title: Acquired perforating disorder.
abstract: A 53-year-old man presented with asymptomatic, hyperkeratotic papules and hyperpigmented macules of the face and upper extremities. Treatment was initiated with topical tretinoin and intralesional glucocorticoids. Acquired perforating disorder is a disorder of keratinization that is associated with diabetes mellitus and uremia. Classic presentation involves hyperkeratotic papules with a central core, which occur most frequently on the lower extremities. Treatment includes topical tretinoin, glucocorticoids, keratolytics, systemic retinoids and glucocorticoids, and ultraviolet B phototherapy.
authors.affiliation: Ronald O. Perelman Department of Dermatology, New York University, USA.
authors.forename: Olympia
authors.initials: O
authors.lastname: Kovich
mesh_terms: D048909:Diabetes Complications / Q000150:complications; D006801:Humans; D007642:Keratosis / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014511:Uremia / Q000150:complications