title: Single neuron activity changes to interleukin-1beta in the orbitofrontal cortex of the rat.
abstract: The orbitofrontal cortex (OBF) is known to play important roles in various regulatory processes. Our preliminary behavioral studies showed homeostatic alterations after orbitofrontal cortical microinjection of interleukin-1beta (IL-1beta) in the rat. To elucidate whether the above alterations were due to direct neuronal action of the cytokine, extracellular single neuron activity was recorded in the OBF of anesthetized rats by means of tungsten fiber multibarreled glass microelectrodes during microelectrophoretic administration of IL-1beta. More than half (56%) of all cells tested changed in firing rate in response to IL-1beta. Approximately 90% of these cytokine-modulated neurons were also sensitive to microelectrophoretically applied d-glucose, that is, proved to be the elements of the central glucose-monitoring neural network. The present findings demonstrate that IL-1beta can exert direct modulatory role on neurons in the OBF.
authors.affiliation: Institute of Physiology and Neurophysiology Research Group of the Hungarian Academy of Sciences, Pécs University, Medical School, Pécs H-7624, Hungary. balazs.lukats@aok.pte.hu
authors.forename: Balázs
authors.initials: B
authors.lastname: Lukáts
authors.forename: Róbert
authors.initials: R
authors.lastname: Egyed
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Karádi
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005110:Extracellular Space / Q000187:drug effects; D005625:Frontal Lobe / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D005947:Glucose / Q000494:pharmacology; D006706:Homeostasis; D007375:Interleukin-1 / Q000494:pharmacology*; D007478:Iontophoresis; D008297:Male; D009415:Nerve Net / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects*; D051381:Rats
chemical_list: D007375:Interleukin-1; D005947:Glucose