Doxapram inhibits carotid sinus baroreceptors in rabbits.
1 To clarify the effects of doxapram on the baroreflex, we recorded carotid sinus nerve (CSN) activity in isolated and perfused carotid artery bifurcations of rabbits. 2 The CSN activity due to chemoreceptor stimulation was blocked by resection of the nerve branches from the carotid body. After the resection, the CSN activity was correlated to increase of carotid sinus (CS) pressure. 3 Administration of doxapram reduced the CSN activity originating from baroreceptors. The effect of doxapram on baroreceptors was dose dependent and reversible. 4 It is unlikely that doxapram altered CS wall mechanics because CS pressure did not change in the presence of the drug. 5 We conclude that doxapram acts on the cardiovascular system in part by inhibiting the negative feedback loop that originates in CS baroreceptors.
Osanai
S
S
First Department of Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka Higashi, Asahikawa 078-8510, Japan.
Takahashi
T
T
Nakano
H
H
Kikuchi
K
K
D000818:Animals; D002344:Carotid Body / Q000187:drug effects; D002346:Carotid Sinus / Q000187:drug effects* / Q000294:innervation; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004315:Doxapram / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion; D011311:Pressoreceptors / Q000187:drug effects*; D011817:Rabbits
D000697:Central Nervous System Stimulants; D004315:Doxapram