[The mutants of calcineurin transgenic mice].
It has been reported that the constitutively active form of calcineurin transgenic mice showed significant cardiac hypertrophy and heart failure, and that the development of cardiac hypertrophy in the transgenic mice was suppressed by inhibitors for calcineurin. We recently generated the transgenic mice overexpressing the dominant negative mutants of calcineurin specifically in the heart and observed in the transgenic mice that pressure overload-induced cardiac hypertrophy was significantly attenuated as compared to wild type mice.
Zou
Y
Y
Department of Cardiovascular Science of Medicine, Chiba University Graduate School of Medicine.
Komuro
I
I