[Relationship of plasma nitric oxide concentration and the activity of nitric oxide synthase with coronary heart disease].
OBJECTIVE
To study the levels of nitric oxide synthase (NOS) and nitric oxide (NO) in patients with coronary heart disease (CHD), and the factors affecting them.


METHODS
Concentrations of NO and the activities of NOS in plasma in 136 patients and 206 controls using the corresponding Kits were measured. The data were analyzed using covariance and multiple linear regression analysis with SAS 8.1.


RESULTS
The levels of NO [(217.05 +/- 153.31) micromol/L] and NOS [(14.09 +/- 7.14) U/ml] in patients were significantly higher than that in the healthy controls [(140.69 +/- 90.96) micromol/L, (7.75 +/- 3.79) U/ml, respectively, P < 0.01]. Smoking and drinking were the independent risk factors for NOS, while sex was the independent risk factor for NO (P < 0.01).


CONCLUSIONS
The levels of plasma NO and NOS are closely related with coronary heart disease.
Wang
Feng
F
Institute of Occupational Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Gao
Chao
C
He
Mei-An
MA
Jiang
Chang-Zheng
CZ
Yang
Miao
M
Zhang
Li-Yun
LY
Wu
Tang-Chun
TC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009569:Nitric Oxide / Q000097:blood*; D019001:Nitric Oxide Synthase / Q000097:blood*; D010949:Plasma / Q000378:metabolism
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase