title: [Relationship between plasma homocysteine and chronic complications in type 2 diabetes mellitus].
abstract: OBJECTIVE
  To assess the relationship between plasma homocysteine with chronic complications in type 2 diabetes mellitus.
  
  
  METHODS
  Plasma homocysteine levels, blood glucose, and HbA1c were measured in 60 diabetic patients (including 30 with and 30 without complications) and 31 normal subjects. The difference in the occurrence of chronic complications between patients with and without hyperhomocysteinemia was investigated.
  
  
  RESULTS
  Plasma homocysteine level was significantly higher in type 2 diabetic patients with chronic complication than in normal control subjects (P<0.01), and patients with chronic complications had higher homocysteine levels than those without chronic complications (P<0.01).
  
  
  CONCLUSIONS
  Hyperhomocysteinemia is related to chronic complication in 2 diabetes mellitus, possibly due to the injury to the vascular endothelium by homocysteine.
authors.affiliation: Department of Endocrinology, First Peoples' Hospital of Zhaoqing, Zhaoqing 526021, China. lwpzx@sina.com
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D048909:Diabetes Complications / Q000097:blood* / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications; D008297:Male; D008875:Middle Aged
chemical_list: D006710:Homocysteine