title: An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese.
abstract: We report the results of a genome-wide scan conducted in 219 individuals from 34 large multiplex nuclear pedigrees from the northern Han Chinese population at an average resolution of about 10 cM. Nonparametric two-point and multipoint linkage analyses were performed to detect evidence of linkage with type 2 diabetes in this study. On chromosome 1 four regions showed evidence of linkage with type 2 diabetes in northern Han Chinese. Of these regions a marker D1S193 (73 cM) showed evidence of linkage (two-point nonparametric linkage 2.409), and another region (around 190 cM) was a replication of several other studies performed in different ethnic populations. Evidences of linkage have been confirmed by typing additional markers (average distance 1-5 cM) flanking these two positive regions on chromosome 1. We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses.
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, 100005, Beijing, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Zhao
authors.forename: M M
authors.initials: MM
authors.lastname: Xiong
authors.forename: W
authors.initials: W
authors.lastname: Huang
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Zuo
authors.forename: G D
authors.initials: GD
authors.lastname: Wu
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: B Q
authors.initials: BQ
authors.lastname: Qiang
authors.forename: M L
authors.initials: ML
authors.lastname: Zhang
authors.forename: J L
authors.initials: JL
authors.lastname: Chen
authors.forename: W
authors.initials: W
authors.lastname: Ding
authors.forename: W T
authors.initials: WT
authors.lastname: Yuan
authors.forename: H Y
authors.initials: HY
authors.lastname: Xu
authors.forename: L
authors.initials: L
authors.lastname: Jin
authors.forename: Y X
authors.initials: YX
authors.lastname: Li
authors.forename: Q
authors.initials: Q
authors.lastname: Sun
authors.forename: Q Y
authors.initials: QY
authors.lastname: Liu
authors.forename: E
authors.initials: E
authors.lastname: Boerwinkle
authors.forename: F D
authors.initials: FD
authors.lastname: Fang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012984:Software