title: Tumor angiogenesis and dynamic CT in colorectal carcinoma: radiologic-pathologic correlation.
abstract: OBJECTIVE
  To investigate the correlation between microvessel density and spiral CT perfusion imaging in colorectal carcinoma.
  
  
  METHODS
  Thirty-seven patients, with histologically proven colorectal carcinoma, underwent water enema spiral CT scan. The largest axial surface of the primary tumor was searched on unenhanced spiral CT images. At this level, the enhanced dynamic scan series was acquired. Time-density curves (TDC) were created from the region of interest drawn over the tumor, target artery by Toshiba Xpress/SX spiral CT with perfusion functional software. Then the perfusion was calculated. Microvessel density (MVD) was evaluated using immunohistochemical staining of surgical specimens with anti-CD34, and then MVD was correlated with perfusion.
  
  
  RESULTS
  MVD of colorectal carcinomas was 33.11-173.44, mean 87.28, and perfusion was 15.60-64.80 mL/min/100 g, mean 39.74 mL/min/100 g. MVD and perfusion were not associated with invasive depth, metastasis and disease stage, and they all decreased with increasing Dukes' stage, but no significant correlation was found between them (r = 0.18, P = 0.29).
  
  
  CONCLUSIONS
  There is no significant correlation between MVD and perfusion. Neovascularizaton and perfusion are highly presented in early colorectal carcinoma. CT perfusion imaging may be more suited for assessing tumorigenesis in colorectal carcinoma than histological MVD technique.
authors.affiliation: Department of Radiology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China. liziping163@163.net
authors.forename: Zi-Ping
authors.initials: ZP
authors.lastname: Li
authors.forename: Quan-Fei
authors.initials: QF
authors.lastname: Meng
authors.forename: Can-Hui
authors.initials: CH
authors.lastname: Sun
authors.forename: Da-Sheng
authors.initials: DS
authors.lastname: Xu
authors.forename: Miao
authors.initials: M
authors.lastname: Fan
authors.forename: Xu-Feng
authors.initials: XF
authors.lastname: Yang
authors.forename: Dong-Ying
authors.initials: DY
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000473:pathology*; D013194:Staining and Labeling; D036542:Tomography, Spiral Computed