[A new statistical method on familial correlation dealing with family data from case-control studies].
OBJECTIVE
This paper presents a statistical method of familial correlation on family data from case-control studies.


METHODS
Marginal mean models of the probands and the relatives conditional on the proband's disease status, as well as the marginal association model of the relatives were modeled integrately. Conditional odds-ratio and marginal odds-ratio were used to measure the familial correlation.


RESULTS
The parameter's interpretation in the model was in accordance with sample characteristics. This method is more efficient due to making fully use of information of the probands and relatives. In addition, the method has all advantages of GEE2.


CONCLUSIONS
The method in this paper efficiently and conveniently analyzes the family data from case-control studies to estimate the familial correlation on disease.
Gao
Yan-hui
YH
Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
Jiang
Qing-wu
QW
Zhou
Xue-fu
XF
Ding
Bao-guo
BG
Wang
Ru-hong
RH
Zhao
Gen-ming
GM
D015982:Bias; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003627:Data Interpretation, Statistical; D004812:Epidemiologic Methods; D005192:Family Health; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000235:genetics; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000235:genetics; D012307:Risk Factors