[Basic fibroblast growth factor in leiomyoma].
Fibroblast growth factor (FGF) is a potent stimulator of collagen and glycosaminoglycan biosynthesis and may play an important role in extracellular matrix (ECM) remodelling. Heparin sulphate was shown to be the major proteoglycan molecule in ECM of leiomyoma. It shows ability to bind some growth factors, including FGF. It was decided to evaluate bFGF presence and binding in leiomyoma tissues. Our results show that bFGF binds to the leiomyoma components of different molecular mass. Most of bFGF was identified in large leiomyoma. We suggest that the level of bFGF in leiomyoma tissue may reflect the intensity of tumour growth.
Wolańska
Małgorzata
M
Zakład Biochemii Lekarskiej Akademii Medycznej w Białymstoku.
Sobolewski
Krzysztof
K
D000328:Adult; D000925:Anticoagulants; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D006493:Heparin; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism* / Q000473:pathology*; D009367:Neoplasm Staging; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000473:pathology*
D000925:Anticoagulants; D016222:Fibroblast Growth Factor 2; D006493:Heparin