Discordant response to chemotherapy between lymphadenopathy and bone lesions on gallium-67 scanning in Hodgkin's disease.
A 33-year-old woman with a diagnosis of Hodgkin's disease had a prechemotherapy whole-body Ga-67 scan to document gallium avidity of lesions and to assess response to therapy. A posttherapy scan showed a discordant response with complete resolution of lymphadenopathy and persistence of bone lesions. Radiographic evaluation of the left humerus, radius, and ulna demonstrated typical fibrous dysplasia as a cause for persistence of Ga-67 activity and shoulder activity probably representing arthropathy. She was in remission 3 years later although she fell and fractured the humerus through the bony lesion, and biopsy at the time of internal fixation confirmed fibrous dysplasia.
Bazarjani
Sadri
S
Division of Nuclear Medicine, Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada. sbazarjani@ottwawhospital.on.ca
Di Primio
Gina
G
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D002951:Citrates; D003937:Diagnosis, Differential; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000000981:diagnostic imaging*; D005708:Gallium; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D006801:Humans; D011379:Prognosis; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D016896:Treatment Outcome; D014915:Whole-Body Counting
D000970:Antineoplastic Agents; D002951:Citrates; D019275:Radiopharmaceuticals; D005708:Gallium; C103850:gallium citrate