title: Catechol-O-methyltransferase and monoamine oxidase B genes and susceptibility to sporadic Parkinson's disease in a Polish population.
abstract: Recent reports have proved that genetic factors play a role in the pathogenesis of sporadic Parkinson's disease (PD). It has been suggested that polymorphisms in monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) might increase the risk of PD. A total of 210 Polish patients with sporadic PD and 152 healthy controls were studied. The MAOB and COMT polymorphisms were identified using the polymerase chain reaction-restriction fragment length polymorphism method. The MAOB allele and genotype frequencies in PD patients did not differ significantly from the controls. A statistically lower frequency of the COMTLL genotype in patients with parkinsonism was found. The combined haplotype of the MAOB G (G/G) and COMTHL genotype showed a fourfold increase (p < 0.05) in the risk of PD in female patients in this Polish population.
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Białecka
authors.forename: Marek
authors.initials: M
authors.lastname: Droździk
authors.forename: Krystyna
authors.initials: K
authors.lastname: Honczarenko
authors.forename: Barbara
authors.initials: B
authors.lastname: Gawrońska-Szklarz
authors.forename: Jan
authors.initials: J
authors.lastname: Stankiewicz
authors.forename: Ewa
authors.initials: E
authors.lastname: Dabrowska
authors.forename: Maciej
authors.initials: M
authors.lastname: Kubisiak
authors.forename: Gabriela
authors.initials: G
authors.lastname: Kłodowska-Duda
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Opala
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D011044:Poland; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012737:Sex Factors
chemical_list: D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase