title: Repetitive profound thrombocytopenia after treatment with tirofiban: a case report.
abstract: The GPIIb/IIIa inhibitors are used in the acute coronary syndromes and interventional cardiology as antiplatelet agents. These drugs induce thrombocytopenia in approximately 1-5% of patients. Thrombocytopenia is rapid in onset and antibody mediated. Abciximab is associated with higher incidence of thrombocytopenia than eptifibatide and tirofiban. Profound thrombocytopenia has reportedly been an issue with abciximab, but not with tirofiban. We reported a case of acute profound thrombocytopenia due to on tirofiban treatment in the same patient at two different times.
authors.affiliation: Cardiology Department, Medical Faculty, Yüzüncü Yil University, Van, Turkey. drbeyhan@yahoo.com
authors.forename: Beyhan
authors.initials: B
authors.lastname: Eryonucu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Tuncer
authors.forename: Reha
authors.initials: R
authors.lastname: Erkoc
mesh_terms: D000800:Angioplasty, Balloon; D001157:Arterial Occlusive Diseases / Q000175:diagnosis; D001241:Aspirin / Q000627:therapeutic use; D000077144:Clopidogrel; D004334:Drug Administration Schedule; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000628:therapy; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D015607:Stents; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000453:epidemiology; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077466:Tirofiban; D014443:Tyrosine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D014443:Tyrosine; D000077144:Clopidogrel; D000077466:Tirofiban; D013988:Ticlopidine; D001241:Aspirin