title: [Decision making in non resectable head and neck tumours].
abstract: Decision Making in Non Resectable Head and Neck Tumours. Advanced squamous cell carcinomas of the oral cavity, oro-, hypopharynx and larynx often have to be categorised as non resectable disease. Complex decision making for therapy is influenced by morphological, social and ethical aspects. In case of non resectability, simultaneous chemo radiation therapy is evident and recommended. Different substances for additional chemotherapy like Cis-, Carboplatine, 5-Fluorouracile, Mitomycin C and Taxans are in use. Alternatively for selected cases (to avoid total glossectomy for instance) brachytherapy is recommended. Salvage surgery after primary chemo radiation is predominantly common in residual neck disease. Sole chemotherapy is suggested for second or third line palliative treatment.
authors.affiliation: Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde/Plastische Operationen, Universität Leipzig. andreas.dietz@medizin.uni-leipzig.de
authors.forename: A
authors.initials: A
authors.lastname: Dietz
authors.forename: A
authors.initials: A
authors.lastname: Weber
authors.forename: R
authors.initials: R
authors.lastname: Dollner
authors.forename: G
authors.initials: G
authors.lastname: Hildebrandt
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001918:Brachytherapy; D016190:Carboplatin / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003657:Decision Making; D005472:Fluorouracil / Q000627:therapeutic use; D005544:Forecasting; D006257:Head / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D015201:Meta-Analysis as Topic; D016685:Mitomycin / Q000627:therapeutic use; D009055:Mouth / Q000473:pathology; D009367:Neoplasm Staging; D010166:Palliative Care; D011879:Radiotherapy Dosage; D016032:Randomized Controlled Trials as Topic
chemical_list: D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D016685:Mitomycin; D016190:Carboplatin; D002945:Cisplatin; D005472:Fluorouracil