The chemokine receptor D6 limits the inflammatory response in vivo.
How the inflammatory response is initiated has been well defined but relatively little is known about how such responses are resolved. Here we show that the D6 chemokine receptor is involved in the post-inflammatory clearance of beta-chemokines from cutaneous sites. After induction of inflammation by phorbol esters, wild-type mice showed a transient inflammatory response. However, in D6-deficient mice, an excess concentration of residual chemokines caused a notable inflammatory pathology with similarities to human psoriasis. These results suggest that D6 is involved in the resolution of the cutaneous inflammatory response.
Jamieson
Thomas
T
The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK.
Cook
Donald N
DN
Nibbs
Robert J B
RJ
Rot
Antal
A
Nixon
Colin
C
McLean
Pauline
P
Alcami
Antonio
A
Lira
Sergio A
SA
Wiekowski
Maria
M
Graham
Gerard J
GJ
D000818:Animals; D054426:Chemokine CXCL2; D018925:Chemokines / Q000276:immunology; D019742:Chemokines, CC / Q000037:antagonists & inhibitors / Q000276:immunology* / Q000378:metabolism; D003872:Dermatitis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006651:Histocytochemistry; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D007633:Keratins / Q000276:immunology; D008407:Mast Cells / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018809:Proliferating Cell Nuclear Antigen / Q000276:immunology; D011565:Psoriasis / Q000276:immunology / Q000473:pathology; D054447:Receptors, CCR10; D019707:Receptors, Chemokine / Q000172:deficiency / Q000276:immunology*; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D014841:von Willebrand Factor / Q000276:immunology; D000097628:Chemokine Receptor D6
D054426:Chemokine CXCL2; D018925:Chemokines; D019742:Chemokines, CC; D007633:Keratins; D018809:Proliferating Cell Nuclear Antigen; D054447:Receptors, CCR10; D019707:Receptors, Chemokine; D014841:von Willebrand Factor; D000097628:Chemokine Receptor D6; C404915:Cxcl2 protein, mouse