title: [Two cases of testicular tumors with high alpha-fetoprotein levels: a case report].
abstract: Two patients with testicular tumors whose serum alpha-fetoprotein (AFP) persisted to show an abnormally high concentration are reported. Case 1 : A 42-year-old male who had been suffering from chronic hepatitis, underwent left high orchiectomy for a left testicular tumor in 1998. Diagnosis was an authentic stage I seminoma. In 2002, chemotherapy was performed for a metastatic seminoma revealed as a solitary mass in the mediastinum by radiographic studies, and histologically confirmed to be a metastatic seminoma. Although lymph nodes were gradually reduced in size, the serum AFP and transaminase levels remained at an abnormally high concentration. The subfraction profile with lens culinaris hemagglutinin (LCA) revealed elevation of only peak 1 which implied that the chronic hepatitis was due to liver dysfunction. After a 10-month follow-up the levels of both AFP and transaminase decreased, and the patient was disease-free. Case 2: In 2002, a 30-year-old male underwent left high orchiectomy for a left testicular tumor, and histological examination revealed seminoma, immature and mature teratoma, embryonal carcinoma. The serum AFP was elevated to 45 ng/ml. Diagnosis was authentic stage I. After 2 courses of chemotherapy, the serum AFP remained at an abnormally high concentration. However, there were no new lesions. The serum AFP level was not elevated in any of the family members. The subfraction profile with LCA revealed elevation of only peak 1, which implied that there were no viable lesions. After a 24-month follow-up AFP was about 20 ng/ml and the patient was disease-free.
authors.affiliation: Department of Urology, Yokohama City University School of Medicine.
authors.forename: Makoto
authors.initials: M
authors.lastname: Funahashi
authors.forename: Futoshi
authors.initials: F
authors.lastname: Tuchiya
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Makiyama
authors.forename: Shinpei
authors.initials: S
authors.lastname: Sugiura
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Miyoshi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kishida
authors.forename: Takehiko
authors.initials: T
authors.lastname: Ogawa
authors.forename: Hiroji
authors.initials: H
authors.lastname: Uemura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yao
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kubota
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D018236:Carcinoma, Embryonal / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000556:secondary; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009919:Orchiectomy; D018239:Seminoma / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D013724:Teratoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins