title: Immunoenhancing effects of a new probiotic strain, Lactobacillus fermentum PL9005.
abstract: The immunoenhancing effects of Lactobacillus fermentum PL9005 were assessed via mouse intragastric inoculation. The number of immunoglobulin A-positive cells in the small intestine, CD4+ T lymphocytes in the peripheral blood, and the lymphocyte proliferation response to mitogen stimulation (lipopolysaccharide) increased in mice fed L. fermentum PL9005. The lactic acid concentration also increased dose dependently in the small intestine of mice fed L. fermentum PL9005. No differences were found in body weight, food intake, and clinical signs between mice fed L. fermentum PL9005 and the control group. Results indicated that L. fermentum PL9005 is a probiotic with immunoenhancing properties.
authors.affiliation: Department of Laboratory Animal Medicine, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Korea.
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Park
authors.forename: Yeonhee
authors.initials: Y
authors.lastname: Lee
authors.forename: Enpyo
authors.initials: E
authors.lastname: Moon
authors.forename: Seung-Hyeok
authors.initials: SH
authors.lastname: Seok
authors.forename: Sun-A
authors.initials: SA
authors.lastname: Cho
authors.forename: Min-Won
authors.initials: MW
authors.lastname: Baek
authors.forename: Hui-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Dong-Jae
authors.initials: DJ
authors.lastname: Kim
authors.forename: Jae-Hak
authors.initials: JH
authors.lastname: Park
mesh_terms: D000818:Animals; D005260:Female; D007070:Immunoglobulin A; D007421:Intestine, Small / Q000276:immunology*; D019344:Lactic Acid / Q000378:metabolism*; D007778:Lactobacillus / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D019936:Probiotics; D013047:Specific Pathogen-Free Organisms
chemical_list: D007070:Immunoglobulin A; D019344:Lactic Acid