Synthesis of biologically active steroid derivatives by the utility of Lawesson's reagent.
Steroid derivatives V, VI, VII and VIII reacted with Lawesson's reagent (LR) to produce spiro-oxazaphosphole-4',17-androstene derivative XI, diazaphospholoandrostane XIV and the thionated derivatives XVI and XVII, respectively. The structures of the new compounds were confirmed by analytical and spectroscopic evidence. A mechanism accounting for the formation of the new compounds was given. The in vitro antimicrobial activity of the new compounds were tested.
Mohamed
Nadia R
NR
Photochemistry Department, National Research Centre, Dokki, Giza, Egypt. nadia_ragab_m@hotmail.com
Elmegeed
Gamal A
GA
Abd-ElMalek
Hoda A
HA
Younis
Magdi
M
D000736:Androstenes; D000890:Anti-Infective Agents / Q000494:pharmacology*; D008956:Models, Chemical; D013055:Spectrophotometry, Infrared; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry*
D000736:Androstenes; D000890:Anti-Infective Agents; D013256:Steroids