title: Metalloantimalarials: synthesis and characterization of a novel agent possessing activity against Plasmodium falciparum.
abstract: The synthesis, characterization, and antimalarial potency of an amine-phenol complex of gallium(III), [{1,12-bis(2-hydroxy-3-methoxy-5-(quinolin-3-yl)-benzyl)-1,5,8,12-tetraazadodecane}-gallium(III)]+, [Ga-3-M-5-Quadd]+ (7) is described; a novel agent that targets Plasmodium falciparum strains.
authors.affiliation: Mallinckrodt Institute of Radiology, Washington University Medical School, St. Louis, MO, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Ocheskey
authors.forename: Scott E
authors.initials: SE
authors.lastname: Harpstrite
authors.forename: Anna
authors.initials: A
authors.lastname: Oksman
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Goldberg
authors.forename: Vijay
authors.initials: V
authors.lastname: Sharma
mesh_terms: D000588:Amines / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005708:Gallium / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D021261:Parasitic Sensitivity Tests; D010636:Phenols / Q000737:chemistry / Q000378:metabolism; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development
chemical_list: C517926:((1,12-bis(2-hydroxy-3-methoxy-5-(quinolin-3-yl)-benzyl)-1,5,8,12-tetraazadodecane)-gallium(III))+; D000588:Amines; D000962:Antimalarials; D009942:Organometallic Compounds; D010636:Phenols; D005708:Gallium