title: HIV-1 assembly and budding as targets for drug discovery.
abstract: Research conducted during the past several years has led to an increased understanding of the roles played by the viral protein Gag and specific cellular factors in HIV assembly/budding. The identification of compounds that interfere with this process validates this late step in virus replication as a target for HIV therapeutic discovery. In this review, current understanding of HIV-1 assembly/budding is described and several developmental stage drugs that target this process are reviewed.
authors.affiliation: Panacos Pharmaceuticals Inc, 209 Perry Parkway, Gaithersburg, MD 20877, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Carl
authors.initials: C
authors.lastname: Wild
mesh_terms: D002213:Capsid / Q000187:drug effects; D015683:Gene Products, gag / Q000096:biosynthesis / Q000502:physiology; D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D019251:Nucleocapsid / Q000187:drug effects; D019065:Virus Assembly / Q000187:drug effects*
chemical_list: D015683:Gene Products, gag