High pressure studies on transthyretin.
High hydrostatic pressure (HHP) is a powerful tool to study protein folding and the dynamics and structure of folding intermediates. Aggregates and amyloids, derived from partially folding intermediates at the junction between productive and off-pathway folding, have been studied as well, which promises better understanding of the protein misfolding diseases. Here is summarized the recent data we have collected with transthyretin under pressure.
Foguel
Débora
D
Instituto de Bioquímica Médica, Programa de Biologia estrutural, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-590, Brazil. foguel@bioqmed.ufrj.br
D000686:Amyloidosis / Q000378:metabolism; D006874:Hydrostatic Pressure; D011228:Prealbumin / Q000737:chemistry*; D013816:Thermodynamics
D011228:Prealbumin