title: Synthesis of latanoprost diastereoisomers.
abstract: A new synthesis of latanoprost diastereoisomers is described which utilizes a highly stereoselective Michael addition of higher-order cuprate to a chiral cyclopentenone derived from G-lactone in the crucial skeleton-forming step.
authors.affiliation: R&D Synthesis Group II, API Division, ZENTIVA VUFB, a.s., Prague, Czech Republic.
authors.forename: Iva
authors.initials: I
authors.lastname: Obadalová
authors.forename: Tomás
authors.initials: T
authors.lastname: Pilarcík
authors.forename: Markéta
authors.initials: M
authors.lastname: Slavíková
authors.forename: Josef
authors.initials: J
authors.lastname: Hájícek