Hepatitis C infection is not associated with systemic HIV-associated non-Hodgkin's lymphoma: a cohort study.
Immunosuppression induced by the human immunodeficiency virus (HIV) increases the risk of developing non-Hodgkin's lymphoma (NHL). As the hepatitis C virus (HCV) has been implicated in the development of B cell lymphomas, we compared the incidence of systemic NHL during HIV infection compared to HIV and HCV co-infection. Of 5,832 individuals studied during the era of highly active anti-retroviral therapy (HAART), 102 patients were diagnosed with systemic NHL. The incidence of systemic NHL was 6.9 of 10(4) patient years during HIV infection compared to 7.1 of 10(4) patient years during HIV alone (p = 0.9). In this immunocompromised patient population, there was no association between HCV infection and an increased risk of lymphoma.
Waters
Laura
L
Department of HIV Medicine, The Chelsea and Westminster Hospital, London, United Kingdom.
Stebbing
Justin
J
Mandalia
Sundhiya
S
Young
Anne Marie
AM
Nelson
Mark
M
Gazzard
Brian
B
Bower
Mark
M
D015331:Cohort Studies; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D016483:Lymphoma, AIDS-Related / Q000150:complications* / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000453:epidemiology