Effects of capsinoid on serum and liver lipids in hyperlipidemic rats.
We compared the effects of capsinoid, a non-pungent component, on serum and liver lipids, with that of synthetic capsaicin in hyperlipidemic rats. Male Wistar rats of 9 wk old were divided into 4 groups: a control group receiving a high-fat diet containing 1% cholesterol, and capsaicin, capsinoid-I and capsinoid-II groups supplemented with 0.1 mmol of N-pelargonylvanillylamide (synthetic capsaicin), and 0.1 mmol and 1.0 mmol of capsinoid (capsiate: dihydrocapsiate=63 : 37) per kg of control diet, respectively. All groups were pair-fed for 4 wk. Compared with the control group, serum lipid levels in both capsinoid groups and liver lipid contents in the capsinoid-II group showed the same reduction as that of the capsaicin group. In the capsaicin and capsinoid-I groups, fatty acid synthase (FAS) activities were lower and hepatic triacylglycerol lipase (HTGL) [EC 3.1.1.3] activities tended to be higher than those of control group. Lipoprotein lipase (LPL) [EC 3.1.1.34] activity in adipose tissue was higher in the capsaicin and capsinoid-II groups than in the control group. These results showed that capsinoid can improve serum and liver lipid metabolism comparable to synthetic capsaicin.
Tani
Yumiko
Y
Faculty of Home Economics, The Nagoya Women's University, Mizuho-ku, Nagoya 467-0003, Japan. tani@nagoya-wu.ac.jp
Fujioka
Toshiaki
T
Sumioka
Miyuki
M
Furuichi
Yukio
Y
Hamada
Hiroki
H
Watanabe
Tatsuo
T
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000201:enzymology; D000818:Animals; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004041:Dietary Fats / Q000008:administration & dosage; D064429:Fatty Acid Synthases / Q000378:metabolism; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism*; D008049:Lipase / Q000378:metabolism; D008055:Lipids / Q000032:analysis* / Q000097:blood*; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000737:chemistry* / Q000201:enzymology; D008297:Male; D009929:Organ Size; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain
D004041:Dietary Fats; D008055:Lipids; D012333:RNA, Messenger; D064429:Fatty Acid Synthases; D008049:Lipase; D008071:Lipoprotein Lipase; C470213:capsiate; D002211:Capsaicin