title: Formalin-induced pain is reduced in sigma(1) receptor knockout mice.
abstract: The role of sigma1 receptors in non-acute pain has not been explored. In this study we show that both phases of formalin-induced pain were reduced by approximately 55% in sigma1 receptor knockout mice in comparison to wild-type animals. These results suggest that the tonic pain induced by formalin is altered in mice lacking sigma1 receptors, and highlight the potential usefulness of further studies of the role of sigma1 receptors in models of non-acute pain.
authors.affiliation: Department of Pharmacology and Institute of Neurosciences, School of Medicine, University of Granada, Avenida de Madrid 12, 18012 Granada, Spain.
authors.forename: Cruz Miguel
authors.initials: CM
authors.lastname: Cendán
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Pujalte
authors.forename: Enrique
authors.initials: E
authors.lastname: Portillo-Salido
authors.forename: Lluís
authors.initials: L
authors.lastname: Montoliu
authors.forename: José M
authors.initials: JM
authors.lastname: Baeyens
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D005557:Formaldehyde; D005838:Genotype; D006614:Hindlimb / Q000187:drug effects / Q000503:physiopathology; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D017480:Receptors, sigma / Q000235:genetics / Q000502:physiology*; D013997:Time Factors; D000097605:Sigma-1 Receptor
chemical_list: D005557:Formaldehyde; D017480:Receptors, sigma; D000097605:Sigma-1 Receptor