[The study on HLA-Cw polymorphism from Xi'an Han population by PCR-sequence specific oligonucleotide probe].
OBJECTIVE
To determine the HLA-Cw allele and genotype frequencies from Xi'an Han population and obtain genetic data.


METHODS
The results of HLA-Cw typing for 130 randomly selected from Xi'an Han population were obtained by using the PCR-Sequence Specific Oligonucleotide Probes (SSOP).


RESULTS
In this investigation, 16 alleles were detected among 130 unrelated individuals with frequencies from 0.0077 to 0.1588 and HLA-Cw*01,03,07 were the most common HLA-Cw alleles. We have made a survey of HLA-Cw alleles frequencies in Xi'an Han Population, with blank frequency being lowered to 0.018 2.


CONCLUSIONS
The distribution of genotype frequencies met the law of Hardy-Weinberg equilibrium by Hi-square test. The frequency data can be used in forensic and paternity tests, transplant matching and anthropology.
Zhang
Hong-bo
HB
The National Laboratory of the Ministry of Health for Forensic Sciences, Xi'an Jiaotong University, Xi'an 710061, China. zhanghb@mail.xjtu.edu.cn
Lai
Jiang-hua
JH
Zhao
Jun-hai
JH
Li
Shengbin
S
D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China / Q000208:ethnology; D005787:Gene Frequency; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction / Q000379:methods*; D011110:Polymorphism, Genetic
D015236:HLA-C Antigens; D015345:Oligonucleotide Probes