Nano-scaled hydroxyapatite/polymer composite III. Coating of sintered hydroxyapatite particles on poly(4-methacryloyloxyethyl trimellitate anhydride)-grafted silk fibroin fibers.
A novel composite coupling between nano-scaled hydroxyapatite (HAp) particles and poly[4-methacryloyloxyethyl trimellitate anhydride (4-META)]-grafted silk fibroin (SF) through ionic interaction was synthesized. The weight gain of poly(4-META) by graft-polymerization increased with increasing the reaction time, eventually reaching a plateau value of about 20 wt%. The HAp nano-particles were adsorbed equally and dispersively on the treated SF fiber surface. The HAp content in the composite was 4.554 wt% +/- 0.098 (n = 4), confirmed by thermogravimetry (TG). This synthetic system requires no heat to connect HAp to SF and is useful when applying to non-heat-resistant polymers. The L-929 cell-adhesion test shows that the HAp/SF composite improves bioactivity compared to the original SF.
Korematsu
Arata
A
Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
Furuzono
Tsutomu
T
Yasuda
Shoji
S
Tanaka
Junzo
J
Kishida
Akio
A
D020099:Coated Materials, Biocompatible / Q000032:analysis / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D017886:Durapatite / Q000737:chemistry*; D005349:Fibroins / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure*; D006358:Hot Temperature; D008422:Materials Testing; D008689:Methacrylates / Q000032:analysis / Q000737:chemistry*; D049329:Nanostructures / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D013499:Surface Properties
D020099:Coated Materials, Biocompatible; D008689:Methacrylates; C482288:fibroin, silkworm; C034139:4-methacryloxyethyltrimellitic acid anhydride; D005349:Fibroins; D017886:Durapatite