title: Radiopaque coil insertion into breast cancers prior to neoadjuvant chemotherapy.
abstract: Between May 1998 and December 2002, neoadjuvant chemotherapy was given to 81 women aiming to reduce tumour size and avoid mastectomy. A coil was inserted under ultrasound guidance into the tumour before treatment started. The impact of coil placement on subsequent surgery was assessed prospectively. Clinical response was seen in 69 patients and breast conservation was achieved in 60 cases. In 19 cases (23%) mammography and ultrasound were normal and localization was achieved exclusively by use of the coil. Eight of these 19 (10% of the total) had a complete pathological response; however in the remaining 11 cases (13%) there was residual invasive cancer. This study suggests that in patients undergoing neoadjuvant chemotherapy surgery is still appropriate even when clinical response appears complete. The use of the coil identifies 13% of patients with otherwise undetectable residual disease and is a valuable guide in identifying the site for further surgery.
authors.affiliation: Department of Radiology, Maidstone Hospital Breast Unit, Royal British Legion Village, Aylesford, Maidstone, Kent ME20 7NJ, UK. sever@blueyonder.co.uk
authors.forename: Ali R
authors.initials: AR
authors.lastname: Sever
authors.forename: Mary E R
authors.initials: ME
authors.lastname: O'Brien
authors.forename: Stephen
authors.initials: S
authors.lastname: Humphreys
authors.forename: Inderjit
authors.initials: I
authors.lastname: Singh
authors.forename: Susan E
authors.initials: SE
authors.lastname: Jones
authors.forename: Peter A
authors.initials: PA
authors.lastname: Jones
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008327:Mammography / Q000295:instrumentation*; D015412:Mastectomy, Segmental; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D018365:Neoplasm, Residual / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D018084:Ultrasonography, Interventional
chemical_list: D003287:Contrast Media