Myelination in children with partial deletions of chromosome 18q.
OBJECTIVE
We compared myelin levels in white matter (WM) in typically developing children with those of children with partial deletions of chromosome 18q (18q-).


METHODS
Conventional spin-echo MR imaging at 1.9T was used to acquire T1-, T2-, and proton density-weighted images of the brain. From these images, a three-pool model was used to estimate the fraction of water in myelin, myelinated axon, and mixed water compartments (or pools) in six WM regions. A model curve was fit to the pool fractions to model the trend of myelin development by age in each region. Water-pool fractions in children with 18q- aged 5 months to 13 years were compared with those of age-matched, typically developing children.


RESULTS
In children with 18q-, the model predicted later onset of myelination (P <.02), lower myelination rates (P <.001), and smaller equilibrium myelin pool fractions (P <.001). Significant differences were seen between the two groups for all three water pool fractions (P <.001). The mixed pool fraction was larger in children with 18q-. Although the myelin pool fraction was significantly smaller, the myelinated axon pool fraction was only slightly smaller, leading to a significantly smaller estimate of myelin per myelinated axon in children with 18q- (P <.001).


CONCLUSIONS
Myelination modeling in 18q- children indicated delayed onset, a lower rate of myelination, and equilibrium myelin levels less than 50% those of age-matched, typically developing children.
Lancaster
Jack L
JL
Research Imaging Center, University of Texas Health Science Center at San Antonio, TX 78284, USA.
Cody
Jannine D
JD
Andrews
Trevor
T
Hardies
L Jean
LJ
Hale
Daniel E
DE
Fox
Peter T
PT
D001369:Axons / Q000473:pathology; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002887:Chromosomes, Human, Pair 18; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D009186:Myelin Sheath / Q000473:pathology*