DNA degradation in development and programmed cell death.
Most mammalian cells have nuclei that contain DNA, which replicates during cell proliferation. DNA is destroyed by various developmental processes in mammals. It is degraded during programmed cell death that accompanies mammalian development. The nuclei of erythrocytes and eye lens fiber cells are also removed during their differentiation into mature cells. If DNA is not properly degraded in these processes, it can cause various diseases, including tissue atrophy, anemia, cataract, and autoimmune diseases, which indicates that DNA can be a pathogenic molecule. Here, I present how DNA is degraded during programmed cell death, erythroid cell differentiation, and lens cell differentiation. I discuss what might be or will be learned from understanding the molecular mechanisms of DNA degradation that occurs during mammalian development.
Nagata
Shigekazu
S
Laboratory of Genetics, Integrated Biology Laboratories, Graduate School of Frontier Biosciences, Osaka University, Japan. nagata@genetic.med.osaka-u.ac.jp
D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology*; D002454:Cell Differentiation; D004247:DNA / Q000378:metabolism*; D053938:DNA Fragmentation; D003851:Deoxyribonucleases / Q000737:chemistry / Q000378:metabolism; D004920:Erythropoiesis; D006801:Humans; D007113:Immunity, Innate; D007908:Lens, Crystalline / Q000166:cytology / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism / Q000648:ultrastructure; D008954:Models, Biological; D015398:Signal Transduction
D004247:DNA; D003851:Deoxyribonucleases; C109663:caspase-activated deoxyribonuclease