Genetic selection for high acute inflammatory response confers resistance to lung carcinogenesis in the mouse.
Mice selected for a high acute inflammatory response (AIRmax) are resistant to chemically induced lung tumorigenesis, whereas the low responders (AIRmin) are susceptible. In urethane-treated mice, anti-inflammatory drugs increased the tumor incidence in AIRmax but not AIRmin mice, and an inverse correlation (P<.001) between the degree of acute inflammatory response (AIR) and lung tumorigenesis was found in an F2 (AIRmax x AIRmin) intercross population. The results provide evidence for the involvement of lung tumor modifier loci in AIR regulation and implicate AIR quantitative trait loci in the inherited predisposition to lung cancer.
Ribeiro
Orlando Garcia
OG
Laboratório de Immunogenética, Instituto Butantan, São Paulo, SP, Brazil.
Cabrera
Wafa Hanna
WH
Maria
Durvanei Augusto
DA
De Franco
Marcelo
M
Massa
Solange
S
Di Pace
Roberto Francisco
RF
de Souza
Vinicius Ricardo Cuña
VR
Starobinas
Nancy
N
Semen
Michel
M
Ibañez
Olga Martinez
OM
D000208:Acute Disease; D000230:Adenocarcinoma / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D007249:Inflammation / Q000235:genetics* / Q000473:pathology; D007958:Leukocyte Count; D008175:Lung Neoplasms / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D019655:Quantitative Trait, Heritable; D012641:Selection, Genetic; D014520:Urethane / Q000633:toxicity
D002273:Carcinogens; D014520:Urethane