The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population.
BACKGROUND
Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population.


OBJECTIVE
To provide a review of PCT cases diagnosed in Argentina over 24 years and evaluate the role of different precipitating factors in its pathogenesis. Methods Plasma and urinary porphyrin levels and erythrocyte uroporphyrinogen decarboxylase (URO-D) activity were determined. Potential precipitating factors were identified in each patient. Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out.


RESULTS
Several factors (mainly alcohol abuse in men and estrogen ingestion in women), alone or combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found.


CONCLUSIONS
PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease.
Méndez
Manuel
M
National Research Institute on Porphyrins and Porphyrias (CIPYP), School of Sciences (FCEyN), University of Buenos Aires (UBA), and the Argentine National Research Council (CONICET), Buenos Aires, Argentina.
Rossetti
María V
MV
Del C Batlle
Alcira M
AM
Parera
Victoria E
VE
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D001118:Argentina / Q000453:epidemiology; D002648:Child; D005260:Female; D000071020:Hemochromatosis Protein; D006526:Hepatitis C / Q000503:physiopathology; D018937:Hepatitis C Antibodies / Q000097:blood; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D009154:Mutation; D017119:Porphyria Cutanea Tarda / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D015985:Precipitating Factors; D012189:Retrospective Studies; D012307:Risk Factors; D014575:Uroporphyrinogen Decarboxylase / Q000378:metabolism
C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D018937:Hepatitis C Antibodies; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D014575:Uroporphyrinogen Decarboxylase