title: Antibodies to HLA class II antigens as a risk factor for acute rejection of the allogeneic kindey.
abstract: We have investigated the association between the presence of antibodies to HLA class II antigens and the development of acute and chronic rejection after kidney transplantation. Sera from seventy-one patients before, shortly (2 weeks), and in the period between 8 and 22 months after transplantation were analyzed by the standard complement-dependent cytotoxicity (CDC) test, ELISA-LATM, and LAT tests. Absence of antibodies to HLA class II antigens before and shortly after transplantation was associated with a lower incidence of rejection episodes in the first post-transplant year. Donor-specific class II antibodies could not be detected by the ELISA-LAT test and there was no statistically significant difference in serum creatinine levels between the antibody-positive and antibody-negative patient groups two years after transplantation. Our study suggests that anti-HLA class II antibodies represent a risk factor for the development of acute immunological complications during the first year after transplantation.
authors.affiliation: Department of Immunogenetics, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. tosl@medicon.cz
authors.forename: Antonij
authors.initials: A
authors.lastname: Slavcev
authors.forename: Jiri
authors.initials: J
authors.lastname: Lacha
authors.forename: Helena
authors.initials: H
authors.lastname: Sajdlova
authors.forename: Stefan
authors.initials: S
authors.lastname: Vitko
authors.forename: Sarka
authors.initials: S
authors.lastname: Valhova
authors.forename: Ilja
authors.initials: I
authors.lastname: Striz
authors.forename: Eva
authors.initials: E
authors.lastname: Ivaskova
mesh_terms: D000208:Acute Disease; D000328:Adult; D000906:Antibodies / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology / Q000209:etiology*; D006085:Graft Survival; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D016019:Survival Analysis; D014184:Transplantation, Homologous
chemical_list: D000906:Antibodies; D000949:Histocompatibility Antigens Class II