title: D-type fiber biosensor based on surface-plasmon resonance technology and heterodyne interferometry.
abstract: A D-type fiber biosensor based on surface-plasmon resonance (SPR) technology and heterodyne interferometry is presented. The sensing device is a single-mode optical fiber in which half the core is polished away and a thin-film layer of gold is deposited. We measure the phase-difference variations instead of the light intensity as in traditional SPR techniques. Therefore the accuracy and resolution of our method are very high. Its sensitivity can reach 2 x 10(-6) refractive-index units. The sensor has some merits, e.g., tunable high sensitivity, small size, lower cost, smaller sample volume, and suitability for in vivo testing. This novel method of a D-type fiber biosensor based on SPR technology and heterodyne interferometry is valuable for chemical, biological, and biochemical sensing, and the novel method of D-type fiber biosensing is a feasible means of study.
authors.affiliation: Department of Electro-Optical Engineering, National Huwei University of Science and Technology, 64 Wunhua Road, Huwei Yulin 632, Taiwan, China. mhchiu@nhust.edu.tw
authors.forename: Ming-Hung
authors.initials: MH
authors.lastname: Chiu
authors.forename: Shinn-Fwu
authors.initials: SF
authors.lastname: Wang
authors.forename: Rong-Seng
authors.initials: RS
authors.lastname: Chang
mesh_terms: D000438:Alcohols / Q000032:analysis* / Q000737:chemistry*; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005336:Fiber Optic Technology / Q000295:instrumentation* / Q000379:methods; D007368:Interferometry / Q000295:instrumentation* / Q000379:methods; D055100:Optical Fibers; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods
chemical_list: D000438:Alcohols