[Healing process of fracture].
Fracture healing consists of a sequence of events beginning with inflammation, followed by repair of the damaged tissue and then remodeling of the newly formed tissue, ultimately restoring the injured bone to its original state. Bone induction is also a sequential cascade of cellular and molecular events that includes chemotaxis, mitosis and differentiation. Several signaling molecules, such as inflammatory cytokines, morphogens and growth factors, are produced during fracture healing and initiate the cascade of critical cellular events of fracture healing. If the fracture healing cascade is disturbed, the fracture does not heal normally, resulting in nonunion.
Kokubu
Takeshi
T
Department of Orthopaedic Surgery, Kobe University School of Medicine.
Matsui
Nobuzou
N
Kurosaka
Masahiro
M
Tsunoda
Masaya
M