title: Levels of malondialdehyde and superoxide dismutase in subclinical hyperthyroidism.
abstract: We aimed to determine whether patients with subclinical hyperthyroidism (SH) are subject to oxidative stress. Twenty-two women and 8 men having endogenous subclinical hyperthyroidism for a duration of at least 6 months, and 21 women and 9 men healthy controls were included in this study. We measured the level of plasma malondialdehyde, as one of the lipid peroxidation markers, and the activity of erythrocyte superoxide dismutase, which is an antioxidant enzyme. The activity of erythrocyte superoxide dismutase and plasma malondialdehyde levels were found to be significantly higher in subjects with subclinical hyperthyroidism than the control group (P < .01). The results of this study suggest that oxidative stress and antioxidative response could be increased in patients having subclinical hyperthyroidism.
authors.affiliation: Department of Internal Medicine, Medical Faculty, Sutcu Imam University, Kahramanmaras-46060, Turkey. alicetinkaya@ksu.edu.tr
authors.forename: Ali
authors.initials: A
authors.lastname: Cetinkaya
authors.forename: Ergul Belge
authors.initials: EB
authors.lastname: Kurutas
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Buyukbese
authors.forename: Bulent
authors.initials: B
authors.lastname: Kantarceken
authors.forename: Ertan
authors.initials: E
authors.lastname: Bulbuloglu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D012016:Reference Values; D013482:Superoxide Dismutase / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D008315:Malondialdehyde; D013482:Superoxide Dismutase