Neutrophil polycythemia rubra vera-1 expression in classic and atypical myeloproliferative disorders and laboratory correlates.
The current study of 153 subjects with both classic and atypical myeloproliferative disorders suggests that neutrophil polycythemia rubra vera-1 (PRV-1) over-expression is a non-specific feature of clonal myeloproliferation that displays significant correlation with leukocyte alkaline phosphatase score. These observations undermine the utility of the PRV-1 assay as a diagnostic test of additional value.
Sirhan
Shireen
S
Lasho
Terra L
TL
Elliott
Michelle A
MA
Tefferi
Ayalew
A
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000032:analysis; D004796:Clinical Enzyme Tests; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D007519:Isoantigens / Q000032:analysis* / Q000235:genetics; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000235:genetics; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000175:diagnosis*; D009504:Neutrophils / Q000737:chemistry; D012333:RNA, Messenger / Q000032:analysis; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000235:genetics
C407242:CD177 protein, human; D058851:GPI-Linked Proteins; D007519:Isoantigens; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D000469:Alkaline Phosphatase