Combinatorial chemistry in glycobiology.
The application of combinatorial chemistry to glycobiology historically has proven challenging due to numerous synthetic hurdles. The advent of novel methodologies has enabled the production of natural as well as mimetic analogues for proof-of-concept experiments and SAR. This review highlights some of the recent synthetic advances in combinatorial carbohydrate synthesis. The application of carbohydrate libraries in glycobiology is also discussed.
Plante
Obadiah J
OJ
Ancora Pharmaceuticals Inc., 200 Boston Ave, Suite 4975, Medford, MA 02155, USA. oplante@ancorapharma.com
D001695:Biology; D002241:Carbohydrates / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D006001:Glycoconjugates; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013329:Structure-Activity Relationship
D002241:Carbohydrates; D006001:Glycoconjugates; D004364:Pharmaceutical Preparations