A possible mechanism of neonatal intrahepatic cholestasis caused by citrin deficiency.
For this study, we investigated why cholestasis develops into neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD), and concluded that primary mitochondrial impairment associated with the delayed maturity of bile acid metabolism may contribute to the occurrence of NICCD.
Tazawa
Yusaku
Y
Department of Pediatrics, National Hospital Organization Sendai Medical Center, Miyagino 2-8-8, Miyagino-Ku, Sendai 983-8520, Japan.
Abukawa
Daiki
D
Sakamoto
Osamu
O
Nagata
Ikuo
I
Murakami
Jun
J
Iizuka
Toshiyuki
T
Okamoto
Manabu
M
Kimura
Akihiko
A
Kurosawa
Takao
T
Iinuma
Kazuie
K
Kobayashi
Keiko
K
Saheki
Takeyori
T
Ohura
Toshihiro
T