title: Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure.
abstract: We evaluated the in vitro phagocytic function and the production of microbicidal oxygen radicals by monocytes and neutrophils of 9 Chagas' heart disease subjects with heart failure and 9 without the syndrome in comparison with 11 healthy subjects, by assessing phagocytosis of Saccharomyces cerevisiae and NBT reduction by peripheral blood phagocytes. Phagocytic index of monocytes of chagasics without heart failure was significantly 6.7 and 10.6 times lower than those of controls and chagasics with the congestive syndrome, respectively, due to a lesser engagement in phagocytosis and to an inability of these cells to ingest particles. Neutrophils also show in chagasics without heart failure PI 11.2 and 19.8 times lower than that of controls and chagasics with heart failure, respectively. The percent of NBT reduction was normal and similar for the three groups. Balanced opposite effects of cardiovascular and immune disturbances may be acting in Chagas' disease subjects with heart failure paradoxically recovering the altered phagocytic function.
authors.affiliation: Laboratório de Imunologia Celular da Faculdade de Medicina da Universidade de Brasília, Brasília, DF, Brasil. mimjunqueira@unb.br
authors.forename: Maria Imaculada
authors.initials: MI
authors.lastname: Muniz-Junqueira
authors.forename: Lícia Maria
authors.initials: LM
authors.lastname: Mota
authors.forename: Rodrigo Barbosa
authors.initials: RB
authors.lastname: Aires
authors.forename: Luiz Fernando
authors.initials: LF
authors.lastname: Junqueira Júnior
mesh_terms: D000293:Adolescent; D000328:Adult; D001770:Blood Bactericidal Activity; D016022:Case-Control Studies; D002598:Chagas Cardiomyopathy / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000502:physiology*; D009504:Neutrophils / Q000276:immunology / Q000502:physiology*; D009580:Nitroblue Tetrazolium; D010587:Phagocytosis; D017382:Reactive Oxygen Species; D012441:Saccharomyces cerevisiae
chemical_list: D017382:Reactive Oxygen Species; D009580:Nitroblue Tetrazolium