Reduced replication: a call to ARMS.
In this issue of Cell, Lemoine et al. monitor chromosome instability in yeast cells with reduced levels of an essential replicative DNA polymerase. The authors identify a hotspot for chromosome aberrations reminiscent of fragile sites in human cells. This hotspot is composed of inverted Ty elements, which lead to a double-strand break under conditions of limited replication.
Resnick
Michael A
MA
Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. resnick@niehs.nih.gov
D000818:Animals; D043171:Chromosomal Instability / Q000235:genetics*; D002869:Chromosome Aberrations; D004247:DNA / Q000378:metabolism; D004260:DNA Repair / Q000235:genetics; D004261:DNA Replication / Q000235:genetics*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D006801:Humans; D018626:Retroelements / Q000235:genetics; D015003:Yeasts / Q000235:genetics*
D018626:Retroelements; D004247:DNA; D004259:DNA-Directed DNA Polymerase