Changes in expression of WT1 isoforms during induced differentiation of the NB4 cell line.
The levels of expression of WT1 gene and WT1+17AA isoforms rapidly decreased during the differentiation of NB4 cells induced by all-trans retinoic acid; this decrease was conversely related to the dynamic changes of CD11b positive cells, indicating that the abnormally high expression of WT1 gene and WT1+17AA isoforms was associated with a block of NB4 cell differentiation.
Gu
Weiying
W
Chen
Zixing
Z
Hu
Shaoyan
S
Shen
Huiling
H
Qiu
Guoqiang
G
Cao
Xiangshan
X
D002454:Cell Differentiation / Q000187:drug effects*; D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000473:pathology*; D020033:Protein Isoforms; D014212:Tretinoin / Q000494:pharmacology; D025721:WT1 Proteins / Q000032:analysis* / Q000235:genetics
D020033:Protein Isoforms; D025721:WT1 Proteins; D014212:Tretinoin