sarcomas (52.8%) were low-grade. Of the 55 patients, 27 (49.1%) had previously been treated elsewhere (surgical resection, 23 patients; radiation therapy and surgery, 3 patients; chemoradiation therapy, 1 patient). Previously treated patients presented either with residual disease (10 cases) or recurrence of disease (17 cases). All 55 patients underwent surgical resection, 15 patients (27.3%) were treated by neoadjuvant chemoradiation therapy, and 2 patients were treated by adjuvant radiotherapy. Wide surgical resection was performed in 45 patients (81.8%), and marginal resection was performed in 10 patients (18.2%). The median follow-up time was 51.9 months. Local recurrence of disease developed in 6 patients, and metastases developed in 10 patients. The overall survival rates at 5 and 10 years were 87.3% and 79.3%, respectively. Tumor size < 5 cm and low histologic grade were determinants of better survival at univariate analyses. Multivariate analyses disclosed only histologic grade as an independent predictor for the risk of death. Disease-free survival rates at 5 and 10 years were 75.3% and 64.2%, respectively. Tumor size < 5 cm, performance of wide surgical resection, and low histologic grade were determinants of a better disease-free survival rate. Independent prognostic factors for disease-free survival were histologic grade and type of surgical resection.
  
  
  CONCLUSIONS
  The clinical behavior of chest wall soft-tissue sarcomas is similar to that of extremity sarcomas. Thoracic wall soft-tissue sarcomas are best controlled by wide surgical resection.
authors.affiliation: Department of Thoracic Surgery, Hospsital do Cancer A.C. Camargo, Sao Paulo, Brazil. jefluizgross@yahoo.com.br
authors.forename: Jefferson Luiz
authors.initials: JL
authors.lastname: Gross
authors.forename: Riad Naim
authors.initials: RN
authors.lastname: Younes
authors.forename: Fabio José
authors.initials: FJ
authors.lastname: Haddad
authors.forename: Daniel
authors.initials: D
authors.lastname: Deheinzelin
authors.forename: Clovis Antonio Lopes
authors.initials: CA
authors.lastname: Pinto
authors.forename: Marcelo Leite Vieira
authors.initials: ML
authors.lastname: Costa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012509:Sarcoma / Q000401:mortality / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D015996:Survival Rate; D013899:Thoracic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D035441:Thoracic Wall