title: Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage "in cellulo".
abstract: The synthesis and photophysical characterisation are reported of a series of cationic, neutral and anionic europium and terbium complexes based on structurally related, nonadentate ligands based on the cyclen macrocycle. Each complex incorporates a tetraazatriphenylene moiety and overall absolute emission quantum yields are in the range 15-40% in aerated aqueous media. Dynamic quenching of the lanthanide excited state occurs with electron-rich donors, e.g. iodide, ascorbate and urate, and a mechanistic interpretation is put forward involving an electron transfer process. The cationic lanthanide complexes are taken up by NlH/3T3 cells and tend to localise inside the cell nucleus.
authors.affiliation: Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Poole
authors.forename: Gabriella
authors.initials: G
authors.lastname: Bobba
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Cann
authors.forename: Juan-Carlos
authors.initials: JC
authors.lastname: Frias
authors.forename: David
authors.initials: D
authors.lastname: Parker
authors.forename: Robert D
authors.initials: RD
authors.lastname: Peacock
mesh_terms: D000818:Animals; D007700:Kinetics; D028581:Lanthanoid Series Elements / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells / Q000648:ultrastructure; D010618:Phenanthrolines / Q000737:chemistry* / Q000378:metabolism
chemical_list: D028581:Lanthanoid Series Elements; D010618:Phenanthrolines