title: In vitro antistaphylococcal activity of dalbavancin, a novel glycopeptide.
abstract: OBJECTIVE
  Dalbavancin is a novel, semi-synthetic glycopeptide antibiotic. The aim of this study was to further explore its activity against staphylococci.
  
  
  METHODS
  The bactericidal activity of dalbavancin was studied using MBC and time-kill methods. The potential for resistance to dalbavancin was examined using single-step and serial-passage experiments.
  
  
  RESULTS
  Dalbavancin was bactericidal against methicillin-susceptible and -resistant Staphylococcus aureus, in both the presence and absence of human serum. No resistance was seen with any isolate tested. After serial passage, bacterial populations were more homogeneous in their susceptibility to dalbavancin than to vancomycin or teicoplanin.
  
  
  CONCLUSIONS
  Dalbavancin is bactericidal for staphylococci. Resistance to this semi-synthetic glycopeptide is not readily developed in vitro.
authors.affiliation: Vicuron Pharmaceuticals, Fremont, CA, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Lopez
authors.forename: Corinne
authors.initials: C
authors.lastname: Hackbarth
authors.forename: Gabriella
authors.initials: G
authors.lastname: Romanò
authors.forename: Joaquim
authors.initials: J
authors.lastname: Trias
authors.forename: Daniela
authors.initials: D
authors.lastname: Jabes
authors.forename: Beth P
authors.initials: BP
authors.lastname: Goldstein
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006020:Glycopeptides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects; D017334:Teicoplanin / Q000494:pharmacology / Q000031:analogs & derivatives; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D017334:Teicoplanin; D014640:Vancomycin; C469289:dalbavancin