[Case of drug-induced pneumonia possibly due to mefloquine (antimalarial drug)].
A 59-year-old man took mefloquine (antimalarial drug), total dose of 1,000 mg, to prevent malaria before and during traveling to South Africa. Three weeks after the first administration, he was admitted complaining of fever and dyspnea. Chest HRCT showed ground-glass opacities and consolidation in both lung fields. Withdrawal of mefloquine and treatment with corticosteroid resulted in improvement of the clinical findings. From the clinical course, we considered this case to be mefloquine-induced pneumonia. Mefloquine may have caused pulmonary toxicity.
Inoue
Tetsuro
T
Department of Respiratory Medicine, Tenri Hospital.
Tanaka
Eisaku
E
Sakuramoto
Minoru
M
Minakuchi
Masayoshi
M
Maeda
Yuji
Y
Maniwa
Ko
K
Terada
Kunihiko
K
Goto
Shunsuke
S
Takeda
Tomoshi
T
Noma
Satoshi
S
Taguchi
Yoshio
Y
D000208:Acute Disease; D000962:Antimalarials / Q000009:adverse effects*; D006801:Humans; D008288:Malaria / Q000517:prevention & control; D008297:Male; D015767:Mefloquine / Q000009:adverse effects*; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage; D020551:Pulse Therapy, Drug; D012131:Respiratory Insufficiency / Q000139:chemically induced; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000962:Antimalarials; D011239:Prednisolone; D015767:Mefloquine; D008775:Methylprednisolone