Acaricidal activity of active constituent isolated in Chamaecyparis obtusa leaves against Dermatophagoides spp.
Acaricidal activities of materials derived from Chamaecyparis obtusa leaves against Dermatophagoides farinae and Dermatophagoides pteronyssinus were examined using the dry film method and compared with that of commercial benzyl benzoate and N,N-diethyl-m-toluamide (DEET). The active constituent of the C. obtusa leaves was identified as beta-thujaplicin (C10H12(O2)) by spectroscopic analyses. Responses varied with dose. On the basis of a 24 h LC50 value, acaricidal activity against D. farinaewas more pronounced with beta-thujaplicin (72.2 mg/m2) than benzyl benzoate (89.9 mg/m2) and DEET (377 mg/m2). Acaricidal activity against D. pteronyssinus was more pronounced in beta-thujaplicin (62.1 mg/m2) than benzyl benzoate (72.4 mg/m2) and DEET (193 mg/m2). These results indicate that acaricidal activity of C. obtusa leaves likely results from by beta-thujaplicin. Beta-thujaplicin merits further study as potential house dust mite control agents or lead compounds.
Jang
Young-Su
YS
Research Center for Industrial Development of Biofood Materials, Center for Agricultural Science & Technology, College of Agriculture & Life Science, Chonbuk National University, Chonju 561-756, Korea.
Lee
Chi-Hoon
CH
Kim
Moo-Key
MK
Kim
Jeong-Hak
JH
Lee
Sang-Hyun
SH
Lee
Hoi-Seon
HS
D001565:Benzoates; D003671:DEET; D008401:Gas Chromatography-Mass Spectrometry; D007306:Insecticides; D000432:Methanol; D039821:Monoterpenes / Q000032:analysis; D010936:Plant Extracts; D018515:Plant Leaves / Q000737:chemistry*; D039981:Pyroglyphidae; D013983:Tick Control / Q000379:methods; D064028:Tracheophyta / Q000737:chemistry*; D014334:Tropolone / Q000031:analogs & derivatives* / Q000032:analysis
D001565:Benzoates; D007306:Insecticides; D039821:Monoterpenes; D010936:Plant Extracts; D003671:DEET; D014334:Tropolone; C006723:benzyl benzoate; C009479:beta-thujaplicin; D000432:Methanol