Patterns of brain activation in patients with mild Alzheimer's disease during performance of subtraction: an fMRI study.
We performed a functional MRI (fMRI) study to compare the difference of activation between healthy aged people and patients with mild Alzheimer's disease (AD) during performance of subtraction. Nine patients with mild AD and nine healthy aged volunteers were recruited in this study. The analysis of fMRI data revealed that brain activation is decreased in several regions in AD patients in comparison with healthy participants. But in the right inferior prefrontal lobe, activation is greater in patients than in the controls. We believe that our findings will help the understanding mechanism of neuronal activity in AD.
Xie
Sheng
S
Department of Radiology, Peking University First Hospital, Peking 100034, China.
Xiao
Jiang Xi
JX
Bai
Jing
J
Jiang
Xue Xiang
XX
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008433:Mathematics; D008606:Mental Processes; D009483:Neuropsychological Tests; D013647:Task Performance and Analysis