The dynamics of histone H1 function in chromatin.
Over 80% of the nucleosomes in chromatin contain histone H1, a protein family known to affect the structure and activity of chromatin. Genetic studies and in vivo imaging experiments are changing the traditional view of H1 function and mechanism of action. H1 variants are partially redundant, mobile molecules that interact with nucleosomes as members of a dynamic protein network and serve as fine tuners of chromatin function.
Bustin
Michael
M
Protein Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. bustin@helix.nih.gov
Catez
Frédéric
F
Lim
Jae-Hwan
JH
D000818:Animals; D002843:Chromatin / Q000737:chemistry* / Q000502:physiology; D004247:DNA / Q000737:chemistry; D004261:DNA Replication; D006657:Histones / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009707:Nucleosomes / Q000378:metabolism; D010641:Phenotype; D010940:Plant Proteins / Q000737:chemistry
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D010940:Plant Proteins; D004247:DNA