title: Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins.
abstract: L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.
authors.affiliation: Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, 33006, Oviedo, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Pérez
authors.forename: Felipe
authors.initials: F
authors.lastname: Lombó
authors.forename: Lili
authors.initials: L
authors.lastname: Zhu
authors.forename: Miranda
authors.initials: M
authors.lastname: Gibson
authors.forename: Alfredo F
authors.initials: AF
authors.lastname: Braña
authors.forename: Jurgen
authors.initials: J
authors.lastname: Rohr
authors.forename: José A
authors.initials: JA
authors.lastname: Salas
authors.forename: Carmen
authors.initials: C
authors.lastname: Méndez
mesh_terms: D003001:Cloning, Molecular; D004798:Enzymes / Q000235:genetics; D006601:Hexoses / Q000096:biosynthesis* / Q000235:genetics*; D015394:Molecular Structure; D009279:Naphthacenes / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology; D010957:Plasmids / Q000235:genetics / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D004798:Enzymes; D006601:Hexoses; D009279:Naphthacenes; C080889:5838 DNI; C006487:amicetose