Effect of compatibility on the pharmacokinetic characteristics of ginsenosides.
Pharmacokinetic research, which is one of the most important parts of preclinic research, plays an important role in guiding medicine compatibility and preparation improvement. In this paper, the influence of the compatibility of GGV on pharmacokinetics of ginsenosides (GS) was studied, which consisted of ginsenosides, ginkgo biloba extract (GBE) and a chemical monomer V. The result indicated that the addition of either GBE or V could influence the pharmacokinetic parameters of ginsenosides and the influence was different when different administering routes were adopted. Therefore, it could be concluded that there are interactions among GS, GBE and V, and the synergetic and inhibitory effects of the three ingredients contribute to the pharmacological effect of GGV.
Bochu
Wang
W
Key Laboratory for Biomechanics and Tissue Engineering under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. wangbc2000@126.com
Jie
Liu
L
Liancai
Zhu
Z
D000818:Animals; D004347:Drug Interactions; D004357:Drug Synergism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D020441:Ginkgo biloba / Q000737:chemistry*; D036145:Ginsenosides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008516:Medicine, Chinese Traditional; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits
D004791:Enzyme Inhibitors; D036145:Ginsenosides; D010936:Plant Extracts