[The mechanisms of the development and progression of diabetic macrovascular complications].
Patients with diabetes mellitus increases in number in recent years and atherosclerosis-related vascular complications are the major cause of death in diabetic patients. A massive cluster of macrophage-derived foam cells in the subendothelial spaces is one of the characteristic features of the early stages of atherosclerotic lesions. In the present work, we mainly focused on the possible links of glycated-proteins and AGE-modified proteins to the development and progression of diabetic macrovascular complications.
Sakai
Masakazu
M
Department of Medical Biochemistry, Kumamoto University Graduate School of Medical and Pharmaceutical sciences.
Sakamoto
Yu-ichiro
Y
Horiuchi
Seikoh
S