title: Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity.
abstract: A formylated triterpene named cladocalol has been isolated from the leaves of Eucalyptus cladocalyx, together with ursulolactone acetate, ursolic acid, 3 beta-acetate-12,20(29)-lupadien-28-oic acid, beta-sitosterol and the known flavonoid eucalyptine. Their structures were mainly established by extensive NMR studies (1H NMR, 13C NMR, DEPT, 1H-1H COSY, HSQC, HMBC) and mass spectroscopy as well as by X-ray crystallographic analysis. In this paper, we report on the cytotoxic effect induced by cladocalol and its derivatives on the myeloid leukemia cell line HL-60.
authors.affiliation: Laboratory of Valorisation of Natural Resources, University of Constantine, Constantine 25000, Algeria.
authors.forename: Samira
authors.initials: S
authors.lastname: Benyahia
authors.forename: Samir
authors.initials: S
authors.lastname: Benayache
authors.forename: Fadila
authors.initials: F
authors.lastname: Benayache
authors.forename: Francisco
authors.initials: F
authors.lastname: León
authors.forename: José
authors.initials: J
authors.lastname: Quintana
authors.forename: Matías
authors.initials: M
authors.lastname: López
authors.forename: Juan C
authors.initials: JC
authors.lastname: Hernández
authors.forename: Francisco
authors.initials: F
authors.lastname: Estévez
authors.forename: Jaime
authors.initials: J
authors.lastname: Bermejo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005052:Eucalyptus / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C501182:cladocalo