[Preparation of a syrup with Bakis roots (Tinospora bakis) and evaluation of its choleretic activity in rats].
The aim of this work was to prepare a pharmaceutical using the aqueous extract of bakis roots and to check if the choleretic activity of this latter was maintained in cholestatic rats. So, a sirup was prepared and tested. The obtained results had shown that the aqueous extract maintained its choleretic activity. Indeed, when it was used at a dose of about 7.5 mg/100 g of weight, the sirup induced a significant increase of bilary secretion in healthy rats and cholestatic rats, confirming the results observed with the aqueous extract. Therefore, futher investigations in order to improve the quality of the sirup can be considered before performing clinical trials.
Thioune
O
O
Laboratoire de Pharmacie Galénique et Législation, Faculté de Médecine, de Pharmacie et d'Odonto Stomatoiogie, UCAD, Senegal.
Sene
C T
CT
Ngom
S
S
Diop
A B
AB
Bassene
E
E
Faye
B
B
Lo
I
I
D000818:Animals; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D002779:Cholestasis / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D031610:Tinospora
D002756:Cholagogues and Choleretics; D010936:Plant Extracts