title: Efficacy of hyoscine-N-butyl bromide (Buscopan) suppositories as a cervical spasmolytic agent in labour.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of hyoscine-N-butyl bromide (Buscopan) suppositories in the active phase of labour, i.e. once the labour is established.
  
  
  METHODS
  A non-randomised controlled prospective study was carried out on 200 women in labour. In the active phase of labour, at 3 cm or more cervical dilatation, 100 women were administered Buscopan via suppository and 100 women (control) were not given any drug.
  
  
  RESULTS
  The duration of first stage of labour was 123.86 +/- 68.89 (mean(+)-standard deviation) minutes in the study group and 368.05 +/- 133.0 min in the control group. These differences were statistically significant. There were no differences in the duration of the second and third stages of labour. There was no increased incidence of operative deliveries in the study group. No adverse effects were noted on the mother or fetus.
  
  
  CONCLUSIONS
  Hyoscine-N-butyl bromide (HBB, Buscopan) suppositories were highly effective in shortening the duration of the first stage of labour.
authors.affiliation: Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Sciences, Haryana, India.
authors.forename: Daya
authors.initials: D
authors.lastname: Sirohiwal
authors.forename: Krishna
authors.initials: K
authors.lastname: Dahiya
authors.forename: Mandira
authors.initials: M
authors.lastname: De
mesh_terms: D000282:Administration, Intravaginal; D002086:Butylscopolammonium Bromide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007747:Labor Stage, First / Q000187:drug effects*; D010276:Parasympatholytics / Q000008:administration & dosage*; D011247:Pregnancy; D011446:Prospective Studies; D013488:Suppositories / Q000008:administration & dosage; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010276:Parasympatholytics; D013488:Suppositories; D002086:Butylscopolammonium Bromide