title: Dithranol irritation in psoriasis treatment: a study of 68 inpatients.
abstract: The irritant response of perilesional skin is a serious limitation of dithranol therapy in psoriasis. No data are available on the actual prevalence and severity of irritation during 24-h dithranol treatment in an inpatient setting. Using a retrospective analysis of 68 patients with psoriasis visiting our inpatient department for dithranol treatment, the occurrence of dithranol irritation was studied. We found a relatively high frequency of dithranol irritation. Furthermore, most irritation occurs at the start of the therapy with relatively low concentrations.
authors.affiliation: Department of Dermatology, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands. mku@sder.azm.nl
authors.forename: M
authors.initials: M
authors.lastname: Kucharekova
authors.forename: L
authors.initials: L
authors.lastname: Lieffers
authors.forename: P C M
authors.initials: PC
authors.lastname: van de Kerkhof
authors.forename: P G M
authors.initials: PG
authors.lastname: van der Valk
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000875:Anthralin / Q000009:adverse effects* / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D000875:Anthralin