Small RNAs: classification, biogenesis, and function.
Eukaryotes produce various types of small RNAs of 19-28 nt in length. With rapidly increasing numbers of small RNAs listed in recent years, we have come to realize how widespread their functions are and how diverse the biogenesis pathways have evolved. At the same time, we are beginning to grasp the common features and rules governing the key steps in small RNA pathways. In this review, I will summarize the current classification, biogenesis, action mechanism and function of these fascinating molecules.
Kim
V Narry
VN
Department of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151-742, Korea. narrykim@snu.ac.kr
D000818:Animals; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000145:classification / Q000502:physiology; D010944:Plants / Q000235:genetics; D034622:RNA Interference; D012330:RNA, Double-Stranded / Q000378:metabolism; D034741:RNA, Small Interfering / Q000145:classification / Q000502:physiology; D022661:RNA, Untranslated / Q000145:classification / Q000502:physiology; D043244:Ribonuclease III / Q000378:metabolism / Q000502:physiology
D029742:Caenorhabditis elegans Proteins; D035683:MicroRNAs; D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering; D022661:RNA, Untranslated; C517918:DROSHA protein, human; D043244:Ribonuclease III; C493336:drsh-1 protein, C elegans