Formation of core/shell nanoparticles with a lipid core and their application as a drug delivery system.
A novel preparation method for core/shell nanoparticles with a drug-loaded lipid core was designed and characterized. The lipid core is composed of lecithin and a drug, and the polymeric shell is composed of Pluronics (poly(ethylene oxide)-poly (propylene oxide)-poly(ethylene oxide) triblock copolymer, F-127). For the formation of stabilized core/shell nanoparticles, freeze-drying was performed in the presence of trehalose used as a cryoprotectant. Cryogenic transmittance electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and a particle size analyzer were used to observe the formation of the stabilized core/shell nanoparticles. For the application of the core/shell nanoparticles as a drug carrier, paclitaxel, a potent anticancer drug, was loaded into the core/shell nanoparticles, and the drug loading amount and the drug release pattern were observed.
Oh
Keun Sang
KS
Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Ku, Taejeon, Korea 306-791.
Lee
Kyung Eun
KE
Han
Sung Sik
SS
Cho
Sun Hang
SH
Kim
Dongmin
D
Yuk
Soon Hong
SH
D002152:Calorimetry, Differential Scanning; D020285:Cryoelectron Microscopy; D004337:Drug Carriers; D004339:Drug Compounding; D005612:Freeze Drying; D008055:Lipids; D049329:Nanostructures; D017239:Paclitaxel / Q000008:administration & dosage; D010713:Phosphatidylcholines; D020442:Poloxamer
D004337:Drug Carriers; D008055:Lipids; D010713:Phosphatidylcholines; D020442:Poloxamer; D017239:Paclitaxel