title: Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis.
abstract: Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.
authors.affiliation: Second Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa City, Saitama 359-8513, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kato
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Tsuzuki
authors.forename: Ryota
authors.initials: R
authors.lastname: Hokari
authors.forename: Yoshikiyo
authors.initials: Y
authors.lastname: Okada
authors.forename: Junichi
authors.initials: J
authors.lastname: Miyazaki
authors.forename: Koji
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Iwai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawaguchi
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Nagao
authors.forename: Kazuro
authors.initials: K
authors.lastname: Itoh
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nabeshima
authors.forename: Soichiro
authors.initials: S
authors.lastname: Miura
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002452:Cell Count / Q000379:methods; D003092:Colitis / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D003106:Colon / Q000473:pathology; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D007150:Immunohistochemistry / Q000379:methods; D039641:Integrin beta Chains / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009088:Mucoproteins; D018847:Opioid Peptides / Q000172:deficiency / Q000502:physiology*; D013194:Staining and Labeling / Q000379:methods; D013997:Time Factors; D000097629:Nociceptin
chemical_list: D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D016264:Dextran Sulfate; D039641:Integrin beta Chains; D009088:Mucoproteins; D018847:Opioid Peptides; D000097629:Nociceptin; C489082:Madcam1 protein, mouse; C091368:integrin beta7