Labelling of manganese-based magnetic resonance imaging (MRI) contrast agents with the positron emitter 51Mn, as exemplified by manganese-tetraphenyl-porphin-sulfonate (MnTPPS4).
The potential tumor seeking MRI contrast agent MnTPPS(4) was labelled with the positron emitting nuclide (51)Mn in no-carrier-added (n.c.a.) form. The complex formation kinetics were investigated and the apparent rate constants were determined under pseudo-first-order conditions. The derived bimolecular rate constants gave the Arrhenius parameters E(A)=84 kJ mol(-1) and A=2 x 10(12)s(-1)M(-1). Optimum labelling conditions were derived (radiochemical yields >99% possible, effective yields about 32%). Separation and purification of n.c.a. (51)MnTPPS(4) were performed for potential human use. All impurities were <1%.
Klein
A T J
AT
Institut für Nuklearchemie, Forschungszentrum Jülich GmbH, D-52425 Jülich, Germany.
Rösch
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Coenen
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Qaim
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D003287:Contrast Media / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis; D011166:Porphyrins / Q000737:chemistry* / Q000302:isolation & purification
D003287:Contrast Media; D011166:Porphyrins; C016136:tetraphenylporphine sulfonate; D008345:Manganese