A single session of resistance exercise enhances insulin sensitivity for at least 24 h in healthy men.
The aim of the present study was to determine whether a single session of resistance exercise improves whole-body insulin sensitivity in healthy men for up to 24 h. Twelve male subjects (23 +/- 1 years) were studied over a period of 4 days during which they consumed a standardized diet, providing 0.16 +/- 0.01 MJ.kg(-1).day(-1) containing 15 +/- 0.1 energy% (En%) protein, 29 +/ -0.1 En% fat and 55 +/- 0.3 En% carbohydrate. Insulin sensitivity was determined 24 h before and 24 h after a single resistance exercise session (8 sets of 10 repetitions at 75% of 1 repetition maximum for two leg exercise tasks) using an intravenous insulin tolerance test. Insulin sensitivity index was calculated by the decline in arterial blood glucose concentration following intravenous administration of a single bolus of human insulin (0.075 IU.kg(-1) fat free mass). Basal glucose and insulin concentrations were not changed up to 24 h after the resistance exercise. However, a substantial 13+/-5% improvement in whole-body insulin sensitivity was observed, 24 h after the resistance exercise (P < 0.05). This study shows that even a single session of resistance exercise improves whole-body insulin sensitivity for up to 24 h in healthy men, which is consistent with earlier observations following endurance exercise tasks.
Koopman
René
R
Department of Human Biology, Maastricht University, The Netherlands. R.Koopman@HB.unimaas.nl
Manders
Ralph J F
RJ
Zorenc
Antoine H G
AH
Hul
Gabby B J
GB
Kuipers
Harm
H
Keizer
Hans A
HA
van Loon
Luc J C
LJ
D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D015444:Exercise / Q000502:physiology*; D015309:Glucose Clamp Technique; D006801:Humans; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D010807:Physical Endurance / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin