title: Effect of deferiprone on urinary zinc excretion in multiply transfused children with thalassemia major.
abstract: A prospective multi-centric study was conducted to determine if iron-chelating agent deferiprone also chelates zinc. Twenty four-hour urinary zinc levels were compared in multiply transfused children with thalassemia major not receiving any chelation therapy (Group A, n = 28), those receiving deferiprone (Group B, n = 30) and age and sex-matched controls of subjects in Group B (Group C, n = 29) by a colorimetric method. The 24-hour mean urinary excretion of zinc was significantly higher in Group B than in the other two groups indicating that deferiprone chelates zinc.
authors.affiliation: Department of Pediatrics, Seth G.S. Medical College and KEM Hospital, Mumbai, India.
authors.forename: Sandip
authors.initials: S
authors.lastname: Bartakke
authors.forename: S B
authors.initials: SB
authors.lastname: Bavdekar
authors.forename: Pratima
authors.initials: P
authors.lastname: Kondurkar
authors.forename: Mamta N
authors.initials: MN
authors.lastname: Muranjan
authors.forename: Mamata V
authors.initials: MV
authors.lastname: Manglani
authors.forename: Ratna
authors.initials: R
authors.lastname: Sharma
mesh_terms: D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D000077543:Deferiprone; D005260:Female; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D008297:Male; D011446:Prospective Studies; D011728:Pyridones / Q000627:therapeutic use*; D019233:Retreatment; D013997:Time Factors; D015032:Zinc / Q000652:urine*; D017086:beta-Thalassemia / Q000628:therapy / Q000652:urine*
chemical_list: D007502:Iron Chelating Agents; D011728:Pyridones; D000077543:Deferiprone; D015032:Zinc