title: [Malondialdehyde and reduced glutathione increase in patients with chronic stable ischaemic cardiopathy].
abstract: OBJECTIVE
  Cardiovascular diseases are associated with the ischemia/reperfusion phenomena and therefore to the oxidation/antioxidation balance. The aim of this study was to determine malondialdehyde, nitric oxide, glutathione, ascorbic and dehydroascorbic acid in patients with chronic ischemic heart disease.
  
  
  METHODS
  32 male patients, with chronic ischemic heart disease, between 40 and 60 years of age were studied. These individuals were divided in two groups: 16 with hypertension and 16 without hypertension. Both groups were compared with 31 healthy male subjects (control group).
  
  
  RESULTS
  Significant differences (p < 0.001) was observed in malondialdehyde between no-hypertension ischemic group: 5.3 (1.5) microM and the hypertension ischemic group: 4.8 (1.3) microM in contrast with the healthy group: 2.2 (0.5) microM. Hypertension ischemic group showed significant greater reduced glutation levels: 286.1 (31.4) microg/ml than control group 262.0 (38.8) microg/ml; p < 0.03 and no-hypertension ischemic group: 256.4 (41.5) microg/ml; p < 0.02. No significant difference in the rest of the parameters for all study groups.
  
  
  CONCLUSIONS
  Oxidation/antioxidation balance during chronic ischemic heart disease can be considered as a good metabolic ischemia indicator, that used in the monitoring and therapeutic evaluation could detect molecular changes that anticipate installation of tissue damage.
authors.affiliation: Centro de Investigaciones Endocrino-metabólicas Dr. Félix Gómez, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
authors.forename: Mayela Carolina
authors.initials: MC
authors.lastname: Cabrera de Bravo
authors.forename: Valmore José
authors.initials: VJ
authors.lastname: Bermúdez Pirela
authors.forename: Fernando
authors.initials: F
authors.lastname: Bermúdez Arias
authors.forename: Clímaco
authors.initials: C
authors.lastname: Cano Ponce
authors.forename: Edgardo José
authors.initials: EJ
authors.lastname: Mengual Moreno
authors.forename: Elliuz Marina
authors.initials: EM
authors.lastname: Leal González
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004562:Electrocardiography; D005978:Glutathione / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000378:metabolism*
chemical_list: D008315:Malondialdehyde; D005978:Glutathione