title: Effects of renal denervation of the contralateral kidney on blood pressure and sodium and eicosanoid excretion in the chronic phase of two-kidney, one-clip renovascular hypertension in rats.
abstract: OBJECTIVE
  To define the role of the renal nerves of the contralateral kidney in the maintenance of two-kidney, one-clip (2K-1C) renovascular hypertension in rats.
  
  
  METHODS
  The contralateral kidney of 2K-1C rats was denervated 6 months after induction of hypertension and 4 weeks after nephrectomy of the clipped kidney. Blood pressure, sodium and potassium balance and eicosanoid excretion were measured.
  
  
  RESULTS
  Denervation of the contralateral kidney induced normalization of blood pressure in post-Goldblatt hypertensive rats. This effect was not mediated by a negative sodium balance. Excretion of prostaglandin E2 and thromboxane B2 increased after denervation of the contralateral kidney in both post-Goldblatt hypertensive and post-Goldblatt normotensive rats, while urine extraction remained unaffected.
  
  
  CONCLUSIONS
  Afferences from the contralateral kidney appear to participate in the maintenance of 2K-1C renovascular hypertension due to the activation of central mechanisms regulating blood pressure.
authors.affiliation: Department of Urology, University of Thrace, 68100 Alexandroupolis, Greece. chkalaitzis@hotmail.com
authors.forename: Christos
authors.initials: C
authors.lastname: Kalaitzis
authors.forename: Stavros
authors.initials: S
authors.lastname: Touloupidis
authors.forename: Evangelos
authors.initials: E
authors.lastname: Bantis
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Patris
authors.forename: Argyrios
authors.initials: A
authors.lastname: Triantafyllidis
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003714:Denervation; D015232:Dinoprostone / Q000652:urine; D015777:Eicosanoids / Q000652:urine*; D006978:Hypertension, Renovascular / Q000378:metabolism* / Q000503:physiopathology; D007668:Kidney / Q000294:innervation*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000378:metabolism; D013929:Thromboxane B2 / Q000652:urine; D013997:Time Factors
chemical_list: D015777:Eicosanoids; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D012964:Sodium; D015232:Dinoprostone