title: [ED-71].
abstract: ED-71 is a potent analog of active vitamin D, 1,25 (OH) (2)D(3), bearing a hydroxypropoxy substituent at the 2beta-position. In ovariectomized rats, ED-71 prevented the reduction in bone mass and strength of lumber spine without causing hypercalcemia. From those results, it was suggested that ED-71 preferentially enhances bone formation with less effects on intestinal calcium absorption. In osteoporotic patients, oral daily administration of ED-71 (0.25, 0.5, 0.75 and 1.0 microg) for 6 months increased bone mineral density (BMD) at L(2-4) in a dose-dependent manner. ED-71 also exhibited a dose-depend suppression of urinary deoxypyridinoline with no significant reduction in serum osteocalcin. These results demonstrate that ED-71 can effectively increase bone mass without causing hypercalcemia, and suggest that ED-71 can be a promising candidate for the treatment of osteoporosis with prominent effect on bone formation.
authors.affiliation: Chugai Pharmaceutical Co., Ltd.
authors.forename: Koichi
authors.initials: K
authors.lastname: Endo
authors.forename: Naoki
authors.initials: N
authors.lastname: Tsuji