Absence of association of inherited thrombophilia with unexplained third-trimester intrauterine fetal death.
OBJECTIVE
The purpose of this study was to investigate the alleged association between thrombophilia and unexplained third-trimester stillbirth.


METHODS
Case subjects were 37 women with a history of a third-trimester unexplained stillbirth. Control subjects were 46 volunteers, group-matched for ethnic origin, with no history of stillbirth, recurrent fetal loss, or thromboembolism. The pathology report of 34/37 placentas of case subjects was reviewed.


RESULTS
The prevalence of at least 1 inherited thrombophilia among case subjects was 37.8% compared with 41.3% among control subjects. (OR = 0.87; 95%CI, 0.32-2.29). There was no significant difference between the groups with respect to the prevalence of any single inherited thrombophilia. There was, however, a significantly higher prevalence of antiphospholipid antibodies among case subjects compared with control subjects: 47.2% vs 8.7%, respectively (OR = 9.4; 95%CI, 2.5-42.3). No significant difference was noted in the prevalence of thrombopilia among subjects with or without placental infarcts.


CONCLUSIONS
We did not find an association between unexplained third-trimester intrauterine fetal death and inherited thrombophilia; however, we did find such an association with antiphospholipid antibodies.
Gonen
Ron
R
Department of Obstetrics and Gynecology, Bnai Zion Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Lavi
Noa
N
Attias
Dina
D
Schliamser
Liliana
L
Borochowitz
Zvi
Z
Toubi
Elias
E
Ohel
Gonen
G
D017152:Antibodies, Antiphospholipid / Q000097:blood; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D006801:Humans; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D015995:Prevalence; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics
D017152:Antibodies, Antiphospholipid