title: Frequencies of the breakpoint cluster region types of the BCR/ABL fusion gene in Mexican Mestizo patients with chronic myelogenous leukemia.
abstract: There is little information about the breakpoint cluster regions of the BCR/ABL fusion gene in Mexican Mestizos with Philadelphia chromosome positive chronic myelogenous leukemia; in a small study a different distribution of these as compared with Caucasians was recently described. We have now prospectively analyzed the breakpoint cluster regions of the BCR/ABL fusion gene in a group of 238 Mexican Mestizos patients with Philadelphia chromosome positive chronic myelogenous leukemia and found a prevalence of 54.2% for the b3/a2 subtype, 43.2% for the b2a2 and 2.5% for the b3a2/b2a2. These data are not different from those previously described in other populations and are consonant with the prevalence of chronic myelogenous leukemia in Mexico, which is not different from that described in other populations.
authors.affiliation: Centro de Hematología y Medicina Interna de Puebla, Mexico. gruiz1@clinicaruiz.com
authors.forename: Guillermo J
authors.initials: GJ
authors.lastname: Ruiz-Argüelles
authors.forename: Javier
authors.initials: J
authors.lastname: Garcés-Eisele
authors.forename: Virginia
authors.initials: V
authors.lastname: Reyes-Núñez
authors.forename: Guillermo J
authors.initials: GJ
authors.lastname: Ruiz-Delgado
mesh_terms: D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D008800:Mexico; D011446:Prospective Studies; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051562:Proto-Oncogene Proteins c-bcr
chemical_list: D011518:Proto-Oncogene Proteins; C406060:abl-bcr fusion protein, human; D011505:Protein-Tyrosine Kinases; D016044:Fusion Proteins, bcr-abl; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr