Future pharmacological treatment options for nonexudative and exudative age-related macular degeneration.
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the industrialised world. Within the past decade, researchers have introduced many promising prevention and treatment options in an attempt to minimise the central vision loss imparted from AMD. Based on large-scale, randomised, prospective, placebo-controlled trials, a specially formulated combination of the antioxidants vitamin C, vitamin E, beta-carotene, copper and zinc is the only proven means of AMD prophylaxis. Thermal laser photocoagulation and photodynamic therapy with verteporfin are the only standard treatment options. However, efficacy is limited and treatment is only applicable to a minority of AMD patients. Thus, alternative pharmacological interventions are in all phases of clinical development. Researchers are guardedly optimistic that these advances may change the entire approach to AMD management in the near future. This review article will detail the currently accepted treatment options, as well as describe several of the more promising investigational pharmacological approaches to AMD.
Comer
Grant M
GM
Indiana University School of Medicine, Department of Ophthalmology, 702 Rotary Circle, Indianapolis, IN 46202, USA. gcomer@iupui.edu
Ciulla
Thomas A
TA
Heier
Jeffery S
JS
Criswell
Mark H
MH
D000975:Antioxidants / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000639:trends*; D015507:Drugs, Investigational / Q000627:therapeutic use*; D006801:Humans; D008268:Macular Degeneration / Q000188:drug therapy* / Q000473:pathology; D008269:Macular Edema / Q000188:drug therapy / Q000473:pathology; D010778:Photochemotherapy / Q000639:trends*
D000975:Antioxidants; D015507:Drugs, Investigational