Supramolecular modulation of action of polyamine on enzyme/DNA interactions.
Thread-in-hole complexation of cucurbit[6]uril (CB[6]) with spermidine and spermine either enhances or reduces the activity of the polyamine on the enzymatic reactions of DNA.
Isobe
Hiroyuki
H
Department of Chemistry, The University of Tokyo, Hongo, Tokyo, 113-0033, Japan.
Sato
Sota
S
Lee
Jae Wook
JW
Kim
Hee-Joon
HJ
Kim
Kimoon
K
Nakamura
Eiichi
E
D015317:Biogenic Polyamines / Q000737:chemistry* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D004798:Enzymes / Q000737:chemistry* / Q000187:drug effects; D007093:Imidazoles / Q000737:chemistry; D015394:Molecular Structure; D013095:Spermidine / Q000737:chemistry / Q000494:pharmacology; D013096:Spermine / Q000737:chemistry / Q000494:pharmacology; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D015317:Biogenic Polyamines; D001952:Bridged-Ring Compounds; D004247:DNA; D004798:Enzymes; D007093:Imidazoles; D013095:Spermidine; D013096:Spermine; C454805:cucurbit(6)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils