title: Absence of association of inherited thrombophilia with unexplained third-trimester intrauterine fetal death.
abstract: OBJECTIVE
  The purpose of this study was to investigate the alleged association between thrombophilia and unexplained third-trimester stillbirth.
  
  
  METHODS
  Case subjects were 37 women with a history of a third-trimester unexplained stillbirth. Control subjects were 46 volunteers, group-matched for ethnic origin, with no history of stillbirth, recurrent fetal loss, or thromboembolism. The pathology report of 34/37 placentas of case subjects was reviewed.
  
  
  RESULTS
  The prevalence of at least 1 inherited thrombophilia among case subjects was 37.8% compared with 41.3% among control subjects. (OR = 0.87; 95%CI, 0.32-2.29). There was no significant difference between the groups with respect to the prevalence of any single inherited thrombophilia. There was, however, a significantly higher prevalence of antiphospholipid antibodies among case subjects compared with control subjects: 47.2% vs 8.7%, respectively (OR = 9.4; 95%CI, 2.5-42.3). No significant difference was noted in the prevalence of thrombopilia among subjects with or without placental infarcts.
  
  
  CONCLUSIONS
  We did not find an association between unexplained third-trimester intrauterine fetal death and inherited thrombophilia; however, we did find such an association with antiphospholipid antibodies.
authors.affiliation: Department of Obstetrics and Gynecology, Bnai Zion Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Ron
authors.initials: R
authors.lastname: Gonen
authors.forename: Noa
authors.initials: N
authors.lastname: Lavi
authors.forename: Dina
authors.initials: D
authors.lastname: Attias
authors.forename: Liliana
authors.initials: L
authors.lastname: Schliamser
authors.forename: Zvi
authors.initials: Z
authors.lastname: Borochowitz
authors.forename: Elias
authors.initials: E
authors.lastname: Toubi
authors.forename: Gonen
authors.initials: G
authors.lastname: Ohel
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000097:blood; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D006801:Humans; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D015995:Prevalence; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics
chemical_list: D017152:Antibodies, Antiphospholipid