Mouse models for human lung cancer.
In recent years several new mouse models for lung cancer have been described. These include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). Tumorigenesis in these conditional mouse tumor models can be initiated in adult mice through Cre-recombinase-induced activation of oncogenic mutations in a subset of the cells. They present a marked improvement over mouse models that depend on carcinogen induction of tumors. These models permit us to study the consecutive steps involved in initiation and progression and allow us to address questions like the cell of origin, and the role of cancer stem cells in the maintenance of these tumors. They now need to be validated as suitable preclinical models for intervention studies in which questions with respect to therapy response and resistance can be addressed.
Meuwissen
Ralph
R
Division of Molecular Genetics and Center of Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.
Berns
Anton
A
D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000503:physiopathology; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000503:physiopathology; D004254:DNA Nucleotidyltransferases / Q000494:pharmacology; D004195:Disease Models, Animal; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects* / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006133:Growth Substances / Q000378:metabolism; D051379:Mice; D009154:Mutation / Q000235:genetics; D009362:Neoplasm Metastasis / Q000235:genetics / Q000503:physiopathology; D009857:Oncogenes / Q000235:genetics*; D013234:Stem Cells / Q000502:physiology
D006133:Growth Substances; D004254:DNA Nucleotidyltransferases