title: RecX is involved in antioxidant mechanisms of the radioresistant bacterium Deinococcus radiodurans.
abstract: Deinococcus radiodurans shows remarkable resistance to reactive oxygen species (ROS), generated by irradiation. Disruption of recX (dr1310) in D. radiodurans using targeted mutagenesis method enhanced its ROS scavenging activity, and recX overexpression in this bacterium repressed its antioxidant activity significantly. Further analyses on catalase and superoxide dismutase, two important antioxidant proteins in cells, showed that RecX could repress the induction of antioxidant enzymes, revealing that it negatively regulates the ROS scavenging activity in D. radiodurans.
authors.affiliation: Institute of Nuclear-Agricultural Sciences, Zhejiang University, 310029 Hangzhou, China.
authors.forename: Duohong
authors.initials: D
authors.lastname: Sheng
authors.forename: Guanjun
authors.initials: G
authors.lastname: Gao
authors.forename: Bing
authors.initials: B
authors.lastname: Tian
authors.forename: Zhenjian
authors.initials: Z
authors.lastname: Xu
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zheng
authors.forename: Yuejin
authors.initials: Y
authors.lastname: Hua
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D002374:Catalase / Q000235:genetics / Q000378:metabolism*; D034301:Deinococcus / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000528:radiation effects*; D015964:Gene Expression Regulation, Bacterial; D017382:Reactive Oxygen Species / Q000032:analysis*; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D017382:Reactive Oxygen Species; C430523:RecX protein, Xanthomonas campestris; D002374:Catalase; D013482:Superoxide Dismutase