Aspirin resistance and a single gene.
This study examined the association of single nucleotide polymorphisms in 4 candidate genes in a cohort of subjects with aspirin resistance. Aspirin resistance was significantly associated with genetic variation in the platelet surface adenosine 5-diphosphate receptor gene P2Y1.
Jefferson
Brian K
BK
Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Foster
Jennifer H
JH
McCarthy
Jeanette J
JJ
Ginsburg
Geoffrey
G
Parker
Alex
A
Kottke-Marchant
Kandice
K
Topol
Eric J
EJ
D000483:Alleles; D015906:Angioplasty, Balloon, Coronary; D001241:Aspirin / Q000008:administration & dosage*; D001792:Blood Platelets / Q000378:metabolism; D003327:Coronary Disease / Q000235:genetics* / Q000628:therapy; D004252:DNA Mutational Analysis; D004351:Drug Resistance / Q000235:genetics*; D005091:Exons; D005819:Genetic Markers / Q000235:genetics*; D005838:Genotype; D006720:Homozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008432:Mathematical Computing; D010974:Platelet Aggregation / Q000187:drug effects / Q000235:genetics; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011292:Premedication; D018048:Receptors, Purinergic P2 / Q000235:genetics; D058472:Receptors, Purinergic P2Y1
D005819:Genetic Markers; C546382:P2RY1 protein, human; D010975:Platelet Aggregation Inhibitors; D018048:Receptors, Purinergic P2; D058472:Receptors, Purinergic P2Y1; D001241:Aspirin