Prevalence of genosubtypes (PorA types) of serogroup B invasive meningococcus in the north of Spain from 2000 to 2003.
The composition of new vaccines against Neisseria meningitidis serogroup B is based on differences in the variable regions VR1 and VR2 of the class 1 outer-membrane protein (PorA) of meningococci. Genosubtyping of 96 N. meningitidis B isolates from blood or cerebrospinal fluid from 2000 to 2003 in the north of Spain allowed characterization of all the strains. Twenty-six genosubtypes or distinct PorA types were obtained. The most prevalent were P1.5-1, 10-8 (20 strains), P1.19, 15 (14 strains), P1.22, 9 (11 strains) and P1.5, 2 (nine strains), while 17 genosubtypes were represented by only one or two strains. The wide diversity of genosubtypes observed and their differences compared with those found in other regions reveals the difficulty in designing a useful outer-membrane vesicle vaccine applicable to different regions of the world.
Vicente
Diego
D
Microbiology Department, Hospital Donostia and Basque Country Meningococcal Reference Centre, Paseo Dr Beguiristain s/n, 20014 San Sebastián (Gipuzkoa), Spain 2Microbiology Laboratory, Hospital Txagorritxu, Vitoria, Spain 3Microbiology Laboratory, Hospital Galdácano, Galdácano, Spain 4Microbiology Department, Hospital Basurto, Bilbao, Spain.
Esnal
Olatz
O
Microbiology Department, Hospital Donostia and Basque Country Meningococcal Reference Centre, Paseo Dr Beguiristain s/n, 20014 San Sebastián (Gipuzkoa), Spain 2Microbiology Laboratory, Hospital Txagorritxu, Vitoria, Spain 3Microbiology Laboratory, Hospital Galdácano, Galdácano, Spain 4Microbiology Department, Hospital Basurto, Bilbao, Spain.
Michaus
Lourdes
L
Microbiology Department, Hospital Donostia and Basque Country Meningococcal Reference Centre, Paseo Dr Beguiristain s/n, 20014 San Sebastián (Gipuzkoa), Spain 2Microbiology Laboratory, Hospital Txagorritxu, Vitoria, Spain 3Microbiology Laboratory, Hospital Galdácano, Galdácano, Spain 4Microbiology Department, Hospital Basurto, Bilbao, Spain.
López de Goicoechea
Maria José
MJ
Microbiology Department, Hospital Donostia and Basque Country Meningococcal Reference Centre, Paseo Dr Beguiristain s/n, 20014 San Sebastián (Gipuzkoa), Spain 2Microbiology Laboratory, Hospital Txagorritxu, Vitoria, Spain 3Microbiology Laboratory, Hospital Galdácano, Galdácano, Spain 4Microbiology Department, Hospital Basurto, Bilbao, Spain.
Cisterna
Ramón
R
Microbiology Department, Hospital Donostia and Basque Country Meningococcal Reference Centre, Paseo Dr Beguiristain s/n, 20014 San Sebastián (Gipuzkoa), Spain 2Microbiology Laboratory, Hospital Txagorritxu, Vitoria, Spain 3Microbiology Laboratory, Hospital Galdácano, Galdácano, Spain 4Microbiology Department, Hospital Basurto, Bilbao, Spain.
Pérez-Trallero
Emilio
E
Microbiology Department, Hospital Donostia and Basque Country Meningococcal Reference Centre, Paseo Dr Beguiristain s/n, 20014 San Sebastián (Gipuzkoa), Spain 2Microbiology Laboratory, Hospital Txagorritxu, Vitoria, Spain 3Microbiology Laboratory, Hospital Galdácano, Galdácano, Spain 4Microbiology Department, Hospital Basurto, Bilbao, Spain.
D015373:Bacterial Typing Techniques; D001483:Base Sequence; D004797:Enzyme-Linked Immunosorbent Assay; D005838:Genotype; D006801:Humans; D015994:Incidence; D008585:Meningitis, Meningococcal / Q000175:diagnosis* / Q000453:epidemiology; D009345:Neisseria meningitidis / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D016133:Polymerase Chain Reaction / Q000379:methods; D018272:Porins / Q000235:genetics*; D013030:Spain / Q000453:epidemiology
D018272:Porins; C057699:porin protein, Neisseria