Effect of triiodothyronine on gene transcription during cardiopulmonary bypass in infants with ventricular septal defect.
We tested the hypothesis that triiodothyronine (T3) supplementation alters gene transcription in the left ventricular myocardium of infants undergoing cardiopulmonary bypass for ventricular septal defect repair. To our knowledge, a novel heteronuclear assay demonstrated for the first time in human heart that rapid change in T3 levels altered the adenine nucleotide translocase-1 transcription rate during cardiopulmonary bypass.
Danzi
Sara
S
Division of Endocrinology, Department of Medicine, North Shore University Hospital/New York University School of Medicine, Manhasset, New York, USA.
Klein
Irwin
I
Portman
Michael A
MA
D033741:Adenine Nucleotide Translocator 1 / Q000235:genetics; D001707:Biopsy, Needle; D002315:Cardiopulmonary Bypass; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000235:genetics / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D009206:Myocardium / Q000473:pathology*; D016133:Polymerase Chain Reaction; D012332:RNA, Heterogeneous Nuclear / Q000235:genetics; D019831:Sodium-Calcium Exchanger / Q000235:genetics; D013771:Tetralogy of Fallot; D014158:Transcription, Genetic / Q000187:drug effects / Q000235:genetics*; D014284:Triiodothyronine / Q000008:administration & dosage / Q000502:physiology*; D024723:Ventricular Myosins / Q000235:genetics
D033741:Adenine Nucleotide Translocator 1; D012332:RNA, Heterogeneous Nuclear; D019831:Sodium-Calcium Exchanger; D014284:Triiodothyronine; D024723:Ventricular Myosins