Behavioral and neurochemical repercussions of hippocampal network activity blockade during the neonatal period.
Early destruction of the ventral hippocampus from postnatal day 7 (P7) has been shown to induce behavioral alterations in post-pubertal rats, similar to those observed in models for schizophrenia. Using a single injection of tetanus toxin into the ventral hippocampus at P1, we tested the consequences of an early neonatal activity deprivation (<P7) on behavioral and neurochemical parameters of pre- and post-pubertal rats. We found no significant differences in either behavioral or biochemical pattern, indicating that an early neonate neural activity blockade does not induce behavioral alterations in pre- and post-puberty rats.
Ponten
Henrik
H
Department of Pharmacology, Göteborg University, Sweden.
Sönniksen
Kirsten
K
Abrahamsson
Therése
T
Waters
Nicholas
N
Gustafsson
Bengt
B
Hanse
Eric
E
Groc
Laurent
L
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000254:growth & development* / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D009415:Nerve Net / Q000254:growth & development* / Q000378:metabolism* / Q000503:physiopathology; D009638:Norepinephrine / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012559:Schizophrenia / Q000209:etiology; D012701:Serotonin / Q000378:metabolism; D012741:Sexual Maturation / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D013744:Tetanus Toxin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D013744:Tetanus Toxin; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D004298:Dopamine; D009638:Norepinephrine