Characteristics of neuronal lipofuscin in the superior temporal gyrus in Alzheimer's disease do not differ from non-diseased controls: a comparison with disease-related changes in the superior frontal gyrus.
Neuronal lipofuscin characteristics in the superior temporal gyrus from 21 patients with Alzheimer's disease (AD) and from 18 age-matched non-diseased subjects were compared with previously reported findings from the superior frontal gyrus. A discriminant function analysis of lipofuscin characteristics in the superior temporal gyrus did not provide a significant predictive level for cases whose diagnoses were correctly classified (56.4%, P=0.63). In contrast, AD-related decrease in the number of smaller lipofuscin regions in the neurons of the frontal gyrus was confirmed, and the same analysis of lipofuscin characteristics in this region gave a significant predictive level for membership of the AD group of 86.6% (P<0.001). The findings indicate that changes in neuronal lipofuscin related to AD, which may reflect an increased rate of lipofuscin formation, show differences between neocortical regions. This study provides additional information on the distribution of neuropathological characteristics in AD.
Mountjoy
Christopher Q
CQ
St Andrew's Hospital, Northampton, UK.
Dowson
Jonathan H
JH
Harrington
Charles
C
Cairns
Mary R
MR
Wilton-Cox
Helen
H
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D002097:C-Reactive Protein / Q000378:metabolism*; D002452:Cell Count; D048429:Cell Size; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008062:Lipofuscin / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D016874:Neurofibrillary Tangles; D058225:Plaque, Amyloid; D016622:Silver Staining / Q000379:methods; D013702:Temporal Lobe / Q000473:pathology*; D000099153:Pentraxins
D002097:C-Reactive Protein; D008062:Lipofuscin; D009419:Nerve Tissue Proteins; D000099153:Pentraxins