An fMRI investigation of covertly and overtly produced mono- and multisyllabic words.
Studies suggest that the left insula may play an important role in speech motor programming. We used functional magnetic resonance imaging to investigate the role of the left insula in the production of monosyllabic or multisyllabic words during overt and covert speech conditions. The left insula did not show a BOLD response for multisyllabic words (which should require more speech motor programming) that was different from that for monosyllabic words. Left parietal lobe regions showed a greater response for multisyllabic as compared to monosyllabic words. This is consistent with clinical studies showing that left parietal lobe lesions can produce a deficit in speech programming. Despite similarities, covert and overt speech did not demonstrate the same patterns of BOLD response. The BOLD response was greater during overt speech in areas that have been shown to play an important role in speech production including left premotor cortex/BA6, left primary motor cortex, left insula, and left superior temporal gyrus.
Shuster
Linda I
LI
Department of Speech Pathology and Audiology, Center for Advanced Imaging, West Virginia University, Morgantown, WV 26506-9236, USA. lshuster@wvu.edu
Lemieux
Susan K
SK
D000161:Acoustic Stimulation; D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D019416:Head Movements; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology; D013060:Speech / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology