title: [Chondromodulin-I and its related gene Tenomodulin].
abstract: During endochondral bone formation, vascular invasion into the cartilaginous rudiments triggers the subsequent replacement of cartilage by bone. We have found that the cartilage-derived glycoprotein, Chondromodulin- I (ChM- I ), is involved in the anti-angiogenic property of cartilage, and that its absence creates a permissive microenvironment for vascular invasion in cartilage. Recently, we reported that a novel ChM- I related molecule, Tenomodulin (TeM), is specifically expressed in tendon, epimysium, ligaments, sclera, and cornea, all of which are hypovascular or avascular. In contrast to ChM- I that is secreted and accumulates in the extracellular matrix, TeM is expressed on the cell surface as a type II transmembrane protein. Anti-angiogenic properties of TeM and ChM- I in mesenchyme will be reviewed.
authors.affiliation: Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University.
authors.forename: Chisa
authors.initials: C
authors.lastname: Shukunami
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Oshima
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Nishizaki