title: Maxillary sinus augmentation with platelet-rich plasma and fibrinogen cryoprecipitate: a tomographic pilot study.
abstract: The purpose of this study was to evaluate the clinical efficacy of platelet-rich plasma, autologous bone, and autologous fibrinogen as cryoprecipitate in maxillary sinus augmentation procedures. Six patients (age range, 29-58) undergoing sinus augmentation procedures were included in the study. Platelet-rich plasma and autologous fibrinogen in the form of cryoprecipitate were prepared from 300 ml of blood. Sinus augmentation was performed with intraoral bone grafts, platelet-rich plasma, and cryoprecipitate. The amount of regeneration was then evaluated quantitatively and qualitatively with Spiral TC (Dentascan) pre- and postoperatively 6 months after the intervention. Orthopantomography was performed preoperatively 3 and 6 months after the surgery. A mean platelet concentration of 320.5% was obtained from the baseline platelet blood count. The tomographic analysis indicated an average bone augmentation of 6.27 mm (range, 3.5-10 mm). Radiologically, a satisfactory morphological recovery of the maxillary jaw was obtained. No graft resorption was noticed. Orthopantomography indicated mineralization as early as 3 months postoperatively in the entire study population. This technique appeared to be safe and effective. Our preliminary results encourage the clinical use of platelet-rich plasma associated with cryoprecipitate.
authors.affiliation: Department of Neurosciences, Section of Oral Surgery, University of Pisa, Via Roma 67, 56100 Pisa, Italy. f.graziani@eastman.ucl.ac.uk
authors.forename: Filippo
authors.initials: F
authors.lastname: Graziani
authors.forename: Francesco
authors.initials: F
authors.lastname: Ducci
authors.forename: Matteo
authors.initials: M
authors.lastname: Tonelli
authors.forename: Abdel Salam
authors.initials: AS
authors.lastname: El Askary
authors.forename: Maha
authors.initials: M
authors.lastname: Monier
authors.forename: Mario
authors.initials: M
authors.lastname: Gabriele
mesh_terms: D000328:Adult; D000540:Alveolar Ridge Augmentation / Q000379:methods; D001792:Blood Platelets / Q000378:metabolism*; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000000981:diagnostic imaging* / Q000379:methods; D005169:Factor VIII / Q000627:therapeutic use*; D005340:Fibrinogen / Q000627:therapeutic use*; D005782:Gels; D006801:Humans; D008443:Maxillary Sinus / Q000000981:diagnostic imaging; D008875:Middle Aged; D010865:Pilot Projects; D010949:Plasma; D011862:Radiography, Panoramic; D036542:Tomography, Spiral Computed
chemical_list: D005782:Gels; C026912:cryoprecipitate coagulum; D005169:Factor VIII; D005340:Fibrinogen