[The study on pathogenesis of latex allergy.].
OBJECTIVE
In order to study the pathogenesis of latex allergy and the significance in the prevention and cure of occupational diseases.


METHODS
651 cases in the out-patient department were tested with skin prick test (SPT), and the specific IgE (sIgE) to latex were detected by means of disk ELISA and Western-blot.


RESULTS
It was found that the positive rate of latex SPT (37.5%) and sIgE (31.25%) were rather higher in patients in comparison with those of the normal. The positive rate of latex sIgE was much higher in the high-risk group than that of the low-risk group and the normal. The serum of the patients can react with multi-bands in the latex glove extracts.


CONCLUSIONS
The prevalence of latex allergy is rather high, this disease is mediated by IgE. The people in high-risk should be tested by latex allergy in order to take proper occupational and daily protection.
Li
Ning
N
The Department of Immunology and Rheumatology, Qingdao Municipal Hospital, Qingdao 266011, China.
Cehn
Bo
B
Xu
Yi-ping
YP
Wang
Jian-hua
JH
Wu
Zu-qun
ZQ
Zou
Han-bing
HB
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D020315:Latex Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D010045:Outpatients; D012882:Skin Tests; D055815:Young Adult
D007073:Immunoglobulin E