DNA damage-induced cohesion.
The protein complex Cohesin, forming protein-links that hold sister chromatids together, is at the heart of chromatid cohesion. Cohesion is important both for correct chromosome segregation and double-strand break (DSB) repair, making Cohesin central for the maintenance of genome stability. Until now, establishment of Cohesin links between chromatids has been shown to occur during DNA replication only. Recently it was however observed that in cells arrested in G2/M, DSB induction not only elicits chromosomal recruitment of Cohesin, but also formation of chromatid cohesion. The establishment of cohesion outside the period of replication opens a new field of investigation. Here we present results further supporting the formation of sister chromatid cohesion in response to DNA damage, and propose a model of how damage-induced cohesion could contribute to the linkage of chromatids during normal cell cycle progression.
Ström
Lena
L
Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
Sjögren
Camilla
C
D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000737:chemistry*; D002455:Cell Division; D002842:Chromatids / Q000737:chemistry; D002843:Chromatin / Q000737:chemistry; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry*; D020090:Chromosome Segregation; D004249:DNA Damage; D004260:DNA Repair; D005656:Fungal Proteins / Q000737:chemistry*; D016195:G2 Phase; D016678:Genome; D008954:Models, Biological; D009687:Nuclear Proteins / Q000737:chemistry*; D051818:Replication Protein C / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D000097722:Cohesins
D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D005656:Fungal Proteins; D009687:Nuclear Proteins; D051818:Replication Protein C; D000097722:Cohesins