title: The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis.
abstract: This article reviews current concepts regarding the pathobiology of cystic fibrosis pancreatic disease. It summarizes recent studies on the relationship between CFTR mutations and pancreatitis, and it reviews several unresolved issues in the field.
authors.affiliation: Veterans Administration Medical Center, 508 Fulton Street, Durham, NC 27705, USA. cohn0001@mc.duke.edu
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Cohn
authors.forename: R Michael
authors.initials: RM
authors.lastname: Mitchell
authors.forename: Paul S
authors.initials: PS
authors.lastname: Jowell
mesh_terms: D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D010195:Pancreatitis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D012307:Risk Factors; D014359:Trypsin Inhibitor, Kazal Pancreatic
chemical_list: C505032:CFTR protein, human; D002352:Carrier Proteins; C486642:SPINK1 protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D014359:Trypsin Inhibitor, Kazal Pancreatic