title: Asymmetric direct aldol reaction catalyzed by an L-prolinamide derivative: considerable improvement of the catalytic efficiency in the ionic liquid.
abstract: The asymmetric direct aldol reactions of a wide scope of aldehydes with unmodified ketones in the presence of 20 mol%(S,S,S)-pyrrolidine-2-carboxylic acid (2'-hydroxyl-1',2'-diphenyl-ethyl)-amine (1) were performed in ionic liquids; aldol products with 91 to >99% ees for aromatic aldehydes and 99% ees for alphatic aldehydes were offered by the present procedure.
authors.affiliation: Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Guo
authors.forename: Lin-Feng
authors.initials: LF
authors.lastname: Cun
authors.forename: Liu-Zhu
authors.initials: LZ
authors.lastname: Gong
authors.forename: Ai-Qiao
authors.initials: AQ
authors.lastname: Mi
authors.forename: Yao-Zhong
authors.initials: YZ
authors.lastname: Jiang