Hypoxia inducible factor-1 expression mediates myocardial response to ischemia late after acute myocardial infarction.
We report hypoxia-inducible factor-1 (HIF-1) expression in myocardium of patients with recent acute myocardial infarction (AMI), supporting the hypothesis of HIF-1 as a possible mediator of response to ischemia. A potential diagnostic role of determining tissue expression of HIF-1 as a marker of ischemia, and potential therapeutic implications by trying to modulate HIF-1 activity in order to promote beneficial effects of HIF-1 related genes (e.g. expression of vascular endothelial growth factor (VEGF)) may derive.
Parisi
Quintino
Q
Biondi-Zoccai
Giuseppe G L
GG
Abbate
Antonio
A
Santini
Daniele
D
Vasaturo
Fortunata
F
Scarpa
Susanna
S
Bussani
Rossana
R
Leone
Antonio Maria
AM
Petrolini
Alessandro
A
Silvestri
Furio
F
Biasucci
Luigi M
LM
Baldi
Alfonso
A
D000368:Aged; D000818:Animals; D002102:Cadaver; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D004195:Disease Models, Animal; D005260:Female; D015870:Gene Expression / Q000502:physiology*; D006801:Humans; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D009687:Nuclear Proteins / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis*
D004268:DNA-Binding Proteins; C497442:HIF1A protein, human; C497444:Hif1a protein, rat; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D014157:Transcription Factors