title: [Acute biocompatibility of hemodiafiltration with endogenous reinfusion (HFR)].
abstract: OBJECTIVE
  In order to reduce the hemodialysis (HD)-induced pro-inflammatory activity we need to use a biocompatible dialysis membrane, avoid backfiltration and possibly use adsorbents. Hemodiafiltration reinfusion (HFR) is a new on-line hemodiafiltration (HDF) technique combining these aspects. This study aimed to evaluate the biocompatibility of the single dialysis session comparing standard HD and HFR.
  
  
  METHODS
  Eighteen patients on chronic HD were enrolled in five Centers. Patients underwent one standard and two HFR study sessions; in each session we evaluated leukocyte activation at 0, 5, 15, 60 and 240 min; and interleukin-6 (IL-6), C-reactive protein (CRP) and IL-1 receptor antagonist (IL-1Ra) levels at 0, 60 and 240 min.
  
  
  RESULTS
  Leukocyte activation was similar in HD and HFR, while the post-dialysis IL-6 increase was lower with HFR; CRP levels were stable during HFR, but increased after HD, and IL-1Ra did not demonstrate any difference.
  
  
  CONCLUSIONS
  These preliminary data show that HFR still has a better biocompatibility in the single dialysis session.
authors.affiliation: U.O. di Nefrologia e Dialisi, Ospedale Casa Sollievo della Sofferenza IRCCS, San Giovanni Rotondo, Foggia. faucel@tin.it
authors.forename: F
authors.initials: F
authors.lastname: Aucella
authors.forename: A
authors.initials: A
authors.lastname: Gesuete
authors.forename: L
authors.initials: L
authors.lastname: Sereni
authors.forename: S
authors.initials: S
authors.lastname: Netti
authors.forename: A M
authors.initials: AM
authors.lastname: Savastano
authors.forename: M
authors.initials: M
authors.lastname: Querques
authors.forename: A
authors.initials: A
authors.lastname: Specchio
authors.forename: A
authors.initials: A
authors.lastname: De Min
authors.forename: C
authors.initials: C
authors.lastname: Avanzi
authors.forename: C
authors.initials: C
authors.lastname: Montemurno
authors.forename: E
authors.initials: E
authors.lastname: Grandone
authors.forename: F
authors.initials: F
authors.lastname: Cappucci
authors.forename: D A
authors.initials: DA
authors.lastname: Procaccini
authors.forename: C
authors.initials: C
authors.lastname: Stallone
authors.forename: L
authors.initials: L
authors.lastname: Gesualdo
mesh_terms: D017583:Hemodiafiltration / Q000379:methods*; D015312:Hemodialysis Solutions / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D014511:Uremia / Q000628:therapy*
chemical_list: D015312:Hemodialysis Solutions