title: High pressure studies on transthyretin.
abstract: High hydrostatic pressure (HHP) is a powerful tool to study protein folding and the dynamics and structure of folding intermediates. Aggregates and amyloids, derived from partially folding intermediates at the junction between productive and off-pathway folding, have been studied as well, which promises better understanding of the protein misfolding diseases. Here is summarized the recent data we have collected with transthyretin under pressure.
authors.affiliation: Instituto de Bioquímica Médica, Programa de Biologia estrutural, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-590, Brazil. foguel@bioqmed.ufrj.br
authors.forename: Débora
authors.initials: D
authors.lastname: Foguel
mesh_terms: D000686:Amyloidosis / Q000378:metabolism; D006874:Hydrostatic Pressure; D011228:Prealbumin / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D011228:Prealbumin