title: Unusual association of multiple sclerosis with monoclonal gammopathy of undetermined significance (MGUS): two case reports.
abstract: We present two patients with demyelinating disease meeting the diagnostic criteria for multiple sclerosis. Both patients had IgG lambda monoclonal gammopathy in serum and cerebrospinal fluid associated with intrathecal antibody synthesis. This association is very unusual and it is not certain whether the co-occurrence of these disorders might be the result of a causal link between multiple sclerosis and monoclonal gammopathy or a fortuitous phenomenon.
authors.affiliation: Department of Neurology, Aeginition Hospital-Athens Medical School, Athens, Greece. mrentzos@med.uoa.gr
authors.forename: Michael
authors.initials: M
authors.lastname: Rentzos
authors.forename: Maria
authors.initials: M
authors.lastname: Michalopoulou
authors.forename: Kostas
authors.initials: K
authors.lastname: Gotosidis
authors.forename: Anna
authors.initials: A
authors.lastname: Caponi
authors.forename: Anastasios
authors.initials: A
authors.lastname: Bonakis
authors.forename: Kostas
authors.initials: K
authors.lastname: Kilidireas
authors.forename: Chrissoula
authors.initials: C
authors.lastname: Nikolaou
mesh_terms: D000911:Antibodies, Monoclonal / Q000097:blood / Q000134:cerebrospinal fluid; D000917:Antibody Formation; D001921:Brain / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D007525:Isoelectric Focusing; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000276:immunology; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis; D043025:Oligoclonal Bands / Q000097:blood / Q000134:cerebrospinal fluid; D013116:Spinal Cord / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D043025:Oligoclonal Bands