Unchain my heart: the scientific foundations of cardiac repair.
In humans, the biological limitations to cardiac regenerative growth create both a clinical imperative--to offset cell death in acute ischemic injury and chronic heart failure--and a clinical opportunity; that is, for using cells, genes, and proteins to rescue cardiac muscle cell number or in other ways promote more efficacious cardiac repair. Recent experimental studies and early-phase clinical trials lend credence to the visionary goal of enhancing cardiac repair as an achievable therapeutic target.
Dimmeler
Stefanie
S
Department of Molecular Cardiology, University of Frankfurt, Frankfurt am Main, Germany. Dimmeler@em.uni-frankfurt.de
Zeiher
Andreas M
AM
Schneider
Michael D
MD
D002465:Cell Movement; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000473:pathology / Q000628:therapy*; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D018919:Neovascularization, Physiologic; D012038:Regeneration / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology