Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats.
We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing. However, chronic, 14-day forced-swim stress testing blocked the immobility-decreasing effect induced by a single administration of imipramine. When imipramine was administered for 14 days concurrently with forced-swim stress testing, immobility was shortened significantly. From the viewpoint of imipramine's effect, these findings suggest that chronic forced-swim stress testing in rats may be an effective animal model for depression.
Kitamura
Yoshihisa
Y
Department of Hospital Pharmacy, Okayama University Medical School, Okayama 700 8558, Japan. ykita@cc.okayama-u.ac.jp
Araki
Hiroaki
H
Nagatani
Tadashi
T
Takao
Katsuyuki
K
Shibata
Kazuhiko
K
Gomita
Yutaka
Y
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy; D007099:Imipramine / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological; D013550:Swimming
D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine