Syndecans: new kids on the signaling block.
Cell-associated proteoglycans provide highly complex and sophisticated systems to control interactions of extracellular cell matrix components and soluble ligands with the cell surface. Syndecans, a conserved family of heparan- and chondroitin-sulfate carrying transmembrane proteins, are emerging as central players in these interactions. Recent studies have demonstrated the essential role of syndecans in modulating cellular signaling in embryonic development, tumorigenesis, and angiogenesis. In this review, we focus on new advances in our understanding of syndecan-mediated cell signaling.
Tkachenko
Eugene
E
Angiogenesis Research Center, Section of Cardiology, and Department of Medicine, Dartmouth Medical School, Lebanon, NH, USA.
Rhodes
John M
JM
Simons
Michael
M
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D002809:Chondroitin Sulfates / Q000737:chemistry / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D005786:Gene Expression Regulation; D006133:Growth Substances / Q000737:chemistry / Q000502:physiology; D006497:Heparan Sulfate / Q000737:chemistry / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000502:physiology*; D051379:Mice; D009024:Morphogenesis / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology; D011485:Protein Binding; D011487:Protein Conformation; D011493:Protein Kinase C / Q000502:physiology; D051571:Protein Kinase C-alpha; D017434:Protein Structure, Tertiary; D011509:Proteoglycans / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013329:Structure-Activity Relationship
D002809:Chondroitin Sulfates; D006133:Growth Substances; D006497:Heparan Sulfate; D008562:Membrane Glycoproteins; D011493:Protein Kinase C; D051571:Protein Kinase C-alpha; D011509:Proteoglycans; C496628:PRKCA protein, human; C496630:Prkca protein, mouse