[Bisphosphonate and markers for bone metabolism].
Bisphosphonates (BPs) are widely applied to clinical use as first lines of therapeutic agents for metabolic bone diseases such as osteoporosis and Paget's disease of bone. Data on changes in markers for bone metabolism and their abilities to predict treatment efficacy have been accumulated in these bone disease and recently a guideline for adequate use of markers for metabolism in osteoporosis has been proposed. In the use of BPs, particularly ones containing amino residuals in their structures of side chains, attention should be paid to the choice of markers for bone metabolism since their degrees of changes depends on markers selected.
Nakatsuka
K
K
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine.