title: Spinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammation.
abstract: Spinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These data suggest that the central nervous systems of neonates and adults respond differently to peripheral noxious inputs, a fact that should be considered when selecting pain treatment strategies for neonate populations.
authors.affiliation: Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA. Rzhan@umaryland.edu
authors.forename: Rui-Xin
authors.initials: RX
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Lixing
authors.initials: L
authors.lastname: Lao
authors.forename: Jian-Tian
authors.initials: JT
authors.lastname: Qiao
authors.forename: M A
authors.initials: MA
authors.lastname: Ruda
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects; D015152:Blotting, Northern; D004399:Dynorphins / Q000096:biosynthesis*; D004591:Electrophoresis, Polyacrylamide Gel; D007249:Inflammation / Q000378:metabolism*; D011498:Protein Precursors / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013116:Spinal Cord / Q000378:metabolism*; D015854:Up-Regulation / Q000235:genetics
chemical_list: D011498:Protein Precursors; D012333:RNA, Messenger; C036448:pre-prodynorphin; D004399:Dynorphins