title: Emerging medical and surgical management strategies in the evaluation and treatment of intracerebral hemorrhage.
abstract: Intracerebral hemorrhage (ICH) accounts for approximately 10% of all strokes and causes high morbidity and mortality. Rupture of the small perforating vessels of the cerebral arteries is caused by chronic hypertension, which induces pathologic changes in the small vessels and accounts for most cases of ICH; however, amyloid angiopathy and other secondary causes are being seen more frequently with the increasing age of the population. Recent computed tomographic studies have revealed that ICH is a dynamic process with up to one third of initial hemorrhages expanding within the first several hours of ictus. Secondary injury is believed to result from the development of cerebral edema and the release of specific neurotoxins associated with the breakdown products of hemoglobin. Treatment is primarily supportive. Surgical evacuation is the treatment of choice for patients with neurologic deterioration from infratentorial hematomas. Randomized trials comparing surgical evacuation to medical management have shown no benefit of surgical removal of supratentorial hemorrhages. New strategies focusing on early hemostasis, improved critical care management, and less invasive surgical techniques for clot evacuation are promising to decrease secondary neurologic injury. We review the pathophysiology of ICH, its medical management, and new treatment strategies for improving patient outcome.
authors.affiliation: Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA.
authors.forename: Edward M
authors.initials: EM
authors.lastname: Manno
authors.forename: John L D
authors.initials: JL
authors.lastname: Atkinson
authors.forename: Jivui R
authors.initials: JR
authors.lastname: Fulgham
authors.forename: Eelco F M
authors.initials: EF
authors.lastname: Wijdicks
mesh_terms: D000428:Alcohol Drinking; D000927:Anticonvulsants / Q000627:therapeutic use; D002533:Cerebral Angiography; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D006406:Hematoma / Q000150:complications; D006470:Hemorrhage / Q000150:complications; D006801:Humans; D015994:Incidence; D007442:Intubation, Intratracheal; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008353:Mannitol / Q000627:therapeutic use; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000927:Anticonvulsants; D008353:Mannitol