title: [Clinical usefulness serum int-P I NP levels as a bone formation marker in hemodialysis patients].
abstract: Since intact collagen I amino-terminal propeptide (P I NP) is known to be cleared from blood via liver, its level in blood is hypothesized to be independent of renal function. Serum P I NP, in contrast to serum bone alkaline phosphatase (BAP) and intact osteocalcin (OC), did not show any significant change between before and after a hemodialysis session. Serum P I NP correlated significantly in a positive manner with the other bone formation markers, bone-specific alkaline phosphatase and osteocalcin and also with intact parathyroid hormone in the patients on hemodialysis. In summary, serum P I NP may be very useful for prediction of radius bone loss as well as other serum bone formation markers and evaluating the osteoblastic function in hemodialyzed patients.
authors.affiliation: Nozaki Clinic.
authors.forename: Genichi
authors.initials: G
authors.lastname: Shimizu
authors.forename: Shinji
authors.initials: S
authors.lastname: Mitani
authors.forename: Akiko
authors.initials: A
authors.lastname: Kawakami
authors.forename: Kanji
authors.initials: K
authors.lastname: Nozaki
authors.forename: Misako
authors.initials: M
authors.lastname: Ueda
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Nakatska
authors.forename: Masaaki
authors.initials: M
authors.lastname: Inaba
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nishizawa