Is postoperative calcium channel blocker therapy needed in patients with radial artery grafts?
BACKGROUND
Chronic calcium channel blocker therapy has traditionally been considered necessary in patients carrying a radial artery graft, even in the absence of objective data to support it. This report was conceived to evaluate the angiographic and clinical effects of calcium channel blocker therapy during the first postoperative year.


RESULTS
A total of 100 consecutive patients who received a radial artery graft at our institution were randomly assigned to receive (n = 53) or not receive (n = 47) calcium channel blocker therapy with oral diltiazem 120 mg/daily started in the early postoperative period. At 1-year follow-up, all patients were reassessed clinically and by Tl 201 myocardial scintigraphy, and 83 of them underwent control angiography. In 12 cases we also evaluated the response of the radial artery to the endovascular infusion of serotonin. No difference in terms of clinical outcome, scintigraphic results, and patency rate was found between patients who received or did not receive calcium channel blocker therapy. Endovascular serotonin infusion evoked an evident spastic reaction of radial artery grafts, not attenuated by calcium channel blocker therapy.


CONCLUSIONS
Calcium channel blocker therapy started immediately after surgery and continued for the first postoperative year does not affect radial artery graft patency and clinical and scintigraphic outcomes. On the basis of these data, the prophylactic use of calcium channel blocker therapy in patients with radial artery grafts seems unsubstantiated.
Gaudino
Mario
M
Department of Cardiac Surgery, Catholic University, Rome, Italy. mgaudino@tiscali.it
Luciani
Nicola
N
Nasso
Giuseppe
G
Salica
Andrea
A
Canosa
Carlo
C
Possati
Gianfederico
G
D000368:Aged; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000379:methods; D004110:Diltiazem / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D011184:Postoperative Period; D017534:Radial Artery / Q000637:transplantation*; D014654:Vascular Patency / Q000187:drug effects*
D002121:Calcium Channel Blockers; D004110:Diltiazem