title: Clinical spectrum in hospitalized children with echovirus type 13 infection.
abstract: BACKGROUND
  The aim of this study was to investigate the clinical spectrum of echovirus type 13 (E13) infection in hospitalized children.
  
  
  METHODS
  From April to August 2002, prospective viral surveillance was performed for hospitalized patients (aged 10 days to 14 years) irrespective of their presenting symptoms and severity. Medical records of laboratory-confirmed echovirus 13 infection were reviewed.
  
  
  RESULTS
  Of the 41 patients analyzed, the median age was 3.4 years and 30% of them were less than 1 year of age. The male:female ratio was 1.6:1. The main clinical features were non-specific febrile illness (nine patients), gastroenteritis (seven), bronchitis (seven), aseptic meningitis (16) and idiopathic thrombocytopenic purpura (two). Each age group had their representative symptoms: less than 1 year of age, non-specific febrile illness; from 1 to 6 years of age, enterocolitis and bronchitis; more than 6 years of age, aseptic meningitis.
  
  
  CONCLUSIONS
  The representative symptoms of E13 infection in hospitalized patients were variable but strongly associated with age distribution. It was of interest to note that two patients developed idiopathic thrombocytopenic purpura along with the infection.
authors.affiliation: Department of Pediatrics, Kobe City General Hospital, Kobe 650-0046, Japan. ckg-kobayashi@rio.odn.ne.jp
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Haruta
authors.forename: Masaru
authors.initials: M
authors.lastname: Kubota
authors.forename: Kyoko
authors.initials: K
authors.lastname: Akiyoshi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Suga
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ito
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D029822:Enterovirus B, Human; D004769:Enterovirus Infections / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies