title: Rose (Rosa rugosa)-flower extract increases the activities of antioxidant enzymes and their gene expression and reduces lipid peroxidation.
abstract: The effects of rose-flower extract on antioxidant enzymes were studied. The activities of catalase (CAT) and glutathione peroxidase (GPx) in 9-month-old senescence-accelerated mice (SAM mice) were lower than those in 6-month-old SAM mice. Therefore, 9-month-old SAM mice were the most appropriate targets for treatment with the rose-flower extract. The activities of CAT and GPx in SAM mice treated with rose-flower extract showed a marked increase in whole blood and liver. At the same time, the gene-expression level of CAT and GPx was upregulated in the liver, while malondialdehyde content in liver and brain decreased. Male SAM mice were more sensitive than female SAM mice. The mean and the longest lifespan of SAM mice were longer after treatment with rose-flower extract.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. biochemistry@cuhk.edu.hk
authors.forename: T B
authors.initials: TB
authors.lastname: Ng
authors.forename: W
authors.initials: W
authors.lastname: Gao
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: S M
authors.initials: SM
authors.lastname: Niu
authors.forename: L
authors.initials: L
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: L S
authors.initials: LS
authors.lastname: Shi
authors.forename: M
authors.initials: M
authors.lastname: Fu
authors.forename: F
authors.initials: F
authors.lastname: Liu
mesh_terms: D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D035264:Flowers / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D027826:Rosa / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D002374:Catalase; D013482:Superoxide Dismutase