title: Interleukin 4, interleukin 6 and interleukin 10 polymorphisms in children with acute and chronic immune thrombocytopenic purpura.
abstract: Immune thrombocytopenic purpura (ITP) is an immune-mediated disorder. We investigated the polymorphisms of interleukin (IL)-4 intron 3, IL-6 (-572 G/C), and IL-10 (-627 C/A) in 50 children with acute ITP, 30 children with chronic TIP, and 100 healthy individuals. There were significant differences in the RP1/RP2 genotype proportion (P = 0.04) and the RP2 allelic frequency (P = 0.03) of IL-4 intron 3 and the A/C genotype proportion (P = 0.01) of IL-10 (-627) between children with chronic ITP and controls. This finding suggests that the IL-4 intron 3 and IL-10 (-627) polymorphisms contribute to the susceptibility of developing childhood chronic ITP.
authors.affiliation: Department of Paediatrics, China Medical University Hospital, Taichung 404, Taiwan.
authors.forename: Kang-Hsi
authors.initials: KH
authors.lastname: Wu
authors.forename: Ching-Tien
authors.initials: CT
authors.lastname: Peng
authors.forename: Tsai-Chung
authors.initials: TC
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Wan
authors.forename: Chang-Hai
authors.initials: CH
authors.lastname: Tsai
authors.forename: Shou-Jen
authors.initials: SJ
authors.lastname: Lan
authors.forename: Ming-Cheng
authors.initials: MC
authors.lastname: Chang
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
mesh_terms: D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005787:Gene Frequency; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D007378:Interleukins / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000235:genetics*
chemical_list: D015850:Interleukin-6; D007378:Interleukins; D016753:Interleukin-10; D015847:Interleukin-4