title: A pilot study of low-dose subcutaneous alemtuzumab therapy for patients with hemotherapy-refractory chronic lymphocytic leukemia.
abstract: Subcutaneous low-dose alemtuzumab (10 mg t.i.w. for 18 weeks) induced a 50% response rate, including 25% complete response, in 16 patients with refractory chronic lymphocytic leukemia (CLL) patients. The responses were substantial even in patients with unfavorable cytogenetics, fludarabine/rituximab refractoriness, Rai stage IV, previous infections, and age over 65 years. Subcutaneous low-dose alemtuzumab is effective in poor prognosis B-CLL, and has a particularly favourable toxicity profile.
authors.forename: Agostino
authors.initials: A
authors.lastname: Cortelezzi
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Pasquini
authors.forename: Barbara
authors.initials: B
authors.lastname: Sarina
authors.forename: Giambattista
authors.initials: G
authors.lastname: Bertani
authors.forename: Federica
authors.initials: F
authors.lastname: Grifoni
authors.forename: Mariangela
authors.initials: M
authors.lastname: Colombi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Lambertenghi Deliliers
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000074323:Alemtuzumab; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm / Q000627:therapeutic use*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy*; D008875:Middle Aged; D010865:Pilot Projects; D012074:Remission Induction / Q000379:methods; D016879:Salvage Therapy / Q000379:methods
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm; D000074323:Alemtuzumab