Effect of Implanon on insulin resistance in women with Polycystic Ovary Syndrome.
The majority of women with polycystic ovary syndrome (PCOS) have insulin resistance (IR) and have a high risk of developing diabetes. In this retrospective study of women with PCOS, Implanon use was associated with increased insulin resistance, as evidenced by a deterioration in the homeostasis model assessment (HOMA) assessment of insulin resistance, and increased fasting insulin levels. Implanon might increase the risk of diabetes and potentially cardiovascular disease in this already high-risk group. Further research is required to establish the ideal contraceptive preparation in PCOS.
Meyer
Caroline
C
Monash University Department of Vascular Science and Medicine, Dandenong Hospital, Victoria, Australia.
Talbot
Mackenzie
M
Teede
Helena
H
D000328:Adult; D003270:Contraceptive Agents / Q000009:adverse effects*; D017135:Desogestrel / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000139:chemically induced* / Q000209:etiology; D007333:Insulin Resistance / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D012189:Retrospective Studies
D003270:Contraceptive Agents; C044815:etonogestrel; D017135:Desogestrel