title: The development of a physiologically-based pharmacokinetic model using the distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the tissues of the eastern oyster (Crassostrea virginica).
abstract: A physiologically-based pharmacokinetic model (PBPK) was developed to describe the kinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the eastern oyster (Crassostrea virginica). The estimated t(1/2) of elimination for a bolus dose of TCDD in C. virginica is approximately 14-24 days based on both the experimental data and the PBPK model. The highest dioxin concentration reached during 28-days was in the digestive gland followed by the mantle, gonad, hemolymph, gill, adductor muscle, and the kidney/heart. A binding protein for 2,3,7,8-TCDD had been reported in the literature for both the digestive gland and gonad. Incorporating a binding component in the model resulted in a better fit for the data. The PBPK model predicted the distribution and the elimination concentrations for 2,3,7,8-TCDD within each of the tissue compartments. This model will serve as a useful tool for predicting the kinetics of other persistent organic pollutants as well as, allow for a more refined ecological risk assessment by estimating dioxin concentrations in sensitive tissues such as the gonad.
authors.affiliation: Department of Biochemistry and Microbiology, The State University of New Jersey, Rutgers, Cook College, 76 Lipman Drive, New Brunswick, NJ 08901-8525, USA. takacs.margy@epa.gov
authors.forename: Margy
authors.initials: M
authors.lastname: Wintermyer
authors.forename: Anna
authors.initials: A
authors.lastname: Skaidas
authors.forename: Amit
authors.initials: A
authors.lastname: Roy
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Yang
authors.forename: Panos
authors.initials: P
authors.lastname: Georgapoulos
authors.forename: Joanna
authors.initials: J
authors.lastname: Burger
authors.forename: Keith
authors.initials: K
authors.lastname: Cooper
mesh_terms: D000818:Animals; D001822:Body Burden; D003198:Computer Simulation; D007700:Kinetics; D050356:Lipid Metabolism; D008954:Models, Biological; D010125:Ostreidae / Q000378:metabolism* / Q000502:physiology; D000072317:Polychlorinated Dibenzodioxins / Q000493:pharmacokinetics*; D014316:Tritium
chemical_list: D000072317:Polychlorinated Dibenzodioxins; D014316:Tritium