title: Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode Caenorhabditis elegans.
abstract: The insulin/insulin-like growth factor-1 (Ins/IGF-1) pathway regulates the aging rate of the nematode Caenorhabditis elegans. We describe other features of the three Ins/IGF-1 mutants daf-2, age-1 and aap-1. We show that the investigated Ins/IGF-1 mutants all have a reduced body volume, reduced reproductive capacity, increased ATP concentrations and an elevated stress resistance. We also observed that heat production is lower in these mutants, although the respiration rate was similar or higher compared with wild-type individuals, suggesting a metabolic shift in these mutants.
authors.affiliation: Department of Biology, Ghent University, 9000 Ghent, Belgium.
authors.forename: Koen
authors.initials: K
authors.lastname: Houthoofd
authors.forename: Manuel A
authors.initials: MA
authors.lastname: Fidalgo
authors.forename: David
authors.initials: D
authors.lastname: Hoogewijs
authors.forename: Bart P
authors.initials: BP
authors.lastname: Braeckman
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lenaerts
authors.forename: Kristel
authors.initials: K
authors.lastname: Brys
authors.forename: Filip
authors.initials: F
authors.lastname: Matthijssens
authors.forename: Annemie
authors.initials: A
authors.lastname: De Vreese
authors.forename: Sylvie
authors.initials: S
authors.lastname: Van Eygen
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Muñoz
authors.forename: Jacques R
authors.initials: JR
authors.lastname: Vanfleteren
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000235:genetics / Q000502:physiology; D000818:Animals; D049628:Body Size; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D018869:Heat-Shock Response; D007328:Insulin / Q000235:genetics*; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D009154:Mutation; D010101:Oxygen Consumption; D012098:Reproduction
chemical_list: D007328:Insulin; D007334:Insulin-Like Growth Factor I; D000255:Adenosine Triphosphate