title: [Ca2+ -induced cell injury of cardiomyocyte].
abstract: Pathogenesis of ischemia/reperfusion injury involves Ca(2+) -induced cell injury. Elevated intracellular Ca(2+) concentration at the reperfusion activates the Ca(2+) dependent protease, calpain and increases the generation of reactive oxygen species (ROS) in mitochondria, which cause cell injury in ischemia/reperfusion.
authors.affiliation: Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Otsu
authors.forename: M
authors.initials: M
authors.lastname: Hori