Microwave-promoted Suzuki reactions of aryl chlorides in aqueous media.
[reaction: see text] The microwave-promoted Suzuki coupling reaction of aryl chlorides with boronic acids performed in an aqueous media was studied using the air- and moisture-stable catalyst POPd2 (dihydrogen di-mu-chlorodichlorobis(di-tert-butylphosphinito-kappaP)dipalladate (2-)). This catalyst system under microwave conditions (150 degrees C, 15 min) provided coupled products with yields ranging from 64% to 99%. This method tolerated a variety of substituents and sterically hindered substrates.
Miao
Guobin
G
ArQule Inc., 19 Presidential Way, Woburn, Massachusetts 01801, USA. lyu@arqule.com
Ye
Ping
P
Yu
Libing
L
Baldino
Carmen M
CM
D001713:Biphenyl Compounds / Q000138:chemical synthesis*; D001897:Boronic Acids / Q000737:chemistry; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010984:Platinum / Q000737:chemistry; D014867:Water / Q000737:chemistry
D001713:Biphenyl Compounds; D001897:Boronic Acids; D006843:Hydrocarbons, Chlorinated; D009942:Organometallic Compounds; D014867:Water; D010984:Platinum