title: Substituted aziridines by lithiation-electrophile trapping of terminal aziridines.
abstract: [reaction: see text] Regio- and stereoselective deprotonation of N-Bus (Bus = tert-butylsulfonyl)-protected terminal aziridines with lithium 2,2,6,6-tetramethylpiperidide generates a nonstabilized (H-substituted) aziridinyl anion that undergoes in situ or external electrophile trapping under experimentally straightforward conditions to give trans-disubstituted aziridines in good to excellent yields.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: David M
authors.initials: DM
authors.lastname: Hodgson
authors.forename: Philip G
authors.initials: PG
authors.lastname: Humphreys
authors.forename: John G
authors.initials: JG
authors.lastname: Ward