title: Discrimination of normal and malignant gastric tissues with FTIR spectroscopy and principal component analysis.
abstract: In this paper, the identification of normal and malignant gastric tissues, including 11 cases of cancerous tissues and 10 cases of normal tissues, was investigated using mid-IR spectroscopy and principal componentanalysis (PCA). The results indicated that the difference between cancerous and normal tissues was found in the first principal component. The IR detection and PCA results are in agreement with the biopsy results. The combination of these two methods might provide a new opportunity for clinical application.
authors.affiliation: Department of Chemistry, College of Letters and Sciences, University of Idaho, ID 83844, USA.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Griffiths
authors.forename: Hu-sheng
authors.initials: HS
authors.lastname: Yang
authors.forename: Qing-bo
authors.initials: QB
authors.lastname: Li
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Ling
authors.forename: Jian-sheng
authors.initials: JS
authors.lastname: Wang
authors.forename: Li-min
authors.initials: LM
authors.lastname: Yang
authors.forename: Yi-zhuang
authors.initials: YZ
authors.lastname: Xu
authors.forename: Shi-fu
authors.initials: SF
authors.lastname: Weng
authors.forename: Jin-guang
authors.initials: JG
authors.lastname: Wu
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005260:Female; D006801:Humans; D009363:Neoplasm Proteins; D025341:Principal Component Analysis / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016707:Tissue Fixation
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins