[The prediction of high-risk patients for secondary hyperparathyroidism].
In patients with chronic renal failure (CRF), the degree of secondary hyperparathyroidism varies greatly. This may be explained, at least in part, by genetic differences. Some bone metabolism-related gene polymorphisms have been suggested to play a key role in the pathogenesis of secondary hyperparathyroidism in uremia. They are mainly associated with parathyroid hormone secretion and/or progression of parathyroid hyperplasia in patients with chronic renal failure, as well as in hemodialysis patients. Further studies might allow us the prediction of high-risk patients for this important complication.
Tahara
Hideki
H
Division of Metabolism, Endocrinology, and Molecular Medicine, Department of Internal Medicine, Osaka City University Graduate School of Medicine.