title: Clinicopathologic features of epidermal cysts of the sole: comparison with traditional epidermal cysts and trichilemmal cysts.
abstract: BACKGROUND
  It has been described that the etiology of epidermal cysts on acral skin is different from that on non-acral skin; however, no papers have been published regarding the detailed histological differences between acral and non-acral epidermal cysts. In this study, we compared the clinicopathologic findings of epidermal cysts of the sole with those of traditional epidermal cysts and trichilemmal cysts.
  
  
  METHODS
  The cases studied were 12 epidermal cysts of the sole, 35 traditional (non-acral) epidermal cysts, and 12 trichilemmal cysts. The age and sex of the patients and the site, size, and microscopic findings of the lesions were evaluated. The pattern of keratinization was specifically focused on the evaluation of microscopic findings.
  
  
  RESULTS
  Microscopically, most of the epidermal cysts of the sole showed the presence of parakeratosis and focal lack of a granular layer at least at the upper portion of the cyst wall. The cyst content of the epidermal cysts of the sole was predominantly compact orthokeratotic material. These pathological findings could be explained by the pathogenesis of epidermal cysts of the sole, namely invagination of the surface epidermis.
  
  
  CONCLUSIONS
  Our study indicates that most cases of the epidermal cyst of the sole are considered to be a true traumatic epidermal inclusion cyst.
authors.affiliation: Departments of Pathology and Dermatology, Saitama Medical School, Saitama, Japan. shimizu@saitama-med.ac.jp
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakita
authors.forename: Eiichi
authors.initials: E
authors.lastname: Arai
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsuchida
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Ogawa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ban
authors.forename: Tomoko
authors.initials: T
authors.lastname: Mitsuhashi
authors.forename: Takanori
authors.initials: T
authors.lastname: Hirose
authors.forename: Michio
authors.initials: M
authors.lastname: Shimizu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002648:Child; D004814:Epidermal Cyst / Q000737:chemistry / Q000209:etiology / Q000473:pathology*; D005260:Female; D005528:Foot / Q000473:pathology*; D005533:Foot Dermatoses / Q000209:etiology / Q000473:pathology*; D018409:Foot Injuries / Q000150:complications / Q000473:pathology; D018859:Hair Follicle / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018396:Mucin-1 / Q000032:analysis; D014947:Wounds and Injuries / Q000150:complications / Q000473:pathology*
chemical_list: D002272:Carcinoembryonic Antigen; D018396:Mucin-1