title: Increase of antibody titer against Leucocytozoon caulleryi by oral administration of recombinant R7 antigen.
abstract: In this study, we examined oral administration with recombinant R7 (rR7) antigen expressed in Escherichia coli using chicken leucocytozoonosis subunit vaccine (LV)-vaccinated and unvaccinated chickens. Only LV-vaccinated chickens showed re-induction of anti-second-generation schizont (2GS) antibody. Also, LV-vaccinated chickens whose anti-2GS antibody titer was middle-level showed increases of the antibody titer compared to vaccinated-control chickens (P>0.01, >0.05) after oral administration with rR7 antigen.
authors.affiliation: Research Center for Biologicals, The Kitasato Institute, Kitamoto 364-0026, Saitama, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ito
authors.forename: Tohru
authors.initials: T
authors.lastname: Gotanda
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Kume
authors.forename: Chihiro
authors.initials: C
authors.lastname: Sugimoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsumura
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology*; D000953:Antigens, Protozoan / Q000008:administration & dosage / Q000276:immunology*; D002645:Chickens / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D016787:Haemosporida / Q000276:immunology*; D013997:Time Factors
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan