title: The taste of sickness: lipopolysaccharide-induced finickiness in rats.
abstract: Decrease in food intake is one of the most documented non-specific symptoms of inflammatory processes. However, attention has been mainly focused on quantitative analysis. The present paper reports studies undertaken to test the possible contribution of changes in taste processes in inflammatory-induced alteration of feeding behavior. In a first experiment, the effects of lipopolysaccharide-induced sickness were assessed on preference for saccharin and aversion for quinine in rats using the two-bottle test paradigm. In a second experiment, effect of lipopolysaccharide (LPS) on the behavioral reactivity to palatable, unpalatable and mixed solutions was analyzed using the taste-reactivity paradigm. Our results show that LPS decreased total fluid intake but did not change taste responses to unpalatable or palatable substances. However, LPS increased aversive reactions and decreased hedonic responses to mixed taste. These LPS-induced changes are interpreted as an increase in finickiness and are discussed in regard to their potential role in the adaptation of individuals to sickness.
authors.affiliation: EA 3248, Psychobiologie des Emotions, Faculté des Sciences, DESCO, Parc de Grandmont, F-37200 Tours, France. arnaud.aubert@univ-tours.fr
authors.forename: Arnaud
authors.initials: A
authors.lastname: Aubert
authors.forename: Robert
authors.initials: R
authors.lastname: Dantzer
mesh_terms: D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects*; D004926:Escherichia coli; D007274:Injections, Intraperitoneal; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D011803:Quinine; D051381:Rats; D017208:Rats, Wistar; D012439:Saccharin; D013649:Taste / Q000187:drug effects*
chemical_list: D008070:Lipopolysaccharides; D011803:Quinine; D012439:Saccharin