The role of group 1 and group 2 CD1-restricted T cells in microbial immunity.
Group 1 and group 2 CD1 present both self and microbial lipid antigens to T cells. While group 1 CD1-restricted T cells are known for their ability to recognize mycobacterial glycolipid antigens, group 2 CD1-restricted T cells are recognized as regulatory T cells that can influence the outcome of innate and adaptive immune responses. The evidence that these T cells contribute to host defense against infectious diseases is reviewed.
Sköld
Markus
M
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith Building Room 516C, One Jimmy Fund Way, Boston, MA 02115, USA.
Behar
Samuel M
SM
D000818:Animals; D018949:Antigens, CD1 / Q000276:immunology*; D006801:Humans; D007239:Infections / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D018949:Antigens, CD1