Site-specific phenylation of pyridine catalyzed by phosphido-bridged ruthenium dimer complexes: a prototype for C-H arylation of electron-deficient heteroarenes.
Direct and selective catalytic arylation of alpha-C-H bond in pyridine with iodobenzene was achieved in up to 70% yield. Phosphido-bridged bisruthenium complexes 6a and 6b arising from Ru3(CO)12 and PPh3 were identified as active catalysts. The formation of complexes 6a and 6b was investigated, a sequence of C-H and C-P bond cleavage, cluster fragmentation, and disproportionation was established, and the intermediate ruthenium complexes lying on this pathway were isolated and fully characterized.
Godula
Kamil
K
Department of Chemistry, Columbia University, 3000 Broadway, New York, New York 10027, USA.
Sezen
Bengü
B
Sames
Dalibor
D
D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D019281:Dimerization; D007462:Iodobenzenes / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*
D001555:Benzene Derivatives; D007462:Iodobenzenes; D009943:Organophosphorus Compounds; D010720:Phosphines; D011725:Pyridines; D012428:Ruthenium; C031905:iodobenzene