Lymphoid progenitors and primary routes to becoming cells of the immune system.
Extraordinary progress has been made in charting the maturation of hematopoietic cells. However, these charted processes do not necessarily represent obligate pathways to specialized types of lymphocytes. In fact, there is a degree of plasticity associated with primitive progenitors. Moreover, all lymphocytes of a given kind are not necessarily produced through precisely the same sequence of events. Particularly contentious is the nature of cells that seed the thymus, because different progenitors can generate T cells under experimental circumstances. Non-renewing progenitors with a high density of c-Kit in bone marrow are likely to replenish the thymus under normal circumstances and most closely resemble canonical T cell progenitors.
Pelayo
Rosana
R
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 NE 13(th) Street, Oklahoma City, OK 73104, USA.
Welner
Rob
R
Perry
S Scott
SS
Huang
Jiaxue
J
Baba
Yoshihiro
Y
Yokota
Takafumi
T
Kincade
Paul W
PW
D000818:Animals; D001853:Bone Marrow / Q000276:immunology / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D019009:Proto-Oncogene Proteins c-kit / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology / Q000502:physiology
D019009:Proto-Oncogene Proteins c-kit