Mutation of the prothrombin gene and thrombotic events in patients with polycythemia vera or essential thrombocythemia: a cohort study.
The association between a prothrombin mutation and the risk of thrombosis was analyzed in 214 patients with polycythemia vera or essential thrombocythemia. The rate for venous thrombotic events was 14.7/100 patient-years in patients with the prothrombin mutation compared to 0.8 in patients without the mutation (rate ratio 17.5).
Gisslinger
Heinz
H
Müllner
Marcus
M
Pabinger
Ingrid
I
Heis-Vahidi-Fard
Navide
N
Gisslinger
Bettina
B
Brichta
Andrea
A
Bachleitner-Hofmann
Thomas
T
Mannhalter
Christine
C
D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011087:Polycythemia Vera / Q000150:complications / Q000453:epidemiology / Q000235:genetics; D011516:Prothrombin / Q000235:genetics*; D013920:Thrombocythemia, Essential / Q000150:complications / Q000453:epidemiology / Q000235:genetics; D013927:Thrombosis / Q000209:etiology / Q000235:genetics*
D011516:Prothrombin