title: Effects of fresh versus old stored blood in the priming solution on whole blood lactate levels during paediatric cardiac surgery.
abstract: It has been suggested that lactate levels may predict morbidity and mortality in paediatric patients during corrective open-heart surgery. Packed red blood cells (PRBC) are frequently necessary for priming the reservoir used in cardiopulmonary bypass (CPB). The storage of PRBC might cause a significant increase in lactate levels. The purpose of the present study was to quantify the increase in lactate levels in stored red blood cells over time and to compare lactate levels after transfusions of fresh (< or =12 days) versus old blood (>12 days) in 20 patients. We found an increase in lactate levels from 6.0 to 44.7mmol/L (mean 17.0+/-7.8 mmol/L) during storage. Lactate levels were also significantly higher after the onset of CPB in paediatric patients transfused with old blood than in patients transfused with fresh blood (1.43+0.36 versus 3.46+/-0.63, p=0.0006). Our results suggest that the higher lactate levels found after the initiation of CPB should be used with caution when assessing tissue hypoxia and predicting outcome.
authors.affiliation: Department of Anesthesiology and Transfusion Medicine, Tuebingen University Hospital, Tuebingen, Germany. torsten.schroeder@uni-tuebingen.de
authors.forename: Torsten H
authors.initials: TH
authors.lastname: Schroeder
authors.forename: Matthias
authors.initials: M
authors.lastname: Hansen
mesh_terms: D001793:Blood Preservation; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000379:methods; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007223:Infant; D019344:Lactic Acid / Q000032:analysis / Q000097:blood*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019344:Lactic Acid