title: Nematicidal activity and chemical component of Poria cocos.
abstract: Poria cocos, a famous traditional Chinese medicine, was found to have nematicidal activity in experiments searching for nematicidal fungi. The experiment showed it could kill 94.9% of the saprophytic nematode, Panagrellus redivivue, 92.6% of the root-knot nematode, Meloidogyne arenaria, and 93.5% of the pine nematode, Bursaphelenchus xylophilus, on PDA plate within 12 hours. According to the nematicidal activity, three new compounds, 2, 4, 6-triacetylenic octane diacid, 2, 4, 5, 6-tetrahydroxyhexanoic acid and 3, 4-dihydroxy-2-keto-n-butyl 2,4,5,6-tetrahydroxyhexanate, were isolated from submerged cultures of Poria cocos. Of these, 2, 4, 6-triacetylenic octane diacid could kill 83.9% Meloidogyne arenaria and 73.4% Panagrellus redivivus at 500 ppm within 12 hours. Here, it is reported for the first time that Poria cocos has nematicidal activity.
authors.affiliation: Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, PR China.
authors.forename: Guo Hong
authors.initials: GH
authors.lastname: Li
authors.forename: Yue Mao
authors.initials: YM
authors.lastname: Shen
authors.forename: Ke Qin
authors.initials: KQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008516:Medicine, Chinese Traditional; D010935:Plant Diseases / Q000469:parasitology; D010944:Plants / Q000469:parasitology; D020072:Polyporales / Q000737:chemistry*; D017168:Rhabditida / Q000187:drug effects / Q000472:pathogenicity; D017187:Tylenchida / Q000187:drug effects / Q000472:pathogenicity; D014431:Tylenchoidea / Q000187:drug effects / Q000472:pathogenicity
chemical_list: D000969:Antinematodal Agents