[Differential changes in IgG1 and IgG3 against a major antigen of blood stage Plasmodium falciparum (MSP1(19)) as a function of the parasite transmission period: study among immune Senegalese adults].
This study examined the evolution of P. falciparum specific IgG1 and IgG3 antibodies "before" and "after" the highest transmission period in clinically immune Senegalese adults settle in Dielmo, a holoendemic area for P. falciparum transmission. Plasma was tested for antibodies to an antigen (Q-KNG- MSP1(19)) known to react with IgG1 and/or IgG3 in the majority of these individuals. There was a decrease in titers in individuals with low, but not high titer IgG1 whereas specific IgG3 remained unchanged following the highest transmission period. These results raise the question of the differential role of anti-MSP1(19)g-IgG1 antibody fractions in the maintenance of immunity to P. falciparum.
Diallo
T O
TO
Institut Pasteur de Dakar BP 220 - Dakar (Sénégal).
Tall
A
A
Lochouarn
L
L
Diouf
A
A
Perraut
R
R
Garraud
O
O
D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D017780:Malaria Vaccines; D016778:Malaria, Falciparum / Q000276:immunology / Q000635:transmission; D008297:Male; D020066:Merozoite Surface Protein 1 / Q000276:immunology*; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000276:immunology*; D012675:Senegal
D007074:Immunoglobulin G; D017780:Malaria Vaccines; D020066:Merozoite Surface Protein 1