title: [Resistance to the calcemic action of parathyroid hormone in chronic renal failure].
abstract: It is widely believed that the main mechanism of hypocalcemia in chronic renal failure is the blunted skeletal response to PTH, probably due to appearance of PTH7-84 or PTHR down-regulation in bone. We indicated that the down-regulation of renal PTHR mRNA could contribute to the development of the skeletal resistance for PTH in CRF rats. In addition, the presence of high circulating levels of non-1-84 PTH fragments (most likely 7-84 PTH) detected by the intact assay and the 1-84 PTH explain the need of high levels of intact PTH to prevent adynamic bone disease.
authors.affiliation: Department of Nutritional, School of Medicine, Tokushima University.
authors.forename: K
authors.initials: K
authors.lastname: Miyamoto
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Kuwahata