title: Hypertension and cognitive performance in African Americans with Alzheimer disease.
abstract: The authors examined the relationship between hypertension and cognitive performance in 34 African-American patients with probable Alzheimer disease. Multiple regression analyses indicated that hypertension was associated with poorer overall performance on the Mattis Dementia Rating Scale, particularly the Initiation/Perseveration and Conceptualization subscales, after controlling for gender, age, and education. The findings suggest that African-American patients with hypertension exhibit greater cognitive impairment, possibly reflecting executive dysfunction.
authors.affiliation: Department of Neurology, Emory University School of Medicine, 1841 Clifton Road, N.E., Atlanta, GA 30329, USA. fgoldst@emory.edu
authors.forename: F C
authors.initials: FC
authors.lastname: Goldstein
authors.forename: A V
authors.initials: AV
authors.lastname: Ashley
authors.forename: L J
authors.initials: LJ
authors.lastname: Freedman
authors.forename: L
authors.initials: L
authors.lastname: Penix
authors.forename: J J
authors.initials: JJ
authors.lastname: Lah
authors.forename: J
authors.initials: J
authors.lastname: Hanfelt
authors.forename: A I
authors.initials: AI
authors.lastname: Levey
mesh_terms: D001741:Black or African American / Q000208:ethnology* / Q000235:genetics; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000208:ethnology / Q000523:psychology; D015984:Causality; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D003072:Cognition Disorders / Q000150:complications* / Q000208:ethnology / Q000523:psychology; D003863:Depression / Q000150:complications; D004522:Educational Status; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000208:ethnology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012044:Regression Analysis; D012737:Sex Factors
chemical_list: D002800:Cholinesterase Inhibitors