Air-stable Ir-(P-Phos) complex for highly enantioselective hydrogenation of quinolines and their immobilization in poly(ethylene glycol) dimethyl ether (DMPEG).
An air-stable catalyst system Ir-(P-Phos) catalyst was found to be highly effective in the asymmetric hydrogenation of quinoline derivatives. The catalyst immobilized in DMPEG was efficiently recovered and reused eight times, retaining reactivity and enantioselectivity.
Xu
Lijin
L
Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Hong Kong, P.R. China.
Lam
Kim Hung
KH
Ji
Jianxin
J
Wu
Jing
J
Fan
Qing-Hua
QH
Lo
Wai-Hung
WH
Chan
Albert S C
AS
D000388:Air; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D017976:Phosphorus Acids / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry*; D013237:Stereoisomerism
C484978:(S)-ethyl 4,4-dimethyl pyroglutamate; D010720:Phosphines; D017976:Phosphorus Acids; D011804:Quinolines; D011092:Polyethylene Glycols; D007495:Iridium; C037219:quinoline; D011761:Pyrrolidonecarboxylic Acid