[The possible novel treatment of achondroplasia, C-type natriuretic peptide (CNP)].
C-type natiruetic peptide (CNP) showed a potent effect on the elongation of the tibial organ culture system. CNP also corrected the dwarfing phenotype of the CNP knockout mice. These results suggest that CNP is the novel promoter of the endochondral ossification, and that CNP/GC-B activation is possible target of the treatment of the achondroplasia.
Komatsu
Yasato
Y
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine.
Yasoda
Akihiro
A
Chusho
Hideki
H
Nakao
Kazuwa
K