Influence of serotonin on the analgesic effect of granisetron on temporomandibular joint arthritis.
The influence of circulating serotonin (5-HT) on the effects of intra-articular administration of granisetron on temporomandibular joint (TMJ) pain was investigated in 11 patients with chronic polyarthritides. An analgesic effect superior to placebo has been shown previously. The change in TMJ movement pain intensity was negatively correlated to circulating 5-HT; that is, the higher the 5-HT before injection, the greater the reduction of pain intensity. The resting pain intensity reduction was not related to 5-HT. In conclusion, this study indicates a stronger short-term analgesic effect on TMJ movement pain by intra-articular administration of the 5-HT3 receptor antagonist granisetron in patients with high levels of circulating 5-HT.
Voog
Ulle
U
Department of Clinical Oral Physiology, Institute of Odontology, Karolinska Institutet, Box 4064, 141 04 Huddinge, Sweden.
Alstergren
Per
P
Leibur
Edvitar
E
Kallikorm
Riina
R
Kopp
Sigvard
S
D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D001168:Arthritis / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D017829:Granisetron / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy; D012701:Serotonin / Q000097:blood*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D013705:Temporomandibular Joint Disorders / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D017829:Granisetron; D012701:Serotonin; D012702:Serotonin Antagonists