title: The strictured anastomosis: successful treatment by corticosteroid injections--report of three cases and review of the literature.
abstract: Clinically significant anastomotic strictures usually only occur with very low colorectal anastomoses below the level of the peritoneal reflection. The reported rate averages 8 percent and has been attributed to tissue ischemia, localized sepsis, anastomotic leak, proximal fecal diversion, radiation injury, inflammatory bowel disease, and recurrent rectal cancer. Most patients will have symptoms of obstipation, frequent small bowel movements, and bloating. Symptomatic strictures are often approached by dilation (balloon or Hegar) or less often repeat resection. Many of these patients have anastomoses that are too low to consider repeat resection. Strictureplasty with linear stapling devices, stricture resection by use of the circular stapling device, and repeat dilations have all been described. Steroid injections into the stricture have been described in strictured esophagogastric anastomoses but have not been commonly used for strictured coloproctostomies. We describe three cases of coloanal stricture following resections that were complicated by postoperative pelvic abcesses, anastomatic leaks, and pelvic fibrosis. Two cases had undergone low coloanal anastomosis that was protected by a loop ileostomy and developed as significant stricture in the early postoperative period. The third case was managed without a protective loop ileostomy. These were initially managed by repeated dilation of the anastomosis. Each episode was followed by rapid recurrence of the stricture. All patients underwent subsequent dilation with injection of 40 mg of triamcinolone acetate (divided dose in four quadrants) into the stricture and subsequent complete resolution of the stricture. Those patients with loop ileostomies had them taken down and all have been followed for up to 12 months without clinical or endoscopic evidence of recurrent stricture.
authors.affiliation: Department of General Surgery, Naval Medical Center, Portsmouth, Virginia 23708-2197, USA. PALucha@mar.med.navy.mil
authors.forename: Paul A
authors.initials: PA
authors.lastname: Lucha
authors.forename: James E
authors.initials: JE
authors.lastname: Fticsar
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Francis
mesh_terms: D000038:Abscess / Q000209:etiology; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000714:Anastomosis, Surgical / Q000009:adverse effects; D001004:Anus Diseases / Q000473:pathology / Q000601:surgery*; D003108:Colonic Diseases / Q000473:pathology / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000601:surgery; D003251:Constriction, Pathologic / Q000209:etiology; D004106:Dilatation; D005260:Female; D005355:Fibrosis / Q000209:etiology; D006801:Humans; D007081:Ileostomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones