Death begets failure in the heart.
Recently, low--but abnormal--rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.
Foo
Roger S-Y
RS
Department of Medicine, Cardiovascular Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Mani
Kartik
K
Kitsis
Richard N
RN
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002303:Cardiac Output, Low / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D006801:Humans; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology