Calling for help is independently modulated by brain systems underlying goal-directed behavior and threat perception.
In primates, during times of need, calling for help is a universal experience. Calling for help recruits social support and promotes survival. However, calling for help also can attract predators, and it is adaptive to inhibit calls for help when a potential threat is perceived. Based on this, we hypothesized that individual differences in calling for help would be related to the activity of brain systems that mediate goal-directed behavior and the detection of threat. By using high-resolution positron emission tomography in rhesus monkeys undergoing social separation, we demonstrate that increased [18F]-fluoro-2-deoxy-D-glucose uptake in the right dorsolateral prefrontal cortex and decreased uptake in the amygdala independently predict individual differences in calling for help. When taken together, these two regions account for 76% of the variance in calling for help. This result suggests that the drive for affiliation and the perception of threat determine the intensity of an individual's behavior during separation. These findings in monkeys are relevant to humans and provide a conceptual neural framework to understand individual differences in how primates behave when in need of social support.
Fox
Andrew S
AS
Waisman Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin, Madison, WI 53706, USA.
Oakes
Terrence R
TR
Shelton
Steven E
SE
Converse
Alexander K
AK
Davidson
Richard J
RJ
Kalin
Ned H
NH
D000819:Animal Communication; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D010465:Perception / Q000502:physiology*; D049268:Positron-Emission Tomography