[Influence of acute and chronic administrations of beta-casomorphins on the maternal motivation in albino rats].
The influence of food-derived opioid peptides beta-casomorphines on the manifestation of nursing albino rats maternal behavior was investigated. It was shown that both acute and chronic (during the postnatal period) administration of beta-casomorphin-7 (Tyr-Pro-Phe-Pro-Gly-Pro), the typical representative of this group of peptides, decreases the level of the parental motivation. The effects of beta-casomorphin-7 were naloxone-dependent; N-terminal-reduced analogues had a significantly lesser activity. The obtained results testify in favor of the probable role of casein opioid fragments which were formed in mammary glands of a nursing female, in the development of maternal behavior abnormalities. At the same time, beta-casomorphins could be considered as the limiting factors to the excessive manifestation of the parental motivation.
Dubynin
V A
VA
Ivleva
Iu A
IuA
Beliaeva
Iu A
IuA
Dobriakova
Iu V
IuV
Andreeva
L A
LA
Kamenskiĭ
A A
AA
D000818:Animals; D002364:Caseins / Q000378:metabolism*; D004723:Endorphins / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D005260:Female; D007774:Lactation / Q000502:physiology*; D008425:Maternal Behavior / Q000187:drug effects / Q000502:physiology*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D051381:Rats
D002364:Caseins; D004723:Endorphins; D010446:Peptide Fragments; C041128:beta-casomorphin 7