Hypereosinophilic dermatitis-like erythema annulare centrifugum in a patient with chronic lymphocytic leukaemia.
A 65-year-old male presented with a history of disseminated erythema annulare centrifugum lesions and a high peripheral blood eosinophilia (55%). Histopathology of a lesion revealed a superficial and deep perivascular and interstitial inflammatory eosinophilic infiltrate. The bone marrow aspirate showed a heavy eosinophilic infiltrate. There was no evidence of any other systemic involvement except for bone marrow eosinophilia. The patient had a 6-year history of chronic lymphocytic leukaemia. The disease is in complete remission for the last 3 years. The clinical and histopathological findings in the reported patient correspond to the diagnosis of hypereosinophilic dermatitis. Topical treatment with corticosteroid creams was successful. The cutaneous lesions gradually resolved in 8 weeks, within 7 months the peripheral blood eosinophilia slowly declined from 55% to 7%.
Miljković
J
J
Department of Dermatology, General Hospital Maribor, SI-2000 Maribor, Slovenia. miljkovic.j@sb-mb.si
Bartenjev
I
I
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D003872:Dermatitis / Q000150:complications* / Q000473:pathology; D004804:Eosinophils / Q000473:pathology; D004890:Erythema / Q000150:complications* / Q000473:pathology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D012867:Skin / Q000473:pathology*