title: Leptin in immunology.
abstract: Leptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. As a cytokine, leptin also affects thymic homeostasis and, similar to other proinflammatory cytokines, leptin promotes Th1 cell differentiation and cytokine production. We review herein recent advances on the role of leptin in the pathophysiology of immune responses.
authors.affiliation: Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimenttale, Consiglio Nazionale delle Ricerche, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Matarese
authors.forename: Stergios
authors.initials: S
authors.lastname: Moschos
authors.forename: Christos S
authors.initials: CS
authors.lastname: Mantzoros
mesh_terms: D000273:Adipose Tissue / Q000276:immunology / Q000378:metabolism; D000818:Animals; D015551:Autoimmunity; D004734:Energy Metabolism; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000209:etiology / Q000276:immunology; D007249:Inflammation / Q000209:etiology / Q000276:immunology; D020738:Leptin / Q000276:immunology*; D018448:Models, Immunological; D015398:Signal Transduction
chemical_list: D020738:Leptin