title: [The antimicrobial effects of chitosans on oral pathogenic microbes in vitro].
abstract: OBJECTIVE
  To study the antimicrobial activities of chitosans of different molecular weights and concentrations on oral pathogenic microbes under pH 6.5 in vitro.
  
  
  METHODS
  The inhibition effects of chitosans of different molecular weights and different concentrations (2.0%, 1.5%, 1.0%, 0.5%) on Staphylococcus aureus, Candida albicans, Helicobacter pylori, Streptococcus mutans and Porphyromonas gingivalis in culture were investigated, and the differences of their antimicrobial activities under high temperature and after filtering were compared. One way analysis of variance, randomized block design analysis of variance and t test were used for statistical analysis.
  
  
  RESULTS
  Chitosans of different molecular weights all showed bacteriostatic effects on Staphylococcus aureus, Candida albicans, Helicobacter pylori, Streptococcus mutans and Porphyromonas gingivalis. Low molecular weight chitosans showed the strongest effects, but the high molecular weight ones had strong effects on Streptococcus mutans (P<0.05,0.01). The bacteriostatic effects of chitosans were not affected by high temperatures (P>0.05).
  
  
  CONCLUSIONS
  Chitosans have inhibitory effects on oral pathogenic microbes under pH 6.5.
authors.affiliation: Department of Stomotology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, Shandong Province, China. dengjing6666@yahoo.com.cn
authors.forename: Jing
authors.initials: J
authors.lastname: Deng
authors.forename: Da-Yong
authors.initials: DY
authors.lastname: Fu
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Song
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Yuan
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D048271:Chitosan / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects; D008970:Molecular Weight; D016966:Porphyromonas gingivalis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D048271:Chitosan