Mitosis: PARty time in the spindle.
Poly(ADP-ribose), a post-translational protein modification known to affect chromatin structure, has now been shown to regulate microtubule organization during mitosis. These findings alter conventional views of the mechanisms of spindle assembly and function.
Compton
Duane A
DA
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. duane.a.compton@dartmouth.edu
D018797:Cell Cycle Proteins / Q000378:metabolism; D020090:Chromosome Segregation / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism* / Q000502:physiology; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism* / Q000502:physiology
D018797:Cell Cycle Proteins; D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases