title: Saccharomyces boulardii induced sepsis: successful therapy with voriconazole after treatment failure with fluconazole.
abstract: Saccharomyces boulardii is frequently used for prevention and treatment of all forms of diarrhoea. We report the case of a 19-y-old white male with an underlying severe neurological disease, who developed a fungal sepsis after prophylactic application of a drug containing S. boulardii. Initial treatment with fluconazole was not successful. After the application of voriconazole, the sepsis resolved completely. This is the first clinical report of a successful treatment of Saccharomyces sepsis with voriconazole.
authors.affiliation: Department of Pulmonary and Critical Care Medicine, University Otto-von-Guericke, Magdeburg, Germany. olaf.burkhardt@medizin.uni-magdeburg.e
authors.forename: Olaf
authors.initials: O
authors.lastname: Burkhardt
authors.forename: Thomas
authors.initials: T
authors.lastname: Köhnlein
authors.forename: Mathias
authors.initials: M
authors.lastname: Pletz
authors.forename: Tobias
authors.initials: T
authors.lastname: Welte
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000627:therapeutic use*; D012440:Saccharomyces / Q000472:pathogenicity*; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D015725:Fluconazole; D065819:Voriconazole