title: Macrophage colony-stimulating factor (M-CSF), as well as granulocyte colony-stimulating factor (G-CSF), accelerates neovascularization.
abstract: It has been reported that bone marrow cells (BMCs) differentiate into endothelial cells of blood vessels, and that granulocyte colony-stimulating factor (G-CSF) mobilizes progenitors in the BMCs to the peripheral blood, while macrophage colony-stimulating factor (M-CSF) augments the production of monocytes. We examined whether M-CSF augments the differentiation of BMCs into endothelial cells of blood vessels using a hindlimb-ischemic model. Either G-CSF or M-CSF, or both, was administered to the hindlimb-ischemic mice for 3 days. Both M-CSF and G-CSF augmented the differentiation of BMCs into endothelial cells of blood vessels through vascular endothelial cell growth factor (VEGF), resulting in early recovery of blood flow in the ischemic limbs.
authors.affiliation: First Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570-8507, Japan.
authors.forename: Keizo
authors.initials: K
authors.lastname: Minamino
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Adachi
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Okigaki
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Ito
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Togawa
authors.forename: Kengo
authors.initials: K
authors.lastname: Fujita
authors.forename: Minoru
authors.initials: M
authors.lastname: Tomita
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yuming
authors.initials: Y
authors.lastname: Zhang
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Keiji
authors.initials: K
authors.lastname: Nakano
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Koike
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsubara
authors.forename: Toshiji
authors.initials: T
authors.lastname: Iwasaka
authors.forename: Miyo
authors.initials: M
authors.lastname: Matsumura
authors.forename: Susumu
authors.initials: S
authors.lastname: Ikehara
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D004727:Endothelium / Q000737:chemistry; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D006183:H-2 Antigens / Q000032:analysis; D006614:Hindlimb / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D007511:Ischemia / Q000503:physiopathology; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D059630:Mesenchymal Stem Cells / Q000166:cytology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018482:Muscle, Skeletal / Q000098:blood supply; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D006183:H-2 Antigens; D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse; D016179:Granulocyte Colony-Stimulating Factor; D049452:Green Fluorescent Proteins; D016173:Macrophage Colony-Stimulating Factor