1H Magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patients.
Neuroimaging and postmortem studies have suggested the involvement of the dorsolateral prefrontal cortex (DLPFC) in the pathophysioloy of unipolar disorder. We examined with in vivo 1H magnetic resonance spectroscopy (MRS) the levels of specific metabolites in the DLPFC of adult unipolar patients and the role of illness chronicity on DLPFC abnormalities. Nineteen unmedicated unipolar mood disorder patients and 19 age- and gender-matched healthy controls underwent a short echo-time 1H MRS examination localized to an 8-cm3 single voxel placed in the left DLPFC. There were no significant differences in metabolite levels, including N-acetylaspartate (NAA), phosphocreatine plus creatine (PCr+Cr) and choline-containing-compounds (GPC+PC), between the two groups. However, NAA/PCr+Cr ratios were significantly lower in the chronic than in the less chronically ill patients and healthy controls. The low levels of NAA/PCr+Cr ratios in the left DLPFC of unipolar patients who had been more chronically ill suggest a potential role for illness chronicity in neuronal abnormalities in the DLPFC in unipolar disorder. This could possibly be accounted for by neurodegenerative processes arising with the progression of the illness. Future 1H MRS investigations should longitudinally examine the role of illness chronicity on DLPFC abnormalities and their relationship with the symptoms of unipolar disorder.
Brambilla
Paolo
P
Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA.
Stanley
Jeffrey A
JA
Nicoletti
Mark A
MA
Sassi
Roberto B
RB
Mallinger
Alan G
AG
Frank
Ellen
E
Kupfer
David J
DJ
Keshavan
Matcheri S
MS
Soares
Jair C
JC
D000328:Adult; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D019964:Mood Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000002:abnormalities* / Q000503:physiopathology*; D011522:Protons; D012720:Severity of Illness Index
D011522:Protons