Integrin-actin interactions.
The integrin family of extracellular matrix receptors regulates many aspects of cell life, in particular cell adhesion and migration. These two processes depend on organization of the actin cytoskeleton into adhesive and protrusive organelles in response to extracellular signals. Integrins are important switch points for the spatiotemporal control of actin-based motility in higher eukaryotes. Ligands of integrin cytoplasmic tails are central elements of signalling pathways involving small GTPases as well as protein and lipid kinases in the regulation of Factin crosslinking, actin treadmilling and de novo nucleation of actin filaments. We present an overview of common pathways and discuss recent evidence for their differential use by individual integrin receptors.
Wiesner
S
S
Department of Molecular Medicine, Max-Planck-Institut of Biochemistry, Martinsried, Germany. wiesner@biochem.mpg.de
Legate
K R
KR
Fässler
R
R
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008840:Microfilament Proteins / Q000378:metabolism; D008954:Models, Biological; D011485:Protein Binding; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D000199:Actins; D003598:Cytoskeletal Proteins; D016023:Integrins; D008840:Microfilament Proteins; D011494:Protein Kinases