Characterization of N(6)-cyclohexyladenosine-induced hypothermia in Syrian hamsters.
The N(6)-cyclohexyladenosine (CHA)-induced hypothermia in Syrian hamsters was characterized as follows: intracerebroventricular injection of CHA-induced hypothermia and the potency was increased by lowering the ambient temperature. CHA microinjection into the anterior hypothalamus (AH) elicited the most marked body temperature (T(b)) decrease compared with other regions such as the preoptic area, dorsomedial hypothalamus, posterior hypothalamus, and hippocampus. In contrast, microinjected CHA into the medial septum, ventromedial hypothalamus, and lateral hypothalamus resulted in negligible changes in T(b). These results suggest that CHA-induced hypothermia was probably due to suppression of thermogenesis via the site(s) of CHA action, viz., the AH and medial hypothalamus.
Shintani
Mitsuteru
M
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima.
Tamura
Yutaka
Y
Monden
Mayuko
M
Shiomi
Hirohito
H
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D006224:Cricetinae; D007032:Hypothalamus, Anterior / Q000187:drug effects / Q000502:physiology; D007036:Hypothermia, Induced; D007276:Injections, Intraventricular; D008647:Mesocricetus; D008845:Microinjections; D013696:Temperature
D000241:Adenosine