title: Application of technetium-99m-labeled human serum albumin scan to assist surgical treatment of protein-losing enteropathy in Cronkhite-Canada syndrome: report of a case.
abstract: Cronkhite-Canada syndrome is a rare form of nonhereditary gastrointestinal polyposis associated with ectodermal change and protein-losing enteropathy. Here we report a 63-year-old male presenting with diffuse gastrointestinal polyposis, onychodystrophy, cutaneous pigmentation, alopecia, diarrhea, hypoalbuminemia and lower leg edema. Technetium-99m-labeled human serum albumin scan confirmed the patient to have protein-losing enteropathy, which originated from the transverse and descending colon. Subtotal colectomy was performed. Albumin level and ectodermal change were gradually improved during three years of outpatient clinic follow-up. Based on our finding, Technetium-99m-labeled human serum albumin scintigraphy is helpful to localize the protein-losing origins and surgery is an effective treatment for Cronkhite-Canada syndrome with protein-losing enteropathy.
authors.affiliation: Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia-Yi, Taiwan.
authors.forename: Kuo-Chih
authors.initials: KC
authors.lastname: Tseng
authors.forename: Bor-Shyang
authors.initials: BS
authors.lastname: Sheu
authors.forename: Jenq-Chang
authors.initials: JC
authors.lastname: Lee
authors.forename: Hong-Ming
authors.initials: HM
authors.lastname: Tsai
authors.forename: Nan-Tsing
authors.initials: NT
authors.lastname: Chiu
authors.forename: Yuan-Chang
authors.initials: YC
authors.lastname: Dai
mesh_terms: D003082:Colectomy / Q000379:methods*; D004487:Edema / Q000209:etiology; D006801:Humans; D044483:Intestinal Polyposis / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery*; D007866:Leg / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000209:etiology; D011504:Protein-Losing Enteropathies / Q000000981:diagnostic imaging* / Q000601:surgery*; D011877:Radionuclide Imaging; D012709:Serum Albumin; D013667:Technetium; D016896:Treatment Outcome
chemical_list: D012709:Serum Albumin; D013667:Technetium