title: Dendritic-cell-based therapeutic vaccination against cancer.
abstract: Early clinical trials, in which over 1000 cancer patients received dendritic cell (DC) vaccines, tested different vaccine preparations, but they did not always induce sufficient acquired immunity or meet the expected level of tumor regressions. Current studies aim to improve the DC vaccine approach and capture the potential of these cells in order to gain access to lymphoid tissues and induce strong cell-mediated immunity. DC clinical trials are moving towards a more professional environment, in accordance with the latest quality standards. This explains the current need for innovative well designed trials with defined endpoints that induce robust anti-tumor immunity.
authors.affiliation: Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland. nestle@derm.unizh.ch
authors.forename: Frank O
authors.initials: FO
authors.lastname: Nestle
authors.forename: Arpad
authors.initials: A
authors.lastname: Farkas
authors.forename: Curdin
authors.initials: C
authors.lastname: Conrad
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007272:Injections, Intralymphatic; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D000941:Antigens; D019496:Cancer Vaccines