title: Homing in on intracellular Abeta?
abstract: In this issue of Neuron, a study by Billings et al. points to intracellular Abeta as a possible cause of neuronal dysfunction. In a mouse model of Alzheimer's disease, Billings et al. link appearance of intraneuronal Abeta to cognitive impairments and then show that "clearance" of intraneuronal Abeta by anti-Abeta antibodies restores cognitive deficits.
authors.affiliation: Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
authors.forename: Todd E
authors.initials: TE
authors.lastname: Golde
authors.forename: Christopher
authors.initials: C
authors.lastname: Janus
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007424:Intracellular Fluid / Q000737:chemistry / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides