[The effects of sex and age on DNA adduct formation in human lung tissue].
In order to evaluate the roles of sex and age in the formation of lung tissue DNA adducts, the levels of DNA adducts in human lung tissues from both patients with or without lung cancer were examined. The results showed there was a low correlation coefficient (r=0.11) between age and DNA adducts, but a significant difference in sex being observed. Smoking is a strong factor in the formation of DNA adducts. However, the role of endocrine can not be ruled out.
Yang
K
K
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Cui
T
T
Lü
J
J
Meng
Q
Q
Zhang
H Q
HQ
Zhao
Z W
ZW
Xie
H W
HW
He
X W
XW
D000367:Age Factors; D000368:Aged; D018736:DNA Adducts / Q000235:genetics* / Q000302:isolation & purification; D004249:DNA Damage / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects*
D018736:DNA Adducts; D004273:DNA, Neoplasm