Repetitive transcranial magnetic stimulation induces kf-1 expression in the rat brain.
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive approach used for stimulating the brain, and has proven effective in the treatment of depression, however the mechanism of its antidepressant action is unknown. Recently, we have reported the induction of kf-1 in rat frontal cortex and hippocampus after chronic antidepressant treatment and repeated electroconvulsive treatment (ECT). In this study, we demonstrated the induction of kf-1 after rTMS in the rat frontal cortex and hippocampus, but not in hypothalamus. Our data suggest that kf-1 may be a common functional molecule that is increased after antidepressant treatment, ECT and rTMS. In conclusion, it is proposed that induction of kf-1 may be associated with the treatment induced adaptive neural plasticity in the brain, which is a long-term target for their antidepressant action.
Kudo
Kentaro
K
Department of Psychiatry, Showa University School of Medicine, Tokyo 142-8666, Japan.
Yamada
Misa
M
Takahashi
Kou
K
Nishioka
Gentaro
G
Tanaka
Satoshi
S
Hashiguchi
Tomo
T
Fukuzako
Hiroshi
H
Takigawa
Morikuni
M
Higuchi
Teruhiko
T
Momose
Kazutaka
K
Kamijima
Kunitoshi
K
Yamada
Mitsuhiko
M
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D015152:Blotting, Northern; D017931:DNA Primers; D005625:Frontal Lobe / Q000378:metabolism*; D015870:Gene Expression; D006220:Haloperidol / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000187:drug effects; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050781:Transcranial Magnetic Stimulation
D000928:Antidepressive Agents; D017931:DNA Primers; D009419:Nerve Tissue Proteins; C484500:Rnf103 protein, rat; D006220:Haloperidol