title: Activation of inflammation and coagulation after infusion of C-reactive protein in humans.
abstract: C-reactive protein (CRP) has been postulated to play a causal part in atherosclerosis and its acute complications. We assessed the effects of CRP-infusion on coagulation and inflammatory pathways to determine its role in atherothrombotic disease. Seven male volunteers received an infusion on two occasions, containing 1.25 mg/kg recombinant human CRP (rhCRP) or diluent, respectively. CRP-concentrations rose after rhCRP-infusion from 1.9 (0.3 to 8.5) to 23.9 (20.5 to 28.1) mg/L, and subsequently both inflammation and coagulation were activated. This sequence of events suggests that CRP is not only a well known marker of cardiovascular disease, but is also probably a mediator of atherothrombotic disease.
authors.affiliation: Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Radjesh J
authors.initials: RJ
authors.lastname: Bisoendial
authors.forename: John J P
authors.initials: JJ
authors.lastname: Kastelein
authors.forename: Johannes H M
authors.initials: JH
authors.lastname: Levels
authors.forename: Jaap J
authors.initials: JJ
authors.lastname: Zwaginga
authors.forename: Bas
authors.initials: B
authors.lastname: van den Bogaard
authors.forename: Pieter H
authors.initials: PH
authors.lastname: Reitsma
authors.forename: Joost C M
authors.initials: JC
authors.lastname: Meijers
authors.forename: Daniel
authors.initials: D
authors.lastname: Hartman
authors.forename: Marcel
authors.initials: M
authors.lastname: Levi
authors.forename: Erik S G
authors.initials: ES
authors.lastname: Stroes
mesh_terms: D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology*; D001777:Blood Coagulation / Q000187:drug effects*; D002097:C-Reactive Protein / Q000032:analysis / Q000633:toxicity*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000139:chemically induced*; D015850:Interleukin-6 / Q000097:blood; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011994:Recombinant Proteins / Q000633:toxicity
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D015850:Interleukin-6; D008070:Lipopolysaccharides; D017395:Plasminogen Activator Inhibitor 1; D011994:Recombinant Proteins; C036309:fibrin fragment D; D002097:C-Reactive Protein