title: In vitro spasmolytic effect of aqueous extract of Calotropis procera on Guinea-pig trachea smooth muscle chain.
abstract: The aqueous extract of Calotropis procera was evaluated for its spasmolytic effect using in vitro trachea smooth muscle chain of Guinea-pig. The extract (50, 100 and 200 microg/ml) showed a dose-dependent relaxant activity probably exhibited through the direct relaxant action on the smooth muscle.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria. eoiwalewa@yahoo.com
authors.forename: Ezekiel O
authors.initials: EO
authors.lastname: Iwalewa
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Elujoba
authors.forename: Olanrewaju A
authors.initials: OA
authors.lastname: Bankole
mesh_terms: D000818:Animals; D031107:Calotropis; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014132:Trachea / Q000187:drug effects*
chemical_list: D010276:Parasympatholytics; D010936:Plant Extracts