Effects of CGS-12066A on medial vestibular nuclear neurons.
This study aims to explore the effects of a selective 5-HT1B receptor agonist, CGS-12066A, on the neuronal excitability of the rat medial vestibular nuclear neurons. The spontaneous firing rate was decreased, and the membrane potential was hyperpolarized by CGS-12066A. The whole potassium currents were inhibited by CGS-12066A. After the calcium-dependent potassium, currents were blocked, however, CGS-12066A did not inhibit the potassium currents, suggesting that the 5-HT action site is calcium-dependent potassium currents.
Jeong
Han-Seong
HS
Department of Physiology, Chonnam National University Medical School, Gwangju 501-190, South Korea.
Jang
Myung-Joo
MJ
Park
Jong-Seong
JS
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009924:Organ Culture Techniques; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects; D011810:Quinoxalines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D014726:Vestibular Nuclei / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D015221:Potassium Channels; D011810:Quinoxalines; D017366:Serotonin Receptor Agonists; C052561:CGS 12066B; D002118:Calcium