[Association study between benign prostatic hyperplasia and primary hypertension].
OBJECTIVE
To assess whether primary hypertension affects the occurrence and progression of benign prostatic hyperplasia (BPH).


METHODS
A total of 423 cases of BPH, undergoing transurethral resection of prostate (TURP) or open surgery due to severe low urinary tract symptoms, were reviewed and analyzed. All cases were verified to be BPH postoperatively following histopathological examination.


RESULTS
Of 423 patients, 295 cases (69.7%) were simple BPH (group BPH-NT); 128 cases (30.3%) were BPH with hypertension (group BPH-HT). The mean age and the incidence of haematuria were significantly higher in group BPH-HT than those in group BPH-NT (P < 0.05). The time of BPH occurrence and surgical treatment in group BPH-HT with mean diastolic blood pressure >/= 90 mmHg was significantly earlier than those with diastolic blood pressure < 90 mmHg (P < 0.05; P < 0.01). As compared with group BPH-NT, the time of BPH occurrence was significantly earlier in group BPH-HT with more than 10 years hypertension; the rate of urinary retention and haematuria was significantly higher and prostatic volume was significantly greater in group BPH-HT with more than 20 years hypertension; (all P < 0.05). Additionally, prostatic volume was positively correlated with the years of hypertension in group BPH-HT (Rsq = 0.056, P = 0.009).


CONCLUSIONS
The present results demonstrate that BPH may be frequently accompanied by the disease of hypertension. A long-term hypertension, particularly the condition of high diastolic blood pressure may improve the occurrence and clinical progression of BPH.
Guo
Li-jun
LJ
Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, Beijing 100034, China.
Zhang
Xiang-hua
XH
Li
Pei-jun
PJ
Na
Yan-qun
YQ
D000368:Aged; D000369:Aged, 80 and over; D006417:Hematuria / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000473:pathology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016055:Urinary Retention / Q000209:etiology