title: The role of endothelin-1 in myocarditis and inflammatory cardiomyopathy: old lessons and new insights.
abstract: Endothelin-1 has emerged as an important participant in the pathophysiology of a variety of cardiovascular diseases, where it may act on endocrine, paracrine and autocrine bases. Here we review its regulated biosynthesis, receptor-mediated signaling, and functional consequences in the heart, with particular emphasis on cardiac development and disease. Exploring published data employing molecular genetic mouse models of endothelin dysregulation, we highlight its heretofore underappreciated role as a pro-inflammatory cytokine. We also present novel micro-array data from one such mouse model, which implicate the specific downstream pathways that may mediate endothelin-1's effects.
authors.affiliation: Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Toronto, ON, Canada.
authors.forename: Li L
authors.initials: LL
authors.lastname: Yang
authors.forename: Sara
authors.initials: S
authors.lastname: Arab
authors.forename: Peter
authors.initials: P
authors.lastname: Liu
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Stewart
authors.forename: Mansoor
authors.initials: M
authors.lastname: Husain
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000235:genetics / Q000378:metabolism*; D019332:Endothelin-1 / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D009205:Myocarditis / Q000235:genetics / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D019332:Endothelin-1