[Intracytoplasmic sperm injection for Klinefelter patients and the risk of chromosome anomaly in the patients' offspring].
Patients with Klinefelter's syndrome are generally characterized by a 47, XXY karyotype, seminiferous tubule dysgenesis, azoospermia and infertility. However, focal spermatogenesis and severe oligozoospermia have been found in a few cases of 47, XXY, too. With the recent development in assisted reproductive technologies, the recovered spermatozoa by testicular biopsy from Klinefelter patients have been used for intracytoplasmic sperm injection (ICSI) and over 30 healthy neonates have been born. The conception of one 47, XXY fetus was found and then underwent abortion. This review focuses on the ICSI treatment of infertility in Klinefelter patients and the risk of chromosome anomaly in the offspring of these patients.
Zhou
Qin
Q
Laboratory of Reproduction and Genetics, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
Cui
Ying-Xia
YX
D025063:Chromosome Disorders / Q000209:etiology; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000628:therapy*; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000150:complications / Q000235:genetics*; D008297:Male; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic