title: Effects of chronic ethanol treatment on glial fibrillary acidic protein expression in adult rat optic nerve: an immunocytochemical study.
abstract: Glial fibrillary acidic protein (GFAP) is used as a marker of astrocyte response to various central nervous system injuries. In the present study, the effects of chronic ethanol administration on GFAP immunoreactivity were evaluated in astrocytes of the adult optic nerve head. The results demonstrated that ethanol exposure significantly and dramatically increases GFAP immunoreactivity and the number of immunoreactive astrocytes (p<0.001). In addition, GFAP immunoreactive cells in the optic nerve showed extensive hypertrophy (p<0.001).
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine, Kocaeli University, 41900 Derince, Izmit-Kocaeli, Turkey. sgonca@superonline.com
authors.forename: Süheyla
authors.initials: S
authors.lastname: Gonca
authors.forename: Serdar
authors.initials: S
authors.lastname: Filiz
authors.forename: Cannur
authors.initials: C
authors.lastname: Dalçik
authors.forename: Melda
authors.initials: M
authors.lastname: Yardimoğlu
authors.forename: Hakki
authors.initials: H
authors.lastname: Dalçik
authors.forename: Yusufhan
authors.initials: Y
authors.lastname: Yazir
authors.forename: B Faruk
authors.initials: BF
authors.lastname: Erden
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009900:Optic Nerve / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005904:Glial Fibrillary Acidic Protein; D000431:Ethanol