title: Outcome of patients with hematological malignancies admitted to the intensive care unit with life-threatening complications.
abstract: OBJECTIVE
  To assess the outcome of patients with hematological malignancies (HM) admitted to medical intensive care unit (MICU) and to identify prognostic factors that may affect patients' outcome.
  
  
  METHODS
  Data were collected in 44 patients with HM admitted to the MICU at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia within a 9-year period from 1993 to 2004. Demographic, physiological, clinical, laboratory and therapeutic data were collected on admission to MICU.
  
  
  RESULTS
  Thirty-four percent of the patients had acute lymphocytic leukemia; 25% had acute myelocytic leukemia (AML) followed by non-Hodgkin's lymphoma in 20%, only 13.6% of these patients were in remission. The reasons for admission of these patients into MICU were shock (34.15%), respiratory failure (31.8%), cardiac arrest (20.4%), neurological causes (9.1%) and for other causes like small bowel perforation, hepatic failure, acute renal failure and metabolic disorders (4.5%). The overall in-hospital mortality was 72.7%, intensive care unit (ICU) mortality 61%, and the mean length of stay in the MICU was 5.4 +/- 4.8 days. A statistically significant association was demonstrated between both remission status and aspartate aminotransferase values on one side and patient's outcome on the other side. Patients with AML had poorer prognosis with mortality rate of 90.9%.
  
  
  CONCLUSIONS
  Although mortality in patients with HM requiring ICU care is high, our results indicate that critical care support may be lifesaving. Apart from remission status and AML disease, no other prognostic factor could be identified.
authors.affiliation: Sleep Disorders Center, Respiratory Unit, College of Medicine, Department of Medicine 38, King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia. ashammam@awalnet.net.sa
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Bahammam
authors.forename: Sayed J
authors.initials: SJ
authors.lastname: Basha
authors.forename: Mohammed I
authors.initials: MI
authors.lastname: Masood
authors.forename: Shafi A
authors.initials: SA
authors.lastname: Shaik
mesh_terms: D000328:Adult; D015897:Comorbidity; D003422:Critical Care; D005260:Female; D019337:Hematologic Neoplasms / Q000453:epidemiology / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D015470:Leukemia, Myeloid, Acute / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D012529:Saudi Arabia / Q000453:epidemiology