Natural killer cells: can they be useful as adoptive immunotherapy for cancer?
As part of the innate immune system, natural killer (NK) cells form the first line of defence against pathogens or transformed/cancerous host cells. Recent experimental and clinical data show the possibility of exploiting NK activity as a cell-based immunotherapy to treat cancer. This review discusses the recent knowledge on NK cell biology that has impacted on its development as a treatment for cancer.
Arai
Sally
S
Stanford University Medical Center, Division of Bone Marrow Transplant, 300 Pasteur Drive, H3249, MC 5623, Stanford, CA 94305, USA. sarai1@stanford.edu
Klingemann
Hans-G
HG
D000818:Animals; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D007694:Killer Cells, Natural / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy