Interleukin-10 genotypes are associated with systemic sclerosis and influence disease-associated autoimmune responses.
Systemic sclerosis (SSc; scleroderma) is a connective tissue disease, characterized by fibrotic, immunological, and vascular abnormalities. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that modulates collagen production and B-cell survival. To determine if certain IL-10 genotypes are risk factors for the development of SSc and influence disease-associated autoimmune responses, 248 Caucasian and 264 Japanese SSc patients and controls were genotyped for three loci: -3575, -2849, and -2763. Sera from patients were characterized for SSc-associated autoantibodies. In Caucasians, at -3575 and -2763, the frequency of AA homozygotes was higher in patients as compared with controls (P=0.0005; P=0.002). In Japanese subjects, the frequency of AC heterozygotes at -2763 was higher, and that of CC homozygotes lower, in patients with diffuse SSc as compared to controls (P=0.04). Particular IL-10 genotypes were associated with SSc-related autoantibodies. These results suggest that IL-10 genotypes contribute to the etiology of scleroderma.
Hudson
L L
LL
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425-2230, USA.
Rocca
K M
KM
Kuwana
M
M
Pandey
J P
JP
D015551:Autoimmunity / Q000235:genetics* / Q000276:immunology; D016009:Chi-Square Distribution; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D007564:Japan; D012595:Scleroderma, Systemic / Q000235:genetics* / Q000276:immunology; D044465:White People
D016753:Interleukin-10