title: [Clinicopathological and immunohistochemical study of oral teratoid cyst].
abstract: OBJECTIVE
  To investigate clinicopathological and immunohistochemical features of 31 cases of oral teratoid cyst.
  
  
  METHODS
  Thirty-one cases of oral teratoid cyst according with Meyer's diagnosis criteria were retrospectively studied and their histochemistry and immunohistochemistry were performed from the files of Department of Pathology, School of Stomatology, Wuhan University between 1963 and 2003.
  
  
  RESULTS
  Twenty-seven cases (87.10%) were children, and twenty-four cases were congenital. The ratio of male-to-female was 1:0.55, and the affected sites were floor of mouth (22 cases) and tongue (8 cases). Clinical findings were nonspecific, and prognosis was good following complete excision. Histology indicated that squamous, respiratory and/or gastrointestinal epithelium consistiuted basic structure of teratoid cyst in addition to simple cuboidal epithelium in 8 cases. Antibody against AE1/AE3 was strongly expressed and CK16 was weak in four types of epithelial lining of oral teratoid cyst. Expression of AE1, CK7, 8/18, 19 varied in superficial, suprabasal and basal cells of squamous epithelium but were strong in respiratory, gastrointestinal and simple columnar epithelium; only gastrointestinal epithelium expressed CK20 heterogeneously.
  
  
  CONCLUSIONS
  Oral teratoid cyst showed the highest incidence in children, and floor of mouth and tongue were mostly affected sites. Features of histology were complex, and immunohistochemistry indicated that epithelium of oral teratoid cyst shared similar patterns of cytokeratin with counterpart of normal tissues, showing different origin and differentiation of epithelial lining of the present cyst.
authors.affiliation: Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School of Stomatology, Wuhan University, Wuhan 430079, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shen
authors.forename: Xin-ming
authors.initials: XM
authors.lastname: Chen
authors.forename: Shuo-zhi
authors.initials: SZ
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Shi-chun
authors.initials: SC
authors.lastname: Xiong
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007633:Keratins / Q000378:metabolism; D008297:Male; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies; D013724:Teratoma / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
chemical_list: D007633:Keratins