title: Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa.
abstract: OBJECTIVE
  Recovery from anorexia nervosa is confounded by intrusive anorectic cognitions and rituals. It has been observed that olanzapine, an atypical antipsychotic, can reduce this anorexic rumination. A pilot study was designed to test the effectiveness of olanzapine in this role.
  
  
  METHODS
  A randomized trial of olanzapine versus chlorpromazine, with anorexic rumination as the primary outcome, was conducted. Of the 26 patients who presented, 15 were randomized in a balanced block design, eight to olanzapine and seven to chlorpromazine.
  
  
  RESULTS
  Only the olanzapine group had a significant reduction in the degree of rumination.
  
  
  CONCLUSIONS
  Olanzapine may be of benefit in anorexia nervosa by causing a reduction in anorexic rumination.
authors.affiliation: Peter Beumont Eating Disorder Service, Ashfield, NSW, Australia. naresh.mondraty@wesleymission.org.au
authors.forename: Naresh
authors.initials: N
authors.lastname: Mondraty
authors.forename: C Laird
authors.initials: CL
authors.lastname: Birmingham
authors.forename: Stephen
authors.initials: S
authors.lastname: Touyz
authors.forename: Viktoria
authors.initials: V
authors.lastname: Sundakov
authors.forename: Lucy
authors.initials: L
authors.lastname: Chapman
authors.forename: Pierre
authors.initials: P
authors.lastname: Beumont
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000627:therapeutic use*; D002746:Chlorpromazine / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D000077152:Olanzapine
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine; D002746:Chlorpromazine