Hepatoprotective and antioxidant effects of Morus bombycis Koidzumi on CCl4-induced liver damage.
The antioxidant activity and liver protective effect of Morus bombycis Koidzumi were investigated. Aqueous extracts of M. bombycis Koidzumi had higher superoxide radical scavenging activity than other types of extracts. The aqueous extract at a dose of 100 mg/kg showed significant hepatoprotective activity when compared with that of a standard agent. The biochemical results were confirmed by histological observations indicating that M. bombycis Koidzumi extract together with CCl(4) treatment decreased ballooning degeneration. The water extract recovered the CCl(4)-induced liver injury and showed antioxidant effects in assays of FeCl(2)-ascorbic acid-induced lipid peroxidation in rats. Based on these results, we suggest that the hepatoprotective effect of the M. bombycis Koidzumi extract is related to its antioxidative activity.
Jin
Ying-Shan
YS
Division of Biotechnology, Kangwon National University, Chuncheon, Kangwon-do 200-701, Republic of Korea.
Sa
Jae-Hoon
JH
Shim
Tae-Heum
TH
Rhee
Hae-Ik
HI
Wang
Myeong-Hyeon
MH
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002251:Carbon Tetrachloride; D004305:Dose-Response Relationship, Drug; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D031625:Morus / Q000737:chemistry*; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D016896:Treatment Outcome
D000975:Antioxidants; D010936:Plant Extracts; D002251:Carbon Tetrachloride