[Adsorption of substances on active charcoal. Part 2: basic esters of phenylcarbamic acid with beta-adrenolytic effect].
The paper is concerned with the study of adsorption on active charcoal in a set of selected substances from the group of aryloxyaminopropanol derivatives with carbamate substitution on the benzene ring with beta-adrenolytic effect (Group A) and a set of substances, derivatives of [(arylcarbonyl)oxylaminopropanol with the identical, but assumed ultra-short effect (Group B), where the effect was produced by replacing the phenolether group with a metabolically unstable ester functional group. The course of adsorption in buffer solution with pH 7 in dependence on time and concentration is examined. Adsorptivity of substances is evaluated according to Freundlich and Langmuir models. Affinity of substances of Group A to adsorption material decreases with increasing hydrophilicity.
Stankovicová
M
M
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava. stankovicm@fpharm.uniba.sk
Zlevská
Z
Z
Bezáková
Z
Z
Mokrý
P
P
Csöllei
J
J
D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D000327:Adsorption; D002606:Charcoal; D048448:Phenylcarbamates / Q000737:chemistry*
D000319:Adrenergic beta-Antagonists; D048448:Phenylcarbamates; D002606:Charcoal