The US smallpox vaccination program: a review of a large modern era smallpox vaccination implementation program.
We describe the US experience with a large-scale smallpox vaccination program in the modern era and quantify the anticipated and unanticipated local and systemic side-effects of smallpox vaccination. In addition, we review unexpected issues, such as the development of myopericarditis discovered during the implementation of this program. These results constitute the largest dataset of a vaccinia vaccination program utilizing calf-lymph derived New York City Board of Health strain vaccine (Dryvax, Wyeth) since the 1970s. These results should inform current and future vaccinia vaccination programs and provide a historical rate of complications against which candidate vaccine side-effects can be compared in future clinical trials.
Poland
Gregory A
GA
Mayo Vaccine Research Group, and Department of Medicine, Program in Translational Immunovirology and Biodefense, 611 C Guggenheim Building, 200 First Street, SW, Mayo Clinic and Foundation, Rochester, Minnesota, MN, USA. poland.gregory@mayo.edu
Grabenstein
John D
JD
Neff
John M
JM
D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology; D002417:Cattle; D005260:Female; D006282:Health Personnel; D006801:Humans; D008297:Male; D032541:Mass Vaccination / Q000009:adverse effects / Q000379:methods; D008889:Military Personnel; D009205:Myocarditis / Q000209:etiology; D009313:National Health Programs; D010493:Pericarditis / Q000209:etiology; D011247:Pregnancy; D012449:Safety; D012900:Smallpox Vaccine / Q000009:adverse effects / Q000302:isolation & purification; D014481:United States
D012900:Smallpox Vaccine