title: [Contribution to the study of the anti-inflammatory activity of Moringa oleifera (moringaceae)].
abstract: Moringa oleifera is a bush of African savannah, used in folk Medicine for the treatment of rheumatic and articulary pain. We have tested the anti-inflammatory action of an aqueous extract of root in rats with weight between 120 and 160 g. We administered per os either distilled water (control group), the aqueous root extract (750 mg/kg or 1000 mg/kg) or indomethacin (10 mg/kg) 30 min before an oedema was induced in the rat-paw by subcutaneous injection of carrageenin. The rat-paw volume was measured 1, 3 and 5 hours after injection of carrageenin. At a dose of 750 mg/kg the Moringa oleifera treatment significantly inhibited the development of oedema at 1, 3 and 5 hours (reduction by 53.5, 44.6 and 51.1% respectively). Increasing the dose of Moringa oleifera to 1000 mg/kg did not increase the inhibitory effect on oedema development at 1 and 3 hours, whereas this dose potentiated the oedema at 5 hours. Treatment with indomethacin significantly inhibited the development of oedema 1, 3 and 5 hours (49.1, 82.1 and 46.9% respectively). These findings indicate that an aqueous root extract of Moringa oleifera at 750 mg/kg reduces the carrageenin induced oedema to similar extent as the potent anti-inflammatory drug indomethacin. Moreover, these results provide further evidence that the roots of Moringa oleifera contain anti-inflammatory principle that may be useful in the treatment of the acute inflammatory conditions.
authors.affiliation: Laboratoire de Pharmacologie et de Physiologie, UCAD, BP 5005, Dakar, Sérégal.
authors.forename: M
authors.initials: M
authors.lastname: Ndiaye
authors.forename: A M
authors.initials: AM
authors.lastname: Dieye
authors.forename: F
authors.initials: F
authors.lastname: Mariko
authors.forename: A
authors.initials: A
authors.lastname: Tall
authors.forename: A
authors.initials: A
authors.lastname: Sall Diallo
authors.forename: B
authors.initials: B
authors.lastname: Faye
mesh_terms: D000818:Animals; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D029588:Moringa oleifera; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D028321:Plant Preparations / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014867:Water
chemical_list: D010936:Plant Extracts; D028321:Plant Preparations; D014867:Water