title: HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses.
abstract: Several published epidemiologic studies show increased breast cancer risk for carriers of the Val-allele at codon 655 of the HER2 gene. We conducted additional analyses using data from three studies, including case-control analyses stratified on age and kin-cohort analyses using relatives of cases and controls. The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer.
authors.affiliation: Department of Epidemiology, School of Public Health, University of North Carolina, CB #7435, Chapel Hill, NC 27599-7435, USA. millikan@email.unc.edu
authors.forename: Robert C
authors.initials: RC
authors.lastname: Millikan
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Hummer
authors.forename: Mary S
authors.initials: MS
authors.lastname: Wolff
authors.forename: Asahi
authors.initials: A
authors.lastname: Hishida
authors.forename: Colin B
authors.initials: CB
authors.lastname: Begg
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D003062:Codon; D015331:Cohort Studies; D005260:Female; D018734:Genes, erbB-2; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D003062:Codon