title: Characteristic beta-globin gene cluster haplotypes of Evenkis and Oroqens in north China.
abstract: Haplotype frequencies of the beta-globin gene cluster were estimated for 114 Evenkis and 81 Oroqens from northeast China, and their characteristics were compared with those in Japanese, Koreans, and three Colombian Amerindian groups of South America (Wayuu, Kamsa, and Inga tribes). A major 5' subhaplotype (5' to the delta-globin gene) was + - - - - in Evenkis, whereas + - - - -, - + + - +, and - + - + + were the major subhaplotypes in Oroqens. One possible candidate for an ancestral 5' subhaplotype, - - - - -, was found in one Evenki (0.5%) and three Oroqen chromosomes (2.0%). They were observed as heterozygous forms for + ---- and -----. Major haplotypes were +-----+, + -----+-, and + - - - - + + in Evenkis, whereas they were +-----+,-++-+-+, +----+-, and -+-++-+ in Oroqens. The lowest Nei's genetic distance values of Evenkis or Oroqens based on the 5' subhaplotype frequency distributions were observed in relation to the Wayuu or Koreans, respectively, but those of Evenkis and Oroqens based on the haplotype frequency distributions were found in relation to Koreans.
authors.affiliation: Laboratory of Biology, Naruto University of Education, Tokushima 772-8502, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Shimizu
authors.forename: Azusa
authors.initials: A
authors.lastname: Marubayashi
authors.forename: Kozue
authors.initials: K
authors.lastname: Tokimasa
authors.forename: Shinji
authors.initials: S
authors.lastname: Harihara
authors.forename: Keiichi
authors.initials: K
authors.lastname: Omoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Imanishi
authors.forename: Luping
authors.initials: L
authors.lastname: Hao
authors.forename: Feng
authors.initials: F
authors.lastname: Jin
mesh_terms: D044466:Asian People / Q000235:genetics*; D001609:Beta-Globulins / Q000235:genetics*; D002681:China; D016000:Cluster Analysis; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D005810:Multigene Family; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D001609:Beta-Globulins