Genetic control of susceptibility to autoimmune gastritis.
A familial component to the tendency to develop autoimmune gastritis has long been recognized. Although linkage to certain HLA alleles and an association with the endocrine autoimmune diseases thyroiditis and type 1 diabetes have been reported, little further progress has been achieved in clinical studies. In contrast, the mouse model of gastritis induced in the BALB/c strain by thymectomy in the third day of life has identified four linkage regions; two on distal chromosome 4 (Gasa1 and Gasa2), one on chromosome 6 (Gasa3) and one in the H2 (Gasa4). Three of these four genes colocalize with NOD mouse diabetes susceptibility genes--the strongest concordance identified to date between any two autoimmune diseases--reflecting the association between autoimmune diabetes and type 1 gastritis in humans.
Baxter
Alan G
AG
Comparative Genomics Centre, James Cook University, Townsville, QLD, Australia. Alan.Baxter@jcu.edu.au
Jordan
Margaret A
MA
Silveira
Pablo A
PA
Wilson
Wendy E
WE
Van Driel
Ian R
IR
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics*; D048909:Diabetes Complications / Q000235:genetics; D004195:Disease Models, Animal; D005756:Gastritis / Q000235:genetics* / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D051379:Mice