title: Regional migratory osteoporosis: a review illustrated by five cases.
abstract: Regional migratory osteoporosis is an uncommon self-limiting disease characterized by an arthralgia which migrates between the weight-bearing joints of the lower limb. The radiological features of the disease obtained by conventional radiography, CT, MRI and radionuclide scintigraphy are illustrated by means of five case reports. These range from the most common presentation of sequential, proximal to distal spread in the lower limb to the rare intra-articular form, and disease involving the axial skeleton is also recognized. Clinical and radiographical features often overlap with those of diseases such as transient osteoporosis of the hip and transient bone marrow oedema syndrome, which is reflected in confusing terminology. Histological sampling is usually unnecessary; the radiological features are characteristic and the histological findings are not specific. Regional migratory osteoporosis is associated with systemic osteoporosis. This association is probably under-recognized, and has implications for the pathophysiology of the disease and for treatment.
authors.affiliation: Department of Radiology, Norfolk and Norwich University Hospital, Norwich, UK. andoni.toms@nnuh.nhs.uk
authors.forename: A P
authors.initials: AP
authors.lastname: Toms
authors.forename: T J
authors.initials: TJ
authors.lastname: Marshall
authors.forename: E
authors.initials: E
authors.lastname: Becker
authors.forename: S T
authors.initials: ST
authors.lastname: Donell
authors.forename: E M
authors.initials: EM
authors.lastname: Lobo-Mueller
authors.forename: T
authors.initials: T
authors.lastname: Barker
mesh_terms: D000328:Adult; D000842:Ankle; D001853:Bone Marrow / Q000000981:diagnostic imaging; D001855:Bone Marrow Diseases / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000000981:diagnostic imaging; D004487:Edema; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D006801:Humans; D007866:Leg; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D010388:Pelvis; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed / Q000379:methods