Radical alpha-C-H hydroxyalkylation of ethers and acetal.
[reaction: see text] Epsilonthers and an acetal were found to undergo direct intermolecular addition to aldehydes under the Et(3)B/air conditions. This study presents a very unique and simple means for the radical alpha-C-H hydroxyalkylation of oxygen-containing compounds.
Yoshimitsu
Takehiko
T
Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan. takey@my-pharm.ac.jp
Arano
Yoshimasa
Y
Nagaoka
Hiroto
H
D000080:Acetals / Q000138:chemical synthesis*; D000478:Alkylation; D004987:Ethers / Q000138:chemical synthesis*; D005609:Free Radicals / Q000737:chemistry; D008968:Molecular Conformation
D000080:Acetals; D004987:Ethers; D005609:Free Radicals