[Study on the distribution of serum homocysteine and on multi-stepwise regression analysis of the associated factors in the population of community areas in Wuhan].
OBJECTIVE
To study the serum homocysteine (Hcy) distribution and characteristics in different sex and age groups in the community residents in Wuhan, and to analyse its associated factors with multi-stepwise regression analysis.


METHODS
The population under study was from three community areas in Wuhan. Demographic distribution and the correlation with other risk factors of serum Hcy were analyzed statistically.


RESULTS
(1) Geometric mean of serum Hcy was 14.43 micromol/L in males and 10.89 micromol/L in females with P <0.001. (2) Hcy of per age level in males was also higher (P <0.001). (3) The prevalence rate of hyperhomocysteinemia was 23.94% in the general population in Wuhan. The prevalence rate of hyperhomocysteinemia in males was 2.62 times higher than in females. (4) Multi-stepwise regression analysis showed that Hcy had different affecting factors in males and females. The affecting factors of Hcy in males were daily cigarettes smoking, urine micro-albumin (UMALB) and times of exercise per week. The affecting factors of Hcy in females were duration of exercise each time, weight, triglyceride (TG), high-density lipoprotein (HDL), urine micro-albumin (UMALB) and age.


CONCLUSIONS
(1) Hcy at the population level was significantly different by sex and age. (2) Population living in the community in Wuhan had a higher serum level and prevalence rate of Hcy comparing to some other cities in China and even in developed countries. (3) The important affecting factors of Hcy in population also showed sex difference, unlike the reports from other countries or other areas in China. Serum Hcy seemed to be affected by environmental and other factors.
Hu
Chun-ping
CP
Department of Cardiology, Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology, Wuhan 430030, China.
Shao
Jiao-mei
JM
Yan
Jiang-tao
JT
Fan
Qiao
Q
Liu
Zhen-jun
ZJ
Tian
Cheng
C
Wu
Hai-lin
HL
Li
Xiao-ping
XP
Wang
Dao-wen
DW
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002681:China; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D044382:Population Groups; D012016:Reference Values; D012044:Regression Analysis; D012737:Sex Factors
D006710:Homocysteine