title: The immunoepidemiology of human hookworm infection.
abstract: Advances in hookworm immunoepidemiology are reviewed. Recent studies demonstrate a mixed Th1/Th2 response in human hookworm infection, with immunosuppression of specific and nonspecific IFN-gamma responses. There is increasing evidence for protective immunity in human hookworm infection, including anti-larval IL-5- and IgE-dependent mechanisms, and for immunological interactions between hookworm infection and other diseases.
authors.affiliation: School of Biology, University of Leeds, Leeds LS2 9JT, UK. r.j.quinnell@leeds.ac.uk
authors.forename: R J
authors.initials: RJ
authors.lastname: Quinnell
authors.forename: J
authors.initials: J
authors.lastname: Bethony
authors.forename: D I
authors.initials: DI
authors.lastname: Pritchard
mesh_terms: D000722:Ancylostoma / Q000276:immunology* / Q000472:pathogenicity; D000724:Ancylostomiasis / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology; D000818:Animals; D006725:Hookworm Infections / Q000453:epidemiology* / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D017221:Necator americanus / Q000276:immunology* / Q000472:pathogenicity; D009332:Necatoriasis / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology