Rosai-Dorfman disease recurrence with bilateral orbital masses following immunosuppressant therapy.
Rosai-Dorfman disease is a rare condition characterised by massive lymphadenopathy involving the orbit in 11% of cases. Immunohistochemical analysis remains key to the diagnosis with characteristic immunohistochemical S100 staining of histiocytes and lymphocyte phagocytosis. We report the case of a 43-year-old female with recurrence of bilateral orbital Rosai-Dorfman disease following long-term immunosuppressant therapy. Long-term follow-up is advised in conservatively managed patients and surgery may offer more definitive treatment.
de Silva
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Craniofacial Oculoplastics Service, Chelsea and Westminster Hospital, London, UK. drdjdesilva@yahoo.co.uk
Joshi
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D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis / Q000188:drug therapy*; D001707:Biopsy, Needle; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D015618:Histiocytosis, Sinus / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D009916:Orbital Diseases / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery*; D011239:Prednisolone / Q000009:adverse effects* / Q000627:therapeutic use; D012008:Recurrence; D018570:Risk Assessment; D013997:Time Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D011239:Prednisolone