title: Ancient DNA analysis of human neolithic remains found in northeastern Siberia.
abstract: We successfully extracted DNA from a bone sample of a Neolithic skeleton (dated 3,600 +/- 60 years BP) excavated in northeastern Yakutia (east Siberia). Ancient DNA was analyzed by autosomal STRs (short tandem repeats) and by sequencing of the hypervariable region I (HV1) of the mitochondrial DNA (mtDNA) control region. The STR profile, the mitochondrial haplotype, and the haplogroup determined were compared with those of modern Eurasian and Native American populations. The results showed the affinity of this ancient skeleton with both east Siberian/Asian and Native American populations.
authors.affiliation: Laboratoire d'Anthropologie Moléculaire, Institut de Médecine Légale, 67085 Strasbourg, France. fx.ricaut@infonie.fr
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Ricaut
authors.forename: A
authors.initials: A
authors.lastname: Fedoseeva
authors.forename: Christine
authors.initials: C
authors.lastname: Keyser-Tracqui
authors.forename: Eric
authors.initials: E
authors.lastname: Crubézy
authors.forename: Bertrand
authors.initials: B
authors.lastname: Ludes
mesh_terms: D001483:Base Sequence; D001842:Bone and Bones / Q000737:chemistry*; D004247:DNA / Q000235:genetics*; D017931:DNA Primers; D004272:DNA, Mitochondrial / Q000235:genetics; D005580:Fossils; D005787:Gene Frequency; D005843:Geography; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic; D011157:Population Dynamics; D017422:Sequence Analysis, DNA; D012800:Siberia; D020080:Tandem Repeat Sequences / Q000235:genetics
chemical_list: D017931:DNA Primers; D004272:DNA, Mitochondrial; D004247:DNA