[Significance of biochemical markers for bone metabolism in the treatment of parathyroid and thyroid disorders].
Biochemical markers for bone metabolism has been established as a sensitive and reliable predictor for future changes in bone mass, since good correlations are found between early changes in bone markers and late changes in bone mass. When hyperparathyroidism and hyperthyroidism are treated, a prompt decrease is found in bone resorption markers but not in bone formation markers. The decrease of bone formation markers occurs from 3 months to as long as 1 year after a sharp decline of bone resorption marker. Bone markers now used in clinical practice are sensitive and reliable enough to detect even a subtle change in bone metabolism.
Inaba
M
M
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine.