title: Effect modification by vitamin C on the relation between gastric cancer and Helicobacter pylori.
abstract: A hospital-based case-control study of 295 cases with histologically confirmed gastric cancer and age and sex-matched controls was conducted to evaluate the effect of dietary vitamin C intake upon the relation between Helicobacter pylori infection and gastric cancer in Korea in 1997-1998. Anti-H. pylori IgG was detected by ELISA. A food frequency questionnaire, and a questionnaire on demographic factors, including past medical history, smoking, alcohol consumption, and life style was also administered. The prevalences of H. pylori IgG in cases and controls were 80.7% and 71.2%, respectively, and the odds ratio (OR) of H. pylori for gastric cancer was 1.68 (95% confidence interval (CI): 1.14, 2.44), after adjusting for age, sex, educational level, and a past medical history of gastritis or gastric ulcer. In a stratified analysis, H. pylori seropositivity was found to be a significant risk factor for gastric cancer in the low vitamin C intake group (OR = 4.68; 95% CI: 1.97, 11.1), but not in the high vitamin C intake group (OR = 0.72; 95% CI: 0.32, 1.65). Vitamin C intake was found to modify the relation between H. pylori and gastric cancer.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Dae-Sung
authors.initials: DS
authors.lastname: Kim
authors.forename: Moo-Song
authors.initials: MS
authors.lastname: Lee
authors.forename: Young-Sik
authors.initials: YS
authors.lastname: Kim
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Jong-Myon
authors.initials: JM
authors.lastname: Bae
authors.forename: Myung-Hee
authors.initials: MH
authors.lastname: Shin
authors.forename: Yoon-Ok
authors.initials: YO
authors.lastname: Ahn
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage*; D016022:Case-Control Studies; D005260:Female; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007723:Korea; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D013274:Stomach Neoplasms / Q000382:microbiology*; D011795:Surveys and Questionnaires
chemical_list: D007074:Immunoglobulin G; D001205:Ascorbic Acid