Isolation of isomers based on hydrogen/deuterium exchange in the gas phase.
A method to isolate isomers in a Fourier transform ion cyclotron resonance mass spectrometer on the basis of their different hydrogen/deuterium exchange rates has been developed and applied to the protonated serine octamer cluster. Isolation allows interrogation of each isomer by infrared multi-photon dissociation to determine any differences in the building blocks that form these clusters. The experimental results strongly support previous assignments of an all-zwitterion structure to the slower-exchanging isomer and an all-neutral structure to its faster- exchanging counterpart.
Mazurek
Ulf
U
Department of Physical Chemistry and The Farkas Center for Light Induced Processes, The Hebrew University of Jerusalem, Giv'at Ram, Jerusalem 91904, Israel. ykv@chem.ch.huji.ac.il
McFarland
Melinda A
MA
Marshall
Alan G
AG
Lifshitz
Chava
C
D003903:Deuterium / Q000737:chemistry*; D005740:Gases / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D007536:Isomerism; D012694:Serine / Q000032:analysis*; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared
D005740:Gases; D012694:Serine; D006859:Hydrogen; D003903:Deuterium