Combinatorial libraries - from solution to 2D microarrays.
Enzymatic modifications of split and mix libraries were followed by "pulling down" onto a 2-dimensional DNA microarray, via PNA tagging; this allowed complete library interrogation of all members of the split and mix library.
Díaz-Mochón
Juan José
JJ
School of Chemistry, University of Southampton, Southampton, UK SO17 1BJ.
Bialy
Laurent
L
Keinicke
Lise
L
Bradley
Mark
M
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D020411:Oligonucleotide Array Sequence Analysis; D010447:Peptide Hydrolases / Q000737:chemistry; D020135:Peptide Nucleic Acids; D016315:Proto-Oncogene Proteins c-abl / Q000737:chemistry; D012996:Solutions / Q000737:chemistry
D020135:Peptide Nucleic Acids; D012996:Solutions; D016315:Proto-Oncogene Proteins c-abl; D010447:Peptide Hydrolases