A chiral cyclohexanone linked to polystyrene for solid-phase synthesis of chiral alpha-carbonyls.
Two chiral cyclohexanones were linked to polystyrene resin. The polymer-bound auxiliaries were subjected to a sequence of four reactions, the last of which cleaves the desired alpha-chiral carbonyl compound off the resin, concurrently regenerating the resin-bound auxiliary in its original form. The resin can then be reused.
Spino
Claude
C
Département of Chimie, Université of Sherbrooke, 2500 Boulevard Université, Sherbrooke, Qc, Canada, J1K 2R1. Claude.Spino@USherbrooke.ca
Gund
Vitthal Genbhau
VG
Nadeau
Christian
C
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003512:Cyclohexanones / Q000737:chemistry*; D008610:Menthol / Q000737:chemistry; D015394:Molecular Structure; D011137:Polystyrenes / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D000447:Aldehydes; D002264:Carboxylic Acids; D003512:Cyclohexanones; D011137:Polystyrenes; D008610:Menthol; C036468:cyclohexanone; C019466:menthone