New fACEs to the renin-angiotensin system.
Inhibition of the angiotensin-converting enzyme (ACE) protects against the progression of several cardiovascular diseases. Recent evidence suggests that some of the beneficial effects of ACE inhibitors can be attributed to the activation of a distinct ACE signaling cascade rather than to the changes in angiotensin II and bradykinin levels. Moreover, at least one other ACE homolog (ACE2) plays a significant role in the regulation of heart and kidney function.
Fleming
Ingrid
I
Vascular Signaling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany. fleming@em.uni-frankfurt.de
Kohlstedt
Karin
K
Busse
Rudi
R
D000595:Amino Acid Sequence; D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology*
D007703:Peptidyl-Dipeptidase A