title: Mean platelet volume in patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  To evaluate mean platelet volume (MPV) in type 2 diabetic versus non-diabetic patients, as well as to investigate the associations between MPV and diabetic complications.
  
  
  METHODS
  This study included 416 patients divided into two groups. Group A comprised 265 type 2 diabetic patients (131 men) with a mean age of 67.4 +/- 9.5 years and a mean diabetes duration of 14.5 +/- 5.7 years. Group B comprised 151 non-diabetic patients (74 men) with a mean age of 68.6 +/- 9.1 years. MPV (blood samples anticoagulated with sodium citrate) was measured in two blood cell counters (Sysmex SF 3000 and Cell-Dyn 3700).
  
  
  RESULTS
  MPV was significantly higher (P = 0.01) in group A (14.2 +/- 2.2 fl) than in group B (7.1 +/- 1.2 fl). In group A MPV was significantly higher (P = 0.043) in patients with retinopathy (15.8 +/- 1.3 fl) than in patients without retinopathy (10.9 +/- 1.1 fl) and also significantly higher (P = 0.044) in patients with microalbuminuria (15.6 +/- 1.2 fl) than in patients without microalbuminuria (10.1 +/- 1.2 fl). No association, however, was found in group A between MPV and age, gender, duration of diabetes, insulin dependency, BMI, HbA1c, coronary artery disease or dyslipidaemia.
  
  
  CONCLUSIONS
  MPV is higher in type 2 diabetic patients than in non-diabetic patients. Among type 2 diabetic patients MPV is higher in those who have microvascular complications (retinopathy or microalbuminuria).
authors.affiliation: Second Department of Internal Medicine, Democritus University of Thrace, Greece. papanasnikos@yahoo.gr
authors.forename: N
authors.initials: N
authors.lastname: Papanas
authors.forename: G
authors.initials: G
authors.lastname: Symeonidis
authors.forename: E
authors.initials: E
authors.lastname: Maltezos
authors.forename: G
authors.initials: G
authors.lastname: Mavridis
authors.forename: E
authors.initials: E
authors.lastname: Karavageli
authors.forename: Th
authors.initials: T
authors.lastname: Vosnakidis
authors.forename: G
authors.initials: G
authors.lastname: Lakasas
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000097:blood; D001792:Blood Platelets / Q000473:pathology*; D016022:Case-Control Studies; D048429:Cell Size; D048909:Diabetes Complications / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged