title: Synthesis and in vitro pharmacological activity of oxypropanol analogs of labetalol.
abstract: New oxypropanol alpha- and beta-adrenoceptor blocking agents, analogs of labetalol, were synthesised and studied in vitro in left atria and aorta for alpha and beta activity.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Aldo Moro 6, 53100 Siena, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Brizzi
authors.forename: Vittorio
authors.initials: V
authors.lastname: Brizzi
authors.forename: Massimo
authors.initials: M
authors.lastname: Valoti
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects; D006325:Heart Atria / Q000187:drug effects; D007741:Labetalol / Q000138:chemical synthesis* / Q000494:pharmacology; D020005:Propanols / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D020005:Propanols; D007741:Labetalol