[Study on the variation of platelet function in pregnancy induced hypertension and gestational diabetes mellitus].
OBJECTIVE
To investigate the platelet activity and function in pregnancy induced hypertension (PIH) and gestational diabetes mellitus (GDM).


METHODS
Twenty-one patients with GDM and 23 patients with PIH in third-trimester were included. Twenty normal pregnant women in third-trimester served as controls. Platelet count (PC), mean platelet volume (MPV) were determined on Cell-DYN 1600 and the expression of CD62P was analyzed on FACSC alibur.


RESULTS
(1) PC was (181 +/- 56) x 10(9)/L in PIH, (206 +/- 60) x 10(9)/L in GDM and (229 +/- 56) x 10(9)/L in controls, respectively. PC in PIH was lower than that of controls (P < 0.01), but there was no significant difference between GDM and controls. (2) MPV was (11.2 +/- 2.0) fl in PIH, significantly higher than that of controls (8.7 +/- 1.6) fl (P < 0.001). In GDM, MPV was (9.5 +/- 1.6) fl, without significant difference compared with that of controls. (3) The expression of CD62P increased significantly in PIH compared with controls [CD62P: (42 +/- 13)% vs (26 +/- 7)%, P < 0.001; CD62P(I): 109 +/- 39 vs 75 +/- 13, P < 0.01]. In GDM, the expression of CD62P also increased significantly compared with the normal pregnancy [CD62P(%): (42 +/- 14)% vs (26 +/- 7), P < 0.001; CD62P(I): 100 +/- 42 vs 75 +/- 13, P < 0.05]. (4) All parameters had no significant difference between PIH and GDM.


CONCLUSIONS
Platelet activity is enhanced in PIH and GDM. It may play an important role in the pathogenesis and development of the two diseases.
Yin
Song-mei
SM
Department of Hematology, Second Affiliated Hospital, Zhongshan University, Guangzhou 510120, China.
Li
Yi-qing
YQ
Xie
Shuang-feng
SF
Ma
Li-ping
LP
Wu
Yu-dan
YD
Nie
Da-nian
DN
Feng
Jian-hong
JH
Xu
Li-zhuo
LZ
D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood*; D015539:Platelet Activation; D010976:Platelet Count; D010980:Platelet Membrane Glycoproteins / Q000096:biosynthesis; D011247:Pregnancy
D010980:Platelet Membrane Glycoproteins