title: Group 2A idiopathic juxtafoveolar retinal telangiectasia in monozygotic twins.
abstract: OBJECTIVE
  To report the clinical and fluorescein angiographic characteristics of monozygotic twins affected by group 2A idiopathic juxtafoveolar retinal telangiectasia.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  Both eyes of identical twins were examined in a clinical practice setting.
  
  
  RESULTS
  Two 68-year-old Caucasian, monozygotic, female twins were examined. In one twin, visual acuity was 20/50 in the right eye (OD) and 20/40 in the left (OS). Ophthalmoscopy demonstrated right-angle venules without edema in both eyes (OU). Fluorescein angiography demonstrated areas of leakage temporal to the fovea OU with some nasal leakage OS. In her identical twin sister, with type II diabetes, visual acuity was 20/60 OD and 20/25 OS. Right-angle venules OU, refractile deposits OS, and no macular edema OU were present. Fluorescein angiography demonstrated areas of parafoveal leakage temporal and nasal OD and temporal OS.
  
  
  CONCLUSIONS
  This is the second set of female monozygotic twins with group 2A idiopathic juxtafoveolar retinal telangiectasia reported in the literature. This finding suggests a genetic component in the pathogenesis of this retinal vascular disease.
authors.affiliation: Department of Ophthalmology of the Duke University Medical Center, Durham, North Carolina 27710-3802, USA.
authors.forename: Nouman
authors.initials: N
authors.lastname: Siddiqui
authors.forename: Sharon
authors.initials: S
authors.lastname: Fekrat
mesh_terms: D000368:Aged; D004200:Diseases in Twins; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000473:pathology; D006801:Humans; D012164:Retinal Diseases / Q000175:diagnosis / Q000235:genetics*; D012171:Retinal Vessels / Q000473:pathology*; D013684:Telangiectasis / Q000175:diagnosis / Q000235:genetics*; D014430:Twins, Monozygotic; D014792:Visual Acuity