[Genes involved in the relationship between bone and blood vessel MGP, klotho, OPG].
Recent gene deletion experiments in mice have provided important insights into the molecular mechanisms of vascular calcification. Mice lacking Mgp, klotho, and Opg developed diffuse arterial calcification. These findings favor the hypothesis that vascular calcification appears spontaneously in the absence of an inhibitory protein.
Chikuda
Hirotaka
H
Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo.
Kawaguchi
Hiroshi
H