title: Surgical management of parapharyngeal space tumors: a 10-year review.
abstract: OBJECTIVE
  The purpose of this article is to describe the diagnostic evaluation and surgical approaches to parapharyngeal space tumors in a tertiary referral center.
  
  
  METHODS
  The study is a retrospective review of 47 patients diagnosed with tumors of the parapharyngeal space (12 with malignant diseases and 35 with benign lesions) and surgically treated during a 10-year period. The transcervical (40%) and the transcervical-transparotid approaches (46%) were the most commonly performed surgical procedures followed by the orbitozygomatic-middle fossa approach (12%) and the transmandibular approach (2%).
  
  
  RESULTS
  The surgical procedures were uneventful and there were no postoperative mortalities. Complications were rare; the most common was transient facial nerve paralysis (5 patients). After an average follow-up of 35 months, only 1 of 35 patients with benign diseases had a recurrence 5 years following transcervical resection of a pleomorphic adenoma. Of 12 patients with malignant tumors, 5 (42%) are alive with no evidence of disease. The sensitivity of preoperative fine needle aspiration biopsy (n = 23 patients) was 87% for detection of malignant disease and specificity was 100%.
  
  
  CONCLUSIONS
  Most benign parapharyngeal space tumors can be removed surgically with a low rate of complications and recurrence. Malignant neoplasms, however, carry an ominous prognosis and a low rate of disease-free survival. Fine needle aspiration may be helpful in preoperative diagnostic evaluation of patients with parapharyngeal space tumors.
authors.affiliation: Head and Neck and Skull-base Unit, Department of Otolaryngology-Head and Neck Surgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Sackler School of Medicine, Israel.
authors.forename: Avi
authors.initials: A
authors.lastname: Khafif
authors.forename: Yoram
authors.initials: Y
authors.lastname: Segev
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Kaplan
authors.forename: Ziv
authors.initials: Z
authors.lastname: Gil
authors.forename: Dan M
authors.initials: DM
authors.lastname: Fliss
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010614:Pharynx; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative / Q000379:methods; D013997:Time Factors