Dietary bioflavonoids induce apoptosis in human leukemia cells.
Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.
Matsui
Jun
J
Department of Developmental Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 154-8535, Japan.
Kiyokawa
Nobutaka
N
Takenouchi
Hisami
H
Taguchi
Tomoko
T
Suzuki
Kyoko
K
Shiozawa
Yusuke
Y
Saito
Masahiro
M
Tang
Wei-Ran
WR
Katagiri
Yohko U
YU
Okita
Hajime
H
Fujimoto
Junichiro
J
D017304:Annexin A5 / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects*; D020169:Caspases / Q000378:metabolism; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D016130:Immunophenotyping; D007938:Leukemia / Q000378:metabolism / Q000473:pathology*; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D017304:Annexin A5; D005419:Flavonoids; D020169:Caspases