Efficient synthesis of water-soluble calixarenes using click chemistry.
[reaction: see text] Several water-soluble calix[4]arenes were synthesized via Huisgen 1,3-dipolar cycloaddition between azides and alkynes. Cationic, anionic, and nonionic calixarenes were prepared from a common azidocalixarene intermediate. Azidocalixarenes performed better than alkynylcalixarenes as precursors. The aggregation behavior of the water-soluble calixarenes was studied by (1)H NMR spectroscopy.
Ryu
Eui-Hyun
EH
Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, USA.
Zhao
Yan
Y
D047250:Calixarenes / Q000138:chemical synthesis*; D002621:Chemistry / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012995:Solubility; D014867:Water / Q000737:chemistry
D014867:Water; D047250:Calixarenes