[Sporadic cerebral amyloid angiopathy with ischemic leukoencephalopathy and microbleeds. Cause for a rapidly progressive dementia syndrome].
We describe a 72-year-old patient with rapidly progressive dementia and a complex focal seizure. Magnetic resonance (MR) imaging revealed leukoencephalopathy with the involvement of the U-fibers as well as cortical and subcortical microbleeds. Brain biopsy confirmed the diagnosis of cerebral Abeta amyloid angiopathy (CAA). The presented case illustrates the significance of CAA as a cause of rapidly progressive dementia and leukoencephalopathy and points out the importance of T2-weighted MR imaging in the evaluation of dementia.
Katchanov
J
J
Klinik für Neurologie, Universitätsmedizin Charité, Berlin. juri.katchanov@charite.de
Bohner
G
G
Könneker
M
M
Kopp
U
U
Izadpanah
K
K
Larmann
E
E
Klingebiel
R
R
van Landeghem
F
F
Masuhr
F
F
Zschenderlein
R
R
D000368:Aged; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis*; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000175:diagnosis*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis*; D003704:Dementia / Q000175:diagnosis* / Q000209:etiology; D018450:Disease Progression; D006801:Humans; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000150:complications / Q000175:diagnosis*; D008297:Male; D013577:Syndrome