Therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation in rats.
OBJECTIVE
To investigate the therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation.


METHODS
108 Wistar rats weighing (200 g+/-30 g) were randomly divided into a sham shock (SS) group (n=36), a hemorrhagic shock resuscitation (HS) group (n=36) and a hemorrhagic shock cisapride treated (HSC) group (n=36). Sampling at 1, 2 and 4 hours after resuscitation was done and 6 samples for each observation item were taken. The gastric blood flow volume was measured by isotope label biological microglobulin. Gastric pHi, gastric emptying, MDA and Na+-K+-ATPase of gastric mucosa were measured.


RESULTS
In the HSC group, the relative residual rate of gastric pigment decreased significantly, the gastric blood flow volume elevated; gastric pHi increased significantly at 2 hours; the level of mucosal MDA decreased at 4 hours, the activity of Na+-K+-ATPase increased and the lactic acid level in the portal vein decreased significantly compared to the HS group.


CONCLUSIONS
After hemorrhagic shock resuscitation, cisapride contained the following functions, 1) promoting gastric emptying, 2) increasing the blood flow of gastric blood flow volume and gastric pHi, 3) depressing the lactic acid concentration of the portal vein and improving MDA volume and Na+-K+-ATPase activity of gastric mucosa. It suggests that after complementing effective circulating blood volume for hemorrhagic shock resuscitation, early use of cisapride for gastric motility is helpful for an improvement of lasting ischemia and hypoxia in stomach.
Zhang
Lian-yang
LY
General Surgery Department, Daping Hospital, Research Institute of Field Surgery, Third Military Medical University, Chongqing 400042, China. hpzhangly@163.com
Wang
Zheng-guo
ZG
Zhu
Pei-fang
PF
Xu
Yan
Y
D000818:Animals; D020117:Cisapride / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005746:Gastric Emptying / Q000187:drug effects; D005753:Gastric Mucosa / Q000737:chemistry / Q000201:enzymology; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000150:complications* / Q000628:therapy*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013270:Stomach / Q000098:blood supply / Q000473:pathology; D013272:Stomach Diseases / Q000188:drug therapy* / Q000209:etiology*
D005765:Gastrointestinal Agents; D000254:Sodium-Potassium-Exchanging ATPase; D020117:Cisapride