title: Clear cell odontogenic carcinoma: a comprehensive analysis of treatment strategies.
abstract: BACKGROUND
  Odontogenic neoplasms of predominately clear cells are unusual. They represent a diagnostic dilemma, and as a result, treatment strategies are diverse. Our goal is to present two new cases, summarize reported cases of clear cell odontogenic carcinoma (CCOC), assess potential risk factors for recurrence, and propose definitive surgical and therapeutic strategies.
  
  
  METHODS
  A literature search and analysis was performed. Regression models were used to predict risk factors for recurrence.
  
  
  RESULTS
  Forty-three cases of CCOC were reviewed, including two reported here. The overall rate of recurrent disease was 55%. Local recurrence rates were higher for curettage (80%) than for resection alone (43%). Age (p = .20), sex (p = .28), and tumor site (p = .50) did not predict risk for recurrence.
  
  
  CONCLUSIONS
  CCOC is a potentially aggressive tumor with a tendency for recurrence. Treatment strategies should be directed toward wide surgical resection with confirmation of tumor-free margins. Lymph node dissection and adjuvant radiation therapy should be considered in selected cases.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, CB# 7070, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7070, USA. cebert@med.unc.edu
authors.forename: Charles S
authors.initials: CS
authors.lastname: Ebert
authors.forename: Marc G
authors.initials: MG
authors.lastname: Dubin
authors.forename: Craig F
authors.initials: CF
authors.lastname: Hart
authors.forename: Ara A
authors.initials: AA
authors.lastname: Chalian
authors.forename: William W
authors.initials: WW
authors.lastname: Shockley
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D009808:Odontogenic Tumors / Q000473:pathology / Q000601:surgery / Q000628:therapy*