title: [Acute chest syndrom in a patient with homozygous sickle cell anemia].
abstract: The Acute Chest Syndrome (ACS) is defined by the association of chest pain with dyspnea, fever, a recent radiological abnormality and hyperleucocytosis. Acute pulmonary complications are the primary cause of mortality in sickle cell patients. We report a 19-year old male patient with homozygous sickle cell anemia who consults for respiratory symptomatology and bone algia. The diagnosis of ACS by left pneumopathy due to pneumococcal infection was based on the clinical tests, chest x-ray and blood culture. The appearance of pneumopathy in patients suffering from sickle cell anemia is explained by the functional asplenia and the inability of phagocyte cells to destruct bacteria. These incidents are triggered by alveolar hypoventilation, fat embolism from bone infarction, infections, pulmonary oedema and thrombosis. The evolution of these ACS by pneumopathy depends on their early diagnosis and treatment but also on the sensitivity of the germs to antibiotics.
authors.forename: M
authors.initials: M
authors.lastname: Ndiaye
authors.forename: A A
authors.initials: AA
authors.lastname: Hane
authors.forename: M
authors.initials: M
authors.lastname: Ndir
authors.forename: O
authors.initials: O
authors.lastname: Ba
authors.forename: S
authors.initials: S
authors.lastname: Cissokho
authors.forename: D
authors.initials: D
authors.lastname: Diop-Dia
authors.forename: M
authors.initials: M
authors.lastname: Kandji
authors.forename: S
authors.initials: S
authors.lastname: Ndiaye
authors.forename: N O
authors.initials: NO
authors.lastname: Toure
authors.forename: A
authors.initials: A
authors.lastname: Diatta
authors.forename: A
authors.initials: A
authors.lastname: Niang
authors.forename: Y
authors.initials: Y
authors.lastname: Dia
mesh_terms: D000208:Acute Disease; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000235:genetics; D002637:Chest Pain / Q000209:etiology*; D006720:Homozygote; D006801:Humans; D008297:Male; D011018:Pneumonia, Pneumococcal / Q000150:complications*; D013577:Syndrome