[Inhibitory effect of grape procyanidin on the cell apoptosis induced by radiation].
OBJECTIVE
To study the inhibition effect of grape procyanidin (GPC) on the cell apoptosis and injury of proliferation induced by radiation.


METHODS
Three indices including apoptosis rate, proliferation rate and expression of bcl-2 and bax protein were examined in the mice pancreas after taking different dose GPC by mouth and radiation by (60)Co-gamma ray once.


RESULTS
The cell proliferation and bcl-2 expression in high dose GPC group (3.16% +/- 0.13% and 49.8% respectively), were higher than those in radiation control group (0.64% +/- 0.11%, 29.7%), but the cell apoptosis rate and bax expression (19.8% and 55.0% respectively), were lower than those in radiation control group (35.6%, 85.7%). All the above differences were statistically significant (P < 0.05).


CONCLUSIONS
GPC has certain protective effect against the mice pancreatic cell apoptosis and the abnormal expression of bcl-2 and bax protein induced by (60)Co-gamma.
Liu
Hai-Zhen
HZ
Weifang People's Hospital, Weifang, Shandong Province 261041, China.
Zhong
Jin-Yi
JY
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects*; D044946:Biflavonoids / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D049109:Cell Proliferation; D051379:Mice; D008815:Mice, Inbred Strains; D010179:Pancreas / Q000166:cytology* / Q000187:drug effects / Q000528:radiation effects; D044945:Proanthocyanidins / Q000494:pharmacology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2; D027843:Vitis / Q000737:chemistry*; D051028:bcl-2-Associated X Protein / Q000378:metabolism
C494827:Bax protein, mouse; D044946:Biflavonoids; D044945:Proanthocyanidins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; C052617:Bcl2 protein, mouse; C017674:procyanidin; D002392:Catechin