Cyclin I is expressed in human breast cancer and closely associated with VEGF and KDR expression.
In the present study, cyclin I protein expression in 114 invasive human breast cancers was correlated with cell cycle and angiogenesis-related proteins and clinico-pathological data. A strong association was found between cytoplasmic cyclin I staining and VEGF (p = 0.001) as well as the VEGF receptor KDR (p = 0.001), suggesting a link between cyclin I and angiogenesis.
Landberg
Göran
G
Division of Pathology, Department of Laboratory Medicine, U-MAS, Lund University, Malmö, Sweden.
Nilsson
Kristina
K
Jirström
Karin
K
Rydén
Lisa
L
Kitching
Richard
R
Burger
Angelika M
AM
Seth
Arun
A
D000595:Amino Acid Sequence; D001483:Base Sequence; D001943:Breast Neoplasms / Q000378:metabolism*; D056749:Cyclin I; D016213:Cyclins / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007124:Immunoenzyme Techniques; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*
C534756:CCNI protein, human; D056749:Cyclin I; D016213:Cyclins; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2