title: Amygdala activation to sad pictures during high-field (4 tesla) functional magnetic resonance imaging.
abstract: Fear-related processing in the amygdala has been well documented, but its role in signaling other emotions remains controversial. The authors recovered signal loss in the amygdala at high-field strength using an inward spiral pulse sequence and probed its response to pictures varying in their degree of portrayed sadness. These pictures were presented as intermittent task-irrelevant distractors during a concurrent visual oddball task. Relative to neutral distractors, sad distractors elicited greater activation along ventral brain regions, including the amygdala, fusiform gyrus, and inferior frontal gyrus. In contrast, oddball targets engaged dorsal sectors of frontal, parietal, and cingulate cortices. The amygdala's role in emotional evaluation thus extends to images of grief and despair as well as to those depicting violence and threat.
authors.affiliation: Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA.
authors.forename: Lihong
authors.initials: L
authors.lastname: Wang
authors.forename: Gregory
authors.initials: G
authors.lastname: McCarthy
authors.forename: Allen W
authors.initials: AW
authors.lastname: Song
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Labar
mesh_terms: D000328:Adult; D000679:Amygdala / Q000502:physiology*; D001288:Attention / Q000502:physiology; D001921:Brain / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000502:physiology*; D012016:Reference Values