[Glutathione S-transferase T1, M1 gene polymorphism in leukemia patients in Shanghai area].
OBJECTIVE
To explore the possible association of polymorphisms of glutathione S-transferases T1, M1 genes and leukemia susceptibility.


METHODS
AS-PCR procedure was applied to determine the GSTs genotypes in a group of leukemia patients (n=61) in Shanghai area. The genotype frequencies in the leukemia patients and normal controls (183 healthy residents in the same city) were compared. Stratification with leukemia types, age and gender was made for further comparison.


RESULTS
The frequencies of GSTT1 0/0 genotype and GSTT1 0/0-GSTM1 0/0 combined genotype were higher in leukemia patients than in controls, and the differences were significant. When stratified with age and gender, this trend still existed in the male ALL patients and in younger ALL patients (age < or = 30).


CONCLUSIONS
Individuals who bear GSTT1 0/0 genotype or GSTT1 0/0-GSTM1 0/0 combined genotypes are more susceptible to leukemia, especially for male and younger carriers.
Zou
Li-li
LL
The 85th PLA Hospital, Shanghai 200052, China. 85zoulili@sohu.com
Lin
Guo-fang
GF
Ma
Qing-wen
QW
Zhang
Dong-sheng
DS
Shen
Jian-hua
JH
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000201:enzymology / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology / Q000235:genetics; D012737:Sex Factors
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1