The protein tyrosine kinase-dependent pathway mediates the effect of K intake on renal K secretion.
Dietary K intake plays an important role in the regulation of K secretion: a decrease stimulates and an increase suppresses kidney expression of protein tyrosine kinase (PTK), which plays a role in regulating Kir1.1 (ROMK), which is responsible for K secretion in the cortical collecting duct (CCD) and K recycling in the thick ascending limb. Tyrosine phosphorylation of ROMK channels increases with low dietary K and decreases with high dietary K. Moreover, stimulation of tyrosine phosphorylation of ROMK1 enhances ROMK1 internalization and reduces the K channel number in the cell surface in the CCD.
Lin
Dao-Hong
DH
Department of Pharmacology, New York Medical College, Valhalla, New York, USA.
Sterling
Hyacinth
H
Wang
Wen-Hui
WH
D000818:Animals; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*
C086989:KCNJ1 protein, human; D024661:Potassium Channels, Inwardly Rectifying; D011505:Protein-Tyrosine Kinases; D011188:Potassium