title: Differential expression of vascular endothelial growth factor and its receptors in hematopoietic and fatty bone marrow: evidence that neuropilin-1 is produced by fat cells.
abstract: Vascular endothelial growth factor (VEGF), its receptors (VEGFR-1, VEGFR-2) and neuropillin-1 (NRP-1) are expressed at variable levels in bone marrow. NRP-1expression is higher in fatty bone marrow than in hematopoietic marrow. Adipocytes are responsible for NRP-1 expression suggesting that they may play a role in hematopoiesis by producing NRP-1 or that NRP-1 may regulate adipocyte activity.
authors.forename: Zakia
authors.initials: Z
authors.lastname: Belaid
authors.forename: Frederique
authors.initials: F
authors.lastname: Hubint
authors.forename: Chantal
authors.initials: C
authors.lastname: Humblet
authors.forename: Jacques
authors.initials: J
authors.lastname: Boniver
authors.forename: Betty
authors.initials: B
authors.lastname: Nusgens
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Defresne
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D001853:Bone Marrow; D005786:Gene Expression Regulation; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D039942:Neuropilin-1 / Q000096:biosynthesis*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D039942:Neuropilin-1; D040262:Receptors, Vascular Endothelial Growth Factor