title: Mutation of the prothrombin gene and thrombotic events in patients with polycythemia vera or essential thrombocythemia: a cohort study.
abstract: The association between a prothrombin mutation and the risk of thrombosis was analyzed in 214 patients with polycythemia vera or essential thrombocythemia. The rate for venous thrombotic events was 14.7/100 patient-years in patients with the prothrombin mutation compared to 0.8 in patients without the mutation (rate ratio 17.5).
authors.forename: Heinz
authors.initials: H
authors.lastname: Gisslinger
authors.forename: Marcus
authors.initials: M
authors.lastname: Müllner
authors.forename: Ingrid
authors.initials: I
authors.lastname: Pabinger
authors.forename: Navide
authors.initials: N
authors.lastname: Heis-Vahidi-Fard
authors.forename: Bettina
authors.initials: B
authors.lastname: Gisslinger
authors.forename: Andrea
authors.initials: A
authors.lastname: Brichta
authors.forename: Thomas
authors.initials: T
authors.lastname: Bachleitner-Hofmann
authors.forename: Christine
authors.initials: C
authors.lastname: Mannhalter
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011087:Polycythemia Vera / Q000150:complications / Q000453:epidemiology / Q000235:genetics; D011516:Prothrombin / Q000235:genetics*; D013920:Thrombocythemia, Essential / Q000150:complications / Q000453:epidemiology / Q000235:genetics; D013927:Thrombosis / Q000209:etiology / Q000235:genetics*
chemical_list: D011516:Prothrombin