Increased frequency of sister chromatid exchanges in peripheral lymphocytes of alcoholics and cigarette smokers.
Sister chromatid exchange (SCE) is a sensitive indicator of genotoxicity. In this study we investigated the effects of alcohol consumption and cigarette smoking on the frequency of SCE in cultures of peripheral lymphocytes. The rate was higher in alcoholics who smoked (10.89+/-2.46) and in smokers (positive controls) (7.64+/-1.01) than in healthy non-smokers (negative controls) (6.96+/-2.18). Statistical analysis suggested that the increases were related to alcohol consumption and cigarette smoking (p<0.05).
Karaoğuz
Meral Yirmibeş
MY
Department of Medical Genetics, Gazi University School of Medicine, Besevler, 06500 Ankara, Turkey. karaoguz@gazi.edu.tr
Coşar
Behçet
B
Arikan
Zehra
Z
Başaran
Feride
F
Menevşe
Adnan
A
Menevşe
Sevda
S
D000328:Adult; D000437:Alcoholism / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000235:genetics*