title: Finding optimal vaccination strategies for pandemic influenza using genetic algorithms.
abstract: In the event of pandemic influenza, only limited supplies of vaccine may be available. We use stochastic epidemic simulations, genetic algorithms (GA), and random mutation hill climbing (RMHC) to find optimal vaccine distributions to minimize the number of illnesses or deaths in the population, given limited quantities of vaccine. Due to the non-linearity, complexity and stochasticity of the epidemic process, it is not possible to solve for optimal vaccine distributions mathematically. However, we use GA and RMHC to find near optimal vaccine distributions. We model an influenza pandemic that has age-specific illness attack rates similar to the Asian pandemic in 1957-1958 caused by influenza A(H2N2), as well as a distribution similar to the Hong Kong pandemic in 1968-1969 caused by influenza A(H3N2). We find the optimal vaccine distributions given that the number of doses is limited over the range of 10-90% of the population. While GA and RMHC work well in finding optimal vaccine distributions, GA is significantly more efficient than RMHC. We show that the optimal vaccine distribution found by GA and RMHC is up to 84% more effective than random mass vaccination in the mid range of vaccine availability. GA is generalizable to the optimization of stochastic model parameters for other infectious diseases and population structures.
authors.affiliation: Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA.
authors.forename: Rajan
authors.initials: R
authors.lastname: Patel
authors.forename: Ira M
authors.initials: IM
authors.lastname: Longini
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Halloran
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000465:Algorithms; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D015276:Health Care Rationing / Q000379:methods; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009980:Influenza A virus; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D032541:Mass Vaccination / Q000458:organization & administration; D008875:Middle Aged; D008954:Models, Biological; D013269:Stochastic Processes
chemical_list: D007252:Influenza Vaccines