title: [T-cell lymphoma-leukemia caused by HTLV-1 in adults: two lymphomatous forms].
abstract: The adult T-cells lymphoma-leukemia is a serious complication by the HTLV-1 infection. It is a rarely described diseases in Africa, in spite of the frequency of the infection by this virus. We report two clinical observations of lymphomatous forms. The first observation concerned a 43 year old Senegalese woman, admitted for a deep alteration of her general status and peripheral polyadenopathies. The adenopathy biopsy set up the diagnosis of pleiomorph T lymphoma with great and medium cells. The HTLV-1 serology was positive. She had benefited of six polychemotherapy cures (cyclophosphamide, farmarubicine, oncovin, prednisone) within which she died in a cachectic presentation. The second observation concerned a 44 year old Senegalese man, admitted for peripheral polyadenopathies, ulcerated lesions of sole of the foot, and deep alteration of the general status. He presented a moderate hypercalcemia by 117 mg/l. The histological examination of a ganglionar biopsy concluded to a diffuse T lymphoma with great cells. The HTLV-1 serology was positive. The cutaneous lesions were due to a phaeohyphomycosis of Exophiala jeanselmei. The symptomatic therapeutic measures had been applied and he died within four weeks in a septicemic clinical manifestation. The adult T-cells lymphoma leukemia due to the HTLV-1 ought to be researched before any lymphomatous and leucemic manifestation by T-cells through a serological research. The prognostic stays very bad.
authors.affiliation: Service de médecine interne, Hôpital Principal, BP: 3006, Dakar, Sénégal. sara@refer.sn
authors.forename: S B
authors.initials: SB
authors.lastname: Gning
authors.forename: F
authors.initials: F
authors.lastname: Fall
authors.forename: K
authors.initials: K
authors.lastname: Ba-Fall
authors.forename: M
authors.initials: M
authors.lastname: Thiam
authors.forename: B
authors.initials: B
authors.lastname: Ndoye
authors.forename: P M
authors.initials: PM
authors.lastname: Gueye
authors.forename: P S
authors.initials: PS
authors.lastname: Mbaye
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis; D008297:Male