title: Degradation of 1,4-dioxane and cyclic ethers by an isolated fungus.
abstract: By using 1,4-dioxane as the sole source of carbon, a 1,4-dioxane-degrading microorganism was isolated from soil. The fungus, termed strain A, was able to utilize 1,4-dioxane and many kinds of cyclic ethers as the sole source of carbon and was identified as Cordyceps sinensis from its 18S rRNA gene sequence. Ethylene glycol was identified as a degradation product of 1,4-dioxane by the use of deuterated 1,4-dioxane-d8 and gas chromatography-mass spectrometry analysis. A degradation pathway involving ethylene glycol, glycolic acid, and oxalic acid was proposed, followed by incorporation of the glycolic acid and/or oxalic acid via glyoxylic acid into the tricarboxylic acid cycle.
authors.affiliation: Endocrine Disrupters and Dioxins Research Project, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan. Nakamiya.Kunichika@nies.go.jp
authors.forename: Kunichika
authors.initials: K
authors.lastname: Nakamiya
authors.forename: Syunji
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ito
authors.forename: John S
authors.initials: JS
authors.lastname: Edmonds
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Morita
mesh_terms: D001673:Biodegradation, Environmental; D032661:Cordyceps / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D004271:DNA, Fungal / Q000235:genetics; D004146:Dioxanes / Q000378:metabolism*; D004988:Ethers, Cyclic / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D008969:Molecular Sequence Data; D012331:RNA, Fungal / Q000235:genetics; D012337:RNA, Ribosomal, 18S / Q000235:genetics; D012988:Soil Microbiology
chemical_list: D004271:DNA, Fungal; D004146:Dioxanes; D004988:Ethers, Cyclic; D012331:RNA, Fungal; D012337:RNA, Ribosomal, 18S; C025223:1,4-dioxane