Genetic mouse models of essential tremor: are they essential?
The causative genes for essential tremor (ET), one of the most common genetic neurological disorders, have eluded scientists despite intensive search. Two gene loci linked to ET, one on chromosome 3q13 and another on chromosome 2p24.1, have been identified, and a missense mutation in the HS1-BP3 gene on the 2p has been suggested as the cause of the disorder in about 10% of American ET patients. Therefore, the genetic basis for the vast majority of familial ET is still unknown. In this issue of the JCI, the gene coding for the gamma-aminobutyric acidA (GABA(A)) receptor alpha1 subunit is suggested as a potential candidate gene for ET, as mice lacking the gene express a phenotype that overlaps with some clinical characteristics of the human condition.
Jankovic
Joseph
J
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA. josephj@bcm.tmc.edu
Noebels
Jeffrey L
JL
D000818:Animals; D004195:Disease Models, Animal; D020329:Essential Tremor / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D021122:Protein Subunits / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism; D013569:Synapses / Q000502:physiology
D021122:Protein Subunits; D011963:Receptors, GABA-A