Left ventricular function in children with sleep-disordered breathing.
Severe obstructive sleep apnea in children leads to congestive heart failure. We studied the early changes in left ventricular function across a range of severity of the disorder. A dose-dependent decrease in diastolic function with increased severity of obstructive apnea was demonstrated.
Amin
Raouf S
RS
Department of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. aminr@chmcc.org
Kimball
Thomas R
TR
Kalra
Maninder
M
Jeffries
Jenny L
JL
Carroll
John L
JL
Bean
Judy A
JA
Witt
Sandra A
SA
Glascock
Betty J
BJ
Daniels
Stephen R
SR
D000293:Adolescent; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002306:Cardiac Volume / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003971:Diastole / Q000502:physiology; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000503:physiopathology; D009200:Myocardial Contraction / Q000502:physiology; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D012016:Reference Values; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000503:physiopathology; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology
D010100:Oxygen