title: Improved outcomes for benign disease with limited pancreatic head resection.
abstract: We sought to determine whether duodenum-preserving pancreatic head resections (DPPHRs) offer improved outcomes for benign disease of the proximal pancreas. A single-cohort study was performed of 86 consecutive patients who underwent DPPHR, extended lateral pancreaticojejunostomy with excavation of the pancreatic head (ELPJ), standard or pylorus-sparing Whipple procedure (WHIP), or distal pancreatectomy (DPR). Aspects of cost, complications (mortality and morbidity), and outcomes were assessed during a follow-up period of 6-63 months (mean, 3 years). Twelve DPPHR and 12 ELPJ procedures were performed for benign lesions or chronic pancreatitis (CP), as were 7 of 30 WHIP procedures and 12 of 16 DPRs. Operative time was significantly less than that for WHIP in ELPJ and DPR procedures. Major complications occurred in 40% of WHIPs and 25% of DPPHRs but only 16% of ELPJs (P < 0.05). Thirty-day mortality was 2 of 30 for WHIP but 0 for all other procedures. Pancreatic or biliary leak occurred in 3 of 30 WHIPs, 3 of 12 DPPHRs, 1 of 16 DPRs, and 0 of 12 ELPJs. New diabetes occurred in 25% of patients who underwent WHIP but only 8% of both DPPHR and ELPJ patients. Full functional recovery was similar for CP patients in both DPPHR and ELPJ. DPPHR and ELPJ are effective surgical approaches to the treatment of benign tumors and CP and are safer than WHIP with lower morbidity and mortality risks. The incidence of new diabetes is less with both ELPJ and DPPHR.
authors.affiliation: Departments of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Gudrun
authors.initials: G
authors.lastname: Aspelund
authors.forename: Mark D
authors.initials: MD
authors.lastname: Topazian
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Lee
authors.forename: Dana K
authors.initials: DK
authors.lastname: Andersen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000714:Anastomosis, Surgical; D001707:Biopsy, Needle; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D010179:Pancreas / Q000473:pathology / Q000601:surgery; D010180:Pancreatectomy / Q000379:methods*; D010182:Pancreatic Diseases / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D010193:Pancreaticojejunostomy / Q000009:adverse effects / Q000379:methods*; D011183:Postoperative Complications / Q000175:diagnosis*; D011336:Probability; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D015996:Survival Rate; D016896:Treatment Outcome