title: [Study on metronidazole resistance to Helicobacter pylori from three populations with different ethnics in Yunnan].
abstract: OBJECTIVE
  To evaluate the prevalence of Helicobacter pylori (H.pylori) resistance to metronidazole among three populations in Yunnan.
  
  
  METHODS
  Susceptibilities to metronidazole among 109 H. pylori strains (33 H. pylori strains from Han, 31 H. pylori strains from Bai and 45 H. pylori strains from Naxi ethnic populations) were tested by Epsilometer test (E-test).
  
  
  RESULTS
  In 109 H. pylori strains, the overall metronidazole resistance rate was 67.89%. There were no significant difference in the metronidazole resistant rates of H. pylori among Han, Bai, Naxi populations Yunnan in terms of the distribution on age and upper gastroduodenal diseases. In the facet of gender, metronidazole resistant rate of H. pylori was significantly lower in Han males than in females (chi2=5.304, P=0.027), but not seen in the Bai or Naxi peoples.
  
  
  CONCLUSIONS
  Metronidazole resistance rate of H. pyloriin Yunnan was high, but no significant difference was found among Han, Bai, Naxi peoples in the province.
authors.affiliation: Digestive Department, the First Affiliated Hospital, Kunming Medical College, Kunming 650032, China.
authors.forename: Yue-Yan
authors.initials: YY
authors.lastname: Hu
authors.forename: Zeng-Fen
authors.initials: ZF
authors.lastname: Zhou
authors.forename: Qiong
authors.initials: Q
authors.lastname: Nan
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Jiang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Li
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Duan
authors.forename: Ya-Rong
authors.initials: YR
authors.lastname: Chen
mesh_terms: D000328:Adult; D002681:China / Q000208:ethnology; D002908:Chronic Disease; D024881:Drug Resistance, Bacterial; D005260:Female; D005756:Gastritis / Q000382:microbiology*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D010437:Peptic Ulcer / Q000382:microbiology
chemical_list: D008795:Metronidazole