Effective treatments in the management of brucellosis.
Treatment of uncomplicated brucellosis in humans utilises a variety of anti-biotic combinations, applied to a series of important pathogenetic and clinical parameters. The currently recommended treatment regimens have not been surpassed by newer compounds, and various therapeutic strategies utilising these compounds cannot be adequately evaluated due to the absence of large, multi-centre, multinational trials. The review focuses on the basic principles of brucellosis treatment, the properties of the various regimens used, the results of trials involving them, and the questions raised about the efficacy of these regimens in certain clinical situations.
Pappas
Georgios
G
University Hospital of Ioannina, Internal Medicine Department, 45110, Ioannina, Greece. gpele@otenet.gr
Akritidis
Nikolaos
N
Tsianos
Epameinondas
E
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002002:Brucella / Q000187:drug effects*; D002006:Brucellosis / Q000188:drug therapy* / Q000382:microbiology; D002985:Clinical Protocols; D019468:Disease Management; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans
D000900:Anti-Bacterial Agents