title: Polymethacrylate-based nitric oxide donors with pendant N-diazeniumdiolated alkyldiamine moieties: synthesis, characterization, and preparation of nitric oxide releasing polymeric coatings.
abstract: A series of new nitric oxide (NO) releasing copolymers have been prepared by covalently anchoring alkyldiamine side chains onto a polymethacrylate-based polymer backbone, followed by NO addition to form the desired pendant diazeniumdiolate structures. The resulting diazeniumdiolated copolymers were characterized via UV spectroscopy, and their proton-driven decomposition to release NO was also examined by UV and FTIR as well as chemiluminescence. Polymers with up to 22.1 mol % of incorporated amine sites that can be converted to corresponding diazeniumdiolates could be prepared, and such polymers release up to 0.94 micromol/mg of NO. Further, novel NO releasing polymeric coatings were formulated by doping one of the new polymethacrylate-based NO donors within inert polymeric matrixes. Biodegradable poly(lactide-co-glycolide) was employed as a film additive to greatly prolong the NO release of such coatings by continuously generating protons within the organic phase of the polymeric films, thereby driving decomposition of the diazeniumdiolates.
authors.affiliation: Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Zhou
authors.forename: Mark E
authors.initials: ME
authors.lastname: Meyerhoff
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis*; D003959:Diamines / Q000737:chemistry*; D007700:Kinetics; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D001391:Azo Compounds; D020099:Coated Materials, Biocompatible; D003959:Diamines; D020030:Nitric Oxide Donors; D011108:Polymers; D011109:Polymethacrylic Acids; C452539:diazeniumdiolate; C030613:polymethacrylic acid