title: Current strategies in diagnostics and endocrine treatment of patients with childhood craniopharyngioma during follow-up--recommendations in KRANIOPHARYNGEOM 2000.
abstract: Craniopharyngiomas are rare dysontogenetic malformations. As the survival rate after craniopharyngioma diagnosed during childhood and adolescence is high, prognosis and quality of life (QoL) in survivors mainly depend on adverse late effects such as hypopituitarism and obesity. Appropriate laboratory diagnostics of endocrine deficiencies and sufficient hormonal substitution have significant impact on prognosis and QoL. In order to evaluate and standardize diagnostic and therapeutical strategies in childhood craniopharyngioma the prospective multicenter surveillance study KRANIOPHARYNGEOM 2000 was initiated for patients diagnosed with craniopharyngioma during childhood and adolescence. We are reporting on current strategies for laboratory diagnostics and endocrine substitution in patients with childhood craniopharyngioma recruited in KRANIOPHARYNGEOM 2000.
authors.affiliation: Klinik für Allgemeine Kinderheilkunde, Hämatologie / Onkologie, Zentrum für Kinder- und Jugendmedizin, Klinikum Oldenburg, Germany. mueller.hermann@klinikum-oldenburg.de
authors.forename: Hermann L
authors.initials: HL
authors.lastname: Müller
authors.forename: Ursel
authors.initials: U
authors.lastname: Gebhardt
authors.forename: Nicole
authors.initials: N
authors.lastname: Etavard-Gorris
authors.forename: Reinhard
authors.initials: R
authors.lastname: Kolb
authors.forename: Monika
authors.initials: M
authors.lastname: Warmuth-Metz
authors.forename: Niels
authors.initials: N
authors.lastname: Sörensen
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003397:Craniopharyngioma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D020790:Diabetes Insipidus, Neurogenic / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D005260:Female; D005858:Germany; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009765:Obesity / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D016896:Treatment Outcome