Skew-Laplace distribution in Gram-negative bacterial axenic cultures: new insights into intrinsic cellular heterogeneity.
The application of flow cytometry and skew-Laplace statistical analysis to assess cellular heterogeneity in Gram-negative axenic cultures is reported. In particular, fit to the log-skew-Laplace distribution for cellular side scatter or 'granulosity' is reported, and a number of theoretical and applied issues are considered in relation to the biological significance of this fit.
Julià
Olga
O
Departament d'Estadística, Facultat de Matemàtiques, Universitat de Barcelona, Gran Via, 585, 08007-Barcelona, Spain.
Vives-Rego
Josep
J
Departament de Microbiologia, Universitat de Barcelona, Av. Diagonal, 645, 08028-Barcelona, Spain.
D003470:Culture Media; D003627:Data Interpretation, Statistical; D005434:Flow Cytometry / Q000706:statistics & numerical data; D006090:Gram-Negative Bacteria / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D016013:Likelihood Functions; D008962:Models, Theoretical
D003470:Culture Media