Endometrial polyps and their implication in the pregnancy rates of patients undergoing intrauterine insemination: a prospective, randomized study.
BACKGROUND
It was our intention to determine whether hysteroscopic polypectomy before intrauterine insemination (IUI) achieved better pregnancy outcomes than no intervention.


METHODS
A total of 215 infertile women from the infertility unit of a university tertiary hospital with ultrasonographically diagnosed endometrial polyps (EP) undergoing IUI were randomly allocated to one of two pretreatment groups using an opaque envelope technique with assignment determined by a random number table. Hysteroscopic polypectomy was performed in the study group. Diagnostic hysteroscopy and polyp biopsy was performed in the control group.


RESULTS
Total pregnancy rates and time for success in both groups after four IUI cycles were compared by means of contingency tables and life-table analysis. A total of 93 pregnancies occurred, 64 in the study group and 29 in the control group. Women in the study group had a better possibility of becoming pregnant after polypectomy, with a relative risk of 2.1 (95% confidence interval 1.5-2.9). Pregnancies in the study group were obtained before the first IUI in 65% of cases.


CONCLUSIONS
These data suggest that hysteroscopic polypectomy before IUI is an effective measure.
Pérez-Medina
Tirso
T
Department Of Gynaecology, Santa Cristina University Hospital, Universidad Autónoma de Madrid, C/O'Donnell 59, 28009 Madrid, Spain. tperezm@meditex.es
Bajo-Arenas
José
J
Salazar
Francisco
F
Redondo
Teresa
T
Sanfrutos
Luis
L
Alvarez
Pilar
P
Engels
Virginia
V
D000328:Adult; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D011127:Polyps / Q000150:complications / Q000601:surgery*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D014591:Uterine Diseases / Q000150:complications / Q000601:surgery*; D014599:Uterus