title: Synthetic approaches and total synthesis of natural zoapatanol.
abstract: [structure: see text] The total synthesis of (+)-zoapatanol utilizing an intramolecular Horner-Wadsworth-Emmons olefination and an enantioselective Sharpless dihydroxylation as the key steps has been achieved. An advanced oxepene intermediate has been obtained by applying a ring-closing metathesis to an unsaturated enol ether.
authors.affiliation: Laboratoire de Chimie Organique, associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Taillier
authors.forename: Barbara
authors.initials: B
authors.lastname: Gille
authors.forename: Véronique
authors.initials: V
authors.lastname: Bellosta
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
mesh_terms: D008968:Molecular Conformation; D010082:Oxepins / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D010082:Oxepins; C442248:zoapatanol