[Ceruloplasmin level of patients with liver disease in China].
OBJECTIVE
To find out the degree of overlap of ceruloplasmin concentration in patients presenting with liver disease, providing scientific evidences for the diagnosis and differential diagnosis of Wilson's disease (WD).


METHODS
Measuring the serum ceruloplasmin concentration of patients presenting with liver diseases, all data were statistically analyzed with SPSS12 for Windows.


RESULTS
The average serum ceruloplasmin concentration of patients with WD was (93.9 +/- 98.1) mg/L, which was significantly lower than patients with non WD. The ceruloplasmin concentration of 72.7% of patients with WD was less than 100 mg/L, and that of 42.9% of patients with WD was less than 50 mg/L, but the ceruloplasmin concentration of 9.1% of patients with WD was more than 210 mg/L. The average serum ceruloplasmin concentration of patients with acute hepatitis was (398.4 +/- 151.3) mg/L, which was significantly higher than other group. The average serum ceruloplasmin concentration of patients with severe hepatitis was (296.5 +/- 106.5) mg/L, which was significantly lower than other group. The ceruloplasmin concentration of 6.8% of patients with non WD was less than 210 mg/L, the lowest was 28 mg/L.


CONCLUSIONS
There is some degree overlap in ceruloplasmin concentration between WD and other liver disease, WD could not be confirmed or excluded according to ceruloplasmin concentration only.
Yang
Xu
X
Liver Disease Research Center, The Second Xiangya Hospital, Central South University, Changsha 410011, China. yangxu@vip.163.com
Tong
De-Jun
DJ
Liang
Jun
J
Zhang
Yong-Hong
YH
Lei
Jian-Hua
JH
He
Xing-E
XE
He
Gang
G
D002570:Ceruloplasmin / Q000032:analysis*; D002681:China; D003937:Diagnosis, Differential; D006527:Hepatolenticular Degeneration / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis*
D002570:Ceruloplasmin