Embryo aneuploidy screening for unexplained recurrent miscarriage: a minireview.
OBJECTIVE
The aim of this study was to investigate the incidence of chromosomal abnormalities in unexplained recurrent miscarriage (RM) patients and assess the role of pre-implantation genetic diagnosis (PGD) in preventing subsequent pregnancy loss and improving pregnancy outcome.


METHODS
Pre-implantation genetic diagnosis was performed in 241 RM cycles and in 35 cycles in patients undergoing PGD for sex-linked diseases (control group). Chromosomes 13, 16, 18, 21, 22, X and Y were analysed by fluorescence in situ hybridization.


RESULTS
The implantation and pregnancy rates in RM patients were 26.4 and 36.5% versus 20.6 and 29.0% in the control group, respectively. The percentage of abnormal embryos was significantly increased in RM patients compared with controls.


CONCLUSIONS
Recurrent miscarriage is associated with a higher incidence of chromosomally abnormal embryos. In vitro fertilization (IVF) plus PGD is an important step in the management of these couples.
Rubio
Carmen
C
Instituto Valenciano de Infertilidad (IVI), University of Valencia, Spain.
Pehlivan
Tugce
T
Rodrigo
Lorena
L
Simón
Carlos
C
Remohí
Jose
J
Pellicer
Antonio
A
D000026:Abortion, Habitual / Q000175:diagnosis / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics*; D020732:Cytogenetic Analysis; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D011247:Pregnancy; D019836:Preimplantation Diagnosis