Specificities of B cell reactions to drugs. The penicillin model.
Betalactams conjugate to protein carriers induced T and B cell effector responses. From these, IgE dependent reactions are the most common and better defined. These antibodies recognize a number of structures that can cross react or selective recognition may occur. The great variability in the chemical structure, specifically at the position R of penicillin and R1 of cephallosporins has made that the recognition of these structures may have clinical relevance in the evaluation of patients allergic to betalactams.
Blanca
Miguel
M
Allergy Service and Research Unit for Allergic Diseases, Carlos Haya Hospital, Plaza del Hospital Civil s/n, 29009 Malaga, Spain. miguel.blanca.sspa@juntadeandalucia.es
Cornejo-Garcia
J A
JA
Torres
M J
MJ
Mayorga
C
C
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D010406:Penicillins / Q000737:chemistry / Q000276:immunology*; D047090:beta-Lactams / Q000009:adverse effects / Q000276:immunology
D000900:Anti-Bacterial Agents; D010406:Penicillins; D047090:beta-Lactams