title: [Functional continuum of the regulatory peptides enhancing anxiety. Search for the optimal complexes as a basis for developing inhibitory therapeutic agents].
abstract: Regulatory peptides (RP) take an active part in managing the majority of physiological processes. One of these functional applications is the monitoring of the anxiety level, of panic state. This work represents the presumptive analysis of literature data of 1960-2004 on the effects of regulatory peptides enhancing anxiety (RP-AT). This information database was used for researching the characteristics of organization and functionality of the system of anxiogenic RP. Taking into account the method of vector representation of RP effects, estimation of spectra of physiological effects that can go with each of RP-AT and their combination, was carried out. The most perspective RP complexes of anxiogenic profile for further experimental development of inhibitory therapeutic agents are proposed.
authors.forename: S V
authors.initials: SV
authors.lastname: Koroleva
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D004347:Drug Interactions; D005239:Fear / Q000187:drug effects; D006801:Humans; D007114:Immunization; D018716:Molecular Mimicry; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors / Q000502:physiology* / Q000627:therapeutic use*; D010455:Peptides / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*
chemical_list: D014151:Anti-Anxiety Agents; D018377:Neurotransmitter Agents; D010455:Peptides