Chondrosarcomas of the base of the skull in Ollier's disease or Maffucci's syndrome--three case reports and review of the literature.
Ollier's disease is a rare disease characterized by constitutional bone dysplasia with multiple enchondromas. The combination of haemangioma and chondromatoses is known as Maffucci's syndrome. Malignant degeneration of bone dysplasia into chondrosarcoma is a well-known complication, but a lesion of the base of the skull is exceptional. It is a slowly growing low-grade malignant tumour. Three new cases of chondrosarcoma of the base of the skull occurring in one patient with Marfucci's syndrome and two patients with Ollier's disease are reported and these cases are discussed in the light of the literature. A multidisciplinary approach, comprising surgery and radiotherapy, achieved good results.
Noël
Georges
G
Centre de Protonthérapie d'Orsay--Institut Curie, Orsay cedex Paris, France. noel@ipno.in2p3.fr
Feuvret
Loïc
L
Calugaru
Valentin
V
Hadadi
Khalid
K
Baillet
François
F
Mazeron
Jean-Jacques
JJ
Habrand
Jean-Louis
JL
D000328:Adult; D002648:Child; D002813:Chondrosarcoma / Q000175:diagnosis* / Q000532:radiotherapy; D004687:Enchondromatosis / Q000175:diagnosis* / Q000532:radiotherapy; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D011882:Radiotherapy, High-Energy; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000175:diagnosis*; D019292:Skull Base Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D013577:Syndrome; D014057:Tomography, X-Ray Computed