title: DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment.
abstract: The authors assessed whether measures of hippocampal water diffusivity at baseline can predict future progression to Alzheimer disease (AD) in amnestic mild cognitive impairment (aMCI). Higher baseline hippocampal diffusivity was associated with a greater risk of progression to AD in aMCI (p = 0.002). Magnetic resonance diffusion-weighted imaging may help identify patients with aMCI who will progress to AD as well as or better than structural MRI measures of hippocampal atrophy.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: K
authors.initials: K
authors.lastname: Kantarci
authors.forename: R C
authors.initials: RC
authors.lastname: Petersen
authors.forename: B F
authors.initials: BF
authors.lastname: Boeve
authors.forename: D S
authors.initials: DS
authors.lastname: Knopman
authors.forename: S D
authors.initials: SD
authors.lastname: Weigand
authors.forename: P C
authors.initials: PC
authors.lastname: O'Brien
authors.forename: M M
authors.initials: MM
authors.lastname: Shiung
authors.forename: G E
authors.initials: GE
authors.lastname: Smith
authors.forename: R J
authors.initials: RJ
authors.lastname: Ivnik
authors.forename: E G
authors.initials: EG
authors.lastname: Tangalos
authors.forename: C R
authors.initials: CR
authors.lastname: Jack
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000473:pathology; D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology; D000647:Amnesia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D015415:Biomarkers; D001834:Body Water / Q000378:metabolism; D003072:Cognition Disorders / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D006624:Hippocampus / Q000737:chemistry / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D015415:Biomarkers