title: Endothelial function is preserved in Chagas' heart disease patients without heart failure.
abstract: Endothelium may be damaged, especially at the coronary microcirculation, in animal models of Chagas' disease by several mechanisms. Endothelial dysfunction has been reported in chronic Chagas' heart disease patients with heart failure. Nevertheless, peripheral endothelial function has never been studied in patients with Chagas' heart disease without heart failure and other conditions that could per se alter the endothelial function. Endothelial function was evaluated in 9 patients with Chagas' heart disease (44.8 +/- 1.5 years, 5 females, left ventricular ejection fraction > or = 60%) and 10 healthy matched controls (38.6 +/- 5.5 years, 5 females). Extreme caution was exercised to select patients with no other conditions that could per se alter the endothelial function. Forearm blood flow was measured at baseline and during intra-brachial artery infusion of crescent doses of acetylcholine (0.75, 5, and 15 microg/100 mL tissue/min) and nitroprusside (1, 2, and 4 microg/ 100 mL tissue/min), an endothelium-dependent and an endothelium-independent vasoactive drug, respectively. At baseline, blood pressure and heart rate (continuously recorded with Finapress) and the forearm blood flow were similar in both groups. Acetylcholine (ACh) and sodium nitroprusside (SNP) caused significant and similar dose-dependent increases in forearm blood flow of all subjects: maximum ACh response of 24.8 versus 23.7, and maximum SNP response 24.4 versus 23.7 mL/100 mL tissue/min, respectively, for control and chagasic Groups. No significant systemic hemodynamic changes were observed during the intra-arterial infusion of the drugs. The authors conclude that the peripheral endothelial function is preserved in Chagas' heart disease patients without heart failure.
authors.affiliation: Heart Institute (InCor), Medical School, University of São Paulo, Brazil. hipfernanda@incor.usp.br
authors.forename: Fernanda M
authors.initials: FM
authors.lastname: Consolim-Colombo
authors.forename: Heno F
authors.initials: HF
authors.lastname: Lopes
authors.forename: Eliana A
authors.initials: EA
authors.lastname: Rosetto
authors.forename: Marcelo C
authors.initials: MC
authors.lastname: Rubira
authors.forename: José Augusto S
authors.initials: JA
authors.lastname: Barreto-Filho
authors.forename: Antonio Cláudio A
authors.initials: AC
authors.lastname: Baruzzi
authors.forename: Nazareth N
authors.initials: NN
authors.lastname: Rocha
authors.forename: Charles
authors.initials: C
authors.lastname: Mady
authors.forename: Maria Claudia
authors.initials: MC
authors.lastname: Irigoyen
authors.forename: Eduardo M
authors.initials: EM
authors.lastname: Krieger
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002598:Chagas Cardiomyopathy / Q000188:drug therapy / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D009599:Nitroprusside; D000109:Acetylcholine