[Utility of biochemical markers of bone turnover in the assessment of osteoporosis].
Osteoporosis is characterized by both an imbalance between resorption and formation within the remodeling unit, and by an abnormalities of activation frequency, bone turnover. Bone mineral density (BMD) measurement is critical in the clinical evaluation of the patient at risk for osteoporosis, but it represents a static parameter that provides no insight into the rate of bone turnover in a given patient. The recent availability of biochemical markers for bone turnover are a major methodological advance. These measurements are noninvasive, and very useful in assessing turnover abnormalities of various osteoporotic states and in monitoring effects of treatment.
Kishimoto
H
H
Department of Orthopedic Surgery, Sanin Rosai Hospital.