Syntheses of novel indole lipoic acid derivatives and their antioxidant effects on lipid peroxidation.
The aim of the study was to examine antioxidant properties of conjugates based on indole and lipoic acid moieties. The design and syntheses of novel indole alpha-lipoic acid derivatives were performed. The antioxidant properties of target compounds were investigated using rat liver microsomal, NADPH-dependent lipid peroxidation inhibition. Some of the target compounds, especially those containing amide linker at position 5 of indole ring, proved to be highly effective in inhibiting lipid peroxidation as compared to alpha-lipoic acid.
Gurkan
A Selen
AS
Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Turkey.
Karabay
Arzu
A
Buyukbingol
Zeliha
Z
Adejare
Adeboye
A
Buyukbingol
Erdem
E
D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
D000975:Antioxidants; D007211:Indoles; D008063:Thioctic Acid