title: Computational modeling of vascular anastomoses.
abstract: Recent development of computational technology allows a level of knowledge of biomechanical factors in the healthy or pathological cardiovascular system that was unthinkable a few years ago. In particular, computational fluid dynamics (CFD) and computational structural (CS) analyses have been used to evaluate specific quantities, such as fluid and wall stresses and strains, which are very difficult to measure in vivo. Indeed, CFD and CS offer much more variability and resolution than in vitro and in vivo methods, yet computations must be validated by careful comparison with experimental and clinical data. The enormous parallel development of clinical imaging such as magnetic resonance or computed tomography opens a new way toward a detailed patient-specific description of the actual hemodynamics and structural behavior of living tissues. Coupling of CFD/CS and clinical images is becoming a standard evaluation that is expected to become part of the clinical practice in the diagnosis and in the surgical planning in advanced medical centers. This review focuses on computational studies of fluid and structural dynamics of a number of vascular anastomoses: the coronary bypass graft anastomoses, the arterial peripheral anastomoses, the arterio-venous graft anastomoses and the vascular anastomoses performed in the correction of congenital heart diseases.
authors.affiliation: Bioengineering and Structural Engineering Department, Laboratory of Biological Structure Mechanics, Politecnico di Milano, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy. francesco.migliavacca@polimi.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Migliavacca
authors.forename: Gabriele
authors.initials: G
authors.lastname: Dubini
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001163:Arteriovenous Anastomosis / Q000033:anatomy & histology* / Q000473:pathology*; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity; D006321:Heart / Q000033:anatomy & histology; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D012984:Software