Atopic disease in childhood.
A child with atopy produces IgE antibodies after exposure to common environmental allergens. The atopic diseases (eczema, asthma and rhinoconjunctivitis) are clinical syndromes each defined by a group of symptoms and signs. Not all children with atopy will have atopic disease or develop symptoms after exposure to an allergen. Both genetic and environmental factors determine the development of atopic disease. The presence of specific IgE antibodies to environmental allergens is determined with skin prick or radioallergosorbent testing in children with atopy. Test results should be interpreted in the context of the clinical history and further investigations (eg, allergen avoidance or challenge). Management of atopic disease is frequently symptomatic, but it is important to avoid identified allergen triggers. Immunotherapy may be considered in selected school-age children with severe rhinoconjunctivitis. Preventing atopic disease in high-risk infants and hindering progression of disease in children with established disease are the areas of active research.
Gold
Michael S
MS
Department of Paediatrics, Adelaide University, Women's and Children's Hospital, North Adelaide, Adelaide, SA 5000, Australia. michael.gold@adelaide.edu.au
Kemp
Andrew S
AS
D000485:Allergens; D001249:Asthma / Q000175:diagnosis / Q000628:therapy; D002648:Child; D003233:Conjunctivitis, Allergic / Q000175:diagnosis / Q000628:therapy; D004485:Eczema / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D004781:Environmental Exposure / Q000517:prevention & control; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000517:prevention & control; D020022:Genetic Predisposition to Disease; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D007167:Immunotherapy / Q000379:methods; D007223:Infant; D008297:Male; D012220:Rhinitis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D012307:Risk Factors; D012882:Skin Tests / Q000379:methods
D000485:Allergens