Neurodevelopmental toxicology.
The fields of neurotoxicology and developmental toxicology are exploding in research and interest. Much of the data currently known are from epidemiologic human studies or studies of animal models. Each of these modes is difficult to translate to individual clinical encounters. It is often difficult to state with certainty which of the numerous chemical or physical agents in our environment are neurotoxic. Basic scientists will help with advances in molecular biology and toxicology. Improved clinical understanding of these issues may help patients to understand the medical issues; allay feelings of anxiety, guilt, or fear; and avoid unnecessary testing. For exposures that manifest as threshold phenomena, such as lead, the risk to society is even greater than to an individual. Individual risk may be less of a concern than the population's risk because small elevations in the average BLL can cause profound shifts in the normative curve of intelligence, increasing the burden on our institutions and bankrupting the brain trust. Good scholarship and interpersonal judgement are vital when counseling patients on the potential consequences of chemical exposures and are no less important when making policy. The challenge for the clinician reading the research is to remain aware of the limitations and biases of our science.
Schmid
Carrie
C
Department of Pediatrics and Neurology, Wilford Hall USAF Medical Center, San Antonio Military Pediatrics Consortium, Lackland Air Force Base, 2200 Bergquist Drive, TX 78236, USA.
Rotenberg
Joshua S
JS
D000328:Adult; D001921:Brain / Q000187:drug effects*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000139:chemically induced*; D006801:Humans; D009498:Neurotoxins / Q000009:adverse effects*; D014116:Toxicology
D009498:Neurotoxins