title: [Infectious complications in using mofetil micofenolate in patients with renal allotransplant].
abstract: OBJECTIVE
  To study infectious complications in renal transplant recipients receiving mycophenolate mofetil (MMF) for prevention of acute transplant rejection or treatment of chronic allograft nephropathy (CAN).
  
  
  METHODS
  A group of renal transplant recipients (n=47) receiving 1.0-2.0 g/day MMF with cyclosporine A (CsA) and steroids as maintaining immunosuppression was compared to a group (n=47) taking triple immunosuppressive therapy which included azathioprine (Aza). Separate group of patients (n=9) received MMF for treatment of CAN. In all groups etiology and incidence of infections were evaluated.
  
  
  RESULTS
  During 2 years various posttransplant infections developed in 72.3% patients on MMF and 93.6% on Aza. The incidence of viral infections was 53.2% in MMF and 59.6% in Aza group, the incidence of bacterial infection--55.3 and 70.2%, respectively. Among 9 recipients with CAN the infections occurred in five. There were two cases of active tuberculosis in Aza group, one--in MMF group and one in patients with CAN.
  
  
  CONCLUSIONS
  We suggest that MMF in the dose 1-2 g/day does not increase infection rates in renal transplant recipients comparing Aza.
authors.forename: E I
authors.initials: EI
authors.lastname: Prokopenko
authors.forename: E O
authors.initials: EO
authors.lastname: Shcherbakova
authors.forename: A V
authors.initials: AV
authors.lastname: Vatazin
authors.forename: E E
authors.initials: EE
authors.lastname: Kruglov
authors.forename: S A
authors.initials: SA
authors.lastname: Pasov
authors.forename: N E
authors.initials: NE
authors.lastname: Budnikova
authors.forename: S G
authors.initials: SG
authors.lastname: Agafonova
authors.forename: E V
authors.initials: EV
authors.lastname: Rusanova
mesh_terms: D000208:Acute Disease; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015994:Incidence; D016030:Kidney Transplantation / Q000379:methods*; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009894:Opportunistic Infections / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid