Effect of preexisting statin use on expression of C-reactive protein, adhesion molecules, interleukin-6, and antioxidized low-density lipoprotein antibody in patients with unstable angina undergoing coronary stenting.
BACKGROUND
Statins are believed to reduce coronary heart disease by mechanisms in addition to their well-known cholesterol lowering effect.


OBJECTIVE
We studied the effect of statins on expression of C-reactive protein (CRP), interleukin-6 (IL-6), adhesion molecules, and antioxidized low-density lipoprotein antibody (anti-oxLDL Ab) in patients with unstable angina (Braunwald class IIb or IIIb) undergoing coronary stenting.


METHODS
Consecutive 50 patients with unstable angina were included in the study. We classified the study subjects as patients using statins (Group A, n=20, men 10, mean age 62 years) and patients not using statins (Group B, n=30, men 15, mean age 60 years).


RESULTS
Baseline levels of inflammatory markers were similar in the two groups. However, 24 h after coronary stenting, serum levels of CRP (2.00 vs. 4.63 mg/l, p < 0.05), intercellular adhesion molecule-1 (ICAM-1) (217 vs. 261 ng/ml, p < 0.01), and anti-oxLDL Ab (8.97 vs. 12.96 U/ml, p < 0.05) were significantly higher in Group B than in Group A. Furthermore, 72 h after coronary stenting, serum levels of CRP (3.00 vs. 5.50 mg/l, p < 0.01) and ICAM-1 (222 vs. 277 ng/ml, p < 0.05) were significantly higher in Group B than in Group A.


CONCLUSIONS
Preexisting statin therapy plays a role in reducing the serum levels of CRP, ICAM-1, and anti-oxLDL Ab after coronary stenting in patients with unstable angina. These data support an anti-inflammatory or plaque-stabilizing effect of statin therapy.
Doo
Young-Cheoul
YC
Division of Cardiology, Department of Internal Medicine, Kang-Dong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea. ycdoo97@yahoo.co.kr
Han
Sang-Jin
SJ
Han
Sung-Woo
SW
Park
Woo-Jung
WJ
Choi
Seung-Hyuk
SH
Cho
Goo-Yeong
GY
Hong
Kyung-Soon
KS
Han
Kyoo-Rok
KR
Lee
Nam-Ho
NH
Oh
Dong-Jin
DJ
Ryu
Kyu-Hyung
KH
Rim
Chong-Yun
CY
Lee
Kwang-Hahk
KH
Lee
Yung
Y
D000789:Angina, Unstable / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis / Q000187:drug effects; D016009:Chi-Square Distribution; D003331:Coronary Vessels / Q000601:surgery; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000187:drug effects; D015850:Interleukin-6 / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D015607:Stents; D013997:Time Factors
D015415:Biomarkers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D015850:Interleukin-6; D008077:Lipoproteins, LDL; C019455:low density lipoprotein inhibitor; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein