New phosphite-oxazoline ligands for efficient Pd-catalyzed substitution reactions.
We have designed and synthesized a new family of readily available highly modular phosphite-oxazoline ligands for the Pd-catalyzed asymmetric allylic substitution reactions. The introduction of a pi-acceptor flexible bulky biphenyl phosphite moiety in the ligand design is highly adventitious in the product outcome. Thus, this ligand series affords excellent reaction rates (TOF's up to >2400 mol.(mol.h)-1) and enantioselectivities (ee's up to >99%) and, at the same time, shows a broad scope for different substrate types.
Pàmies
Oscar
O
Universitat Rovitat i Virgili, Departament de Química Física i Inorgànica, C/ Marcel.lí Domingo s/n., 43007 Tarragona, Spain. oscar.pamies@urv.net
Diéguez
Montserrat
M
Claver
Carmen
C