title: Role of the intracellular receptor domain of gp130 (exon 17) in human inflammatory bowel disease.
abstract: OBJECTIVE
  To study the role of the intracellular receptor domain of gp130 in human inflammatory bowel disease (IBD).
  
  
  METHODS
  We amplified and sequenced the complete exon 17 of the human gp130 gene in 146 patients with IBD. According to clinical and histopathological signs, the 146 patients with IBD were classified as having Crohn's disease (n = 73) or ulcerative colitis (n = 63), or as indeterminate status (n = 10).
  
  
  RESULTS
  No mutations in exon 17 of the gp130 gene could be detected in any of the 146 patients with IBD examined.
  
  
  CONCLUSIONS
  There is no evidence that mutations in exon 17 of the gp130 gene are involved in the pathogenesis of human IBD.
authors.affiliation: Department of Internal Medicine II, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistr 15, D-81377 Munich, Germany. christoph.auernhammer@med.uni-muenchen.de
authors.forename: Christoph-J
authors.initials: CJ
authors.lastname: Auernhammer
authors.forename: Kathrin
authors.initials: K
authors.lastname: Zitzmann
authors.forename: Fabian
authors.initials: F
authors.lastname: Schnitzler
authors.forename: Julia
authors.initials: J
authors.lastname: Seiderer
authors.forename: Peter
authors.initials: P
authors.lastname: Lohse
authors.forename: George
authors.initials: G
authors.lastname: Vlotides
authors.forename: Dieter
authors.initials: D
authors.lastname: Engelhardt
authors.forename: Michael
authors.initials: M
authors.lastname: Sackmann
authors.forename: Burkhard
authors.initials: B
authors.lastname: Goke
authors.forename: Thomas
authors.initials: T
authors.lastname: Ochsenkuhn
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000737:chemistry / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics*; D050822:Cytokine Receptor gp130; D005091:Exons; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics*; D008875:Middle Aged; D017434:Protein Structure, Tertiary
chemical_list: D015703:Antigens, CD; C494199:IL6ST protein, human; D008562:Membrane Glycoproteins; D050822:Cytokine Receptor gp130