Family clustering of blood cancers as a risk factor for lymphoid neoplasms.
Family aggregation of cancer was significantly more common among 588 incident cases with lymphoid neoplasms than among 631 controls (OR: 1.4; 95%CI= 1.1-1.8, p value=0.004). This association was of particular relevance among cases of multiple myeloma and chronic lymphocytic leukemia, with a 2-fold increased risk, the latter also showing an almost 4-fold increased risk of family aggregation of hematologic cancers.
Domingo-Domènech
Eva
E
Benavente
Yolanda
Y
Alvaro
Tomás
T
Hernández
Magdalena
M
de Sevilla
Alberto Fernández
AF
de Sanjosé
Silvia
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D016000:Cluster Analysis; D005192:Family Health; D005260:Female; D019337:Hematologic Neoplasms; D006801:Humans; D007945:Leukemia, Lymphoid / Q000209:etiology*; D008223:Lymphoma / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors