title: [Change in humoral immunological function and their clinical significance in patients with cerebral hemorrhage].
abstract: OBJECTIVE
  To study the changes in humoral immunological function and their clinical significance in cerebral hemorrhage.
  
  
  METHODS
  Among 115 cases of cerebral hemorrhage, there was low volume bleeding in 39 case, middle volume in 37 cases, and large volume in 39 cases. The ratios of CD19+-CD25+ and CD19+-CD25-B lymphocytes were determined by flow cytometry, and the content of IgA, IgG, IgM, and complement C3 were determined with scattered turbidimetry. The changes in humoral immunological function were compared in patients with different degrees of hemorrhage, and their variation in acute and recovery stages of disease were respectively assessed.
  
  
  RESULTS
  The ratios of CD19+-CD25+and CD19+-CD25-B lymphocyte, and the levels of IgA, IgG, IgM, and C3 were higher than those of controls (all P<0.05). The ratios of CD19+-CD25+ and CD19+-CD25- B lymphocyte, and the contents of IgA, IgG,IgM and C3 were increased with the increase in amount of hemorrhage(all P<0.05). The ratios of CD19+-CD25+ and CD19+-CD25-B lymphocytes in recovery stage were lower than those in acute stage (all P<0.05).
  
  
  CONCLUSIONS
  There are activations of humoral immunological functions in cerebral hemorrhage. The more abundant in hemorrhage and the severer in disease, the more predominant in the changes in humoral immunological functions.
authors.affiliation: Jinhua Municipal Central Hospital, Jinhua 321000, Zhejiang, China.
authors.forename: Hong-fang
authors.initials: HF
authors.lastname: Chen
authors.forename: Xiang-mei
authors.initials: XM
authors.lastname: Wang
authors.forename: Jian-qin
authors.initials: JQ
authors.lastname: Luo
authors.forename: Zhao-jing
authors.initials: ZJ
authors.lastname: Zheng
authors.forename: Ren-di
authors.initials: RD
authors.lastname: Wu
authors.forename: Rui-long
authors.initials: RL
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000917:Antibody Formation / Q000276:immunology*; D002543:Cerebral Hemorrhage / Q000276:immunology*; D003176:Complement C3 / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D008875:Middle Aged
chemical_list: D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M