title: Life-threatening asthma in children: treatment with sodium bicarbonate reduces PCO2.
abstract: OBJECTIVE
  To assess the effect of administration of sodium bicarbonate on carbon dioxide levels in children with life-threatening asthma (LTA) and to evaluate the clinical effect of this treatment.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  A pediatric ICU (PICU) of a tertiary care university hospital.
  
  
  METHODS
  Seventeen children with LTA who received sodium bicarbonate.
  
  
  RESULTS
  In January 1999, a new protocol for the treatment of LTA was initiated in our institution, incorporating the use of IV sodium bicarbonate in acidotic patients (pH < 7.15) with refractory status asthmaticus. Since January 1999, sodium bicarbonate was administered to 17 patients; 5 patients received two or three doses of sodium bicarbonate. In three patients, sodium bicarbonate was administered after intubation. Intubation and mechanical ventilation were performed in five patients before admission to the PICU, and in one patient during admission. There was a significant decrease of Pco(2) after sodium bicarbonate infusion (p = 0.007). An improvement of respiratory distress in all but one patient was seen as well.
  
  
  CONCLUSIONS
  Administration of sodium bicarbonate in 17 children with LTA was associated with a significant decrease in Pco(2) and an improvement of respiratory distress. The possible benefits of sodium bicarbonate in LTA deserve further study in a controlled, prospective design.
authors.affiliation: Division of Pediatric Intensive Care, Erasmus MC-Sophia Children's Hospital, Dr. Molewaterplein 60, 3015 GJ Rotterdam, the Netherlands. c.buysse@erasmusmc.nl
authors.forename: Corinne M P
authors.initials: CM
authors.lastname: Buysse
authors.forename: Johan C
authors.initials: JC
authors.lastname: de Jongste
authors.forename: Matthijs
authors.initials: M
authors.lastname: de Hoog
mesh_terms: D000138:Acidosis / Q000188:drug therapy* / Q000209:etiology; D000293:Adolescent; D002245:Carbon Dioxide / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007442:Intubation, Intratracheal; D008297:Male; D012121:Respiration, Artificial; D017693:Sodium Bicarbonate / Q000008:administration & dosage*; D013224:Status Asthmaticus / Q000097:blood* / Q000150:complications / Q000503:physiopathology / Q000628:therapy
chemical_list: D002245:Carbon Dioxide; D017693:Sodium Bicarbonate