title: Treatment of wide-necked aneurysms with balloon-expandable polyurethane-covered stentgrafts: experience in an animal model.
abstract: OBJECTIVE
  Endovascular treatment of intracranial wide-necked aneurysms employing stentgrafts might constitute a promising alternative to established neurosurgical or endovascular treatment options. However, there is uncertainity concerning long-term vessel patency and biocompatibility of the covering material used for these stentgrafts. The objective of our study was, therefore, to evaluate in an animal model of wide necked aneurysms, which changes within the parent vessel wall are present after stentgraft placement using polyurethane as the covering material.
  
  
  METHODS
  Wide-necked aneurysms were created in rabbits by distal ligation and intraluminal incubation of the right common carotid artery with elastase. All 10 animals were treated with polyurethane covered stentgrafts. Angiography and histological analyses were performed including immunohistochemical investigations for estimating the proliferation of the intima and possible inflammatory infiltration of the vessel wall after one (n = 5) and three months (n = 5) observation.
  
  
  RESULTS
  Stentgrafts led to a complete and stable aneurysm occlusion in all but one animal in which the stent was initially misplaced. In one animal, the stentgraft was completely occluded as visible both at angiography and on histological examination. Here, old thrombus was found within the stent although the animal was on antiplatelet therapy. The other stentgrafts remained patent and demonstrated only minimal proliferative carrier vessel wall changes and no in-stent stenosis.
  
  
  CONCLUSIONS
  In previous animal models using Dacron covered stentgrafts, a poor short term patency rate due to the limited biocompatibility was found. We found, that Polyurethane seemed to have less adverse effects upon the vessel wall. However, a longer follow-up period is necessary to exclude delayed stenosis of the parent vessels. Stentgrafts may, therefore, play a role in broad based aneurysms, dissecting aneurysms or pseudoaneurysms, however, vessel sacrifice using permanent balloon occlusion may be a safer and better established alternative compared to the use of stentgrafts.
authors.affiliation: Department of Neurosurgery, University Hospital of the University of Technology, Aachen, Germany.
authors.forename: F J
authors.initials: FJ
authors.lastname: Hans
authors.forename: W
authors.initials: W
authors.lastname: Möller-Hartmann
authors.forename: A
authors.initials: A
authors.lastname: Brunn
authors.forename: T
authors.initials: T
authors.lastname: Schmitz-Rode
authors.forename: A
authors.initials: A
authors.lastname: Thron
authors.forename: T
authors.initials: T
authors.lastname: Krings
mesh_terms: D000783:Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D000800:Angioplasty, Balloon; D000818:Animals; D019917:Blood Vessel Prosthesis Implantation; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology; D004195:Disease Models, Animal; D011140:Polyurethanes; D011474:Prosthesis Design; D011817:Rabbits; D011859:Radiography; D015607:Stents
chemical_list: D011140:Polyurethanes