Targets for antiageing drugs.
The process of ageing denotes a postmaturational deterioration of cells and organisms with the passage of time, an increased vulnerability to challenges and a decreased ability to survive. Causes may be found in oxidative damage and incomplete cell maintenance, and both of these factors may be considered the primary targets of any antiageing therapy. Levels of lipophylic anti-oxidant defences may be the limiting factor of longevity in ad-libitum fed animals. An appropriate administration of lipophylic antioxidants (e.g., polyunsaturated fatty acids, vitamin E) and the stimulation of cytomembrane and organelle renewal, by calorie restriction and pharmacological intensification of autophagy, are currently available interventions that may extend longevity and retard the onset, as well as aid the treatment, of most age-associated diseases.
Bergamini
Ettore
E
University of Pisa, Centro di Ricerca Interdipartimentale di Biologia e Patologia dell'Invecchiamento, via Roma 55, 56126 Pisa, Italy. ebergami@med.unipi.it
D000375:Aging / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology
D000975:Antioxidants