title: United Arab Emirates National Newborn Screening Programme: an evaluation 1998-2000.
abstract: To evaluate the United Arab Emirate National Newborn Screening Programme we compared coverage, timeliness of programme indicators (age at sampling, recall and treatment initiation, timing of specimen delivery and laboratory results) and specimen quality with international standards. Recall rate, sensitivity, specificity, positive predictive values and relative incidence rates for phenylketonuria (PKU) and congenital hypothyroidism (CH) were calculated. Investigations for hypothyroidism included thyroid function studies (T3, T4, fT4 and TSH), technetium-99m thyroid scan when possible and thyroglobulin and thyroid antibodies when indicated. PKU investigations included plasma amino acids and measurement of biopterin defects. In the 6 years before December 2000, 138,718 neonates were screened. Relative incidences for CH and for classic PKU were 1:1570 and 1:20,050 respectively.
authors.affiliation: Central Department of Maternal and Child Health, Ministry of Health, Abu-Dhabi, United Arab Emirates.
authors.forename: H
authors.initials: H
authors.lastname: al-Hosani
authors.forename: M
authors.initials: M
authors.lastname: Salah
authors.forename: D
authors.initials: D
authors.lastname: Saade
authors.forename: H
authors.initials: H
authors.lastname: Osman
authors.forename: J
authors.initials: J
authors.lastname: al-Zahid
mesh_terms: D000359:Aftercare / Q000592:standards; D000367:Age Factors; D000596:Amino Acids / Q000097:blood; D001708:Biopterins / Q000097:blood; D001723:Birth Rate; D001800:Blood Specimen Collection / Q000592:standards; D003409:Congenital Hypothyroidism; D006301:Health Services Needs and Demand; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D015994:Incidence; D007231:Infant, Newborn; D015997:Neonatal Screening / Q000458:organization & administration*; D010661:Phenylketonurias / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D015397:Program Evaluation; D019984:Quality Indicators, Health Care / Q000592:standards; D012015:Reference Standards; D012680:Sensitivity and Specificity; D013667:Technetium; D013954:Thyroglobulin / Q000097:blood; D013960:Thyroid Function Tests; D013997:Time Factors; D014479:United Arab Emirates / Q000453:epidemiology
chemical_list: D000596:Amino Acids; D001708:Biopterins; D013667:Technetium; D013954:Thyroglobulin