Kinetic resolution of sec-alcohols using a new class of readily assembled (S)-proline-derived 4-(pyrrolidino)-pyridine analogues.
We report the development of a new class of readily prepared chiral 4-(pyrrolidino)-pyridine catalysts capable of exploiting both van der Waals (pi) and H-bonding interactions, thus allowing remote chiral information to stereochemically control the kinetic resolution of sec-alcohols.
Dálaigh
Ciarán O
CO
Department of Chemistry, University of Dublin, Trinity College, Dublin 2, Ireland.
Hynes
Stephen J
SJ
Maher
Declan J
DJ
Connon
Stephen J
SJ
D000438:Alcohols / Q000737:chemistry; D002384:Catalysis; D006860:Hydrogen Bonding; D007700:Kinetics; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011392:Proline / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
D000438:Alcohols; D011725:Pyridines; D011759:Pyrrolidines; D011392:Proline; C023666:pyridine