[Acute biocompatibility of hemodiafiltration with endogenous reinfusion (HFR)].
OBJECTIVE
In order to reduce the hemodialysis (HD)-induced pro-inflammatory activity we need to use a biocompatible dialysis membrane, avoid backfiltration and possibly use adsorbents. Hemodiafiltration reinfusion (HFR) is a new on-line hemodiafiltration (HDF) technique combining these aspects. This study aimed to evaluate the biocompatibility of the single dialysis session comparing standard HD and HFR.


METHODS
Eighteen patients on chronic HD were enrolled in five Centers. Patients underwent one standard and two HFR study sessions; in each session we evaluated leukocyte activation at 0, 5, 15, 60 and 240 min; and interleukin-6 (IL-6), C-reactive protein (CRP) and IL-1 receptor antagonist (IL-1Ra) levels at 0, 60 and 240 min.


RESULTS
Leukocyte activation was similar in HD and HFR, while the post-dialysis IL-6 increase was lower with HFR; CRP levels were stable during HFR, but increased after HD, and IL-1Ra did not demonstrate any difference.


CONCLUSIONS
These preliminary data show that HFR still has a better biocompatibility in the single dialysis session.
Aucella
F
F
U.O. di Nefrologia e Dialisi, Ospedale Casa Sollievo della Sofferenza IRCCS, San Giovanni Rotondo, Foggia. faucel@tin.it
Gesuete
A
A
Sereni
L
L
Netti
S
S
Savastano
A M
AM
Querques
M
M
Specchio
A
A
De Min
A
A
Avanzi
C
C
Montemurno
C
C
Grandone
E
E
Cappucci
F
F
Procaccini
D A
DA
Stallone
C
C
Gesualdo
L
L
D017583:Hemodiafiltration / Q000379:methods*; D015312:Hemodialysis Solutions / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D014511:Uremia / Q000628:therapy*
D015312:Hemodialysis Solutions