title: [Effect of compound shenhua tablet on macrophage migration inhibition factor in renal tissue of 5/6 nephrectomized rats].
abstract: OBJECTIVE
  To observe the effect of compound shenhua tablet (CST) on the residual kidney expressed macrophage migration inhibition factor (MIF) in rats.
  
  
  METHODS
  CST was used to treat 5/6 nephrectomized rats for 12 weeks and the conditions of blood pressure, urinary protein, blood biochemical indices (creatinine, blood urea nitrogen), kidney pathologic change and MIF expression were observed.
  
  
  RESULTS
  CST could significantly lower the serum levels of creatinine (P < 0.05), and 24 hrs urinary protein (P < 0.01), reduce the MIF expression and macrophage infiltration in renal glomerulus and tubular mesenchym, and lower the degree of renal glomerular sclerosis and interstitial fibrosis.
  
  
  CONCLUSIONS
  The inhibition on the highly expressed MIF may be an important mechanism of the drug in restraining chronic inflammation in residual kidney, delaying the sclerosis and fibrosis progression and protecting renal function.
authors.affiliation: Department of Nephrology, General Hospital of PLA, Beijing 100085.
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Li
authors.forename: Xiang-mei
authors.initials: XM
authors.lastname: Chen
authors.forename: Yue
authors.initials: Y
authors.lastname: Gu
authors.forename: Ri-bao
authors.initials: RB
authors.lastname: Wei
authors.forename: Jing
authors.initials: J
authors.lastname: Du
authors.forename: Suo-zhu
authors.initials: SZ
authors.lastname: Shi
authors.forename: Zhong
authors.initials: Z
authors.lastname: Yi
mesh_terms: D000419:Albuminuria / Q000097:blood; D000818:Animals; D003404:Creatinine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005355:Fibrosis / Q000473:pathology; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets
chemical_list: D004365:Drugs, Chinese Herbal; D008263:Macrophage Migration-Inhibitory Factors; D013607:Tablets; C000592784:shenhua; D003404:Creatinine