Preservation of hippocampal volume throughout adulthood in healthy men and women.
To address controversies regarding the effect of age on the hippocampus, volumes of hippocampus and a comparison structure, temporal cortex, were measured on magnetic resonance imaging (MRI) in 84 healthy men and 44 healthy women (20-85 years). Neither men nor women showed significant correlations between hippocampal volumes and age, despite significant age-related decline in temporal volumes. Absence of hippocampus age relationships endured when restricting analyses to older individuals (> or =50 years) and considering menopause and hormone replacement therapy.
Sullivan
Edith V
EV
Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305 5723, USA. edie@stanford.edu
Marsh
Laura
L
Pfefferbaum
Adolf
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013223:Statistics as Topic / Q000379:methods; D013702:Temporal Lobe / Q000033:anatomy & histology*