title: A case of mucoepidermoid carcinoma with melanin pigmentation manifested in the palate.
abstract: This paper describes the first documented case of mucoepidermoid carcinoma (MEC) with melanin pigmentation manifested in the palate. Histopathological sections showed a neoplasm composed of epidermoid, mucous-producing and intermediate cells. Numerous large cells contained dark pigmented materials. Fontana Masson staining revealed dendritic melanocytes and melanin granules. HMB-45, Melan A and S-100 protein were all positive for melanocytes. Histopathological examination was not typical for malignant melanoma; the lesion was diagnosed as a low-grade MEC with melanin pigmentation.
authors.affiliation: Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. georges@net.nagasaki-u.ac.jp
authors.forename: Joji
authors.initials: J
authors.lastname: Sekine
authors.forename: Masanobu
authors.initials: M
authors.lastname: Anami
authors.forename: Shuichi
authors.initials: S
authors.lastname: Fujita
authors.forename: Michael
authors.initials: M
authors.lastname: Vieth
authors.forename: Tsugio
authors.initials: T
authors.lastname: Inokuchi
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000378:metabolism; D018277:Carcinoma, Mucoepidermoid / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D058965:MART-1 Antigen; D008543:Melanins / Q000378:metabolism*; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology; D008545:Melanoma / Q000175:diagnosis; D058950:Melanoma-Specific Antigens; D008548:Melanosis / Q000473:pathology*; D009363:Neoplasm Proteins / Q000378:metabolism; D010157:Palatal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism; D012470:Salivary Glands, Minor / Q000378:metabolism / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D008543:Melanins; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D009418:S100 Proteins