title: Functional imaging of a large demyelinating lesion.
abstract: OBJECTIVE
  To determine the metabolic characterization of a large solitary demyelinating lesion.
  
  
  METHODS
  Magnetic Resonance Spectroscopy (MRS) and Positron Emission Tomography (PET) studies with 2-deoxy-2-[F-18]fluoro-d-glucose (FDG), carbon-11-methionine (methionine) and carbon-11-choline (choline) were done on the demyelinating lesion.
  
  
  RESULTS
  The demyelinating lesion exhibited a low glucose uptake, prominent methionine uptake and a minimal choline uptake on the PET studies. MRS data revealed an increased choline to creatine (cho/cr) ratio and a decreased N-acetyl-aspartate to creatine (NAA/cr) ratio, which demonstrated a return to near normal ratios on follow-up study.
  
  
  CONCLUSIONS
  The report summarizes the metabolic characteristics of a demyelinating plaque.
authors.affiliation: Wallace-Kettering Neurosciences Institute, Wright State University, Kettering Medical Center, 45429 OH., USA. vasanthapadma123@rediffmail.com
authors.forename: M V
authors.initials: MV
authors.lastname: Padma
authors.forename: M
authors.initials: M
authors.lastname: Adineh
authors.forename: K
authors.initials: K
authors.lastname: Pugar
authors.forename: J
authors.initials: J
authors.lastname: Mukherjee
authors.forename: M
authors.initials: M
authors.lastname: Satter
authors.forename: B
authors.initials: B
authors.lastname: Shi
authors.forename: K
authors.initials: K
authors.lastname: Dunigan
authors.forename: K
authors.initials: K
authors.lastname: Bidwell
authors.forename: B
authors.initials: B
authors.lastname: Ezzeddine
authors.forename: J
authors.initials: J
authors.lastname: Mantil
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology; D003711:Demyelinating Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008715:Methionine; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D049268:Positron-Emission Tomography; D011859:Radiography
chemical_list: D019788:Fluorodeoxyglucose F18; C086242:carbon-11 methionine; D008715:Methionine