[Regulation of osteoclastic function through cell surface receptors].
Osteoclasts express various surface-molecules involved in the regulation of osteoclastic function as well as osteoclastogenesis. Receptor activator NF kappa B (RANK:the receptor for RANKL), IL-1 receptor and integrin alpha(v)beta(3) act as positive regulators of osteoclastic bone resorption. Blockage of their function results in the inhibition of bone resorption. The calcitonin receptor (CTR) acts as the specific negative regulator for osteoclastic bone resorption and ideal regulation could be realized through this receptor, however, it is necessary to overcome the calcitonin escape phenomenon. A unique cell surface antigen (Kat1-antigen) regulating the function of CTR may be involved in the incidence of the calcitonin escape phenomenon.
Kukita
Toshio
T
Oral Cellular and Molecular Biology, Division of Oral Biological Sciences, Faculty of Dental Science, Kyushu University.
Kukita
Akiko
A