title: Scoring approach based on fish biomarkers applied to French river monitoring.
abstract: The aim was to apply a multimarker scoring approach as complementary to freshwater monitoring programmes carried out by the Water Agency Adour-Garonne. Fish (chub, barbel and trout) were collected in 11 sites in rivers in south-west France. Five biomarkers of response were measured either in muscle or brain for acetylcholinesterase (AChE) and in liver for glutathione S-transferase, catalase and 7-ethoxyresorufine O-deethylase. As a result of multivariate analysis, sites were clearly discriminated mainly by 7-ethoxyresorufine O-deethylase and acetylcholinesterase activities. According to the scoring approach, a multimarker pollution index was calculated for each sampling site as the sum of the response index of the five measured biomarkers (pollution index). Sorting was established by ranging the sites from lightly to highly contaminated locations.
authors.affiliation: Laboratoire de Physico-Toxicochimie des systèmes Naturels, UMR 5472 CNRS, Université Bordeaux I, F-33405 Talence, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Aarab
authors.forename: Olivier
authors.initials: O
authors.lastname: Champeau
authors.forename: Pascal
authors.initials: P
authors.lastname: Mora
authors.forename: Michèle
authors.initials: M
authors.lastname: Daubeze
authors.forename: Philippe
authors.initials: P
authors.lastname: Garrigues
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Narbonne
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D004785:Environmental Pollutants; D005399:Fishes; D005602:France; D005982:Glutathione Transferase / Q000378:metabolism; D015233:Models, Statistical; D015999:Multivariate Analysis; D009132:Muscles / Q000378:metabolism; D045483:Rivers; D013347:Subcellular Fractions
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D002374:Catalase; D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; D000110:Acetylcholinesterase