title: Do oestrogen receptors play a role in the pathogenesis of HIV-associated lipodystrophy?
abstract: Epidemiological data show an increased risk of HIV-associated lipodystrophy in women, and sex hormone abnormalities have been reported with highly active antiretroviral therapy (HAART). This study, which demonstrates that oestrogen receptor beta expression is significantly reduced in the subcutaneous adipose tissue of HIV-infected lipodystrophic patients, downregulated by HAART regimens including protease inhibitors (PI), and restored after switching from PI, opens perspectives for the investigation of selective oestrogen receptor modifiers for the management of this syndrome.
authors.affiliation: Departments of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Barzon
authors.forename: Mauro
authors.initials: M
authors.lastname: Zamboni
authors.forename: Monia
authors.initials: M
authors.lastname: Pacenti
authors.forename: Gabriella
authors.initials: G
authors.lastname: Milan
authors.forename: Ottavio
authors.initials: O
authors.lastname: Bosello
authors.forename: Giovanni
authors.initials: G
authors.lastname: Federspil
authors.forename: Giorgio
authors.initials: G
authors.lastname: Palù
authors.forename: Roberto
authors.initials: R
authors.lastname: Vettor
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D001824:Body Constitution / Q000502:physiology; D015536:Down-Regulation / Q000235:genetics; D047629:Estrogen Receptor beta / Q000032:analysis; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D039682:HIV-Associated Lipodystrophy Syndrome / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*
chemical_list: D047629:Estrogen Receptor beta; D017320:HIV Protease Inhibitors; D011960:Receptors, Estrogen