title: Synchronous independent bifocal orthotopic thymomas. A case report.
abstract: A case of synchronous multiple thymomas is reported. The patient was an 81-year-old woman with 2 separate thymomas in the anterior mediastinum. A histological study revealed that both thymomas consisted of dense lymphocyte infiltration in the stroma and a small number of polygonal epithelial tumor cells with clear nuclei and distinct nucleoli. Immunohistochemical staining using the antibodies to 2 antigens, bcl-2, and MIB-1 showed identical staining patterns. In spite of these findings, we considered their origin to be synchronous multicentric development rather than intra-thymic metastasis, based on the non-invasive nature of these tumors.
authors.affiliation: Department of Surgery II, Kochi Medical School, Kohasu Nankoku, Kochi 783-8505, Japan. nonamiy@med.kochi-ms.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Nonami
authors.forename: T
authors.initials: T
authors.lastname: Moriki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D011859:Radiography; D013945:Thymoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D013953:Thymus Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery