title: Effect of adhesion barrier (Interceed TC7) on two-stage orchidopexy operation.
abstract: OBJECTIVE
  In two-stage orchidopexy, adhesions formed after the first stage usually cause difficulty during the second operation and may even lead to injury to the testis itself or to the spermatic cord. We investigated whether the use of adhesion-preventing barriers in the abdominal or pelvic region during surgery could lessen adhesions formed during two-stage orchidopexy and thus ease dissection.
  
  
  METHODS
  The study subjects comprised 21 male, albino, 30-day-old Wistar rats that were divided into three equal groups. In Group 1, the right testes were enveloped in adhesion barriers after dissection and sutured to the inguinal canal. In Group 2, the right testes were sutured to the inguinal canal without the barriers. In Group 3 (sham-operated group), all testes were dissected but no suturing was performed. Rats were sacrificed after 21 days and the ipsilateral testes were harvested.
  
  
  RESULTS
  Dissection of barrier-enveloped testes was relatively easy; however, no significant (p < 0.535) difference was seen in adhesion scores between Groups 1 and 2. Total tissue collagen was estimated by means of the hydroxyproline content. Tissue hydroxyproline levels were 16.04 +/- 8.58, 13.20 +/- 6.34 and 14.71 +/- 5.51 microg/mg wet tissue in Groups 1-3, respectively and these differences were not significant. The histopathologic evaluation revealed significant differences only in the thickness of the tunica albuginea in Groups 1 and 2 (110.0 +/- 30.0 vs 77.1 +/- 21.3 microm, respectively; p < 0.038).
  
  
  CONCLUSIONS
  The adhesion scores and the biochemical and histopathological examinations showed that an adhesion barrier is not beneficial in two-stage orchidopexy.
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. kgenc@softhome.net
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Genc
authors.forename: Fatma
authors.initials: F
authors.lastname: Taneli
authors.forename: Omer
authors.initials: O
authors.lastname: Yilmaz
authors.forename: Peyker
authors.initials: P
authors.lastname: Turkdogan
authors.forename: Oguz Alp
authors.initials: OA
authors.lastname: Arslan
authors.forename: Aydin
authors.initials: A
authors.lastname: Sencan
authors.forename: Can
authors.initials: C
authors.lastname: Taneli
mesh_terms: D000818:Animals; D002483:Cellulose, Oxidized / Q000494:pharmacology*; D003456:Cryptorchidism / Q000601:surgery*; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control; D011336:Probability; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D013737:Testis / Q000473:pathology* / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control*; D013520:Urologic Surgical Procedures / Q000379:methods*
chemical_list: D002483:Cellulose, Oxidized; C060002:INTERCEED