Effects of chronic ethanol treatment on glial fibrillary acidic protein expression in adult rat optic nerve: an immunocytochemical study.
Glial fibrillary acidic protein (GFAP) is used as a marker of astrocyte response to various central nervous system injuries. In the present study, the effects of chronic ethanol administration on GFAP immunoreactivity were evaluated in astrocytes of the adult optic nerve head. The results demonstrated that ethanol exposure significantly and dramatically increases GFAP immunoreactivity and the number of immunoreactive astrocytes (p<0.001). In addition, GFAP immunoreactive cells in the optic nerve showed extensive hypertrophy (p<0.001).
Gonca
Süheyla
S
Department of Histology and Embryology, Faculty of Medicine, Kocaeli University, 41900 Derince, Izmit-Kocaeli, Turkey. sgonca@superonline.com
Filiz
Serdar
S
Dalçik
Cannur
C
Yardimoğlu
Melda
M
Dalçik
Hakki
H
Yazir
Yusufhan
Y
Erden
B Faruk
BF
D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009900:Optic Nerve / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D005904:Glial Fibrillary Acidic Protein; D000431:Ethanol