title: [Cardiac hypertrophy and calcium signaling].
abstract: Numerous studies have implicated intracellular Ca(2+) as a signal for cardiac hypertrophy. It has recently been reported that the calcium-dependent phosphatase calcineurin plays a critical role in the development of cardiac hypertrophy. It is also reported that cyclosporin A and FK506, calcineurin inhibitors, inhibit the development of cardiac hypertrophy. Inhibiting the calcineurin activity may be of potential benefit for prevention of cardiac hypertrophy and heart failure.
authors.affiliation: Department of Medicine III, Chiba University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Asakawa
authors.forename: I
authors.initials: I
authors.lastname: Komuro