title: Dietary bioflavonoids induce apoptosis in human leukemia cells.
abstract: Dietary bioflavonoids are secondary metabolites of plants that are known to have a variety of bio-effects, including anti-cancer activity. In this study, we examined the effects of flavonoids on the growth of human leukemia cells and found that certain flavonoids induce apoptosis in a variety of human leukemia cells. The apoptosis induced by bioflavonoids was dose-dependent and was accompanied by a disruption of the mitochondrial transmembrane potential and the activation of caspase. Our data suggests that dietary bioflavonoids may be useful chemotherapeutic reagents for leukemia patients.
authors.affiliation: Department of Developmental Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 154-8535, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Matsui
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kiyokawa
authors.forename: Hisami
authors.initials: H
authors.lastname: Takenouchi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Taguchi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Shiozawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Saito
authors.forename: Wei-Ran
authors.initials: WR
authors.lastname: Tang
authors.forename: Yohko U
authors.initials: YU
authors.lastname: Katagiri
authors.forename: Hajime
authors.initials: H
authors.lastname: Okita
authors.forename: Junichiro
authors.initials: J
authors.lastname: Fujimoto
mesh_terms: D017304:Annexin A5 / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects*; D020169:Caspases / Q000378:metabolism; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D016130:Immunophenotyping; D007938:Leukemia / Q000378:metabolism / Q000473:pathology*; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D017304:Annexin A5; D005419:Flavonoids; D020169:Caspases