Ocular manifestations in patients with microscopic polyangiitis.
OBJECTIVE
To describe ocular manifestations in patients with microscopic polyangiitis.


METHODS
Two patients with microscopic polyangiitis complained of ocular symptoms and underwent ophthalmologic examinations.


RESULTS
An 83-year-old woman (Case 1) was diagnosed with microscopic polyangiitis, according to the general clinical findings and the presence of perinuclear pattern of antineutrophil cytoplasmic antibodies (P-ANCA). She had hypopyon iridocyclitis in the right eye and retinal cotton-wool spots in the left eye. The patient was treated with oral prednisolone and subconjunctival betamethasone. The hypopyon iridocyclitis and retinal cotton-wool spots responded. A 79-year-old man (Case 2) had bilateral scleritis. The diagnosis of microscopic polyangiitis was made based on general clinical findings and the presence of P-ANCA. Scleritis was reduced after corticosteroid treatment.


CONCLUSIONS
Ophthalmologists should be aware that hypopyon iridocyclitis, cotton-wool spot, and scleritis could occur in patients with microscopic polyangiitis.
Mihara
M
M
Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama - Japan. ophthal@ms.toyama-mpu.ac.jp
Hayasaka
S
S
Watanabe
K
K
Kitagawa
K
K
Hayasaka
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D000869:Anterior Eye Segment / Q000187:drug effects / Q000473:pathology*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D001623:Betamethasone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015863:Iridocyclitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012164:Retinal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D015423:Scleritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013492:Suppuration
D019268:Antibodies, Antineutrophil Cytoplasmic; D005938:Glucocorticoids; D001623:Betamethasone; D011239:Prednisolone