title: Effect of vitamin E supplementation on microalbuminuria, lipid peroxidation and blood prostaglandins in diabetic patients.
abstract: BACKGROUND
  Oxidative stress is an important pathogenic factor in the development of diabetic vascular complications.
  
  
  OBJECTIVE
  To study the effect of vitamin E supplementation on microalbuminuria, plasma levels of malondialdehyde (MLD) and metabolites of prostaglandins TXA2 (TXB2) and PGI2 (6-keto-PGF1alpha) and to evaluate the relation between plasma MLD and thromboxane B2 (TXB2) in diabetic patients.
  
  
  METHODS
  Diabetic microalbuminuric patients were supplemented with vitamin E 1200 IU daily (EVIT, Rodisma, Germany) and measurements of microalbuminuria, MLD, TXB2 and 6-ketoPGF1alpha were repeated after 4 months of treatment.
  
  
  RESULTS
  Vitamin E supplementation lowered microalbuminuria (93.8 +/- 45.6 vs 67.95 +/- 28.4 microg/min, p < 0.05), MLD (0.55 +/- 0.26 vs 0.32 +/- 0.16 micromol/l, p < 0.001) and also TXB2 level (115.14 +/- 22.7 vs 15.32 +/- 14.7 ng/l, p < 0.001) in diabetic microalbuminuric patients. The changes of 6-keto-PGF1alpha after treatment were not significant.
  
  
  CONCLUSIONS
  Our results did not show any significant relationship between levels of MLD and TXB2. Vitamin E supplementation significantly lowered microalbuminuria, MLD and TXB2. (Tab. 2, Fig. 2, Ref. 35).
authors.affiliation: 2nd Department of Internal Medicine, University Hospital, Faculty of Medicine, Comenius University, Bratislava, Slovakia. hirnerova@hotmail.com
authors.forename: E
authors.initials: E
authors.lastname: Hirnerova
authors.forename: B
authors.initials: B
authors.lastname: Krahulec
authors.forename: L
authors.initials: L
authors.lastname: Strbova
authors.forename: A
authors.initials: A
authors.lastname: Stecova
authors.forename: J
authors.initials: J
authors.lastname: Dekret
authors.forename: A
authors.initials: A
authors.lastname: Hajovska
authors.forename: Antwi
authors.initials: A
authors.lastname: Ch
authors.forename: A
authors.initials: A
authors.lastname: Dukat
mesh_terms: D000419:Albuminuria; D000975:Antioxidants / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000378:metabolism*; D011464:Epoprostenol / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D011453:Prostaglandins / Q000097:blood*; D013931:Thromboxanes / Q000097:blood; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D011453:Prostaglandins; D013931:Thromboxanes; D014810:Vitamin E; D008315:Malondialdehyde; D011464:Epoprostenol