[The role of the hormones-cyclases system in the pathogenesis of erosive gastric and duodenal affections].
As a result of a complex survey of 120 patients with erosive gastroduodenal affections, significant abnormalities of the aggressive-protective balance of the mucous coat of the stomach were discovered. In addition to affections of local protection factors, the change of the hormonal status characterized by hypercortisolemia, hyperinsulinemia, hypergastrinemia and increased level of such cyclic nucleotides as cAMP and cGMP was revealed. The dependence of the mucus-producing function, lysozyme activity and acid production on the level of blood hormones was discovered. Alternate dependencies of cortisol, insulin and gastrin levels on cAMP and cGMP levels as well as alternate impact of cAMP and cGMP on acid-producing gastric cells were established.
Belova
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D000262:Adenylyl Cyclases / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D004382:Duodenitis / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism; D004386:Duodenum / Q000473:pathology; D005260:Female; D005755:Gastrins / Q000097:blood; D005756:Gastritis / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism; D006162:Guanylate Cyclase / Q000378:metabolism*; D006728:Hormones / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000473:pathology
D005755:Gastrins; D006728:Hormones; D007328:Insulin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D006152:Cyclic GMP; D006854:Hydrocortisone