[Application of mesenchymal stem cell in immunotherapy--review].
There has been an increasing interest in recent years on mesenchymal stem cell (MSC). It is well known that MSCs are capable of self-renewal and differentiating into many cell lineages. MSC can be expended to a large quantity that is required for clinical transplantation. Recent studies show that MSC have potential application in immune diseases due to their unique immunologic characteristics, such as low immunogenicity and immunoregulatory function. But their immunoregulatory mechanism is not yet clear. This review discusses the advances in researches on the mechanism of MSCs' immunoregulatory function and potential clinical application in immune disease and organ transplantation.
Liao
Lian-Ming
LM
Institnte of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100730, China.
Han
Qin
Q
Zhao
Chun-Hua
CH
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007167:Immunotherapy; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology