title: Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes.
abstract: Pancreatic beta-cell dysfunction and insulin resistance are observed in type 2 diabetes. Under diabetic conditions, oxidative stress and ER stress are induced in various tissues, leading to activation of the JNK pathway. This JNK activation suppresses insulin biosynthesis and interferes with insulin action. Indeed, suppression of the JNK pathway in diabetic mice improves insulin resistance and ameliorates glucose tolerance. Thus, the JNK pathway plays a central role in pathogenesis of type 2 diabetes and may be a potential target for diabetes therapy.
authors.affiliation: Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. kaneto@medone.med.osaka-u.ac.jp
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.forename: Taka-Aki
authors.initials: TA
authors.lastname: Matsuoka
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nakatani
authors.forename: Dan
authors.initials: D
authors.lastname: Kawamori
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miyatsuka
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Yamasaki
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D007515:Islets of Langerhans / Q000473:pathology; D048031:JNK Mitogen-Activated Protein Kinases / Q000502:physiology*; D051379:Mice; D018384:Oxidative Stress; D015398:Signal Transduction
chemical_list: D048031:JNK Mitogen-Activated Protein Kinases