title: Cytokeratin expression pattern in congenital and acquired pediatric cholesteatoma.
abstract: Pediatric cholesteatoma can be classified as congenital or acquired based on clinical criteria. We studied the expression patterns of five distinctive cytokeratins in both types of cholesteatoma in order to improve understanding of their pathogenesis and origin. A comparable expression pattern for CK10, CK14, CK18, CK19 and 34betaE12 antigens was found in the matrix of congenital and acquired pediatric cholesteatoma. Our results demonstrate that congenital and acquired pediatric cholesteatoma exhibit an identical cytokeratin distribution pattern, suggesting that they share a common origin. Therefore, it seems possible that a portion of the so-called "acquired" cholesteatoma may actually originate from advanced congenital cholesteatoma with secondary destruction of the tympanic membrane in the pediatric patient population.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, St. Elisabeth Hospital, University of Bochum, Bleichstrasse 15, 44787, Bochum, Germany.
authors.forename: Ewa
authors.initials: E
authors.lastname: Olszewska
authors.forename: Jürgen
authors.initials: J
authors.lastname: Lautermann
authors.forename: Can
authors.initials: C
authors.lastname: Koc
authors.forename: Matthias
authors.initials: M
authors.lastname: Schwaab
authors.forename: Stefan
authors.initials: S
authors.lastname: Dazert
authors.forename: Henning
authors.initials: H
authors.lastname: Hildmann
authors.forename: Holger
authors.initials: H
authors.lastname: Sudhoff
mesh_terms: D002648:Child; D002675:Child, Preschool; D018424:Cholesteatoma, Middle Ear / Q000145:classification / Q000151:congenital / Q000209:etiology* / Q000378:metabolism*; D004432:Ear, Middle / Q000378:metabolism*; D004817:Epidermis / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism*; D008297:Male; D009092:Mucous Membrane / Q000378:metabolism
chemical_list: D007633:Keratins