Do oestrogen receptors play a role in the pathogenesis of HIV-associated lipodystrophy?
Epidemiological data show an increased risk of HIV-associated lipodystrophy in women, and sex hormone abnormalities have been reported with highly active antiretroviral therapy (HAART). This study, which demonstrates that oestrogen receptor beta expression is significantly reduced in the subcutaneous adipose tissue of HIV-infected lipodystrophic patients, downregulated by HAART regimens including protease inhibitors (PI), and restored after switching from PI, opens perspectives for the investigation of selective oestrogen receptor modifiers for the management of this syndrome.
Barzon
Luisa
L
Departments of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy.
Zamboni
Mauro
M
Pacenti
Monia
M
Milan
Gabriella
G
Bosello
Ottavio
O
Federspil
Giovanni
G
Palù
Giorgio
G
Vettor
Roberto
R
D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D001824:Body Constitution / Q000502:physiology; D015536:Down-Regulation / Q000235:genetics; D047629:Estrogen Receptor beta / Q000032:analysis; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D039682:HIV-Associated Lipodystrophy Syndrome / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*
D047629:Estrogen Receptor beta; D017320:HIV Protease Inhibitors; D011960:Receptors, Estrogen