Molecular evidence of Pneumocystis transmission in pediatric transplant unit.
We describe an outbreak of Pneumocystis jirovecii pneumonia in a pediatric renal transplant unit, likely attributable to patient-to-patient transmission. Single-strand conformation polymorphism molecular typing showed that 3 affected patients had acquired the same 2 strains of Pneumocystis, which suggests interhuman infection. An infant with mitochondriopathy was the probable index patient.
Höcker
Britta
B
University Children's Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany. Britta_Hoecker@med.uni-heidelberg.de
Wendt
Constanze
C
Nahimana
Aimable
A
Tönshoff
Burkhard
B
Hauser
Philippe M
PM
D000293:Adolescent; D003428:Cross Infection / Q000276:immunology / Q000382:microbiology* / Q000635:transmission; D004272:DNA, Mitochondrial / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D018562:Disease Transmission, Infectious; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D045363:Pneumocystis carinii; D011020:Pneumonia, Pneumocystis / Q000276:immunology / Q000635:transmission*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D012335:RNA, Ribosomal / Q000737:chemistry / Q000235:genetics
D004272:DNA, Mitochondrial; D021903:DNA, Ribosomal Spacer; D004279:DNA, Viral; D012335:RNA, Ribosomal; C065096:RNA, ribosomal, 26S