title: Ductal breast carcinoma develops through different patterns of chromosomal evolution.
abstract: In a previous study that used comparative genomic hybridization (CGH) to analyze 43 ductal breast carcinomas selected for hyperdiploidy, we proposed the existence of two distinct pathways of chromosomal evolution. In the present study, in which we reassessed our cytogenetic findings on 158 ductal breast carcinomas selected for having a modal number of chromosomes of fewer than 60, we confirmed the existence of two subtypes of tumors. Along with the great majority of tumors (142 of 158) that evolved through structural rearrangements with no or very few whole-chromosome gains, we found that a minor subset (16 of 158) evolved through progressive gains of whole chromosomes with no or only a few associated rearrangements. In this article, we describe the karyotypes of these 16 tumors together with data from CGH, which was performed for 10 of them. Chromosomes 5, 7, 8, and 20 were the most frequently gained. Our findings support the evidence of a new pathway of chromosomal evolution in a small subset of ductal breast carcinomas characterized by numerical chromosome aberrations.
authors.affiliation: FRE 2584 CNRS, Institut Curie, Paris, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Molist
authors.forename: Michele
authors.initials: M
authors.lastname: Gerbault-Seureau
authors.forename: Xavier
authors.initials: X
authors.lastname: Sastre-Garau
authors.forename: Brigitte
authors.initials: B
authors.lastname: Sigal-Zafrani
authors.forename: Bernard
authors.initials: B
authors.lastname: Dutrillaux
authors.forename: Martine
authors.initials: M
authors.lastname: Muleris
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005075:Biological Evolution; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D044584:Carcinoma, Ductal / Q000235:genetics / Q000473:pathology*; D002875:Chromosomes; D005260:Female; D006801:Humans; D008875:Middle Aged; D009693:Nucleic Acid Hybridization