title: Consumption of sesame oil muffins decreases the urinary excretion of gamma-tocopherol metabolites in humans.
abstract: Sesame seed and oil consumption previously increased human plasma gamma-tocopherol (gamma-T) concentrations. This was attributed to the sesame lignans sesamin and sesamolin. Here, we studied the inhibition of vitamin E metabolism by a single dose of sesame oil lignans coingested with deuterated alpha- and gamma-tocopherols in human volunteers. The urinary excretion of gamma-T metabolites was significantly lower in sesame oil treated than in control subjects. Concentrations of tocopherols in blood were not affected by the treatment. In conclusion, a single dose of sesame oil, containing 136 mg sesame lignans (sesamin and sesamolin), reduces the urinary excretion of co-administered gamma-T in humans.
authors.affiliation: Department of Food Science, Swedish University of Agricultural Sciences, Box 7051, 750 07 Uppsala, Sweden. jan.frank@lmv.slu.se
authors.forename: Jan
authors.initials: J
authors.lastname: Frank
authors.forename: Afaf
authors.initials: A
authors.lastname: Kamal-Eldin
authors.forename: Maret G
authors.initials: MG
authors.lastname: Traber
mesh_terms: D002839:Chromans / Q000652:urine; D003903:Deuterium; D004032:Diet; D004149:Dioxoles / Q000008:administration & dosage; D005502:Food; D006801:Humans; D007700:Kinetics; D017705:Lignans / Q000008:administration & dosage; D012715:Sesame Oil / Q000008:administration & dosage*; D024502:alpha-Tocopherol / Q000008:administration & dosage; D024504:gamma-Tocopherol / Q000008:administration & dosage / Q000652:urine*
chemical_list: D002839:Chromans; D004149:Dioxoles; D017705:Lignans; C483420:carboxyethyl-hydroxychroman; C054124:sesamolin; D012715:Sesame Oil; D024504:gamma-Tocopherol; D003903:Deuterium; D024502:alpha-Tocopherol; C054125:sesamin