Molecular actions of polyhalogenated arylhydrocarbons (PAHs) in female reproduction.
Polyhalogenated aromatic arylhydrocarbons (PAHs) such as polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), the polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are persistent lipophilic pollutants, which affect female fertility resulting in severe reproductive dysregulation, including anovulation, reduced conception rates, abortion, menstrual abnormalities and developmental defects of female reproductive tissues. Many PAHs exert their effects by activating a family of basic helix-loop-helix (bHLH) transcription factors, the arylhydrocarbon receptor (AhR) and the arylhydrocarbon receptor nuclear translocator (ARNT), which result in the expression of AhR target molecules. Complex interactions between PAH-mediated AhR activation and ER signalling pathways have been discovered which may contribute to the developmental malformations, impact on reproductive dysfunctions and promote carcinogenic dedifferentiation of tissues within the female reproductive tract. This review will focus on the multifaceted roles of PAHs in key organs of the female reproductive tract, the ovary, uterus/ endometrium and the mammary gland. The complexity and diversity of actions unleashed by PAHs in these female reproductive tissues identify these environmental pollutants as important endocrine disrupting toxicants impacting on female fertility.
Hombach-Klonisch
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Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Manitoba, R3E 0W3, Canada. klonisch@cc.umanitoba.ca
Pocar
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Kietz
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Klonisch
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D001572:Benzofurans / Q000633:toxicity; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants / Q000633:toxicity; D005260:Female; D005298:Fertility / Q000187:drug effects; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D042361:Mammary Glands, Human / Q000187:drug effects; D008954:Models, Biological; D010053:Ovary / Q000187:drug effects; D010647:Phenyl Ethers / Q000633:toxicity; D011075:Polybrominated Biphenyls / Q000633:toxicity; D011078:Polychlorinated Biphenyls / Q000633:toxicity; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000633:toxicity; D012098:Reproduction / Q000187:drug effects; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004785:Environmental Pollutants; D006846:Hydrocarbons, Halogenated; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls