Characteristic beta-globin gene cluster haplotypes of Evenkis and Oroqens in north China.
Haplotype frequencies of the beta-globin gene cluster were estimated for 114 Evenkis and 81 Oroqens from northeast China, and their characteristics were compared with those in Japanese, Koreans, and three Colombian Amerindian groups of South America (Wayuu, Kamsa, and Inga tribes). A major 5' subhaplotype (5' to the delta-globin gene) was + - - - - in Evenkis, whereas + - - - -, - + + - +, and - + - + + were the major subhaplotypes in Oroqens. One possible candidate for an ancestral 5' subhaplotype, - - - - -, was found in one Evenki (0.5%) and three Oroqen chromosomes (2.0%). They were observed as heterozygous forms for + ---- and -----. Major haplotypes were +-----+, + -----+-, and + - - - - + + in Evenkis, whereas they were +-----+,-++-+-+, +----+-, and -+-++-+ in Oroqens. The lowest Nei's genetic distance values of Evenkis or Oroqens based on the 5' subhaplotype frequency distributions were observed in relation to the Wayuu or Koreans, respectively, but those of Evenkis and Oroqens based on the haplotype frequency distributions were found in relation to Koreans.
Shimizu
Koji
K
Laboratory of Biology, Naruto University of Education, Tokushima 772-8502, Japan.
Marubayashi
Azusa
A
Tokimasa
Kozue
K
Harihara
Shinji
S
Omoto
Keiichi
K
Imanishi
Tadashi
T
Hao
Luping
L
Jin
Feng
F
D044466:Asian People / Q000235:genetics*; D001609:Beta-Globulins / Q000235:genetics*; D002681:China; D016000:Cluster Analysis; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D005810:Multigene Family; D012150:Polymorphism, Restriction Fragment Length
D001609:Beta-Globulins