title: The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria.
abstract: OBJECTIVE
  We assessed the disposition of oral amodiaquine (AQ) and CYP2C8 polymorphism in 20 children with falciparum malaria.
  
  
  METHODS
  AQ and DEAQ concentrations were determined with SPE-HPLC method. CYP2C8 genotypes were assessed by PCR-RFLP method.
  
  
  RESULTS
  AQ was not detectable beyond day 3 postdose. Cmax for DEAQ was reached in 3.0 days. The mean values for t1/2, MRT, and AUCtotal were 10.1 days, 15.5 days and 4512.6 microg l(-1) day, respectively. All the children were CYP2C8* homozygous.
  
  
  CONCLUSIONS
  Our data are consistent with those previously reported, and the AQ regimen seems pharmacokinetically adequate in the absence of CYP2C8 polymorphism.
authors.affiliation: School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea. hombanfr@upng.ac.pg
authors.forename: F W
authors.initials: FW
authors.lastname: Hombhanje
authors.forename: I
authors.initials: I
authors.lastname: Hwaihwanje
authors.forename: T
authors.initials: T
authors.lastname: Tsukahara
authors.forename: J
authors.initials: J
authors.lastname: Saruwatari
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: H
authors.initials: H
authors.lastname: Osawa
authors.forename: M M
authors.initials: MM
authors.lastname: Paniu
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: J K
authors.initials: JK
authors.lastname: Lum
authors.forename: B
authors.initials: B
authors.lastname: Aumora
authors.forename: A
authors.initials: A
authors.lastname: Masta
authors.forename: M
authors.initials: M
authors.lastname: Sapuri
authors.forename: T
authors.initials: T
authors.lastname: Kobayakawa
authors.forename: A
authors.initials: A
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Ishizaki
mesh_terms: D000284:Administration, Oral; D000655:Amodiaquine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000962:Antimalarials / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D065727:Cytochrome P-450 CYP2C8; D005838:Genotype; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000378:metabolism*; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D000962:Antimalarials; D000655:Amodiaquine; D001189:Aryl Hydrocarbon Hydroxylases; C450259:CYP2C8 protein, human; D065727:Cytochrome P-450 CYP2C8