title: Syntheses of novel indole lipoic acid derivatives and their antioxidant effects on lipid peroxidation.
abstract: The aim of the study was to examine antioxidant properties of conjugates based on indole and lipoic acid moieties. The design and syntheses of novel indole alpha-lipoic acid derivatives were performed. The antioxidant properties of target compounds were investigated using rat liver microsomal, NADPH-dependent lipid peroxidation inhibition. Some of the target compounds, especially those containing amide linker at position 5 of indole ring, proved to be highly effective in inhibiting lipid peroxidation as compared to alpha-lipoic acid.
authors.affiliation: Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Turkey.
authors.forename: A Selen
authors.initials: AS
authors.lastname: Gurkan
authors.forename: Arzu
authors.initials: A
authors.lastname: Karabay
authors.forename: Zeliha
authors.initials: Z
authors.lastname: Buyukbingol
authors.forename: Adeboye
authors.initials: A
authors.lastname: Adejare
authors.forename: Erdem
authors.initials: E
authors.lastname: Buyukbingol
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000975:Antioxidants; D007211:Indoles; D008063:Thioctic Acid