title: The efficacy of valnemulin (Econor) in the control of disease caused by experimental infection of calves with Mycoplasma bovis.
abstract: Mycoplasma bovis infection was experimentally induced in groups of six young calves. A further group was uninfected and served as a control. Ten days after infection, medication with either enrofloxacin (Baytril, Bayer) or valnemulin (Econor, Novartis) was instituted via the milk replacer for a further 10 days, after which all calves were killed. Infection resulted in depression, pyrexia, inappetance and prominent respiratory signs. Arthritis occurred in two animals and two (unmedicated) animals died. At post-mortem examination extensive lesions were present in the lungs and M. bovis was re-isolated from infected unmedicated calves' lungs. Medication with either enrofloxacin or valnemulin resulted in a rapid diminution of clinical signs, restoration of appetite and reversal of weight loss. Isolation of Pasteurella multocida from the calves' lungs was suppressed by both medicaments. Valnemulin resulted in a more rapid reduction of clinical scores and eliminated M. bovis from the lungs more effectively than enrofloxacin.
authors.affiliation: Veterinary Medical Research Institute of Hungarian Academy of Science, Hungária Krt 21, Budapest, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Stipkovits
authors.forename: P H
authors.initials: PH
authors.lastname: Ripley
authors.forename: M
authors.initials: M
authors.lastname: Tenk
authors.forename: R
authors.initials: R
authors.lastname: Glávits
authors.forename: T
authors.initials: T
authors.lastname: Molnár
authors.forename: L
authors.initials: L
authors.lastname: Fodor
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004224:Diterpenes / Q000627:therapeutic use*; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000627:therapeutic use; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D045682:Mycoplasma bovis / Q000187:drug effects*; D015363:Quinolones / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D024841:Fluoroquinolones; D015363:Quinolones; C117845:valnemulin; D000077422:Enrofloxacin