title: Transepithelial phototherapeutic keratectomy/photorefractive keratectomy with adjunctive mitomycin-C for complicated LASIK flaps.
abstract: OBJECTIVE
  To evaluate the efficacy of transepithelial phototherapeutic keratectomy/photorefractive keratectomy (PTK/PRK) with prophylactic mitomycin-C for the treatment of refractive errors and maintenance of corneal clarity following flap complications in laser in situ keratomileusis (LASIK).
  
  
  METHODS
  Outpatient tertiary care center, Chicago, Illinois, USA.
  
  
  METHODS
  Ten eyes of 10 patients with LASIK flap complications had transepithelial PTK/PRK for correction of ametropia. Mitomycin-C 0.02% was applied to the stroma for 2 minutes following laser ablation. Postoperative uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), refractions, and slitlamp examinations were obtained.
  
  
  RESULTS
  Preoperatively, the mean UCVA was 20/400 (range 20/40 to counting fingers), the mean BSCVA was 20/28.5, and the spherical equivalent refractive errors ranged from +4.00 to -10.75 diopters (D). After the procedure, the mean UCVA was 20/28, the mean BSCVA was 20/21, and the spherical equivalent refractive errors ranged from +0.37 to -1.00 D. The mean follow-up ranged from 8 to 28 months. No patient experienced delayed reepithelialization, haze, or other signs of toxicity.
  
  
  CONCLUSIONS
  Mitomycin-C can be a useful adjunctive therapy for the prevention of haze when applying surface excimer laser therapy to a cornea following LASIK flap complications.
authors.affiliation: Cornea Service, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA.
authors.forename: Laura T
authors.initials: LT
authors.lastname: Muller
authors.forename: Eugenio M
authors.initials: EM
authors.lastname: Candal
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Epstein
authors.forename: Richard F
authors.initials: RF
authors.lastname: Dennis
authors.forename: Parag A
authors.initials: PA
authors.lastname: Majmudar
mesh_terms: D000328:Adult; D000477:Alkylating Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003319:Corneal Stroma / Q000187:drug effects* / Q000601:surgery*; D004847:Epithelial Cells; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D020731:Keratomileusis, Laser In Situ; D054018:Lasers, Excimer; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D018903:Photorefractive Keratectomy / Q000379:methods*; D013524:Surgical Flaps; D014792:Visual Acuity
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin