Drug-induced immune cytopenias.
Drugs can induce thrombocytopenia by several mechanisms, including marrow suppression and destruction of platelets in the peripheral blood by non-immune and immune mechanisms. We will review here current understanding of the immune mechanisms by which drugs promote immune-mediated platelet destruction resulting in thrombocytopenia.
Aster
Richard H
RH
Medical College of Wisconsin, Milwaukee, WI 53201-2178, USA. rhaster@bcsew.edu
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001792:Blood Platelets / Q000187:drug effects / Q000276:immunology; D004342:Drug Hypersensitivity / Q000276:immunology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology
D001323:Autoantibodies