Evolution of serum alpha-tocopherol in the postprandial and postabsorptive phases in type 1 diabetes mellitus.
Blood glucose, lipids, alpha-tocopherol, and malondialdehyde were monitored in type 1 diabetes mellitus patients for 8 hours after a standard fat-rich breakfast and lunch. Although glucose and triglycerides increased, alpha-tocopherol decreased and malondialdehyde increased in the postprandial phase. In the postabsorptive phase values returned to fasting levels. These results point to the possible relevance of postprandial alpha-tocopherol depletion and lipid peroxidation to an increased cardiovascular risk in these patients.
Manuel-y-Keenoy
Begoña
B
University of Antwerp (UA) campus Drie Eiken, Metabolic Research Unit (AMRU) T4.37, Universiteitsplein 1, B-2610 Wilrijk-Antwerp, Belgium. begona.manuelykeenoy@ua.ac.be
Van Campenhout
Ann
A
Vertommen
Jan
J
Van Gaal
Luc
L
De Leeuw
Ivo
I
D000042:Absorption; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D005502:Food; D006801:Humans; D007700:Kinetics; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood*
D001786:Blood Glucose; D008055:Lipids; D014280:Triglycerides; D008315:Malondialdehyde; D024502:alpha-Tocopherol