title: Bacterial zoonoses and infective endocarditis, Algeria.
abstract: Blood culture-negative endocarditis is common in Algeria. We describe the etiology of infective endocarditis in this country. Samples from 110 cases in 108 patients were collected in Algiers. Blood cultures were performed in Algeria. Serologic and molecular analysis of valves was performed in France. Infective endocarditis was classified as definite in 77 cases and possible in 33. Causative agents were detected by blood cultures in 48 cases. All 62 blood culture-negative endocarditis cases were tested by serologic or molecular methods or both. Of these, 34 tested negative and 28 had an etiologic agent identified. A total of 18 infective endocarditis cases were caused by zoonotic and arthropodborne bacteria, including Bartonella quintana (14 cases), Brucella melitensis (2 cases), and Coxiella burnetii (2 cases). Our data underline the high prevalence of infective endocarditis caused by Bartonella quintana in northern Africa and the role of serologic and molecular tools for the diagnosis of blood culture-negative endocarditis.
authors.affiliation: Service de Biologie Clinique, Alger, Algérie.
authors.forename: Akila
authors.initials: A
authors.lastname: Benslimani
authors.forename: Florence
authors.initials: F
authors.lastname: Fenollar
authors.forename: Hubert
authors.initials: H
authors.lastname: Lepidi
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000462:Algeria; D000907:Antibodies, Bacterial / Q000097:blood; D018413:Bartonella quintana / Q000235:genetics / Q000302:isolation & purification*; D017347:Brucella melitensis / Q000235:genetics / Q000302:isolation & purification*; D002648:Child; D016997:Coxiella burnetii / Q000235:genetics / Q000302:isolation & purification*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004697:Endocarditis, Bacterial / Q000097:blood / Q000382:microbiology*; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006351:Heart Valves / Q000382:microbiology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012335:RNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D012424:Rural Population; D014505:Urban Population; D015047:Zoonoses / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D012335:RNA, Ribosomal