title: [Clinicopathologic features and treatment outcomes of primary hepatic lymphoma: a report of four cases].
abstract: OBJECTIVE
  Primary hepatic lymphoma (PHL), a rare malignancy, has seldom been reported. This article was to investigate clinicopathologic features and treatment of PHL.
  
  
  METHODS
  Data of 4 patients with PHL, treated in Cancer Center, Sun Yat-sen University from Nov. 1994 to May 2004, were retrospectively analyzed.
  
  
  RESULTS
  Of the 4 patients, 3 were men, and 1 was woman, with a median age of 53 years old; 3 had single focus, and 1 had multi-foci. All patents were positive for HBV antigen, 3 were misdiagnosed preoperatively, and 1 had no clear diagnosis before operation. Pathologic examination revealed that 3 were B-cell non-Hodgkin's lymphoma, and 1 was Hodgkin's lymphoma. Two patients received resection, and 2 received biopsy; all patients received adjuvant chemotherapy postoperatively.
  
  
  CONCLUSIONS
  HBV infection might relate with the development of PHL. PHL should be considered for the patients presented liver mass and B-symptomatolgy. Resection followed by adjuvant chemotherapy with CHOP regiment seems to be the best option for PHL.
authors.affiliation: Department of Hepatobiliary Tumor, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China.
authors.forename: Yao-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Min-Shan
authors.initials: MS
authors.lastname: Chen
authors.forename: Hui-Hong
authors.initials: HH
authors.lastname: Liang
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Ya-Qi
authors.initials: YQ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003951:Diagnostic Errors; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D018963:Hepatitis Antigens / Q000032:analysis; D006689:Hodgkin Disease / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000628:therapy*; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D012189:Retrospective Studies; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D018963:Hepatitis Antigens; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone