[Advances in gene expression of bone marrow stromal cells].
OBJECTIVE
To review the advances in gene expression of marrow stromal cells (MSCs) in biological characteristic, differentiation, gene therapy, supporting hematopoiesis, inflammation reaction in wound repair.


METHODS
The related articles in recent years were extensively reviewed.


RESULTS
MSCs can express not only specific mRNA of mesodermal cells but also that of endodermal and ectodermal cell types on various differentiation conditions. When transfected or transduction, MSCs can steadily express many therapeutic transgenes in vitro or in vivo as well. Furthermore, they have the ability to support hematopoietic system and participate in the process of inflammation in wound repair.


CONCLUSIONS
MSCs are stem cells which have the characteristic of self renewing, multi-potency and easy to expand in vitro. MSCs are ideal target cells for cell and gene therapies.
Han
Bing
B
Key Research Laboratory of Wound Repair of PLA, 304th Clinical Department, General Hospital of PLA, Beijing, 100037, PR China.
Fu
Xiaobing
X
Sun
Xiaoqing
X
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics; D015870:Gene Expression; D015316:Genetic Therapy / Q000379:methods; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D017154:Stromal Cells / Q000166:cytology / Q000378:metabolism*