[Evaluation of diagnostic criteria of syphilitic infection by means of gas chromatography and mass-spectrometry].
In order to estimate possibility of chromatographic criteria application in diagnostics of syphilitic infection, the authors researched in three directions: evaluation of dysmetabolism of carbohydrate, lipid and amino acid components in patients' serum; search of signal compounds that serve as microbe "cooperative sensitivity" activators (lactones, quinolones, furan boron ethers) with evaluation of the risk of luetic infection generalization; indication of organ lesion markers (the brain, liver, bone structures). The factor analysis performed by the researchers allowed to determine priorities of clinical, laboratory and chromatographic data according to their value. The diagnostic value of various diagnostic chromatographic criteria was estimated as follows: the diagnostic sensitivity was 79.6% to 97.2%, the diagnostic specificity was 50.0% to 92.7%, the positive diagnostic predictability was 61.8% to 94.7% and the negative diagnostic predictability was 60.9% to 95.1%.
Vorob'ev
A A
AA
Mironov
A Iu
AIu
Istratov
V G
VG
Osman
K A
KA
D000596:Amino Acids / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D002849:Chromatography, Gas / Q000379:methods*; D006801:Humans; D008055:Lipids / Q000097:blood*; D013058:Mass Spectrometry / Q000379:methods*; D012680:Sensitivity and Specificity; D013587:Syphilis / Q000097:blood / Q000175:diagnosis*
D000596:Amino Acids; D001786:Blood Glucose; D008055:Lipids