title: The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study.
abstract: Better knowledge of the preclinical phase of Alzheimer's disease would be an important advance to allow earlier treatment of this ominous disease. This prodromal period was investigated in the Paquid cohort by analysing change in cognitive performances at five time points over a 9 year period. Neuropsychological measures including global cognitive functioning (Mini-Mental State Examination), visuo-spatial memory (Benton Visual Retention Test), verbal fluency (Isaacs Set Test) and abstract thinking (Wechsler Similarities Test) were assessed in 215 future Alzheimer's disease subjects and 1050 individuals without dementia. The results showed that cognitive performances of the pre-morbid subjects at baseline were already lower than those of individuals without dementia (1.4 points less on the Mini-Mental State Examination; 1.8 points less on the Benton Visual Retention Test; 4 points less on the Isaacs Set Test and 0.8 points less on the Wechsler Similarities Test). For some neuropsychological tests, an acceleration of the decline occurred approximately 3 years before the diagnosis and, for each test, the course of decline was modulated by education level. These findings show that abnormally low performances can be evidenced 9 years before the clinical diagnosis of Alzheimer's disease in several domains of cognition beyond memory and that cognitive change over time can be influenced by education.
authors.affiliation: INSERM (Institut National de la Santé et de la Recherche Médicale) Unit 593, Bordeaux, France. helene.amieva@isped.u-bordeaux2.fr
authors.forename: Hélène
authors.initials: H
authors.lastname: Amieva
authors.forename: Hélène
authors.initials: H
authors.lastname: Jacqmin-Gadda
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Orgogozo
authors.forename: Nicolas
authors.initials: N
authors.lastname: Le Carret
authors.forename: Catherine
authors.initials: C
authors.lastname: Helmer
authors.forename: Luc
authors.initials: L
authors.lastname: Letenneur
authors.forename: Pascale
authors.initials: P
authors.lastname: Barberger-Gateau
authors.forename: Colette
authors.initials: C
authors.lastname: Fabrigoule
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology*; D003072:Cognition Disorders / Q000503:physiopathology / Q000523:psychology*; D018450:Disease Progression; D042241:Early Diagnosis; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies