Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane.
A prospective study was performed to determine the effects of the angiostatic compounds anti-hVEGF antibody, TNP-470, endostatin, and anginex on the vascularization and on endometriosis-like lesion formation in the chicken chorioallantoic membrane model. Endometriosis-like lesion formation was significantly impaired after treatment with angiostatic agents, which was associated with decreased vessel densities in the surrounding chorioallantoic membrane and more necrosis in the endometriosis-like lesions.
Nap
Annemiek W
AW
Department of Obstetrics and Gynaecology, Research Institute Growth and Development (GROW), Maastricht University and University Hospital, Maastricht, The Netherlands.
Dunselman
Gerard A J
GA
Griffioen
Arjan W
AW
Mayo
Kevin H
KH
Evers
Johannes L H
JL
Groothuis
Patrick G
PG
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D002642:Chick Embryo; D002645:Chickens; D049033:Chorioallantoic Membrane / Q000098:blood supply* / Q000473:pathology; D003510:Cyclohexanes; D004715:Endometriosis / Q000517:prevention & control*; D043169:Endostatins / Q000494:pharmacology; D005260:Female; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000517:prevention & control; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D012717:Sesquiterpenes / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology
D020533:Angiogenesis Inhibitors; D000906:Antibodies; D003510:Cyclohexanes; D043169:Endostatins; D012717:Sesquiterpenes; D042461:Vascular Endothelial Growth Factor A; D000077609:O-(Chloroacetylcarbamoyl)fumagillol