title: Hepatoprotective and antioxidant effects of Morus bombycis Koidzumi on CCl4-induced liver damage.
abstract: The antioxidant activity and liver protective effect of Morus bombycis Koidzumi were investigated. Aqueous extracts of M. bombycis Koidzumi had higher superoxide radical scavenging activity than other types of extracts. The aqueous extract at a dose of 100 mg/kg showed significant hepatoprotective activity when compared with that of a standard agent. The biochemical results were confirmed by histological observations indicating that M. bombycis Koidzumi extract together with CCl(4) treatment decreased ballooning degeneration. The water extract recovered the CCl(4)-induced liver injury and showed antioxidant effects in assays of FeCl(2)-ascorbic acid-induced lipid peroxidation in rats. Based on these results, we suggest that the hepatoprotective effect of the M. bombycis Koidzumi extract is related to its antioxidative activity.
authors.affiliation: Division of Biotechnology, Kangwon National University, Chuncheon, Kangwon-do 200-701, Republic of Korea.
authors.forename: Ying-Shan
authors.initials: YS
authors.lastname: Jin
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Sa
authors.forename: Tae-Heum
authors.initials: TH
authors.lastname: Shim
authors.forename: Hae-Ik
authors.initials: HI
authors.lastname: Rhee
authors.forename: Myeong-Hyeon
authors.initials: MH
authors.lastname: Wang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002251:Carbon Tetrachloride; D004305:Dose-Response Relationship, Drug; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D031625:Morus / Q000737:chemistry*; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D002251:Carbon Tetrachloride