title: The differential diagnostic values of cytokine levels in pleural effusions.
abstract: The aim is to examine whether the changes in pleural fluid interleukin (IL)-1beta, IL-2, IL-6, and IL-8 levels were significant in differential diagnosis of childhood pleural effusions. IL-1beta, IL-2, IL-6, and IL-8 levels in pleural fluids of all 36 patients were measured. The levels of IL-1beta, IL-2, IL-6, and IL-8 in pleural fluids were statistically significantly higher in the transudate group compared with those of the exudate group. The levels of IL-1 beta, IL-6, and IL-8 were also found to be statistically significantly higher in the empyema group compared with both the parapneumonic and the tuberculous pleural effusion groups. The levels of IL-2 and IL-6 were detected to be statistically significantly higher in the tuberculous pleural effusion group in comparison with those of the parapneumonic effusion group. The results showed that pleural fluids IL-1beta, IL-2, IL-6, and IL-8 could be used in pleural fluids exudate and transudate distinction.
authors.affiliation: Department of Pediatrics, Medical faculty, Firat university, Elazig, Turkey. akarsu@firat.edu.tr
authors.forename: Saadet
authors.initials: S
authors.lastname: Akarsu
authors.forename: A Nese Citak
authors.initials: AN
authors.lastname: Kurt
authors.forename: Yasar
authors.initials: Y
authors.lastname: Dogan
authors.forename: Erdal
authors.initials: E
authors.lastname: Yilmaz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Godekmerdan
authors.forename: A Denizmen
authors.initials: AD
authors.lastname: Aygun
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000032:analysis* / Q000378:metabolism; D003937:Diagnosis, Differential; D016724:Empyema, Pleural / Q000150:complications / Q000175:diagnosis / Q000378:metabolism; D005122:Exudates and Transudates / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000032:analysis; D006801:Humans; D006836:Hydro-Lyases / Q000032:analysis; D007223:Infant; D008297:Male; D010996:Pleural Effusion / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D011014:Pneumonia / Q000150:complications / Q000378:metabolism; D011237:Predictive Value of Tests; D011506:Proteins / Q000032:analysis; D014396:Tuberculosis, Pleural / Q000150:complications / Q000378:metabolism
chemical_list: D016207:Cytokines; D011506:Proteins; D006836:Hydro-Lyases; C045581:lactate dehydratase; D005947:Glucose