Trisomy 12 and t(14;22)(q32;q11) in a patient with B-cell chronic lymphocytic leukemia.
Recurrent cytogenetic abnormalities are typically found in about one third of B-cell chronic lymphocytic leukemia patients (B-CLL) by standard cytogenetic analysis and their prognostic relevance is well known. We report a case of a B-CLL patient showing both trisomy 12 and a t(14;22)(q32;q11). Trisomy 12 is often associated with aggressive disease and resistance to chemotherapy, however, our patient is in good health and currently untreated after 7 years, suggesting in this case a relatively good prognosis and a questionable role for translocations involving the 14q32 locus.
Gozzetti
Alessandro
A
Department of Medicine and Immunological Sciences, Division of Hematology and Transplants, University of Siena, Italy. gozzetti@unisi.it
Marotta
Giuseppe
G
Lenoci
Mariapia
M
Crupi
Rosaria
R
Tozzuoli
Daniela
D
Calabrese
Simona
S
Forconi
Francesco
F
Fabbri
Alberto
A
Lauria
Francesco
F
D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D002892:Chromosomes, Human, Pair 22; D020732:Cytogenetic Analysis; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged; D014178:Translocation, Genetic; D014314:Trisomy