The potential immunomodulatory effects of topical retinoids.
New research has refined our understanding of the immunopathophysiology of acne. Various immune factors, including both innate and adaptive immune responses, have been implicated in the pathophysiology of inflammatory acne. Topical retinoids such as tretinoin, adapalene, and tazarotene, exhibit immunomodulatory effects that may help to explain their efficacy in the resolution of inflammatory lesions.
Jones
David A
DA
Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. dajones@partners.org
D000152:Acne Vulgaris / Q000188:drug therapy / Q000276:immunology*; D000287:Administration, Topical; D000818:Animals; D003879:Dermatologic Agents / Q000276:immunology* / Q000627:therapeutic use; D006168:Guinea Pigs; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000503:physiopathology; D011425:Propionibacterium acnes / Q000187:drug effects / Q000276:immunology*; D012176:Retinoids / Q000276:immunology* / Q000627:therapeutic use; D051193:Toll-Like Receptors / Q000276:immunology
D003879:Dermatologic Agents; D012176:Retinoids; D051193:Toll-Like Receptors