title: Two successive pregnancies after ursodeoxycholic acid therapy in a previously infertile woman with antimitochondrial antibody-negative primary biliary cirrhosis.
abstract: OBJECTIVE
  To describe the benefit of ursodeoxycholic acid (UDCA) for the initiation and completion of a successful pregnancy in a previously infertile woman with primary biliary cirrhosis.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A university hospital with relevant departments.
  
  
  METHODS
  A 29-year-old woman with primary biliary cirrhosis and failure to conceive for 6 years.
  
  
  METHODS
  Establishment of diagnosis with a liver biopsy, pretreatment of patient with UDCA before conception, and continuation of UDCA after first trimester until term. UDCA was used in the second pregnancy again after the first trimester.
  
  
  METHODS
  Achievement of a safe conception and full-term pregnancy.
  
  
  RESULTS
  Two consecutive successful pregnancies, a healthy 3,250-g male infant and a healthy 3,000-g female infant. The second conception occurred in a period without the use of UDCA, implicating a latent beneficial effect of either UDCA or the previous pregnancy via some possible immune mechanism.
  
  
  CONCLUSIONS
  Ursodeoxycholic acid could help achieve conception in infertile women with primary biliary cirrhosis. The use of UDCA after the first trimester is shown to be safe in two consecutive pregnancies. Although it cannot be conclusive, the unintentional use of UDCA in the first 20 days after conception did not result in any teratogenicity in the first child.
authors.affiliation: Department of Internal Medicine, Aibü Duzce Medical School, Duzce, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Korkut
authors.forename: Bünyamin
authors.initials: B
authors.lastname: Kisacik
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Akcan
authors.forename: Olcay
authors.initials: O
authors.lastname: Belenli
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Bicik
authors.forename: Oğuz
authors.initials: O
authors.lastname: Yucel
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000378:metabolism; D002756:Cholagogues and Choleretics / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000188:drug therapy*; D008928:Mitochondria / Q000276:immunology; D011247:Pregnancy; D011256:Pregnancy Outcome; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage*
chemical_list: D001323:Autoantibodies; D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid