title: Capsule 13C-urea breath test for the diagnosis of Helicobacter pylori infection.
abstract: OBJECTIVE
  To compare the accuracy of capsule 13C-urea breath test (UBT) with conventional invasive methods for the diagnosis of Helicobacter pylori infection.
  
  
  METHODS
  One hundred patients received CLO test, histological examination, culture and 100- or 50-mg capsule UBT for the diagnosis of H pylori infection. H pylori infection was defined as those with positive culture or positive results from both histology and CLO test.
  
  
  RESULTS
  Both the sensitivity and specificity of the 100-mg capsule UBT (n = 50) were 100%. The sensitivity and specificity of the 50-mg capsule UBT (n = 50) were 96.4 and 100%, respectively. Taken together, the accuracy of capsule UBT (n = 100) was higher than that of CLO test, histology and culture (100% vs 92%, 91% and 89%, respectively; P = 0.035, 0.018 and 0.005, respectively). Our data showed that the optimal timing of sampling for 100- and 50-mg capsule UBT was 15-30 and 6-15 min, respectively.
  
  
  CONCLUSIONS
  Capsule UBT has a higher accuracy compared with biopsy-based tests. It is an ideal method for the diagnosis of H pylori infection.
authors.affiliation: Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, China.
authors.forename: Nan-Jing
authors.initials: NJ
authors.lastname: Peng
authors.forename: Kwok-Hung
authors.initials: KH
authors.lastname: Lai
authors.forename: Ren-Shyan
authors.initials: RS
authors.lastname: Liu
authors.forename: Shui-Cheng
authors.initials: SC
authors.lastname: Lee
authors.forename: Daw-Guey
authors.initials: DG
authors.lastname: Tsay
authors.forename: Ching-Chu
authors.initials: CC
authors.lastname: Lo
authors.forename: Huei-Hwa
authors.initials: HH
authors.lastname: Tseng
authors.forename: Wen-Keui
authors.initials: WK
authors.lastname: Huang
authors.forename: Gin-Ho
authors.initials: GH
authors.lastname: Lo
authors.forename: Ping-I
authors.initials: PI
authors.lastname: Hsu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001944:Breath Tests / Q000379:methods*; D002214:Capsules; D002247:Carbon Isotopes; D005243:Feces / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014508:Urea / Q000378:metabolism*
chemical_list: D002214:Capsules; D002247:Carbon Isotopes; D014508:Urea