title: Effect of concomitant consumption of fish oil and vitamin E on production of inflammatory cytokines in healthy elderly humans.
abstract: A beneficial effect of fish oil in reducing inflammatory and cardiovascular diseases has been suggested. This effect occurs in part through fish oil's inhibition of synthesis of pro-inflammatory cytokines. Epidemiologic studies have shown a link between increased intake of vitamin E in diet and reduced risk of cardiovascular disease. Since pro-inflammatory cytokines have been indicated in pathogenesis of cardiovascular diseases, the current study was designed to determine the effect of concomitant consumption of fish oil and vitamin E on interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha production by peripheral blood mononuclear cells (PBMCs). Healthy elderly subjects consumed fish oil plus different doses of vitamin E for 3 months. The results indicated that, in general, fish oil inhibited production of pro-inflammatory cytokines and vitamin E did not interfere with this effect of fish oil; rather its supplementation might further contribute to the fish oil-induced inhibition of these cytokines, in particular at the 200 mg/d dose.
authors.affiliation: D.V.M., Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. dayong.wu@tufts.edu
authors.forename: Dayong
authors.initials: D
authors.lastname: Wu
authors.forename: Sung Nim
authors.initials: SN
authors.lastname: Han
authors.forename: Mohsen
authors.initials: M
authors.lastname: Meydani
authors.forename: Simin Nikbin
authors.initials: SN
authors.lastname: Meydani
mesh_terms: D000368:Aged; D016207:Cytokines / Q000096:biosynthesis*; D004032:Diet; D004311:Double-Blind Method; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D007249:Inflammation; D007375:Interleukin-1 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D010919:Placebos; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D016207:Cytokines; D005395:Fish Oils; D007375:Interleukin-1; D015850:Interleukin-6; D010919:Placebos; D014409:Tumor Necrosis Factor-alpha; D014810:Vitamin E