Assessing prostate volume by magnetic resonance imaging: a comparison of different measurement approaches for organ volume analysis.
OBJECTIVE
We sought to evaluate the capabilities of different magnetic resonance imaging (MRI)-based methodologies for measuring prostate volume.


METHODS
Twenty-four male beagles with benign prostatic hyperplasia were enrolled in a drug trial and imaged at 5 time points. A total of 120 prostate volumes were determined by MRI-based semiautomated segmentation. For planimetric assessment, 8 diameter locations were determined in the axial and coronal plane of the MRI slice with maximum extension of the prostate. Thirteen calculation models based on these diameters were determined by comparison to the reference volume and evaluated during treatment.


RESULTS
The segmented MRI prostate volume significantly correlated with post necropsy volume. The best diameter-based model also worked very well for monitoring prostate volume of dogs under treatment.


CONCLUSIONS
MRI-based segmentation is highly accurate in assessing prostate volume. Diameter-based measurements are closely correlated to the segmented prostate volume and are feasible to monitor therapy.
Jia
Guang
G
Department of Radiology, The Ohio State University, Columbus, OH 43210, USA.
Baudendistel
Klaus T
KT
von Tengg-Kobligk
Hendrik
H
Heverhagen
Johannes T
JT
Polzer
Hans
H
Henry
Hannes
H
McAuliffe
Matthew J
MJ
Levine
Andrea L
AL
Rosol
Thomas J
TJ
Knopp
Michael V
MV
D000818:Animals; D004285:Dogs; D006965:Hyperplasia; D008279:Magnetic Resonance Imaging; D008297:Male; D008962:Models, Theoretical; D011467:Prostate / Q000033:anatomy & histology* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000175:diagnosis