title: Consensus based validation of membrane porins.
abstract: Porins are outermembrane beta-barrel proteins. They have varied biological functionality ranging from phage receptors, immunogenicity, pathogenicity to apoptosis. However, only a small number has been structurally and functionally characterised. A validation mechanism and a database of porins would be useful for target selection in proteomics and structural genomics work. Here we report a validation mechanism developed for membrane porins. A database server for porins, PRNDS, has been created containing experimentally proven porins and likely putative porins. Each porin is validated and ranked using a weighted scoring system developed based on six, structure and sequence based criteria. The server also predicts possible porins.
authors.affiliation: Bioinformatics Centre, School of Biotechnology, Madurai Kamaraj University, Madurai-625 021, India.
authors.forename: A V S K Mohan
authors.initials: AV
authors.lastname: Katta
authors.forename: Rajeshwari
authors.initials: R
authors.lastname: Marikkannu
authors.forename: Rajiv V
authors.initials: RV
authors.lastname: Basaiawmoit
authors.forename: Sankaran
authors.initials: S
authors.lastname: Krishnaswamy
mesh_terms: D000595:Amino Acid Sequence; D019295:Computational Biology / Q000379:methods*; D016384:Consensus Sequence; D030562:Databases, Protein; D023281:Genomics / Q000379:methods; D018272:Porins / Q000737:chemistry* / Q000235:genetics; D040901:Proteomics / Q000379:methods
chemical_list: D018272:Porins