title: Bifunctional organocatalysts for enantioselective aza-Morita-Baylis-Hillman reaction.
abstract: The efficient and novel bifunctional organocatalyst for the enantioselective aza-Morita-Baylis-Hillman (aza-MBH) reaction has been established with (S)-3-(N-isopropyl-N-3-pyridinylaminomethyl)BINOL for the first time. The reaction proved to be deeply influenced by the position of the Lewis base attached to BINOL. The acid-base-mediated functionalities for the activation of the substrate and the fixing of conformation of the organocatalyst are harmoniously performed to promote the reaction with high enantiocontrol.
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Matsui
authors.forename: Shinobu
authors.initials: S
authors.lastname: Takizawa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sasai