Hedgehog signaling: an Arrestin connection?
Arrestins are best known for terminating signaling by G protein coupled receptors. New binding, localization and genetic studies suggest that Arrestins may also participate in the transduction of Hedgehog signals by the seven transmembrane domain protein, Smoothened.
Kalderon
Daniel
D
Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York NY 10027, USA. ddk1@columbia.edu
D000818:Animals; D019390:Arrestins / Q000235:genetics / Q000378:metabolism; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology; D051157:Frizzled Receptors; D053823:Hedgehog Proteins; D008565:Membrane Proteins / Q000378:metabolism; D010766:Phosphorylation; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D000072086:Smoothened Receptor
D019390:Arrestins; D029721:Drosophila Proteins; D051157:Frizzled Receptors; C058784:fz protein, Drosophila; D053823:Hedgehog Proteins; C077245:hh protein, Drosophila; D008565:Membrane Proteins; D043562:Receptors, G-Protein-Coupled; C100664:smo protein, Drosophila; D000072086:Smoothened Receptor