title: [Drug exanthema in connection with trimethoprim and sulfamethoxazole treatment, triggered by leech therapy].
abstract: In a 58-year-old hospitalized woman with gonarthrosis a leech therapy was applied to both knee joints. In the evening of the following day she observed strong pruritus in the area of the leech bites; in addition a maculopapular exanthema appeared on the torso and her lower extremities. The allergic reaction lasted four days. Administration of antihistamines only led to a slight improvement of the symptoms. A full restitution could only be achieved after a systemic dose of glucocorticoids on the fourth day after leech therapy. Eight days before beginning of the leech therapy a five-day antibiotic therapy with trimethoprim and sulfamethoxazole (Cotrim forte) had been administered to treat an uncomplicated urinary infection. Allergic reactions are well-known complications of these antibiotics and of leech therapy. The four-day duration of the allergic reaction after leech therapy, however, was untypical. In order to explain these symptoms, a prick test and an epicutaneous test for the antibiotic components were executed five weeks after the leech therapy. Furthermore, a second leech therapy was administered and a lymphocyte transformation test (LTT) was carried out. The results of the LTT showed a sensitization for sulfamethoxazole and a possible sensitization for trimethoprim, the results of the epicutaneous test showed a positive reaction to sodium lauryl sulfate, a component of the antibiotic. In the area of the leech bites a clear local skin reaction was observed. These results suggest a drug exanthema, in all probability triggered by the leech therapy.
authors.affiliation: Modellabteilung für Naturheilkunde, Klinik Blankenstein, Hattingen. a-m.beer@web.de
authors.forename: André-Michael
authors.initials: AM
authors.lastname: Beer
authors.forename: Stefan
authors.initials: S
authors.lastname: Fey
authors.forename: Jens
authors.initials: J
authors.lastname: Ciborovius
authors.forename: Martin
authors.initials: M
authors.lastname: Knorr
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology; D005076:Exanthema / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D024763:Leeching / Q000009:adverse effects*; D008213:Lymphocyte Activation; D008875:Middle Aged; D012882:Skin Tests; D013420:Sulfamethoxazole / Q000009:adverse effects / Q000627:therapeutic use; D014295:Trimethoprim / Q000009:adverse effects / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D014295:Trimethoprim; D013420:Sulfamethoxazole