title: Wood dust exposure and the association with lung cancer risk.
abstract: BACKGROUND
  Wood dust was designated as a human carcinogen based on increased sinus and nasal cancer rates among exposed workers. However, data on an association with lung cancer have been inconclusive.
  
  
  METHODS
  Self-reported wood dust exposure was compared between 1,368 lung cancer patients and 1,192 cancer-free adults, in a lung cancer case-control study. Epidemiological information was collected through a detailed personal interview.
  
  
  RESULTS
  Using several definitions of wood dust exposure we consistently observed statistically significant elevated adjusted risk estimates; for example, the adjusted odds ratio (OR) for combined wood dust related occupations and industries was 3.15 (95% confidence intervals (CI) 1.45-6.86) and for an overall summary exposure measure it was 1.60 (95% CI 1.19-2.14). The association was maintained when stratified by histopathological type. Among those exposed to cigarette smoke and wood dust, 21% of the cases were attributable to biologic interaction.
  
  
  CONCLUSIONS
  Wood dust exposure is a potential risk factor for lung cancer.
authors.affiliation: Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77225-0186, USA.
authors.forename: Carlos H
authors.initials: CH
authors.lastname: Barcenas
authors.forename: George L
authors.initials: GL
authors.lastname: Delclos
authors.forename: Randa
authors.initials: R
authors.lastname: El-Zein
authors.forename: Guillermo
authors.initials: G
authors.lastname: Tortolero-Luna
authors.forename: Lawrence W
authors.initials: LW
authors.lastname: Whitehead
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Spitz
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000032:analysis; D016022:Case-Control Studies; D004391:Dust; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D016015:Logistic Models; D008175:Lung Neoplasms / Q000453:epidemiology*; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014481:United States / Q000453:epidemiology; D014934:Wood
chemical_list: D000395:Air Pollutants, Occupational; D004391:Dust