[Regulation of transcription in different HIV-1 subtypes].
Transcriptional activation of HIV-1 gene expression is controlled in part by the interaction of viral and cellular transcription factors with the HIV-1 long terminal repeat (LTR) sequences. LTR variability among different HIV-1 subtypes could affect LTR binding of either cellular or viral elements, influencing the transcription level. This effect, in turn, may have consequences on the biology of the different HIV-1 clades and on disease progression. In some circumstances, a relationship between replication capacity in vitro and changes in binding sequences for transcription factors located at the LTR has been proven.
Ramírez de Arellano
Eva
E
Laboratorio de Biología Molecular, Servicio de Enfermedades Infecciosas, Hospital Carlos III, Madrid, Spain.
Soriano
Vicente
V
Holguín
Africa
A
D002478:Cells, Cultured / Q000821:virology; D015967:Gene Expression Regulation, Viral; D015696:Gene Products, tat / Q000502:physiology; D014644:Genetic Variation; D016325:HIV Long Terminal Repeat / Q000235:genetics / Q000502:physiology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D025941:Protein Interaction Mapping; D011988:Receptors, Thyroid Hormone / Q000378:metabolism; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000821:virology; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D011988:Receptors, Thyroid Hormone; D014157:Transcription Factors; D054322:tat Gene Products, Human Immunodeficiency Virus