title: [Case report of limited form of Wegener's granulomatosis detected by a health examination with no subjective symptoms].
abstract: A 60-year-old woman with no subjective symptoms was admitted to our hospital because of chest radiograph abnormality detected by a health examination. A computed tomographic scan of the thorax showed multiple nodules in both lungs without cavitation. Other organ lesions were not detected. Specimens from transbronchial lung biopsy revealed non-specific granuloma with necrosis. Antituberculous therapy was not effective, and serum PR 3-ANCA revealed to be positive. So we performed an excisional biopsy of the lung by video-assisted thoracoscopic surgery. The specimens showed necrotizing vasculitides, and granulomata which consisted of mainly lymphocytes, epithelioid cells and Langhans' giant cells. We here report a rare case of a patient with a limited form of Wegener's granulomatosis suffering from no subjective symptoms detected by a health examination.
authors.affiliation: Department of Internal Medicine, Izumi City Hospital.
authors.forename: Masato
authors.initials: M
authors.lastname: Uji
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Shibazaki
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Matsushita
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D033162:Incidental Findings; D008875:Middle Aged; D010808:Physical Examination; D011239:Prednisolone / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D003520:Cyclophosphamide; D011239:Prednisolone