title: Local excision of rectal cancer: review of literature.
abstract: In selected patients, local excision of rectal cancer may be an alternative to radical surgery such as abdominoperineal excision of the rectum or anterior resection. Local excision carries lower mortality and morbidity, without the functional disturbance or alteration in body image that can be associated with radical surgery. There are several techniques of local therapy for rectal cancer, with most experience being available in transanal excision. Transanal endoscopic microsurgery is also used but experience with this newer technique is limited. Patient selection is the most important factor in successful local excision, however specific criteria for selecting patients have not been universally accepted. Review of the published literature is difficult because of the variation in adjuvant therapy regimes and follow-up strategies, as well as results reported in terms of local recurrence and survival rates. There is increasing evidence to suggest that local excision should be restricted to patients with T1 stage rectal cancer without high-risk factors. The place for local excision in patients with T2 or high-risk T1 tumours requires prospective, randomised multi-centre trials comparing radical surgery with local excision, with or without adjuvant therapy.
authors.affiliation: University of Hull Academic Surgical Unit, Castle Hill Hospital, Cottingham, UK.
authors.forename: Piero
authors.initials: P
authors.lastname: Nastro
authors.forename: Daniel
authors.initials: D
authors.lastname: Beral
authors.forename: John
authors.initials: J
authors.lastname: Hartley
authors.forename: John R T
authors.initials: JR
authors.lastname: Monson
mesh_terms: D017024:Chemotherapy, Adjuvant; D003952:Diagnostic Imaging; D006801:Humans; D008866:Microsurgery; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009367:Neoplasm Staging; D018579:Patient Selection; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome