title: Abnormal development of the thymus in "nude" mice.
abstract: Nude mice bearing grafts of normal thymus reject skin grafts and have low, but higher than usual, lymphocyte counts. Nude bone marrow can successfully repopulate the thymus and thymus-derived areas of lethelly irradiated recipient mice. Attempts to reconstitute nude mice with normal fetal liver failed. The so-called thymic rudiment of nude mice when grafted to normal mice did not develop thymocytes. These experiments show that nude mice suffer from a defect of the epithelial portion of the thymus rather than of the precursors of thymocytes.
authors.forename: H H
authors.initials: HH
authors.lastname: Wortis
authors.forename: S
authors.initials: S
authors.lastname: Nehlsen
authors.forename: J J
authors.initials: JJ
authors.lastname: Owen
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation; D016332:Fetal Tissue Transplantation; D016031:Liver Transplantation; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008819:Mice, Nude / Q000276:immunology*; D010280:Parathyroid Glands / Q000473:pathology; D016038:Skin Transplantation; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology* / Q000637:transplantation