A prospective study of a new immunochemical fecal occult blood test in Korean patients referred for colonoscopy.
OBJECTIVE
The exquisite performance characteristics of an immunochemical fecal occult blood test (IFOBT) are well understood. We evaluated the diagnostic validity of a new IFOBT for colorectal neoplasia in patients undergoing colonoscopy and compared its results with two other commercially available IFOBTs.


METHODS
Eighty-five consecutive patients referred for colonoscopy were studied. We performed three different IFOBTs, namely, HM-Jack, Instant-View, and a newly developed OcculTech on each fecal specimen.


RESULTS
OcculTech was easy to perform and had a sensitivity, specificity, and positive predictive value of 58.3%, 76.3%, and 27.9%, respectively, for the detection of colorectal cancers and >or=1 cm adenomas. OcculTech showed higher sensitivity than the automatic analyzer, HM-Jack. No improvement was obtained by combining tests.


CONCLUSIONS
The OcculTech test had performance characteristics comparable to the two other IFOBTs. This study confirms the usefulness of the OcculTech test for colorectal neoplasia screening.
Woo
Hee Yeon
HY
Department of Laboratory Medicine, Kangbuk Samsung Hospital and Sungkyunkwan University School of Medicine, #108 Pyeong-dong, Jongno-gu, Seoul, South Korea.
Mok
Rak Sun
RS
Park
Young Nam
YN
Park
Dong Il
DI
Sung
In Kyung
IK
Sohn
Chong Il
CI
Park
Hyosoon
H
D000236:Adenoma / Q000175:diagnosis; D000328:Adult; D000368:Aged; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007120:Immunochemistry / Q000379:methods*; D007723:Korea; D008297:Male; D008875:Middle Aged; D009780:Occult Blood; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012017:Referral and Consultation; D012680:Sensitivity and Specificity