Fatal varicella associated with selective natural killer cell deficiency.
A 2-year-old girl with recurrent severe varicella infections had a fatal outcome. Studies of cellular and humoral immunity were normal. No natural killer (NK) cells were detected, and NK activity was markedly decreased. The interleukin (IL)15/IL15R signaling pathway was intact. This case emphasizes the role of NK cells in controlling herpes viral infection.
Etzioni
Amos
A
Meyer Children's Hospital, Department of Immunology, B. Rappaport Medical School, Technion, Haifa, Israel. etzioni@rambam.health.gov.il
Eidenschenk
Celine
C
Katz
Rina
R
Beck
Rafeal
R
Casanova
Jean Laurent
JL
Pollack
Shimon
S
D002644:Chickenpox / Q000276:immunology*; D020804:Encephalitis, Varicella Zoster / Q000276:immunology*; D017809:Fatal Outcome; D005260:Female; D014645:Herpesvirus 3, Human; D006801:Humans; D007223:Infant; D007694:Killer Cells, Natural / Q000276:immunology* / Q000502:physiology; D012008:Recurrence