The salt paradox and its possible implications in managing hypertensive diabetic patients.
Diabetes mellitus is one of the leading causes of end-stage renal disease. The pathogenesis of diabetic nephropathy is still poorly understood, but glomerular injury has been ascribed, at least in part, to glomerular hyperfiltration, which occurs early in the course of diabetes mellitus. Therefore, a better understanding of the early dysfunctions observed in the diabetic kidney may permit the development of new strategies to prevent diabetic nephropathy. In this review, we discuss the pathophysiology for the paradoxical relationship between dietary salt and glomerular filtration rate observed in early diabetes mellitus and possible implications in managing diabetic patients.
Vallon
Volker
V
Department of Medicine, University of California San Diego & VASDHS, 3350 La Jolla Village Drive (9151), San Diego, CA 92161, USA. vvallon@ucsd.edu
Blantz
Roland
R
Thomson
Scott
S
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003928:Diabetic Nephropathies / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control*; D004039:Diet, Sodium-Restricted; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism; D012982:Sodium, Dietary / Q000009:adverse effects* / Q000493:pharmacokinetics
D012982:Sodium, Dietary