Design and characterization of mucoadhesive buccal patches of salbutamol sulphate.
Mucoadhesive patches for delivery of salbutamol sulphate were prepared using polyvinyl alcohol, hydroxypropylmethyl cellulose and chitosan. Mechanical property, swelling and bioadhesive characteristics were detemined for both plain and medicated patches. Mechanical properties were determined in presence of carbopol and polyvinylpyrrolidone. The results showed an increase in swelling after addition of salbutamol sulphate to the plain formulation. This was attributed that the salbutamol sulphate modifies the way water is bound to or taken by the polymer. A decrease in residual time was observed for polyvinyl alcohol and citosan containing formula. High drug release was obtained from polyvinyl alcohol compared to the hydroxypropylmethylcellulose. Physical characteristics of the studied patches showed promising with good bioadhesion.
Panigrahi
Lalatendu
L
Sun Pharma Advance Research Center, Baroda-390 020, India. lalatendup@yahoo.com
Pattnaik
Snigdha
S
Ghosal
Saroj K
SK
D000268:Adhesiveness; D000278:Administration, Buccal; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D048271:Chitosan; D018592:Cross-Over Studies; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives*; D009061:Mouth Mucosa / Q000378:metabolism*; D011142:Polyvinyl Alcohol; D011817:Rabbits; D013718:Tensile Strength; D013997:Time Factors
D004337:Drug Carriers; D065347:Hypromellose Derivatives; D011142:Polyvinyl Alcohol; D008747:Methylcellulose; D048271:Chitosan; D000420:Albuterol