title: Toxicity to topical dimethyl sulfoxide in a pediatric patient with anthracycline extravasation.
abstract: Accidental extravasation of vesicant chemotherapy may cause important tissue injuries. Nowadays, the majority of authors propose topical dimethyl sulfoxide (DMSO), with or without local cooling, as the treatment of choise efor anthracyclines extravasation. No significant toxicity has been reported when DMSO is used as topical treatment. This report describes a case of local toxicity consisting of severe pain after its use in a pediatric patient. An illustration shows the extravasation area.
authors.affiliation: Division of Hematology Oncology, Pediatric Department, University Hospital Virgen de la Arrixaca, Murcia, Spain.
authors.forename: M E
authors.initials: ME
authors.lastname: Llinares
authors.forename: M
authors.initials: M
authors.lastname: Bermúdez
authors.forename: J L
authors.initials: JL
authors.lastname: Fuster
authors.forename: M S
authors.initials: MS
authors.lastname: Diaz
authors.forename: C M
authors.initials: CM
authors.lastname: Gonzalez
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D002675:Child, Preschool; D004121:Dimethyl Sulfoxide / Q000009:adverse effects* / Q000627:therapeutic use; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy
chemical_list: D000903:Antibiotics, Antineoplastic; D004121:Dimethyl Sulfoxide