[Power law equation and liberation kinetics].
For the modelling of the kinetics of diffusion and relaxation in the polymer matrix, the power law equation in a two-parameter or three-parameter form is employed. The introductory part of the paper summarizes the employed varieties of the power law equation including the equation making it possible to distinguish diffusion from relaxation. The liberation kinetics of pilocarpinium chloride from lyophilized lamellae with graded amounts of hydroxypropylmethylcellulose is expressed by power law equations and their parameters are compared. The conclusion discusses the usability of the power law equation in the modelling of liberation of active ingredients and recommends the use of the three-parameter power law equation with a shift of the liberation out of the origin of the coordinates.
Zatloukal
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Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové. zsz@faf.cuni.cz
D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D005612:Freeze Drying; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives*; D010862:Pilocarpine / Q000493:pharmacokinetics*; D013607:Tablets
D013607:Tablets; D010862:Pilocarpine; D065347:Hypromellose Derivatives; D008747:Methylcellulose