title: The chemokine receptor D6 limits the inflammatory response in vivo.
abstract: How the inflammatory response is initiated has been well defined but relatively little is known about how such responses are resolved. Here we show that the D6 chemokine receptor is involved in the post-inflammatory clearance of beta-chemokines from cutaneous sites. After induction of inflammation by phorbol esters, wild-type mice showed a transient inflammatory response. However, in D6-deficient mice, an excess concentration of residual chemokines caused a notable inflammatory pathology with similarities to human psoriasis. These results suggest that D6 is involved in the resolution of the cutaneous inflammatory response.
authors.affiliation: The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Jamieson
authors.forename: Donald N
authors.initials: DN
authors.lastname: Cook
authors.forename: Robert J B
authors.initials: RJ
authors.lastname: Nibbs
authors.forename: Antal
authors.initials: A
authors.lastname: Rot
authors.forename: Colin
authors.initials: C
authors.lastname: Nixon
authors.forename: Pauline
authors.initials: P
authors.lastname: McLean
authors.forename: Antonio
authors.initials: A
authors.lastname: Alcami
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Lira
authors.forename: Maria
authors.initials: M
authors.lastname: Wiekowski
authors.forename: Gerard J
authors.initials: GJ
authors.lastname: Graham
mesh_terms: D000818:Animals; D054426:Chemokine CXCL2; D018925:Chemokines / Q000276:immunology; D019742:Chemokines, CC / Q000037:antagonists & inhibitors / Q000276:immunology* / Q000378:metabolism; D003872:Dermatitis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006651:Histocytochemistry; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D007633:Keratins / Q000276:immunology; D008407:Mast Cells / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018809:Proliferating Cell Nuclear Antigen / Q000276:immunology; D011565:Psoriasis / Q000276:immunology / Q000473:pathology; D054447:Receptors, CCR10; D019707:Receptors, Chemokine / Q000172:deficiency / Q000276:immunology*; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D014841:von Willebrand Factor / Q000276:immunology; D000097628:Chemokine Receptor D6
chemical_list: D054426:Chemokine CXCL2; D018925:Chemokines; D019742:Chemokines, CC; D007633:Keratins; D018809:Proliferating Cell Nuclear Antigen; D054447:Receptors, CCR10; D019707:Receptors, Chemokine; D014841:von Willebrand Factor; D000097628:Chemokine Receptor D6; C404915:Cxcl2 protein, mouse