[Pharmaceutical agents for calcium-induced cell damage (Na+/Ca2+ exchange inhibitor)].
Recently, a novel selective inhibitor of the Ca(2+) influx mode of the Na(+)/Ca(2+) exchanger, KB-R7943, has been developed. This compound is expected to be a pharmaceutical agent that offers effective protection against ischemia/reperfusion-associated injury in several organs such as heart and kidney. Here, we summarize pharmacological profiles of KB-R7943, the molecular mechanism of its action, and its future prospect as a novel pharmaceutical agent.
Iwamoto
T
T
Department of Molecular Physiology, National Cardiovascular Center Research Institute.
Kita
S
S
Shigekawa
M
M