Implantable gastric stimulation inhibits gastric motility via sympathetic pathway in dogs.
BACKGROUND
The aim of this study was to investigate the effect of implantable gastric stimulation (IGS) on gastric antral contractions and the involvement of the sympathetic pathway.


METHODS
The study was performed in 5 postprandial sessions in 8 dogs chronically implanted with stimulation electrodes and a gastric cannula: a) IGS via lesser curvature; b) IGS via antrum; c) and d) same as a) and b) but IGS initiated 1 hr before the meal; e) same as a) but with guanethidine.


RESULTS
It was found that: 1) IGS significantly inhibited postprandial antral contractions assessed by manometry, and no significant difference was noted in the effect between the two stimulation sites; 2) IGS initiated 1 hr before the meal was more potent than that initiated 30 minutes after the meal; 3) the inhibitory effect of IGS on postprandial antral motility was completely blocked by guanethidine.


CONCLUSIONS
Acute IGS inhibits postprandial antral contractions, and this inhibitory effect is mediated via the sympathetic pathway.
Zhu
Hongbing
H
Veterans Research Foundation, Oklahoma City, OK, USA.
Chen
Jiande D Z
JD
D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004558:Electric Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D016065:Myoelectric Complex, Migrating / Q000502:physiology; D009765:Obesity / Q000503:physiopathology / Q000628:therapy*; D019518:Postprandial Period; D011336:Probability; D012680:Sensitivity and Specificity; D013564:Sympathetic Nervous System / Q000502:physiology