[Gene therapy for peripheral arterial diseases].
Therapeutic angiogenesis using angiogenic growth factor is expected to be a new treatment for with patients with critical limb ischemia. The first human clinical trial treating peripheral vascular disease was started in 1994 using vascular endothelial growth factor (VEGF). To date, other potent angiogenic growth factors, such as fibroblast growth factor(FGF) or hepatocyte growth factor(HGF), have been also estimated in clinical trials for peripheral arterial disease. Several results from phase 1 or 2 trials using VEGF, FGF and HGF gene were encouraging. Phase 3 trials are now ongoing and their results are expected.
Makino
Hirofumi
H
Department of Geriatric Medicine, Osaka University Medical School.
Ogihara
Toshio
T
Morishita
Ryuichi
R
D000368:Aged; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013919:Thromboangiitis Obliterans / Q000628:therapy*