title: Generic antiretroviral efficacy in AIDS-associated Kaposi's sarcoma in sub-Saharan Africa.
abstract: Generic antiretroviral drugs are pivotal in the implementation of WHO's '3 by 5' programme. However, clinical experience with generics in sub-Saharan Africa is insufficiently documented. We report on 50 patients with HIV-associated Kaposi's sarcoma treated with generic fixed-dose highly active antiretroviral therapy. At 52 weeks, 74% achieved an undetectable viral load of < 50 copies/ml, 86% achieved < 400 copies/ml, and a 3.1 log10 decline from baseline. Side-effects were minimal. The outcomes support the use of generic antiretroviral therapy.
authors.affiliation: Department of Dermatology, Africa Centre for Health and Population Studies, Durban, South Africa.
authors.forename: Anisa
authors.initials: A
authors.lastname: Mosam
authors.forename: Edana
authors.initials: E
authors.lastname: Cassol
authors.forename: Taryn
authors.initials: T
authors.lastname: Page
authors.forename: Uvani
authors.initials: U
authors.lastname: Bodasing
authors.forename: Sharon
authors.initials: S
authors.lastname: Cassol
authors.forename: Halima
authors.initials: H
authors.lastname: Dawood
authors.forename: Gerald H
authors.initials: GH
authors.lastname: Friedland
authors.forename: David T
authors.initials: DT
authors.lastname: Scadden
authors.forename: Jamila
authors.initials: J
authors.lastname: Aboobaker
authors.forename: Jacobus P
authors.initials: JP
authors.lastname: Jordaan
authors.forename: Umesh G
authors.initials: UG
authors.lastname: Lalloo
authors.forename: Tonya M
authors.initials: TM
authors.lastname: Esterhuizen
authors.forename: Hoosen M
authors.initials: HM
authors.lastname: Coovadia
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D017954:Africa South of the Sahara; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D003906:Developing Countries; D016568:Drugs, Generic / Q000627:therapeutic use*; D006801:Humans; D012514:Sarcoma, Kaposi / Q000188:drug therapy*; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D016568:Drugs, Generic