Effects of vitamin E depletion/repletion on biomarkers of oxidative stress in healthy aging.
The effects on ex vivo LDL resistance to oxidation and biomarkers of in vivo oxidative stress in response to 3-month dietary vitamin E restriction to 25% of recommended intake and 2-month unrestricted dietary intake and supplementation with 800 IU/d were studied in 100 healthy, nonsmoking 20-75-year-old volunteers. Significant changes in vitamin E status were associated with decreases and increases, respectively, in LDL resistance to oxidation in the depletion and supplementation period and with decreases in lipid peroxidation and oxidative DNA modification in the supplementation period. Healthy aging was not associated with enhanced susceptibility to oxidation in the depletion period.
Winklhofer-Roob
Brigitte M
BM
Human Nutrition & Metabolism Research and Training Center, Institute of Molecular Biosciences, Karl-Franzens University, Schubertstrasse 1, A-8010 Graz, Austria. brigitte.winklhoferroob@uni-graz.at
Meinitzer
Andreas
A
Maritschnegg
Michaela
M
Roob
Johannes M
JM
Khoschsorur
Gholamali
G
Ribalta
Josep
J
Sundl
Isabella
I
Wuga
Sandra
S
Wonisch
Willibald
W
Tiran
Beate
B
Rock
Edmond
E
D000328:Adult; D000368:Aged; D000375:Aging; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000032:analysis*; D002338:Carotenoids / Q000097:blood; D004247:DNA / Q000737:chemistry; D004912:Erythrocytes / Q000737:chemistry; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D008077:Lipoproteins, LDL; D014810:Vitamin E; D002338:Carotenoids; D004247:DNA; D005979:Glutathione Peroxidase