[Vascular endothelial growth factor expression in focal cerebral ischemia/reperfusion in injury in rats].
OBJECTIVE
To study the vascular endothelial growth factor (VEGF) expression and its role in focal cerebral ischemia/reperfusion injury.


METHODS
VEGF protein and mRNA expressions at the site of focal ischemia/reperfusion of rat cerebrum were assessed with immunohistochemistry and hybridization techniques.


RESULTS
In normal cerebral tissue there was lower expression of VEGF. It was found to be expressed in the penumbra area after ischemia. With the prolongation of ischemia and ischemia/reperfusion, enhanced expression of VEGF tended to decline to normal level, while it enhanced in the penumbra area.


CONCLUSIONS
Enhanced VEGF expression might play a protective role in focal ischemia/reperfusion injury to the cerebrum.
Xing
Ying
Y
Department of Neurology, China - Japan Union Hospital, Jilin University, Changchun, China.
Xu
Zhong-xin
ZX
Mang
Jing
J
Qian
Jia-li
JL
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D004195:Disease Models, Animal; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat