[Calcium-sensing receptor antagonists for osteoporosis].
Calcium-sensing receptor (CaSR) plays pivotal roles in the regulation of PTH secretion by extracellular Ca. A new kind of drugs has been developed that stimulates secretion of PTH by antagonizing effects of Ca on CaSR. Because intermittent administration of PTH drastically increases especially cancellous bone mass, it is possible that CaSR antagonists that enhance endogenous PTH secretion also have a role in the treatment of osteoporosis.
Seiji
Fukumoto
F
Department of Laboratory Medicine, University of Tokyo Hospital.