title: Prevalence of high-grade prostatic intraepithelial neoplasia and its relationship to serum prostate specific antigen.
abstract: OBJECTIVE
  We assessed the incidence of high-grade prostatic intraepithelial neoplasia (HGPIN) in prostates removed for bladder cancer, and evaluated its correlation with preoperative serum prostate specific antigen (PSA).
  
  
  METHODS
  We reviewed the histology of the prostate from men who underwent cystoprostatectomy for bladder cancer without known prostate pathology prior to surgery. Preoperative serum PSA levels in patients with HGPIN were analyzed.
  
  
  RESULTS
  61 cystoprostatectomy specimens from May 1992 to April 1999 were reviewed. High-grade prostatic intraepithelial neoplasia (PIN) was found in 46/61 (75%) of the prostate specimens, including 21/21 (100%) patients with prostatic cancer, and 25/40 (63%) patients without prostatic cancer. The mean serum PSA in men with PIN without evidence of prostatic adenocarcinoma was 1.9 ng/mL (SD=2.026).
  
  
  CONCLUSIONS
  The incidence of isolated high-grade PIN was 63%. The presence of high-grade PIN does not result in a significant elevation of serum PSA.
authors.affiliation: Department of Surgery, The University of Chicago, Chicago, Illinois 60637, USA.
authors.forename: Hyung L
authors.initials: HL
authors.lastname: Kim
authors.forename: Ximing J
authors.initials: XJ
authors.lastname: Yang