Anaplastic transformation from papillary thyroid carcinoma with increased serum CA19-9.
A 24-year-old woman presented with anaplastic transformation from papillary thyroid carcinoma with increased serum CA19-9. The patient had been diagnosed as having papillary thyroid carcinoma with lung metastasis at 11 years of age. She received a total thyroidectomy with cervical lymph node dissection followed by iodine-131 ((131)I) therapy over 12 years, but died due to sudden onset of rapid dissemination. Elevated serum CA19-9 was detected in the terminal stage, and anaplastic transformation was confirmed by post-mortem examination. Although there are few clinical reports suggesting a prognostic indicator for anaplastic thyroid carcinoma, CA19-9 may be a useful serum marker for this tumor.
Ogawa
Masahiro
M
Department of Pediatrics, Mie University School of Medicine, Tue, Mie 514-8507, Japan. ogwmshr@yahoo.co.jp
Hori
Hiroki
H
Hirayama
Masahiro
M
Kobayashi
Minako
M
Shiraishi
Taizou
T
Watanabe
Yuri
Y
Komada
Yoshihiro
Y
D000328:Adult; D000708:Anaplasia / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood*; D002277:Carcinoma / Q000097:blood* / Q000556:secondary; D002291:Carcinoma, Papillary / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D013964:Thyroid Neoplasms / Q000097:blood* / Q000473:pathology* / Q000556:secondary
D018395:CA-19-9 Antigen