title: Enantioselective enol lactone synthesis under double catalytic conditions.
abstract: [reaction: see text] The reaction of dimedone with 1-(2-alkenoyl)-4-bromo-3,5-dimethylpyrazoles in THF, catalyzed by catalytic amounts of both DBFOX/Ph-nickel(II) perchlorate trihydrate and 2,2,6,6-tetramethylpiperidine, in the presence of acetic anhydride in THF produces the corresponding enol lactones in high enantioselectivities through enantioselective Michael additions followed by cyclization with removal of the pyrazole auxiliary. Other related nucleophile precursors can be successfully applied in the enantioselective enol lactone synthesis under the double catalytic conditions.
authors.affiliation: Institute for Materials Chemistry and Engineering, CREST of JST (Japan Science and Technology Agency), Kyushu University, 6-1 Kasugakoen, Kasuga 816-8580, Japan.
authors.forename: Kennosuke
authors.initials: K
authors.lastname: Itoh
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Junji
authors.initials: J
authors.lastname: Tanaka
authors.forename: Shuji
authors.initials: S
authors.lastname: Kanemasa