CXCL11 is involved in leucocyte recruitment to the central nervous system in neuroborreliosis.
We investigated the role of the CXCR3 chemokine CXCL11 (I-TAC) for leukocyte recruitment to the CSF in neuroborreliosis (NB). CXCL11 levels in the CSF of 17 patients with acute NB were elevated compared with 20 non-inflammatory controls (100.1 vs. 54.1 pg/ml, p = 0.002). Using a modified Boyden chamber chemotaxis-assay, the CSF of patients with acute NB was more chemotactic than the control CSF-samples (p = 0.001). A strong correlation (p < 0.001) between CXCL11 levels, chemotactic activity and CSF-white cell count was detected. Though the chemotactic activity of CSF from NB patients was only partially reduced by a human recombinant CXCL11 antibody, these findings suggest that, among other chemotactic factors, CXCL11 may play a role in the chemotaxis of mononuclear cells in NB.
Rupprecht
Tobias A
TA
Dept. of Neurology, Klinikum Grosshadern Ludwig-Maximilians University, Marchioninistr. 15, 81377 Munich, Germany.
Koedel
Uwe
U
Muhlberger
Beatrice
B
Wilske
Bettina
B
Fontana
Adriano
A
Pfister
Hans-Walter
HW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002490:Central Nervous System / Q000276:immunology / Q000378:metabolism*; D018932:Chemokine CCL2 / Q000134:cerebrospinal fluid; D054371:Chemokine CXCL11; D019743:Chemokines, CXC / Q000134:cerebrospinal fluid* / Q000378:metabolism / Q000502:physiology; D002633:Chemotaxis / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000276:immunology / Q000473:pathology*; D020852:Lyme Neuroborreliosis / Q000134:cerebrospinal fluid / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D018709:Statistics, Nonparametric
C515202:CXCL11 protein, human; D018932:Chemokine CCL2; D054371:Chemokine CXCL11; D019743:Chemokines, CXC