title: The effect of tiarellic acid on the expressions of matrix metalloproteinase-1 and type 1 procollagen in ultraviolet irradiated cultured human skin fibroblasts.
abstract: Long term and repeated exposure of ultraviolet (UV) light, a harmful environmental stress, on the skin often induces chronic skin diseases such as skin cancer as well as photoaging (premature skin aging), and the mechanisms of these skin damages are closely associated with up-regulation of matrix metalloproteinases (MMPs) activities. Here we investigated the effect of tiarellic acid on the expressions of MMP-1 and type 1 procollagen in ultraviolet irradiation of cultured human skin fibroblasts. Tiarellic acid reduced the expression of MMP-1 and induced the expression of type 1- procollagen at the protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that tiarellic acid plays an important role in the reduction of MMP-1 and induction of type 1- procollagen by ultraviolet irradiation.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, and Clinical Research Institute, Seoul National University Hospital, Youngon-Dong, Chongno-Gu, Seoul 110-744, Republic of Korea. himun@snu.ac.kr
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
authors.forename: Joongku
authors.initials: J
authors.lastname: Lee
authors.forename: Hee Chul
authors.initials: HC
authors.lastname: Eun
authors.forename: Kyu Han
authors.initials: KH
authors.lastname: Kim
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology; D002478:Cells, Cultured; D024042:Collagen Type I / Q000187:drug effects* / Q000235:genetics / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects* / Q000528:radiation effects; D015870:Gene Expression / Q000187:drug effects / Q000235:genetics; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000187:drug effects* / Q000528:radiation effects; D061965:Matrix Metalloproteinase Inhibitors; D010946:Plants, Medicinal / Q000737:chemistry; D012867:Skin / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D013997:Time Factors; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D024042:Collagen Type I; D061965:Matrix Metalloproteinase Inhibitors; D014315:Triterpenes; C464534:tiarellic acid; D002392:Catechin; C045651:epigallocatechin gallate; D020781:Matrix Metalloproteinase 1