title: Impairment of skilled forelimb use after ablation of striatal interneurons expressing substance P receptors in rats: an analysis using a pasta matrix reaching task.
abstract: Local injection of substance P (SP)-saporin can cause selective ablation of striatal interneurons expressing SP receptors (SPR). In this study, we evaluated quantitatively the impairment of skilled forelimb use after unilateral ablation of the striatal interneurons using a pasta matrix reaching task in rats. We found a significant decrease of the number of the pasta pieces (uncooked spaghetti) retrieved using the paw of the experimental side contralateral to the ablation, whereas the number of the pasta pieces retrieved using the paw of the intact side increased significantly. These findings, with our previous reports, suggest that the modulation of the cortico-striato-entopeduncular direct pathway by striatal interneurons is important for maintaining normal basal-ganglia control for skilled forelimb movements.
authors.affiliation: Department of Brain Structure, Tokyo Metropolitan Institute for Neuroscience, Fuchu, 183-8526 Tokyo, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Chiken
authors.forename: Hironobu
authors.initials: H
authors.lastname: Tokuno
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000502:physiology* / Q000503:physiopathology; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D005552:Forelimb / Q000294:innervation / Q000502:physiology* / Q000503:physiopathology; D007395:Interneurons / Q000378:metabolism / Q000502:physiology*; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology* / Q000503:physiopathology; D009498:Neurotoxins; D051381:Rats; D017208:Rats, Wistar; D018040:Receptors, Neurokinin-1 / Q000819:agonists / Q000096:biosynthesis*; D013373:Substance P / Q000378:metabolism
chemical_list: D009498:Neurotoxins; D018040:Receptors, Neurokinin-1; D013373:Substance P