[Effect of hypertension on cell proliferation and apoptosis in benign prostatic hyperplasia].
OBJECTIVE
To evaluate the effect of hypertension on cell proliferation and apoptosis in benign prostatic hyperplasia (BPH).


METHODS
The techniques of immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP biotin nick end labeling(TUNEL) were used to detect the proliferative index (PI) and apoptotic index (AI) in both epithelium and stroma of simple BPH (40 cases) and BPH with hypertension (40 cases), respectively.


RESULTS
In both the groups of simple BPH and BPH with hypertension, the value of PI was significantly higher than that of AI in epithelium and stroma (P < 0.05), and PI was closely related to the prostate volume (P < 0.05). As compared with the simple BPH group, PI was significantly increased in epithelium and stroma in the group of BPH with hypertension( P < 0.05), in which the disease history of hypertension was positively associated with PI in epithelium and stroma (p < 0.05).


CONCLUSIONS
Hypertension, particularly persistent hypertension state, may enhance cell proliferation in both epithelium and stroma of BPH, and consequently lead to the enlargement of the prostate.
Li
Pei-Jun
PJ
Department of Urology, Peking University First Hospital/Institute of Urology, Peking University, Beijing 100034, China.
Zhang
Xiang-Hua
XH
Guo
Li-Jun
LJ
Na
Yan-Qun
YQ
D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000502:physiology*; D049109:Cell Proliferation; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*