Metabolism, physiology and stress defense in three aging Ins/IGF-1 mutants of the nematode Caenorhabditis elegans.
The insulin/insulin-like growth factor-1 (Ins/IGF-1) pathway regulates the aging rate of the nematode Caenorhabditis elegans. We describe other features of the three Ins/IGF-1 mutants daf-2, age-1 and aap-1. We show that the investigated Ins/IGF-1 mutants all have a reduced body volume, reduced reproductive capacity, increased ATP concentrations and an elevated stress resistance. We also observed that heat production is lower in these mutants, although the respiration rate was similar or higher compared with wild-type individuals, suggesting a metabolic shift in these mutants.
Houthoofd
Koen
K
Department of Biology, Ghent University, 9000 Ghent, Belgium.
Fidalgo
Manuel A
MA
Hoogewijs
David
D
Braeckman
Bart P
BP
Lenaerts
Isabelle
I
Brys
Kristel
K
Matthijssens
Filip
F
De Vreese
Annemie
A
Van Eygen
Sylvie
S
Muñoz
Manuel J
MJ
Vanfleteren
Jacques R
JR
D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000235:genetics / Q000502:physiology; D000818:Animals; D049628:Body Size; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D018869:Heat-Shock Response; D007328:Insulin / Q000235:genetics*; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D009154:Mutation; D010101:Oxygen Consumption; D012098:Reproduction
D007328:Insulin; D007334:Insulin-Like Growth Factor I; D000255:Adenosine Triphosphate