title: Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents.
abstract: Gold nanocages of <40 nm in dimension have been synthesized using the galvanic replacement reaction between Ag nanocubes and HAuCl4 in an aqueous solution. By controlling the molar ratio between Ag and HAuCl4, the gold nanocages could be tuned to display surface plasmon resonance peaks around 800 nm, a wavelength commonly used in optical coherence tomography (OCT) imaging. OCT measurements on phantom samples indicate that these gold nanocages have a moderate scattering cross-section of approximately 8.10 x 10(-16) m2 but a very large absorption cross-section of approximately 7.26 x 10(-15) m2, suggesting their potential use as a new class of contrast agents for optical imaging. When bioconjugated with antibodies, the gold nanocages have also been demonstrated for specific targeting of breast cancer cells.
authors.affiliation: Department of Chemistry, Department of Bioengineering, Department of Chemical Engineering, Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Chen
authors.forename: Fusayo
authors.initials: F
authors.lastname: Saeki
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Wiley
authors.forename: Hu
authors.initials: H
authors.lastname: Cang
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Cobb
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Li
authors.forename: Leslie
authors.initials: L
authors.lastname: Au
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Michael B
authors.initials: MB
authors.lastname: Kimmey
authors.forename: Xingde
authors.initials: X
authors.lastname: Li
authors.forename: Younan
authors.initials: Y
authors.lastname: Xia
mesh_terms: D045744:Cell Line, Tumor; D003287:Contrast Media; D003460:Crystallization / Q000379:methods; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000473:pathology*; D010316:Particle Size; D019047:Phantoms, Imaging; D020349:Surface Plasmon Resonance / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D003287:Contrast Media; D006046:Gold