[Transcriptional control of vitamin D1alpha-hydroxylase gene by PTH].
The vitamin D1alpha-hydroxylase plays a critical role in the vitamin D actions as a key enzyme for vitamin D biosynthesis. Reflecting its significant role, the gene expression is under control of multiple hormones. PTH and calcitonin up-regulate, but vitamin D represses the expression of this gene. The functional analyses of the gene promoter identified the regulatory element and the binding factor to control transcription in response to hormones.
Kato
S
S
Institute of Molecular and Cellular Biosciences, University of Tokyo.