title: MRI brain volumetry in Rasmussen encephalitis: the fate of affected and "unaffected" hemispheres.
abstract: Rasmussen encephalitis (RE) is regarded as a unihemispheric disease. Serial three-dimensional MRIs of 18 patients under immunotherapy were analyzed volumetrically and planimetrically. Median volume loss was significantly higher in the affected than in the unaffected hemispheres (29.9 cm3/y vs 6.8 cm3/y). Correlation of the planimetrically and volumetrically assessed hemispheric ratios (HRs) was significant. The results support the concept of RE as a basically unilateral disease. Planimetric HR assessment is valid and time efficient.
authors.affiliation: Department of Neuropathology, University of Bonn, Bonn, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Larionov
authors.forename: R
authors.initials: R
authors.lastname: König
authors.forename: H
authors.initials: H
authors.lastname: Urbach
authors.forename: R
authors.initials: R
authors.lastname: Sassen
authors.forename: C E
authors.initials: CE
authors.lastname: Elger
authors.forename: C G
authors.initials: CG
authors.lastname: Bien
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001284:Atrophy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004660:Encephalitis / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000592:standards; D007167:Immunotherapy; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D008297:Male; D011237:Predictive Value of Tests; D012044:Regression Analysis; D015203:Reproducibility of Results; D013687:Telencephalon / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology