Evaluation of extended-release diltiazem once daily for cats with hypertrophic cardiomyopathy.
Serum diltiazem concentrations were evaluated following either 30 mg or 60 mg of an extended-release diltiazem administered orally once daily to 13 cats. Sequential blood samples were obtained over 24 hours. Both dosages usually resulted in elevated serum concentrations of >200 ng/mL at 6, 12, 18, and 24 hours. The 30-mg dosage was sometimes associated with low serum concentrations of <50 ng/mL at 18 and 24 hours. The 60-mg dosage (9.3 to 14.8 mg/kg) was associated with lethargy, gastrointestinal disturbances, and weight loss in nine (36%) of 25 client-owned cats. Gastrointestinal disturbances were recognized within 1 week, and weight loss was detected after 2 to 6 months of treatment.
Wall
Michelle
M
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA.
Calvert
Clay A
CA
Sanderson
Sherry L
SL
Leonhardt
Andrea
A
Barker
Corrie
C
Fallaw
Tiffany K
TK
D000818:Animals; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D002317:Cardiovascular Agents / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D002371:Cat Diseases / Q000097:blood / Q000188:drug therapy*; D002415:Cats; D004110:Diltiazem / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D016896:Treatment Outcome
D002317:Cardiovascular Agents; D004110:Diltiazem