title: Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique.
abstract: The purpose of this research was to develop mouth dissolve tablets of nimesulide. Granules containing nimesulide, camphor, crospovidone, and lactose were prepared by wet granulation technique. Camphor was sublimed from the dried granules by exposure to vacuum. The porous granules were then compressed. Alternatively, tablets were first prepared and later exposed to vacuum. The tablets were evaluated for percentage friability, wetting time, and disintegration time. In the investigation, a 32 full factorial design was used to investigate the joint influence of 2 formulation variables: amount of camphor and crospovidone. The results of multiple linear regression analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using an optimum concentration of camphor and a higher percentage of crospovidone. A contour plot is also presented to graphically represent the effect of the independent variables on the disintegration time and percentage friability. A checkpoint batch was also prepared to prove the validity of the evolved mathematical model. Sublimation of camphor from tablets resulted in superior tablets as compared with the tablets prepared from granules that were exposed to vacuum. The systematic formulation approach helped in understanding the effect of formulation processing variables.
authors.affiliation: L.M. College of Pharmacy, Navrangpura, Ahmedabad-380 009, India. mukeshgohel@hotmail.com
authors.forename: Mukesh
authors.initials: M
authors.lastname: Gohel
authors.forename: Madhabhai
authors.initials: M
authors.lastname: Patel
authors.forename: Avani
authors.initials: A
authors.lastname: Amin
authors.forename: Ruchi
authors.initials: R
authors.lastname: Agrawal
authors.forename: Rikita
authors.initials: R
authors.lastname: Dave
authors.forename: Nehal
authors.initials: N
authors.lastname: Bariya
mesh_terms: D000284:Administration, Oral; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002164:Camphor / Q000737:chemistry; D003890:Desiccation / Q000379:methods; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D010592:Pharmaceutic Aids / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D011309:Preservation, Biological; D012995:Solubility; D013449:Sulfonamides / Q000008:administration & dosage / Q000737:chemistry*; D013607:Tablets; D013997:Time Factors; D014618:Vacuum
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010592:Pharmaceutic Aids; D013449:Sulfonamides; D013607:Tablets; D002164:Camphor; D011205:Povidone; C012655:nimesulide