title: Modification of continuous venovenous hemodiafiltration with single-pass albumin dialysate allows for removal of serum bilirubin.
abstract: A 53-year-old woman was admitted to the hospital with ischemic colitis and underwent a subtotal colectomy. She developed acute renal failure, severe hyperbilirubinemia, and intense pruritus resistant to medical treatment. Extracorporeal albumin dialysis using a Molecular Adsorbent Recirculating System (MARS; Gambro Co, Lund, Sweden) has been used to treat liver failure and reduce total serum bilirubin (SB) levels. A trial of extracorporeal albumin dialysis with continuous renal replacement therapy (RRT) was instituted to achieve net removal of SB. A 25% albumin solution was mixed with conventional dialysate to yield a dialysate concentration of 1.85% or 5.0% albumin. The patient underwent 2 continuous RRT sessions using extracorporeal albumin dialysis (1.85% and 5.0% albumin dialysate). Pretreatment and posttreatment SB levels were determined, and total bilirubin concentration (TB) also was measured in each of the collection bags during conventional and albumin dialysis. Pretreatment and posttreatment SB levels were 50.4 mg/dL (862 micromol/L) and 39.0 mg/dL (667 micromol/L) with 1.85% albumin dialysate and 47.1 mg/dL (805 micromol/L) and 39.7 mg/dL (679 micromol/L) with 5.0% albumin dialysate, respectively. The collected dialysate TB level was 0.3 mg/dL (5 micromol/L) during nonalbumin RRT and increased to 1.37 +/- 0.06 mg/dL (23 +/- 1 micromol/L) with 1.85% albumin dialysis. The collected dialysate fluid TB level was 0.3 mg/dL (5 micromol/L) during the nonalbumin RRT and increased to 1.38 +/- 0.15 mg/dL (24 +/- 3 micromol/L) during 5.0% albumin RRT. Single-pass albumin dialysis with continuous RRT cleared SB better than standard continuous RRT. Single-pass albumin dialysis with continuous RRT is feasible and may be a viable alternative in centers that do not have access to MARS therapy. This modality merits additional evaluation for its efficacy in clearing albumin-bound serum toxins.
authors.affiliation: Department of Medicine, Division of Renal Diseases and Hypertension, The George Washington University Medical Center, Washington, DC 20037, USA. lchawla@mfa.gwu.edu
authors.forename: Lakhmir S
authors.initials: LS
authors.lastname: Chawla
authors.forename: Florin
authors.initials: F
authors.lastname: Georgescu
authors.forename: Bruce
authors.initials: B
authors.lastname: Abell
authors.forename: Michael G
authors.initials: MG
authors.lastname: Seneff
authors.forename: Paul L
authors.initials: PL
authors.lastname: Kimmel
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy*; D000327:Adsorption; D000418:Albumins / Q000737:chemistry; D002780:Cholestasis, Intrahepatic / Q000150:complications; D003082:Colectomy / Q000379:methods; D017091:Colitis, Ischemic / Q000601:surgery; D005260:Female; D015312:Hemodialysis Solutions; D006440:Hemofiltration / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood / Q000209:etiology / Q000628:therapy*; D017093:Liver Failure / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy*; D011537:Pruritus / Q000209:etiology / Q000628:therapy*; D012074:Remission Induction; D006435:Renal Dialysis; D016060:Sorption Detoxification / Q000379:methods*
chemical_list: D000418:Albumins; D015312:Hemodialysis Solutions