Effects of cadmium exposure during pregnancy on trace elements in fetal rat liver and kidney.
Female rats were exposed by intragastric administration with a cannula 1mg/kg/day or 10mg/kg/day CdCl2 for the 11 days from the 9th to 19th day of pregnancy, and the effects of Cd exposure on eight elements, Na, K, Ca, Mg, P, Fe, Zn, and Cu in fetal liver, kidney, brain, fetal membrane and placenta then examined. We found that: (1) although Cd was not detected in fetal kidney and brain, significant Cd accumulation was found in fetal liver, fetal membrane and placenta in the 10 mg/kg Cd group, (2) the Zn and Fe concentrations in fetal liver in the 10 mg/kg Cd group were significantly lower than those in the control group, but no difference was found in the placenta, (3) the Cu concentrations in the placenta, fetal membrane and liver in the 10 mg Cd groups were significantly lower than those in the control group, (4) Na/K ratio in the placenta and fetal kidney and the Ca concentration in the placenta in the 10 mg/kg Cd group were lower than those in the controls. These results suggest that Cd exposure inhibits Zn and Fe transportation from the placenta to fetus, as well as Cu, Ca, Na and K uptake and transportation across the placenta, possibly influencing fetal growth and metabolism.
Kuriwaki
Jun-ichi
J
Department of Public Health, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan.
Nishijo
Muneko
M
Honda
Ryumon
R
Tawara
Kenji
K
Nakagawa
Hideaki
H
Hori
Etsuro
E
Nishijo
Hisao
H
D000818:Animals; D001835:Body Weight; D001921:Brain / Q000196:embryology / Q000378:metabolism; D019256:Cadmium Chloride / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000378:metabolism*; D007668:Kidney / Q000196:embryology / Q000378:metabolism*; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D008670:Metals / Q000378:metabolism; D009929:Organ Size; D010920:Placenta / Q000737:chemistry / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D013054:Spectrophotometry, Atomic; D014131:Trace Elements / Q000378:metabolism*
D008670:Metals; D014131:Trace Elements; D019256:Cadmium Chloride