Oral antiresorptive therapy.
Oral antiresorptive agents play a pivotal role in the management of osteoporosis. This paper discusses the effects and potential future role of newer agents such as ibandronate. Alternative dosing schedules and routes of administration have become available and may improve fracture protection, compliance, and tolerability for the long term treatment of a chronic condition such as osteoporosis. Increasingly these agents are being used to reduce bone loss in other diseases associated with high risk for osteoporosis such as organ transplantation and cystic fibrosis. Such studies may act as prototypes for the extended use of this class of drugs in other chronic inflammatory disease states. The innovative, yet disappointing results from combining an antiresorptive agent (alendronate) with the anabolic effects of teriparatide is also discussed. The major problem that remains is the lack of direct comparison between the agents in terms of fracture endpoints.
Pande
Ira
I
Department of Medicine, City Hospital, Hucknall Road, Nottingham NG5 1PB, United Kingdom.
Hosking
David J
DJ
D000284:Administration, Oral; D019386:Alendronate / Q000008:administration & dosage; D045930:Anabolic Agents / Q000008:administration & dosage*; D001862:Bone Resorption / Q000188:drug therapy*; D004164:Diphosphonates / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D012968:Etidronic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D050723:Fractures, Bone / Q000209:etiology; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D000077557:Ibandronic Acid; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy*; D020849:Raloxifene Hydrochloride / Q000008:administration & dosage; D000068296:Risedronic Acid; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage*; D019379:Teriparatide / Q000008:administration & dosage
D045930:Anabolic Agents; D004164:Diphosphonates; D005938:Glucocorticoids; D020845:Selective Estrogen Receptor Modulators; D019379:Teriparatide; D020849:Raloxifene Hydrochloride; D000068296:Risedronic Acid; D012968:Etidronic Acid; D000077557:Ibandronic Acid; D019386:Alendronate