[Pressure-induced expression of immediate-early gene product c-Jun of the common carotid arteries in rats].
In order to investigate the mechanism of mechanical stress-mediated arterial remodeling, we studied the pressure-induced expression of immediate-early response gene product c-Jun in common carotid arteries in rats. The common carotid arteries were perfused with both high pressure (160 mmHg) and normal pressure (80 mmHg) for 0.5, 1, 3 and 6 hours. Expression of immediate-early response gene product c-Jun in the arteries was examined by immunohistochemistry and computer image processing. c-Jun was weakly expressed at 1 h, then increased at 3 h and 6 h after exposure of the arteries to normal pressure. Positive immunohistochemical product of c-Jun appeared in the arteries at 0.5 h after the onset of high pressure, then it increased markedly till 6 h. There was significant difference between the two groups. These results indicate that expression of c-Jun of the arteries can be induced by pressure, which may play an important role in mechanical stress-mediated arterial remodeling.
Yan
Zhiqiang
Z
Laboratory of Biomechanics, School of Medicine, Shanghai Jioatong University, Shanghai 200030, China.
Jiang
Zonglai
Z
Zhang
Yan
Y
Yang
Xiangqun
X
D000818:Animals; D001696:Biomechanical Phenomena; D017536:Carotid Artery, Common / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D017781:Genes, Immediate-Early; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism*; D011312:Pressure; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical
D016755:Proto-Oncogene Proteins c-jun