Leptin effects on food and water intake in lines of chickens selected for high or low body weight.
There is an association between autonomic nervous system output and obesity. The sympathetic nervous system stimulates lipid metabolism and regulates food intake and, hence, body weight. Leptin, produced by adipocytes in proportion to their size, has been shown to directly stimulate the satiety center. In the experiment reported here, food and water intake were compared after intracerebroventricular administration of human recombinant leptin to lines of chickens that had undergone divergent selection for over 45 generations from a common White Rock base population for high (HWS) or low (LWS) body weight at 8 weeks-of-age. Leptin caused a linear decrease in food intake in chickens from the LWS line whereas no effect was observed in those from the HWS line. The HWS chickens tended to have reduced water intake post leptin administration. Others reported that leptin decreased food intake in both broiler and Leghorn chickens. Leptin concentration in the central nervous system may not contribute directly to the difference of body weight between HWS and LWS chickens.
Kuo
Alice Y
AY
Department of Animal and Poultry Sciences (0306), Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, United States.
Cline
Mark A
MA
Werner
Elizabeth
E
Siegel
Paul B
PB
Denbow
D Michael
DM
D000818:Animals; D001835:Body Weight / Q000187:drug effects* / Q000235:genetics; D001921:Brain / Q000187:drug effects; D002645:Chickens / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D006801:Humans; D007276:Injections, Intraventricular; D020738:Leptin / Q000494:pharmacology*; D008297:Male; D011956:Receptors, Cell Surface / Q000187:drug effects; D054411:Receptors, Leptin; D011994:Recombinant Proteins / Q000494:pharmacology; D012641:Selection, Genetic
C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D011994:Recombinant Proteins