title: A solitary laryngeal neurofibroma ina pediatric patient.
abstract: A neurofibroma of the larynx is a rare disease that usually involves the arytenoids and the aryepiglottic fold. Pediatric patients with a laryngeal neurofibroma often present with progressive dyspnea. A definitive diagnosis of a laryngeal neurofibroma is based on the histopathologic demonstration of the characteristic spindle cells, and a positive result in immunohistochemical staining for S-100 protein. Tumor excision of laryngeal neurofibromas by an external approach was formerly common. We present a case of a solitary laryngeal neurofibroma in a 4-year-old child that was completely excised using direct laryngoscopy and a CO2 laser. There has been no recurrence after a follow-up of 4 years. For pediatric patients with an isolated laryngeal neurofibroma, endoscopic surgery provides an alternative approach due to its safety, effectiveness, and minimal invasiveness.
authors.affiliation: Department of Otolaryngology, Chang Gung Memorial Hospital, Taipei.
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Chen
authors.forename: Tuan-Jen
authors.initials: TJ
authors.lastname: Fang
authors.forename: Hsueh-Yu
authors.initials: HY
authors.lastname: Li
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D007828:Laryngoscopy; D007830:Larynx / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D009455:Neurofibroma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis
chemical_list: D009418:S100 Proteins