Signal-transduction pathways that regulate smooth muscle function. II. Receptor-ion channel coupling mechanisms in gastrointestinal smooth muscle.
Regulation of membrane ion channels by second messengers is an important mechanism by which gastrointestinal smooth muscle excitability is controlled. Receptor-mediated phosphorylation of Ca(2+) channels has been known for some time; however, recent findings indicate that these channels may also modulate intracellular signaling. The plasmalemma ion channels may also function as a point of convergence between different receptor types. In this review, the molecular mechanisms that link channel function and signal transduction are discussed. Emerging evidence also indicates altered second-messenger modulation of the Ca(2+) channel in the pathophysiology of smooth muscle dysmotility.
Akbarali
Hamid I
HI
Dept. of Physiology, Univ. of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA. hamid-akbarali@ouhsc.edu
D000818:Animals; D015220:Calcium Channels / Q000737:chemistry / Q000378:metabolism*; D005759:Gastroenteritis / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015290:Second Messenger Systems; D015398:Signal Transduction / Q000502:physiology*; D019061:src-Family Kinases / Q000378:metabolism
D015220:Calcium Channels; D011956:Receptors, Cell Surface; D019061:src-Family Kinases