Atrial fibrillation device therapy considerations in design of clinical trials.
Management of atrial fibrillation is largely driven by the clinical status of the affected patient. Advances in understanding the mechanism of the arrhythmia have led to more aggressive catheter-based approaches to the management of atrial fibrillation. Because atrial fibrillation is a complex disease with multiple possible mechanisms, one approach for all patients is not feasible. Considerations regarding trial design and patient selection are discussed in this paper.
Celebi
Murat
M
Department of Medicine, Division of Cardiology, George Washington University Medical Center, 2150 Pennsylvania Avenue NW, Washington, DC 20037, USA.
Tracy
Cynthia M
CM
D001281:Atrial Fibrillation / Q000453:epidemiology / Q000628:therapy*; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods*; D002986:Clinical Trials as Topic / Q000379:methods*; D023381:Endpoint Determination; D006801:Humans; D018579:Patient Selection; D012107:Research Design