An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese.
We report the results of a genome-wide scan conducted in 219 individuals from 34 large multiplex nuclear pedigrees from the northern Han Chinese population at an average resolution of about 10 cM. Nonparametric two-point and multipoint linkage analyses were performed to detect evidence of linkage with type 2 diabetes in this study. On chromosome 1 four regions showed evidence of linkage with type 2 diabetes in northern Han Chinese. Of these regions a marker D1S193 (73 cM) showed evidence of linkage (two-point nonparametric linkage 2.409), and another region (around 190 cM) was a replication of several other studies performed in different ethnic populations. Evidences of linkage have been confirmed by typing additional markers (average distance 1-5 cM) flanking these two positive regions on chromosome 1. We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses.
Zhao
J Y
JY
Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, 100005, Beijing, China.
Xiong
M M
MM
Huang
W
W
Wang
H
H
Zuo
J
J
Wu
G D
GD
Chen
Z
Z
Qiang
B Q
BQ
Zhang
M L
ML
Chen
J L
JL
Ding
W
W
Yuan
W T
WT
Xu
H Y
HY
Jin
L
L
Li
Y X
YX
Sun
Q
Q
Liu
Q Y
QY
Boerwinkle
E
E
Fang
F D
FD
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012984:Software