Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis.
In mammals, 14 members of the Eph receptor tyrosine kinase family have been described so far. Here we present a not yet described member of this family denoted EphA10. We report the identification of three putative EphA10 isoforms: one soluble and two transmembrane isoforms. One of the latter isoforms lacked the sterile alpha motif commonly found in Eph receptors. The gene encoding EphA10 is located on chromosome 1p34 and expression studies show that EphA10 mRNA is mainly expressed in testis. Binding studies to ephrin ligands suggests that this receptor belongs to the EphA subclass of Eph receptors binding mainly to ephrin-A ligands.
Aasheim
Hans-Christian
HC
Department of Immunology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway. h.c.asheim@labmed.uio.no
Patzke
Sebastian
S
Hjorthaug
Hanne Sagsveen
HS
Finne
Eivind Farmen
EF
D000595:Amino Acid Sequence; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D036081:Receptors, Eph Family / Q000032:analysis / Q000737:chemistry / Q000145:classification*; D013737:Testis / Q000201:enzymology*
D036081:Receptors, Eph Family