[PTH assay: whole PTH assay (new IRMA assay)].
The common intact-PTH assay detects not only PTH (1-84) but also PTH (7-84) fragment. Recently, it is reported that PTH (7-84) fragment is the antagonist to PTH (1-84) biological action. Thus, conventional intact-PTH assay might mislead the overestimation of parathyroid function in uremic patients. Whole PTH assay, which detect only PTH (1-84) fragments may be useful for more precise evaluation of PTH activity in uremic patient.
Tanno
Yudo
Y
Division of Nephrology and Hyper Tension, The Jikei University School of Medicine.
Shigematsu
Takashi
T