Alveolar ridge augmentation with a prototype trilayer membrane and various bone grafts: a histomorphometric study in baboons.
Barrier membranes have become a standard treatment option in alveolar ridge augmentation prior to implant placement. However, non-resorbable membranes require secondary surgery and resorbable membranes show an unfavorable degradation profile. The purpose of this study was to evaluate the potential of a slowly biodegradable/bioresorbable prototype trilayer membrane (PTLM) for supporting bone regeneration in alveolar ridge augmentation. Clinically relevant cavities were made 3 months after the extraction of the first and second molars in each jaw of six baboons. Each animal was treated with four different regimens: (1) autogenous bone block (ABB) alone, (2) ABB+PTLM, (3) deproteinized bovine bone mineral (DBBM)+PTLM and (4) no treatment. After 9 months, the baboons were sacrificed and block sections of the augmented area were subjected to histologic and histomorphometric analyses. Newly formed bone areas were determined at a distance of 1, 3, 7 and 10 mm from crestal. The data showed a well-preserved ridge profile at the membrane-protected sites, whereas non-protected bone blocks and control sites underwent severe resorption resulting in knife-edge ridge profiles. Significant differences were found between ABB+PTLM and ABB (P=0.0137-0.0232). DBBM+PTLM also produced a larger bone area compared with ABB alone (P=0.0396-0.0439). No significant difference in bone area was detectable between ABB+PTLM and DBBM+PTLM (P>0.05). The present study supports the use of the slowly biodegradable/bioresorbable PTLM with autografts and DBBM for lateral ridge augmentation in this type of bone defects.
Busenlechner
Dieter
D
Department of Oral Surgery, Vienna Medical University School of Dentistry, Ludwig Boltzmann Institute of Oral Implantology, Waehringerstrasse 25a, A-1090 Vienna, Austria. dieter.busenlechner@univie.ac.at
Kantor
Markus
M
Tangl
Stefan
S
Tepper
Gabor
G
Zechner
Werner
W
Haas
Robert
R
Watzek
Georg
G
D020341:Absorbable Implants; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008297:Male; D008567:Membranes, Artificial; D010215:Papio
D018786:Bone Substitutes; D008567:Membranes, Artificial