[Effect of extracellular Ca2+ on neuronal function].
Metabotropic glutamate receptors (mGluR) are well known to have a significance for the plastic change of synaptic neurotransmission. We observed that mGluR can be activated not only by glutamate but also by extracellular Ca(2+) of physiological concentration. Our observation suggests that extracellular Ca(2+) plays a critical role for the neuronal function, not only by serving as a source to elevate intracellular Ca(2+) concentration by entering through various channels, but also by activating metabotropic glutamate receptors as a ligand.
Miyashita
T
T
Tokyo Metropolitan Institute for Neuroscience, Department of Molecular Neurophysiology.
Abe
H
H
Kubo
Y
Y