title: Parkinson's disease: from causes to mechanisms.
abstract: Parkinson's disease (PD) is a common age-related, progressive neurodegenerative disease of unknown etiology. Environmental factors have long been suspected to participate in the pathogenesis of PD due to the existence of neurotoxins that preferentially damage the dopaminergic nigrostriatal pathway. In the past few years, novel insights into the degenerative process have been provided by the discovery of genes responsible for rare monogenic parkinsonian syndromes. Compelling evidence is accumulating, suggesting that the products of several of these genes can interact with environmental toxins and intervene in molecular pathways controlling the functional integrity of mitochondria.
authors.affiliation: INSERM U 289, hôpital de la Pitié-Salpêtrière, 47, bd de l'Hôpital, 75013 Paris, France.
authors.forename: Olga
authors.initials: O
authors.lastname: Corti
authors.forename: Cornelia
authors.initials: C
authors.lastname: Hampe
authors.forename: Frédéric
authors.initials: F
authors.lastname: Darios
authors.forename: Pablo
authors.initials: P
authors.lastname: Ibanez
authors.forename: Merle
authors.initials: M
authors.lastname: Ruberg
authors.forename: Alexis
authors.initials: A
authors.lastname: Brice
mesh_terms: D003342:Corpus Striatum / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000473:pathology / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics; D010300:Parkinson Disease / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D013378:Substantia Nigra / Q000503:physiopathology; D051843:Synucleins; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
chemical_list: D009419:Nerve Tissue Proteins; D051843:Synucleins; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D004298:Dopamine