Sensitivity analysis for trend tests: application to the risk of radiation exposure.
Trend tests are used to assess the relationship between multiple level treatment X and binary response R. In observational studies, however, there may be a confounder U that is associated with treatment X and causally related to response R. When the data for the confounder U are not observed, an approach for assessing the sensitivity of test results to U is provided. Its use is illustrated by examining data from a study of mutation rate after the Chernobyl accident.
Yu
Binbing
B
Information Management Services, Inc., 12501 Prosperity Dr. Suite 200, Silver Spring, MD 20904, USA. yub@imsweb.com
Gastwirth
Joseph L
JL
D047852:Chernobyl Nuclear Accident; D015986:Confounding Factors, Epidemiologic; D003627:Data Interpretation, Statistical; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure; D018095:Germ-Line Mutation / Q000528:radiation effects*; D006801:Humans; D018895:Microsatellite Repeats / Q000528:radiation effects*; D011839:Radiation, Ionizing; D011847:Radioactive Fallout; D002094:Republic of Belarus; D012680:Sensitivity and Specificity
D011847:Radioactive Fallout