title: Fumonisins in foods from Cordoba (Argentina), presence and genotoxicity.
abstract: Fumonisins B(1), B(2)yB(3) (FB(1), FB(2)yFB(3)), are a group of toxins produced by different mold species, Fusarium moniliforme and Fusarium proliferatum being the most important ones. Its compounds were tested in chromosome aberrations (CA), sister chromatid exchange (SCE), and micronucleus (MN) in human lymphocytes, and, in Allium cepa (onion), the chromosomal aberrations (CA) assay was used. Moreover, the presence of fumonisins and their producer moulds was determined in different food substrata in Cordoba city, Argentina. Cytogenetic studies using FB(1), FB(2) and FB(3) levels gave positive results for the higher concentrations (5 and 10mug/g) with FB(1). As regards the cytogenetic aspect of FB(1), we found an increase in the incidence of genetic damage measured by chromosomal aberrations, sister chromatid exchange, micronuclei and chromosomal aberrations in Allium cepa. These results indicate that human lymphocytes cells and plants cells (Allium cepa) have a very sensitive cellular response to the mycotoxin fumonisin B(1) as observed at the highest concentrations.
authors.affiliation: Facultad de Ciencias Químicas, Universidad Católica de Córdoba, Campus: camino a Alta Gracia Km 7.5, 5000 Córdoba, Argentina. dlerda@coyspu.com.ar
authors.forename: D
authors.initials: D
authors.lastname: Lerda
authors.forename: M
authors.initials: M
authors.lastname: Biaggi Bistoni
authors.forename: N
authors.initials: N
authors.lastname: Peralta
authors.forename: S
authors.initials: S
authors.lastname: Ychari
authors.forename: M
authors.initials: M
authors.lastname: Vazquez
authors.forename: G
authors.initials: G
authors.lastname: Bosio
mesh_terms: D001118:Argentina; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D004305:Dose-Response Relationship, Drug; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis; D037341:Fumonisins / Q000032:analysis* / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis / Q000633:toxicity*; D019697:Onions / Q000187:drug effects* / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000235:genetics
chemical_list: D037341:Fumonisins; D009153:Mutagens; C056934:fumonisin B2; C073063:fumonisin B3; C056933:fumonisin B1