Bone morphogenetic proteins: basic concepts.
The cellular and molecular events governing bone formation in the embryo, healing of a fractured bone, and induced bone fusion follow a similar pattern. Discovery, purification, and recombinant synthesis of bone morphogenetic proteins (BMPs) constitute a major milestone in the understanding of bone physiology. In this review the author discusses the mechanism of action, clinical applications, dosage, and optimum carriers for BMPs. The roles played by other growth factors are also discussed.
Rengachary
Setti S
SS
Department of Neurosurgery, Wayne State University School of Medicine, Detroit Medical Center, Detroit, Michigan, USA. srengachary@neurosurgery.wayne.edu
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage* / Q000145:classification / Q000502:physiology*; D050723:Fractures, Bone / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D019485:Bone Morphogenetic Proteins