Expression pattern of TG-interacting factor 2 during mouse development.
TGIF2 is a close homologue of TGIF that functions as a transcriptional corepressor by interaction with transforming growth factor-beta (TGF-beta)-activated Smads. Mutations of TGIF have been found in holoprosencephaly, a genetic disease affecting forebrain and craniofacial developmental. Here we analyzed the expression pattern of TGIF2 during mouse embryogenesis. Expression of TGIF2 transcripts was detected at high level at E12.5 and E15.5 in the nervous system including neopallial cortex, mesencephalon, metencephalon, medulla oblongata, spinal cord, trigeminal ganglion, vestibulocochlear ganglion and dorsal root ganglion. In addition, TGIF2 transcripts could be detected in other tissues including heart, lung, liver, pancreas, kidney, small intestine and nasal cavity. These data indicated that TGIF2 has a wide but well controlled expression pattern during mouse development.
Jin
Lei
L
Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Zhou
Yunhua
Y
Kuang
Chenzhong
C
Lin
Lin
L
Chen
Yan
Y
D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000196:embryology*; D003001:Cloning, Molecular; D017931:DNA Primers; D047108:Embryonic Development; D005260:Female; D005727:Ganglia, Spinal / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D016142:Holoprosencephaly / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics*; D008297:Male; D051379:Mice; D009154:Mutation; D009928:Organ Specificity; D016133:Polymerase Chain Reaction; D012097:Repressor Proteins / Q000235:genetics*
D017931:DNA Primers; D018398:Homeodomain Proteins; D012097:Repressor Proteins; C505201:TG-interacting factor 2, mouse