title: Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis.
abstract: In mammals, 14 members of the Eph receptor tyrosine kinase family have been described so far. Here we present a not yet described member of this family denoted EphA10. We report the identification of three putative EphA10 isoforms: one soluble and two transmembrane isoforms. One of the latter isoforms lacked the sterile alpha motif commonly found in Eph receptors. The gene encoding EphA10 is located on chromosome 1p34 and expression studies show that EphA10 mRNA is mainly expressed in testis. Binding studies to ephrin ligands suggests that this receptor belongs to the EphA subclass of Eph receptors binding mainly to ephrin-A ligands.
authors.affiliation: Department of Immunology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway. h.c.asheim@labmed.uio.no
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Aasheim
authors.forename: Sebastian
authors.initials: S
authors.lastname: Patzke
authors.forename: Hanne Sagsveen
authors.initials: HS
authors.lastname: Hjorthaug
authors.forename: Eivind Farmen
authors.initials: EF
authors.lastname: Finne
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D036081:Receptors, Eph Family / Q000032:analysis / Q000737:chemistry / Q000145:classification*; D013737:Testis / Q000201:enzymology*
chemical_list: D036081:Receptors, Eph Family