title: Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin.
abstract: In the present study, the biochemical manifestations of liver toxicity caused by co-administration of anti-TB drugs, rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA), in a sub-chronic mode (12 weeks), were investigated. Significant alterations were revealed in (a) increased levels of alanine aminotrasferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) and a high bilirubin content in serum; (b) elevated lipid peroxidation (LPO), intracellular calcium [Ca(2+)](i) and CYP4502EI activity in liver; and (c) decreased glutathione (GSH) content, glutathione peroxidase (GPx) and catalase activities in liver. Silymarin reversed these abnormal alterations. The biochemical changes were supported by histological observations.
authors.affiliation: Division of Pharmacology, Regional Research Laboratory (CSIR), Canal Road, Jammu-Tawi 180001, India.
authors.forename: Sheikh A
authors.initials: SA
authors.lastname: Tasduq
authors.forename: Kaiser
authors.initials: K
authors.lastname: Peerzada
authors.forename: Supriya
authors.initials: S
authors.lastname: Koul
authors.forename: Rinku
authors.initials: R
authors.lastname: Bhat
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Johri