title: Exercise your amyloid.
abstract: The interplay of genetics and the environment in the etiology of Alzheimer's disease (AD) is not well understood. Now, Lazarov and coworkers show that a simple paradigm of environmental enrichment alleviates amyloid burden and alters disease-associated gene expression changes in a double transgenic mouse model of AD.
authors.affiliation: Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
authors.forename: Stanislav L
authors.initials: SL
authors.lastname: Karsten
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Geschwind
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D004780:Environment, Controlled; D005106:Exploratory Behavior / Q000502:physiology; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D015260:Neprilysin / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D015260:Neprilysin