Renal metanephric adenoma with previously unreported cytogenetic abnormalities: case report and review of the literature.
We report a case of a renal metanephric adenoma in a 10-year-old boy, in which cytogenetic analysis showed a balanced translocation, t(9;15)(p24;q24) and a balanced paracentric inversion of chromosome 12, inv(12)(q13q15). Immunohistochemically, the tumor showed diffuse reactivity for cytokeratin AE1/AE3, CAM5.2, CD57, and WT1; patchy reactivity for CD56; and focal reactivity for cytokeratin 7, epithelial membrane antigen, and CD10. Tumor cells were entirely nonreactive for alpha-methyl acyl coenzyme A racemase. Published cytogenetic data for metanephric adenomas are limited, and this is the first report of these cytogenetic abnormalities. The involvement of the chromosome region 9p24 is particularly interesting because of the recent identification of a tumor suppressor gene, KANK (kidney ankyrin repeat-containing protein), at this locus.
Rakheja
Dinesh
D
Department of Pathology, Children's Medical Center of Dallas, 1935 Motor Street, Dallas, TX 75235, USA. dinesh.rakheja@utsouthwestern.edu
Lian
Fangru
F
Tomlinson
Gail E
GE
Ewalt
David H
DH
Schultz
Roger A
RA
Margraf
Linda R
LR
D000236:Adenoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D002871:Chromosome Banding; D007446:Chromosome Inversion / Q000235:genetics*; D002906:Chromosomes, Human, 6-12 and X / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics*
D014408:Biomarkers, Tumor