title: Mitosis: PARty time in the spindle.
abstract: Poly(ADP-ribose), a post-translational protein modification known to affect chromatin structure, has now been shown to regulate microtubule organization during mitosis. These findings alter conventional views of the mechanisms of spindle assembly and function.
authors.affiliation: Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. duane.a.compton@dartmouth.edu
authors.forename: Duane A
authors.initials: DA
authors.lastname: Compton
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism; D020090:Chromosome Segregation / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism* / Q000502:physiology; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism* / Q000502:physiology
chemical_list: D018797:Cell Cycle Proteins; D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases