title: Occurrence of porphyria cutanea tarda during peginterferon/ribavirin therapy for chronic viral hepatitis C.
abstract: Porphyria cutanea tarda (PCT) is a metabolic disorder characterized by a reduced hepatic activity of uroporphynogen decarboxylase (URO-D), an enzyme of the heme synthesis. The clinical features of PCT may be brought into light by hepatic injury induced by hepatitis C virus (HCV). A significant association between HCV and PCT is well recognized, although the role of HCV in the appearance of PCT is still debated because confounding factors often coexist, such as alcohol, other viruses, drugs or iron overload (). HCV therapy may improve PCT although PCT was rarely reported as a de novo occurrence during an interferon/ribavirin therapy (Jessner et al. Hepatology 2002;36:1301-1302); here, we describe two such other cases.
authors.affiliation: Service d'Hépato-Gastroentérologie, Centre Hospitalier de Cambrai, 516 avenue de Paris, BP 389, 59407 Cambrai cedex, France. tthevenot@chu-besancon.fr
authors.forename: Thierry
authors.initials: T
authors.lastname: Thevenot
authors.forename: Claude
authors.initials: C
authors.lastname: Bachmeyer
authors.forename: Rabah
authors.initials: R
authors.lastname: Hammi
authors.forename: Patrice
authors.initials: P
authors.lastname: Dumouchel
authors.forename: Isabelle
authors.initials: I
authors.lastname: Ducamp-Posak
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Cadranel
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D017119:Porphyria Cutanea Tarda / Q000209:etiology* / Q000821:virology; D011994:Recombinant Proteins; D012254:Ribavirin / Q000008:administration & dosage
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a