title: Model-based segmentation of medical imagery by matching distributions.
abstract: The segmentation of deformable objects from three-dimensional (3-D) images is an important and challenging problem, especially in the context of medical imagery. We present a new segmentation algorithm based on matching probability distributions of photometric variables that incorporates learned shape and appearance models for the objects of interest. The main innovation over similar approaches is that there is no need to compute a pixelwise correspondence between the model and the image. This allows for a fast, principled algorithm. We present promising results on difficult imagery for 3-D computed tomography images of the male pelvis for the purpose of image-guided radiotherapy of the prostate.
authors.affiliation: Department of Computer Science, Rensselaer Polytechnic Institute, Troy, NY 12180, USA. freedman@cs.rpi.edu
authors.forename: Daniel
authors.initials: D
authors.lastname: Freedman
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Radke
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Yongwon
authors.initials: Y
authors.lastname: Jeong
authors.forename: D Michael
authors.initials: DM
authors.lastname: Lovelock
authors.forename: George T Y
authors.initials: GT
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods; D008297:Male; D008954:Models, Biological; D015233:Models, Statistical; D010363:Pattern Recognition, Automated / Q000379:methods*; D025341:Principal Component Analysis; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016008:Statistical Distributions; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods