Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography.
Green laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser were employed as irradiation sources for photoacoustic tomography (PAT). The vascular structure of the brain was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. Brain tumors can be identified based on the distorted vascular architecture of brain tumorigenesis and related vascular changes, such as hemorrhage. This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research.
Ku
Geng
G
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A&M University, 3120 TAMU, College Station, Texas 77843-3120, USA. gku@oilab.tamu.edu
Wang
Xueding
X
Xie
Xueyi
X
Stoica
George
G
Wang
Lihong V
LV
D000162:Acoustics / Q000295:instrumentation; D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging*; D004453:Echoencephalography / Q000295:instrumentation / Q000379:methods*; D007834:Lasers; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D051381:Rats; D014054:Tomography / Q000295:instrumentation / Q000379:methods*; D014732:Vibration