title: [Multiple malignant neoplasms in patients with prostate tumours in the health district of Leon].
abstract: OBJECTIVE
  We analyze the characteristics of the patients with prostate tumours who developed a multiple malignant primary neoplasms (MMPN) in the health district of León, the impact on survival and the prognostic variables.
  
  
  METHODS
  We have used the data from the Tumour Registry of the Hospital of León and we have selected all those patients who were diagnosed of a prostate tumor between 1993 and 2002. Later we made two groups: the first with 67 patients with MMPN and a second group with 145 patients with single prostate tumours diagnosed during 1996 and 1997.
  
  
  RESULTS
  Prevalence of MMPM was of 5.57 percent. Patients with MMPN were 3 years younger than those with single tumours, with a high frequency (41 percent) of familial oncologic antecedents on first degree parents. The more frequent association was the synchronous urologic neoplasm. During the next two years from diagnosed of prostate tumour, 86 percent of patients with MMPN were diagnosed of their second neoplasm. Survival of metachronous MMPN patients was lower than synchronous MMPN patients, being the variables with prognosis significance the age, metachronous MMPN, stage of second neoplasms and if the second neoplasms was or not urologic.
  
  
  CONCLUSIONS
  MMPN in patients with prostatic tumours are frequent in our medium. A genetic base may be associated in these patients. Prognosis of metachronous MMPN patients is worse. No differences were observed about prognosis with single tumour patients.
authors.affiliation: Servicio de Medicina Interna, Hospital de León, León. albmuela@yahoo.es
authors.forename: A
authors.initials: A
authors.lastname: Muela Molinero
authors.forename: F
authors.initials: F
authors.lastname: Jorquera Plaza
authors.forename: R
authors.initials: R
authors.lastname: Malagón Rojo
authors.forename: M T
authors.initials: MT
authors.lastname: Ribas Ariño
authors.forename: M
authors.initials: M
authors.lastname: Muñoz Rodríguez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D015995:Prevalence; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000453:epidemiology*; D013030:Spain / Q000453:epidemiology; D016019:Survival Analysis