Cerebrospinal fluid HIV viral load in different phases of HIV-associated brain disease.
We compared CSF HIV viral load in 33 asymptomatic HIV seropositive patients, 11 patients with incipient minor motor deficits (MMD), 11 patients with sustained MMD, and 16 patients with HIV-associated dementia. Patients with incipient MMD showed significantly higher CSF viral load than asymptomatic patients. Demented patients also had higher CSF viral loads than asymptomatic patients. This phenomenon is independent of antiretroviral therapy. Thus, correlation of viral load with time suggests a multiphasic course of HIV-associated CNS disease.
von Giesen
Hans-Jürgen
HJ
Dept. of Neurology, Heinrich-Heine-Universität, Düsseldorf, Postfach 10 10 07, 40001 Düsseldorf, Germany. h-j.vgiesen@alexianer-krefeld.de
Adams
Ortwin
O
Köller
Hubertus
H
Arendt
Gabriele
G
D000328:Adult; D001927:Brain Diseases / Q000097:blood / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000503:physiopathology / Q000821:virology*; D005260:Female; D005385:Fingers / Q000503:physiopathology; D006678:HIV / Q000302:isolation & purification / Q000502:physiology; D015658:HIV Infections / Q000097:blood / Q000134:cerebrospinal fluid* / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D012367:RNA, Viral / Q000097:blood / Q000134:cerebrospinal fluid*; D012044:Regression Analysis; D013997:Time Factors; D019562:Viral Load
D012367:RNA, Viral