title: Chondrosarcomas of the base of the skull in Ollier's disease or Maffucci's syndrome--three case reports and review of the literature.
abstract: Ollier's disease is a rare disease characterized by constitutional bone dysplasia with multiple enchondromas. The combination of haemangioma and chondromatoses is known as Maffucci's syndrome. Malignant degeneration of bone dysplasia into chondrosarcoma is a well-known complication, but a lesion of the base of the skull is exceptional. It is a slowly growing low-grade malignant tumour. Three new cases of chondrosarcoma of the base of the skull occurring in one patient with Marfucci's syndrome and two patients with Ollier's disease are reported and these cases are discussed in the light of the literature. A multidisciplinary approach, comprising surgery and radiotherapy, achieved good results.
authors.affiliation: Centre de Protonthérapie d'Orsay--Institut Curie, Orsay cedex Paris, France. noel@ipno.in2p3.fr
authors.forename: Georges
authors.initials: G
authors.lastname: Noël
authors.forename: Loïc
authors.initials: L
authors.lastname: Feuvret
authors.forename: Valentin
authors.initials: V
authors.lastname: Calugaru
authors.forename: Khalid
authors.initials: K
authors.lastname: Hadadi
authors.forename: François
authors.initials: F
authors.lastname: Baillet
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Mazeron
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Habrand
mesh_terms: D000328:Adult; D002648:Child; D002813:Chondrosarcoma / Q000175:diagnosis* / Q000532:radiotherapy; D004687:Enchondromatosis / Q000175:diagnosis* / Q000532:radiotherapy; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D011882:Radiotherapy, High-Energy; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000175:diagnosis*; D019292:Skull Base Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D013577:Syndrome; D014057:Tomography, X-Ray Computed