title: [Clinicopathologic significance of CD105 mRNA expression in human breast carcinoma].
abstract: OBJECTIVE
  To study endoglin (CD105) gene expression in breast cancer and its clinicopathologic significance.
  
  
  METHODS
  In 40 patients with breast cancers, CD105 mRNA was detected at center and periphery of tumor and at nearby normal tissue by RT-PCR.
  
  
  RESULTS
  The difference in CD105 mRNA expressions between cancer and normal breast tissue was significant (t = 12.08, P < 0.05), and the expression was significantly higher at the tumor periphery than at the tumor center (t = 7.52, P < 0.05). CD105 over-expression was related to lymph node metastases (t = 2.71, P < 0.05), but not to age, tumor size, pathologic grade or pathologic type (P > 0.05).
  
  
  CONCLUSIONS
  CD105 over-expression may play a crucial role in the progression of breast cancer and lymph node metastasis.
authors.affiliation: Department of Abdominal Surgery, The Third Affiliated Hospital Of Harbin Medical University, Harbin 150040, China. hljpangda@sina.vip.com
authors.forename: Da
authors.initials: D
authors.lastname: Pang
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Ying-Wei
authors.initials: YW
authors.lastname: Xue
authors.forename: Qi-Fan
authors.initials: QF
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D000071063:Endoglin; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011956:Receptors, Cell Surface; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D019010:Vascular Cell Adhesion Molecule-1