title: Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors.
abstract: BACKGROUND
  Patients with basal cell carcinoma (BCC) frequently develop further tumors during follow-up.
  
  
  OBJECTIVE
  We sought to elucidate the relative effects of pattern of ultraviolet radiation exposure, and site and histologic type of the first tumor, on the rate of increase in BCC numbers.
  
  
  METHODS
  We used negative binomial regression analysis to study the association of selected variables on the rate of increase in BCC numbers in 266 Caucasian patients who first presented with a tumor on the head/neck or trunk with nodular or superficial histology.
  
  
  RESULTS
  Patients with an initial truncal BCC with superficial histology demonstrated significantly faster increases in BCC numbers than did patients with other site and histology combinations.
  
  
  CONCLUSIONS
  These data indicate that site and histology define subsets of patients with BCC.
authors.affiliation: Human Genomics Research Group, Institute of Science and Technology in Medicine, Keele University School of Medicine, Hartshill Campus, University Hospital of North Staffordshire, United Kingdom.
authors.forename: Tracy J
authors.initials: TJ
authors.lastname: Lovatt
authors.forename: John T
authors.initials: JT
authors.lastname: Lear
authors.forename: Jean
authors.initials: J
authors.lastname: Bastrilles
authors.forename: Christina
authors.initials: C
authors.lastname: Wong
authors.forename: Christopher E M
authors.initials: CE
authors.lastname: Griffiths
authors.forename: Venura
authors.initials: V
authors.lastname: Samarasinghe
authors.forename: Jamie
authors.initials: J
authors.lastname: Roebuck
authors.forename: Sudarshan
authors.initials: S
authors.lastname: Ramachandran
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Smith
authors.forename: Peter W
authors.initials: PW
authors.lastname: Jones
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Fryer
authors.forename: Richard C
authors.initials: RC
authors.lastname: Strange
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology*; D012878:Skin Neoplasms / Q000453:epidemiology / Q000473:pathology*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D044465:White People