title: Alveolar ridge augmentation with a prototype trilayer membrane and various bone grafts: a histomorphometric study in baboons.
abstract: Barrier membranes have become a standard treatment option in alveolar ridge augmentation prior to implant placement. However, non-resorbable membranes require secondary surgery and resorbable membranes show an unfavorable degradation profile. The purpose of this study was to evaluate the potential of a slowly biodegradable/bioresorbable prototype trilayer membrane (PTLM) for supporting bone regeneration in alveolar ridge augmentation. Clinically relevant cavities were made 3 months after the extraction of the first and second molars in each jaw of six baboons. Each animal was treated with four different regimens: (1) autogenous bone block (ABB) alone, (2) ABB+PTLM, (3) deproteinized bovine bone mineral (DBBM)+PTLM and (4) no treatment. After 9 months, the baboons were sacrificed and block sections of the augmented area were subjected to histologic and histomorphometric analyses. Newly formed bone areas were determined at a distance of 1, 3, 7 and 10 mm from crestal. The data showed a well-preserved ridge profile at the membrane-protected sites, whereas non-protected bone blocks and control sites underwent severe resorption resulting in knife-edge ridge profiles. Significant differences were found between ABB+PTLM and ABB (P=0.0137-0.0232). DBBM+PTLM also produced a larger bone area compared with ABB alone (P=0.0396-0.0439). No significant difference in bone area was detectable between ABB+PTLM and DBBM+PTLM (P>0.05). The present study supports the use of the slowly biodegradable/bioresorbable PTLM with autografts and DBBM for lateral ridge augmentation in this type of bone defects.
authors.affiliation: Department of Oral Surgery, Vienna Medical University School of Dentistry, Ludwig Boltzmann Institute of Oral Implantology, Waehringerstrasse 25a, A-1090 Vienna, Austria. dieter.busenlechner@univie.ac.at
authors.forename: Dieter
authors.initials: D
authors.lastname: Busenlechner
authors.forename: Markus
authors.initials: M
authors.lastname: Kantor
authors.forename: Stefan
authors.initials: S
authors.lastname: Tangl
authors.forename: Gabor
authors.initials: G
authors.lastname: Tepper
authors.forename: Werner
authors.initials: W
authors.lastname: Zechner
authors.forename: Robert
authors.initials: R
authors.lastname: Haas
authors.forename: Georg
authors.initials: G
authors.lastname: Watzek
mesh_terms: D020341:Absorbable Implants; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D008297:Male; D008567:Membranes, Artificial; D010215:Papio
chemical_list: D018786:Bone Substitutes; D008567:Membranes, Artificial