[A gene involved in angiogenesis and bone -osteopontin].
Osteopontin is expressed in bone and stored in hard tissues while it promoted survival of endothelial cells and enhances angiogenesis towards bone in ectopic implantation experiments. As regulation of bone remodeling in osteoporosis and other metabolic bone diseases is an important issue and is influenced by the interaction between bone and vessels. Molecular mechanisms involved in the angiogenesis in bone should be further investigated.
Noda
Masaki
M
Department of Molecular Pharmacology Medical Research Institute, Tokyo Medical and Dental University.
Tsuji
Kunikazu
K
Morinobu
Mikihiko
M
Ishijima
Muneaki
M
Nifuji
Akira
A