Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice.
The non-obese diabetic (NOD) mouse spontaneously develops lymphocytic infiltrates in the salivary glands (sialadenitis) and provides an useful rodent model of human Sjogren's syndrome (SS). Non-depleting anti-CD4 antibodies have been shown to ameliorate Type 1 diabetes in NOD mice and also vasculitis in MRL/lpr mice. This study shows that a short course of treatment with the non-depleting anti-CD4 monoclonal antibody, YTS 177, completely prevents salivary infiltration and reverses ongoing pathology in the salivary gland.
Thompson
Clare
C
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Jacobsen
Helle
H
Pomeranz Krummel
Daniel
D
Nagai
Kyoshi
K
Cooke
Anne
A
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D015704:CD4 Antigens / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D051379:Mice; D019463:Mice, Inbred MRL lpr; D016688:Mice, Inbred NOD; D012469:Salivary Glands / Q000276:immunology* / Q000473:pathology; D012793:Sialadenitis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D012859:Sjogren's Syndrome / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens