title: Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation.
abstract: The effects of the phenolic compounds catechin (Cat), quercetin (Qer), and resveratrol (Res) present in red wine on early atherosclerosis were studied in hamsters. Hamsters (n = 32) were divided into 4 groups of 8 and fed an atherogenic diet for 12 weeks. They received by force-feeding 7.14 mL/(kg of body wt.day) Cat, Qer, or Res in water [2.856 mg/(kg of body wt.day) for Cat and 0.1428 mg/(kg of body wt.dday) for Qer and Res], mimicking a moderate consumption of alcohol-free red wine (equivalent to that supplied by the consumption of about two glasses of red wine per meal for a 70 kg human), or water as control. Plasma cholesterol concentration was lower in groups that consumed phenolics than in controls. The increase in plasma apolipoprotein (Apo) A1 concentration was mainly due to Cat (26%) and Qer (22%) and to a lesser extent, but nonsignificantly, Res (19%). Apo-B was not affected. Plasma antioxidant capacity was not improved, and there was no sparing effect on plasma vitamins A and E. Plasma iron and copper concentrations were not modified nor were liver super oxide dismutase and catalase activities. A sparing effect of Qer on liver glutathione peroxidase activity appeared, whereas Cat and Res exhibited a smaller effect. Aortic fatty streak area was significantly reduced in the groups receiving Cat (84%) or Qer (80%) or Res (76%) in comparison with the controls. These findings demonstrate that catechin, quercetin, and resveratrol at nutritional doses prevent the development of atherosclerosis through several indirect mechanisms.
authors.affiliation: Equipe d'Accueil 3762, Nutrition & Aliment, Université Montpellier 2, 34095 Montpellier, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Auger
authors.forename: Pierre-Louis
authors.initials: PL
authors.lastname: Teissedre
authors.forename: Peggy
authors.initials: P
authors.lastname: Gérain
authors.forename: Nadine
authors.initials: N
authors.lastname: Lequeux
authors.forename: Aurélie
authors.initials: A
authors.lastname: Bornet
authors.forename: Samuel
authors.initials: S
authors.lastname: Serisier
authors.forename: Pierre
authors.initials: P
authors.lastname: Besançon
authors.forename: Bertrand
authors.initials: B
authors.lastname: Caporiccio
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.forename: Jean-Max
authors.initials: JM
authors.lastname: Rouanet
mesh_terms: D000818:Animals; D001018:Aortic Diseases / Q000209:etiology / Q000517:prevention & control; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D002392:Catechin / Q000008:administration & dosage*; D006224:Cricetinae; D004195:Disease Models, Animal; D006937:Hypercholesterolemia / Q000150:complications*; D008297:Male; D008647:Mesocricetus; D011794:Quercetin / Q000008:administration & dosage*; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage*; D014920:Wine / Q000032:analysis*
chemical_list: D013267:Stilbenes; D002392:Catechin; D011794:Quercetin; D000077185:Resveratrol