title: Cardiopulmonary and acid-base effects of desflurane and sevoflurane in spontaneously breathing cats.
abstract: The cardiopulmonary effects of desflurane and sevoflurane anesthesia were compared in cats breathing spontaneously. Heart (HR) and respiratory (RR) rates; systolic (SAP), diastolic (DAP) and mean arterial (MAP) pressures; partial pressure of end tidal carbon dioxide (PETCO2), arterial blood pH (pH), arterial partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2); base deficit (BD), arterial oxygen saturation (SaO2) and bicarbonate ion concentration (HCO3) were measured. Anesthesia was induced with propofol (8+/-2.3mg/kg IV) and maintained with desflurane (GD) or sevoflurane (GS), both at 1.3 MAC. Data were analyzed by analysis of variance (ANOVA), followed by the Tukey test (P<0.05). Both anesthetics showed similar effects. HR and RR decreased when compared to the basal values, but remained constant during inhalant anesthesia and PETCO2 increased with time. Both anesthetics caused acidemia and hypercapnia, but BD stayed within normal limits. Therefore, despite reducing HR and SAP (GD) when compared to the basal values, desflurane and sevoflurane provide good stability of the cardiovascular parameters during a short period of inhalant anesthesia (T20-T60). However, both volatile anesthetics cause acute respiratory acidosis in cats breathing spontaneously.
authors.affiliation: Department of Veterinary Clinics and Surgery, Veterinary Surgery Program, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Rod. Professor Paulo Donato Castelane, s/n. CEP: 14884-900, Jaboticabal, SP., Brazil.
authors.forename: Almir Pereira
authors.initials: AP
authors.lastname: Souza
authors.forename: Piedad Natalia Henao
authors.initials: PN
authors.lastname: Guerrero
authors.forename: Celina Tie
authors.initials: CT
authors.lastname: Nishimori
authors.forename: Danielli Parrilha
authors.initials: DP
authors.lastname: Paula
authors.forename: Paulo Sergio Patto
authors.initials: PS
authors.lastname: Santos
authors.forename: Marlis Langenegger
authors.initials: ML
authors.lastname: de Rezende
authors.forename: Newton
authors.initials: N
authors.lastname: Nunes
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000704:Analysis of Variance; D000769:Anesthesia, Inhalation / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects; D000077335:Desflurane; D006339:Heart Rate / Q000187:drug effects; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008738:Methyl Ethers / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D010313:Partial Pressure; D011651:Pulmonary Artery / Q000187:drug effects; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects*; D000077149:Sevoflurane; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane