Cytokines and growth factors involved in peritoneal fibrosis of peritoneal dialysis patients.
Peritoneal fibrosis is initiated by exposure of peritoneal tissues to numerous harmful agents encountered during peritoneal dialysis. These agents interact with cells within the peritoneum to induce growth factors and cytokines that are important in the initiation, progression and maintenance of fibrosis. Some of the mediators implicated in the pathogenesis of peritoneal fibrosis include transforming growth factor (TGF) beta, connective tissue growth factor (CTGF), fibroblast growth factors (FGF), and platelet derived growth factor (PDGF).
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K-H
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Department of Medicine, McMaster University, Division of Nephrology, St Joseph's Hospital, 50 Charlton Ave E, Hamilton, Ontario, Canada L8P 4A6.
Margetts
P J
PJ
D055513:Connective Tissue Growth Factor; D016207:Cytokines / Q000378:metabolism*; D005355:Fibrosis; D006801:Humans; D017874:Immediate-Early Proteins / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010537:Peritoneum / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction
C526317:CCN2 protein, human; D016207:Cytokines; D017874:Immediate-Early Proteins; D036341:Intercellular Signaling Peptides and Proteins; D055513:Connective Tissue Growth Factor