title: [Case of drug-induced pneumonia possibly due to mefloquine (antimalarial drug)].
abstract: A 59-year-old man took mefloquine (antimalarial drug), total dose of 1,000 mg, to prevent malaria before and during traveling to South Africa. Three weeks after the first administration, he was admitted complaining of fever and dyspnea. Chest HRCT showed ground-glass opacities and consolidation in both lung fields. Withdrawal of mefloquine and treatment with corticosteroid resulted in improvement of the clinical findings. From the clinical course, we considered this case to be mefloquine-induced pneumonia. Mefloquine may have caused pulmonary toxicity.
authors.affiliation: Department of Respiratory Medicine, Tenri Hospital.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Inoue
authors.forename: Eisaku
authors.initials: E
authors.lastname: Tanaka
authors.forename: Minoru
authors.initials: M
authors.lastname: Sakuramoto
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Minakuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Maeda
authors.forename: Ko
authors.initials: K
authors.lastname: Maniwa
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Terada
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Goto
authors.forename: Tomoshi
authors.initials: T
authors.lastname: Takeda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Noma
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Taguchi
mesh_terms: D000208:Acute Disease; D000962:Antimalarials / Q000009:adverse effects*; D006801:Humans; D008288:Malaria / Q000517:prevention & control; D008297:Male; D015767:Mefloquine / Q000009:adverse effects*; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage; D020551:Pulse Therapy, Drug; D012131:Respiratory Insufficiency / Q000139:chemically induced; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D011239:Prednisolone; D015767:Mefloquine; D008775:Methylprednisolone