Biomedical applications of 7Li NMR.
The biomedical applications of 7Li MRS and MRI have been progressing slowly. The interest derives primarily from the clinical use of Li to treat bipolar disorder. One area of concern is the nature of ionic transport and binding, so as to elucidate the mechanism(s) of therapeutic action and toxicity. Another is the development of a non-invasive, in vivo analytical tool to measure brain Li concentration and environment in humans, both as an adjunct to treatment and as a mechanistic probe. Here we review the most recent progress toward these goals.
Komoroski
Richard A
RA
Department of Radiology, University of Arkansas for Medical Sciences, South Central Mental Illness Research, Education, and Clinical Center (MIRECC), US Veterans Healthcare System, Little Rock, Arkansas 72114, USA. rakomoroski@uams.edu
D000818:Animals; D001698:Biomedical Engineering / Q000379:methods / Q000639:trends; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007554:Isotopes; D008094:Lithium; D016651:Lithium Carbonate; D018020:Lithium Compounds / Q000493:pharmacokinetics* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008657:Metabolic Clearance Rate; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D014018:Tissue Distribution
D007554:Isotopes; D018020:Lithium Compounds; D016651:Lithium Carbonate; D008094:Lithium