title: [Osteoclastic bone resorption in the joint destruction of rheumatoid arthritis].
abstract: Osteoclastic bone resorption plays a central role in the joint destruction of rheumatoid arthritis patients. Several bone resorptive cytokines are implied to contribute to the mechanism through induction of RANKL/ODF in synovial cells and/or activated T cells. The target of the RA therapy should be focused on this destructive aspect in relation to the original RA pathophysiology.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, University of Tokyo.
authors.forename: H
authors.initials: H
authors.lastname: Kawaguchi