[Evaluation of thrombotic risk in type 2 diabetes: determination of platelet factor 4 and beta thromboglobulin].
We achieved the dosage of platelet factor 4 (PF 4) and beta thromboglobulin (B-TG), two proteins stored in platelet alpha granules and released from the platelets when activated. These proteins were studied by ELISA technics in patients with type 2 diabetes without any complications (n = 32), with thrombotic complication (n = 32) and in a healthy control group (n = 32). The diabetic patients with complications had significantly elevated plasma levels of PF4 and B-TG compared with diabetic patients without complications, whereas levels of these proteins where normal in control group. These high rates of PF4 and B-TG were significantly related to a disturbance of lipidic balance. Our data suggest that platelet hyperactivation may be a reliable element in the pathogenesis of thrombotic complications in type 2 diabetes.
Diop
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S
Service d'Hématologie - UCAD BP 5002 Dakar
Ka-Cisse
M
M
Toure-Fall
A O
AO
Diagne Fall-Sarr
F
F
Diop
S N
SN
Thiam
D
D
Diakhate
L
L
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000097:blood* / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010978:Platelet Factor 4 / Q000032:analysis*; D018570:Risk Assessment; D013927:Thrombosis / Q000097:blood* / Q000209:etiology; D001620:beta-Thromboglobulin / Q000032:analysis*
D001620:beta-Thromboglobulin; D010978:Platelet Factor 4