Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population.
We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2',5'-oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p=0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p=0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.
Hamano
Emi
E
Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, Japan.
Hijikata
Minako
M
Itoyama
Satoru
S
Quy
Tran
T
Phi
Nguyen Chi
NC
Long
Hoang Thuy
HT
Ha
Le Dang
LD
Ban
Vo Van
VV
Matsushita
Ikumi
I
Yanai
Hideki
H
Kirikae
Fumiko
F
Kirikae
Teruo
T
Kuratsuji
Tadatoshi
T
Sasazuki
Takehiko
T
Keicho
Naoto
N
D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D064547:Myxovirus Resistance Proteins; D011110:Polymorphism, Genetic / Q000235:genetics*; D045169:Severe Acute Respiratory Syndrome / Q000235:genetics*; D014744:Vietnam
C579071:MX1 protein, human; D064547:Myxovirus Resistance Proteins; C475085:OAS1 protein, human; D015088:2',5'-Oligoadenylate Synthetase; D019204:GTP-Binding Proteins