Synthetic peptide arrays and peptide combinatorial libraries for the exploration of protein-ligand interactions and the design of protein inhibitors.
Synthetic peptides have a long tradition as molecular tools in biomedical research and drug discovery. The introduction of high-throughput synthesis and screening technologies for synthetic peptides, such as arrays and combinatorial libraries, enabled the large-scale and detailed exploration of protein-ligand interactions, as well as the discovery of novel biologically active peptides. This review summarizes currently available synthetic peptide array and library technologies, in particular mixture-based peptide libraries, which are illustrated by numerous applications in various fields of biomedical research.
Eichler
Jutta
J
GBF - German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany. jei@gbf.de
D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D004347:Drug Interactions; D008024:Ligands; D008967:Molecular Biology / Q000379:methods; D009842:Oligopeptides / Q000138:chemical synthesis*; D019151:Peptide Library; D040081:Protein Array Analysis; D011506:Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry*
D008024:Ligands; D009842:Oligopeptides; D019151:Peptide Library; D011506:Proteins