title: [Large vessel vasculitis as cause of fever of unknown origin (FUO) or systemic inflammation. Diagnosis using 18-F-fluor-2-deoxy-D-glucose positron emission tomography ((18)F-FDG-PET)].
abstract: BACKGROUND
  Diagnosis and treatment of FUO or systemic inflammation with unknown reason are still a great challenge for the treating physician. We used (18)F-FDG-PET for further diagnostic work in patients in whom a diagnosis could not be established despite intensive diagnostic efforts.
  
  
  RESULTS
  We studied nine patients with (18)F-FDG-PET. Two female patients with known Takayasu's arteritis but undefined disease activity, and seven patients with the clinical suspicion of an underlying large vessel vasculitis. The diagnosis of active vasculitis could be confirmed by the PET-results in eight patients. Active vasculitis could be nearly ruled out in one. The diagnoses could be confirmed by follow-up visits.
  
  
  CONCLUSIONS
  (18)F-FDG-PET is a useful diagnostic tool in patients with unclear systemic inflammation and FUO. Especially when large vessel vasculitis is suspected, further diagnostic work by PET seems to be of benefit. Furthermore, it offers the opportunity to evaluate disease activity and to check which vessels are involved.
authors.affiliation: Medizinische Klinik und Polikliniken der Eberhardt-Karls-Universität Tübingen, Abteilung II Hämatologie, Onkologie, Immunologie und Rheumatologie, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany.
authors.forename: C C
authors.initials: CC
authors.lastname: Amberger
authors.forename: H
authors.initials: H
authors.lastname: Dittmann
authors.forename: D
authors.initials: D
authors.lastname: Overkamp
authors.forename: K
authors.initials: K
authors.lastname: Brechtel
authors.forename: R
authors.initials: R
authors.lastname: Bares
authors.forename: I
authors.initials: I
authors.lastname: Kötter
mesh_terms: D000328:Adult; D000368:Aged; D003951:Diagnostic Errors / Q000517:prevention & control*; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis* / Q000209:etiology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011875:Radionuclide Angiography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018746:Systemic Inflammatory Response Syndrome / Q000000981:diagnostic imaging* / Q000209:etiology; D014657:Vasculitis / Q000150:complications / Q000000981:diagnostic imaging*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18