[To the question of the possibility of oral insulin administration].
The influence of oral insulin upon carbohydrate exchange in healthy volunteers was evaluated. One of the two forms of insulin used in the study was insulin, immobilized in a volume of polyacrylamide gel, modified by ovomucoid (proteolytic enzyme inhibitor), isolated from duck eggs; the other form was enteric-coated tablets bases on hydrogel substance. The oral administration of the hydrogel substance or the tablets resulted in the fall of blood glucose concentration by 34.9 +/- 4.4% and 28.6 +/- 6.9%, respectively. The maximal effect of the hydrogel substance and the tablets was observed at the 90th and the 180th minutes.
Grigor'ev
A I
AI
Plate
N A
NA
Valuev
L I
LI
Sytov
G A
GA
Goncharova
A G
AG
D000284:Administration, Oral; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D050260:Carbohydrate Metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D007328:Insulin / Q000008:administration & dosage* / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D013607:Tablets; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D013607:Tablets; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate