[Estriol replacement therapy in osteoporotic women].
In cultured human osteoblast-like cells (HOS), combined treatment with estriol (E(3)) and vitamin D(3) (VD(3)) increases the cell viability relative to treatment with E(3) alone and that E(3) treatment remarkably increases VD(3) receptor mRNA expression in the cells. Our findings in the present study with osteoblast cells may explain at least in a part the molecular basis of the clinical efficacy of combined treatment with E(3) and VD(3) in osteoporotic women.
Matsuo
Hiroya
H
Department of Health Sciences, Kobe University School of Medicine.