title: Tolerability profiles of atypical antipsychotics in the treatment of bipolar disorder.
abstract: Atypical antipsychotics have unequivocally advanced the pharmacotherapy of bipolar disorder. These broad-spectrum medications offer efficacy against core symptoms of mania, and evidence supports the use of several agents as treatment options in depressed and maintenance phases of the disorder. Atypical antipsychotics also have a reduced propensity for provoking acute or tardive neurologic adverse events compared with their therapeutic predecessors, the conventional antipsychotics. These agents are not, however, a panacea and are associated with several problematic tolerability and safety concerns. Although classified together, atypical antipsychotics are heterogeneous in their tolerability and safety profiles, an issue that is relevant to individualizing treatment selection. This article reviews relevant adverse events attributable to the use of atypical antipsychotic agents, with particular consideration of the bipolar disorder population.
authors.affiliation: Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Ontario M5T 1R8, Canada. rmcintyr@uhnres.utoronto.ca
authors.forename: Roger S
authors.initials: RS
authors.lastname: McIntyre
authors.forename: Jakub Z
authors.initials: JZ
authors.lastname: Konarski
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000517:prevention & control / Q000523:psychology; D009202:Cardiomyopathies / Q000139:chemically induced; D003866:Depressive Disorder / Q000188:drug therapy / Q000517:prevention & control / Q000523:psychology; D003920:Diabetes Mellitus / Q000139:chemically induced; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced; D009205:Myocarditis / Q000139:chemically induced; D009765:Obesity / Q000139:chemically induced; D011247:Pregnancy; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D014150:Antipsychotic Agents