Relationship of granulocyte colony stimulating factor with other acute phase reactants in man.
The non-specific acute phase response in mice is associated with increased resistance to bacterial infection, which is critically mediated by granulocyte colony stimulating factor (G-CSF), but the behaviour of G-CSF in the human acute phase response is not known. Cardiothoracic surgery is a powerful acute phase stimulus and we show here that this procedure caused increased production of G-CSF, in addition to increases in the circulating concentrations of the proinflammatory cytokine interleukin (IL)-6 and the acute phase plasma proteins C-reactive protein (CRP) and serum amyloid A protein (SAA). Values of G-CSF correlated positively with IL-6 concentrations and circulating neutrophil counts, but not with CRP values. These results confirm that G-CSF is a physiological component of the acute phase response in humans that shares some of the same regulatory controls as IL-6, but its downstream effects are on neutrophils, not hepatic acute phase protein synthesis. Our observations are compatible with a protective role against bacterial infection for G-CSF in the human acute phase response, and support investigation of the prophylactic use of G-CSF in at-risk patients.
Noursadeghi
M
M
Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, Hammersmith Hospital, London, UK. Mahdad@Noursadeghi.net
Pepys
M B
MB
Gallimore
R
R
Cohen
J
J
D000209:Acute-Phase Proteins / Q000032:analysis*; D000210:Acute-Phase Reaction / Q000276:immunology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D006348:Cardiac Surgical Procedures / Q000379:methods; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D013510:Pulmonary Surgical Procedures / Q000379:methods; D000685:Serum Amyloid A Protein / Q000032:analysis
D000209:Acute-Phase Proteins; D015850:Interleukin-6; D000685:Serum Amyloid A Protein; D016179:Granulocyte Colony-Stimulating Factor; D002097:C-Reactive Protein